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Search of human proteins with 148747859
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
(923 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 1870 0.0
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 1782 0.0
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 1782 0.0
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 814 0.0
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 814 0.0
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 379 e-105
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 262 1e-69
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 155 2e-37
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 146 8e-35
gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchan... 126 8e-29
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 107 5e-23
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 107 5e-23
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 87 9e-17
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 87 9e-17
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 84 8e-16
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 83 1e-15
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 83 1e-15
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 83 1e-15
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 82 3e-15
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 79 1e-14
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 79 1e-14
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 79 1e-14
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 79 3e-14
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 79 3e-14
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 78 3e-14
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 72 2e-12
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 70 7e-12
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 70 9e-12
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 67 8e-11
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 67 8e-11
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 1870 bits (4843), Expect = 0.0
Identities = 923/923 (100%), Positives = 923/923 (100%)
Query: 1 MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL 60
MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL
Sbjct: 1 MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL 60
Query: 61 EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK 120
EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK
Sbjct: 61 EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK 120
Query: 121 YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ 180
YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ
Sbjct: 121 YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ 180
Query: 181 FYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL 240
FYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL
Sbjct: 181 FYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL 240
Query: 241 LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL 300
LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL
Sbjct: 241 LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL 300
Query: 301 VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG 360
VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG
Sbjct: 301 VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG 360
Query: 361 KVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSD 420
KVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSD
Sbjct: 361 KVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSD 420
Query: 421 FLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSML 480
FLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSML
Sbjct: 421 FLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSML 480
Query: 481 HTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWL 540
HTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWL
Sbjct: 481 HTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWL 540
Query: 541 PNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV 600
PNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV
Sbjct: 541 PNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV 600
Query: 601 LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDL 660
LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDL
Sbjct: 601 LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDL 660
Query: 661 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT 720
VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT
Sbjct: 661 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT 720
Query: 721 ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV 780
ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV
Sbjct: 721 ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV 780
Query: 781 RKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE 840
RKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE
Sbjct: 781 RKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE 840
Query: 841 KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWA 900
KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWA
Sbjct: 841 KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWA 900
Query: 901 YVQQLKVIDNQRELSRLSRELEP 923
YVQQLKVIDNQRELSRLSRELEP
Sbjct: 901 YVQQLKVIDNQRELSRLSRELEP 923
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 1782 bits (4615), Expect = 0.0
Identities = 881/881 (100%), Positives = 881/881 (100%)
Query: 43 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR 102
MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR
Sbjct: 1 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR 60
Query: 103 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE 162
QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE
Sbjct: 61 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE 120
Query: 163 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR 222
GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR
Sbjct: 121 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR 180
Query: 223 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS 282
KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS
