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Search of human proteins with 148539593
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148539593 sushi domain containing 4 isoform a [Homo sapiens]
(490 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148539593 sushi domain containing 4 isoform a [Homo sapiens] 1040 0.0
gi|81295416 sushi domain containing 4 isoform b [Homo sapiens] 518 e-147
gi|7662020 hypothetical protein LOC9766 [Homo sapiens] 132 7e-31
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 95 2e-19
gi|148886654 polydom [Homo sapiens] 94 3e-19
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 89 1e-17
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 89 1e-17
gi|110611237 coagulation factor XIII B subunit precursor [Homo s... 86 1e-16
gi|157419154 selectin P precursor [Homo sapiens] 82 1e-15
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 78 2e-14
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 77 5e-14
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 75 1e-13
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 75 1e-13
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 75 2e-13
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 74 4e-13
gi|187960042 selectin E precursor [Homo sapiens] 73 7e-13
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 72 9e-13
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 72 9e-13
gi|13540563 complement factor H-related 5 [Homo sapiens] 72 1e-12
gi|4502503 complement component 4 binding protein, alpha chain p... 70 6e-12
gi|54792787 complement factor H-related 3 [Homo sapiens] 69 1e-11
gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3 ... 67 4e-11
gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2 ... 67 4e-11
gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4 ... 66 8e-11
gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [H... 66 8e-11
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 64 2e-10
gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens] 58 2e-08
gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens] 58 2e-08
gi|118442839 complement factor H-related 1 [Homo sapiens] 57 5e-08
gi|239758113 PREDICTED: similar to complement factor H-related 1... 57 5e-08
>gi|148539593 sushi domain containing 4 isoform a [Homo sapiens]
Length = 490
Score = 1040 bits (2688), Expect = 0.0
Identities = 490/490 (100%), Positives = 490/490 (100%)
Query: 1 MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP 60
MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP
Sbjct: 1 MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP 60
Query: 61 GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE 120
GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE
Sbjct: 61 GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE 120
Query: 121 DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC 180
DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC
Sbjct: 121 DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC 180
Query: 181 LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL
Sbjct: 181 LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
Query: 241 EVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQV 300
EVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQV
Sbjct: 241 EVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQV 300
Query: 301 YCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSS 360
YCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSS
Sbjct: 301 YCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSS 360
Query: 361 SSDPDFVVVDGVPVMLPSYDEAVSGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDT 420
SSDPDFVVVDGVPVMLPSYDEAVSGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDT
Sbjct: 361 SSDPDFVVVDGVPVMLPSYDEAVSGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDT 420
Query: 421 DTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVASTSPGIDIA 480
DTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVASTSPGIDIA
Sbjct: 421 DTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVASTSPGIDIA 480
Query: 481 DEIPLMEEDP 490
DEIPLMEEDP
Sbjct: 481 DEIPLMEEDP 490
>gi|81295416 sushi domain containing 4 isoform b [Homo sapiens]
Length = 290
Score = 518 bits (1333), Expect = e-147
Identities = 241/241 (100%), Positives = 241/241 (100%)
Query: 1 MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP 60
MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP
Sbjct: 1 MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP 60
Query: 61 GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE 120
GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE
Sbjct: 61 GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE 120
Query: 121 DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC 180
DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC
Sbjct: 121 DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC 180
Query: 181 LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL
Sbjct: 181 LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
Query: 241 E 241
E
Sbjct: 241 E 241
>gi|7662020 hypothetical protein LOC9766 [Homo sapiens]
Length = 303
Score = 132 bits (332), Expect = 7e-31
Identities = 82/204 (40%), Positives = 113/204 (55%), Gaps = 16/204 (7%)
Query: 242 VCPLPPMVSHGDFVCHPRPC-ERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQV 300
VCPLPP +G ++CHPRPC + G+V+E+ C GY L DYKY+TC+ GEW P+ ++
Sbjct: 41 VCPLPPEPENGGYICHPRPCRDPLTAGSVIEYLCAEGYMLKGDYKYLTCKNGEWKPAMEI 100
Query: 301 YCIKSEQTWPSTHETL-LTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRS 359
C +E TH +L + T IVA TA+SV L+LLLV+L + Q K K+ R +
Sbjct: 101 SCRLNED--KDTHTSLGVPTLSIVASTASSVALILLLVVLFVLLQPKLKSFHHSR-RDQG 157
Query: 360 SSSDPDFVVVDGVPVMLPSYDEAVSGGLSALGP------GYMASVG---QGCPLPVDDQS 410
S D ++VDGV V LPSY+EAV G P + S G G +P + Q
Sbjct: 158 VSGDQVSIMVDGVQVALPSYEEAVYGSSGHCVPPADPRVQIVLSEGSGPSGRSVPREQQL 217
Query: 411 PP--AYPGSGDTDTGPGESETCDS 432
P A +G D PG+S C++
Sbjct: 218 PDQGACSSAGGEDEAPGQSGLCEA 241
Score = 31.6 bits (70), Expect = 1.7
Identities = 26/78 (33%), Positives = 35/78 (44%), Gaps = 13/78 (16%)
Query: 56 VCADPGIPENG----FRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIP 111
VC P PENG P GSV + C +G+ LKG K L K NG W P
Sbjct: 41 VCPLPPEPENGGYICHPRPCRDPLTAGSVIEYLCAEGYMLKGDYKYLTCK--NGE--WKP 96
Query: 112 SDNSICVQEDCRIPQIED 129
+ ++ CR+ + +D
Sbjct: 97 A-----MEISCRLNEDKD 109
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 94.7 bits (234), Expect = 2e-19
Identities = 75/245 (30%), Positives = 111/245 (45%), Gaps = 22/245 (8%)
Query: 57 CADPGIPENGFR-TPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
C+ P P +G+ + +GG SV R+ C GF+L G + +C K G W +
Sbjct: 2465 CSTPESPPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW-DAPVP 2521
Query: 116 ICVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C IP+ + I Y G ++ C++G+++ +L V C+ DGTW+N
Sbjct: 2522 ACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAV--CQSDGTWSNH 2579
Query: 174 --LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
P C C NG N QTS+ G+ + C GF L GSA ECL + +
Sbjct: 2580 NKTPRCVVISCGELPTPPNG--NKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGL 2635
Query: 230 WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITC 289
WS S RCLA C +P ++ +G + E Y + V + C+PG+ L I
Sbjct: 2636 WSESETRCLAGH-CGIPELIVNGQVI-----GENYGYRDTVVYQCNPGFRLIGSSVRICQ 2689
Query: 290 QYGEW 294
Q W
Sbjct: 2690 QDHNW 2694
Score = 88.6 bits (218), Expect = 1e-17
Identities = 75/253 (29%), Positives = 104/253 (41%), Gaps = 34/253 (13%)
Query: 52 DDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIP 111
D C DPG P +G R S F S R+ C G+ L G+ +R CL + + T G P
Sbjct: 2882 DATGTCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWT-GRQP 2938
Query: 112 SDNSICVQEDCRIPQIEDAEIHNKTYR-----HGEKLIITCHEGFKIRYPDLHNMVSLCR 166
C C P + K +R +I +C EG+ + P V C
Sbjct: 2939 E----CKAVQCGNP---GTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPS----VRQCT 2987
Query: 167 DDGTWN-NLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGF--KLDGSAY 221
+GTW+ LP C C P +NG + VG +SY C PG+ +L+GS
Sbjct: 2988 ANGTWSGTLPNCTIISCGDPGIPANGL----RYGDDYVVGQNVSYMCQPGYTMELNGSRI 3043
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLT 281
C N WS P C A+ CP PP +S+G ++ G + + C PGY L+
Sbjct: 3044 RTCTINGTWSGVMPTCRAV-TCPTPPQISNGRL-----EGTNFDWGFSISYICSPGYELS 3097
Query: 282 SDYKYITCQYGEW 294
G W
Sbjct: 3098 FPAVLTCVGNGTW 3110
Score = 79.7 bits (195), Expect = 5e-15
Identities = 74/257 (28%), Positives = 110/257 (42%), Gaps = 25/257 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTL-GWIPSDNS 115
C +PG NG G F SV + C +G+ L G + R C NGT G +P+
Sbjct: 2945 CGNPGTTANGKVFRIDGTTFSSSVI-YSCMEGYILSGPSVRQCTA--NGTWSGTLPN--- 2998
Query: 116 ICVQEDCRIPQIEDAEI-HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C P I + + Y G+ + C G+ + + + C +GTW+
Sbjct: 2999 -CTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNG--SRIRTCTINGTWSGV 3055
Query: 174 LPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
+P C+ C P SNG + T+F G ISY C PG++L A L C+ N WS
Sbjct: 3056 MPTCRAVTCPTPPQISNGRLE----GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3111
Query: 232 SSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQY 291
P+CL + C P + + G R + + + + V F C+ + L I
Sbjct: 3112 GEVPQCLP-KFCGDPGIPAQG-----KREGKSFIYQSEVSFSCNFPFILVGSSTRICQAD 3165
Query: 292 GEWFPSYQVYCIKSEQT 308
G W S +CI+ QT
Sbjct: 3166 GTWSGS-SPHCIEPTQT 3181
Score = 70.5 bits (171), Expect = 3e-12
Identities = 69/297 (23%), Positives = 104/297 (35%), Gaps = 78/297 (26%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGF--KLKGATKRLCLKHFNGTL-GWIPSD 113
C DPGIP NG R G + G + CQ G+ +L G+ R C NGT G +P+
Sbjct: 3004 CGDPGIPANGLRY--GDDYVVGQNVSYMCQPGYTMELNGSRIRTCT--INGTWSGVMPTC 3059
Query: 114 NSICVQEDCRIPQIEDAEIHNKTY------------------------------------ 137
++ PQI + + +
Sbjct: 3060 RAVTCPTP---PQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQ 3116
Query: 138 ----------------RHGEKLIITCHEGFKIRYPDL--HNMVSLCRDDGTWNNL----- 174
R G+ I F +P + + +C+ DGTW+
Sbjct: 3117 CLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCI 3176
Query: 175 -PICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSS 233
P C P +G N + F VG+V+ + C G L GS CL +L WS
Sbjct: 3177 EPTQTSCENPGVPRHGSQNNT---FGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGI 3233
Query: 234 PPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
P C+ C P +H + V P +HG + + C PG+ L ++ C+
Sbjct: 3234 QPECIP-HSCKQPETPAHANVVGMDLP----SHGYTLIYTCQPGFFLAGGTEHRVCR 3285
Score = 67.4 bits (163), Expect = 3e-11
Identities = 59/227 (25%), Positives = 100/227 (44%), Gaps = 26/227 (11%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHG-- 140
+ C GF+L G++ R+C + N + G +PS CV C P + I+ +T +G
Sbjct: 2672 YQCNPGFRLIGSSVRICQQDHNWS-GQLPS----CVPVSCGHP---GSPIYGRTSGNGFN 2723
Query: 141 --EKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ--GCLRPLASSNGYVNISE 195
+ + +C+ G+ ++ P + C+ + W++ P +C+ C P +N
Sbjct: 2724 FNDVVTFSCNIGYLMQGPTK----AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKI 2779
Query: 196 LQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFV 255
+F GTV+ Y C PG+ L GS+ L C N W P C+ ++ C P + +
Sbjct: 2780 EHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMID-CGHPGVPPNAVL- 2837
Query: 256 CHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYC 302
E+Y G+ V + C SL TCQ + Q +C
Sbjct: 2838 ----SGEKYTFGSTVHYSCTGKRSLLGQSSR-TCQLNGHWSGSQPHC 2879
Score = 62.8 bits (151), Expect = 7e-10
Identities = 54/205 (26%), Positives = 86/205 (41%), Gaps = 23/205 (11%)
Query: 57 CADPGIPENGFRTPS--GGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN 114
C+DPGIP N R G F G+V + C G+ L G++ +C + G
Sbjct: 2764 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN-----GQWDKPL 2818
Query: 115 SICVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN- 172
C+ DC P + +A + + Y G + +C + L C+ +G W+
Sbjct: 2819 PECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL----LGQSSRTCQLNGHWSG 2874
Query: 173 NLPICQG-----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
+ P C G C P +G S +++F + + Y C G+ L GS CL N
Sbjct: 2875 SQPHCSGDATGTCGDPGTPGHG----SRQESNFRTKSTVRYACDTGYILHGSEERTCLAN 2930
Query: 228 LIWSSSPPRCLALEVCPLPPMVSHG 252
W+ P C A++ C P ++G
Sbjct: 2931 GSWTGRQPECKAVQ-CGNPGTTANG 2954
Score = 56.6 bits (135), Expect = 5e-08
Identities = 57/234 (24%), Positives = 89/234 (38%), Gaps = 23/234 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + + G+ + C DG++L + +GT W + +
Sbjct: 2528 CGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT--WSNHNKTP 2583
Query: 117 -CVQEDC-RIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
CV C +P + +G I TC GF + + + V C G W+
Sbjct: 2584 RCVVISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFML----VGSAVRECLSSGLWSES 2639
Query: 175 P---ICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
+ C P NG V + ++ + Y+C PGF+L GS+ C Q+ WS
Sbjct: 2640 ETRCLAGHCGIPELIVNGQV----IGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWS 2695
Query: 232 SSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYK 285
P C+ + C P G + +N VV F C+ GY + K
Sbjct: 2696 GQLPSCVPVS-CGHP-----GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTK 2743
Score = 47.4 bits (111), Expect = 3e-05
Identities = 26/65 (40%), Positives = 34/65 (52%), Gaps = 6/65 (9%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPP 235
Q C P NG+V + F VG IS+ CFPG+ L G++ L CL + W+ P
Sbjct: 2118 QSCPDPRPFRNGFV----IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLP 2173
Query: 236 RCLAL 240
RC AL
Sbjct: 2174 RCEAL 2178
Score = 41.2 bits (95), Expect = 0.002
Identities = 64/248 (25%), Positives = 87/248 (35%), Gaps = 50/248 (20%)
Query: 62 IPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW-------IPSDN 114
+PE F G F GS F C G+ L G+ C N W I
Sbjct: 1777 VPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1836
Query: 115 SICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIR---YPDLHNMVSLCRDDGTW 171
I + I E ++ K+ + G +++ + HN SL DG
Sbjct: 1837 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGD 1896
Query: 172 NNLPIC---QGCLRP----LASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
NN P G P S+N Y+N Q+ V GF L+ +A
Sbjct: 1897 NNAPRLGSYSGTTIPHLLNSTSNNLYLNF---QSDISVSAA-------GFHLEYTA---- 1942
Query: 225 LQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDY 284
+ L+ CP P S G + +RY G VV F CD GYSL +
Sbjct: 1943 -------------IGLDSCPEPQTPSSGIKIG-----DRYMVGDVVSFQCDQGYSL-QGH 1983
Query: 285 KYITCQYG 292
+ITC G
Sbjct: 1984 SHITCMPG 1991
Score = 40.0 bits (92), Expect = 0.005
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 2/48 (4%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L+ C DPGIP+ G R G F G F C G++L+G ++ +CL
Sbjct: 1074 NLEPCEDPGIPQYGSRI--GFNFGIGDTLTFSCSSGYRLEGTSEIICL 1119
Score = 39.3 bits (90), Expect = 0.008
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLALEVCP 244
F +G +I Y+C PGF L G+A L C + L +PP C L CP
Sbjct: 2309 FEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL--CP 2353
Score = 38.9 bits (89), Expect = 0.011
Identities = 22/67 (32%), Positives = 30/67 (44%), Gaps = 3/67 (4%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C DPG PENG R G F GS +F C + + L+GA C + W
Sbjct: 381 LCPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAW-SDHRP 437
Query: 116 ICVQEDC 122
+C + C
Sbjct: 438 VCKVKTC 444
Score = 37.7 bits (86), Expect = 0.024
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 4/62 (6%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPG+P NG R G G F C G++L+G + C++ N W PS +
Sbjct: 1424 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYF-WQPSP-PV 1479
Query: 117 CV 118
C+
Sbjct: 1480 CI 1481
Score = 37.4 bits (85), Expect = 0.031
Identities = 19/50 (38%), Positives = 23/50 (46%), Gaps = 4/50 (8%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WSSSPPRCLALEVC 243
T F VG I Y C G+ LDG L C+ N + W P C A + C
Sbjct: 192 TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDAC 241
Score = 37.4 bits (85), Expect = 0.031
Identities = 15/48 (31%), Positives = 30/48 (62%), Gaps = 2/48 (4%)
Query: 194 SELQTSFPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA 239
S + +F +G +++ C G++L+G++ + CL +WS+ PRC+A
Sbjct: 1088 SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1135
Score = 37.0 bits (84), Expect = 0.041
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L C DPGIP+ G++ G F GS + C G+ L G++ C+
Sbjct: 1246 ELSHCEDPGIPQFGYKISDQG-HFAGSTIIYGCNPGYTLHGSSLLKCM 1292
Score = 36.6 bits (83), Expect = 0.053
Identities = 52/238 (21%), Positives = 84/238 (35%), Gaps = 58/238 (24%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPG NG R G + GS ++C G+ L+G + C+ +G GW +PS
Sbjct: 1597 CFDPGNIMNGTRL--GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1654
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLI--------ITCHEGFKIRYPDLHNMV--- 162
++ C + + K Y G + F LH++V
Sbjct: 1655 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVY 1714
Query: 163 ----------SLCRDDGTWNNLPICQG---CLR-------------------PLASSNGY 190
S + +LP+ G +R P SS
Sbjct: 1715 DGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQC 1774
Query: 191 VNISE------LQTSFPVGTVISYRCFPGFKLDGSAYLEC--LQNLI--WSSSPPRCL 238
++ E + F VG+ + + C PG+ L GS + C + N + W+ S P C+
Sbjct: 1775 SSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1832
Score = 36.2 bits (82), Expect = 0.070
Identities = 19/43 (44%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLC 99
C DPG P G R G F V RF CQ GF+L G +C
Sbjct: 560 CGDPGTPLYGIREGDG--FSNRDVLRFECQFGFELIGEKSIVC 600
Score = 36.2 bits (82), Expect = 0.070
Identities = 14/40 (35%), Positives = 22/40 (55%), Gaps = 3/40 (7%)
Query: 203 GTVISYRCFPGFKLDGSAYLECLQ---NLIWSSSPPRCLA 239
G + ++C PG++L G + C+Q W SPP C+A
Sbjct: 1443 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1482
Score = 35.4 bits (80), Expect = 0.12
Identities = 18/62 (29%), Positives = 32/62 (51%), Gaps = 6/62 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPPRC 237
C P S+G ++ + VG V+S++C G+ L G +++ C+ + W+ P C
Sbjct: 1948 CPEPQTPSSGI----KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2003
Query: 238 LA 239
LA
Sbjct: 2004 LA 2005
Score = 35.0 bits (79), Expect = 0.15
Identities = 19/46 (41%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKH 102
C DPGIP +G R G F GS F C G++L LC K+
Sbjct: 906 CLDPGIPVHGRRY--GHDFSIGSTVSFSCDSGYRLSHEEPLLCEKN 949
Score = 35.0 bits (79), Expect = 0.15
Identities = 67/287 (23%), Positives = 97/287 (33%), Gaps = 69/287 (24%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
LQ C DP NGF G F G F C G+ L G + CL
Sbjct: 2117 LQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGNSALTCL------------- 2161
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN 173
+ + + +P+ E N T +G G+ YP+ + L R
Sbjct: 2162 HGVSRNWNHPLPRCEALCGGNITAMNGT----IYSPGYPDEYPNFQDCFWLVR------- 2210
Query: 174 LPICQGCLRPLASSNG-YVNISELQTSFPVGTVISY-----------RCFPGFKLDGSAY 221
+ NG Y+N + LQT P+ I+ F G S Y
Sbjct: 2211 ----------VPPGNGIYINFTVLQTE-PIYDFITVWDGPDQNSPQIGQFSGNTALESVY 2259
Query: 222 LECLQNLIWSSSP----------PRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVE 271
Q LI S L VC PP V + + + + + G ++
Sbjct: 2260 STSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTED---DEFEIGDIIR 2316
Query: 272 FYCDPGYSLTSDYKYITCQYGEWF------PSYQVYCIKSEQTWPST 312
+ C PG++L + +TC+ GE P QV C +E ST
Sbjct: 2317 YQCLPGFTLVGN-AILTCRLGERLQMDGAPPVCQVLCPANELRLDST 2362
Score = 33.9 bits (76), Expect = 0.34
Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 2/39 (5%)
Query: 203 GTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA 239
G+ I Y C PG+ L GS+ L+C+ + W P C+A
Sbjct: 1270 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1308
Score = 33.5 bits (75), Expect = 0.45
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
F +G+ +S+ C G++L L C +N WS P C AL
Sbjct: 922 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 962
Score = 32.0 bits (71), Expect = 1.3
Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 21/89 (23%)
Query: 150 GFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYR 209
GFK+ Y ++ C D GT L + +G+ N V+ +
Sbjct: 547 GFKVNYKEIEK--ESCGDPGT---------PLYGIREGDGFSNRD----------VLRFE 585
Query: 210 CFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
C GF+L G + C +N WS++ P C+
Sbjct: 586 CQFGFELIGEKSIVCQENNQWSANIPICI 614
Score = 31.6 bits (70), Expect = 1.7
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
L C +P P +G + G + G V F C G+ L+G + C+
Sbjct: 1945 LDSCPEPQTPSSGIKI--GDRYMVGDVVSFQCDQGYSLQGHSHITCM 1989
Score = 29.6 bits (65), Expect = 6.5
Identities = 13/30 (43%), Positives = 17/30 (56%), Gaps = 1/30 (3%)
Query: 264 YNHGTVVEFYCDPGYSLTSDYKYITCQYGE 293
Y G+ V +YCD GY L Y +TC G+
Sbjct: 1613 YKLGSTVTYYCDAGYVL-QGYSTLTCIMGD 1641
Score = 29.3 bits (64), Expect = 8.5
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 5/64 (7%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPGIP N R G F GS C++GF T+ + +G + W IP
Sbjct: 730 CPDPGIPINARR--FGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 787
Query: 114 NSIC 117
+ C
Sbjct: 788 GAPC 791
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 94.0 bits (232), Expect = 3e-19
Identities = 74/264 (28%), Positives = 112/264 (42%), Gaps = 23/264 (8%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI-CV 118
P + + + S F GSV F C +GF L + K C++ W PS SI C+
Sbjct: 2087 PSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQ----WNPSPMSIQCI 2142
Query: 119 QEDC-RIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPI 176
C P I + Y G + +C++GF I+ S C G W++ +P
Sbjct: 2143 PVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIK----GEKKSTCEATGQWSSPIPT 2198
Query: 177 CQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW-SSS 233
C C P NG++ E T + + Y+C PG+K GS C N W S S
Sbjct: 2199 CHPVSCGEPPKVENGFL---EHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSES 2255
Query: 234 PPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGE 293
P C+ L+ C PP + +G E + G+ V+F+C+ GY L D + + G+
Sbjct: 2256 PLMCVPLD-CGKPPPIQNGFM-----KGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK 2309
Query: 294 WFPSYQVYCIKSEQTWPSTHETLL 317
W C+ ++ P E L
Sbjct: 2310 WNKKSNPKCMPAKCPEPPLLENQL 2333
Score = 92.0 bits (227), Expect = 1e-18
Identities = 82/278 (29%), Positives = 118/278 (42%), Gaps = 41/278 (14%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C+ P + NG G + + C +GF L+GA R+CL NG+ D
Sbjct: 2833 CSSPPVSANG--QVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLA--NGSWSGATPD--- 2885
Query: 117 CVQEDCRIP-QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-N 173
CV C P Q+ + Y +++ CHEG+ LH L C+ DG W+
Sbjct: 2886 CVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYI-----LHGAPKLTCQSDGNWDAE 2940
Query: 174 LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
+P+C+ C P ++G+ N SF G I Y+CFPG+KL G++ CL N WS
Sbjct: 2941 IPLCKPVNCGPPEDLAHGFPN----GFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWS 2996
Query: 232 SSPPRCLALEVCPLPPM----VSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYI 287
S P CL C P + V+ DF C G C G+ L I
Sbjct: 2997 GSSPSCLPCR-CSTPVIEYGTVNGTDFDC----------GKAARIQCFKGFKLLG-LSEI 3044
Query: 288 TCQY-GEW---FPSYQVYCIKSEQTWPSTHETLLTTWK 321
TC+ G+W FP + S P+ + ++WK
Sbjct: 3045 TCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWK 3082
Score = 92.0 bits (227), Expect = 1e-18
Identities = 74/244 (30%), Positives = 110/244 (45%), Gaps = 25/244 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P +GF P+G F G ++ C G+KL G + R CL NG+ W S S
Sbjct: 2949 CGPPEDLAHGF--PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLS--NGS--WSGSSPS- 3001
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LP 175
C+ C P IE ++ + G+ I C +GFK+ L C DG W++ P
Sbjct: 3002 CLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKL----LGLSEITCEADGQWSSGFP 3057
Query: 176 ICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSS 233
C+ C N +++ +TS VI+Y C G+ + GS+ L C + +WS
Sbjct: 3058 HCEHTSCGSLPMIPNAFIS----ETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQP 3113
Query: 234 PPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQY-G 292
P C L C PP V++ E + + + V+ C GY++ +D TCQ G
Sbjct: 3114 YPVCEPLS-CGSPPSVANA-----VATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDG 3167
Query: 293 EWFP 296
WFP
Sbjct: 3168 RWFP 3171
Score = 89.0 bits (219), Expect = 9e-18
Identities = 70/246 (28%), Positives = 114/246 (46%), Gaps = 25/246 (10%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C P + G PS + F GS ++ C GF L+G + LC +GT W S
Sbjct: 2380 LCTPPPLISFGVPIPSSALHF-GSTVKYSCVGGFFLRGNSTTLCQP--DGT--W-SSPLP 2433
Query: 116 ICVQEDCRIPQ-IEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW-NN 173
CV +C P+ I + I + + + TC GF++ + N +LC ++G W
Sbjct: 2434 ECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFEL----VGNTTTLCGENGHWLGG 2489
Query: 174 LPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
P C+ CL+P NG + ++L G ++Y C GF+L+G + L CL+ W
Sbjct: 2490 KPTCKAIECLKPKEILNGKFSYTDLH----YGQTVTYSCNRGFRLEGPSALTCLETGDWD 2545
Query: 232 SSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQY 291
P C A+ C P + +G FV Y++G ++ + C PG+ + + + TC+
Sbjct: 2546 VDAPSCNAIH-CDSPQPIENG-FV----EGADYSYGAIIIYSCFPGFQV-AGHAMQTCEE 2598
Query: 292 GEWFPS 297
W S
Sbjct: 2599 SGWSSS 2604
Score = 89.0 bits (219), Expect = 9e-18
Identities = 77/304 (25%), Positives = 119/304 (39%), Gaps = 73/304 (24%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P ENGF G + G++ + C GF++ G + C + GW S
Sbjct: 2556 CDSPQPIENGF--VEGADYSYGAIIIYSCFPGFQVAGHAMQTCEES-----GW-SSSIPT 2607
Query: 117 CVQEDCRIPQI-----------------------------------------------ED 129
C+ DC +P E
Sbjct: 2608 CMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKES 2667
