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Search of human proteins with 150010577
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150010577 tyrosine kinase, non-receptor, 1 [Homo sapiens]
(661 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150010577 tyrosine kinase, non-receptor, 1 [Homo sapiens] 1363 0.0
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 378 e-104
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 374 e-103
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 183 5e-46
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 183 5e-46
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 178 2e-44
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 178 2e-44
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 178 2e-44
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 178 2e-44
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 177 3e-44
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 177 3e-44
gi|29725609 epidermal growth factor receptor isoform a precursor... 176 6e-44
gi|221316650 ephrin receptor EphA1 [Homo sapiens] 169 6e-42
gi|54792098 erbB-2 isoform b [Homo sapiens] 167 4e-41
gi|54792096 erbB-2 isoform a [Homo sapiens] 167 4e-41
gi|4758282 ephrin receptor EphA7 [Homo sapiens] 166 8e-41
gi|4503787 fyn-related kinase [Homo sapiens] 165 1e-40
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 165 1e-40
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 161 2e-39
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 160 3e-39
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 160 5e-39
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap... 160 5e-39
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 160 5e-39
gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens] 159 6e-39
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 157 3e-38
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] 157 3e-38
gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo sapi... 157 3e-38
gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2... 156 7e-38
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 156 7e-38
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 155 1e-37
>gi|150010577 tyrosine kinase, non-receptor, 1 [Homo sapiens]
Length = 661
Score = 1363 bits (3527), Expect = 0.0
Identities = 661/661 (100%), Positives = 661/661 (100%)
Query: 1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS 60
MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
Sbjct: 1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS 60
Query: 61 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE 120
EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
Sbjct: 61 EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE 120
Query: 121 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV 180
LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
Sbjct: 121 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV 180
Query: 181 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG 240
LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
Sbjct: 181 LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG 240
Query: 241 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF 300
LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
Sbjct: 241 LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF 300
Query: 301 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW 360
SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
Sbjct: 301 SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW 360
Query: 361 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQ 420
APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQ
Sbjct: 361 APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQ 420
Query: 421 NGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPAR 480
NGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPAR
Sbjct: 421 NGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPAR 480
Query: 481 GQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSS 540
GQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSS
Sbjct: 481 GQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSS 540
Query: 541 SPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGV 600
SPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGV
Sbjct: 541 SPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGV 600
Query: 601 THQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLAR 660
THQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLAR
Sbjct: 601 THQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLAR 660
Query: 661 P 661
P
Sbjct: 661 P 661
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo
sapiens]
Length = 1086
Score = 378 bits (970), Expect = e-104
Identities = 241/599 (40%), Positives = 334/599 (55%), Gaps = 48/599 (8%)
Query: 1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS 60
M PE G+ WLL+LL ++QL Q++ + ++LNVTR HF++VK EDL+ IGMGRP QRRL
Sbjct: 64 MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW 123
Query: 61 EALKRLRSGPKSKNWVYKILGG------FAPEHKEPTLPSDSPRHL-PEPEGGLK---CL 110
EA+KR ++ K K+W+ K+ G F P H + T SP P EG L+ CL
Sbjct: 124 EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL 183
Query: 111 IPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTE-LGDFLREV 169
I E + E LG G FGVV RG W PSGK+V VAVK L+ P+ E + DF+REV
Sbjct: 184 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLK--PDVLSQPEAMDDFIREV 241
Query: 170 SVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQL 229