Sbjct: 181 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS 240
Query: 283 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF 342
WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF
Sbjct: 241 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF 300
Query: 343 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE 402
NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE
Sbjct: 301 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE 360
Query: 403 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR 462
AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR
Sbjct: 361 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR 420
Query: 463 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN 522
QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN
Sbjct: 421 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN 480
Query: 523 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV 582
GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV
Sbjct: 481 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV 540
Query: 583 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI 642
REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI
Sbjct: 541 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI 600
Query: 643 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA 702
PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA
Sbjct: 601 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA 660
Query: 703 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS 762
NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS
Sbjct: 661 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS 720
Query: 763 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 822
NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM
Sbjct: 721 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 780
Query: 823 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI 882
TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI
Sbjct: 781 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI 840
Query: 883 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 923
STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
Sbjct: 841 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 881
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 1782 bits (4615), Expect = 0.0
Identities = 881/881 (100%), Positives = 881/881 (100%)
Query: 43 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR 102
MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR
Sbjct: 1 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR 60
Query: 103 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE 162
QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE
Sbjct: 61 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE 120
Query: 163 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR 222
GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR
Sbjct: 121 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR 180
Query: 223 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS 282
KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS
Sbjct: 181 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS 240
Query: 283 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF 342
WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF
Sbjct: 241 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF 300
Query: 343 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE 402
NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE
Sbjct: 301 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE 360
Query: 403 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR 462
AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR
Sbjct: 361 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR 420
Query: 463 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN 522
QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN
Sbjct: 421 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN 480
Query: 523 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV 582
GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV
Sbjct: 481 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV 540
Query: 583 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI 642
REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI
Sbjct: 541 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI 600
Query: 643 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA 702
PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA
Sbjct: 601 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA 660
Query: 703 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS 762
NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS
Sbjct: 661 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS 720
Query: 763 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 822
NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM
Sbjct: 721 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 780
Query: 823 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI 882
TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI
Sbjct: 781 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI 840
Query: 883 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 923
STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
Sbjct: 841 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 881
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 814 bits (2102), Expect = 0.0
Identities = 431/861 (50%), Positives = 593/861 (68%), Gaps = 43/861 (4%)
Query: 74 TPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGR 133
TPL L + ++ + +E++LRAG+ L +L+ P++IRDRKYHL+ YRQCC G
Sbjct: 36 TPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGT 95
Query: 134 ELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPE--P 191
ELVD ++ VHSR+Q VG+ QVLL++G L HV + FQD+ FYRF E E P
Sbjct: 96 ELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYL-FYRFLDDEHEDAP 154
Query: 192 VGTHE----MEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVA 247
+ T E +EEL + + LLSQ GPDA + + LRKPPGQRT ++L++I+EELLHIKA++
Sbjct: 155 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 214
Query: 248 HLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEG 307
HLS +VKRELA VL+FE H+K GTVLF+QG++GTSWYII KGSVNVV +GKG+V TLHEG
