Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 150417986
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150417986 ADP-ribosylation factor guanine
nucleotide-exchange factor 2 [Homo sapiens]
(1785 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange... 3559 0.0
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr... 2654 0.0
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti... 258 5e-68
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 194 5e-49
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 194 5e-49
gi|4758968 cytohesin 3 [Homo sapiens] 187 1e-46
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 179 3e-44
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 179 3e-44
gi|7019505 cytohesin 4 [Homo sapiens] 172 2e-42
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens] 152 2e-36
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens] 152 2e-36
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens] 149 2e-35
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens] 147 7e-35
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens] 147 7e-35
gi|154350241 brefeldin A-inhibited guanine nucleotide-exchange p... 92 6e-18
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ... 89 5e-17
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6... 89 5e-17
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens] 89 5e-17
gi|48928044 F-box only protein 8 [Homo sapiens] 87 1e-16
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens] 85 7e-16
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens] 82 4e-15
gi|114326552 MON2 homolog [Homo sapiens] 79 4e-14
gi|224593754 AXIN1 up-regulated 1 [Homo sapiens] 35 0.65
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 34 1.1
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 34 1.5
gi|6912702 transcription factor EC isoform a [Homo sapiens] 34 1.5
gi|214831834 transmembrane protein 169 [Homo sapiens] 33 2.5
gi|19923913 transmembrane protein 169 [Homo sapiens] 33 2.5
gi|214831799 transmembrane protein 169 [Homo sapiens] 33 2.5
gi|214831780 transmembrane protein 169 [Homo sapiens] 33 2.5
>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
factor 2 [Homo sapiens]
Length = 1785
Score = 3559 bits (9228), Expect = 0.0
Identities = 1785/1785 (100%), Positives = 1785/1785 (100%)
Query: 1 MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA 60
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA
Sbjct: 1 MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA 60
Query: 61 NFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVE 120
NFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVE
Sbjct: 61 NFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVE 120
Query: 121 TICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT 180
TICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
Sbjct: 121 TICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT 180
Query: 181 TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQS 240
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQS
Sbjct: 181 TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQS 240
Query: 241 KPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSA 300
KPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSA
Sbjct: 241 KPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSA 300
Query: 301 IKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH 360
IKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH
Sbjct: 301 IKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGH 360
Query: 361 QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGP 420
QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGP
Sbjct: 361 QVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGP 420
Query: 421 VFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKE 480
VFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKE
Sbjct: 421 VFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKE 480
Query: 481 IFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI 540
IFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI
Sbjct: 481 IFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKI 540
Query: 541 AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQE 600
AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQE
Sbjct: 541 AQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQE 600
Query: 601 IGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKR 660
IGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKR
Sbjct: 601 IGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKR 660
Query: 661 GIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK 720
GIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK
Sbjct: 661 GIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEK 720
Query: 721 EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLT 780
EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLT
Sbjct: 721 EFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLT 780
Query: 781 TDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATK 840
TDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATK
Sbjct: 781 TDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATK 840
Query: 841 STKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP 900
STKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP
Sbjct: 841 STKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP 900
Query: 901 LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSI 960
LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSI
Sbjct: 901 LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSI 960
Query: 961 TEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGRE 1020
TEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGRE
Sbjct: 961 TEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGRE 1020