+ M +L+H +++RL+G+VL P++MV ELAPLGSL RL L+ L + Q+
Sbjct: 242 NAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGH--FLLGTLSRYAVQV 299
Query: 230 AGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAW 289
A M YL ++ +HRDLA RNLLLA+ +K+ DFGL+R L YVM R +P+AW
Sbjct: 300 AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW 359
Query: 290 CAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLE-DRARLPRPPLC 348
CAPESL+ FS ASD WMFGVTLWEMF+ G+EPW G+ IL +++ + RLPRP C
Sbjct: 360 CAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDC 419
Query: 349 SRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVI 408
+ +Y++ ++CWA P DRP+F L L EA P++ ++D EP L ++ D ITVI
Sbjct: 420 PQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVI 479
Query: 409 EGSPDSTIWKGQNGRTFKVGSFPASAVT-LADAGGLPATRPVHRGTPARGDQHPGSIDGD 467
EG ++ W+GQN RT VG FP + VT +A ++P+ G GD
Sbjct: 480 EGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTG-------HGD 532
Query: 468 RKKANLWDAPPARGQ-RRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQ 526
+ W P + P++ +S L + S P+ GG V +
Sbjct: 533 SDPRHCWGFPDRIDELYLGNPMDPPDLLSVELST--SRPPQHLGG------------VKR 578
Query: 527 GPPGLPPRPPLSSSSPQPSQPSRERLPWPK-------RKPPHNHPMGMPGARKAAALSG 578
PP PP+P + P S ++ P RKP P G+ A+ +A + G
Sbjct: 579 EPPPRPPQPAFFTQKPTYDPVSEDQDPLSSDFKRLGLRKP--GLPRGLWLAKPSARVPG 635
Score = 34.3 bits (77), Expect = 0.38
Identities = 14/34 (41%), Positives = 22/34 (64%)
Query: 625 VDQLFHLSSRSRADCWRILEHYQWDLSAASRYVL 658
V+QLF L R R +C ++LE + W+L A ++L
Sbjct: 1043 VEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLL 1076
Score = 33.1 bits (74), Expect = 0.84
Identities = 27/104 (25%), Positives = 42/104 (40%), Gaps = 9/104 (8%)
Query: 477 PPARGQRRNMPLERMKGISRSLESVL-SLGPRPTGGGSSPPEIRQARAVPQGP-PGLPPR 534
PP+ Q + + R L++ S P P+ GG P++ P+ P P P R
Sbjct: 775 PPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQV-----PPRVPIPPRPTR 829
Query: 535 PPLSSSSPQPSQPSRERLPWPKRKP--PHNHPMGMPGARKAAAL 576
P + S P + + P P P P P+ G+R + L
Sbjct: 830 PHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPL 873
Score = 32.0 bits (71), Expect = 1.9
Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 17/66 (25%)
Query: 502 LSLGPRPTG--------GGSSPPEIRQARAV-PQG--------PPGLPPRPPLSSSSPQP 544
+ L P P G G +SPP + + PQG PPG P PP SSSP
Sbjct: 832 VQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGK 891
Query: 545 SQPSRE 550
+ P+ +
Sbjct: 892 TMPTTQ 897
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
sapiens]
Length = 1038
Score = 374 bits (959), Expect = e-103
Identities = 210/448 (46%), Positives = 283/448 (63%), Gaps = 16/448 (3%)
Query: 1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS 60
M PE G+ WLL+LL ++QL Q++ + ++LNVTR HF++VK EDL+ IGMGRP QRRL
Sbjct: 1 MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW 60
Query: 61 EALKRLRSGPKSKNWVYKILGG------FAPEHKEPTLPSDSPRHL-PEPEGGLK---CL 110
EA+KR ++ K K+W+ K+ G F P H + T SP P EG L+ CL
Sbjct: 61 EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL 120
Query: 111 IPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTE-LGDFLREV 169
I E + E LG G FGVV RG W PSGK+V VAVK L+ P+ E + DF+REV
Sbjct: 121 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLK--PDVLSQPEAMDDFIREV 178
Query: 170 SVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQL 229
+ M +L+H +++RL+G+VL P++MV ELAPLGSL RL L+ L + Q+
Sbjct: 179 NAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGH--FLLGTLSRYAVQV 236
Query: 230 AGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAW 289
A M YL ++ +HRDLA RNLLLA+ +K+ DFGL+R L YVM R +P+AW
Sbjct: 237 AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW 296
Query: 290 CAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLE-DRARLPRPPLC 348
CAPESL+ FS ASD WMFGVTLWEMF+ G+EPW G+ IL +++ + RLPRP C
Sbjct: 297 CAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDC 356
Query: 349 SRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVI 408
+ +Y++ ++CWA P DRP+F L L EA P++ ++D EP L ++ D ITVI
Sbjct: 357 PQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVI 416
Query: 409 EGSPDSTIWKGQNGRTFKVGSFPASAVT 436
EG ++ W+GQN RT VG FP + VT
Sbjct: 417 EGRAENYWWRGQNTRTLCVGPFPRNVVT 444
Score = 68.2 bits (165), Expect = 2e-11
Identities = 52/156 (33%), Positives = 78/156 (50%), Gaps = 18/156 (11%)
Query: 518 IRQARAVPQGPPGLPPR---PPLSSSSPQPSQPSRERLPWPKR----KPPHNHPMGMPGA 570
+R+A++ P+ P LP PP S+P P+ P+ P P+ K + PGA
Sbjct: 876 LREAQS-PEEPTPLPVPLLLPP--PSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGA 932
Query: 571 RKAAALSGGLLSD-------PELQRKIMEVELS-VHGVTHQECQTALGATGGDVVSAIRN 622
R + L PE R +++++ VHGVT +ECQ AL G V A +
Sbjct: 933 RPPPPRATARLPQRGCPGDGPEAGRPADKIQMAMVHGVTTEECQAALQCHGWSVQRAAQY 992
Query: 623 LKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVL 658
LKV+QLF L R R +C ++LE + W+L A ++L
Sbjct: 993 LKVEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLL 1028
Score = 33.1 bits (74), Expect = 0.84
Identities = 27/104 (25%), Positives = 42/104 (40%), Gaps = 9/104 (8%)
Query: 477 PPARGQRRNMPLERMKGISRSLESVL-SLGPRPTGGGSSPPEIRQARAVPQGP-PGLPPR 534
PP+ Q + + R L++ S P P+ GG P++ P+ P P P R
Sbjct: 697 PPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQV-----PPRVPIPPRPTR 751
Query: 535 PPLSSSSPQPSQPSRERLPWPKRKP--PHNHPMGMPGARKAAAL 576
P + S P + + P P P P P+ G+R + L
Sbjct: 752 PHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPL 795
Score = 32.0 bits (71), Expect = 1.9
Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 17/66 (25%)
Query: 502 LSLGPRPTG--------GGSSPPEIRQARAV-PQG--------PPGLPPRPPLSSSSPQP 544
