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Search of human proteins with 150247226
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
(317 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 637 0.0
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 436 e-122
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 340 1e-93
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 333 1e-91
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 295 4e-80
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 295 4e-80
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 295 4e-80
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 295 4e-80
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 182 4e-46
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 182 4e-46
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 182 4e-46
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 163 2e-40
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi... 151 6e-37
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 102 4e-22
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 89 7e-18
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 79 7e-15
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 78 9e-15
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 75 1e-13
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 74 1e-13
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 72 8e-13
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 68 9e-12
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens] 65 1e-10
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 63 3e-10
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 63 4e-10
gi|40254992 carbonic reductase 4 [Homo sapiens] 61 1e-09
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 60 2e-09
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 60 2e-09
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 60 3e-09
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 59 4e-09
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo... 59 4e-09
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 637 bits (1642), Expect = 0.0
Identities = 317/317 (100%), Positives = 317/317 (100%)
Query: 1 MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAAC 60
MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAAC
Sbjct: 1 MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAAC 60
Query: 61 LTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTA 120
LTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTA
Sbjct: 61 LTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTA 120
Query: 121 PNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISK 180
PNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISK
Sbjct: 121 PNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISK 180
Query: 181 YGVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGE 240
YGVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGE
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGE 240
Query: 241 KFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTF 300
KFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTF
Sbjct: 241 KFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTF 300
Query: 301 LVDAIMYWVSPSPAKAL 317
LVDAIMYWVSPSPAKAL
Sbjct: 301 LVDAIMYWVSPSPAKAL 317
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 436 bits (1120), Expect = e-122
Identities = 210/317 (66%), Positives = 255/317 (80%)
Query: 1 MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAAC 60
MWLYLA FVGLYYLLHWYRERQV+SHL+DKYVFITGCDSGFG LLARQLDARGLRVLAAC
Sbjct: 1 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 60
Query: 61 LTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTA 120
LTEKGAEQLRGQTSDRLETVTLDVTK ES+AAA QWVKE V D+GLWGLVNNAGI P
Sbjct: 61 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 120
Query: 121 PNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISK 180
E L +D + +L VNL+GVI VTLS+LPLVRRARGR+VNVSS++GRV+ F GGYC+SK
Sbjct: 121 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 180
