Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 150417975
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo
sapiens]
(580 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 1180 0.0
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 1108 0.0
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 461 e-129
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 430 e-120
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 430 e-120
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 231 1e-60
gi|148529025 pleckstrin homology domain containing, family G (wi... 197 2e-50
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 192 7e-49
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 192 7e-49
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 184 3e-46
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 184 3e-46
gi|193211603 pleckstrin homology domain containing, family G (wi... 175 9e-44
gi|193211598 pleckstrin homology domain containing, family G (wi... 175 9e-44
gi|193211596 pleckstrin homology domain containing, family G (wi... 175 9e-44
gi|193211594 pleckstrin homology domain containing, family G (wi... 175 9e-44
gi|55742734 pleckstrin homology domain containing, family G (wit... 175 9e-44
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 156 4e-38
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 126 5e-29
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 126 5e-29
gi|71274148 pleckstrin homology domain containing, family G (wit... 113 5e-25
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 113 5e-25
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 104 2e-22
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 84 4e-16
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 84 4e-16
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 77 3e-14
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 77 4e-14
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 76 1e-13
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 75 2e-13
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 74 4e-13
gi|24797153 faciogenital dysplasia protein [Homo sapiens] 72 1e-12
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo
sapiens]
Length = 580
Score = 1180 bits (3052), Expect = 0.0
Identities = 580/580 (100%), Positives = 580/580 (100%)
Query: 1 MRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSS 60
MRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSS
Sbjct: 1 MRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSS 60
Query: 61 GLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPE 120
GLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPE
Sbjct: 61 GLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPE 120
Query: 121 LTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLG 180
LTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLG
Sbjct: 121 LTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLG 180
Query: 181 QIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI 240
QIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI
Sbjct: 181 QIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI 240
Query: 241 KHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQL 300
KHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQL
Sbjct: 241 KHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQL 300
Query: 301 LLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDT 360
LLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDT
Sbjct: 301 LLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDT 360
Query: 361 FWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLE 420
FWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLE
Sbjct: 361 FWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLE 420
Query: 421 GNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIE 480
GNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIE
Sbjct: 421 GNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIE 480
Query: 481 YQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLP 540
YQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLP
Sbjct: 481 YQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLP 540
Query: 541 LDKQALGDIPQAPHDSPPVSPTPKTPPCQARLAKLDEDEL 580
LDKQALGDIPQAPHDSPPVSPTPKTPPCQARLAKLDEDEL
Sbjct: 541 LDKQALGDIPQAPHDSPPVSPTPKTPPCQARLAKLDEDEL 580
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo
sapiens]
Length = 619
Score = 1108 bits (2866), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 33 ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE 92
ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE
Sbjct: 72 ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE 131
Query: 93 TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE 152
TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE
Sbjct: 132 TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE 191
Query: 153 QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ 212
QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ
Sbjct: 192 QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ 251
Query: 213 IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE 272
IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE
Sbjct: 252 IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE 311
Query: 273 ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR 332
ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR
Sbjct: 312 ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR 371
Query: 333 CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE 392
CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE
Sbjct: 372 CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE 431
Query: 393 ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA 452
ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA
Sbjct: 432 ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA 491
Query: 453 ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ 512
ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ
Sbjct: 492 ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ 551
Query: 513 GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL 572
GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL
Sbjct: 552 GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL 611
Query: 573 AKLDEDEL 580
AKLDEDEL
Sbjct: 612 AKLDEDEL 619
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 461 bits (1185), Expect = e-129
Identities = 249/456 (54%), Positives = 322/456 (70%), Gaps = 18/456 (3%)
Query: 125 TTLLEGPGDKTQP---PEEETL--SQAPESE-EEQKKKALERSMYVLSELVETEKMYVDD 178
++LL GD + P P + +L S +P E EE+K +L+R YVL ELVETE+ YV D
Sbjct: 1928 SSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRD 1987
Query: 179 LGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQL 238
LG +VEGYMA M GVP+ ++G+D+IVFGNI QIY+WHRD+FL EL++CL+DP+ L L
Sbjct: 1988 LGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSL 2047
Query: 239 FIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKY 298
F+KHERRLHMY+ YCQNKPKSEH+VSE+ D++FE+L+Q+LGHRLQL DLLIKPVQRIMKY
Sbjct: 2048 FVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKY 2107
Query: 299 QLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQ 358
QLLLKDFLKY +A +DT++LE+AVEVMC VP+RCNDMM +GRL+GF+GK+ AQGKLL Q
Sbjct: 2108 QLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQ 2167
Query: 359 DTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLG 418
DTF VT+ +AG L R RERR+FLFEQI+IFSE L +G + PG+++KNSIKVSCL
Sbjct: 2168 DTFLVTDQDAG--LLPRCRERRIFLFEQIVIFSEPL-DKKKGFSMPGFLFKNSIKVSCLC 2224
Query: 419 LEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSP 478
LE N++ DPC+FALTSR + ++ ++L ++ P++ Q WI + QILE+QR+FLNAL SP
Sbjct: 2225 LEENVENDPCKFALTSRTGD-VVETFILHSSSPSVRQTWIHEINQILENQRNFLNALTSP 2283
Query: 479 IEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHT--PIN-GSLPSLLLSPKGEVA 535
IEYQR S G G G G G G + GS H+ P + G PS S +
Sbjct: 2284 IEYQRNHSGGGGGGGSGGSG-GGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSRIP 2342
Query: 536 RALL----PLDKQALGDIPQAPHDSPPVSPTPKTPP 567
+ + L A +A S +P P PP
Sbjct: 2343 QPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPP 2378
Score = 236 bits (601), Expect = 6e-62
Identities = 131/370 (35%), Positives = 212/370 (57%), Gaps = 12/370 (3%)
Query: 137 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQG 194
P E L A E+K+K+ R ++++EL++TEK YV DL + ++ Y+ T +
Sbjct: 1269 PGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEE 1328
Query: 195 VPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQ 254
+P + ++ I+FGN+Q+IYE+H + FL+EL++ + P+ + F+ + MYV YC+
Sbjct: 1329 IPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCK 1388
Query: 255 NKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGM 314
NKP S ++ E SYF+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 1389 NKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG-- 1446
Query: 315 DTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSS 374
+++ +EVM VPKR ND M L L GF+ + +QG+L+ Q++F V +P+ L
Sbjct: 1447 -KGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKT---LIR 1502
Query: 375 RGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTS 434
+GRER +FLFE ++FS+ + + Y+YK+ + S LG+ +++GDPC+FAL
Sbjct: 1503 KGRERHLFLFEMSLVFSKEVKD---SSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWV 1559
Query: 435 RGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEYQRRESQTNSLGR 493
+ VL+A+ Q WIKH+ ++++ + L AL+ PI + T GR
Sbjct: 1560 GRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGR 1619
Query: 494 PRGPGVGSPG 503
G + S G
Sbjct: 1620 RDGEDLDSQG 1629
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 430 bits (1106), Expect = e-120
Identities = 212/339 (62%), Positives = 274/339 (80%), Gaps = 9/339 (2%)
Query: 150 EEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGN 209
EEEQK KAL M+VL+ELV+TEK YV DLG +VEG+M + +GVPE +RG+D+IVFGN
Sbjct: 1919 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGN 1978
Query: 210 IQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS 269
I QIY+WH+D+FL EL++C+++ D LAQLFIKHER+LH+YV YCQNKP+SE++V+E+ D+
Sbjct: 1979 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 2037
Query: 270 YFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFV 329
YFEE++Q++ RL L+D LIKP+QRI KYQLLLKDFL+Y +AG++ +D+E+AVE+MC V
Sbjct: 2038 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097
Query: 330 PKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIII 389
PKRCNDMM LGRL+GFEG LTAQGKLL QDTF+V E +AG + SR +ERRVFLFEQI+I
Sbjct: 2098 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAG--MQSRTKERRVFLFEQIVI 2155
Query: 390 FSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAA 449
FSE L +G PGY++K SIK++ L LE N+ DPC+FAL +R +R VLQAA
Sbjct: 2156 FSELLR---KGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETS---ERVVLQAA 2209
Query: 450 DPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQT 488
+ I QAW++ + Q+LE+QRDFLNALQSPIEYQR+E T
Sbjct: 2210 NADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERST 2248
Score = 231 bits (589), Expect = 1e-60
Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%)
Query: 140 EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 197
E L A E+K+K+ + ++++EL++TEK YV DL + +E Y+ T + +P
Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
Query: 198 SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 257
+ ++ I+FGNIQ+IY++H + FL+EL++ + P+ + F+ + MYV YC+NKP
Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
Query: 258 KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 317