Sbjct: 215 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 274
Query: 308 DDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLE 367
DDFG+LALVNDAPRAA+I+LREDNCHFLRVDK+DFNRI++DVEA T+RL+EH + VLVLE
Sbjct: 275 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 334
Query: 368 RASQG-----AGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFL 422
+ G G S+P + +YTVMSGTPEKILE LE + +++ ++ T++ L+DF+
Sbjct: 335 KVPAGNRASNQGNSQP----QQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFI 390
Query: 423 LTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHT 482
+ H VFMP+ QLC AL+ H+H +P+ G+EQE+ Y N +++++RLV QW A+YG +L
Sbjct: 391 MMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQE 450
Query: 483 DPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPN 542
D V+ +FL++ V D R+ L+EQ PE + + + A PQ K + L
Sbjct: 451 DDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKA-PQKKHKVLLQQFNT 509
Query: 543 QDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLV 602
DE I+ D+V + + DH+ T+++PV SV+EV++A+A + G +G ++V
Sbjct: 510 GDERAQKRQ-PIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV 568
Query: 603 KVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVS 662
K++S G+ + L+P+ V T+L +N RLF ++ L P P+Q GPTVG+ +L+S
Sbjct: 569 KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMS 628
Query: 663 AKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATEL 722
+KDLA Q+T +DW LFN +H++ELI++ G +H TTANL+ F+RRFNE+Q+WV TE+
Sbjct: 629 SKDLAYQMTIYDWELFNCVHELELIYHTFG-RHNFKKTTANLDLFLRRFNEIQFWVVTEI 687
Query: 723 CLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRK 782
CLC R QLL+KFIK+AAH KE KNLNSFFA++ GLSN A+SRLA TWE+LP K +K
Sbjct: 688 CLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKK 747
Query: 783 LYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKM 842
Y+ E L+DPS NHR YRL +AKL PP+IPFMPLL+KDMTF HEGN T ++NL+NFEKM
Sbjct: 748 FYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKM 807
Query: 843 RMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYV 902
RM+A AR + + RS P +P ++ + H+D + +YV
Sbjct: 808 RMIANTARTVRYYRSQ---PFNPDAAQANKNHQDVR---------------------SYV 843
Query: 903 QQLKVIDNQRELSRLSRELEP 923
+QL VIDNQR LS++S LEP
Sbjct: 844 RQLNVIDNQRTLSQMSHRLEP 864
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a
[Homo sapiens]
Length = 1011
Score = 814 bits (2102), Expect = 0.0
Identities = 431/861 (50%), Positives = 593/861 (68%), Gaps = 43/861 (4%)
Query: 74 TPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGR 133
TPL L + ++ + +E++LRAG+ L +L+ P++IRDRKYHL+ YRQCC G
Sbjct: 180 TPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGT 239
Query: 134 ELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPE--P 191
ELVD ++ VHSR+Q VG+ QVLL++G L HV + FQD+ FYRF E E P
Sbjct: 240 ELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYL-FYRFLDDEHEDAP 298
Query: 192 VGTHE----MEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVA 247
+ T E +EEL + + LLSQ GPDA + + LRKPPGQRT ++L++I+EELLHIKA++
Sbjct: 299 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 358
Query: 248 HLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEG 307
HLS +VKRELA VL+FE H+K GTVLF+QG++GTSWYII KGSVNVV +GKG+V TLHEG
Sbjct: 359 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 418
Query: 308 DDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLE 367
DDFG+LALVNDAPRAA+I+LREDNCHFLRVDK+DFNRI++DVEA T+RL+EH + VLVLE
Sbjct: 419 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 478
Query: 368 RASQG-----AGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFL 422
+ G G S+P + +YTVMSGTPEKILE LE + +++ ++ T++ L+DF+
Sbjct: 479 KVPAGNRASNQGNSQP----QQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFI 534
Query: 423 LTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHT 482
+ H VFMP+ QLC AL+ H+H +P+ G+EQE+ Y N +++++RLV QW A+YG +L
Sbjct: 535 MMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQE 594
Query: 483 DPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPN 542
D V+ +FL++ V D R+ L+EQ PE + + + A PQ K + L
Sbjct: 595 DDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKA-PQKKHKVLLQQFNT 653
Query: 543 QDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLV 602
DE I+ D+V + + DH+ T+++PV SV+EV++A+A + G +G ++V
Sbjct: 654 GDERAQKRQ-PIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV 712
Query: 603 KVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVS 662
K++S G+ + L+P+ V T+L +N RLF ++ L P P+Q GPTVG+ +L+S
Sbjct: 713 KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMS 772
Query: 663 AKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATEL 722
+KDLA Q+T +DW LFN +H++ELI++ G +H TTANL+ F+RRFNE+Q+WV TE+
Sbjct: 773 SKDLAYQMTIYDWELFNCVHELELIYHTFG-RHNFKKTTANLDLFLRRFNEIQFWVVTEI 831
Query: 723 CLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRK 782
CLC R QLL+KFIK+AAH KE KNLNSFFA++ GLSN A+SRLA TWE+LP K +K
Sbjct: 832 CLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKK 891
Query: 783 LYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKM 842
Y+ E L+DPS NHR YRL +AKL PP+IPFMPLL+KDMTF HEGN T ++NL+NFEKM
Sbjct: 892 FYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKM 951
Query: 843 RMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYV 902
RM+A AR + + RS P +P ++ + H+D + +YV
Sbjct: 952 RMIANTARTVRYYRSQ---PFNPDAAQANKNHQDVR---------------------SYV 987
Query: 903 QQLKVIDNQRELSRLSRELEP 923
+QL VIDNQR LS++S LEP
Sbjct: 988 RQLNVIDNQRTLSQMSHRLEP 1008
Score = 67.0 bits (162), Expect = 8e-11
Identities = 43/131 (32%), Positives = 74/131 (56%), Gaps = 9/131 (6%)
Query: 221 LRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKG 280
L K P +R+ E++D+IF L +KA ++ ++ +E K G LF QGD G
Sbjct: 19 LDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEK-GITLFRQGDIG 77
Query: 281 TSWYIIWKGSVNV-----VTHGKGL-VTTLHEGDDFGQLALVNDAPRAATIILREDNCHF 334
T+WY + GS++V +H + + TL G FG+ +++++ PR ATI+ RE +
Sbjct: 78 TNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESS-EL 135
Query: 335 LRVDKQDFNRI 345
LR++++DF +
Sbjct: 136 LRIEQKDFKAL 146
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 379 bits (973), Expect = e-105
Identities = 269/781 (34%), Positives = 415/781 (53%), Gaps = 65/781 (8%)
Query: 153 VGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTH-EMEEELAEAVALLSQR 211