Query: 181 YGVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGE 240
YGVEAFSD LRRE+ +FGVK++++EPGYF+T +T+ + L+ + W + +KE YG+
Sbjct: 181 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 240
Query: 241 KFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTF 300
++ ++ C+ +L+LVT+CMEHAL + HPRTRYSAGWDAK ++P+SY+PT
Sbjct: 241 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 300
Query: 301 LVDAIMYWVSPSPAKAL 317
L D I+ P PA+A+
Sbjct: 301 LADYILTRSWPKPAQAV 317
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 340 bits (871), Expect = 1e-93
Identities = 162/313 (51%), Positives = 229/313 (73%)
Query: 5 LAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEK 64
+A L ++ W++ ++ +L +KYVFITGCDSGFG LLA+QL RG++VLAAC TE+
Sbjct: 1 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE 60
Query: 65 GAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNEL 124
G+++L+ TS RL+T LDVTK+ES+ AAAQWV++ V ++GLW LVNNAG+ LP+ PNE
Sbjct: 61 GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW 120
Query: 125 LTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISKYGVE 184
LTK DFV +++VNL+G+I+VTL +LP+V+RARGRVVN+SS GRV++ GGGYC+SK+GVE
Sbjct: 121 LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE 180
Query: 185 AFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVA 244
AFSDS+RREL YFGVKV +IEPG ++TA+ KE ++W+R E +++YGE +
Sbjct: 181 AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR 240
Query: 245 DYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDA 304
Y + + Q + V N MEHA+++ PR RY+ G DAKLLY+P++ +PT + D
Sbjct: 241 IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF 300
Query: 305 IMYWVSPSPAKAL 317
I+ P PA ++
Sbjct: 301 ILSRYLPRPADSV 313
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 333 bits (854), Expect = 1e-91
Identities = 167/318 (52%), Positives = 228/318 (71%), Gaps = 2/318 (0%)
Query: 1 MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAAC 60
MWL L + L+ +L R+RQ L + +VFITGCDSGFG+LLA QLD RG RVLA+C
Sbjct: 1 MWLPLLLGALLWAVLWLLRDRQSLP-ASNAFVFITGCDSGFGRLLALQLDQRGFRVLASC 59
Query: 61 LTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTA 120
LT GAE L+ S RL T LD+T +SV AA+WV+ V++ GL+GLVNNAG++
Sbjct: 60 LTPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIG 119
Query: 121 PNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISK 180
P LT+ DF +L+VN +G I VTL+LLPL+++ARGRV+N++SV+GR++ GGGYC+SK
Sbjct: 120 PTPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSK 179
Query: 181 YGVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGE 240
+G+EAFSDSLRR++++FG++V+++EPG+F+T VT+ E K+ W R P + YG
Sbjct: 180 FGLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGG 239
Query: 241 KFVADYKKSAEQ-MEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPT 299
F+ Y K ++ M C DL+ V+ C+EHAL A HPRTRYS GWDAKLL+LP SY+P
Sbjct: 240 AFLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPA 299
Query: 300 FLVDAIMYWVSPSPAKAL 317
LVDA++ WV P PA+A+
Sbjct: 300 SLVDAVLTWVLPKPAQAV 317
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 295 bits (755), Expect = 4e-80
Identities = 143/291 (49%), Positives = 202/291 (69%), Gaps = 1/291 (0%)
Query: 17 WYRERQV-LSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75
W R+ ++ + + DKY+FITGCDSGFG L AR D +G V+AACLTE G+ L+ +TS+
Sbjct: 16 WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75
Query: 76 RLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILD 135
RL TV LDVT E+V AQWVK V +KGLWGL+NNAG+ AP + LT +D+ ++
Sbjct: 76 RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135
Query: 136 VNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELS 195
VNL G+I VTL++LPLV++A+GRV+NVSSV GR+++ GGGY SKY VE F+DSLRR++
Sbjct: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195
Query: 196 YFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQ 255
FGV V+ IEPG FKT + + ++ L IW++ SP++K+ YGE ++ + +
Sbjct: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255
Query: 256 KCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIM 306
DLS V CM+HAL + P+T Y+AG DAK+ ++P+S+MP L D ++