S ++ E ++F+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437
Query: 318 DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 377
+L+ +EVM VPK+ ND M + L GF+ L QG+L+ QD F V +P++ L +GR
Sbjct: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494
Query: 378 ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 437
ER +FLFE ++FS+ + G T+ YVYKN + S LG+ +++GDPC+FAL S
Sbjct: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551
Query: 438 EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 490
+ VL+A++ Q WIK++ ++++ + L AL+ P++ QR S+ +
Sbjct: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611
Query: 491 LG--RPRGPGVGSPGRIRLGDQAQGST 515
+ +G G P I + + +T
Sbjct: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638
Score = 30.0 bits (66), Expect = 6.1
Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 6/58 (10%)
Query: 26 CFARGGRESYSIAGSE-GSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWL 82
CF +++YS + SE G S S A+ A PS L+S SPGP + L++WL
Sbjct: 1719 CFFPLVKDAYSHSSSENGGKSESVANLQAQPS-----LNSIHSSPGPKRSTNTLKKWL 1771
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 430 bits (1106), Expect = e-120
Identities = 212/339 (62%), Positives = 274/339 (80%), Gaps = 9/339 (2%)
Query: 150 EEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGN 209
EEEQK KAL M+VL+ELV+TEK YV DLG +VEG+M + +GVPE +RG+D+IVFGN
Sbjct: 222 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGN 281
Query: 210 IQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS 269
I QIY+WH+D+FL EL++C+++ D LAQLFIKHER+LH+YV YCQNKP+SE++V+E+ D+
Sbjct: 282 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 340
Query: 270 YFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFV 329
YFEE++Q++ RL L+D LIKP+QRI KYQLLLKDFL+Y +AG++ +D+E+AVE+MC V
Sbjct: 341 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 400
Query: 330 PKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIII 389
PKRCNDMM LGRL+GFEG LTAQGKLL QDTF+V E +AG + SR +ERRVFLFEQI+I
Sbjct: 401 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAG--MQSRTKERRVFLFEQIVI 458
Query: 390 FSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAA 449
FSE L +G PGY++K SIK++ L LE N+ DPC+FAL +R +R VLQAA
Sbjct: 459 FSELLR---KGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETS---ERVVLQAA 512
Query: 450 DPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQT 488
+ I QAW++ + Q+LE+QRDFLNALQSPIEYQR+E T
Sbjct: 513 NADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERST 551
Score = 38.5 bits (88), Expect = 0.017
Identities = 27/65 (41%), Positives = 36/65 (55%), Gaps = 8/65 (12%)
Query: 19 VLAKCGCCFARGGRESYSIAGSE-GSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSG 77
+ AKC CCF R++YS + SE G S S A+ A PS L+S SPGP +
Sbjct: 17 LFAKCCCCFPC--RDAYSHSSSENGGKSESVANLQAQPS-----LNSIHSSPGPKRSTNT 69
Query: 78 LRRWL 82
L++WL
Sbjct: 70 LKKWL 74
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 231 bits (589), Expect = 1e-60
Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%)
Query: 140 EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 197
E L A E+K+K+ + ++++EL++TEK YV DL + +E Y+ T + +P
Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
Query: 198 SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 257
+ ++ I+FGNIQ+IY++H + FL+EL++ + P+ + F+ + MYV YC+NKP
Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
Query: 258 KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 317
S ++ E ++F+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437
Query: 318 DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 377
+L+ +EVM VPK+ ND M + L GF+ L QG+L+ QD F V +P++ L +GR
Sbjct: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494
Query: 378 ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 437
ER +FLFE ++FS+ + G T+ YVYKN + S LG+ +++GDPC+FAL S
Sbjct: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551
Query: 438 EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 490
+ VL+A++ Q WIK++ ++++ + L AL+ P++ QR S+ +
Sbjct: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611
Query: 491 LG--RPRGPGVGSPGRIRLGDQAQGST 515
+ +G G P I + + +T
Sbjct: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 197 bits (501), Expect = 2e-50
Identities = 115/375 (30%), Positives = 204/375 (54%), Gaps = 21/375 (5%)
Query: 147 PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIV 206
P E+ +++ R ++++E++ TE+ Y+ LG +++ Y M +P+ LRG+ ++
Sbjct: 792 PAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHHVI 851
Query: 207 FGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEF 266
FGN+++++++H+ +FL+EL+RC P + + F++HE + MYV+Y +NKP+S+ ++S
Sbjct: 852 FGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSH 911
Query: 267 GDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYN---RAGMDTADLEQAV 323
G+++F++ +++LG ++ L L++PVQR+ KY LLL+D LK + G + +L A
Sbjct: 912 GNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAE 971
Query: 324 EVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 383
V+CF + ND++ + +RG + L QG+L +D F V + R VFL
Sbjct: 972 VVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV-------CCGRKKYLRHVFL 1024
Query: 384 FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQR 443
FE +I+FS+ G+ Y+YK S K + +G+ N+ RF + R
Sbjct: 1025 FEDLILFSKT---QKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDT 1081
Query: 444 YVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPG 503
Y+LQA+ + AW + +IL Q AL+S + R + S+G P +
Sbjct: 1082 YILQASSAEVKSAWTDVIGRILWRQ-----ALKS---RELRIQEMASMGIGNQPFMDVKP 1133
Query: 504 RIRLGDQAQGSTHTP 518
R R D A S P
Sbjct: 1134 RDRTPDCAVISDRAP 1148
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 192 bits (488), Expect = 7e-49
Identities = 128/390 (32%), Positives = 211/390 (54%), Gaps = 22/390 (5%)