+G+ Q+LLD G + V FQD FY+F E + E EEE V LL Q
Sbjct: 3 IGVWQLLLDMGIMLSVDQHLYFQDTYV-FYQFSSDECSYLYCEFEREEEWQNGVKLLLQL 61
Query: 212 GPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGT 271
P + + Q+ ++ + E L+ L+++V+RELAAV+ + A
Sbjct: 62 VPLIPARGGICELSHQKIEDSEESSDEILVR------LTSAVQRELAAVIALKARKSA-- 113
Query: 272 VLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDN 331
Q ++ ++ + +V G++ L E D+ G++ LV L ++N
Sbjct: 114 --IEQDEENNDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQK--------LAKEN 163
Query: 332 CHFLRVDKQDFNRII-KDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRN----RY 386
FL+ DK++ + +D E T++++E + VLVL++ Q GP+ PT G RY
Sbjct: 164 YQFLQTDKKEQEKSEHQDDEVTTVQVKEQDQSVLVLKKV-QCCGPA--PTAGSAESHWRY 220
Query: 387 TVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEP 446
V+SGTPEKILE LL + + TET L DFLLT+ VFM + LC ALL H+ +
Sbjct: 221 VVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKK 280
Query: 447 AGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNL 506
G E+ V +++++L LVSQW+ALY L D + FL+ + V D +
Sbjct: 281 YQGKEENSD--VPRRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPI 338
Query: 507 LREQWPERRRC---HRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYD 563
L ++ E ++ HR + SPQ K + L ++ L + +++
Sbjct: 339 LEKELKEFQKILGMHR-RHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTET-EEIFCH 396
Query: 564 ICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV-LVKVNSAGDAIGLQPDARGVAT 622
+ +HS ++++ V++ +E++ +A++ + + + LV + +G+ LQP+ ++
Sbjct: 397 VYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISK 456
Query: 623 SLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIH 682
SL + R++V L P + S L + + DLA +L + DWSLFNSIH
Sbjct: 457 SLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGM-NTWDLALELMNFDWSLFNSIH 515
Query: 683 QVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLA 742
+ ELI++ Q + TANL ++R NE+Q WVATE+ LC G R QL++KFIK+A
Sbjct: 516 EQELIYFTFSRQGSGE-HTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIA 574
Query: 743 AHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRL 802
AH K Q+NLNSFFA++ GL+ +++SRL+ TWE++P K +KL+S LE L DPS NH+ YR
Sbjct: 575 AHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRD 634
Query: 803 ALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVP 862
A K+ PP IPFMPLLLKD+TFIHEGN T ++NL+NFEK+ M+A R L HCR++
Sbjct: 635 AFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGD 694
Query: 863 LSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELE 922
LSP H++ + +YV L VID+Q+ L LS +E
Sbjct: 695 LSPKE------HQELK---------------------SYVNHLYVIDSQQALFELSHRIE 727
Query: 923 P 923
P
Sbjct: 728 P 728
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 262 bits (669), Expect = 1e-69
Identities = 166/475 (34%), Positives = 259/475 (54%), Gaps = 44/475 (9%)
Query: 461 KRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRL 520
++Q L ++ ++ Y +L + A ++ L L+ +D L LRE + R H+L
Sbjct: 9 RKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLRE---DTLRLHQL 65
Query: 521 ENGCG------NASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTL 574
N P + + L D L + A + D++ + PDHS +T+
Sbjct: 66 VETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQ-TRVAFRGSDEIFCRVYMPDHSYVTI 124
Query: 575 QLPVTASVREVMAALAQE-------DGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLN 627
+ ++ASV++++ ++ ++ G +LV V+S+G+ + LQP V T+LG+N
Sbjct: 125 RSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGIN 184
Query: 628 ERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELI 687
LF L+P P+++ + G E + V +D+A LT W LF +H++E +
Sbjct: 185 SHLFACTRDSYEALVPLPEEIQVSPGDTE-IHRVEPEDVANHLTAFHWELFRCVHELEFV 243
Query: 688 HYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKE 747
YV + R TANLE ++R +E+ +WVATE+ LC PG RAQLL+KFIK+AA K+
Sbjct: 244 DYVFHGERGRR-ETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQ 302
Query: 748 QKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKL 807
++L SF+AV+ GL N+A+SRL TWE+LP K + L+ E L DP NH+ YR ++K+
Sbjct: 303 NQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKM 362
Query: 808 SPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLR 867
PPVIPF+PL+LKD+TF+HEG+ TLV+ L+N EK+ +A R + RS P+ L +
Sbjct: 363 KPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSR-PLCLD-ME 420
Query: 868 SRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELE 922
+ +HL T AYV+Q +VIDNQ L LS +LE
Sbjct: 421 ASPNHLQ-----------------------TKAYVRQFQVIDNQNLLFELSYKLE 452
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 155 bits (392), Expect = 2e-37
Identities = 103/295 (34%), Positives = 156/295 (52%), Gaps = 7/295 (2%)
Query: 578 VTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQE 637
V ++RE A A D ++ +V V L +A + L+ R ++ N E
Sbjct: 634 VIQAIRE-FAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNME 692
Query: 638 VHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR 697
L D S L +S ++A QL+ ++ LF +I E I + LR
Sbjct: 693 TETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF---KLR 749
Query: 698 DVTT-ANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFA 756
T+ ANL+RF N+ +WVA+E+ R ++++ FIK+A H +E KN NS FA
Sbjct: 750 SKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFA 809
Query: 757 VMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL--AKLSPPVIPF 814
++ GL+ + ++RL TWE+LP+K KL+ L+ L DPS N YR L L PP+IP
Sbjct: 810 IISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPL 869
Query: 815 MPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSR 869
P++ KD+TF+HEGN + V+ L+NFEK+RM+A+ R + S N P R+R
Sbjct: 870 FPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTR 924
Score = 126 bits (317), Expect = 8e-29
Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 43/351 (12%)
Query: 198 EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKREL 257
EE++ A L R ++ L K P RTD++++ + E + + A A+++ SV+REL
Sbjct: 91 EEDIERASDPLMSRD---IVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRREL 147
Query: 258 AAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVN 317
AV++F +AGT++ + G++ SW +I GSV VT+ G L G+ FG ++
Sbjct: 148 CAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVE-VTYPDGKAEILCMGNSFGVSPTMD 206
Query: 318 DAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSR 377
