Search of human proteins with 14790190

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14790190 spen homolog, transcriptional regulator [Homo
sapiens]
         (3664 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]   7260   0.0  
gi|91982772 mucin 17 [Homo sapiens]                                   143   3e-33
gi|163965366 nascent polypeptide-associated complex alpha subuni...   134   1e-30
gi|116284392 mucin 2 precursor [Homo sapiens]                         130   2e-29
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]    123   3e-27
gi|47933339 RNA binding motif protein 15 [Homo sapiens]               122   5e-27
gi|54607124 RNA binding motif protein 15B [Homo sapiens]              113   3e-24
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   111   1e-23
gi|110349719 titin isoform N2-A [Homo sapiens]                        110   3e-23
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit...   108   1e-22
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                  107   3e-22
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                   107   3e-22
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]       106   5e-22
gi|148746195 trichohyalin [Homo sapiens]                              105   8e-22
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...   102   7e-21
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]             100   3e-20
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         99   8e-20
gi|167736355 mucin 4 isoform a [Homo sapiens]                          97   3e-19
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]        97   4e-19
gi|239743293 PREDICTED: mucin 12 [Homo sapiens]                        96   9e-19
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   95   1e-18
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   95   1e-18
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    94   2e-18
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          93   6e-18
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    91   2e-17
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    90   4e-17
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa...    88   2e-16
gi|169205253 PREDICTED: hypothetical protein [Homo sapiens]            87   3e-16
gi|239508976 PREDICTED: mucin 12, cell surface associated [Homo ...    87   3e-16
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa...    87   4e-16

>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
          Length = 3664

 Score = 7261 bits (18838), Expect = 0.0
 Identities = 3664/3664 (100%), Positives = 3664/3664 (100%)

Query: 1    MVRETRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQ 60
            MVRETRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQ
Sbjct: 1    MVRETRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQ 60

Query: 61   KAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPP 120
            KAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPP
Sbjct: 61   KAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPP 120

Query: 121  SLHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQH 180
            SLHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQH
Sbjct: 121  SLHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQH 180

Query: 181  GLYYASRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHS 240
            GLYYASRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHS
Sbjct: 181  GLYYASRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHS 240

Query: 241  RSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSS 300
            RSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSS
Sbjct: 241  RSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSS 300

Query: 301  SSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEFK 360
            SSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEFK
Sbjct: 301  SSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEFK 360

Query: 361  KFGKVTSVQIHGTSEERYGLVFFRQQEDQEKALTASKGKLFFGMQIEVTAWIGPETESEN 420
            KFGKVTSVQIHGTSEERYGLVFFRQQEDQEKALTASKGKLFFGMQIEVTAWIGPETESEN
Sbjct: 361  KFGKVTSVQIHGTSEERYGLVFFRQQEDQEKALTASKGKLFFGMQIEVTAWIGPETESEN 420

Query: 421  EFRPLDERIDEFHPKATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAF 480
            EFRPLDERIDEFHPKATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAF
Sbjct: 421  EFRPLDERIDEFHPKATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAF 480

Query: 481  LQYCDIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRY 540
            LQYCDIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRY
Sbjct: 481  LQYCDIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRY 540

Query: 541  GPVVKVVFDRLKGMALVLYNEIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCME 600
            GPVVKVVFDRLKGMALVLYNEIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCME
Sbjct: 541  GPVVKVVFDRLKGMALVLYNEIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCME 600

Query: 601  KSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYPARGREFYSE 660
            KSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYPARGREFYSE
Sbjct: 601  KSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYPARGREFYSE 660

Query: 661  WETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERR 720
            WETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERR
Sbjct: 661  WETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERR 720

Query: 721  PIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKS 780
            PIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKS
Sbjct: 721  PIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKS 780

Query: 781  RLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQ 840
            RLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQ
Sbjct: 781  RLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQ 840

Query: 841  ENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLK 900
            ENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLK
Sbjct: 841  ENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLK 900

Query: 901  AKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKA 960
            AKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKA
Sbjct: 901  AKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKA 960

Query: 961  RKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQP 1020
            RKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQP
Sbjct: 961  RKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQP 1020

Query: 1021 DVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRP 1080
            DVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRP
Sbjct: 1021 DVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRP 1080

Query: 1081 SSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDET 1140
            SSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDET
Sbjct: 1081 SSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDET 1140

Query: 1141 PERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVD 1200
            PERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVD
Sbjct: 1141 PERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVD 1200

Query: 1201 EYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGG 1260
            EYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGG
Sbjct: 1201 EYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGG 1260

Query: 1261 SPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQM 1320
            SPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQM
Sbjct: 1261 SPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQM 1320

Query: 1321 ADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPS 1380
            ADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPS
Sbjct: 1321 ADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPS 1380

Query: 1381 DSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTI 1440
            DSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTI
Sbjct: 1381 DSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTI 1440

Query: 1441 TPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKI 1500
            TPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKI
Sbjct: 1441 TPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKI 1500

Query: 1501 RTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRI 1560
            RTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRI
Sbjct: 1501 RTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRI 1560

Query: 1561 YGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTP 1620
            YGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTP
Sbjct: 1561 YGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTP 1620

Query: 1621 ESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVS 1680
            ESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVS
Sbjct: 1621 ESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVS 1680

Query: 1681 EEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGA 1740
            EEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGA
Sbjct: 1681 EEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGA 1740

Query: 1741 SFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPP 1800
            SFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPP
Sbjct: 1741 SFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPP 1800

Query: 1801 ASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRG 1860
            ASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRG
Sbjct: 1801 ASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRG 1860

Query: 1861 EAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPV 1920
            EAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPV
Sbjct: 1861 EAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPV 1920

Query: 1921 KEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEG 1980
            KEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEG
Sbjct: 1921 KEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEG 1980

Query: 1981 WRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSE 2040
            WRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSE
Sbjct: 1981 WRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSE 2040

Query: 2041 QKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAV 2100
            QKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAV
Sbjct: 2041 QKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAV 2100

Query: 2101 SPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSP 2160
            SPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSP
Sbjct: 2101 SPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSP 2160

Query: 2161 EATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIG 2220
            EATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIG
Sbjct: 2161 EATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIG 2220

Query: 2221 SIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATE 2280
            SIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATE
Sbjct: 2221 SIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATE 2280

Query: 2281 SSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRR 2340
            SSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRR
Sbjct: 2281 SSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRR 2340

Query: 2341 KRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTS 2400
            KRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTS
Sbjct: 2341 KRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTS 2400

Query: 2401 DLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVT 2460
            DLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVT
Sbjct: 2401 DLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVT 2460

Query: 2461 PPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPP 2520
            PPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPP
Sbjct: 2461 PPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPP 2520

Query: 2521 DTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKK 2580
            DTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKK
Sbjct: 2521 DTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKK 2580

Query: 2581 PLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLA 2640
            PLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLA
Sbjct: 2581 PLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLA 2640

Query: 2641 KPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVL 2700
            KPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVL
Sbjct: 2641 KPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVL 2700

Query: 2701 TGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTV 2760
            TGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTV
Sbjct: 2701 TGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTV 2760

Query: 2761 TMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYS 2820
            TMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYS
Sbjct: 2761 TMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYS 2820

Query: 2821 GQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANV 2880
            GQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANV
Sbjct: 2821 GQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANV 2880

Query: 2881 ATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPP 2940
            ATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPP
Sbjct: 2881 ATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPP 2940

Query: 2941 VLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNH 3000
            VLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNH
Sbjct: 2941 VLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNH 3000

Query: 3001 VPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAA 3060
            VPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAA
Sbjct: 3001 VPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAA 3060

Query: 3061 GIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSP 3120
            GIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSP
Sbjct: 3061 GIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSP 3120

Query: 3121 RAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVM 3180
            RAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVM
Sbjct: 3121 RAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVM 3180

Query: 3181 QSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAK 3240
            QSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAK
Sbjct: 3181 QSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAK 3240

Query: 3241 AAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSG 3300
            AAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSG
Sbjct: 3241 AAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSG 3300

Query: 3301 ELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQST 3360
            ELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQST
Sbjct: 3301 ELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQST 3360

Query: 3361 QPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQ 3420
            QPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQ
Sbjct: 3361 QPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQ 3420

Query: 3421 RAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQP 3480
            RAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQP
Sbjct: 3421 RAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQP 3480

Query: 3481 APKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRSLPL 3540
            APKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRSLPL
Sbjct: 3481 APKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRSLPL 3540

Query: 3541 SEGGPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFI 3600
            SEGGPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFI
Sbjct: 3541 SEGGPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFI 3600

Query: 3601 TYLQAKQAAGIINVPNPGSNQPAYVLQIFPPCEFSESHLSRLAPDLLASISNISPHLMIV 3660
            TYLQAKQAAGIINVPNPGSNQPAYVLQIFPPCEFSESHLSRLAPDLLASISNISPHLMIV
Sbjct: 3601 TYLQAKQAAGIINVPNPGSNQPAYVLQIFPPCEFSESHLSRLAPDLLASISNISPHLMIV 3660

Query: 3661 IASV 3664
            IASV
Sbjct: 3661 IASV 3664


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score =  143 bits (361), Expect = 3e-33
 Identities = 420/2051 (20%), Positives = 660/2051 (32%), Gaps = 268/2051 (13%)

Query: 1619 TPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKT----V 1674
            TP S      SE+ T       + T+VT  + PS+L  T    ++    ++E  T    +
Sbjct: 339  TPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNM 398

Query: 1675 EPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAK 1734
              +T+   +  AS  +  PV+    V          EA+  P   E+ S     P   + 
Sbjct: 399  PVSTILVASSEASTTSTIPVDSKTFVTTA------SEASSSPTTAEDTSIATSTPSEGST 452

Query: 1735 PPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAA 1794
            P T     +   ++ +    ST P+    Q +  + E  +  P A  ++ P +     + 
Sbjct: 453  PLTSMPVSTTPVASSEASNLSTTPVDSKTQVT-TSTEASSSPPTAEVNSMPTSTPSEGST 511

Query: 1795 P------ESQPPASEDLEV--DPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSER 1846
            P       + P AS +       PV         S+ S +       SI     +  S  
Sbjct: 512  PLTSMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTP 571

Query: 1847 IDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNV-- 1904
            +    +        EA        ++     T+S+ S++       S+P S    R    
Sbjct: 572  LTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTI 631

Query: 1905 --RSVYATMGDHENRS-----PVKEPVEQPRVTRKRLERELQEAAAVPT-------TPRR 1950
               SV  T+      S     PV         T         E  ++PT       TP  
Sbjct: 632  TSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLT 691

Query: 1951 GRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNE------- 2003
              P  T   A  E    +  P +T  P        S  T A G        +E       
Sbjct: 692  SMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTS 751

Query: 2004 -------------------PKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAG------ 2038
                               P   +T    +TE        E +  P +   E        
Sbjct: 752  MPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSI 811

Query: 2039 --------SEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKS 2090
                    S +         D N P T   E V   P P + +          R  +  S
Sbjct: 812  PVSITPVTSPEASTLSTTPVDSNSPVTTSTE-VSSSPTPAEGTSMPTSTYSEGRTPL-TS 869

Query: 2091 ASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLK-----SDPVDPD 2145
              +     A S     +      S  V  S E   SP   +G S         S P+   
Sbjct: 870  MPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEGSTPLTSM 929

Query: 2146 KEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDK 2205
             +     VS+   +  AT +     +  + E  +    A  ++   +   EG  P     
Sbjct: 930  PDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTP 989

Query: 2206 PAHQASETELAAAIGSIIND----ISGEPENFPAPPPYPGESQTDLQPPAGAQAL--QPS 2259
             +H       A+ + +   D    ++   E    PP   G S     P  G+  L   P 
Sbjct: 990  VSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPV 1049

Query: 2260 EEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSK 2319
               M      S +  T A T +   PV     ++  + T +     + T         S 
Sbjct: 1050 STTMVASSETSTLSTTPADTST---PVTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSV 1106

Query: 2320 EVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQ-GESPAANEGTTVQHP 2378
             V   LV   +    +T              PV++ +P +   +   SP   EGT++  P
Sbjct: 1107 PVSTRLVVSSEASTLST-------------TPVDTSIPVTTSTEASSSPTTAEGTSI--P 1151

Query: 2379 EAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQ-EISVEERTPTKASVPP------DL 2431
             +P  E     P ++ P S T  +S   +T +++  +   +  T T+AS PP       +
Sbjct: 1152 TSPPSE--GTTPLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSM 1209

Query: 2432 P---PPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGG 2488
            P   P  +  P+   P     V S   S   T P D S P+ T    ++   SP  A G 
Sbjct: 1210 PTSTPGERSTPLTSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAETSS---SPTTAEG- 1265

Query: 2489 IPHQSPPTKVTE--------------WITRQEEPRAQSTPSPALPPDTKASDVDTSSSTL 2534
                S PT  T                +T  E     +TP     P   +++V +S +  
Sbjct: 1266 ---TSLPTSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPA 1322

Query: 2535 RKILMDPKYVS--ATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKT---APP 2589
                M     S   T +TS  V T +     A+  +      PVD+  P+   T   + P
Sbjct: 1323 EGTSMPTSTYSEGRTPLTSIPVNTTLV----ASSAISILSTTPVDNSTPVTTSTEACSSP 1378

Query: 2590 VTN------NSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPA 2643
             T+      NS        + +      PV++ +  S +S  PV      +     A  +
Sbjct: 1379 TTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSE-ASTLSATPVDTSTPGTTSAE-ATSS 1436

Query: 2644 PQTLTGLVSALTGLVNVSLVPVNAL---KGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVL 2700
            P T  G +S  T   +    P+ ++     PV  S  +  S     +    V    V+  
Sbjct: 1437 PTTAEG-ISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVSSS 1495

Query: 2701 TGPVN----VLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTA---ASGGV 2753
              P       ++TP   +    +    T   A+S +N+ ++   VT+  VT    AS   
Sbjct: 1496 PTPAEGTSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSP 1555

Query: 2754 TATTGTVTMAGAV---IAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNT 2810
            T   GT            P T          +S  +  S   ID +     S       T
Sbjct: 1556 TTADGTSMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTT 1615

Query: 2811 SEGVVLLSYSGQKTEGPQRISAKISQIPPAS--AMDIEFQQSVSKSQVKPDSVTASQP-P 2867
            +EG   ++ S      P   S  +S  P AS  A  +      S S V   +  +S P P
Sbjct: 1616 AEG-SSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTP 1674

Query: 2868 SKGPQAPAG-YANVATHSTLVL---------------TAQTYNASPVISSVKADRPSLEK 2911
            ++G   P   Y    T  T +                T    N++PV +S +A R S   
Sbjct: 1675 AEGTSMPTSTYTEGRTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEA-RSSPTT 1733

Query: 2912 PEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETK 2971
             E   +  STP    GT  + +  ++T PVL      L+ + + T    + PVT   E  
Sbjct: 1734 SEGTSMPNSTP--SEGTTPLTSIPVSTTPVLSSEASTLSATPIDT----STPVTTSTEAT 1787

Query: 2972 VLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGP 3031
                   G+++    P +  S+  T +   P   ++ A+   S L+   +D++SP  +  
Sbjct: 1788 SSPTTAEGTSI----PTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTST 1843

Query: 3032 GPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISS----IHPEQSVIMPP------ 3081
              SS P  +  +S A++  S  +T + +  +      SS    +    +V   P      
Sbjct: 1844 AVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQ 1903

Query: 3082 -HSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEA----------LHSPRAPLQPQQIE 3130
              S   T   S +     R   P L SI  S    A          L   R P+      
Sbjct: 1904 VSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQA 1963

Query: 3131 VRAPQRA-STPQPAPA---GVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRL 3186
              +P  A  T  P PA   G   L S       V        +T PV +      S    
Sbjct: 1964 SSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGS 2023

Query: 3187 HPYTVPRDVRIMV---HPHVTAVSEQPRAADGVVK--------VPPASKAPQQPGKEAAK 3235
               T      I         T ++  P +   VV          P  SK       EA+ 
Sbjct: 2024 SSPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASS 2083

Query: 3236 TPDAKAAPTPTPAP---VPVPVPLP-APAPAPHGEARILTVTPSNQLQGLPLTPPVVVTH 3291
            +  A+ +     AP    P+   +P +  P    EA  L+ TP +         PV+ + 
Sbjct: 2084 SATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDS------NSPVITST 2137

Query: 3292 GVQI--VHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGE 3349
             V    + + G   Q   Y D RT         T  P +++V   S   T +  P     
Sbjct: 2138 EVSSSPIPTEGTSMQTSTYSDRRT-------PLTSMPVSTTVVASSAISTLSTTPVDTST 2190

Query: 3350 PLQPPQPVQSTQPAQPAPPCPPSQLGQPGQP----PSSKMPQVSQEA---KGTQTGVEQP 3402
            P+      +S+         P S   +   P    P S MP V+ EA     T      P
Sbjct: 2191 PVTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTP 2250

Query: 3403 RLPAGPANRPP--EPHTQVQRAQAETGPTSFPS-PVSVSMKPDLPVS-LPTQTAPKQPLF 3458
               +  A   P     T +  +    G T   S PVS ++  +  VS L T        F
Sbjct: 2251 VTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPF 2310

Query: 3459 VPTTSGPSTPP 3469
              +T   S PP
Sbjct: 2311 TTSTEASSPPP 2321



 Score =  125 bits (314), Expect = 8e-28
 Identities = 424/2058 (20%), Positives = 683/2058 (33%), Gaps = 306/2058 (14%)

Query: 1565 TSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKD-------QKPKEVEKQEDTENHP 1617
            TSEG +  T +  E    F S  M ++ M     E              V    +  + P
Sbjct: 2204 TSEGTSMPTSTPSEGSTPFTS--MPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSP 2261

Query: 1618 KTPE--SAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVE 1675
             T E  S P +  SE  TP +  P S T+V   S  S L  T  D               
Sbjct: 2262 TTAEGTSIPTSTLSEGTTPLTSIPVSHTLVA-NSEVSTLSTTPVDSNT------------ 2308

Query: 1676 PATVSEEAK---PASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLD 1732
            P T S EA    P +E    P     + + P    P   +  M A  E  +    P    
Sbjct: 2309 PFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMP--VSTTMVASFETSTLSTTP---- 2362

Query: 1733 AKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAE 1792
            A   TP  ++SQA S+    P +    S P     E + P    P +T          +E
Sbjct: 2363 ADTSTPVTTYSQAGSS----PTTADDTSMPTSTYSEGSTPLTSVPVSTMPV-----VSSE 2413

Query: 1793 AAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKL 1852
            A+  S  P    ++   PV         ++ S +P  A   SI   P +  +  +    +
Sbjct: 2414 ASTHSTTP----VDTSTPVT------TSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPV 2463

Query: 1853 KRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMG 1912
              +     EA  L    ++      T+++ S++     +  +P+S     +       + 
Sbjct: 2464 STTPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVS 2523

Query: 1913 DHENRSPVKE-----PVE--QPRVTRKRLEREL--QEAAAVPT-------TPRRGRPPKT 1956
                 SP        PV+   P VT   +       E  ++PT       TP R  P  T
Sbjct: 2524 TTPVASPEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVST 2583

Query: 1957 RRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTE 2016
            +  A  E    +  P +T         P +  T     P   K  + P   +T  E +T 
Sbjct: 2584 KPLASSEASTLSTTPVDT-------SIPVTTSTETSSSPTTAKDTSMP--ISTPSEVSTS 2634

Query: 2017 VGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSK 2076
            +     +  S+M   ++E    S    D +   T      ++P               + 
Sbjct: 2635 L---TSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPT--------------TA 2677

Query: 2077 RGRSRNSRLAVDKSASLKNVDA-----AVSPRGAAAQAGERESGVVAVSPEKSESPQKED 2131
             G S  +    ++S  L N+       A S     +      S  V  S E S SP   +
Sbjct: 2678 EGSSMPTSTPGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAE 2737

Query: 2132 GLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYK 2191
            G S ++ S P D         VS    +           ++ ++        +S+    +
Sbjct: 2738 GTSMRI-STPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAE 2796

Query: 2192 ADAPEGLAPEDRDKP--AHQASETELAAAIGSIIN--------------DISGEP---EN 2232
              +     P +   P  +   + T +A++    ++                S  P   E 
Sbjct: 2797 VTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSSPTTAEG 2856

Query: 2233 FPAPPPYPGESQTDLQP-PAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDP 2291
               P     E  T L   P     +  SE    +   V   +    +TE S  P  A   
Sbjct: 2857 IVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGT 2916

Query: 2292 SAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRK------RNTN 2345
            S   +   E     +    S     GS+   ++    D     TT +           T+
Sbjct: 2917 SMPISTPSEVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTS 2976

Query: 2346 KKVVAPVESHVPESNQAQGESPAANE----------------GTTVQHPEAPQEEKQSEK 2389
              +  P E   P ++ +    P A+                  T+ +   +P   + +  
Sbjct: 2977 MPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGI 3036

Query: 2390 PHSTPPQSCTSDLSKIP--STENSSQEISVEERTPTKASVP----PDLPPPPQPAPVDEE 2443
            P STP +  T  L+ IP  +T  +  E S    TP  ++ P     ++   P PA     
Sbjct: 3037 PISTPSEGST-PLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSM 3095

Query: 2444 PQARFRVHSI-IESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWI 2502
            P + +   S  +   PV+     S  I TL S T    S PV +    H SP T     +
Sbjct: 3096 PISTYSEGSTPLTGVPVSTTPVTSSAISTL-STTPVDTSTPVTTSTEAHSSPTTSEGTSM 3154

Query: 2503 TRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTA----- 2557
                 P   STP   +P  T    V +  STL    +D      TS  +TS TTA     
Sbjct: 3155 P-TSTPSEGSTPLTYMPVSTMLV-VSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSI 3212

Query: 2558 ------------IAEPVSAAPCLHE----APPPPVDSKKPL----EEKTAPPVTNNSEIQ 2597
                         + PVS  P            PVDS  PL    E  ++PP    + + 
Sbjct: 3213 PTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMP 3272

Query: 2598 ASEVLVAADKEKVAPV----IAPKITSVISRMPVSIDLENSQKITL---AKPAPQTLTGL 2650
             S     +      PV    +A   TS +S  P     + S  +T    A  +P    G 
Sbjct: 3273 TSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPA----DTSTPVTTYSQASSSPPIADG- 3327

Query: 2651 VSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTP 2710
             S  T   +    P+  +       V++  S +ST   PV+    PV   T      TT 
Sbjct: 3328 TSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTT--PVDT-STPVTTSTEASLSPTTA 3384

Query: 2711 VNATVGTVNAAPGTVNAAASAVNAT-ASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAP 2769
               ++ T + + GT   A+  V+ T   +  V   + T        TT T   +   IA 
Sbjct: 3385 EGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAE 3444

Query: 2770 STKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQR 2829
             T      ++  ++   P S+  +   P  +   + L     +    ++ S      P  
Sbjct: 3445 GTSLPTSTTSEGST---PLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNSSP-- 3499

Query: 2830 ISAKISQIP--------------PASAMDIEFQQSVSKSQVKPDS---VTASQPPSKGP- 2871
             +A+++ +P              P S   +   ++ + S    DS   VT+S   S  P 
Sbjct: 3500 TTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPA 3559

Query: 2872 --QAPAGYANVATHSTLVLTAQTYNASPVISSVKA--DRPSLEKPEPIHLSV---STPVT 2924
              Q      +  +  +  LT    +++ V SS  +    PS+++  P+  S    STP  
Sbjct: 3560 TLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTP 3619

Query: 2925 QGGTVKVLTQGINTP-----PVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLG 2979
                 +V+T  ++TP     P+ +    V T S+  +    A  + +   T V+    + 
Sbjct: 3620 P----EVITLPMSTPSEVSTPLTI--MPVSTTSVTISEAGTASTLPVDTSTPVITSTQVS 3673

Query: 2980 STLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRA 3039
            S+        +P   P+E +   +   +   R  S    + L   S   S P  +S    
Sbjct: 3674 SSPVTPEGTTMPIWTPSEGSTPLTTMPVSTTRVTSS-EGSTLSTPSVVTSTPVTTSTEAI 3732

Query: 3040 SHPSSTASTA--------LSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLS 3091
            S  ++  ST         +ST  T +L +  PV +F     PE S    P S+  ++S++
Sbjct: 3733 SSSATLDSTTMSVSMPMEISTLGTTILVSTTPVTRF-----PESSTPSIP-SVYTSMSMT 3786

Query: 3092 HLSQGE----VRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRAST--PQPAPA 3145
              S+G         T T+P  T S R   L      +    I V +P  AST    P   
Sbjct: 3787 TASEGSSSPTTLEGTTTMPMSTTSERSTLL----TTVLISPISVMSPSEASTLSTPPGDT 3842

Query: 3146 GVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTA 3205
              P L S     +   + +P    T      + +  +  R  P T      ++V    T 
Sbjct: 3843 STPLLTS----TKAGSFSIPAEVTT------IRISITSERSTPLTT-----LLV--STTL 3885

Query: 3206 VSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPT-PAPVPVPVPLPAPAPAPH 3264
             +  P A+  +   PP   +          TP    A TPT P    + V +      P 
Sbjct: 3886 PTSFPGAS--IASTPPLDTS-------TTFTPSTDTASTPTIPVATTISVSVITEGSTP- 3935

Query: 3265 GEARILTVTP--SNQLQGLPLTPPVVVTHGVQIVH----SSGELFQEYRYGDIRTYHPPA 3318
            G    +  TP  S+     P T   V T  +        S+        +   + +  PA
Sbjct: 3936 GTTIFIPSTPVTSSTADVFPATTGAVSTPVITSTELNTPSTSSSSTTTSFSTTKEFTTPA 3995

Query: 3319 QLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPG 3378
              T       +    PS  +T ++G       L       ++      P  P S+  +P 
Sbjct: 3996 MTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTSTSVTTRPVTPSSESSRPS 4055

Query: 3379 QPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEP-HTQVQRAQAETGPTSFPS---- 3433
               S  +P     A  +      P   A      PE   T   R +  T  TSFP+    
Sbjct: 4056 TITSHTIPPTFPPAHSS----TPPTTSASSTTVNPEAVTTMTTRTKPSTRTTSFPTVTTT 4111

Query: 3434 --PVSVSMKPDLPVSLPT 3449
              P + ++K + P S PT
Sbjct: 4112 AVPTNTTIKSN-PTSTPT 4128



 Score =  115 bits (289), Expect = 6e-25
 Identities = 411/2045 (20%), Positives = 667/2045 (32%), Gaps = 272/2045 (13%)

Query: 1631 LKTPPSVGPPSVTVVTLESAPSALE---KTTGDKTVEAPLVTEEKTVEPATVSEEAKPAS 1687
            L T P      VT  T  S+ +  E    T    +  +PL+T   ++  +T    +  AS
Sbjct: 1593 LSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLT---SIPVSTTPVASPEAS 1649

Query: 1688 EPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPP--------TPG 1739
              +  PV+     + P     +  ++  PA   EG+S     Y + + P        TP 
Sbjct: 1650 TLSTTPVDS----NSPVITSTEVSSSPTPA---EGTSMPTSTYTEGRTPLTSITVRTTPV 1702

Query: 1740 ASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQP 1799
            AS + +  +  P  +ST   +    +S          P++T     +      + P S  
Sbjct: 1703 ASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPS---EGTTPLTSIPVSTT 1759

Query: 1800 P--ASEDLEVDP-PVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSN 1856
            P  +SE   +   P+         ++ + +P  A   SI    ++     +    +  + 
Sbjct: 1760 PVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTL 1819

Query: 1857 SPRGEAQKLLELKMEAEK--ITRTASKNSAADLEHPE-----PSLPLSRTRRRNVRSVYA 1909
                EA  L    +++    +T TA  +S    E        PS   +      V +   
Sbjct: 1820 VANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTV 1879

Query: 1910 TMGDHENRSPVKEPVEQPRVTRKRLERE--LQEAAAVPT-TPRRGRPP------KTRRRA 1960
               +    S        P  T  ++       + +++PT TPR GRPP       T   A
Sbjct: 1880 ASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVA 1939

Query: 1961 DEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATR-PEATT---- 2015
              E    +   A+T  P   +    S  T A G        +E     T  P +TT    
Sbjct: 1940 SSEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVS 1999

Query: 2016 -EVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPE-TAPVEVVEKKP----AP 2069
             E          +  P     E  S        +     P E T P+  +        + 
Sbjct: 2000 SEASTLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSS 2059

Query: 2070 EKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQK 2129
            E N+ S       +++     AS        S   +A   G      + +S     SP+ 
Sbjct: 2060 EGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPE- 2118

Query: 2130 EDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAA 2189
                +S L + PVD +         +S P P      +          +  +  ++   A
Sbjct: 2119 ----ASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVA 2174

Query: 2190 YKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAP---------PPYP 2240
              A +     P D   P   ++E   +       +  +  P     P         P   
Sbjct: 2175 SSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVT 2234

Query: 2241 GESQTDLQPPAGAQA-LQPSEEGMETDEAVSGI-LETEAATESSRPPVNAPDP------- 2291
             E+ T    P      +  S E   +     G  + T   +E + P  + P         
Sbjct: 2235 SEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANS 2294

Query: 2292 -----SAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNK 2346
                 S  P D+      S+E S   P A+G+     T     +G    TR       + 
Sbjct: 2295 EVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMPTST---SSEGNTPLTRMP----VST 2347

Query: 2347 KVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIP 2406
             +VA  E+    +  A   +P     T  Q   +P     +  P ST  +  T  L+ +P
Sbjct: 2348 TMVASFETSTLSTTPADTSTPVT---TYSQAGSSPTTADDTSMPTSTYSEGSTP-LTSVP 2403

Query: 2407 STENS--SQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSD 2464
             +     S E S    TP   S P         +P   E            S P +PPS+
Sbjct: 2404 VSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGT----------SIPTSPPSE 2453

Query: 2465 PSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKA 2524
             + P+ ++P  T   +S   +  G    +P    T   T  E   + +T    + P + A
Sbjct: 2454 GTTPLASMPVSTTPVVS---SEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTA 2510

Query: 2525 SDVDT---------------SSSTLRKILMDPKYV---------SATSVTSTSVTTAI-- 2558
            S+  T                +STL    +D             SATS   TS+ T+   
Sbjct: 2511 SEGSTLLTSIPVSTTPVASPEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYS 2570

Query: 2559 -------AEPVSAAPCLHEAPPP----PVDSKKPLE------------EKTAPPVTNNSE 2595
                   + PVS  P            PVD+  P+             + T+ P++  SE
Sbjct: 2571 EGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSE 2630

Query: 2596 IQASEVLVAADKEKVAPVIAPKI--TSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSA 2653
            +  S   +      VA   A  +  T V +R  V+     S   T A+ +    +     
Sbjct: 2631 VSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGER 2690

Query: 2654 LTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNA 2713
             T L N+ LV    L      +++T     STP               G    ++TP + 
Sbjct: 2691 STPLTNI-LVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDG 2749

Query: 2714 TVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKC 2773
            +    +    T+  A+S  +  ++    T+  VT ++   ++ T     +     PS   
Sbjct: 2750 STPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETS 2809

Query: 2774 KQRASANEN----SRFHPGSM---PVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEG 2826
                S   N    +    G++   PV    P    + A     T+EG+V+   +   +EG
Sbjct: 2810 TPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTA--SEG 2867

Query: 2827 PQRI-SAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYA------- 2878
               + S  +S  P AS+       +   + +    VT S   S  P    G +       
Sbjct: 2868 STLLTSIPVSTTPVASSEASTLSTTPVDTSIP---VTTSTEGSSSPTTAEGTSMPISTPS 2924

Query: 2879 NVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVT--QGGTVKVLTQGI 2936
             V+T  T +L +    A    S++         P       S+  T  +G ++ + T G 
Sbjct: 2925 EVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGE 2984

Query: 2937 NTPPVL---VHNQLVLTPSIVTTNKKLAD---PVTLKIETKVLQPANLGSTLTPHHPPAL 2990
               P+    V    V +    T ++  AD   PVT   E         G+ +    P + 
Sbjct: 2985 RRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGI----PIST 3040

Query: 2991 PSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTAL 3050
            PS+  T +  +P   +  A    S L+   +D++SP  +    SS P  +  +S   +  
Sbjct: 3041 PSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTY 3100

Query: 3051 STNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITY 3110
            S  +T +   G+PV     S  P  S            ++S LS   V  +TP   S   
Sbjct: 3101 SEGSTPL--TGVPV-----STTPVTS-----------SAISTLSTTPVDTSTPVTTS--- 3139

Query: 3111 SIRPEALHSPRAPLQPQQIEVRAPQRASTPQP-APAGVPALASQHPPEEEVHYHLPVARA 3169
                   HS     +   +    P   STP    P     + S    E+      PV  +
Sbjct: 3140 ----TEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSS---EDSTLSATPVDTS 3192

Query: 3170 TAPVQSEVLVMQS---EYRLHPYTVPRDVRIMVHPHVTAVSEQPRA---ADGVVKVPPAS 3223
            T PV +      S   E    P + P +   M       VS  P A   A  +   P  S
Sbjct: 3193 T-PVTTSTEATSSTTAEGTSIPTSTPSEG--MTPLTSVPVSNTPVASSEASILSTTPVDS 3249

Query: 3224 KAPQQPGKEAAKTP---DAKAAPTPTPAPVPVPV-PLP-APAPAPHGEARILTVTPSNQL 3278
              P     EA+ +P   +  + PT TP+    P+  +P +       E   L+ TP++  
Sbjct: 3250 NTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPAD-- 3307

Query: 3279 QGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASS-------- 3330
               P+T     +    I   +      Y  G      P   ++ +  P  SS        
Sbjct: 3308 TSTPVTTYSQASSSPPIADGTSMPTSTYSEGST----PLTNMSFSTTPVVSSEASTLSTT 3363

Query: 3331 ---VGLPSRTKTAAQGPP--PEGEPLQPPQPVQSTQPAQPAP----PCPPSQLGQPGQPP 3381
                  P  T T A   P   EG  +    P + T P    P    P   S++      P
Sbjct: 3364 PVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTP 3423

Query: 3382 --SSKMPQVSQEAKGTQTGVEQPRLPAG-------PANRPPEPHTQVQRAQAETGPTSFP 3432
              S+ +   S EA  + T  E   LP         P +  P   T V  ++A T  T+ P
Sbjct: 3424 VDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTLSTT-P 3482

Query: 3433 SPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTS 3492
               S  +    P +    TA    +   T    STP    L +      P   S     S
Sbjct: 3483 VDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTP----LTNMPVSTTPVASSEASTLS 3538

Query: 3493 QRPVD 3497
              PVD
Sbjct: 3539 TTPVD 3543



 Score =  114 bits (285), Expect = 2e-24
 Identities = 401/1943 (20%), Positives = 621/1943 (31%), Gaps = 316/1943 (16%)

Query: 1649 SAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADP 1708
            SA +    TT    VE  +     T    T  E +  +  P  +                
Sbjct: 63   SAANTATGTTSTNVVEPRMYLSCSTNPEMTSIESSVTSDTPGVSSTRMTPTESRTTSEST 122

Query: 1709 DKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGA-SFSQAESNVDPEP-------------- 1753
                 + P+  E+ SS   P   D    TP   S S   + V   P              
Sbjct: 123  SDSTTLFPSSTEDTSSPTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSFEAYTSLTYKV 182

Query: 1754 DSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEV-DPPVA 1812
            D + PL+   Q S     P++     + ++E      +  A   +  +SE + +   PV 
Sbjct: 183  DMSTPLTTSTQASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVE 242

Query: 1813 AKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKL------- 1865
                    ++ S +P  A   S+     +  S  + R  L        EA  L       
Sbjct: 243  ISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAAT 302

Query: 1866 ---LELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVK- 1921
               +    EA     TA   S     + E S PL+ T    +    + M    + +PV  
Sbjct: 303  NIPVITSTEASSSPTTAEGTSIPTSTYTEGSTPLTSTPASTMPVATSEMSTL-SITPVDT 361

Query: 1922 --------EPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAE 1973
                    EP   P  T       L    +  +TP    P  T   A  E    +  P +
Sbjct: 362  STLVTTSTEPSSLP--TTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVD 419

Query: 1974 TLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAA 2033
                     S     TA+         ++     +T  E +T +        +SM P + 
Sbjct: 420  ---------SKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPL--------TSM-PVST 461

Query: 2034 EEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASL 2093
               A SE   +      D     T   E     P  E NS      S  S      S S 
Sbjct: 462  TPVASSEAS-NLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVST 520

Query: 2094 KNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDV 2153
              V ++             E+  ++ +P  + +P      +S   + P       E   +
Sbjct: 521  MPVASS-------------EASTLSTTPVDTSTPVTTSSEASSSSTTP-------EGTSI 560

Query: 2154 SASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADA-----------PEGLAPED 2202
              S PS  +T L       + V      +EAS ++   AD+                 E 
Sbjct: 561  PTSTPSEGSTPLTNMPVSTRLVVS----SEASTTSTTPADSNTFVTTSSEASSSSTTAEG 616

Query: 2203 RDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEG 2262
               P    SE        S+   +    E        P +S T +     A +   + EG
Sbjct: 617  TSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTT-PVDSNTPVTTSTEATSSSTTAEG 675

Query: 2263 METDEAVSGILETEAATESSRPPVN--------APDPSAGPTDTKEARGNSSETSHSVPE 2314
                 +      TE +T  +  PVN        A   S  P DT      S+E S S   
Sbjct: 676  TSMPTSTY----TEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTT 731

Query: 2315 AKG-----SKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAA 2369
            A G     S   E +         KT  +  + +T         +H+  S +A   SP  
Sbjct: 732  ADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASC-SPTT 790

Query: 2370 NEGTT--VQHPEAPQEEKQSEKPHSTPPQSC-TSDLSKIPSTENSSQEISVE---ERTPT 2423
             EGT+  +  P        S     TP  S   S LS  P   NS    S E     TP 
Sbjct: 791  TEGTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPA 850

Query: 2424 KASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPP 2483
            + +  P         P+   P +   V +   S   T P D S P+    + T A+ SP 
Sbjct: 851  EGTSMPTSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVT---NSTEARSSPT 907

Query: 2484 VASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKY 2543
             + G     S P + +  +T   +       S A        D  T  +T  +    P  
Sbjct: 908  TSEGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTT 967

Query: 2544 VSATSVTSTSVTTAIAEPVSAAPCLHEA---------PPPPVDSKKPL----EEKTAPPV 2590
               TS+  TS  +    P+++ P  H              PVDS  PL    E  + PP 
Sbjct: 968  AEGTSIP-TSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPT 1026

Query: 2591 TNNSEIQASEVLVAADKEKVAPV----IAPKITSVISRMPVSIDLENSQKITLAKPAPQT 2646
               + +  S     +      PV    +A   TS +S  P     + S  +T    A  +
Sbjct: 1027 AEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPA----DTSTPVTTYSQASSS 1082

Query: 2647 LTGL--VSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPV 2704
             T     S  T   +    P+ ++    +  V++  S +ST     ++   PV   T   
Sbjct: 1083 STTADGTSMPTSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSI---PVTTSTEAS 1139

Query: 2705 NVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAG 2764
            +  TT    ++ T   + GT   A+  V+ T   + V++ A T ++  V + T   T   
Sbjct: 1140 SSPTTAEGTSIPTSPPSEGTTPLASMPVSTT---LVVSSEANTLSTTPVDSKTQVATSTE 1196

Query: 2765 AVIAPST-KCKQRASANENSRFHP-GSMPV------------IDDRPADAGSGAGLRVNT 2810
            A   P T +     ++    R  P  SMPV            +   P D  +       T
Sbjct: 1197 ASSPPPTAEVTSMPTSTPGERSTPLTSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAET 1256

Query: 2811 SEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQ--------VKPDSVT 2862
            S        +   T      S  ++ IP ++ +    + S   +         V  + V+
Sbjct: 1257 SSSPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVS 1316

Query: 2863 ASQPPSKGPQAPAG--------YANVATHSTLVL--------TAQTYNASPVISSVKADR 2906
            +S  P++G   P            ++  ++TLV         T    N++PV +S +A  
Sbjct: 1317 SSPTPAEGTSMPTSTYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEACS 1376

Query: 2907 PSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTL 2966
             S    E   +  S P    GT  + +  ++T PV+      L+ + V T+     P T 
Sbjct: 1377 -SPTTSEGTSMPNSNP--SEGTTPLTSIPVSTTPVVSSEASTLSATPVDTST----PGTT 1429

Query: 2967 KIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSP 3026
              E         G ++    P + PS+  T +  +P   +  A+   S L+   +D++SP
Sbjct: 1430 SAEATSSPTTAEGISI----PTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSP 1485

Query: 3027 RPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQ 3086
              +    SS P  +  +S A +  S  +T +    IPV                    T 
Sbjct: 1486 VVTSTAVSSSPTPAEGTSIAISTPSEGSTAL--TSIPVS-------------------TT 1524

Query: 3087 TVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAG 3146
            TV+ S ++         + P  TYS                       Q +S+P  A  G
Sbjct: 1525 TVASSEINSLSTTPAVTSTPVTTYS-----------------------QASSSPTTAD-G 1560

Query: 3147 VPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAV 3206
                 S +         LPV        S +LV+ SE      T P D +      VTA 
Sbjct: 1561 TSMQTSTYSEGSTPLTSLPV--------STMLVVSSEANTLS-TTPIDSK----TQVTAS 1607

Query: 3207 SEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGE 3266
            +E             AS +    G     +  ++ +P  T  PV       +  P    E
Sbjct: 1608 TE-------------ASSSTTAEGSSMTISTPSEGSPLLTSIPV-------STTPVASPE 1647

Query: 3267 ARILTVTPSNQLQGLPLTPPVVVTHGVQI--VHSSGELFQEYRYGDIRTYHPPAQLTHTQ 3324
            A  L+ TP +         PV+ +  V      + G       Y + RT  P   +T   
Sbjct: 1648 ASTLSTTPVDS------NSPVITSTEVSSSPTPAEGTSMPTSTYTEGRT--PLTSITVRT 1699

Query: 3325 FPAASSV-----------GLPSRTKTAAQGPP--PEGEPLQPPQPVQSTQPAQPAP---- 3367
             P ASS              P  T T A+  P   EG  +    P + T P    P    
Sbjct: 1700 TPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTT 1759

Query: 3368 PCPPSQLGQPGQPP--SSKMPQVSQEAKGTQTGVEQPRLPAG-------PANRPPEPHTQ 3418
            P   S+       P  +S     S EA  + T  E   +P         P    P  HT 
Sbjct: 1760 PVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTL 1819

Query: 3419 VQRAQA---ETGPTSFPSPVSVS 3438
            V  ++A    T P    SPV  S
Sbjct: 1820 VANSEASTLSTTPVDSNSPVVTS 1842



 Score = 33.5 bits (75), Expect = 4.0
 Identities = 27/110 (24%), Positives = 51/110 (46%), Gaps = 1/110 (0%)

Query: 242  SRSPHSSQSRNQSPQRLASQASRPTRSPS-GSGSRSRSSSSDSISSSSSTSSDSSDSSSS 300
            S +P ++ +   SP   A   S PT +PS GS   +R   S ++ +SS TS+ S+  + +
Sbjct: 1010 SNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADT 1069

Query: 301  SSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTS 350
            S+  +      S++  A  + + +S   +       + V    V S++ S
Sbjct: 1070 STPVTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSVPVSTRLVVSSEAS 1119



 Score = 32.7 bits (73), Expect = 6.8
 Identities = 25/112 (22%), Positives = 52/112 (46%), Gaps = 4/112 (3%)

Query: 242  SRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSS 301
            +R+P ++ +   S    A   S P  +P   G R    +S S+S+    SS++S  S + 
Sbjct: 2955 TRTPVTTSAEASSSPTTAEGTSMPISTP---GERRTPLTSMSVSTMPVASSEASTLSRTP 3011

Query: 302  SDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKD 353
            +D S   +  + A  +PT+   + +    P +     + ++PV +T  ++ +
Sbjct: 3012 ADTSTPVTTSTEASSSPTTAEGTGIPISTPSEG-STPLTSIPVSTTPVAIPE 3062


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  134 bits (338), Expect = 1e-30
 Identities = 337/1499 (22%), Positives = 501/1499 (33%), Gaps = 268/1499 (17%)

Query: 2050 TDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASL-KNVDAAVSPRGAAAQ 2108
            T K  P   P+  V+  P   KNS S +  S +  + +   A+L K       P G  A 
Sbjct: 552  TTKKDPTVLPL--VQAAP---KNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPAS 606

Query: 2109 AGERESGV-VAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAK 2167
            +     GV  + S  K++S    D     LKS  + P        + ++ P+  A   AK
Sbjct: 607  SMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFP--LESADPAGVAPTTAK 664

Query: 2168 QMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIIN-DI 2226
                          +  + +A+   +    LAP++   P  + + T L     +  N  +
Sbjct: 665  GT------------STYTTTASPFLEGTVSLAPKNH--PVKEGTLTTLPLVPTASENCPV 710

Query: 2227 SGEPENFPAP-------PPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAAT 2279
            +  P+N  AP       P  P    +   PPAG              + V GI  T A  
Sbjct: 711  APSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPP---------GTKKVDGISHTSALA 761

Query: 2280 ESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSR 2339
              +  P   P   +G + T  ++G  +  + S P   G   V V+   K    +K +   
Sbjct: 762  PVASSPKECPTEDSGASATASSKGTLTYLADS-PSPLG---VSVSPQTKRPPTKKGSAGP 817

Query: 2340 RKRNTN-KKVVAPVE-SHVPESN---QAQGESPAANEGTTVQHPEA--------PQEEKQ 2386
                 N    V+PVE S +PE++   Q   +SPA     T   P+         P   K 
Sbjct: 818  DTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKG 877

Query: 2387 SEKPHSTPPQSCTSDL---SKIPSTENSSQE--ISVEERTPTKASVPP---DLPPPPQPA 2438
               P    P     +L    + P+T    Q   +S+   +P KA   P    +P  P P 
Sbjct: 878  VTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPK 937

Query: 2439 PVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKV 2498
                 P A           P +P   P+ P P          +PP A+   P   P T  
Sbjct: 938  GAPTPPAAT----------PPSPKGGPATPSPKWAP------TPPAATPPSPKGGPATP- 980

Query: 2499 TEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAI 2558
                     P+   TP  A PP  K      S     K    P  V+  S   +   T  
Sbjct: 981  --------SPKGAPTPPAATPPSPKGGPATPSP----KGAPTPPAVTPPSPKGSPAATPF 1028

Query: 2559 AEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKI 2618
             +  S  P     PP P  S          P T  + + + +   A    K AP   P  
Sbjct: 1029 PKGASTPPAA--TPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPT-PPAA 1085

Query: 2619 TSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTT 2678
            T    +   +        +  A   P    GL +                  P KG+ TT
Sbjct: 1086 TPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATP-----------------PHKGAPTT 1128

Query: 2679 LKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASA 2738
                 +TP  P   L  P      P    TTP  AT  +      T     +     A+ 
Sbjct: 1129 P---AATPPSPKGGLATPP-----PKGAPTTPA-ATPPSPKGGLATPPPKGAPTTPAATP 1179

Query: 2739 VTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPA 2798
             +   G  T +  G   T        A   PS K      + + +   P + P     P+
Sbjct: 1180 PSPKGGLATPSPKGAPTTP-------AATPPSPKGGLATPSPKGAPTTPAATP-----PS 1227

Query: 2799 DAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKP 2858
              G                   G  T  P+      +  PP+                 P
Sbjct: 1228 PKG-------------------GLATPSPKGAPTTPAATPPS-----------------P 1251

Query: 2859 DSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLS 2918
                A+ PP   P  PA                     P +    A  P    P P    
Sbjct: 1252 KGGPATPPPKGAPTPPAA------------------TPPSLKGGLATPPHKGAPNPA--V 1291

Query: 2919 VSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANL 2978
            V+ P  +GG      +G  TPP         TP     +     P        V  P+  
Sbjct: 1292 VTPPSPKGGPATSPPKGAPTPPAA-------TPPSPKGSPGTPPPKGAPTPPAVTPPSPK 1344

Query: 2979 GSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPR--PSGPGPSSF 3036
            G+   P   P+  SK          GP+ PA  T SH     +   SP+  P+ P P   
Sbjct: 1345 GTPTLPATTPS--SKGGPTTPSSKEGPTPPA-ATPSHKGGPAMTPPSPKRGPAIPSPKGD 1401

Query: 3037 PRAS-----HPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLS 3091
            P +       P    +T ++       + G   P  ++ +  +++   P  S  +    +
Sbjct: 1402 PTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKA---PATSAPKGGPAT 1458