Query: 1021 REGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST 1080
REGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST
Sbjct: 1021 REGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGST 1080
Query: 1081 RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGD 1140
RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGD
Sbjct: 1081 RLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGD 1140
Query: 1141 HFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIR 1200
HFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIR
Sbjct: 1141 HFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIR 1200
Query: 1201 DMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF 1260
DMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF
Sbjct: 1201 DMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHF 1260
Query: 1261 PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAP 1320
PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAP
Sbjct: 1261 PAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAP 1320
Query: 1321 GDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFR 1380
GDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFR
Sbjct: 1321 GDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFR 1380
Query: 1381 IFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN 1440
IFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN
Sbjct: 1381 IFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDN 1440
Query: 1441 EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE 1500
EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE
Sbjct: 1441 EQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE 1500
Query: 1501 KHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIKCVVQLELI 1560
KHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIKCVVQLELI
Sbjct: 1501 KHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIKCVVQLELI 1560
Query: 1561 QTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQE 1620
QTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQE
Sbjct: 1561 QTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQE 1620
Query: 1621 SHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWE 1680
SHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWE
Sbjct: 1621 SHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWE 1680
Query: 1681 EIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLC 1740
EIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLC
Sbjct: 1681 EIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLC 1740
Query: 1741 EIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW 1785
EIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW
Sbjct: 1741 EIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW 1785
>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange protein
1 [Homo sapiens]
Length = 1849
Score = 2654 bits (6878), Expect = 0.0
Identities = 1381/1845 (74%), Positives = 1537/1845 (83%), Gaps = 85/1845 (4%)
Query: 5 QTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQ-------RLGTAAP 57
+TK+MF++RALEKILADKEVK+ HSQLR+AC+VAL+EIKAE EKQ + G++
Sbjct: 6 KTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTL 65
Query: 58 P----KANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKR 113
P K NFIEADKYFLPFELACQSK PR+VSTSLDCLQKLIAYGH+TGNAPDS PGK+
Sbjct: 66 PPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKK 125
Query: 114 LIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLAS 173
LIDRI+ETIC CFQGPQTDEGVQLQIIKALLTAVTS HIEIHEGT+LQ VRTCYNIYLAS
Sbjct: 126 LIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYNIYLAS 185
Query: 174 KNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKP----QSPVIQAAAVSPK 229
KNLINQTTAKATLTQMLNVIF RMENQ LQEA+++EK + QSPV SP+
Sbjct: 186 KNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHEPESPQ 245
Query: 230 FVRLK-----------------HSQAQSKP----TTPEK-TDLTNGEHARSDSGKVSTEN 267
L H+ K T PE +D+++ E+ ++++ + +
Sbjct: 246 LRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQATAAE 305
Query: 268 GDAPRE--RGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQEC 325
+ E ++ Q++V++I+E++V + + E G T G +
Sbjct: 306 TLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGE--GTTINASADGNIG---- 359
Query: 326 AIPPGVD-ENSQTNGIA-------------DDRQSLSSADNLES-DAQGHQVAARFSHVL 370
I G D EN Q NGI DDR S+SS D ES ++ G A+FSH+L
Sbjct: 360 TIEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHIL 419
Query: 371 QKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFIN 430
QKDAFLVFRSLCKLSMKPL +GPPDPKSHELRSK++SLQLLLS+LQNAGP+FRT+EMFIN
Sbjct: 420 QKDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFIN 479
Query: 431 AIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETST 490
AIKQYLCVALSKNGVSSVP+VFELSL+IFLTLLSNFK HLKMQIEVFFKEIFL ILETST
Sbjct: 480 AIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETST 539
Query: 491 SSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELG 550
SSF+H+WMVIQTLTRICADAQ VVDIYVNYDCDLNAANIFERLVNDLSKIAQGR ELG
Sbjct: 540 SSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELG 599
Query: 551 MTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMA 610
M+ +QELSLRKKGLECLVSILKCMVEWSKD YVNPN QT+LGQE+ ++QE+ + K +
Sbjct: 600 MSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETI 659
Query: 611 RRC-SVTSMESTVSSG-----TQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQF 664
R S+ S+EST SSG TQ + D+PEQFEV+KQQKEIIE GI+LFNKKPKRGIQ+
Sbjct: 660 NRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQY 719
Query: 665 LQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVS 724
LQEQGMLGT+ EDIAQFLHQEERLDSTQVG+FLGD+ +FNKEVMYAYVDQ DF K+FVS
Sbjct: 720 LQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVS 779
Query: 725 ALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLH 784
ALR FLEGFRLPGEAQKIDRLMEKFAARY+ECNQGQTLFASADTAYVLAYSIIMLTTDLH