+ + D+C F+ + +QD+ RI+ VE ++EE G++V+V E
Sbjct: 207 KEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDR---- 262
Query: 378 PPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAA 437
T R + V+ GT E++ L+E + S DP TF+ DFLLT+R F+ S
Sbjct: 263 --TGTRKGHIVIKGTSERLTMHLVE----EHSVVDP--TFIEDFLLTYRTFLSSPMEVGK 314
Query: 438 LLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLV 497
L + +P + R ++ R+V WV + + DP T FL++
Sbjct: 315 KLLEWFNDP-------------SLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE--- 358
Query: 498 GRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLP 548
+NL RE+ R L C + + K R + + P+++ PLP
Sbjct: 359 ------NNLEREKMGGHLRL--LNIAC---AAKAKRRLMTLTKPSREAPLP 398
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 146 bits (369), Expect = 8e-35
Identities = 89/253 (35%), Positives = 137/253 (54%), Gaps = 6/253 (2%)
Query: 620 VATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFN 679
+A + LN R ++ N E L D S + +S ++A QL+ D+ LF
Sbjct: 818 LADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFR 877
Query: 680 SIHQVELIHYVLGPQHLRDVT-TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKF 738
+I E I + L T +L+RF N+ +WVA+E+ R ++++ F
Sbjct: 878 NIEPTEYIDDLF---KLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHF 934
Query: 739 IKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHR 798
IK+A H +E KN NS FA++ GL+ ++++RL TWE+LP K K L+ + DPS N
Sbjct: 935 IKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMA 994
Query: 799 VYR--LALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCR 856
YR L+ + PP+IP P++ KDMTF+HEGN + V+ L+NFEK+RM+++ R +
Sbjct: 995 KYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMT 1054
Query: 857 SHNPVPLSPLRSR 869
S N P R R
Sbjct: 1055 SANMDPAMMFRQR 1067
Score = 134 bits (337), Expect = 4e-31
Identities = 100/356 (28%), Positives = 174/356 (48%), Gaps = 35/356 (9%)
Query: 156 CQVLLDEGA--LCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGP 213
C + D G+ L + + D R P PV + + EEE E +G
Sbjct: 193 CSIASDSGSSSLSDIYQATESEVGDVDLTRLP---EGPVDSEDDEEEDEEIDRTDPLQGR 249
Query: 214 DALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVL 273
D L+ L K P +TD++++ + E + + A A+++ SV+REL +V++FE +AG ++
Sbjct: 250 D-LVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAII 308
Query: 274 FSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCH 333
G + SWY+I G+V ++H G V L G+ FG ++ + + D+C
Sbjct: 309 LEDGQELDSWYVILNGTVE-ISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQ 367
Query: 334 FLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTP 393
F+ + +QD+ RI+ VE T ++EE G++V+V E + R + V+ TP
Sbjct: 368 FVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGT------RKGHIVIKATP 421
Query: 394 EKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPS-AQLCAALLHHFHVEPAGGSEQ 452
E+++ L+E + S DP T++ DFLLT+R F+ S + LL F ++
Sbjct: 422 ERLIMHLIE----EHSIVDP--TYIEDFLLTYRTFLESPLDVGIKLLEWFKID------- 468
Query: 453 ERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLR 508
+ R ++ R+V WV + + DP T FL++ + DT+++ LR
Sbjct: 469 -------SLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNL-EDTKMNGHLR 516
Score = 41.2 bits (95), Expect = 0.004
Identities = 29/92 (31%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 220 ALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDK 279
ALRK P +RT E+L+ I+ L ++ +++L R ++A +E +S VLF
Sbjct: 12 ALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYS-GNQVLFCSETI 70
Query: 280 GTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFG 311
WYI+ GS V+ G ++ G FG
Sbjct: 71 ARCWYILLSGS--VLVKGSMVLPPCSFGKQFG 100
>gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchange
factor 2, partial [Homo sapiens]
Length = 803
Score = 126 bits (317), Expect = 8e-29
Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 43/351 (12%)
Query: 198 EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKREL 257
EE++ A L R ++ L K P RTD++++ + E + + A A+++ SV+REL
Sbjct: 91 EEDIERASDPLMSRD---IVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRREL 147
Query: 258 AAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVN 317
AV++F +AGT++ + G++ SW +I GSV VT+ G L G+ FG ++
Sbjct: 148 CAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVE-VTYPDGKAEILCMGNSFGVSPTMD 206
Query: 318 DAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSR 377
+ + D+C F+ + +QD+ RI+ VE ++EE G++V+V E
Sbjct: 207 KEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDR---- 262
Query: 378 PPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAA 437
T R + V+ GT E++ L+E + S DP TF+ DFLLT+R F+ S
Sbjct: 263 --TGTRKGHIVIKGTSERLTMHLVE----EHSVVDP--TFIEDFLLTYRTFLSSPMEVGK 314
Query: 438 LLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLV 497
L + +P + R ++ R+V WV + + DP T FL++
Sbjct: 315 KLLEWFNDP-------------SLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE--- 358
Query: 498 GRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLP 548
+NL RE+ R L C + + K R + + P+++ PLP
Sbjct: 359 ------NNLEREKMGGHLRL--LNIAC---AAKAKRRLMTLTKPSREAPLP 398
Score = 52.8 bits (125), Expect = 1e-06
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 5/174 (2%)
Query: 578 VTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQE 637
V ++RE A A D ++ +V V L +A + L+ R ++ N E
Sbjct: 634 VIQAIRE-FAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNME 692
Query: 638 VHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR 697
L D S L +S ++A QL+ ++ LF +I E I + LR
Sbjct: 693 TETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF---KLR 749
Query: 698 DVTT-ANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKN 750
T+ ANL+RF N+ +WVA+E+ R ++++ FIK+A H +E KN
Sbjct: 750 SKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKN 803
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 107 bits (267), Expect = 5e-23
Identities = 60/177 (33%), Positives = 100/177 (56%), Gaps = 8/177 (4%)
Query: 665 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 724
++A QLT D LF +++E+ +L + + + NL +F FN + YWV + + L
Sbjct: 861 EIAEQLTLLDAELF---YKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIML 917
Query: 725 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 784
R +LL KFIK+ HL++ N NS+ A++ L ++ I RL W++ + Y
Sbjct: 918 QEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EWQKQTSEGLAEY 975