Sbjct: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 295 bits (755), Expect = 4e-80
Identities = 143/291 (49%), Positives = 202/291 (69%), Gaps = 1/291 (0%)
Query: 17 WYRERQV-LSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75
W R+ ++ + + DKY+FITGCDSGFG L AR D +G V+AACLTE G+ L+ +TS+
Sbjct: 16 WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75
Query: 76 RLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILD 135
RL TV LDVT E+V AQWVK V +KGLWGL+NNAG+ AP + LT +D+ ++
Sbjct: 76 RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135
Query: 136 VNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELS 195
VNL G+I VTL++LPLV++A+GRV+NVSSV GR+++ GGGY SKY VE F+DSLRR++
Sbjct: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195
Query: 196 YFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQ 255
FGV V+ IEPG FKT + + ++ L IW++ SP++K+ YGE ++ + +
Sbjct: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255
Query: 256 KCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIM 306
DLS V CM+HAL + P+T Y+AG DAK+ ++P+S+MP L D ++
Sbjct: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 295 bits (755), Expect = 4e-80
Identities = 143/291 (49%), Positives = 202/291 (69%), Gaps = 1/291 (0%)
Query: 17 WYRERQV-LSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75
W R+ ++ + + DKY+FITGCDSGFG L AR D +G V+AACLTE G+ L+ +TS+
Sbjct: 16 WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75
Query: 76 RLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILD 135
RL TV LDVT E+V AQWVK V +KGLWGL+NNAG+ AP + LT +D+ ++
Sbjct: 76 RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135
Query: 136 VNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELS 195
VNL G+I VTL++LPLV++A+GRV+NVSSV GR+++ GGGY SKY VE F+DSLRR++
Sbjct: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195
Query: 196 YFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQ 255
FGV V+ IEPG FKT + + ++ L IW++ SP++K+ YGE ++ + +
Sbjct: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255
Query: 256 KCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIM 306
DLS V CM+HAL + P+T Y+AG DAK+ ++P+S+MP L D ++
Sbjct: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 295 bits (755), Expect = 4e-80
Identities = 143/291 (49%), Positives = 202/291 (69%), Gaps = 1/291 (0%)
Query: 17 WYRERQV-LSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75
W R+ ++ + + DKY+FITGCDSGFG L AR D +G V+AACLTE G+ L+ +TS+
Sbjct: 16 WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75
Query: 76 RLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILD 135
RL TV LDVT E+V AQWVK V +KGLWGL+NNAG+ AP + LT +D+ ++
Sbjct: 76 RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135
Query: 136 VNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELS 195
VNL G+I VTL++LPLV++A+GRV+NVSSV GR+++ GGGY SKY VE F+DSLRR++
Sbjct: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195
Query: 196 YFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQ 255
FGV V+ IEPG FKT + + ++ L IW++ SP++K+ YGE ++ + +
Sbjct: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255
Query: 256 KCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIM 306
DLS V CM+HAL + P+T Y+AG DAK+ ++P+S+MP L D ++
Sbjct: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 182 bits (461), Expect = 4e-46
Identities = 110/264 (41%), Positives = 159/264 (60%), Gaps = 16/264 (6%)
Query: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEK----GAEQLRGQTSDRLETVTLDVT 85
K V +TGCDSGFG LA+ L ++G V A CL + G ++L SDRL TV L+V
Sbjct: 56 KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
Query: 86 KTESVAAAAQWVKECVRD--KGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVID 143
+E V + V+ ++D KG+WGLVNNAGIS E + + + + +VNL G +
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWGTVR 174
Query: 144 VTLSLLPLVRRARGRVVNVSSVMGRV-SLFGGGYCISKYGVEAFSDSLRRELSYFGVKVA 202
+T S LPL+RRA+GRVVN+SS++GR+ + YCI+K+GVEAFSD LR E+ GVKV+
Sbjct: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
Query: 203 MIEPGYF--KTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQ- 259
