BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapiens] (580 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 1180 0.0 gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 1108 0.0 gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 461 e-129 gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 430 e-120 gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 430 e-120 gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 231 1e-60 gi|148529025 pleckstrin homology domain containing, family G (wi... 197 2e-50 gi|163644325 MCF.2 cell line derived transforming sequence-like ... 192 7e-49 gi|163644323 MCF.2 cell line derived transforming sequence-like ... 192 7e-49 gi|153791628 MCF.2 cell line derived transforming sequence isofo... 184 3e-46 gi|153791325 MCF.2 cell line derived transforming sequence isofo... 184 3e-46 gi|193211603 pleckstrin homology domain containing, family G (wi... 175 9e-44 gi|193211598 pleckstrin homology domain containing, family G (wi... 175 9e-44 gi|193211596 pleckstrin homology domain containing, family G (wi... 175 9e-44 gi|193211594 pleckstrin homology domain containing, family G (wi... 175 9e-44 gi|55742734 pleckstrin homology domain containing, family G (wit... 175 9e-44 gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 156 4e-38 gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 126 5e-29 gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 126 5e-29 gi|71274148 pleckstrin homology domain containing, family G (wit... 113 5e-25 gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 113 5e-25 gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 104 2e-22 gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 84 4e-16 gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 84 4e-16 gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 77 3e-14 gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 77 4e-14 gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 76 1e-13 gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 75 2e-13 gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 74 4e-13 gi|24797153 faciogenital dysplasia protein [Homo sapiens] 72 1e-12 >gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapiens] Length = 580 Score = 1180 bits (3052), Expect = 0.0 Identities = 580/580 (100%), Positives = 580/580 (100%) Query: 1 MRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSS 60 MRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSS Sbjct: 1 MRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSS 60 Query: 61 GLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPE 120 GLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPE Sbjct: 61 GLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPE 120 Query: 121 LTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLG 180 LTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLG Sbjct: 121 LTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLG 180 Query: 181 QIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI 240 QIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI Sbjct: 181 QIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI 240 Query: 241 KHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQL 300 KHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQL Sbjct: 241 KHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQL 300 Query: 301 LLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDT 360 LLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDT Sbjct: 301 LLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDT 360 Query: 361 FWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLE 420 FWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLE Sbjct: 361 FWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLE 420 Query: 421 GNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIE 480 GNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIE Sbjct: 421 GNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIE 480 Query: 481 YQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLP 540 YQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLP Sbjct: 481 YQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLP 540 Query: 541 LDKQALGDIPQAPHDSPPVSPTPKTPPCQARLAKLDEDEL 580 LDKQALGDIPQAPHDSPPVSPTPKTPPCQARLAKLDEDEL Sbjct: 541 LDKQALGDIPQAPHDSPPVSPTPKTPPCQARLAKLDEDEL 580 >gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapiens] Length = 619 Score = 1108 bits (2866), Expect = 0.0 Identities = 548/548 (100%), Positives = 548/548 (100%) Query: 33 ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE 92 ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE Sbjct: 72 ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE 131 Query: 93 TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE 152 TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE Sbjct: 132 TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE 191 Query: 153 QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ 212 QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ Sbjct: 192 QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ 251 Query: 213 IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE 272 IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE Sbjct: 252 IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE 311 Query: 273 ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR 332 ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR Sbjct: 312 ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR 371 Query: 333 CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE 392 CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE Sbjct: 372 CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE 431 Query: 393 ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA 452 ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA Sbjct: 432 ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA 491 Query: 453 ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ 512 ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ Sbjct: 492 ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ 551 Query: 513 GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL 572 GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL Sbjct: 552 GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL 611 Query: 573 AKLDEDEL 580 AKLDEDEL Sbjct: 612 AKLDEDEL 619 >gi|45439359 triple functional domain (PTPRF interacting) [Homo sapiens] Length = 3097 Score = 461 bits (1185), Expect = e-129 Identities = 249/456 (54%), Positives = 322/456 (70%), Gaps = 18/456 (3%) Query: 125 TTLLEGPGDKTQP---PEEETL--SQAPESE-EEQKKKALERSMYVLSELVETEKMYVDD 178 ++LL GD + P P + +L S +P E EE+K +L+R YVL ELVETE+ YV D Sbjct: 1928 SSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRD 1987 Query: 179 LGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQL 238 LG +VEGYMA M GVP+ ++G+D+IVFGNI QIY+WHRD+FL EL++CL+DP+ L L Sbjct: 1988 LGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSL 2047 Query: 239 FIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKY 298 F+KHERRLHMY+ YCQNKPKSEH+VSE+ D++FE+L+Q+LGHRLQL DLLIKPVQRIMKY Sbjct: 2048 FVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKY 2107 Query: 299 QLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQ 358 QLLLKDFLKY +A +DT++LE+AVEVMC VP+RCNDMM +GRL+GF+GK+ AQGKLL Q Sbjct: 2108 QLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQ 2167 Query: 359 DTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLG 418 DTF VT+ +AG L R RERR+FLFEQI+IFSE L +G + PG+++KNSIKVSCL Sbjct: 2168 DTFLVTDQDAG--LLPRCRERRIFLFEQIVIFSEPL-DKKKGFSMPGFLFKNSIKVSCLC 2224 Query: 419 LEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSP 478 LE N++ DPC+FALTSR + ++ ++L ++ P++ Q WI + QILE+QR+FLNAL SP Sbjct: 2225 LEENVENDPCKFALTSRTGD-VVETFILHSSSPSVRQTWIHEINQILENQRNFLNALTSP 2283 Query: 479 IEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHT--PIN-GSLPSLLLSPKGEVA 535 IEYQR S G G G G G G + GS H+ P + G PS S + Sbjct: 2284 IEYQRNHSGGGGGGGSGGSG-GGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSRIP 2342 Query: 536 RALL----PLDKQALGDIPQAPHDSPPVSPTPKTPP 567 + + L A +A S +P P PP Sbjct: 2343 QPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPP 2378 Score = 236 bits (601), Expect = 6e-62 Identities = 131/370 (35%), Positives = 212/370 (57%), Gaps = 12/370 (3%) Query: 137 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQG 194 P E L A E+K+K+ R ++++EL++TEK YV DL + ++ Y+ T + Sbjct: 1269 PGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEE 1328 Query: 195 VPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQ 254 +P + ++ I+FGN+Q+IYE+H + FL+EL++ + P+ + F+ + MYV YC+ Sbjct: 1329 IPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCK 1388 Query: 255 NKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGM 314 NKP S ++ E SYF+E++Q+ G ++ LIKPVQRI KYQLLLK+ L Sbjct: 1389 NKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG-- 1446 Query: 315 DTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSS 374 +++ +EVM VPKR ND M L L GF+ + +QG+L+ Q++F V +P+ L Sbjct: 1447 -KGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKT---LIR 1502 Query: 375 RGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTS 434 +GRER +FLFE ++FS+ + + Y+YK+ + S LG+ +++GDPC+FAL Sbjct: 1503 KGRERHLFLFEMSLVFSKEVKD---SSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWV 1559 Query: 435 RGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEYQRRESQTNSLGR 493 + VL+A+ Q WIKH+ ++++ + L AL+ PI + T GR Sbjct: 1560 GRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGR 1619 Query: 494 PRGPGVGSPG 503 G + S G Sbjct: 1620 RDGEDLDSQG 1629 >gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] Length = 2986 Score = 430 bits (1106), Expect = e-120 Identities = 212/339 (62%), Positives = 274/339 (80%), Gaps = 9/339 (2%) Query: 150 EEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGN 209 EEEQK KAL M+VL+ELV+TEK YV DLG +VEG+M + +GVPE +RG+D+IVFGN Sbjct: 1919 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGN 1978 Query: 210 IQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS 269 I QIY+WH+D+FL EL++C+++ D LAQLFIKHER+LH+YV YCQNKP+SE++V+E+ D+ Sbjct: 1979 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 2037 Query: 270 YFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFV 329 YFEE++Q++ RL L+D LIKP+QRI KYQLLLKDFL+Y +AG++ +D+E+AVE+MC V Sbjct: 2038 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097 Query: 330 PKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIII 389 PKRCNDMM LGRL+GFEG LTAQGKLL QDTF+V E +AG + SR +ERRVFLFEQI+I Sbjct: 2098 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAG--MQSRTKERRVFLFEQIVI 2155 Query: 390 FSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAA 449 FSE L +G PGY++K SIK++ L LE N+ DPC+FAL +R +R VLQAA Sbjct: 2156 FSELLR---KGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETS---ERVVLQAA 2209 Query: 450 DPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQT 488 + I QAW++ + Q+LE+QRDFLNALQSPIEYQR+E T Sbjct: 2210 NADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERST 2248 Score = 231 bits (589), Expect = 1e-60 Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%) Query: 140 EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 197 E L A E+K+K+ + ++++EL++TEK YV DL + +E Y+ T + +P Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320 Query: 198 SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 257 + ++ I+FGNIQ+IY++H + FL+EL++ + P+ + F+ + MYV YC+NKP Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380 Query: 258 KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 317 S ++ E ++F+E++Q+ G ++ LIKPVQRI KYQLLLK+ L Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437 Query: 318 DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 377 +L+ +EVM VPK+ ND M + L GF+ L QG+L+ QD F V +P++ L +GR Sbjct: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494 Query: 378 ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 437 ER +FLFE ++FS+ + G T+ YVYKN + S LG+ +++GDPC+FAL S Sbjct: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551 Query: 438 EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 490 + VL+A++ Q WIK++ ++++ + L AL+ P++ QR S+ + Sbjct: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611 Query: 491 LG--RPRGPGVGSPGRIRLGDQAQGST 515 + +G G P I + + +T Sbjct: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638 Score = 30.0 bits (66), Expect = 6.1 Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 6/58 (10%) Query: 26 CFARGGRESYSIAGSE-GSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWL 82 CF +++YS + SE G S S A+ A PS