Query: 785 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEK 841
L+D S + R YR AL+++ PP IP++ L+L+D+TF+H GN ++ +NF K
Sbjct: 976 CT---LIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1029
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 107 bits (267), Expect = 5e-23
Identities = 60/177 (33%), Positives = 100/177 (56%), Gaps = 8/177 (4%)
Query: 665 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 724
++A QLT D LF +++E+ +L + + + NL +F FN + YWV + + L
Sbjct: 843 EIAEQLTLLDAELF---YKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIML 899
Query: 725 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 784
R +LL KFIK+ HL++ N NS+ A++ L ++ I RL W++ + Y
Sbjct: 900 QEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EWQKQTSEGLAEY 957
Query: 785 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEK 841
L+D S + R YR AL+++ PP IP++ L+L+D+TF+H GN ++ +NF K
Sbjct: 958 CT---LIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1011
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 86.7 bits (213), Expect = 9e-17
Identities = 58/159 (36%), Positives = 84/159 (52%), Gaps = 15/159 (9%)
Query: 701 TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFG 760
T NLE ++ FN L Y VATE+C+ RA+++ FI +A N NS A++ G
Sbjct: 252 TRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISG 311
Query: 761 LSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSP 809
++ S +SRL TW ++ K K + LE +DPS N YR AL +
Sbjct: 312 MNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREK 368
Query: 810 PVIPFMPLLLKDMTFIHEG-NHTLVENLINFEKMRMMAR 847
VIPF LL+KD+ F++EG + L +NFEK +A+
Sbjct: 369 IVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAK 407
Score = 30.8 bits (68), Expect = 6.1
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 397 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERST 456
LE L++ + P+ + P T++ FLL+ R+FM +L A + H VE S+ +
Sbjct: 43 LEALIQHLVPNVDYY-PDRTYIFTFLLSSRLFMHPYELMAKVC-HLCVEHQRLSDPDSDK 100
Query: 457 YVCNK-RQQILRLVSQWVALY 476
K +IL+L+++W +
Sbjct: 101 NQMRKIAPKILQLLTEWTETF 121
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 86.7 bits (213), Expect = 9e-17
Identities = 57/159 (35%), Positives = 86/159 (54%), Gaps = 15/159 (9%)
Query: 701 TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFG 760
T+NLE +++ FN L Y VATE+C+ RAQ++ FI +A N NS A++ G
Sbjct: 245 TSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISG 304
Query: 761 LSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSP 809
++ S +SRL TW ++ + K + LE +DP+ N YR AL +
Sbjct: 305 MNMSPVSRLKKTWAKV--RTAKFF-ILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREK 361
Query: 810 PVIPFMPLLLKDMTFIHEG-NHTLVENLINFEKMRMMAR 847
VIPF LL+KD+ F++EG + L +NFEK +A+
Sbjct: 362 IVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAK 400
Score = 32.7 bits (73), Expect = 1.6
Identities = 33/133 (24%), Positives = 62/133 (46%), Gaps = 19/133 (14%)
Query: 375 PSRPPTPGRNR-YTVMSGTPEKI-LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSA 432
P PT G ++ G P LE L++ + P + + P + ++ FLL+ R+F+
Sbjct: 19 PPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYY-PEKAYIFTFLLSSRLFIEPR 77
Query: 433 QLCAALLHHFHVEPAGGSEQERSTYVCNKRQ------QILRLVSQWVALYGSMLHTDPVA 486
+L A + H +E +Q+ V +K + ++L+L+++W + D
Sbjct: 78 ELLARVC-HLCIE-----QQQLDKPVLDKARVRKFGPKLLQLLAEWTETF----PRDFQE 127
Query: 487 TSFLQKLSDLVGR 499
S + L D+VGR
Sbjct: 128 ESTIGHLKDVVGR 140
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 83.6 bits (205), Expect = 8e-16
Identities = 56/193 (29%), Positives = 95/193 (49%), Gaps = 2/193 (1%)
Query: 661 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT 720
V+ ++ AGQ+T D +F +I EL + + + N F RRFN + +WV
Sbjct: 48 VTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKE-KYSSAPNAVAFTRRFNHVSFWVVR 106
Query: 721 ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV 780
E+ RA++L +IK A L E NL++ AV+ GL ++ I RL TW L K
Sbjct: 107 EILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKD 166
Query: 781 RKLYSALERLLDPSWNHRVYRLALAKLS-PPVIPFMPLLLKDMTFIHEGNHTLVENLINF 839
+ + LE ++ N++ R ++ L P IP++ + L D+T+I + L N
Sbjct: 167 KTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENE 226
Query: 840 EKMRMMARAARML 852
++ +M R++
Sbjct: 227 QRSNLMNNILRII 239
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 82.8 bits (203), Expect = 1e-15
Identities = 69/241 (28%), Positives = 108/241 (44%), Gaps = 12/241 (4%)
Query: 665 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 724
+LA LT + F I + YV+ H LER + FN + WV +
Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVI---HGCLENNPTLERSIALFNGISKWVQLMVLS 211
Query: 725 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 784
P P RA+++ KFI +A L + KN N+ AV+ GLS+S+ISRL T L +V K +
Sbjct: 212 KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNW 271
Query: 785 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHE-GNHTLVENLINFEKMR 843
+ + L+ + N+ YR A A IP + + LKD+ +H EN +N KM
Sbjct: 272 NEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMH 331
Query: 844 MMARAARML-------HHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPA 896
++ L HH + + ++ L + H + + ++S E S P
Sbjct: 332 QLSVTLSELVSLQNASHHLEPNMDL-INLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPT 390
Query: 897 S 897
S
Sbjct: 391 S 391
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 82.8 bits (203), Expect = 1e-15
Identities = 69/241 (28%), Positives = 108/241 (44%), Gaps = 12/241 (4%)
Query: 665 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 724
+LA LT + F I + YV+ H LER + FN + WV +
Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVI---HGCLENNPTLERSIALFNGISKWVQLMVLS 211
Query: 725 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 784
P P RA+++ KFI +A L + KN N+ AV+ GLS+S+ISRL T L +V K +
Sbjct: 212 KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNW 271
Query: 785 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHE-GNHTLVENLINFEKMR 843
+ + L+ + N+ YR A A IP + + LKD+ +H EN +N KM
Sbjct: 272 NEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMH 331
Query: 844 MMARAARML-------HHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPA 896
++ L HH + + ++ L + H + + ++S E S P
Sbjct: 332 QLSVTLSELVSLQNASHHLEPNMDL-INLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPT 390
