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Search of human proteins with 148612825
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148612825 Rap GTPase interactor [Homo sapiens]
(1075 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148612825 Rap GTPase interactor [Homo sapiens] 2165 0.0
gi|38570105 Ras-interacting protein 1 [Homo sapiens] 481 e-135
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora... 75 3e-13
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora... 75 3e-13
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 71 5e-12
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 71 5e-12
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 71 5e-12
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 71 5e-12
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 71 5e-12
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 70 1e-11
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 67 7e-11
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 67 7e-11
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 67 7e-11
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 65 3e-10
gi|148746189 multiple PDZ domain protein [Homo sapiens] 64 8e-10
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 63 2e-09
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 63 2e-09
gi|112382257 InaD-like [Homo sapiens] 62 4e-09
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 60 1e-08
gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens] 60 1e-08
gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens] 60 1e-08
gi|157388993 synaptojanin 2 binding protein [Homo sapiens] 59 2e-08
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 59 2e-08
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 59 2e-08
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 59 2e-08
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora... 59 2e-08
gi|215982794 myosin VA isoform 2 [Homo sapiens] 59 2e-08
gi|215982791 myosin VA isoform 1 [Homo sapiens] 59 2e-08
gi|140972063 protein phosphatase 1, regulatory subunit 9B [Homo ... 58 5e-08
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 57 7e-08
>gi|148612825 Rap GTPase interactor [Homo sapiens]
Length = 1075
Score = 2165 bits (5611), Expect = 0.0
Identities = 1075/1075 (100%), Positives = 1075/1075 (100%)
Query: 1 MFYGTHFIMSPPTKSKLKRQSQLLSSMLSRTLSYKYRDLDSTFSSLGASDDPAELSTQLS 60
MFYGTHFIMSPPTKSKLKRQSQLLSSMLSRTLSYKYRDLDSTFSSLGASDDPAELSTQLS
Sbjct: 1 MFYGTHFIMSPPTKSKLKRQSQLLSSMLSRTLSYKYRDLDSTFSSLGASDDPAELSTQLS 60
Query: 61 APGVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAG 120
APGVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAG
Sbjct: 61 APGVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAG 120
Query: 121 DAGQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKRSDVEELAAKEVDTITAGI 180
DAGQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKRSDVEELAAKEVDTITAGI
Sbjct: 121 DAGQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKRSDVEELAAKEVDTITAGI 180
Query: 181 NAQARRLQRSRAKGTPTPALGDARSSPPPRLRRTVSETSLSPVNALPAAAQGPEEPGPDA 240
NAQARRLQRSRAKGTPTPALGDARSSPPPRLRRTVSETSLSPVNALPAAAQGPEEPGPDA
Sbjct: 181 NAQARRLQRSRAKGTPTPALGDARSSPPPRLRRTVSETSLSPVNALPAAAQGPEEPGPDA 240
Query: 241 MRYSLYQSPHLLLLQGYSQQHDSLVYVLNRDRHTVGQRTPSSKPSISLSAPDILPLHCTI 300
MRYSLYQSPHLLLLQGYSQQHDSLVYVLNRDRHTVGQRTPSSKPSISLSAPDILPLHCTI
Sbjct: 241 MRYSLYQSPHLLLLQGYSQQHDSLVYVLNRDRHTVGQRTPSSKPSISLSAPDILPLHCTI 300
Query: 301 RRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQ 360
RRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQ
Sbjct: 301 RRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQ 360
Query: 361 AQPLPARALARLRAVPQSCRLCGAALGARGAASPTQAALPRRQQLLLEFEPHLEDTLLQR 420
AQPLPARALARLRAVPQSCRLCGAALGARGAASPTQAALPRRQQLLLEFEPHLEDTLLQR
Sbjct: 361 AQPLPARALARLRAVPQSCRLCGAALGARGAASPTQAALPRRQQLLLEFEPHLEDTLLQR 420
Query: 421 IMTLIEPGGDDHKLTPAFLLCLCIQHSATHFQPGTFGQLLLKIARLIRETVWEKTKELAE 480
IMTLIEPGGDDHKLTPAFLLCLCIQHSATHFQPGTFGQLLLKIARLIRETVWEKTKELAE
Sbjct: 421 IMTLIEPGGDDHKLTPAFLLCLCIQHSATHFQPGTFGQLLLKIARLIRETVWEKTKELAE 480
Query: 481 KQAQLQEPISLASCAMADLVPDLQPILFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGS 540
KQAQLQEPISLASCAMADLVPDLQPILFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGS
Sbjct: 481 KQAQLQEPISLASCAMADLVPDLQPILFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGS 540
Query: 541 KESLFSCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSLYICLPALLECPPFQTERRESWS 600
KESLFSCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSLYICLPALLECPPFQTERRESWS
Sbjct: 541 KESLFSCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSLYICLPALLECPPFQTERRESWS 600
Query: 601 SAPELPEELRRVVSVYQAALDLLRQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLS 660
SAPELPEELRRVVSVYQAALDLLRQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLS
Sbjct: 601 SAPELPEELRRVVSVYQAALDLLRQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLS 660
Query: 661 CFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNLLATPRAQLIQMSWTALR 720
CFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNLLATPRAQLIQMSWTALR
Sbjct: 661 CFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNLLATPRAQLIQMSWTALR 720
Query: 721 AAFPALSPAQLHRLLTHYQLASAMGPMSTWEPGAQDSPEAFRSEDVLESYENPPPIVLPS 780
AAFPALSPAQLHRLLTHYQLASAMGPMSTWEPGAQDSPEAFRSEDVLESYENPPPIVLPS
Sbjct: 721 AAFPALSPAQLHRLLTHYQLASAMGPMSTWEPGAQDSPEAFRSEDVLESYENPPPIVLPS 780
Query: 781 DGFQVDLEANCLDDSIYQHLLYVRHFLWGLRSRASPGSPGRPGSGASQPVCPEGMHHVVL 840
DGFQVDLEANCLDDSIYQHLLYVRHFLWGLRSRASPGSPGRPGSGASQPVCPEGMHHVVL
Sbjct: 781 DGFQVDLEANCLDDSIYQHLLYVRHFLWGLRSRASPGSPGRPGSGASQPVCPEGMHHVVL 840
Query: 841 DGHLEAPSCPLAPRDPGPAAREVAPERTLPLRGAPWAQAPPGRQPSRGGSQAGPPHTDSS 900
DGHLEAPSCPLAPRDPGPAAREVAPERTLPLRGAPWAQAPPGRQPSRGGSQAGPPHTDSS
Sbjct: 841 DGHLEAPSCPLAPRDPGPAAREVAPERTLPLRGAPWAQAPPGRQPSRGGSQAGPPHTDSS 900
Query: 901 CLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPA 960
CLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPA
Sbjct: 901 CLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPA 960
Query: 961 PSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRL 1020
PSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRL
Sbjct: 961 PSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRL 1020
Query: 1021 SLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKKIHFRTPPL 1075
SLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKKIHFRTPPL
Sbjct: 1021 SLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKKIHFRTPPL 1075
>gi|38570105 Ras-interacting protein 1 [Homo sapiens]
Length = 963
Score = 481 bits (1239), Expect = e-135
Identities = 315/842 (37%), Positives = 447/842 (53%), Gaps = 89/842 (10%)
Query: 47 GASDDPAELSTQLSAPGVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQ 106
G + +P + + PGVLK+FG + +G +YKSVLAT S+ARELV EALERY L
Sbjct: 130 GVAPEPPLATRATAPPGVLKIFGAGLASGANYKSVLATARSTARELVAEALERYGLAGSP 189
Query: 107 AG---------QYVLCDVVGQAGDAGQ---RWQARCFRVFGDSEKPLLIQELWKPREGLS 154
G + LCD +G+ AG W+A RV GDSE+PLL+QELW+ R G +
Sbjct: 190 GGGPGESSCVDAFALCDALGRPAAAGVGSGEWRAEHLRVLGDSERPLLVQELWRARPGWA 249
Query: 155 RRFELRKRSDVEELAAKEVDTITA-GINAQARRLQRSRAKG--------TPTPALGDA-- 203
RRFELR R + L + + G A + R Q++R++ +P P G
Sbjct: 250 RRFELRGREEARRLEQEAFGAADSEGTGAPSWRPQKNRSRAASGGAALASPGPGTGSGAP 309
Query: 204 ------RSSPPPRLRRTVSETSLS------------PVNALPAAAQ---GPEEPGP-DAM 241
S LRR+VSE SL ++ P AA G +PG D +
Sbjct: 310 AGSGGKERSENLSLRRSVSELSLQGRRRRQQERRQQALSMAPGAADAQIGTADPGDFDQL 369
Query: 242 RYSLYQSP----HLLLLQGYSQQHDSLVYVLNRDRHTVGQ------RTPSSKPSIS--LS 289
L Q+P + LLLQGY D +VYV+ R++H G+ R S P + L+
Sbjct: 370 TQCLIQAPSNRPYFLLLQGYQDAQDFVVYVMTREQHVFGRGGNSSGRGGSPAPYVDTFLN 429
Query: 290 APDILPLHCTIRRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGL 349
APDILP HCT+R P + ++ P GA ++ N + R LH GDLL LG
Sbjct: 430 APDILPRHCTVRAGPEHPA-------MVRPSRGAPVTHNGCLL-LREAELHPGDLLGLGE 481
Query: 350 YYLLLFKDPAQAQPLPARAL---ARLRAVPQ------SCRLCGAALGARGAASPTQAALP 400
++L ++KDP PAR AR A P SCRLCG L RG A AA
Sbjct: 482 HFLFMYKDPRTGGSGPARPPWLPARPGATPPGPGWAFSCRLCGRGLQERGEAL---AAYL 538
Query: 401 RRQQLLLEFEPHLEDTLLQRIMTLIEPG-GDDHKLTPAFLLCLCIQHSATHFQPGTFGQL 459
++ +L F P E+ LL I+ G GD L PA LL LC+QHSA + G +L
Sbjct: 539 DGREPVLRFRPREEEALLGEIVRAAAAGSGDLPPLGPATLLALCVQHSARELELGHLPRL 598
Query: 460 LLKIARLIRETVWEKTKELAEKQAQLQ-EPISLASCAMADLVPDLQPILFWMSNSIELLY 518
L ++ARLI+E VWEK KE+ ++Q + E + + +L+P++ WM+N+ ELL