Query: 127 LLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGY 186
L GP + + E+ + EE++ A+ R +V+SEL++TE+ YV++L ++EGY
Sbjct: 626 LRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR-HVMSELLDTERAYVEELLCVLEGY 684
Query: 187 MATM----AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKH 242
A M A + L + ++FGN+++IY +H FL+EL+ P+ + + F++
Sbjct: 685 AAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLER 744
Query: 243 ERRLHMYVVYCQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 301
+Y YCQNKP+SE + + D +F+E +++L H+L L+ L+KPVQRI KYQLL
Sbjct: 745 MEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLL 804
Query: 302 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF 361
LK+ LK Y+R DL++A+ + + K ND M L + G++G L GKLL Q +F
Sbjct: 805 LKEMLK-YSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSF 863
Query: 362 WVTEPEAGG------LLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQ-PGYVYKNSIKV 414
V G L + +R +FL E+ ++F + G + P Y YK S+ +
Sbjct: 864 SVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNM 923
Query: 415 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 474
+ +G+ N++GD +F + E + Y++QA P I AW+ + ++L SQ L A
Sbjct: 924 AAVGITENVKGDAKKFEIWYNARE---EVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQA 977
Query: 475 LQSPIEYQRRESQTNSLGRPRGPGVGSPGR 504
+ +++ E Q+ SL P P SP R
Sbjct: 978 CREASQHRALE-QSQSLPLP-APTSTSPSR 1005
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 192 bits (488), Expect = 7e-49
Identities = 128/390 (32%), Positives = 211/390 (54%), Gaps = 22/390 (5%)
Query: 127 LLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGY 186
L GP + + E+ + EE++ A+ R +V+SEL++TE+ YV++L ++EGY
Sbjct: 573 LRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR-HVMSELLDTERAYVEELLCVLEGY 631
Query: 187 MATM----AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKH 242
A M A + L + ++FGN+++IY +H FL+EL+ P+ + + F++
Sbjct: 632 AAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLER 691
Query: 243 ERRLHMYVVYCQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 301
+Y YCQNKP+SE + + D +F+E +++L H+L L+ L+KPVQRI KYQLL
Sbjct: 692 MEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLL 751
Query: 302 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF 361
LK+ LK Y+R DL++A+ + + K ND M L + G++G L GKLL Q +F
Sbjct: 752 LKEMLK-YSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSF 810
Query: 362 WVTEPEAGG------LLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQ-PGYVYKNSIKV 414
V G L + +R +FL E+ ++F + G + P Y YK S+ +
Sbjct: 811 SVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNM 870
Query: 415 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 474
+ +G+ N++GD +F + E + Y++QA P I AW+ + ++L SQ L A
Sbjct: 871 AAVGITENVKGDAKKFEIWYNARE---EVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQA 924
Query: 475 LQSPIEYQRRESQTNSLGRPRGPGVGSPGR 504
+ +++ E Q+ SL P P SP R
Sbjct: 925 CREASQHRALE-QSQSLPLP-APTSTSPSR 952
>gi|153791628 MCF.2 cell line derived transforming sequence isoform
a [Homo sapiens]
Length = 985
Score = 184 bits (466), Expect = 3e-46
Identities = 112/348 (32%), Positives = 190/348 (54%), Gaps = 16/348 (4%)
Query: 137 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGV- 195
P +E S P S + +VL+EL++TE++YV +L ++ GY A M +
Sbjct: 532 PDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMF 591
Query: 196 ---PESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVY 252
P LR + I+FGN+ +IYE+H D FL L+ C P+ + F++ + MY Y
Sbjct: 592 DLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKY 651
Query: 253 CQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 311
CQNKP+SE + ++ + ++F+E +++L HRL+L+ L+KPVQRI KYQLLLK+ LK Y++
Sbjct: 652 CQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-YSK 710
Query: 312 AGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF--WVTEPEAG 369
+A L++A++ M + K ND M + G+ G L GK++ Q F W+ +
Sbjct: 711 DCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGA 770
Query: 370 GLLSSRGR----ERRVFLFEQIIIF-SEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQ 424
+ R +R +FL+E+ I+F + G P Y +K+ K+ +G+ ++
Sbjct: 771 TKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVK 830
Query: 425 GDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL 472
GD +F + E + Y++QA++ + W+K + IL Q++ L
Sbjct: 831 GDNRKFEIWYGEKE---EVYIVQASNVDVKMTWLKEIRNILLKQQELL 875
>gi|153791325 MCF.2 cell line derived transforming sequence isoform
b [Homo sapiens]
Length = 925
Score = 184 bits (466), Expect = 3e-46
Identities = 112/348 (32%), Positives = 190/348 (54%), Gaps = 16/348 (4%)
Query: 137 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGV- 195
P +E S P S + +VL+EL++TE++YV +L ++ GY A M +
Sbjct: 472 PDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMF 531
Query: 196 ---PESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVY 252
P LR + I+FGN+ +IYE+H D FL L+ C P+ + F++ + MY Y
Sbjct: 532 DLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKY 591
Query: 253 CQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 311
CQNKP+SE + ++ + ++F+E +++L HRL+L+ L+KPVQRI KYQLLLK+ LK Y++
Sbjct: 592 CQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-YSK 650
Query: 312 AGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF--WVTEPEAG 369
+A L++A++ M + K ND M + G+ G L GK++ Q F W+ +
Sbjct: 651 DCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGA 710
Query: 370 GLLSSRGR----ERRVFLFEQIIIF-SEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQ 424
+ R +R +FL+E+ I+F + G P Y +K+ K+ +G+ ++
Sbjct: 711 TKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVK 770
Query: 425 GDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL 472
GD +F + E + Y++QA++ + W+K + IL Q++ L
Sbjct: 771 GDNRKFEIWYGEKE---EVYIVQASNVDVKMTWLKEIRNILLKQQELL 815