+ L P P G G +SPP + + PQG PPG P PP SSSP
Sbjct: 754 VQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGK 813
Query: 545 SQPSRE 550
+ P+ +
Sbjct: 814 TMPTTQ 819
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 183 bits (464), Expect = 5e-46
Identities = 99/259 (38%), Positives = 151/259 (58%), Gaps = 7/259 (2%)
Query: 119 GELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHP 178
G +G G FG VH+G++ P ++ VA+K+ + + + FL+E M +HP
Sbjct: 447 GRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREK---FLQEALTMRQFDHP 503
Query: 179 HVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGA 238
H+++L G++ P+ ++MEL LG L + L + L +A L L+ QL+ A+AYL +
Sbjct: 504 HIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYS--LDLASLILYAYQLSTALAYLES 561
Query: 239 RGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHG 298
+ VHRD+A RN+L++S +K+ DFGL R + + Y +P W APES+
Sbjct: 562 KRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDST--YYKASKGKLPIKWMAPESINFR 619
Query: 299 AFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALR 358
F+SASDVWMFGV +WE+ G +P+ GV ++ R+E+ RLP PP C LYSL +
Sbjct: 620 RFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTK 679
Query: 359 CWAPHPADRPSFSHLEGLL 377
CWA P+ RP F+ L+ L
Sbjct: 680 CWAYDPSRRPRFTELKAQL 698
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 183 bits (464), Expect = 5e-46
Identities = 99/259 (38%), Positives = 151/259 (58%), Gaps = 7/259 (2%)
Query: 119 GELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHP 178
G +G G FG VH+G++ P ++ VA+K+ + + + FL+E M +HP
Sbjct: 425 GRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREK---FLQEALTMRQFDHP 481
Query: 179 HVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGA 238
H+++L G++ P+ ++MEL LG L + L + L +A L L+ QL+ A+AYL +
Sbjct: 482 HIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYS--LDLASLILYAYQLSTALAYLES 539
Query: 239 RGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHG 298
+ VHRD+A RN+L++S +K+ DFGL R + + Y +P W APES+
Sbjct: 540 KRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDST--YYKASKGKLPIKWMAPESINFR 597
Query: 299 AFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALR 358
F+SASDVWMFGV +WE+ G +P+ GV ++ R+E+ RLP PP C LYSL +
Sbjct: 598 RFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTK 657
Query: 359 CWAPHPADRPSFSHLEGLL 377
CWA P+ RP F+ L+ L
Sbjct: 658 CWAYDPSRRPRFTELKAQL 676
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 178 bits (451), Expect = 2e-44
Identities = 104/285 (36%), Positives = 155/285 (54%), Gaps = 7/285 (2%)
Query: 89 EPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVK 148
E + ++ P GG + I V +LG G FG V+ G++T G+ + VAVK
Sbjct: 398 ESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVK 457
Query: 149 SLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARL 208
+ + + F+ E +M NL+HPH+++L G++ +P ++MEL P G L L
Sbjct: 458 TCK---KDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYL 514
Query: 209 TAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVR 268
+ L V L L+ Q+ AMAYL + VHRD+A RN+L+ASP +K+ DFGL R
Sbjct: 515 ERNKNS--LKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSR 572
Query: 269 PLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVP 328
+ Y +P W +PES+ F++ASDVWMF V +WE+ S G++P+ +
Sbjct: 573 YIEDED--YYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLE 630
Query: 329 PYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL 373
++ LE RLP+P LC LY+L RCW P+DRP F+ L
Sbjct: 631 NKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 178 bits (451), Expect = 2e-44
Identities = 104/285 (36%), Positives = 155/285 (54%), Gaps = 7/285 (2%)
Query: 89 EPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVK 148
E + ++ P GG + I V +LG G FG V+ G++T G+ + VAVK
Sbjct: 398 ESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVK 457
Query: 149 SLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARL 208
+ + + F+ E +M NL+HPH+++L G++ +P ++MEL P G L L
Sbjct: 458 TCK---KDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYL 514
Query: 209 TAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVR 268
+ L V L L+ Q+ AMAYL + VHRD+A RN+L+ASP +K+ DFGL R
Sbjct: 515 ERNKNS--LKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSR 572
Query: 269 PLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVP 328
+ Y +P W +PES+ F++ASDVWMF V +WE+ S G++P+ +
Sbjct: 573 YIEDED--YYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLE 630
Query: 329 PYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL 373
++ LE RLP+P LC LY+L RCW P+DRP F+ L
Sbjct: 631 NKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 178 bits (451), Expect = 2e-44
Identities = 104/285 (36%), Positives = 155/285 (54%), Gaps = 7/285 (2%)
Query: 89 EPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVK 148
E + ++ P GG + I V +LG G FG V+ G++T G+ + VAVK
Sbjct: 398 ESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVK 457
Query: 149 SLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARL 208
+ + + F+ E +M NL+HPH+++L G++ +P ++MEL P G L L
Sbjct: 458 TCK---KDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYL 514
Query: 209 TAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVR 268
+ L V L L+ Q+ AMAYL + VHRD+A RN+L+ASP +K+ DFGL R
Sbjct: 515 ERNKNS--LKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSR 572
Query: 269 PLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVP 328
+ Y +P W +PES+ F++ASDVWMF V +WE+ S G++P+ +
Sbjct: 573 YIEDED--YYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLE 630