Sbjct: 599 LGRLARLIKEAVWEKIKEIGDRQPENHPEGVPEVPLTPEAVSVELRPLMLWMANTTELLS 658
Query: 519 FIQQKCPLYMQSMEEQLDITGSKESLFSCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSL 578
F+Q+K + ME++ D ++ L +EAMA+L+EV++ FQQ VYY++K+L
Sbjct: 659 FVQEK----VLEMEKEAD---QEDPQLCNDLELCDEAMALLDEVIMCTFQQSVYYLTKTL 711
Query: 579 YICLPALLECPPFQT--ERRESWSSAPELPEELRRVVSVYQAALDLLRQLQVHPEVASQM 636
Y LPALL+ PF E + +P LR + V+QAAL+L Q ++HP++ SQ
Sbjct: 712 YSTLPALLDSNPFTAGAELPGPGAELGAMPPGLRPTLGVFQAALELTSQCELHPDLVSQT 771
Query: 637 LAYLFFFSGTLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQK 696
YLFFFS LLN L++RG + W R VQ L +L+W++ AG G FF+K
Sbjct: 772 FGYLFFFSNASLLNSLMERGQGRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRK 831
Query: 697 LSCTLNLLATPRAQLIQMSWTALRAAFPALSPAQLHRLLTHYQLASAMGPMSTWEPGAQD 756
LS +NLL PR L++ SW++LR P L+PAQLH LL+HYQL GP + W+P +
Sbjct: 832 LSMAVNLLCVPRTSLLKASWSSLRTDHPTLTPAQLHHLLSHYQLGPGRGPPAAWDPPPAE 891
Query: 757 SPEAFRSEDVLESYENPPPIVLPSDGFQVDLEANCLDDSIYQHLLYVRHFLWGLRSRASP 816
EA + D+ ES+ + PP++LP ++ L DD++++ L +R LW L + P
Sbjct: 892 R-EAVDTGDIFESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELP 950
Query: 817 GS 818
+
Sbjct: 951 AN 952
>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 1 [Homo
sapiens]
Length = 1834
Score = 75.5 bits (184), Expect = 3e-13
Identities = 168/798 (21%), Positives = 275/798 (34%), Gaps = 168/798 (21%)
Query: 63 GVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAGDA 122
G L+++ DS+ YK++L + T A V EALE+Y L+ Y + V+ G
Sbjct: 247 GTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVMLPPGAQ 306
Query: 123 GQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKR--SDVEELAAKEVDTITAGI 180
+ + D E PL I W +G+ F+L++R + + K ++ T
Sbjct: 307 HSDEKGAKEIILDDDECPLQIFREWPSDKGI-LVFQLKRRPPDHIPKKTKKHLEGKTP-- 363
Query: 181 NAQARRLQRSRAKGTPTPALGDARSSPPPRLRRTVSETSLSPVNALPAAAQGPEEPGPDA 240
+ RA G+ G + PP +L V E P
Sbjct: 364 ------KGKERADGS-----GYGSTLPPEKLPYLV-------------------ELSPGR 393
Query: 241 MRYSLYQSPHLLLLQGYSQQHDSLVYVLNRDRHTVGQRTPSSKPSISLSAPDILPLHCTI 300
+ Y + H G + +Y L VG SI L P I P HC +
Sbjct: 394 RNHFAYYNYH-TYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDN-SIQLFGPGIQPHHCDL 451
Query: 301 RRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQ 360
+ + G IS T +L G + G ++ F DP+Q
Sbjct: 452 TNMDGVVTVTPRSMDAETYVEGQRIS--------ETTMLQSGMKVQFGASHVFKFVDPSQ 503
Query: 361 AQPLPARAL------------------------------ARLRAVPQSCRL------CGA 384
L R++ L + RL +
Sbjct: 504 DHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSAS 563
Query: 385 ALGARGAASP----TQAALPRRQ----------QLLL----EFEPHLEDTLLQRIMTLIE 426
+ RG P Q RRQ +L+L EF ED+ L I+
Sbjct: 564 STAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTN 623
Query: 427 PGGDDHKLTPAFLLCL-CIQHSATHFQPGTFGQLLLKIARLIRETVWEKTKELAEKQAQL 485
KL+P ++L + C + ++P + + + K ++ + +
Sbjct: 624 SSTVHFKLSPTYVLYMACRYVLSNQYRPD------ISPTERTHKVIAVVNKMVSMMEGVI 677
Query: 486 QEPISLASCAMADLVPDLQPILFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGSKESLF 545
Q+ ++A + FWM+N+ ELL FI+Q L
Sbjct: 678 QKQKNIAGA-----------LAFWMANASELLNFIKQ------------------DRDLS 708
Query: 546 SCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSLYICLPALLECPPFQTERRESWSSAPEL 605
TL A + VL +V AF+ V+ + L +PA L+ P E+ P++
Sbjct: 709 RITLDAQD----VLAHLVQMAFKYLVHCLQSELNNYMPAFLDDP------EENSLQRPKI 758
Query: 606 PEELRRVVSVYQAALDLLRQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLSCFHWP 665
+ V+ A+ LLR+ +V+ + Q+ + LF F L N+L+ S C H+
Sbjct: 759 DD----VLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHY- 813
Query: 666 RGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNLLATPR---AQLIQMSWTALRAA 722
G +L + W G A + ++ LL + + ++ T +
Sbjct: 814 WGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFK-- 871
Query: 723 FPALSPAQLHRLLTHYQLA--SAMGPMSTWE----PGAQDSPEAFRSEDVLESYENPP-- 774
L+ QL LL +Y A P E + E RS+ E P
Sbjct: 872 ---LNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDL 928
Query: 775 --PIVLPSDGFQVDLEAN 790
P +LP DG+ D+ N
Sbjct: 929 QLPFLLPEDGYSCDVVRN 946
Score = 53.5 bits (127), Expect = 1e-06
Identities = 28/86 (32%), Positives = 50/86 (58%), Gaps = 1/86 (1%)
Query: 974 VFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSS 1033
+ TV L++ +G+G+ ++ G+Y+++++ G A DGRL+ GD++L V+G S
Sbjct: 1006 IITVTLKK-QNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1064
Query: 1034 LLGLGYLRAVDLIRHGGKKMRFLVAK 1059
L+GL RA +L+ + VAK
Sbjct: 1065 LVGLSQERAAELMTRTSSVVTLEVAK 1090
>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 2 [Homo
sapiens]
Length = 1651
Score = 75.5 bits (184), Expect = 3e-13
Identities = 168/798 (21%), Positives = 275/798 (34%), Gaps = 168/798 (21%)
Query: 63 GVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAGDA 122
G L+++ DS+ YK++L + T A V EALE+Y L+ Y + V+ G
Sbjct: 248 GTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVMLPPGAQ 307
Query: 123 GQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKR--SDVEELAAKEVDTITAGI 180
+ + D E PL I W +G+ F+L++R + + K ++ T
Sbjct: 308 HSDEKGAKEIILDDDECPLQIFREWPSDKGI-LVFQLKRRPPDHIPKKTKKHLEGKTP-- 364
Query: 181 NAQARRLQRSRAKGTPTPALGDARSSPPPRLRRTVSETSLSPVNALPAAAQGPEEPGPDA 240
+ RA G+ G + PP +L V E P
Sbjct: 365 ------KGKERADGS-----GYGSTLPPEKLPYLV-------------------ELSPGR 394
Query: 241 MRYSLYQSPHLLLLQGYSQQHDSLVYVLNRDRHTVGQRTPSSKPSISLSAPDILPLHCTI 300
+ Y + H G + +Y L VG SI L P I P HC +
Sbjct: 395 RNHFAYYNYH-TYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDN-SIQLFGPGIQPHHCDL 452
Query: 301 RRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQ 360
+ + G IS T +L G + G ++ F DP+Q
Sbjct: 453 TNMDGVVTVTPRSMDAETYVEGQRIS--------ETTMLQSGMKVQFGASHVFKFVDPSQ 504
Query: 361 AQPLPARAL------------------------------ARLRAVPQSCRL------CGA 384
L R++ L + RL +
Sbjct: 505 DHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSAS 564
Query: 385 ALGARGAASP----TQAALPRRQ----------QLLL----EFEPHLEDTLLQRIMTLIE 426
+ RG P Q RRQ +L+L EF ED+ L I+
Sbjct: 565 STAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTN 624
Query: 427 PGGDDHKLTPAFLLCL-CIQHSATHFQPGTFGQLLLKIARLIRETVWEKTKELAEKQAQL 485
KL+P ++L + C + ++P + + + K ++ + +
Sbjct: 625 SSTVHFKLSPTYVLYMACRYVLSNQYRPD------ISPTERTHKVIAVVNKMVSMMEGVI 678
Query: 486 QEPISLASCAMADLVPDLQPILFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGSKESLF 545
Q+ ++A + FWM+N+ ELL FI+Q L
Sbjct: 679 QKQKNIAGA-----------LAFWMANASELLNFIKQ------------------DRDLS 709
Query: 546 SCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSLYICLPALLECPPFQTERRESWSSAPEL 605
TL A + VL +V AF+ V+ + L +PA L+ P E+ P++
Sbjct: 710 RITLDAQD----VLAHLVQMAFKYLVHCLQSELNNYMPAFLDDP------EENSLQRPKI 759
Query: 606 PEELRRVVSVYQAALDLLRQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLSCFHWP 665
+ V+ A+ LLR+ +V+ + Q+ + LF F L N+L+ S C H+
Sbjct: 760 DD----VLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHY- 814
Query: 666 RGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNLLATPR---AQLIQMSWTALRAA 722
G +L + W G A + ++ LL + + ++ T +
Sbjct: 815 WGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFK-- 872
Query: 723 FPALSPAQLHRLLTHYQLA--SAMGPMSTWE----PGAQDSPEAFRSEDVLESYENPP-- 774
L+ QL LL +Y A P E + E RS+ E P
Sbjct: 873 ---LNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDL 929
Query: 775 --PIVLPSDGFQVDLEAN 790
P +LP DG+ D+ N
Sbjct: 930 QLPFLLPEDGYSCDVVRN 947
Score = 53.5 bits (127), Expect = 1e-06
Identities = 28/86 (32%), Positives = 50/86 (58%), Gaps = 1/86 (1%)
Query: 974 VFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSS 1033
+ TV L++ +G+G+ ++ G+Y+++++ G A DGRL+ GD++L V+G S
Sbjct: 1007 IITVTLKK-QNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1065
Query: 1034 LLGLGYLRAVDLIRHGGKKMRFLVAK 1059
L+GL RA +L+ + VAK
Sbjct: 1066 LVGLSQERAAELMTRTSSVVTLEVAK 1091
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 71.2 bits (173), Expect = 5e-12
Identities = 37/111 (33%), Positives = 63/111 (56%), Gaps = 10/111 (9%)
Query: 957 SPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAA 1016
SPP P +F VEL + + LG+ + G++T + G+Y++ ++P A +
Sbjct: 1168 SPPKPGD----------IFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAES 1217
Query: 1017 DGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKK 1067
DGR+ GDR+L VNG SL G + +AV+ +R+ G+ + L+ K T+K+
Sbjct: 1218 DGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1268
Score = 52.0 bits (123), Expect = 3e-06
Identities = 32/114 (28%), Positives = 58/114 (50%), Gaps = 8/114 (7%)
Query: 954 AEESPPAPSSRSSSTEDFCYV-----FTVELERGPSGLGMGLI---DGMHTHLGAPGLYI 1005