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 175 bits (444), Expect = 9e-44
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 706
Query: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 707 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 766
Query: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 767 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 826
Query: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 827 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 879
Query: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 880 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 935
Query: 456 AWIKHVAQILESQ 468
AW ++ +L Q
Sbjct: 936 AWTADISHLLWRQ 948
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 175 bits (444), Expect = 9e-44
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787
Query: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847
Query: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960
Query: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016
Query: 456 AWIKHVAQILESQ 468
AW ++ +L Q
Sbjct: 1017 AWTADISHLLWRQ 1029
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 175 bits (444), Expect = 9e-44
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787
Query: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847
Query: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960
Query: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016
Query: 456 AWIKHVAQILESQ 468
AW ++ +L Q
Sbjct: 1017 AWTADISHLLWRQ 1029
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 175 bits (444), Expect = 9e-44
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787
Query: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847
Query: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960
Query: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016
Query: 456 AWIKHVAQILESQ 468
AW ++ +L Q
Sbjct: 1017 AWTADISHLLWRQ 1029
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 175 bits (444), Expect = 9e-44
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787
Query: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847
Query: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960
Query: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016
Query: 456 AWIKHVAQILESQ 468
AW ++ +L Q
Sbjct: 1017 AWTADISHLLWRQ 1029
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 156 bits (395), Expect = 4e-38
Identities = 108/407 (26%), Positives = 198/407 (48%), Gaps = 38/407 (9%)
Query: 147 PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM----AAQGVPESLRGR 202
PE E++ + L ++ +L+ETE++Y+ ++ I++GY+ M +P+ L+
Sbjct: 606 PELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNN 665
Query: 203 DRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHV 262
+FGNI+++YE+H FL+EL++C ++P+ LA F+K + L +Y Y +N P++ +
Sbjct: 666 KDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAI 725
Query: 263 VSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMD------ 315
E D +YF ++QL H L L L P QR++KYQ+LLK L + + M+
Sbjct: 726 WQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGEL 785
Query: 316 ----------------TADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLL--G 357
+ +L+QA+ V+ + K C + L + + GKLL G
Sbjct: 786 GGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHG 845
Query: 358 QDTFWVTEPE---AGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKV 414
+ W + L+ + +R+++LFE+ I+F + G P Y +K ++K+
Sbjct: 846 PFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKL 905
Query: 415 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 474
L + +G +F + SR G+++Y+LQAA I W ++++L Q++ +
Sbjct: 906 MTLSIRQLGRGSHRKFEIASR---NGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKD 962
Query: 475 LQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPING 521
+P Q S + G GP + + R + S+ I G
Sbjct: 963 QGNP---QFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKG 1006
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 126 bits (317), Expect = 5e-29
Identities = 99/338 (29%), Positives = 168/338 (49%), Gaps = 27/338 (7%)
Query: 144 SQAPE------SEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMA-AQGVP 196
++APE SE+E K R V+ EL+ +E+ +V++L + ++ + VP
Sbjct: 5675 AEAPEFPGEAVSEDEYKA----RLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVP 5730
Query: 197 ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNK 256
++ G+ ++F N++ I +H FLQELQ+C D D +A FIK++ Y+ + +
Sbjct: 5731 IAVAGQKAVIFRNVRDIGRFHSS-FLQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGR 5788
Query: 257 PKSEHVV-----SEFGDSYFEELRQQLGHRLQ-----LNDLLIKPVQRIMKYQLLLKDFL 306
++E VV EF Y EE G Q L L +PV+R+ +YQ LLK+ +
Sbjct: 5789 VQAESVVVSTAIQEFYKKYAEEALLA-GDPSQPPPPPLQHYLEQPVERVQRYQALLKELI 5847
Query: 307 KYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEP 366
+ R + A LEQA V+ +P+R + + + + + G L A G+ + Q F V E
Sbjct: 5848 RNKARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEG 5907
Query: 367 EAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGD 426
G + +G R VFLF ++ + R T YV++N +K+S + L ++GD
Sbjct: 5908 APGARMPWKGHNRHVFLFRNHLVICKPRRDS-RTDT-VSYVFRNMMKLSSIDLNDQVEGD 5965
Query: 427 PCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQI 464
F + E +++Y+LQA I +W+K + I
Sbjct: 5966 DRAFEVWQE-REDSVRKYLLQARTAIIKSSWVKEICGI 6002
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 126 bits (317), Expect = 5e-29
Identities = 99/338 (29%), Positives = 168/338 (49%), Gaps = 27/338 (7%)
Query: 144 SQAPE------SEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMA-AQGVP 196
++APE SE+E K R V+ EL+ +E+ +V++L + ++ + VP
Sbjct: 5675 AEAPEFPGEAVSEDEYKA----RLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVP 5730
Query: 197 ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNK 256
++ G+ ++F N++ I +H FLQELQ+C D D +A FIK++ Y+ + +