++EPG F T++ S E ++W+ V++ YG+K+ + + +ME C+
Sbjct: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKY---FDEKIAKMETYCSSG 291
Query: 260 --DLSLVTNCMEHALIACHPRTRY 281
D S V + + HAL A P TRY
Sbjct: 292 STDTSPVIDAVTHALTATTPYTRY 315
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 182 bits (461), Expect = 4e-46
Identities = 110/264 (41%), Positives = 159/264 (60%), Gaps = 16/264 (6%)
Query: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEK----GAEQLRGQTSDRLETVTLDVT 85
K V +TGCDSGFG LA+ L ++G V A CL + G ++L SDRL TV L+V
Sbjct: 56 KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
Query: 86 KTESVAAAAQWVKECVRD--KGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVID 143
+E V + V+ ++D KG+WGLVNNAGIS E + + + + +VNL G +
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWGTVR 174
Query: 144 VTLSLLPLVRRARGRVVNVSSVMGRV-SLFGGGYCISKYGVEAFSDSLRRELSYFGVKVA 202
+T S LPL+RRA+GRVVN+SS++GR+ + YCI+K+GVEAFSD LR E+ GVKV+
Sbjct: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
Query: 203 MIEPGYF--KTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQ- 259
++EPG F T++ S E ++W+ V++ YG+K+ + + +ME C+
Sbjct: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKY---FDEKIAKMETYCSSG 291
Query: 260 --DLSLVTNCMEHALIACHPRTRY 281
D S V + + HAL A P TRY
Sbjct: 292 STDTSPVIDAVTHALTATTPYTRY 315
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 182 bits (461), Expect = 4e-46
Identities = 110/264 (41%), Positives = 159/264 (60%), Gaps = 16/264 (6%)
Query: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEK----GAEQLRGQTSDRLETVTLDVT 85
K V +TGCDSGFG LA+ L ++G V A CL + G ++L SDRL TV L+V
Sbjct: 56 KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
Query: 86 KTESVAAAAQWVKECVRD--KGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVID 143
+E V + V+ ++D KG+WGLVNNAGIS E + + + + +VNL G +
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWGTVR 174
Query: 144 VTLSLLPLVRRARGRVVNVSSVMGRV-SLFGGGYCISKYGVEAFSDSLRRELSYFGVKVA 202
+T S LPL+RRA+GRVVN+SS++GR+ + YCI+K+GVEAFSD LR E+ GVKV+
Sbjct: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
Query: 203 MIEPGYF--KTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQ- 259
++EPG F T++ S E ++W+ V++ YG+K+ + + +ME C+
Sbjct: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKY---FDEKIAKMETYCSSG 291
Query: 260 --DLSLVTNCMEHALIACHPRTRY 281
D S V + + HAL A P TRY
Sbjct: 292 STDTSPVIDAVTHALTATTPYTRY 315
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 163 bits (413), Expect = 2e-40
Identities = 104/303 (34%), Positives = 159/303 (52%), Gaps = 4/303 (1%)
Query: 5 LAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEK 64
L +F +L++ Y Q L + K V +TG D G G L + LD G V A L E
Sbjct: 58 LILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNEN 117
Query: 65 G--AEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPN 122
G AE+LR S RL + +D+TK + A V ++D+GLW ++NNAG+
Sbjct: 118 GPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDG 177
Query: 123 ELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFG-GGYCISKY 181
ELL D+ + VN G ++VT + LPL+R+++GR+VNVSS+ G + Y SK
Sbjct: 178 ELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKA 237
Query: 182 GVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVT-SKERFLKSFLEIWDRSSPEVKEAYGE 240
V FS +R ELS +G+KVA I+PG F T + + +++ K +I D EV+E YG+
Sbjct: 238 AVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQ 297
Query: 241 KFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTF 300
++ + + ++D S V ++HA++A P Y+ G A L Y+P
Sbjct: 298 DYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIG 357
Query: 301 LVD 303
+ D
Sbjct: 358 IYD 360
>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
sapiens]
Length = 405
Score = 151 bits (382), Expect = 6e-37
Identities = 99/271 (36%), Positives = 143/271 (52%), Gaps = 4/271 (1%)
Query: 32 VFITGCDSGFGKLLARQLDARGLRVLAACL--TEKGAEQLRGQTSDRLETVTLDVTKTES 89
V ITGCDSGFGK A++LD+ G VLA L GA +LR S RL + +D+TK
Sbjct: 85 VLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGD 144
Query: 90 VAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLL 149