L+S SPGP + L++WL Sbjct: 1719 CFFPLVKDAYSHSSSENGGKSESVANLQAQPS-----LNSIHSSPGPKRSTNTLKKWL 1771 >gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] Length = 1289 Score = 430 bits (1106), Expect = e-120 Identities = 212/339 (62%), Positives = 274/339 (80%), Gaps = 9/339 (2%) Query: 150 EEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGN 209 EEEQK KAL M+VL+ELV+TEK YV DLG +VEG+M + +GVPE +RG+D+IVFGN Sbjct: 222 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGN 281 Query: 210 IQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS 269 I QIY+WH+D+FL EL++C+++ D LAQLFIKHER+LH+YV YCQNKP+SE++V+E+ D+ Sbjct: 282 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 340 Query: 270 YFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFV 329 YFEE++Q++ RL L+D LIKP+QRI KYQLLLKDFL+Y +AG++ +D+E+AVE+MC V Sbjct: 341 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 400 Query: 330 PKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIII 389 PKRCNDMM LGRL+GFEG LTAQGKLL QDTF+V E +AG + SR +ERRVFLFEQI+I Sbjct: 401 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAG--MQSRTKERRVFLFEQIVI 458 Query: 390 FSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAA 449 FSE L +G PGY++K SIK++ L LE N+ DPC+FAL +R +R VLQAA Sbjct: 459 FSELLR---KGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETS---ERVVLQAA 512 Query: 450 DPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQT 488 + I QAW++ + Q+LE+QRDFLNALQSPIEYQR+E T Sbjct: 513 NADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERST 551 Score = 38.5 bits (88), Expect = 0.017 Identities = 27/65 (41%), Positives = 36/65 (55%), Gaps = 8/65 (12%) Query: 19 VLAKCGCCFARGGRESYSIAGSE-GSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSG 77 + AKC CCF R++YS + SE G S S A+ A PS L+S SPGP + Sbjct: 17 LFAKCCCCFPC--RDAYSHSSSENGGKSESVANLQAQPS-----LNSIHSSPGPKRSTNT 69 Query: 78 LRRWL 82 L++WL Sbjct: 70 LKKWL 74 >gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] Length = 1663 Score = 231 bits (589), Expect = 1e-60 Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%) Query: 140 EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 197 E L A E+K+K+ + ++++EL++TEK YV DL + +E Y+ T + +P Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320 Query: 198 SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 257 + ++ I+FGNIQ+IY++H + FL+EL++ + P+ + F+ + MYV YC+NKP Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380 Query: 258 KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 317 S ++ E ++F+E++Q+ G ++ LIKPVQRI KYQLLLK+ L Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437 Query: 318 DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 377 +L+ +EVM VPK+ ND M + L GF+ L QG+L+ QD F V +P++ L +GR Sbjct: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494 Query: 378 ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 437 ER +FLFE ++FS+ + G T+ YVYKN + S LG+ +++GDPC+FAL S Sbjct: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551 Query: 438 EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 490 + VL+A++ Q WIK++ ++++ + L AL+ P++ QR S+ + Sbjct: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611 Query: 491 LG--RPRGPGVGSPGRIRLGDQAQGST 515 + +G G P I + + +T Sbjct: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638 >gi|148529025 pleckstrin homology domain containing, family G (with RhoGef domain) member 4B [Homo sapiens] Length = 1271 Score = 197 bits (501), Expect = 2e-50 Identities = 115/375 (30%), Positives = 204/375 (54%), Gaps = 21/375 (5%) Query: 147 PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIV 206 P E+ +++ R ++++E++ TE+ Y+ LG +++ Y M +P+ LRG+ ++ Sbjct: 792 PAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHHVI 851 Query: 207 FGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEF 266 FGN+++++++H+ +FL+EL+RC P + + F++HE + MYV+Y +NKP+S+ ++S Sbjct: 852 FGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSH 911 Query: 267 GDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYN---RAGMDTADLEQAV 323 G+++F++ +++LG ++ L L++PVQR+ KY LLL+D LK + G + +L A Sbjct: 912 GNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAE 971 Query: 324 EVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 383 V+CF + ND++ + +RG + L QG+L +D F V + R VFL Sbjct: 972 VVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV-------CCGRKKYLRHVFL 1024 Query: 384 FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQR 443 FE +I+FS+ G+ Y+YK S K + +G+ N+ RF + R Sbjct: 1025 FEDLILFSKT---QKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDT 1081 Query: 444 YVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPG 503 Y+LQA+ + AW + +IL Q AL+S + R + S+G P + Sbjct: 1082 YILQASSAEVKSAWTDVIGRILWRQ-----ALKS---RELRIQEMASMGIGNQPFMDVKP 1133 Query: 504 RIRLGDQAQGSTHTP 518 R R D A S P Sbjct: 1134 RDRTPDCAVISDRAP 1148 >gi|163644325 MCF.2 cell line derived transforming sequence-like isoform a [Homo sapiens] Length = 1182 Score = 192 bits (488), Expect = 7e-49 Identities = 128/390 (32%), Positives = 211/390 (54%), Gaps = 22/390 (5%) Query: 127 LLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGY 186 L GP + + E+ + EE++ A+ R +V+SEL++TE+ YV++L ++EGY Sbjct: 626 LRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR-HVMSELLDTERAYVEELLCVLEGY 684 Query: 187 MATM----AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKH 242 A M A + L + ++FGN+++IY +H FL+EL+ P+ + + F++ Sbjct: 685 AAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLER 744 Query: 243 ERRLHMYVVYCQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 301 +Y YCQNKP+SE + + D +F+E +++L H+L L+ L+KPVQRI KYQLL Sbjct: 745 MEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLL 804 Query: 302 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF 361 LK+ LK Y+R DL++A+ + + K ND M L + G++G L GKLL Q +F Sbjct: 805 LKEMLK-YSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSF 863 Query: 362 WVTEPEAGG------LLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQ-PGYVYKNSIKV 414 V G L + +R +FL E+ ++F + G + P Y YK S+ + Sbjct: 864 SVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNM 923 Query: 415 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 474 + +G+ N++GD +F + E + Y++QA P I AW+ + ++L SQ L A Sbjct: 924 AAVGITENVKGDAKKFEIWYNARE---EVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQA 977 