Query: 3092 HLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALA 3151
              S+G+     PTLP++T         SP+ P  P+Q+   +  + +   PAP G P L 
Sbjct: 1459 PSSKGD-----PTLPAVTPP-------SPKEPPAPKQVATSSSPKKAPATPAPMGAPTLP 1506

Query: 3152 SQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTV-PRDVRIMVHPHVTAVSEQP 3210
            +  P   +     P +R      +  L+ +      P T+ P++   ++ P +T  S + 
Sbjct: 1507 AVIPSSPKEVPATPSSRRDPIAPTATLLSKKT----PATLAPKEA--LIPPAMTVPSPKK 1560

Query: 3211 RAADGVVKVPPASKAPQQPGKEAAKTPDA-KAAPTPTPAPVPVPVPLPAPAPAPHGEARI 3269
              A    K  PA+ + ++     A TP   K AP+P    +P  V  P+P  AP   A  
Sbjct: 1561 TPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPA-- 1618

Query: 3270 LTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLT---HTQFP 3326
              VTP +  +G P TP    T     V  S          D  T   PA +T       P
Sbjct: 1619 --VTPPSPEKG-PATPAPKGTPTSPPVTPSS-------LKDSPT--SPASVTCKMGATVP 1666

Query: 3327 AASSVGLPSRT-----KTAAQGPPPEGEPL------QPPQPVQSTQPAQPAPPCPPSQLG 3375
             AS  GLP++      K     P PE  P+      + PQ  +S+  + P  P P ++ G
Sbjct: 1667 QASK-GLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNG 1725

Query: 3376 QPGQ----PPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSF 3431
              G      P+  +P V +++  T  G +    P GP   P    +    A A       
Sbjct: 1726 SKGPLSTVAPAPLLP-VQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPK 1784

Query: 3432 PSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVL--PHTEFQPAPKQDSSP 3488
            P   SVS  P  PVSLP   +P  P   P      + PGLVL  P     PA + +  P
Sbjct: 1785 PESASVSAAPSPPVSLPLAPSP-VPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLP 1842



 Score =  118 bits (295), Expect = 1e-25
 Identities = 293/1279 (22%), Positives = 441/1279 (34%), Gaps = 254/1279 (19%)

Query: 2400 SDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQAR-FRVHSIIESDP 2458
            ++ + +P +   S   ++ +  PT   +PP   P PQ  P+    QA  F   S I S P
Sbjct: 21   AETAVLPMSSALSVTAALGQPGPT---LPPPCSPAPQQCPLSAANQASPFPSPSTIASTP 77

Query: 2459 VTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPAL 2518
            +       +P P   S TA  L      G  P    PT +   I     P A +  SP +
Sbjct: 78   L------EVPFPQSSSGTALPL------GTAPEA--PTFLPNLIGPPISPAALALASPMI 123

Query: 2519 PPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTA---IAEPVSAAPCLHEAPPPP 2575
             P  K +   +SS+ L  + + P  V  +S    ++ T+   +A   S +     AP  P
Sbjct: 124  APTLKGTP--SSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAP 181

Query: 2576 VDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQ 2635
             + K  L +  +  V N     +   +V+         +A  I S ++ +P     + + 
Sbjct: 182  SEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMA-SIQSGVASLP-----QTTP 235

Query: 2636 KITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTP--------A 2687
              TLA  +PQ     +S++  L++       +LKGPV        S  S P        A
Sbjct: 236  TTTLAIASPQVKDTTISSV--LISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTA 293

Query: 2688 GPVNVLKGPVNV-------------------LTGPVNVLTTPVNATVGTVNAAPGT---- 2724
            GP      P+++                    TGP + L+ P   T+   +++ G     
Sbjct: 294  GPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGP-SALSDPTVKTISVDHSSTGASYPS 352

Query: 2725 -------VNAAASAVNATASAVTVTAGAVTAASGGVTATT----GTVTMAGAV-IAPSTK 2772
                   + +    V AT +A  V A +V      +++ T    G++ +A +  ++P+T 
Sbjct: 353  QRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTS 412

Query: 2773 CKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVN---TSEGVVLLSYSGQKTEGPQR 2829
               ++S N    +     P++   P  +     L V    T       ++       P  
Sbjct: 413  LILKSSPNATYHY-----PLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPM 467

Query: 2830 ISAKISQIPPASAMDIEFQQSVSK---SQVK--------------------PDSVTASQP 2866
             S  IS I P S   +       K   +QV                     P SV    P
Sbjct: 468  SSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFP 527

Query: 2867 PSKGPQ-------------APAGYANVATHSTLVLTAQTYNASPVISSVKAD-------- 2905
              K  Q             A AG       + L L       SP   S  +         
Sbjct: 528  TQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPE 587

Query: 2906 ----RPSLEKPEPIHL---SVSTPVTQGGTVKVLTQ----GINTPPVLVHNQLVLTPSIV 2954
                + SL +P PI     S+++P+    +  V+      G ++   L+ + L+ TP++ 
Sbjct: 588  ATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLI-TPTVA 646

Query: 2955 TTNKKLADPVTL--------KIETKVLQPANLGS-TLTPHHPPALPSKL------PTEVN 2999
                + ADP  +           T    P   G+ +L P + P     L      PT   
Sbjct: 647  AFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASE 706

Query: 3000 HVPSGPSIPADRTVSHLAAAKLDAHSPR--------PSG--PGPSSFPRASHPS------ 3043
            + P  PS     T + LA   L    P+        P+G  PG       SH S      
Sbjct: 707  NCPVAPS--PQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVA 764

Query: 3044 ----------STASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHL 3093
                      S AS   S+  T+   A  P P  +S     +       S      + +L
Sbjct: 765  SSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNL 824

Query: 3094 SQGEVRMNTPTLPSITYSIR-----PEALHSPRAPLQPQQIEVRAPQRASTPQP----AP 3144
            S     +    LP  + S +     P   HSP  P         +P+ A TP      +P
Sbjct: 825  SSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPP---------SPKGAPTPSAVTPLSP 875

Query: 3145 AGVPALASQHPPEEEVHYHLPVA--RATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPH 3202
             GV     + P    V+   P       AP Q+  L M S       + P+  R    P 
Sbjct: 876  KGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTS-------SSPKKARATPAPK 928

Query: 3203 VTAVSEQPRAADGV-VKVPPASKA-PQQPGKEAAKTPDAKAAPTP-----TPAPVPVPVP 3255
                S  P+ A       PP+ K  P  P  + A TP A   P+P     TP+P   P P
Sbjct: 929  GIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTP 988

Query: 3256 LPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYH 3315
              A  P+P G       TPS   +G P TPP V     +           +  G      
Sbjct: 989  PAATPPSPKGG----PATPSP--KGAP-TPPAVTPPSPK----GSPAATPFPKG---AST 1034

Query: 3316 PPAQLTHTQ--FPAASSVGLPSRTKTAAQGPPPEGEPLQP-----PQPVQSTQPAQPAPP 3368
            PPA    +    PAA+ +   + T  AA  P P+G P  P     P P  +T P+    P
Sbjct: 1035 PPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGP 1094

Query: 3369 CPPSQLGQP----GQPPSSKMPQVSQEAKGTQT--GVEQPRLPAGPANRPPE--PHTQVQ 3420
              PS  G P      PPS K    +   KG  T      P    G A  PP+  P T   
Sbjct: 1095 ATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAA 1154

Query: 3421 RAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTE--- 3477
               +  G  + P P      P  P + P   +PK  L  P+  G  T P    P  +   
Sbjct: 1155 TPPSPKGGLATPPPKGA---PTTPAATP--PSPKGGLATPSPKGAPTTPAATPPSPKGGL 1209

Query: 3478 FQPAPK-QDSSPHLTSQRP 3495
              P+PK   ++P  T   P
Sbjct: 1210 ATPSPKGAPTTPAATPPSP 1228



 Score =  113 bits (283), Expect = 3e-24
 Identities = 277/1197 (23%), Positives = 403/1197 (33%), Gaps = 180/1197 (15%)

Query: 2400 SDLSKIPSTENSSQEISVE-ERTPTKASVPPDLPPPPQPAP-VDEEPQARFRVHSIIESD 2457
            S +S I  + + S  ++     +PT + +    P      P V + P +      ++ ++
Sbjct: 386  STISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTN 445

Query: 2458 PVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSP--PTKVTEWITRQEEPRAQ---- 2511
            P T  +      PT     A  +SPP++SG I +  P  P  +       +EP  Q    
Sbjct: 446  PCTIAA-----APTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATT 500

Query: 2512 ----------------STPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVT 2555
                            + PS  L       D+ T  ++L      P     T+    +V 
Sbjct: 501  LRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVL 560

Query: 2556 TAIAEPVSAAPCLHE---APPPPVD-----SKKPLEE-----KTAPPVTNNSEIQASEVL 2602
              +      +P       +P  P+      +KK L E     K A  +T+   + +S  +
Sbjct: 561  PLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASV 620

Query: 2603 VAADKEKVAPVIAPKI-TSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLV--- 2658
            +  D         P + +S+I+    +  LE++     A  AP T  G  +  T      
Sbjct: 621  IKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADP---AGVAPTTAKGTSTYTTTASPFL 677

Query: 2659 --NVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPV----- 2711
               VSL P N    PVK    T   LV T +    V   P N       ++  P      
Sbjct: 678  EGTVSLAPKNH---PVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSV 734

Query: 2712 -NATVGTVNAAPGT--------VNAAASAVNATASAVTVTAGAVTAAS--GGVTATTGTV 2760
             + ++      PGT         +A A   ++     T  +GA   AS  G +T    + 
Sbjct: 735  PSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSP 794

Query: 2761 TMAGAVIAPSTKCK--QRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLS 2818
            +  G  ++P TK    ++ SA  ++     S PV    P +A     L  N+      LS
Sbjct: 795  SPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPV---SPVEASF---LPENS------LS 842

Query: 2819 YSGQK-----TEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQA 2873
            + G K     T  P   S K +  P A         ++   +    SV     P +GP  
Sbjct: 843  FQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPAT 902

Query: 2874 PAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLT 2933
            PA     A   T   + +   A+P    + A  PS  K  P   + + P  +GG      
Sbjct: 903  PAPKQAPALSMTSS-SPKKARATPAPKGIPAS-PS-PKGAPTPPAATPPSPKGGPATPSP 959

Query: 2934 QGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSK 2993
            +   TPP              T       P T         P+  G+   P   P  P  
Sbjct: 960  KWAPTPPA------------ATPPSPKGGPAT---------PSPKGAPTPPAATPPSPKG 998

Query: 2994 LPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPS---STASTAL 3050
             P      PS    P    V+  +     A +P P G   S+ P A+ PS   S A+T L
Sbjct: 999  GPA----TPSPKGAPTPPAVTPPSPKGSPAATPFPKGA--STPPAATPPSPKGSPAATPL 1052

Query: 3051 STNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITY 3110
               A    AA +P P+   +    +    PP +   +      +        P  P+ T 
Sbjct: 1053 PKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSP--KGAPMPPAATP 1110

Query: 3111 SIRPEALHSPRAPLQPQQIEVRAPQ-RASTPQPAPAGVPALASQHPPEEEVHYHLPVARA 3169
                  L +P     P       P  +     P P G P   +  PP  +     P  + 
Sbjct: 1111 PSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKG 1170

Query: 3170 TAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQP 3229
             AP          +  L     P        P  T  S +   A    K  P + A   P
Sbjct: 1171 -APTTPAATPPSPKGGL---ATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPP 1226

Query: 3230 G-KEAAKTPDAKAAPTPTPAPVPVPVPLPAPA-PAPHGEARILTVTPSNQLQGLPLTPPV 3287
              K    TP  K APT TPA  P P P   PA P P G       TP +   GL   P  
Sbjct: 1227 SPKGGLATPSPKGAPT-TPAATP-PSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHK 1284

Query: 3288 VVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPE 3347
               +   +   S +       G   T  P    T    PAA+    P   K +   PPP+
Sbjct: 1285 GAPNPAVVTPPSPK-------GGPATSPPKGAPTP---PAAT----PPSPKGSPGTPPPK 1330

Query: 3348 GEP----LQPPQP-----VQSTQPAQ------------PAPPCP-PSQLGQPGQ-PPSSK 3384
            G P    + PP P     + +T P+             P PP   PS  G P   PPS K
Sbjct: 1331 GAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPK 1390

Query: 3385 MPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLP 3444
                    KG  T      +P  P   P  P T+   A    G  + P+   VS+K    
Sbjct: 1391 RGPAIPSPKGDPTSPAV--IPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLK---- 1444

Query: 3445 VSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQ---DSSPHLTSQRPVDM 3498
               P  +APK     P++ G  T P +  P  +  PAPKQ    SSP      P  M
Sbjct: 1445 -KAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPM 1500



 Score = 99.8 bits (247), Expect = 5e-20
 Identities = 382/1851 (20%), Positives = 594/1851 (32%), Gaps = 400/1851 (21%)

Query: 1616 HPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAP-SALEKTTGDKTVEAPLVTEEKTV 1674
            +P T  +AP    +  +    V PP      + S P S +E T+    V AP+  +E + 
Sbjct: 445  NPCTIAAAPT---TTFEVATCVSPP------MSSGPISNIEPTSPAALVMAPVAPKEPST 495

Query: 1675 EPATVSEEAKPASEPAPAPVEQLEQVDLPPGA----DPDKEAAMMPAGVEEGSSGDQPPY 1730
            + AT      P S P P P E L+  +LP          K+   +PA +E          
Sbjct: 496  QVATTLRI--PVSPPLPDP-EDLK--NLPSSVLVKFPTQKDLQTVPASLE---------- 540

Query: 1731 LDAKPPTPGASFSQAESNVDPEPDSTQ-PLSKPAQKSEEANEPKAEKPDATADAEPDANQ 1789
                    GA FS A++ +  + D T  PL + A K+  + +  +  P+     E    +
Sbjct: 541  --------GAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAK 592

Query: 1790 KAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDR 1849
            K+   P              P+     KP  S  S   V ++A S+++            
Sbjct: 593  KSLGEPL-------------PIG----KPASSMTSPLGVNSSA-SVIKTD---------- 624

Query: 1850 EKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYA 1909
                 S +    A  LL+  +    IT T +   A  LE  +P+     T +    S Y 
Sbjct: 625  -----SYAGPDSAGPLLKSSL----ITPTVA---AFPLESADPAGVAPTTAKGT--STYT 670

Query: 1910 TMGDH-----ENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEE 1964
            T          + +P   PV++  +T   L     E   V  +P                
Sbjct: 671  TTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSP---------------- 714

Query: 1965 ENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVK 2024
            +N     A  +  PE  +S  S      G P G K     KVD              G+ 
Sbjct: 715  QNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTK-----KVD--------------GIS 755

Query: 2025 ESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAP--------EKNSKSK 2076
             +S    A    A S ++   +D+G          +  +   P+P         K   +K
Sbjct: 756  HTS----ALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTK 811

Query: 2077 RGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQ 2136
            +G +       + S+ +  V+A+  P  + +  G ++S     SP    +P    G  + 
Sbjct: 812  KGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSP----TPPSPKGAPTP 867

Query: 2137 LKSDPVDPDKE--PEKEDVSASGPSPEATQLA--KQMELEQAVEHIAKLAEASASA--AY 2190
                P+ P     P KE      P+P    L   K+     A +    L+  S+S   A 
Sbjct: 868  SAVTPLSPKGVTLPPKET-----PTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKAR 922

Query: 2191 KADAPEGL--APEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQ 2248
               AP+G+  +P  +  P   A+ T  +   G         P    A PP P        
Sbjct: 923  ATPAPKGIPASPSPKGAPTPPAA-TPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPS 981

Query: 2249 P---PAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNS 2305
            P   P    A  PS +G     +  G          + P V  P P   P  T   +G S
Sbjct: 982  PKGAPTPPAATPPSPKGGPATPSPKGA--------PTPPAVTPPSPKGSPAATPFPKGAS 1033

Query: 2306 SETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGE 2365
            +  + + P  KGS           KG   T  +         + +P       S +    
Sbjct: 1034 TPPAATPPSPKGSP----AATPLPKGAPTTPAA--------TLPSPKGGPATPSLKGAPT 1081

Query: 2366 SPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKA 2425
             PAA   +    P  P  +     P +TPP S    L+  P     +   +         
Sbjct: 1082 PPAATPPSPKGGPATPSPKGAPMPPAATPP-SPKGGLATPPHKGAPTTPAATPPSPKGGL 1140

Query: 2426 SVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVA 2485
            + PP    P  PA     P+              TPP   +   PT P+ T     PP  
Sbjct: 1141 ATPPPKGAPTTPAATPPSPKGGL----------ATPPPKGA---PTTPAAT-----PPSP 1182

Query: 2486 SGGIPHQSPPTKVTEWITRQEEPR-AQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYV 2544
             GG+   SP    T        P+   +TPSP   P T A+   +           PK  
Sbjct: 1183 KGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPS-----------PKGG 1231

Query: 2545 SATSVTSTSVTTAIAEPVS-----AAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQAS 2599
             AT     + TT  A P S     A P    AP PP  +   L+   A P    +    +
Sbjct: 1232 LATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGA---PN 1288

Query: 2600 EVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVN 2659
              +V     K  P  +P   +           + S      K AP        +  G   
Sbjct: 1289 PAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPT 1348

Query: 2660 VSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVN 2719
            +     ++  GP   +  + K   + PA   +   GP      P      P      T  
Sbjct: 1349 LPATTPSSKGGP---TTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPT-- 1403

Query: 2720 AAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASA 2779
             +P  +    S   A A+ VT   GA T + G +T     VT      AP+T   +   A
Sbjct: 1404 -SPAVI--PLSPKKAPATPVT-REGAATPSKGDLTPP--AVTPVSLKKAPATSAPKGGPA 1457

Query: 2780 NENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPP 2839
              +S+  P    V    P +                                      PP
Sbjct: 1458 TPSSKGDPTLPAVTPPSPKE--------------------------------------PP 1479

Query: 2840 ASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVI 2899
            A                 P  V  S  P K P  PA        + +  + +   A+P  
Sbjct: 1480 A-----------------PKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATP-- 1520

Query: 2900 SSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKK 2959
                + R     P    LS  TP T      ++      PP +       TP+I T  + 
Sbjct: 1521 ----SSRRDPIAPTATLLSKKTPATLAPKEALI------PPAMTVPSPKKTPAIPTPKEA 1570

Query: 2960 LADPVTLKIET-KVLQPANLGSTLTPHH---PPALPSKLPTEVNHVPSGPSIPADRTVSH 3015
             A P + +  +   + P+      +P     PPA+ S  P E       P+ PA    S 
Sbjct: 1571 PATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKE------APTPPAVTPPSP 1624

Query: 3016 LAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAA-GIPVPQFISSIHPE 3074
                   A    P+ P  +       P+S AS      ATV  A+ G+P  +  +++  +
Sbjct: 1625 EKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTAL--K 1682

Query: 3075 QSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAP 3134
            + ++ P    T  ++       + + ++ T P I     P A +  + PL          
Sbjct: 1683 EVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPD--PSAKNGSKGPL---------- 1730

Query: 3135 QRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRD 3194
               ST  PAP       S    + +   H P     AP +S+           P T    
Sbjct: 1731 ---STVAPAPLLPVQKDSSKTAKGKDASHSPKG-PLAPPESKAST--------PLTAAAF 1778

Query: 3195 VRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPV 3254
             +++  P   +VS  P         PP S                  AP+P P   P   
Sbjct: 1779 EKVLPKPESASVSAAPS--------PPVS---------------LPLAPSPVPTLPPKQQ 1815

Query: 3255 PLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTY 3314
             LP+ +P    E+    + P+++ + LPL PP  ++ GV                     
Sbjct: 1816 FLPS-SPGLVLESPSKPLAPADEDELLPLIPPEPISGGV--------------------- 1853

Query: 3315 HPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQL 3374
              P Q      P   S G+P  T +A Q                         P   +  
Sbjct: 1854 --PFQSVLVNMPTPKSAGIPVPTPSAKQ-------------------------PVTKNNK 1886

Query: 3375 GQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAE 3425
            G   +  S +     +E   TQ   +Q +L A  A    EP ++ +++++E
Sbjct: 1887 GSGTESDSDESVPELEEQDSTQATTQQAQL-AAAAEIDEEPVSKAKQSRSE 1936



 Score = 79.7 bits (195), Expect = 5e-14
 Identities = 224/1066 (21%), Positives = 349/1066 (32%), Gaps = 188/1066 (17%)

Query: 1604 PKEVEKQEDTENHPKTPESAPENKDSELKTPPSVG---PPSVTVVTLESAPSALEKTTGD 1660
            PK        +  P  P + P +      TP   G   PP+VT  + + +P+A     G 
Sbjct: 973  PKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGA 1032

Query: 1661 KTVEAPLVTEEKTVEPATVSEEAKPASEPAP--APVEQLEQVDLPPG--ADPDKEAAMMP 1716
             T  A              S +  PA+ P P  AP      +  P G  A P  + A  P
Sbjct: 1033 STPPA----------ATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTP 1082

Query: 1717 AGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEK 1776
                  S    P    A P   GA    A +   P+     P  K A  +  A  P  + 
Sbjct: 1083 PAATPPSPKGGP----ATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKG 1138

Query: 1777 PDATADAEPDANQKAEAAPESQPPASEDLEVDPP-------VAAKDKKPNKSKRSKTPVQ 1829
              AT        + A   P + PP+ +     PP        AA    P     + +P  
Sbjct: 1139 GLATPPP-----KGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKG 1193

Query: 1830 AAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEH 1889
            A        P                 SP+G           A    + A    AA    
Sbjct: 1194 APTTPAATPP-----------------SPKGGL---------ATPSPKGAPTTPAA--TP 1225

Query: 1890 PEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPR 1949
            P P   L+    +   +  A         P   P +            L+   A P  P 
Sbjct: 1226 PSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATP--PH 1283

Query: 1950 RGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDAT 2009
            +G P      A     +    PA +  PP+G  +P     A    P+G  G   PK  A 
Sbjct: 1284 KGAP----NPAVVTPPSPKGGPATS--PPKGAPTP---PAATPPSPKGSPGTPPPK-GAP 1333

Query: 2010 RPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAP 2069
             P A T   P    K +   P       G       K+  T   PP   P      K  P
Sbjct: 1334 TPPAVTPPSP----KGTPTLPATTPSSKGGPTTPSSKEGPT---PPAATP----SHKGGP 1382

Query: 2070 EKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQ- 2128
                 S +   R   +   K          +SP+ A A    RE    A +P K +    
Sbjct: 1383 AMTPPSPK---RGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREG---AATPSKGDLTPP 1436

Query: 2129 -------KEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKL 2181
                   K+   +S  K  P  P  + +    + + PSP+     KQ+    A     K 
Sbjct: 1437 AVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQV----ATSSSPKK 1492

Query: 2182 AEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPG 2241
            A A+ +       P  +    ++ PA  +S  +  A   ++++      +  PA    P 
Sbjct: 1493 APATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLS------KKTPATLA-PK 1545

Query: 2242 ESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEA 2301
            E+   L PPA           + T +       T ++ E+S PP   P    G    KE 
Sbjct: 1546 EA---LIPPAMTVPSPKKTPAIPTPKEAPA---TPSSKEASSPPAVTPSTYKGAPSPKEL 1599

Query: 2302 RGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQ 2361
                + TS S  E                                   AP    V   + 
Sbjct: 1600 LIPPAVTSPSPKE-----------------------------------APTPPAVTPPSP 1624

Query: 2362 AQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERT 2421
             +G +  A +GT    P  P   K S       P S  S   K+ +T   + +    ++ 
Sbjct: 1625 EKGPATPAPKGTPTSPPVTPSSLKDS-------PTSPASVTCKMGATVPQASKGLPAKKG 1677

Query: 2422 PTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLS 2481
            PT A     + P P+  P+   P  +       ++   +  S P  P P+  + +   LS
Sbjct: 1678 PT-ALKEVLVAPAPESTPIITAPTRKGP-----QTKKSSATSPPICPDPSAKNGSKGPLS 1731

Query: 2482 PPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDP 2541
                +  +P Q   +K     T + +  + S   P  PP++KAS    +++   K+L  P
Sbjct: 1732 TVAPAPLLPVQKDSSK-----TAKGKDASHSPKGPLAPPESKAS-TPLTAAAFEKVLPKP 1785

Query: 2542 KYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEE--KTAPPVTNNSEIQAS 2599
            +        S SV+ A + PVS         P PV +  P ++   ++P +   S    S
Sbjct: 1786 E--------SASVSAAPSPPVSL-----PLAPSPVPTLPPKQQFLPSSPGLVLES---PS 1829

Query: 2600 EVLVAADKEKVAPVIAPK-ITSVISRMPVSIDLENSQKITLAKPAP 2644
            + L  AD++++ P+I P+ I+  +    V +++   +   +  P P
Sbjct: 1830 KPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTP 1875



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 105/464 (22%), Positives = 168/464 (36%), Gaps = 63/464 (13%)

Query: 1604 PKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTV 1663
            PKEV     +   P  P +   +K    KTP ++ P    +      P A+   +  KT 
Sbjct: 1513 PKEVPATPSSRRDPIAPTATLLSK----KTPATLAPKEALI------PPAMTVPSPKKTP 1562

Query: 1664 EAPLVTEEKTVEPATVSEEAKPASEP-----APAPVEQL--EQVDLPPGADPDKEAAMMP 1716
              P   +E    P++    + PA  P     AP+P E L    V  P   +     A+ P
Sbjct: 1563 AIP-TPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTP 1621

Query: 1717 AGVEEGSSGDQPPYLDAKPPTPGASFSQ---AESNVDPEPDSTQPLSK---PAQKSEEAN 1770
               E+G +   P      PP   +S      + ++V  +  +T P +    PA+K     
Sbjct: 1622 PSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKG---- 1677

Query: 1771 EPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQA 1830
             P A K    A A P++     A     P   +     PP+       N SK   + V  
Sbjct: 1678 -PTALKEVLVAPA-PESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAP 1735

Query: 1831 AAVSIVEKPVTRKSERIDREKLKRSNSPRG-----EAQKLLELKMEA-EKITRTASKNSA 1884
            A +  V+K  ++ ++  D      S+SP+G     E++    L   A EK+       S 
Sbjct: 1736 APLLPVQKDSSKTAKGKD-----ASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASV 1790

Query: 1885 ADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSP-----VKEPVEQPRVTRKRLERELQ 1939
            +    P  SLPL+        S   T+   +   P     V E   +P       E EL 
Sbjct: 1791 SAAPSPPVSLPLA-------PSPVPTLPPKQQFLPSSPGLVLESPSKPLAPAD--EDEL- 1840

Query: 1940 EAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKK 1999
                +P  P  G  P      +      A  P     P    + P + K   G G +   
Sbjct: 1841 -LPLIPPEPISGGVPFQSVLVNMPTPKSAGIPV----PTPSAKQPVT-KNNKGSGTESDS 1894

Query: 2000 GKNEPKV-DATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQK 2042
             ++ P++ +    +ATT+        E   EP +  +++ SE+K
Sbjct: 1895 DESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKK 1938



 Score = 41.2 bits (95), Expect = 0.019
 Identities = 41/143 (28%), Positives = 58/143 (40%), Gaps = 19/143 (13%)

Query: 3368 PCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETG 3427
            P    +L QP Q  ++ +P  S  +     G   P LP      P  P  Q     A   
Sbjct: 10   PATEQELPQP-QAETAVLPMSSALSVTAALGQPGPTLPP-----PCSPAPQQCPLSAANQ 63

Query: 3428 PTSFPSPVSVSMKP-DLP-------VSLPTQTAPKQPLFVPTTSGPS-TPPGLVLPHTEF 3478
             + FPSP +++  P ++P        +LP  TAP+ P F+P   GP  +P  L L     
Sbjct: 64   ASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMI 123

Query: 3479 QPAPKQDSSPHLTSQRPVDMVQL 3501
             P  K   S    S  P+ +V L
Sbjct: 124  APTLKGTPS----SSAPLALVAL 142



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 74/377 (19%), Positives = 128/377 (33%), Gaps = 77/377 (20%)

Query: 1624 PENKDSELKTPPSVGPPSVT------VVTLESAPSALEKTTGDKTVEA---------PLV 1668
            P+ K S   +PP    PS        + T+  AP    +    KT +          PL 
Sbjct: 1704 PQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLA 1763

Query: 1669 T-EEKTVEPATVSEEAKPASEP-------APAPVEQLEQVDLPPGADPDKEAAM--MPAG 1718
              E K   P T +   K   +P       AP+P   L     P    P K+  +   P  
Sbjct: 1764 PPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGL 1823

Query: 1719 VEEGSS-----GDQPPYLDAKPPTP---GASFSQAESNVDPEPDSTQPLSKPAQKSEEAN 1770
            V E  S      D+   L   PP P   G  F     N+     +  P+  P+ K     
Sbjct: 1824 VLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTK 1883

Query: 1771 EPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQA 1830
              K    ++ +D         E+ PE +                 ++ +    ++    A
Sbjct: 1884 NNKGSGTESDSD---------ESVPELE-----------------EQDSTQATTQQAQLA 1917

Query: 1831 AAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHP 1890
            AA  I E+PV++  +    +K +++ S  G     L       ++T   SKN    +  P
Sbjct: 1918 AAAEIDEEPVSKAKQSRSEKKARKAMSKLG-----LRQVTGVTRVTIRKSKNILFVITKP 1972

Query: 1891 EPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRR 1950
            +         +      Y   G+    + +++  +Q ++     E+   +  AV      
Sbjct: 1973 D-------VYKSPASDTYIVFGE----AKIEDLSQQAQLA--AAEKFKVQGEAVSNIQEN 2019

Query: 1951 GRPPKTRRRADEEEENE 1967
             + P  +  ++EEE +E
Sbjct: 2020 TQTPTVQEESEEEEVDE 2036



 Score = 32.3 bits (72), Expect = 8.9
 Identities = 69/300 (23%), Positives = 102/300 (34%), Gaps = 58/300 (19%)

Query: 3219 VPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQL 3278
            VP   +   QP  E A  P + A         P P   P  +PAP    +   ++ +NQ 
Sbjct: 9    VPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAP----QQCPLSAANQA 64

Query: 3279 QGLPLTPPVVVTHGVQI---VHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPS 3335
               P +P  + +  +++     SSG         +  T+ P   +     PAA ++  P 
Sbjct: 65   SPFP-SPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNL-IGPPISPAALALASPM 122

Query: 3336 RTKTAAQGPPPEGEPLQ----PPQPVQSTQPAQP-APPCPPS-QLGQPGQPPSSKMPQVS 3389
               T  +G P    PL      P  VQ +    P     PPS  + + G   +   P   
Sbjct: 123  IAPT-LKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAP 181

Query: 3390 QEAKGTQTGVEQPRLPAGPANRPPEP--------HTQVQRAQAETGPTSFP--------- 3432
             E K     V    +P  P   P  P        H     A  ++G  S P         
Sbjct: 182  SEPKTNLNKVPSEVVP-NPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLA 240

Query: 3433 -------------------SPVSVSMK----PDLPVSLPTQTAPKQPLFVPTTSGPSTPP 3469
                               +P S+S+K    P   +SL TQ+ P        T+GP+TPP
Sbjct: 241  IASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLP-VVTSSQKTAGPNTPP 299


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  130 bits (328), Expect = 2e-29
 Identities = 238/1278 (18%), Positives = 376/1278 (29%), Gaps = 129/1278 (10%)

Query: 2236 PPPYPGESQTDLQPPAGAQAL---QPSEEGMETDEAVSGILETEAATESSRPPVNAPDPS 2292
            P P P  +QT    P          P+  G +T         T   T ++  P   P  +
Sbjct: 2070 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT------TPITTTTTVTPTPTPTGT 2123

Query: 2293 AGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPV 2352
              PT T      ++ T    P   G++    T +        T      +      +   
Sbjct: 2124 QTPTTTPIT---TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2180

Query: 2353 ESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSS 2412
             +  P       ++P     TT            ++ P +T P + T+ ++  P+   + 
Sbjct: 2181 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP-TTTPITTTTTVTPTPTPTGT- 2238

Query: 2413 QEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTL 2472
                   +TPT   +       P P P   +      + +     P   P+    P  T 
Sbjct: 2239 -------QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2291

Query: 2473 PSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSS 2532
             + T      P  +G     + P   T  +T    P    TP+   P  T  +   T + 
Sbjct: 2292 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTVTPTPTP 2350

Query: 2533 TLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTN 2592
            T  +        + T+VT T   T    P +  P        P  +    +  T  P+T 
Sbjct: 2351 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTVTPTPTPTGTQTPTTTPITT 2409

Query: 2593 NSEIQASEVLVAADKEKVAPV-----IAPKITSVISRMPVSIDLENSQKITLAKPAPQTL 2647
             + +  +            P+     + P  T   ++ P +  +  +  +T       T 
Sbjct: 2410 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2469

Query: 2648 TGLVSALTGLVNVSLVPV-NALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNV 2706
            T   + +T    V+  P     + P    +TT  ++  TP  P          +T    V
Sbjct: 2470 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-PTGTQTPTTTPITTTTTV 2528

Query: 2707 LTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAV 2766
              TP      T    P T     +         T T   +T  +      T T T     
Sbjct: 2529 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2588

Query: 2767 IAPSTKCKQRASANENSRFHPGSMPV-----IDDRPADAGSGAGLRV---NTSEGVVLLS 2818
               +T      +        P + P+     +   P   G+          T+      +
Sbjct: 2589 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2648

Query: 2819 YSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYA 2878
             +G +T     I+   +  P  +       Q+ + + +   +     P   G Q P    
Sbjct: 2649 PTGTQTPTTTPITTTTTVTPTPTPTGT---QTPTTTPITTTTTVTPTPTPTGTQTPT--T 2703

Query: 2879 NVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINT 2938
               T +T V    T   +   ++      +   P P      TP T   T    T  +  
Sbjct: 2704 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTP 2760

Query: 2939 PPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTP-------HHPPALP 2991
             P     Q   T  I TT      P     +T    P    +T+TP         P   P
Sbjct: 2761 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2820

Query: 2992 SKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPG-PSSFPRASH------PSS 3044
                T V   P+ P+     T + +        +P P+G   P++ P  +       P+ 
Sbjct: 2821 ITTTTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2879

Query: 3045 TASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPT 3104
            T +   +T          P P    +  P  + I    ++T T +            TPT
Sbjct: 2880 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQTPT 2932

Query: 3105 LPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHL 3164
               IT +       +P     P    +       TP P P G     +Q P    +    
Sbjct: 2933 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-TPTPTPTG-----TQTPTTTPITTTT 2986

Query: 3165 PVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASK 3224
             V     P  ++           P T P      V P  T    Q      +      + 
Sbjct: 2987 TVTPTPTPTGTQT----------PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 3036

Query: 3225 APQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLT 3284
             P   G +   T       T TP P P     P   P        +T TP+      P T
Sbjct: 3037 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT--TTTTVTPTPTPTGTQTPTT 3094

Query: 3285 PPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGP 3344
             P+  T                      T  P    T TQ P  + +   + T T    P
Sbjct: 3095 TPITTT---------------------TTVTPTPTPTGTQTPTTTPI---TTTTTVTPTP 3130

Query: 3345 PPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQV--SQEAKGTQTGVEQP 3402
             P G       P+ +T    P P   P+    P   P +    V  +    GTQT     
Sbjct: 3131 TPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQT----- 3183

Query: 3403 RLPAGPANRPPEPHTQVQRAQAETG---PTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFV 3459
                 P   P    T V      TG   PT+ P   + ++ P  P    TQT    P+  
Sbjct: 3184 -----PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITT 3237

Query: 3460 PTTSGPS-TPPGLVLPHT 3476
             TT  P+ TP G   P T
Sbjct: 3238 TTTVTPTPTPTGTQTPTT 3255



 Score =  130 bits (328), Expect = 2e-29
 Identities = 238/1278 (18%), Positives = 376/1278 (29%), Gaps = 129/1278 (10%)

Query: 2236 PPPYPGESQTDLQPPAGAQAL---QPSEEGMETDEAVSGILETEAATESSRPPVNAPDPS 2292
            P P P  +QT    P          P+  G +T         T   T ++  P   P  +
Sbjct: 2852 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT------TPITTTTTVTPTPTPTGT 2905

Query: 2293 AGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPV 2352
              PT T      ++ T    P   G++    T +        T      +      +   
Sbjct: 2906 QTPTTTPIT---TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2962

Query: 2353 ESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSS 2412
             +  P       ++P     TT            ++ P +T P + T+ ++  P+   + 
Sbjct: 2963 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP-TTTPITTTTTVTPTPTPTGT- 3020

Query: 2413 QEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTL 2472
                   +TPT   +       P P P   +      + +     P   P+    P  T 
Sbjct: 3021 -------QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3073

Query: 2473 PSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSS 2532
             + T      P  +G     + P   T  +T    P    TP+   P  T  +   T + 
Sbjct: 3074 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT-TTPITTTTTVTPTPTP 3132

Query: 2533 TLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTN 2592
            T  +        + T+VT T   T    P +  P        P  +    +  T  P+T 
Sbjct: 3133 TGTQTPTTTPITTTTTVTPTPTPTGTQTP-TTTPITTTTTVTPTPTPTGTQTPTTTPITT 3191

Query: 2593 NSEIQASEVLVAADKEKVAPV-----IAPKITSVISRMPVSIDLENSQKITLAKPAPQTL 2647
             + +  +            P+     + P  T   ++ P +  +  +  +T       T 
Sbjct: 3192 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3251

Query: 2648 TGLVSALTGLVNVSLVPV-NALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNV 2706
            T   + +T    V+  P     + P    +TT  ++  TP  P          +T    V
Sbjct: 3252 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-PTGTQTPTTTPITTTTTV 3310

Query: 2707 LTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAV 2766
              TP      T    P T     +         T T   +T  +      T T T     
Sbjct: 3311 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3370

Query: 2767 IAPSTKCKQRASANENSRFHPGSMPV-----IDDRPADAGSGAGLR---VNTSEGVVLLS 2818
               +T      +        P + P+     +   P   G+          T+      +
Sbjct: 3371 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3430

Query: 2819 YSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYA 2878
             +G +T     I+   +  P  +       Q+ + + +   +     P   G Q P    
Sbjct: 3431 PTGTQTPTTTPITTTTTVTPTPTPTG---TQTPTTTPITTTTTVTPTPTPTGTQTPT--T 3485

Query: 2879 NVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINT 2938
               T +T V    T   +   ++      +   P P      TP T   T    T  +  
Sbjct: 3486 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTP 3542

Query: 2939 PPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTP-------HHPPALP 2991
             P     Q   T  I TT      P     +T    P    +T+TP         P   P
Sbjct: 3543 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3602

Query: 2992 SKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSG-PGPSSFPRAS------HPSS 3044
                T V   P+ P+     T + +        +P P+G   P++ P  +       P+ 
Sbjct: 3603 ITTTTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3661

Query: 3045 TASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPT 3104
            T +   +T          P P    +  P  + I    ++T T +            TPT
Sbjct: 3662 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQTPT 3714

Query: 3105 LPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHL 3164
               IT +       +P     P    +       TP P P G     +Q P    +    
Sbjct: 3715 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-TPTPTPTG-----TQTPTTTPITTTT 3768

Query: 3165 PVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASK 3224
             V     P  ++           P T P      V P  T    Q      +      + 
Sbjct: 3769 TVTPTPTPTGTQT----------PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 3818

Query: 3225 APQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLT 3284
             P   G +   T       T TP P P     P   P        +T TP+      P T
Sbjct: 3819 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT--TTTTVTPTPTPTGTQTPTT 3876

Query: 3285 PPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGP 3344
             P+  T                      T  P    T TQ P  + +   + T T    P
Sbjct: 3877 TPITTT---------------------TTVTPTPTPTGTQTPTTTPI---TTTTTVTPTP 3912

Query: 3345 PPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQV--SQEAKGTQTGVEQP 3402
             P G       P+ +T    P P   P+    P   P +    V  +    GTQT     
Sbjct: 3913 TPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQT----- 3965

Query: 3403 RLPAGPANRPPEPHTQVQRAQAETG---PTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFV 3459
                 P   P    T V      TG   PT+ P   + ++ P  P    TQT    P+  
Sbjct: 3966 -----PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITT 4019

Query: 3460 PTTSGPS-TPPGLVLPHT 3476
             TT  P+ TP G   P T
Sbjct: 4020 TTTVTPTPTPTGTQTPTT 4037



 Score =  130 bits (327), Expect = 2e-29
 Identities = 242/1273 (19%), Positives = 378/1273 (29%), Gaps = 142/1273 (11%)

Query: 2236 PPPYPGESQTDLQPPAGAQAL---QPSEEGMETDEAVSGILETEAATESSRPPVNAPDPS 2292
            P P P  +QT    P          P+  G +T         T   T ++  P   P  +
Sbjct: 1909 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT------TPITTTTTVTPTPTPTGT 1962

Query: 2293 AGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPV 2352
              PT T      ++ T    P   G++    T +        T      +      +   
Sbjct: 1963 QTPTTTPIT---TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2019

Query: 2353 ESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSS 2412
             +  P       ++P     TT            ++ P +T P + T+ ++  P+   + 
Sbjct: 2020 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP-TTTPITTTTTVTPTPTPTGT- 2077

Query: 2413 QEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTL 2472
                   +TPT   +       P P P   +      + +     P   P+    P  T 
Sbjct: 2078 -------QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2130

Query: 2473 PSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSS 2532
             + T      P  +G     + P   T  +T    P    TP+   P  T  +   T + 
Sbjct: 2131 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTVTPTPTP 2189

Query: 2533 TLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTN 2592
            T  +        + T+VT T   T    P +  P        P  +    +  T  P+T 
Sbjct: 2190 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTVTPTPTPTGTQTPTTTPITT 2248

Query: 2593 NSEIQASEVLVAADKEKVAPV-----IAPKITSVISRMPVSIDLENSQKITLAKPAPQTL 2647
             + +  +            P+     + P  T   ++ P +  +  +  +T       T 
Sbjct: 2249 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2308

Query: 2648 TGLVSALTGLVNVSLVPV-NALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNV 2706
            T   + +T    V+  P     + P    +TT  ++  TP              TG    
Sbjct: 2309 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP------------TGTQTP 2356

Query: 2707 LTTPVNATVGTVNAAP---GTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMA 2763
             TTP+  T  TV   P   GT     + +  T + VT T       +   T  T T T+ 
Sbjct: 2357 TTTPITTTT-TVTPTPTPTGTQTPTTTPITTTTT-VTPTPTPTGTQTPTTTPITTTTTVT 2414

Query: 2764 GAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQK 2823
                   T+          +   P   P     P          V  +      + +G +
Sbjct: 2415 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP-----TPTGTQ 2469

Query: 2824 TEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATH 2883
            T     I+   +  P  +       Q+ + + +   +     P   G Q P       T 
Sbjct: 2470 TPTTTPITTTTTVTPTPTPTGT---QTPTTTPITTTTTVTPTPTPTGTQTPT--TTPITT 2524

Query: 2884 STLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLV 2943
            +T V    T   +   ++      +   P P      TP T   T    T  +   P   
Sbjct: 2525 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPT 2581

Query: 2944 HNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTP-------HHPPALPSKLPT 2996
              Q   T  I TT      P     +T    P    +T+TP         P   P    T
Sbjct: 2582 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 2641

Query: 2997 EVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPG-PSSFPRASH------PSSTASTA 3049
             V   P+ P+     T + +        +P P+G   P++ P  +       P+ T +  
Sbjct: 2642 TVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2700

Query: 3050 LSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSIT 3109
             +T          P P    +  P  + I    ++T T +            TPT   IT
Sbjct: 2701 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQTPTTTPIT 2753

Query: 3110 YSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARA 3169
             +       +P     P    +       TP P P G     +Q P    +     V   
Sbjct: 2754 TTTTVTPTPTPTGTQTPTTTPITTTTTV-TPTPTPTG-----TQTPTTTPITTTTTVTPT 2807

Query: 3170 TAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQP 3229
              P  ++           P T P      V P  T    Q      +      +  P   
Sbjct: 2808 PTPTGTQT----------PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2857

Query: 3230 GKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVV 3289
            G +   T       T TP P P     P   P        +T TP+      P T P+  
Sbjct: 2858 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT--TTTTVTPTPTPTGTQTPTTTPITT 2915

Query: 3290 THGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGE 3349
            T                      T  P    T TQ P  + +   + T T    P P G 
Sbjct: 2916 T---------------------TTVTPTPTPTGTQTPTTTPI---TTTTTVTPTPTPTGT 2951

Query: 3350 PLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQV--SQEAKGTQTGVEQPRLPAG 3407
                  P+ +T    P P   P+    P   P +    V  +    GTQT          
Sbjct: 2952 QTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQT---------- 2999

Query: 3408 PANRPPEPHTQVQRAQAETG---PTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSG 3464
            P   P    T V      TG   PT+ P   + ++ P  P    TQT    P+   TT  
Sbjct: 3000 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 3058

Query: 3465 PS-TPPGLVLPHT 3476
            P+ TP G   P T
Sbjct: 3059 PTPTPTGTQTPTT 3071



 Score =  129 bits (324), Expect = 5e-29
 Identities = 269/1314 (20%), Positives = 386/1314 (29%), Gaps = 171/1314 (13%)

Query: 2230 PENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAP 2289
            P   P+PPP    + T   PP    +   +     T    +        T ++ PP   P
Sbjct: 1402 PTTTPSPPP----TSTTTLPPTTTPSPPTTTT---TTPPPTTTPSPPITTTTTPPPTTTP 1454

Query: 2290 DPSAGPTDTKEARGNSSE--TSHSVPEAKGSKEVEVTLVRKDKGRQKT-TRSRRKRNTNK 2346
             P    T T       S   T+ S P    S     T            T +      + 
Sbjct: 1455 SPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPAST 1514

Query: 2347 KVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIP 2406
              + P  +  P +       P          P  P     +  P +TP    T+  +  P
Sbjct: 1515 TTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPP 1574

Query: 2407 STENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPS 2466
            +T  S    +         + PP    P  P      P       +   S P T P  P 
Sbjct: 1575 TTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPP-----TTTPSPPTTTPITPP 1629

Query: 2467 IPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASD 2526
                TLP  T    SPP          P T  T   T    P   +TPSP +   T    
Sbjct: 1630 TSTTTLPPTTTP--SPP----------PTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPP 1677

Query: 2527 VDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPV--SAAPCLHEAP-PPPVDSKKPLE 2583
              T SS +      P     T++T+ S TT  + P+  +  P     P PPP     P  
Sbjct: 1678 TTTPSSPITTTPSPP----TTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSP 1733

Query: 2584 EKT-APPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVS---IDLEN------ 2633
              T +PP T  + +  +          + P I P   S  S    +   + L N      
Sbjct: 1734 TTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLD 1793

Query: 2634 SQKITLAKPAPQT-LTGLVSALTGLVNVSL-------VPVNALKGPVKGSVTT---LKSL 2682
            S K    KP   T L G V       N+S        VP+  L   V   V+     K+ 
Sbjct: 1794 SGKPNFHKPGGDTELIGDVCGPGWAANISCRATMYPDVPIGQLGQTVVCDVSVGLICKNE 1853

Query: 2683 VSTPAGPVNV---LKGPVNV-----LTGPVNVLTT-------PVNATVGTVNAAPGTVNA 2727
               P G + +   L   +NV     +T P  + TT       P    + T      T   
Sbjct: 1854 DQKPGGVIPMAFCLNYEINVQCCECVTQPTTMTTTTTENPTPPTTTPITTTTTVTPTPTP 1913

Query: 2728 AASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPS-----TKCKQRASANEN 2782
              +    T    T T    T    G    T T       + P+     T+          
Sbjct: 1914 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 1973

Query: 2783 SRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASA 2842
            +   P   P     P          V  +      + +G +T     I+   +  P  + 
Sbjct: 1974 TTVTPTPTPTGTQTPTTTPITTTTTVTPTP-----TPTGTQTPTTTPITTTTTVTPTPTP 2028

Query: 2843 MDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSV 2902
                  Q+ + + +   +     P   G Q P       T +T V    T   +   ++ 
Sbjct: 2029 TG---TQTPTTTPITTTTTVTPTPTPTGTQTPT--TTPITTTTTVTPTPTPTGTQTPTTT 2083

Query: 2903 KADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLAD 2962
                 +   P P      TP T   T    T  +   P     Q   T  I TT      
Sbjct: 2084 PITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2140