++ ++ K GLWGLVNNAG + A EL F + ++VN G +++T LL
Sbjct: 145 ISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLL 204
Query: 150 PLVRRARGRVVNVSSVMGRVSL-FGGGYCISKYGVEAFSDSLRRELSYFGVKVAMIEPGY 208
PL+R +RGR+V V S G + G Y SK V D+ EL +GVKV++I+PG
Sbjct: 205 PLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGC 264
Query: 209 FKT-AVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQDLSLVTNC 267
FKT +V + ++ K + E+ +AYG+ ++ + DL+ V +
Sbjct: 265 FKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDA 324
Query: 268 MEHALIACHPRTRYSAGWDAKLLYLPMSYMP 298
+ AL+A PR RY G L+Y Y+P
Sbjct: 325 ITDALLAARPRRRYYPGQGLGLMYFIHYYLP 355
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 102 bits (254), Expect = 4e-22
Identities = 74/219 (33%), Positives = 117/219 (53%), Gaps = 20/219 (9%)
Query: 5 LAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEK 64
L VF GL+ LL W R + ++LR+ V ITG SG GK A+ A G + L C
Sbjct: 32 LGVF-GLFRLLQWVRGK---AYLRNAVVVITGATSGLGKECAKVFYAAGAK-LVLCGRNG 86
Query: 65 GA-----EQLRGQTSDRLET-----VTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAG 114
GA +L + +++T VT D+T + ++ AAA + +C + LVNNAG
Sbjct: 87 GALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LVNNAG 144
Query: 115 ISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLLP-LVRRARGRVVNVSSVMGRVSL-F 172
IS + D +++ N G + +T +LLP +++R +G +V +SS+ G++S+ F
Sbjct: 145 ISYRGTIMDTTVDVD-KRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPF 203
Query: 173 GGGYCISKYGVEAFSDSLRRELSYFGVKVAMIEPGYFKT 211
Y SK+ +AF D LR E+ + ++V +I PGY T
Sbjct: 204 RSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHT 242
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 88.6 bits (218), Expect = 7e-18
Identities = 88/261 (33%), Positives = 127/261 (48%), Gaps = 23/261 (8%)
Query: 32 VFITGCDSGFGKLLARQL---DARGLRVLAAC--LTEKG----AEQLRGQTSDRLETVTL 82
V ITGC SG G LA +L ++ +V A L +G A + LET+ L
Sbjct: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
Query: 83 DVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVI 142
DV ++SVAAA + V E D LV NAG+ L P E L + ++LDVN++G +
Sbjct: 66 DVRDSKSVAAARERVTEGRVDV----LVCNAGLGL-LGPLEALGEDAVASVLDVNVVGTV 120
Query: 143 DVTLSLLP-LVRRARGRVVNVSSVMGRVSL-FGGGYCISKYGVEAFSDSLRRELSYFGVK 200
+ + LP + RR GRV+ SV G + L F YC SK+ +E +SL L FGV
Sbjct: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
Query: 201 VAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQD 260
+++IE G TA E+ L S E+ DR+ + + Y ++Q+ ++ Q+
Sbjct: 181 LSLIECGPVHTAF--MEKVLGSPEEVLDRTDIHTFHRFYQ-----YLAHSKQVFREAAQN 233
Query: 261 LSLVTNCMEHALIACHPRTRY 281
V AL A P RY
Sbjct: 234 PEEVAEVFLTALRAPKPTLRY 254
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 78.6 bits (192), Expect = 7e-15
Identities = 66/194 (34%), Positives = 99/194 (51%), Gaps = 15/194 (7%)
Query: 32 VFITGCDSGFGKLLARQL--DARGLRVLAACLTEKGA-EQLRGQTSDRL-ETVT---LDV 84
V I+GC SG G LA QL D + + A + + G E L + L +T+T LDV
Sbjct: 8 VLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDV 67
Query: 85 TKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDV 144
ESVA C++ + + LVNNAG+ L P E L+ + D N G + +
Sbjct: 68 CSDESVAQCLS----CIQGE-VDVLVNNAGMGL-VGPLEGLSLAAMQNVFDTNFFGAVRL 121
Query: 145 TLSLLP-LVRRARGRVVNVSSVMGRVS-LFGGGYCISKYGVEAFSDSLRRELSYFGVKVA 202
++LP + RR +G +V +SSVMG +F Y SK+ +E F +SL +L F + ++
Sbjct: 122 VKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFIS 181
Query: 203 MIEPGYFKTAVTSK 216
++EPG T K
Sbjct: 182 LVEPGPVVTEFEGK 195
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 78.2 bits (191), Expect = 9e-15
Identities = 76/230 (33%), Positives = 105/230 (45%), Gaps = 27/230 (11%)
Query: 27 LRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLT----EKGAEQLRGQTSDRLETV-T 81
L K V ITG ++G GK AR+L +RG RV AC E A ++R T + V
Sbjct: 37 LPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRK 96
Query: 82 LDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGV 141
LD++ T+S+ A A+ +K L L+NNAG+ + T F T L VN LG
Sbjct: 97 LDLSDTKSIRAFAEGF--LAEEKQLHILINNAGVMMCPYSK---TADGFETHLGVNHLGH 151