Query: 130 AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NLPICQG--CLRPLAS 186
H+ + +G + TC+ G+++ L N V +C++DGTWN + P C C P A
Sbjct: 2668 PATHSSNFLYGTMVSYTCNPGYEL----LGNPVLICQEDGTWNGSAPSCISIECDLPTAP 2723
Query: 187 SNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLP 246
NG++ +E +G+ + Y C PG L GS CL+N WS + PRC A+ C P
Sbjct: 2724 ENGFLRFTETS----MGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAIS-CKKP 2778
Query: 247 PMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKSE 306
V +G Y + + + + CDPGY L + TCQ + + + CI +
Sbjct: 2779 NPVMNGSI-----KGSNYTYLSTLYYECDPGYVLNGTERR-TCQDDKNWDEDEPICIPVD 2832
Query: 307 QTWP 310
+ P
Sbjct: 2833 CSSP 2836
Score = 87.4 bits (215), Expect = 3e-17
Identities = 69/243 (28%), Positives = 111/243 (45%), Gaps = 23/243 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +P ENGF + G FE V R+ C G+K G+ +C + + W +
Sbjct: 2204 CGEPPKVENGFLEHTTGRIFESEV-RYQCNPGYKSVGSPVFVCQANRH----WHSESPLM 2258
Query: 117 CVQEDC-RIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL- 174
CV DC + P I++ + + + G K+ C+EG+++ + + C+ G WN
Sbjct: 2259 CVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYEL----VGDSSWTCQKSGKWNKKS 2314
Query: 175 -PICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
P C C P N V + EL T VG V+++ C G L G + L+CL + W+
Sbjct: 2315 NPKCMPAKCPEPPLLENQLV-LKELTTE--VG-VVTFSCKEGHVLQGPSVLKCLPSQQWN 2370
Query: 232 SSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQY 291
S P C + +C PP++S G P P + G+ V++ C G+ L + +
Sbjct: 2371 DSFPVC-KIVLCTPPPLISFG----VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPD 2425
Query: 292 GEW 294
G W
Sbjct: 2426 GTW 2428
Score = 85.5 bits (210), Expect = 1e-16
Identities = 82/319 (25%), Positives = 122/319 (38%), Gaps = 68/319 (21%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P NG G + S A + C+ GF+L G T LC G G
Sbjct: 2440 CPQPEEIPNGIIDVQGLAYL--STALYTCKPGFELVGNTTTLC-----GENGHWLGGKPT 2492
Query: 117 CVQEDCRIP-QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NL 174
C +C P +I + + +G+ + +C+ GF++ P C + G W+ +
Sbjct: 2493 CKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPS----ALTCLETGDWDVDA 2548
Query: 175 PICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSS 232
P C C P NG+V ++ + G +I Y CFPGF++ G A C + WSS
Sbjct: 2549 PSCNAIHCDSPQPIENGFVEGAD----YSYGAIIIYSCFPGFQVAGHAMQTC-EESGWSS 2603
Query: 233 SPPRCLALEVCPLPPMVSHGDFV--------------------CHPRP------------ 260
S P C+ ++ C LPP + GD P P
Sbjct: 2604 SIPTCMPID-CGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWE 2662
Query: 261 ---------CERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKSEQTWPS 311
+ +GT+V + C+PGY L + I + G W S CI E P+
Sbjct: 2663 NTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGS-APSCISIECDLPT 2721
Query: 312 THETLLTTWKIVAFTATSV 330
E + FT TS+
Sbjct: 2722 APEN-----GFLRFTETSM 2735
Score = 84.3 bits (207), Expect = 2e-16
Identities = 68/249 (27%), Positives = 106/249 (42%), Gaps = 29/249 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLK--HFNGTLGWIPSDN 114
C PG PENG SG ++ G+ F CQ+G++L G TK CL+ +N + +
Sbjct: 1789 CKAPGNPENGHS--SGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPY----- 1841
Query: 115 SICVQEDCRIPQI-EDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN 173
C C P I E+ I + G K+ C++G+ + + S C + +W++
Sbjct: 1842 --CKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLA----GDKESSCLANSSWSH 1895
Query: 174 LP-ICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW 230
P +C+ C P +NG +S L + SY C G+ L G + +EC + IW
Sbjct: 1896 SPPVCEPVKCSSPENINNGKYILSGLTYL----STASYSCDTGYSLQGPSIIECTASGIW 1951
Query: 231 SSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
+PP C L C PP + + + V + C GY+L
Sbjct: 1952 DRAPPAC-HLVFCGEPPAIKDAVITGN-----NFTFRNTVTYTCKEGYTLAGLDTIECLA 2005
Query: 291 YGEWFPSYQ 299
G+W S Q
Sbjct: 2006 DGKWSRSDQ 2014
Score = 83.6 bits (205), Expect = 4e-16
Identities = 66/264 (25%), Positives = 110/264 (41%), Gaps = 56/264 (21%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKH--FNGT-------- 106
C P ENGF S F+ GS + C +G+ L G ++ C + +NG
Sbjct: 1690 CGVPPPLENGFH--SADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVD 1747
Query: 107 ---LGWIPSDNSICVQED-----------------------CRIP-QIEDAEIHNKTYRH 139
+G S+++ C+ D C+ P E+ + Y
Sbjct: 1748 ECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTV 1807
Query: 140 GEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL-PICQG--CLRPLASSNGYVNISEL 196
G ++ +C EG+++ + C + G WN+L P C+ C +P NG +
Sbjct: 1808 GAEVTFSCQEGYQL----MGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIE---- 1859
Query: 197 QTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVC 256
+ +F G+ ++YRC G+ L G CL N WS SPP C ++ C P +++G ++
Sbjct: 1860 ELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVK-CSSPENINNGKYI- 1917
Query: 257 HPRPCERYNHGTVVEFYCDPGYSL 280
+ + + CD GYSL
Sbjct: 1918 ----LSGLTYLSTASYSCDTGYSL 1937
Score = 81.6 bits (200), Expect = 1e-15
Identities = 67/248 (27%), Positives = 99/248 (39%), Gaps = 33/248 (13%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P IPENG F GS + C G+ L G + CL + + W S +
Sbjct: 1847 CGKPAIPENGCIEELAFTF--GSKVTYRCNKGYTLAGDKESSCLANSS----WSHSP-PV 1899
Query: 117 CVQEDCRIPQIEDAEIHNKTY-----RHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW 171
C C P+ I+N Y + +C G+ ++ P + C G W
Sbjct: 1900 CEPVKCSSPE----NINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIE----CTASGIW 1951
Query: 172 NNLP-ICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL 228
+ P C C P A + + +F ++Y C G+ L G +ECL +
Sbjct: 1952 DRAPPACHLVFCGEPPAIKDAVIT----GNNFTFRNTVTYTCKEGYTLAGLDTIECLADG 2007
Query: 229 IWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYIT 288
WS S +CLA+ C PP+V H P R G + +YC GYSL + + +
Sbjct: 2008 KWSRSDQQCLAVS-CDEPPIVDHAS----PETAHRL-FGDIAFYYCSDGYSLADNSQLLC 2061
Query: 289 CQYGEWFP 296
G+W P
Sbjct: 2062 NAQGKWVP 2069
Score = 73.9 bits (180), Expect = 3e-13
Identities = 63/250 (25%), Positives = 103/250 (41%), Gaps = 26/250 (10%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
L C +P ++ T G F + + C++G+ L G CL W SD
Sbjct: 1960 LVFCGEPPAIKDAVIT--GNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK----WSRSD 2013
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYR-HGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW- 171
C+ C P I D +R G+ C +G+ + N LC G W
Sbjct: 2014 QQ-CLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLA----DNSQLLCNAQGKWV 2068
Query: 172 ----NNLPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
++P C C +P + S + S + F G+V+S++C GF L+ SA +EC+
Sbjct: 2069 PPEGQDMPRCIAHFCEKPPSVSYSILE-SVSKAKFAAGSVVSFKCMEGFVLNTSAKIECM 2127
Query: 226 QNLIWSSSPPRCLALEV-CPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDY 284
+ W+ SP + V C PP + +G Y+ G +V + C+ G+ + +
Sbjct: 2128 RGGQWNPSPMSIQCIPVRCGEPPSIMNG-----YASGSNYSFGAMVAYSCNKGFYIKGEK 2182
Query: 285 KYITCQYGEW 294
K G+W
Sbjct: 2183 KSTCEATGQW 2192
Score = 72.4 bits (176), Expect = 9e-13
Identities = 60/248 (24%), Positives = 111/248 (44%), Gaps = 36/248 (14%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P PE+GF S F S + C+ G++L+G +R+C ++ + G +I
Sbjct: 3241 CGKPESPEHGFVVGSKYTF--ESTIIYQCEPGYELEGNRERVCQENRQWSGGV-----AI 3293
Query: 117 CVQEDCRIPQIE----DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN 172
C + C P +E A+I N+T G ++ +C+ G+ + P + C ++GTW+
Sbjct: 3294 CKETRCETP-LEFLNGKADIENRTT--GPNVVYSCNRGYSLEGPSEAH----CTENGTWS 3346
Query: 173 N-LPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
+ +P+C+ C P + +SE + F V +S +C GF L G + C +
Sbjct: 3347 HPVPLCKPNPCPVPFVIPENAL-LSEKE--FYVDQNVSIKCREGFLLQGHGIITCNPDET 3403
Query: 230 WSSSPPRCLALEVCP---LPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKY 286
W+ + +C + P + ++ G Y +G ++ + C GY L +
Sbjct: 3404 WTQTSAKCEKISCGPPAHVENAIARG---------VHYQYGDMITYSCYSGYMLEGFLRS 3454
Query: 287 ITCQYGEW 294
+ + G W
Sbjct: 3455 VCLENGTW 3462
Score = 62.8 bits (151), Expect = 7e-10
Identities = 52/224 (23%), Positives = 94/224 (41%), Gaps = 23/224 (10%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQI-EDAEIH 133
F G++ + C G++L G +C + +GT W S S C+ +C +P E+ +
Sbjct: 2675 FLYGTMVSYTCNPGYELLGNPVLICQE--DGT--WNGSAPS-CISIECDLPTAPENGFLR 2729
Query: 134 NKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL-PICQG--CLRPLASSNGY 190
G + +C G + DL LC ++ W+ P C+ C +P NG
Sbjct: 2730 FTETSMGSAVQYSCKPGHILAGSDLR----LCLENRKWSGASPRCEAISCKKPNPVMNGS 2785
Query: 191 VNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVS 250
+ S ++ + + Y C PG+ L+G+ C + W P C+ ++ C PP+ +
Sbjct: 2786 IKGS----NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVD-CSSPPVSA 2840
Query: 251 HGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
+G + Y +E+ C+ G+ L + G W
Sbjct: 2841 NGQV-----RGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSW 2879
Score = 61.2 bits (147), Expect = 2e-09
Identities = 57/245 (23%), Positives = 97/245 (39%), Gaps = 28/245 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL-CLKHFNGTLGWIPSDNS 115
C P N T + S + C +G+ + T C K W P S
Sbjct: 3122 CGSPPSVANAVATGEAHTY--ESEVKLRCLEGYTMDTDTDTFTCQKDGR----WFPERIS 3175
Query: 116 ICVQEDCRIPQ-IEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-- 172
C + C +P+ I +H + ++ ++C EG+ + +S+C+ DGTW
Sbjct: 3176 -CSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVN----ISVCQLDGTWEPP 3230
Query: 173 -NLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
+ C C +P + +G+V + + + + I Y+C PG++L+G+ C +N
Sbjct: 3231 FSDESCSPVSCGKPESPEHGFV----VGSKYTFESTIIYQCEPGYELEGNRERVCQENRQ 3286
Query: 230 WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITC 289
WS C C P +F+ E G V + C+ GYSL +
Sbjct: 3287 WSGGVAICKETR-CETPL-----EFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCT 3340
Query: 290 QYGEW 294
+ G W
Sbjct: 3341 ENGTW 3345
Score = 60.8 bits (146), Expect = 3e-09
Identities = 57/234 (24%), Positives = 90/234 (38%), Gaps = 39/234 (16%)
Query: 85 CQDGFKLKGATKRLCLKHFNGTLGWIP--SDNSICVQEDCRIPQI-EDAEIHNKTYRHGE 141
C +G+ +G +C +GT W P SD S C C P+ E + Y
Sbjct: 3207 CAEGYTFEGVNISVC--QLDGT--WEPPFSDES-CSPVSCGKPESPEHGFVVGSKYTFES 3261
Query: 142 KLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQG--CLRPLASSNGYVNISELQT 198
+I C G+++ N +C+++ W+ + IC+ C PL NG +I T
Sbjct: 3262 TIIYQCEPGYELE----GNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTT 3317
Query: 199 SFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHP 258
G + Y C G+ L+G + C +N WS P C CP+P ++ +
Sbjct: 3318 ----GPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKP-NPCPVPFVIPENALLSEK 3372
Query: 259 RPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKSEQTWPST 312
EFY D S I C+ G + + ++TW T
Sbjct: 3373 ------------EFYVDQNVS-------IKCREGFLLQGHGIITCNPDETWTQT 3407
Score = 60.8 bits (146), Expect = 3e-09
Identities = 51/185 (27%), Positives = 81/185 (43%), Gaps = 25/185 (13%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGW-IPSDNSICVQEDCRIPQI--EDAEIHNKTYRH 139
+ C G+ L+G ++ C + NGT +P +C C +P + E+A + K +
Sbjct: 3323 YSCNRGYSLEGPSEAHCTE--NGTWSHPVP----LCKPNPCPVPFVIPENALLSEKEFYV 3376
Query: 140 GEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPI-CQ--GCLRPLASSNGYVNISEL 196
+ + I C EGF ++ H +++ C D TW C+ C P N
Sbjct: 3377 DQNVSIKCREGFLLQG---HGIIT-CNPDETWTQTSAKCEKISCGPPAHVENAIAR---- 3428
Query: 197 QTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVC 256
+ G +I+Y C+ G+ L+G CL+N W +SPP C A VC P +G
Sbjct: 3429 GVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTW-TSPPICRA--VCRFP--CQNGGICQ 3483
Query: 257 HPRPC 261
P C
Sbjct: 3484 RPNAC 3488
Score = 51.6 bits (122), Expect = 2e-06
Identities = 36/117 (30%), Positives = 47/117 (40%), Gaps = 7/117 (5%)
Query: 188 NGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPP 247
NGY + F RC PGF L GS+ + CL N +WS S C + CP
Sbjct: 386 NGYFIQNTCNNHF--NAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYC-RVRTCPHLR 442
Query: 248 MVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIK 304
HG C R + T CD GY L K +TCQ + + C++
Sbjct: 443 QPKHGHISCSTR---EMLYKTTCLVACDEGYRLEGSDK-LTCQGNSQWDGPEPRCVE 495
Score = 48.5 bits (114), Expect = 1e-05
Identities = 56/262 (21%), Positives = 95/262 (36%), Gaps = 64/262 (24%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN-KT 136
GS C GF+L G + CL T +P C + C +P + H+
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQP-LPH----CERISCGVPPPLENGFHSADD 1705
Query: 137 YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL-PIC------------------ 177
+ G + C+ G+ + L + C D+G+WN + P C
Sbjct: 1706 FYAGSTVTYQCNNGYYL----LGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASC 1761
Query: 178 -------------------QGCLRPLA------SSNGYVNISELQTSFPVGTVISYRCFP 212
+ C P+ NG+ + E+ T VG +++ C
Sbjct: 1762 LNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGH-SSGEIYT---VGAEVTFSCQE 1817
Query: 213 GFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEF 272
G++L G + CL++ W+ P C A+ C P + +G C + G+ V +
Sbjct: 1818 GYQLMGVTKITCLESGEWNHLIPYCKAVS-CGKPAIPENG---CIEELA--FTFGSKVTY 1871
Query: 273 YCDPGYSLTSDYKYITCQYGEW 294
C+ GY+L D + W
Sbjct: 1872 RCNKGYTLAGDKESSCLANSSW 1893
Score = 31.6 bits (70), Expect = 1.7
Identities = 19/59 (32%), Positives = 25/59 (42%), Gaps = 8/59 (13%)
Query: 243 CPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLT---SDYKYITCQYGEWFPSY 298
C +P +GDF+C P N G C GY T +D Y + G W P+Y
Sbjct: 727 CEIPFTPVNGDFICTPD-----NTGVNCTLTCLEGYDFTEGSTDKYYCAYEDGVWKPTY 780
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 88.6 bits (218), Expect = 1e-17
Identities = 75/253 (29%), Positives = 104/253 (41%), Gaps = 34/253 (13%)
Query: 52 DDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIP 111
D C DPG P +G R S F S R+ C G+ L G+ +R CL + + T G P
Sbjct: 3011 DATGTCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWT-GRQP 3067
Query: 112 SDNSICVQEDCRIPQIEDAEIHNKTYR-----HGEKLIITCHEGFKIRYPDLHNMVSLCR 166
C C P + K +R +I +C EG+ + P V C
Sbjct: 3068 E----CKAVQCGNP---GTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPS----VRQCT 3116
Query: 167 DDGTWN-NLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGF--KLDGSAY 221
+GTW+ LP C C P +NG + VG +SY C PG+ +L+GS
Sbjct: 3117 ANGTWSGTLPNCTIISCGDPGIPANGL----RYGDDYVVGQNVSYMCQPGYTMELNGSRI 3172
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLT 281
C N WS P C A+ CP PP +S+G ++ G + + C PGY L+
Sbjct: 3173 RTCTINGTWSGVMPTCRAV-TCPTPPQISNGRL-----EGTNFDWGFSISYICSPGYELS 3226
Query: 282 SDYKYITCQYGEW 294
G W
Sbjct: 3227 FPAVLTCVGNGTW 3239
Score = 79.7 bits (195), Expect = 5e-15
Identities = 74/257 (28%), Positives = 110/257 (42%), Gaps = 25/257 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTL-GWIPSDNS 115
C +PG NG G F SV + C +G+ L G + R C NGT G +P+
Sbjct: 3074 CGNPGTTANGKVFRIDGTTFSSSVI-YSCMEGYILSGPSVRQCTA--NGTWSGTLPN--- 3127
Query: 116 ICVQEDCRIPQIEDAEI-HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C P I + + Y G+ + C G+ + + + C +GTW+
Sbjct: 3128 -CTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNG--SRIRTCTINGTWSGV 3184
Query: 174 LPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
+P C+ C P SNG + T+F G ISY C PG++L A L C+ N WS
Sbjct: 3185 MPTCRAVTCPTPPQISNGRLE----GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3240
Query: 232 SSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQY 291
P+CL + C P + + G R + + + + V F C+ + L I
Sbjct: 3241 GEVPQCLP-KFCGDPGIPAQG-----KREGKSFIYQSEVSFSCNFPFILVGSSTRICQAD 3294
Query: 292 GEWFPSYQVYCIKSEQT 308
G W S +CI+ QT
Sbjct: 3295 GTWSGS-SPHCIEPTQT 3310
Score = 74.3 bits (181), Expect = 2e-13
Identities = 70/252 (27%), Positives = 101/252 (40%), Gaps = 34/252 (13%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + + G+ + C DG++L + +GT W + +
Sbjct: 2592 CGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT--WSNHNKTP 2647
Query: 117 -CVQEDCRIPQIED--------AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRD 167
CV C P I ++ Y + K++ +C G Y L C
Sbjct: 2648 RCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPG----YHGLGPASIECLP 2701
Query: 168 DGTW---NNLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYL 222
+GTW N P CQ C NG N QTS+ G+ + C GF L GSA
Sbjct: 2702 NGTWSWRNERPYCQIISCGELPTPPNG--NKIGTQTSY--GSTAIFTCDLGFMLVGSAVR 2757
Query: 223 ECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTS 282
ECL + +WS S RCLA C +P ++ +G + E Y + V + C+PG+ L
Sbjct: 2758 ECLSSGLWSESETRCLAGH-CGIPELIVNGQVI-----GENYGYRDTVVYQCNPGFRLIG 2811
Query: 283 DYKYITCQYGEW 294
I Q W
Sbjct: 2812 SSVRICQQDHNW 2823
Score = 70.9 bits (172), Expect = 3e-12
Identities = 66/252 (26%), Positives = 108/252 (42%), Gaps = 23/252 (9%)
Query: 57 CADPGIPENGFR-TPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
C+ P P +G+ + +GG SV R+ C GF+L G + +C K G W +
Sbjct: 2529 CSTPESPPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW-DAPVP 2585
Query: 116 ICVQEDCRIPQI-EDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C IP+ + I Y G ++ C++G+++ +L ++C+ DGTW+N
Sbjct: 2586 ACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKEL--TTAVCQSDGTWSNH 2643
Query: 174 --LPICQGCLRPLASS----NGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
P C P +S +G I + + T + + C PG+ G A +ECL N
Sbjct: 2644 NKTPRCVVVTCPSINSFILEHGRWRIVN-GSHYEYKTKVVFSCDPGYHGLGPASIECLPN 2702
Query: 228 LIWS--SSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYK 285
WS + P C + C P +G+ + + ++G+ F CD G+ L
Sbjct: 2703 GTWSWRNERPYCQIIS-CGELPTPPNGNKI-----GTQTSYGSTAIFTCDLGFMLVGSAV 2756
Query: 286 YITCQYGEWFPS 297
G W S
Sbjct: 2757 RECLSSGLWSES 2768
Score = 70.5 bits (171), Expect = 3e-12
Identities = 69/297 (23%), Positives = 104/297 (35%), Gaps = 78/297 (26%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGF--KLKGATKRLCLKHFNGTL-GWIPSD 113
C DPGIP NG R G + G + CQ G+ +L G+ R C NGT G +P+
Sbjct: 3133 CGDPGIPANGLRY--GDDYVVGQNVSYMCQPGYTMELNGSRIRTCT--INGTWSGVMPTC 3188
Query: 114 NSICVQEDCRIPQIEDAEIHNKTY------------------------------------ 137
++ PQI + + +
Sbjct: 3189 RAVTCPTP---PQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQ 3245
Query: 138 ----------------RHGEKLIITCHEGFKIRYPDL--HNMVSLCRDDGTWNNL----- 174
R G+ I F +P + + +C+ DGTW+
Sbjct: 3246 CLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCI 3305
Query: 175 -PICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSS 233
P C P +G N + F VG+V+ + C G L GS CL +L WS
Sbjct: 3306 EPTQTSCENPGVPRHGSQNNT---FGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGI 3362
Query: 234 PPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
P C+ C P +H + V P +HG + + C PG+ L ++ C+
Sbjct: 3363 QPECIP-HSCKQPETPAHANVVGMDLP----SHGYTLIYTCQPGFFLAGGTEHRVCR 3414
Score = 67.4 bits (163), Expect = 3e-11
Identities = 59/227 (25%), Positives = 100/227 (44%), Gaps = 26/227 (11%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHG-- 140
+ C GF+L G++ R+C + N + G +PS CV C P + I+ +T +G
Sbjct: 2801 YQCNPGFRLIGSSVRICQQDHNWS-GQLPS----CVPVSCGHP---GSPIYGRTSGNGFN 2852
Query: 141 --EKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ--GCLRPLASSNGYVNISE 195
+ + +C+ G+ ++ P + C+ + W++ P +C+ C P +N
Sbjct: 2853 FNDVVTFSCNIGYLMQGPTK----AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKI 2908
Query: 196 LQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFV 255
+F GTV+ Y C PG+ L GS+ L C N W P C+ ++ C P + +
Sbjct: 2909 EHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMID-CGHPGVPPNAVL- 2966
Query: 256 CHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYC 302
E+Y G+ V + C SL TCQ + Q +C
Sbjct: 2967 ----SGEKYTFGSTVHYSCTGKRSLLGQSSR-TCQLNGHWSGSQPHC 3008
Score = 62.8 bits (151), Expect = 7e-10
Identities = 54/205 (26%), Positives = 86/205 (41%), Gaps = 23/205 (11%)
Query: 57 CADPGIPENGFRTPS--GGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN 114
C+DPGIP N R G F G+V + C G+ L G++ +C + G
Sbjct: 2893 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN-----GQWDKPL 2947
Query: 115 SICVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN- 172
C+ DC P + +A + + Y G + +C + L C+ +G W+
Sbjct: 2948 PECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL----LGQSSRTCQLNGHWSG 3003
Query: 173 NLPICQG-----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
+ P C G C P +G S +++F + + Y C G+ L GS CL N
Sbjct: 3004 SQPHCSGDATGTCGDPGTPGHG----SRQESNFRTKSTVRYACDTGYILHGSEERTCLAN 3059
Query: 228 LIWSSSPPRCLALEVCPLPPMVSHG 252
W+ P C A++ C P ++G
Sbjct: 3060 GSWTGRQPECKAVQ-CGNPGTTANG 3083
Score = 54.3 bits (129), Expect = 2e-07
Identities = 53/207 (25%), Positives = 78/207 (37%), Gaps = 21/207 (10%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDC-RIPQIEDAEIHNKTYRHGE 141
F C G+ G CL NGT W ++ C C +P + +G
Sbjct: 2683 FSCDPGYHGLGPASIECLP--NGTWSW-RNERPYCQIISCGELPTPPNGNKIGTQTSYGS 2739
Query: 142 KLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP---ICQGCLRPLASSNGYVNISELQT 198
I TC GF + + + V C G W+ + C P NG V +
Sbjct: 2740 TAIFTCDLGFML----VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQV----IGE 2791
Query: 199 SFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHP 258
++ + Y+C PGF+L GS+ C Q+ WS P C+ + C P G +
Sbjct: 2792 NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS-CGHP-----GSPIYGR 2845
Query: 259 RPCERYNHGTVVEFYCDPGYSLTSDYK 285
+N VV F C+ GY + K
Sbjct: 2846 TSGNGFNFNDVVTFSCNIGYLMQGPTK 2872
Score = 47.4 bits (111), Expect = 3e-05
Identities = 26/65 (40%), Positives = 34/65 (52%), Gaps = 6/65 (9%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPP 235
Q C P NG+V + F VG IS+ CFPG+ L G++ L CL + W+ P
Sbjct: 2182 QSCPDPRPFRNGFV----IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLP 2237
Query: 236 RCLAL 240
RC AL
Sbjct: 2238 RCEAL 2242
Score = 41.2 bits (95), Expect = 0.002
Identities = 64/248 (25%), Positives = 87/248 (35%), Gaps = 50/248 (20%)
Query: 62 IPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW-------IPSDN 114
+PE F G F GS F C G+ L G+ C N W I
Sbjct: 1841 VPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1900
Query: 115 SICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIR---YPDLHNMVSLCRDDGTW 171
I + I E ++ K+ + G +++ + HN SL DG
Sbjct: 1901 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGD 1960
Query: 172 NNLPIC---QGCLRP----LASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
NN P G P S+N Y+N Q+ V GF L+ +A
Sbjct: 1961 NNAPRLGSYSGTTIPHLLNSTSNNLYLNF---QSDISVSAA-------GFHLEYTA---- 2006
Query: 225 LQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDY 284
+ L+ CP P S G + +RY G VV F CD GYSL +
Sbjct: 2007 -------------IGLDSCPEPQTPSSGIKIG-----DRYMVGDVVSFQCDQGYSL-QGH 2047
Query: 285 KYITCQYG 292
+ITC G
Sbjct: 2048 SHITCMPG 2055
Score = 40.0 bits (92), Expect = 0.005
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 2/48 (4%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L+ C DPGIP+ G R G F G F C G++L+G ++ +CL
Sbjct: 1138 NLEPCEDPGIPQYGSRI--GFNFGIGDTLTFSCSSGYRLEGTSEIICL 1183
Score = 39.3 bits (90), Expect = 0.008
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLALEVCP 244
F +G +I Y+C PGF L G+A L C + L +PP C L CP
Sbjct: 2373 FEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL--CP 2417
Score = 38.9 bits (89), Expect = 0.011
Identities = 22/67 (32%), Positives = 30/67 (44%), Gaps = 3/67 (4%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C DPG PENG R G F GS +F C + + L+GA C + W
Sbjct: 445 LCPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAW-SDHRP 501
Query: 116 ICVQEDC 122
+C + C
Sbjct: 502 VCKVKTC 508
Score = 37.7 bits (86), Expect = 0.024
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 4/62 (6%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPG+P NG R G G F C G++L+G + C++ N W PS +
Sbjct: 1488 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYF-WQPSP-PV 1543
Query: 117 CV 118
C+
Sbjct: 1544 CI 1545
Score = 37.4 bits (85), Expect = 0.031
Identities = 19/50 (38%), Positives = 23/50 (46%), Gaps = 4/50 (8%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WSSSPPRCLALEVC 243
T F VG I Y C G+ LDG L C+ N + W P C A + C
Sbjct: 152 TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDAC 201
Score = 37.4 bits (85), Expect = 0.031
Identities = 15/48 (31%), Positives = 30/48 (62%), Gaps = 2/48 (4%)
Query: 194 SELQTSFPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA 239
S + +F +G +++ C G++L+G++ + CL +WS+ PRC+A
Sbjct: 1152 SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1199
Score = 37.0 bits (84), Expect = 0.041
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L C DPGIP+ G++ G F GS + C G+ L G++ C+
Sbjct: 1310 ELSHCEDPGIPQFGYKISDQG-HFAGSTIIYGCNPGYTLHGSSLLKCM 1356
Score = 36.6 bits (83), Expect = 0.053
Identities = 52/238 (21%), Positives = 84/238 (35%), Gaps = 58/238 (24%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPG NG R G + GS ++C G+ L+G + C+ +G GW +PS
Sbjct: 1661 CFDPGNIMNGTRL--GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLI--------ITCHEGFKIRYPDLHNMV--- 162
++ C + + K Y G + F LH++V
Sbjct: 1719 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVY 1778
Query: 163 ----------SLCRDDGTWNNLPICQG---CLR-------------------PLASSNGY 190
S + +LP+ G +R P SS
Sbjct: 1779 DGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQC 1838
Query: 191 VNISE------LQTSFPVGTVISYRCFPGFKLDGSAYLEC--LQNLI--WSSSPPRCL 238
++ E + F VG+ + + C PG+ L GS + C + N + W+ S P C+
Sbjct: 1839 SSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1896
Score = 36.2 bits (82), Expect = 0.070
Identities = 19/43 (44%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLC 99
C DPG P G R G F V RF CQ GF+L G +C
Sbjct: 624 CGDPGTPLYGIREGDG--FSNRDVLRFECQFGFELIGEKSIVC 664
Score = 36.2 bits (82), Expect = 0.070
Identities = 14/40 (35%), Positives = 22/40 (55%), Gaps = 3/40 (7%)
Query: 203 GTVISYRCFPGFKLDGSAYLECLQ---NLIWSSSPPRCLA 239
G + ++C PG++L G + C+Q W SPP C+A
Sbjct: 1507 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1546
Score = 35.4 bits (80), Expect = 0.12
Identities = 18/62 (29%), Positives = 32/62 (51%), Gaps = 6/62 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPPRC 237