Query: 2963 PVTLKIETKVLQPANLGSTLTP-------HHPPALPSKLPTEVNHVPSGPSIPADRTVSH 3015
            P     +T    P    +T+TP         P   P    T V   P+ P+     T + 
Sbjct: 2141 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-PTGTQTPTTTP 2199

Query: 3016 LAAAKLDAHSPRPSG-PGPSSFPRAS------HPSSTASTALSTNATVMLAAGIPVPQFI 3068
            +        +P P+G   P++ P  +       P+ T +   +T          P P   
Sbjct: 2200 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2259

Query: 3069 SSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQ 3128
             +  P  + I    ++T T +            TPT   IT +       +P     P  
Sbjct: 2260 GTQTPTTTPITTTTTVTPTPT-------PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2312

Query: 3129 IEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHP 3188
              +       TP P P G     +Q P    +     V     P  ++           P
Sbjct: 2313 TPITTTTTV-TPTPTPTG-----TQTPTTTPITTTTTVTPTPTPTGTQT----------P 2356

Query: 3189 YTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPA 3248
             T P      V P  T    Q      +      +  P   G +   T       T TP 
Sbjct: 2357 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2416

Query: 3249 PVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRY 3308
            P P     P   P        +T TP+      P T P+  T                  
Sbjct: 2417 PTPTGTQTPTTTPIT--TTTTVTPTPTPTGTQTPTTTPITTT------------------ 2456

Query: 3309 GDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPP 3368
                T  P    T TQ P  + +   + T T    P P G       P+ +T    P P 
Sbjct: 2457 ---TTVTPTPTPTGTQTPTTTPI---TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP- 2509

Query: 3369 CPPSQLGQPGQPPSSKMPQV--SQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAET 3426
              P+    P   P +    V  +    GTQT          P   P    T V      T
Sbjct: 2510 -TPTGTQTPTTTPITTTTTVTPTPTPTGTQT----------PTTTPITTTTTVTPTPTPT 2558

Query: 3427 G---PTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPS-TPPGLVLPHT 3476
            G   PT+ P   + ++ P  P    TQT    P+   TT  P+ TP G   P T
Sbjct: 2559 GTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2611



 Score =  127 bits (320), Expect = 2e-28
 Identities = 217/1110 (19%), Positives = 333/1110 (30%), Gaps = 132/1110 (11%)

Query: 2386 QSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQ 2445
            ++  P +T P + T+ ++  P+   +        +TPT   +       P P P   +  
Sbjct: 1891 ENPTPPTTTPITTTTTVTPTPTPTGT--------QTPTTTPITTTTTVTPTPTPTGTQTP 1942

Query: 2446 ARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQ 2505
                + +     P   P+    P  T  + T      P  +G     + P   T  +T  
Sbjct: 1943 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2002

Query: 2506 EEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAA 2565
              P    TP+   P  T  +   T + T  +        + T+VT T   T    P +  
Sbjct: 2003 PTPTGTQTPTTT-PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT- 2060

Query: 2566 PCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPV-----IAPKITS 2620
            P        P  +    +  T  P+T  + +  +            P+     + P  T 
Sbjct: 2061 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2120

Query: 2621 VISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPV-NALKGPVKGSVTTL 2679
              ++ P +  +  +  +T       T T   + +T    V+  P     + P    +TT 
Sbjct: 2121 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2180

Query: 2680 KSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAP---GTVNAAASAVNATA 2736
             ++  TP              TG     TTP+  T  TV   P   GT     + +  T 
Sbjct: 2181 TTVTPTPTP------------TGTQTPTTTPITTTT-TVTPTPTPTGTQTPTTTPITTTT 2227

Query: 2737 SAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDR 2796
            + VT T       +   T  T T T+        T+          +   P   P     
Sbjct: 2228 T-VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2286

Query: 2797 PADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQV 2856
            P          V  +      + +G +T     I+   +  P  +       Q+ + + +
Sbjct: 2287 PTTTPITTTTTVTPTP-----TPTGTQTPTTTPITTTTTVTPTPTPTGT---QTPTTTPI 2338

Query: 2857 KPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIH 2916
               +     P   G Q P       T +T V    T   +   ++      +   P P  
Sbjct: 2339 TTTTTVTPTPTPTGTQTPT--TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2396

Query: 2917 LSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPA 2976
                TP T   T    T  +   P     Q   T  I TT      P     +T    P 
Sbjct: 2397 TGTQTPTT---TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2453

Query: 2977 NLGSTLTPHHPPA---LPSKLP-TEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPG 3032
               +T+TP   P     P+  P T    V   P+    +T +          +P P+  G
Sbjct: 2454 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2513

Query: 3033 PSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSH 3092
              +      P++T  T  +T        G   P               P + T TV+ + 
Sbjct: 2514 TQT------PTTTPITTTTTVTPTPTPTGTQTPT------------TTPITTTTTVTPTP 2555

Query: 3093 LSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALAS 3152
               G     TPT   IT +       +P     P    +       TP P P G     +
Sbjct: 2556 TPTGT---QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-TPTPTPTG-----T 2606

Query: 3153 QHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRA 3212
            Q P    +     V     P  ++           P T P      V P  T    Q   
Sbjct: 2607 QTPTTTPITTTTTVTPTPTPTGTQT----------PTTTPITTTTTVTPTPTPTGTQTPT 2656

Query: 3213 ADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTV 3272
               +      +  P   G +   T       T TP P P     P   P        +T 
Sbjct: 2657 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT--TTTTVTP 2714

Query: 3273 TPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVG 3332
            TP+      P T P+  T                      T  P    T TQ P  + + 
Sbjct: 2715 TPTPTGTQTPTTTPITTT---------------------TTVTPTPTPTGTQTPTTTPI- 2752

Query: 3333 LPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQV--SQ 3390
              + T T    P P G       P+ +T    P P   P+    P   P +    V  + 
Sbjct: 2753 --TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTP 2808

Query: 3391 EAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETG---PTSFPSPVSVSMKPDLPVSL 3447
               GTQT          P   P    T V      TG   PT+ P   + ++ P  P   
Sbjct: 2809 TPTGTQT----------PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-TPTPT 2857

Query: 3448 PTQTAPKQPLFVPTTSGPS-TPPGLVLPHT 3476
             TQT    P+   TT  P+ TP G   P T
Sbjct: 2858 GTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2887



 Score =  125 bits (313), Expect = 1e-27
 Identities = 234/1147 (20%), Positives = 342/1147 (29%), Gaps = 156/1147 (13%)

Query: 2393 TPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHS 2452
            T P   T+  S  P++  +    +      T  + PP    P  P      P        
Sbjct: 1397 TTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSP 1456

Query: 2453 IIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQS 2512
             I +    PP+    P  T PS      SPP  +   P   P T  +   T    P A +
Sbjct: 1457 PISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTP--PPTTTPSPPTTTPITPPAST 1514

Query: 2513 TPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAA---PCLH 2569
            T    LPP T  S   T+++T             T+  S   TT I  P S     P   
Sbjct: 1515 T---TLPPTTTPSPPTTTTTT----------PPPTTTPSPPTTTPITPPTSTTTLPPTTT 1561

Query: 2570 EAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVS- 2628
             +PPP   +  P     +PP T       S   +           +P  T+  +  P + 
Sbjct: 1562 PSPPPTTTTTPPPTTTPSPPTTTT----PSPPTITTTTPPPTTTPSPPTTTTTTPPPTTT 1617

Query: 2629 ------------IDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSV 2676
                                 T   P P T T      T     +  P   +        
Sbjct: 1618 PSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPP 1677

Query: 2677 TTLKS--LVSTPAGPVNVL--KGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAV 2732
            TT  S  + +TP+ P   +    P    + P+   TTP + T  T +  P T+   +   
Sbjct: 1678 TTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTT--TPSPPPTTMTTPSPTT 1735

Query: 2733 NATASAVTVTAGAVTAASGGVTAT------TGTVTMAGAVIAPSTKCKQRAS-----ANE 2781
              +    T+T    T  S  +T T      T       +   P+T C    +      + 
Sbjct: 1736 TPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLDSG 1795

Query: 2782 NSRFH-PGSMPVIDDRPADAGSGAGLRVN-TSEGVVLLSYSGQKTEGPQRISAKISQ--- 2836
               FH PG    +       G  A +    T    V +   GQ       +         
Sbjct: 1796 KPNFHKPGGDTELIGDVCGPGWAANISCRATMYPDVPIGQLGQTVVCDVSVGLICKNEDQ 1855

Query: 2837 -----IPPASAMDIEFQQSVSKSQVKPDSV--TASQPPSKGPQAPAGYANVATHSTLVLT 2889
                 IP A  ++ E      +   +P ++  T ++ P+     P       T +     
Sbjct: 1856 KPGGVIPMAFCLNYEINVQCCECVTQPTTMTTTTTENPTPPTTTPITTTTTVTPTPTPTG 1915

Query: 2890 AQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVL 2949
             QT   +P+ ++          P P      TP T   T    T  +   P     Q   
Sbjct: 1916 TQTPTTTPITTTTTV------TPTPTPTGTQTPTT---TPITTTTTVTPTPTPTGTQTPT 1966

Query: 2950 TPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTP-------HHPPALPSKLPTEVNHVP 3002
            T  I TT      P     +T    P    +T+TP         P   P    T V   P
Sbjct: 1967 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2026

Query: 3003 SGPSIPADRTVSHLAAAKLDAHSPRPSG-PGPSSFPRAS------HPSSTASTALSTNAT 3055
            + P+     T + +        +P P+G   P++ P  +       P+ T +   +T   
Sbjct: 2027 T-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2085

Query: 3056 VMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPE 3115
                   P P    +  P  + I    ++T T +            TPT   IT +    
Sbjct: 2086 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQTPTTTPITTTTTVT 2138

Query: 3116 ALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQS 3175
               +P     P    +       TP P P G     +Q P    +     V     P  +
Sbjct: 2139 PTPTPTGTQTPTTTPITTTTTV-TPTPTPTG-----TQTPTTTPITTTTTVTPTPTPTGT 2192

Query: 3176 EVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAK 3235
            +           P T P      V P  T    Q      +      +  P   G +   
Sbjct: 2193 QT----------PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPT 2242

Query: 3236 TPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQI 3295
            T       T TP P P     P   P        +T TP+      P T P+  T     
Sbjct: 2243 TTPITTTTTVTPTPTPTGTQTPTTTPIT--TTTTVTPTPTPTGTQTPTTTPITTT----- 2295

Query: 3296 VHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQ 3355
                             T  P    T TQ P  + +   + T T    P P G       
Sbjct: 2296 ----------------TTVTPTPTPTGTQTPTTTPI---TTTTTVTPTPTPTGTQTPTTT 2336

Query: 3356 PVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQV--SQEAKGTQTGVEQPRLPAGPANRPP 3413
            P+ +T    P P   P+    P   P +    V  +    GTQT          P   P 
Sbjct: 2337 PITTTTTVTPTP--TPTGTQTPTTTPITTTTTVTPTPTPTGTQT----------PTTTPI 2384

Query: 3414 EPHTQVQRAQAETG---PTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPS-TPP 3469
               T V      TG   PT+ P   + ++ P  P    TQT    P+   TT  P+ TP 
Sbjct: 2385 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVTPTPTPT 2443

Query: 3470 GLVLPHT 3476
            G   P T
Sbjct: 2444 GTQTPTT 2450



 Score =  119 bits (297), Expect = 7e-26
 Identities = 224/1235 (18%), Positives = 365/1235 (29%), Gaps = 127/1235 (10%)

Query: 2236 PPPYPGESQTDLQPPAGAQAL---QPSEEGMETDEAVSGILETEAATESSRPPVNAPDPS 2292
            P P P  +QT    P          P+  G +T         T   T ++  P   P  +
Sbjct: 3174 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT------TPITTTTTVTPTPTPTGT 3227

Query: 2293 AGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPV 2352
              PT T      ++ T    P   G++    T +        T      +      +   
Sbjct: 3228 QTPTTTPIT---TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3284

Query: 2353 ESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSS 2412
             +  P       ++P     TT            ++ P +T P + T+ ++  P+   + 
Sbjct: 3285 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP-TTTPITTTTTVTPTPTPTGT- 3342

Query: 2413 QEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTL 2472
                   +TPT   +       P P P   +      + +     P   P+    P  T 
Sbjct: 3343 -------QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3395

Query: 2473 PSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSS 2532
             + T      P  +G     + P   T  +T    P    TP+   P  T  +   T + 
Sbjct: 3396 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTVTPTPTP 3454

Query: 2533 TLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTN 2592
            T  +        + T+VT T   T    P +  P        P  +    +  T  P+T 
Sbjct: 3455 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTVTPTPTPTGTQTPTTTPITT 3513

Query: 2593 NSEIQASEVLVAADKEKVAPV-----IAPKITSVISRMPVSIDLENSQKITLAKPAPQTL 2647
             + +  +            P+     + P  T   ++ P +  +  +  +T       T 
Sbjct: 3514 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3573

Query: 2648 TGLVSALTGLVNVSLVPV-NALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNV 2706
            T   + +T    V+  P     + P    +TT  ++  TP  P          +T    V
Sbjct: 3574 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-PTGTQTPTTTPITTTTTV 3632

Query: 2707 LTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAV 2766
              TP      T    P T     +         T T   +T  +      T T T     
Sbjct: 3633 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3692

Query: 2767 IAPSTKCKQRASANENSRFHPGSMPV-----IDDRPADAGSGAGLRV---NTSEGVVLLS 2818
               +T      +        P + P+     +   P   G+          T+      +
Sbjct: 3693 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3752

Query: 2819 YSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYA 2878
             +G +T     I+   +  P  +       Q+ + + +   +     P   G Q P    
Sbjct: 3753 PTGTQTPTTTPITTTTTVTPTPTPTGT---QTPTTTPITTTTTVTPTPTPTGTQTPT--T 3807

Query: 2879 NVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINT 2938
               T +T V    T   +   ++      +   P P      TP T   T    T  +  
Sbjct: 3808 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTP 3864

Query: 2939 PPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTP-------HHPPALP 2991
             P     Q   T  I TT      P     +T    P    +T+TP         P   P
Sbjct: 3865 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3924

Query: 2992 SKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPG-PSSFPRASH------PSS 3044
                T V   P+ P+     T + +        +P P+G   P++ P  +       P+ 
Sbjct: 3925 ITTTTTVTPTPT-PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3983

Query: 3045 TASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPT 3104
            T +   +T          P P    +  P  + I    ++T T +            TPT
Sbjct: 3984 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQTPT 4036

Query: 3105 LPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHL 3164
               IT +       +P     P    +       TP P P G     +Q P    +    
Sbjct: 4037 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV-TPTPTPTG-----TQTPTTTPITTTT 4090

Query: 3165 PVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASK 3224
             V     P  ++           P T P      V P  T    Q      +      + 
Sbjct: 4091 TVTPTPTPTGTQT----------PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 4140

Query: 3225 APQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLT 3284
             P   G +   T       T TP P P     P   P         TVTP+    G    
Sbjct: 4141 TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI----TTTTTVTPTPTPTGTQTG 4196

Query: 3285 PPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGP 3344
            PP          H+S     E     + T +PP + +  Q   ++S  L   T   +  P
Sbjct: 4197 PP---------THTSTAPIAE-----LTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLP 4242

Query: 3345 PPEGEPLQPPQPVQSTQPAQPAPPCPPSQLG---QPGQPPSSKMPQVSQEAKGTQTGVEQ 3401
            P           ++ T  A P+ P  P+          PPS+         +GT TG   
Sbjct: 4243 P----------AIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTG--- 4289

Query: 3402 PRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVS 3436
                   ++  P P T      +   PT  P+P+S
Sbjct: 4290 -------SSSAPTPSTVQTTTTSAWTPT--PTPLS 4315



 Score =  113 bits (283), Expect = 3e-24
 Identities = 249/1312 (18%), Positives = 377/1312 (28%), Gaps = 208/1312 (15%)

Query: 2230 PENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAP 2289
            P   P+PP     + T + PP     L P+                   T ++ PP   P
Sbjct: 1535 PTTTPSPP-----TTTPITPPTSTTTLPPTTTP-----------SPPPTTTTTPPPTTTP 1578

Query: 2290 DPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVV 2349
             P   PT T  +    + T+              T           T +     T+   +
Sbjct: 1579 SP---PTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTL 1635

Query: 2350 APVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTE 2409
             P  +  P         P            +P     +  P +T P S  +     P+T 
Sbjct: 1636 PPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTT 1695

Query: 2410 NSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPI 2469
             ++   +    +P   +  P     P P P            ++    P T PS P+  +
Sbjct: 1696 MTTPSPTTTPSSPITTTTTPSSTTTPSPPPT-----------TMTTPSPTTTPSPPTTTM 1744

Query: 2470 PTLPSVTAAK----------LSPPVAS----------------------GGIPHQSPPTK 2497
             TLP  T +           ++PP  S                       G P+   P  
Sbjct: 1745 TTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLDSGKPNFHKPGG 1804

Query: 2498 VTEWITRQEEP------RAQSTPSPALPPDTKASDV--DTSSSTLRKIL------MDPKY 2543
             TE I     P        ++T  P +P       V  D S   + K        + P  
Sbjct: 1805 DTELIGDVCGPGWAANISCRATMYPDVPIGQLGQTVVCDVSVGLICKNEDQKPGGVIPMA 1864

Query: 2544 VSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLV 2603
                   +      + +P +      E P PP          T  P+T  + +  +    
Sbjct: 1865 FCLNYEINVQCCECVTQPTTMTTTTTENPTPP----------TTTPITTTTTVTPTPTPT 1914

Query: 2604 AADKEKVAPV-----IAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLV 2658
                    P+     + P  T   ++ P +  +  +  +T       T T   + +T   
Sbjct: 1915 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 1974

Query: 2659 NVSLVPV-NALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGT 2717
             V+  P     + P    +TT  ++  TP              TG     TTP+  T  T
Sbjct: 1975 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTP------------TGTQTPTTTPITTTT-T 2021

Query: 2718 VNAAP---GTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCK 2774
            V   P   GT     + +  T + VT T       +   T  T T T+        T+  
Sbjct: 2022 VTPTPTPTGTQTPTTTPITTTTT-VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2080

Query: 2775 QRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKI 2834
                    +   P   P     P          V  +      + +G +T     I+   
Sbjct: 2081 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP-----TPTGTQTPTTTPITTTT 2135

Query: 2835 SQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYN 2894
            +  P  +       Q+ + + +   +     P   G Q P       T +T V    T  
Sbjct: 2136 TVTPTPTPTGT---QTPTTTPITTTTTVTPTPTPTGTQTPT--TTPITTTTTVTPTPTPT 2190

Query: 2895 ASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIV 2954
             +   ++      +   P P      TP T   T    T  +   P     Q   T  I 
Sbjct: 2191 GTQTPTTTPITTTTTVTPTPTPTGTQTPTT---TPITTTTTVTPTPTPTGTQTPTTTPIT 2247

Query: 2955 TTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPA---LPSKLP-TEVNHVPSGPSIPAD 3010
            TT      P     +T    P    +T+TP   P     P+  P T    V   P+    
Sbjct: 2248 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2307

Query: 3011 RTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISS 3070
            +T +          +P P+  G  +      P++T  T  +T        G   P     
Sbjct: 2308 QTPTTTPITTTTTVTPTPTPTGTQT------PTTTPITTTTTVTPTPTPTGTQTPT---- 2357

Query: 3071 IHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIE 3130
                      P + T TV+ +    G     TPT   IT +       +P     P    
Sbjct: 2358 --------TTPITTTTTVTPTPTPTGT---QTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2406

Query: 3131 VRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYT 3190
            +       TP P P G     +Q P    +     V     P  ++           P T
Sbjct: 2407 ITTTTTV-TPTPTPTG-----TQTPTTTPITTTTTVTPTPTPTGTQT----------PTT 2450

Query: 3191 VPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPV 3250
             P      V P  T    Q      +      +  P   G +   T       T TP P 
Sbjct: 2451 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2510

Query: 3251 PVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGD 3310
            P     P   P        +T TP+      P T P+  T                    
Sbjct: 2511 PTGTQTPTTTPIT--TTTTVTPTPTPTGTQTPTTTPITTT-------------------- 2548

Query: 3311 IRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCP 3370
              T  P    T TQ P  + +   + T T    P P G       P+ +T    P P   
Sbjct: 2549 -TTVTPTPTPTGTQTPTTTPI---TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP--T 2602

Query: 3371 PSQLGQPGQPPSSKMPQV--SQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETG- 3427
            P+    P   P +    V  +    GTQT          P   P    T V      TG 
Sbjct: 2603 PTGTQTPTTTPITTTTTVTPTPTPTGTQT----------PTTTPITTTTTVTPTPTPTGT 2652

Query: 3428 --PTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPS-TPPGLVLPHT 3476
              PT+ P   + ++ P  P    TQT    P+   TT  P+ TP G   P T
Sbjct: 2653 QTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2703



 Score = 76.6 bits (187), Expect = 4e-13
 Identities = 186/954 (19%), Positives = 274/954 (28%), Gaps = 169/954 (17%)

Query: 2542 KYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEV 2601
            K ++  S  +T+ +       +  P    +PP    +  P     +PP+T  +       
Sbjct: 1394 KCITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTT------- 1446

Query: 2602 LVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVS 2661
                     +P I+   T   +  P       S   T   P P T T      T     +
Sbjct: 1447 -TPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSP-PTTTTTTPPPTTTPSPPT 1504

Query: 2662 LVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAA 2721
              P+         S TTL    +TP+ P      P    T P    TTP+     T    
Sbjct: 1505 TTPITP-----PASTTTLPP-TTTPSPPTTTTTTPPPTTT-PSPPTTTPITPPTSTTTLP 1557

Query: 2722 PGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANE 2781
            P T  +       T    T  +   T      T TT T         P+T          
Sbjct: 1558 PTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTT---------T 1608

Query: 2782 NSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPAS 2841
             +   P + P                                T  P       + +PP +
Sbjct: 1609 TTTPPPTTTP-----------------------------SPPTTTPITPPTSTTTLPPTT 1639

Query: 2842 AMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISS 2901
                      + +   P + T S P +  P  P     + T +T   T  T  +SP+ ++
Sbjct: 1640 TP----SPPPTTTTTPPPTTTPSPPTTTTPSPP-----ITTTTTPPPT--TTPSSPITTT 1688

Query: 2902 VKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLA 2961
                  ++  P P   + S+P+T   T    T     P  +       TPS  TT     
Sbjct: 1689 PSPPTTTMTTPSPT-TTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTL 1747

Query: 2962 DPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKL 3021
             P T           +   T TP  P   P          P+ P +P       L + K 
Sbjct: 1748 PPTT----------TSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLDSGKP 1797

Query: 3022 DAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPP 3081
            + H P   G           P   A+  +S  AT               ++P+  +    
Sbjct: 1798 NFHKP---GGDTELIGDVCGPGWAAN--ISCRAT---------------MYPDVPIGQLG 1837

Query: 3082 HSITQTVSLSHLSQGEVRMNTPTLP---SITYSIRPEALHSPRAPLQPQQIEVRAPQRAS 3138
             ++   VS+  + + E +     +P    + Y I  +       P          P   +
Sbjct: 1838 QTVVCDVSVGLICKNEDQKPGGVIPMAFCLNYEINVQCCECVTQPTTMTTTTTENPTPPT 1897

Query: 3139 ----------TPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHP 3188
                      TP P P G     +Q P    +     V     P  ++           P
Sbjct: 1898 TTPITTTTTVTPTPTPTG-----TQTPTTTPITTTTTVTPTPTPTGTQT----------P 1942

Query: 3189 YTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPA 3248
             T P      V P  T    Q      +      +  P   G +   T       T TP 
Sbjct: 1943 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2002

Query: 3249 PVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRY 3308
            P P     P   P        +T TP+      P T P+  T                  
Sbjct: 2003 PTPTGTQTPTTTPIT--TTTTVTPTPTPTGTQTPTTTPITTT------------------ 2042

Query: 3309 GDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPP 3368
                T  P    T TQ P  + +   + T T    P P G       P+ +T    P P 
Sbjct: 2043 ---TTVTPTPTPTGTQTPTTTPI---TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP- 2095

Query: 3369 CPPSQLGQPGQPPSSKMPQV--SQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAET 3426
              P+    P   P +    V  +    GTQT          P   P    T V      T
Sbjct: 2096 -TPTGTQTPTTTPITTTTTVTPTPTPTGTQT----------PTTTPITTTTTVTPTPTPT 2144

Query: 3427 G---PTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPS-TPPGLVLPHT 3476
            G   PT+ P   + ++ P  P    TQT    P+   TT  P+ TP G   P T
Sbjct: 2145 GTQTPTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2197



 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 95/418 (22%), Positives = 125/418 (29%), Gaps = 51/418 (12%)

Query: 3063 PVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNT---PTL---PSITYSIRPEA 3116
            P+ + I++  P  +   PP + T T+  +          T   PT    P IT +  P  
Sbjct: 1391 PMDKCITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPP 1450

Query: 3117 LHSPRAPLQPQQIEVRAPQRASTPQP-APAGVPALASQHPPEEEVHYHLPVARATAPVQS 3175
              +P  P+         P   +TP P      P   +  PP        P    + P  +
Sbjct: 1451 TTTPSPPIST----TTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTT 1506

Query: 3176 EVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAK 3235
             +    S   L P T P        P  T  +            PP +  P  P      
Sbjct: 1507 PITPPASTTTLPPTTTPS-------PPTTTTT-----------TPPPTTTPSPPTTTPIT 1548

Query: 3236 TPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQI 3295
             P +     PT  P P P     P P         T TPS      P  P +  T     
Sbjct: 1549 PPTSTTTLPPTTTPSPPPTTTTTPPP---------TTTPSPPTTTTPSPPTITTTTPPPT 1599

Query: 3296 VHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQ 3355
               S             T  PP     T  P  S+  LP    T    PPP      PP 
Sbjct: 1600 TTPSPPTTTTTTPPPTTTPSPPTTTPIT--PPTSTTTLPP---TTTPSPPPTTTTTPPPT 1654

Query: 3356 PVQSTQPAQ-PAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPE 3414
               S      P+PP   +    P   PSS +         T T       P+ P      
Sbjct: 1655 TTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTT 1714

Query: 3415 PHTQVQRAQAET-----GPTSFPSPVSVSMK--PDLPVSLPTQTAPKQPLFVPTTSGP 3465
            P +    +   T      PT+ PSP + +M   P    S P  T P  P   P T  P
Sbjct: 1715 PSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSP 1772



 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 152/843 (18%), Positives = 257/843 (30%), Gaps = 60/843 (7%)

Query: 2236 PPPYPGESQTDLQPPAGAQAL---QPSEEGMETDEAVSGILETEAATESSRPPVNAPDPS 2292
            P P P  +QT    P          P+  G +T         T   T ++  P   P  +
Sbjct: 3588 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT------TPITTTTTVTPTPTPTGT 3641

Query: 2293 AGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPV 2352
              PT T      ++ T    P   G++    T +        T      +      +   
Sbjct: 3642 QTPTTTPIT---TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3698

Query: 2353 ESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSS 2412
             +  P       ++P     TT            ++ P +T P + T+ ++  P+   + 
Sbjct: 3699 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP-TTTPITTTTTVTPTPTPTGT- 3756

Query: 2413 QEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTL 2472
                   +TPT   +       P P P   +      + +     P   P+    P  T 
Sbjct: 3757 -------QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3809

Query: 2473 PSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSS 2532
             + T      P  +G     + P   T  +T    P    TP+   P  T  +   T + 
Sbjct: 3810 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTVTPTPTP 3868

Query: 2533 TLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTN 2592
            T  +        + T+VT T   T    P +  P        P  +    +  T  P+T 
Sbjct: 3869 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT-PITTTTTVTPTPTPTGTQTPTTTPITT 3927

Query: 2593 NSEIQASEVLVAADKEKVAPV-----IAPKITSVISRMPVSIDLENSQKITLAKPAPQTL 2647
             + +  +            P+     + P  T   ++ P +  +  +  +T       T 
Sbjct: 3928 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3987

Query: 2648 TGLVSALTGLVNVSLVPV-NALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNV 2706
            T   + +T    V+  P     + P    +TT  ++  TP  P          +T    V
Sbjct: 3988 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-PTGTQTPTTTPITTTTTV 4046

Query: 2707 LTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAV 2766
              TP      T    P T     +         T T   +T  +      T T T     
Sbjct: 4047 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 4106

Query: 2767 IAPSTKCKQRASANENSRFHPGSMPV-----IDDRPADAGSGAGLRV---NTSEGVVLLS 2818
               +T      +        P + P+     +   P   G+          T+      +
Sbjct: 4107 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 4166

Query: 2819 YSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPP--SKGPQAPAG 2876
             +G +T     I+   +  P  +    +       S      +T S PP  S  PQ    
Sbjct: 4167 PTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRS 4226

Query: 2877 YANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGI 2936
             ++  T ST +L+       P I       PS     P   S    ++   +      G 
Sbjct: 4227 TSSPLTESTTLLST----LPPAIEMTSTAPPSTPTA-PTTTSGGHTLSPPPSTTTSPPGT 4281

Query: 2937 NTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGST-LTPHHPPALPSKLP 2995
             T      +    TPS V T    A   T    T +  P+ + +T L P+    L   + 
Sbjct: 4282 PTRGTTTGSSSAPTPSTVQTTTTSAWTPT---PTPLSTPSIIRTTGLRPYPSSVLICCVL 4338

Query: 2996 TEVNHVP-----SGPSIPADRTVSHLAAAKLDAHS-PRPSGPGPS-----SFPRASHPSS 3044
             +  + P     +G        V+   +  L+ ++   PS P P+     S P  S PSS
Sbjct: 4339 NDTYYAPGEEVYNGTYGDTCYFVNCSLSCTLEFYNWSCPSTPSPTPTPSKSTPTPSKPSS 4398

Query: 3045 TAS 3047
            T S
Sbjct: 4399 TPS 4401



 Score = 63.9 bits (154), Expect = 3e-09
 Identities = 75/292 (25%), Positives = 92/292 (31%), Gaps = 24/292 (8%)

Query: 3220 PPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQ 3279
            PP +  P  P       P       PT  P P P   P+P P         T TPS    
Sbjct: 1448 PPPTTTPSPPISTTTTPPPTTTPSPPTTTPSP-PTTTPSP-PTTTTTTPPPTTTPSPPTT 1505

Query: 3280 GLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTK- 3338
              P+TPP   T        S             T  PP     T  P  S+  LP  T  
Sbjct: 1506 -TPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPIT--PPTSTTTLPPTTTP 1562

Query: 3339 ----TAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKG 3394
                T    PPP   P  PP     + P       PP+    P    ++  P  +  +  
Sbjct: 1563 SPPPTTTTTPPPTTTP-SPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPP 1621

Query: 3395 TQTGVEQPR----LPAGPANRPPEPHTQVQRAQAETGP----TSFPSP---VSVSMKPDL 3443
            T T +  P     LP  P   P  P T        T P    T+ PSP    + +  P  
Sbjct: 1622 TTTPITPPTSTTTLP--PTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTT 1679

Query: 3444 PVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRP 3495
              S P  T P  P    TT  P+T P   +  T    +    S P  T   P
Sbjct: 1680 TPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTP 1731



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 65/260 (25%), Positives = 80/260 (30%), Gaps = 40/260 (15%)

Query: 3243 PTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGEL 3302
            PT TP+P P       P   P       T  P         +PP+  T            
Sbjct: 1402 PTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTP----SPPITTT------------ 1445

Query: 3303 FQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQP 3362
                      T  PP   T T  P  S+   P  T T +        P   P P  +T  
Sbjct: 1446 ----------TTPPP---TTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTT 1492

Query: 3363 AQPAPPCPPSQLGQPGQPPSSK--MPQVSQEAKGTQTGVEQP--RLPAGPANRPPEPHTQ 3418
              P    P      P  PP+S   +P  +  +  T T    P    P+ P   P  P T 
Sbjct: 1493 TPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTS 1552

Query: 3419 VQRAQAETGPTSFPSP---VSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPH 3475
                     PT+ PSP    + +  P    S PT T P  P    TT  P+T P      
Sbjct: 1553 TTTLP----PTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTT 1608

Query: 3476 TEFQPAPKQDSSPHLTSQRP 3495
            T   P     S P  T   P
Sbjct: 1609 TTTPPPTTTPSPPTTTPITP 1628



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 46/181 (25%), Positives = 59/181 (32%), Gaps = 16/181 (8%)

Query: 3325 FPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQS------TQPAQPAPPCPPSQLGQPG 3378
            +P    +  PS   T    PPP      PP    S      T P     P PP       
Sbjct: 1390 WPMDKCITTPS-PPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTP 1448

Query: 3379 QPPSSKMPQVSQEAKGTQTGVEQP--RLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVS 3436
             P ++  P +S       T    P    P+ P   P  P T          PT+ PSP +
Sbjct: 1449 PPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTT----TTTTPPPTTTPSPPT 1504

Query: 3437 VS--MKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQR 3494
             +    P    +LP  T P  P    TT  P+T P      T   P     + P  T+  
Sbjct: 1505 TTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTT-TPITPPTSTTTLPPTTTPS 1563

Query: 3495 P 3495
            P
Sbjct: 1564 P 1564



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 48/244 (19%), Positives = 71/244 (29%), Gaps = 24/244 (9%)

Query: 1617 PKTPESAPENKDSELKTPPSV---GPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKT 1673
            P  P + P    +   TPP      PP+ T +T  ++ + L  TT          T   T
Sbjct: 1477 PSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPT 1536

Query: 1674 ----------VEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGS 1723
                      + P T +    P + P+P P         PP   P       P+     +
Sbjct: 1537 TTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTP---PPTTTPSPPTTTTPS-PPTIT 1592

Query: 1724 SGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADA 1783
            +   PP     PPT   + +       P P +T P++ P   +          P  T   
Sbjct: 1593 TTTPPPTTTPSPPT--TTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTT 1650

Query: 1784 EPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRK 1843
             P     +     +  P        PP          S  + TP           P T  
Sbjct: 1651 PPPTTTPSPPTTTTPSPPITTTTTPPPTTTP-----SSPITTTPSPPTTTMTTPSPTTTP 1705

Query: 1844 SERI 1847
            S  I
Sbjct: 1706 SSPI 1709



 Score = 43.9 bits (102), Expect = 0.003
 Identities = 43/210 (20%), Positives = 62/210 (29%), Gaps = 9/210 (4%)

Query: 1607 VEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTV-----VTLESAPSALEKTTGDK 1661
            ++K   T + P T  S P    + L    +  PP+ T       T  S P     T    
Sbjct: 1392 MDKCITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPT 1451

Query: 1662 TVEAPLVTEEKTVEPATV-SEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVE 1720
            T  +P ++   T  P T  S      S P   P         PP           P    
Sbjct: 1452 TTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI-TP 1510

Query: 1721 EGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDAT 1780
              S+   PP     PPT   + +       P P +T P++ P   +          P  T
Sbjct: 1511 PASTTTLPPTTTPSPPT--TTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTT 1568

Query: 1781 ADAEPDANQKAEAAPESQPPASEDLEVDPP 1810
                P     +     +  P +      PP
Sbjct: 1569 TTTPPPTTTPSPPTTTTPSPPTITTTTPPP 1598



 Score = 36.6 bits (83), Expect = 0.47
 Identities = 33/155 (21%), Positives = 61/155 (39%), Gaps = 11/155 (7%)

Query: 1613 TENHPKTPESAPENKDSELK---TPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVT 1669
            T    +TP + P    + +    TP     P+ T +T  +  +     TG +T     +T
Sbjct: 4120 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 4179

Query: 1670 EEKTVEPATV--SEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSS--G 1725
               TV P       +  P +  + AP+ +L   + PP +   + +    + + E ++   
Sbjct: 4180 TTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLS 4239

Query: 1726 DQPPYLD----AKPPTPGASFSQAESNVDPEPDST 1756
              PP ++    A P TP A  + +  +    P ST
Sbjct: 4240 TLPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPST 4274



 Score = 34.7 bits (78), Expect = 1.8
 Identities = 32/129 (24%), Positives = 45/129 (34%), Gaps = 19/129 (14%)

Query: 3368 PCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETG 3427
            P PP+    P    ++ +P  +  +  T T    P     P   P  P T          
Sbjct: 1399 PSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPP-----PTTTPSPPITTTTTPP---- 1449

Query: 3428 PTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSS 3487
            PT+ PSP         P+S  T   P      PTT+ PS P     P T     P   ++
Sbjct: 1450 PTTTPSP---------PISTTTTPPPTTTPSPPTTT-PSPPTTTPSPPTTTTTTPPPTTT 1499

Query: 3488 PHLTSQRPV 3496
            P   +  P+
Sbjct: 1500 PSPPTTTPI 1508



 Score = 34.7 bits (78), Expect = 1.8
 Identities = 46/229 (20%), Positives = 59/229 (25%), Gaps = 24/229 (10%)

Query: 1620 PESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATV 1679
            P + P    S   TPP    PS    T    PS    T    T          T  P T 
Sbjct: 1450 PTTTPSPPISTTTTPPPTTTPSPPTTT----PSPPTTTPSPPTTTTTTPPPTTTPSPPTT 1505

Query: 1680 SEEAKPAS----EPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKP 1735
            +    PAS     P   P         PP           P      ++   P    + P
Sbjct: 1506 TPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPP 1565

Query: 1736 PTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAP 1795
            PT         +   P P +T   S P   +          P  T    P         P
Sbjct: 1566 PT---------TTTTPPPTTTP--SPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPP 1614

Query: 1796 ESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKS 1844
             + P       + PP +     P     + TP      +    P T  S
Sbjct: 1615 TTTPSPPTTTPITPPTSTTTLPP-----TTTPSPPPTTTTTPPPTTTPS 1658


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score =  123 bits (309), Expect = 3e-27
 Identities = 143/601 (23%), Positives = 236/601 (39%), Gaps = 88/601 (14%)

Query: 1589 ELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLE 1648
            ++T    +E+EK+ K +E +++E  E      E   E  + E K+PP+    S      E
Sbjct: 465  QVTEEVTEEEEKEAKEEEGKEEEGGE------EEEAEGGEEETKSPPAEEAASP-----E 513

Query: 1649 SAPSALEKTTGDKTVEAPLVTEEKTVEPATVS--EEAK-PASEPAPAPVEQLEQVDLPPG 1705
                +  K       EA    +E+   PA V   E+AK PA E A +P         P  
Sbjct: 514  KEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP---------PEA 564

Query: 1706 ADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPE----PDSTQPLSK 1761
              P+KE A  PA V+       P   +AK P    S  +A+S V  E     ++  P+ +
Sbjct: 565  KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624

Query: 1762 PAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKS 1821
             A+   E   P+  K     +A+     K+    E++ P     +   PV A+ K P K 
Sbjct: 625  EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE----KAKSPVKAEAKSPEK- 679

Query: 1822 KRSKTPVQAAAVSIVEKPVTRKSERIDREKLK-----------RSNSPRGEAQKLLE--- 1867
              +K+PV+A A S  +     K E    EK K           ++ SP  E  K  E   
Sbjct: 680  --AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAK 737

Query: 1868 --LKMEAEKITRTAS--KNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEP 1923
              +K EA+   +  S  K    D++ PE   P     R       A     + +SPVKE 
Sbjct: 738  SPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP-----ADKFPEKAKSPVKEE 792

Query: 1924 VEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRS 1983
            V+ P   +  L+ + +        P +  P K   ++  +EE + +E  +  +PP+    
Sbjct: 793  VKSPEKAKSPLKEDAK-------APEKEIPKKEEVKSPVKEEEKPQE-VKVKEPPKKAEE 844

Query: 1984 PRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKR 2043
             ++  T      +  K +  PK +A +P+   +  P +       +PK ++ EA  E+  
Sbjct: 845  EKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAV------EKPKESKVEAKKEEAE 898

Query: 2044 DRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPR 2103
            D+K   T   P + AP +V  K+ A  K       +  +   A + S   +  +AA   +
Sbjct: 899  DKKKVPT---PEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKK 955

Query: 2104 GAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEAT 2163
                              EK++ P+++    ++ K D     KEP K     +  S    
Sbjct: 956  D--------------TKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD 1001

Query: 2164 Q 2164
            Q
Sbjct: 1002 Q 1002



 Score =  107 bits (267), Expect = 2e-22
 Identities = 137/586 (23%), Positives = 222/586 (37%), Gaps = 49/586 (8%)

Query: 1640 PSVTV---VTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQ 1696
            PSV+    V  E     +EK+  + TV     TEE  V      EE K A E      E 
Sbjct: 430  PSVSTHIKVKSEEKIKVVEKSEKE-TVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEG 488

Query: 1697 LEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDST 1756
             E+ +   G +  K      A   E      P   +AK P    S  + E+    E  S 
Sbjct: 489  GEEEEAEGGEEETKSPPAEEAASPE-KEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP 547

Query: 1757 QPLSKPAQKS----EEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVA 1812
            +    PA++      EA  P+ E+  + A+ +     K+ A  E++ PA    E   P  
Sbjct: 548  EKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA----EAKSPEK 603

Query: 1813 AKDKKPNKSK---RSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELK 1869
            AK     ++K    +K+PV+  A S  E     K++   +E+ K   SP    +K    +
Sbjct: 604  AKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAK---SP----EKAKSPE 656

Query: 1870 MEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRV 1929
             E  K    A     A+ + PE +    +   ++           + +SPVKE  + P  
Sbjct: 657  KEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKS---------PEKAKSPVKEEAKSPEK 707

Query: 1930 TRKRLERELQEAAAVPTTPRRGRPP-KTRRRADEEEENEAKEPAETLKPPEGWRSPRSQK 1988
             +  ++ E +       +P + + P K   +  E+ ++  KE A   K PE  +SP   K
Sbjct: 708  AKSPVKEEAK-------SPEKAKSPVKEEAKTPEKAKSPVKEEA---KSPEKAKSPEKAK 757

Query: 1989 TAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDA 2048
            T     P+    K   K +A  P        +  VKE    P+ A+     + K   K+ 
Sbjct: 758  TLDVKSPE---AKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKE- 813

Query: 2049 GTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQ 2108
               K     +PV+  E+KP   K  +  +        A  K+   K+     +P+  A +
Sbjct: 814  -IPKKEEVKSPVK-EEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPK 871

Query: 2109 AGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQ 2168
                E    AV   K    + +   +   K  P    + P K +V       E T++AK+
Sbjct: 872  PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK 931

Query: 2169 MELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETE 2214
               +   +  +K AE   +A  K D  E  A +  +KP  +A   E
Sbjct: 932  EPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE 977



 Score =  102 bits (255), Expect = 5e-21
 Identities = 127/531 (23%), Positives = 203/531 (38%), Gaps = 54/531 (10%)

Query: 1912 GDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEP 1971
            G+ E +SP   P E+     K  +  ++E A  P   +     + +  A+ +   +AK P
Sbjct: 497  GEEETKSP---PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSP 553

Query: 1972 A--ETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRP-EATTEVGPQIGVKESSM 2028
            A  E   PPE     + +  +       +K K+  K +A  P EA +    +  VKE + 
Sbjct: 554  AKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK 613

Query: 2029 EPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVD 2088
             P     EA S  K + K     K+P E A     E+  +PEK    ++  +++   A  
Sbjct: 614  SPA----EAKSPVKEEAKSPAEVKSP-EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS 668

Query: 2089 K-SASLKNVDAAVSPRGAAAQAGERESGVV---AVSPEKSESPQKEDGLSSQLKSDPVDP 2144
               A  K+ + A SP  A A++ E+    V   A SPEK++SP KE+  S +    PV  
Sbjct: 669  PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728

Query: 2145 D-KEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDR 2203
            + K PEK   + S    EA    K    E+A     K  EA   A  +A +P    PE  
Sbjct: 729  EAKTPEK---AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785

Query: 2204 DKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGM 2263
              P  +  ++   A    +  D     +  P         + + +P        P +   
Sbjct: 786  KSPVKEEVKSPEKAK-SPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEE 844

Query: 2264 ETDEAVSGILETEAATESSRPPVNAPDPSAG---------PTDTK-EARGNSSETSHSVP 2313
            E   A     E + + +   P   AP P            P ++K EA+   +E    VP
Sbjct: 845  EKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP 904

Query: 2314 EAKGSKEVEVTLVRKDKGRQKTTRSRRK----------RNTNKKVVAPVESHVPESNQAQ 2363
              +     +V +    K ++KT  ++++          +   KK  AP +    E    +
Sbjct: 905  TPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKK 964

Query: 2364 GESPAANEG-------TTVQHPEAPQEEKQSEKPHST------PPQSCTSD 2401
             E     E        T  + P  P+ EK +EK  ST      PP+  T D
Sbjct: 965  PEEKPKTEAKAKEDDKTLSKEPSKPKAEK-AEKSSSTDQKDSKPPEKATED 1014



 Score = 93.6 bits (231), Expect = 3e-18
 Identities = 122/558 (21%), Positives = 205/558 (36%), Gaps = 61/558 (10%)

Query: 2024 KESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETA---------PVEVVEKKPAPEKNSK 2074
            ++ + E +  EEE G E++ +  +  T   P E A         PV+   K PA  K+ +
Sbjct: 475  EKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE 534

Query: 2075 SKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLS 2134
             +  +S     + +K+ S    +A   P   + +  E +S     SPEK++SP KE+  S
Sbjct: 535  KEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 594

Query: 2135 SQLKSDP---VDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYK 2191
                  P     P KE  K    A  P  E  +   +++  +  +   K    S   A  
Sbjct: 595  PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS 654

Query: 2192 ADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPA 2251
             +  E  +PE    P    +++                PE   +P     +S    + P 
Sbjct: 655  PEKEEAKSPEKAKSPVKAEAKS----------------PEKAKSPVKAEAKSPEKAKSPV 698

Query: 2252 GAQALQPSEEGMETDEAVSGILETEAATESSRPPV--NAPDPSAGPTDTKEARGNSSETS 2309
                    EE    ++A S + E   + E ++ PV   A  P    +  KE    S E +
Sbjct: 699  -------KEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE-EAKSPEKA 750

Query: 2310 HSVPEAK--GSKEVEVTLVRKDKGRQKTTR--SRRKRNTNKKVVAPVESHVPESNQAQGE 2365
             S  +AK    K  E     K++ R    +   + K    ++V +P ++  P    A+  
Sbjct: 751  KSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAP 810

Query: 2366 SPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPST-ENSSQEISVEERTPTK 2424
                 +   V+ P   +EEK  E     PP+    +  K P+T +   ++ S +E  P K
Sbjct: 811  EKEIPKKEEVKSP-VKEEEKPQEVKVKEPPKKAEEE--KAPATPKTEEKKDSKKEEAPKK 867

Query: 2425 ASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSV--------- 2475
             +  P +    +PA V++  +++         D    P+ P    P    V         
Sbjct: 868  EAPKPKVEEKKEPA-VEKPKESKVEAKKEEAEDKKKVPT-PEKEAPAKVEVKEDAKPKEK 925

Query: 2476 -TAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTL 2534
               AK  P  A    P  S P +  E    +++ + +    P   P T+A        TL
Sbjct: 926  TEVAKKEPDDAKAKEP--SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK-AKEDDKTL 982

Query: 2535 RKILMDPKYVSATSVTST 2552
             K    PK   A   +ST
Sbjct: 983  SKEPSKPKAEKAEKSSST 1000



 Score = 92.4 bits (228), Expect = 7e-18
 Identities = 140/603 (23%), Positives = 241/603 (39%), Gaps = 68/603 (11%)

Query: 1920 VKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPE 1979
            V+E  E+ +VT +  E E +EA                 + +E +E E  E  E     E
Sbjct: 457  VEEQTEETQVTEEVTEEEEKEA-----------------KEEEGKEEEGGEEEEAEGGEE 499

Query: 1980 GWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGS 2039
              +SP +++ A+   P+ K+ K+  K +A  P       P+    +S  E K+ E+ A S
Sbjct: 500  ETKSPPAEEAAS---PE-KEAKSPVKEEAKSPAEAKS--PEKEEAKSPAEVKSPEK-AKS 552

Query: 2040 EQKRDRKDAGTDKNPPET---APVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNV 2096
              K + K     K+P +    +P EV  K P   K+   +  +S     + +K+ S    
Sbjct: 553  PAKEEAKSPPEAKSPEKEEAKSPAEV--KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610

Query: 2097 DAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLS-SQLKSDPVDPDKEPE--KEDV 2153
            +A       +    E +S     SPEK++SP KE+  S  + KS   +  K PE  K  V
Sbjct: 611  EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV 670

Query: 2154 SASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAP---EGLAPEDRDKPAHQA 2210
             A   SPE  +   + E  ++ E      +  A +  KA +P   E  +PE    P  + 
Sbjct: 671  KAEAKSPEKAKSPVKAE-AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 729