A+ P +++ +D+ +V F V+L + SGLG + + + A + +
Sbjct: 1283 AQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRV 1342
Query: 1006 QTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
+ L PG PAA G++ +GD IL+VNG+SL GL + +R ++ L+ +
Sbjct: 1343 KKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1396
Score = 48.9 bits (115), Expect = 3e-05
Identities = 24/82 (29%), Positives = 47/82 (57%)
Query: 985 GLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVD 1044
GLG +I G G++I ++ PG PA DG L GDR++ VN SL G+ + A++
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 1045 LIRHGGKKMRFLVAKSDVETAK 1066
++++ + + ++++ + +K
Sbjct: 972 ILQNAPEDVTLVISQPKEKISK 993
Score = 42.4 bits (98), Expect = 0.002
Identities = 19/58 (32%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Query: 1002 GLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
G Y+ ++ PA +DGRL GDR+++VN + + + + AV+L+R K +R ++ +
Sbjct: 1620 GCYVHDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1676
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 71.2 bits (173), Expect = 5e-12
Identities = 37/111 (33%), Positives = 63/111 (56%), Gaps = 10/111 (9%)
Query: 957 SPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAA 1016
SPP P +F VEL + + LG+ + G++T + G+Y++ ++P A +
Sbjct: 1359 SPPKPGD----------IFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAES 1408
Query: 1017 DGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKK 1067
DGR+ GDR+L VNG SL G + +AV+ +R+ G+ + L+ K T+K+
Sbjct: 1409 DGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1459
Score = 52.0 bits (123), Expect = 3e-06
Identities = 32/114 (28%), Positives = 58/114 (50%), Gaps = 8/114 (7%)
Query: 954 AEESPPAPSSRSSSTEDFCYV-----FTVELERGPSGLGMGLI---DGMHTHLGAPGLYI 1005
A+ P +++ +D+ +V F V+L + SGLG + + + A + +
Sbjct: 1474 AQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRV 1533
Query: 1006 QTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
+ L PG PAA G++ +GD IL+VNG+SL GL + +R ++ L+ +
Sbjct: 1534 KKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1587
Score = 48.9 bits (115), Expect = 3e-05
Identities = 24/82 (29%), Positives = 47/82 (57%)
Query: 985 GLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVD 1044
GLG +I G G++I ++ PG PA DG L GDR++ VN SL G+ + A++
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 1045 LIRHGGKKMRFLVAKSDVETAK 1066
++++ + + ++++ + +K
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISK 1184
Score = 42.4 bits (98), Expect = 0.002
Identities = 19/58 (32%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Query: 1002 GLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
G Y+ ++ PA +DGRL GDR+++VN + + + + AV+L+R K +R ++ +
Sbjct: 1811 GCYVHDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1867
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 71.2 bits (173), Expect = 5e-12
Identities = 37/111 (33%), Positives = 63/111 (56%), Gaps = 10/111 (9%)
Query: 957 SPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAA 1016
SPP P +F VEL + + LG+ + G++T + G+Y++ ++P A +
Sbjct: 1340 SPPKPGD----------IFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAES 1389
Query: 1017 DGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKK 1067
DGR+ GDR+L VNG SL G + +AV+ +R+ G+ + L+ K T+K+
Sbjct: 1390 DGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1440
Score = 52.0 bits (123), Expect = 3e-06
Identities = 32/114 (28%), Positives = 58/114 (50%), Gaps = 8/114 (7%)
Query: 954 AEESPPAPSSRSSSTEDFCYV-----FTVELERGPSGLGMGLI---DGMHTHLGAPGLYI 1005
A+ P +++ +D+ +V F V+L + SGLG + + + A + +
Sbjct: 1455 AQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRV 1514
Query: 1006 QTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
+ L PG PAA G++ +GD IL+VNG+SL GL + +R ++ L+ +
Sbjct: 1515 KKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1568
Score = 48.9 bits (115), Expect = 3e-05
Identities = 24/82 (29%), Positives = 47/82 (57%)
Query: 985 GLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVD 1044
GLG +I G G++I ++ PG PA DG L GDR++ VN SL G+ + A++
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143
Query: 1045 LIRHGGKKMRFLVAKSDVETAK 1066
++++ + + ++++ + +K
Sbjct: 1144 ILQNAPEDVTLVISQPKEKISK 1165
Score = 42.4 bits (98), Expect = 0.002
Identities = 19/58 (32%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Query: 1002 GLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
G Y+ ++ PA +DGRL GDR+++VN + + + + AV+L+R K +R ++ +
Sbjct: 1792 GCYVHDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1848
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 71.2 bits (173), Expect = 5e-12
Identities = 56/172 (32%), Positives = 78/172 (45%), Gaps = 21/172 (12%)
Query: 893 GPPHTDSSCLLTPP--STPLGPE-----PGDPDWPESGGPCGKALPERQRNGLSGLRGAA 945
GPP +S +P P+G PGD E G GK + R+ S
Sbjct: 942 GPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALE--GEIGKDVSTSYRHSWS------ 993
Query: 946 PEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYI 1005
D LA+ S S + VELERGP G G L G ++G L+I
Sbjct: 994 ---DHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMG---LFI 1047
Query: 1006 QTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLV 1057
L PA DGR+ +GD+I+E+NG G+ + RA++LI+ GG K+ L+
Sbjct: 1048 LRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 37.4 bits (85), Expect = 0.077
Identities = 19/46 (41%), Positives = 27/46 (58%)
Query: 1005 IQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGG 1050
I ++ GSPA G+L +GD I VNG S++ L + V LI+ G
Sbjct: 882 IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAG 927
Score = 37.0 bits (84), Expect = 0.10
Identities = 20/69 (28%), Positives = 37/69 (53%), Gaps = 3/69 (4%)
Query: 979 LERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLG 1038
L++ G G +I G L ++ +L PAA DG+++ GD I+++NG+ +LG
Sbjct: 413 LKKSTMGFGFTIIGGDRPD---EFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHT 469
Query: 1039 YLRAVDLIR 1047
+ V + +
Sbjct: 470 HADVVQMFQ 478
Score = 35.4 bits (80), Expect = 0.29
Identities = 25/106 (23%), Positives = 49/106 (46%), Gaps = 7/106 (6%)
Query: 941 LRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGA 1000
+R +P+ D + + +S + +T+D V L + SG G ++ G
Sbjct: 695 IRSGSPKLDPSEVYLKSKTLYEDKPPNTKDL----DVFLRKQESGFGFRVLGGDGPD--- 747
Query: 1001 PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLI 1046
+YI ++P A DGRL D ++ ++G + G + + +DL+
Sbjct: 748 QSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
Score = 31.2 bits (69), Expect = 5.5
Identities = 32/116 (27%), Positives = 52/116 (44%), Gaps = 16/116 (13%)
Query: 934 QRNGLSG--LRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLI 991
++NG SG L G G S A +E+ SS SS E + T+ L +GP G G +
Sbjct: 539 EQNGKSGHTLTGDGLNGPSDA-SEQRVSMASSGSSQPE----LVTIPLIKGPKGFGFAIA 593
Query: 992 DGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIR 1047
D G ++ +L L GD I E+ ++ L +L+ V++++
Sbjct: 594 D------SPTGQKVKMILDSQWCQG---LQKGDIIKEIYHQNVQNLTHLQVVEVLK 640
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 71.2 bits (173), Expect = 5e-12
Identities = 56/172 (32%), Positives = 78/172 (45%), Gaps = 21/172 (12%)
Query: 893 GPPHTDSSCLLTPP--STPLGPE-----PGDPDWPESGGPCGKALPERQRNGLSGLRGAA 945
GPP +S +P P+G PGD E G GK + R+ S
Sbjct: 942 GPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALE--GEIGKDVSTSYRHSWS------ 993
Query: 946 PEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYI 1005
D LA+ S S + VELERGP G G L G ++G L+I
Sbjct: 994 ---DHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMG---LFI 1047
Query: 1006 QTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLV 1057
L PA DGR+ +GD+I+E+NG G+ + RA++LI+ GG K+ L+
Sbjct: 1048 LRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 37.4 bits (85), Expect = 0.077
Identities = 19/46 (41%), Positives = 27/46 (58%)
Query: 1005 IQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGG 1050
I ++ GSPA G+L +GD I VNG S++ L + V LI+ G
Sbjct: 882 IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAG 927
Score = 37.0 bits (84), Expect = 0.10
Identities = 20/69 (28%), Positives = 37/69 (53%), Gaps = 3/69 (4%)
Query: 979 LERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLG 1038
L++ G G +I G L ++ +L PAA DG+++ GD I+++NG+ +LG
Sbjct: 413 LKKSTMGFGFTIIGGDRPD---EFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHT 469
Query: 1039 YLRAVDLIR 1047
+ V + +
Sbjct: 470 HADVVQMFQ 478
Score = 35.4 bits (80), Expect = 0.29
Identities = 25/106 (23%), Positives = 49/106 (46%), Gaps = 7/106 (6%)