Query: 475 LQSPIEYQRRESQTNSLGRPRGPGVGSPGR 504 + +++ E Q+ SL P P SP R Sbjct: 978 CREASQHRALE-QSQSLPLP-APTSTSPSR 1005 >gi|163644323 MCF.2 cell line derived transforming sequence-like isoform b [Homo sapiens] Length = 1129 Score = 192 bits (488), Expect = 7e-49 Identities = 128/390 (32%), Positives = 211/390 (54%), Gaps = 22/390 (5%) Query: 127 LLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGY 186 L GP + + E+ + EE++ A+ R +V+SEL++TE+ YV++L ++EGY Sbjct: 573 LRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR-HVMSELLDTERAYVEELLCVLEGY 631 Query: 187 MATM----AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKH 242 A M A + L + ++FGN+++IY +H FL+EL+ P+ + + F++ Sbjct: 632 AAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLER 691 Query: 243 ERRLHMYVVYCQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 301 +Y YCQNKP+SE + + D +F+E +++L H+L L+ L+KPVQRI KYQLL Sbjct: 692 MEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLL 751 Query: 302 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF 361 LK+ LK Y+R DL++A+ + + K ND M L + G++G L GKLL Q +F Sbjct: 752 LKEMLK-YSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSF 810 Query: 362 WVTEPEAGG------LLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQ-PGYVYKNSIKV 414 V G L + +R +FL E+ ++F + G + P Y YK S+ + Sbjct: 811 SVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNM 870 Query: 415 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 474 + +G+ N++GD +F + E + Y++QA P I AW+ + ++L SQ L A Sbjct: 871 AAVGITENVKGDAKKFEIWYNARE---EVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQA 924 Query: 475 LQSPIEYQRRESQTNSLGRPRGPGVGSPGR 504 + +++ E Q+ SL P P SP R Sbjct: 925 CREASQHRALE-QSQSLPLP-APTSTSPSR 952 >gi|153791628 MCF.2 cell line derived transforming sequence isoform a [Homo sapiens] Length = 985 Score = 184 bits (466), Expect = 3e-46 Identities = 112/348 (32%), Positives = 190/348 (54%), Gaps = 16/348 (4%) Query: 137 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGV- 195 P +E S P S + +VL+EL++TE++YV +L ++ GY A M + Sbjct: 532 PDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMF 591 Query: 196 ---PESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVY 252 P LR + I+FGN+ +IYE+H D FL L+ C P+ + F++ + MY Y Sbjct: 592 DLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKY 651 Query: 253 CQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 311 CQNKP+SE + ++ + ++F+E +++L HRL+L+ L+KPVQRI KYQLLLK+ LK Y++ Sbjct: 652 CQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-YSK 710 Query: 312 AGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF--WVTEPEAG 369 +A L++A++ M + K ND M + G+ G L GK++ Q F W+ + Sbjct: 711 DCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGA 770 Query: 370 GLLSSRGR----ERRVFLFEQIIIF-SEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQ 424 + R +R +FL+E+ I+F + G P Y +K+ K+ +G+ ++ Sbjct: 771 TKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVK 830 Query: 425 GDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL 472 GD +F + E + Y++QA++ + W+K + IL Q++ L Sbjct: 831 GDNRKFEIWYGEKE---EVYIVQASNVDVKMTWLKEIRNILLKQQELL 875 >gi|153791325 MCF.2 cell line derived transforming sequence isoform b [Homo sapiens] Length = 925 Score = 184 bits (466), Expect = 3e-46 Identities = 112/348 (32%), Positives = 190/348 (54%), Gaps = 16/348 (4%) Query: 137 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGV- 195 P +E S P S + +VL+EL++TE++YV +L ++ GY A M + Sbjct: 472 PDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMF 531 Query: 196 ---PESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVY 252 P LR + I+FGN+ +IYE+H D FL L+ C P+ + F++ + MY Y Sbjct: 532 DLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKY 591 Query: 253 CQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 311 CQNKP+SE + ++ + ++F+E +++L HRL+L+ L+KPVQRI KYQLLLK+ LK Y++ Sbjct: 592 CQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-YSK 650 Query: 312 AGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF--WVTEPEAG 369 +A L++A++ M + K ND M + G+ G L GK++ Q F W+ + Sbjct: 651 DCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGA 710 Query: 370 GLLSSRGR----ERRVFLFEQIIIF-SEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQ 424 + R +R +FL+E+ I+F + G P Y +K+ K+ +G+ ++ Sbjct: 711 TKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVK 770 Query: 425 GDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL 472 GD +F + E + Y++QA++ + W+K + IL Q++ L Sbjct: 771 GDNRKFEIWYGEKE---EVYIVQASNVDVKMTWLKEIRNILLKQQELL 815 >gi|193211603 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 isoform 2 [Homo sapiens] Length = 1110 Score = 175 bits (444), Expect = 9e-44 Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%) Query: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215 ++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ + Sbjct: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 706 Query: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275 +H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ + Sbjct: 707 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 766 Query: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335 Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND Sbjct: 767 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 826 Query: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395 ++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+ Sbjct: 827 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 879 Query: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455 G T + YK S K++ LGL RF + R + +VLQA+ AI Q Sbjct: 880 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 935 Query: 456 AWIKHVAQILESQ 468 AW ++ +L Q Sbjct: 936 AWTADISHLLWRQ 948 >gi|193211598 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 isoform 1 [Homo sapiens] Length = 1191 Score = 175 bits (444), Expect = 9e-44 Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%) Query: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215 ++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ + Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787 Query: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275 +H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ + Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847 