Sbjct: 5731 IAVAGQKAVIFRNVRDIGRFHSS-FLQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGR 5788
Query: 257 PKSEHVV-----SEFGDSYFEELRQQLGHRLQ-----LNDLLIKPVQRIMKYQLLLKDFL 306
++E VV EF Y EE G Q L L +PV+R+ +YQ LLK+ +
Sbjct: 5789 VQAESVVVSTAIQEFYKKYAEEALLA-GDPSQPPPPPLQHYLEQPVERVQRYQALLKELI 5847
Query: 307 KYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEP 366
+ R + A LEQA V+ +P+R + + + + + G L A G+ + Q F V E
Sbjct: 5848 RNKARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEG 5907
Query: 367 EAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGD 426
G + +G R VFLF ++ + R T YV++N +K+S + L ++GD
Sbjct: 5908 APGARMPWKGHNRHVFLFRNHLVICKPRRDS-RTDT-VSYVFRNMMKLSSIDLNDQVEGD 5965
Query: 427 PCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQI 464
F + E +++Y+LQA I +W+K + I
Sbjct: 5966 DRAFEVWQE-REDSVRKYLLQARTAIIKSSWVKEICGI 6002
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 113 bits (282), Expect = 5e-25
Identities = 91/321 (28%), Positives = 155/321 (48%), Gaps = 41/321 (12%)
Query: 164 VLSELVETEKMYVDDLGQIVEGYMATMAAQG-VPESLRGRDRIVFGNIQQIYEWHRDYFL 222
V+ E++ETE+ YV DL IVE Y+ + Q +P R + FGNIQ IY ++ + L
Sbjct: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSAL-FGNIQDIYHFNSE-LL 174
Query: 223 QELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSE-----FGDSYFEELRQQ 277
Q+L+ C DP +A+ F+ H+Y YC N P+S V++E +F E ++
Sbjct: 175 QDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQET 234
Query: 278 LGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMM 337
L H L L L+KPVQRI+KY LLL + + ++ + A++ M V NDM
Sbjct: 235 LKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMK 294
Query: 338 -----------TLGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFE 385
L ++G LT+ G+L+ + TF + + ER +FLF+
Sbjct: 295 RKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAK---------NERTLFLFD 345
Query: 386 QIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTS-RGPEGGIQRY 444
++++ ++ R T + YK I L L + +P F++ + P+ ++
Sbjct: 346 KLLLITKK-----RDDT---FTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPK---LQH 394
Query: 445 VLQAADPAISQAWIKHVAQIL 465
+QA + W+ H+ +++
Sbjct: 395 TVQAKSQQDKRLWVLHLKRLI 415
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 113 bits (282), Expect = 5e-25
Identities = 155/600 (25%), Positives = 240/600 (40%), Gaps = 97/600 (16%)
Query: 8 GRCA--CPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSSGLSSG 65
GRC C + R++ G Y ++G+ S A G P PS LSS
Sbjct: 939 GRCQARCQELERRIQQHVG---EEASPRGYRRRRADGASSGGAQWG---PRSPSPSLSSL 992
Query: 66 --PCSPGP-PGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELT 122
P SPGP P P HC D + GP L P E P
Sbjct: 993 LLPSSPGPRPAP-----------SHCSLAPCGEDYEEEGPE----LAPE---AEGRPPRA 1034
Query: 123 LLTTLLEGPG----DKTQPPEEETL---SQAPE------SEEEQKKKALERSMYVLSELV 169
+L LE D+T P E L ++ P+ + ++K+++ ++SEL+
Sbjct: 1035 VLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELI 1094
Query: 170 ETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCL 229
E+ YV L + V + PE LRG +++ +HR +FL+ELQ C
Sbjct: 1095 ACEQDYVATLSEPVP----PPGPELTPE-LRGTWAAALSARERLRSFHRTHFLRELQGCA 1149
Query: 230 KDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLI 289
P + F++H + +Y Y +++ K E+ ++ S + + G L L
Sbjct: 1150 THPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAAL--SPLSKGSMEAGP--YLPRALQ 1205
Query: 290 KPVQRIMKYQLLLKDFLKYYNRAGMDTAD----LEQAVEVMCFVPKRCNDMMTLGRLRGF 345
+P++++ +Y LL++ L+ AG + + L AV+++ R D++ + +RG
Sbjct: 1206 QPLEQLTRYGRLLEELLR---EAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGC 1262
Query: 346 EGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPG 405
E L QG+LL +D F V + + R VFLFE +++FS+ G GG++
Sbjct: 1263 EIDLKEQGQLLHRDPFTV-------ICGRKKCLRHVFLFEHLLLFSKL--KGPEGGSEM- 1312
Query: 406 YVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQIL 465
+VYK + K + +GL N+ F L R + Y LQA P I W +AQ+L
Sbjct: 1313 FVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAR-EAYTLQATSPEIKLKWTSSIAQLL 1371
Query: 466 ESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGV---------------GSPGRIRLGDQ 510
Q L R Q S+G P + G R R
Sbjct: 1372 WRQAAHNKEL--------RVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVA 1423
Query: 511 AQGSTHTPINGSLPSL---LLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPP 567
H SLP L S V LD + + P+ S VSP P+ P
Sbjct: 1424 VSSFEHA--GPSLPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSP 1481
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 104 bits (260), Expect = 2e-22
Identities = 114/376 (30%), Positives = 174/376 (46%), Gaps = 53/376 (14%)
Query: 164 VLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQ 223
V E+VETE+ YV DL IVE Y+ + GV + +F NI+ IYE+ + L+
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSE-LLE 164
Query: 224 ELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS-----YFEELRQQL 278
+L+ +A+ F++ +Y +YC N P S ++ E S + +E + QL
Sbjct: 165 DLENS-SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQL 223
Query: 279 GHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTAD---LEQAVEVMCFVPKRCND 335
H L L L+KPVQRI+KY LLL++ K++ G T +E+A+ M V ND
Sbjct: 224 RHSLPLQSFLLKPVQRILKYHLLLQELGKHW-AEGPGTGGREMVEEAIVSMTAVAWYIND 282
Query: 336 MM-----------TLGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 383
M RL G+ G +L+A G+L+ + F GG RG ER +FL
Sbjct: 283 MKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF---RGGGGGGPRLRGGERLLFL 339
Query: 384 FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRG-PEGGIQ 442
F ++++ ++ R G + Y YK I L + + + DP F ++ P+
Sbjct: 340 FSRMLLVAK------RRGLE--YTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPK---H 387
Query: 443 RYVLQAADPAISQAWI---------KHVAQILESQRDFL--NALQ-SPIEYQRRESQTNS 490
R++LQA + + WI H A I + L N+L +P E T