C P S+G ++ + VG V+S++C G+ L G +++ C+ + W+ P C
Sbjct: 2012 CPEPQTPSSGI----KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067
Query: 238 LA 239
LA
Sbjct: 2068 LA 2069
Score = 35.0 bits (79), Expect = 0.15
Identities = 19/46 (41%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKH 102
C DPGIP +G R G F GS F C G++L LC K+
Sbjct: 970 CLDPGIPVHGRRY--GHDFSIGSTVSFSCDSGYRLSHEEPLLCEKN 1013
Score = 35.0 bits (79), Expect = 0.15
Identities = 67/287 (23%), Positives = 97/287 (33%), Gaps = 69/287 (24%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
LQ C DP NGF G F G F C G+ L G + CL
Sbjct: 2181 LQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGNSALTCL------------- 2225
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN 173
+ + + +P+ E N T +G G+ YP+ + L R
Sbjct: 2226 HGVSRNWNHPLPRCEALCGGNITAMNGT----IYSPGYPDEYPNFQDCFWLVR------- 2274
Query: 174 LPICQGCLRPLASSNG-YVNISELQTSFPVGTVISY-----------RCFPGFKLDGSAY 221
+ NG Y+N + LQT P+ I+ F G S Y
Sbjct: 2275 ----------VPPGNGIYINFTVLQTE-PIYDFITVWDGPDQNSPQIGQFSGNTALESVY 2323
Query: 222 LECLQNLIWSSSP----------PRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVE 271
Q LI S L VC PP V + + + + + G ++
Sbjct: 2324 STSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTED---DEFEIGDIIR 2380
Query: 272 FYCDPGYSLTSDYKYITCQYGEWF------PSYQVYCIKSEQTWPST 312
+ C PG++L + +TC+ GE P QV C +E ST
Sbjct: 2381 YQCLPGFTLVGN-AILTCRLGERLQMDGAPPVCQVLCPANELRLDST 2426
Score = 33.9 bits (76), Expect = 0.34
Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 2/39 (5%)
Query: 203 GTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA 239
G+ I Y C PG+ L GS+ L+C+ + W P C+A
Sbjct: 1334 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1372
Score = 33.5 bits (75), Expect = 0.45
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
F +G+ +S+ C G++L L C +N WS P C AL
Sbjct: 986 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 1026
Score = 32.0 bits (71), Expect = 1.3
Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 21/89 (23%)
Query: 150 GFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYR 209
GFK+ Y ++ C D GT L + +G+ N V+ +
Sbjct: 611 GFKVNYKEIEK--ESCGDPGT---------PLYGIREGDGFSNRD----------VLRFE 649
Query: 210 CFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
C GF+L G + C +N WS++ P C+
Sbjct: 650 CQFGFELIGEKSIVCQENNQWSANIPICI 678
Score = 31.6 bits (70), Expect = 1.7
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
L C +P P +G + G + G V F C G+ L+G + C+
Sbjct: 2009 LDSCPEPQTPSSGIKI--GDRYMVGDVVSFQCDQGYSLQGHSHITCM 2053
Score = 29.6 bits (65), Expect = 6.5
Identities = 13/30 (43%), Positives = 17/30 (56%), Gaps = 1/30 (3%)
Query: 264 YNHGTVVEFYCDPGYSLTSDYKYITCQYGE 293
Y G+ V +YCD GY L Y +TC G+
Sbjct: 1677 YKLGSTVTYYCDAGYVL-QGYSTLTCIMGD 1705
Score = 29.3 bits (64), Expect = 8.5
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 5/64 (7%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPGIP N R G F GS C++GF T+ + +G + W IP
Sbjct: 794 CPDPGIPINARR--FGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851
Query: 114 NSIC 117
+ C
Sbjct: 852 GAPC 855
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 88.6 bits (218), Expect = 1e-17
Identities = 75/253 (29%), Positives = 104/253 (41%), Gaps = 34/253 (13%)
Query: 52 DDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIP 111
D C DPG P +G R S F S R+ C G+ L G+ +R CL + + T G P
Sbjct: 3051 DATGTCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWT-GRQP 3107
Query: 112 SDNSICVQEDCRIPQIEDAEIHNKTYR-----HGEKLIITCHEGFKIRYPDLHNMVSLCR 166
C C P + K +R +I +C EG+ + P V C
Sbjct: 3108 E----CKAVQCGNP---GTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPS----VRQCT 3156
Query: 167 DDGTWN-NLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGF--KLDGSAY 221
+GTW+ LP C C P +NG + VG +SY C PG+ +L+GS
Sbjct: 3157 ANGTWSGTLPNCTIISCGDPGIPANGL----RYGDDYVVGQNVSYMCQPGYTMELNGSRI 3212
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLT 281
C N WS P C A+ CP PP +S+G ++ G + + C PGY L+
Sbjct: 3213 RTCTINGTWSGVMPTCRAV-TCPTPPQISNGRL-----EGTNFDWGFSISYICSPGYELS 3266
Query: 282 SDYKYITCQYGEW 294
G W
Sbjct: 3267 FPAVLTCVGNGTW 3279
Score = 79.7 bits (195), Expect = 5e-15
Identities = 74/257 (28%), Positives = 110/257 (42%), Gaps = 25/257 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTL-GWIPSDNS 115
C +PG NG G F SV + C +G+ L G + R C NGT G +P+
Sbjct: 3114 CGNPGTTANGKVFRIDGTTFSSSVI-YSCMEGYILSGPSVRQCTA--NGTWSGTLPN--- 3167
Query: 116 ICVQEDCRIPQIEDAEI-HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C P I + + Y G+ + C G+ + + + C +GTW+
Sbjct: 3168 -CTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNG--SRIRTCTINGTWSGV 3224
Query: 174 LPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
+P C+ C P SNG + T+F G ISY C PG++L A L C+ N WS
Sbjct: 3225 MPTCRAVTCPTPPQISNGRLE----GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3280
Query: 232 SSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQY 291
P+CL + C P + + G R + + + + V F C+ + L I
Sbjct: 3281 GEVPQCLP-KFCGDPGIPAQG-----KREGKSFIYQSEVSFSCNFPFILVGSSTRICQAD 3334
Query: 292 GEWFPSYQVYCIKSEQT 308
G W S +CI+ QT
Sbjct: 3335 GTWSGS-SPHCIEPTQT 3350
Score = 74.3 bits (181), Expect = 2e-13
Identities = 70/252 (27%), Positives = 101/252 (40%), Gaps = 34/252 (13%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + + G+ + C DG++L + +GT W + +
Sbjct: 2632 CGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT--WSNHNKTP 2687
Query: 117 -CVQEDCRIPQIED--------AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRD 167
CV C P I ++ Y + K++ +C G Y L C
Sbjct: 2688 RCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPG----YHGLGPASIECLP 2741
Query: 168 DGTW---NNLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYL 222
+GTW N P CQ C NG N QTS+ G+ + C GF L GSA
Sbjct: 2742 NGTWSWRNERPYCQIISCGELPTPPNG--NKIGTQTSY--GSTAIFTCDLGFMLVGSAVR 2797
Query: 223 ECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTS 282
ECL + +WS S RCLA C +P ++ +G + E Y + V + C+PG+ L
Sbjct: 2798 ECLSSGLWSESETRCLAGH-CGIPELIVNGQVI-----GENYGYRDTVVYQCNPGFRLIG 2851
Query: 283 DYKYITCQYGEW 294
I Q W
Sbjct: 2852 SSVRICQQDHNW 2863
Score = 70.9 bits (172), Expect = 3e-12
Identities = 66/252 (26%), Positives = 108/252 (42%), Gaps = 23/252 (9%)
Query: 57 CADPGIPENGFR-TPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
C+ P P +G+ + +GG SV R+ C GF+L G + +C K G W +
Sbjct: 2569 CSTPESPPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW-DAPVP 2625
Query: 116 ICVQEDCRIPQI-EDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C IP+ + I Y G ++ C++G+++ +L ++C+ DGTW+N
Sbjct: 2626 ACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKEL--TTAVCQSDGTWSNH 2683
Query: 174 --LPICQGCLRPLASS----NGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
P C P +S +G I + + T + + C PG+ G A +ECL N
Sbjct: 2684 NKTPRCVVVTCPSINSFILEHGRWRIVN-GSHYEYKTKVVFSCDPGYHGLGPASIECLPN 2742
Query: 228 LIWS--SSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYK 285
WS + P C + C P +G+ + + ++G+ F CD G+ L
Sbjct: 2743 GTWSWRNERPYCQIIS-CGELPTPPNGNKI-----GTQTSYGSTAIFTCDLGFMLVGSAV 2796
Query: 286 YITCQYGEWFPS 297
G W S
Sbjct: 2797 RECLSSGLWSES 2808
Score = 70.5 bits (171), Expect = 3e-12
Identities = 69/297 (23%), Positives = 104/297 (35%), Gaps = 78/297 (26%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGF--KLKGATKRLCLKHFNGTL-GWIPSD 113
C DPGIP NG R G + G + CQ G+ +L G+ R C NGT G +P+
Sbjct: 3173 CGDPGIPANGLRY--GDDYVVGQNVSYMCQPGYTMELNGSRIRTCT--INGTWSGVMPTC 3228
Query: 114 NSICVQEDCRIPQIEDAEIHNKTY------------------------------------ 137
++ PQI + + +
Sbjct: 3229 RAVTCPTP---PQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQ 3285
Query: 138 ----------------RHGEKLIITCHEGFKIRYPDL--HNMVSLCRDDGTWNNL----- 174
R G+ I F +P + + +C+ DGTW+
Sbjct: 3286 CLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCI 3345
Query: 175 -PICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSS 233
P C P +G N + F VG+V+ + C G L GS CL +L WS
Sbjct: 3346 EPTQTSCENPGVPRHGSQNNT---FGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGI 3402
Query: 234 PPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
P C+ C P +H + V P +HG + + C PG+ L ++ C+
Sbjct: 3403 QPECIP-HSCKQPETPAHANVVGMDLP----SHGYTLIYTCQPGFFLAGGTEHRVCR 3454
Score = 67.4 bits (163), Expect = 3e-11
Identities = 59/227 (25%), Positives = 100/227 (44%), Gaps = 26/227 (11%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHG-- 140
+ C GF+L G++ R+C + N + G +PS CV C P + I+ +T +G
Sbjct: 2841 YQCNPGFRLIGSSVRICQQDHNWS-GQLPS----CVPVSCGHP---GSPIYGRTSGNGFN 2892
Query: 141 --EKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ--GCLRPLASSNGYVNISE 195
+ + +C+ G+ ++ P + C+ + W++ P +C+ C P +N
Sbjct: 2893 FNDVVTFSCNIGYLMQGPTK----AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKI 2948
Query: 196 LQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFV 255
+F GTV+ Y C PG+ L GS+ L C N W P C+ ++ C P + +
Sbjct: 2949 EHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMID-CGHPGVPPNAVL- 3006
Query: 256 CHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYC 302
E+Y G+ V + C SL TCQ + Q +C
Sbjct: 3007 ----SGEKYTFGSTVHYSCTGKRSLLGQSSR-TCQLNGHWSGSQPHC 3048
Score = 62.8 bits (151), Expect = 7e-10
Identities = 54/205 (26%), Positives = 86/205 (41%), Gaps = 23/205 (11%)
Query: 57 CADPGIPENGFRTPS--GGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN 114
C+DPGIP N R G F G+V + C G+ L G++ +C + G
Sbjct: 2933 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN-----GQWDKPL 2987
Query: 115 SICVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN- 172
C+ DC P + +A + + Y G + +C + L C+ +G W+
Sbjct: 2988 PECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL----LGQSSRTCQLNGHWSG 3043
Query: 173 NLPICQG-----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
+ P C G C P +G S +++F + + Y C G+ L GS CL N
Sbjct: 3044 SQPHCSGDATGTCGDPGTPGHG----SRQESNFRTKSTVRYACDTGYILHGSEERTCLAN 3099
Query: 228 LIWSSSPPRCLALEVCPLPPMVSHG 252
W+ P C A++ C P ++G
Sbjct: 3100 GSWTGRQPECKAVQ-CGNPGTTANG 3123
Score = 54.3 bits (129), Expect = 2e-07
Identities = 53/207 (25%), Positives = 78/207 (37%), Gaps = 21/207 (10%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDC-RIPQIEDAEIHNKTYRHGE 141
F C G+ G CL NGT W ++ C C +P + +G
Sbjct: 2723 FSCDPGYHGLGPASIECLP--NGTWSW-RNERPYCQIISCGELPTPPNGNKIGTQTSYGS 2779
Query: 142 KLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP---ICQGCLRPLASSNGYVNISELQT 198
I TC GF + + + V C G W+ + C P NG V +
Sbjct: 2780 TAIFTCDLGFML----VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQV----IGE 2831
Query: 199 SFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHP 258
++ + Y+C PGF+L GS+ C Q+ WS P C+ + C P G +
Sbjct: 2832 NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS-CGHP-----GSPIYGR 2885
Query: 259 RPCERYNHGTVVEFYCDPGYSLTSDYK 285
+N VV F C+ GY + K
Sbjct: 2886 TSGNGFNFNDVVTFSCNIGYLMQGPTK 2912
Score = 47.4 bits (111), Expect = 3e-05
Identities = 26/65 (40%), Positives = 34/65 (52%), Gaps = 6/65 (9%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPP 235
Q C P NG+V + F VG IS+ CFPG+ L G++ L CL + W+ P
Sbjct: 2222 QSCPDPRPFRNGFV----IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLP 2277
Query: 236 RCLAL 240
RC AL
Sbjct: 2278 RCEAL 2282
Score = 41.2 bits (95), Expect = 0.002
Identities = 64/248 (25%), Positives = 87/248 (35%), Gaps = 50/248 (20%)
Query: 62 IPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW-------IPSDN 114
+PE F G F GS F C G+ L G+ C N W I
Sbjct: 1881 VPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1940
Query: 115 SICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIR---YPDLHNMVSLCRDDGTW 171
I + I E ++ K+ + G +++ + HN SL DG
Sbjct: 1941 GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGD 2000
Query: 172 NNLPIC---QGCLRP----LASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
NN P G P S+N Y+N Q+ V GF L+ +A
Sbjct: 2001 NNAPRLGSYSGTTIPHLLNSTSNNLYLNF---QSDISVSAA-------GFHLEYTA---- 2046
Query: 225 LQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDY 284
+ L+ CP P S G + +RY G VV F CD GYSL +
Sbjct: 2047 -------------IGLDSCPEPQTPSSGIKIG-----DRYMVGDVVSFQCDQGYSL-QGH 2087
Query: 285 KYITCQYG 292
+ITC G
Sbjct: 2088 SHITCMPG 2095
Score = 40.0 bits (92), Expect = 0.005
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 2/48 (4%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L+ C DPGIP+ G R G F G F C G++L+G ++ +CL
Sbjct: 1178 NLEPCEDPGIPQYGSRI--GFNFGIGDTLTFSCSSGYRLEGTSEIICL 1223
Score = 39.3 bits (90), Expect = 0.008
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLALEVCP 244
F +G +I Y+C PGF L G+A L C + L +PP C L CP
Sbjct: 2413 FEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL--CP 2457
Score = 38.9 bits (89), Expect = 0.011
Identities = 22/67 (32%), Positives = 30/67 (44%), Gaps = 3/67 (4%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C DPG PENG R G F GS +F C + + L+GA C + W
Sbjct: 485 LCPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAW-SDHRP 541
Query: 116 ICVQEDC 122
+C + C
Sbjct: 542 VCKVKTC 548
Score = 37.7 bits (86), Expect = 0.024
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 4/62 (6%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPG+P NG R G G F C G++L+G + C++ N W PS +
Sbjct: 1528 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYF-WQPSP-PV 1583
Query: 117 CV 118
C+
Sbjct: 1584 CI 1585
Score = 37.4 bits (85), Expect = 0.031
Identities = 19/50 (38%), Positives = 23/50 (46%), Gaps = 4/50 (8%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WSSSPPRCLALEVC 243
T F VG I Y C G+ LDG L C+ N + W P C A + C
Sbjct: 192 TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDAC 241
Score = 37.4 bits (85), Expect = 0.031
Identities = 15/48 (31%), Positives = 30/48 (62%), Gaps = 2/48 (4%)
Query: 194 SELQTSFPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA 239
S + +F +G +++ C G++L+G++ + CL +WS+ PRC+A
Sbjct: 1192 SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA 1239
Score = 37.0 bits (84), Expect = 0.041
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L C DPGIP+ G++ G F GS + C G+ L G++ C+
Sbjct: 1350 ELSHCEDPGIPQFGYKISDQG-HFAGSTIIYGCNPGYTLHGSSLLKCM 1396
Score = 36.6 bits (83), Expect = 0.053
Identities = 52/238 (21%), Positives = 84/238 (35%), Gaps = 58/238 (24%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPG NG R G + GS ++C G+ L+G + C+ +G GW +PS
Sbjct: 1701 CFDPGNIMNGTRL--GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1758
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLI--------ITCHEGFKIRYPDLHNMV--- 162
++ C + + K Y G + F LH++V
Sbjct: 1759 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVY 1818
Query: 163 ----------SLCRDDGTWNNLPICQG---CLR-------------------PLASSNGY 190
S + +LP+ G +R P SS
Sbjct: 1819 DGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQC 1878
Query: 191 VNISE------LQTSFPVGTVISYRCFPGFKLDGSAYLEC--LQNLI--WSSSPPRCL 238
++ E + F VG+ + + C PG+ L GS + C + N + W+ S P C+
Sbjct: 1879 SSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCI 1936
Score = 36.2 bits (82), Expect = 0.070
Identities = 19/43 (44%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLC 99
C DPG P G R G F V RF CQ GF+L G +C
Sbjct: 664 CGDPGTPLYGIREGDG--FSNRDVLRFECQFGFELIGEKSIVC 704
Score = 36.2 bits (82), Expect = 0.070
Identities = 14/40 (35%), Positives = 22/40 (55%), Gaps = 3/40 (7%)
Query: 203 GTVISYRCFPGFKLDGSAYLECLQ---NLIWSSSPPRCLA 239
G + ++C PG++L G + C+Q W SPP C+A
Sbjct: 1547 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1586
Score = 35.4 bits (80), Expect = 0.12
Identities = 18/62 (29%), Positives = 32/62 (51%), Gaps = 6/62 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPPRC 237
C P S+G ++ + VG V+S++C G+ L G +++ C+ + W+ P C
Sbjct: 2052 CPEPQTPSSGI----KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2107
Query: 238 LA 239
LA
Sbjct: 2108 LA 2109
Score = 35.0 bits (79), Expect = 0.15
Identities = 19/46 (41%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKH 102
C DPGIP +G R G F GS F C G++L LC K+
Sbjct: 1010 CLDPGIPVHGRRY--GHDFSIGSTVSFSCDSGYRLSHEEPLLCEKN 1053
Score = 35.0 bits (79), Expect = 0.15
Identities = 67/287 (23%), Positives = 97/287 (33%), Gaps = 69/287 (24%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
LQ C DP NGF G F G F C G+ L G + CL
Sbjct: 2221 LQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGNSALTCL------------- 2265
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN 173
+ + + +P+ E N T +G G+ YP+ + L R
Sbjct: 2266 HGVSRNWNHPLPRCEALCGGNITAMNGT----IYSPGYPDEYPNFQDCFWLVR------- 2314
Query: 174 LPICQGCLRPLASSNG-YVNISELQTSFPVGTVISY-----------RCFPGFKLDGSAY 221
+ NG Y+N + LQT P+ I+ F G S Y
Sbjct: 2315 ----------VPPGNGIYINFTVLQTE-PIYDFITVWDGPDQNSPQIGQFSGNTALESVY 2363
Query: 222 LECLQNLIWSSSP----------PRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVE 271
Q LI S L VC PP V + + + + + G ++
Sbjct: 2364 STSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTED---DEFEIGDIIR 2420
Query: 272 FYCDPGYSLTSDYKYITCQYGEWF------PSYQVYCIKSEQTWPST 312
+ C PG++L + +TC+ GE P QV C +E ST
Sbjct: 2421 YQCLPGFTLVGN-AILTCRLGERLQMDGAPPVCQVLCPANELRLDST 2466
Score = 33.9 bits (76), Expect = 0.34
Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 2/39 (5%)
Query: 203 GTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA 239
G+ I Y C PG+ L GS+ L+C+ + W P C+A
Sbjct: 1374 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1412
Score = 33.5 bits (75), Expect = 0.45
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
F +G+ +S+ C G++L L C +N WS P C AL
Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 1066
Score = 32.0 bits (71), Expect = 1.3
Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 21/89 (23%)
Query: 150 GFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYR 209
GFK+ Y ++ C D GT L + +G+ N V+ +
Sbjct: 651 GFKVNYKEIEK--ESCGDPGT---------PLYGIREGDGFSNRD----------VLRFE 689
Query: 210 CFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
C GF+L G + C +N WS++ P C+
Sbjct: 690 CQFGFELIGEKSIVCQENNQWSANIPICI 718
Score = 31.6 bits (70), Expect = 1.7
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
L C +P P +G + G + G V F C G+ L+G + C+
Sbjct: 2049 LDSCPEPQTPSSGIKI--GDRYMVGDVVSFQCDQGYSLQGHSHITCM 2093
Score = 29.6 bits (65), Expect = 6.5
Identities = 13/30 (43%), Positives = 17/30 (56%), Gaps = 1/30 (3%)
Query: 264 YNHGTVVEFYCDPGYSLTSDYKYITCQYGE 293
Y G+ V +YCD GY L Y +TC G+
Sbjct: 1717 YKLGSTVTYYCDAGYVL-QGYSTLTCIMGD 1745
Score = 29.3 bits (64), Expect = 8.5
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 5/64 (7%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPGIP N R G F GS C++GF T+ + +G + W IP
Sbjct: 834 CPDPGIPINARR--FGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 891
Query: 114 NSIC 117
+ C
Sbjct: 892 GAPC 895
>gi|110611237 coagulation factor XIII B subunit precursor [Homo
sapiens]
Length = 661
Score = 85.5 bits (210), Expect = 1e-16
Identities = 70/250 (28%), Positives = 104/250 (41%), Gaps = 30/250 (12%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C+ + ENG+ P + EG V +F C + + L G+ C GW P ++ +
Sbjct: 213 CSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-----NFGWYP-ESPV 266
Query: 117 CVQEDCR-----IPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW 171
C R +P + H+ TYRHGE + I C F+I H + +DG W
Sbjct: 267 CEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEI-----HGSAEIRCEDGKW 321
Query: 172 NNLPIC------QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
P C C P NG N+ + G ++Y C G+ L GS + C
Sbjct: 322 TEPPKCIEGQEKVACEEPPFIENGAANLH--SKIYYNGDKVTYACKSGYLLHGSNEITCN 379
Query: 226 QNLIWSSSPPRCLA-LEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDY 284
+ W + PP C+ E C PP+V +G Y G+ VE+ C+ Y L
Sbjct: 380 RGK-W-TLPPECVENNENCKHPPVVMNG--AVADGILASYATGSSVEYRCNEYYLLRGS- 434
Query: 285 KYITCQYGEW 294
K C+ G+W
Sbjct: 435 KISRCEQGKW 444
Score = 47.8 bits (112), Expect = 2e-05
Identities = 68/286 (23%), Positives = 105/286 (36%), Gaps = 68/286 (23%)
Query: 57 CADPGIPENGFRTPSGGV---FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
C P + NG + G+ + GS + C + + L+G+ C + W S
Sbjct: 396 CKHPPVVMNG--AVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQG-----KW--SS 446
Query: 114 NSICVQEDCRIP-------QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
+C+ E C + IE + HG+ + C +G+ DL + L
Sbjct: 447 PPVCL-EPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGY-----DLSPLTPLSE 500
Query: 167 DDGTWNN----LPICQG------CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKL 216
N P+C C P +G + IS ++ G+ + YRCF L
Sbjct: 501 LSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVI-ISSTVDTYENGSSVEYRCFDHHFL 559
Query: 217 DGSAYLECLQNLIWSSSPPRCLALEVCPLP------------------PMVSHG---DFV 255
+GS CL + W++ P L LE C L P + HG +F+
Sbjct: 560 EGSREAYCLDGM-WTTPP---LCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFI 615
Query: 256 CH--PRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQ 299
C P E Y G+++ CD G KY C + SYQ
Sbjct: 616 CRGDTYPAELYITGSILRMQCDRG-----QLKYPRCIPRQSTLSYQ 656
Score = 38.9 bits (89), Expect = 0.011
Identities = 47/191 (24%), Positives = 76/191 (39%), Gaps = 21/191 (10%)
Query: 100 LKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRH---------GEKLIITCHEG 150
LK+ + I S ++ C P +E+ I Y +KL C G
Sbjct: 3 LKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAG 62
Query: 151 FKIRYPDLHNMVSLCRDDGTWNNLPIC-QGCLRPLASSNGYVNISELQTSFPVGTVISYR 209
+ + C +G W+ P C + C +P SNGY IS+++ + + + Y
Sbjct: 63 YTTESGRQEEQTT-CTTEG-WSPEPRCFKKCTKP-DLSNGY--ISDVKLLYKIQENMRYG 117
Query: 210 CFPGFKLDGSAYLECLQNLI--WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHG 267
C G+K G E +Q L WSS P E C L P + +G++ + +
Sbjct: 118 CASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETC-LAPELYNGNYSTTQK---TFKVK 173
Query: 268 TVVEFYCDPGY 278
V++ C GY
Sbjct: 174 DKVQYECATGY 184
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 81.6 bits (200), Expect = 1e-15
Identities = 63/231 (27%), Positives = 103/231 (44%), Gaps = 19/231 (8%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLK--HFNGTLGWIPSDNSI-CVQEDCRIPQIEDAE 131
F GS +F CQ G++++G C+ H++ L P+ +I C + + D
Sbjct: 344 FAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPL---PTCEAISCEPLESPVHGSMDCS 400
Query: 132 IHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQG--CLRPLASSN 188
+ +++ C EGF +R D+ C + G W P+CQ C +
Sbjct: 401 PSLRAFQYDTNCSFRCAEGFMLRGADIVR----CDNLGQWTAPAPVCQALQCQDLPVPNE 456
Query: 189 GYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPM 248
VN S +F +V S+ C G L G++ L+CL W+S PP C A+ P P+
Sbjct: 457 ARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAI---PCTPL 513
Query: 249 VS--HGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPS 297
+S +G C +P ++ + +F CD GYSL+ + + G W S
Sbjct: 514 LSPQNGTMTC-VQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDS 563
Score = 81.3 bits (199), Expect = 2e-15
Identities = 63/230 (27%), Positives = 97/230 (42%), Gaps = 19/230 (8%)
Query: 73 GVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDC---RIPQIED 129
G F S FHC DG+++ G +K CL G + C+ C +IP+ +
Sbjct: 218 GNFSFNSQCSFHCTDGYQVNGPSKLECLAS-----GIWTNKPPQCLAAQCPPLKIPERGN 272
Query: 130 AE-IHN-KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQG--CLRPL 184
+H+ K ++H +C EGF + P+ V C G W P+C+ C
Sbjct: 273 MTCLHSAKAFQHQSSCSFSCEEGFALVGPE----VVQCTASGVWTAPAPVCKAVQCQHLE 328
Query: 185 ASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCP 244
A S G ++ T+F G+ + C PG+++ G L C+ + WS+ P C A+ P
Sbjct: 329 APSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEP 388
Query: 245 LPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
L V HG C P + + T F C G+ L G+W
Sbjct: 389 LESPV-HGSMDCSP-SLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQW 436
Score = 73.2 bits (178), Expect = 5e-13
Identities = 60/236 (25%), Positives = 94/236 (39%), Gaps = 23/236 (9%)
Query: 73 GVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAE- 131
G F SV F C +G L GA+ CL G +P + PQ
Sbjct: 466 GAFRYQSVCSFTCNEGLLLVGASVLQCLA--TGNWNSVPPECQAIPCTPLLSPQNGTMTC 523
Query: 132 ---IHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQG--CLRPLA 185
+ + +Y+ + I C EG+ + P+ + C G W + P +C+ C A
Sbjct: 524 VQPLGSSSYKSTCQFI--CDEGYSLSGPERLD----CTRSGRWTDSPPMCEAIKCPELFA 577
Query: 186 SSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPL 245
G ++ S+ + F VG+ + C GFKL+G +EC + WS++PP C + P
Sbjct: 578 PEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPT 637
Query: 246 PPM-------VSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
P + G C P + T F C+ G++L D G+W
Sbjct: 638 PGVQCPALTTPGQGTMYCRHHP-GTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQW 692
Score = 72.0 bits (175), Expect = 1e-12
Identities = 61/234 (26%), Positives = 94/234 (40%), Gaps = 19/234 (8%)
Query: 69 TPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCR-IPQI 127
+PS F + F C +GF L+GA C LG + +C C+ +P
Sbjct: 400 SPSLRAFQYDTNCSFRCAEGFMLRGADIVRC-----DNLGQWTAPAPVCQALQCQDLPVP 454
Query: 128 EDAEIHNK----TYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL-PICQG--C 180
+A ++ +R+ TC+EG + + V C G WN++ P CQ C
Sbjct: 455 NEARVNCSHPFGAFRYQSVCSFTCNEGLLL----VGASVLQCLATGNWNSVPPECQAIPC 510
Query: 181 LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
L+ NG + + S + + C G+ L G L+C ++ W+ SPP C A+
Sbjct: 511 TPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAI 570
Query: 241 EVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
+ CP G C E +N G+ F CD G+ L G W
Sbjct: 571 K-CPELFAPEQGSLDCSDTRGE-FNVGSTCHFSCDNGFKLEGPNNVECTTSGRW 622
Score = 62.4 bits (150), Expect = 9e-10
Identities = 66/248 (26%), Positives = 93/248 (37%), Gaps = 21/248 (8%)
Query: 57 CADPGIPENGFRT--PSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN 114
C IPE G T S F S F C++GF L G C G +
Sbjct: 262 CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCT-----ASGVWTAPA 316