Query: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335 Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907 Query: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395 ++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+ Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960 Query: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455 G T + YK S K++ LGL RF + R + +VLQA+ AI Q Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016 Query: 456 AWIKHVAQILESQ 468 AW ++ +L Q Sbjct: 1017 AWTADISHLLWRQ 1029 >gi|193211596 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 isoform 1 [Homo sapiens] Length = 1191 Score = 175 bits (444), Expect = 9e-44 Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%) Query: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215 ++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ + Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787 Query: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275 +H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ + Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847 Query: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335 Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907 Query: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395 ++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+ Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960 Query: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455 G T + YK S K++ LGL RF + R + +VLQA+ AI Q Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016 Query: 456 AWIKHVAQILESQ 468 AW ++ +L Q Sbjct: 1017 AWTADISHLLWRQ 1029 >gi|193211594 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 isoform 1 [Homo sapiens] Length = 1191 Score = 175 bits (444), Expect = 9e-44 Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%) Query: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215 ++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ + Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787 Query: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275 +H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ + Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847 Query: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335 Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907 Query: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395 ++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+ Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960 Query: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455 G T + YK S K++ LGL RF + R + +VLQA+ AI Q Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016 Query: 456 AWIKHVAQILESQ 468 AW ++ +L Q Sbjct: 1017 AWTADISHLLWRQ 1029 >gi|55742734 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 isoform 1 [Homo sapiens] Length = 1191 Score = 175 bits (444), Expect = 9e-44 Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%) Query: 156 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 215 ++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ + Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787 Query: 216 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 275 +H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ + Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847 Query: 276 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 335 Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907 Query: 336 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 395 ++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+ Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960 Query: 396 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 455 G T + YK S K++ LGL RF + R + +VLQA+ AI Q Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016 Query: 456 AWIKHVAQILESQ 468 AW ++ +L Q Sbjct: 1017 AWTADISHLLWRQ 1029 >gi|31742505 Rho family guanine-nucleotide exchange factor [Homo sapiens] Length = 1114 Score = 156 bits (395), Expect = 4e-38 Identities = 108/407 (26%), Positives = 198/407 (48%), Gaps = 38/407 (9%) Query: 147 PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM----AAQGVPESLRGR 202 PE E++ + L ++ +L+ETE++Y+ ++ I++GY+ M +P+ L+ Sbjct: 606 PELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNN 665 Query: 203 DRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHV 262 +FGNI+++YE+H FL+EL++C ++P+ LA F+K + L +Y Y +N P++ + Sbjct: 666 KDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAI 725 Query: 263 VSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMD------ 315 E D +YF ++QL H L L L P QR++KYQ+LLK L + + M+ Sbjct: 726 WQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGEL 785 Query: 316 ----------------TADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLL--G 357 + +L+QA+ V+ + K C + L + + GKLL G Sbjct: 786 GGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHG 845 Query: 358 QDTFWVTEPE---AGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKV 414 + W + L+ + +R+++LFE+ I+F + G P Y +K ++K+ Sbjct: 846 PFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKL 905 Query: 415 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 474 L + +G +F + SR G+++Y+LQAA I W ++++L Q++ + Sbjct: 906 MTLSIRQLGRGSHRKFEIASR---NGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKD 962 Query: 475 LQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPING 521 +P Q S + G GP + + R + S+ I G Sbjct: 963 QGNP---QFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKG 1006 >gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF isoform a [Homo sapiens] Length = 6620 Score = 126 bits (317), Expect = 5e-29 Identities = 99/338 (29%), Positives = 168/338 (49%), Gaps = 27/338 (7%) Query: 144 SQAPE------SEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMA-AQGVP 196 ++APE SE+E K R V+ EL+ +E+ +V++L + ++ + VP Sbjct: 5675 AEAPEFPGEAVSEDEYKA----RLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVP 5730 Query: 197 ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNK 256 ++ G+ ++F N++ I +H FLQELQ+C D D +A FIK++ Y+ + + Sbjct: 5731 IAVAGQKAVIFRNVRDIGRFHSS-FLQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGR 5788 Query: 257 PKSEHVV-----SEFGDSYFEELRQQLGHRLQ-----LNDLLIKPVQRIMKYQLLLKDFL 306 ++E VV EF Y EE G Q L L +PV+R+ +YQ LLK+ + Sbjct: 5789 VQAESVVVSTAIQEFYKKYAEEALLA-GDPSQPPPPPLQHYLEQPVERVQRYQALLKELI 