Guide to the Human Genome
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Name: ZAP70 Sequence: fasta or formatted (619aa) NCBI GI: 31455611
Description:

zeta-chain associated protein kinase 70kDa isoform 1

Referenced in:

Dual-Specificity Phosphatases
Non-Receptor Tyrosine Kinase Pathways

Other entries for this name:
alt prot [312aa] zeta-chain associated protein kinase 70kDa isoform 2
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             8.7         54           3
 C cysteine            2.7         17           1
 D aspartate           5.0         31           2
 E glutamate           7.4         46           2
 F phenylalanine       2.9         18           2
 G glycine             6.8         42           3
 H histidine           2.6         16           2
 I isoleucine          3.9         24           2
 K lysine              6.8         42           2
 L leucine            10.0         62           2
 M methionine          3.4         21           2
 N asparagine          2.3         14           1
 P proline             6.8         42           2
 Q glutamine           3.7         23           1
 R arginine            6.0         37           2
 S serine              6.1         38           2
 T threonine           3.7         23           2
 V valine              4.7         29           1
 W tryptophan          1.5          9           1
 Y tyrosine            5.0         31           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   zeta-chain associated protein kinase 70kDa isoform 1... 
SYK                   0.537   spleen tyrosine kinase isoform 2 
SYK                   0.531   spleen tyrosine kinase isoform 1 
ZAP70                 0.493   zeta-chain associated protein kinase 70kDa isoform 2...
ABL1                  0.163   c-abl oncogene 1, receptor tyrosine kinase isoform a...
ABL1                  0.163   c-abl oncogene 1, receptor tyrosine kinase isoform b...
ABL2                  0.160   arg tyrosine kinase isoform c 
ABL2                  0.160   arg tyrosine kinase isoform b 
ABL2                  0.160   arg tyrosine kinase isoform e 
ABL2                  0.160   arg tyrosine kinase isoform d 
ABL2                  0.160   arg tyrosine kinase isoform a 
PTK2                  0.152   PTK2 protein tyrosine kinase 2 isoform b 
PTK2                  0.152   PTK2 protein tyrosine kinase 2 isoform a 
SRC                   0.150   proto-oncogene tyrosine-protein kinase SRC 
SRC                   0.150   proto-oncogene tyrosine-protein kinase SRC 
HCK                   0.148   hemopoietic cell kinase isoform p61HCK 
EPHA3                 0.146   ephrin receptor EphA3 isoform a precursor 
EPHB1                 0.146   ephrin receptor EphB1 precursor 
LCK                   0.145   lymphocyte-specific protein tyrosine kinase precurs...
LCK                   0.145   lymphocyte-specific protein tyrosine kinase precurs...
EPHA5                 0.144   ephrin receptor EphA5 isoform b precursor 
EPHA5                 0.144   ephrin receptor EphA5 isoform a precursor 
FYN                   0.144   protein-tyrosine kinase fyn isoform b 
EPHB2                 0.144   ephrin receptor EphB2 isoform 2 precursor 
EPHB2                 0.144   ephrin receptor EphB2 isoform 1 precursor 
FRK                   0.144   fyn-related kinase 
EPHA2                 0.143   ephrin receptor EphA2 
FYN                   0.143   protein-tyrosine kinase fyn isoform a 
EPHB4                 0.141   EPH receptor B4 precursor 
FER                   0.141   fer (fps/fes related) tyrosine kinase 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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