Query: 2211 SETELAAAIGSIINDISGEPENFPAPPPYP--GESQTDLQPPAGAQALQPSEEGMETDEA 2268
            ++T   A   S + + +  PE   +P           + + PA  +A  P+++  E  +A
Sbjct: 730  AKTPEKAK--SPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPE--KA 785

Query: 2269 VSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRK 2328
             S + E   + E ++ P+   D  A   +  +      E    V E +  +EV+V    K
Sbjct: 786  KSPVKEEVKSPEKAKSPLK-EDAKAPEKEIPK----KEEVKSPVKEEEKPQEVKVKEPPK 840

Query: 2329 DKGRQK--TTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQ 2386
                +K   T    ++  +KK  AP +   P+    + + PA  E       EA +EE +
Sbjct: 841  KAEEEKAPATPKTEEKKDSKKEEAP-KKEAPKPKVEEKKEPAV-EKPKESKVEAKKEEAE 898

Query: 2387 SEKPHSTPPQSCTSDLS-KIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEE-- 2443
             +K   TP +   + +  K  +      E++ +E    KA  P       + AP  ++  
Sbjct: 899  DKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTK 958

Query: 2444 ------PQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTK 2497
                  P+ + +  +  + D  T   +PS P         A+ +   +S       PP K
Sbjct: 959  EEKAKKPEEKPKTEAKAKEDDKTLSKEPSKP--------KAEKAEKSSSTDQKDSKPPEK 1010

Query: 2498 VTE 2500
             TE
Sbjct: 1011 ATE 1013



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 115/567 (20%), Positives = 225/567 (39%), Gaps = 65/567 (11%)

Query: 770  SPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVH 829
            S  + + ++KS  E     E+T++ +  +    E E+    +E  E++  ++++ +G   
Sbjct: 440  SEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEE 499

Query: 830  SPSSQSSETDQENERE-QSPEKPRSCNKLSREKADKEGIAKNRLEL-MPCVVLTRVKEKE 887
               S  +E     E+E +SP K  + +    +  +KE  AK+  E+  P    +  KE+ 
Sbjct: 500  ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEE-AKSPAEVKSPEKAKSPAKEEA 558

Query: 888  GKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSS 947
                +    EK +AK   + VKS    +K +    E AKS        + K P ++   S
Sbjct: 559  KSPPEAKSPEKEEAKSPAE-VKS---PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614

Query: 948  HVEV---VEKEGRLKAR-------KHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEK 997
              E    V++E +  A        K    E+      A   EK EA+    A S +KAE 
Sbjct: 615  PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674

Query: 998  QKPEVKKS-------------SPEMEDARVLSKKQPDVSSREVILLREGEAERKPVRKEI 1044
            + PE  KS             SP  E+A+   K +  V        +  E  + PV++E 
Sbjct: 675  KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE----AKSPEKAKSPVKEEA 730

Query: 1045 LKRESKKIKLDR----LNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVENQE 1100
               E  K  +           SP+  + L   S  + +    + ++   +   ++    +
Sbjct: 731  KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVK 790

Query: 1101 VQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYC-----------SLRDETPERKSGQEK 1149
             + K P  +K  LK+    D + PE+E  +K               ++ + P +K+ +EK
Sbjct: 791  EEVKSPEKAKSPLKE----DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK 846

Query: 1150 SHSV-NTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLV 1208
            + +   TEEK     +          +   K++  +E  K  K  + K++ ++ ++    
Sbjct: 847  APATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTP 906

Query: 1209 HEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSPSVRHGS 1268
             +      +V +D+ P +K  +         K+E +   +++ S+ +E+   +P  +   
Sbjct: 907  EKEAPAKVEVKEDAKPKEKTEV--------AKKEPDDAKAKEPSKPAEKKEAAPEKKDTK 958

Query: 1269 FHEDEDPIGSPRLLSVKGSPKVDEKVL 1295
              + + P   P+    +   K D+K L
Sbjct: 959  EEKAKKPEEKPK---TEAKAKEDDKTL 982



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 122/622 (19%), Positives = 230/622 (36%), Gaps = 87/622 (13%)

Query: 2012 EATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPV-EVVEKKPAPE 2070
            E  TE   Q+  + + +E   + +++   Q+ + +D    ++  + A   E +++  A  
Sbjct: 316  EEITEYRRQLQARTTELEALKSTKDSLERQRSELED----RHQADIASYQEAIQQLDAEL 371

Query: 2071 KNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAA----AQAGERESGVVAVSPEKSES 2126
            +N+K +          + +   L NV  A+    AA     +  E   G   +     E 
Sbjct: 372  RNTKWEMAAQ------LREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEG 425

Query: 2127 PQKEDGLSSQLK---SDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAE 2183
              K   +S+ +K    + +   ++ EKE V     + E TQ+ +++  E+  E  AK  E
Sbjct: 426  LPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEE-TQVTEEVTEEEEKE--AKEEE 482

Query: 2184 ASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGES 2243
                   + +  EG   E +  PA +A+  E  A   S + + +  P    +P     +S
Sbjct: 483  GKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAK--SPVKEEAKSPAEAKSPEKEEAKS 540

Query: 2244 QTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARG 2303
              +++ P  A++    EE     EA S         E ++ P     P       ++A+ 
Sbjct: 541  PAEVKSPEKAKS-PAKEEAKSPPEAKS------PEKEEAKSPAEVKSP-------EKAKS 586

Query: 2304 NSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQ 2363
             + E + S  EAK  ++                    K    ++  +P E+  P   +A+
Sbjct: 587  PAKEEAKSPAEAKSPEKA-------------------KSPVKEEAKSPAEAKSPVKEEAK 627

Query: 2364 G----ESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDL-SKIPSTENSSQEISVE 2418
                 +SP   +  T +  ++P++ K  EK  +  P+   S + ++  S E +   +  E
Sbjct: 628  SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687

Query: 2419 ERTPTKASVPPD---LPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSV 2475
             ++P KA  P       P    +PV EE ++  +  S ++ +  TP    S P+    + 
Sbjct: 688  AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKS-PVKE-EAK 745

Query: 2476 TAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLR 2535
            +  K   P  +  +  +SP  K       +EE R+ +   P         +V +      
Sbjct: 746  SPEKAKSPEKAKTLDVKSPEAKTPA----KEEARSPADKFPEKAKSPVKEEVKSPEKAKS 801

Query: 2536 KILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSE 2595
             +  D K                  P    P   E   P  + +KP E K   P     E
Sbjct: 802  PLKEDAK-----------------APEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEE 844

Query: 2596 IQASEVLVAADKEKVAPVIAPK 2617
             +A       +K+      APK
Sbjct: 845  EKAPATPKTEEKKDSKKEEAPK 866



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 74/355 (20%), Positives = 141/355 (39%), Gaps = 21/355 (5%)

Query: 701  ERERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSS 760
            E+E  +   ++      E +  E+++SPV     +SP  + S  +      E+       
Sbjct: 656  EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA-KSPEKAKSPVKEEAKSPEKAKSPVKE 714

Query: 761  DRSGSCSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTD 820
            +      + SP + E     + +   K E    E+   PE+         K    K    
Sbjct: 715  EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKA--------KTLDVKSPEA 766

Query: 821  KQKRKGKVHSPSSQSSETDQENEREQ--SPEKPRSCNKLSREKADKEGIAKNRLELMPCV 878
            K   K +  SP+ +  E  +   +E+  SPEK +S  K   +  +KE I K      P  
Sbjct: 767  KTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKE-IPKKEEVKSP-- 823

Query: 879  VLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSAL--DQKLQVSQTEPAKSDLSKLESVR 936
               + +EK  +V    P +K + +    T K+      +K +  + E  K  + + +   
Sbjct: 824  --VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPA 881

Query: 937  MKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAE 996
            ++ PKE  + +  E  E + ++   +   P +      A   EK E  K+   D+  K  
Sbjct: 882  VEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEP 941

Query: 997  KQKPEVKKSSPEMEDARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKK 1051
             +  E K+++PE +D +    K+P+   +     +E +   K + KE  K +++K
Sbjct: 942  SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD---KTLSKEPSKPKAEK 993



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 147/779 (18%), Positives = 291/779 (37%), Gaps = 109/779 (13%)

Query: 901  AKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKG---------LSSHVEV 951
            AK++ D ++S+  +      Q +   ++L  L+S +  + +++          ++S+ E 
Sbjct: 304  AKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEA 363

Query: 952  VEK-EGRLKARK-----HLKPEQPADGVS-AVDLEKLEARKRR--------FADSNLKAE 996
            +++ +  L+  K      L+  Q    V  A+D+E    RK          F        
Sbjct: 364  IQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLP 423

Query: 997  KQKPEVKKSSPEMEDARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDR 1056
            +  P++   S  ++       K  + S +E +++ E + E   V +E+ + E K+ K   
Sbjct: 424  EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEE-QTEETQVTEEVTEEEEKEAK--- 479

Query: 1057 LNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQL 1116
                      +E      G     +   +        E   + E ++K P+  + +    
Sbjct: 480  ----------EEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAK---- 525

Query: 1117 QVLDDQGPEREDVRKNY---CSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQM 1173
               + + PE+E+ +         + ++P ++  +    + + E++        +S  K  
Sbjct: 526  SPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAK 585

Query: 1174 EQSRRKQQMEMEIAKSEKFGSPKKDVDEY--ERRSLVHEVGKPPQDVTDDSPPSKKKRMD 1231
              ++ + +   E    EK  SP K+  +   E +S V E  K P +V     P K K   
Sbjct: 586  SPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKS---PEKAKSPT 642

Query: 1232 HVDFDICTKRERNYRSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPKVD 1291
              +       E+     ++ ++  E+          S  + + P+ +      K    V 
Sbjct: 643  KEE---AKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVK 699

Query: 1292 E--KVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAG 1349
            E  K    +   V+EE+       S  +E+     K K  V   E+  +   ++  + A 
Sbjct: 700  EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPV--KEEAKSPEKAKSPEKAK 757

Query: 1350 RFDVSFPNSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLR 1409
              DV  P +         RS  D  P +  S   E  E KS     S L E ++      
Sbjct: 758  TLDVKSPEAKTPAKE-EARSPADKFPEKAKSPVKE--EVKSPEKAKSPLKEDAKAP---- 810

Query: 1410 DREDKLRERDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDS 1469
              E ++ +++E  S   E  K       K   P  KA  E+A +   + E+         
Sbjct: 811  --EKEIPKKEEVKSPVKEEEKPQEV---KVKEPPKKAEEEKAPATPKTEEK--------- 856

Query: 1470 RFANFRNNKDKEKVDSAPRPIPSWYMKKKK---IRTDSEGKMDDKKEDHKEEEQERQELF 1526
                    KD +K ++  +  P   +++KK   +    E K++ KKE   E E +++   
Sbjct: 857  --------KDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE---EAEDKKKVPT 905

Query: 1527 ASRFLHSSI-FEQDSKRLQHLERKEEDSDFISGRIYGK--QTSEGANSTTDSIQEPVVLF 1583
              +   + +  ++D+K  +  E  +++ D    +   K  +  E A    D+ +E     
Sbjct: 906  PEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA--- 962

Query: 1584 HSRFMELTRMQQKEKEKDQ-------KPK--EVEKQEDTENHP-KTPESAPENKDSELK 1632
              +  E  + + K KE D+       KPK  + EK   T+    K PE A E+K ++ K
Sbjct: 963  -KKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020



 Score = 47.0 bits (110), Expect = 3e-04
 Identities = 78/370 (21%), Positives = 127/370 (34%), Gaps = 44/370 (11%)

Query: 3114 PEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPV---ARAT 3170
            PE   SP         E ++P++A +P    A  PA A + P +EE      V    +A 
Sbjct: 581  PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA-KSPVKEEAKSPAEVKSPEKAK 639

Query: 3171 APVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKV----PPASKAP 3226
            +P + E      E    P              V A ++ P  A   VK     P  +K+P
Sbjct: 640  SPTKEE--AKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 697

Query: 3227 -----------QQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPS 3275
                       + P KE AK+P+   +P    A  P     P    A   E         
Sbjct: 698  VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPE----KAKSP 753

Query: 3276 NQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPS 3335
             + + L +  P   T   +   S  + F E     ++           + P  +   L  
Sbjct: 754  EKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVK--------EEVKSPEKAKSPLKE 805

Query: 3336 RTKTAAQGPPPEGEPLQPPQPVQSTQPAQ-PAPPCPPSQLGQPGQPPSSKMPQVSQE--- 3391
              K   +  P + E   P +  +  Q  +   PP    +   P  P + +     +E   
Sbjct: 806  DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAP 865

Query: 3392 -AKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETG---PT-SFPSPVSVSMKPDLPVS 3446
              +  +  VE+ + PA    +P E   + ++ +AE     PT    +P  V +K D    
Sbjct: 866  KKEAPKPKVEEKKEPA--VEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPK 923

Query: 3447 LPTQTAPKQP 3456
              T+ A K+P
Sbjct: 924  EKTEVAKKEP 933



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 26/236 (11%)

Query: 704  RERERFESDRDRDHERRPI-ERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDR 762
            +E  R  +D+  +  + P+ E  +SP   + P    A   + E +P   E +   +  ++
Sbjct: 771  KEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKE-IPKKEEVKSPVKEEEK 829

Query: 763  SGSCSSLSPPRYEKLDKSRL------ERYTKNEKTDKERTFDPERVERERRLIRKEKVEK 816
                    PP+  + +K+        ++ +K E+  K+    P+  E++   + K K  K
Sbjct: 830  PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889

Query: 817  DKTDKQKR--KGKVHSPSSQSSETDQENEREQSPEKPRSCNKLSRE-KADKEGIAKNRLE 873
             +  K++   K KV +P  ++    +  E  +  EK     K   + KA +      + E
Sbjct: 890  VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKE 949

Query: 874  LMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTV-------------KSSALDQK 916
              P    T  KE++ K  +  P  + KAK D+ T+             KSS+ DQK
Sbjct: 950  AAPEKKDT--KEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQK 1003



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 68/355 (19%), Positives = 121/355 (34%), Gaps = 24/355 (6%)

Query: 3114 PEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPV 3173
            P    SP         EV++P++A +P    A  P  A + P +EE       A   +P 
Sbjct: 527  PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA-KSPEKEEAK---SPAEVKSPE 582

Query: 3174 QSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQ---PG 3230
            +++    +          P   +  V     + +E         K P   K+P++   P 
Sbjct: 583  KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPT 642

Query: 3231 KEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVT 3290
            KE AK+P+   +P    A  P     P  A A   E      +P       P      V 
Sbjct: 643  KEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK---AKSPVKAEAKSPEKAKSPVK 699

Query: 3291 HGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPP---- 3346
               +    +    +E      +   P  +   T   A S V   +++   A+ P      
Sbjct: 700  EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL 759

Query: 3347 --EGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGV---EQ 3401
              +    + P   ++  PA   P    S + +  + P      + ++AK  +  +   E+
Sbjct: 760  DVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE 819

Query: 3402 PRLPAGPANRPPEPHTQ--VQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPK 3454
             + P     +P E   +   ++A+ E  P    +P +   K       P + APK
Sbjct: 820  VKSPVKEEEKPQEVKVKEPPKKAEEEKAPA---TPKTEEKKDSKKEEAPKKEAPK 871



 Score = 40.0 bits (92), Expect = 0.043
 Identities = 82/413 (19%), Positives = 142/413 (34%), Gaps = 48/413 (11%)

Query: 2489 IPHQSPPTKVTEWITRQEEPRA--------------------QSTPSPALPPDTKASDVD 2528
            +  Q+  T+VTE +T +EE  A                    + T SP  P +  AS   
Sbjct: 457  VEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP--PAEEAASPEK 514

Query: 2529 TSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSA-APCLHEAPPPPVDSKKPLEEKTA 2587
             + S +++    P    +           +  P  A +P   EA  PP ++K P +E+  
Sbjct: 515  EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPP-EAKSPEKEEAK 573

Query: 2588 PPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTL 2647
             P    +E+++ E   +  KE+       K +   ++ PV    E ++    AK   +  
Sbjct: 574  SP----AEVKSPEKAKSPAKEEAKSPAEAK-SPEKAKSPVK---EEAKSPAEAKSPVKEE 625

Query: 2648 TGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVL 2707
                + +              K P K      KS     A      K PV          
Sbjct: 626  AKSPAEVKSPEKAKSPTKEEAKSPEKA-----KSPEKEEAKSPEKAKSPVKAEAKSPEKA 680

Query: 2708 TTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVI 2767
             +PV A   +   A   V   A +     S V   A +   A   V     T   A + +
Sbjct: 681  KSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPV 740

Query: 2768 APSTKCKQRASANENSRFHPGSMPVIDDRPA--DAGSGAGLRVNTSEGVVLLSYSGQKTE 2825
                K  ++A + E ++      P     PA  +A S A      ++  V      ++ +
Sbjct: 741  KEEAKSPEKAKSPEKAKTLDVKSPEA-KTPAKEEARSPADKFPEKAKSPV-----KEEVK 794

Query: 2826 GPQRISAKISQIPPASAMDIEFQQSVS---KSQVKPDSVTASQPPSKGPQAPA 2875
             P++  + + +   A   +I  ++ V    K + KP  V   +PP K  +  A
Sbjct: 795  SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA 847



 Score = 38.9 bits (89), Expect = 0.095
 Identities = 58/303 (19%), Positives = 104/303 (34%), Gaps = 29/303 (9%)

Query: 2335 TTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTP 2394
            +T  + K     KVV   E       +   E+    E T  +  EA +EE + E+     
Sbjct: 433  STHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEE 492

Query: 2395 PQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSII 2454
                  + +K P  E ++                   P     +PV EE ++     S  
Sbjct: 493  EAEGGEEETKSPPAEEAAS------------------PEKEAKSPVKEEAKSPAEAKSPE 534

Query: 2455 ESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTP 2514
            + +  +P    S      P+   AK SPP A      ++      +   + + P  +   
Sbjct: 535  KEEAKSPAEVKSPEKAKSPAKEEAK-SPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593

Query: 2515 SPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPP 2574
            SPA     +A   + + S +++    P    +           +  P  A     E    
Sbjct: 594  SPA-----EAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKS 648

Query: 2575 PVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKV-APVIAPKITSVISRMPVSIDLEN 2633
            P  +K P +E+   P    S ++A     A   EK  +PV A   +   ++ PV  + ++
Sbjct: 649  PEKAKSPEKEEAKSPEKAKSPVKAE----AKSPEKAKSPVKAEAKSPEKAKSPVKEEAKS 704

Query: 2634 SQK 2636
             +K
Sbjct: 705  PEK 707



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 73/394 (18%), Positives = 128/394 (32%), Gaps = 44/394 (11%)

Query: 3106 PSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLP 3165
            P    S   E   SP     P + E ++P++A +P  A A  P  A + P +EE      
Sbjct: 649  PEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKA-KSPVKEEAK---S 704

Query: 3166 VARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKA 3225
              +A +PV+ E               P   +  V        +         K P  +K+
Sbjct: 705  PEKAKSPVKEEA------------KSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKS 752

Query: 3226 PQQPGKEAAKTPDAKAAPTPTPAPVPVPVP---LPAPAPAPHGEARILTVTPSNQLQGLP 3282
            P     E AKT D K+    TPA      P    P  A +P  E         + L+   
Sbjct: 753  P-----EKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDA 807

Query: 3283 LTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQ 3342
              P   +    ++      + +E +  +++   PP +    + PA        +T+    
Sbjct: 808  KAPEKEIPKKEEV---KSPVKEEEKPQEVKVKEPPKKAEEEKAPAT------PKTEEKKD 858

Query: 3343 GPPPEGEPLQPPQP--VQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVE 3400
                E    + P+P   +  +PA   P     +  +       K+P   +EA       E
Sbjct: 859  SKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918

Query: 3401 QPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVP 3460
              +         P+  T+V + + +      PS  +   +         +   K+P   P
Sbjct: 919  DAK---------PKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKP 969

Query: 3461 TTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQR 3494
             T   +      L     +P  ++      T Q+
Sbjct: 970  KTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQK 1003



 Score = 37.0 bits (84), Expect = 0.36
 Identities = 62/325 (19%), Positives = 104/325 (32%), Gaps = 16/325 (4%)

Query: 3135 QRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRD 3194
            +   +P    A  P   ++ P +EE       A A +P + E               P  
Sbjct: 499  EETKSPPAEEAASPEKEAKSPVKEEAK---SPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555

Query: 3195 VRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPV 3254
                  P   +  ++   +   VK P  +K+P    KE AK+P    +P    +PV    
Sbjct: 556  EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSP---AKEEAKSPAEAKSPEKAKSPVKEEA 612

Query: 3255 PLPAPAPAP-HGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRT 3313
              PA A +P   EA+      S +    P           +    +    +E      + 
Sbjct: 613  KSPAEAKSPVKEEAKSPAEVKSPEKAKSP------TKEEAKSPEKAKSPEKEEAKSPEKA 666

Query: 3314 YHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQ 3373
              P      +   A S V   +++   A+ P  E E   P +     +    +P    S 
Sbjct: 667  KSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKE-EAKSPEKAKSPVKEEAKSPEKAKSP 725

Query: 3374 LGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRP--PEPHTQVQRAQAETGPTSF 3431
            + +  + P      V +EAK  +      +        P    P  +  R+ A+  P   
Sbjct: 726  VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785

Query: 3432 PSPVSVSMKPDLPVSLPTQTAPKQP 3456
             SPV   +K       P +   K P
Sbjct: 786  KSPVKEEVKSPEKAKSPLKEDAKAP 810



 Score = 32.3 bits (72), Expect = 8.9
 Identities = 35/189 (18%), Positives = 79/189 (41%), Gaps = 22/189 (11%)

Query: 150 GHHERGTGGFDRTRHYDQDYYRDPRERT---LQHGLYYASRSRSPNRFDAHDPRYEPRAR 206
           G  E   GG + T+    +    P +     ++      + ++SP + +A  P  E ++ 
Sbjct: 489 GEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA-EVKSP 547

Query: 207 EQFTLPSVVHRDIYRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPT 266
           E+   P+       +++       + PE+      ++SP    +  +SP++  S A    
Sbjct: 548 EKAKSPA-------KEEAKSPPEAKSPEKE----EAKSP----AEVKSPEKAKSPAKEEA 592

Query: 267 RSPSGSGSRSRSSS---SDSISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLL 323
           +SP+ + S  ++ S    ++ S + + S    ++ S +   SP ++       A + +  
Sbjct: 593 KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKA 652

Query: 324 SSLEKDEPR 332
            S EK+E +
Sbjct: 653 KSPEKEEAK 661


>gi|47933339 RNA binding motif protein 15 [Homo sapiens]
          Length = 977

 Score =  122 bits (307), Expect = 5e-27
 Identities = 118/445 (26%), Positives = 193/445 (43%), Gaps = 41/445 (9%)

Query: 422 FRPLDERIDEFHPKATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNG--VPQYA 479
           FR +DE   E   +A RTLF+GNL+ T T  DLR  F RFG I ++DIK+ +      Y 
Sbjct: 358 FREVDEISPEDDQRANRTLFLGNLDITVTESDLRRAFDRFGVITEVDIKRPSRGQTSTYG 417

Query: 480 FLQYCDIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCR 539
           FL++ ++    +A   M G+ +  N +K+G+GK+ PT  +W+ GL   V    L R F R
Sbjct: 418 FLKFENLDMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDR 477

Query: 540 YGPVVKVVFDRLKGMALVLYNEIEYAQAAVKETKGRKIGG--NKIKVDFANRESQLAFYH 597
           +G +  + + +    A + Y  ++ A AA    +G  +GG   +++VDFA+ E +    +
Sbjct: 478 FGTIRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQY 537

Query: 598 CMEKSGQDIRDFYEMLAERREER-----RASYDYNQDRTYYESVRTPGTYPEDSRRDYPA 652
                       YE++ +    R     R + D      Y +  R    YP+      P 
Sbjct: 538 LQPLP----LTHYELVTDAFGHRAPDPLRGARDRTPPLLYRD--RDRDLYPDSDWVPPPP 591

Query: 653 RGREFYSEWETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESD 712
             RE  +         YE      P +  D R D +  D          R+R      S 
Sbjct: 592 PVRERSTRTAATSVPAYE------PLDSLDRRRDGWSLD----------RDRGDRDLPSS 635

Query: 713 RDRDHERRPIERS------QSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSC 766
           RD+  +RR  E S      +SP    RP+    +PS        S R  Y+  +DRS S 
Sbjct: 636 RDQPRKRRLPEESGGRHLDRSP-ESDRPRKRHCAPSPDRSPELSSSRDRYNSDNDRS-SR 693

Query: 767 SSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKG 826
             L  P   +  +  LE+ ++ +K D++ +   ER +R+ R     + +     + +  G
Sbjct: 694 LLLERPSPIRDRRGSLEK-SQGDKRDRKNSASAER-DRKHRTTAPTEGKSPLKKEDRSDG 751

Query: 827 KVHSPSSQSSETDQENEREQSPEKP 851
              S S+ SS+    ++++     P
Sbjct: 752 SAPSTSTASSKLKSPSQKQDGGTAP 776



 Score = 84.0 bits (206), Expect = 3e-15
 Identities = 69/229 (30%), Positives = 97/229 (42%), Gaps = 22/229 (9%)

Query: 3436 SVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRP 3495
            S S + D        T  K PL     S  S P           P+ KQD          
Sbjct: 722  SASAERDRKHRTTAPTEGKSPLKKEDRSDGSAPSTSTASSKLKSPSQKQDGGT------- 774

Query: 3496 VDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRSLPLSEGG---PPLRIAQR 3552
              +     K  + WQG+L LKN      +H + G+  +A   L     G     L+I QR
Sbjct: 775  APVASASPKLCLAWQGMLLLKNSNFPSNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQR 834

Query: 3553 MRLEATQLEGVARRMTVE--TDYCLLLALPCGRDQE--------DVVSQTESLKAAFITY 3602
            +RL+  +L+ V RR+ V     Y +LLA+P   D          D  + T+      ++Y
Sbjct: 835  LRLDQPKLDEVTRRIKVAGPNGYAILLAVPGSSDSRSSSSSAASDTATSTQRPLRNLVSY 894

Query: 3603 LQAKQAAGIINVPNPGS--NQPAYVLQIFPPCEFSESHLSRLAPDLLAS 3649
            L+ KQAAG+I++P  G+   +   VL  FPPCEFS+  L   A  L  S
Sbjct: 895  LKQKQAAGVISLPVGGNKDKENTGVLHAFPPCEFSQQFLDSPAKALAKS 943



 Score = 68.9 bits (167), Expect = 9e-11
 Identities = 77/270 (28%), Positives = 114/270 (42%), Gaps = 39/270 (14%)

Query: 199 PRYEPRAREQFTL--PSVVHR--DIYRDDITREVRGRRPERN-YQHSRSRSPHSSQSRNQ 253
           PR  PR R    L   S   R   +  DD+ R    +  ER+  +  RSR    S SR +
Sbjct: 10  PRRSPRWRRAVPLCETSAGRRVTQLRGDDLRRPATMKGKERSPVKAKRSRGGEDSTSRGE 69

Query: 254 SPQRLA----SQASRPTRSPSGSGSR-------------SRSSSSDSISSSSSTSSDSSD 296
             ++L     S  S   ++ SG GSR             SR   +   SSSS   S SS 
Sbjct: 70  RSKKLGGSGGSNGSSSGKTDSGGGSRRSLHLDKSSSRGGSREYDTGGGSSSSRLHSYSSP 129

Query: 297 SSSSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFG-----IKVQNLPVRSTDTSL 351
           S+ +SS    +RS          S   S      P    G     +K+  L  + +D ++
Sbjct: 130 STKNSSGGGESRSSSRGGGGESRS---SGAASSAPGGGDGAEYKTLKISELGSQLSDEAV 186

Query: 352 KDGLFHEFKKFG----KVTSVQIHGTSEERYGLVFFRQQEDQEKALTASKGKLFFGMQIE 407
           +DGLFHEFK+FG    K++ +   G+ +ER   V FR+ ED   A  A    + +   ++
Sbjct: 187 EDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLVLYDRPLK 246

Query: 408 VTAWIGPETESENEFRPLDERIDEFHPKAT 437
           + A       S +   PLD+  D + P A+
Sbjct: 247 IEAVYVSRRRSRS---PLDK--DTYPPSAS 271



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 98/410 (23%), Positives = 145/410 (35%), Gaps = 84/410 (20%)

Query: 3   RETRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQKA 62
           R  R L++GNL   V E  +   F R+G +  V I  KR S G  + +  F+  ++   +
Sbjct: 371 RANRTLFLGNLDITVTESDLRRAFDRFGVITEVDI--KRPSRGQTSTY-GFLKFENLDMS 427

Query: 63  HNSVNKMGDR-----DLRTDYNE-PGTIPSAARGLDDTVSIASRSREVSGF-------RG 109
           H +   M  +      ++  Y +   T      GL   V +A+ +RE   F         
Sbjct: 428 HRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGTIRTIDYR 487

Query: 110 GGGGPAYGPPPSLHARE-----------GRYERRLDGASDNRERAYEHS-----AYGHHE 153
            G   AY    SL A             G  +RRL     + E  Y+          H+E
Sbjct: 488 KGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQYLQPLPLTHYE 547

Query: 154 RGTGGFDRTRHYDQDYYRDPRERT-------LQHGLYYAS---------RSRSPNRFDAH 197
             T  F    H   D  R  R+RT           LY  S         R RS       
Sbjct: 548 LVTDAFG---HRAPDPLRGARDRTPPLLYRDRDRDLYPDSDWVPPPPPVRERSTRTAATS 604

Query: 198 DPRYEP--------------RAREQFTLPSVVHRDIYRD-DITREVRGRRPERNYQHSRS 242
            P YEP              R R    LPS   RD  R   +  E  GR  +R+ +  R 
Sbjct: 605 VPAYEPLDSLDRRRDGWSLDRDRGDRDLPS--SRDQPRKRRLPEESGGRHLDRSPESDRP 662

Query: 243 RSPHSSQSRNQSPQ----------------RLASQASRPTRSPSGSGSRSRSSSSDSISS 286
           R  H + S ++SP+                RL  +   P R   GS  +S+    D  +S
Sbjct: 663 RKRHCAPSPDRSPELSSSRDRYNSDNDRSSRLLLERPSPIRDRRGSLEKSQGDKRDRKNS 722

Query: 287 SSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFG 336
           +S+       +++ +   SP +    +   AP++   SS  K   +K  G
Sbjct: 723 ASAERDRKHRTTAPTEGKSPLKKEDRSDGSAPSTSTASSKLKSPSQKQDG 772


>gi|54607124 RNA binding motif protein 15B [Homo sapiens]
          Length = 890

 Score =  113 bits (283), Expect = 3e-24
 Identities = 111/420 (26%), Positives = 181/420 (43%), Gaps = 67/420 (15%)

Query: 426 DERIDEFHPKATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKV--NGVPQYAFLQY 483
           ++ + E   +ATR LFIGNL+ + +  +LR  F+++G I ++ IK+        YAFL++
Sbjct: 325 EDLMPEDDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQGGAYAFLKF 384

Query: 484 CDIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRYGPV 543
            ++    +A   M G  +G N +K+G+GK+ PT  +W+ GL  N S   L R F R+G +
Sbjct: 385 QNLDMAHRAKVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSI 444

Query: 544 VKVVFDRLKG--MALVLYNEIEYAQAAVKETKGRKIGG--NKIKVDFANRESQLAFYHCM 599
             +  D +KG   A + Y  ++ AQAA  + +G  +GG   +++VDFA  E      +  
Sbjct: 445 RTI--DHVKGDSFAYIQYESLDAAQAACAKMRGFPLGGPDRRLRVDFAKAEET---RYPQ 499

Query: 600 EKSGQDIRDFYEMLAE-RREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYPARGREFY 658
           +     +   YE+L +     R    D  +DRT    +             Y  R R F 
Sbjct: 500 QYQPSPLPVHYELLTDGYTRHRNLDADLVRDRTPPHLL-------------YSDRDRTF- 545

Query: 659 SEWETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDR--DRD 716
                 +GD      +  P +  D RN      +  YS   R R  ER   + DR   + 
Sbjct: 546 -----LEGD------WTSPSKSSDRRN-----SLEGYSRSVRSRSGERWGADGDRGLPKP 589

Query: 717 HERRPIERSQSPVHLRRPQSPGASPSQ-----------AERLPSDSERRLYSRSSDRSGS 765
            E R   RS S    R   SP    S+           ++R P  S +  +S    +  S
Sbjct: 590 WEERRKRRSLSSDRGRTTHSPYEERSRTKGSGQQSERGSDRTPERSRKENHSSEGTKESS 649

Query: 766 CSSLSPPR------------YEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEK 813
            +SLS  R            +E  D S  ++   +E+  +    +P+ +E  +   +K K
Sbjct: 650 SNSLSNSRHGAEERGHHHHHHEAADSSHGKKARDSERNHRTTEAEPKPLEEPKHETKKLK 709



 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 56/200 (28%), Positives = 97/200 (48%), Gaps = 20/200 (10%)

Query: 3476 TEFQPAPKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAH 3535
            TE +P P ++  P   +++  ++ +  +   + W GLL LKN      +H + G+  +  
Sbjct: 691  TEAEPKPLEE--PKHETKKLKNLSEYAQTLQLGWNGLLVLKNSCFPTSMHILEGDQGVIS 748

Query: 3536 RSLPLSEGG---PPLRIAQRMRLEATQLEGVARRMT--VETDYCLLL---ALPCGRDQED 3587
              L     G     L+IAQR+RL+  +L+ V RR+       Y +LL   A P G   E 
Sbjct: 749  SLLKDHTSGSKLTQLKIAQRLRLDQPKLDEVTRRIKQGSPNGYAVLLATQATPSGLGTEG 808

Query: 3588 VVSQTESLKAA----FITYLQAKQAAGIINVPNPGS--NQPAYVLQIFPPCEFSESHLSR 3641
            + +    L+       ++YL+ KQAAG+I++P  GS       +L  FPPC+FS+ +L  
Sbjct: 809  MPTVEPGLQRRLLRNLVSYLKQKQAAGVISLPVGGSKGRDGTGMLYAFPPCDFSQQYLQ- 867

Query: 3642 LAPDLLASISNISPHLMIVI 3661
                 L ++  +    M+++
Sbjct: 868  ---SALRTLGKLEEEHMVIV 884



 Score = 72.4 bits (176), Expect = 8e-12
 Identities = 94/344 (27%), Positives = 139/344 (40%), Gaps = 50/344 (14%)

Query: 3   RETRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQKA 62
           R TR+L++GNL  +V E ++   F++YG +E V I      +GG  AF+ F ++  A +A
Sbjct: 334 RATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQGGAYAFLKFQNLDMAHRA 393

Query: 63  HNSVN--KMGDRDLRTDYNEPG-TIPSAARGLDDTVSIASRSREVSGFRG-------GGG 112
             +++   +G   ++  Y +   T      GL    S+A+ +RE   F          G 
Sbjct: 394 KVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGD 453

Query: 113 GPAYGPPPSLHARE-----------GRYERRL--DGASDNRER---AYEHSAYG-HHERG 155
             AY    SL A +           G  +RRL  D A     R    Y+ S    H+E  
Sbjct: 454 SFAYIQYESLDAAQAACAKMRGFPLGGPDRRLRVDFAKAEETRYPQQYQPSPLPVHYELL 513

Query: 156 TGGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDAHDPRYEPRAREQFTLPSVV 215
           T G+ R R+ D D  RD   RT  H L Y+ R R+    D   P      R         
Sbjct: 514 TDGYTRHRNLDADLVRD---RTPPH-LLYSDRDRTFLEGDWTSPSKSSDRRNSL------ 563

Query: 216 HRDIYRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSR 275
                 +  +R VR R  ER         P   + R +  + L+S   R T SP    SR
Sbjct: 564 ------EGYSRSVRSRSGERWGADGDRGLPKPWEERRKR-RSLSSDRGRTTHSPYEERSR 616

Query: 276 SRSS------SSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSA 313
           ++ S       SD     S   + SS+ +  SS +S + S   A
Sbjct: 617 TKGSGQQSERGSDRTPERSRKENHSSEGTKESSSNSLSNSRHGA 660



 Score = 45.8 bits (107), Expect = 8e-04
 Identities = 36/133 (27%), Positives = 54/133 (40%), Gaps = 16/133 (12%)

Query: 260 SQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPT 319
           + + R + S +G G R   +S D  +S  S  +             PA    SAA P   
Sbjct: 80  ASSGRSSGSGAGGGGRGGKASGDPGASGMSPRASPLPPPPPPPGAEPACPGSSAAAPEYK 139

Query: 320 SQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEFKKFGKVTSVQIHGTSEERYG 379
           + L+SSL    P +                 L+D LFH+FK+FG+++    H     R  
Sbjct: 140 TLLISSLSPALPAEH----------------LEDRLFHQFKRFGEISLRLSHTPELGRVA 183

Query: 380 LVFFRQQEDQEKA 392
            V FR  +D  +A
Sbjct: 184 YVNFRHPQDAREA 196


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score =  111 bits (278), Expect = 1e-23
 Identities = 210/838 (25%), Positives = 291/838 (34%), Gaps = 147/838 (17%)

Query: 2722 PGTVNAAASAVNATASAV-----TVTAGAVTAAS-------GGVTATTGTVTMAGAVIAP 2769
            P  V  AA  V   A AV        AG +  A+        G T + GT +   A   P
Sbjct: 36   PPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPP 95

Query: 2770 STKCKQRASANENSRFHPGSMPVIDD---RPADAGSGAGLRVNTSEGVVLLSYSGQKTEG 2826
            ++   +RA   +N+   P S P       RP   G   GLR++  E V      G+ TE 
Sbjct: 96   ASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQ-KGLRISAEETVA----RGKATEA 150

Query: 2827 PQRISAKISQ-------IPPASAMDIEFQQSVSKSQV---KPDSVTASQPPSKGPQAPAG 2876
            P+R +             P   +  +  +   + ++V   +P      +PP++GP+    
Sbjct: 151  PKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVS 210

Query: 2877 YANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVS-TPVTQGGTVKVLTQG 2935
             A+   HST          SP      +    L++P    LS S TP++         +G
Sbjct: 211  SAS--EHSTT-------EPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARG 261

Query: 2936 INTPPVLVHNQL-------VLTPSIVTTNKKLADPVTLKIETKVLQ-PANLGSTLTPHHP 2987
              TP    H           L P  VT  +K A P    + +  L  P+  G+   P  P
Sbjct: 262  --TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPP 319

Query: 2988 P-----ALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHP 3042
            P      LP+ LP      PS P            A  L    P PS P PS     S P
Sbjct: 320  PDNAATPLPATLP------PSPP-----------LATPLPLAPPSPSAP-PSLQTLPSPP 361

Query: 3043 SSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQT--------VSLSHLS 3094
            ++  S A  +  T  + A    P  + +I P    I  PHS+T          ++LS L 
Sbjct: 362  ATPPSQAPPSMTTPPMQA----PPSLQTIPP----IQVPHSLTSPSLQAPPSPLALSSL- 412

Query: 3095 QGEVRMNTPTLPSITYSIRPEALHS--PRAPLQPQQIEVRAPQRASTPQPAPAGVPALAS 3152
            Q    + +PTL         +A HS    +P Q Q       + ASTP  +P     L+ 
Sbjct: 413  QATTSLGSPTL---------QATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSL 463

Query: 3153 QHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRA 3212
               P  +      V+  ++P+    L   S    H    P    IM       +  Q   
Sbjct: 464  PASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIM-----PPLETQSSL 518

Query: 3213 ADGVVKVPPASKA-------------PQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAP 3259
            A   ++ PPAS               P Q       TP  +  P P P P+  P P P  
Sbjct: 519  APPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAP-PSPLT 577

Query: 3260 APAPHGEARILTVTP-------SNQLQGLPLTP--PVVVTHGVQIVHSSGELFQEYRYGD 3310
             P P   + I T  P       S  LQGLP  P  P+           +    Q      
Sbjct: 578  TPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPP 637

Query: 3311 IRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPP---PEGEPLQPPQPVQSTQPAQPAP 3367
                  P      Q P A +V L     +    PP   P   P  PP    +T P+Q  P
Sbjct: 638  ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 697

Query: 3368 PCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETG 3427
                  L  P  PP+S  P +S  A  T      P L A P   PP P      + + T 
Sbjct: 698  SLAAPPLQVPPSPPAS--PPMSPSA--TPPPQAPPPLAAPPLQVPPSPPASPPMSPSATP 753

Query: 3428 PTSFPSPVS---VSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAP 3482
            P   P  ++   + + P  P SLP     K P        P  PP L  P  +  P+P
Sbjct: 754  PPRVPPLLAAPPLQVPPSPPASLPMSPLAKPP--------PQAPPALATPPLQALPSP 803



 Score =  110 bits (275), Expect = 3e-23
 Identities = 219/900 (24%), Positives = 319/900 (35%), Gaps = 167/900 (18%)

Query: 2656 GLVNVSLVPVNALK-GPVKGSVTTLKSLVSTPAGPVNVLKGPV--NVLTGPVNVLTTPVN 2712
            G +  + +P +A + GP + + T+ ++  S P       + P   N   GPV+   +P  
Sbjct: 63   GGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVS---SPGR 119

Query: 2713 ATVGTVNAAP-GTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVT---------- 2761
            A+ GT    P G      SA    A      A   +A S G    T   T          
Sbjct: 120  AS-GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMAR 178

Query: 2762 ---MAGAVI-----APSTKC--------KQRASANENSRFHPGSMPVIDDRPADAGSGAG 2805
                AG  +     APS +         K  +SA+E+S   P   P    RP+   +G G
Sbjct: 179  RSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPS--PAARRRPS---AGGG 233

Query: 2806 LRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQ 2865
            L+   S     LS S      P R        P A A           SQ KP  + A +
Sbjct: 234  LQRPASRS---LSSSATPLSSPARSGPSARGTPRAPA---------HPSQPKPKGLQALR 281

Query: 2866 PPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQ 2925
            PP   P        +   S+  L      A+P  S  KA RP    P P + +   P T 
Sbjct: 282  PPQVTPPRKDAAPALGPLSSSPL------ATPSPSGTKA-RPV---PPPDNAATPLPATL 331

Query: 2926 GGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPH 2985
              +  + T     PP         +PS   + + L  P      T   Q     +T    
Sbjct: 332  PPSPPLATPLPLAPP---------SPSAPPSLQTLPSPPA----TPPSQAPPSMTTPPMQ 378

Query: 2986 HPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSF----PRA-- 3039
             PP+L +  P +V H  + PS+ A  +   L++ +       P+     SF    PR   
Sbjct: 379  APPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQ 438

Query: 3040 ------SHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHL 3093
                  S P+ST   +    A + L A  P+    +S+ P  S +  P +I    +LS L
Sbjct: 439  ASLTSPSRPASTPPDSPPLQAPLSLPASPPLQ---TSLSPAVSPLSSPLTIHPLQALSSL 495

Query: 3094 SQGEVRMNTPTLPSITYSIRPEALHSPRAP--LQPQQIEVRAPQRASTPQPAPAGVPALA 3151
            +      ++P  P  +  + P    S  AP  LQ     +  P   + P  AP   P L 
Sbjct: 496  AS-----HSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAP---PPLQ 547

Query: 3152 SQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTV----PRDVRIMVHPHVTAVS 3207
            +   P    H   P   A  P+Q+    + +     P ++    P+    +  P +  + 
Sbjct: 548  TASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLP 607

Query: 3208 EQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEA 3267
              P +       P A+  PQ P   A   P  +A P+P  +P   P+  P+P  AP+  A
Sbjct: 608  SPPLS-------PLATPPPQAPPXLAL--PPLQAPPSPPASPPLSPLATPSPQ-APNALA 657

Query: 3268 RILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPA 3327
              L   P +     P +PPV                          + PPA       P 
Sbjct: 658  VHLLQAPFSP----PPSPPVQAP-----------------------FSPPASP-----PV 685

Query: 3328 ASSVGLPSRTKTAAQGPP---PEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSK 3384
            + S   PS+   +   PP   P   P  PP    +T P Q  PP     L  P  PP+S 
Sbjct: 686  SPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPAS- 744

Query: 3385 MPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVS---VSMKP 3441
             P +S  A  T      P L A P   PP P   +  +     P   P  ++   +   P
Sbjct: 745  -PPMSPSA--TPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALP 801

Query: 3442 DLPVSLPTQ-------TAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQR 3494
              P S P Q       + P  PL  P    P  PP L  P  +  P+P   +SP L + R
Sbjct: 802  SPPASFPGQAPFSPSASLPMSPLATPP---PQAPPVLAAPLLQVPPSP--PASPTLQAPR 856



 Score = 79.0 bits (193), Expect = 8e-14
 Identities = 238/1115 (21%), Positives = 368/1115 (33%), Gaps = 184/1115 (16%)

Query: 2349 VAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPST 2408
            V P    V  +  A G  P A     +     P+   ++  P  +   S  +  S+ P++
Sbjct: 39   VTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAG-PTRSAGTSSRNPASRPPAS 97

Query: 2409 ENSSQEISVEERTPTKASVPPDLPPPPQPAPVD--------EEPQARFRVHSIIESDPVT 2460
                +    +  +P   S P       +P P+         EE  AR +     +   ++
Sbjct: 98   GRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALS 157

Query: 2461 PPS--DPSIPIPTLPSVTAAKLSPPVASG-GIPHQSPPTKVTEWITRQEEPRAQST-PSP 2516
              +  D S P P  PS   A+ S    +  G+P  +P  +          PR  +  P  
Sbjct: 158  AGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSAR----------PRPPTEGPRK 207

Query: 2517 ALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPV 2576
            ++   ++ S  + S +  R+           S + +S  T ++ P  + P     P  P 
Sbjct: 208  SVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPA 267

Query: 2577 DSKKP----LEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLE 2632
               +P    L+    P VT               ++  AP + P     +S  P++    
Sbjct: 268  HPSQPKPKGLQALRPPQVT-------------PPRKDAAPALGP-----LSSSPLATPSP 309

Query: 2633 NSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNV 2692
            +  K     P     T L + L    +  L     L  P   +  +L++L S PA P + 
Sbjct: 310  SGTKARPVPPPDNAATPLPATLPP--SPPLATPLPLAPPSPSAPPSLQTLPSPPATPPS- 366

Query: 2693 LKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTV--NAAASAVNATASAVTVTAGAVTAAS 2750
                      P ++ T P+ A        P  V  +  + ++ A  S + +++   T + 
Sbjct: 367  --------QAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSL 418

Query: 2751 GGVT--ATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRV 2808
            G  T  AT   +TM+      S     R ++       P S P+    P    +   L+ 
Sbjct: 419  GSPTLQATHSFLTMSPRQTQASLTSPSRPASTP-----PDSPPL--QAPLSLPASPPLQT 471

Query: 2809 NTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPS 2868
            + S  V  LS S       Q +S+  S  P A    +      ++S + P S+    PP+
Sbjct: 472  SLSPAVSPLS-SPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQT--PPA 528

Query: 2869 KGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGT 2928
                 P        +   +       AS  +++   + P    P P+    S P+T    
Sbjct: 529  SLTTPPL------ENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPS-PLT---- 577

Query: 2929 VKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPP 2988
                     TPP         TPS + T    A P       + L    L    TP  PP
Sbjct: 578  ---------TPPPE-------TPSSIATPPPQAPPALASPPLQGLPSPPLSPLATP--PP 619

Query: 2989 ALPSKLPTEVNHVPSGP---------SIPADRTVSHLAAAKLDA-HSPRPSGPGPSSF-P 3037
              P  L       P  P         + P+ +  + LA   L A  SP PS P  + F P
Sbjct: 620  QAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP 679

Query: 3038 RASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGE 3097
             AS P S ++T  S     + A  + VP    +  P      PP      ++   L    
Sbjct: 680  PASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQ--- 736

Query: 3098 VRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPE 3157
                 P  P  +  + P A   PR P       + AP     P P PA +P      PP 
Sbjct: 737  ----VPPSPPASPPMSPSATPPPRVPPL-----LAAPPLQVPPSP-PASLPMSPLAKPPP 786

Query: 3158 EEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVP--RDVRIMVHPHVTAVSEQPRAADG 3215
            +      P A AT P+Q+    + S     P   P      + + P  T   + P     
Sbjct: 787  QA-----PPALATPPLQA----LPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 837