Query: 329 PYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL 373
++ LE RLP+P LC LY+L RCW P+DRP F+ L
Sbjct: 631 NKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 178 bits (451), Expect = 2e-44
Identities = 104/285 (36%), Positives = 155/285 (54%), Gaps = 7/285 (2%)
Query: 89 EPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVK 148
E + ++ P GG + I V +LG G FG V+ G++T G+ + VAVK
Sbjct: 398 ESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVK 457
Query: 149 SLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARL 208
+ + + F+ E +M NL+HPH+++L G++ +P ++MEL P G L L
Sbjct: 458 TCK---KDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYL 514
Query: 209 TAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVR 268
+ L V L L+ Q+ AMAYL + VHRD+A RN+L+ASP +K+ DFGL R
Sbjct: 515 ERNKNS--LKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSR 572
Query: 269 PLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVP 328
+ Y +P W +PES+ F++ASDVWMF V +WE+ S G++P+ +
Sbjct: 573 YIEDED--YYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLE 630
Query: 329 PYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL 373
++ LE RLP+P LC LY+L RCW P+DRP F+ L
Sbjct: 631 NKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 177 bits (449), Expect = 3e-44
Identities = 106/289 (36%), Positives = 160/289 (55%), Gaps = 18/289 (6%)
Query: 89 EPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSV--PVA 146
EP PS + P ++ E + R ++LGSG FG V++G+W +P G++V PVA
Sbjct: 696 EPLTPSGTA-----PNQAQLRILKETELKRVKVLGSGAFGTVYKGIW-VPEGETVKIPVA 749
Query: 147 VKSLR--VGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSL 204
+K L GP+ + +F+ E +M +++HPH++RL G+ L +Q+V +L P G L
Sbjct: 750 IKILNETTGPKANV-----EFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCL 804
Query: 205 HARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADF 264
+ + LL + Q+A M YL R LVHRDLA RN+L+ SP +K+ DF
Sbjct: 805 LEYVHEHKDN--IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDF 862
Query: 265 GLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPW 324
GL R L G Y G + +P W A E + + F+ SDVW +GVT+WE+ + G +P+
Sbjct: 863 GLARLLEGDEKEYNADGGK-MPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY 921
Query: 325 AGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL 373
G+P I LE RLP+PP+C+ +Y + ++CW RP F L
Sbjct: 922 DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKEL 970
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 177 bits (449), Expect = 3e-44
Identities = 106/289 (36%), Positives = 160/289 (55%), Gaps = 18/289 (6%)
Query: 89 EPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSV--PVA 146
EP PS + P ++ E + R ++LGSG FG V++G+W +P G++V PVA
Sbjct: 696 EPLTPSGTA-----PNQAQLRILKETELKRVKVLGSGAFGTVYKGIW-VPEGETVKIPVA 749
Query: 147 VKSLR--VGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSL 204
+K L GP+ + +F+ E +M +++HPH++RL G+ L +Q+V +L P G L
Sbjct: 750 IKILNETTGPKANV-----EFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCL 804
Query: 205 HARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADF 264
+ + LL + Q+A M YL R LVHRDLA RN+L+ SP +K+ DF
Sbjct: 805 LEYVHEHKDN--IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDF 862
Query: 265 GLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPW 324
GL R L G Y G + +P W A E + + F+ SDVW +GVT+WE+ + G +P+
Sbjct: 863 GLARLLEGDEKEYNADGGK-MPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY 921
Query: 325 AGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL 373
G+P I LE RLP+PP+C+ +Y + ++CW RP F L
Sbjct: 922 DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKEL 970
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 176 bits (446), Expect = 6e-44
Identities = 105/287 (36%), Positives = 155/287 (54%), Gaps = 14/287 (4%)
Query: 89 EPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSV--PVA 146
EP PS P L ++ E + ++LGSG FG V++GLW +P G+ V PVA
Sbjct: 690 EPLTPSGEA-----PNQALLRILKETEFKKIKVLGSGAFGTVYKGLW-IPEGEKVKIPVA 743
Query: 147 VKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHA 206
+K LR E+ D E VM ++++PHV RL G+ L +Q++ +L P G L
Sbjct: 744 IKELREATSPKANKEILD---EAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLD 800
Query: 207 RLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGL 266
+ + L + Q+A M YL R LVHRDLA RN+L+ +P+ +K+ DFGL
Sbjct: 801 YVREHKDN--IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGL 858
Query: 267 VRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAG 326
+ LG Y G + +P W A ES+ H ++ SDVW +GVT+WE+ + G +P+ G
Sbjct: 859 AKLLGAEEKEYHAEGGK-VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 917
Query: 327 VPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL 373
+P I LE RLP+PP+C+ +Y + ++CW RP F L
Sbjct: 918 IPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFREL 964
>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
Length = 976
Score = 169 bits (429), Expect = 6e-42
Identities = 99/260 (38%), Positives = 142/260 (54%), Gaps = 7/260 (2%)
Query: 121 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV 180
++G G FG V+RG LPS VA+K+L+ + G + +FLRE ++M HPH+
Sbjct: 629 VIGEGEFGEVYRGTLRLPSQDCKTVAIKTLK---DTSPGGQWWNFLREATIMGQFSHPHI 685
Query: 181 LRLHGLVLGQ-PLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGAR 239
L L G+V + P+ ++ E G+L A L L+ L L+ +A M YL
Sbjct: 686 LHLEGVVTKRKPIMIITEFMENGALDAFLREREDQ--LVPGQLVAMLQGIASGMNYLSNH 743
Query: 240 GLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGA 299
VHRDLA RN+L+ KV+DFGL R L G Y G + IP W APE++ H