5847 Query: 307 KYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEP 366 + R + A LEQA V+ +P+R + + + + + G L A G+ + Q F V E Sbjct: 5848 RNKARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEG 5907 Query: 367 EAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGD 426 G + +G R VFLF ++ + R T YV++N +K+S + L ++GD Sbjct: 5908 APGARMPWKGHNRHVFLFRNHLVICKPRRDS-RTDT-VSYVFRNMMKLSSIDLNDQVEGD 5965 Query: 427 PCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQI 464 F + E +++Y+LQA I +W+K + I Sbjct: 5966 DRAFEVWQE-REDSVRKYLLQARTAIIKSSWVKEICGI 6002 >gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF isoform b [Homo sapiens] Length = 7968 Score = 126 bits (317), Expect = 5e-29 Identities = 99/338 (29%), Positives = 168/338 (49%), Gaps = 27/338 (7%) Query: 144 SQAPE------SEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMA-AQGVP 196 ++APE SE+E K R V+ EL+ +E+ +V++L + ++ + VP Sbjct: 5675 AEAPEFPGEAVSEDEYKA----RLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVP 5730 Query: 197 ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNK 256 ++ G+ ++F N++ I +H FLQELQ+C D D +A FIK++ Y+ + + Sbjct: 5731 IAVAGQKAVIFRNVRDIGRFHSS-FLQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGR 5788 Query: 257 PKSEHVV-----SEFGDSYFEELRQQLGHRLQ-----LNDLLIKPVQRIMKYQLLLKDFL 306 ++E VV EF Y EE G Q L L +PV+R+ +YQ LLK+ + Sbjct: 5789 VQAESVVVSTAIQEFYKKYAEEALLA-GDPSQPPPPPLQHYLEQPVERVQRYQALLKELI 5847 Query: 307 KYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEP 366 + R + A LEQA V+ +P+R + + + + + G L A G+ + Q F V E Sbjct: 5848 RNKARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEG 5907 Query: 367 EAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGD 426 G + +G R VFLF ++ + R T YV++N +K+S + L ++GD Sbjct: 5908 APGARMPWKGHNRHVFLFRNHLVICKPRRDS-RTDT-VSYVFRNMMKLSSIDLNDQVEGD 5965 Query: 427 PCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQI 464 F + E +++Y+LQA I +W+K + I Sbjct: 5966 DRAFEVWQE-REDSVRKYLLQARTAIIKSSWVKEICGI 6002 >gi|71274148 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 [Homo sapiens] Length = 1385 Score = 113 bits (282), Expect = 5e-25 Identities = 91/321 (28%), Positives = 155/321 (48%), Gaps = 41/321 (12%) Query: 164 VLSELVETEKMYVDDLGQIVEGYMATMAAQG-VPESLRGRDRIVFGNIQQIYEWHRDYFL 222 V+ E++ETE+ YV DL IVE Y+ + Q +P R + FGNIQ IY ++ + L Sbjct: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSAL-FGNIQDIYHFNSE-LL 174 Query: 223 QELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSE-----FGDSYFEELRQQ 277 Q+L+ C DP +A+ F+ H+Y YC N P+S V++E +F E ++ Sbjct: 175 QDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQET 234 Query: 278 LGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMM 337 L H L L L+KPVQRI+KY LLL + + ++ + A++ M V NDM Sbjct: 235 LKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMK 294 Query: 338 -----------TLGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFE 385 L ++G LT+ G+L+ + TF + + ER +FLF+ Sbjct: 295 RKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAK---------NERTLFLFD 345 Query: 386 QIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTS-RGPEGGIQRY 444 ++++ ++ R T + YK I L L + +P F++ + P+ ++ Sbjct: 346 KLLLITKK-----RDDT---FTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPK---LQH 394 Query: 445 VLQAADPAISQAWIKHVAQIL 465 +QA + W+ H+ +++ Sbjct: 395 TVQAKSQQDKRLWVLHLKRLI 415 >gi|50843837 hypothetical protein LOC55701 [Homo sapiens] Length = 1519 Score = 113 bits (282), Expect = 5e-25 Identities = 155/600 (25%), Positives = 240/600 (40%), Gaps = 97/600 (16%) Query: 8 GRCA--CPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSSGLSSG 65 GRC C + R++ G Y ++G+ S A G P PS LSS Sbjct: 939 GRCQARCQELERRIQQHVG---EEASPRGYRRRRADGASSGGAQWG---PRSPSPSLSSL 992 Query: 66 --PCSPGP-PGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELT 122 P SPGP P P HC D + GP L P E P Sbjct: 993 LLPSSPGPRPAP-----------SHCSLAPCGEDYEEEGPE----LAPE---AEGRPPRA 1034 Query: 123 LLTTLLEGPG----DKTQPPEEETL---SQAPE------SEEEQKKKALERSMYVLSELV 169 +L LE D+T P E L ++ P+ + ++K+++ ++SEL+ Sbjct: 1035 VLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELI 1094 Query: 170 ETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCL 229 E+ YV L + V + PE LRG +++ +HR +FL+ELQ C Sbjct: 1095 ACEQDYVATLSEPVP----PPGPELTPE-LRGTWAAALSARERLRSFHRTHFLRELQGCA 1149 Query: 230 KDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLI 289 P + F++H + +Y Y +++ K E+ ++ S + + G L L Sbjct: 1150 THPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAAL--SPLSKGSMEAGP--YLPRALQ 1205 Query: 290 KPVQRIMKYQLLLKDFLKYYNRAGMDTAD----LEQAVEVMCFVPKRCNDMMTLGRLRGF 345 +P++++ +Y LL++ L+ AG + + L AV+++ R D++ + +RG Sbjct: 1206 QPLEQLTRYGRLLEELLR---EAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGC 1262 Query: 346 EGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPG 405 E L QG+LL +D F V + + R VFLFE +++FS+ G GG++ Sbjct: 1263 EIDLKEQGQLLHRDPFTV-------ICGRKKCLRHVFLFEHLLLFSKL--KGPEGGSEM- 1312 Query: 406 YVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQIL 465 +VYK + K + +GL N+ F L R + Y LQA P I W +AQ+L Sbjct: 1313 FVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAR-EAYTLQATSPEIKLKWTSSIAQLL 1371 Query: 466 ESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGV---------------GSPGRIRLGDQ 510 Q L R Q S+G P + G R R Sbjct: 1372 WRQAAHNKEL--------RVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVA 1423 Query: 511 AQGSTHTPINGSLPSL---LLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPP 567 H SLP L S V LD + + P+ S VSP P+ P Sbjct: 1424 VSSFEHA--GPSLPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSP 1481 >gi|164565408 common-site lymphoma/leukemia guanine nucleotide exchange factor [Homo sapiens] Length = 1386 Score = 104 bits (260), Expect = 2e-22 Identities = 114/376 (30%), Positives = 174/376 (46%), Gaps = 53/376 (14%) Query: 164 VLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQ 223 V E+VETE+ YV DL IVE Y+ + GV + +F NI+ IYE+ + L+ Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSE-LLE 164 Query: 224 ELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS-----YFEELRQQL 278 +L+ +A+ F++ +Y +YC N P S ++ E S + +E + QL Sbjct: 165 DLENS-SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQL 223 Query: 279 GHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTAD---LEQAVEVMCFVPKRCND 