Query: 3216 ----VVKVPPASKAPQQPGKEAAKTPDAKAAP---TPTPAPVPVPVPLPAPAPAPHGEAR 3268
                V   PPAS   Q P +     PD   +    T   AP P P P             
Sbjct: 838  PLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPP------------- 884

Query: 3269 ILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGEL--FQEYRYGDIRTYHPPAQLTHTQFP 3326
              + +PS+ L G     P +  H      +  EL  +     G      PP        P
Sbjct: 885  --SRSPSSTLSG-----PDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHP 937

Query: 3327 AASSVG-LPSRTKTAAQGPPPEGEPLQPPQ------PVQSTQPAQPAPPCPPSQLGQPGQ 3379
            AA S G  P      A G P    P   P        +  T+  + A P P +    PG 
Sbjct: 938  AAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGAL--DPGP 995

Query: 3380 PPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPE 3414
             P            GT  G       AG ++R P+
Sbjct: 996  SP------------GTSGGKAAAGAGAGASSRSPK 1018



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 171/813 (21%), Positives = 252/813 (30%), Gaps = 107/813 (13%)

Query: 1923 PVEQPRV--TRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEG 1980
            P   PR   TR         A+  P + R  R P  +  +     +  +    T   P G
Sbjct: 71   PESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLG 130

Query: 1981 WRSPR--SQKTAAGGGPQGKKGKNEPKVDATRPEATTEV-GPQIGVKESSMEPKAAEEEA 2037
             +  R  +++T A G     K    PK  A    A  +  GP  G    +M  ++    A
Sbjct: 131  QKGLRISAEETVARG-----KATEAPKRSALSAGARRDTSGPTPGTPSPAMARRS--RAA 183

Query: 2038 GSEQKRDRKDAGTDKNPPETAPVEVV---------EKKPAPEKNSKSKRGRSRNSRLAVD 2088
            G+E    R        PP   P + V         E  PA  +   +  G  R +  ++ 
Sbjct: 184  GTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 243

Query: 2089 KSAS------LKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLS-SQLKSDP 2141
             SA+           A  +PR  A  +  +  G+ A+ P +   P+K+   +   L S P
Sbjct: 244  SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP 303

Query: 2142 VDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADA------- 2194
            +        +      P   AT L   +     +     LA  S SA             
Sbjct: 304  LATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPAT 363

Query: 2195 PEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQ 2254
            P   AP     P  QA  +     I  I    S    +  APP     S        G+ 
Sbjct: 364  PPSQAPPSMTTPPMQAPPS--LQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSP 421

Query: 2255 ALQPSEEGMETDEAVSGILETE----AATESSRPPVNAP-----------------DPSA 2293
             LQ +   +      +    T     A+T    PP+ AP                  P +
Sbjct: 422  TLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLS 481

Query: 2294 GPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRK-------RNTNK 2346
             P      +  SS  SHS P+A  S  +   L  +      + ++           N   
Sbjct: 482  SPLTIHPLQALSSLASHS-PQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPS 540

Query: 2347 KVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHS-------TPPQSCT 2399
                P+++          E+P       +Q P +P      E P S        PP   +
Sbjct: 541  LAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALAS 600

Query: 2400 SDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAP-----VDEEPQA--RFRVH- 2451
              L  +PS   S       +  P  A  P   PP P  +P         PQA     VH 
Sbjct: 601  PPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHL 660

Query: 2452 -----SIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQE 2506
                 S   S PV  P  P    P  PS T    +PP  +      +PP +V        
Sbjct: 661  LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA------APPLQVPPSPPASP 714

Query: 2507 EPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAP 2566
                 +TP P  PP   A  +    S      M P       V        +  P S   
Sbjct: 715  PMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPA 774

Query: 2567 CLHEAP-------PPPVDSKKPLEEKTAPPVTNNSEIQASEVL------VAADKEKVAPV 2613
             L  +P        PP  +  PL+   +PP +   +   S         +A    +  PV
Sbjct: 775  SLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV 834

Query: 2614 IAPKITSVISRMPVSIDLENSQKITLAKPAPQT 2646
            +A  +  V    P S  L+  ++     P P T
Sbjct: 835  LAAPLLQVPPSPPASPTLQAPRR--PPTPGPDT 865



 Score = 63.5 bits (153), Expect = 4e-09
 Identities = 183/803 (22%), Positives = 262/803 (32%), Gaps = 158/803 (19%)

Query: 1974 TLKPPEGWRSPRSQKTAA-----GGGPQGKKGKNEPKVD---ATRPEATTEVGPQIGVKE 2025
            T +PP   R P     AA       G  G+K   E       AT PE+    GP      
Sbjct: 26   TPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGT 85

Query: 2026 SSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKR-GRSRNSR 2084
            SS  P +    +G  ++     A   KN   T+P  V     +P + S + R G      
Sbjct: 86   SSRNPASRPPASGRGER-----APPAKN---TSPGPV----SSPGRASGTTRPGPLGQKG 133

Query: 2085 LAVDKSASLKNVDAAVSPRGAAAQAGERE--SGVVAVSP-----EKSESPQKEDGLSSQL 2137
            L +    ++    A  +P+ +A  AG R   SG    +P      +S +   E GL    
Sbjct: 134  LRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPA 193

Query: 2138 KS-DPVDPDKEPEKEDVSAS-----GPSPEA---------TQLAKQMELEQAVEHIAKLA 2182
             S  P  P + P K   SAS      PSP A          Q      L  +   ++  A
Sbjct: 194  PSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPA 253

Query: 2183 EASASAAYKADAP-----------EGLAPEDRDKPAHQA-------SETELAAAIGSIIN 2224
             +  SA     AP           + L P     P   A       S + LA    S   
Sbjct: 254  RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTK 313

Query: 2225 -------DISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEA 2277
                   D +  P     PP  P  +   L PP  + +  PS + + +  A      ++A
Sbjct: 314  ARPVPPPDNAATPLPATLPPSPPLATPLPLAPP--SPSAPPSLQTLPSPPATP---PSQA 368

Query: 2278 ATESSRPPVNAPD--PSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKT 2335
                + PP+ AP    +  P     +  + S  +   P A  S +   +L         +
Sbjct: 369  PPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHS 428

Query: 2336 TRSRRKRNTNKKVVAPVE--SHVPESNQAQGE-------------SPA------------ 2368
              +   R T   + +P    S  P+S   Q               SPA            
Sbjct: 429  FLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHP 488

Query: 2369 --ANEGTTVQHPEAP--------QEEKQSEKPHS--TPPQSCTS-DLSKIPS-----TEN 2410
              A        P+AP         E + S  P S  TPP S T+  L  +PS      + 
Sbjct: 489  LQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQT 548

Query: 2411 SSQEISVE--ERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIP 2468
            +S  ++    E  P  A  P   PP P   P  E P       SI    P  PP+  S P
Sbjct: 549  ASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPS------SIATPPPQAPPALASPP 602

Query: 2469 IPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASD-- 2526
            +  LPS   + L+ P      P Q+PP      +     P A    SP   P  +A +  
Sbjct: 603  LQGLPSPPLSPLATP------PPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNAL 656

Query: 2527 -VDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAP---PPPVDSKKPL 2582
             V    +        P     +   S  V+ +   P  A P L   P   PP   +  P+
Sbjct: 657  AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM 716

Query: 2583 EEKTAPPVTNNSEIQASEVLV-------------AADKEKVAPVIAPKITSVISRMPVSI 2629
                 PP      + A  + V             A    +V P++A     V    P S+
Sbjct: 717  SPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASL 776

Query: 2630 DLENSQKITLAKPAPQTLTGLVS 2652
             +       LAKP PQ    L +
Sbjct: 777  PMS-----PLAKPPPQAPPALAT 794



 Score = 49.7 bits (117), Expect = 5e-05
 Identities = 52/223 (23%), Positives = 76/223 (34%), Gaps = 11/223 (4%)

Query: 1614 ENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKT 1673
            EN P       +   + L TP    PP      L++ PS L  TT      + + T    
Sbjct: 536  ENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPL--TTPPPETPSSIATPPPQ 593

Query: 1674 VEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDA 1733
              PA  S   +    P  +P+        PP A P      + A     +S    P    
Sbjct: 594  APPALASPPLQGLPSPPLSPL-----ATPPPQAPPXLALPPLQAPPSPPASPPLSPLATP 648

Query: 1734 KPPTPGA---SFSQAESNVDPEPDSTQPLSKPAQKSEEANE-PKAEKPDATADAEPDANQ 1789
             P  P A      QA  +  P P    P S PA      +  P ++ P + A        
Sbjct: 649  SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP 708

Query: 1790 KAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAA 1832
               A+P   P A+   +  PP+AA   +   S  +  P+  +A
Sbjct: 709  SPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSA 751



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 55/225 (24%), Positives = 76/225 (33%), Gaps = 20/225 (8%)

Query: 1617 PKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEP 1676
            P    + P    S + TPP   PP++    L+  PS           +AP       ++ 
Sbjct: 573  PSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQ- 631

Query: 1677 ATVSEEAKPASEPAPAPVEQ--------LEQVDLPPGADPDKEAAMMPAGVEEGSSGDQP 1728
            A  S  A P   P   P  Q        L Q    P   P  +A   P      S    P
Sbjct: 632  APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 691

Query: 1729 PYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDAN 1788
            P     PP    S +     V P P ++ P+S  A    +A  P A  P     + P + 
Sbjct: 692  P--SQAPP----SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASP 745

Query: 1789 QKAEAAPESQPPASEDLEVDPPVAAKDKKPNK---SKRSKTPVQA 1830
              + +A  + PP    L   PP+      P     S  +K P QA
Sbjct: 746  PMSPSA--TPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQA 788



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 47/204 (23%), Positives = 74/204 (36%), Gaps = 10/204 (4%)

Query: 1617 PKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEP 1676
            P +P ++P    S   TPP   PP +    L+  PS           + P         P
Sbjct: 738  PPSPPASPPMSPSA--TPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATP 795

Query: 1677 ATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAG--VEEGSSGDQPPYLDA- 1733
               +  + PAS P  AP      + + P A P  +A  + A   ++   S    P L A 
Sbjct: 796  PLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP 855

Query: 1734 -KPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAE 1792
             +PPTPG   S +   +        P       S   + P      ++A + P+  +  +
Sbjct: 856  RRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYD 915

Query: 1793 AAPE----SQPPASEDLEVDPPVA 1812
            + PE    + PP   +L    P A
Sbjct: 916  SGPEGGAAASPPPDAELAACHPAA 939



 Score = 40.0 bits (92), Expect = 0.043
 Identities = 153/759 (20%), Positives = 237/759 (31%), Gaps = 159/759 (20%)

Query: 1617 PKTPESAPENKDSELKTPPSVGPPSVTVV------------TLESAP-----SALEKTT- 1658
            P  P + P      + TPP   PPS+  +            +L++ P     S+L+ TT 
Sbjct: 358  PSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTS 417

Query: 1659 -GDKTVEA--PLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMM 1715
             G  T++A    +T       A+++  ++PAS P  +P  Q   + LP  A P  + ++ 
Sbjct: 418  LGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQ-APLSLP--ASPPLQTSLS 474

Query: 1716 PAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAE 1775
            PA           P        P  + S   S+  P+   +  +  P +       P  +
Sbjct: 475  PA---------VSPLSSPLTIHPLQALSSLASH-SPQAPLSSLIMPPLETQSSLAPPSLQ 524

Query: 1776 KPDATADAEPDANQKAEAAP----ESQPPASEDLEVD----------PPVAAKDKKPNKS 1821
             P A+    P  N  + A P     S P  +  LE            PP       P   
Sbjct: 525  TPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETP 584

Query: 1822 KRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASK 1881
                TP   A  ++   P+    + +    L    +P  +A   L L       +  AS 
Sbjct: 585  SSIATPPPQAPPALASPPL----QGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASP 640

Query: 1882 NSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEA 1941
               + L  P P  P       N  +V      H  ++P   P   P      ++      
Sbjct: 641  -PLSPLATPSPQAP-------NALAV------HLLQAPFSPPPSPP------VQAPFSPP 680

Query: 1942 AAVPTTPRRGRPPKT-RRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKG 2000
            A+ P +P    P +     A    +     PA     P     P++    A   P  +  
Sbjct: 681  ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA--APPLQVP 738

Query: 2001 KNEPKVDATRPEAT--TEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETA 2058
             + P      P AT    V P +      + P                      +PP + 
Sbjct: 739  PSPPASPPMSPSATPPPRVPPLLAAPPLQVPP----------------------SPPASL 776

Query: 2059 PVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVA 2118
            P+  + K P     +           LA     +L +      P     QA    S  + 
Sbjct: 777  PMSPLAKPPPQAPPA-----------LATPPLQALPS-----PPASFPGQAPFSPSASLP 820

Query: 2119 VSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKE----------DVSASG----------- 2157
            +SP  +  PQ    L++ L   P  P   P  +          D S SG           
Sbjct: 821  MSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP 880

Query: 2158 PSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAA 2217
            P P +   +  +       H +               PEG A       A    + ELAA
Sbjct: 881  PPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGA------AASPPPDAELAA 934

Query: 2218 AIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEA 2277
               +  +         PAPP          +   GA    P   G  + + +  I ETE 
Sbjct: 935  CHPAAWS-------RGPAPP-------LAFRGAPGAPLPWPPATGPGSADGLCTIYETE- 979

Query: 2278 ATESSRPPVNA--PDPSAGPTDTKEARGNSSETSHSVPE 2314
              ES+ P   A  P PS G +  K A G  +  S   P+
Sbjct: 980  GPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPK 1018



 Score = 39.3 bits (90), Expect = 0.073
 Identities = 164/739 (22%), Positives = 239/739 (32%), Gaps = 127/739 (17%)

Query: 1619 TPESAPENKDSELKTPPSVGPPSVTVV---------TLESAPSALEKTTGDKTVEAPLVT 1669
            TP +       + K   ++ PP VT            L S+P A    +G K    P   
Sbjct: 262  TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPD 321

Query: 1670 EEKTVEPATVSEEAK-----PASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSS 1724
               T  PAT+          P + P+P+    L+ +  PP   P +    M     +   
Sbjct: 322  NAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQA-- 379

Query: 1725 GDQPPYLDAKPPTP-GASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADA 1783
               PP L   PP     S +       P P +   L    Q +     P  +   +    
Sbjct: 380  ---PPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSL----QATTSLGSPTLQATHSFLTM 432

Query: 1784 EP---DANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPV 1840
             P    A+  + + P S PP S  L+   P++     P ++  S       AVS +  P+
Sbjct: 433  SPRQTQASLTSPSRPASTPPDSPPLQA--PLSLPASPPLQTSLS------PAVSPLSSPL 484

Query: 1841 TRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTR 1900
            T     +       S+SP+     L+   +E      T S  +   L+ P  SL      
Sbjct: 485  T--IHPLQALSSLASHSPQAPLSSLIMPPLE------TQSSLAPPSLQTPPASL------ 530

Query: 1901 RRNVRSVYATMGDHENRSPVKEPVEQPR---VTRKRLERELQEAAA---VPTTPRRGRPP 1954
                     T    EN   +  P  Q     +T   LE     A      P +P    PP
Sbjct: 531  ---------TTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPP 581

Query: 1955 KTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDA-TRPEA 2013
            +T   +          PA    P +G  SP     A    PQ       P + A   P A
Sbjct: 582  ET--PSSIATPPPQAPPALASPPLQGLPSPPLSPLAT-PPPQAPPXLALPPLQAPPSPPA 638

Query: 2014 TTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNS 2073
            +  + P      S   P A                    +PP + PV+     PA    S
Sbjct: 639  SPPLSPL--ATPSPQAPNALAVHL----------LQAPFSPPPSPPVQAPFSPPASPPVS 686

Query: 2074 KSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGL 2133
             S    S+          SL      V P   A+           +SP  +  PQ    L
Sbjct: 687  PSATPPSQ-------APPSLAAPPLQVPPSPPASP---------PMSPSATPPPQAPPPL 730

Query: 2134 SSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKAD 2193
            ++     P  P   P      ++ P P    L     L+      A L   S  A     
Sbjct: 731  AAPPLQVPPSPPASPPMS--PSATPPPRVPPLLAAPPLQVPPSPPASL-PMSPLAKPPPQ 787

Query: 2194 APEGLA-PEDRDKPAHQAS---ETELAAAIGSIINDISGEPENFP----AP----PPYPG 2241
            AP  LA P  +  P+  AS   +   + +    ++ ++  P   P    AP    PP P 
Sbjct: 788  APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPP 847

Query: 2242 ESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDT--- 2298
             S T LQ P      +P   G +T  +VSG   T A      PP     PS  P+ T   
Sbjct: 848  ASPT-LQAPR-----RPPTPGPDT--SVSGPRLTLALAPGPPPP-----PSRSPSSTLSG 894

Query: 2299 KEARGNSSETSHSVPEAKG 2317
             +  G+SS  + +  E +G
Sbjct: 895  PDLAGHSSSATSTPEELRG 913


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  110 bits (275), Expect = 3e-23
 Identities = 425/2026 (20%), Positives = 704/2026 (34%), Gaps = 376/2026 (18%)

Query: 791   TDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQSPEK 850
             T +E+   P+R+E     + K+ V+KD   K   K K  +P            RE+  +K
Sbjct: 8971  TPEEKKPPPKRIE-----VTKKAVKKD-AKKVVAKPKEMTP------------REEIVKK 9012

Query: 851   PRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKE--KEGKVIDHTPVEKLKAKLDNDTV 908
             P     L   KA +     ++ E +  + +TR KE  KE + +     EK +A      V
Sbjct: 9013  PPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAV----YEKKQAVHKEKRV 9068

Query: 909   KSSALDQKLQVSQTEPAKSDLSK---------LESVRMKVPKE------KGLSSHVEVVE 953
                + ++     + EP      +          E ++++  KE      +      E  E
Sbjct: 9069  FIESFEEPYDELEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYE 9128

Query: 954   KE-GRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKP-----------E 1001
             +E G  +  +  +       V  V  E  E    R   + +  +K  P           +
Sbjct: 9129  REEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEK 9188

Query: 1002  VKKSSPEMEDARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRE-----SKKIKLDR 1056
             ++K+S  ME+ +V   K P+VS + V      +  R PV++E+++ +     +KK+ +  
Sbjct: 9189  IEKTSRRMEEEKVQVTKVPEVSKKIV----PQKPSRTPVQEEVIEVKVPAVHTKKMVISE 9244

Query: 1057  LN-----------TVASPKDCQELAS-----ISVGSGSRPSSDLQARLGELAGESVENQE 1100
                          +V  P+  +E+ +     +++     P   +     + A E V    
Sbjct: 9245  EKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVP 9304

Query: 1101  VQSK--KPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLR-DETPERKSGQEK-------- 1149
             +  K   P P  P++ +  V +++ P     ++     +  E P++   +EK        
Sbjct: 9305  IPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKK 9364

Query: 1150  -----------SHSVNTEEKIGIDIDHTQS---------YRKQMEQSRRKQQMEMEIAKS 1189
                           V TEEKI I     +S          +K  E+ +   + E E+   
Sbjct: 9365  KEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPP 9424

Query: 1190  EKFGS-PKKDVDEYERRSLVHEVGK---PPQDVTDDSPPSKKKRM---DHVDFDI----- 1237
              K  + PKK V E E+ ++   V K   PP+         ++KR    + + F +     
Sbjct: 9425  PKVPALPKKPVPE-EKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVE 9483

Query: 1238  CTKRERNYRSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPY 1297
              T+ E +       SE+ E    S         E+E  +    ++       V+EK    
Sbjct: 9484  VTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEK---- 9539

Query: 1298  SNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPN 1357
               + +  + ++  P + + R++   + K K+     E    +     K+      V  P 
Sbjct: 9540  --LHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKV--PA 9595

Query: 1358  SIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRE 1417
              + K++         + P +VP +  +    K   P+   + E   L   + +R  ++ +
Sbjct: 9596  PVPKKEK--------VPPPKVPEEPKKPVPEKKVPPKVIKMEEP--LPAKVTERHMQITQ 9645

Query: 1418  RDERLSSSLERNKFYSFALDKTITPDTKALL---ERAKSLSSSREENWSFLDWDSRFANF 1474
              ++ L +  ++      A  K   P+        E+   L   REE     +  ++   F
Sbjct: 9646  EEKVLVAVTKKE-----APPKARVPEEPKRAVPEEKVLKLKPKREE-----EPPAKVTEF 9695

Query: 1475  RNNKDKEKVDS------APRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFAS 1528
             R    KE+  S       P+PI    + ++K R  +    ++     +EEE E  E    
Sbjct: 9696  RKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYT--LEEEAVSVQREEEYEEYE---- 9749

Query: 1529  RFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFM 1588
                     E D K  +  E  EE   +     Y ++  E      + I EP         
Sbjct: 9750  --------EYDYKEFEEYEPTEEYDQY---EEYEEREYERYEEHEEYITEP--------- 9789

Query: 1589  ELTRMQQKEKEKDQKPKEVEKQEDTENHPKTP------ESAPENK-----DSELKTPPSV 1637
                     EK    KP     +E     PK P      ++ PE K       +LK PP  
Sbjct: 9790  --------EKPIPVKP---VPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPK 9838

Query: 1638  GPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQL 1697
              P     V  E    ++ K   ++  E       K      V+EE  P      AP  ++
Sbjct: 9839  VPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMK--PKRVVAEEKVPVPRKEVAPPVRV 9896

Query: 1698  EQVDLPPGADPDKEA--AMMPAGVEEGSSGDQPPYLDAKPP-------TPGASFSQAESN 1748
              +V  P   +P++ A    +   VEE    ++  Y+  +          P       E  
Sbjct: 9897  PEV--PKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVP 9954

Query: 1749  VDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVD 1808
               P P+  +P+  P  K +EA  P A+ P+     +P+         + +PP ++  EV 
Sbjct: 9955  RKPVPEEKKPV--PVPKKKEA--PPAKVPE--VPKKPEEKVPVLIPKKEKPPPAKVPEVP 10008

Query: 1809  PPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLEL 1868
                  ++K P    +      A    + +KPV  K   +   K K    P    +   +L
Sbjct: 10009 KKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPK-KVEAPPAKVPEVPKKL 10067

Query: 1869  KMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPR 1928
               E +K T    K     +E P P +P                   + R PV  PV  P+
Sbjct: 10068 IPEEKKPTPVPKK-----VEAPPPKVP-------------------KKREPVPVPVALPQ 10103

Query: 1929  VTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEE---ENEAKEPAETLKPPEGWRSPR 1985
                   E E+     V        P +     +EEE   E E   P E   PPE    P 
Sbjct: 10104 EEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPE 10163

Query: 1986  SQKTAAGGGPQGKKGKNEPKVDATRP-----EATTEVGPQIGVKESSMEPKAAEEEAGSE 2040
              ++       +    + +PKV    P     +  TE    I  KE +   K  E     E
Sbjct: 10164 EEEFVP---EEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVE 10220

Query: 2041  QKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAV 2100
             +KR            E  PVEV E +P  E  S+ +           ++  S++ V+   
Sbjct: 10221 EKRI-----ILPKEEEVLPVEVTE-EPEEEPISEEE---------IPEEPPSIEEVEEVA 10265

Query: 2101  SPR------GAAAQAGERESGVVAVSPEK--SESPQKEDGLSSQLKSDPVD-----PDKE 2147
              PR       A  +A       V   P K   + P+++  +  Q K  P       P K 
Sbjct: 10266 PPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKV 10325

Query: 2148  PEKEDV----SASGPSPEATQLAKQME-----------------LEQAVEHIAKLAEASA 2186
             PEK+ +     A  P+   T L +++                  +E  VE I +  E   
Sbjct: 10326 PEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHE 10385

Query: 2187  SAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEP----ENFPAPPPYPGE 2242
                Y  +       E      H+  E      +  +I     E     E   APP  P  
Sbjct: 10386 VEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEI 10445

Query: 2243  SQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEAR 2302
             S+  + P      + P +   E    V  + +     E  R P    +P   PT   E  
Sbjct: 10446 SEKIIPPKKPPTKVVPRK---EPPAKVPEVPKKIVVEEKVRVP---EEPRVPPTKVPEV- 10498

Query: 2303  GNSSETSHSVPEAKGSKEVEVTLVRKDKG-RQKTTRSRRKRNTNKKVVAP---------- 2351
                      VPE    K+V V   +K +    K   + ++    KKV  P          
Sbjct: 10499 ---LPPKEVVPE----KKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPT 10551

Query: 2352  ----------VESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSD 2401
                        E  VPE+   + ESP        + PEAP+E    +K  + PP+     
Sbjct: 10552 KVPEVPKAAVPEKKVPEAIPPKPESPPP------EVPEAPKEVVPEKKVPAAPPKKPEVT 10605

Query: 2402  LSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTP 2461
               K+P    + +E+  E++ P    VPP   P   P  V E P+       + E+ P  P
Sbjct: 10606 PVKVP---EAPKEVVPEKKVP----VPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKP 10658

Query: 2462  PSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVT---EWITRQEEPRAQSTPSPAL 2518
              S P  P         A   PP      P  + P +VT   +    +++  A     P L
Sbjct: 10659 ESPP--PEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPEL 10716

Query: 2519  PPDTKASDVDTSSSTLRKI-LMDPKYVSATSVTSTSV-TTAIAEPVSAAPCLHEAPP--- 2573
             PP  K  +V       +K+ L+ PK   A       V    + E   A P   E PP   
Sbjct: 10717 PP-VKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKV 10775

Query: 2574  PPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAP--VIAPK 2617
             P V  K  LEEK A PV   +E    EV    + E++AP   IAP+
Sbjct: 10776 PEVPKKPVLEEKPAVPVPERAESPPPEVY--EEPEEIAPEEEIAPE 10819



 Score =  105 bits (262), Expect = 8e-22
 Identities = 257/1261 (20%), Positives = 440/1261 (34%), Gaps = 173/1261 (13%)

Query: 1422  LSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKE 1481
             +SS  E  K  +    K +  + +A+ E+ +++    +E   F++      +F    D+ 
Sbjct: 9030  VSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAV---HKEKRVFIE------SFEEPYDEL 9080

Query: 1482  KVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQ---ERQELFASRFLHSSIFEQ 1538
             +V+    P    Y ++       E K++ KKE H+E E+   E QE +     +    E+
Sbjct: 9081  EVEPYTEPFEQPYYEEPD-EDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEE 9139

Query: 1539  DSKRLQHLE----RKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQ 1594
               +  Q  E    +KE   +    ++  K   + A      I++PV+    +  + +R  
Sbjct: 9140  WEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVI---EKIEKTSRRM 9196

Query: 1595  QKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSAL 1654
             ++EK +  K  EV K+   +   +TP    + +  E+K P      +  +V  E      
Sbjct: 9197  EEEKVQVTKVPEVSKKIVPQKPSRTPV---QEEVIEVKVP---AVHTKKMVISEEKMFFA 9250

Query: 1655  EKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAM 1714
               T  + +V  P V +E   E       +K    P   P       +LP    P++ A +
Sbjct: 9251  SHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVP-------ELPEKPAPEEVAPV 9303

Query: 1715  -MPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPK 1773
              +P  VE              PP P       E    P P+  +P+  P  K E A  PK
Sbjct: 9304  PIPKKVE--------------PPAPKVP----EVPKKPVPEEKKPV--PVPKKEPAAPPK 9343

Query: 1774  AEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAA- 1832
                P+      P+       A + + P ++  EV   V  ++K    ++R ++P  A   
Sbjct: 9344  V--PEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPE 9401

Query: 1833  -----VSIVEKPVTRKSER--------------IDREKL-------KRSNSPRGEAQK-- 1864
                  V    KPV RK E               +  EK+       K++  PR E  K  
Sbjct: 9402  IPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKT 9461

Query: 1865  -LLELKMEAEKITRTASKNSAADLEH---PEPSLPLSRTRRRNVRSVYATMGDHENRSPV 1920
              + E +  AE+    A         H    E     S        SVY    + E     
Sbjct: 9462  VVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYR---EEEREEEE 9518

Query: 1921  KEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEG 1980
             +  V +  V  +  E  ++E   + +      P +   R +++   + K PA+  +PP  
Sbjct: 9519  EAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPA 9578

Query: 1981  WRSPRSQKTAAG----GGPQGKKGK-NEPKV--DATRPEATTEVGPQIGVKESSMEPKAA 2033
              + P + K          P  KK K   PKV  +  +P    +V P++   E  +  K  
Sbjct: 9579  -KVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVT 9637

Query: 2034  EEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEK---NSKSKRGRSRNSRLAVDKS 2090
             E      Q+     A T K  P  A V    K+  PE+     K KR     +++   + 
Sbjct: 9638  ERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRK 9697

Query: 2091  ASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEK 2150
               +K    ++     A +   +    V +  EK  +   E+   S  + +  +  +E + 
Sbjct: 9698  RVVKEEKVSIE----APKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDY 9753

Query: 2151  EDVSASGPSPEATQLA--KQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAH 2208
             ++     P+ E  Q    ++ E E+  EH   + E       K    E +  + +  PA 
Sbjct: 9754  KEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAK 9813

Query: 2209  QASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEA 2268
                +      +   I      P+    PPP   E    +       ++   E+   T+ A
Sbjct: 9814  VLKKAVPEEKVPVPI------PKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPA 9867

Query: 2269  VSGILETEAATESSRPPV---NAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTL 2325
                 ++ +      + PV       P   P   KE            PE    +E  VT 
Sbjct: 9868  AKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELE----------PEEVAFEEEVVT- 9916

Query: 2326  VRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEK 2385
                              +  + +V   E ++ E  +   E         V+ PE P++  
Sbjct: 9917  -----------------HVEEYLVEEEEEYIHEEEEFITEEEVV-PVIPVKVPEVPRKPV 9958

Query: 2386  QSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQ 2445
               EK     P+   +  +K+P      +E  V    P K   PP   P     PV EE +
Sbjct: 9959  PEEKKPVPVPKKKEAPPAKVPEVPKKPEE-KVPVLIPKKEKPPPAKVPEVPKKPVPEE-K 10016

Query: 2446  ARFRVHSIIESDPVTPPSDPSIPIP--TLPSVTAAKLS------PPVASGGIPHQSPPTK 2497
                 V   +E+ P   P  P  P+P   +P     K+       P V    IP +  PT 
Sbjct: 10017 VPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTP 10076

Query: 2498  VTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTA 2557
             V         P+    P P +P   +   V  +     ++L + + V    V        
Sbjct: 10077 V---------PKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEE-EEV 10126

Query: 2558  IAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPK 2617
             + E     P   E    P + + P EE+  PP     E    E      +E+V P + PK
Sbjct: 10127 LPEEEEVLP--EEEEVLPEEEEIPPEEEEVPP----EEEYVPEEEEFVPEEEVLPEVKPK 10180

Query: 2618  I 2618
             +
Sbjct: 10181 V 10181



 Score = 99.0 bits (245), Expect = 8e-20
 Identities = 251/1110 (22%), Positives = 404/1110 (36%), Gaps = 165/1110 (14%)

Query: 1600  KDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTG 1659
             K+++   VE  E+ E  P + E  PE   S ++    V PP V  V  ++ P A   T  
Sbjct: 10228 KEEEVLPVEVTEEPEEEPISEEEIPEEPPS-IEEVEEVAPPRVPEVIKKAVPEA--PTPV 10284

Query: 1660  DKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGV 1719
              K VEAP         PA VS+  K   E  P PV++ E    PP   P+     +P  V
Sbjct: 10285 PKKVEAP---------PAKVSK--KIPEEKVPVPVQKKEA---PPAKVPE-----VPKKV 10325

Query: 1720  EEGSSGDQPPYLDAKPPTPG---------ASFSQ--------------AESNVDPEPDST 1756
              E       P  +A PP  G          +F Q              AE    PE +  
Sbjct: 10326 PEKKV--LVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEF 10383

Query: 1757  QPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDK 1816
               + +  ++ E     +  K +     E    +K     E     +E++EV     A  K
Sbjct: 10384 HEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFE--AEEVEVFEKPKAPPK 10441

Query: 1817  KPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDR-----EKLKRSNSPRGEAQKLLELKME 1871
              P  S++   P +     +  K    K   + +     EK++    PR    K+ E+   
Sbjct: 10442 GPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPP 10501

Query: 1872  AEKIT-RTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVT 1930
              E +  +      A   E P P +P +       + V         + P   P + P V 
Sbjct: 10502 KEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVP----PPKKPEVPPTKVPEVP 10557

Query: 1931  RKRL-ERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGW--RSPRSQ 1987
             +  + E+++ EA  +P  P    PP     A +E   E K PA   K PE    + P + 
Sbjct: 10558 KAAVPEKKVPEA--IPPKPES--PPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAP 10613

Query: 1988  KTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSM------EPKAAEEEAGSEQ 2041
             K      P+ K     PK     P    EV P++ V E  +      +P++   E   E 
Sbjct: 10614 KEVV---PEKKVPVPPPKKPEVPPTKVPEV-PKVAVPEKKVPEAIPPKPESPPPEVFEEP 10669

Query: 2042  KR---DRKDAGTDKNPPETAP--VEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNV 2096
             +    +   A   + P   AP  V V  KKP PEK + +           V K   L  V
Sbjct: 10670 EEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPA----------VVAKKPELPPV 10719

Query: 2097  DAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKE---PEKEDV 2153
                  P+         E  V  V P+K E+P  +     ++  + V P+K+   P+K +V
Sbjct: 10720 KVPEVPKEVVP-----EKKVPLVVPKKPEAPPAK---VPEVPKEVV-PEKKVAVPKKPEV 10770

Query: 2154  SASGPSPEATQLAKQMELEQA-VEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASE 2212
                 P  +  ++ K+  LE+     + + AE+     Y  + PE +APE+   P     E
Sbjct: 10771 ----PPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVY--EEPEEIAPEEEIAP-----E 10819

Query: 2213  TELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGI 2272
              E    +         EPE    PPP   E    + P      ++  E     +     +
Sbjct: 10820 EEKPVPVAE-----EEEPE---VPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKV 10871

Query: 2273  LETEAATESSRPPVNAPDPSAGPTDTKEARGN-SSETSHSVPEAKGSKE-VEVTLVRKDK 2330
             +E        RPP   P P+    D KE      +     VPE     E VE+T ++   
Sbjct: 10872 IEKPKL--KPRPP--PPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPG 10927

Query: 2331  GRQKTTRSRRKRNTNKK---VVAPVESHVPESNQAQGESPAANE--GTTVQHPEAPQEEK 2385
             G +K  +   +R    K   V+  V    PE  + + E     +     V  P  P+  +
Sbjct: 10928 GEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVE 10987

Query: 2386  QSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPP--PQPAPVDEE 2443
             + E P  T  +    + +K+P  + +    + E +   +A V    PPP  P+P P+   
Sbjct: 10988 EVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPI--- 11044

Query: 2444  PQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWIT 2503
                         + PVT P          P   AAK   P+   G+P ++P     E   
Sbjct: 11045 ------------AAPVTVPVVGKKAEAKAPKEEAAKPKGPIK--GVPKKTPSPIEAE--R 11088

Query: 2504  RQEEPRAQSTPSPALPPDT---KASDVDTSSSTLRKILMDPKYVSATSVTS--TSVTTAI 2558
             R+  P +     P   P T   KA  +         IL + ++V ++++     S +TAI
Sbjct: 11089 RKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAI 11148

Query: 2559  AEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKI 2618
                +     + E+P     +     +     V  +   + + VL   +KEK +       
Sbjct: 11149 TTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTA----- 11203

Query: 2619  TSVISRMPVSIDLENSQKITLAKPAPQTLT 2648
               V+  +PV       +++T+ K  P  L+
Sbjct: 11204 KLVVEELPVRFVKTLEEEVTVVKGQPLYLS 11233



 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 254/1134 (22%), Positives = 405/1134 (35%), Gaps = 165/1134 (14%)

Query: 1588  MELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPE--SAPENKDSELKTPPSVGPPSVTVV 1645
             +++  + +K   +++KP  V K+++     K PE    PE K   L  P    PP   V 
Sbjct: 9948  VKVPEVPRKPVPEEKKPVPVPKKKEAPP-AKVPEVPKKPEEKVPVL-IPKKEKPPPAKVP 10005

Query: 1646  TLESAPSALEKTTGD--KTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLP 1703
              +   P   EK      K VEAP         PA V E  K        PV   ++V+ P
Sbjct: 10006 EVPKKPVPEEKVPVPVPKKVEAP---------PAKVPEVPKKPVPEKKVPVPAPKKVEAP 10056

Query: 1704  PGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPA 1763
             P   P+    ++P   EE      P  ++A PP       +     +P P    P++ P 
Sbjct: 10057 PAKVPEVPKKLIP---EEKKPTPVPKKVEAPPP-------KVPKKREPVP---VPVALPQ 10103

Query: 1764  QKS---EEANEPKAE----KPDATADAEPDANQKAEAAPESQ--PPASEDLEVDPPVAAK 1814
             ++    EE   P+ E    + +   + E    ++ E  PE +  PP  E++  +     +
Sbjct: 10104 EEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPE 10163

Query: 1815  DKK--PNKSK----RSKTPVQAAAVSIVEKPVTRKSERIDREK----LKRSNSPRGEAQK 1864
             +++  P +      + K PV A  V  ++K VT K   I +++     K    P+   +K
Sbjct: 10164 EEEFVPEEEVLPEVKPKVPVPAP-VPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEK 10222

Query: 1865  LLELKMEAE----KITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDH--ENRS 1918
              + L  E E    ++T    +   ++ E PE    +          V   +     E  +
Sbjct: 10223 RIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPT 10282

Query: 1919  PVKEPVEQP--RVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLK 1976
             PV + VE P  +V++K  E    E   VP   +   P K      +  E +   P +   
Sbjct: 10283 PVPKKVEAPPAKVSKKIPE----EKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAV 10338

Query: 1977  PPEGWRSPRSQKTAAGGGPQGK-KGKNEPKVDATRPEATTEVGPQIGVKESSMEPK--AA 2033
             PP   R+   +K +     +   K + E +V     E   E      V+E   E +    
Sbjct: 10339 PPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEV 10398

Query: 2034  EEEAGSEQKRDRKDAGTDK-----NPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVD 2088
             EE    EQ R  ++   +K        E   VEV EK  AP K  +    +    +    
Sbjct: 10399 EEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISE-KIIPPKKPPT 10457

Query: 2089  KSASLKNVDAAVS--PRGAAAQAGERESGVVAVSPEKSES--PQKEDGLSSQLKSDPVDP 2144
             K    K   A V   P+    +   R      V P K     P KE       K  PV P
Sbjct: 10458 KVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKE---VVPEKKVPVPP 10514

Query: 2145  DKEPEKEDVSASGPSPEATQLAKQMELEQAVE---------HIAKLAEASASAAYKADAP 2195
              K+PE        P P+  +  K++  E+ V             K+ E   +A  +   P
Sbjct: 10515 AKKPE-------APPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVP 10567

Query: 2196  EGLAPEDR-------DKPAHQASETELAAA-----------IGSIINDISGEPENFPAPP 2237
             E + P+         + P     E ++ AA           +     ++  E +  P PP
Sbjct: 10568 EAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPE-KKVPVPP 10626

Query: 2238  PYPGESQTDLQPPAGAQALQ----PSEEGMETDEAVSGILETEAATESSRPP---VNAPD 2290
             P   E      P     A+     P     + +     + E         PP   V  P+
Sbjct: 10627 PKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPE 10686

Query: 2291  PSAGPTDTKEARGNSSETSHSVPEAKGSK--EVEVTLVRKDKGRQKTTR---SRRKRNTN 2345
             P+A P  T   +    E       AK  +   V+V  V K+   +K       ++     
Sbjct: 10687 PAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPP 10746

Query: 2346  KKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKI 2405
              KV    +  VPE   A  + P   E    + PE P++    EKP    P+   S   ++
Sbjct: 10747 AKVPEVPKEVVPEKKVAVPKKP---EVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEV 10803

Query: 2406  ---PSTENSSQEISVEERTPTKAS--VPPDLPPPPQPAPVDEEPQARF--RVHSIIESDP 2458
                P      +EI+ EE  P   +    P++PPP  P    EEP+     +   +I+   
Sbjct: 10804 YEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVP----EEPKKIIPEKKVPVIKKPE 10859

Query: 2459  VTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTK-VTEWITRQEE-PRAQSTPSP 2516
               PP +P  P   +         PP      P  +PP + V E I + +  P+ +    P
Sbjct: 10860 APPPKEPE-PEKVIEKPKLKPRPPP------PPPAPPKEDVKEKIFQLKAIPKKKVPEKP 10912

Query: 2517  ALPPDTKAS--DVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVS----------- 2563
              +P   + +   V      +RK+L + K      V   SV     E              
Sbjct: 10913 QVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKV 10972

Query: 2564  AAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPK 2617
               P + E PPP     KP+EE   P VT   E +  E     + +   P+ AP+
Sbjct: 10973 KKPAVPEPPPP-----KPVEEVEVPTVTKR-ERKIPEPTKVPEIKPAIPLPAPE 11020



 Score = 90.1 bits (222), Expect = 4e-17
 Identities = 252/1212 (20%), Positives = 406/1212 (33%), Gaps = 193/1212 (15%)

Query: 1592  RMQQKEKEKDQKPKEVEKQEDTENH-------------PKTPESAPENKDSELKTPPSVG 1638
             R +++E+E++ +  E E  E+ E +                P    E ++ ++   P + 
Sbjct: 9510  REEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKI- 9568

Query: 1639  PPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPA------------ 1686
             P  +        P A +K   +K V AP+  +EK   P    E  KP             
Sbjct: 9569  PAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKM 9628

Query: 1687  SEPAPAPVE----QLEQVDLPPGADPDKEA---AMMP----AGVEEGSSGDQPPYLDAKP 1735
              EP PA V     Q+ Q +    A   KEA   A +P      V E       P  + +P
Sbjct: 9629  EEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEP 9688

Query: 1736  PTPGASF-----SQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEP----- 1785
             P     F      + + +++      QP+ +     E+      E+   +   E      
Sbjct: 9689  PAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEY 9748

Query: 1786  ---DANQKAEAAPESQPPASEDLE-------------VDPPVAAKDKKPNKSKRSKTPVQ 1829
                D  +  E  P  +    E+ E             +  P      KP   +   T  +
Sbjct: 9749  EEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPK 9808

Query: 1830  AAAVSIVEKPVTRKSERIDREKLKRSNSPR--GEAQKLLELKMEAEKITRTASKNSAADL 1887
             A    +++K V  +   +   K  +   P+   E +K+ E     EKI  + +K     +
Sbjct: 9809  APPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFE-----EKIRISITKREKEQV 9863

Query: 1888  EHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTT 1947
               P   +P+   R      V A       R  V  PV  P V ++    E+     V T 
Sbjct: 9864  TEPAAKVPMKPKR------VVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTH 9917

Query: 1948  PRRGRPPKTRRRADEEEE---NEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEP 2004
                    +      EEEE    E   P   +K PE  R P          P+ KK    P
Sbjct: 9918  VEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKP---------VPEEKKPVPVP 9968

Query: 2005  KVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNP------PETA 2058
             K     P    EV  +   K   + PK  +       +  +K    +K P       E  
Sbjct: 9969  KKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAP 10028

Query: 2059  PVEV--VEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQA------- 2109
             P +V  V KKP PEK       +   +  A       K +     P     +        
Sbjct: 10029 PAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKV 10088

Query: 2110  -GERESGVVAVS--------------PEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVS 2154
               +RE   V V+              PE+   P++E+ L  + +  P + +  PE+E++ 
Sbjct: 10089 PKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIP 10148

Query: 2155  ASGPS--------PEATQLAKQMELEQAV-----------EHIAKLAEASASAAYKADAP 2195
                          PE  +   + E+   V           E   K+ E       K +AP
Sbjct: 10149 PEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAP 10208

Query: 2196  EGLAPEDRDKPAHQ----ASETELAAAIGSIINDISGEP---ENFPAPPPYPGESQTDLQ 2248
                 PE   K   +      E E+      +  +   EP   E  P  PP   E + ++ 
Sbjct: 10209 PAKVPEVPKKVEEKRIILPKEEEVLPV--EVTEEPEEEPISEEEIPEEPPSIEEVE-EVA 10265

Query: 2249  PPAGAQALQPSEEGMETDEAVSGILETEAATES-----SRPPVNAPDPSAGPTDTKEARG 2303
             PP   + ++ +    E    V   +E   A  S      + PV      A P    E   
Sbjct: 10266 PPRVPEVIKKAVP--EAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPK 10323

Query: 2304  NSSETSHSVPEAKGSKEVEVTLVRKDK-----GRQKTTRSRRKRNTNKKVVAPV----ES 2354
                E    VP+ +     +   V ++K      ++   + R +    +  V  +    E 
Sbjct: 10324 KVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEF 10383

Query: 2355  HVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPP--QSCTSDLSKIPSTENSS 2412
             H  E    +GE     E   ++     +EE + EK H      ++   ++ + P      
Sbjct: 10384 HEVEEYFEEGEFHEVEEFIKLEQHRV-EEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKG 10442

Query: 2413  QEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTL 2472
              EIS E+  P K      +P    PA V E P+       I+  + V  P +P +P   +
Sbjct: 10443 PEIS-EKIIPPKKPPTKVVPRKEPPAKVPEVPK------KIVVEEKVRVPEEPRVPPTKV 10495

Query: 2473  PSVTAAKLSPPVASGGIP----HQSPPTKVTEWITRQEEPRAQSTPSPALP--PDTKASD 2526
             P V   K   P     +P     ++PP KV E        +    P P  P  P TK  +
Sbjct: 10496 PEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPE 10555

Query: 2527  VDTSSSTLRKI--LMDPKYVSATSVTSTSVTTAIAE-PVSAAPCLHEAPPP---PVDSKK 2580
             V  ++   +K+   + PK  S       +    + E  V AAP       P   P   K+
Sbjct: 10556 VPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKE 10615

Query: 2581  PLEEKTAP-PVTNNSEIQASEV----LVAADKEKVAPVIAPKITS---VISRMPVSIDLE 2632
              + EK  P P     E+  ++V     VA  ++KV   I PK  S    +   P  + LE
Sbjct: 10616 VVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALE 10675

Query: 2633  NSQKITLAKPAP 2644
                   + +P P
Sbjct: 10676 EPPAEVVEEPEP 10687



 Score = 85.9 bits (211), Expect = 7e-16
 Identities = 240/1179 (20%), Positives = 418/1179 (35%), Gaps = 166/1179 (14%)

Query: 1496  KKKKIRTDSEGKMDDKKEDHKEE-------EQERQELFASRFLHSSIFEQDSKRLQHLER 1548
             +KK+++ + E   + K+  HKE+       E+   EL    +     FEQ      + E 
Sbjct: 9044  RKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEP--FEQP-----YYEE 9096

Query: 1549  KEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVE 1608
              +ED + I      K+  E      +  QE    ++ R       +++ +E  Q+ + ++
Sbjct: 9097  PDEDYEEIKVEAK-KEVHEEWEEDFEEGQE----YYEREEGYDEGEEEWEEAYQEREVIQ 9151

Query: 1609  KQEDT--ENHP-KTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEA 1665
              Q++   E+H  K P   PE K      PP   PP V           ++K   +K  + 
Sbjct: 9152  VQKEVYEESHERKVPAKVPEKK-----APP---PPKV-----------IKKPVIEKIEKT 9192

Query: 1666  PLVTEEKTVEPATVSEEAKPA--SEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGS 1723
                 EE+ V+   V E +K     +P+  PV++ E +++   A   K+  +         
Sbjct: 9193  SRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQE-EVIEVKVPAVHTKKMVI--------- 9242

Query: 1724  SGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADA 1783
             S ++  +          +  + +  +  E      +SK         EP  + P+     
Sbjct: 9243  SEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRV-------EPPPKVPELPEKP 9295

Query: 1784  EPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRK 1843
              P+         + +PPA +  EV      ++KKP    + +         + +KPV   
Sbjct: 9296  APEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPV--P 9353

Query: 1844  SERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRN 1903
              E+I     K+  +P  +  ++ +  +  EKIT    +      E P P++P    +   
Sbjct: 9354  EEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQRE-----ESPPPAVPEIPKK--- 9405

Query: 1904  VRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEE 1963
                              K P E+  V RK  E E+     VP  P++  P         E
Sbjct: 9406  -----------------KVPEERKPVPRK--EEEVPPPPKVPALPKKPVP---------E 9437

Query: 1964  EENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGV 2023
             E+     P     PP   R+  S+KT      + K+   E K+    P+       ++  
Sbjct: 9438  EKVAVPVPVAKKAPPP--RAEVSKKTVV----EEKRFVAEEKLSFAVPQRVEVTRHEVSA 9491