Sbjct: 780 ALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLH 839
Query: 785 SPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQ 844
SPQVKNKMTKEQYIKMNRGINDSKDLPEEYLS+IY EI GKKI+MKETKELTI TKS+KQ
Sbjct: 840 SPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQ 899
Query: 845 NVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAA 904
NVASEKQRRLLYNLEMEQMAKTAKALMEAVSH +APFTSATHL+HVRPMFKL WTP LAA
Sbjct: 900 NVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAA 959
Query: 905 YSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMK 964
+S+GLQ+CDDTEVASLCLEGIRCAIRIACIF +QLERDAYVQALARF+LLT SS ITEMK
Sbjct: 960 FSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMK 1019
Query: 965 QKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGS 1024
QKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVK RY+SG+ R REGS
Sbjct: 1020 QKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGS 1079
Query: 1025 LKG-HTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLD 1083
L G A +EF+GLGL V G VD +Q+AS QES+GETSSQSVVVAVDRIFTGSTRLD
Sbjct: 1080 LTGTKDQAPDEFVGLGL---VGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLD 1136
Query: 1084 GNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFN 1143
GNAIVDFVRWLCAVSMDEL S HPRMFSLQKIVEISYYNM RIRLQWSRIW VIGDHFN
Sbjct: 1137 GNAIVDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFN 1196
Query: 1144 KVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMA 1203
KVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMK+NRSPTIRDM
Sbjct: 1197 KVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMV 1256
Query: 1204 IRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAA 1263
+RCIAQMVNSQAANIRSGWKNIF+VFH AASD D +IVELAFQTT HIVT +F+ HFPA
Sbjct: 1257 VRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPAT 1316
Query: 1264 IDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDR 1323
IDSFQDAVKCLSEFACNAAFPDTSMEAIRLIR C KYVS+RP+ +EYTSDDMNVAP DR
Sbjct: 1317 IDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDR 1376
Query: 1324 VWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFD 1383
VWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMK+YGHT+EKHWWQDLFRIVFRIFD
Sbjct: 1377 VWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFD 1436
Query: 1384 NMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDNEQL 1443
NMKLPEQ +EK+EWMTTTCNHALYAICDVFTQ+ E L++VLL D+FAQL WCV+QDNEQL
Sbjct: 1437 NMKLPEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQL 1496
Query: 1444 ARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGME------ED 1497
ARSGTNCLEN+VI NGEKF+ E+WD+TCNC LDIFKTTIPH LLTWRP E
Sbjct: 1497 ARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSP 1556
Query: 1498 SSEKHLD------VDL-DRQSLSSIDKNPSER--GQSQLSNPTDDSWKGRPYANQKLFAS 1548
SEK LD VD+ D S+D P S ++ + QKLFA+
Sbjct: 1557 VSEKPLDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAA 1616
Query: 1549 LLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSS 1608
LLIKCVVQLELIQTIDNIVF+PATSKKEDAE++ AAQ+D +D D+ ++T+DQGMY++++S
Sbjct: 1617 LLIKCVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTS 1676
Query: 1609 QHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFR 1668
Q LFKLLDCL ESH F+KAFNSN EQRT LW+AGFKGKSKPNLLKQETSSLAC LRILFR
Sbjct: 1677 QQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFR 1736
Query: 1669 MYVDENRRDSWEEIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKF 1728
MY+DE+R +WEE+QQRLL VCSEAL+YF+T+ SESHREAWT+LLLL LTK LKI+D +F
Sbjct: 1737 MYMDESRVSAWEEVQQRLLNVCSEALSYFLTLTSESHREAWTNLLLLFLTKVLKISDNRF 1796
Query: 1729 KAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEE 1773
KAHAS YYP LCEIMQFDLIPELRAVLR+FFLRIGVV++I P E
Sbjct: 1797 KAHASFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQPPE 1841
>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
exchange factor 1 [Homo sapiens]
Length = 1859
Score = 258 bits (658), Expect = 5e-68
Identities = 301/1265 (23%), Positives = 546/1265 (43%), Gaps = 153/1265 (12%)
Query: 63 IEADKYFLPFELACQSKSPR--VVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVE 120
IE + + PF +S+ + +L + K ++Y I + + + D +
Sbjct: 59 IEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMADAVTH 118
Query: 121 TICSCFQG--PQTDEGVQLQIIKALLTAVTSP-HIEIHEGTILQTVRTCYNIYLASK-NL 176
+ F G P +DE V ++I++ L T + +P + ++ + +++C+ I + +
Sbjct: 119 ---ARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSE 175
Query: 177 INQTTAKATLTQMLNVIFTRM-------ENQVLQEARELEKPIQSKPQSPVIQAAAVSPK 229
+ + +A+ TL M+ ++FTR+ +N V ++L+ S + SP+
Sbjct: 176 LLRKSAEHTLVDMVQLLFTRLPQFKEEPKNYVGTNMKKLKMRAGGMSDSSKWKKQKRSPR 235
Query: 230 FVR-LKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSL------SGTD 282
R + S+ TP T L++ V T A E S++ SG +
Sbjct: 236 PPRHMTKVTPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEAASAVVSPSTDSGLE 295
Query: 283 DGAQEVVKDILEDV-------VTSAIKEAAEKHGLTE-PERVLG-ELECQECAIPPGVDE 333
+Q K+ L D+ ++A + + + G+ E P+ G +E + A + E
Sbjct: 296 FSSQTTSKEDLTDLEQPGSPGYSTATEPGSSELGVPEQPDLQEGTHVEKSQSASVESIPE 355
Query: 334 N-SQTNGIADDRQSLSSADNLESDAQGHQVAARFSHVLQKDAFLV-----------FRSL 381
+ AD S S D + +G RF+ QK+ + FR L
Sbjct: 356 VLEECTSPADHSDSASVHDMDYVNPRG----VRFTQSSQKEGTALVPYGLPCIRELFRFL 411
Query: 382 CKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALS 441
L+ P D + E+ + L LL L++A PV + + + IK +C L
Sbjct: 412 ISLT------NPHDRHNSEVMIHM-GLHLLTVALESA-PVAQCQTL-LGLIKDEMCRHLF 462
Query: 442 KNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNI-LETSTSSFEHRWMVI 500
+ +++ SL + L + + HLK Q+E++ K++ I +E +E + M +
Sbjct: 463 QLLSIERLNLYAASLRVCFLLFESMREHLKFQMEMYIKKLMEIITVENPKMPYEMKEMAL 522
Query: 501 QTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELS-- 558
+ + ++ V ++Y+NYDCD +N+FE L LSK A SG +L T L L
Sbjct: 523 EAIVQLWRIPSFVTELYINYDCDYYCSNLFEELTKLLSKNAFPVSG-QLYTTHLLSLDAL 581