335 H L L L+KPVQRI+KY LLL++ K++ G T +E+A+ M V ND Sbjct: 224 RHSLPLQSFLLKPVQRILKYHLLLQELGKHW-AEGPGTGGREMVEEAIVSMTAVAWYIND 282 Query: 336 MM-----------TLGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 383 M RL G+ G +L+A G+L+ + F GG RG ER +FL Sbjct: 283 MKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF---RGGGGGGPRLRGGERLLFL 339 Query: 384 FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRG-PEGGIQ 442 F ++++ ++ R G + Y YK I L + + + DP F ++ P+ Sbjct: 340 FSRMLLVAK------RRGLE--YTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPK---H 387 Query: 443 RYVLQAADPAISQAWI---------KHVAQILESQRDFL--NALQ-SPIEYQRRESQTNS 490 R++LQA + + WI H A I + L N+L +P E T Sbjct: 388 RHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPP 447 Query: 491 LG--RPRGPGVGSPGR 504 LG RPR +PGR Sbjct: 448 LGSPRPRDARSFTPGR 463 >gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] Length = 725 Score = 84.0 bits (206), Expect = 4e-16 Identities = 97/390 (24%), Positives = 169/390 (43%), Gaps = 51/390 (13%) Query: 38 AGSEGSISASAASGLAAPSGPSSGLSSGPCSP--GPPGPVSGLRRWLDHSKHCLSVETEA 95 + S G + A A P S ++G SP GP G +SG + + S Sbjct: 26 SSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPNRDSGIDS----P 81 Query: 96 DSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQP---PEEET---LSQAPES 149 S AG EN+ E L G P T+L E D P P+EE + + P+S Sbjct: 82 SSSVAG--ENFPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQEEADSDVGEEPDS 136 Query: 150 EEEQKK----------KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVP-ES 198 E +K ++ +++ EL+ TE+ YV L + + + + G+P E Sbjct: 137 ENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEV 196 Query: 199 LRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW-----LAQLFIKHERRLHMYVVYC 253 + G +F NI I+ +H + L EL+ + + +W L + K L MY Y Sbjct: 197 IMG----IFSNISSIHRFHGQFLLPELKTRITE-EWDTNPRLGDILQKLAPFLKMYGEYV 251 Query: 254 QNKPKSEHVVSE-------FGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFL 306 +N ++ +VS F D +Q++ L L +++PVQR+ +Y+LLLKD+L Sbjct: 252 KNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYL 311 Query: 307 KYYNRAGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLTAQGKLLGQDTFW 362 K + D D E+++E++ N + + +L +L + ++ Sbjct: 312 KRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANEL 371 Query: 363 VTEPEAGGLLSSRG--RERRVFLFEQIIIF 390 + E + L + G ++R +FLF +I++ Sbjct: 372 IKEGQIQKLSAKNGTPQDRHLFLFNSMILY 401 >gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] Length = 725 Score = 84.0 bits (206), Expect = 4e-16 Identities = 97/390 (24%), Positives = 169/390 (43%), Gaps = 51/390 (13%) Query: 38 AGSEGSISASAASGLAAPSGPSSGLSSGPCSP--GPPGPVSGLRRWLDHSKHCLSVETEA 95 + S G + A A P S ++G SP GP G +SG + + S Sbjct: 26 SSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPNRDSGIDS----P 81 Query: 96 DSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQP---PEEET---LSQAPES 149 S AG EN+ E L G P T+L E D P P+EE + + P+S Sbjct: 82 SSSVAG--ENFPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQEEADSDVGEEPDS 136 Query: 150 EEEQKK----------KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVP-ES 198 E +K ++ +++ EL+ TE+ YV L + + + + G+P E Sbjct: 137 ENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEV 196 Query: 199 LRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW-----LAQLFIKHERRLHMYVVYC 253 + G +F NI I+ +H + L EL+ + + +W L + K L MY Y Sbjct: 197 IMG----IFSNISSIHRFHGQFLLPELKTRITE-EWDTNPRLGDILQKLAPFLKMYGEYV 251 Query: 254 QNKPKSEHVVSE-------FGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFL 306 +N ++ +VS F D +Q++ L L +++PVQR+ +Y+LLLKD+L Sbjct: 252 KNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYL 311 Query: 307 KYYNRAGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLTAQGKLLGQDTFW 362 K + D D E+++E++ N + + +L +L + ++ Sbjct: 312 KRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANEL 371 Query: 363 VTEPEAGGLLSSRG--RERRVFLFEQIIIF 390 + E + L + G ++R +FLF +I++ Sbjct: 372 IKEGQIQKLSAKNGTPQDRHLFLFNSMILY 401 >gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] Length = 845 Score = 77.4 bits (189), Expect = 3e-14 Identities = 75/267 (28%), Positives = 126/267 (47%), Gaps = 29/267 (10%) Query: 141 ETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLR 200 E +S P+ E K+ L E+ +TE+ Y D LG I + ++ + P+ + Sbjct: 181 EPVSMPPKMTEYDKRCCC------LREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIE 234 Query: 201 GRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW--LAQLFIKHERRLHMYVVYC-QNKP 257 I+F NI+ + H +FL+E++ L P L Q+FIK++ R +Y YC Q + Sbjct: 235 ----IIFINIEDLLRVHT-HFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVES 289 Query: 258 KSEHV-----VSEFGDSYFEELRQQLGH-RLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 311 S+H+ E EE Q+ + R L DLL+ P+QR++KY LLL++ +K+ Sbjct: 290 ASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQE 349 Query: 312 AGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPE 367 A M+ +L A++ M + + N D TL ++ F+ + + L Q P+ Sbjct: 350 A-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSI----ENLDQSLAHYGRPK 404 Query: 368 AGGLLSSRGRERRVFLFEQIIIFSEAL 394 G L ERR + + +AL Sbjct: 405 IDGELKITSVERRSKMDRYAFLLDKAL 431 >gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [Homo sapiens] Length = 670 Score = 77.0 bits (188), Expect = 4e-14 Identities = 98/409 (23%), Positives = 170/409 (41%), Gaps = 55/409 (13%) Query: 131 PGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM 190 P D P + ++ +E + K + + V++E++ TE+ Y+ L I EGY+ Sbjct: 257 PADDDAPLAGNSGAEDGGAEAQSSKDQMRTN--VINEILSTERDYIKHLRDICEGYVRQC 314 Query: 191 AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQL---FIKHERRLH 247 + S + R +FGNI+ IY + + QR ++ L++L F++H+ Sbjct: 315 RKRADMFS-EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ 373 Query: 248 MYVVYCQNKPKSEHVVSEFGDS-----YFEELRQ-QLGHRLQLNDLLIKPVQRIMKYQLL 301 +Y YC N P + +S +FE R Q + L+ L+ PVQ+I KY L Sbjct: 374 IYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQ 433 Query: 302 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND-----------MMTLGRLRGFEGK-- 348 L + LKY + D D+E A+ M V + N+ + +EG+ Sbjct: 434 LAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDL 493 Query: 349 LTAQGKLL-GQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIF--SEALGGGVRGGTQPG 405 L +L+ + VT+P+A + ++R FLF+ +I+ + L V Sbjct: 494 LVRSSELIYSGELTRVTQPQA------KSQQRMFFLFDHQLIYCKKDLLRRDV------- 540 Query: 406 YVYKNSIKVSCL-------GLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWI 458 YK + + L G + +L RG G ++L P Q W+ Sbjct: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATG--DSHLLCTRKPEQKQRWL 598 Query: 459 KHVAQILESQRDFLNALQSPIEYQRRESQTNS-----LGRPRGPGVGSP 502 K A+ E + S E QR+++ N+ G+P+G +P Sbjct: 599 KAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKGRRTAAP 647 >gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] Length = 655 Score = 75.9 bits (185), Expect = 1e-13 Identities = 61/214 (28%), Positives = 108/214 (50%), Gaps = 31/214 (14%) Query: 142 TLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM-----AAQGVP 196 TLS + E E+K ++ EL+ETE+ YV L + + + + +++ P Sbjct: 93 TLSGSGTQEPEKK---------IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFP 143 Query: 197 ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI-----KHERRLHMYVV 251 E + R++F NI IY++H +FL ELQR L D W A I K L MY Sbjct: 144 EDVV---RVIFSNISSIYQFHSQFFLPELQRRLDD--WTANPRIGDVIQKLAPFLKMYSE 198 Query: 252 YCQNKPKSEHVVSEFGDS--YFEELRQQL-----GHRLQLNDLLIKPVQRIMKYQLLLKD 304 Y +N ++ +++ + D F+E+ ++ L L +++PVQRI +Y+LLLK+ Sbjct: 199 YVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKE 258 Query: 305 FLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMT 338 +++ D AD ++A++++ + N +T Sbjct: 259 YIQKLPAQAPDQADAQKALDMIFSAAQHSNAAIT 292 >gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [Homo sapiens] Length = 690 Score = 74.7 bits (182), Expect = 2e-13 Identities = 97/405 (23%), Positives = 168/405 (41%), Gaps = 55/405 (13%) Query: 131 PGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM 190 P D P + ++ +E + K + + V++E++ TE+ Y+ L I EGY+ Sbjct: 257 PADDDAPLAGNSGAEDGGAEAQSSKDQMRTN--VINEILSTERDYIKHLRDICEGYVRQC 314 Query: 191 AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQL---FIKHERRLH 247 + S + R +FGNI+ IY + + QR ++ L++L F++H+ Sbjct: 315 RKRADMFS-EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ 373 Query: 248 MYVVYCQNKPKSEHVVSEFGDS-----YFEELRQ-QLGHRLQLNDLLIKPVQRIMKYQLL 301 +Y YC N P + +S +FE R Q + L+ L+ PVQ+I KY L Sbjct: 374 IYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQ 433 Query: 302 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND-----------MMTLGRLRGFEGK-- 348 L + LKY + D D+E A+ M V + N+ + +EG+ Sbjct: 434 LAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDL 493 Query: 349 LTAQGKLL-GQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIF--SEALGGGVRGGTQPG 405 L +L+ + VT+P+A + ++R FLF+ +I+ + L V Sbjct: 494 LVRSSELIYSGELTRVTQPQA------KSQQRMFFLFDHQLIYCKKDLLRRDV------- 540 Query: 406 YVYKNSIKVSCL-------GLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWI 458 YK + + L G + +L RG G ++L P Q W+ Sbjct: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATG--DSHLLCTRKPEQKQRWL 598 Query: 459 KHVAQILESQRDFLNALQSPIEYQRRESQTNS-----LGRPRGPG 498 K A+ E + S E QR+++ N+ G+P+ G Sbjct: 599 KAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKAVG 643 >gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sapiens] Length = 1054 Score = 73.9 bits (180), Expect = 4e-13 Identities = 91/411 (22%), Positives = 163/411 (39%), Gaps = 76/411 (18%) Query: 45 SASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYE 104 S S GL P+ PSS + SP P SGL + D S + A Sbjct: 387 SISFPEGLRTPASPSSANAFYSLSPSTLVP-SGLPEFKDSSSSLTDPQVSYVKSPAAERR 445 Query: 105 NWMLEPALATGEELPELTLL--TTLLEGPGDKTQPPEEETLS-----------QAPESEE 151 + A+A G + P L L GPG T+ P+ S Q P Sbjct: 446 SG----AVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVPLGPA 501 Query: 152 EQ-------------------------KKKALERSMYVLSELVETEKMYVDDLGQIVEGY 186 EQ K+ + + +++ E++ TE+ Y+ DL I + Sbjct: 502 EQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWF 561 Query: 187 MATMAAQ-GVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLK------------DPD 233 + + + +P +L ++F NI IYE+HR FL+E+++ L Sbjct: 562 RSAVVKEDAMPATLM---TLLFSNIDPIYEFHRG-FLREVEQRLALWEGPSKAHTKGSHQ 617 Query: 234 WLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFG---------DSYFEELRQQLGHRLQL 284 + + +++ R+L + Y Q + + V++E ++ ++E Q L L Sbjct: 618 RIGDILLRNMRQLKEFTSYFQ---RHDEVLTELEKATKRCKKLEAVYKEFELQKVCYLPL 674 Query: 285 NDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMM----TLG 340 N L+KP+QR++ Y+LLL+ +Y+ D AD A++ + V ++ L Sbjct: 675 NTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQ 734 Query: 341 RLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFS 391 +L + L L+ ++ E L ++R FLF +++++ Sbjct: 735 KLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLYT 785 >gi|24797153 faciogenital dysplasia protein [Homo sapiens] Length = 961 Score = 72.0 bits (175), Expect = 1e-12 Identities = 55/221 (24%), Positives = 108/221 (48%), Gaps = 14/221 (6%) Query: 128 LEGPGDKTQPPEEETLSQAP--ESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEG 185 LE D+ + E++ P E +E + ++ ++ +EL++TEK YV L + + Sbjct: 339 LEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQV 398 Query: 186 YMATMAAQGVPESLRGRDRI--VFGNIQQIYEWHRDYFLQELQRCLKDPDW---LAQLFI 240 + A + + S D + +F NI IY +H+ + L EL++ +++ D + + Sbjct: 399 FCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQ 458 Query: 241 KHERRLHMYVVYCQNKPKSEHVVS-------EFGDSYFEELRQQLGHRLQLNDLLIKPVQ 293 K L MY Y +N ++ +V+ +F E +++ L L +++PVQ Sbjct: 459 KLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQ 518 Query: 294 RIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCN 334 RI +Y+LLLKD+L D+ D ++++E++ + N Sbjct: 519 RIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSN 559 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.136 0.410 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 26,139,460 Number of Sequences: 37866 Number of extensions: 1388679 Number of successful extensions: 10612 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 105 Number of HSP's successfully gapped in prelim test: 166 Number of HSP's that attempted gapping in prelim test: 9585 Number of HSP's gapped (non-prelim): 1055 length of query: 580 length of database: 18,247,518 effective HSP length: 108 effective length of query: 472 effective length of database: 14,157,990 effective search space: 6682571280 effective search space used: 6682571280 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.