Query: 2024  KESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSK----SKRGR 2079
             +E   E   +EEE G      R++   ++   E    EV+E+        K    SKR  
Sbjct: 9492  EE---EWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVE 9548

Query: 2080  SRNSRLA--VDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQL 2137
             +  + +    +K   LK    A       A+  E    +V      +  P+KE     ++
Sbjct: 9549  AEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKV 9608

Query: 2138  KSDPVD--PDKEPEKEDVSASGPSP-EATQLAKQMELEQAVEHIAKLAEASASAAYKADA 2194
               +P    P+K+   + +    P P + T+   Q+  E+ V  +A   + +   A   + 
Sbjct: 9609  PEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKV-LVAVTKKEAPPKARVPEE 9667

Query: 2195  PEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPE---NFPAPPPYPGESQTDLQPPA 2251
             P+   PE++        E E  A +      +  E +     P   P P +  T ++   
Sbjct: 9668  PKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKE 9727

Query: 2252  GAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHS 2311
              A  L+     ++ +E      E +        P    D      + +  R    E   +
Sbjct: 9728  RAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYIT 9787

Query: 2312  VPEAKGSKEVEVTLVRKD----KGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESP 2367
              PE    K + V  V ++    K +    +  +K    +KV  P+   +        E P
Sbjct: 9788  EPE----KPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEP 9843

Query: 2368  AANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLS--KIPSTENSSQEISVEERTPTKA 2425
                    ++     +E++Q  +P +  P      ++  K+P      +E++   R P   
Sbjct: 9844  KKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPR---KEVAPPVRVP--- 9897

Query: 2426  SVPPDLPPPP-----------QPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPS 2474
              VP +L P             +   V+EE +        I  + V P     +P      
Sbjct: 9898  EVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKP 9957

Query: 2475  VTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTL 2534
             V   K   PV       ++PP KV E   + EE      P    PP  K  +V       
Sbjct: 9958  VPEEKKPVPVPK---KKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPE 10014

Query: 2535  RKILMD-PKYVSATSVTSTSVTTAIAEPVS------AAPCLHEAPP---PPVDSKKPLEE 2584
              K+ +  PK V A       V     +PV        AP   EAPP   P V  K   EE
Sbjct: 10015 EKVPVPVPKKVEA---PPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEE 10071

Query: 2585  KTAPPVTNNSEIQASEVLVAADKEKV-APVIAPKITSVI 2622
             K   PV    +++A    V   +E V  PV  P+   V+
Sbjct: 10072 KKPTPVP--KKVEAPPPKVPKKREPVPVPVALPQEEEVL 10108



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 128/550 (23%), Positives = 192/550 (34%), Gaps = 111/550 (20%)

Query: 2958  KKLADPVTLKIETKVLQPANLGSTLTPH-HPPA----LPSKLPTEVN-HVPSGPSIPADR 3011
             K  A P   +I  K++ P    + + P   PPA    +P K+  E    VP  P +P  +
Sbjct: 10435 KPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTK 10494

Query: 3012  TVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSI 3071
                 L   ++      P  P     P A  P                     VP+    +
Sbjct: 10495 VPEVLPPKEVVPEKKVPVPPAKK--PEAPPPK--------------------VPEAPKEV 10532

Query: 3072  HPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEV 3131
              PE+ V +PP                     P  P +  +  PE    P+A +  +++  
Sbjct: 10533 VPEKKVPVPP---------------------PKKPEVPPTKVPEV---PKAAVPEKKVPE 10568

Query: 3132  RAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHP--- 3188
               P +  +P P    VP    +  PE++V    P A    P  + V V ++   + P   
Sbjct: 10569 AIPPKPESPPPE---VPEAPKEVVPEKKV----PAAPPKKPEVTPVKVPEAPKEVVPEKK 10621

Query: 3189  YTVPRDVRIMVHPHVTAVSEQPRAADGVVKVP------PASKAPQ---QPGKEAAKTPDA 3239
               VP   +  V P  T V E P+ A    KVP      P S  P+   +P + A + P A
Sbjct: 10622 VPVPPPKKPEVPP--TKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPA 10679

Query: 3240  KAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSS 3299
             +    P PA  P  V +P   P P  +A  +           P  PPV V    +     
Sbjct: 10680 EVVEEPEPA-APPQVTVPPKKPVPEKKAPAVVAKK-------PELPPVKVPEVPK----- 10726

Query: 3300  GELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGP--PPEGEPLQPPQPV 3357
              E+  E +   +    P A     + P      +P +     + P  PP   P  P +PV
Sbjct: 10727 -EVVPEKKVPLVVPKKPEAP--PAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPV 10783

Query: 3358  QSTQPAQPAP----PCPPSQLGQPGQ--PPSSKMPQVSQE---AKGTQTGVEQPRLPAGP 3408
                +PA P P      PP    +P +  P     P+  +    A+  +  V  P +P  P
Sbjct: 10784 LEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEP 10843

Query: 3409  ANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDL------PVSLPTQTAPKQPLF---- 3458
                 PE    V + + E  P   P P  V  KP L      P   P +   K+ +F    
Sbjct: 10844 KKIIPEKKVPVIK-KPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKA 10902

Query: 3459  VPTTSGPSTP 3468
             +P    P  P
Sbjct: 10903 IPKKKVPEKP 10912



 Score = 66.2 bits (160), Expect = 6e-10
 Identities = 131/581 (22%), Positives = 193/581 (33%), Gaps = 82/581 (14%)

Query: 2939  PPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHH-----PPALPSK 2993
             PP  V    VL P  V   KK+  P   K E    +       + P       PP  P  
Sbjct: 10491 PPTKVPE--VLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEV 10548

Query: 2994  LPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPS--SFPRASHPSSTASTALS 3051
              PT+V  VP   ++P  +          +A  P+P  P P     P+   P      A  
Sbjct: 10549 PPTKVPEVPKA-AVPEKKVP--------EAIPPKPESPPPEVPEAPKEVVPEKKVPAAPP 10599

Query: 3052  TNATVMLAAGIPVPQFISSIHPEQSVIMPPHSI-----TQTVSLSHLSQGEVRMNTPTLP 3106
                 V     + VP+    + PE+ V +PP        T+   +  ++  E ++    +P
Sbjct: 10600 KKPEV---TPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKV-PEAIP 10655

Query: 3107  SITYSIRPEALHSPR--APLQPQQIEVRAPQRASTPQ-------PAPAG-VPALASQHPP 3156
                 S  PE    P   A  +P    V  P+ A+ PQ       P P    PA+ ++ P 
Sbjct: 10656 PKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPE 10715

Query: 3157  EEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGV 3216
                V     V +   P +   LV+  +    P  VP   + +V     AV ++P      
Sbjct: 10716 LPPVKVP-EVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPA- 10773

Query: 3217  VKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSN 3276
              KVP   K P    K A   P+   +P P     P  +  P    AP  E  +    P  
Sbjct: 10774 -KVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIA-PEEEIAPEEEKPV----PVA 10827

Query: 3277  QLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSR 3336
             + +   + PP V     +I+        E +   I+    P               L  R
Sbjct: 10828 EEEEPEVPPPAVPEEPKKII-------PEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPR 10880

Query: 3337  TKTAAQGPPPEG-----------------EPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQ 3379
                    PP E                  E  Q P+ V+ T    P       +L  P +
Sbjct: 10881 PPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKL-LPER 10939

Query: 3380  PPSSKMPQV----------SQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPT 3429
              P  K   V           +E K     +E+ + PA P   PP+P  +V+         
Sbjct: 10940 KPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRER 10999

Query: 3430  SFPSPVSV-SMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPP 3469
               P P  V  +KP +P+  P +  PK    V T   P   P
Sbjct: 11000 KIPEPTKVPEIKPAIPLPAP-EPKPKPEAEVKTIKPPPVEP 11039



 Score = 63.5 bits (153), Expect = 4e-09
 Identities = 173/848 (20%), Positives = 300/848 (35%), Gaps = 132/848 (15%)

Query: 1795 PESQPPASEDLEVDPPV-----AAKDKKP--NKSKRSKTPVQAAAVSIVEKPVTRKSERI 1847
            PE  PP      V PP+       ++KKP   + + +K  V+  A  +V KP     E  
Sbjct: 8954 PEEIPPV-----VAPPIPLLLPTPEEKKPPPKRIEVTKKAVKKDAKKVVAKP----KEMT 9004

Query: 1848 DREKLKRSNSPR-----GEAQKLLELKMEAEKI---TRTASKNSAADLEHPEPSLPLSRT 1899
             RE++ +   P       +A +++++  +AE++   T T  K    + E           
Sbjct: 9005 PREEIVKKPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHK 9064

Query: 1900 RRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRR 1959
             +R     +    D     P  EP EQP       + E  +  A             ++ 
Sbjct: 9065 EKRVFIESFEEPYDELEVEPYTEPFEQPYYEEPDEDYEEIKVEA-------------KKE 9111

Query: 1960 ADEEEENEAKEPAETLKPPEG-------WRSPRSQKTAAGGGPQGKKGKNEPKVDATRPE 2012
              EE E + +E  E  +  EG       W     ++       +  +  +E KV A  PE
Sbjct: 9112 VHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKVPE 9171

Query: 2013 ATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKN 2072
                  P++ +K+  +E            K ++     ++   +   V  V KK  P+K 
Sbjct: 9172 KKAPPPPKV-IKKPVIE------------KIEKTSRRMEEEKVQVTKVPEVSKKIVPQKP 9218

Query: 2073 SKS---------KRGRSRNSRLAVDKS----ASLKNVDAAVSPRGAAAQAGERESGVVAV 2119
            S++         K       ++ + +     AS    + +V+      +    E   VA+
Sbjct: 9219 SRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAI 9278

Query: 2120 SPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQA----V 2175
            S ++ E P K   L  +   + V P   P+K +     P+P+  ++ K+   E+     V
Sbjct: 9279 S-KRVEPPPKVPELPEKPAPEEVAPVPIPKKVEP----PAPKVPEVPKKPVPEEKKPVPV 9333

Query: 2176 EHIAKLAEASASAAYKADAPEGLAP----EDRDKPAHQASETELAAAIGSIINDISGEPE 2231
                  A        K   PE   P    + ++ P  +  E +        I  ++   E
Sbjct: 9334 PKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREE 9393

Query: 2232 NFP-APPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPV---- 2286
            + P A P  P +   + + P   +     EE +     V  + +     E    PV    
Sbjct: 9394 SPPPAVPEIPKKKVPEERKPVPRK-----EEEVPPPPKVPALPKKPVPEEKVAVPVPVAK 9448

Query: 2287 NAPDPSAG---PTDTKEARGNSSET-SHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKR 2342
             AP P A     T  +E R  + E  S +VP+      VEVT       R + +      
Sbjct: 9449 KAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQ-----RVEVT-------RHEVSAEEEWS 9496

Query: 2343 NTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDL 2402
             + ++    +  +  E  + + E+    E T  +  E P+E    EK H     S   + 
Sbjct: 9497 YSEEEEGVSISVYREEEREEEEEA----EVTEYEVMEEPEEYVVEEKLHII---SKRVEA 9549

Query: 2403 SKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPP 2462
                 TE   ++I ++ + P K   PP    P  P  +  E +    V    +  P   P
Sbjct: 9550 EPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVP 9609

Query: 2463 SDPSIPIPTLPSVTAAKLSPPVASGGIPHQSP-PTKVTE---WITRQEEPRAQSTPSPAL 2518
             +P  P+P        K+ P V    I  + P P KVTE    IT++E+     T   A 
Sbjct: 9610 EEPKKPVP------EKKVPPKV----IKMEEPLPAKVTERHMQITQEEKVLVAVTKKEA- 9658

Query: 2519 PPDTKASDVDTSSSTLRKIL-MDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVD 2577
            PP  +  +    +    K+L + PK         T     + +    +    +  P P+ 
Sbjct: 9659 PPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIK 9718

Query: 2578 SKKPLEEK 2585
                +EEK
Sbjct: 9719 EVTIMEEK 9726



 Score = 63.2 bits (152), Expect = 5e-09
 Identities = 143/676 (21%), Positives = 229/676 (33%), Gaps = 145/676 (21%)

Query: 2836  QIPPASAMDIEFQQSV--SKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTY 2893
             ++PP    ++   + V   K    P +     PP K P+AP                   
Sbjct: 10489 RVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAP------------------- 10529

Query: 2894  NASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSI 2953
                 V+   K   P  +KPE     V          K + + I   P     ++   P  
Sbjct: 10530 --KEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKE 10587

Query: 2954  VTTNKKLADPVTLKIETKVLQPANLGSTLTPHH-----PPALPSKLPTEVNHVPSGPSIP 3008
             V   KK+      K E   ++       + P       PP  P   PT+V  VP   ++P
Sbjct: 10588 VVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPK-VAVP 10646

Query: 3009  ADRTVSHLAAAKLDAHSPRPSGPGPSSF------------------------PRASHPSS 3044
               +          +A  P+P  P P  F                        P+ + P  
Sbjct: 10647 EKKVP--------EAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPK 10698

Query: 3045  TASTALSTNATVMLAAGIP---VPQFISSIHPEQSV--IMPPHSITQTVSLSHLSQG--- 3096
                      A V     +P   VP+    + PE+ V  ++P         +  + +    
Sbjct: 10699 KPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVP 10758

Query: 3097  EVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPP 3156
             E ++  P  P +  +  PE    P+ P+  ++  V  P+RA +P P     P    +  P
Sbjct: 10759 EKKVAVPKKPEVPPAKVPEV---PKKPVLEEKPAVPVPERAESPPPEVYEEP---EEIAP 10812

Query: 3157  EEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGV 3216
             EEE+    P      PV  E      E  + P  VP + + ++      V ++P A    
Sbjct: 10813 EEEI---APEEEKPVPVAEE-----EEPEVPPPAVPEEPKKIIPEKKVPVIKKPEA---- 10860

Query: 3217  VKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARI--LTVTP 3274
                PP    P++P  E       K    P   P P P P PAP P    + +I  L   P
Sbjct: 10861 ---PP----PKEPEPE-------KVIEKPKLKPRPPPPP-PAP-PKEDVKEKIFQLKAIP 10904

Query: 3275  SNQLQGLPLTP------PVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAA 3328
               ++   P  P      P+ V  G + V    +L  E      R   P  ++        
Sbjct: 10905 KKKVPEKPQVPEKVELTPLKVPGGEKKVR---KLLPE------RKPEPKEEVV------- 10948

Query: 3329  SSVGLPSRTKTAAQGPPPEGEPLQPPQPVQST-QPAQPAPPCPPSQLGQPGQPPSSKMPQ 3387
                      K+  +  P E EP   P+ ++   +PA P PP PP  + +   P  +K  +
Sbjct: 10949 --------LKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPP-PPKPVEEVEVPTVTKRER 10999

Query: 3388  VSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQ---AETGPTSFPSPVSVSM---KP 3441
                E   T+    +P +P       P+P  +V+  +    E  PT   +PV+V +   K 
Sbjct: 11000 KIPEP--TKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKA 11057

Query: 3442  DLPVSLPTQTAPKQPL 3457
             +          PK P+
Sbjct: 11058 EAKAPKEEAAKPKGPI 11073



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 133/642 (20%), Positives = 205/642 (31%), Gaps = 112/642 (17%)

Query: 2907  PSLEKPEPIHLSV--STPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPV 2964
             P  EKP P  +      PV +      + + +  PP  V       P      KK+  P 
Sbjct: 9994  PKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPE----VPKKPVPEKKVPVPA 10049

Query: 2965  TLKIET---------KVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSH 3015
               K+E          K L P     T  P    A P K+P +   VP   ++P +  V  
Sbjct: 10050 PKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLF 10109

Query: 3016  LAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQ 3075
                            P     P            L     V+             I PE+
Sbjct: 10110 ----------EEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEE--------EEIPPEE 10151

Query: 3076  SVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQ 3135
               + P              + E       LP +   + P     P    +  + +V  P+
Sbjct: 10152 EEVPPEEEYVP-------EEEEFVPEEEVLPEVKPKV-PVPAPVPEIKKKVTEKKVVIPK 10203

Query: 3136  RASTPQPAPAGVPALASQH----PPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTV 3191
             +   P      VP    +     P EEEV   LPV     P   E  + + E    P ++
Sbjct: 10204 KEEAPPAKVPEVPKKVEEKRIILPKEEEV---LPVEVTEEP--EEEPISEEEIPEEPPSI 10258

Query: 3192  PRDVRIMVHPHVT-----AVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPT 3246
               +V  +  P V      AV E P      V+ PPA  + + P ++       K AP   
Sbjct: 10259 -EEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAK 10317

Query: 3247  PAPVPVPVP-----LPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQI------ 3295
                VP  VP     +P     P  + R    T   +   +     VVV   +++      
Sbjct: 10318 VPEVPKKVPEKKVLVPKKEAVPPAKGR----TVLEEKVSVAFRQEVVVKERLELEVVEAE 10373

Query: 3296  ---------VHSSGELFQEYRYGDIRTY----------HPPAQLTHTQFPA--ASSVGLP 3334
                       H   E F+E  + ++  +              +  H       A  V + 
Sbjct: 10374 VEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVF 10433

Query: 3335  SRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPP---------SQLGQPGQP--PSS 3383
              + K   +GP    + + P +P     P +  P   P          ++  P +P  P +
Sbjct: 10434 EKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPT 10493

Query: 3384  KMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDL 3443
             K+P+V       +  V + ++P  PA +P  P  +V  A  E  P     PV    KP++
Sbjct: 10494 KVPEVLP----PKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEK-KVPVPPPKKPEV 10548

Query: 3444  PVSLPTQTAPKQPLFVPTTSGP-STPPGLVLPHTEFQPAPKQ 3484
             P   PT+        VP    P + PP    P  E   APK+
Sbjct: 10549 P---PTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKE 10587



 Score = 57.8 bits (138), Expect = 2e-07
 Identities = 92/407 (22%), Positives = 153/407 (37%), Gaps = 47/407 (11%)

Query: 3113  RPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAP 3172
             R E +H      + +++EV    +A  P+        +  + PP + V    P A+   P
Sbjct: 10414 RVEKVHRVIEVFEAEEVEVFEKPKAP-PKGPEISEKIIPPKKPPTKVVPRKEPPAKV--P 10470

Query: 3173  VQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGK- 3231
                + +V++ + R     VP + R+        +  +    +  V VPPA K    P K 
Sbjct: 10471 EVPKKIVVEEKVR-----VPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKV 10525

Query: 3232  -EAAK--TPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVV 3288
              EA K   P+ K    P   P   P  +P    A   E ++    P       P +PP  
Sbjct: 10526 PEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPK-----PESPPP- 10579

Query: 3289  VTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEG 3348
                  ++  +  E+  E +        P  ++T  + P A    +P +         PE 
Sbjct: 10580 -----EVPEAPKEVVPEKKVPAAPPKKP--EVTPVKVPEAPKEVVPEKKVPVPPPKKPEV 10632

Query: 3349  EPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGP 3408
              P + P+  +   P +  P   P +       P S  P+V +E +  +  +E+P  PA  
Sbjct: 10633 PPTKVPEVPKVAVPEKKVPEAIPPK-------PESPPPEVFEEPE--EVALEEP--PAEV 10681

Query: 3409  ANRP-PEPHTQVQRAQAETGPTSFPSPVSVSMKPDLP----VSLPTQTAP--KQPLFVPT 3461
                P P    QV     +  P    +P  V+ KP+LP      +P +  P  K PL VP 
Sbjct: 10682 VEEPEPAAPPQVTVPPKKPVPEK-KAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVP- 10739

Query: 3462  TSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRPVDMVQLLKKYPIV 3508
                P  PP  V P    +  P++  +     + P   V  + K P++
Sbjct: 10740 -KKPEAPPAKV-PEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVL 10784



 Score = 53.5 bits (127), Expect = 4e-06
 Identities = 201/1068 (18%), Positives = 353/1068 (33%), Gaps = 177/1068 (16%)

Query: 1699 QVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQP 1758
            +++L P   PD    +    +      + PP +   PP P          + P P+  +P
Sbjct: 8929 KLELKPPDIPDSRVPIPTMPIRAVPPEEIPPVV--APPIP---------LLLPTPEEKKP 8977

Query: 1759 LSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKP 1818
              K  + +++A +  A+K      A+P      E   +  PP +  +    P        
Sbjct: 8978 PPKRIEVTKKAVKKDAKK----VVAKPKEMTPREEIVKKPPPPTTLIPAKAPEIIDVSSK 9033

Query: 1819 NKSKRSKTPVQAAAVSIVEKPVTRKSERIDREK---LKRSNSPRGEA------------- 1862
             +  +  T  +   V   ++ V  K + + +EK   ++    P  E              
Sbjct: 9034 AEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQPY 9093

Query: 1863 -----QKLLELKMEAEKITRTASKNSAAD----------LEHPEPSLPLSRTRRRNV--- 1904
                 +   E+K+EA+K      +    +           +  E     +   R  +   
Sbjct: 9094 YEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQ 9153

Query: 1905 RSVYATMGDHENRSPVKEP---------------VEQPRVTRKRLERELQEAAAVPTTPR 1949
            + VY     HE + P K P               +E+   T +R+E E  +   VP   +
Sbjct: 9154 KEVYEE--SHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSK 9211

Query: 1950 RGRPPKTRRRADEEEENEAKEPA-----ETLKPPEGWRSPRSQKTAAGGGPQGKKG-KNE 2003
            +  P K  R   +EE  E K PA       +   + + +  +++  +   P+ +K    E
Sbjct: 9212 KIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTE 9271

Query: 2004 PKVD---ATRPEATTEVGPQIGVKESSME------PKAAEEEAGSEQKRDRKDAGTDKNP 2054
             K+    + R E   +V P++  K +  E      PK  E  A    +  +K    +K P
Sbjct: 9272 EKIHVAISKRVEPPPKV-PELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKP 9330

Query: 2055 ---PETAP-----VEVVEKKPAPEKNSKSKRGRSRNSRLA----VDKSASLKNVDAAVSP 2102
               P+  P     V  V KKP PE+       + + +  A    V K    +     V+ 
Sbjct: 9331 VPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQ 9390

Query: 2103 RGAAAQAGERESGVVAVSPEKSESPQKEDGLS-----SQLKSDPVDPDKEPEKEDVSASG 2157
            R  +      E     V  E+   P+KE+ +        L   PV  +K      V+   
Sbjct: 9391 REESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKA 9450

Query: 2158 PSPEATQLAKQMELEQAVEHIAKLA------------EASASAAYK-ADAPEGLA----- 2199
            P P A    K +  E+      KL+            E SA   +  ++  EG++     
Sbjct: 9451 PPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYR 9510

Query: 2200 ------PEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGA 2253
                   E+ +   ++  E      +   ++ IS   E  PA      E +  L+P   A
Sbjct: 9511 EEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPA 9570

Query: 2254 QALQPSEEGMETDEAVSGILETE-----AATESSRPPVNAPDPSAGPTDTKEARGNSSET 2308
            +  +P     +  EA   I+  +        +   PP   P+    P   K+      + 
Sbjct: 9571 KIEEPPP--AKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKM 9628

Query: 2309 SHSVPEAKGSKEVEVTLVRK--DKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGES 2366
               +P     + +++T   K      +K    + +     K   P E  +    + + E 
Sbjct: 9629 EEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEP 9688

Query: 2367 PAANEGTTVQHPEAPQEEK---QSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPT 2423
            PA     T       +EEK   ++ K    P +  T    K  +     + +SV+     
Sbjct: 9689 PAK---VTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEY 9745

Query: 2424 KASVPPDLPPPPQPAPVDEEPQ---------ARFRVHSIIESDPVTP---PSDPSIPIPT 2471
            +     D     +  P +E  Q          R+  H    ++P  P      P  P+PT
Sbjct: 9746 EEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPT 9805

Query: 2472 LPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTK-------- 2523
             P    AK    V    +P +  P  +         P+    P P +P + K        
Sbjct: 9806 KPKAPPAK----VLKKAVPEEKVPVPI---------PKKLKPPPPKVPEEPKKVFEEKIR 9852

Query: 2524 ----ASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSK 2579
                  + +  +    K+ M PK V A           +A PV       E  P  V  +
Sbjct: 9853 ISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVP-RKEVAPPVRVPEVPKELEPEEVAFE 9911

Query: 2580 KPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPV 2627
            + +       +    E    E      +E+V PVI  K+  V  R PV
Sbjct: 9912 EEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEV-PRKPV 9958



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 74/394 (18%), Positives = 134/394 (34%), Gaps = 40/394 (10%)

Query: 3108 ITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVA 3167
            I   + P A   P  P +P   E +          AP  VP +  +  PEE++   +PVA
Sbjct: 9305 IPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIP--VPVA 9362

Query: 3168 RATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQ 3227
            +      ++V  +Q               ++    +T V+++  +    V   P  K P+
Sbjct: 9363 KKKEAPPAKVPEVQKG-------------VVTEEKITIVTQREESPPPAVPEIPKKKVPE 9409

Query: 3228 Q----PGKEAAKTPDAKAAPTPT-PAP---VPVPVPLPAPAPAPHGEARILTVTPSNQLQ 3279
            +    P KE    P  K    P  P P   V VPVP+   AP P  E    TV    +  
Sbjct: 9410 ERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFV 9469

Query: 3280 GLPLTPPVVVTHGVQIVHSSGELFQEYRYGD------IRTYHPPAQLTHTQFPAASSVGL 3333
                     V   V++        +E+ Y +      I  Y    +    +        +
Sbjct: 9470 AEEKL-SFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVM 9528

Query: 3334 PSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAK 3393
                +   +            +P + T+  +      P    +  +PP +K+P+  ++  
Sbjct: 9529 EEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKI- 9587

Query: 3394 GTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLP---TQ 3450
                 V + ++PA    +   P  +V     +  P     P  + M+  LP  +     Q
Sbjct: 9588 -----VPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQ 9642

Query: 3451 TAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQ 3484
               ++ + V  T     PP   +P    +  P++
Sbjct: 9643 ITQEEKVLVAVTK-KEAPPKARVPEEPKRAVPEE 9675



 Score = 46.6 bits (109), Expect = 5e-04
 Identities = 78/312 (25%), Positives = 116/312 (37%), Gaps = 59/312 (18%)

Query: 3073 PEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVR 3132
            P   VI  P  + + +  +     E ++    +P ++  I P+     R P+Q + IEV+
Sbjct: 9176 PPPKVIKKP--VIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQK--PSRTPVQEEVIEVK 9231

Query: 3133 APQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVP 3192
             P    T +   +      + H  EEEV   +P       VQ E++   +E ++H   V 
Sbjct: 9232 VPA-VHTKKMVISEEKMFFASHT-EEEVSVTVP------EVQKEIV---TEEKIH---VA 9277

Query: 3193 RDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPA-PVP 3251
               R+   P V  + E+P A + V  VP     P++    A K P+    P P    PVP
Sbjct: 9278 ISKRVEPPPKVPELPEKP-APEEVAPVP----IPKKVEPPAPKVPEVPKKPVPEEKKPVP 9332

Query: 3252 VPVPLPAPAPA-------PHGEARILTVTPSNQLQGLPLTPP-----VVVTHGVQIVHSS 3299
            VP   PA  P        P  E +I  V  + + +  P   P     VV    + IV   
Sbjct: 9333 VPKKEPAAPPKVPEVPKKPVPEEKI-PVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQR 9391

Query: 3300 GELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQG----PPPEGEPLQPPQ 3355
             E              PPA       P      +P   K   +     PPP   P  P +
Sbjct: 9392 EES------------PPPA------VPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKK 9433

Query: 3356 PVQSTQPAQPAP 3367
            PV   + A P P
Sbjct: 9434 PVPEEKVAVPVP 9445



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 68/289 (23%), Positives = 106/289 (36%), Gaps = 23/289 (7%)

Query: 2897 PVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVL-----VHNQLVLTP 2951
            PVI  ++     +E+ E + ++    V++    K++ Q  +  PV      V    V T 
Sbjct: 9184 PVIEKIEKTSRRMEE-EKVQVTKVPEVSK----KIVPQKPSRTPVQEEVIEVKVPAVHTK 9238

Query: 2952 SIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADR 3011
             +V + +K+      + E  V  P      +T        SK       VP  P  PA  
Sbjct: 9239 KMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPE 9298

Query: 3012 TVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSI 3071
             V+ +   K       P  P     P+   P       +        AA   VP+     
Sbjct: 9299 EVAPVPIPK----KVEPPAPKVPEVPKKPVPEEKKPVPVPKKEP---AAPPKVPEVPKKP 9351

Query: 3072 HPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQI-- 3129
             PE+ + +P   + +          EV+    T   IT   + E    P  P  P++   
Sbjct: 9352 VPEEKIPVP---VAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVP 9408

Query: 3130 EVRAP-QRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEV 3177
            E R P  R     P P  VPAL  +  PEE+V   +PVA+   P ++EV
Sbjct: 9409 EERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEV 9457



 Score = 42.0 bits (97), Expect = 0.011
 Identities = 128/610 (20%), Positives = 237/610 (38%), Gaps = 97/610 (15%)

Query: 656   EFYSEWETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDR 715
             E Y E+E Y  DY E   Y+   EY     D YE    EY  R+ ER  E E + ++ ++
Sbjct: 9743  EEYEEYEEY--DYKEFEEYEPTEEY-----DQYE----EYEEREYERYEEHEEYITEPEK 9791

Query: 716   DHERRPIERSQSPVHLRRPQSPGASPSQ----AERLPSDSERRLYSRSSDRSGSCSSLSP 771
                 +P+     P    +P++P A   +     E++P    ++L               P
Sbjct: 9792  PIPVKPVPEEPVPT---KPKAPPAKVLKKAVPEEKVPVPIPKKL------------KPPP 9836

Query: 772   PRYEKLDKSRLERYTKNE--KTDKERTFDP--ERVERERRLIRKEKVEKDKTDKQKRKGK 827
             P+  +  K   E   +    K +KE+  +P  +   + +R++ +EKV   +        K
Sbjct: 9837  PKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPR--------K 9888

Query: 828   VHSPSSQSSETDQENEREQSPEKPRSCNKL-------SREKADKEGIAKNRLELMPCVVL 880
               +P  +  E  +E E E+   +      +         E   +E       E++P V+ 
Sbjct: 9889  EVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVP-VIP 9947

Query: 881   TRVKEKEGKVIDH----TPVEKLK----AKLDNDTVKSSALDQKLQVSQTEPAKSDLSKL 932
              +V E   K +       PV K K    AK+     K    ++K+ V   +  K   +K+
Sbjct: 9948  VKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKP---EEKVPVLIPKKEKPPPAKV 10004

Query: 933   ESVRMK-VPKEKGLSSHVEVVEKEGRLKARKHLKPEQPA--DGVSAVDLEKLEARKRRFA 989
               V  K VP+EK     V V +K     A+    P++P     V     +K+EA   +  
Sbjct: 10005 PEVPKKPVPEEK---VPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVP 10061

Query: 990   D--SNLKAEKQKPEVKKSSPEMEDARVLSKKQP-----DVSSREVILLRE---GEAERKP 1039
             +    L  E++KP       E    +V  K++P      +   E +L  E    E E  P
Sbjct: 10062 EVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLP 10121

Query: 1040  VRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVENQ 1099
               +E+L  E + +  +        +   E   +       P  +      E   E     
Sbjct: 10122 EEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVP------PEEEYVPEEEEFVPEEEVLP 10175

Query: 1100  EVQSKKPIPSK-PQLKQLQVLDDQG--PEREDVRKNYCSLRDETPERKSGQEKSHSVNTE 1156
             EV+ K P+P+  P++K+ +V + +   P++E+          + PE     E+   +  +
Sbjct: 10176 EVKPKVPVPAPVPEIKK-KVTEKKVVIPKKEEAPP------AKVPEVPKKVEEKRIILPK 10228

Query: 1157  EKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQ 1216
             E+  + ++ T+   ++        +    I + E+   P+  V E  ++++       P+
Sbjct: 10229 EEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPR--VPEVIKKAVPEAPTPVPK 10286

Query: 1217  DVTDDSPPSK 1226
              V  ++PP+K
Sbjct: 10287 KV--EAPPAK 10294



 Score = 41.2 bits (95), Expect = 0.019
 Identities = 67/346 (19%), Positives = 122/346 (35%), Gaps = 66/346 (19%)

Query: 2836  QIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNA 2895
             + PPA   ++  +    K    P       PP+K P+ P             L  +    
Sbjct: 10026 EAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPK-----------KLIPEEKKP 10074

Query: 2896  SPVISSVKADRPSL-EKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIV 2954
             +PV   V+A  P + +K EP+ + V+ P  +                    +++    IV
Sbjct: 10075 TPVPKKVEAPPPKVPKKREPVPVPVALPQEE--------------------EVLFEEEIV 10114

Query: 2955  TTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPS-IPADRTV 3013
                + L +   +  E + + P            P    ++P E  +VP     +P +  +
Sbjct: 10115 PEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVL 10174

Query: 3014  SHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHP 3073
               +          +P  P P+  P      +     +        A    VP+ +     
Sbjct: 10175 PEV----------KPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVE---- 10220

Query: 3074  EQSVIMP------PHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQ 3127
             E+ +I+P      P  +T+      +S+ E+    P++  +      E +  PR P    
Sbjct: 10221 EKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEV------EEVAPPRVP---- 10270

Query: 3128  QIEVRAPQRASTPQPAPA-GVPALASQHPPEEEVHYHLPVARATAP 3172
             ++  +A   A TP P      PA  S+  PEE+V   +PV +  AP
Sbjct: 10271 EVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKV--PVPVQKKEAP 10314



 Score = 40.8 bits (94), Expect = 0.025
 Identities = 82/410 (20%), Positives = 132/410 (32%), Gaps = 42/410 (10%)

Query: 2909  LEKPEP-----IHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADP 2963
             +E+PEP     + +    PV +     V+ +    PPV V       P  V   KK+   
Sbjct: 10682 VEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPE----VPKEVVPEKKVPLV 10737

Query: 2964  VTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDA 3023
             V  K E    +   +   + P    A+P K       VP  P  P       +   +   
Sbjct: 10738 VPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPE--- 10794

Query: 3024  HSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAG----IP---VPQFISSIHPEQS 3076
                R   P P  +      +     A      V +A      +P   VP+    I PE+ 
Sbjct: 10795 ---RAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKK 10851

Query: 3077  VIM------PPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIE 3130
             V +      PP    +   +    + + R   P        ++ +       P +    +
Sbjct: 10852 VPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEK 10911

Query: 3131  VRAPQRAS-TPQPAPAG---VPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEY-- 3184
              + P++   TP   P G   V  L  +  PE +    L       P + E  V   +   
Sbjct: 10912 PQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEK 10971

Query: 3185  -RLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAP 3243
              +      P   + +    V  V+++ R      KVP    A   P  E    P+A+   
Sbjct: 10972 VKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKT 11031

Query: 3244  TPTPAPVPVPVPLPAPAPAP----HGEARI---LTVTPSNQLQGLPLTPP 3286
                P   P P P+ AP   P      EA+        P   ++G+P   P
Sbjct: 11032 IKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTP 11081



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 106/564 (18%), Positives = 209/564 (37%), Gaps = 63/564 (11%)

Query: 771  PPRYEKLDKSRLERYTKNEKTDKERTFD-PERVERERRLIRKEKVEKDKTDKQKRKGKVH 829
            PPR E   K+ +E   K    +++ +F  P+RVE  R  +  E+      +++     V+
Sbjct: 9452 PPRAEVSKKTVVEE--KRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVY 9509

Query: 830  SPSSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGK 889
                +  E + E    +  E+P           +K  I   R+E  P      V E++ K
Sbjct: 9510 REEEREEEEEAEVTEYEVMEEPEEY-----VVEEKLHIISKRVEAEPA----EVTERQEK 9560

Query: 890  VIDHTPVEKLKAKLDN-------DTVKSSALDQKLQVSQTEPAKSDLSKL-ESVRMKVPK 941
             I   P  K+ AK++        +  K    ++K+     +  K    K+ E  +  VP+
Sbjct: 9561 KIVLKP--KIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPE 9618

Query: 942  EKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPE 1001
            +K     +++ E        +H++  Q    + AV  ++   + R   +      ++K  
Sbjct: 9619 KKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVL 9678

Query: 1002 VKKSSPEMEDARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVA 1061
              K   E E    +++ +  V   E + +   + E +P+++  +  E ++        V+
Sbjct: 9679 KLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVS 9738

Query: 1062 SPK----------DCQELASISVGSGSRPSSDLQARLGELAGESVENQEVQSK------- 1104
              +          D +E              + + R  E   E  E      K       
Sbjct: 9739 VQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPV 9798

Query: 1105 --KPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGID 1162
              +P+P+KP+    +VL    PE +        L+   P+     +K      EEKI I 
Sbjct: 9799 PEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVF----EEKIRIS 9854

Query: 1163 IDHTQSYRKQMEQSRRKQQME-MEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDD 1221
            I  T+  ++Q+ +   K  M+   +   EK   P+K+V    R      V + P+++  +
Sbjct: 9855 I--TKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVR------VPEVPKELEPE 9906

Query: 1222 SPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTG----GSPSVRHGSFHEDEDPIG 1277
                +++ + HV+  +  + E       +   + E         P V      E++ P+ 
Sbjct: 9907 EVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVP 9966

Query: 1278 SPRL-----LSVKGSPKVDEKVLP 1296
             P+        V   PK  E+ +P
Sbjct: 9967 VPKKKEAPPAKVPEVPKKPEEKVP 9990



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 74/383 (19%), Positives = 131/383 (34%), Gaps = 67/383 (17%)

Query: 3115 EALH--SPRAPLQPQQIEVRAPQR--------ASTPQPAPAGVPALASQHPPEEEVHYHL 3164
            E LH  S R   +P ++  R  ++        A   +P PA VP    +  PE++V   +
Sbjct: 9538 EKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPV 9597

Query: 3165 PVARATAP--VQSEVLVMQSEYRLHPYTVPRD--VRIMVHPHVTAVSEQPRAADGVVK-- 3218
            P      P  V  E      E ++ P  +  +  +   V      ++++ +    V K  
Sbjct: 9598 PKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKE 9657

Query: 3219 VPPASKAPQQPGKEAAKTPDAKAAP---TPTPAPV-----------PVPVPLPAPAPAPH 3264
             PP ++ P++P +   +    K  P      PA V            V +  P   P P 
Sbjct: 9658 APPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPI 9717

Query: 3265 GEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQL---- 3320
             E  I+      + +   L    V            E ++EY Y +   Y P  +     
Sbjct: 9718 KEVTIM----EEKERAYTLEEEAVSVQR----EEEYEEYEEYDYKEFEEYEPTEEYDQYE 9769

Query: 3321 -----------THTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPC 3369
                        H ++       +P   K   + P P      P + ++   P +  P  
Sbjct: 9770 EYEEREYERYEEHEEYITEPEKPIP--VKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVP 9827

Query: 3370 PPSQLGQPGQPPSSKMPQ-----VSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQA 3424
             P +L    +PP  K+P+       ++ + + T  E+ ++    A  P +P   V   + 
Sbjct: 9828 IPKKL----KPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKV 9883

Query: 3425 ETGPTSFPSPVSVSMKPDLPVSL 3447
                     PV V   P++P  L
Sbjct: 9884 PVPRKEVAPPVRV---PEVPKEL 9903



 Score = 36.6 bits (83), Expect = 0.47
 Identities = 82/380 (21%), Positives = 138/380 (36%), Gaps = 52/380 (13%)

Query: 2019 PQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRG 2078
            P+I  K  S  P      A ++  R +  +    +P   +PV  V         S S   
Sbjct: 255  PRIPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSP---SPVRHVRAPTPSPVRSVSPAA 311

Query: 2079 RSRNSRLAVDKSASL-KNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGL--SS 2135
            R   S +   +S  L +   A+    G       ++ G VA S   SE+  +E  L  S+
Sbjct: 312  RISTSPIRSVRSPLLMRKTQASTVATGPEVPPPWKQEGYVASS---SEAEMRETTLTTST 368

Query: 2136 QLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAP 2195
            Q++++     +   +E V+ SG +  A                   A  SASA+Y A+A 
Sbjct: 369  QIRTEERWEGRYGVQEQVTISGAAGAA-------------------ASVSASASYAAEAV 409

Query: 2196 EGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQA 2255
               A E +      A+   + AA+     D++   E     P      QT  +    A  
Sbjct: 410  ATGAKEVKQDADKSAAVATVVAAV-----DMARVRE-----PVISAVEQTAQRTTTTAVH 459

Query: 2256 LQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEA 2315
            +QP++E +  +   + + +   A + ++            + TKE      E  H V   
Sbjct: 460  IQPAQEQVRKEAEKTAVTKVVVAADKAK-------EQELKSRTKEVITTKQEQMH-VTHE 511

Query: 2316 KGSKEVEVTLVRK-----DKGRQKTTR-SRRKRNTNKKVVAPVESHVPESNQAQGESPAA 2369
            +  KE E T V K      K +++ TR S       K+V         E   A     A 
Sbjct: 512  QIRKETEKTFVPKVVISAAKAKEQETRISEEITKKQKQVTQEAIRQETEITAASMVVVAT 571

Query: 2370 NEGTTVQHPEAPQEEKQSEK 2389
             + T ++     QEE  +++
Sbjct: 572  AKSTKLETVPGAQEETTTQQ 591



 Score = 35.8 bits (81), Expect = 0.80
 Identities = 71/340 (20%), Positives = 116/340 (34%), Gaps = 77/340 (22%)

Query: 3174 QSEVLVMQSEY--RLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGK 3231
            + EV+ +Q E     H   VP  V     P    V ++P     + K+   S+  ++   
Sbjct: 9146 EREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPV----IEKIEKTSRRMEEEKV 9201

Query: 3232 EAAKTPDAKAAPTPT-PAPVPVPVP-LPAPAPAPHGEARILTVTP----SNQLQGLPLTP 3285
            +  K P+      P  P+  PV    +    PA H +  +++       S+  + + +T 
Sbjct: 9202 QVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTV 9261

Query: 3286 P-----VVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVG---LPSRT 3337
            P     +V    + +  S             R   PP      + PA   V    +P + 
Sbjct: 9262 PEVQKEIVTEEKIHVAISK------------RVEPPPKVPELPEKPAPEEVAPVPIPKKV 9309

Query: 3338 KTAAQGPPPEGEPLQPPQPVQSTQPAQPA----PPCPPSQLGQPGQP-PSSKMP------ 3386
            +     PP    P  P +PV   +   P     P  PP     P +P P  K+P      
Sbjct: 9310 E-----PPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKK 9364

Query: 3387 ------QVSQEAKGTQTGVE-----------QPRLPAGPANRPPEPHTQVQRAQAETGPT 3429
                  +V +  KG  T  +            P +P  P  + PE    V R + E  P 
Sbjct: 9365 KEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPP- 9423

Query: 3430 SFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPP 3469
                       P +P +LP +  P++ + VP       PP
Sbjct: 9424 ----------PPKVP-ALPKKPVPEEKVAVPVPVAKKAPP 9452



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 70/365 (19%), Positives = 127/365 (34%), Gaps = 37/365 (10%)

Query: 1618 KTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGD-KTVEAPLVTEEKTVEP 1676
            KTP   P    S   TPPS+   +   +  + +PS +  +    + V AP  +  ++V P
Sbjct: 252  KTPPRIPPKPKSRSPTPPSIA--AKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSP 309

Query: 1677 ATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPP 1736
            A     +   S  +P  + +              +A+ +  G E      Q  Y+     
Sbjct: 310  AARISTSPIRSVRSPLLMRK-------------TQASTVATGPEVPPPWKQEGYV----- 351

Query: 1737 TPGASFSQAESNVDPEPDSTQPLSKP-------AQKSEEANEPKAEKPDATADAEPDANQ 1789
               AS S+AE        STQ  ++         Q+    +         +A A   A  
Sbjct: 352  ---ASSSEAEMRETTLTTSTQIRTEERWEGRYGVQEQVTISGAAGAAASVSASASYAAEA 408

Query: 1790 KAEAAPESQPPASEDLEVDPPVAAKD----KKPNKSKRSKTPVQAAAVSIVEKPVTRKSE 1845
             A  A E +  A +   V   VAA D    ++P  S   +T  +    ++  +P   +  
Sbjct: 409  VATGAKEVKQDADKSAAVATVVAAVDMARVREPVISAVEQTAQRTTTTAVHIQPAQEQVR 468

Query: 1846 RIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVR 1905
            +   +          +  K  ELK   +++  T  K     + H +      +T    V 
Sbjct: 469  KEAEKTAVTKVVVAADKAKEQELKSRTKEVITT--KQEQMHVTHEQIRKETEKTFVPKVV 526

Query: 1906 SVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEE 1965
               A   + E R   +   +Q +VT++ + +E +  AA        +  K       +EE
Sbjct: 527  ISAAKAKEQETRISEEITKKQKQVTQEAIRQETEITAASMVVVATAKSTKLETVPGAQEE 586

Query: 1966 NEAKE 1970
               ++
Sbjct: 587  TTTQQ 591



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 38/163 (23%), Positives = 65/163 (39%), Gaps = 18/163 (11%)

Query: 1104  KKPIPSKPQLKQLQVLDDQGPERE----DVRKNYCSLRDETPERKSGQEKSHSVNTEEKI 1159
             + P  SK    ++ VLD  GP R+    ++RK+ C L  + P    G   ++ V     +
Sbjct: 17292 ENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDV 17351

Query: 1160  GIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVT 1219
                   +  +      S++K      + +  ++       ++Y R   V E  KP + + 
Sbjct: 17352 A-----SAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFV-ETPKPIKALD 17405

Query: 1220  DDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSP 1262
                PP   K + HVD D   K E +      +    +R GGSP
Sbjct: 17406 PLHPPGPPKDLHHVDVD---KTEVSL-----VWNKPDRDGGSP 17440


>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis critical
            region 1 [Homo sapiens]
          Length = 1400

 Score =  108 bits (270), Expect = 1e-22
 Identities = 257/1325 (19%), Positives = 449/1325 (33%), Gaps = 162/1325 (12%)

Query: 1602 QKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDK 1661
            Q+P E+ K  +     +   +   +K ++  T  S      +      AP   E+ + ++
Sbjct: 131  QRPPELPKSTEIHEQKRHCNTTRHSKPTDKPTGNSKTIDHKSSTDNHEAPPTSEENSSNQ 190

Query: 1662 TVEAPLVTEEKTVEPA---TVSEEAKPASEPAPAPVEQLEQVDLPPGADP-----DKEAA 1713
              + P++  +++V+PA   T  +E+       PAP  ++       G        DK   
Sbjct: 191  GKD-PMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKINCRKSTTGKSTVTRKSDKTGR 249

Query: 1714 MMPAGVEEGSSGDQPPYLDAKPPTP--GASFSQAESNVDPEPDSTQPLSKPAQKSEEANE 1771
             +   +   S+ D+      K  T    +  SQ +      P+     SK   K+    E
Sbjct: 250  PLEKSM---STLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGTPE 306

Query: 1772 PKAEKPDATADAEPDAN--------QKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKR 1823
               +  D+      D          Q+  +A E     +E  E     A ++  P+ ++ 
Sbjct: 307  ESEKTEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEP 366

Query: 1824 SKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNS 1883
            ++   + A  +    P      R        +  P G  +             R  + N 
Sbjct: 367  TENRERTANENTTLSPAEPTENRERTANENTAPFPAGPTEN------------REMTANE 414

Query: 1884 AADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAA 1943
               L   EP+    RT   N     A   +H  R+  +     P    +  ER     A 
Sbjct: 415  NTTLFPAEPTEHGERTANENTTPSPAEPTEHGERTANENTTPSPAEPTEHGERT--PFAN 472

Query: 1944 VPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNE 2003
              TT       +   R     EN    PAE  +  E  R+     T +  GP   +    
Sbjct: 473  DKTTSSSAESTEHGERTPLANENTTPSPAEPTENRE--RTANENTTPSPAGPTENRETTA 530

Query: 2004 PKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETA-PVEV 2062
             +     P   TE       +E++   K     A   +   R     +K    +A P E 
Sbjct: 531  NEKTTLSPVEPTEN------RETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEH 584

Query: 2063 VEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPE 2122
             E+ P   +N+         +R   +++A+ K   +   P     +             E
Sbjct: 585  GERTPLANENTTPSPAEPTENR---ERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAE 641

Query: 2123 KSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLA 2182
             +E+ Q+    + +  S   +P +  E+  ++    +P   +  +  E            
Sbjct: 642  PTENGQRTPFANEKTTSSSAEPTEHEERTPLANENTTPSPAEPTENRE------------ 689