Query: 897 S 897
S
Sbjct: 391 S 391
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 82.8 bits (203), Expect = 1e-15
Identities = 56/198 (28%), Positives = 96/198 (48%), Gaps = 4/198 (2%)
Query: 655 AEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL-RDVTTANLERFMRRFNE 713
AE + +SA +LA Q+T D +F SI E + G L ++ T + + + FN+
Sbjct: 995 AECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQ--GWMKLDKNERTPYIMKTSQHFND 1052
Query: 714 LQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTW 773
+ VA+++ RA + K++ +A + N N + L+ SAI RL TW
Sbjct: 1053 MSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTW 1112
Query: 774 ERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLV 833
++ + + L L++ + + R L +PP +P++ + L D+ FI EG
Sbjct: 1113 AKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFT 1172
Query: 834 -ENLINFEKMRMMARAAR 850
E L+NF KMRM++ R
Sbjct: 1173 EEGLVNFSKMRMISHIIR 1190
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 81.6 bits (200), Expect = 3e-15
Identities = 69/241 (28%), Positives = 111/241 (46%), Gaps = 13/241 (5%)
Query: 665 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 724
+LA LT + F I + YV+ H LER + FN + WV +
Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVI---HGCLENNPTLERSIALFNGISKWVQLMVLS 211
Query: 725 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 784
P P RA+++ KFI +A L + KN N+ AV+ GLS+S+ISRL T L +V K +
Sbjct: 212 KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNW 271
Query: 785 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHE-GNHTLVENLINFEKMR 843
+ + L+ + N+ YR A A IP + + LKD+ +H EN +N KM
Sbjct: 272 NEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMH 331
Query: 844 MMARAARML-------HHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPA 896
++ L HH + + ++ L + H + + ++S E +++SP
Sbjct: 332 QLSVTLSELVSLQNASHHLEPNMDL-INLLTLSLDLYHTEDDIYKLSLVLEPR-NSKSPT 389
Query: 897 S 897
S
Sbjct: 390 S 390
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 79.3 bits (194), Expect = 1e-14
Identities = 55/198 (27%), Positives = 96/198 (48%), Gaps = 4/198 (2%)
Query: 655 AEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL-RDVTTANLERFMRRFNE 713
AE + SA ++A QLT D +F I E + G L ++ T + + + FN+
Sbjct: 1015 AEPFENHSALEIAEQLTLLDHLVFKKIPYEEF--FGQGWMKLEKNERTPYIMKTTKHFND 1072
Query: 714 LQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTW 773
+ +A+E+ R + K++ +A + N N+ + ++ SAI RL TW
Sbjct: 1073 ISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTW 1132
Query: 774 ERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLV 833
++ + + L L++L+ + R AL PP +P++ + L D+ FI EG
Sbjct: 1133 LKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYT 1192
Query: 834 EN-LINFEKMRMMARAAR 850
E+ L+NF KMRM++ R
Sbjct: 1193 EDGLVNFSKMRMISHIIR 1210
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 79.3 bits (194), Expect = 1e-14
Identities = 55/198 (27%), Positives = 96/198 (48%), Gaps = 4/198 (2%)
Query: 655 AEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL-RDVTTANLERFMRRFNE 713
AE + SA ++A QLT D +F I E + G L ++ T + + + FN+
Sbjct: 1031 AEPFENHSALEIAEQLTLLDHLVFKKIPYEEF--FGQGWMKLEKNERTPYIMKTTKHFND 1088
Query: 714 LQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTW 773
+ +A+E+ R + K++ +A + N N+ + ++ SAI RL TW
Sbjct: 1089 ISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTW 1148
Query: 774 ERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLV 833
++ + + L L++L+ + R AL PP +P++ + L D+ FI EG
Sbjct: 1149 LKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYT 1208
Query: 834 EN-LINFEKMRMMARAAR 850
E+ L+NF KMRM++ R
Sbjct: 1209 EDGLVNFSKMRMISHIIR 1226
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 79.3 bits (194), Expect = 1e-14
Identities = 55/198 (27%), Positives = 96/198 (48%), Gaps = 4/198 (2%)
Query: 655 AEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL-RDVTTANLERFMRRFNE 713
AE + SA ++A QLT D +F I E + G L ++ T + + + FN+
Sbjct: 247 AEPFENHSALEIAEQLTLLDHLVFKKIPYEEF--FGQGWMKLEKNERTPYIMKTTKHFND 304
Query: 714 LQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTW 773
+ +A+E+ R + K++ +A + N N+ + ++ SAI RL TW
Sbjct: 305 ISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTW 364
Query: 774 ERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLV 833
++ + + L L++L+ + R AL PP +P++ + L D+ FI EG
Sbjct: 365 LKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYT 424
Query: 834 EN-LINFEKMRMMARAAR 850
E+ L+NF KMRM++ R
Sbjct: 425 EDGLVNFSKMRMISHIIR 442
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 78.6 bits (192), Expect = 3e-14
Identities = 53/185 (28%), Positives = 95/185 (51%), Gaps = 4/185 (2%)
Query: 659 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWV 718
D + ++L+ LT ++ F I + +Y++ + T +ER + N + WV
Sbjct: 202 DHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPT---MERSIALCNGISQWV 258
Query: 719 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 778
+ P P RA++ KFI++A L + +N N+ AV+ GL +S+ISRL T +PH
Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 779 KVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVEN-LI 837
++ K+ + LL S N+ YR A + + IP + + LKD+ ++E +E+ +
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
Query: 838 NFEKM 842
N K+
Sbjct: 379 NVHKL 383
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 78.6 bits (192), Expect = 3e-14
Identities = 53/185 (28%), Positives = 95/185 (51%), Gaps = 4/185 (2%)
Query: 659 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWV 718
D + ++L+ LT ++ F I + +Y++ + T +ER + N + WV
Sbjct: 202 DHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPT---MERSIALCNGISQWV 258
Query: 719 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 778
+ P P RA++ KFI++A L + +N N+ AV+ GL +S+ISRL T +PH
Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 779 KVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVEN-LI 837
++ K+ + LL S N+ YR A + + IP + + LKD+ ++E +E+ +
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
Query: 838 NFEKM 842
N K+
Sbjct: 379 NVHKL 383
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 78.2 bits (191), Expect = 3e-14
Identities = 53/191 (27%), Positives = 94/191 (49%), Gaps = 5/191 (2%)
Query: 661 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT 720