Sbjct: 388 RHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPP 447
Query: 491 LG--RPRGPGVGSPGR 504
LG RPR +PGR
Sbjct: 448 LGSPRPRDARSFTPGR 463
>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 84.0 bits (206), Expect = 4e-16
Identities = 97/390 (24%), Positives = 169/390 (43%), Gaps = 51/390 (13%)
Query: 38 AGSEGSISASAASGLAAPSGPSSGLSSGPCSP--GPPGPVSGLRRWLDHSKHCLSVETEA 95
+ S G + A A P S ++G SP GP G +SG + + S
Sbjct: 26 SSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPNRDSGIDS----P 81
Query: 96 DSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQP---PEEET---LSQAPES 149
S AG EN+ E L G P T+L E D P P+EE + + P+S
Sbjct: 82 SSSVAG--ENFPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQEEADSDVGEEPDS 136
Query: 150 EEEQKK----------KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVP-ES 198
E +K ++ +++ EL+ TE+ YV L + + + + G+P E
Sbjct: 137 ENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEV 196
Query: 199 LRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW-----LAQLFIKHERRLHMYVVYC 253
+ G +F NI I+ +H + L EL+ + + +W L + K L MY Y
Sbjct: 197 IMG----IFSNISSIHRFHGQFLLPELKTRITE-EWDTNPRLGDILQKLAPFLKMYGEYV 251
Query: 254 QNKPKSEHVVSE-------FGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFL 306
+N ++ +VS F D +Q++ L L +++PVQR+ +Y+LLLKD+L
Sbjct: 252 KNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYL 311
Query: 307 KYYNRAGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLTAQGKLLGQDTFW 362
K + D D E+++E++ N + + +L +L + ++
Sbjct: 312 KRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANEL 371
Query: 363 VTEPEAGGLLSSRG--RERRVFLFEQIIIF 390
+ E + L + G ++R +FLF +I++
Sbjct: 372 IKEGQIQKLSAKNGTPQDRHLFLFNSMILY 401
>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 84.0 bits (206), Expect = 4e-16
Identities = 97/390 (24%), Positives = 169/390 (43%), Gaps = 51/390 (13%)
Query: 38 AGSEGSISASAASGLAAPSGPSSGLSSGPCSP--GPPGPVSGLRRWLDHSKHCLSVETEA 95
+ S G + A A P S ++G SP GP G +SG + + S
Sbjct: 26 SSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPNRDSGIDS----P 81
Query: 96 DSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQP---PEEET---LSQAPES 149
S AG EN+ E L G P T+L E D P P+EE + + P+S
Sbjct: 82 SSSVAG--ENFPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQEEADSDVGEEPDS 136
Query: 150 EEEQKK----------KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVP-ES 198
E +K ++ +++ EL+ TE+ YV L + + + + G+P E
Sbjct: 137 ENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEV 196
Query: 199 LRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW-----LAQLFIKHERRLHMYVVYC 253
+ G +F NI I+ +H + L EL+ + + +W L + K L MY Y
Sbjct: 197 IMG----IFSNISSIHRFHGQFLLPELKTRITE-EWDTNPRLGDILQKLAPFLKMYGEYV 251
Query: 254 QNKPKSEHVVSE-------FGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFL 306
+N ++ +VS F D +Q++ L L +++PVQR+ +Y+LLLKD+L
Sbjct: 252 KNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYL 311
Query: 307 KYYNRAGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLTAQGKLLGQDTFW 362
K + D D E+++E++ N + + +L +L + ++
Sbjct: 312 KRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANEL 371
Query: 363 VTEPEAGGLLSSRG--RERRVFLFEQIIIF 390
+ E + L + G ++R +FLF +I++
Sbjct: 372 IKEGQIQKLSAKNGTPQDRHLFLFNSMILY 401
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 77.4 bits (189), Expect = 3e-14
Identities = 75/267 (28%), Positives = 126/267 (47%), Gaps = 29/267 (10%)
Query: 141 ETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLR 200
E +S P+ E K+ L E+ +TE+ Y D LG I + ++ + P+ +
Sbjct: 181 EPVSMPPKMTEYDKRCCC------LREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIE 234
Query: 201 GRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW--LAQLFIKHERRLHMYVVYC-QNKP 257
I+F NI+ + H +FL+E++ L P L Q+FIK++ R +Y YC Q +
Sbjct: 235 ----IIFINIEDLLRVHT-HFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVES 289
Query: 258 KSEHV-----VSEFGDSYFEELRQQLGH-RLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 311
S+H+ E EE Q+ + R L DLL+ P+QR++KY LLL++ +K+
Sbjct: 290 ASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQE 349
Query: 312 AGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPE 367
A M+ +L A++ M + + N D TL ++ F+ + + L Q P+
Sbjct: 350 A-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSI----ENLDQSLAHYGRPK 404
Query: 368 AGGLLSSRGRERRVFLFEQIIIFSEAL 394
G L ERR + + +AL
Sbjct: 405 IDGELKITSVERRSKMDRYAFLLDKAL 431
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 77.0 bits (188), Expect = 4e-14
Identities = 98/409 (23%), Positives = 170/409 (41%), Gaps = 55/409 (13%)
Query: 131 PGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM 190
P D P + ++ +E + K + + V++E++ TE+ Y+ L I EGY+
Sbjct: 257 PADDDAPLAGNSGAEDGGAEAQSSKDQMRTN--VINEILSTERDYIKHLRDICEGYVRQC 314
Query: 191 AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQL---FIKHERRLH 247
+ S + R +FGNI+ IY + + QR ++ L++L F++H+
Sbjct: 315 RKRADMFS-EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ 373
Query: 248 MYVVYCQNKPKSEHVVSEFGDS-----YFEELRQ-QLGHRLQLNDLLIKPVQRIMKYQLL 301
+Y YC N P + +S +FE R Q + L+ L+ PVQ+I KY L
Sbjct: 374 IYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQ 433
Query: 302 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND-----------MMTLGRLRGFEGK-- 348
L + LKY + D D+E A+ M V + N+ + +EG+
Sbjct: 434 LAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDL 493
Query: 349 LTAQGKLL-GQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIF--SEALGGGVRGGTQPG 405
L +L+ + VT+P+A + ++R FLF+ +I+ + L V
Sbjct: 494 LVRSSELIYSGELTRVTQPQA------KSQQRMFFLFDHQLIYCKKDLLRRDV------- 540
Query: 406 YVYKNSIKVSCL-------GLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWI 458
YK + + L G + +L RG G ++L P Q W+
Sbjct: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATG--DSHLLCTRKPEQKQRWL 598