Query: 2183 EASASAAYKADAPEGLAP-EDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPG 2241
                  A +   P    P E+R+  A++ +    A    +     + +  + PA P   G
Sbjct: 690  ----RTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENG 745

Query: 2242 ESQTDLQPPAGAQALQPSEEGMETDEAVSGI-LETEAATESSRPPVN---APDPSAGPTD 2297
            +          + + +P+E G  T  A     L     TE+     N    P P A PT+
Sbjct: 746  QRTPFANEKTTSSSAEPTEHGERTPLANENTTLSPAGPTENRERTANEKTTPFP-AEPTE 804

Query: 2298 TKEARGNSSET-SHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVA----PV 2352
             +E   N + T S + P   G +             + T   +R    N+K  +    P 
Sbjct: 805  NRERTANENTTPSPAQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTSSSAEPT 864

Query: 2353 E--SHVPESNQAQGESPA---------ANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSD 2401
            E     P +N+    SPA         ANE TT Q P  P E ++S     T P      
Sbjct: 865  EHAERTPLANENTTSSPAEPTENRERTANEKTT-QFPAEPTENRESTANEKTTP------ 917

Query: 2402 LSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTP 2461
                P+    ++E +  E T T +   P       P  VDE  QA FR  S  E      
Sbjct: 918  ---FPAEPTENREWTANENT-TLSPAEPTEHEEMTPLMVDENLQAPFRQGSCAER----- 968

Query: 2462 PSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPD 2521
               P     T+ S T ++             S  +++    T      A ST S      
Sbjct: 969  ---PKDICATVASTTGSE------------SSTASEIITSSTMSVSATASSTAS------ 1007

Query: 2522 TKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKP 2581
            + AS++  SS+ +         VS+T+  +   +TA++EPV+A+    E+          
Sbjct: 1008 STASEITMSSAAIP--------VSSTAYETIRFSTAVSEPVTASILALESTLAFTTVSNT 1059

Query: 2582 LEEKTAPPVTNNSEIQASEVLVAAD----KEKVAPVIAPKITSVISRMPVSIDLENSQKI 2637
                T   V   +    S+   A +    +  +A + A + T+V ++   S+    S   
Sbjct: 1060 TTSSTVTSVPTTASTSGSKNTTACEATMSETTIAAITASEDTTVSTQ--TSVIAAESVPH 1117

Query: 2638 TLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPV 2697
            T  K    T T  VSA         VP N     +  + +T  +  S      +      
Sbjct: 1118 TATKTPTDTTTASVSAT--------VPKNNTLSVITSTPSTAPNTASKTMTTASKTTTTS 1169

Query: 2698 NVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTV----------TAGAVT 2747
             + + P  V TT    T G+      T ++A +A++  AS  TV           A   T
Sbjct: 1170 TITSLPTTVFTTTSKITAGSEIPTASTTDSATTAISTKASGTTVESAPSTAPPTPAETTT 1229

Query: 2748 AASGGVTATTGTVTMAGAVIA--PST---KCKQRASANENSRFHPGSMPVIDDRPADAGS 2802
            A+    T+TTG+       ++  P+T      + ++ +E +R    +  V         +
Sbjct: 1230 ASVPTTTSTTGSENTGHHTVSSVPTTVFATASESSTGSETTRASTSATEVTTAMTTAMTT 1289

Query: 2803 GAGLRVNTSEGVVLLSYSGQKTEG--PQRISAKISQIPPASAMDIEFQQSVSKSQVKPDS 2860
            G+   V +++  V  + SG  T    P + +        ++ +      SV+KS    DS
Sbjct: 1290 GSETAVVSTKAPVTTTQSGFSTATVMPAKTTTASVSTTASTTLYQNTIDSVAKSVPTMDS 1349

Query: 2861 VTASQ 2865
              AS+
Sbjct: 1350 TIASK 1354



 Score =  100 bits (250), Expect = 2e-20
 Identities = 259/1307 (19%), Positives = 424/1307 (32%), Gaps = 172/1307 (13%)

Query: 1724 SGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADA 1783
            SG +PP L              E +      +T   SKP  K    ++    K       
Sbjct: 129  SGQRPPELP----------KSTEIHEQKRHCNTTRHSKPTDKPTGNSKTIDHKSSTDNHE 178

Query: 1784 EPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKP---- 1839
             P  +++  +     P       VDP  +    K +  K+  TP   + ++  +      
Sbjct: 179  APPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKINCRKSTTGKS 238

Query: 1840 -VTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSA------ADLEHPEP 1892
             VTRKS++  R        P  ++   L+    +   T T+  NS            PE 
Sbjct: 239  TVTRKSDKTGR--------PLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEK 290

Query: 1893 SLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLE----RELQEAAAVPT-- 1946
                S+T  +   +   +    ++R+ V       + T+   E     EL ++ A PT  
Sbjct: 291  ITAASKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEPTEH 350

Query: 1947 ---------TPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAA-GGGPQ 1996
                     TP    P + R R     EN    PAE   P E      ++ TA    GP 
Sbjct: 351  GGRTANENNTPSPAEPTENRERT--ANENTTLSPAE---PTENRERTANENTAPFPAGPT 405

Query: 1997 GKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPE 2056
              +     +     P   TE G +   + ++  P    E          + A  +  P  
Sbjct: 406  ENREMTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHG-------ERTANENTTPSP 458

Query: 2057 TAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGV 2116
              P E  E+ P     + S    S        +   L N +   SP     +  ER +  
Sbjct: 459  AEPTEHGERTPFANDKTTSSSAESTEH----GERTPLANENTTPSP-AEPTENRERTANE 513

Query: 2117 VAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVE 2176
                     +  +E   + +    PV+P +  E      + PSP     A+  E  Q   
Sbjct: 514  NTTPSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTPSP-----AEPTENGQRTP 568

Query: 2177 HIAKLAEASASAAYKADAPEGLAPEDRD-KPAHQASETELAAAIGSIINDISGEPENFPA 2235
               +   +S++   +      LA E+    PA      E  A         + +    PA
Sbjct: 569  FANEKTTSSSAEPTEHGERTPLANENTTPSPAEPTENRERTA---------NEKTTPSPA 619

Query: 2236 PPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPV--------- 2286
             P   G+              +P+E G  T  A       E  T SS  P          
Sbjct: 620  EPTENGDRTPLANEKTTPSLAEPTENGQRTPFA------NEKTTSSSAEPTEHEERTPLA 673

Query: 2287 --NAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEV-EVTLVRKDKGRQKTTRSRRKRN 2343
              N     A PT+ +E   N + T    P   G  E  E+T   K           R+R 
Sbjct: 674  NENTTPSPAEPTENRERTANENTT----PSPAGPTENREMTANEKTTLFPAEPTENRERT 729

Query: 2344 TNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLS 2403
             N+K      S   E  +    +P ANE TT    E       +E    TP  +  + LS
Sbjct: 730  ANEKTT----SSPAEPTENGQRTPFANEKTTSSSAEP------TEHGERTPLANENTTLS 779

Query: 2404 KIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPS 2463
                TEN        ERT  + + P     P +P       + R R  +   +     P+
Sbjct: 780  PAGPTEN-------RERTANEKTTPF----PAEPT------ENRERTANENTTPSPAQPT 822

Query: 2464 DPSIPIPTLPSVTAAKLSPPVASGG-IPHQSPPT-----KVTEWITRQEEPRAQSTPSPA 2517
            +     P     T   L+ P  +G   P  +  T     + TE   R       +T SPA
Sbjct: 823  ENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTSSSAEPTEHAERTPLANENTTSSPA 882

Query: 2518 LPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVD 2577
             P + +     T++    +   +P   +  S  +   T   AEP              + 
Sbjct: 883  EPTENRER---TANEKTTQFPAEPTE-NRESTANEKTTPFPAEPTENREWTANENTT-LS 937

Query: 2578 SKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKI 2637
              +P E +   P+  +  +QA      +  E+   + A   ++  S    + ++  S  +
Sbjct: 938  PAEPTEHEEMTPLMVDENLQAP-FRQGSCAERPKDICATVASTTGSESSTASEIITSSTM 996

Query: 2638 TLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPV 2697
            +++  A  T +   S +T  ++ + +PV++             + VS P      +   +
Sbjct: 997  SVSATASSTASSTASEIT--MSSAAIPVSS----TAYETIRFSTAVSEP------VTASI 1044

Query: 2698 NVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTV---TAGAVTAASGGVT 2754
              L   +   T     T  TV + P T + + S  N TA   T+   T  A+TA+     
Sbjct: 1045 LALESTLAFTTVSNTTTSSTVTSVPTTASTSGSK-NTTACEATMSETTIAAITASEDTTV 1103

Query: 2755 ATTGTVTMAGAVIAPSTKCKQRASANENSRFHP--GSMPVIDDRPADAGSGAGLRVNTSE 2812
            +T  +V  A +V   +TK     +    S   P   ++ VI   P+ A + A   + T+ 
Sbjct: 1104 STQTSVIAAESVPHTATKTPTDTTTASVSATVPKNNTLSVITSTPSTAPNTASKTMTTAS 1163

Query: 2813 GVVLLSYSGQKTEGPQRISAKI---SQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSK 2869
                 S            ++KI   S+IP AS  D     + +    K    T    PS 
Sbjct: 1164 KTTTTSTITSLPTTVFTTTSKITAGSEIPTASTTD----SATTAISTKASGTTVESAPST 1219

Query: 2870 GPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTV 2929
             P  PA     +  +T   T         +SSV         P  +  + S   T   T 
Sbjct: 1220 APPTPAETTTASVPTTTSTTGSENTGHHTVSSV---------PTTVFATASESSTGSETT 1270

Query: 2930 KVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPA 2976
            +  T        +       + + V + K           T  + PA
Sbjct: 1271 RASTSATEVTTAMTTAMTTGSETAVVSTKAPVTTTQSGFSTATVMPA 1317



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 242/1311 (18%), Positives = 427/1311 (32%), Gaps = 205/1311 (15%)

Query: 1966 NEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKE 2025
            +  + P E  K  E     R   T     P  K   N   +D        E  P      
Sbjct: 128  HSGQRPPELPKSTEIHEQKRHCNTTRHSKPTDKPTGNSKTIDHKSSTDNHEAPP------ 181

Query: 2026 SSMEPKAAEEEAGSEQKRD---RKDAGTDKNPPETAPVEVVEKK---PAPEKNSKSKRGR 2079
                     EE  S Q +D   R     D     T   E   KK   PAP+     ++  
Sbjct: 182  -------TSEENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKINCRKST 234

Query: 2080 SRNSRLAVDKSASLKNVDAAVSPRGAAAQAGER------ESGVVAVSPEKSESPQKEDGL 2133
            +  S +      + + ++ ++S     + +  +       SG      + +  P+K    
Sbjct: 235  TGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAA 294

Query: 2134 SSQLKSDPVDPDKEPEKEDVSASGPSPEA-TQLAKQME----LEQAVEHIAKLAEASASA 2188
            S         P++  + ED   +  S +  T+  K ++      +  + +A+  E     
Sbjct: 295  SKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEPTEHGGRT 354

Query: 2189 AYKADAPEGLAP-EDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGE----S 2243
            A + + P    P E+R++ A++ +    A    +     +     FPA P    E     
Sbjct: 355  ANENNTPSPAEPTENRERTANENTTLSPAEPTENRERTANENTAPFPAGPTENREMTANE 414

Query: 2244 QTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPS-AGPTDTKEAR 2302
             T L P       +P+E G  T    +     E      R       PS A PT+  E  
Sbjct: 415  NTTLFPA------EPTEHGERTANENTTPSPAEPTEHGERTANENTTPSPAEPTEHGERT 468

Query: 2303 --GNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRK---RNTNKKVVAPVESHVP 2357
               N   TS S    +  +   +          + T +R +    NT      P E+   
Sbjct: 469  PFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANENTTPSPAGPTENRET 528

Query: 2358 ESNQAQGESPAA---NEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQE 2414
             +N+    SP     N  TT      P   + +E    TP  +  +  S    TE+  + 
Sbjct: 529  TANEKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERT 588

Query: 2415 ISVEERTPTKASVPPD----------LPPPPQPAPV-DEEPQARFRVHSII----ESDPV 2459
                E T    + P +           P P +P    D  P A  +    +    E+   
Sbjct: 589  PLANENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQR 648

Query: 2460 TPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALP 2519
            TP ++      +       + +P       P  + PT+      R+      +TPSPA P
Sbjct: 649  TPFANEKTTSSSAEPTEHEERTPLANENTTPSPAEPTE-----NRERTANENTTPSPAGP 703

Query: 2520 PDTKASDVDTSSSTLRKILMDPKYVSATSVTSTS-----------------VTTAIAEPV 2562
             + +    +  ++       + +  +A   T++S                  T++ AEP 
Sbjct: 704  TENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTPFANEKTTSSSAEPT 763

Query: 2563 S---AAPCLHE----APPPPVDSK-KPLEEKTAP---PVTNNSEIQASEVLVAADKEKVA 2611
                  P  +E    +P  P +++ +   EKT P     T N E  A+E    +  +   
Sbjct: 764  EHGERTPLANENTTLSPAGPTENRERTANEKTTPFPAEPTENRERTANENTTPSPAQPTE 823

Query: 2612 PVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGP 2671
                  + +  +   ++   EN ++   A    +T +             L   N    P
Sbjct: 824  NGDRTPLANEKTTPSLAEPTENGKRTPFANE--KTTSSSAEPTEHAERTPLANENTTSSP 881

Query: 2672 VKGSV----TTLKSLVSTPAGPVNVLKGPVNVLTGPV--------------NVLTTPVNA 2713
             + +     T  +     PA P    +   N  T P               N   +P   
Sbjct: 882  AEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANENTTLSPAEP 941

Query: 2714 T------------------------------VGTVNAAPGTVNAAASAVNATASAVTVTA 2743
            T                                TV +  G+ ++ AS +  T+S ++V+A
Sbjct: 942  TEHEEMTPLMVDENLQAPFRQGSCAERPKDICATVASTTGSESSTASEI-ITSSTMSVSA 1000

Query: 2744 GAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPG-SMPVIDDRPADAGS 2802
             A + AS    +T   +TM+ A I  S+      +A E  RF    S PV          
Sbjct: 1001 TASSTAS----STASEITMSSAAIPVSS------TAYETIRFSTAVSEPV---------- 1040

Query: 2803 GAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSK---SQVKPD 2859
                   T+  + L S     T      S+ ++ +P  ++       +  +   S+    
Sbjct: 1041 -------TASILALESTLAFTTVSNTTTSSTVTSVPTTASTSGSKNTTACEATMSETTIA 1093

Query: 2860 SVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSV 2919
            ++TAS+  +   Q     A    H+       T  AS     V A  P   K   + +  
Sbjct: 1094 AITASEDTTVSTQTSVIAAESVPHTATKTPTDTTTAS-----VSATVP---KNNTLSVIT 1145

Query: 2920 STPVTQGGTV-KVLTQGINTPPVLVHNQL----VLTPSIVTTNKKLADPVTLKIETKVLQ 2974
            STP T   T  K +T    T        L      T S +T   ++    T    T  + 
Sbjct: 1146 STPSTAPNTASKTMTTASKTTTTSTITSLPTTVFTTTSKITAGSEIPTASTTDSATTAIS 1205

Query: 2975 PANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSH--LAAAKLDAHSPRPSGPG 3032
                G+T+      A P+   T    VP+  S        H  +++      +       
Sbjct: 1206 TKASGTTVESAPSTAPPTPAETTTASVPTTTSTTGSENTGHHTVSSVPTTVFATASESST 1265

Query: 3033 PSSFPRASHPSSTASTALST-----NATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQT 3087
             S   RAS  ++  +TA++T     + T +++   PV    S      + +MP  + T +
Sbjct: 1266 GSETTRASTSATEVTTAMTTAMTTGSETAVVSTKAPVTTTQSGF--STATVMPAKTTTAS 1323

Query: 3088 VSL---SHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQ 3135
            VS    + L Q  +     ++P++  +I  ++    +    P  + ++AP+
Sbjct: 1324 VSTTASTTLYQNTIDSVAKSVPTMDSTIASKSTTLSKIVSVPTAVFIKAPE 1374



 Score = 36.6 bits (83), Expect = 0.47
 Identities = 35/162 (21%), Positives = 59/162 (36%), Gaps = 9/162 (5%)

Query: 3338 KTAAQGPPPEGEPLQPPQPVQSTQPAQPAP-PCPPSQLGQPGQPPSSKMPQVSQEAKGTQ 3396
            +TA +   P   P +P +  + T      P P  P++ G+  + P +     S  A+ T+
Sbjct: 429  RTANENTTPS--PAEPTEHGERTANENTTPSPAEPTEHGE--RTPFANDKTTSSSAESTE 484

Query: 3397 TGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQP 3456
             G    R P    N  P P    +  +      + PSP   +   +   +  T  +P +P
Sbjct: 485  HG---ERTPLANENTTPSPAEPTENRERTANENTTPSPAGPTENRETTANEKTTLSPVEP 541

Query: 3457 L-FVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRPVD 3497
                 TT+   T P    P    Q  P  +     +S  P +
Sbjct: 542  TENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTE 583


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score =  107 bits (266), Expect = 3e-22
 Identities = 220/1054 (20%), Positives = 354/1054 (33%), Gaps = 115/1054 (10%)

Query: 1624 PENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEA 1683
            P +  S  K PP  G       T + +P    K    K +E+  +TEE +V     S  +
Sbjct: 69   PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 128

Query: 1684 KPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFS 1743
              +S  +      + ++     +  ++E       V++            KPP       
Sbjct: 129  SSSSSSS----STIRKIKSSKNSAANRE-LQKKLKVKDNKKNRTKKKPTPKPPV----VD 179

Query: 1744 QAESNVD-PEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPAS 1802
            +A S +D  +   T P +   Q ++ +  PK         A+P         P    P +
Sbjct: 180  EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPK------ITTAKP-------INPRPSLPPN 226

Query: 1803 EDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEA 1862
             D   +  +    +   ++K + T  +  +    EK  + K  +   +   +  +P  + 
Sbjct: 227  SDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV 286

Query: 1863 QKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKE 1922
              L +   +AE  T+  +  +  +     P  P S T +    +          +S    
Sbjct: 287  --LAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI--------KSAPTT 336

Query: 1923 PVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWR 1982
            P E    T K          + PTTP+   P  T+  A    +  A    +   P     
Sbjct: 337  PKEPAPTTTK----------SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 386

Query: 1983 SPRSQKTAAGGGPQGKKGKNEPKVDA----TRPEATTEVGPQIGVKESSMEPKAAEEEAG 2038
            +P + K  A   P+ K     PK  A      P  TT   P    KE +  P   +E A 
Sbjct: 387  APTTPKEPAPTTPK-KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPA--PTTPKEPAP 443

Query: 2039 SEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDA 2098
            +  K+      T K P  T P     K+PAP    +      +       KSA     + 
Sbjct: 444  TAPKKPAPT--TPKEPAPTTP-----KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEP 496

Query: 2099 AVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGP 2158
            A +   +A    +  S      P  + +  KE   ++  K  P  P KEP     +   P
Sbjct: 497  APTTTKSAPTTPKEPSPTTTKEP--APTTPKEPAPTTPKKPAPTTP-KEP--APTTPKEP 551

Query: 2159 SPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAA 2218
            +P  T+       ++      K    +         PE LAP   +KPA    E ELA  
Sbjct: 552  APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE-ELA-- 608

Query: 2219 IGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAA 2278
                       P     P P   E      P A A    P E    T        +  A 
Sbjct: 609  -----------PTTPEEPTPTTPEEPAPTTPKAAAPN-TPKEPAPTTP-------KEPAP 649

Query: 2279 TESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRS 2338
            T    P    P  +A  T    A     E + + P+    KE+  T  ++      +T  
Sbjct: 650  TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKE----PTSTTC 705

Query: 2339 RRKRNTNKKVVAPVESHVPESNQAQGESPAANEG---TTVQHPEAPQEEKQSEK---PHS 2392
             +   T  K  AP     P     +  +P   +G   TT++ P     +K + K   P +
Sbjct: 706  DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 765

Query: 2393 TP-PQSCTSDLSKIPSTENSSQEISVEERTPTKASVP-PDLPPPPQPAPVDEEPQARFRV 2450
            T  P S TSD    P+T   +   + +E  PT    P P  P  P P   +       + 
Sbjct: 766  TKGPTSTTSD-KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE 824

Query: 2451 HSIIESDPVTPPSDPSIPI-PTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPR 2509
             + I   P    S P +   PT  ++  +   P V +   P  + P   T    +  E  
Sbjct: 825  PTTIHKSP--DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERD 882

Query: 2510 AQSTP--SPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTS-------VTTAIAE 2560
             ++TP  + A P  TK +   T  +T  KI      V++T+   T+        TT +A 
Sbjct: 883  LRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAP 942

Query: 2561 PVSAAP---CLHEAPPPPVDSKKPLEEKTAPPVTN---NSEIQASEVLVAADKEKVAPVI 2614
             V+         E    P ++ KP +  T    T        +A +   +  K K  P +
Sbjct: 943  KVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRV 1002

Query: 2615 APKITSVISRMPVSIDLENSQKITLAKPAPQTLT 2648
                T+   R   S   E +    +A+   QT T
Sbjct: 1003 RKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTT 1036



 Score =  100 bits (250), Expect = 2e-20
 Identities = 236/1140 (20%), Positives = 367/1140 (32%), Gaps = 160/1140 (14%)

Query: 1946 TTPRRGRPP---KTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKN 2002
            TT R  +PP   KT++  + EE  E    +E  +      S  S  T      + K  KN
Sbjct: 91   TTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIR----KIKSSKN 146

Query: 2003 EPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGS-----EQKRDRKDAGTDK-NPPE 2056
                   + +   +   +   K+         +EAGS     + K    D  T + N   
Sbjct: 147  SAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVS 206

Query: 2057 TAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERE--- 2113
            T+P     K   P  +       S+ + L V+K  +++  +   + +  +    E+    
Sbjct: 207  TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 266

Query: 2114 -----------------SGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSAS 2156
                             S V+A    K+E+  K   L++  +  P  P KEP     +  
Sbjct: 267  KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTP-KEPAS--TTPK 323

Query: 2157 GPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELA 2216
             P+P   + A     E A          SA    K  AP          P   A  T   
Sbjct: 324  EPTPTTIKSAPTTPKEPA-----PTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE 378

Query: 2217 AAIGSIINDISGEPENFPAPPPYPGESQTDLQP----PAGAQALQPSEEGMETDEAVSGI 2272
             A  +  +  +   E  P  P  P  + T  +P    P       P E    T E     
Sbjct: 379  PAPTTTKSAPTTPKEPAPTTPKKPAPT-TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 437

Query: 2273 LETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGR 2332
             +  A T   +P    P   A  T  + A   + E S + P+       +       +  
Sbjct: 438  PKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPA 497

Query: 2333 QKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEK-PH 2391
              TT+S     T  K  +P  +  P     +  +P   +      P+ P      E  P 
Sbjct: 498  PTTTKSAP---TTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT 554

Query: 2392 STPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPP--PPQPAPVDEEPQARFR 2449
            +T   + T+     P+T   +   + ++ TPT    P  L P  P +PAP   E  A   
Sbjct: 555  TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT---TPEKLAPTTPEKPAPTTPEELA--- 608

Query: 2450 VHSIIESDPVTP----PSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQ 2505
                    P TP    P+ P  P PT P   AA  +P   +   P +  PT   E     
Sbjct: 609  --------PTTPEEPTPTTPEEPAPTTPKA-AAPNTPKEPAPTTPKEPAPTTPKEPAPTT 659

Query: 2506 EEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVT------STSVTTAIA 2559
             +  A +TP    P   K     T      K L        TS T      +T   TA  
Sbjct: 660  PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT 719

Query: 2560 EPVSAAPCLHEAPPP---------------PVDSKKPLEEKTAPPVTNNSEIQASEVLVA 2604
             P   AP   + P P               P   KKP  ++ AP  T       S+    
Sbjct: 720  TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 779

Query: 2605 ADKEKVAPVIAPKITSVISRMPVSIDLENSQKIT--LAKPA----PQTLTGLVSALTGLV 2658
               ++ AP    +      + P     E     T  ++ P     P T+       T  +
Sbjct: 780  TTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPEL 839

Query: 2659 NVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVG-- 2716
            +    P      P +  V T K    TPA     +       T   ++ TTP   T    
Sbjct: 840  SAEPTPKALENSPKEPGVPTTK----TPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 895

Query: 2717 -TVNAAPGTVNAAASAVNATASAVT-----------VTAGAVTAASGGVTATTGTVTMAG 2764
             T   A  T     S + AT + VT           +T    T  +  VT T  T+T   
Sbjct: 896  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 955

Query: 2765 AVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQK- 2823
             +  P    K +  A  +    P        +P           +T +   +      K 
Sbjct: 956  IMNKPEETAKPKDRATNSKATTP--------KPQKPTKAPKKPTSTKKPKTMPRVRKPKT 1007

Query: 2824 TEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATH 2883
            T  P+++++ + ++ P S +     Q+ ++    P+S      P       AG A   T 
Sbjct: 1008 TPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK---SEDAGGAEGETP 1064

Query: 2884 STLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLV 2943
              L+                  RP +  PE       TP       +V  QGI      +
Sbjct: 1065 HMLL------------------RPHVFMPE------VTP-DMDYLPRVPNQGI------I 1093

Query: 2944 HNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPS 3003
             N ++   + +   K +    TL+  T V    +    L+P  PP+ P++  TEV  +PS
Sbjct: 1094 INPMLSDETNICNGKPVDGLTTLRNGTLVAFRGHYFWMLSPFSPPS-PARRITEVWGIPS 1152



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 191/944 (20%), Positives = 297/944 (31%), Gaps = 144/944 (15%)

Query: 1603 KPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKT 1662
            K   VE +E T  + +T     E K +  K   S+   S   +   S   A      + T
Sbjct: 239  KETTVETKETTTTNKQTSTDGKE-KTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETT 297

Query: 1663 VEAPLVTEEKTVEPATVSEEAKPA-SEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEE 1721
             + P +T  K   P T  E A     EP P  ++        P     K A   P     
Sbjct: 298  TKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAP 357

Query: 1722 GSSGD-------QPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKA 1774
             ++ +       +P     K P P  + S   +  +P P  T P  KPA  +     PK 
Sbjct: 358  TTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP--TTP-KKPAPTT-----PK- 408

Query: 1775 EKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVS 1834
             +P  T   EP      E AP ++ PA    +   P A K   P       TP + A   
Sbjct: 409  -EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT------TPKEPA--- 458

Query: 1835 IVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSL 1894
                P T K       K     +P+  A               T +K++    + P P+ 
Sbjct: 459  ----PTTPKEPAPTTTKEPSPTTPKEPAP--------------TTTKSAPTTTKEPAPTT 500

Query: 1895 PLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPP 1954
              S        S   T      + P     ++P  T  +           PTTP+   P 
Sbjct: 501  TKSAPTTPKEPSPTTT------KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT 554

Query: 1955 KTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEAT 2014
             T++ A        KEPA T  P E   +P + K      P+        K   T PE  
Sbjct: 555  TTKKPA----PTTPKEPAPT-TPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 607

Query: 2015 TEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSK 2074
                P+     +  EP     +A +          T K P  T P     K+PAP    +
Sbjct: 608  APTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP-----KEPAPTTPKE 662

Query: 2075 SKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLS 2134
            +                      A  +P+G A    +  +     +P+K    +     +
Sbjct: 663  T----------------------APTTPKGTAPTTLKEPA---PTTPKKPAPKELAPTTT 697

Query: 2135 SQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADA 2194
             +  S   D       +  + + P   A    K+              +  A    K  A
Sbjct: 698  KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 757

Query: 2195 PEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQ 2254
            P+ LAP     P    S+                EP   P  P  P  +  +  PP    
Sbjct: 758  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA--PTTPKKPAPTTPETPPPT--- 812

Query: 2255 ALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPE 2314
                      T E  +     E  T    P  + P+ SA PT  K    +  E      +
Sbjct: 813  ----------TSEVSTPTTTKEPTTIHKSPDESTPELSAEPT-PKALENSPKEPGVPTTK 861

Query: 2315 AKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTT 2374
               + + E+T   KDK  ++  R+  +  T     AP         +   E+    E TT
Sbjct: 862  TPAATKPEMTTTAKDKTTERDLRTTPETTT----AAP---------KMTKETATTTEKTT 908

Query: 2375 VQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPP 2434
                 A   +  S     T P   T+       T   + +++  ++T T   +   +  P
Sbjct: 909  ESKITATTTQVTSTTTQDTTPFKITT-----LKTTTLAPKVTTTKKTITTTEI---MNKP 960

Query: 2435 PQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPI-----PTLPSVTAAKLSPP--VASG 2487
             + A    +P+ R          P  P   P  P       T+P V   K +P     + 
Sbjct: 961  EETA----KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTS 1016

Query: 2488 GIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSS 2531
             +P  +P +++        E   Q+T  P   P++K  +V+  S
Sbjct: 1017 TMPELNPTSRIA-------EAMLQTTTRPNQTPNSKLVEVNPKS 1053



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 166/715 (23%), Positives = 244/715 (34%), Gaps = 96/715 (13%)

Query: 2820 SGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYAN 2879
            S ++T+  ++ SAK   + P S +  +       +   P   T  +P    P+ PA    
Sbjct: 265  SAKETQSIEKTSAK--DLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTP 322

Query: 2880 VATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTP 2939
                 T + +A T    P  ++ K+   + ++P P       P T        T+    P
Sbjct: 323  KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTK---EP 379

Query: 2940 PVLVHNQLVLTPS--IVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHP-PALPSK-LP 2995
                      TP     TT KK A P T K      +PA      TP  P P  P +  P
Sbjct: 380  APTTTKSAPTTPKEPAPTTPKKPA-PTTPK------EPA----PTTPKEPTPTTPKEPAP 428

Query: 2996 TEVNHVPSGPSIPADRTVSHLAAAKLDAHSP-RPSGPGPSSFPRASHPSSTASTALSTNA 3054
            T     P+ P  PA       A       +P  P  P P++    S P++    A +T  
Sbjct: 429  TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS-PTTPKEPAPTTTK 487

Query: 3055 TVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRP 3114
            +       P P    S            + T     S  +  E    TP  P+ T   +P
Sbjct: 488  SAPTTTKEPAPTTTKS------------APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKP 535

Query: 3115 EALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQ 3174
                +P  P +P     + P   +T +PAP      A   P E            TAP  
Sbjct: 536  ----APTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKE------------TAPTT 579

Query: 3175 SEVLVMQSEYRLHPY-------TVPRDVRIMVHPHVTAVSEQ------PRAADGVVKVPP 3221
             + L   +  +L P        T P ++        T  + +      P+AA       P
Sbjct: 580  PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 639

Query: 3222 ASKAPQQPG----KEAAKTPDAKAAPTPTPAPVPVPVPLPAPA----PAPHGEARILTVT 3273
            A   P++P     KE A T   + APT      P  +  PAP     PAP   A   T  
Sbjct: 640  APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKE 699

Query: 3274 PSNQL--QGLPLTP--PVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAAS 3329
            P++    +  P TP      T       +  E       G   T       T  + PA  
Sbjct: 700  PTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK 759

Query: 3330 SVGLPSRTK----TAAQGP----PPEGEPLQPPQPVQST--QPAQPAPPCPPSQLGQPGQ 3379
             +  P+ TK    T +  P    P E  P  P +P  +T  +PA   P  PP    +   
Sbjct: 760  ELA-PTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 818

Query: 3380 PPSSKMPQVSQEAKGTQTGVEQPRLPAGPA-----NRPPEPHTQVQRAQAETGPTSFPSP 3434
            P ++K P    ++    T    P L A P      N P EP     +  A T P    + 
Sbjct: 819  PTTTKEPTTIHKSPDEST----PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA 874

Query: 3435 VSVSMKPDLPVSLPTQT-APKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSP 3488
               + + DL  +  T T APK      TT+  +T   +    T+      QD++P
Sbjct: 875  KDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 929



 Score = 76.6 bits (187), Expect = 4e-13
 Identities = 113/519 (21%), Positives = 167/519 (32%), Gaps = 67/519 (12%)

Query: 2991 PSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTAL 3050
            P    T+ N V + P I   + ++           PRPS       P  S  S   S  +
Sbjct: 195  PDTSTTQHNKVSTSPKITTAKPIN-----------PRPS------LPPNSDTSKETSLTV 237

Query: 3051 STNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITY 3110
            +   TV         +  S+   E++         +  S   L+     +  PT P    
Sbjct: 238  NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT-PKAET 296

Query: 3111 SIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARAT 3170
            + +  AL +P+   +P     + P   +  +P P  + +  +   P+E      P    +
Sbjct: 297  TTKGPALTTPK---EPTPTTPKEPASTTPKEPTPTTIKSAPTT--PKEPA----PTTTKS 347

Query: 3171 APVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPG 3230
            AP   +     +     P T P++      P  T   E            P   AP  P 
Sbjct: 348  APTTPKEPAPTTTKEPAP-TTPKE------PAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 400

Query: 3231 KEAAKTPDAKAAPTP---TPAPVPVPVPL---PAPA----PAPHGEARILTVTPSNQLQG 3280
            K A  TP   A  TP   TP     P P    PAP     PAP    +    TP      
Sbjct: 401  KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 460

Query: 3281 LPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTA 3340
             P  P    T                +     T   PA  T    P  +    P+ TK+A
Sbjct: 461  TPKEPAPTTT----------------KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 504

Query: 3341 AQGPP-PEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGV 3399
               P  P     + P P    +PA   P  P     +   P + K P  +   K   T  
Sbjct: 505  PTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTP 564

Query: 3400 EQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSL--PTQTAPKQPL 3457
            ++P         P  P         +  PT+   P   + +   P +   PT T P++P 
Sbjct: 565  KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP- 623

Query: 3458 FVPTTSGPSTP--PGLVLPHTEFQPAPKQDSSPHLTSQR 3494
              PTT   + P  P    P T  +PAP     P  T+ +
Sbjct: 624  -APTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPK 661



 Score = 72.4 bits (176), Expect = 8e-12
 Identities = 123/587 (20%), Positives = 180/587 (30%), Gaps = 72/587 (12%)

Query: 1600 KDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTG 1659
            K+  P   +K   T      P +  E   +  K P    P      T +SAP+  ++   
Sbjct: 439  KEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP 498

Query: 1660 DKTVEAPLVTEE----KTVEPA-TVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAM 1714
              T  AP   +E     T EPA T  +E  P +   PAP    E     P  +P      
Sbjct: 499  TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP-KEPAPTTTK 557

Query: 1715 MPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKA 1774
             PA           P  +  P TP     +  +   PE  +     KPA  + E   P  
Sbjct: 558  KPAPTTPKEPAPTTP-KETAPTTP-----KKLTPTTPEKLAPTTPEKPAPTTPEELAPTT 611

Query: 1775 -EKPDATADAEPDANQKAEAAPES-QPPASEDLEVDPPVAAKDKKPNKSKRS--KTPVQA 1830
             E+P  T   EP       AAP + + PA    +   P   K+  P   K +   TP   
Sbjct: 612  PEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 671

Query: 1831 AAVSIVE--------------KPVTRKSERIDREKLKRSNSPRGEA---QKLLELKMEAE 1873
            A  ++ E               P T K             +P+G A    K        E
Sbjct: 672  APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 731

Query: 1874 KITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKR 1933
                T    +   L+ P P+ P     +         +     + P     ++P  T  +
Sbjct: 732  PAPTTPKGTAPTTLKEPAPTTPKKPAPKE--------LAPTTTKGPTSTTSDKPAPTTPK 783

Query: 1934 LERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGG 1993
                       PTTP+  +P  T         +E   P  T +P    +SP         
Sbjct: 784  ETAPTTPKEPAPTTPK--KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 841

Query: 1994 GPQGKKGKNEPK---VDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGT 2050
             P  K  +N PK   V  T+  A T+                 E    ++ K   +D  T
Sbjct: 842  EPTPKALENSPKEPGVPTTKTPAATK----------------PEMTTTAKDKTTERDLRT 885

Query: 2051 DKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVD-------KSASLKNVDAAVSPR 2103
                   AP    E     EK ++SK   +     +         K  +LK    A    
Sbjct: 886  TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 945

Query: 2104 GAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEK 2150
                     E   +   PE++  P+     S      P  P K P+K
Sbjct: 946  TTKKTITTTE---IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKK 989



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 231/1166 (19%), Positives = 360/1166 (30%), Gaps = 162/1166 (13%)

Query: 2392 STPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDE--EPQARFR 2449
            ++PP S      K P    +SQ I    ++ TK S     P PP      +  E +    
Sbjct: 70   TSPPSS-----KKAPPPSGASQTI----KSTTKRS-----PKPPNKKKTKKVIESEEITE 115

Query: 2450 VHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPR 2509
             HS+ E+   +  S  S    T+  + ++K S         ++    K+     ++   +
Sbjct: 116  EHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAA-------NRELQKKLKVKDNKKNRTK 168

Query: 2510 AQSTPSPALPP---------DTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAE 2560
             + TP P +           D K +  DTS++   K+   PK           +TTA  +
Sbjct: 169  KKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPK-----------ITTA--K 215

Query: 2561 PVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAAD------KEKVAPVI 2614
            P++  P L    PP  D+ K    +T+  V   + ++  E            KEK     
Sbjct: 216  PINPRPSL----PPNSDTSK----ETSLTVNKETTVETKETTTTNKQTSTDGKEKTT--- 264

Query: 2615 APKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKG 2674
            + K T  I +     DL  + K+ LAKP P+  T                  AL  P + 
Sbjct: 265  SAKETQSIEKTSAK-DLAPTSKV-LAKPTPKAETTTKGP-------------ALTTPKEP 309

Query: 2675 SVTTLKSLVST-PAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVN 2733
            + TT K   ST P  P      P  + + P    TTP      T  +AP T    A    
Sbjct: 310  TPTTPKEPASTTPKEPT-----PTTIKSAP----TTPKEPAPTTTKSAPTTPKEPAPTTT 360

Query: 2734 ATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVI 2793
               +  T    A T        TT +        AP+T  K                P  
Sbjct: 361  KEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPA--------------PTT 406

Query: 2794 DDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSK 2853
               PA             E           T      +A     P         ++    
Sbjct: 407  PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTP------KEPAPT 460

Query: 2854 SQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPE 2913
            +  +P   T  +P    P+ PA         T   +A T    P  ++ K+   + ++P 
Sbjct: 461  TPKEPAPTTTKEPSPTTPKEPA--------PTTTKSAPTTTKEPAPTTTKSAPTTPKEPS 512

Query: 2914 PIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPS--IVTTNKKLADPVTLKIETK 2971
            P       P T         +     P         TP     TT KK A P T K E  
Sbjct: 513  PTTTKEPAPTTPKEPAPTTPK--KPAPTTPKEPAPTTPKEPAPTTTKKPA-PTTPK-EPA 568

Query: 2972 VLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPR-PSG 3030
               P     T      P  P KL       P+ P  PA  T   LA    +  +P  P  
Sbjct: 569  PTTPKETAPTTPKKLTPTTPEKL------APTTPEKPAPTTPEELAPTTPEEPTPTTPEE 622

Query: 3031 PGPSSFPRASHPSSTASTALST-NATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVS 3089
            P P++ P+A+ P++    A +T           P P       P       P ++ +   
Sbjct: 623  PAPTT-PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP 681

Query: 3090 LSHLSQG--EVRMNTPTLPSITYSIRPEALHSPR--APLQPQQIEVRAPQRASTPQPAPA 3145
             +       E+   T   P+ T   +P A  +P+  AP  P++     P+  +   P   
Sbjct: 682  TTPKKPAPKELAPTTTKEPTSTTCDKP-APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGT 740

Query: 3146 GVPALASQHP--PEEEVHYHLPVARATAPVQ--SEVLVMQSEYRLHPYTVPRDVRIMVHP 3201
                L    P  P++     L       P    S+     +     P T           
Sbjct: 741  APTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKK 800

Query: 3202 HVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAK-TPDAKAAPTP-----TPAPVPVPVP 3255
                  E P      V  P  +K P    K   + TP+  A PTP     +P    VP  
Sbjct: 801  PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTT 860

Query: 3256 LPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYH 3315
                A  P         T    L+    T P   T   ++   +    ++     I    
Sbjct: 861  KTPAATKPEMTTTAKDKTTERDLR----TTPETTTAAPKMTKETATTTEKTTESKITATT 916

Query: 3316 PPAQLTHTQFPAASSVGLPSRTKTAAQGPPPE---------GEPLQPPQPVQSTQPAQPA 3366
                 T TQ      +     T  A +    +          +P +  +P      ++  
Sbjct: 917  TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 976

Query: 3367 PPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAET 3426
             P P      P +P S+K P+     +  +T     ++ +      P         Q  T
Sbjct: 977  TPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTT 1036

Query: 3427 GPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGL-VLPHTEFQPA---P 3482
             P   P+   V + P    +   +      L  P    P   P +  LP    Q     P
Sbjct: 1037 RPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINP 1096

Query: 3483 KQDSSPHLTSQRPVDMVQLLKKYPIV 3508
                  ++ + +PVD +  L+   +V
Sbjct: 1097 MLSDETNICNGKPVDGLTTLRNGTLV 1122



 Score = 60.5 bits (145), Expect = 3e-08
 Identities = 190/979 (19%), Positives = 307/979 (31%), Gaps = 99/979 (10%)

Query: 2360 NQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEE 2419
            N+ + +    +E  T +H  +  +E  S    S+   S +S + KI S++NS+    +++
Sbjct: 100  NKKKTKKVIESEEITEEHSVSENQESSS----SSSSSSSSSTIRKIKSSKNSAANRELQK 155

Query: 2420 RTPTKASVP--PDLPPPPQPAPVDEE-------------PQARFRVHSIIESDPVTPPSD 2464
            +   K +        P P+P  VDE              P      H+ + + P    + 
Sbjct: 156  KLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAK 215

Query: 2465 PSIPIPTLP--SVTAAKLSPPVASGGIPHQSPPT---KVTEWITRQEEPRAQST------ 2513
            P  P P+LP  S T+ + S  V           T   K T    +++   A+ T      
Sbjct: 216  PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 275

Query: 2514 --------------PSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIA 2559
                          P+P     TK   + T          +P   +    T T++ +A  
Sbjct: 276  SAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 335

Query: 2560 EPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKIT 2619
             P   AP   ++ P       P   K   P T       +    A    K AP    +  
Sbjct: 336  TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 395

Query: 2620 SVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVN-ALKGPVKGSVTT 2678
                + P     +     T  +P P   T    A T        P   A   P K + TT
Sbjct: 396  PTTPKKPAPTTPKEPAPTTPKEPTP--TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTT 453

Query: 2679 LKS-LVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATAS 2737
             K    +TP  P        +  T      TT  +A   T   AP T  +A +     + 
Sbjct: 454  PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 513

Query: 2738 AVTVTAGAVTAASGGVTATTGTVTMAGAVIAPST-KCKQRASANENSRFHPGSMPVIDDR 2796
              T      T      T             AP+T K     +  + +   P        +
Sbjct: 514  TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK 573

Query: 2797 PADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIP----PASAMDIEFQQSVS 2852
                 +   L   T E +   +        P+ ++    + P    P        + +  
Sbjct: 574  ETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 633

Query: 2853 KSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSL-EK 2911
             +  +P   T  +P    P+ PA        +T   TA T       +++K   P+  +K
Sbjct: 634  NTPKEPAPTTPKEPAPTTPKEPA-------PTTPKETAPTTPKGTAPTTLKEPAPTTPKK 686

Query: 2912 PEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETK 2971
            P P  L+ +T  T+  T     +   T P               T  K   P T K E  
Sbjct: 687  PAPKELAPTT--TKEPTSTTCDKPAPTTP----------KGTAPTTPKEPAPTTPK-EPA 733

Query: 2972 VLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGP 3031
               P     T      P  P K P      P+    P   T    A       +P+ + P
Sbjct: 734  PTTPKGTAPTTLKEPAPTTPKK-PAPKELAPTTTKGPTSTTSDKPAPT-----TPKETAP 787

Query: 3032 GPSSFPRASHPSSTASTALSTNATVMLAAGIP-VPQFISSIHPEQSVIMPPHSITQTVSL 3090
                 P  + P   A T   T          P   +  ++IH       P  S   T   
Sbjct: 788  TTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKA 847

Query: 3091 SHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPAL 3150
               S  E  + T   P+ T   +PE   +  A  +  + ++R     +T  P      A 
Sbjct: 848  LENSPKEPGVPTTKTPAAT---KPEM--TTTAKDKTTERDLRTTPETTTAAPKMTKETAT 902

Query: 3151 ASQHPPEEEVHYHLPVARATAPVQS---EVLVMQSEYRLHPYTVPR----DVRIMVHPHV 3203
             ++   E ++        +T    +   ++  +++       T  +       IM  P  
Sbjct: 903  TTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEE 962

Query: 3204 TAVSEQPRAADGVVKVP---PASKAPQQP-GKEAAKTPDAKAAPTPTPAPVPVPVPLPAP 3259
            TA   + RA +     P     +KAP++P   +  KT      P  TP P  +   +P  
Sbjct: 963  TA-KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPEL 1021

Query: 3260 APAPH-GEARILTVTPSNQ 3277
             P     EA + T T  NQ
Sbjct: 1022 NPTSRIAEAMLQTTTRPNQ 1040



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 6/91 (6%)

Query: 250 SRNQSPQRLASQASRPT--RSPSGSGSRSRSS--SSDSISSSSSTSS--DSSDSSSSSSD 303
           S+   P   ASQ  + T  RSP     +       S+ I+   S S   +SS SSSSSS 
Sbjct: 75  SKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSS 134

Query: 304 DSPARSVQSAAVPAPTSQLLSSLEKDEPRKS 334
            S  R ++S+   A   +L   L+  + +K+
Sbjct: 135 SSTIRKIKSSKNSAANRELQKKLKVKDNKKN 165


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score =  107 bits (266), Expect = 3e-22
 Identities = 220/1054 (20%), Positives = 354/1054 (33%), Gaps = 115/1054 (10%)

Query: 1624 PENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEA 1683
            P +  S  K PP  G       T + +P    K    K +E+  +TEE +V     S  +
Sbjct: 110  PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 169

Query: 1684 KPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFS 1743
              +S  +      + ++     +  ++E       V++            KPP       
Sbjct: 170  SSSSSSS----STIRKIKSSKNSAANRE-LQKKLKVKDNKKNRTKKKPTPKPPV----VD 220

Query: 1744 QAESNVD-PEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPAS 1802
            +A S +D  +   T P +   Q ++ +  PK         A+P         P    P +
Sbjct: 221  EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPK------ITTAKP-------INPRPSLPPN 267

Query: 1803 EDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEA 1862
             D   +  +    +   ++K + T  +  +    EK  + K  +   +   +  +P  + 
Sbjct: 268  SDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV 327

Query: 1863 QKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKE 1922
              L +   +AE  T+  +  +  +     P  P S T +    +          +S    
Sbjct: 328  --LAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI--------KSAPTT 377

Query: 1923 PVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWR 1982
            P E    T K          + PTTP+   P  T+  A    +  A    +   P     
Sbjct: 378  PKEPAPTTTK----------SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 427

Query: 1983 SPRSQKTAAGGGPQGKKGKNEPKVDA----TRPEATTEVGPQIGVKESSMEPKAAEEEAG 2038
            +P + K  A   P+ K     PK  A      P  TT   P    KE +  P   +E A 
Sbjct: 428  APTTPKEPAPTTPK-KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPA--PTTPKEPAP 484

Query: 2039 SEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDA 2098
            +  K+      T K P  T P     K+PAP    +      +       KSA     + 
Sbjct: 485  TAPKKPAPT--TPKEPAPTTP-----KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEP 537

Query: 2099 AVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGP 2158
            A +   +A    +  S      P  + +  KE   ++  K  P  P KEP     +   P
Sbjct: 538  APTTTKSAPTTPKEPSPTTTKEP--APTTPKEPAPTTPKKPAPTTP-KEP--APTTPKEP 592

Query: 2159 SPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAA 2218
            +P  T+       ++      K    +         PE LAP   +KPA    E ELA  
Sbjct: 593  APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE-ELA-- 649

Query: 2219 IGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAA 2278
                       P     P P   E      P A A    P E    T        +  A 
Sbjct: 650  -----------PTTPEEPTPTTPEEPAPTTPKAAAPN-TPKEPAPTTP-------KEPAP 690

Query: 2279 TESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRS 2338
            T    P    P  +A  T    A     E + + P+    KE+  T  ++      +T  
Sbjct: 691  TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKE----PTSTTC 746