Query: 559 ---LRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERL--TDQEIGDGKGLDMAR-- 611
+ C +L + + K P+ + G T++ DGK + MA
Sbjct: 582 LTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVDGTREASNTERTASDGKAVGMASDI 641
Query: 612 ----------------RCSVTSMESTVSSGTQ----------TTVQDDPEQFEVIKQQKE 645
+ + +E V SG + + DP + IK +K+
Sbjct: 642 PGLHLPGGGRLPPEHGKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKK 701
Query: 646 IIEHGIELFNKKPKRGIQFLQEQGMLGTSVE--DIAQFLHQEERLDSTQVGDFLGDSARF 703
++ G E FN+KPK+GIQFLQE+G+L ++ ++AQ+L + RLD +G+F+ D R
Sbjct: 702 LLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSD--RK 759
Query: 704 NKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLF 763
N +++ ++V F ALR +LE FRLPGEA I RL+E F R++ CN F
Sbjct: 760 NIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSP--F 817
Query: 764 ASADTAYVLAYSIIMLTTDLHSPQVKNK---MTKEQYIKMNRGINDSKDLPEEYLSSIYE 820
A++D + LAY++IML TD H+ V+ + MT E++ K +G+N KD ++ L +Y
Sbjct: 818 ANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYH 877
Query: 821 EIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAP 880
I+ ++I M E + T ++N ++N+ + + A T + + V
Sbjct: 878 AIKNEEIVMPEEQ-----TGLVREN--------YVWNVLLHRGA-TPEGIFLRVP----- 918
Query: 881 FTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLE 940
T++ LD +F + W P +AA S + + + G R I+ +G+
Sbjct: 919 -TASYDLD----LFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDV 973
Query: 941 RDAYVQALARFSLLTASS-----SITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKC 995
D + +L +F+ L++ S S+ K KT+ +AH G+ L W I++
Sbjct: 974 FDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEA 1033
Query: 996 ISQLELAQLIGTGV--KTRYLSGSG-----REREGSLKGHTLAGEEFMGLGLGNLVSGGV 1048
+ QL AQL+ + ++ +G RE S +G + L L V
Sbjct: 1034 MLQLFRAQLLPKAMIEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSV 1093
Query: 1049 DKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHP 1108
+ QE+ +++ T S L ++ + ++ L +V+ DE
Sbjct: 1094 -RGPSTENQEAKRVALECIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEED 1152
Query: 1109 RMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIF---AVDSLRQLS 1165
F L+ ++ I N +R+ +W + DH + C +D AV L +L+
Sbjct: 1153 AAFCLEMLLRIVLENRDRV----GCVWQTVRDHLYHL-CVQAQDFCFLVERAVVGLLRLA 1207
Query: 1166 MKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAANIRSG--WK 1223
++ L + E++ Q +MK + + + +++ + AANI SG W
Sbjct: 1208 IRLLRREEIS---AQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWA 1264
Query: 1224 NIFAV 1228
+F +
Sbjct: 1265 TLFTL 1269
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 194 bits (494), Expect = 5e-49
Identities = 98/190 (51%), Positives = 133/190 (70%), Gaps = 2/190 (1%)
Query: 642 QQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701
Q+ + + G + FN PK+GIQFL E +L + EDIAQFL++ E L+ T +GD+LG+
Sbjct: 61 QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120
Query: 702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT 761
FN +V++A+V+ +F + V ALR FL FRLPGEAQKIDR+ME FA RY +CN G
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNG-- 178
Query: 762 LFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEE 821
+F S DT YVL+++IIML T LH+P VK+K T E++I MNRGIND DLPEE L ++YE
Sbjct: 179 VFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYES 238
Query: 822 IEGKKIAMKE 831
I+ + + E
Sbjct: 239 IKNEPFKIPE 248
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 194 bits (494), Expect = 5e-49
Identities = 98/190 (51%), Positives = 133/190 (70%), Gaps = 2/190 (1%)
Query: 642 QQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701
Q+ + + G + FN PK+GIQFL E +L + EDIAQFL++ E L+ T +GD+LG+
Sbjct: 61 QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120
Query: 702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT 761
FN +V++A+V+ +F + V ALR FL FRLPGEAQKIDR+ME FA RY +CN G
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNG-- 178
Query: 762 LFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEE 821
+F S DT YVL+++IIML T LH+P VK+K T E++I MNRGIND DLPEE L ++YE
Sbjct: 179 VFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYES 238
Query: 822 IEGKKIAMKE 831
I+ + + E
Sbjct: 239 IKNEPFKIPE 248
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 187 bits (474), Expect = 1e-46
Identities = 96/190 (50%), Positives = 132/190 (69%), Gaps = 2/190 (1%)
Query: 642 QQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701
Q+ + I G + FN PK+GIQFL E +L +S ED+AQFL++ E L+ T +GD+LG+
Sbjct: 65 QRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERD 124
Query: 702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT 761
FN +V+ A+V+ +F + V ALR FL FRLPGEAQKIDR+ME FA+RY CN G
Sbjct: 125 EFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPG-- 182
Query: 762 LFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEE 821
+F S DT YVL+++IIML T LH+ V++K T E++I MNRGIN+ DLPEE L ++YE
Sbjct: 183 VFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYES 242
Query: 822 IEGKKIAMKE 831
I+ + + E
Sbjct: 243 IKNEPFKIPE 252
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 179 bits (453), Expect = 3e-44
Identities = 90/190 (47%), Positives = 127/190 (66%), Gaps = 2/190 (1%)
Query: 642 QQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701
Q+ + G + FN PK+GIQFL E +L + E+IA+FL++ E L+ T +GD+LG+
Sbjct: 60 QRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE 119
Query: 702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT 761
N V++A+VD +F + V ALR FL FRLPGEAQKIDR+ME FA RY CN G
Sbjct: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPG-- 177
Query: 762 LFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEE 821
+F S DT YVL++++IML T LH+P V++K E+++ MNRGIN+ DLPEE L ++Y+
Sbjct: 178 VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDS 237
Query: 822 IEGKKIAMKE 831
I + + E
Sbjct: 238 IRNEPFKIPE 247
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 179 bits (453), Expect = 3e-44