Query: 115 SICVQEDCRIPQIEDAE----IHNKT-YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDG 169
+C C+ + +H T + +G C G+++R D+ C D G
Sbjct: 317 PVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLR----CIDSG 372
Query: 170 TWN-NLPICQG-CLRPLASS-NGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ 226
W+ LP C+ PL S +G ++ S +F T S+RC GF L G+ + C
Sbjct: 373 HWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDN 432
Query: 227 NLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKY 286
W++ P C AL+ LP HP RY +V F C+ G L
Sbjct: 433 LGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQ--SVCSFTCNEGLLLVGASVL 490
Query: 287 ITCQYGEW 294
G W
Sbjct: 491 QCLATGNW 498
Score = 56.6 bits (135), Expect = 5e-08
Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 2/104 (1%)
Query: 191 VNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVS 250
+N S +F + S+ C G++++G + LECL + IW++ PP+CLA + CP +
Sbjct: 211 MNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQ-CPPLKIPE 269
Query: 251 HGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
G+ C + + H + F C+ G++L G W
Sbjct: 270 RGNMTC-LHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVW 312
Score = 53.1 bits (126), Expect = 5e-07
Identities = 69/306 (22%), Positives = 116/306 (37%), Gaps = 41/306 (13%)
Query: 63 PENGFRT---PSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQ 119
P+NG T P G ++ S +F C +G+ L G + C + T +S +
Sbjct: 516 PQNGTMTCVQPLGSSSYK-STCQFICDEGYSLSGPERLDCTRSGRWT-------DSPPMC 567
Query: 120 EDCRIPQIE-------DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN 172
E + P++ D + G +C GFK+ P N V C G W+
Sbjct: 568 EAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGP---NNVE-CTTSGRWS 623
Query: 173 NLP-ICQG----------CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
P C+G C G + +F T + C GF L G +
Sbjct: 624 ATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDST 683
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLT 281
L C + W++ P C A++ L V+ + +++G++ F+C G L
Sbjct: 684 LSCRPSGQWTAVTPACRAVKCSEL--HVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLN 741
Query: 282 SDYKYITCQYGEWFPSYQVYCIKSEQTWPSTHETLLTTW-KIVAFTATSVLLVLLLVILA 340
+ + G W + + + Q P T + LT + VA T ++ LL +L
Sbjct: 742 GSAQTACQENGHWSTT-----VPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLR 796
Query: 341 RMFQTK 346
+ F+ K
Sbjct: 797 KRFRQK 802
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 78.2 bits (191), Expect = 2e-14
Identities = 68/246 (27%), Positives = 103/246 (41%), Gaps = 28/246 (11%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
VC DPGIP +G R G F G+V RF C+ G L+G+++R C NG+ W S
Sbjct: 2834 VCGDPGIPAHGIRL--GDSFDPGTVMRFSCEAGHVLRGSSERTC--QANGS--WSGSQPE 2887
Query: 116 ICVQEDCRIPQIED--AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN 173
C C P + + ++ C EG Y + C +GTW
Sbjct: 2888 -CGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREG----YYATGLLSRHCSVNGTWTG 2942
Query: 174 L-PICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGS--AYLECLQNL 228
P C C P +NG L F ++Y+C PG+ ++ + L C ++
Sbjct: 2943 SDPECLVINCGDPGIPANGL----RLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDR 2998
Query: 229 IWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYIT 288
W+ + P C AL +C PP++ +G V + G+ V + C GY L+ +
Sbjct: 2999 TWNGTKPVCKAL-MCKPPPLIPNGKVV-----GSDFMWGSSVTYACLEGYQLSLPAVFTC 3052
Query: 289 CQYGEW 294
G W
Sbjct: 3053 EGNGSW 3058
Score = 77.0 bits (188), Expect = 4e-14
Identities = 68/245 (27%), Positives = 112/245 (45%), Gaps = 28/245 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C + IP NG R + V+ G+ A F C G+ L G+ R C+ NG W S+
Sbjct: 2658 CGELPIPPNGHRIGTLSVY--GATAIFSCNSGYTLVGSRVRECMA--NGL--WSGSEVR- 2710
Query: 117 CVQEDCRIPQ-IEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-L 174
C+ C P+ I + I+ + Y + ++ C+ GF++ + V +C+ D W+
Sbjct: 2711 CLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRL----IGMSVRICQQDHHWSGKT 2766
Query: 175 PICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSS 232
P C C P + + ++ S+ VG V+ Y C L G++ C + W+
Sbjct: 2767 PFCVLVSCGHPGSPPHSQMS----GDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTG 2822
Query: 233 SPPRC--LALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
S P C ++ VC P + +HG R + ++ GTV+ F C+ G+ L + TCQ
Sbjct: 2823 SLPHCSGTSVGVCGDPGIPAHG-----IRLGDSFDPGTVMRFSCEAGHVLRGSSER-TCQ 2876
Query: 291 -YGEW 294
G W
Sbjct: 2877 ANGSW 2881
Score = 69.7 bits (169), Expect = 6e-12
Identities = 61/247 (24%), Positives = 99/247 (40%), Gaps = 27/247 (10%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C P + NG G F GS + C +G++L C + + T G +P
Sbjct: 3011 MCKPPPLIPNG--KVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWT-GELPQ--- 3064
Query: 116 ICVQEDCRIPQIED-AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
C C P + ++ + + + +CH + + + C+ DGTW+
Sbjct: 3065 -CFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVL----VGSPRRFCQSDGTWSGT 3119
Query: 175 ------PICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL 228
P C P G N S+ + VG+ + +RC G+ L GS CL NL
Sbjct: 3120 QPSCIDPTLTTCADPGVPQFGIQNNSQ---GYQVGSTVLFRCQKGYLLQGSTTRTCLPNL 3176
Query: 229 IWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYIT 288
WS +PP C+ C P +H + P + G + + C G+SL ++ T
Sbjct: 3177 TWSGTPPDCVP-HHCRQPETPTHANVGALDLP----SMGYTLIYSCQEGFSLKGGSEHRT 3231
Query: 289 CQY-GEW 294
C+ G W
Sbjct: 3232 CKADGSW 3238
Score = 66.6 bits (161), Expect = 5e-11
Identities = 47/127 (37%), Positives = 61/127 (48%), Gaps = 12/127 (9%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
L CADPG+P+ G + S G + GS F CQ G+ L+G+T R CL N T P D
Sbjct: 3128 LTTCADPGVPQFGIQNNSQG-YQVGSTVLFRCQKGYLLQGSTTRTCLP--NLTWSGTPPD 3184
Query: 114 NSICVQEDCRIPQI-EDAEIHNKTY-RHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW 171
CV CR P+ A + G LI +C EGF ++ H C+ DG+W
Sbjct: 3185 ---CVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSEHR---TCKADGSW 3238
Query: 172 NNL-PIC 177
PIC
Sbjct: 3239 TGKPPIC 3245
Score = 65.1 bits (157), Expect = 1e-10
Identities = 60/257 (23%), Positives = 98/257 (38%), Gaps = 22/257 (8%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C+ P P +GF GS+ F C G++L G + +C +H G W + +
Sbjct: 2468 CSLPRAPLHGFILGQTSTQPGGSI-HFGCNAGYRLVGHSMAICTRHPQGYHLWSEA-IPL 2525
Query: 117 CVQEDCRIPQI-EDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP 175
C C +P+ ++ + K Y G K + +C EG+ ++ + C D G W+N
Sbjct: 2526 CQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAG--AEATAECLDTGLWSNRN 2583
Query: 176 ICQGCLRPLASSNGYVNISE------LQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
+ C+ +++ +T + + C PG+ G + C N
Sbjct: 2584 VPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGK 2643
Query: 230 WS--SSPPRCLALEVCPLP-PMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKY 286
WS S P C + LP P H R +G F C+ GY+L
Sbjct: 2644 WSLGDSTPTCRIISCGELPIPPNGH-------RIGTLSVYGATAIFSCNSGYTLVGSRVR 2696
Query: 287 ITCQYGEWFPSYQVYCI 303
G W S +V C+
Sbjct: 2697 ECMANGLWSGS-EVRCL 2712
Score = 61.2 bits (147), Expect = 2e-09
Identities = 51/189 (26%), Positives = 83/189 (43%), Gaps = 19/189 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTL-GWIPS--D 113
C DPG+P G R G F S F C L G+ +R C +GT G PS D
Sbjct: 3070 CGDPGVPSRGRREDRG--FSYRSSVSFSCHPPLVLVGSPRRFCQS--DGTWSGTQPSCID 3125
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN 173
++ D +PQ + +++ Y+ G ++ C +G+ ++ + C + TW+
Sbjct: 3126 PTLTTCADPGVPQF-GIQNNSQGYQVGSTVLFRCQKGYLLQ----GSTTRTCLPNLTWSG 3180
Query: 174 LP---ICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDG-SAYLECLQNLI 229
P + C +P ++ V +L + +G + Y C GF L G S + C +
Sbjct: 3181 TPPDCVPHHCRQPETPTHANVGALDLPS---MGYTLIYSCQEGFSLKGGSEHRTCKADGS 3237
Query: 230 WSSSPPRCL 238
W+ PP CL
Sbjct: 3238 WTGKPPICL 3246
Score = 55.1 bits (131), Expect = 1e-07
Identities = 62/262 (23%), Positives = 100/262 (38%), Gaps = 37/262 (14%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL--CLKHFNGTLGWIPSDN 114
C P P+NG G + G+ A + C +G+ L+ + CL + +P
Sbjct: 2531 CGLPEAPKNGM--VFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQ- 2587
Query: 115 SICVQEDCRIPQIEDAEIHN--------KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
CV C P + + + Y+ +L++ C G Y V C+
Sbjct: 2588 --CVPVTC--PDVSSISVEHGRWRLIFETQYQFQAQLMLICDPG----YYYTGQRVIRCQ 2639
Query: 167 DDGTWN---NLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
+G W+ + P C+ C NG+ + T G + C G+ L GS
Sbjct: 2640 ANGKWSLGDSTPTCRIISCGELPIPPNGH----RIGTLSVYGATAIFSCNSGYTLVGSRV 2695
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLT 281
EC+ N +WS S RCLA C P + +G E Y++ V + C+ G+ L
Sbjct: 2696 RECMANGLWSGSEVRCLAGH-CGTPEPIVNGHI-----NGENYSYRGSVVYQCNAGFRLI 2749
Query: 282 SDYKYITCQYGEWFPSYQVYCI 303
I CQ + +C+
Sbjct: 2750 GMSVRI-CQQDHHWSGKTPFCV 2770
Score = 48.1 bits (113), Expect = 2e-05
Identities = 63/242 (26%), Positives = 93/242 (38%), Gaps = 67/242 (27%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLK-------------- 101
+C DPGIPE G R G F GS +F C +G+ L+G+ + C+K
Sbjct: 342 MCPDPGIPERGKRL--GSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPV 399
Query: 102 --------HFNGTLGWIPS--------DNSICV-----QEDCRIPQIE----DAEIHNKT 136
H G G I S +N+ CV ++ ++ D E T
Sbjct: 400 CRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDT 459
Query: 137 YRHG-------EKLIITCHEGFKIRYPDL-----HNMVSLCRDDGTWNNL-------PIC 177
G +K ++ G + PDL H M L + DG+ ++L I
Sbjct: 460 LTVGDGGQDGDQKTVLYILTGTSV--PDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIE 517
Query: 178 QG-CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPR 236
QG C P + G S F G + + C P F+L G + C +N WS+ P
Sbjct: 518 QGSCGDPGIPAYGRREGSR----FHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPG 573
Query: 237 CL 238
C+
Sbjct: 574 CV 575
Score = 46.6 bits (109), Expect = 5e-05
Identities = 19/42 (45%), Positives = 30/42 (71%), Gaps = 2/42 (4%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA 239
F VG +++ CFPG++L+G+A + CL + +WSS PRC+A
Sbjct: 1055 FGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVA 1096
Score = 42.7 bits (99), Expect = 7e-04
Identities = 22/62 (35%), Positives = 33/62 (53%), Gaps = 6/62 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPPRC 237
C P SNG V E + V V+S++C PG+ L G A++ C+ + W+ PP C
Sbjct: 1909 CPEPAVPSNG-VKTGE---RYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC 1964
Query: 238 LA 239
+A
Sbjct: 1965 IA 1966
Score = 41.2 bits (95), Expect = 0.002
Identities = 63/279 (22%), Positives = 88/279 (31%), Gaps = 101/279 (36%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKG--------ATKR-------L 98
L C +P +P NG +T G + V F C+ G+ L+G T R L
Sbjct: 1906 LSSCPEPAVPSNGVKT--GERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPL 1963
Query: 99 CLKHFNGTL-------------GWIPSDNSICVQEDCRI--------------PQIEDAE 131
C+ GT+ G PS+ + + P + E
Sbjct: 1964 CIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIE 2023
Query: 132 IHNKTYRHGE------------KLIITCHE--------------GFKIRYPDL---HNMV 162
I N Y L+ T HE GFK+ Y DL H +
Sbjct: 2024 IRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQIS 2083
Query: 163 SLCRD-----------------DGTWNNLPIC-----QGCLRPLASSNGYVNISELQTSF 200
S R W+ P C Q C P +NG V +
Sbjct: 2084 SFLRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVR----GAGY 2139
Query: 201 PVGTVISYRCFPGFKLDGSAYLECLQ--NLIWSSSPPRC 237
VG +++ C PG++L G L C N W P+C
Sbjct: 2140 NVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKC 2178
Score = 40.8 bits (94), Expect = 0.003
Identities = 19/48 (39%), Positives = 27/48 (56%), Gaps = 1/48 (2%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L C DPG P+ G++ G F GS F C G+ L+G+ + LCL
Sbjct: 1207 ELIKCEDPGTPKFGYKVHDEG-HFAGSSVSFSCDPGYSLRGSEELLCL 1253
Score = 40.8 bits (94), Expect = 0.003
Identities = 22/56 (39%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPS 112
C DPGIP+NG R SG + G F C G+ L+G+ + C+K W PS
Sbjct: 1385 CNDPGIPQNGSR--SGDSWEAGDSTVFQCDPGYALQGSAEISCVK-IENRFFWQPS 1437
Score = 39.3 bits (90), Expect = 0.008
Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 3/61 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPGIP NG R G F+ G++ F C G+ L C +F + +PS ++
Sbjct: 867 CLDPGIPVNGQR--HGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRA-LPSCEAL 923
Query: 117 C 117
C
Sbjct: 924 C 924
Score = 38.9 bits (89), Expect = 0.011
Identities = 52/238 (21%), Positives = 90/238 (37%), Gaps = 30/238 (12%)
Query: 62 IPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQED 121
+PE + G F G++ RF C G+ L+G+ + CL W S + V
Sbjct: 1738 VPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCG 1797
Query: 122 CRIPQIEDA-------EIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
+ + E + + K+++ G +I+ +VS + W++L
Sbjct: 1798 GNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQ------VVSFVTEQN-WDSL 1850
Query: 175 PICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSP 234
+ G N + SF TV + +L Y + +
Sbjct: 1851 EVFDGA----------DNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLE 1900
Query: 235 PRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYG 292
+ + L CP P + S+G + ERY VV F C+PGY+L + +I+C G
Sbjct: 1901 YKTVGLSSCPEPAVPSNG-----VKTGERYLVNDVVSFQCEPGYAL-QGHAHISCMPG 1952
Score = 38.1 bits (87), Expect = 0.018
Identities = 18/51 (35%), Positives = 26/51 (50%), Gaps = 3/51 (5%)
Query: 192 NISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ---NLIWSSSPPRCLA 239
N S S+ G ++C PG+ L GSA + C++ W SPP C+A
Sbjct: 1393 NGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIA 1443
Score = 37.4 bits (85), Expect = 0.031
Identities = 26/91 (28%), Positives = 36/91 (39%), Gaps = 19/91 (20%)
Query: 150 GFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYR 209
GF++RY + C D G +P VN F VG ++++
Sbjct: 852 GFQLRYETITLQSDHCLDPG----IP---------------VNGQRHGNDFYVGALVTFS 892
Query: 210 CFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
C G+ L LEC N WS + P C AL
Sbjct: 893 CDSGYTLSDGEPLECEPNFQWSRALPSCEAL 923
Score = 35.4 bits (80), Expect = 0.12
Identities = 33/103 (32%), Positives = 44/103 (42%), Gaps = 11/103 (10%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECLQN--LIWSSSPPRCLALEV-CPLPPMV--SHGDF 254
F +G ++ YRC PGF L G+ L C L + PP C EV CP ++ S G
Sbjct: 2312 FNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPIC---EVHCPTNELLTDSTGVI 2368
Query: 255 VCHPRPCERYNHGT---VVEFYCDPGYSLTSDYKYITCQYGEW 294
+ P T +V D SLT +Y QY E+
Sbjct: 2369 LSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEF 2411
Score = 32.7 bits (73), Expect = 0.77
Identities = 23/60 (38%), Positives = 29/60 (48%), Gaps = 8/60 (13%)
Query: 235 PRCLALEV--CPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYG 292
P C A E+ CP P ++G YN G V F C PGY LT + +TCQ+G
Sbjct: 2113 PGCEAYELQECPDPEPFANGIV-----RGAGYNVGQSVTFECLPGYQLTG-HPVLTCQHG 2166
Score = 32.3 bits (72), Expect = 1.0
Identities = 16/48 (33%), Positives = 23/48 (47%), Gaps = 2/48 (4%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
DL+ C +P +P R G F G F C G++L+G + CL
Sbjct: 1035 DLEPCEEPEVPAYSIR--KGLQFGVGDTLTFSCFPGYRLEGTARITCL 1080
Score = 32.3 bits (72), Expect = 1.0
Identities = 15/66 (22%), Positives = 34/66 (51%), Gaps = 8/66 (12%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL----QNLIWSSS 233
+ C P + NG + + + +G+ ++Y C G++++G++ L C+ +W++
Sbjct: 1556 ESCFDPGSIKNG----TRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNP 1611
Query: 234 PPRCLA 239
P C A
Sbjct: 1612 RPVCTA 1617
Score = 32.0 bits (71), Expect = 1.3
Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 2/39 (5%)
Query: 203 GTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA 239
G+ +S+ C PG+ L GS L CL + W P C+A
Sbjct: 1231 GSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVA 1269
Score = 30.0 bits (66), Expect = 5.0
Identities = 16/50 (32%), Positives = 23/50 (46%), Gaps = 4/50 (8%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLEC----LQNLIWSSSPPRCLALEVC 243
++F +G + Y C GF L+G A L C + W P C A + C
Sbjct: 153 STFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDAC 202
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 76.6 bits (187), Expect = 5e-14
Identities = 64/242 (26%), Positives = 99/242 (40%), Gaps = 22/242 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +PG P NG S G+ F SV + C +G+K G R C NGT D
Sbjct: 2979 CGNPGTPTNGMIVSSDGILFSSSVI-YACWEGYKTSGLMTRHCTA--NGTWTGTAPD--- 3032
Query: 117 CVQEDCRIP-QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NL 174
C C P + + + + + C+ G+ + + + C DG WN +
Sbjct: 3033 CTIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVME--AVTSATIRCTKDGRWNPSK 3090
Query: 175 PICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSS 232
P+C+ C +P NG V S+ F G+ ISY C G++L SA L C +W
Sbjct: 3091 PVCKAVLCPQPPPVQNGTVEGSD----FRWGSSISYSCMDGYQLSHSAILSCEGRGVWKG 3146
Query: 233 SPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYG 292
P+CL + C P + + G + + + + V F C + L + + G
Sbjct: 3147 EIPQCLPV-FCGDPGIPAEGRL-----SGKSFTYKSEVFFQCKSPFILVGSSRRVCQADG 3200
Query: 293 EW 294
W
Sbjct: 3201 TW 3202
Score = 74.3 bits (181), Expect = 2e-13
Identities = 58/239 (24%), Positives = 96/239 (40%), Gaps = 20/239 (8%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C P +NG T G F GS + C DG++L + C G W +
Sbjct: 3097 LCPQPPPVQNG--TVEGSDFRWGSSISYSCMDGYQLSHSAILSC----EGRGVW-KGEIP 3149
Query: 116 ICVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
C+ C P I + + K++ + ++ C F + + + +C+ DGTW+ +
Sbjct: 3150 QCLPVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFIL----VGSSRRVCQADGTWSGI 3205
Query: 175 -PICQGCLRPLASSNG--YVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
P C G + I + VG+ + +RC G+ + GS CL NL WS
Sbjct: 3206 QPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWS 3265
Query: 232 SSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
C+ C P +H D R + G + + C PG+ L ++ TC+
Sbjct: 3266 GIQTECIP-HACRQPETPAHADV----RAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCK 3319
Score = 71.6 bits (174), Expect = 1e-12
Identities = 66/246 (26%), Positives = 101/246 (41%), Gaps = 28/246 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P NG SG F + C GF+L G + R+CL+ + +
Sbjct: 2681 CGSPDPIVNGHI--SGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWS-----GQTPV 2733
Query: 117 CVQEDCRIPQIEDAEIHNKT-YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-L 174
CV C P N + + + + TC+ G+ ++ + CR +G W++ L
Sbjct: 2734 CVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSR----AQCRSNGQWSSPL 2789
Query: 175 PICQ--GCLRP----LASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL 228
P C+ C P A +G N E SF G I Y C GF L GS+ L C+ N
Sbjct: 2790 PTCRVVNCSDPGFVENAIRHGQQNFPE---SFEYGMSILYHCKKGFYLLGSSALTCMANG 2846
Query: 229 IWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYIT 288
+W S P+CLA+ C P + ++ E + +G VV + C SL + +
Sbjct: 2847 LWDRSLPKCLAIS-CGHPGVPANAVLT-----GELFTYGAVVHYSCRGSESLIGNDTRVC 2900
Query: 289 CQYGEW 294
+ W
Sbjct: 2901 QEDSHW 2906
Score = 67.4 bits (163), Expect = 3e-11
Identities = 67/284 (23%), Positives = 105/284 (36%), Gaps = 76/284 (26%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIE-DAEIHNKT 136
GS + C+ G+++ G + C ++ G W S +C C IP+ +
Sbjct: 2453 GSKVHYFCKPGYRMVGHSNATCRRNPLGMYQW-DSLTPLCQAVSCGIPESPGNGSFTGNE 2511
Query: 137 YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL---PICQGCLRP---------- 183
+ K++ CHEGFK+ ++C++DG W+N P C+ P
Sbjct: 2512 FTLDSKVVYECHEGFKLE--SSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHV 2569
Query: 184 -----------------LASSNGYV---------------NISELQTS----------FP 201
L+ S GY NI + + S FP
Sbjct: 2570 IWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFP 2629
Query: 202 -----VGTVISY------RCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVS 250
+GT+ Y C G+ L GS ECL N +WS S RCLA C P +
Sbjct: 2630 PNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGH-CGSPDPIV 2688
Query: 251 HGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
+G + +++ V + C+PG+ L I Q +W
Sbjct: 2689 NGHI-----SGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKW 2727
Score = 61.2 bits (147), Expect = 2e-09
Identities = 58/211 (27%), Positives = 90/211 (42%), Gaps = 28/211 (13%)
Query: 57 CADPGIPENGFRTPSGGV---FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
C+DPG EN R F G +HC+ GF L G++ C+ NG W D
Sbjct: 2797 CSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMA--NGL--W---D 2849
Query: 114 NSI--CVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
S+ C+ C P + +A + + + +G + +C + + N +C++D
Sbjct: 2850 RSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESL----IGNDTRVCQEDSH 2905
Query: 171 WNN-LPICQG-----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
W+ LP C G C P ++G S L F +++ + C G +L GS C
Sbjct: 2906 WSGALPHCTGNNPGFCGDPGTPAHG----SRLGDDFKTKSLLRFSCEMGHQLRGSPERTC 2961
Query: 225 LQNLIWSSSPPRCLALEVCPLPPMVSHGDFV 255
L N WS P C A+ C P ++G V
Sbjct: 2962 LLNGSWSGLQPVCEAVS-CGNPGTPTNGMIV 2991
Score = 40.8 bits (94), Expect = 0.003
Identities = 24/54 (44%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGF-KLKGATKRLCLKHFNGTLGW 109
C DPGIP NG R G F GS FHC DGF K +G+ C+ +G + W
Sbjct: 698 CHDPGIPINGRRF--GDRFLLGSSVSFHCDDGFVKTQGSESITCILQ-DGNVVW 748
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/141 (26%), Positives = 58/141 (41%), Gaps = 33/141 (23%)
Query: 146 TCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTV 205
T +GFKIRY P C PL + G +N +T+ VG+
Sbjct: 2419 TSKKGFKIRYA-----------------APYCS-LTHPL-KNGGILN----RTAGAVGSK 2455
Query: 206 ISYRCFPGFKLDGSAYLECLQNLI----WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPC 261
+ Y C PG+++ G + C +N + W S P C A+ C +P +G F +
Sbjct: 2456 VHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVS-CGIPESPGNGSFTGN---- 2510
Query: 262 ERYNHGTVVEFYCDPGYSLTS 282
+ + V + C G+ L S
Sbjct: 2511 -EFTLDSKVVYECHEGFKLES 2530
Score = 39.3 bits (90), Expect = 0.008
Identities = 17/42 (40%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA 239
F VG +++ CF G++L+G+ L CL +WS+ PRC+A
Sbjct: 1062 FGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVA 1103
Score = 39.3 bits (90), Expect = 0.008
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 1/55 (1%)
Query: 46 QLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
QLT DL C DPGIP G+R G F +V + C G+ + G+ CL
Sbjct: 1207 QLTYTSFDLVKCEDPGIPNYGYRIRDEG-HFTDTVVLYSCNPGYAMHGSNTLTCL 1260
Score = 39.3 bits (90), Expect = 0.008
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 4/62 (6%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPG+P+NG T G G F C G++L+G K C++ N W P D
Sbjct: 1392 CNDPGMPQNG--TRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQ-LNNRFFWQP-DPPT 1447
Query: 117 CV 118
C+
Sbjct: 1448 CI 1449
Score = 39.3 bits (90), Expect = 0.008
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 6/62 (9%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ--NLIWSSSPP 235
Q C P NGY+ + + + VG +S+ C+PG+ L G L C N W+ P
Sbjct: 2086 QNCPDPPPFQNGYM----INSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFP 2141
Query: 236 RC 237
RC
Sbjct: 2142 RC 2143
Score = 38.9 bits (89), Expect = 0.011
Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 56 VCADPGIPENGFRTPSGGVFFE-GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN 114
+C DPGIPENG R +G F G+ +F C+D + L+G+ C + W
Sbjct: 348 MCPDPGIPENGRR--AGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAW-SDHR 404
Query: 115 SICVQEDC 122
IC C
Sbjct: 405 PICRARTC 412
Score = 38.9 bits (89), Expect = 0.011
Identities = 21/48 (43%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
DL+ C DPG+P F G F G F C G++L+GATK CL
Sbjct: 1042 DLEPCDDPGVP--AFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCL 1087
Score = 38.5 bits (88), Expect = 0.014
Identities = 14/40 (35%), Positives = 23/40 (57%), Gaps = 3/40 (7%)
Query: 203 GTVISYRCFPGFKLDGSAYLECLQ---NLIWSSSPPRCLA 239
G ++++C PG++L G A + C+Q W PP C+A
Sbjct: 1411 GDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIA 1450
Score = 38.1 bits (87), Expect = 0.018
Identities = 59/245 (24%), Positives = 91/245 (37%), Gaps = 44/245 (17%)
Query: 62 IPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSDNSIC- 117
+PE + G F GS+ RF C G+ L+G+T C N W IPS C
Sbjct: 1745 VPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPCS 1804
Query: 118 ---VQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
Q I E + K+I+T G +I+ ++S + W++L
Sbjct: 1805 GNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQ------VISFATEQ-NWDSL 1857
Query: 175 PICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSA-----YLECLQN 227
I G P S + L S S + + F+ D S +LE
Sbjct: 1858 EIHDGGDVTAPRLGSFSGTTVPALLNS------TSNQLYLHFQSDISVAAAGFHLEY--- 1908
Query: 228 LIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYI 287
+ + L C P + S+ + +RY V+ F C+PGY+L +I
Sbjct: 1909 --------KTVGLAACQEPALPSNSIKI-----GDRYMVNDVLSFQCEPGYTL-QGRSHI 1954
Query: 288 TCQYG 292
+C G
Sbjct: 1955 SCMPG 1959
Score = 37.7 bits (86), Expect = 0.024
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 23/108 (21%)
Query: 134 NKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNI 193
N+ Y H + I GF + Y + L CQ P SN
Sbjct: 1887 NQLYLHFQSDISVAAAGFHLEYKTV--------------GLAACQ---EPALPSNSI--- 1926
Query: 194 SELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPPRCLA 239
++ + V V+S++C PG+ L G +++ C+ + W+ P C+A
Sbjct: 1927 -KIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIA 1973
Score = 37.0 bits (84), Expect = 0.041
Identities = 59/252 (23%), Positives = 91/252 (36%), Gaps = 46/252 (18%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
L C +P +P N + G + V F C+ G+ L+G + C+ GT+
Sbjct: 1913 LAACQEPALPSNSIKI--GDRYMVNDVLSFQCEPGYTLQGRSHISCMP---GTVRRWNYP 1967
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN- 172
+ +C+ A G ++ GF YP+ N+ D TW
Sbjct: 1968 SPLCI-----------ATCGGTLSTLGGVIL---SPGFPGSYPN--NL------DCTWRI 2005
Query: 173 NLPICQGCLRPLASSNGYVNISELQT-SFPVGTVISYRCFPGFKLDGSA----------- 220