Sbjct: 744 NYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGK-IPIRWTAPEAIAHRI 802
Query: 300 FSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRC 359
F++ASDVW FG+ +WE+ S G++P+ + +++ +ED RLP P C LY L C
Sbjct: 803 FTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNC 862
Query: 360 WAPHPADRPSFSHLEGLLQE 379
WA A RP F L+ L++
Sbjct: 863 WAYDRARRPHFQKLQAHLEQ 882
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 167 bits (422), Expect = 4e-41
Identities = 150/520 (28%), Positives = 231/520 (44%), Gaps = 45/520 (8%)
Query: 89 EPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSV--PVA 146
EP PS + P ++ E + + ++LGSG FG V++G+W +P G++V PVA
Sbjct: 668 EPLTPSGAM-----PNQAQMRILKETELRKVKVLGSGAFGTVYKGIW-IPDGENVKIPVA 721
Query: 147 VKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSL-- 204
+K LR E+ D E VM + P+V RL G+ L +Q+V +L P G L
Sbjct: 722 IKVLRENTSPKANKEILD---EAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLD 778
Query: 205 HARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADF 264
H R L L + Q+A M+YL LVHRDLA RN+L+ SP +K+ DF
Sbjct: 779 HVRENRGR----LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDF 834
Query: 265 GLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPW 324
GL R L Y G + +P W A ES+ F+ SDVW +GVT+WE+ + G +P+
Sbjct: 835 GLARLLDIDETEYHADGGK-VPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPY 893
Query: 325 AGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL--EGLLQEAGP 382
G+P I LE RLP+PP+C+ +Y + ++CW RP F L E P
Sbjct: 894 DGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDP 953
Query: 383 SEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQNGRTFKVGSF-PASAVTLADAG 441
+++ A +++ +++E + + + G F P A AG
Sbjct: 954 QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPA---PGAG 1010
Query: 442 GLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPARGQRRNM-PLERMKGISRSLES 500
G+ R T + G ++ ++A P+ G ++ + G ++ L+S
Sbjct: 1011 GMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQS 1070
Query: 501 VLSLGPRPTGGGSSPPE----------IRQARAVPQ----GPPGLPPRPPLSSSSPQP-S 545
+ + P P S P + PQ P + P+PP P P +
Sbjct: 1071 LPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAA 1130
Query: 546 QPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPE 585
+P+ L PK P G G K GG + +PE
Sbjct: 1131 RPAGATLERPKTLSP-----GKNGVVKDVFAFGGAVENPE 1165
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 167 bits (422), Expect = 4e-41
Identities = 150/520 (28%), Positives = 231/520 (44%), Gaps = 45/520 (8%)
Query: 89 EPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSV--PVA 146
EP PS + P ++ E + + ++LGSG FG V++G+W +P G++V PVA
Sbjct: 698 EPLTPSGAM-----PNQAQMRILKETELRKVKVLGSGAFGTVYKGIW-IPDGENVKIPVA 751
Query: 147 VKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSL-- 204
+K LR E+ D E VM + P+V RL G+ L +Q+V +L P G L
Sbjct: 752 IKVLRENTSPKANKEILD---EAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLD 808
Query: 205 HARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADF 264
H R L L + Q+A M+YL LVHRDLA RN+L+ SP +K+ DF
Sbjct: 809 HVRENRGR----LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDF 864
Query: 265 GLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPW 324
GL R L Y G + +P W A ES+ F+ SDVW +GVT+WE+ + G +P+
Sbjct: 865 GLARLLDIDETEYHADGGK-VPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPY 923
Query: 325 AGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL--EGLLQEAGP 382
G+P I LE RLP+PP+C+ +Y + ++CW RP F L E P
Sbjct: 924 DGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDP 983
Query: 383 SEACCVRDVTEPGALRMETGDPITVIEGSPDSTIWKGQNGRTFKVGSF-PASAVTLADAG 441
+++ A +++ +++E + + + G F P A AG
Sbjct: 984 QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPA---PGAG 1040
Query: 442 GLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPARGQRRNM-PLERMKGISRSLES 500
G+ R T + G ++ ++A P+ G ++ + G ++ L+S
Sbjct: 1041 GMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQS 1100
Query: 501 VLSLGPRPTGGGSSPPE----------IRQARAVPQ----GPPGLPPRPPLSSSSPQP-S 545
+ + P P S P + PQ P + P+PP P P +
Sbjct: 1101 LPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAA 1160
Query: 546 QPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPE 585
+P+ L PK P G G K GG + +PE
Sbjct: 1161 RPAGATLERPKTLSP-----GKNGVVKDVFAFGGAVENPE 1195
>gi|4758282 ephrin receptor EphA7 [Homo sapiens]
Length = 998
Score = 166 bits (419), Expect = 8e-41
Identities = 100/261 (38%), Positives = 145/261 (55%), Gaps = 8/261 (3%)
Query: 121 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV 180
++G+G FG V G LP + V VA+K+L+VG + DFL E S+M +HP+V
Sbjct: 638 VIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEK---QRRDFLCEASIMGQFDHPNV 694
Query: 181 LRLHGLVL-GQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGAR 239
+ L G+V G+P+ +V+E G+L A L V L LR +A M YL
Sbjct: 695 VHLEGVVTRGKPVMIVIEFMENGALDAFLRKH--DGQFTVIQLVGMLRGIAAGMRYLADM 752
Query: 240 GLVHRDLATRNLLLASPRTIKVADFGLVRPL-GGARGRYVMGGPRPIPYAWCAPESLRHG 298
G VHRDLA RN+L+ S KV+DFGL R + Y G + IP W APE++++
Sbjct: 753 GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGK-IPVRWTAPEAIQYR 811
Query: 299 AFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALR 358
F+SASDVW +G+ +WE+ S GE P+ + +++ +E+ RLP P C L+ L L
Sbjct: 812 KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLD 871
Query: 359 CWAPHPADRPSFSHLEGLLQE 379
CW A+RP F + G+L +
Sbjct: 872 CWQKERAERPKFEQIVGILDK 892
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 165 bits (418), Expect = 1e-40
Identities = 98/260 (37%), Positives = 139/260 (53%), Gaps = 12/260 (4%)