Identities = 90/190 (47%), Positives = 127/190 (66%), Gaps = 2/190 (1%)
Query: 642 QQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701
Q+ + G + FN PK+GIQFL E +L + E+IA+FL++ E L+ T +GD+LG+
Sbjct: 60 QRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE 119
Query: 702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT 761
N V++A+VD +F + V ALR FL FRLPGEAQKIDR+ME FA RY CN G
Sbjct: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPG-- 177
Query: 762 LFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEE 821
+F S DT YVL++++IML T LH+P V++K E+++ MNRGIN+ DLPEE L ++Y+
Sbjct: 178 VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDS 237
Query: 822 IEGKKIAMKE 831
I + + E
Sbjct: 238 IRNEPFKIPE 247
>gi|7019505 cytohesin 4 [Homo sapiens]
Length = 394
Score = 172 bits (437), Expect = 2e-42
Identities = 88/200 (44%), Positives = 132/200 (66%), Gaps = 3/200 (1%)
Query: 632 DDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDST 691
+ E+ + +++KE+ G + FN P +GIQ+ E +L V+DIA+FL++ E L+ T
Sbjct: 51 ESAEESRMAQKEKELCI-GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKT 109
Query: 692 QVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAA 751
+G +LG+ N +V+ A+VD +F V ALR FL FRLPGEAQKIDR+ME FA
Sbjct: 110 AIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAT 169
Query: 752 RYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLP 811
RY CN G +F S DT YVL++SIIML T LH+P V+++ E+++ MNRGIN+ DLP
Sbjct: 170 RYCLCNPG--VFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLP 227
Query: 812 EEYLSSIYEEIEGKKIAMKE 831
E+ L ++++ I+ + ++ E
Sbjct: 228 EDQLRNLFDSIKSEPFSIPE 247
>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
Length = 1114
Score = 152 bits (385), Expect = 2e-36
Identities = 79/186 (42%), Positives = 119/186 (63%), Gaps = 4/186 (2%)
Query: 650 GIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSAR-FNKEVM 708
G+ LFNKKP++G+Q+L E+G + + +A FL Q + L +G+FLG+ + FN++V+
Sbjct: 517 GLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVL 576
Query: 709 YAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT-LFASAD 767
VD++DF E ALR F R+ GEAQK++RL+E F+ RY CN G F + D
Sbjct: 577 DCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPD 636
Query: 768 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGK 825
T ++LA++II+L TD++SP VK KM E +IK RG++D +D+P E L IYE I +
Sbjct: 637 TIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKR 696
Query: 826 KIAMKE 831
++ E
Sbjct: 697 ELKTNE 702
>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
Length = 963
Score = 152 bits (385), Expect = 2e-36
Identities = 79/186 (42%), Positives = 119/186 (63%), Gaps = 4/186 (2%)
Query: 650 GIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSAR-FNKEVM 708
G+ LFNKKP++G+Q+L E+G + + +A FL Q + L +G+FLG+ + FN++V+
Sbjct: 531 GLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVL 590
Query: 709 YAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT-LFASAD 767
VD++DF E ALR F R+ GEAQK++RL+E F+ RY CN G F + D
Sbjct: 591 DCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPD 650
Query: 768 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGK 825
T ++LA++II+L TD++SP VK KM E +IK RG++D +D+P E L IYE I +
Sbjct: 651 TIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKR 710
Query: 826 KIAMKE 831
++ E
Sbjct: 711 ELKTNE 716
>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
Length = 759
Score = 149 bits (377), Expect = 2e-35
Identities = 90/248 (36%), Positives = 141/248 (56%), Gaps = 11/248 (4%)
Query: 643 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSAR 702
+K + G+ LFN P +GIQFL +G + + +A FL Q + L +G+FLG+S +
Sbjct: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407
Query: 703 -FNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECN-QGQ 760
FN++V+ VD++DF E ALR F R+ GEAQK++RL+E F+ RY CN +
Sbjct: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467
Query: 761 TLFASADTAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSSI 818
F + DT ++LA++II+L TD++SP +K KM E +I+ RG++D D+P E + I
Sbjct: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527
Query: 819 YEEIEGKKIAMKETKELTIATKSTK-----QNVASEKQRRLLYNLEMEQMAKTAKALMEA 873
YE I+ K++ E +T TK K + V S RRL+ + ++ K L +
Sbjct: 528 YERIQQKELKSNE-DHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNK-LQKQ 585
Query: 874 VSHAKAPF 881
+H + F
Sbjct: 586 AAHQREVF 593
>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
Length = 949
Score = 147 bits (372), Expect = 7e-35
Identities = 73/182 (40%), Positives = 119/182 (65%), Gaps = 4/182 (2%)
Query: 650 GIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSAR-FNKEVM 708
G+ LFNKKP++GIQ+L E+G L + +A F+ + + L +G+FLG+ + FN++V+
Sbjct: 555 GLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVL 614
Query: 709 YAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT-LFASAD 767
VD++DF + ALR F R+ GEAQK++RL+E F+ RY CN F + D
Sbjct: 615 DCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPD 674
Query: 768 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGK 825
T ++LA++II+L TD++SP VK KM + +IK RG+++ +D+P + L IY+ I+G+
Sbjct: 675 TIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGR 734
Query: 826 KI 827
++
Sbjct: 735 EL 736
>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
Length = 1488
Score = 147 bits (372), Expect = 7e-35
Identities = 73/182 (40%), Positives = 119/182 (65%), Gaps = 4/182 (2%)
Query: 650 GIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSAR-FNKEVM 708
G+ LFNKKP++GIQ+L E+G L + +A F+ + + L +G+FLG+ + FN++V+
Sbjct: 760 GLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVL 819
Query: 709 YAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT-LFASAD 767
VD++DF + ALR F R+ GEAQK++RL+E F+ RY CN F + D
Sbjct: 820 DCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPD 879
Query: 768 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGK 825