Query: 941 LRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGA 1000
+R +P+ D + + +S + +T+D V L + SG G ++ G
Sbjct: 695 IRSGSPKLDPSEVYLKSKTLYEDKPPNTKDL----DVFLRKQESGFGFRVLGGDGPD--- 747
Query: 1001 PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLI 1046
+YI ++P A DGRL D ++ ++G + G + + +DL+
Sbjct: 748 QSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
Score = 31.2 bits (69), Expect = 5.5
Identities = 32/116 (27%), Positives = 52/116 (44%), Gaps = 16/116 (13%)
Query: 934 QRNGLSG--LRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLI 991
++NG SG L G G S A +E+ SS SS E + T+ L +GP G G +
Sbjct: 539 EQNGKSGHTLTGDGLNGPSDA-SEQRVSMASSGSSQPE----LVTIPLIKGPKGFGFAIA 593
Query: 992 DGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIR 1047
D G ++ +L L GD I E+ ++ L +L+ V++++
Sbjct: 594 D------SPTGQKVKMILDSQWCQG---LQKGDIIKEIYHQNVQNLTHLQVVEVLK 640
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 69.7 bits (169), Expect = 1e-11
Identities = 61/217 (28%), Positives = 97/217 (44%), Gaps = 27/217 (12%)
Query: 845 EAPSCPLAPRDPGPAAREVAPERTLPLRGAP--WAQAPPGRQPSRGGSQAGPPHTDSSCL 902
++P +P P + AP + L L+G + RQ + + PP TD
Sbjct: 1036 QSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQ-PPFTDYR-- 1092
Query: 903 LTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPAPS 962
PP P GD P L RQ L R +P+ L++ P
Sbjct: 1093 -QPPLDYRQPPGGDYQQPPP-------LDYRQPP-LLDYRQHSPDTRQYPLSDYRQP--- 1140
Query: 963 SRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSL 1022
+DF Y FTV++E+G G G + G + LY+ L PA +GR+ +
Sbjct: 1141 ------QDFDY-FTVDMEKGAKGFGFSIRGGREYKMD---LYVLRLAEDGPAIRNGRMRV 1190
Query: 1023 GDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
GD+I+E+NG S + + RA++LI+ GG+++R L+ +
Sbjct: 1191 GDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKR 1227
Score = 48.5 bits (114), Expect = 3e-05
Identities = 38/134 (28%), Positives = 60/134 (44%), Gaps = 10/134 (7%)
Query: 927 GKALPERQRN-GLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFC----YVFTVELER 981
G+ PE R+ G ++P D A + APSS +S E F V + R
Sbjct: 866 GEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHR 925
Query: 982 GPS-GLGMGLIDGMHTHLGAPGLYIQ----TLLPGSPAAADGRLSLGDRILEVNGSSLLG 1036
+ G G +I ++ + + ++ GSPA +L +GDRIL VNG S++
Sbjct: 926 KENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIIN 985
Query: 1037 LGYLRAVDLIRHGG 1050
+ + V LI+ G
Sbjct: 986 MPHADIVKLIKDAG 999
Score = 41.2 bits (95), Expect = 0.005
Identities = 42/159 (26%), Positives = 64/159 (40%), Gaps = 10/159 (6%)
Query: 893 GPPHTDSSCLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAA 952
G P T S P + P P +P+S +A R+ + + +S
Sbjct: 702 GSPQTSLSAPAIPQNLPFPPALHRSSFPDST----EAFDPRKPDPYELYEKSRAIYESR- 756
Query: 953 LAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGS 1012
++ PP S R S+ V L R SG G ++ G G P L + GS
Sbjct: 757 --QQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEP--GQPILIGAVIAMGS 812
Query: 1013 PAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGK 1051
A DGRL GD ++ V+G + G + +DL+ H +
Sbjct: 813 -ADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAAR 850
Score = 34.3 bits (77), Expect = 0.65
Identities = 20/69 (28%), Positives = 35/69 (50%), Gaps = 3/69 (4%)
Query: 979 LERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLG 1038
L++ G G +I G L +++++P PAA DG++ GD I+ +N +LG
Sbjct: 429 LKKSNMGFGFTIIGGDEPD---EFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHT 485
Query: 1039 YLRAVDLIR 1047
+ V L +
Sbjct: 486 HADVVKLFQ 494
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 67.4 bits (163), Expect = 7e-11
Identities = 34/98 (34%), Positives = 58/98 (59%), Gaps = 6/98 (6%)
Query: 964 RSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLG 1023
+++ +DF +TVELERG G G L G ++ LY+ L PA G++ +G
Sbjct: 1143 QATQEQDF---YTVELERGAKGFGFSLRGGREYNMD---LYVLRLAEDGPAERCGKMRIG 1196
Query: 1024 DRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSD 1061
D ILE+NG + + + RA++LI++GG+++R + + D
Sbjct: 1197 DEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGD 1234
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/126 (26%), Positives = 48/126 (38%), Gaps = 11/126 (8%)
Query: 939 SGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGL---GMGLIDGMH 995
SG+ G P R E F +V + R +G G + H
Sbjct: 977 SGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPH 1036
Query: 996 THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRF 1055
I ++ GSPA G+L +GDRIL VNG S+ + V+LI+ G +
Sbjct: 1037 K--------IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL 1088
Query: 1056 LVAKSD 1061
+ D
Sbjct: 1089 RIIPGD 1094
Score = 37.7 bits (86), Expect = 0.059
Identities = 50/201 (24%), Positives = 82/201 (40%), Gaps = 30/201 (14%)
Query: 873 GAPWAQAPPGRQP-SRGGSQAGPPHTDSSCLLTPPSTPLGPEPGDPDWPESGGPCGKALP 931
G P + P QP R SQ H+ SS ++P P++P P P
Sbjct: 723 GLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFP----PAEAQAP 778
Query: 932 ERQRNGLSGLRGAAPE---GDSAALAEESPPAPSSRS------------SSTEDFCYVFT 976
++ + SG + P S ++ E P +PS S S+ C +
Sbjct: 779 DQTDS--SGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPD 836
Query: 977 VE-----LERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNG 1031
+ L R +G G ++ G G P +YI ++P A DGRL GD ++ V+G
Sbjct: 837 YQEQDIFLWRKETGFGFRILGGNEP--GEP-IYIGHIVPLGAADTDGRLRSGDELICVDG 893
Query: 1032 SSLLGLGYLRAVDLIRHGGKK 1052
+ ++G + V L++ K+
Sbjct: 894 TPVIGKSHQLVVQLMQQAAKQ 914
Score = 36.6 bits (83), Expect = 0.13
Identities = 34/134 (25%), Positives = 60/134 (44%), Gaps = 9/134 (6%)
Query: 936 NGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMH 995
NG+ R ++P ++ + P S +SS + TV + +GP G G + D
Sbjct: 603 NGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSP- 661
Query: 996 THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRH--GGKKM 1053
G G ++ ++ SP L GD I+EVN ++ L + + VD++ G ++
Sbjct: 662 ---GGGGQRVKQIV-DSPRCRG--LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEV 715
Query: 1054 RFLVAKSDVETAKK 1067
LV + + KK
Sbjct: 716 TLLVQRGGLPVPKK 729
Score = 34.3 bits (77), Expect = 0.65
Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 978 ELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGL 1037
+L + G G ++ G L I++L+ PAA DG++ GD I+ VN + +LG
Sbjct: 474 KLRKSSRGFGFTVVGGDEPD---EFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
Query: 1038 GYLRAVDLIR 1047
+ + V + +
Sbjct: 531 THAQVVKIFQ 540
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 67.4 bits (163), Expect = 7e-11
Identities = 34/98 (34%), Positives = 58/98 (59%), Gaps = 6/98 (6%)
Query: 964 RSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLG 1023
+++ +DF +TVELERG G G L G ++ LY+ L PA G++ +G
Sbjct: 1114 QATQEQDF---YTVELERGAKGFGFSLRGGREYNMD---LYVLRLAEDGPAERCGKMRIG 1167
Query: 1024 DRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSD 1061
D ILE+NG + + + RA++LI++GG+++R + + D
Sbjct: 1168 DEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGD 1205
Score = 44.7 bits (104), Expect = 5e-04
Identities = 33/123 (26%), Positives = 47/123 (38%), Gaps = 6/123 (4%)
Query: 939 SGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHL 998
SG+ G P R E F +V + R +G G H
Sbjct: 949 SGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHK 1008
Query: 999 GAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVA 1058
I ++ GSPA G+L +GDRIL VNG S+ + V+LI+ G + +
Sbjct: 1009 ------IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1062
Query: 1059 KSD 1061
D
Sbjct: 1063 PGD 1065
Score = 37.4 bits (85), Expect = 0.077
Identities = 23/74 (31%), Positives = 39/74 (52%), Gaps = 3/74 (4%)
Query: 979 LERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLG 1038
L R +G G ++ G G P +YI ++P A DGRL GD ++ V+G+ ++G
Sbjct: 816 LWRKETGFGFRILGGNEP--GEP-IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 872
Query: 1039 YLRAVDLIRHGGKK 1052
+ V L++ K+
Sbjct: 873 HQLVVQLMQQAAKQ 886
Score = 36.6 bits (83), Expect = 0.13
Identities = 34/134 (25%), Positives = 60/134 (44%), Gaps = 9/134 (6%)
Query: 936 NGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMH 995
NG+ R ++P ++ + P S +SS + TV + +GP G G + D
Sbjct: 603 NGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSP- 661
Query: 996 THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRH--GGKKM 1053
G G ++ ++ SP L GD I+EVN ++ L + + VD++ G ++
Sbjct: 662 ---GGGGQRVKQIV-DSPRCRG--LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEV 715
Query: 1054 RFLVAKSDVETAKK 1067
LV + + KK
Sbjct: 716 TLLVQRGGLPVPKK 729