Query: 142 IDVTLSLLPLVR-RARGRVVNVSSV---MGRVSLF----------GGGYCISKYGVEAFS 187
+T LL ++ A RVVNVSSV +G++ G YC SK F+
Sbjct: 152 FLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFT 211
Query: 188 DSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEA 237
L + L GV + PG ++ + L +W SP VK A
Sbjct: 212 RELAKRLQGTGVTTYAVHPGVVRSELVRHSSLL---CLLWRLFSPFVKTA 258
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 74.7 bits (182), Expect = 1e-13
Identities = 58/180 (32%), Positives = 88/180 (48%), Gaps = 6/180 (3%)
Query: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTES 89
K V +TG G G + R G RV+ E G L + + + DVT+ +
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-FILCDVTQEDD 68
Query: 90 VAAAAQWVKECVRDKG-LWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSL 148
V V E +R G L +VNNAG P E + Q F +L++NLLG +T
Sbjct: 69 VKTL---VSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLA 125
Query: 149 LPLVRRARGRVVNVSSVMGRVSLFGG-GYCISKYGVEAFSDSLRRELSYFGVKVAMIEPG 207
LP +R+++G V+N+SS++G + Y +K V A + +L + S +GV+V I PG
Sbjct: 126 LPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPG 185
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 74.3 bits (181), Expect = 1e-13
Identities = 60/193 (31%), Positives = 106/193 (54%), Gaps = 17/193 (8%)
Query: 27 LRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDR-------LET 79
L D V++TG SG G+ LA QL G+ ++ + E+++ + + +
Sbjct: 48 LTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILV 107
Query: 80 VTLDVTKTESVAAAAQWVKECVRDKG-LWGLVNNAGISLPTAPNELLTKQD-FVTILDVN 137
+ LD+T T S AA K +++ G + LVNN G+S + + T D + ++++N
Sbjct: 108 LPLDLTDTGSHEAA---TKAVLQEFGRIDILVNNGGMSQRSLCMD--TSLDVYRKLIELN 162
Query: 138 LLGVIDVTLSLLP-LVRRARGRVVNVSSVMGRVSL-FGGGYCISKYGVEAFSDSLRREL- 194
LG + +T +LP ++ R +G++V V+S++G +S+ GYC SK+ + F + LR EL
Sbjct: 163 YLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELA 222
Query: 195 SYFGVKVAMIEPG 207
+Y G+ V+ I PG
Sbjct: 223 TYPGIIVSNICPG 235
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 71.6 bits (174), Expect = 8e-13
Identities = 68/214 (31%), Positives = 101/214 (47%), Gaps = 24/214 (11%)
Query: 27 LRDKYVFITGCDSGFGKLLARQLDARGLRVLAACL-TEKG---AEQLRGQTSDRLETV-T 81
L K V +TG ++G GK A++L RG RV AC EKG A++++ T ++ V
Sbjct: 39 LPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRK 98
Query: 82 LDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGV 141
LD++ T+S+ A A+ +K L L+NNAG+ + T F + VN LG
Sbjct: 99 LDLSDTKSIRAFAKGF--LAEEKHLHVLINNAGVMMCPYSK---TADGFEMHIGVNHLGH 153
Query: 142 IDVT-LSLLPLVRRARGRVVNVSSV---MGRVSLF----------GGGYCISKYGVEAFS 187
+T L L L A R+VNVSS+ +GR+ G YC SK F+
Sbjct: 154 FLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFT 213
Query: 188 DSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLK 221
L R L GV + PG ++ + F++
Sbjct: 214 QELARRLKGSGVTTYSVHPGTVQSELVRHSSFMR 247
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 68.2 bits (165), Expect = 9e-12
Identities = 62/221 (28%), Positives = 107/221 (48%), Gaps = 22/221 (9%)
Query: 7 VFVGLYYLLHWYRERQVL---SHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTE 63
+ +G+ LL Y+E L S +++K V IT SG GK AR G R++ L
Sbjct: 12 LLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTGGARLV---LCG 68
Query: 64 KGAEQLRG------QTSDRLETVT-----LDVTKTESVAAAAQWVKECVRDKGLWGLVNN 112
K E+L +D +T T LD++ V A+ V +C + L+NN
Sbjct: 69 KNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDI--LINN 126
Query: 113 AGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLLP-LVRRARGRVVNVSSVMGRVSL 171
A + + +++ + D I+D N G I +T +LLP ++ R G++V V+++ G+ +
Sbjct: 127 ASVKVKGPAHKISLELD-KKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGI 185
Query: 172 -FGGGYCISKYGVEAFSDSLRRELSYFGVKVAMIEPGYFKT 211
F Y SK+ F D LR E+ + V ++ + P + ++
Sbjct: 186 PFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRS 226
>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
Length = 335
Score = 64.7 bits (156), Expect = 1e-10
Identities = 54/192 (28%), Positives = 92/192 (47%), Gaps = 16/192 (8%)
Query: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAAC----LTEKGAEQLRGQTSDRLETVTLDVT 85