T ++LA++II+L TD++SP VK KM + +IK RG+++ +D+P + L IY+ I+G+
Sbjct: 880 TIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGR 939
Query: 826 KI 827
++
Sbjct: 940 EL 941
>gi|154350241 brefeldin A-inhibited guanine nucleotide-exchange
protein 3 [Homo sapiens]
Length = 2177
Score = 91.7 bits (226), Expect = 6e-18
Identities = 126/627 (20%), Positives = 244/627 (38%), Gaps = 119/627 (18%)
Query: 1133 RIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFL-EKGELANFRFQKDFLRPFEHIM 1191
R W ++ H + C+ V+ AV + + + L + E +F F + RPFE IM
Sbjct: 1205 RCWSLVAPHLVEAACHKERHVSQKAVSFIHDILTEVLTDWNEPPHFHFNEALFRPFERIM 1264
Query: 1192 KKNR-SPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVEL------- 1243
+ ++D + I ++V + I+SGW+ +F+ H GN E+
Sbjct: 1265 QLELCDEDVQDQVVTSIGELVEVCSTQIQSGWRPLFSALETV---HGGNKSEMKEYLVGD 1321
Query: 1244 ---------------AFQTTCHIVTTIFQHHFPAAIDSFQDAVKCLSEFACN-------- 1280
AF T +I +F + + I VK L E C
Sbjct: 1322 YSMGKGQAPVFDVFEAFLNTDNI--QVFANAATSYIMCLMKFVKGLGEVDCKEIGDCAPA 1379
Query: 1281 --AAFPDTSMEAIRLIRFCGKYVSE-----------------RPRVLQEYTSDD------ 1315
A D + A+ +R C + +++ PR LQE ++
Sbjct: 1380 PGAPSTDLCLPALDYLRRCSQLLAKIYKMPLKPIFLSGRLAGLPRRLQEQSASSEDGIES 1439
Query: 1316 -MNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDL 1374
++ D + W +L +L+ ++ C + L ++FE+++ T + +
Sbjct: 1440 VLSDFDDDTGLIEVWIILLEQLTAAVSNCPRQHQPPTLDLLFELLRDVTKTPGPGF--GI 1497
Query: 1375 FRIVFRIFDNMKLPEQLSEK--SEWMTTTCN--HALYAICDVFTQF----------YEAL 1420
+ +V + M + + S K S W + N HA+ C++ + YE++
Sbjct: 1498 YAVVHLLLPVMSVWLRRSHKDHSYWDMASANFKHAIGLSCELVVEHIQSFLHSDIRYESM 1557
Query: 1421 NEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKT 1480
+L D+F L CV + E ++R G +C+ ++++ G F+ E+W C + D F
Sbjct: 1558 INTMLKDLFELLVACVAKPTETISRVGCSCIRYVLVTAGPVFTEEMWRLACCALQDAFSA 1617
Query: 1481 TIPHV--LLTWRPVGMEEDSSE-----------------KHLDVDLDRQSLSSID----- 1516
T+ V LL G E S E ++ + Q + +D
Sbjct: 1618 TLKPVKDLLGCFHSGTESFSGEGCQVRVAAPSSSPSAEAEYWRIRAMAQQVFMLDTQCSP 1677
Query: 1517 KNPSERGQSQ-----LSNPTDDSWKGRPYANQKLFASLLIKCVVQLELIQTIDNIVFYPA 1571
K P+ +Q + P D+ G + F +++ + L+Q + +I+
Sbjct: 1678 KTPNNFDHAQSCQLIIELPPDEKPNGHTKKSVS-FREIVVSLLSHQVLLQNLYDILL--- 1733
Query: 1572 TSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSN 1631
+E + ++ T+ E + G +Y+S Q+L + D L +S+ ++ F+++
Sbjct: 1734 ---EEFVKGPSPGEEKTIQVP---EAKLAGFLRYISMQNLAVIFDLLLDSYRTAREFDTS 1787
Query: 1632 YEQRTVLWRAGFKGKSKPNLLKQETSS 1658
+ +L + G NL +Q S
Sbjct: 1788 PGLKCLLKKVSGIG-GAANLYRQSAMS 1813
Score = 60.1 bits (144), Expect = 2e-08
Identities = 50/201 (24%), Positives = 101/201 (50%), Gaps = 19/201 (9%)
Query: 15 LEKILA--DKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPF 72
+E+IL KE ++ ++ +C AL+ + ++ PP + +K LP
Sbjct: 1 MEEILRKLQKEASGSKYKAIKESCTWALETLGGLDTIVKI----PPH---VLREKCLLPL 53
Query: 73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTD 132
+LA +SK+ ++ +L +QKL++ DS K+L+++I+ + P +
Sbjct: 54 QLALESKNVKLAQHALAGMQKLLSEERFVSMETDSDE--KQLLNQILNAVKVT---PSLN 108
Query: 133 EGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLAS--KNLINQTTAKATLTQML 190
E +Q++++K LL +P +++ +L+ C Y++S + IN T +ATL+QML
Sbjct: 109 EDLQVEVMKVLLCITYTPTFDLNGSAVLKIAEVCIETYISSCHQRSIN-TAVRATLSQML 167
Query: 191 NVIFTRMENQVLQEARELEKP 211
+ + ++ + QE +E P
Sbjct: 168 SDLTLQLRQR--QENTIIENP 186
>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
isoform b [Homo sapiens]
Length = 513
Score = 88.6 bits (218), Expect = 5e-17
Identities = 51/169 (30%), Positives = 92/169 (54%), Gaps = 4/169 (2%)
Query: 678 IAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPG 737
+A+ L+Q +R + V LG + F+K V Y+ DF +LR F + F L G
Sbjct: 54 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113
Query: 738 EAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 797
E Q+ +R++ F+ RY CN AS D + L +I++L TDLH + KMT +++
Sbjct: 114 ETQERERVLIHFSNRYFYCN--PDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 171
Query: 798 IKMNRGINDSKDLPEEYLSSIYEEIEGKKI--AMKETKELTIATKSTKQ 844
I +G+N+ D ++ L ++Y I+ +K+ A+ + ++ ++ST++
Sbjct: 172 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEE 220
>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
isoform a [Homo sapiens]
Length = 1047
Score = 88.6 bits (218), Expect = 5e-17
Identities = 51/169 (30%), Positives = 92/169 (54%), Gaps = 4/169 (2%)
Query: 678 IAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPG 737
+A+ L+Q +R + V LG + F+K V Y+ DF +LR F + F L G
Sbjct: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647
Query: 738 EAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 797
E Q+ +R++ F+ RY CN AS D + L +I++L TDLH + KMT +++
Sbjct: 648 ETQERERVLIHFSNRYFYCN--PDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 705
Query: 798 IKMNRGINDSKDLPEEYLSSIYEEIEGKKI--AMKETKELTIATKSTKQ 844
I +G+N+ D ++ L ++Y I+ +K+ A+ + ++ ++ST++
Sbjct: 706 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEE 754
>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
Length = 1056
Score = 88.6 bits (218), Expect = 5e-17
Identities = 50/192 (26%), Positives = 97/192 (50%), Gaps = 2/192 (1%)
Query: 677 DIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLP 736
++A L++ E ++V +L + F++ V Y+ F + ALR+FL+ L
Sbjct: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
Query: 737 GEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQ 796
GE Q+ +R++ +F+ R+ CN G +F S D+ + L +I++L TDLH + M+ ++
Sbjct: 650 GETQERERILYQFSRRFHHCNPG--IFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQE 707
Query: 797 YIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLY 856
+I G+ D + P+E L ++Y I +K+ +E T + + ++ + K +
Sbjct: 708 FITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFL 767
Query: 857 NLEMEQMAKTAK 868
L + T K
Sbjct: 768 QLAQDPTVPTYK 779
>gi|48928044 F-box only protein 8 [Homo sapiens]
Length = 319
Score = 87.0 bits (214), Expect = 1e-16