Score = 34.3 bits (77), Expect = 0.65
Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 978 ELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGL 1037
+L + G G ++ G L I++L+ PAA DG++ GD I+ VN + +LG
Sbjct: 474 KLRKSSRGFGFTVVGGDEPD---EFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
Query: 1038 GYLRAVDLIR 1047
+ + V + +
Sbjct: 531 THAQVVKIFQ 540
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 67.4 bits (163), Expect = 7e-11
Identities = 34/98 (34%), Positives = 58/98 (59%), Gaps = 6/98 (6%)
Query: 964 RSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLG 1023
+++ +DF +TVELERG G G L G ++ LY+ L PA G++ +G
Sbjct: 1142 QATQEQDF---YTVELERGAKGFGFSLRGGREYNMD---LYVLRLAEDGPAERCGKMRIG 1195
Query: 1024 DRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSD 1061
D ILE+NG + + + RA++LI++GG+++R + + D
Sbjct: 1196 DEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGD 1233
Score = 44.7 bits (104), Expect = 5e-04
Identities = 33/123 (26%), Positives = 47/123 (38%), Gaps = 6/123 (4%)
Query: 939 SGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHL 998
SG+ G P R E F +V + R +G G H
Sbjct: 977 SGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHK 1036
Query: 999 GAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVA 1058
I ++ GSPA G+L +GDRIL VNG S+ + V+LI+ G + +
Sbjct: 1037 ------IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1090
Query: 1059 KSD 1061
D
Sbjct: 1091 PGD 1093
Score = 37.7 bits (86), Expect = 0.059
Identities = 50/201 (24%), Positives = 82/201 (40%), Gaps = 30/201 (14%)
Query: 873 GAPWAQAPPGRQP-SRGGSQAGPPHTDSSCLLTPPSTPLGPEPGDPDWPESGGPCGKALP 931
G P + P QP R SQ H+ SS ++P P++P P P
Sbjct: 723 GLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFP----PAEAQAP 778
Query: 932 ERQRNGLSGLRGAAPE---GDSAALAEESPPAPSSRS------------SSTEDFCYVFT 976
++ + SG + P S ++ E P +PS S S+ C +
Sbjct: 779 DQTDS--SGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPD 836
Query: 977 VE-----LERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNG 1031
+ L R +G G ++ G G P +YI ++P A DGRL GD ++ V+G
Sbjct: 837 YQEQDIFLWRKETGFGFRILGGNEP--GEP-IYIGHIVPLGAADTDGRLRSGDELICVDG 893
Query: 1032 SSLLGLGYLRAVDLIRHGGKK 1052
+ ++G + V L++ K+
Sbjct: 894 TPVIGKSHQLVVQLMQQAAKQ 914
Score = 36.6 bits (83), Expect = 0.13
Identities = 34/134 (25%), Positives = 60/134 (44%), Gaps = 9/134 (6%)
Query: 936 NGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMH 995
NG+ R ++P ++ + P S +SS + TV + +GP G G + D
Sbjct: 603 NGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSP- 661
Query: 996 THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRH--GGKKM 1053
G G ++ ++ SP L GD I+EVN ++ L + + VD++ G ++
Sbjct: 662 ---GGGGQRVKQIV-DSPRCRG--LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEV 715
Query: 1054 RFLVAKSDVETAKK 1067
LV + + KK
Sbjct: 716 TLLVQRGGLPVPKK 729
Score = 34.3 bits (77), Expect = 0.65
Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 978 ELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGL 1037
+L + G G ++ G L I++L+ PAA DG++ GD I+ VN + +LG
Sbjct: 474 KLRKSSRGFGFTVVGGDEPD---EFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
Query: 1038 GYLRAVDLIR 1047
+ + V + +
Sbjct: 531 THAQVVKIFQ 540
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 65.1 bits (157), Expect = 3e-10
Identities = 37/116 (31%), Positives = 63/116 (54%), Gaps = 15/116 (12%)
Query: 957 SPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLI-----DGMHTHLGAPGLYIQTLLPG 1011
SPP P +F VEL + + LG+ + G++T + G+Y++ ++P
Sbjct: 1359 SPPKPGD----------IFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQ 1408
Query: 1012 SPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKK 1067
A +DGR+ GDR+L VNG SL G + +AV+ +R+ G+ + L+ K T+K+
Sbjct: 1409 GAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1464
Score = 52.0 bits (123), Expect = 3e-06
Identities = 32/114 (28%), Positives = 58/114 (50%), Gaps = 8/114 (7%)
Query: 954 AEESPPAPSSRSSSTEDFCYV-----FTVELERGPSGLGMGLI---DGMHTHLGAPGLYI 1005
A+ P +++ +D+ +V F V+L + SGLG + + + A + +
Sbjct: 1479 AQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRV 1538
Query: 1006 QTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
+ L PG PAA G++ +GD IL+VNG+SL GL + +R ++ L+ +
Sbjct: 1539 KKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1592
Score = 48.9 bits (115), Expect = 3e-05
Identities = 24/82 (29%), Positives = 47/82 (57%)
Query: 985 GLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVD 1044
GLG +I G G++I ++ PG PA DG L GDR++ VN SL G+ + A++
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 1045 LIRHGGKKMRFLVAKSDVETAK 1066
++++ + + ++++ + +K
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISK 1184
Score = 42.4 bits (98), Expect = 0.002
Identities = 19/58 (32%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Query: 1002 GLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
G Y+ ++ PA +DGRL GDR+++VN + + + + AV+L+R K +R ++ +
Sbjct: 1816 GCYVHDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1872
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 63.9 bits (154), Expect = 8e-10
Identities = 40/124 (32%), Positives = 68/124 (54%), Gaps = 8/124 (6%)
Query: 942 RGAAPEGDSAALAEESPPAPSSRS--SSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLG 999
RG+ P+ S + SP A S+ S S+ + ++ T+EL SGLG G+I G T
Sbjct: 222 RGSLPQLVSP-IVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT--- 277
Query: 1000 APGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
G+ ++T+LPG A GRL GD IL++ + L G+ + ++R G +++ ++A+
Sbjct: 278 --GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR 335
Query: 1060 SDVE 1063
+E
Sbjct: 336 GAIE 339
Score = 58.9 bits (141), Expect = 2e-08
Identities = 28/72 (38%), Positives = 45/72 (62%)
Query: 976 TVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLL 1035
++ LERGP GLG ++ G + G +Y++T+ A+ DGRL GD+I+ VNG SL
Sbjct: 1958 SITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLE 2017
Query: 1036 GLGYLRAVDLIR 1047
G+ + AV +++
Sbjct: 2018 GVTHEEAVAILK 2029
Score = 57.4 bits (137), Expect = 7e-08
Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 35/177 (19%)
Query: 885 PSRGGSQAGPPHTDSSCLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGA 944
PS G+ +G S L+ P S G P+ PES +R
Sbjct: 1571 PSAAGAASGEKKNSSQSLMVPQS-------GSPE-PES------------------IRNT 1604
Query: 945 APEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLY 1004
+ A A + P T T+E+ +G +GLG+ ++ G T LGA +
Sbjct: 1605 SRSSTPAIFASDPATCPIIPGCET-------TIEISKGRTGLGLSIVGGSDTLLGA--II 1655
Query: 1005 IQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSD 1061
I + A DGRL GD+ILEVNG L + A++++R +++R + + +
Sbjct: 1656 IHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDE 1712
Score = 52.8 bits (125), Expect = 2e-06
Identities = 33/115 (28%), Positives = 65/115 (56%), Gaps = 2/115 (1%)
Query: 950 SAALAEESPPAPSSRSSSTEDFCYVFTVELERGPS-GLGMGLIDGMHTHLGAPGLYIQTL 1008
S + ES + S +++ + + TVE+++GP+ LG+ + G+ + LG ++I +
Sbjct: 1807 SGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMM 1866
Query: 1009 LPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRF-LVAKSDV 1062
P AA +L +GDRI+ + G+S G+ + +AV+L+++ + +VA DV
Sbjct: 1867 HPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDV 1921
Score = 50.1 bits (118), Expect = 1e-05
Identities = 31/111 (27%), Positives = 56/111 (50%), Gaps = 4/111 (3%)
Query: 945 APEGDSAALAEESPPAPSSR---SSSTEDFCYVFTVELERGPSGLGMGLIDGM-HTHLGA 1000
AP L+ P R S+ + F VEL + GLG+ + + L
Sbjct: 343 APTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEP 402
Query: 1001 PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGK 1051
G++++++ S DGR+ +GD+I+ V+G++L G +AV+++RH G+
Sbjct: 403 SGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQ 453
Score = 49.7 bits (117), Expect = 1e-05
Identities = 34/88 (38%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 977 VELERGPS-GLGMGLIDG--MHTHLG----APGLYIQTLLPGSPAAADGRLSLGDRILEV 1029
VEL R PS LG+ ++ G M + L G++I+ +L SPA +G L GDRI+EV
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
Query: 1030 NGSSLLGLGYLRAVDLIRHGGKKMRFLV 1057
+G L + +AV+ IR G + F+V
Sbjct: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Score = 48.9 bits (115), Expect = 3e-05
Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 2/84 (2%)
Query: 977 VELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLG 1036
+ELE+G SGLG+ L ++I + P A DGRL + D +LE+NG L G
Sbjct: 1351 IELEKGHSGLGLSLAGNKDR--SRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYG 1408