+LPI G + + N L+ + P T F G L +
Sbjct: 2006 SLPIGYGAHIQFLNFSTEANHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHF 2065
Query: 221 YLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
Y + QN + L+ CP PP +G + Y+ G V F C PGY L
Sbjct: 2066 YSDHSQNRQGFKLAYQAYELQNCPDPPPFQNGYMINSD-----YSVGQSVSFECYPGYIL 2120
Query: 281 TSDYKYITCQYG 292
+ +TCQ+G
Sbjct: 2121 IG-HPVLTCQHG 2131
Score = 35.8 bits (81), Expect = 0.091
Identities = 18/50 (36%), Positives = 22/50 (44%), Gaps = 4/50 (8%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECL----QNLIWSSSPPRCLALEVC 243
T F +G I Y C PG+ L+G A L C+ W P C A C
Sbjct: 159 TRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGAC 208
Score = 35.8 bits (81), Expect = 0.091
Identities = 18/44 (40%), Positives = 27/44 (61%), Gaps = 4/44 (9%)
Query: 200 FPVGTVISYRCFPGF-KLDGSAYLECLQ---NLIWSSSPPRCLA 239
F +G+ +S+ C GF K GS + C+ N++WSS+ PRC A
Sbjct: 714 FLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEA 757
Score = 35.8 bits (81), Expect = 0.091
Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 3/61 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPGIP NG R GG F S F C G+ L +C ++ +PS +++
Sbjct: 874 CLDPGIPVNGHR--HGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHA-LPSCDAL 930
Query: 117 C 117
C
Sbjct: 931 C 931
Score = 34.7 bits (78), Expect = 0.20
Identities = 18/43 (41%), Positives = 19/43 (44%), Gaps = 2/43 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLC 99
C DPGIP G RT G F G F C F+L G C
Sbjct: 528 CGDPGIPAYGKRT--GSSFLHGDTLTFECPAAFELVGERVITC 568
Score = 34.7 bits (78), Expect = 0.20
Identities = 21/66 (31%), Positives = 30/66 (45%), Gaps = 5/66 (7%)
Query: 55 QVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IP 111
+ C DPG NG R G F GS + C G+K+ + C+ +G W +P
Sbjct: 1563 EACFDPGNIMNGTRV--GTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLP 1620
Query: 112 SDNSIC 117
S N+ C
Sbjct: 1621 SCNAPC 1626
Score = 34.3 bits (77), Expect = 0.26
Identities = 24/85 (28%), Positives = 38/85 (44%), Gaps = 12/85 (14%)
Query: 204 TVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA-----LEVCPLPPMVSHGDFVC 256
TV+ Y C PG+ + GS L CL +W P C+A + ++S G
Sbjct: 1239 TVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAECGGQIHAATSGRILSPG---- 1294
Query: 257 HPRPCERYNHGTVVEFYCDPGYSLT 281
+P P + H T + DPG +++
Sbjct: 1295 YPAPYDNNLHCTWI-IEADPGKTIS 1318
Score = 33.9 bits (76), Expect = 0.34
Identities = 14/41 (34%), Positives = 22/41 (53%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
+SF G +++ C F+L G + C QN WS + P C+
Sbjct: 542 SSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCV 582
Score = 33.1 bits (74), Expect = 0.59
Identities = 18/61 (29%), Positives = 30/61 (49%), Gaps = 4/61 (6%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLA 239
CL P NG+ + + F + + +++ C PG+ L L C +N W+ + P C A
Sbjct: 874 CLDPGIPVNGHRHGGD----FGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDA 929
Query: 240 L 240
L
Sbjct: 930 L 930
Score = 30.8 bits (68), Expect = 2.9
Identities = 17/47 (36%), Positives = 23/47 (48%), Gaps = 4/47 (8%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLEC--LQNLIWSSSPPRCLALEVCP 244
F +G + Y+C PG+ L G+ L C L + S P C A CP
Sbjct: 2277 FEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEA--QCP 2321
Score = 29.6 bits (65), Expect = 6.5
Identities = 16/52 (30%), Positives = 23/52 (44%), Gaps = 9/52 (17%)
Query: 260 PCERYNHG------TVVEFYCDPGYSLTSDYKYITCQYGEW---FPSYQVYC 302
P + HG + V F CDPGY+L+ D + + +W PS C
Sbjct: 880 PVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALC 931
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 75.5 bits (184), Expect = 1e-13
Identities = 67/268 (25%), Positives = 105/268 (39%), Gaps = 33/268 (12%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + F GS + C +GF+L G+ CL N + W I
Sbjct: 1907 CGPPPEPFNGMVHINTDTQF-GSTVNYSCNEGFRLIGSPSTTCLVSGN-NVTW-DKKAPI 1963
Query: 117 CVQEDCR-IPQIEDAEIHNK---TYRHGEKLIITCHEGFKIRYPDLHNMVSL-------- 164
C C P I + + ++ ++ +G + CH G PD + L
Sbjct: 1964 CEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTG-----PDGEQLFELVGERSIYC 2018
Query: 165 -CRDD--GTWNNLP----ICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLD 217
+DD G W++ P C P + + ++ F + +I +RC PGF +
Sbjct: 2019 TSKDDQVGVWSSPPPRCISTNKCTAP--EVENAIRVPGNRSFFTLTEIIRFRCQPGFVMV 2076
Query: 218 GSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPG 277
GS ++C N W P C VC PP + HG+ + + ++ G V + C+P
Sbjct: 2077 GSHTVQCQTNGRWGPKLPHC--SRVCQPPPEILHGEHTLSHQ--DNFSPGQEVFYSCEPS 2132
Query: 278 YSLTSDYKYITCQYGEWFPSYQVYCIKS 305
Y L G+W P +KS
Sbjct: 2133 YDLRGAASLHCTPQGDWSPEAPRCTVKS 2160
Score = 73.6 bits (179), Expect = 4e-13
Identities = 70/282 (24%), Positives = 118/282 (41%), Gaps = 25/282 (8%)
Query: 40 LCFGPAQLTGGFDDLQ--VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKR 97
+C + TG D + C +P P NG G+ F GS ++ C G++L G++
Sbjct: 85 ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQF-GSQIKYSCTKGYRLIGSSSA 143
Query: 98 LCLKHFNGTLGWIPSDNSICVQEDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFKI 153
C+ T+ W ++ IC + C +P + + + + +G + C+ G
Sbjct: 144 TCIIS-GDTVIW-DNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGG 201
Query: 154 RYP-DLHNMVSL---CRDD--GTWNN-LPIC---QGCLRPLASSNGYVNISELQTSFPVG 203
R +L S+ DD G W+ P C C P + + +S+ ++ F +
Sbjct: 202 RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENG--ILVSDNRSLFSLN 259
Query: 204 TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCER 263
V+ +RC PGF + G ++C W P C VC PP V H + R +
Sbjct: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS--RVCQPPPDVLHAERT--QRDKDN 315
Query: 264 YNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKS 305
++ G V + C+PGY L G+W P+ +KS
Sbjct: 316 FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKS 357
Score = 70.9 bits (172), Expect = 3e-12
Identities = 58/230 (25%), Positives = 99/230 (43%), Gaps = 25/230 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 238 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 296
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q + E + + G+++ +C G+ DL S+ C G W+
Sbjct: 297 C-QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-----DLRGAASMRCTPQGDWSPAA 350
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFPV----GTVISYRCFPGFKLDGSAYLECL---Q 226
P C+ + S + ++ + + FPV G + + C GF+L GS+ C+
Sbjct: 351 PTCE-----VKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
Query: 227 NLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDP 276
+W+SS P C + CP PP++ +G +P E + G V + CDP
Sbjct: 406 ESLWNSSVPVCEQI-FCPSPPVIPNGRHT--GKPLEVFPFGKTVNYTCDP 452
Score = 70.9 bits (172), Expect = 3e-12
Identities = 58/230 (25%), Positives = 99/230 (43%), Gaps = 25/230 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 746
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q + E + + G+++ +C G+ DL S+ C G W+
Sbjct: 747 C-QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-----DLRGAASMRCTPQGDWSPAA 800
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFPV----GTVISYRCFPGFKLDGSAYLECL---Q 226
P C+ + S + ++ + + FPV G + + C GF+L GS+ C+
Sbjct: 801 PTCE-----VKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
Query: 227 NLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDP 276
+W+SS P C + CP PP++ +G +P E + G V + CDP
Sbjct: 856 ESLWNSSVPVCEQI-FCPSPPVIPNGRHT--GKPLEVFPFGKTVNYTCDP 902
Score = 70.9 bits (172), Expect = 3e-12
Identities = 58/230 (25%), Positives = 99/230 (43%), Gaps = 25/230 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 1196
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q + E + + G+++ +C G+ DL S+ C G W+
Sbjct: 1197 C-QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-----DLRGAASMRCTPQGDWSPAA 1250
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFPV----GTVISYRCFPGFKLDGSAYLECL---Q 226
P C+ + S + ++ + + FPV G + + C GF+L GS+ C+
Sbjct: 1251 PTCE-----VKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
Query: 227 NLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDP 276
+W+SS P C + CP PP++ +G +P E + G V + CDP
Sbjct: 1306 ESLWNSSVPVCEQI-FCPSPPVIPNGRHT--GKPLEVFPFGKAVNYTCDP 1352
Score = 67.8 bits (164), Expect = 2e-11
Identities = 58/230 (25%), Positives = 96/230 (41%), Gaps = 25/230 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 1646
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q I E H + G+++ +C G+ DL SL C G W+
Sbjct: 1647 C-QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGY-----DLRGAASLHCTPQGDWSPEA 1700
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFP----VGTVISYRCFPGFKLDGSAYLECL---Q 226
P C + S + ++ + + FP +G +S+ C GF+L GS+ C+
Sbjct: 1701 PRC-----AVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
Query: 227 NLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDP 276
+W++S P C + CP PP + +G P +G + + CDP
Sbjct: 1756 RSLWNNSVPVCEHI-FCPNPPAILNGRHT--GTPSGDIPYGKEISYTCDP 1802
Score = 67.0 bits (162), Expect = 4e-11
Identities = 65/263 (24%), Positives = 105/263 (39%), Gaps = 23/263 (8%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + GS + C G +L G + C+ N T W + I
Sbjct: 1454 CKTPPDPVNGMVHVITDIQV-GSRINYSCTTGHRLIGHSSAECILSGN-TAHW-STKPPI 1510
Query: 117 CVQEDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFKIRYP-DLHNMVSL---CRDD 168
C + C +P + + + + +G + C+ G + R +L S+ DD
Sbjct: 1511 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDD 1570
Query: 169 --GTWNN-LPIC---QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYL 222
G W+ P C C P + + +S+ ++ F + V+ +RC PGF + G +
Sbjct: 1571 QVGIWSGPAPQCIIPNKCTPPNVENG--ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 1628
Query: 223 ECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTS 282
+C W P C VC PP + HG+ P + ++ G V + C+PGY L
Sbjct: 1629 KCQALNKWEPELPSCS--RVCQPPPEILHGEHT--PSHQDNFSPGQEVFYSCEPGYDLRG 1684
Query: 283 DYKYITCQYGEWFPSYQVYCIKS 305
G+W P +KS
Sbjct: 1685 AASLHCTPQGDWSPEAPRCAVKS 1707
Score = 62.4 bits (150), Expect = 9e-10
Identities = 63/263 (23%), Positives = 103/263 (39%), Gaps = 23/263 (8%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + GS + C G +L G + C+ +G + I
Sbjct: 554 CKTPPDPVNGMVHVITDIQV-GSRINYSCTTGHRLIGHSSAECI--LSGNAAHWSTKPPI 610
Query: 117 CVQEDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFKIRYP-DLHNMVSL---CRDD 168
C + C +P + + + + +G + C+ G R +L S+ DD
Sbjct: 611 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 670
Query: 169 --GTWNN-LPIC---QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYL 222
G W+ P C C P + + +S+ ++ F + V+ +RC PGF + G +
Sbjct: 671 QVGIWSGPAPQCIIPNKCTPPNVENG--ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 728
Query: 223 ECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTS 282
+C W P C VC PP V H + R + ++ G V + C+PGY L
Sbjct: 729 KCQALNKWEPELPSCS--RVCQPPPDVLHAERT--QRDKDNFSPGQEVFYSCEPGYDLRG 784
Query: 283 DYKYITCQYGEWFPSYQVYCIKS 305
G+W P+ +KS
Sbjct: 785 AASMRCTPQGDWSPAAPTCEVKS 807
Score = 62.4 bits (150), Expect = 9e-10
Identities = 63/263 (23%), Positives = 103/263 (39%), Gaps = 23/263 (8%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + GS + C G +L G + C+ +G + I
Sbjct: 1004 CKTPPDPVNGMVHVITDIQV-GSRINYSCTTGHRLIGHSSAECI--LSGNAAHWSTKPPI 1060
Query: 117 CVQEDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFKIRYP-DLHNMVSL---CRDD 168
C + C +P + + + + +G + C+ G R +L S+ DD
Sbjct: 1061 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 1120
Query: 169 --GTWNN-LPIC---QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYL 222
G W+ P C C P + + +S+ ++ F + V+ +RC PGF + G +
Sbjct: 1121 QVGIWSGPAPQCIIPNKCTPPNVENG--ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 1178
Query: 223 ECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTS 282
+C W P C VC PP V H + R + ++ G V + C+PGY L
Sbjct: 1179 KCQALNKWEPELPSCS--RVCQPPPDVLHAERT--QRDKDNFSPGQEVFYSCEPGYDLRG 1234
Query: 283 DYKYITCQYGEWFPSYQVYCIKS 305
G+W P+ +KS
Sbjct: 1235 AASMRCTPQGDWSPAAPTCEVKS 1257
Score = 58.5 bits (140), Expect = 1e-08
Identities = 56/231 (24%), Positives = 81/231 (35%), Gaps = 18/231 (7%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 1520 PTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPA 1579
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 1580 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 1635
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + Q +F G + Y C PG+ L G+A L C
Sbjct: 1636 WEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD 1695
Query: 230 WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
WS PRC + HG V P + G V F CD G+ L
Sbjct: 1696 WSPEAPRCAVKSCDDFLGQLPHGR-VLFPLNLQL---GAKVSFVCDEGFRL 1742
Score = 58.5 bits (140), Expect = 1e-08
Identities = 60/236 (25%), Positives = 86/236 (36%), Gaps = 21/236 (8%)
Query: 57 CADPGIPENG-FRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGW 109
C P NG F + + F G+V + C G F+L G C + W
Sbjct: 1969 CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 2028
Query: 110 IPSDNSICVQEDCRIPQIEDA---EIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
C P++E+A + + E + C GF + + + C+
Sbjct: 2029 SSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVM----VGSHTVQCQ 2084
Query: 167 DDGTWN-NLPICQG-CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
+G W LP C C P +G +S Q +F G + Y C P + L G+A L C
Sbjct: 2085 TNGRWGPKLPHCSRVCQPPPEILHGEHTLSH-QDNFSPGQEVFYSCEPSYDLRGAASLHC 2143
Query: 225 LQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
WS PRC + HG V P + G V F CD G+ L
Sbjct: 2144 TPQGDWSPEAPRCTVKSCDDFLGQLPHGR-VLLPLNLQL---GAKVSFVCDEGFRL 2195
Score = 58.2 bits (139), Expect = 2e-08
Identities = 54/219 (24%), Positives = 86/219 (39%), Gaps = 22/219 (10%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQ--EDCRIPQIEDAEI 132
F G + C+ G+ L+GA C + W P+ + V+ +D + +
Sbjct: 316 FSPGQEVFYSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVKSCDDFMGQLLNGRVL 371
Query: 133 HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQG--CLRPLASSNG 189
+ G K+ C EGF+++ V L + WN+ +P+C+ C P NG
Sbjct: 372 FPVNLQLGAKVDFVCDEGFQLKGSSASYCV-LAGMESLWNSSVPVCEQIFCPSPPVIPNG 430
Query: 190 YVNISELQTSFPVGTVISYRCFP------GFKLDGSAYLECLQ----NLIWSSSPPRCLA 239
L+ FP G ++Y C P F L G + + C N +WSS PRC
Sbjct: 431 RHTGKPLEV-FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI 489
Query: 240 LEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGY 278
L C P + + GT +++ C P Y
Sbjct: 490 LGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEY 527
Score = 58.2 bits (139), Expect = 2e-08
Identities = 54/219 (24%), Positives = 86/219 (39%), Gaps = 22/219 (10%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQ--EDCRIPQIEDAEI 132
F G + C+ G+ L+GA C + W P+ + V+ +D + +
Sbjct: 766 FSPGQEVFYSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVKSCDDFMGQLLNGRVL 821
Query: 133 HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQG--CLRPLASSNG 189
+ G K+ C EGF+++ V L + WN+ +P+C+ C P NG
Sbjct: 822 FPVNLQLGAKVDFVCDEGFQLKGSSASYCV-LAGMESLWNSSVPVCEQIFCPSPPVIPNG 880
Query: 190 YVNISELQTSFPVGTVISYRCFP------GFKLDGSAYLECLQ----NLIWSSSPPRCLA 239
L+ FP G ++Y C P F L G + + C N +WSS PRC
Sbjct: 881 RHTGKPLEV-FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI 939
Query: 240 LEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGY 278
L C P + + GT +++ C P Y
Sbjct: 940 LGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEY 977
Score = 58.2 bits (139), Expect = 2e-08
Identities = 54/219 (24%), Positives = 86/219 (39%), Gaps = 22/219 (10%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQ--EDCRIPQIEDAEI 132
F G + C+ G+ L+GA C + W P+ + V+ +D + +
Sbjct: 1216 FSPGQEVFYSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVKSCDDFMGQLLNGRVL 1271
Query: 133 HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQG--CLRPLASSNG 189
+ G K+ C EGF+++ V L + WN+ +P+C+ C P NG
Sbjct: 1272 FPVNLQLGAKVDFVCDEGFQLKGSSASYCV-LAGMESLWNSSVPVCEQIFCPSPPVIPNG 1330
Query: 190 YVNISELQTSFPVGTVISYRCFP------GFKLDGSAYLECLQ----NLIWSSSPPRCLA 239
L+ FP G ++Y C P F L G + + C N +WSS PRC
Sbjct: 1331 RHTGKPLEV-FPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI 1389
Query: 240 LEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGY 278
L C P + + GT +++ C P Y
Sbjct: 1390 LGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEY 1427
Score = 57.4 bits (137), Expect = 3e-08
Identities = 35/103 (33%), Positives = 51/103 (49%), Gaps = 9/103 (8%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL---QNLIWSSSP 234
+ C P NG V+I+ T G+ ++Y C GF+L GS CL N+ W
Sbjct: 1905 KSCGPPPEPFNGMVHIN---TDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKA 1961
Query: 235 PRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPG 277
P C + C PP +S+GDF + R +++GTVV + C G
Sbjct: 1962 PICEIIS-CEPPPTISNGDFYSNNR--TSFHNGTVVTYQCHTG 2001
Score = 56.6 bits (135), Expect = 5e-08
Identities = 66/239 (27%), Positives = 102/239 (42%), Gaps = 42/239 (17%)
Query: 70 PSGGVFFE-----GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQED--C 122
P G V F G+ F C +GF+LKG++ C+ +L W +NS+ V E C
Sbjct: 1716 PHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSL-W---NNSVPVCEHIFC 1771
Query: 123 RIPQIEDAEIHNKT----YRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWN 172
P H T +G+++ TC H + + + C D G W+
Sbjct: 1772 PNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWS 1831
Query: 173 N-LPICQGCLR----------PLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
+ P C+ +R P AS +N E FPVGT ++Y C PG+
Sbjct: 1832 SPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE----FPVGTSLNYECRPGY-FGKMFS 1886
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
+ CL+NL+WSS C + C PP +G + H ++ G+ V + C+ G+ L
Sbjct: 1887 ISCLENLVWSSVEDNC-RRKSCGPPPEPFNG--MVHINTDTQF--GSTVNYSCNEGFRL 1940
Score = 55.5 bits (132), Expect = 1e-07
Identities = 65/279 (23%), Positives = 106/279 (37%), Gaps = 34/279 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKT- 136
G+ F C +GF+LKG + C+ G S +C Q C P H T
Sbjct: 2182 GAKVSFVCDEGFRLKGRSASHCV--LAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
Query: 137 ---YRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQ-----GCL 181
+G+++ C H + + + C D G W++ P C+ C
Sbjct: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACP 2299
Query: 182 RPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALE 241
P NG+ + P G ISY C PG+ L G ++ C IWS C +
Sbjct: 2300 HPPKIQNGHYIGGHVSLYLP-GMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVN 2358
Query: 242 VCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVY 301
C P ++ + + Y++G V C+ GY+L + CQ + +
Sbjct: 2359 -CSFPLFMNGISKELEMK--KVYHYGDYVTLKCEDGYTLEGS-PWSQCQADDRWDPPLAK 2414
Query: 302 CIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILA 340
C TH+ L IV + ++ +LL++ L+
Sbjct: 2415 CTS------RTHDAL-----IVGTLSGTIFFILLIIFLS 2442
Score = 52.8 bits (125), Expect = 7e-07
Identities = 52/231 (22%), Positives = 80/231 (34%), Gaps = 18/231 (7%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 170 PTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 229
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 230 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 285
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + +F G + Y C PG+ L G+A + C
Sbjct: 286 WEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 345
Query: 230 WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
WS + P C + +G V P G V+F CD G+ L
Sbjct: 346 WSPAAPTCEVKSCDDFMGQLLNGR-VLFP---VNLQLGAKVDFVCDEGFQL 392
Score = 52.8 bits (125), Expect = 7e-07
Identities = 52/231 (22%), Positives = 80/231 (34%), Gaps = 18/231 (7%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 620 PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 679
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 680 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 735
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + +F G + Y C PG+ L G+A + C
Sbjct: 736 WEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 795
Query: 230 WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
WS + P C + +G V P G V+F CD G+ L
Sbjct: 796 WSPAAPTCEVKSCDDFMGQLLNGR-VLFP---VNLQLGAKVDFVCDEGFQL 842
Score = 52.8 bits (125), Expect = 7e-07
Identities = 52/231 (22%), Positives = 80/231 (34%), Gaps = 18/231 (7%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 1070 PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 1129
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 1130 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 1185
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + +F G + Y C PG+ L G+A + C
Sbjct: 1186 WEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 1245
Query: 230 WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
WS + P C + +G V P G V+F CD G+ L
Sbjct: 1246 WSPAAPTCEVKSCDDFMGQLLNGR-VLFP---VNLQLGAKVDFVCDEGFQL 1292
Score = 48.5 bits (114), Expect = 1e-05
Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 24/187 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN--- 134
G+ F C +GF+LKG++ C+ G S +C Q C P + H
Sbjct: 379 GAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 436
Query: 135 -KTYRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPLAS 186
+ + G+ + TC H + + C D G W++ P C G L +
Sbjct: 437 LEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQA 495
Query: 187 SNGYVNISELQTS-----FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRCLAL 240
+ ++ ++L+T FP+GT + Y C P + G + + CL NL+WSS C
Sbjct: 496 PDHFL-FAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVC-KR 551
Query: 241 EVCPLPP 247
+ C PP
Sbjct: 552 KSCKTPP 558
Score = 48.5 bits (114), Expect = 1e-05
Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 24/187 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN--- 134
G+ F C +GF+LKG++ C+ G S +C Q C P + H
Sbjct: 829 GAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 886
Query: 135 -KTYRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPLAS 186
+ + G+ + TC H + + C D G W++ P C G L +
Sbjct: 887 LEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQA 945
Query: 187 SNGYVNISELQTS-----FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRCLAL 240
+ ++ ++L+T FP+GT + Y C P + G + + CL NL+WSS C
Sbjct: 946 PDHFL-FAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVC-KR 1001
Query: 241 EVCPLPP 247
+ C PP
Sbjct: 1002 KSCKTPP 1008
Score = 48.5 bits (114), Expect = 1e-05
Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 24/187 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN--- 134
G+ F C +GF+LKG++ C+ G S +C Q C P + H
Sbjct: 1279 GAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 1336
Query: 135 -KTYRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPLAS 186
+ + G+ + TC H + + C D G W++ P C G L +
Sbjct: 1337 LEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQA 1395
Query: 187 SNGYVNISELQTS-----FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRCLAL 240
+ ++ ++L+T FP+GT + Y C P + G + + CL NL+WSS C
Sbjct: 1396 PDHFL-FAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVC-KR 1451
Query: 241 EVCPLPP 247
+ C PP
Sbjct: 1452 KSCKTPP 1458
Score = 41.6 bits (96), Expect = 0.002
Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 8/82 (9%)
Query: 200 FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHP 258
FP+GT ++Y C PG+ G + + CL+N +W+ + RC + C PP +G + H
Sbjct: 63 FPIGTYLNYECRPGY--SGRPFSIICLKNSVWTGAKDRC-RRKSCRNPPDPVNG--MVH- 116
Query: 259 RPCERYNHGTVVEFYCDPGYSL 280
+ G+ +++ C GY L
Sbjct: 117 -VIKGIQFGSQIKYSCTKGYRL 137
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 75.5 bits (184), Expect = 1e-13
Identities = 67/268 (25%), Positives = 105/268 (39%), Gaps = 33/268 (12%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + F GS + C +GF+L G+ CL N + W I
Sbjct: 1457 CGPPPEPFNGMVHINTDTQF-GSTVNYSCNEGFRLIGSPSTTCLVSGN-NVTW-DKKAPI 1513
Query: 117 CVQEDCR-IPQIEDAEIHNK---TYRHGEKLIITCHEGFKIRYPDLHNMVSL-------- 164
C C P I + + ++ ++ +G + CH G PD + L
Sbjct: 1514 CEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTG-----PDGEQLFELVGERSIYC 1568
Query: 165 -CRDD--GTWNNLP----ICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLD 217
+DD G W++ P C P + + ++ F + +I +RC PGF +
Sbjct: 1569 TSKDDQVGVWSSPPPRCISTNKCTAP--EVENAIRVPGNRSFFTLTEIIRFRCQPGFVMV 1626
Query: 218 GSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPG 277
GS ++C N W P C VC PP + HG+ + + ++ G V + C+P
Sbjct: 1627 GSHTVQCQTNGRWGPKLPHC--SRVCQPPPEILHGEHTLSHQ--DNFSPGQEVFYSCEPS 1682
Query: 278 YSLTSDYKYITCQYGEWFPSYQVYCIKS 305
Y L G+W P +KS
Sbjct: 1683 YDLRGAASLHCTPQGDWSPEAPRCTVKS 1710
Score = 73.6 bits (179), Expect = 4e-13
Identities = 70/282 (24%), Positives = 118/282 (41%), Gaps = 25/282 (8%)
Query: 40 LCFGPAQLTGGFDDLQ--VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKR 97
+C + TG D + C +P P NG G+ F GS ++ C G++L G++
Sbjct: 85 ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQF-GSQIKYSCTKGYRLIGSSSA 143
Query: 98 LCLKHFNGTLGWIPSDNSICVQEDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFKI 153
C+ T+ W ++ IC + C +P + + + + +G + C+ G
Sbjct: 144 TCIIS-GDTVIW-DNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGG 201
Query: 154 RYP-DLHNMVSL---CRDD--GTWNN-LPIC---QGCLRPLASSNGYVNISELQTSFPVG 203
R +L S+ DD G W+ P C C P + + +S+ ++ F +
Sbjct: 202 RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENG--ILVSDNRSLFSLN 259
Query: 204 TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCER 263
V+ +RC PGF + G ++C W P C VC PP V H + R +
Sbjct: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS--RVCQPPPDVLHAERT--QRDKDN 315
Query: 264 YNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKS 305
++ G V + C+PGY L G+W P+ +KS
Sbjct: 316 FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKS 357
Score = 70.9 bits (172), Expect = 3e-12
Identities = 58/230 (25%), Positives = 99/230 (43%), Gaps = 25/230 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 238 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 296