Identities = 53/179 (29%), Positives = 97/179 (54%), Gaps = 9/179 (5%)
Query: 647 IEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKE 706
++ G FN P G+ + +G+L S ++IA+F+ L+ ++ +L + ++
Sbjct: 139 LDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDE----RRD 194
Query: 707 VMYAYVDQLDFCEKEFVSALRTFLEGFRLPGE-AQKIDRLMEKFAARYIECNQG--QTLF 763
V+ V +F + +ALR F P E + ++ L+ KF+ R+ CN + L
Sbjct: 195 VLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELG 254
Query: 764 ASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEI 822
S D YVL YS+I+L+ DL SP VKNKM+K ++I+ R ++++ E+++ +Y+ I
Sbjct: 255 LSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHLYDNI 311
>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
Length = 771
Score = 84.7 bits (208), Expect = 7e-16
Identities = 47/150 (31%), Positives = 80/150 (53%), Gaps = 2/150 (1%)
Query: 678 IAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPG 737
+A+ L+ E V LG + F++ V Y+ DF ALRTFL+ F L G
Sbjct: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376
Query: 738 EAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 797
E Q+ +R++ F+ RY +CN + S D + L ++++L TDLH + KM+ +Q+
Sbjct: 377 ETQERERVLTHFSRRYCQCNPDDS--TSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQF 434
Query: 798 IKMNRGINDSKDLPEEYLSSIYEEIEGKKI 827
I +ND +D ++ L ++Y I+ +K+
Sbjct: 435 IANLDQLNDGQDFAKDLLKTLYNSIKNEKL 464
>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
Length = 1024
Score = 82.4 bits (202), Expect = 4e-15
Identities = 47/154 (30%), Positives = 79/154 (51%), Gaps = 2/154 (1%)
Query: 674 SVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGF 733
+ + +A+ L++ + V LG + F+K V Y+ F ALR FL+
Sbjct: 557 AAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKEL 616
Query: 734 RLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMT 793
L GE Q+ +R++ F+ RY +CN +S D A+ L ++++L TDLH + +MT
Sbjct: 617 ALMGETQERERVLAHFSQRYFQCNP--EALSSEDGAHTLTCALMLLNTDLHGHNIGKRMT 674
Query: 794 KEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKI 827
+I G+ND D P E L ++Y I+ +K+
Sbjct: 675 CGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKL 708
>gi|114326552 MON2 homolog [Homo sapiens]
Length = 1717
Score = 79.0 bits (193), Expect = 4e-14
Identities = 97/462 (20%), Positives = 184/462 (39%), Gaps = 71/462 (15%)
Query: 963 MKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGRERE 1022
+ KNI ++TL+ +AH G LG SW +L + L ++ G
Sbjct: 672 LTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLV------------WILGLKPSSG 719
Query: 1023 GSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRL 1082
G+LK G V G ++ + T + + R+F S L
Sbjct: 720 GALKP-------------GRAVEGP------STVLTTAVMTDLPVISNILSRLFESSQYL 760
Query: 1083 DGNAIVDFVRWLCAVSMDELASPH----HPRMFSLQKIVEISYYNMNRIRLQWSRIWHVI 1138
D ++ + LC++S++ + + P +F++ K++E NM+RI + +W +
Sbjct: 761 DDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEI----LWRPL 816
Query: 1139 GDHFNKVGCNPNEDVAIFAVDSLRQL---SMKFLEKGELA-NFRFQKDFLRPFEHIMKKN 1194
H +V +PN + + ++L L + F L+ N R Q L P + + N
Sbjct: 817 TGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNIN 876
Query: 1195 RSPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTT 1254
P IR + C+ Q++ SQ ++ GW + V +D +++ AFQ +V T
Sbjct: 877 H-PDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQ-CLQLVVT 934
Query: 1255 IFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVL------ 1308
F P Q V F + + S+ +I L+ Y +R +
Sbjct: 935 DFLPTMPCT--CLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNK 992
Query: 1309 ----QEYTSDDMNVA---------PGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVM 1355
Q+ +++ V P D +W+ + L EL C+ R VR +
Sbjct: 993 EEAAQQKQAEEKGVVLNRPFHPAPPFDCLWL-CLYAKLGEL-CVDPRPA--VRKSAGQTL 1048
Query: 1356 FEIMKSYGHTFEKHWWQD-LFRIVFRIFDNMKLPEQLSEKSE 1396
F + ++G + W +++++F + D ++ ++K +
Sbjct: 1049 FSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEK 1090
Score = 47.8 bits (112), Expect = 1e-04
Identities = 32/142 (22%), Positives = 67/142 (47%), Gaps = 16/142 (11%)
Query: 71 PFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQ 130
PF + C +K P++ L +Q+L+++ ++ A + I+ + +
Sbjct: 70 PFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGN----------IINMLWQLMEN-S 118
Query: 131 TDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQML 190
+E LQ + LLT T +H+ + + + C+ ++ N+ N T A AT+ Q++
Sbjct: 119 LEELKLLQTVLVLLTTNTV----VHDEALSKAIVLCFRLHFTKDNITNNTAA-ATVRQVV 173
Query: 191 NVIFTRMENQVLQEARELEKPI 212
V+F RM + + +E+P+
Sbjct: 174 TVVFERMVAEDERHRDIIEQPV 195
Score = 47.8 bits (112), Expect = 1e-04
Identities = 45/188 (23%), Positives = 81/188 (43%), Gaps = 20/188 (10%)
Query: 372 KDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINA 431
KDA+++F+ LC+L + P ++ L+LL SVL + VF H+ F
Sbjct: 214 KDAYMLFQDLCQLVN---ADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFL 270
Query: 432 IKQYLCVALSK-----------NGVSSVPDVFELS-LAIFLTLLSNFKMHLKMQIEVFFK 479
+K+ +C + K + SS P E I + LL + +K +
Sbjct: 271 LKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVT 330
Query: 480 E--IFLNILETSTSSFEHRWM---VIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLV 534
E IFL++L + + +W+ ++++ R C Q + +YD ++ +F +V
Sbjct: 331 ECEIFLSLLVKFLDADKPQWLRAVAVESIHRFCVQPQLLRSFCQSYDMKQHSTKVFRDIV 390
Query: 535 NDLSKIAQ 542
N L Q
Sbjct: 391 NALGSFIQ 398
>gi|224593754 AXIN1 up-regulated 1 [Homo sapiens]
Length = 589
Score = 35.0 bits (79), Expect = 0.65
Identities = 43/159 (27%), Positives = 61/159 (38%), Gaps = 10/159 (6%)
Query: 193 IFTRMENQVLQEA---RELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTD 249
I T Q+ QEA RELE P Q P SP A+ P F K +D
Sbjct: 294 IHTLTRLQLEQEAESFRELEAPAQGSPPSP--GEEALVPTFPLAKPPMNNELGDNSCSSD 351
Query: 250 LTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHG 309
+T+ A S S ++E D P G G G + D L +++ + + +
Sbjct: 352 MTDSSTA-SSSASGTSEAPDCPTHPGLPGPGFQPGVDD---DSLARILSFSDSDFGGEEE 407