Query: 1037 LGYLRAVDLIRHGGKKMRFLVAKS 1060
+ A +I+ K++ + ++
Sbjct: 1409 RSHQNASSIIKCAPSKVKIIFIRN 1432
Score = 45.4 bits (106), Expect = 3e-04
Identities = 24/67 (35%), Positives = 39/67 (58%), Gaps = 5/67 (7%)
Query: 969 EDFCYVFTVELERGPS-GLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRIL 1027
E+ C T+EL++ P GLG+ ++ + G+++ ++ G A ADGRL GD+IL
Sbjct: 1718 EEVCDTLTIELQKKPGKGLGLSIVGKRND----TGVFVSDIVKGGIADADGRLMQGDQIL 1773
Query: 1028 EVNGSSL 1034
VNG +
Sbjct: 1774 MVNGEDV 1780
Score = 43.9 bits (102), Expect = 8e-04
Identities = 34/107 (31%), Positives = 51/107 (47%), Gaps = 9/107 (8%)
Query: 977 VELERGPSGLGMGLIDGMHT-HLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLL 1035
+ELE+G GLG ++D + + I++L+PG A DGRL GDR++ VN +L
Sbjct: 701 IELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLE 760
Query: 1036 GLGYLRAVD--------LIRHGGKKMRFLVAKSDVETAKKIHFRTPP 1074
AV+ +R G K L + +AK+ F PP
Sbjct: 761 NSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPP 807
Score = 43.5 bits (101), Expect = 0.001
Identities = 26/92 (28%), Positives = 51/92 (55%), Gaps = 2/92 (2%)
Query: 973 YVFTVELERGPSG-LGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNG 1031
+V EL + PSG LG ++ + G G+++Q + GS A DGRL D+IL +NG
Sbjct: 134 HVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAING 193
Query: 1032 SSL-LGLGYLRAVDLIRHGGKKMRFLVAKSDV 1062
+L + + +A+ +++ ++ ++A+ +
Sbjct: 194 QALDQTITHQQAISILQKAKDTVQLVIARGSL 225
Score = 41.6 bits (96), Expect = 0.004
Identities = 23/64 (35%), Positives = 37/64 (57%), Gaps = 6/64 (9%)
Query: 984 SGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAV 1043
SGLG+ L + H +I+++LP P G+L GD +LEVNG +LLG + V
Sbjct: 563 SGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVV 616
Query: 1044 DLIR 1047
++++
Sbjct: 617 NILK 620
Score = 38.1 bits (87), Expect = 0.045
Identities = 21/75 (28%), Positives = 42/75 (56%), Gaps = 10/75 (13%)
Query: 976 TVELERGPSGLGMGLI---DGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGS 1032
T+ + +G S LGM + DG+ G+ +++++ G + DGR+++GD IL +N
Sbjct: 1008 TINIAKGNSSLGMTVSANKDGL-------GMIVRSIIHGGAISRDGRIAIGDCILSINEE 1060
Query: 1033 SLLGLGYLRAVDLIR 1047
S + + +A ++R
Sbjct: 1061 STISVTNAQARAMLR 1075
Score = 36.2 bits (82), Expect = 0.17
Identities = 25/95 (26%), Positives = 49/95 (51%), Gaps = 6/95 (6%)
Query: 955 EESPPAPSSRSSSTE--DFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGS 1012
+E+ P ++ ++ + F V +EL + GLG+ + + G+ I++L
Sbjct: 1460 KETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISE----EDTLSGVIIKSLTEHG 1515
Query: 1013 PAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIR 1047
AA DGRL +GD+IL V+ ++G + + L++
Sbjct: 1516 VAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLK 1550
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 62.8 bits (151), Expect = 2e-09
Identities = 32/102 (31%), Positives = 60/102 (58%), Gaps = 5/102 (4%)
Query: 958 PPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAAD 1017
PP+P S+ ++ VEL + LG + G++T + G+Y+++++PG PAA +
Sbjct: 915 PPSPPEISAGE-----IYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKE 969
Query: 1018 GRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
G++ GDR+L+V+G L GL + +AV + G+ R ++ +
Sbjct: 970 GQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLER 1011
Score = 51.6 bits (122), Expect = 4e-06
Identities = 36/116 (31%), Positives = 59/116 (50%), Gaps = 5/116 (4%)
Query: 947 EGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMH---THLGAPGL 1003
E + +L P PSS S T+ F V+L++ +GLG + +HL + +
Sbjct: 1030 ERTAVSLVTALPGRPSSCVSVTDG--PKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV 1087
Query: 1004 YIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
I+ L PG PA +G ++ GD IL VNG S GL + + L+R +++ L+ +
Sbjct: 1088 RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 1143
Score = 46.2 bits (108), Expect = 2e-04
Identities = 25/88 (28%), Positives = 48/88 (54%), Gaps = 1/88 (1%)
Query: 974 VFTVELERGPS-GLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGS 1032
+ V L+R P G G + +G ++ PG++I +++PG PA + G +IL +N
Sbjct: 751 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810
Query: 1033 SLLGLGYLRAVDLIRHGGKKMRFLVAKS 1060
SL G + AV +I++ + ++++S
Sbjct: 811 SLEGFTFNMAVRMIQNSPDNIELIISQS 838
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 62.8 bits (151), Expect = 2e-09
Identities = 32/102 (31%), Positives = 60/102 (58%), Gaps = 5/102 (4%)
Query: 958 PPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAAD 1017
PP+P S+ ++ VEL + LG + G++T + G+Y+++++PG PAA +
Sbjct: 937 PPSPPEISAGE-----IYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKE 991
Query: 1018 GRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
G++ GDR+L+V+G L GL + +AV + G+ R ++ +
Sbjct: 992 GQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLER 1033
Score = 51.6 bits (122), Expect = 4e-06
Identities = 36/116 (31%), Positives = 59/116 (50%), Gaps = 5/116 (4%)
Query: 947 EGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMH---THLGAPGL 1003
E + +L P PSS S T+ F V+L++ +GLG + +HL + +
Sbjct: 1052 ERTAVSLVTALPGRPSSCVSVTDG--PKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV 1109
Query: 1004 YIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
I+ L PG PA +G ++ GD IL VNG S GL + + L+R +++ L+ +
Sbjct: 1110 RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 1165
Score = 46.2 bits (108), Expect = 2e-04
Identities = 25/88 (28%), Positives = 48/88 (54%), Gaps = 1/88 (1%)
Query: 974 VFTVELERGPS-GLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGS 1032
+ V L+R P G G + +G ++ PG++I +++PG PA + G +IL +N
Sbjct: 773 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 832
Query: 1033 SLLGLGYLRAVDLIRHGGKKMRFLVAKS 1060
SL G + AV +I++ + ++++S
Sbjct: 833 SLEGFTFNMAVRMIQNSPDNIELIISQS 860
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 61.6 bits (148), Expect = 4e-09
Identities = 39/115 (33%), Positives = 62/115 (53%), Gaps = 13/115 (11%)
Query: 953 LAEESPPAPSSRSSSTED--------FCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLY 1004
+A E SS SSS D + +V VEL SGLG G++ G + G+
Sbjct: 217 VAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTS-----GVV 271
Query: 1005 IQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
++T++PG A DGRL GD IL++ G+++ G+ + ++R+ G +R LVA+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 56.2 bits (134), Expect = 2e-07
Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 2/85 (2%)
Query: 977 VELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLG 1036
+E+ +G SGLG+ ++ G T L A + I + AA DGRL GD+ILEVNG L
Sbjct: 1438 IEISKGRSGLGLSIVGGKDTPLNA--IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRN 1495
Query: 1037 LGYLRAVDLIRHGGKKMRFLVAKSD 1061
+ A+ +R +K+R +V + +
Sbjct: 1496 SSHEEAITALRQTPQKVRLVVYRDE 1520
Score = 50.4 bits (119), Expect = 9e-06
Identities = 25/85 (29%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
Query: 977 VELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLG 1036
+ELE+ +GLG+ L +++ + P PAAADGR+ +GD +LE+N L G
Sbjct: 1240 IELEKDKNGLGLSLAGNKDR--SRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYG 1297
Query: 1037 LGYLRAVDLIRHGGKKMRFLVAKSD 1061
+ A +I+ K++ + +++
Sbjct: 1298 RSHQNASAIIKTAPSKVKLVFIRNE 1322
Score = 49.3 bits (116), Expect = 2e-05
Identities = 39/140 (27%), Positives = 69/140 (49%), Gaps = 10/140 (7%)
Query: 926 CGKA---LPERQRNGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERG 982
CG + L R G + AP AL + P S SS E + VEL R
Sbjct: 316 CGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFE----TYNVELVRK 371
Query: 983 PS-GLGMGLIDGMHT-HLG-APGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGY 1039
LG+ ++ + T H G A G+Y+++++PGS A +G + + D+I+ V+G ++ G
Sbjct: 372 DGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFAN 431
Query: 1040 LRAVDLIRHGGKKMRFLVAK 1059
V+++R+ G+ + + +
Sbjct: 432 HDVVEVLRNAGQVVHLTLVR 451
Score = 44.7 bits (104), Expect = 5e-04
Identities = 28/88 (31%), Positives = 46/88 (52%), Gaps = 7/88 (7%)
Query: 977 VELERGPS-GLGMGLIDG------MHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEV 1029
VE+ R P+ LG+ ++ G + G++I+ +L SPA L GD+ILEV
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
Query: 1030 NGSSLLGLGYLRAVDLIRHGGKKMRFLV 1057
+G L + AV+ I++ G + F+V
Sbjct: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIV 1156
Score = 44.3 bits (103), Expect = 6e-04
Identities = 32/104 (30%), Positives = 57/104 (54%), Gaps = 4/104 (3%)