Query: 122 LGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVL 181
LGSG FG V GLW + PVAVK+L+ G P DFLRE +M NL HP ++
Sbjct: 240 LGSGQFGEVWEGLWN----NTTPVAVKTLKPGSMDP-----NDFLREAQIMKNLRHPKLI 290
Query: 182 RLHGL-VLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG 240
+L+ + L P+ ++ EL GSL L + L + + Q+A MAYL +R
Sbjct: 291 QLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDM-AAQVASGMAYLESRN 349
Query: 241 LVHRDLATRNLLLASPRTIKVADFGLVRPLG-GARGRYVMGGPRPIPYAWCAPESLRHGA 299
+HRDLA RN+L+ KVADFGL R Y +P W APE++R
Sbjct: 350 YIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNK 409
Query: 300 FSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRC 359
FS SDVW FG+ L+E+ + G+ P++G+ ++Q L RLP+P C + Y++ L C
Sbjct: 410 FSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLEC 469
Query: 360 WAPHPADRPSFSHLEGLLQE 379
W P +RP+F L L++
Sbjct: 470 WNAEPKERPTFETLRWKLED 489
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 165 bits (417), Expect = 1e-40
Identities = 104/284 (36%), Positives = 152/284 (53%), Gaps = 18/284 (6%)
Query: 120 ELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPH 179
+++G+G FG V G LPS K + VA+K+L+VG + DFL E S+M +HP+
Sbjct: 625 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEK---QRRDFLGEASIMGQFDHPN 681
Query: 180 VLRLHGLVL-GQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGA 238
++RL G+V +P+ +V E GSL + L V L LR +A M YL
Sbjct: 682 IIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKH--DAQFTVIQLVGMLRGIASGMKYLSD 739
Query: 239 RGLVHRDLATRNLLLASPRTIKVADFGLVRPL-GGARGRYVMGGPRPIPYAWCAPESLRH 297
G VHRDLA RN+L+ S KV+DFGL R L Y G + IP W +PE++ +
Sbjct: 740 MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGK-IPIRWTSPEAIAY 798
Query: 298 GAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLAL 357
F+SASDVW +G+ LWE+ S GE P+ + +++ +++ RLP P C ALY L L
Sbjct: 799 RKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLML 858
Query: 358 RCWAPHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMET 401
CW +RP F + +L + + PG+L++ T
Sbjct: 859 DCWQKDRNNRPKFEQIVSILDKL----------IRNPGSLKIIT 892
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 161 bits (408), Expect = 2e-39
Identities = 105/273 (38%), Positives = 149/273 (54%), Gaps = 15/273 (5%)
Query: 122 LGSGCFGVVHRGLWT-LPSGK-SVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPH 179
LG G FG+V+ GL L +G+ S PVA+K++ E E +FL+E SVM + H
Sbjct: 985 LGQGSFGMVYEGLARGLEAGEESTPVALKTVN---ELASPRECIEFLKEASVMKAFKCHH 1041
Query: 180 VLRLHGLVL-GQPLQMVMELAPLGSLHARLTAPAPT-------PPLLVALLCLFLRQLAG 231
V+RL G+V GQP ++MEL G L + L + P P + + ++A
Sbjct: 1042 VVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIAD 1101
Query: 232 AMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCA 291
MAYL A VHRDLA RN +++ T+K+ DFG+ R + Y GG +P W A
Sbjct: 1102 GMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYET-DYYRKGGKGLLPVRWMA 1160
Query: 292 PESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRA 351
PESL+ G F++ SDVW FGV LWE+ + E+P+ G+ +L+ + D L C
Sbjct: 1161 PESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQ 1220
Query: 352 LYSLALRCWAPHPADRPSFSH-LEGLLQEAGPS 383
L L RCW P+P RPSF+H L+ + +E PS
Sbjct: 1221 LQELMSRCWQPNPRLRPSFTHILDSIQEELRPS 1253
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 160 bits (406), Expect = 3e-39
Identities = 106/286 (37%), Positives = 143/286 (50%), Gaps = 20/286 (6%)
Query: 89 EPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVK 148
+P +P +PR P G LG G FG V GLW S+PVA+K
Sbjct: 210 QPCMPQKAPRQDVWER-------PHSEFALGRKLGEGYFGEVWEGLWL----GSLPVAIK 258
Query: 149 SLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLG-QPLQMVMELAPLGSLHAR 207
++ +L D +E+ + L H ++RLH + G +P+ +V EL G+L A
Sbjct: 259 VIKSA-----NMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAF 313
Query: 208 LTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLV 267
L P L LL F Q+A M+YL + +VHRDLA RN+L+ KVADFGL
Sbjct: 314 LGTPEGRALRLPPLLG-FACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLA 372
Query: 268 RPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGV 327
R L Y IP W APE+ + FS SDVW FGV L E+F+ G+ P+ G+
Sbjct: 373 RLLKD--DIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGM 430
Query: 328 PPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL 373
+ LQ++ RLPRP C +Y L L CW P +RPSF+ L
Sbjct: 431 TNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATL 476
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
sapiens]
Length = 1015
Score = 160 bits (404), Expect = 5e-39
Identities = 98/261 (37%), Positives = 139/261 (53%), Gaps = 8/261 (3%)
Query: 121 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV 180
++G+G FG V G LP + +PVA+K+L+VG + DFL E S+M +HP++
Sbjct: 658 VIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK---QRRDFLGEASIMGQFDHPNI 714
Query: 181 LRLHGLVL-GQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGAR 239
+ L G+V +P+ +V E GSL L V L LR ++ M YL
Sbjct: 715 IHLEGVVTKSKPVMIVTEYMENGSLDTFLKKN--DGQFTVIQLVGMLRGISAGMKYLSDM 772
Query: 240 GLVHRDLATRNLLLASPRTIKVADFGLVRPL-GGARGRYVMGGPRPIPYAWCAPESLRHG 298
G VHRDLA RN+L+ S KV+DFGL R L Y G + IP W APE++
Sbjct: 773 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGK-IPIRWTAPEAIAFR 831
Query: 299 AFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALR 358
F+SASDVW +G+ +WE+ S GE P+ + +++ +E+ RLP P C ALY L L
Sbjct: 832 KFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLD 891
Query: 359 CWAPHPADRPSFSHLEGLLQE 379
CW RP F + +L +
Sbjct: 892 CWQKERNSRPKFDEIVNMLDK 912