K FITG +G GK + L + G + + A + + AEQ+ QT +++ + DV
Sbjct: 60 KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
Query: 86 KTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVT 145
+ V V E ++ G +V N +P E L+ + TI D+ L G VT
Sbjct: 120 DPDMVQNT---VSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVT 176
Query: 146 LSL-LPLVRRARGRV-VNVSSVMGRVSLFGGGYCI----SKYGVEAFSDSLRRELSYFGV 199
L + L++ +G ++++++ G G+ + +K GVEA S SL E +G+
Sbjct: 177 LEIGKQLIKAQKGAAFLSITTIYAET---GSGFVVPSASAKAGVEAMSKSLAAEWGKYGM 233
Query: 200 KVAMIEPGYFKT 211
+ +I+PG KT
Sbjct: 234 RFNVIQPGPIKT 245
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 63.2 bits (152), Expect = 3e-10
Identities = 58/195 (29%), Positives = 90/195 (46%), Gaps = 20/195 (10%)
Query: 32 VFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQ----LRGQTSDRLETVTLDVTKT 87
V ITG SG G+LLA Q G ++ + ++G E+ R + R+ T D ++
Sbjct: 43 VLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQK 102
Query: 88 ESVAAAAQWVKECVRDKGLWGLVNNAGI----SLPTAPNELLTKQDFVTILDVNLLGVID 143
E V A VK+ V D + L+NNAGI P+EL+ K DVN +
Sbjct: 103 EGVYRVADQVKKEVGDVSI--LINNAGIVTGKKFLDCPDELMEKS-----FDVNFKAHLW 155
Query: 144 VTLSLLP-LVRRARGRVVNVSSVMGRVSLFG-GGYCISKYGVEAFSDSLRREL---SYFG 198
+ LP ++ G +V +SS G + G YC SK+ F++S+ E G
Sbjct: 156 TYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKG 215
Query: 199 VKVAMIEPGYFKTAV 213
+K ++ P + KT +
Sbjct: 216 IKTTIVCPFFIKTGM 230
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 62.8 bits (151), Expect = 4e-10
Identities = 54/211 (25%), Positives = 93/211 (44%), Gaps = 21/211 (9%)
Query: 22 QVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQL----------RG 71
Q+ + LR +TG SG G+ ++ +L G V A L A++ G
Sbjct: 4 QLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEG 63
Query: 72 QTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELL---TKQ 128
DV++ + + V+ C + +V+ AGI+ +E L ++
Sbjct: 64 PPRGNHAAFQADVSEARAARCLLEQVQACF-SRPPSVVVSCAGIT----QDEFLLHMSED 118
Query: 129 DFVTILDVNLLGVIDVTLSLLPLV--RRARGRVVNVSSVMGRVSLFGG-GYCISKYGVEA 185
D+ ++ VNL G VT + + RG ++N+SS++G+V G Y SK GV
Sbjct: 119 DWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIG 178
Query: 186 FSDSLRRELSYFGVKVAMIEPGYFKTAVTSK 216
+ + REL G++ + PG+ T +T K
Sbjct: 179 LTQTAARELGRHGIRCNSVLPGFIATPMTQK 209
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 60.8 bits (146), Expect = 1e-09
Identities = 53/197 (26%), Positives = 93/197 (47%), Gaps = 7/197 (3%)
Query: 29 DKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTE 88
DK + G G G+ +A+ + +G R+ +GA+ G + DV K
Sbjct: 2 DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEH 61
Query: 89 SVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLG-VIDVTLS 147
V + +++ + LVN AGI+ T +D V+ L NLLG ++ +
Sbjct: 62 DVQNTFEELEKHLGRVNF--LVNAAGINRDGLLVRTKT-EDMVSQLHTNLLGSMLTCKAA 118
Query: 148 LLPLVRRARGRVVNVSSVMGRVSLFGGG-YCISKYGVEAFSDSLRRELSYFGVKVAMIEP 206
+ ++++ G +VNV S++G G Y SK G+ FS +L +E++ ++V ++ P
Sbjct: 119 MRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAP 178
Query: 207 GYFKTAVTS--KERFLK 221
G+ T +T KE LK
Sbjct: 179 GFVHTDMTKDLKEEHLK 195
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 60.5 bits (145), Expect = 2e-09
Identities = 52/207 (25%), Positives = 96/207 (46%), Gaps = 10/207 (4%)
Query: 4 YLAVFVGLYYLLHWYRERQVL--SHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACL 61
YL +GL+ ++Y + L+ K V +TG G G+ +A L G V+ +
Sbjct: 7 YLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVV---V 63
Query: 62 TEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKG-LWGLVNNAGISLPTA 120
T + E L+ S LE + ++ V G L G ++ ++ T
Sbjct: 64 TARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITN 123
Query: 121 PNELLTKQDFVTI---LDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSL-FGGGY 176
+ L D + ++VN L + +T++ LP+++++ G +V VSS+ G+V+ Y
Sbjct: 124 TSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAY 183
Query: 177 CISKYGVEAFSDSLRRELSYFGVKVAM 203
SK+ ++ F S+R+E S V V++
Sbjct: 184 SASKFALDGFFSSIRKEYSVSRVNVSI 210