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q + E + + G+++ +C G+ DL S+ C G W+
Sbjct: 297 C-QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-----DLRGAASMRCTPQGDWSPAA 350
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFPV----GTVISYRCFPGFKLDGSAYLECL---Q 226
P C+ + S + ++ + + FPV G + + C GF+L GS+ C+
Sbjct: 351 PTCE-----VKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
Query: 227 NLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDP 276
+W+SS P C + CP PP++ +G +P E + G V + CDP
Sbjct: 406 ESLWNSSVPVCEQI-FCPSPPVIPNGRHT--GKPLEVFPFGKTVNYTCDP 452
Score = 70.9 bits (172), Expect = 3e-12
Identities = 58/230 (25%), Positives = 99/230 (43%), Gaps = 25/230 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 746
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q + E + + G+++ +C G+ DL S+ C G W+
Sbjct: 747 C-QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-----DLRGAASMRCTPQGDWSPAA 800
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFPV----GTVISYRCFPGFKLDGSAYLECL---Q 226
P C+ + S + ++ + + FPV G + + C GF+L GS+ C+
Sbjct: 801 PTCE-----VKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
Query: 227 NLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDP 276
+W+SS P C + CP PP++ +G +P E + G V + CDP
Sbjct: 856 ESLWNSSVPVCEQI-FCPSPPVIPNGRHT--GKPLEVFPFGKAVNYTCDP 902
Score = 67.8 bits (164), Expect = 2e-11
Identities = 58/230 (25%), Positives = 96/230 (41%), Gaps = 25/230 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 1196
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q I E H + G+++ +C G+ DL SL C G W+
Sbjct: 1197 C-QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGY-----DLRGAASLHCTPQGDWSPEA 1250
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFP----VGTVISYRCFPGFKLDGSAYLECL---Q 226
P C + S + ++ + + FP +G +S+ C GF+L GS+ C+
Sbjct: 1251 PRC-----AVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1305
Query: 227 NLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDP 276
+W++S P C + CP PP + +G P +G + + CDP
Sbjct: 1306 RSLWNNSVPVCEHI-FCPNPPAILNGRHT--GTPSGDIPYGKEISYTCDP 1352
Score = 67.0 bits (162), Expect = 4e-11
Identities = 65/263 (24%), Positives = 105/263 (39%), Gaps = 23/263 (8%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + GS + C G +L G + C+ N T W + I
Sbjct: 1004 CKTPPDPVNGMVHVITDIQV-GSRINYSCTTGHRLIGHSSAECILSGN-TAHW-STKPPI 1060
Query: 117 CVQEDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFKIRYP-DLHNMVSL---CRDD 168
C + C +P + + + + +G + C+ G + R +L S+ DD
Sbjct: 1061 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDD 1120
Query: 169 --GTWNN-LPIC---QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYL 222
G W+ P C C P + + +S+ ++ F + V+ +RC PGF + G +
Sbjct: 1121 QVGIWSGPAPQCIIPNKCTPPNVENG--ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 1178
Query: 223 ECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTS 282
+C W P C VC PP + HG+ P + ++ G V + C+PGY L
Sbjct: 1179 KCQALNKWEPELPSCS--RVCQPPPEILHGEHT--PSHQDNFSPGQEVFYSCEPGYDLRG 1234
Query: 283 DYKYITCQYGEWFPSYQVYCIKS 305
G+W P +KS
Sbjct: 1235 AASLHCTPQGDWSPEAPRCAVKS 1257
Score = 62.4 bits (150), Expect = 9e-10
Identities = 63/263 (23%), Positives = 103/263 (39%), Gaps = 23/263 (8%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + GS + C G +L G + C+ +G + I
Sbjct: 554 CKTPPDPVNGMVHVITDIQV-GSRINYSCTTGHRLIGHSSAECI--LSGNAAHWSTKPPI 610
Query: 117 CVQEDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFKIRYP-DLHNMVSL---CRDD 168
C + C +P + + + + +G + C+ G R +L S+ DD
Sbjct: 611 CQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDD 670
Query: 169 --GTWNN-LPIC---QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYL 222
G W+ P C C P + + +S+ ++ F + V+ +RC PGF + G +
Sbjct: 671 QVGIWSGPAPQCIIPNKCTPPNVENG--ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRV 728
Query: 223 ECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTS 282
+C W P C VC PP V H + R + ++ G V + C+PGY L
Sbjct: 729 KCQALNKWEPELPSCS--RVCQPPPDVLHAERT--QRDKDNFSPGQEVFYSCEPGYDLRG 784
Query: 283 DYKYITCQYGEWFPSYQVYCIKS 305
G+W P+ +KS
Sbjct: 785 AASMRCTPQGDWSPAAPTCEVKS 807
Score = 58.5 bits (140), Expect = 1e-08
Identities = 56/231 (24%), Positives = 81/231 (35%), Gaps = 18/231 (7%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 1070 PTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPA 1129
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 1130 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 1185
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + Q +F G + Y C PG+ L G+A L C
Sbjct: 1186 WEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD 1245
Query: 230 WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
WS PRC + HG V P + G V F CD G+ L
Sbjct: 1246 WSPEAPRCAVKSCDDFLGQLPHGR-VLFPLNLQL---GAKVSFVCDEGFRL 1292
Score = 58.5 bits (140), Expect = 1e-08
Identities = 60/236 (25%), Positives = 86/236 (36%), Gaps = 21/236 (8%)
Query: 57 CADPGIPENG-FRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGW 109
C P NG F + + F G+V + C G F+L G C + W
Sbjct: 1519 CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 1578
Query: 110 IPSDNSICVQEDCRIPQIEDA---EIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
C P++E+A + + E + C GF + + + C+
Sbjct: 1579 SSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVM----VGSHTVQCQ 1634
Query: 167 DDGTWN-NLPICQG-CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
+G W LP C C P +G +S Q +F G + Y C P + L G+A L C
Sbjct: 1635 TNGRWGPKLPHCSRVCQPPPEILHGEHTLSH-QDNFSPGQEVFYSCEPSYDLRGAASLHC 1693
Query: 225 LQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
WS PRC + HG V P + G V F CD G+ L
Sbjct: 1694 TPQGDWSPEAPRCTVKSCDDFLGQLPHGR-VLLPLNLQL---GAKVSFVCDEGFRL 1745
Score = 58.2 bits (139), Expect = 2e-08
Identities = 54/219 (24%), Positives = 86/219 (39%), Gaps = 22/219 (10%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQ--EDCRIPQIEDAEI 132
F G + C+ G+ L+GA C + W P+ + V+ +D + +
Sbjct: 316 FSPGQEVFYSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVKSCDDFMGQLLNGRVL 371
Query: 133 HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQG--CLRPLASSNG 189
+ G K+ C EGF+++ V L + WN+ +P+C+ C P NG
Sbjct: 372 FPVNLQLGAKVDFVCDEGFQLKGSSASYCV-LAGMESLWNSSVPVCEQIFCPSPPVIPNG 430
Query: 190 YVNISELQTSFPVGTVISYRCFP------GFKLDGSAYLECLQ----NLIWSSSPPRCLA 239
L+ FP G ++Y C P F L G + + C N +WSS PRC
Sbjct: 431 RHTGKPLEV-FPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI 489
Query: 240 LEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGY 278
L C P + + GT +++ C P Y
Sbjct: 490 LGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEY 527
Score = 58.2 bits (139), Expect = 2e-08
Identities = 54/219 (24%), Positives = 86/219 (39%), Gaps = 22/219 (10%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQ--EDCRIPQIEDAEI 132
F G + C+ G+ L+GA C + W P+ + V+ +D + +
Sbjct: 766 FSPGQEVFYSCEPGYDLRGAASMRCTPQGD----WSPAAPTCEVKSCDDFMGQLLNGRVL 821
Query: 133 HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQG--CLRPLASSNG 189
+ G K+ C EGF+++ V L + WN+ +P+C+ C P NG
Sbjct: 822 FPVNLQLGAKVDFVCDEGFQLKGSSASYCV-LAGMESLWNSSVPVCEQIFCPSPPVIPNG 880
Query: 190 YVNISELQTSFPVGTVISYRCFP------GFKLDGSAYLECLQ----NLIWSSSPPRCLA 239
L+ FP G ++Y C P F L G + + C N +WSS PRC
Sbjct: 881 RHTGKPLEV-FPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGI 939
Query: 240 LEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGY 278
L C P + + GT +++ C P Y
Sbjct: 940 LGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEY 977
Score = 57.4 bits (137), Expect = 3e-08
Identities = 35/103 (33%), Positives = 51/103 (49%), Gaps = 9/103 (8%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL---QNLIWSSSP 234
+ C P NG V+I+ T G+ ++Y C GF+L GS CL N+ W
Sbjct: 1455 KSCGPPPEPFNGMVHIN---TDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKA 1511
Query: 235 PRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPG 277
P C + C PP +S+GDF + R +++GTVV + C G
Sbjct: 1512 PICEIIS-CEPPPTISNGDFYSNNR--TSFHNGTVVTYQCHTG 1551
Score = 56.6 bits (135), Expect = 5e-08
Identities = 66/239 (27%), Positives = 102/239 (42%), Gaps = 42/239 (17%)
Query: 70 PSGGVFFE-----GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQED--C 122
P G V F G+ F C +GF+LKG++ C+ +L W +NS+ V E C
Sbjct: 1266 PHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSL-W---NNSVPVCEHIFC 1321
Query: 123 RIPQIEDAEIHNKT----YRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWN 172
P H T +G+++ TC H + + + C D G W+
Sbjct: 1322 PNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWS 1381
Query: 173 N-LPICQGCLR----------PLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
+ P C+ +R P AS +N E FPVGT ++Y C PG+
Sbjct: 1382 SPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE----FPVGTSLNYECRPGY-FGKMFS 1436
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
+ CL+NL+WSS C + C PP +G + H ++ G+ V + C+ G+ L
Sbjct: 1437 ISCLENLVWSSVEDNC-RRKSCGPPPEPFNG--MVHINTDTQF--GSTVNYSCNEGFRL 1490
Score = 55.5 bits (132), Expect = 1e-07
Identities = 65/279 (23%), Positives = 106/279 (37%), Gaps = 34/279 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKT- 136
G+ F C +GF+LKG + C+ G S +C Q C P H T
Sbjct: 1732 GAKVSFVCDEGFRLKGRSASHCV--LAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 1789
Query: 137 ---YRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQ-----GCL 181
+G+++ C H + + + C D G W++ P C+ C
Sbjct: 1790 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACP 1849
Query: 182 RPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALE 241
P NG+ + P G ISY C PG+ L G ++ C IWS C +
Sbjct: 1850 HPPKIQNGHYIGGHVSLYLP-GMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVN 1908
Query: 242 VCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVY 301
C P ++ + + Y++G V C+ GY+L + CQ + +
Sbjct: 1909 -CSFPLFMNGISKELEMK--KVYHYGDYVTLKCEDGYTLEGS-PWSQCQADDRWDPPLAK 1964
Query: 302 CIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILA 340
C TH+ L IV + ++ +LL++ L+
Sbjct: 1965 CTS------RTHDAL-----IVGTLSGTIFFILLIIFLS 1992
Score = 52.8 bits (125), Expect = 7e-07
Identities = 52/231 (22%), Positives = 80/231 (34%), Gaps = 18/231 (7%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 170 PTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 229
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 230 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 285
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + +F G + Y C PG+ L G+A + C
Sbjct: 286 WEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 345
Query: 230 WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
WS + P C + +G V P G V+F CD G+ L
Sbjct: 346 WSPAAPTCEVKSCDDFMGQLLNGR-VLFP---VNLQLGAKVDFVCDEGFQL 392
Score = 52.8 bits (125), Expect = 7e-07
Identities = 52/231 (22%), Positives = 80/231 (34%), Gaps = 18/231 (7%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 620 PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 679
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 680 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 735
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + +F G + Y C PG+ L G+A + C
Sbjct: 736 WEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 795
Query: 230 WSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
WS + P C + +G V P G V+F CD G+ L
Sbjct: 796 WSPAAPTCEVKSCDDFMGQLLNGR-VLFP---VNLQLGAKVDFVCDEGFQL 842
Score = 48.5 bits (114), Expect = 1e-05
Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 24/187 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN--- 134
G+ F C +GF+LKG++ C+ G S +C Q C P + H
Sbjct: 379 GAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 436
Query: 135 -KTYRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPLAS 186
+ + G+ + TC H + + C D G W++ P C G L +
Sbjct: 437 LEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQA 495
Query: 187 SNGYVNISELQTS-----FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRCLAL 240
+ ++ ++L+T FP+GT + Y C P + G + + CL NL+WSS C
Sbjct: 496 PDHFL-FAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVC-KR 551
Query: 241 EVCPLPP 247
+ C PP
Sbjct: 552 KSCKTPP 558
Score = 48.5 bits (114), Expect = 1e-05
Identities = 49/187 (26%), Positives = 79/187 (42%), Gaps = 24/187 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN--- 134
G+ F C +GF+LKG++ C+ G S +C Q C P + H
Sbjct: 829 GAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 886
Query: 135 -KTYRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPLAS 186
+ + G+ + TC H + + C D G W++ P C G L +
Sbjct: 887 LEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQA 945
Query: 187 SNGYVNISELQTS-----FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRCLAL 240
+ ++ ++L+T FP+GT + Y C P + G + + CL NL+WSS C
Sbjct: 946 PDHFL-FAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVC-KR 1001
Query: 241 EVCPLPP 247
+ C PP
Sbjct: 1002 KSCKTPP 1008
Score = 41.6 bits (96), Expect = 0.002
Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 8/82 (9%)
Query: 200 FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHP 258
FP+GT ++Y C PG+ G + + CL+N +W+ + RC + C PP +G + H
Sbjct: 63 FPIGTYLNYECRPGY--SGRPFSIICLKNSVWTGAKDRC-RRKSCRNPPDPVNG--MVH- 116
Query: 259 RPCERYNHGTVVEFYCDPGYSL 280
+ G+ +++ C GY L
Sbjct: 117 -VIKGIQFGSQIKYSCTKGYRL 137
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 74.7 bits (182), Expect = 2e-13
Identities = 67/250 (26%), Positives = 108/250 (43%), Gaps = 29/250 (11%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
+Q+C P N + + +G CQ+ + ++ + C +G IP
Sbjct: 808 IQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK---DGRWQSIP-- 862
Query: 114 NSICVQE-DC-RIPQIEDAEIHN-----KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
+CV++ C + PQIE I++ ++Y HG KL TC GF+I +
Sbjct: 863 --LCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM--- 917
Query: 167 DDGTWNNLPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
G W++ P C+G C P S+G V + + S+ G ++Y+CF GF +DG A +C
Sbjct: 918 --GKWSSPPQCEGLPCKSPPEISHGVV--AHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC 973
Query: 225 LQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDY 284
L W S PP C+ + LP S + + + Y G V + C Y +
Sbjct: 974 LGEK-W-SHPPSCIKTDCLSLP---SFENAIPMGEKKDVYKAGEQVTYTCATYYKM-DGA 1027
Query: 285 KYITCQYGEW 294
+TC W
Sbjct: 1028 SNVTCINSRW 1037
Score = 73.9 bits (180), Expect = 3e-13
Identities = 63/245 (25%), Positives = 103/245 (42%), Gaps = 25/245 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P +G + G + C +GF + G CL W S
Sbjct: 931 CKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-----KW--SHPPS 983
Query: 117 CVQEDC-RIPQIEDAEIHNK---TYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN 172
C++ DC +P E+A + Y+ GE++ TC +K+ N+ + + W
Sbjct: 984 CIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKM--DGASNVTCI---NSRWT 1038
Query: 173 NLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW 230
P C+ C+ P N Y+ +S + +P G + Y+C +++ G + CL N W
Sbjct: 1039 GRPTCRDTSCVNPPTVQNAYI-VSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNW 1096
Query: 231 SSSPPRCL-ALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITC 289
+ PP+C + C PP + +GD P Y + VE+ C Y L + K ITC
Sbjct: 1097 -TEPPQCKDSTGKCGPPPPIDNGDITSF--PLSVYAPASSVEYQCQNLYQLEGN-KRITC 1152
Query: 290 QYGEW 294
+ G+W
Sbjct: 1153 RNGQW 1157
Score = 72.4 bits (176), Expect = 9e-13
Identities = 65/258 (25%), Positives = 111/258 (43%), Gaps = 15/258 (5%)
Query: 54 LQVCADPGIP-ENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPS 112
++ C+ I ENGF + S + A++ C+ G+ + G GW S
Sbjct: 445 VKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITC--GKDGW--S 500
Query: 113 DNSICVQEDCRIPQIEDAEIHNKT--YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
C++ C IP +A N ++ + L CH+G++ + +C +G
Sbjct: 501 AQPTCIKS-CDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSI-VCGYNG- 557
Query: 171 WNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW 230
W++LPIC L + ++ + + VG V+ + C PGF + G ++C +
Sbjct: 558 WSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLS 617
Query: 231 SSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
P ++ C PP + +G+ + E Y H VVE+YC+P + + K I C
Sbjct: 618 PDLPICKEQVQSCGPPPELLNGNV--KEKTKEEYGHSEVVEYYCNPRFLMKGPNK-IQCV 674
Query: 291 YGEWFPSYQVYCIKSEQT 308
GEW + CI E T
Sbjct: 675 DGEW--TTLPVCIVEEST 690
Score = 64.3 bits (155), Expect = 2e-10
Identities = 55/236 (23%), Positives = 96/236 (40%), Gaps = 37/236 (15%)
Query: 77 EGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN-SICVQEDCRIPQIEDAEIHNK 135
EG+ A + C+ G++ G +C K W+ + C + C P
Sbjct: 44 EGTQAIYKCRPGYRSLGNVIMVCRKG-----EWVALNPLRKCQKRPCGHPGDTPFGTFTL 98
Query: 136 T----YRHGEKLIITCHEGFK----IRYPDLHNMVSLCRDDGTWNNLPICQ--GCLRPLA 185
T + +G K + TC+EG++ I Y + C DG N++PIC+ CL A
Sbjct: 99 TGGNVFEYGVKAVYTCNEGYQLLGEINYRE-------CDTDGWTNDIPICEVVKCLPVTA 151
Query: 186 SSNGYVNISELQTS--FPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVC 243
NG + S ++ + G + + C G+K++G + C + WS P+C+ + C
Sbjct: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEIS-C 210
Query: 244 PLPPMVSHGDFVCHPRPCER---YNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFP 296
P +++ P + Y ++ C+ GY S+ C W P
Sbjct: 211 KSPDVINGS-------PISQKIIYKENERFQYKCNMGYEY-SERGDAVCTESGWRP 258
Score = 60.1 bits (144), Expect = 4e-09
Identities = 61/258 (23%), Positives = 101/258 (39%), Gaps = 29/258 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + NG ++ E ++ C G++ +C + GW P +
Sbjct: 210 CKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTES-----GWRPLPS-- 261
Query: 117 CVQEDCRIPQIEDAEIHNKTYRH--GEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
C ++ C P I + + +H G+++ C GF YP + C G W
Sbjct: 262 CEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGF---YPATRGNTAKCTSTG-WIPA 317
Query: 175 PIC--QGCLRPLASSNGYVNISELQTSFPV--GTVISYRCFPGFKLDGSAY---LECLQN 227
P C + C P G + + + FPV G SY C F+ +Y + C Q+
Sbjct: 318 PRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQD 377
Query: 228 LIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYI 287
WS + P L C P + +G H R ++ G ++ C PGY+L +
Sbjct: 378 G-WSPAVP---CLRKCYFP-YLENGYNQNHGR---KFVQGKSIDVACHPGYALPKAQTTV 429
Query: 288 TCQYGEWFPSYQVYCIKS 305
TC W P+ + +K+
Sbjct: 430 TCMENGWSPTPRCIRVKT 447
Score = 56.2 bits (134), Expect = 6e-08
Identities = 56/244 (22%), Positives = 94/244 (38%), Gaps = 20/244 (8%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C D E+G+ S ++ G F+C + F + G C+ +G +P +I
Sbjct: 691 CGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI---HGVWTQLPQCVAI 747
Query: 117 CVQEDCRIPQIEDAEIH---NKTYRHGEKLIITCH--EGFKIRYPDLHNMVSLCRDDGTW 171
+ C+ + E H K + H + C EG+ +H + R D
Sbjct: 748 DKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGW------IHTVCINGRWDPEV 801
Query: 172 N-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW 230
N ++ Q C P N + + L ++ G +S C + + + C W
Sbjct: 802 NCSMAQIQLCPPPPQIPNSHNMTTTL--NYRDGEKVSVLCQENYLIQEGEEITCKDGR-W 858
Query: 231 SSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
S P C+ C PP + HG E Y HGT + + C+ G+ + S+ TC
Sbjct: 859 QSIP-LCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRI-SEENETTCY 916
Query: 291 YGEW 294
G+W
Sbjct: 917 MGKW 920
Score = 39.7 bits (91), Expect = 0.006
Identities = 23/96 (23%), Positives = 38/96 (39%), Gaps = 2/96 (2%)
Query: 199 SFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHP 258
++P GT Y+C PG++ G+ + C + + +P R C P G F
Sbjct: 41 TYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTL-- 98
Query: 259 RPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
+ +G + C+ GY L + Y C W
Sbjct: 99 TGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGW 134
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 73.6 bits (179), Expect = 4e-13
Identities = 64/259 (24%), Positives = 114/259 (44%), Gaps = 31/259 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +P P NG + F + ++ C G++L G++ C+ N T+ W + +
Sbjct: 96 CRNPPDPVNGMAHVIKDIQFRSQI-KYSCPKGYRLIGSSSATCIISGN-TVIW-DNKTPV 152
Query: 117 CVQEDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFK-------IRYPDLHNMVSLC 165
C + C +P + I + + +G + C+ G + + P ++
Sbjct: 153 CDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIY---CTS 209
Query: 166 RDD--GTWNN-LPIC---QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGS 219
+DD G W+ P C C P + + +S+ ++ F + V+ +RC PGF + G
Sbjct: 210 KDDQVGIWSGPAPQCIIPNKCTPPNVENG--ILVSDNRSLFSLNEVVEFRCQPGFGMKGP 267
Query: 220 AYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYS 279
++++C W P C VC PP V H + R + ++ G V + C+PGY
Sbjct: 268 SHVKCQALNKWEPELPSC--SRVCQPPPDVLHAERT--QRDKDNFSPGQEVFYSCEPGYD 323
Query: 280 LT-SDYKYITCQYGEWFPS 297
L S Y + T Q G+W P+
Sbjct: 324 LRGSTYLHCTPQ-GDWSPA 341
Score = 67.4 bits (163), Expect = 3e-11
Identities = 57/210 (27%), Positives = 91/210 (43%), Gaps = 19/210 (9%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE-DCRIPQIEDAEI- 132
F G + C+ G+ L+G+T C + W P+ V+ D + Q+ + +
Sbjct: 308 FSPGQEVFYSCEPGYDLRGSTYLHCTPQGD----WSPAAPRCEVKSCDDFLGQLPNGHVL 363
Query: 133 HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQ--GCLRPLASSNG 189
+ G K+ C EGF+++ V L + WN+ +P+C+ C P NG
Sbjct: 364 FPLNLQLGAKVDFVCDEGFQLKGSSASYCV-LAGMESLWNSSVPVCERKSCETPPVPVNG 422
Query: 190 YVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL---QNLIWSSSPPRCLALEVCPLP 246
V++ T VG+ I+Y C G +L G + EC+ WS PP C + CP P
Sbjct: 423 MVHVI---TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQI-FCPNP 478
Query: 247 PMVSHGDFVCHPRPCERYNHGTVVEFYCDP 276
P + +G P +G V + CDP
Sbjct: 479 PAILNGRHT--GTPLGDIPYGKEVSYTCDP 506
Score = 65.5 bits (158), Expect = 1e-10
Identities = 68/272 (25%), Positives = 98/272 (36%), Gaps = 22/272 (8%)
Query: 53 DLQVCADPGIPENG-FRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNG 105
D +C P NG F + S F GSV +HC G F+L G C +
Sbjct: 154 DRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQ 213
Query: 106 TLGWIPSDNSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMV 162
W + C P +E+ + + + E + C GF ++ P
Sbjct: 214 VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVK-- 271
Query: 163 SLCRDDGTWN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
C+ W LP C +P + +F G + Y C PG+ L GS Y
Sbjct: 272 --CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTY 329
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL- 280
L C WS + PRC + +G V P + G V+F CD G+ L
Sbjct: 330 LHCTPQGDWSPAAPRCEVKSCDDFLGQLPNG-HVLFPLNLQL---GAKVDFVCDEGFQLK 385
Query: 281 --TSDYKYITCQYGEWFPSYQVYCIKSEQTWP 310
++ Y + W S V KS +T P
Sbjct: 386 GSSASYCVLAGMESLWNSSVPVCERKSCETPP 417
Score = 52.4 bits (124), Expect = 9e-07
Identities = 30/103 (29%), Positives = 53/103 (51%), Gaps = 9/103 (8%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL---QNLIWSSSP 234
+ C P NG ++ + + I Y C G++L GS+ C+ +IW +
Sbjct: 94 KSCRNPPDPVNGMAHVIK---DIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKT 150
Query: 235 PRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPG 277
P C + +C LPP +++GDF R E +++G+VV ++C+ G
Sbjct: 151 PVCDRI-ICGLPPTIANGDFTSISR--EYFHYGSVVTYHCNLG 190
Score = 50.1 bits (118), Expect = 5e-06
Identities = 53/188 (28%), Positives = 79/188 (42%), Gaps = 24/188 (12%)
Query: 70 PSGGVFFE-----GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRI 124
P+G V F G+ F C +GF+LKG++ C+ G S +C ++ C
Sbjct: 358 PNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCERKSCET 415
Query: 125 PQIE-DAEIHNKTYRH-GEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NLPICQG-- 179
P + + +H T H G ++ +C G ++ + L + W+ PICQ
Sbjct: 416 PPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECI-LSGNTAHWSMKPPICQQIF 474
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPG------FKLDGSAYL----ECLQNLI 229
C P A NG + L P G +SY C P F L G + + E N +
Sbjct: 475 CPNPPAILNGRHTGTPLG-DIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGV 533
Query: 230 WSSSPPRC 237
WSS PRC
Sbjct: 534 WSSPAPRC 541
Score = 39.3 bits (90), Expect = 0.008
Identities = 24/82 (29%), Positives = 43/82 (52%), Gaps = 8/82 (9%)
Query: 200 FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHP 258
FP+GT ++Y C PG+ G + + CL+N +W+S+ +C + C PP +G + H
Sbjct: 55 FPIGTYLNYECRPGY--SGRPFSIICLKNSVWTSAKDKC-KRKSCRNPPDPVNG--MAH- 108
Query: 259 RPCERYNHGTVVEFYCDPGYSL 280
+ + +++ C GY L
Sbjct: 109 -VIKDIQFRSQIKYSCPKGYRL 129
>gi|187960042 selectin E precursor [Homo sapiens]
Length = 610
Score = 72.8 bits (177), Expect = 7e-13
Identities = 66/253 (26%), Positives = 96/253 (37%), Gaps = 25/253 (9%)
Query: 63 PENGFRT--PSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE 120
P NGF + G F + F C++GF+L GA C N W ++ C
Sbjct: 248 PANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN----W-DNEKPTCKAV 302
Query: 121 DCR-IPQIEDAEIHNKTYRHGEKLI-----ITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
CR + Q ++ + GE TC EGF ++ P C G W
Sbjct: 303 TCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVE----CTTQGQWTQQ 358
Query: 174 LPICQG--CLRPLASSNGYVN-ISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW 230
+P+C+ C GY+N + SF G+ + C GF L GS L+C W
Sbjct: 359 IPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEW 418
Query: 231 SSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
+ P C A+ C G C P + + + F C+ G+ L +
Sbjct: 419 DNEKPTCEAVR-CDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTS 477
Query: 291 YGEW---FPSYQV 300
G+W PS QV
Sbjct: 478 QGQWTEEVPSCQV 490
Score = 57.8 bits (138), Expect = 2e-08
Identities = 58/246 (23%), Positives = 91/246 (36%), Gaps = 29/246 (11%)
Query: 63 PENGF----RTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICV 118
P+NG +P+G F+ S F C++GF L+G + C T G +C
Sbjct: 310 PQNGSVRCSHSPAGEFTFKSS-CNFTCEEGFMLQGPAQVECT-----TQGQWTQQIPVCE 363
Query: 119 QEDCRIPQIEDAEIHN------KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN 172
C + N ++R+G +C +GF ++ + C G W+
Sbjct: 364 AFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLK----GSKRLQCGPTGEWD 419