Query: 310 LTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLS 348
E E +G L+ C P + S G+A S S
Sbjct: 408 -EEEEGSVGNLDNLSCFHPADIFGTSDPGGLASWTHSYS 445
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 34.3 bits (77), Expect = 1.1
Identities = 25/102 (24%), Positives = 48/102 (47%), Gaps = 8/102 (7%)
Query: 776 IIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKEL 835
I + DL + + EQY K+++ +N+ K EE L Y E++ KK ++ +
Sbjct: 413 IAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEE-LDRKYYEVKNKKDELQSERNY 471
Query: 836 TIATKSTKQNVASEKQRRLLYNLEMEQM---AKTAKALMEAV 874
++ +Q + K+ +LE +Q A T KA++ +
Sbjct: 472 LWREENAEQQALAAKRE----DLEKKQQLLRAATGKAILNGI 509
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 33.9 bits (76), Expect = 1.5
Identities = 85/382 (22%), Positives = 144/382 (37%), Gaps = 80/382 (20%)
Query: 531 ERLVNDLSKIAQGRSGHELGMTPLQE-----------LSLRKKGLECLVSILKCMVEWSK 579
E N ++I R H + L E L K+GLE L C V+ +
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 580 DLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEV 639
+ H+ K LD V + + VS G + V E E
Sbjct: 1245 QVKAESEHKR---------------KKLD----AQVQELHAKVSEGDRLRV----ELAEK 1281
Query: 640 IKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQ--------------- 684
+ + +++ L + K+GI+F ++ L + ++D + L +
Sbjct: 1282 ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341
Query: 685 EERLDSTQVGDFLGDSARFNKE-VMYAYVDQLDFCEKEFVSALRTFLEGF-----RLPGE 738
EE +S Q + AR N E + A QL +K+ L T +E +L +
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGT-IESLEEAKKKLLKD 1400
Query: 739 AQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDL-HSPQVKNKMTKEQY 797
A+ + + +E+ A Y + + T L + LT DL H QV + + K+Q
Sbjct: 1401 AEALSQRLEEKALAYDKLEK---------TKNRLQQELDDLTVDLDHQRQVASNLEKKQK 1451
Query: 798 IKMNRGINDSKDLPEEYLSS-IYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLY 856
K ++ + + K + Y E E ++ KETK L++A + A E
Sbjct: 1452 -KFDQLLAEEKSISARYAEERDRAEAEARE---KETKALSLARALEEALEAKE------- 1500
Query: 857 NLEMEQMAKTAKALMEAVSHAK 878
E E+ K +A ME + +K
Sbjct: 1501 --EFERQNKQLRADMEDLMSSK 1520
>gi|6912702 transcription factor EC isoform a [Homo sapiens]
Length = 347
Score = 33.9 bits (76), Expect = 1.5
Identities = 33/136 (24%), Positives = 53/136 (38%), Gaps = 15/136 (11%)
Query: 240 SKPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVV-- 297
S+P P L H DS TEN P + ++ DD AQ ++D++ED++
Sbjct: 15 SQPAVPSGGPLVQHAHTTLDSDAGLTEN---PLTKLLAIGKEDDNAQWHMEDVIEDIIGM 71
Query: 298 TSAIKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDA 357
S+ KE L + G + +D S GI+ L+SA S
Sbjct: 72 ESSFKEEGADSPLLMQRTLSGSI----------LDVYSGEQGISPINMGLTSASCPSSLP 121
Query: 358 QGHQVAARFSHVLQKD 373
++ + L K+
Sbjct: 122 MKREITETDTRALAKE 137
>gi|214831834 transmembrane protein 169 [Homo sapiens]
Length = 297
Score = 33.1 bits (74), Expect = 2.5
Identities = 33/137 (24%), Positives = 54/137 (39%), Gaps = 9/137 (6%)
Query: 195 TRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGE 254
T +E QV +L P Q + V A A+ + + H + + K + PE + +
Sbjct: 5 TAVEGQV-----QLPSPHQGSLRKAVAAALALDGEST-MGHRKKKRKESRPESIIIYRSD 58
Query: 255 HARSDSGKVSTENGDAPR-ERGSSLSG--TDDGAQEVVKDILEDVVTSAIKEAAEKHGLT 311
+ ++D +E GD P+ E G DD + D +T I +K +
Sbjct: 59 NEKTDEEPGESEGGDQPKEEEGDDFLDYPVDDDMWNLPLDSRYVTLTGTITRGKKKGQMV 118
Query: 312 EPERVLGELECQECAIP 328
+ L E E QE P
Sbjct: 119 DIHVTLTEKELQELTKP 135
>gi|19923913 transmembrane protein 169 [Homo sapiens]
Length = 297
Score = 33.1 bits (74), Expect = 2.5
Identities = 33/137 (24%), Positives = 54/137 (39%), Gaps = 9/137 (6%)
Query: 195 TRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGE 254
T +E QV +L P Q + V A A+ + + H + + K + PE + +
Sbjct: 5 TAVEGQV-----QLPSPHQGSLRKAVAAALALDGEST-MGHRKKKRKESRPESIIIYRSD 58
Query: 255 HARSDSGKVSTENGDAPR-ERGSSLSG--TDDGAQEVVKDILEDVVTSAIKEAAEKHGLT 311
+ ++D +E GD P+ E G DD + D +T I +K +
Sbjct: 59 NEKTDEEPGESEGGDQPKEEEGDDFLDYPVDDDMWNLPLDSRYVTLTGTITRGKKKGQMV 118
Query: 312 EPERVLGELECQECAIP 328
+ L E E QE P
Sbjct: 119 DIHVTLTEKELQELTKP 135
>gi|214831799 transmembrane protein 169 [Homo sapiens]
Length = 297
Score = 33.1 bits (74), Expect = 2.5
Identities = 33/137 (24%), Positives = 54/137 (39%), Gaps = 9/137 (6%)
Query: 195 TRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGE 254
T +E QV +L P Q + V A A+ + + H + + K + PE + +
Sbjct: 5 TAVEGQV-----QLPSPHQGSLRKAVAAALALDGEST-MGHRKKKRKESRPESIIIYRSD 58
Query: 255 HARSDSGKVSTENGDAPR-ERGSSLSG--TDDGAQEVVKDILEDVVTSAIKEAAEKHGLT 311
+ ++D +E GD P+ E G DD + D +T I +K +
Sbjct: 59 NEKTDEEPGESEGGDQPKEEEGDDFLDYPVDDDMWNLPLDSRYVTLTGTITRGKKKGQMV 118
Query: 312 EPERVLGELECQECAIP 328
+ L E E QE P
Sbjct: 119 DIHVTLTEKELQELTKP 135
>gi|214831780 transmembrane protein 169 [Homo sapiens]
Length = 297
Score = 33.1 bits (74), Expect = 2.5
Identities = 33/137 (24%), Positives = 54/137 (39%), Gaps = 9/137 (6%)
Query: 195 TRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGE 254
T +E QV +L P Q + V A A+ + + H + + K + PE + +
Sbjct: 5 TAVEGQV-----QLPSPHQGSLRKAVAAALALDGEST-MGHRKKKRKESRPESIIIYRSD 58
Query: 255 HARSDSGKVSTENGDAPR-ERGSSLSG--TDDGAQEVVKDILEDVVTSAIKEAAEKHGLT 311
+ ++D +E GD P+ E G DD + D +T I +K +
Sbjct: 59 NEKTDEEPGESEGGDQPKEEEGDDFLDYPVDDDMWNLPLDSRYVTLTGTITRGKKKGQMV 118
Query: 312 EPERVLGELECQECAIP 328
+ L E E QE P
Sbjct: 119 DIHVTLTEKELQELTKP 135
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,648,177
Number of Sequences: 37866
Number of extensions: 2724846
Number of successful extensions: 7612
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 7501
Number of HSP's gapped (non-prelim): 79
length of query: 1785
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1668
effective length of database: 13,817,196
effective search space: 23047082928
effective search space used: 23047082928
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.