Query: 961 PSSRSSSTEDFCYVFTVELERGPS-GLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGR 1019
PS ++S T+ TVE+ R S LG+ + G + LG ++I + AA +
Sbjct: 1663 PSQKNSGTD--MEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQK 1720
Query: 1020 LSLGDRILEVNGSSLLGLGYLRAVDLIRHG-GKKMRFLVAKSDV 1062
L +GDRI+ +NG L GL + V+L+++ G+ + +VA +++
Sbjct: 1721 LKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
Score = 43.9 bits (102), Expect = 8e-04
Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 2/90 (2%)
Query: 977 VELER-GPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSL- 1034
+++ER GLG ++ +LG ++++ + PGS A D RL D+IL +N + L
Sbjct: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
Query: 1035 LGLGYLRAVDLIRHGGKKMRFLVAKSDVET 1064
+ + +A+ L++ +R +VA+ V T
Sbjct: 195 QNISHQQAIALLQQTTGSLRLIVAREPVHT 224
Score = 38.9 bits (89), Expect = 0.026
Identities = 22/67 (32%), Positives = 37/67 (55%), Gaps = 5/67 (7%)
Query: 969 EDFCYVFTVELERGPS-GLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRIL 1027
E+ +F V+L++ GLG+ ++ + G++I ++ G A DGRL GD+IL
Sbjct: 1526 EENLEIFPVDLQKKAGRGLGLSIVGKRN----GSGVFISDIVKGGAADLDGRLIQGDQIL 1581
Query: 1028 EVNGSSL 1034
VNG +
Sbjct: 1582 SVNGEDM 1588
Score = 32.7 bits (73), Expect = 1.9
Identities = 20/63 (31%), Positives = 28/63 (44%), Gaps = 8/63 (12%)
Query: 985 GLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVD 1044
G+ + DG H YI +++ G P G L D +LEVNG L G AV
Sbjct: 571 GVEVDSFDGHH--------YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVS 622
Query: 1045 LIR 1047
++
Sbjct: 623 FLK 625
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 60.1 bits (144), Expect = 1e-08
Identities = 32/92 (34%), Positives = 50/92 (54%), Gaps = 1/92 (1%)
Query: 985 GLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVD 1044
GLG ++ G + G G+Y++T+ G AAADGRL GD ILE+NG S+ GL + A+
Sbjct: 226 GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 285
Query: 1045 LIRHGGKKMRFLVAKSDVETAKKI-HFRTPPL 1075
+ K + L ++ + + +PPL
Sbjct: 286 KFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPL 317
Score = 51.2 bits (121), Expect = 5e-06
Identities = 34/100 (34%), Positives = 51/100 (51%), Gaps = 2/100 (2%)
Query: 949 DSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTL 1008
DS++ A ESP AP S + +++ E G GLG+GL + G+++ TL
Sbjct: 330 DSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGV-GLGIGLCSVPYFQC-ISGIFVHTL 387
Query: 1009 LPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRH 1048
PGS A DGRL GD I+E++ S + L ++ H
Sbjct: 388 SPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
Score = 41.6 bits (96), Expect = 0.004
Identities = 30/104 (28%), Positives = 50/104 (48%)
Query: 944 AAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGL 1003
A P+ +S+ + S A S S + V TV LE+ +GLG L G + G L
Sbjct: 1202 AMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPL 1261
Query: 1004 YIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIR 1047
I + G+ + + GD IL++ G+++ GL A ++I+
Sbjct: 1262 TINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
>gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens]
Length = 262
Score = 60.1 bits (144), Expect = 1e-08
Identities = 42/108 (38%), Positives = 57/108 (52%), Gaps = 9/108 (8%)
Query: 957 SPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAA 1016
S P PS S F+VEL RG +G G+ L G G L ++ LL PA
Sbjct: 46 SAPKPSQASGH-------FSVELVRGYAGFGLTLGGGRDV-AGDTPLAVRGLLKDGPAQR 97
Query: 1017 DGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVET 1064
GRL +GD +L +NG S GL + +AV+ IR GG ++ LV + +ET
Sbjct: 98 CGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLH-LVIRRPLET 144
>gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens]
Length = 334
Score = 60.1 bits (144), Expect = 1e-08
Identities = 42/108 (38%), Positives = 57/108 (52%), Gaps = 9/108 (8%)
Query: 957 SPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAA 1016
S P PS S F+VEL RG +G G+ L G P L ++ LL PA
Sbjct: 113 SAPKPSQASGH-------FSVELVRGYAGFGLTLGGGRDVAGDTP-LAVRGLLKDGPAQR 164
Query: 1017 DGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVET 1064
GRL +GD +L +NG S GL + +AV+ IR GG ++ LV + +ET
Sbjct: 165 CGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLH-LVIRRPLET 211
>gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
Length = 145
Score = 59.3 bits (142), Expect = 2e-08
Identities = 32/76 (42%), Positives = 42/76 (55%), Gaps = 2/76 (2%)
Query: 977 VELERGPSGLGMGLIDGMHTHLGA--PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSL 1034
+ L RGPSGLG ++ G + G+Y+ + AA DGRL GD+IL VNG L
Sbjct: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
Query: 1035 LGLGYLRAVDLIRHGG 1050
L + AVDL R+ G
Sbjct: 74 KNLLHQDAVDLFRNAG 89
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 59.3 bits (142), Expect = 2e-08
Identities = 32/85 (37%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 977 VELERGPSGLGMGLIDGM-HTHLGA-PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSL 1034
+ LERG SGLG + G + H+G PG++I ++PG AA DGRL + D IL VN +
Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
Query: 1035 LGLGYLRAVDLIRHGGKKMRFLVAK 1059
+ + +AV+ ++ G +R V +
Sbjct: 108 SEVSHSKAVEALKEAGSIVRLYVRR 132
Score = 51.2 bits (121), Expect = 5e-06
Identities = 29/88 (32%), Positives = 50/88 (56%), Gaps = 2/88 (2%)
Query: 974 VFTVELERGPSGLGMGLIDGM-HTHL-GAPGLYIQTLLPGSPAAADGRLSLGDRILEVNG 1031
V ++L +GP GLG + G+ + H+ G +Y+ ++ G A DGRL +GDR+L VN
Sbjct: 140 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 199
Query: 1032 SSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
SL + + AV ++++ + + V K
Sbjct: 200 YSLEEVTHEEAVAILKNTSEVVYLKVGK 227
Score = 49.3 bits (116), Expect = 2e-05
Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 7/96 (7%)
Query: 977 VELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLG 1036
V L +G +GLG ++ G G+++ +L G PA G L GD+IL VNG L G
Sbjct: 319 VVLHKGSTGLGFNIVGGED----GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 374
Query: 1037 LGYLRAVDLIRHGGKKMRFLVAKSDVETAK---KIH 1069
+ +A ++ G+ + + + A+ KIH
Sbjct: 375 ASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 410
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 59.3 bits (142), Expect = 2e-08
Identities = 32/85 (37%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 977 VELERGPSGLGMGLIDGM-HTHLGA-PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSL 1034
+ LERG SGLG + G + H+G PG++I ++PG AA DGRL + D IL VN +
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
Query: 1035 LGLGYLRAVDLIRHGGKKMRFLVAK 1059
+ + +AV+ ++ G +R V +
Sbjct: 264 SEVSHSKAVEALKEAGSIVRLYVRR 288
Score = 51.2 bits (121), Expect = 5e-06
Identities = 29/88 (32%), Positives = 50/88 (56%), Gaps = 2/88 (2%)
Query: 974 VFTVELERGPSGLGMGLIDGM-HTHL-GAPGLYIQTLLPGSPAAADGRLSLGDRILEVNG 1031
V ++L +GP GLG + G+ + H+ G +Y+ ++ G A DGRL +GDR+L VN
Sbjct: 296 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 355
Query: 1032 SSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
SL + + AV ++++ + + V K
Sbjct: 356 YSLEEVTHEEAVAILKNTSEVVYLKVGK 383
Score = 49.3 bits (116), Expect = 2e-05
Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 7/96 (7%)
Query: 977 VELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLG 1036
V L +G +GLG ++ G G+++ +L G PA G L GD+IL VNG L G
Sbjct: 527 VVLHKGSTGLGFNIVGGED----GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 582
Query: 1037 LGYLRAVDLIRHGGKKMRFLVAKSDVETAK---KIH 1069
+ +A ++ G+ + + + A+ KIH
Sbjct: 583 ASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 618
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 59.3 bits (142), Expect = 2e-08
Identities = 32/85 (37%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 977 VELERGPSGLGMGLIDGM-HTHLGA-PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSL 1034
+ LERG SGLG + G + H+G PG++I ++PG AA DGRL + D IL VN +
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 1035 LGLGYLRAVDLIRHGGKKMRFLVAK 1059
+ + +AV+ ++ G +R V +
Sbjct: 159 SEVSHSKAVEALKEAGSIVRLYVRR 183
Score = 51.2 bits (121), Expect = 5e-06
Identities = 29/88 (32%), Positives = 50/88 (56%), Gaps = 2/88 (2%)
Query: 974 VFTVELERGPSGLGMGLIDGM-HTHL-GAPGLYIQTLLPGSPAAADGRLSLGDRILEVNG 1031
V ++L +GP GLG + G+ + H+ G +Y+ ++ G A DGRL +GDR+L VN
Sbjct: 191 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 250
Query: 1032 SSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
SL + + AV ++++ + + V K
Sbjct: 251 YSLEEVTHEEAVAILKNTSEVVYLKVGK 278
Score = 49.3 bits (116), Expect = 2e-05
Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 7/96 (7%)