Query: 173 N-LPICQG--CLRPLASSNGYVNISELQTS-FPVGTVISYRCFPGFKLDGSAYLECLQNL 228
N P C+ C G V + F + ++ C GF+L GS LEC
Sbjct: 420 NEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQG 479
Query: 229 IWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYIT 288
W+ P C ++ C + + C P GTV +F C G++L
Sbjct: 480 QWTEEVPSCQVVK-CSSLAVPGKINMSCSGEPV----FGTVCKFACPEGWTLNGSAARTC 534
Query: 289 CQYGEW 294
G W
Sbjct: 535 GATGHW 540
Score = 57.4 bits (137), Expect = 3e-08
Identities = 34/133 (25%), Positives = 54/133 (40%), Gaps = 4/133 (3%)
Query: 165 CRDDGTWNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
C G W+ +P C C +NG+V + SFP T ++ C GF+L G+
Sbjct: 224 CMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQS 283
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLT 281
L+C + W + P C A+ C +G C P + + F C+ G+ L
Sbjct: 284 LQCTSSGNWDNEKPTCKAV-TCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQ 342
Query: 282 SDYKYITCQYGEW 294
+ G+W
Sbjct: 343 GPAQVECTTQGQW 355
Score = 57.0 bits (136), Expect = 4e-08
Identities = 56/197 (28%), Positives = 77/197 (39%), Gaps = 28/197 (14%)
Query: 57 CADPGIPENGFRT---PSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
C PE G+ + G F GS F C+ GF LKG+ + C G G ++
Sbjct: 367 CTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQC-----GPTGEWDNE 421
Query: 114 NSICVQEDCR--------IPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL- 164
C C + + + I TY+ +C EGF +LH L
Sbjct: 422 KPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYK--SSCAFSCEEGF-----ELHGSTQLE 474
Query: 165 CRDDGTWNN-LPICQGCLRPLASSNGYVNISELQTSFPV-GTVISYRCFPGFKLDGSAYL 222
C G W +P CQ + G +N+S + PV GTV + C G+ L+GSA
Sbjct: 475 CTSQGQWTEEVPSCQVVKCSSLAVPGKINMS--CSGEPVFGTVCKFACPEGWTLNGSAAR 532
Query: 223 ECLQNLIWSSSPPRCLA 239
C WS P C A
Sbjct: 533 TCGATGHWSGLLPTCEA 549
Score = 32.3 bits (72), Expect = 1.0
Identities = 28/132 (21%), Positives = 48/132 (36%), Gaps = 4/132 (3%)
Query: 165 CRDDGTWNNLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYL 222
C+ D ++ L Q C + +G + S +F + S C G+ +
Sbjct: 163 CKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETM 222
Query: 223 ECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTS 282
+C+ + WS+ P C +E C ++G C P + T F C+ G+ L
Sbjct: 223 QCMSSGEWSAPIPACNVVE-CDAVTNPANGFVECFQNP-GSFPWNTTCTFDCEEGFELMG 280
Query: 283 DYKYITCQYGEW 294
G W
Sbjct: 281 AQSLQCTSSGNW 292
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 72.4 bits (176), Expect = 9e-13
Identities = 71/259 (27%), Positives = 96/259 (37%), Gaps = 25/259 (9%)
Query: 57 CADPGIPENGFRTPSGGV-FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWI-PSDN 114
C P + NG T F G+ + C GF L G K C G W PS
Sbjct: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
Query: 115 SICVQED----CRIPQIEDAEIHNKT---YRHGEKLIITCHEGFKIRYPDLHNMVSLCRD 167
C++ C P+++ NKT Y H + + + C+ GF + + V C
Sbjct: 779 --CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMN----GSRVIRCHT 832
Query: 168 DGTW-NNLPICQ-----GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
D TW +P C GC P + NG + F G I Y C G+ L G A
Sbjct: 833 DNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNI-ARFSPGMSILYSCDQGYLLVGEAL 891
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLT 281
L C WS P C + C P + PR + Y +G VV C+ GY L
Sbjct: 892 LLCTHEGTWSQPAPHCKEVN-CSSPADMDGIQKGLEPR--KMYQYGAVVTLECEDGYMLE 948
Query: 282 SDYKYITCQYGEWFPSYQV 300
+ +W P V
Sbjct: 949 GSPQSQCQSDHQWNPPLAV 967
Score = 63.9 bits (154), Expect = 3e-10
Identities = 57/228 (25%), Positives = 95/228 (41%), Gaps = 30/228 (13%)
Query: 85 CQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN----KTYRHG 140
CQDG++L G ++C NG W +C C P + H + + +G
Sbjct: 685 CQDGYQLTGHAYQMCQDAENGI--WFKKI-PLCKVIHCHPPPVIVNGKHTGMMAENFLYG 741
Query: 141 EKLIITCHEGFKIRYPDLHNMVSLCRDD----GTWNNLPICQGCLR--PLAS------SN 188
++ C +GF + L CR D G+W+ P Q CLR P+ +
Sbjct: 742 NEVSYECDQGFYL----LGEKKLQCRSDSKGHGSWSG-PSPQ-CLRSPPVTRCPNPEVKH 795
Query: 189 GYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCL--ALEVCPLP 246
GY +++ +++ ++ C PGF ++GS + C + W P C+ A CP P
Sbjct: 796 GY-KLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPP 854
Query: 247 PMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
P +G+ R++ G + + CD GY L + + G W
Sbjct: 855 PKTPNGNHT--GGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 900
Score = 63.5 bits (153), Expect = 4e-10
Identities = 62/243 (25%), Positives = 101/243 (41%), Gaps = 30/243 (12%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN 134
+F F C GF LKG+++ C W P + +C +E C+ + +
Sbjct: 620 YFYNDTVTFKCYSGFTLKGSSQIRC----KADNTWDP-EIPVCEKETCQ--HVRQSLQEL 672
Query: 135 KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRD--DGTW-NNLPICQ--GCLRPLASSNG 189
E + +C +G+++ + +C+D +G W +P+C+ C P NG
Sbjct: 673 PAGSRVELVNTSCQDGYQL----TGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNG 728
Query: 190 YVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL----IWSSSPPRCL---ALEV 242
+ + +F G +SY C GF L G L+C + WS P+CL +
Sbjct: 729 -KHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTR 787
Query: 243 CPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQY-GEWFPSYQVY 301
CP P V HG + + Y+H +V C+PG+ + + I C W P
Sbjct: 788 CP-NPEVKHGYKL--NKTHSAYSHNDIVYVDCNPGFIMNGS-RVIRCHTDNTWVPGVPT- 842
Query: 302 CIK 304
CIK
Sbjct: 843 CIK 845
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/201 (26%), Positives = 85/201 (42%), Gaps = 24/201 (11%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIP------QIEDAEIHNKT 136
F C GF LKG+ + C N W PS +C +++C+ P Q ED H
Sbjct: 377 FACMFGFTLKGSKQIRC----NAQGTWEPSA-PVC-EKECQAPPNILNGQKEDR--HMVR 428
Query: 137 YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISEL 196
+ G + +C+ G+ + + C +G W P C + G +++
Sbjct: 429 FDPGTSIKYSCNPGYVL----VGEESIQCTSEGVWT--PPVPQCKVAACEATGRQLLTKP 482
Query: 197 QTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVC 256
Q F V ++ C G+KL GS Y EC + W C + CP PP++ +G
Sbjct: 483 QHQF-VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEI-TCPPPPVIYNGAHT- 539
Query: 257 HPRPCERYNHGTVVEFYCDPG 277
E + +GT V + C+PG
Sbjct: 540 -GSSLEDFPYGTTVTYTCNPG 559
Score = 58.9 bits (141), Expect = 1e-08
Identities = 74/297 (24%), Positives = 116/297 (39%), Gaps = 30/297 (10%)
Query: 34 LWFQLALCFGPAQLTGGFD--DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKL 91
+W Q +GP +L L+ A P I + + G G + C+ G+ L
Sbjct: 130 VWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLL 189
Query: 92 KGATKRLCLKHFNGTLGWIPSDNSICVQEDCR-IPQIEDAEIHNKTY-RHGEKLIITCHE 149
G CL +G +P C + C+ + + + ++ R G C E
Sbjct: 190 VGEKIINCLS--SGKWSAVPPT---CEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDE 244
Query: 150 GFKIRYPDLHNMVSLCRDDGTWNNLPICQG--CLRPLASSNGYVNISELQTSFPVGTVIS 207
G++++ P V + W +P+C+ C P NG +I + G++++
Sbjct: 245 GYRLQGPPSSRCV-IAGQGVAWTKMPVCEEIFCPSPPPILNGR-HIGNSLANVSYGSIVT 302
Query: 208 YRCFP------GFKLDGSAYLECLQNL----IWSSSPPRC-LALEVCPLP-PMVSHGDFV 255
Y C P F L G + L C + WS PRC L+ P P + G V
Sbjct: 303 YTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMV 362
Query: 256 CHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ-YGEWFPSYQVYCIKSEQTWPS 311
+ +RY + V F C G++L K I C G W PS V C K Q P+
Sbjct: 363 SGQK--DRYTYNDTVIFACMFGFTLKGS-KQIRCNAQGTWEPSAPV-CEKECQAPPN 415
Score = 57.8 bits (138), Expect = 2e-08
Identities = 55/236 (23%), Positives = 91/236 (38%), Gaps = 26/236 (11%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQ--IEDAEIHNK 135
G A F C +G++L+G C+ G + W + +C + C P + I N
Sbjct: 235 GVTANFFCDEGYRLQGPPSSRCVIAGQG-VAW--TKMPVCEEIFCPSPPPILNGRHIGNS 291
Query: 136 --TYRHGEKLIITC----HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPL 184
+G + TC EG + + + C D GTW+ P C+ +
Sbjct: 292 LANVSYGSIVTYTCDPDPEEG--VNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAV 349
Query: 185 ASSNGYV----NISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
+ + +S + + + + C GF L GS + C W S P C
Sbjct: 350 QCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-- 407
Query: 241 EVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFP 296
+ C PP + +G R R++ GT +++ C+PGY L + G W P
Sbjct: 408 KECQAPPNILNGQK--EDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTP 461
Score = 57.4 bits (137), Expect = 3e-08
Identities = 59/215 (27%), Positives = 80/215 (37%), Gaps = 22/215 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSDNSICVQEDCRIPQIEDA-EIH 133
G+V R+ C F+L G LC+ W P C P + +I
Sbjct: 44 GTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIR 103
Query: 134 NKT-YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN--NLPICQG-----CLRPLA 185
T YRHG+ + C F + N C+ + W LP C C
Sbjct: 104 GSTPYRHGDSVTFACKTNFSMN----GNKSVWCQANNMWGPTRLPTCVSVFPLECPALPM 159
Query: 186 SSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPL 245
NG+ + SE S G ++Y C G+ L G + CL + WS+ PP C C
Sbjct: 160 IHNGH-HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEAR-CKS 217
Query: 246 PPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
+G V P P R G F+CD GY L
Sbjct: 218 LGRFPNGK-VKEP-PILRV--GVTANFFCDEGYRL 248
Score = 56.6 bits (135), Expect = 5e-08
Identities = 59/234 (25%), Positives = 93/234 (39%), Gaps = 43/234 (18%)
Query: 85 CQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN----KTYRHG 140
C +G+KL G+ + C GT+ W + +C + C P + H + + +G
Sbjct: 495 CGEGYKLSGSVYQEC----QGTIPWF-MEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYG 549
Query: 141 EKLIITCHEG------FKIRYPDLHNMVSLCRDDGTWNN-LPICQGCLRPLASS-----N 188
+ TC+ G F + S ++ GTW+ P+C+ L + S N
Sbjct: 550 TTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIAN 609
Query: 189 GYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPM 248
GY IS + + ++++C+ GF L GS+ + C + W P C E C
Sbjct: 610 GY-KISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVC-EKETCQ---- 663
Query: 249 VSHGDFVCHPR-PCERYNHGTVVEFY---CDPGYSLTSDYKYITCQYGE---WF 295
H R + G+ VE C GY LT + Y CQ E WF
Sbjct: 664 --------HVRQSLQELPAGSRVELVNTSCQDGYQLTG-HAYQMCQDAENGIWF 708
Score = 48.5 bits (114), Expect = 1e-05
Identities = 29/103 (28%), Positives = 45/103 (43%), Gaps = 7/103 (6%)
Query: 137 YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NLPICQG-CLRPLASSNGYVNIS 194
Y + + +I C GF ++ + C GTW + P+C+ C P NG
Sbjct: 369 YTYNDTVIFACMFGFTLK----GSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDR 424
Query: 195 ELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
+ F GT I Y C PG+ L G ++C +W+ P+C
Sbjct: 425 HM-VRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC 466
Score = 47.0 bits (110), Expect = 4e-05
Identities = 40/198 (20%), Positives = 76/198 (38%), Gaps = 18/198 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +P + + + + C GF + G+ C H + T W+P +
Sbjct: 788 CPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC--HTDNT--WVPGVPTC 843
Query: 117 CVQEDCRIPQIEDAEIHNKT------YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ P N T + G ++ +C +G+ + + + LC +GT
Sbjct: 844 IKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLL----VGEALLLCTHEGT 899
Query: 171 WNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
W+ P C+ C P A +G E + + G V++ C G+ L+GS +C +
Sbjct: 900 WSQPAPHCKEVNCSSP-ADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSD 958
Query: 228 LIWSSSPPRCLALEVCPL 245
W+ C + + P+
Sbjct: 959 HQWNPPLAVCRSRSLAPV 976
Score = 45.4 bits (106), Expect = 1e-04
Identities = 41/132 (31%), Positives = 53/132 (40%), Gaps = 15/132 (11%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ----NLIWSSSPP 235
C P NG IS T VGTVI Y C F+L G L C+ + W P
Sbjct: 23 CGSPPPILNG--RISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 236 RC---LALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYG 292
+C CP P+V G + P Y HG V F C +S+ + K + CQ
Sbjct: 81 KCEYFNKYSSCP-EPIVPGGYKIRGSTP---YRHGDSVTFACKTNFSMNGN-KSVWCQAN 135
Query: 293 E-WFPSYQVYCI 303
W P+ C+
Sbjct: 136 NMWGPTRLPTCV 147
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 72.4 bits (176), Expect = 9e-13
Identities = 58/229 (25%), Positives = 95/229 (41%), Gaps = 26/229 (11%)
Query: 85 CQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN----KTYRHG 140
C +G+KL G+ + C GT+ W + +C + C P + H + + +G
Sbjct: 495 CGEGYKLSGSVYQEC----QGTIPWF-MEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYG 549
Query: 141 EKLIITCHEG------FKIRYPDLHNMVSLCRDDGTWNN-LPICQGCLRPLASS-----N 188
+ TC+ G F + S ++ GTW+ P+C+ L + S N
Sbjct: 550 TTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIAN 609
Query: 189 GYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPM 248
GY IS + + ++++C+ GF L GS+ + C + W P C + C PP
Sbjct: 610 GY-KISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCE--KGCQSPPG 666
Query: 249 VSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPS 297
+ HG + G V++ CDPGY L + G W PS
Sbjct: 667 LHHGRHTGGNTVF--FVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPS 713
Score = 72.4 bits (176), Expect = 9e-13
Identities = 71/259 (27%), Positives = 96/259 (37%), Gaps = 25/259 (9%)
Query: 57 CADPGIPENGFRTPSGGV-FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWI-PSDN 114
C P + NG T F G+ + C GF L G K C G W PS
Sbjct: 778 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 837
Query: 115 SICVQED----CRIPQIEDAEIHNKT---YRHGEKLIITCHEGFKIRYPDLHNMVSLCRD 167
C++ C P+++ NKT Y H + + + C+ GF + + V C
Sbjct: 838 --CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMN----GSRVIRCHT 891
Query: 168 DGTW-NNLPICQ-----GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
D TW +P C GC P + NG + F G I Y C G+ L G A
Sbjct: 892 DNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNI-ARFSPGMSILYSCDQGYLLVGEAL 950
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLT 281
L C WS P C + C P + PR + Y +G VV C+ GY L
Sbjct: 951 LLCTHEGTWSQPAPHCKEVN-CSSPADMDGIQKGLEPR--KMYQYGAVVTLECEDGYMLE 1007
Query: 282 SDYKYITCQYGEWFPSYQV 300
+ +W P V
Sbjct: 1008 GSPQSQCQSDHQWNPPLAV 1026
Score = 63.9 bits (154), Expect = 3e-10
Identities = 57/228 (25%), Positives = 95/228 (41%), Gaps = 30/228 (13%)
Query: 85 CQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN----KTYRHG 140
CQDG++L G ++C NG W +C C P + H + + +G
Sbjct: 744 CQDGYQLTGHAYQMCQDAENGI--WFKKI-PLCKVIHCHPPPVIVNGKHTGMMAENFLYG 800
Query: 141 EKLIITCHEGFKIRYPDLHNMVSLCRDD----GTWNNLPICQGCLR--PLAS------SN 188
++ C +GF + L CR D G+W+ P Q CLR P+ +
Sbjct: 801 NEVSYECDQGFYL----LGEKKLQCRSDSKGHGSWSG-PSPQ-CLRSPPVTRCPNPEVKH 854
Query: 189 GYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCL--ALEVCPLP 246
GY +++ +++ ++ C PGF ++GS + C + W P C+ A CP P
Sbjct: 855 GY-KLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPP 913
Query: 247 PMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
P +G+ R++ G + + CD GY L + + G W
Sbjct: 914 PKTPNGNHT--GGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 959
Score = 58.9 bits (141), Expect = 1e-08
Identities = 74/297 (24%), Positives = 116/297 (39%), Gaps = 30/297 (10%)
Query: 34 LWFQLALCFGPAQLTGGFD--DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKL 91
+W Q +GP +L L+ A P I + + G G + C+ G+ L
Sbjct: 130 VWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLL 189
Query: 92 KGATKRLCLKHFNGTLGWIPSDNSICVQEDCR-IPQIEDAEIHNKTY-RHGEKLIITCHE 149
G CL +G +P C + C+ + + + ++ R G C E
Sbjct: 190 VGEKIINCLS--SGKWSAVPPT---CEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDE 244
Query: 150 GFKIRYPDLHNMVSLCRDDGTWNNLPICQG--CLRPLASSNGYVNISELQTSFPVGTVIS 207
G++++ P V + W +P+C+ C P NG +I + G++++
Sbjct: 245 GYRLQGPPSSRCV-IAGQGVAWTKMPVCEEIFCPSPPPILNGR-HIGNSLANVSYGSIVT 302
Query: 208 YRCFP------GFKLDGSAYLECLQNL----IWSSSPPRC-LALEVCPLP-PMVSHGDFV 255
Y C P F L G + L C + WS PRC L+ P P + G V
Sbjct: 303 YTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMV 362
Query: 256 CHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ-YGEWFPSYQVYCIKSEQTWPS 311
+ +RY + V F C G++L K I C G W PS V C K Q P+
Sbjct: 363 SGQK--DRYTYNDTVIFACMFGFTLKGS-KQIRCNAQGTWEPSAPV-CEKECQAPPN 415
Score = 57.8 bits (138), Expect = 2e-08
Identities = 55/236 (23%), Positives = 91/236 (38%), Gaps = 26/236 (11%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQ--IEDAEIHNK 135
G A F C +G++L+G C+ G + W + +C + C P + I N
Sbjct: 235 GVTANFFCDEGYRLQGPPSSRCVIAGQG-VAW--TKMPVCEEIFCPSPPPILNGRHIGNS 291
Query: 136 --TYRHGEKLIITC----HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPL 184
+G + TC EG + + + C D GTW+ P C+ +
Sbjct: 292 LANVSYGSIVTYTCDPDPEEG--VNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAV 349
Query: 185 ASSNGYV----NISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
+ + +S + + + + C GF L GS + C W S P C
Sbjct: 350 QCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-- 407
Query: 241 EVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFP 296
+ C PP + +G R R++ GT +++ C+PGY L + G W P
Sbjct: 408 KECQAPPNILNGQK--EDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTP 461
Score = 57.4 bits (137), Expect = 3e-08
Identities = 59/215 (27%), Positives = 80/215 (37%), Gaps = 22/215 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSDNSICVQEDCRIPQIEDA-EIH 133
G+V R+ C F+L G LC+ W P C P + +I
Sbjct: 44 GTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIR 103
Query: 134 NKT-YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN--NLPICQG-----CLRPLA 185
T YRHG+ + C F + N C+ + W LP C C
Sbjct: 104 GSTPYRHGDSVTFACKTNFSMN----GNKSVWCQANNMWGPTRLPTCVSVFPLECPALPM 159
Query: 186 SSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPL 245
NG+ + SE S G ++Y C G+ L G + CL + WS+ PP C C
Sbjct: 160 IHNGH-HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEAR-CKS 217
Query: 246 PPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
+G V P P R G F+CD GY L
Sbjct: 218 LGRFPNGK-VKEP-PILRV--GVTANFFCDEGYRL 248
Score = 55.8 bits (133), Expect = 8e-08
Identities = 79/314 (25%), Positives = 118/314 (37%), Gaps = 60/314 (19%)
Query: 5 MNPSNGDGFLEQQQQQQQPQSPQRLLAVILWF-QLALCFGPAQLTGGFDDLQVCADPGIP 63
+N S G+G+ Q+ Q I WF ++ LC ++T C P +
Sbjct: 491 VNSSCGEGYKLSGSVYQECQG------TIPWFMEIRLC---KEIT--------CPPPPVI 533
Query: 64 ENGFRTPSGGVFFE-GSVARFHCQDG------FKLKGATKRLCLKHFNGTLGW---IPSD 113
NG T S F G+ + C G F L G + C + W P
Sbjct: 534 YNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLC 593
Query: 114 NSICVQEDCRIPQIEDA-EIHNKT--YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C I + +I K Y + + + C+ GF ++ + C+ D T
Sbjct: 594 KLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLK----GSSQIRCKADNT 649
Query: 171 WN-NLPICQ-GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL 228
W+ +P+C+ GC P +G + F G + Y C PG+ L G+ + C+ +
Sbjct: 650 WDPEIPVCEKGCQSPPGLHHGR-HTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSG 708
Query: 229 IWSSSPPRCLALEVCPLPPMVSHGDFVCHPR-PCERYNHGTVVEFY---CDPGYSLTSDY 284
WS S PRC E C H R + G+ VE C GY LT +
Sbjct: 709 NWSPSAPRC--EETCQ------------HVRQSLQELPAGSRVELVNTSCQDGYQLTG-H 753
Query: 285 KYITCQYGE---WF 295
Y CQ E WF
Sbjct: 754 AYQMCQDAENGIWF 767
Score = 48.5 bits (114), Expect = 1e-05
Identities = 29/103 (28%), Positives = 45/103 (43%), Gaps = 7/103 (6%)
Query: 137 YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NLPICQG-CLRPLASSNGYVNIS 194
Y + + +I C GF ++ + C GTW + P+C+ C P NG
Sbjct: 369 YTYNDTVIFACMFGFTLK----GSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDR 424
Query: 195 ELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
+ F GT I Y C PG+ L G ++C +W+ P+C
Sbjct: 425 HM-VRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC 466
Score = 47.0 bits (110), Expect = 4e-05
Identities = 40/198 (20%), Positives = 76/198 (38%), Gaps = 18/198 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +P + + + + C GF + G+ C H + T W+P +
Sbjct: 847 CPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC--HTDNT--WVPGVPTC 902
Query: 117 CVQEDCRIPQIEDAEIHNKT------YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ P N T + G ++ +C +G+ + + + LC +GT
Sbjct: 903 IKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLL----VGEALLLCTHEGT 958
Query: 171 WNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
W+ P C+ C P A +G E + + G V++ C G+ L+GS +C +
Sbjct: 959 WSQPAPHCKEVNCSSP-ADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSD 1017
Query: 228 LIWSSSPPRCLALEVCPL 245
W+ C + + P+
Sbjct: 1018 HQWNPPLAVCRSRSLAPV 1035
Score = 45.4 bits (106), Expect = 1e-04
Identities = 41/132 (31%), Positives = 53/132 (40%), Gaps = 15/132 (11%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ----NLIWSSSPP 235
C P NG IS T VGTVI Y C F+L G L C+ + W P
Sbjct: 23 CGSPPPILNG--RISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 236 RC---LALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYG 292
+C CP P+V G + P Y HG V F C +S+ + K + CQ
Sbjct: 81 KCEYFNKYSSCP-EPIVPGGYKIRGSTP---YRHGDSVTFACKTNFSMNGN-KSVWCQAN 135
Query: 293 E-WFPSYQVYCI 303
W P+ C+
Sbjct: 136 NMWGPTRLPTCV 147
>gi|13540563 complement factor H-related 5 [Homo sapiens]
Length = 569
Score = 71.6 bits (174), Expect = 1e-12
Identities = 64/249 (25%), Positives = 107/249 (42%), Gaps = 24/249 (9%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL-CLKHFNGTLGWIPS 112
L++C+ P + +NG SG + EG + C G+ L+ K + C++ GW
Sbjct: 84 LRMCSFPFV-KNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVER-----GWSTP 137
Query: 113 DNSICVQEDCRIPQIE---DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDG 169
+ +C +P +E DA+ ++Y+ G+ L +C + IR + + C G
Sbjct: 138 PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNL-IR---VGSDSVQCYQFG 193
Query: 170 TWNNLPICQG----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
N P C+G C P SNG V + + V+ Y C P F ++G ++C+
Sbjct: 194 WSPNFPTCKGQVRSCGPPPQLSNGEVK-EIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV 252
Query: 226 QNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYK 285
W++ P ++ C P + +G P Y HG VE C Y++ +
Sbjct: 253 DG-EWTTLPTCVEQVKTCGYIPELEYGYVQPSVPP---YQHGVSVEVNCRNEYAMIGN-N 307
Query: 286 YITCQYGEW 294
ITC G W
Sbjct: 308 MITCINGIW 316
Score = 68.9 bits (167), Expect = 1e-11
Identities = 64/215 (29%), Positives = 99/215 (46%), Gaps = 35/215 (16%)
Query: 34 LWFQLALCFGPAQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKG 93
+W +L +C QL + C G+ SG F S R+ C D F+ +
Sbjct: 315 IWTELPMCVATHQL-------KRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRH 367
Query: 94 ATKRLCLKHFNGTLGWIPSDNSICVQEDCRI----PQIEDAEIHNKT--YRHGEKLIITC 147
+ +C+ NG W P + C ++ + PQI +A+ T Y+ GEK+ + C
Sbjct: 368 S---VCI---NGK--WNPEVD--CTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLC 417
Query: 148 HEGFKIRYPDLHNMVSLCRDDGTWNNLPICQG----CLRPLASSNGYVNISELQTSFPVG 203
E + + P+ +V C+D G W +LP C C P + +NG L +P G
Sbjct: 418 KENYLL--PEAKEIV--CKD-GRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSV-YPPG 471
Query: 204 TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
+ ++YRC +KL GS + C +N W S PPRCL
Sbjct: 472 STVTYRCQSFYKLQGSVTVTC-RNKQW-SEPPRCL 504
Score = 66.2 bits (160), Expect = 6e-11
Identities = 61/237 (25%), Positives = 104/237 (43%), Gaps = 34/237 (14%)
Query: 68 RTPSGGVFFEGSVARFHCQDGFKLKGA---TKRLCLKHFNGTLGWIPSDNSICVQEDCRI 124
+ P+G VF+ + C+ F T+ C + GW P+ + + C
Sbjct: 44 QVPTGEVFY------YSCEYNFVSPSKSFWTRITCTEE-----GWSPTPKCLRM---CSF 89
Query: 125 PQIEDAEIHNKTYRH--GEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQ---- 178
P +++ + H G+ + I C+ G+ ++ +N ++ + W+ PIC
Sbjct: 90 PFVKNGHSESSGLIHLEGDTVQIICNTGYSLQ----NNEKNISCVERGWSTPPICSFTKG 145
Query: 179 GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
C P+ +N V+ + S+ VG V+ + C GS ++C Q WS + P C
Sbjct: 146 ECHVPILEAN--VDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQ-FGWSPNFPTCK 202
Query: 239 A-LEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
+ C PP +S+G+ V R E Y H VVE+ C+P + + K I C GEW
Sbjct: 203 GQVRSCGPPPQLSNGE-VKEIRK-EEYGHNEVVEYDCNPNFIINGP-KKIQCVDGEW 256
Score = 46.2 bits (108), Expect = 7e-05
Identities = 59/283 (20%), Positives = 104/283 (36%), Gaps = 36/283 (12%)
Query: 35 WFQLALCFGPAQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGA 94
W L C + G +L E G+ PS + G +C++ + + G
Sbjct: 256 WTTLPTCVEQVKTCGYIPEL---------EYGYVQPSVPPYQHGVSVEVNCRNEYAMIGN 306
Query: 95 TKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDA---EIHNKTYRHGEKLIITCHEGF 151
C+ NG +P + + C+I + ++ K + H ++ C + F
Sbjct: 307 NMITCI---NGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIF 363
Query: 152 KIRYPDLHNMVSLCRDDGTWNNLPIC-----QGCLRPLASSNGYVNISELQTSFPVGTVI 206
+ R+ S+C + G WN C Q C P N + + ++ G +
Sbjct: 364 RYRH-------SVCIN-GKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTV--NYQDGEKV 413
Query: 207 SYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNH 266
+ C + L + + C W S P + C PP +++GD P Y
Sbjct: 414 AVLCKENYLLPEAKEIVCKDGR-WQSLPRCVESTAYCGPPPSINNGDTTSF--PLSVYPP 470
Query: 267 GTVVEFYCDPGYSLTSDYKYITCQYGEWF--PSYQVYCIKSEQ 307
G+ V + C Y L +TC+ +W P C+ SE+
Sbjct: 471 GSTVTYRCQSFYKLQGSVT-VTCRNKQWSEPPRCLDPCVVSEE 512
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 69.7 bits (169), Expect = 6e-12
Identities = 72/258 (27%), Positives = 105/258 (40%), Gaps = 27/258 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C PG NG + F GS F C +GF L G+T C G +GW +P
Sbjct: 113 CRHPGELRNGQVEIKTDLSF-GSQIEFSCSEGFFLIGSTTSRCEVQDRG-VGWSHPLPQ- 169
Query: 114 NSICVQEDCRIPQIEDAEIHN---KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDD-- 168
C C+ P H+ Y +G + +C F + H +S ++
Sbjct: 170 ---CEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLG---HASISCTVENET 223
Query: 169 -GTWN-NLPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
G W + P C+ C +P S V S + I ++C GF L GS+ + C
Sbjct: 224 IGVWRPSPPTCEKITCRKPDVSHGEMV--SGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC 281
Query: 225 LQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCER--YNHGTVVEFYCDPGYSLTS 282
+ W+ SPP C LP + H + +PRP + Y GTV+ + C PGY T+
Sbjct: 282 DADSKWNPSPPACEPNSCINLPD-IPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTT 340
Query: 283 DY-KYITCQYGEWFPSYQ 299
D + CQ + YQ
Sbjct: 341 DEPTTVICQKNLRWTPYQ 358