>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
sapiens]
Length = 1037
Score = 160 bits (404), Expect = 5e-39
Identities = 98/261 (37%), Positives = 139/261 (53%), Gaps = 8/261 (3%)
Query: 121 LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV 180
++G+G FG V G LP + +PVA+K+L+VG + DFL E S+M +HP++
Sbjct: 680 VIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK---QRRDFLGEASIMGQFDHPNI 736
Query: 181 LRLHGLVL-GQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGAR 239
+ L G+V +P+ +V E GSL L V L LR ++ M YL
Sbjct: 737 IHLEGVVTKSKPVMIVTEYMENGSLDTFLKKN--DGQFTVIQLVGMLRGISAGMKYLSDM 794
Query: 240 GLVHRDLATRNLLLASPRTIKVADFGLVRPL-GGARGRYVMGGPRPIPYAWCAPESLRHG 298
G VHRDLA RN+L+ S KV+DFGL R L Y G + IP W APE++
Sbjct: 795 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGK-IPIRWTAPEAIAFR 853
Query: 299 AFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALR 358
F+SASDVW +G+ +WE+ S GE P+ + +++ +E+ RLP P C ALY L L
Sbjct: 854 KFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLD 913
Query: 359 CWAPHPADRPSFSHLEGLLQE 379
CW RP F + +L +
Sbjct: 914 CWQKERNSRPKFDEIVNMLDK 934
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 160 bits (404), Expect = 5e-39
Identities = 97/272 (35%), Positives = 145/272 (53%), Gaps = 9/272 (3%)
Query: 111 IPEGAVCRGELLGSGCFGVVHRGLWTLPSGKS-VPVAVKSLRVGPEGPMGTELGDFLREV 169
I V R +++G+G FG V++G+ SGK VPVA+K+L+ G DFL E
Sbjct: 608 IHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRV---DFLGEA 664
Query: 170 SVMMNLEHPHVLRLHGLVLG-QPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQ 228
+M H +++RL G++ +P+ ++ E G+L L V L LR
Sbjct: 665 GIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREK--DGEFSVLQLVGMLRG 722
Query: 229 LAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPL-GGARGRYVMGGPRPIPY 287
+A M YL VHRDLA RN+L+ S KV+DFGL R L Y G + IP
Sbjct: 723 IAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGK-IPI 781
Query: 288 AWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPL 347
W APE++ + F+SASDVW FG+ +WE+ + GE P+ + + +++ + D RLP P
Sbjct: 782 RWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMD 841
Query: 348 CSRALYSLALRCWAPHPADRPSFSHLEGLLQE 379
C A+Y L ++CW A RP F+ + +L +
Sbjct: 842 CPSAIYQLMMQCWQQERARRPKFADIVSILDK 873
>gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
Length = 890
Score = 159 bits (403), Expect = 6e-39
Identities = 104/274 (37%), Positives = 139/274 (50%), Gaps = 13/274 (4%)
Query: 110 LIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREV 169
LIPE G +LG G FG V G V VAVK L+ + +++ +FLRE
Sbjct: 512 LIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKA--DIIASSDIEEFLREA 569
Query: 170 SVMMNLEHPHVLRLHGLVLGQ------PLQMV-MELAPLGSLHARLTAP--APTP-PLLV 219
+ M +HPHV +L G+ L P+ MV + G LHA L A P L +
Sbjct: 570 ACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPL 629
Query: 220 ALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVM 279
L F+ +A M YL +R +HRDLA RN +LA T+ VADFGL R + Y
Sbjct: 630 QTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSG-DYYRQ 688
Query: 280 GGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDR 339
G +P W A ESL ++ SDVW FGVT+WE+ + G+ P+AG+ I L
Sbjct: 689 GCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGG 748
Query: 340 ARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL 373
RL +PP C +Y L +CW+ P RPSF+ L
Sbjct: 749 NRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCL 782
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 157 bits (397), Expect = 3e-38
Identities = 103/307 (33%), Positives = 153/307 (49%), Gaps = 21/307 (6%)
Query: 82 GFAPEHKEPTLPSDSPRHLP-----------EPEG--GLKCLIPEGAVCRGEL-LGSGCF 127
G+ PE T P D PR +P +PE K + + ++ LG G F
Sbjct: 291 GYTPEPARITSP-DKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNF 349
Query: 128 GVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLV 187
G V +G++ + K + VA+K L+ G E + + +RE +M L++P+++RL G+
Sbjct: 350 GSVRQGVYRMRK-KQIDVAIKVLKQGTEK---ADTEEMMREAQIMHQLDNPYIVRLIGVC 405
Query: 188 LGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLA 247
+ L +VME+A G LH L P V+ + L Q++ M YL + VHRDLA
Sbjct: 406 QAEALMLVMEMAGGGPLHKFLVGKREEIP--VSNVAELLHQVSMGMKYLEEKNFVHRDLA 463
Query: 248 TRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVW 307
RN+LL + K++DFGL + LG Y P W APE + FSS SDVW
Sbjct: 464 ARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVW 523
Query: 308 MFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADR 367
+GVT+WE S G++P+ + ++ +E R+ PP C LY+L CW DR
Sbjct: 524 SYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDR 583
Query: 368 PSFSHLE 374
P F +E
Sbjct: 584 PDFLTVE 590
>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
Length = 1342
Score = 157 bits (397), Expect = 3e-38
Identities = 103/292 (35%), Positives = 155/292 (53%), Gaps = 19/292 (6%)
Query: 86 EHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSV-- 143
E EP PS+ + L + E + + ++LGSG FG VH+G+W +P G+S+
Sbjct: 685 ESIEPLDPSEKANKV------LARIFKETELRKLKVLGSGVFGTVHKGVW-IPEGESIKI 737
Query: 144 PVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGS 203
PV +K + + D + + +L+H H++RL GL G LQ+V + PLGS
Sbjct: 738 PVCIKVIEDKSGRQSFQAVTDHMLAIG---SLDHAHIVRLLGLCPGSSLQLVTQYLPLGS 794
Query: 204 L--HARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKV 261
L H R A P LL+ + Q+A M YL G+VHR+LA RN+LL SP ++V
Sbjct: 795 LLDHVRQHRGALGPQLLLN----WGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQV 850
Query: 262 ADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGE 321
ADFG V L + ++ P W A ES+ G ++ SDVW +GVT+WE+ + G