Query: 459 KHVAQILESQRDFLNALQSPIEYQRRESQTNS-----LGRPRGPGVGSP 502
K A+ E + S E QR+++ N+ G+P+G +P
Sbjct: 599 KAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKGRRTAAP 647
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 75.9 bits (185), Expect = 1e-13
Identities = 61/214 (28%), Positives = 108/214 (50%), Gaps = 31/214 (14%)
Query: 142 TLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM-----AAQGVP 196
TLS + E E+K ++ EL+ETE+ YV L + + + + +++ P
Sbjct: 93 TLSGSGTQEPEKK---------IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFP 143
Query: 197 ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI-----KHERRLHMYVV 251
E + R++F NI IY++H +FL ELQR L D W A I K L MY
Sbjct: 144 EDVV---RVIFSNISSIYQFHSQFFLPELQRRLDD--WTANPRIGDVIQKLAPFLKMYSE 198
Query: 252 YCQNKPKSEHVVSEFGDS--YFEELRQQL-----GHRLQLNDLLIKPVQRIMKYQLLLKD 304
Y +N ++ +++ + D F+E+ ++ L L +++PVQRI +Y+LLLK+
Sbjct: 199 YVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKE 258
Query: 305 FLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMT 338
+++ D AD ++A++++ + N +T
Sbjct: 259 YIQKLPAQAPDQADAQKALDMIFSAAQHSNAAIT 292
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 74.7 bits (182), Expect = 2e-13
Identities = 97/405 (23%), Positives = 168/405 (41%), Gaps = 55/405 (13%)
Query: 131 PGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM 190
P D P + ++ +E + K + + V++E++ TE+ Y+ L I EGY+
Sbjct: 257 PADDDAPLAGNSGAEDGGAEAQSSKDQMRTN--VINEILSTERDYIKHLRDICEGYVRQC 314
Query: 191 AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQL---FIKHERRLH 247
+ S + R +FGNI+ IY + + QR ++ L++L F++H+
Sbjct: 315 RKRADMFS-EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ 373
Query: 248 MYVVYCQNKPKSEHVVSEFGDS-----YFEELRQ-QLGHRLQLNDLLIKPVQRIMKYQLL 301
+Y YC N P + +S +FE R Q + L+ L+ PVQ+I KY L
Sbjct: 374 IYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQ 433
Query: 302 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND-----------MMTLGRLRGFEGK-- 348
L + LKY + D D+E A+ M V + N+ + +EG+
Sbjct: 434 LAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDL 493
Query: 349 LTAQGKLL-GQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIF--SEALGGGVRGGTQPG 405
L +L+ + VT+P+A + ++R FLF+ +I+ + L V
Sbjct: 494 LVRSSELIYSGELTRVTQPQA------KSQQRMFFLFDHQLIYCKKDLLRRDV------- 540
Query: 406 YVYKNSIKVSCL-------GLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWI 458
YK + + L G + +L RG G ++L P Q W+
Sbjct: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATG--DSHLLCTRKPEQKQRWL 598
Query: 459 KHVAQILESQRDFLNALQSPIEYQRRESQTNS-----LGRPRGPG 498
K A+ E + S E QR+++ N+ G+P+ G
Sbjct: 599 KAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKAVG 643
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 73.9 bits (180), Expect = 4e-13
Identities = 91/411 (22%), Positives = 163/411 (39%), Gaps = 76/411 (18%)
Query: 45 SASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYE 104
S S GL P+ PSS + SP P SGL + D S + A
Sbjct: 387 SISFPEGLRTPASPSSANAFYSLSPSTLVP-SGLPEFKDSSSSLTDPQVSYVKSPAAERR 445
Query: 105 NWMLEPALATGEELPELTLL--TTLLEGPGDKTQPPEEETLS-----------QAPESEE 151
+ A+A G + P L L GPG T+ P+ S Q P
Sbjct: 446 SG----AVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVPLGPA 501
Query: 152 EQ-------------------------KKKALERSMYVLSELVETEKMYVDDLGQIVEGY 186
EQ K+ + + +++ E++ TE+ Y+ DL I +
Sbjct: 502 EQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWF 561
Query: 187 MATMAAQ-GVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLK------------DPD 233
+ + + +P +L ++F NI IYE+HR FL+E+++ L
Sbjct: 562 RSAVVKEDAMPATLM---TLLFSNIDPIYEFHRG-FLREVEQRLALWEGPSKAHTKGSHQ 617
Query: 234 WLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFG---------DSYFEELRQQLGHRLQL 284
+ + +++ R+L + Y Q + + V++E ++ ++E Q L L
Sbjct: 618 RIGDILLRNMRQLKEFTSYFQ---RHDEVLTELEKATKRCKKLEAVYKEFELQKVCYLPL 674
Query: 285 NDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMM----TLG 340
N L+KP+QR++ Y+LLL+ +Y+ D AD A++ + V ++ L
Sbjct: 675 NTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQ 734
Query: 341 RLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFS 391
+L + L L+ ++ E L ++R FLF +++++
Sbjct: 735 KLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLYT 785
>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 72.0 bits (175), Expect = 1e-12
Identities = 55/221 (24%), Positives = 108/221 (48%), Gaps = 14/221 (6%)
Query: 128 LEGPGDKTQPPEEETLSQAP--ESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEG 185
LE D+ + E++ P E +E + ++ ++ +EL++TEK YV L + +
Sbjct: 339 LEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQV 398
Query: 186 YMATMAAQGVPESLRGRDRI--VFGNIQQIYEWHRDYFLQELQRCLKDPDW---LAQLFI 240
+ A + + S D + +F NI IY +H+ + L EL++ +++ D + +
Sbjct: 399 FCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQ 458
Query: 241 KHERRLHMYVVYCQNKPKSEHVVS-------EFGDSYFEELRQQLGHRLQLNDLLIKPVQ 293
K L MY Y +N ++ +V+ +F E +++ L L +++PVQ
Sbjct: 459 KLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQ 518
Query: 294 RIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCN 334
RI +Y+LLLKD+L D+ D ++++E++ + N
Sbjct: 519 RIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSN 559
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,139,460
Number of Sequences: 37866
Number of extensions: 1388679
Number of successful extensions: 10612
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 166
Number of HSP's that attempted gapping in prelim test: 9585
Number of HSP's gapped (non-prelim): 1055
length of query: 580
length of database: 18,247,518
effective HSP length: 108
effective length of query: 472
effective length of database: 14,157,990
effective search space: 6682571280
effective search space used: 6682571280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.