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 60.5 bits (145), Expect = 2e-09
Identities = 52/207 (25%), Positives = 96/207 (46%), Gaps = 10/207 (4%)
Query: 4 YLAVFVGLYYLLHWYRERQVL--SHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACL 61
YL +GL+ ++Y + L+ K V +TG G G+ +A L G V+ +
Sbjct: 7 YLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVV---V 63
Query: 62 TEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKG-LWGLVNNAGISLPTA 120
T + E L+ S LE + ++ V G L G ++ ++ T
Sbjct: 64 TARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITN 123
Query: 121 PNELLTKQDFVTI---LDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSL-FGGGY 176
+ L D + ++VN L + +T++ LP+++++ G +V VSS+ G+V+ Y
Sbjct: 124 TSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAY 183
Query: 177 CISKYGVEAFSDSLRRELSYFGVKVAM 203
SK+ ++ F S+R+E S V V++
Sbjct: 184 SASKFALDGFFSSIRKEYSVSRVNVSI 210
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 60.1 bits (144), Expect = 3e-09
Identities = 60/202 (29%), Positives = 91/202 (45%), Gaps = 25/202 (12%)
Query: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAAC----LTEKGAEQLRGQT-SDRLETVTLDV 84
K V +TG ++G GK A +L RG ++ AC E A+ +RG+T + + LD+
Sbjct: 39 KTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDL 98
Query: 85 TKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDV 144
+S+ A + E ++ + L+NNAG+ P+ T+ F VN LG +
Sbjct: 99 ASLKSIREFAAKIIE--EEERVDILINNAGVM--RCPH-WTTEDGFEMQFGVNHLGHFLL 153
Query: 145 TLSLL-PLVRRARGRVVNVSS---VMGRVSL-----------FGGGYCISKYGVEAFSDS 189
T LL L A R++N+SS V G + YC SK + F+
Sbjct: 154 TNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKE 213
Query: 190 LRRELSYFGVKVAMIEPGYFKT 211
L R L GV V + PG +T
Sbjct: 214 LSRRLQGSGVTVNALHPGVART 235
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 59.3 bits (142), Expect = 4e-09
Identities = 61/223 (27%), Positives = 102/223 (45%), Gaps = 39/223 (17%)
Query: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVT---K 86
++ +TG G GK A +L G++V+ L ++ D+L+ V+ ++ K
Sbjct: 51 EWAVVTGSTDGIGKSYAEELAKHGMKVV-----------LISRSKDKLDQVSSEIKEKFK 99
Query: 87 TESVAAAAQWVKECVRDK---GLWG-----LVNNAGISLPTAPNELLTKQDFVTI----L 134
E+ A + E + DK GL G LVNN G+S P L D + +
Sbjct: 100 VETRTIAVDFASEDIYDKIKTGLAGLEIGILVNNVGMSY-EYPEYFLDVPDLDNVIKKMI 158
Query: 135 DVNLLGVIDVTLSLLP-LVRRARGRVVNVSSVMGRVSL-FGGGYCISKYGVEAFSDSLRR 192
++N+L V +T +LP +V R++G ++N+SS G + + Y +K V+ FS L
Sbjct: 159 NINILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHE 218
Query: 193 ELSYFGVKVAMIEPGYFKTAVT----------SKERFLKSFLE 225
E GV V + P + T + S E F+KS ++
Sbjct: 219 EYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIK 261
>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
sapiens]
Length = 330
Score = 59.3 bits (142), Expect = 4e-09
Identities = 51/198 (25%), Positives = 97/198 (48%), Gaps = 10/198 (5%)
Query: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLET--VTLDVTKT 87
++ ++G G GK A +L +RGL ++ L + E+L+ D +T V D+
Sbjct: 68 RWAVVSGATDGIGKAYAEELASRGLNII---LISRNEEKLQVVAKDIADTYKVETDIIVA 124
Query: 88 ESVAAAAQW--VKECVRDKGLWGLVNNAGISLPTAPN-ELLTKQDFVTILDVNLLGVIDV 144
+ + + ++E ++DK + LVNN G+ P L++ I++VN+ +
Sbjct: 125 DFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLM 184
Query: 145 TLSLLP-LVRRARGRVVNVSS-VMGRVSLFGGGYCISKYGVEAFSDSLRRELSYFGVKVA 202
+LP +V R +G +V +SS + + + SK ++ FS +L+ E + G+ V
Sbjct: 185 VHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQ 244
Query: 203 MIEPGYFKTAVTSKERFL 220
+ P Y T++T+ FL
Sbjct: 245 SLIPFYVATSMTAPSNFL 262
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,926,766
Number of Sequences: 37866
Number of extensions: 429831
Number of successful extensions: 1006
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 899
Number of HSP's gapped (non-prelim): 73
length of query: 317
length of database: 18,247,518
effective HSP length: 102
effective length of query: 215
effective length of database: 14,385,186
effective search space: 3092814990
effective search space used: 3092814990
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.