Sbjct: 851 ADFG-VADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGA 909
Query: 322 EPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL 373
EP+AG+ + LE RL +P +C+ +Y + ++CW RP+F L
Sbjct: 910 EPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKEL 961
>gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo
sapiens]
Length = 1005
Score = 157 bits (397), Expect = 3e-38
Identities = 100/260 (38%), Positives = 137/260 (52%), Gaps = 8/260 (3%)
Query: 120 ELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPH 179
+++GSG G V G +P + VPVA+K+L+ G + DFL E S+M +HP+
Sbjct: 639 KIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTE---RQRRDFLSEASIMGQFDHPN 695
Query: 180 VLRLHGLVL-GQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGA 238
++RL G+V G+ +V E GSL L + L LR + M YL
Sbjct: 696 IIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTH--DGQFTIMQLVGMLRGVGAGMRYLSD 753
Query: 239 RGLVHRDLATRNLLLASPRTIKVADFGLVRPL-GGARGRYVMGGPRPIPYAWCAPESLRH 297
G VHRDLA RN+L+ S KV+DFGL R L Y G + IP W APE++
Sbjct: 754 LGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGK-IPIRWTAPEAIAF 812
Query: 298 GAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLAL 357
FSSASDVW FGV +WE+ + GE P+ + ++ +E+ RLP P C AL+ L L
Sbjct: 813 RTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLML 872
Query: 358 RCWAPHPADRPSFSHLEGLL 377
CW A RP FS + +L
Sbjct: 873 DCWHKDRAQRPRFSQIVSVL 892
>gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2
[Homo sapiens]
Length = 312
Score = 156 bits (394), Expect = 7e-38
Identities = 91/253 (35%), Positives = 134/253 (52%), Gaps = 6/253 (2%)
Query: 122 LGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVL 181
LG G FG V +G++ + K + VA+K L+ G E + + +RE +M L++P+++
Sbjct: 37 LGCGNFGSVRQGVYRMRK-KQIDVAIKVLKQGTEK---ADTEEMMREAQIMHQLDNPYIV 92
Query: 182 RLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGL 241
RL G+ + L +VME+A G LH L P V+ + L Q++ M YL +
Sbjct: 93 RLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIP--VSNVAELLHQVSMGMKYLEEKNF 150
Query: 242 VHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFS 301
VHRDLA RN+LL + K++DFGL + LG Y P W APE + FS
Sbjct: 151 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 210
Query: 302 SASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWA 361
S SDVW +GVT+WE S G++P+ + ++ +E R+ PP C LY+L CW
Sbjct: 211 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWI 270
Query: 362 PHPADRPSFSHLE 374
DRP F +E
Sbjct: 271 YKWEDRPDFLTVE 283
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 156 bits (394), Expect = 7e-38
Identities = 94/263 (35%), Positives = 138/263 (52%), Gaps = 8/263 (3%)
Query: 120 ELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPH 179
E++G+G FG V++G LP + + VA+K+L+ G + DFL E S+M +HP+
Sbjct: 623 EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK---QRRDFLSEASIMGQFDHPN 679
Query: 180 VLRLHGLVL-GQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGA 238
++RL G+V +P+ ++ E G+L + L V L LR +A M YL
Sbjct: 680 IIRLEGVVTKSRPVMIITEFMENGALDSFLRQN--DGQFTVIQLVGMLRGIAAGMKYLAE 737
Query: 239 RGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARG--RYVMGGPRPIPYAWCAPESLR 296
VHRDLA RN+L+ S KV+DFGL R L Y IP W APE++
Sbjct: 738 MNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIA 797
Query: 297 HGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLA 356
+ F+SASDVW +G+ +WE+ S GE P+ + ++ +E RLP P C AL+ L
Sbjct: 798 YRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLM 857
Query: 357 LRCWAPHPADRPSFSHLEGLLQE 379
L CW RP F+ + L +
Sbjct: 858 LDCWQKDRNSRPRFAEIVNTLDK 880
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 155 bits (392), Expect = 1e-37
Identities = 105/306 (34%), Positives = 156/306 (50%), Gaps = 23/306 (7%)
Query: 84 APEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSV 143
AP+ +PT+ SP + K + + LG G +G V+ G+W S+
Sbjct: 217 APKRNKPTVYGVSPNYD-------KWEMERTDITMKHKLGGGQYGEVYEGVW---KKYSL 266
Query: 144 PVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQP-LQMVMELAPLG 202
VAVK+L+ E M E+ +FL+E +VM ++HP++++L G+ +P ++ E G
Sbjct: 267 TVAVKTLK---EDTM--EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYG 321
Query: 203 SLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVA 262
+L L V LL + Q++ AM YL + +HRDLA RN L+ +KVA
Sbjct: 322 NLLDYLRECNRQEVNAVVLLYM-ATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVA 380
Query: 263 DFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEE 322
DFGL R + G Y P W APESL + FS SDVW FGV LWE+ + G
Sbjct: 381 DFGLSRLMTG--DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMS 438
Query: 323 PWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHL----EGLLQ 378
P+ G+ + + LE R+ RP C +Y L CW +P+DRPSF+ + E + Q
Sbjct: 439 PYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 498
Query: 379 EAGPSE 384
E+ S+
Sbjct: 499 ESSISD 504
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.138 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,668,488
Number of Sequences: 37866
Number of extensions: 2008602
Number of successful extensions: 17720
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 722
Number of HSP's successfully gapped in prelim test: 843
Number of HSP's that attempted gapping in prelim test: 10915
Number of HSP's gapped (non-prelim): 5173
length of query: 661
length of database: 18,247,518
effective HSP length: 109
effective length of query: 552
effective length of database: 14,120,124
effective search space: 7794308448
effective search space used: 7794308448
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.