Score = 57.8 bits (138), Expect = 2e-08
Identities = 63/269 (23%), Positives = 98/269 (36%), Gaps = 38/269 (14%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + G ++ F CQ GF L+G++ + H + W PS +
Sbjct: 239 CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSS----VIHCDADSKWNPSPPA- 293
Query: 117 CVQEDC-RIPQIEDAE-------IHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDD 168
C C +P I A Y G L CH G+K + ++ C+ +
Sbjct: 294 CEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVI--CQKN 351
Query: 169 GTWNNLPICQGCLRPLASSNGYVNISELQTSFPV-------GTVISYRCFPGFKLDGSAY 221
W C+ P N I++ + S P G IS+ C +
Sbjct: 352 LRWTPYQGCEALCCPEPKLNNG-EITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI-- 408
Query: 222 LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYN-HGTVVEFYCDPGYSL 280
C + WS P C ++C PP ++HG H + Y+ + + CD GY L
Sbjct: 409 --CQGDGTWSPRTPSCG--DICNFPPKIAHG----HYKQSSSYSFFKEEIIYECDKGYIL 460
Query: 281 TSDYKYITCQYGEW---FPSYQVYCIKSE 306
K ++C Y W P + C K E
Sbjct: 461 VGQAK-LSCSYSHWSAPAPQCKALCRKPE 488
Score = 32.3 bits (72), Expect = 1.0
Identities = 19/62 (30%), Positives = 29/62 (46%), Gaps = 3/62 (4%)
Query: 243 CPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQY-GEWFPSYQVY 301
C PP +S + R+ GT +++ C PGY + + +TC GEW Y +
Sbjct: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV--YNTF 107
Query: 302 CI 303
CI
Sbjct: 108 CI 109
>gi|54792787 complement factor H-related 3 [Homo sapiens]
Length = 330
Score = 68.9 bits (167), Expect = 1e-11
Identities = 58/196 (29%), Positives = 91/196 (46%), Gaps = 22/196 (11%)
Query: 108 GWIPSDNSICVQEDCRIPQIEDAEIHN--KTYRHGEKLIITCHEGFKIRYPDLHNMVSLC 165
GW P+ C+++ C P +E+ N + + G + CH G+ + P V+ C
Sbjct: 76 GWSPAVP--CLRK-CYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGL--PKAQTTVT-C 129
Query: 166 RDDGTWNNLPIC---QGCLRP-LASSNGYVNISELQTSFPVGTVISYRCFPGFKL---DG 218
+ G W+ P C + C + + NG+ ISE + + + I Y+C PG+ +
Sbjct: 130 TEKG-WSPTPRCIRVRTCSKSDIEIENGF--ISESSSIYILNKEIQYKCKPGYATADGNS 186
Query: 219 SAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGY 278
S + CLQN WS+ P + E C PP +S+GD + Y + VE+ C P Y
Sbjct: 187 SGSITCLQNG-WSAQPICINSSEKCGPPPPISNGDTTSF--LLKVYVPQSRVEYQCQPYY 243
Query: 279 SLTSDYKYITCQYGEW 294
L Y+TC GEW
Sbjct: 244 ELQGS-NYVTCSNGEW 258
Score = 35.0 bits (79), Expect = 0.15
Identities = 29/99 (29%), Positives = 40/99 (40%), Gaps = 11/99 (11%)
Query: 202 VGTVISYRCFPGFKLDGSAY---LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHP 258
VG SY C F+ +Y + C QN WS + P L C P + +G +
Sbjct: 47 VGKYYSYYCDEHFETPSGSYWDYIHCTQNG-WSPAVP---CLRKCYFP-YLENGYNQNYG 101
Query: 259 RPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPS 297
R ++ G E C PGY L +TC W P+
Sbjct: 102 R---KFVQGNSTEVACHPGYGLPKAQTTVTCTEKGWSPT 137
>gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3
[Homo sapiens]
Length = 840
Score = 67.0 bits (162), Expect = 4e-11
Identities = 59/204 (28%), Positives = 92/204 (45%), Gaps = 28/204 (13%)
Query: 125 PQIEDAEIHNKTYRHGEKL---IIT--CHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ 178
P++ E +T HG+ + ++T C G+++ D + C+ D +W+ P CQ
Sbjct: 575 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD----ILTCQWDLSWSAAPPACQ 630
Query: 179 G---CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WS 231
C P +NG+ S+ FPVG+ + YRC PG+ L+G+A L C WS
Sbjct: 631 KIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWS 688
Query: 232 SSPPRC-LALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
P+C L E C P + +G + Y G + F+C G+ L + ITC
Sbjct: 689 DRVPKCALKYEPCLNPGVPENGYQTLYK---HHYQAGESLRFFCYEGFELIGEVT-ITCV 744
Query: 291 YG---EWFPSYQVYCIKSEQTWPS 311
G +W S C ++ T PS
Sbjct: 745 PGHPSQW-TSQPPLCKVTQTTDPS 767
Score = 56.6 bits (135), Expect = 5e-08
Identities = 33/104 (31%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
+ CADPG NG RT S F GS ++ C G+ L+GA C GT W
Sbjct: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 691
Query: 114 NSICVQ-EDCRIPQIED---AEIHNKTYRHGEKLIITCHEGFKI 153
++ E C P + + ++ Y+ GE L C+EGF++
Sbjct: 692 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFEL 735
Score = 56.2 bits (134), Expect = 6e-08
Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 22/194 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C + PE G+RT S G G+V + C+ G++L G+ C L W + +
Sbjct: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 629
Query: 117 CVQEDCRIPQIEDAEIHNKT----YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT-- 170
C P E A H + G + C G+ + + + RD GT
Sbjct: 630 QKIMTCADPG-EIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAM--LTCYSRDTGTPK 686
Query: 171 WNN-LPIC----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W++ +P C + CL P NGY + + + G + + C+ GF+L G + C+
Sbjct: 687 WSDRVPKCALKYEPCLNPGVPENGYQTL--YKHHYQAGESLRFFCYEGFELIGEVTITCV 744
Query: 226 QN--LIWSSSPPRC 237
W+S PP C
Sbjct: 745 PGHPSQWTSQPPLC 758
Score = 31.2 bits (69), Expect = 2.2
Identities = 19/62 (30%), Positives = 31/62 (50%), Gaps = 6/62 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL--IWSSSPPRC 237
C P ++G V++++L P GT ++ C G++L G L CL W+ P C
Sbjct: 220 CGFPPRPAHGDVSVTDLH---PGGTA-TFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
Query: 238 LA 239
+A
Sbjct: 276 MA 277
Score = 30.0 bits (66), Expect = 5.0
Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 3/29 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGT 106
G A FHC G++L+G +CL NGT
Sbjct: 239 GGTATFHCDSGYQLQGEETLICL---NGT 264
>gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2
[Homo sapiens]
Length = 910
Score = 67.0 bits (162), Expect = 4e-11
Identities = 59/204 (28%), Positives = 92/204 (45%), Gaps = 28/204 (13%)
Query: 125 PQIEDAEIHNKTYRHGEKL---IIT--CHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ 178
P++ E +T HG+ + ++T C G+++ D + C+ D +W+ P CQ
Sbjct: 645 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD----ILTCQWDLSWSAAPPACQ 700
Query: 179 G---CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WS 231
C P +NG+ S+ FPVG+ + YRC PG+ L+G+A L C WS
Sbjct: 701 KIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWS 758
Query: 232 SSPPRC-LALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
P+C L E C P + +G + Y G + F+C G+ L + ITC
Sbjct: 759 DRVPKCALKYEPCLNPGVPENGYQTLYK---HHYQAGESLRFFCYEGFELIGEVT-ITCV 814
Query: 291 YG---EWFPSYQVYCIKSEQTWPS 311
G +W S C ++ T PS
Sbjct: 815 PGHPSQW-TSQPPLCKVTQTTDPS 837
Score = 56.6 bits (135), Expect = 5e-08
Identities = 33/104 (31%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
+ CADPG NG RT S F GS ++ C G+ L+GA C GT W
Sbjct: 702 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 761
Query: 114 NSICVQ-EDCRIPQIED---AEIHNKTYRHGEKLIITCHEGFKI 153
++ E C P + + ++ Y+ GE L C+EGF++
Sbjct: 762 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFEL 805
Score = 56.2 bits (134), Expect = 6e-08
Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 22/194 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C + PE G+RT S G G+V + C+ G++L G+ C L W + +
Sbjct: 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 699
Query: 117 CVQEDCRIPQIEDAEIHNKT----YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT-- 170
C P E A H + G + C G+ + + + RD GT
Sbjct: 700 QKIMTCADPG-EIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAM--LTCYSRDTGTPK 756
Query: 171 WNN-LPIC----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W++ +P C + CL P NGY + + + G + + C+ GF+L G + C+
Sbjct: 757 WSDRVPKCALKYEPCLNPGVPENGYQTL--YKHHYQAGESLRFFCYEGFELIGEVTITCV 814
Query: 226 QN--LIWSSSPPRC 237
W+S PP C
Sbjct: 815 PGHPSQWTSQPPLC 828
Score = 31.2 bits (69), Expect = 2.2
Identities = 19/62 (30%), Positives = 31/62 (50%), Gaps = 6/62 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL--IWSSSPPRC 237
C P ++G V++++L P GT ++ C G++L G L CL W+ P C
Sbjct: 290 CGFPPRPAHGDVSVTDLH---PGGTA-TFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345
Query: 238 LA 239
+A
Sbjct: 346 MA 347
Score = 30.0 bits (66), Expect = 5.0
Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 3/29 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGT 106
G A FHC G++L+G +CL NGT
Sbjct: 309 GGTATFHCDSGYQLQGEETLICL---NGT 334
>gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4
[Homo sapiens]
Length = 809
Score = 65.9 bits (159), Expect = 8e-11
Identities = 53/182 (29%), Positives = 83/182 (45%), Gaps = 24/182 (13%)
Query: 125 PQIEDAEIHNKTYRHGEKL---IIT--CHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ 178
P++ E +T HG+ + ++T C G+++ D + C+ D +W+ P CQ
Sbjct: 531 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD----ILTCQWDLSWSAAPPACQ 586
Query: 179 G---CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WS 231
C P +NG+ S+ FPVG+ + YRC PG+ L+G+A L C WS
Sbjct: 587 KIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWS 644
Query: 232 SSPPRC-LALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
P+C L E C P + +G + Y G + F+C G+ L + ITC
Sbjct: 645 DRVPKCALKYEPCLNPGVPENGYQTLYK---HHYQAGESLRFFCYEGFELIGEVT-ITCV 700
Query: 291 YG 292
G
Sbjct: 701 PG 702
Score = 56.6 bits (135), Expect = 5e-08
Identities = 33/104 (31%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
+ CADPG NG RT S F GS ++ C G+ L+GA C GT W
Sbjct: 588 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 647
Query: 114 NSICVQ-EDCRIPQIED---AEIHNKTYRHGEKLIITCHEGFKI 153
++ E C P + + ++ Y+ GE L C+EGF++
Sbjct: 648 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFEL 691
Score = 56.2 bits (134), Expect = 6e-08
Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 22/194 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C + PE G+RT S G G+V + C+ G++L G+ C L W + +
Sbjct: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 585
Query: 117 CVQEDCRIPQIEDAEIHNKT----YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT-- 170
C P E A H + G + C G+ + + + RD GT
Sbjct: 586 QKIMTCADPG-EIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAM--LTCYSRDTGTPK 642
Query: 171 WNN-LPIC----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W++ +P C + CL P NGY + + + G + + C+ GF+L G + C+
Sbjct: 643 WSDRVPKCALKYEPCLNPGVPENGYQTL--YKHHYQAGESLRFFCYEGFELIGEVTITCV 700
Query: 226 QN--LIWSSSPPRC 237
W+S PP C
Sbjct: 701 PGHPSQWTSQPPLC 714
Score = 31.2 bits (69), Expect = 2.2
Identities = 19/62 (30%), Positives = 31/62 (50%), Gaps = 6/62 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL--IWSSSPPRC 237
C P ++G V++++L P GT ++ C G++L G L CL W+ P C
Sbjct: 176 CGFPPRPAHGDVSVTDLH---PGGTA-TFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
Query: 238 LA 239
+A
Sbjct: 232 MA 233
Score = 30.0 bits (66), Expect = 5.0
Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 3/29 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGT 106
G A FHC G++L+G +CL NGT
Sbjct: 195 GGTATFHCDSGYQLQGEETLICL---NGT 220
>gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [Homo
sapiens]
Length = 853
Score = 65.9 bits (159), Expect = 8e-11
Identities = 53/182 (29%), Positives = 83/182 (45%), Gaps = 24/182 (13%)
Query: 125 PQIEDAEIHNKTYRHGEKL---IIT--CHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ 178
P++ E +T HG+ + ++T C G+++ D + C+ D +W+ P CQ
Sbjct: 575 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD----ILTCQWDLSWSAAPPACQ 630
Query: 179 G---CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WS 231
C P +NG+ S+ FPVG+ + YRC PG+ L+G+A L C WS
Sbjct: 631 KIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWS 688
Query: 232 SSPPRC-LALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQ 290
P+C L E C P + +G + Y G + F+C G+ L + ITC
Sbjct: 689 DRVPKCALKYEPCLNPGVPENGYQTLYK---HHYQAGESLRFFCYEGFELIGEVT-ITCV 744
Query: 291 YG 292
G
Sbjct: 745 PG 746
Score = 56.6 bits (135), Expect = 5e-08
Identities = 33/104 (31%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
+ CADPG NG RT S F GS ++ C G+ L+GA C GT W
Sbjct: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 691
Query: 114 NSICVQ-EDCRIPQIED---AEIHNKTYRHGEKLIITCHEGFKI 153
++ E C P + + ++ Y+ GE L C+EGF++
Sbjct: 692 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFEL 735
Score = 56.2 bits (134), Expect = 6e-08
Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 22/194 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C + PE G+RT S G G+V + C+ G++L G+ C L W + +
Sbjct: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 629
Query: 117 CVQEDCRIPQIEDAEIHNKT----YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT-- 170
C P E A H + G + C G+ + + + RD GT
Sbjct: 630 QKIMTCADPG-EIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAM--LTCYSRDTGTPK 686
Query: 171 WNN-LPIC----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W++ +P C + CL P NGY + + + G + + C+ GF+L G + C+
Sbjct: 687 WSDRVPKCALKYEPCLNPGVPENGYQTL--YKHHYQAGESLRFFCYEGFELIGEVTITCV 744
Query: 226 QN--LIWSSSPPRC 237
W+S PP C
Sbjct: 745 PGHPSQWTSQPPLC 758
Score = 31.2 bits (69), Expect = 2.2
Identities = 19/62 (30%), Positives = 31/62 (50%), Gaps = 6/62 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL--IWSSSPPRC 237
C P ++G V++++L P GT ++ C G++L G L CL W+ P C
Sbjct: 220 CGFPPRPAHGDVSVTDLH---PGGTA-TFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
Query: 238 LA 239
+A
Sbjct: 276 MA 277
Score = 30.0 bits (66), Expect = 5.0
Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 3/29 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGT 106
G A FHC G++L+G +CL NGT
Sbjct: 239 GGTATFHCDSGYQLQGEETLICL---NGT 264
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 64.3 bits (155), Expect = 2e-10
Identities = 55/236 (23%), Positives = 96/236 (40%), Gaps = 37/236 (15%)
Query: 77 EGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN-SICVQEDCRIPQIEDAEIHNK 135
EG+ A + C+ G++ G +C K W+ + C + C P
Sbjct: 44 EGTQAIYKCRPGYRSLGNVIMVCRKG-----EWVALNPLRKCQKRPCGHPGDTPFGTFTL 98
Query: 136 T----YRHGEKLIITCHEGFK----IRYPDLHNMVSLCRDDGTWNNLPICQ--GCLRPLA 185
T + +G K + TC+EG++ I Y + C DG N++PIC+ CL A
Sbjct: 99 TGGNVFEYGVKAVYTCNEGYQLLGEINYRE-------CDTDGWTNDIPICEVVKCLPVTA 151
Query: 186 SSNGYVNISELQTS--FPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVC 243
NG + S ++ + G + + C G+K++G + C + WS P+C+ + C
Sbjct: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEIS-C 210
Query: 244 PLPPMVSHGDFVCHPRPCER---YNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFP 296
P +++ P + Y ++ C+ GY S+ C W P
Sbjct: 211 KSPDVINGS-------PISQKIIYKENERFQYKCNMGYEY-SERGDAVCTESGWRP 258
Score = 59.3 bits (142), Expect = 8e-09
Identities = 60/250 (24%), Positives = 97/250 (38%), Gaps = 29/250 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + NG ++ E ++ C G++ +C + GW P +
Sbjct: 210 CKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTES-----GWRPLPS-- 261
Query: 117 CVQEDCRIPQIEDAEIHNKTYRH--GEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
C ++ C P I + + +H G+++ C GF YP + C G W
Sbjct: 262 CEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGF---YPATRGNTAKCTSTG-WIPA 317
Query: 175 PIC--QGCLRPLASSNGYVNISELQTSFPV--GTVISYRCFPGFKLDGSAY---LECLQN 227
P C + C P G + + + FPV G SY C F+ +Y + C Q+
Sbjct: 318 PRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQD 377
Query: 228 LIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYI 287
WS + P L C P + +G H R ++ G ++ C PGY+L +
Sbjct: 378 G-WSPAVP---CLRKCYFP-YLENGYNQNHGR---KFVQGKSIDVACHPGYALPKAQTTV 429
Query: 288 TCQYGEWFPS 297
TC W P+
Sbjct: 430 TCMENGWSPT 439
Score = 39.7 bits (91), Expect = 0.006
Identities = 23/96 (23%), Positives = 38/96 (39%), Gaps = 2/96 (2%)
Query: 199 SFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHP 258
++P GT Y+C PG++ G+ + C + + +P R C P G F
Sbjct: 41 TYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTL-- 98
Query: 259 RPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294
+ +G + C+ GY L + Y C W
Sbjct: 99 TGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGW 134
>gi|148839346 seizure related 6 homolog isoform 2 [Homo sapiens]
Length = 993
Score = 57.8 bits (138), Expect = 2e-08
Identities = 44/150 (29%), Positives = 67/150 (44%), Gaps = 15/150 (10%)
Query: 139 HGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NLPICQ---GCLRPLASSNGYVNIS 194
HG + C+ G+++ + + V +C+ D TW+ +LP CQ C P + IS
Sbjct: 730 HGTVVTYQCYPGYQV----VGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLIS 785
Query: 195 ELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WSSSPPRCLALEVCPLPPMVS 250
FPVG + Y C GF L GS+ L C WS P+CL ++ P + +
Sbjct: 786 S--PKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSA 843
Query: 251 HGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
+ P + + G + F C PGY L
Sbjct: 844 PENGARSPEK-QLHPAGATIHFSCAPGYVL 872
Score = 56.2 bits (134), Expect = 6e-08
Identities = 29/88 (32%), Positives = 46/88 (52%), Gaps = 6/88 (6%)
Query: 203 GTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHG-DFVCHPRPC 261
GTV++Y+C+PG+++ GS+ L C +L WS P C + C P V H + P
Sbjct: 731 GTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSP--- 787
Query: 262 ERYNHGTVVEFYCDPGYSLTSDYKYITC 289
++ G V++ CD G+ L +TC
Sbjct: 788 -KFPVGATVQYICDQGFVLMGS-SILTC 813
Score = 50.4 bits (119), Expect = 4e-06
Identities = 49/197 (24%), Positives = 81/197 (41%), Gaps = 27/197 (13%)
Query: 60 PGIPE--NGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSDN 114
P +PE NG+++PS G+V + C G+++ G++ +C L W +PS
Sbjct: 711 PELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMC----QWDLTWSEDLPSCQ 766
Query: 115 SICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRD----DGT 170
+ D + I + + G + C +GF + + + + C D
Sbjct: 767 RVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVL----MGSSILTCHDRQAGSPK 822
Query: 171 WNN-LPIC-----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
W++ P C + C A NG S + P G I + C PG+ L G A ++C
Sbjct: 823 WSDRAPKCLLEQLKPCHGLSAPENG--ARSPEKQLHPAGATIHFSCAPGYVLKGQASIKC 880
Query: 225 LQN--LIWSSSPPRCLA 239
+ WS PP C A
Sbjct: 881 VPGHPSHWSDPPPICRA 897
Score = 47.4 bits (111), Expect = 3e-05
Identities = 64/244 (26%), Positives = 87/244 (35%), Gaps = 45/244 (18%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCR--IPQIEDAEIHNK 135
G ARFHC G++LKGA CL N T + S +C+ C I I +
Sbjct: 376 GGSARFHCATGYQLKGARHLTCL---NATQPFWDSKEPVCIAA-CGGVIRNATTGRIVSP 431
Query: 136 TYRHGEKLIITCH------EGFKIRYPDLH-NMVSLCRDDGTWNNLPICQGCLRPLASSN 188
+ +TCH EG ++ LH VSL DD R + +
Sbjct: 432 GFPGNYSNNLTCHWLLEAPEGQRLH---LHFEKVSLAEDDD------------RLIIRNG 476
Query: 189 GYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCP---- 244
V + S+ V Y G G + L ++ L E
Sbjct: 477 DNVEAPPVYDSYEV----EYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHC 532
Query: 245 LPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITC------QYGEWFPSY 298
P V +G+F Y GT VEF CDPGY+L I C Q+ E P+
Sbjct: 533 YEPFVKYGNF---SSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPAC 589
Query: 299 QVYC 302
+ C
Sbjct: 590 RAVC 593
Score = 34.3 bits (77), Expect = 0.26
Identities = 16/49 (32%), Positives = 23/49 (46%)
Query: 52 DDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+ L+ C PENG R+P + G+ F C G+ LKG C+
Sbjct: 833 EQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCV 881
Score = 31.6 bits (70), Expect = 1.7
Identities = 17/53 (32%), Positives = 24/53 (45%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW 109
C DPG E+ R S F G+ ++ C GF L G++ C G+ W
Sbjct: 771 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKW 823
Score = 30.8 bits (68), Expect = 2.9
Identities = 15/44 (34%), Positives = 21/44 (47%), Gaps = 2/44 (4%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECLQ--NLIWSSSPPRCLA 239
TS G + C G++L G+ +L CL W S P C+A
Sbjct: 371 TSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIA 414
>gi|148839280 seizure related 6 homolog isoform 1 [Homo sapiens]
Length = 994
Score = 57.8 bits (138), Expect = 2e-08
Identities = 44/150 (29%), Positives = 67/150 (44%), Gaps = 15/150 (10%)
Query: 139 HGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NLPICQ---GCLRPLASSNGYVNIS 194
HG + C+ G+++ + + V +C+ D TW+ +LP CQ C P + IS
Sbjct: 730 HGTVVTYQCYPGYQV----VGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLIS 785
Query: 195 ELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WSSSPPRCLALEVCPLPPMVS 250
FPVG + Y C GF L GS+ L C WS P+CL ++ P + +
Sbjct: 786 S--PKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSA 843
Query: 251 HGDFVCHPRPCERYNHGTVVEFYCDPGYSL 280
+ P + + G + F C PGY L
Sbjct: 844 PENGARSPEK-QLHPAGATIHFSCAPGYVL 872
Score = 56.2 bits (134), Expect = 6e-08
Identities = 29/88 (32%), Positives = 46/88 (52%), Gaps = 6/88 (6%)
Query: 203 GTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHG-DFVCHPRPC 261
GTV++Y+C+PG+++ GS+ L C +L WS P C + C P V H + P
Sbjct: 731 GTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSP--- 787
Query: 262 ERYNHGTVVEFYCDPGYSLTSDYKYITC 289
++ G V++ CD G+ L +TC
Sbjct: 788 -KFPVGATVQYICDQGFVLMGS-SILTC 813
Score = 50.4 bits (119), Expect = 4e-06
Identities = 49/197 (24%), Positives = 81/197 (41%), Gaps = 27/197 (13%)
Query: 60 PGIPE--NGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSDN 114
P +PE NG+++PS G+V + C G+++ G++ +C L W +PS
Sbjct: 711 PELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMC----QWDLTWSEDLPSCQ 766
Query: 115 SICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRD----DGT 170
+ D + I + + G + C +GF + + + + C D
Sbjct: 767 RVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVL----MGSSILTCHDRQAGSPK 822
Query: 171 WNN-LPIC-----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
W++ P C + C A NG S + P G I + C PG+ L G A ++C
Sbjct: 823 WSDRAPKCLLEQLKPCHGLSAPENG--ARSPEKQLHPAGATIHFSCAPGYVLKGQASIKC 880
Query: 225 LQN--LIWSSSPPRCLA 239
+ WS PP C A
Sbjct: 881 VPGHPSHWSDPPPICRA 897
Score = 47.4 bits (111), Expect = 3e-05
Identities = 64/244 (26%), Positives = 87/244 (35%), Gaps = 45/244 (18%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCR--IPQIEDAEIHNK 135
G ARFHC G++LKGA CL N T + S +C+ C I I +
Sbjct: 376 GGSARFHCATGYQLKGARHLTCL---NATQPFWDSKEPVCIAA-CGGVIRNATTGRIVSP 431
Query: 136 TYRHGEKLIITCH------EGFKIRYPDLH-NMVSLCRDDGTWNNLPICQGCLRPLASSN 188
+ +TCH EG ++ LH VSL DD R + +
Sbjct: 432 GFPGNYSNNLTCHWLLEAPEGQRLH---LHFEKVSLAEDDD------------RLIIRNG 476
Query: 189 GYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCP---- 244
V + S+ V Y G G + L ++ L E
Sbjct: 477 DNVEAPPVYDSYEV----EYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHC 532
Query: 245 LPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITC------QYGEWFPSY 298
P V +G+F Y GT VEF CDPGY+L I C Q+ E P+
Sbjct: 533 YEPFVKYGNF---SSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPAC 589
Query: 299 QVYC 302
+ C
Sbjct: 590 RAVC 593
Score = 34.3 bits (77), Expect = 0.26
Identities = 16/49 (32%), Positives = 23/49 (46%)
Query: 52 DDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+ L+ C PENG R+P + G+ F C G+ LKG C+
Sbjct: 833 EQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCV 881
Score = 31.6 bits (70), Expect = 1.7
Identities = 17/53 (32%), Positives = 24/53 (45%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW 109
C DPG E+ R S F G+ ++ C GF L G++ C G+ W
Sbjct: 771 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKW 823
Score = 30.8 bits (68), Expect = 2.9
Identities = 15/44 (34%), Positives = 21/44 (47%), Gaps = 2/44 (4%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECLQ--NLIWSSSPPRCLA 239
TS G + C G++L G+ +L CL W S P C+A
Sbjct: 371 TSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIA 414
>gi|118442839 complement factor H-related 1 [Homo sapiens]
Length = 330
Score = 56.6 bits (135), Expect = 5e-08
Identities = 61/238 (25%), Positives = 101/238 (42%), Gaps = 22/238 (9%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL-CLKHFNGTLGWIPS 112
L++C P + ENG SG EG + C G++L+ + C++ T S
Sbjct: 84 LRLCFFPFV-ENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRS 142
Query: 113 DNSICVQEDCRIPQIEDAEIHNK---TYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDG 169
++ CV P +++A I ++ Y GE++ C +++ + D M +G
Sbjct: 143 TDTSCVNP----PTVQNAHILSRQMSKYPSGERVRYECRSPYEM-FGDEEVMCL----NG 193
Query: 170 TWNNLPICQG----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W P C+ C P NG + L P +V Y+C ++L+G+ + C
Sbjct: 194 NWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSV-EYQCQNLYQLEGNKRITC- 251
Query: 226 QNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERY-NHGTVVEFYCDPGYSLTS 282
+N W S PP+CL V M ++ + + Y G EF C GY L+S
Sbjct: 252 RNGQW-SEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSS 308
>gi|239758113 PREDICTED: similar to complement factor H-related 1
isoform 1 [Homo sapiens]
Length = 330
Score = 56.6 bits (135), Expect = 5e-08
Identities = 61/238 (25%), Positives = 101/238 (42%), Gaps = 22/238 (9%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL-CLKHFNGTLGWIPS 112
L++C P + ENG SG EG + C G++L+ + C++ T S
Sbjct: 84 LRLCFFPFV-ENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRS 142
Query: 113 DNSICVQEDCRIPQIEDAEIHNK---TYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDG 169
++ CV P +++A I ++ Y GE++ C +++ + D M +G
Sbjct: 143 TDTSCVNP----PTVQNAHILSRQMSKYPSGERVRYECRSPYEM-FGDEEVMCL----NG 193
Query: 170 TWNNLPICQG----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W P C+ C P NG + L P +V Y+C ++L+G+ + C
Sbjct: 194 NWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSV-EYQCQNLYQLEGNKRITC- 251
Query: 226 QNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERY-NHGTVVEFYCDPGYSLTS 282
+N W S PP+CL V M ++ + + Y G EF C GY L+S
Sbjct: 252 RNGQW-SEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSS 308
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.138 0.446
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,770,888
Number of Sequences: 37866
Number of extensions: 1283863
Number of successful extensions: 6504
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 5268
Number of HSP's gapped (non-prelim): 685
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.