Query: 977 VELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLG 1036
V L +G +GLG ++ G G+++ +L G PA G L GD+IL VNG L G
Sbjct: 422 VVLHKGSTGLGFNIVGGED----GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 477
Query: 1037 LGYLRAVDLIRHGGKKMRFLVAKSDVETAK---KIH 1069
+ +A ++ G+ + + + A+ KIH
Sbjct: 478 ASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 513
>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 3 [Homo
sapiens]
Length = 1612
Score = 58.9 bits (141), Expect = 2e-08
Identities = 86/398 (21%), Positives = 153/398 (38%), Gaps = 69/398 (17%)
Query: 407 LEFEPHLEDTLLQRIMTLIEPGGDDHKLTPAFLLCLCIQHSATH-FQPGTFGQLLLKIAR 465
+EF ED+ L I+ KL+P ++L + ++ ++ ++P +
Sbjct: 589 IEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPD------ISPTE 642
Query: 466 LIRETVWEKTKELAEKQAQLQEPISLASCAMADLVPDLQPILFWMSNSIELLYFIQQKCP 525
+ + K ++ + +Q+ ++A + FWM+N+ ELL FI+Q
Sbjct: 643 RTHKVIAVVNKMVSMMEGVIQKQKNIAGA-----------LAFWMANASELLNFIKQD-- 689
Query: 526 LYMQSMEEQLDITGSKESLFSCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSLYICLPAL 585
L TL A + VL +V AF+ V+ + L +PA
Sbjct: 690 ----------------RDLSRITLDAQD----VLAHLVQMAFKYLVHCLQSELNNYMPAF 729
Query: 586 LECPPFQTERRESWSSAPELPEELRRVVSVYQAALDLLRQLQVHPEVASQMLAYLFFFSG 645
L+ P + +R P++ + L + A+ LLR+ +V+ + Q+ + LF F
Sbjct: 730 LDDPEENSLQR------PKIDDVLHTLTG----AMSLLRRCRVNAALTIQLFSQLFHFIN 779
Query: 646 TLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNLLA 705
L N+L+ S C H+ G +L + W G A + ++ LL
Sbjct: 780 MWLFNRLVTDPDSGLCSHY-WGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLT 838
Query: 706 TPR---AQLIQMSWTALRAAFPALSPAQLHRLLTHYQLA--SAMGPMSTWE----PGAQD 756
+ + ++ T + L+ QL LL +Y A P E
Sbjct: 839 MDKYAPDDIPNINSTCFK-----LNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENT 893
Query: 757 SPEAFRSEDVLESYENPP----PIVLPSDGFQVDLEAN 790
+ E RS+ E P P +LP DG+ D+ N
Sbjct: 894 ADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRN 931
Score = 53.5 bits (127), Expect = 1e-06
Identities = 28/86 (32%), Positives = 50/86 (58%), Gaps = 1/86 (1%)
Query: 974 VFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSS 1033
+ TV L++ +G+G+ ++ G+Y+++++ G A DGRL+ GD++L V+G S
Sbjct: 991 IITVTLKK-QNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1049
Query: 1034 LLGLGYLRAVDLIRHGGKKMRFLVAK 1059
L+GL RA +L+ + VAK
Sbjct: 1050 LVGLSQERAAELMTRTSSVVTLEVAK 1075
Score = 44.3 bits (103), Expect = 6e-04
Identities = 29/100 (29%), Positives = 47/100 (47%), Gaps = 1/100 (1%)
Query: 63 GVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAGDA 122
G L+++ DS+ YK++L + T A V EALE+Y L+ Y + V+ G
Sbjct: 247 GTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVMLPPGAQ 306
Query: 123 GQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKR 162
+ + D E PL I W +G+ F+L++R
Sbjct: 307 HSDEKGAKEIILDDDECPLQIFREWPSDKGI-LVFQLKRR 345
>gi|215982794 myosin VA isoform 2 [Homo sapiens]
Length = 1828
Score = 58.9 bits (141), Expect = 2e-08
Identities = 67/307 (21%), Positives = 130/307 (42%), Gaps = 48/307 (15%)
Query: 399 LPRRQ---QLLLEFEPHLEDTLLQRIMTLIEPGGDDHKLTP---AFLLCLCIQHSATHFQ 452
+PR++ Q +LE++ E L++ ++ ++P G L P A++L +C++H A +
Sbjct: 1439 IPRKEKDFQGMLEYKKEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRH-ADYLN 1497
Query: 453 PGTFGQLLLKIARLIRETVWEKTKELAEKQAQLQEPISLASCAMADLVPDLQPILFWMSN 512
K+ L+ T+ K++ +K+ D + + FW+SN
Sbjct: 1498 DDQ------KVRSLLTSTI-NSIKKVLKKRGD-----------------DFETVSFWLSN 1533
Query: 513 SIELLYFIQQKCPLYMQSMEEQLDITGSKESLFSCTLTASEEAMAVLEEVVLYAFQQCVY 572
+ L+ ++Q E + S+++ T E VL ++ + +QQ V
Sbjct: 1534 TCRFLHCLKQ-----YSGEEGFMKHNTSRQNEHCLTNFDLAEYRQVLSDLAIQIYQQLVR 1588
Query: 573 YVSKSLY-ICLPALLECPPFQTE--------RRESWSSAPELPEELRRVVSVYQAALDLL 623
+ L + + +LE Q R+ + S A E L ++ + ++
Sbjct: 1589 VLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSILRQLNSFHSVM 1648
Query: 624 RQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWMRS 683
Q + PE+ Q++ +F+ G + LN LL R S W +G+Q + QL EW+R
Sbjct: 1649 CQHGMDPELIKQVVKQMFYIIGAITLNNLLLRKDMCS---WSKGMQIRYNVSQLEEWLRD 1705
Query: 684 AGFGAAG 690
+G
Sbjct: 1706 KNLMNSG 1712
>gi|215982791 myosin VA isoform 1 [Homo sapiens]
Length = 1855
Score = 58.9 bits (141), Expect = 2e-08
Identities = 67/307 (21%), Positives = 130/307 (42%), Gaps = 48/307 (15%)
Query: 399 LPRRQ---QLLLEFEPHLEDTLLQRIMTLIEPGGDDHKLTP---AFLLCLCIQHSATHFQ 452
+PR++ Q +LE++ E L++ ++ ++P G L P A++L +C++H A +
Sbjct: 1466 IPRKEKDFQGMLEYKKEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRH-ADYLN 1524
Query: 453 PGTFGQLLLKIARLIRETVWEKTKELAEKQAQLQEPISLASCAMADLVPDLQPILFWMSN 512
K+ L+ T+ K++ +K+ D + + FW+SN
Sbjct: 1525 DDQ------KVRSLLTSTI-NSIKKVLKKRGD-----------------DFETVSFWLSN 1560
Query: 513 SIELLYFIQQKCPLYMQSMEEQLDITGSKESLFSCTLTASEEAMAVLEEVVLYAFQQCVY 572
+ L+ ++Q E + S+++ T E VL ++ + +QQ V
Sbjct: 1561 TCRFLHCLKQ-----YSGEEGFMKHNTSRQNEHCLTNFDLAEYRQVLSDLAIQIYQQLVR 1615
Query: 573 YVSKSLY-ICLPALLECPPFQTE--------RRESWSSAPELPEELRRVVSVYQAALDLL 623
+ L + + +LE Q R+ + S A E L ++ + ++
Sbjct: 1616 VLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSILRQLNSFHSVM 1675
Query: 624 RQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWMRS 683
Q + PE+ Q++ +F+ G + LN LL R S W +G+Q + QL EW+R
Sbjct: 1676 CQHGMDPELIKQVVKQMFYIIGAITLNNLLLRKDMCS---WSKGMQIRYNVSQLEEWLRD 1732
Query: 684 AGFGAAG 690
+G
Sbjct: 1733 KNLMNSG 1739
>gi|140972063 protein phosphatase 1, regulatory subunit 9B [Homo
sapiens]
Length = 817
Score = 57.8 bits (138), Expect = 5e-08
Identities = 63/250 (25%), Positives = 98/250 (39%), Gaps = 45/250 (18%)
Query: 846 APSCPLAPRDPGPAAREVAPERTLPLRGAPWAQAPP------GRQPSRGGSQAGPPHTDS 899
AP P A P A VAP P RG +AP S+A +
Sbjct: 342 APEEPKAQAAPEKEAAAVAP----PERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSA 397
Query: 900 SCLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAE---E 956
L S E D D E G P P +G + G + E D A +
Sbjct: 398 YSGLGEDSAGSALEEDDEDDEEDGEP-----PYEPESGCVEIPGLSEEEDPAPSRKIHFS 452
Query: 957 SPPAPSSRSSSTEDF------------------------CYVFTVELERGPSGLGMGLID 992
+ P + S ED+ +F VELE+ GLG+ +I
Sbjct: 453 TAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVELEKDSEGLGISIIG 512
Query: 993 ---GMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHG 1049
G L G++++T+ G A DGR+ + D ++EV+G+SL+G+ A ++R+
Sbjct: 513 MGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNT 572
Query: 1050 GKKMRFLVAK 1059
++RF++ +
Sbjct: 573 KGRVRFMIGR 582
>gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens]
Length = 817
Score = 57.4 bits (137), Expect = 7e-08
Identities = 31/85 (36%), Positives = 51/85 (60%), Gaps = 2/85 (2%)
Query: 977 VELERGPSGLGMGLIDGM-HTHL-GAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSL 1034
+ LERG SGLG + G+ + H+ PG++I ++PG AA DGRL + D +L VN +
Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
Query: 1035 LGLGYLRAVDLIRHGGKKMRFLVAK 1059
+ + RAV+ ++ G +R +V +
Sbjct: 192 SEVVHSRAVEALKEAGPVVRLVVRR 216
Score = 52.8 bits (125), Expect = 2e-06
Identities = 30/88 (34%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Query: 974 VFTVELERGPSGLGMGLIDGM-HTHL-GAPGLYIQTLLPGSPAAADGRLSLGDRILEVNG 1031
+ V L +GP GLG + G+ + H+ G +YI ++ G A DGRL +GDR+L VN
Sbjct: 224 IMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283
Query: 1032 SSLLGLGYLRAVDLIRHGGKKMRFLVAK 1059
++L + + AV +++ + VAK
Sbjct: 284 TNLQDVRHEEAVASLKNTSDMVYLKVAK 311
Score = 47.4 bits (111), Expect = 7e-05
Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 7/94 (7%)
Query: 979 LERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLG 1038
L +G +GLG ++ G G+++ +L G PA G L GDRIL VNG +L
Sbjct: 389 LHKGSTGLGFNIVGGED----GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444
Query: 1039 YLRAVDLIRHGGKKMRFLVAKSDVETAK---KIH 1069
+ +A ++ G+ + + E ++ KIH
Sbjct: 445 HEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIH 478
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,963,459
Number of Sequences: 37866
Number of extensions: 2740425
Number of successful extensions: 14770
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 127
Number of HSP's successfully gapped in prelim test: 756
Number of HSP's that attempted gapping in prelim test: 11786
Number of HSP's gapped (non-prelim): 3099
length of query: 1075
length of database: 18,247,518
effective HSP length: 113
effective length of query: 962
effective length of database: 13,968,660
effective search space: 13437850920
effective search space used: 13437850920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.