V+ ++ A Q+T D +F +I EL + + N+ F RRFN++ +WV
Sbjct: 49 VTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAP-NVVAFTRRFNQVSFWVVR 107
Query: 721 ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV 780
E+ RA++L F+K+A L E NL+S +V+ L ++ I RL TW L K
Sbjct: 108 EILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKD 167
Query: 781 RKLYSALERLLDPSWNHRVYRLALAKLS-PPVIPFMPLLLKDMTFI---HEGNHTLVENL 836
+ + L+ L+ N++ R + L P IP++ + L D+ +I + + +++EN
Sbjct: 168 KTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENE 227
Query: 837 INFEKMRMMAR 847
+M + R
Sbjct: 228 QRSNQMNNILR 238
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 72.4 bits (176), Expect = 2e-12
Identities = 51/202 (25%), Positives = 99/202 (49%), Gaps = 13/202 (6%)
Query: 653 GSAEGLDLVSAK--DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRR 710
G E DL++ ++A QLT + L+ ++ EL+ V + +++ + NL + +R
Sbjct: 769 GHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKED-KEINSPNLLKMIRH 827
Query: 711 FNELQYWVATELCLCPVPG--PRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISR 768
L W E C+ R ++ + I++ +E N N V+ +++S + R
Sbjct: 828 TTNLTLWF--EKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYR 885
Query: 769 LAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEG 828
L HT+E++P + +K+ L + +++ Y L ++PP +PF + L ++ EG
Sbjct: 886 LDHTFEQIPSRQKKILEEAHELSED--HYKKYLAKLRSINPPCVPFFGIYLTNILKTEEG 943
Query: 829 NHTLV----ENLINFEKMRMMA 846
N ++ + LINF K R +A
Sbjct: 944 NPEVLKRHGKELINFSKRRKVA 965
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 70.5 bits (171), Expect = 7e-12
Identities = 66/202 (32%), Positives = 96/202 (47%), Gaps = 24/202 (11%)
Query: 666 LAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR------DVT-TANLERFMRRFNELQYWV 718
LA QLT + +SI+ +L+ V L D+T T +LE + FN L V
Sbjct: 218 LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277
Query: 719 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 778
ATE+C R ++L FI +A N NS A++ G++ S ++RL TW ++
Sbjct: 278 ATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV-- 335
Query: 779 KVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSPPVIPFMPLLLKDMTFIHE 827
K K + LE +DPS N YR AL + VIP L +KD+ F+H+
Sbjct: 336 KTAK-FDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHK 394
Query: 828 --GNHTLVENLINFEKMRMMAR 847
NH L INF+K ++R
Sbjct: 395 IHTNH-LPNGHINFKKFWEISR 415
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 70.1 bits (170), Expect = 9e-12
Identities = 52/203 (25%), Positives = 101/203 (49%), Gaps = 15/203 (7%)
Query: 653 GSAEGLDLVSAK--DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRR 710
G E DL++ ++A QLT + L+ + EL+ V + +++ + NL + +R
Sbjct: 767 GQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKED-KEINSPNLLKMIRH 825
Query: 711 FNELQYWVATELCLCPVPG--PRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISR 768
L W E C+ R +L + I++ ++ N N ++ +++ ++ R
Sbjct: 826 TTNLTLWF--EKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYR 883
Query: 769 LAHTWERLPHKVRKLYSALERLLDPSWNH-RVYRLALAKLSPPVIPFMPLLLKDMTFIHE 827
L HT+E L + RK+ L+ ++ S +H + Y + L ++PP +PF + L ++ E
Sbjct: 884 LDHTFEALQERKRKI---LDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEE 940
Query: 828 GNHTLV----ENLINFEKMRMMA 846
GN+ + ++LINF K R +A
Sbjct: 941 GNNDFLKKKGKDLINFSKRRKVA 963
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 67.0 bits (162), Expect = 8e-11
Identities = 50/164 (30%), Positives = 78/164 (47%), Gaps = 3/164 (1%)
Query: 659 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWV 718
D + +LA LT ++ F I + +V H V LERF+ FN + WV
Sbjct: 151 DHLEPMELAEHLTYLEYRSFCKILFQDYHSFVT---HGCTVDNPVLERFISLFNSVSQWV 207
Query: 719 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 778
+ P RA ++ F+ +A L + +N N+ AV+ GLS+S+ISRL T +
Sbjct: 208 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267
Query: 779 KVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 822
+ KL+ L L+ + N+ YR LA P + + LKD+
Sbjct: 268 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDL 311
Score = 38.5 bits (88), Expect = 0.029
Identities = 26/109 (23%), Positives = 50/109 (45%), Gaps = 10/109 (9%)
Query: 392 TPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSE 451
T E++L +EA DP + FL+ H ++PS+QL A LLH + +
Sbjct: 12 TVEELLRGCIEAFDDSGKVRDPQ--LVRMFLMMHPWYIPSSQLAAKLLHIY--------Q 61
Query: 452 QERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRD 500
Q R + + + LV W++ + + +P +++L L+ ++
Sbjct: 62 QSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQE 110
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 67.0 bits (162), Expect = 8e-11
Identities = 50/164 (30%), Positives = 78/164 (47%), Gaps = 3/164 (1%)
Query: 659 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWV 718
D + +LA LT ++ F I + +V H V LERF+ FN + WV
Sbjct: 151 DHLEPMELAEHLTYLEYRSFCKILFQDYHSFVT---HGCTVDNPVLERFISLFNSVSQWV 207
Query: 719 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 778
+ P RA ++ F+ +A L + +N N+ AV+ GLS+S+ISRL T +
Sbjct: 208 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267
Query: 779 KVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 822
+ KL+ L L+ + N+ YR LA P + + LKD+
Sbjct: 268 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDL 311
Score = 38.5 bits (88), Expect = 0.029
Identities = 26/109 (23%), Positives = 50/109 (45%), Gaps = 10/109 (9%)
Query: 392 TPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSE 451
T E++L +EA DP + FL+ H ++PS+QL A LLH + +
Sbjct: 12 TVEELLRGCIEAFDDSGKVRDPQ--LVRMFLMMHPWYIPSSQLAAKLLHIY--------Q 61
Query: 452 QERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRD 500
Q R + + + LV W++ + + +P +++L L+ ++
Sbjct: 62 QSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQE 110
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,414,371
Number of Sequences: 37866
Number of extensions: 1835796
Number of successful extensions: 4932
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 4740
Number of HSP's gapped (non-prelim): 166
length of query: 923
length of database: 18,247,518
effective HSP length: 112
effective length of query: 811
effective length of database: 14,006,526
effective search space: 11359292586
effective search space used: 11359292586
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.