Query: 2339 RRKRNTNKKVVAPVESHVPESNQAQGESPAANEG---TTVQHPEAPQEEKQSEK---PHS 2392
             +   T  K  AP     P     +  +P   +G   TT++ P     +K + K   P +
Sbjct: 747  DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 806

Query: 2393 TP-PQSCTSDLSKIPSTENSSQEISVEERTPTKASVP-PDLPPPPQPAPVDEEPQARFRV 2450
            T  P S TSD    P+T   +   + +E  PT    P P  P  P P   +       + 
Sbjct: 807  TKGPTSTTSD-KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKE 865

Query: 2451 HSIIESDPVTPPSDPSIPI-PTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPR 2509
             + I   P    S P +   PT  ++  +   P V +   P  + P   T    +  E  
Sbjct: 866  PTTIHKSP--DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERD 923

Query: 2510 AQSTP--SPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTS-------VTTAIAE 2560
             ++TP  + A P  TK +   T  +T  KI      V++T+   T+        TT +A 
Sbjct: 924  LRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAP 983

Query: 2561 PVSAAP---CLHEAPPPPVDSKKPLEEKTAPPVTN---NSEIQASEVLVAADKEKVAPVI 2614
             V+         E    P ++ KP +  T    T        +A +   +  K K  P +
Sbjct: 984  KVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRV 1043

Query: 2615 APKITSVISRMPVSIDLENSQKITLAKPAPQTLT 2648
                T+   R   S   E +    +A+   QT T
Sbjct: 1044 RKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTT 1077



 Score =  100 bits (250), Expect = 2e-20
 Identities = 236/1140 (20%), Positives = 367/1140 (32%), Gaps = 160/1140 (14%)

Query: 1946 TTPRRGRPP---KTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKN 2002
            TT R  +PP   KT++  + EE  E    +E  +      S  S  T      + K  KN
Sbjct: 132  TTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIR----KIKSSKN 187

Query: 2003 EPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGS-----EQKRDRKDAGTDK-NPPE 2056
                   + +   +   +   K+         +EAGS     + K    D  T + N   
Sbjct: 188  SAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVS 247

Query: 2057 TAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERE--- 2113
            T+P     K   P  +       S+ + L V+K  +++  +   + +  +    E+    
Sbjct: 248  TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 307

Query: 2114 -----------------SGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSAS 2156
                             S V+A    K+E+  K   L++  +  P  P KEP     +  
Sbjct: 308  KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTP-KEPAS--TTPK 364

Query: 2157 GPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELA 2216
             P+P   + A     E A          SA    K  AP          P   A  T   
Sbjct: 365  EPTPTTIKSAPTTPKEPA-----PTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE 419

Query: 2217 AAIGSIINDISGEPENFPAPPPYPGESQTDLQP----PAGAQALQPSEEGMETDEAVSGI 2272
             A  +  +  +   E  P  P  P  + T  +P    P       P E    T E     
Sbjct: 420  PAPTTTKSAPTTPKEPAPTTPKKPAPT-TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 478

Query: 2273 LETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGR 2332
             +  A T   +P    P   A  T  + A   + E S + P+       +       +  
Sbjct: 479  PKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPA 538

Query: 2333 QKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEK-PH 2391
              TT+S     T  K  +P  +  P     +  +P   +      P+ P      E  P 
Sbjct: 539  PTTTKSAP---TTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT 595

Query: 2392 STPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPP--PPQPAPVDEEPQARFR 2449
            +T   + T+     P+T   +   + ++ TPT    P  L P  P +PAP   E  A   
Sbjct: 596  TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT---TPEKLAPTTPEKPAPTTPEELA--- 649

Query: 2450 VHSIIESDPVTP----PSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQ 2505
                    P TP    P+ P  P PT P   AA  +P   +   P +  PT   E     
Sbjct: 650  --------PTTPEEPTPTTPEEPAPTTPKA-AAPNTPKEPAPTTPKEPAPTTPKEPAPTT 700

Query: 2506 EEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVT------STSVTTAIA 2559
             +  A +TP    P   K     T      K L        TS T      +T   TA  
Sbjct: 701  PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT 760

Query: 2560 EPVSAAPCLHEAPPP---------------PVDSKKPLEEKTAPPVTNNSEIQASEVLVA 2604
             P   AP   + P P               P   KKP  ++ AP  T       S+    
Sbjct: 761  TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 820

Query: 2605 ADKEKVAPVIAPKITSVISRMPVSIDLENSQKIT--LAKPA----PQTLTGLVSALTGLV 2658
               ++ AP    +      + P     E     T  ++ P     P T+       T  +
Sbjct: 821  TTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPEL 880

Query: 2659 NVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVG-- 2716
            +    P      P +  V T K    TPA     +       T   ++ TTP   T    
Sbjct: 881  SAEPTPKALENSPKEPGVPTTK----TPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 936

Query: 2717 -TVNAAPGTVNAAASAVNATASAVT-----------VTAGAVTAASGGVTATTGTVTMAG 2764
             T   A  T     S + AT + VT           +T    T  +  VT T  T+T   
Sbjct: 937  MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE 996

Query: 2765 AVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQK- 2823
             +  P    K +  A  +    P        +P           +T +   +      K 
Sbjct: 997  IMNKPEETAKPKDRATNSKATTP--------KPQKPTKAPKKPTSTKKPKTMPRVRKPKT 1048

Query: 2824 TEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATH 2883
            T  P+++++ + ++ P S +     Q+ ++    P+S      P       AG A   T 
Sbjct: 1049 TPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK---SEDAGGAEGETP 1105

Query: 2884 STLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLV 2943
              L+                  RP +  PE       TP       +V  QGI      +
Sbjct: 1106 HMLL------------------RPHVFMPE------VTP-DMDYLPRVPNQGI------I 1134

Query: 2944 HNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPS 3003
             N ++   + +   K +    TL+  T V    +    L+P  PP+ P++  TEV  +PS
Sbjct: 1135 INPMLSDETNICNGKPVDGLTTLRNGTLVAFRGHYFWMLSPFSPPS-PARRITEVWGIPS 1193



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 191/944 (20%), Positives = 297/944 (31%), Gaps = 144/944 (15%)

Query: 1603 KPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKT 1662
            K   VE +E T  + +T     E K +  K   S+   S   +   S   A      + T
Sbjct: 280  KETTVETKETTTTNKQTSTDGKE-KTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETT 338

Query: 1663 VEAPLVTEEKTVEPATVSEEAKPA-SEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEE 1721
             + P +T  K   P T  E A     EP P  ++        P     K A   P     
Sbjct: 339  TKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAP 398

Query: 1722 GSSGD-------QPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKA 1774
             ++ +       +P     K P P  + S   +  +P P  T P  KPA  +     PK 
Sbjct: 399  TTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP--TTP-KKPAPTT-----PK- 449

Query: 1775 EKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVS 1834
             +P  T   EP      E AP ++ PA    +   P A K   P       TP + A   
Sbjct: 450  -EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT------TPKEPA--- 499

Query: 1835 IVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSL 1894
                P T K       K     +P+  A               T +K++    + P P+ 
Sbjct: 500  ----PTTPKEPAPTTTKEPSPTTPKEPAP--------------TTTKSAPTTTKEPAPTT 541

Query: 1895 PLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPP 1954
              S        S   T      + P     ++P  T  +           PTTP+   P 
Sbjct: 542  TKSAPTTPKEPSPTTT------KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT 595

Query: 1955 KTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEAT 2014
             T++ A        KEPA T  P E   +P + K      P+        K   T PE  
Sbjct: 596  TTKKPA----PTTPKEPAPT-TPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 648

Query: 2015 TEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSK 2074
                P+     +  EP     +A +          T K P  T P     K+PAP    +
Sbjct: 649  APTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP-----KEPAPTTPKE 703

Query: 2075 SKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLS 2134
            +                      A  +P+G A    +  +     +P+K    +     +
Sbjct: 704  T----------------------APTTPKGTAPTTLKEPA---PTTPKKPAPKELAPTTT 738

Query: 2135 SQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADA 2194
             +  S   D       +  + + P   A    K+              +  A    K  A
Sbjct: 739  KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 798

Query: 2195 PEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQ 2254
            P+ LAP     P    S+                EP   P  P  P  +  +  PP    
Sbjct: 799  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA--PTTPKKPAPTTPETPPPT--- 853

Query: 2255 ALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPE 2314
                      T E  +     E  T    P  + P+ SA PT  K    +  E      +
Sbjct: 854  ----------TSEVSTPTTTKEPTTIHKSPDESTPELSAEPT-PKALENSPKEPGVPTTK 902

Query: 2315 AKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTT 2374
               + + E+T   KDK  ++  R+  +  T     AP         +   E+    E TT
Sbjct: 903  TPAATKPEMTTTAKDKTTERDLRTTPETTT----AAP---------KMTKETATTTEKTT 949

Query: 2375 VQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPP 2434
                 A   +  S     T P   T+       T   + +++  ++T T   +   +  P
Sbjct: 950  ESKITATTTQVTSTTTQDTTPFKITT-----LKTTTLAPKVTTTKKTITTTEI---MNKP 1001

Query: 2435 PQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPI-----PTLPSVTAAKLSPP--VASG 2487
             + A    +P+ R          P  P   P  P       T+P V   K +P     + 
Sbjct: 1002 EETA----KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTS 1057

Query: 2488 GIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSS 2531
             +P  +P +++        E   Q+T  P   P++K  +V+  S
Sbjct: 1058 TMPELNPTSRIA-------EAMLQTTTRPNQTPNSKLVEVNPKS 1094



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 166/715 (23%), Positives = 244/715 (34%), Gaps = 96/715 (13%)

Query: 2820 SGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYAN 2879
            S ++T+  ++ SAK   + P S +  +       +   P   T  +P    P+ PA    
Sbjct: 306  SAKETQSIEKTSAK--DLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTP 363

Query: 2880 VATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTP 2939
                 T + +A T    P  ++ K+   + ++P P       P T        T+    P
Sbjct: 364  KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTK---EP 420

Query: 2940 PVLVHNQLVLTPS--IVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHP-PALPSK-LP 2995
                      TP     TT KK A P T K      +PA      TP  P P  P +  P
Sbjct: 421  APTTTKSAPTTPKEPAPTTPKKPA-PTTPK------EPA----PTTPKEPTPTTPKEPAP 469

Query: 2996 TEVNHVPSGPSIPADRTVSHLAAAKLDAHSP-RPSGPGPSSFPRASHPSSTASTALSTNA 3054
            T     P+ P  PA       A       +P  P  P P++    S P++    A +T  
Sbjct: 470  TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS-PTTPKEPAPTTTK 528

Query: 3055 TVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRP 3114
            +       P P    S            + T     S  +  E    TP  P+ T   +P
Sbjct: 529  SAPTTTKEPAPTTTKS------------APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKP 576

Query: 3115 EALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQ 3174
                +P  P +P     + P   +T +PAP      A   P E            TAP  
Sbjct: 577  ----APTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKE------------TAPTT 620

Query: 3175 SEVLVMQSEYRLHPY-------TVPRDVRIMVHPHVTAVSEQ------PRAADGVVKVPP 3221
             + L   +  +L P        T P ++        T  + +      P+AA       P
Sbjct: 621  PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 680

Query: 3222 ASKAPQQPG----KEAAKTPDAKAAPTPTPAPVPVPVPLPAPA----PAPHGEARILTVT 3273
            A   P++P     KE A T   + APT      P  +  PAP     PAP   A   T  
Sbjct: 681  APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKE 740

Query: 3274 PSNQL--QGLPLTP--PVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAAS 3329
            P++    +  P TP      T       +  E       G   T       T  + PA  
Sbjct: 741  PTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK 800

Query: 3330 SVGLPSRTK----TAAQGP----PPEGEPLQPPQPVQST--QPAQPAPPCPPSQLGQPGQ 3379
             +  P+ TK    T +  P    P E  P  P +P  +T  +PA   P  PP    +   
Sbjct: 801  ELA-PTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 859

Query: 3380 PPSSKMPQVSQEAKGTQTGVEQPRLPAGPA-----NRPPEPHTQVQRAQAETGPTSFPSP 3434
            P ++K P    ++    T    P L A P      N P EP     +  A T P    + 
Sbjct: 860  PTTTKEPTTIHKSPDEST----PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA 915

Query: 3435 VSVSMKPDLPVSLPTQT-APKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSP 3488
               + + DL  +  T T APK      TT+  +T   +    T+      QD++P
Sbjct: 916  KDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 970



 Score = 76.6 bits (187), Expect = 4e-13
 Identities = 113/519 (21%), Positives = 167/519 (32%), Gaps = 67/519 (12%)

Query: 2991 PSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTAL 3050
            P    T+ N V + P I   + ++           PRPS       P  S  S   S  +
Sbjct: 236  PDTSTTQHNKVSTSPKITTAKPIN-----------PRPS------LPPNSDTSKETSLTV 278

Query: 3051 STNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITY 3110
            +   TV         +  S+   E++         +  S   L+     +  PT P    
Sbjct: 279  NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT-PKAET 337

Query: 3111 SIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARAT 3170
            + +  AL +P+   +P     + P   +  +P P  + +  +   P+E      P    +
Sbjct: 338  TTKGPALTTPK---EPTPTTPKEPASTTPKEPTPTTIKSAPTT--PKEPA----PTTTKS 388

Query: 3171 APVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPG 3230
            AP   +     +     P T P++      P  T   E            P   AP  P 
Sbjct: 389  APTTPKEPAPTTTKEPAP-TTPKE------PAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 441

Query: 3231 KEAAKTPDAKAAPTP---TPAPVPVPVPL---PAPA----PAPHGEARILTVTPSNQLQG 3280
            K A  TP   A  TP   TP     P P    PAP     PAP    +    TP      
Sbjct: 442  KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 501

Query: 3281 LPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTA 3340
             P  P    T                +     T   PA  T    P  +    P+ TK+A
Sbjct: 502  TPKEPAPTTT----------------KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 545

Query: 3341 AQGPP-PEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGV 3399
               P  P     + P P    +PA   P  P     +   P + K P  +   K   T  
Sbjct: 546  PTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTP 605

Query: 3400 EQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSL--PTQTAPKQPL 3457
            ++P         P  P         +  PT+   P   + +   P +   PT T P++P 
Sbjct: 606  KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP- 664

Query: 3458 FVPTTSGPSTP--PGLVLPHTEFQPAPKQDSSPHLTSQR 3494
              PTT   + P  P    P T  +PAP     P  T+ +
Sbjct: 665  -APTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPK 702



 Score = 72.4 bits (176), Expect = 8e-12
 Identities = 123/587 (20%), Positives = 180/587 (30%), Gaps = 72/587 (12%)

Query: 1600 KDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTG 1659
            K+  P   +K   T      P +  E   +  K P    P      T +SAP+  ++   
Sbjct: 480  KEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP 539

Query: 1660 DKTVEAPLVTEE----KTVEPA-TVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAM 1714
              T  AP   +E     T EPA T  +E  P +   PAP    E     P  +P      
Sbjct: 540  TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP-KEPAPTTTK 598

Query: 1715 MPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKA 1774
             PA           P  +  P TP     +  +   PE  +     KPA  + E   P  
Sbjct: 599  KPAPTTPKEPAPTTP-KETAPTTP-----KKLTPTTPEKLAPTTPEKPAPTTPEELAPTT 652

Query: 1775 -EKPDATADAEPDANQKAEAAPES-QPPASEDLEVDPPVAAKDKKPNKSKRS--KTPVQA 1830
             E+P  T   EP       AAP + + PA    +   P   K+  P   K +   TP   
Sbjct: 653  PEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 712

Query: 1831 AAVSIVE--------------KPVTRKSERIDREKLKRSNSPRGEA---QKLLELKMEAE 1873
            A  ++ E               P T K             +P+G A    K        E
Sbjct: 713  APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 772

Query: 1874 KITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKR 1933
                T    +   L+ P P+ P     +         +     + P     ++P  T  +
Sbjct: 773  PAPTTPKGTAPTTLKEPAPTTPKKPAPKE--------LAPTTTKGPTSTTSDKPAPTTPK 824

Query: 1934 LERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGG 1993
                       PTTP+  +P  T         +E   P  T +P    +SP         
Sbjct: 825  ETAPTTPKEPAPTTPK--KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 882

Query: 1994 GPQGKKGKNEPK---VDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGT 2050
             P  K  +N PK   V  T+  A T+                 E    ++ K   +D  T
Sbjct: 883  EPTPKALENSPKEPGVPTTKTPAATK----------------PEMTTTAKDKTTERDLRT 926

Query: 2051 DKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVD-------KSASLKNVDAAVSPR 2103
                   AP    E     EK ++SK   +     +         K  +LK    A    
Sbjct: 927  TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 986

Query: 2104 GAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEK 2150
                     E   +   PE++  P+     S      P  P K P+K
Sbjct: 987  TTKKTITTTE---IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKK 1030



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 231/1166 (19%), Positives = 360/1166 (30%), Gaps = 162/1166 (13%)

Query: 2392 STPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDE--EPQARFR 2449
            ++PP S      K P    +SQ I    ++ TK S     P PP      +  E +    
Sbjct: 111  TSPPSS-----KKAPPPSGASQTI----KSTTKRS-----PKPPNKKKTKKVIESEEITE 156

Query: 2450 VHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPR 2509
             HS+ E+   +  S  S    T+  + ++K S         ++    K+     ++   +
Sbjct: 157  EHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAA-------NRELQKKLKVKDNKKNRTK 209

Query: 2510 AQSTPSPALPP---------DTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAE 2560
             + TP P +           D K +  DTS++   K+   PK           +TTA  +
Sbjct: 210  KKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPK-----------ITTA--K 256

Query: 2561 PVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAAD------KEKVAPVI 2614
            P++  P L    PP  D+ K    +T+  V   + ++  E            KEK     
Sbjct: 257  PINPRPSL----PPNSDTSK----ETSLTVNKETTVETKETTTTNKQTSTDGKEKTT--- 305

Query: 2615 APKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKG 2674
            + K T  I +     DL  + K+ LAKP P+  T                  AL  P + 
Sbjct: 306  SAKETQSIEKTSAK-DLAPTSKV-LAKPTPKAETTTKGP-------------ALTTPKEP 350

Query: 2675 SVTTLKSLVST-PAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVN 2733
            + TT K   ST P  P      P  + + P    TTP      T  +AP T    A    
Sbjct: 351  TPTTPKEPASTTPKEPT-----PTTIKSAP----TTPKEPAPTTTKSAPTTPKEPAPTTT 401

Query: 2734 ATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVI 2793
               +  T    A T        TT +        AP+T  K                P  
Sbjct: 402  KEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPA--------------PTT 447

Query: 2794 DDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSK 2853
               PA             E           T      +A     P         ++    
Sbjct: 448  PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTP------KEPAPT 501

Query: 2854 SQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPE 2913
            +  +P   T  +P    P+ PA         T   +A T    P  ++ K+   + ++P 
Sbjct: 502  TPKEPAPTTTKEPSPTTPKEPA--------PTTTKSAPTTTKEPAPTTTKSAPTTPKEPS 553

Query: 2914 PIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPS--IVTTNKKLADPVTLKIETK 2971
            P       P T         +     P         TP     TT KK A P T K E  
Sbjct: 554  PTTTKEPAPTTPKEPAPTTPK--KPAPTTPKEPAPTTPKEPAPTTTKKPA-PTTPK-EPA 609

Query: 2972 VLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPR-PSG 3030
               P     T      P  P KL       P+ P  PA  T   LA    +  +P  P  
Sbjct: 610  PTTPKETAPTTPKKLTPTTPEKL------APTTPEKPAPTTPEELAPTTPEEPTPTTPEE 663

Query: 3031 PGPSSFPRASHPSSTASTALST-NATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVS 3089
            P P++ P+A+ P++    A +T           P P       P       P ++ +   
Sbjct: 664  PAPTT-PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP 722

Query: 3090 LSHLSQG--EVRMNTPTLPSITYSIRPEALHSPR--APLQPQQIEVRAPQRASTPQPAPA 3145
             +       E+   T   P+ T   +P A  +P+  AP  P++     P+  +   P   
Sbjct: 723  TTPKKPAPKELAPTTTKEPTSTTCDKP-APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGT 781

Query: 3146 GVPALASQHP--PEEEVHYHLPVARATAPVQ--SEVLVMQSEYRLHPYTVPRDVRIMVHP 3201
                L    P  P++     L       P    S+     +     P T           
Sbjct: 782  APTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKK 841

Query: 3202 HVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAK-TPDAKAAPTP-----TPAPVPVPVP 3255
                  E P      V  P  +K P    K   + TP+  A PTP     +P    VP  
Sbjct: 842  PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTT 901

Query: 3256 LPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYH 3315
                A  P         T    L+    T P   T   ++   +    ++     I    
Sbjct: 902  KTPAATKPEMTTTAKDKTTERDLR----TTPETTTAAPKMTKETATTTEKTTESKITATT 957

Query: 3316 PPAQLTHTQFPAASSVGLPSRTKTAAQGPPPE---------GEPLQPPQPVQSTQPAQPA 3366
                 T TQ      +     T  A +    +          +P +  +P      ++  
Sbjct: 958  TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 1017

Query: 3367 PPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAET 3426
             P P      P +P S+K P+     +  +T     ++ +      P         Q  T
Sbjct: 1018 TPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTT 1077

Query: 3427 GPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGL-VLPHTEFQPA---P 3482
             P   P+   V + P    +   +      L  P    P   P +  LP    Q     P
Sbjct: 1078 RPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINP 1137

Query: 3483 KQDSSPHLTSQRPVDMVQLLKKYPIV 3508
                  ++ + +PVD +  L+   +V
Sbjct: 1138 MLSDETNICNGKPVDGLTTLRNGTLV 1163



 Score = 60.5 bits (145), Expect = 3e-08
 Identities = 190/979 (19%), Positives = 307/979 (31%), Gaps = 99/979 (10%)

Query: 2360 NQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEE 2419
            N+ + +    +E  T +H  +  +E  S    S+   S +S + KI S++NS+    +++
Sbjct: 141  NKKKTKKVIESEEITEEHSVSENQESSS----SSSSSSSSSTIRKIKSSKNSAANRELQK 196

Query: 2420 RTPTKASVP--PDLPPPPQPAPVDEE-------------PQARFRVHSIIESDPVTPPSD 2464
            +   K +        P P+P  VDE              P      H+ + + P    + 
Sbjct: 197  KLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAK 256

Query: 2465 PSIPIPTLP--SVTAAKLSPPVASGGIPHQSPPT---KVTEWITRQEEPRAQST------ 2513
            P  P P+LP  S T+ + S  V           T   K T    +++   A+ T      
Sbjct: 257  PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKT 316

Query: 2514 --------------PSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIA 2559
                          P+P     TK   + T          +P   +    T T++ +A  
Sbjct: 317  SAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT 376

Query: 2560 EPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKIT 2619
             P   AP   ++ P       P   K   P T       +    A    K AP    +  
Sbjct: 377  TPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 436

Query: 2620 SVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVN-ALKGPVKGSVTT 2678
                + P     +     T  +P P   T    A T        P   A   P K + TT
Sbjct: 437  PTTPKKPAPTTPKEPAPTTPKEPTP--TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTT 494

Query: 2679 LKS-LVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATAS 2737
             K    +TP  P        +  T      TT  +A   T   AP T  +A +     + 
Sbjct: 495  PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 554

Query: 2738 AVTVTAGAVTAASGGVTATTGTVTMAGAVIAPST-KCKQRASANENSRFHPGSMPVIDDR 2796
              T      T      T             AP+T K     +  + +   P        +
Sbjct: 555  TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPK 614

Query: 2797 PADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIP----PASAMDIEFQQSVS 2852
                 +   L   T E +   +        P+ ++    + P    P        + +  
Sbjct: 615  ETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP 674

Query: 2853 KSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSL-EK 2911
             +  +P   T  +P    P+ PA        +T   TA T       +++K   P+  +K
Sbjct: 675  NTPKEPAPTTPKEPAPTTPKEPA-------PTTPKETAPTTPKGTAPTTLKEPAPTTPKK 727

Query: 2912 PEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETK 2971
            P P  L+ +T  T+  T     +   T P               T  K   P T K E  
Sbjct: 728  PAPKELAPTT--TKEPTSTTCDKPAPTTP----------KGTAPTTPKEPAPTTPK-EPA 774

Query: 2972 VLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGP 3031
               P     T      P  P K P      P+    P   T    A       +P+ + P
Sbjct: 775  PTTPKGTAPTTLKEPAPTTPKK-PAPKELAPTTTKGPTSTTSDKPAPT-----TPKETAP 828

Query: 3032 GPSSFPRASHPSSTASTALSTNATVMLAAGIP-VPQFISSIHPEQSVIMPPHSITQTVSL 3090
                 P  + P   A T   T          P   +  ++IH       P  S   T   
Sbjct: 829  TTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKA 888

Query: 3091 SHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPAL 3150
               S  E  + T   P+ T   +PE   +  A  +  + ++R     +T  P      A 
Sbjct: 889  LENSPKEPGVPTTKTPAAT---KPEM--TTTAKDKTTERDLRTTPETTTAAPKMTKETAT 943

Query: 3151 ASQHPPEEEVHYHLPVARATAPVQS---EVLVMQSEYRLHPYTVPR----DVRIMVHPHV 3203
             ++   E ++        +T    +   ++  +++       T  +       IM  P  
Sbjct: 944  TTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEE 1003

Query: 3204 TAVSEQPRAADGVVKVP---PASKAPQQP-GKEAAKTPDAKAAPTPTPAPVPVPVPLPAP 3259
            TA   + RA +     P     +KAP++P   +  KT      P  TP P  +   +P  
Sbjct: 1004 TA-KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPEL 1062

Query: 3260 APAPH-GEARILTVTPSNQ 3277
             P     EA + T T  NQ
Sbjct: 1063 NPTSRIAEAMLQTTTRPNQ 1081



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 6/91 (6%)

Query: 250 SRNQSPQRLASQASRPT--RSPSGSGSRSRSS--SSDSISSSSSTSS--DSSDSSSSSSD 303
           S+   P   ASQ  + T  RSP     +       S+ I+   S S   +SS SSSSSS 
Sbjct: 116 SKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSS 175

Query: 304 DSPARSVQSAAVPAPTSQLLSSLEKDEPRKS 334
            S  R ++S+   A   +L   L+  + +K+
Sbjct: 176 SSTIRKIKSSKNSAANRELQKKLKVKDNKKN 206


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score =  106 bits (264), Expect = 5e-22
 Identities = 341/1673 (20%), Positives = 576/1673 (34%), Gaps = 273/1673 (16%)

Query: 1620 PESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPA-- 1677
            PES+   KD+ L+TPP     + +    +   SAL  ++ D+ +   +   EK+ EPA  
Sbjct: 1196 PESSLVFKDT-LRTPPRERSGAGSSPETKEQNSALPTSSQDEEL---MEVVEKSEEPAGQ 1251

Query: 1678 TVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPT 1737
             +S  +    E + +  E   +V+  P      + +   A +E             + P+
Sbjct: 1252 ILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEA-----------VEVPS 1300

Query: 1738 PGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPES 1797
              +S+     + + +  S  PL     +      P   +       E +    +E   + 
Sbjct: 1301 MASSWGGPHFSPEHKELSNSPL-----RENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDL 1355

Query: 1798 QPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNS 1857
              P    LE DP +  K++    S  S + +   AV   EK     ++ I    L     
Sbjct: 1356 NGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAV---EKAGMSSNQSISSPVL----- 1407

Query: 1858 PRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENR 1917
                           + + RT S+  ++    PE    L RT  R  RS           
Sbjct: 1408 ---------------DAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRS---------GS 1443

Query: 1918 SP-VKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLK 1976
            SP +++    P  +R  L         +P TP RGR       ++ +   E K   +T +
Sbjct: 1444 SPGLRDGSGTP--SRHSLSGSSPGMKDIPRTPSRGR-------SECDSSPEPKALPQTPR 1494

Query: 1977 PPEGWRSPRSQKTAAGG-GPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEE 2035
            P    RSP S +       PQ ++  +E  VD  +  A T +G +     S    +   +
Sbjct: 1495 PRS--RSPSSPELNNKCLTPQRERSGSESSVDQ-KTVARTPLGQR---SRSGSSQELDVK 1548

Query: 2036 EAGSEQKRDRKDAGTDKNPPETAPVEVVEKK-PAPEKNSKSK----RGRSRNSRLAVDKS 2090
             + S Q+R   D+  D       P+    +   +PE +SKS+    R RS +S    DK 
Sbjct: 1549 PSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKP 1608

Query: 2091 ASLKNV----DAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDK 2146
             +        D++  P+  A +A  R S   + S  +  SP+     SS  +S P  P K
Sbjct: 1609 RAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEG----SSSTESSPEHPPK 1664

Query: 2147 EPEKEDVSASGPSPEATQLA----KQMELEQAVEHIAKLAEASASAAYKADAPEGLAPED 2202
                   S S P P+         +       +   A+L+  S SA+   +      P  
Sbjct: 1665 SRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRH 1724

Query: 2203 RDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEG 2262
            R  P+  + E    +         S       + P     S+    P    + LQ S   
Sbjct: 1725 RRSPSVSSPEPAEKSR--------SSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSR 1776

Query: 2263 METDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVE 2322
               ++  +      + +  S         S     T+  RG S   S S    + S+   
Sbjct: 1777 SRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRV-TRRRRGGSGYHSRSPARQESSR--- 1832

Query: 2323 VTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHP---- 2378
             T  R+ +GR +T  + RKR+ ++       S  P        SPA +  +  + P    
Sbjct: 1833 -TSSRRRRGRSRTPPTSRKRSRSRT------SPAPWKRSRSRASPATHRRSRSRTPLISR 1885

Query: 2379 ------EAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISV-----EERTPTKASV 2427
                   +P   ++S    S   +   S  S +    + S+   V       RTPT    
Sbjct: 1886 RRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRR 1945

Query: 2428 PPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASG 2487
                 PP              R  S   + P+T     S   P     + ++ SP     
Sbjct: 1946 SRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRR 2005

Query: 2488 GIPHQSPPTK------VTEWITRQEEPRAQSTP-------SPALPPDTKASDVDTSSSTL 2534
                 SP T+          I R+   R    P       SP        S    ++   
Sbjct: 2006 SRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGK 2065

Query: 2535 RKILMDPKYVSATSVTSTSV--TTAIAEPVSAAPCLHEAPPPPVDSKK------------ 2580
            R +   P  +   S + +S   + +   P +        PP  ++S +            
Sbjct: 2066 RSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPT 2125

Query: 2581 PLEEKTAPPVTN---NSEIQASEVLVAADKEKVAPVIAPKI-----TSVI---SRMPVSI 2629
            PL+   +P +     +S    S +  A       P   P+I     TSV    ++  +++
Sbjct: 2126 PLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGP--GPRIPDHQRTSVPENHAQSRIAL 2183

Query: 2630 DLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGP 2689
             L      T   P   +  GL + ++ +   + VP+ +L+     ++ +   + +  A  
Sbjct: 2184 ALTAISLGTARPPPSMSAAGLAARMSQVP--APVPLMSLRTAPAANLAS--RIPAASAAA 2239

Query: 2690 VNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNA------TASAVTVTA 2743
            +N+       +   VN+  +   A    +N A      A SAVN       TA AV + A
Sbjct: 2240 MNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNL-A 2298

Query: 2744 GAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANEN-----------------SRFH 2786
            GA T A+    + TG+ T   A   PS+    +A A+ N                 SR  
Sbjct: 2299 GARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTA 2358

Query: 2787 PGSMP--VIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMD 2844
                P  +   R A A SGA L   TS  V L +Y        +R+S + S  PP     
Sbjct: 2359 AALAPASLTSARMAPALSGANL---TSPRVPLSAY--------ERVSGRTS--PPLLDR- 2404

Query: 2845 IEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKA 2904
                   ++S+  P + + S+  S+   +P+     A   +L+  AQ    SPV S+   
Sbjct: 2405 -------ARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSD 2457

Query: 2905 DRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADP- 2963
                L       ++ +TPV    ++        T     HN ++  P+    +  + +P 
Sbjct: 2458 QSRCL-------IAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPP 2510

Query: 2964 ----VTLKIETKVLQPA----------------NLGSTLTPHHPPALPSKLPTEVNHVPS 3003
                         LQPA                +  S+ +     +  S   +E + +P 
Sbjct: 2511 ASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPV 2570

Query: 3004 GPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIP 3063
             P +   R  S   A K      RP  P P+   R S  SS++S++ S++++   ++   
Sbjct: 2571 QPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSS 2630

Query: 3064 VPQFISSIHPEQSVIMP--------PHSITQTVSLSHLSQGEVRMNTPTLP--------S 3107
                 SS     S            P ++ +  S      GE R  +P  P        S
Sbjct: 2631 SSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRS 2690

Query: 3108 ITYS----IRPEALHSP---------RAPLQPQQIEVRAP---QRASTPQPAP 3144
            ++YS     RP    SP         R   + Q+ + R+P   +R  TP P P
Sbjct: 2691 LSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRP 2743



 Score =  100 bits (249), Expect = 3e-20
 Identities = 255/1159 (22%), Positives = 405/1159 (34%), Gaps = 200/1159 (17%)

Query: 1592 RMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSV--GPPSVTVVTLES 1649
            R ++K+  K +K +   + +  ++   TP+S  ++KD + K   S    P S       S
Sbjct: 206  RRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTS 265

Query: 1650 APSALEKTT--------GDKTVEAPLVTEEKTVEPATVSEEAKPASEPA------PAPVE 1695
            A SA    T          KT    L     +       E   P SEP       P+  E
Sbjct: 266  ADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPE 325

Query: 1696 QLEQVDLPPGADPDKE----AAMMPA-GVEEGSSGDQPPYLDAKPPTPGASFSQAESNVD 1750
               +    P  D DK+    +A  P+   E  S+G +PP      PTP  +     S   
Sbjct: 326  TATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPP-----APTPLLAERHGGS--- 377

Query: 1751 PEPDSTQPLS-KPAQKSEEANEPKAEKPDATADAEPDA---------------NQKAEAA 1794
            P+P +T PLS +P     EA+  +   P  + +  P +               ++ A ++
Sbjct: 378  PQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSS 437

Query: 1795 PESQPPA---SEDLEVDPPVAAKDKKPNKSKRSK----TPVQAAAVSIVEKPVTRKSERI 1847
            PES  PA       E+     +K++   ++KR K    TP +    S    P T K  R 
Sbjct: 438  PESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRS--RSPATAKRGRS 495

Query: 1848 -DREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPE-PSLPLSRTRRRNVR 1905
              R   KR +S     Q        A++  R+ S         P+ P    SR  +R  R
Sbjct: 496  RSRTPTKRGHSRSRSPQ--WRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGR 553

Query: 1906 SVYATMGDHENRSPV-------KEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRR 1958
            S  A  G   +RSP        + P  + R +R R     +  +  PT  RR R     R
Sbjct: 554  SRSARRGRSHSRSPATRGRSRSRTPARRGR-SRSRTPARRRSRSRTPTR-RRSRSRTPAR 611

Query: 1959 RADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGG----------------PQGKKGKN 2002
            R        A+  + T  P    R  RS+  A   G                   ++G++
Sbjct: 612  RGRSRSRTPARRRSRTRSPVR--RRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRS 669

Query: 2003 EPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPET-APVE 2061
              +  A R   +    P    +  S  P+     + S  +R R  + T +    + +  E
Sbjct: 670  RSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSE 729

Query: 2062 VVEKKPAPEKNSKSKRG-RSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVS 2120
               K    ++ S+S      + SR++  +S SL       SPR  A         +   S
Sbjct: 730  RKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLS------SPRSKAKSRLSLRRSLSGSS 783

Query: 2121 P---EKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEH 2177
            P   +KS++P +     S   S P    + P +   S+S P P           +Q  + 
Sbjct: 784  PCPKQKSQTPPRRSRSGS---SQPKAKSRTPPRRSRSSSSPPP-----------KQKSKT 829

Query: 2178 IAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPP 2237
             ++ + +S+S   K  +  G  P      + QA+E  +     S   + S +PE     P
Sbjct: 830  PSRQSHSSSSPHPKVKS--GTPPRQGSITSPQANEQSVTPQRRSCF-ESSPDPELKSRTP 886

Query: 2238 PYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTD 2297
                 S +   PP                             +SS PP  +P  S+ P  
Sbjct: 887  --SRHSCSGSSPP---------------------------RVKSSTPPRQSPSRSSSPQP 917

Query: 2298 TKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESH-V 2356
              +A  +  + SHS   +     V             T+R+  +R+ +    + VES  +
Sbjct: 918  KVKAIISPRQRSHSGSSSPSPSRV-------------TSRTTPRRSRSVSPCSNVESRLL 964

Query: 2357 PESNQAQGESPAANEGTTVQHPEAP--QEEKQSEKPH-----STPPQSCTSDLSKIPSTE 2409
            P  + +   SP      T   PE P  Q    S  P+      TPP    S  SK P  +
Sbjct: 965  PRYSHSGSSSP-----DTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSG-SKSPCPQ 1018

Query: 2410 NSSQEISVEE---RTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPS 2466
              S++  V+         A V    PP      V      + +  S    D  +  S P 
Sbjct: 1019 EKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVS---SLQLKGQSQTSPDHRSDTSSPE 1075

Query: 2467 IPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQ--EEPRAQSTPSPAL----PP 2520
            +      S +    S     GG    S P  VTE  +R    + R + + SP L     P
Sbjct: 1076 VRQSHSESPSLQSKSQTSPKGGRSRSSSP--VTELASRSPIRQDRGEFSASPMLKSGMSP 1133

Query: 2521 DTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEA---PPPPVD 2577
            +      D+SS         P   S + +  + + TA ++   A P   +A   PP   D
Sbjct: 1134 EQSRFQSDSSSY--------PTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKD 1185

Query: 2578 SKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKI 2637
               P   +  P     S +   + L    +E+     +P+     S +P S   E   ++
Sbjct: 1186 KFSPFPVQDRP----ESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEV 1241

Query: 2638 T--LAKPAPQTLTGLVSAL 2654
                 +PA Q L+ L S L
Sbjct: 1242 VEKSEEPAGQILSHLSSEL 1260



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 293/1517 (19%), Positives = 530/1517 (34%), Gaps = 186/1517 (12%)

Query: 693  REYSYRQRERERERERFESDRDRDHE-RRPIERSQSPVHLRRPQSPGASPSQAERLPSDS 751
            RE S     + R   R + D+   H   R + RS+SP   +R +S   +P++     S S
Sbjct: 451  REISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRS 510

Query: 752  ERRLYSRSSDRSGSCSS-------LSPPR--------YEKLDKSRLERYTKNEKTD---- 792
             +   SRS+ R G   S        SP R         ++  +SR  R  ++        
Sbjct: 511  PQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATR 570

Query: 793  -KERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPS----SQSSETDQENEREQS 847
             + R+  P R  R R      +  + +T   +R+ +  +P+    S+S    +   R +S
Sbjct: 571  GRSRSRTPARRGRSRSRTPARRRSRSRTPT-RRRSRSRTPARRGRSRSRTPARRRSRTRS 629

Query: 848  PEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDT 907
            P + RS    SR  A + G +++R         +R   + G+    TP  +         
Sbjct: 630  PVRRRS---RSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTP 686

Query: 908  VKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRL---KARKHL 964
             +      +        ++S + +  S   + P+ +G S      + + R    ++R + 
Sbjct: 687  ARRGRSRSRTPRRGRSRSRSLVRRGRS-HSRTPQRRGRSGSSSERKNKSRTSQRRSRSNS 745

Query: 965  KPEQPADGVSA-----VDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQ 1019
             PE     +S+     +   + +A+ R     +L      P+ K  +P           Q
Sbjct: 746  SPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRS--GSSQ 803

Query: 1020 PDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSR 1079
            P   SR     R   +   P  K+  K  S++      ++ +SP          V SG+ 
Sbjct: 804  PKAKSRTPP--RRSRSSSSPPPKQKSKTPSRQS-----HSSSSPHP-------KVKSGTP 849

Query: 1080 PSSDLQARLGELAGESVENQEV--QSKKPIPSKPQLKQLQVLDDQGPEREDVR-KNYCSL 1136
            P      R G +       Q V  Q +    S P  +    L  + P R      +   +
Sbjct: 850  P------RQGSITSPQANEQSVTPQRRSCFESSPDPE----LKSRTPSRHSCSGSSPPRV 899

Query: 1137 RDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPK 1196
            +  TP R+S    S S + + K+   I   Q            +       +  +  SP 
Sbjct: 900  KSSTPPRQS---PSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPC 956

Query: 1197 KDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSE 1256
             +V+        H     P        P ++     +           Y   +  +    
Sbjct: 957  SNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSIS---------PYPKVKAQTPPGP 1007

Query: 1257 RTGGSPSVRHGSFHEDEDPIGSPRLLS----VKGSPKVDEKVLPYSNITVREESLKFNPY 1312
               GS S       +D      P  LS    VK S    E     S++ ++ +S      
Sbjct: 1008 SLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQS------ 1061

Query: 1313 DSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFP------NSIIKRDSLR 1366
              +  +  +D +  ++   +SE    +  SQ     GR   S P       S I++D   
Sbjct: 1062 -QTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGE 1120

Query: 1367 KRSVRDLEPGEVPSDSDEDGEHKSH-SPRASALYESSRLSFLLRDREDKLR---ERDERL 1422
              +   L+ G  P  S    +  S+ +  +++L   SRL     + ++K+    + D   
Sbjct: 1121 FSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLE--TAESKEKMALPPQEDATA 1178

Query: 1423 SSSLERNKFYSFALD-----KTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNN 1477
            S   +++KF  F +        +  DT     R +S + S  E     + +S       +
Sbjct: 1179 SPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPET---KEQNSALPTSSQD 1235

Query: 1478 KD-KEKVDSAPRP---IPSWYMKKKKIRTDSEGKMDDKKEDH--------KEEEQERQEL 1525
            ++  E V+ +  P   I S    + K  + S  +   + E+         + + Q   E 
Sbjct: 1236 EELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEA 1295

Query: 1526 FASRFLHSSI----FEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVV 1581
                 + SS     F  + K L +   +E  + F S   +      G    T    E   
Sbjct: 1296 VEVPSMASSWGGPHFSPEHKELSNSPLRE--NSFGSPLEFRNSGPLGTEMNTGFSSEVKE 1353

Query: 1582 LFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPS 1641
              +  F+           K+Q  +       +E  P   E A  + +  + +P     P 
Sbjct: 1354 DLNGPFLNQLETDPSLDMKEQSTRS-SGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPR 1412

Query: 1642 VTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVD 1701
                + E + SA      D     P         P        P+          ++ + 
Sbjct: 1413 TP--SRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIP 1470

Query: 1702 LPPG-----ADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDST 1756
              P       D   E   +P      S     P L+ K  TP    S +ES+VD +  + 
Sbjct: 1471 RTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVAR 1530

Query: 1757 QPLSKPAQ--KSEEANEPKAEKPD--ATADAEPDANQKAEAAPESQPPASEDLEVDPPVA 1812
             PL + ++   S+E +   +  P   + +D+ PD+  K       +  +    EVD   +
Sbjct: 1531 TPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVD---S 1587

Query: 1813 AKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEA 1872
                 P +S+   +P       + +KP  R + R  +     S  P+  A + L  +  +
Sbjct: 1588 KSRLSPRRSRSGSSP------EVKDKP--RAAPRA-QSGSDSSPEPKAPAPRALPRRSRS 1638

Query: 1873 EKITR------TASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQ 1926
               ++        S ++ +  EHP    P SRT RR  RS  +     ++R+P +    +
Sbjct: 1639 GSSSKGRGPSPEGSSSTESSPEHP----PKSRTARRGSRS--SPEPKTKSRTPPRRRSSR 1692

Query: 1927 --PRVTRK-RLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRS 1983
              P +TRK RL R  + A++ P T  R R P   RR+      E  E + + +      S
Sbjct: 1693 SSPELTRKARLSRRSRSASSSPET--RSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASS 1750

Query: 1984 PRSQKTAAGG-----GPQG-KKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEA 2037
            PR++ T+  G      P+G ++ ++  + + TR   TT    + G  +S+   +      
Sbjct: 1751 PRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTR---TTRRRDRSGSSQSTSRRRQRSRSR 1807

Query: 2038 GSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVD 2097
                +R R  +G     P         ++ +   +S+ +RGRSR    +  +S S  +  
Sbjct: 1808 SRVTRRRRGGSGYHSRSP--------ARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPA 1859

Query: 2098 AAVSPRGAAAQAGERES 2114
                 R  A+ A  R S
Sbjct: 1860 PWKRSRSRASPATHRRS 1876



 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 244/1220 (20%), Positives = 414/1220 (33%), Gaps = 167/1220 (13%)

Query: 1564 QTSEGANSTTDSIQEPVVLFH-----SRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPK 1618
            +T     S  DS  EP  L       SR      +  K     ++    E   D +   +
Sbjct: 1471 RTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVAR 1530

Query: 1619 TP--ESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTG-----DKTVEAPLVTEE 1671
            TP  + +      EL   PS  P   +    +S+P +  KT        ++  +P V  +
Sbjct: 1531 TPLGQRSRSGSSQELDVKPSASPQERS--ESDSSPDSKAKTRTPLRQRSRSGSSPEVDSK 1588

Query: 1672 KTVEPATVSEEAKPA--SEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSS----G 1725
              + P      + P    +P  AP  Q      P    P   A  +P     GSS    G
Sbjct: 1589 SRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRA--LPRRSRSGSSSKGRG 1646

Query: 1726 DQPP---YLDAKPPTPGAS-FSQAESNVDPEPDS---TQPLSKPAQKSEE-ANEPKAEKP 1777
              P      ++ P  P  S  ++  S   PEP +   T P  + ++ S E   + +  + 
Sbjct: 1647 PSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRR 1706

Query: 1778 DATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAA-AVSIV 1836
              +A + P+   +        P  S     +   +++ ++   S R+KT  +   + S  
Sbjct: 1707 SRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPK 1766

Query: 1837 EKPVTRKSERIDREKLK------RSNSPRGEAQKLLELKMEA------------------ 1872
             + + R   R  REK +      RS S +  +++    +  +                  
Sbjct: 1767 PRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPA 1826

Query: 1873 -EKITRTASKNSAADLEHPEPSLPLSRTR-------RRNVRSVYATMGDHENRSPV---- 1920
             ++ +RT+S+        P  S   SR+R       R   R+  AT     +R+P+    
Sbjct: 1827 RQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRR 1886

Query: 1921 -----KEPVEQPR------VTRKR-------LERELQEAAAVPTTPRRGRP--PKTRRRA 1960
                   PV + R      VTR+R       + R    +   P T RR R   P TRRR+
Sbjct: 1887 RSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRS 1946

Query: 1961 DEEEENEAKEPAETLKPPEGWRSPRS-------QKTAAGGGPQGKKGKNEPKVDATRPEA 2013
                    +  + +  PP   R  RS       +++ +   P  ++         TR  +
Sbjct: 1947 RSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRS 2006

Query: 2014 TTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEK-KPAPEKN 2072
             +   P    +  S  P A        + R R      K     +P+ +  + +    + 
Sbjct: 2007 RSRTSPVTRRRSRSRTPPAIR-----RRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRT 2061

Query: 2073 SKSKRGRSRNSRLAVDKSASLKNVD--AAVSPRGAAAQAGER------ESGVVAVSPEKS 2124
            ++ KR  +R+      +SAS  + D   + +P      +G R       S  ++     S
Sbjct: 2062 ARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPS 2121

Query: 2125 ESPQKEDGLSSQLKSDPVDPDKEP-----EKEDVSASGPSPEATQLAKQMELEQAVEHIA 2179
             SP   D   S    +P+   + P     +       GP P      +    E   +   
Sbjct: 2122 MSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHQRTSVPENHAQSRI 2181

Query: 2180 KLAEASASAAYKADAPE----GLAPEDRDKPAH---QASETELAAAIGSIINDISGEPEN 2232
             LA  + S       P     GLA      PA     +  T  AA + S I   S    N
Sbjct: 2182 ALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMN 2241

Query: 2233 FPA--PPPYP-GESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAP 2289
              +   P  P   +  D + PA A A+  +        +   + +    T  +     A 
Sbjct: 2242 LASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGAR 2301

Query: 2290 DPSA---------GPTDTKEARGNSSETSHSVPEAK--GSKEVEVTLVRKDKGRQKTTRS 2338
             P+A         G   T     +SS T  +   A   G +    T      G  +T  +
Sbjct: 2302 TPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAG-SRTAAA 2360

Query: 2339 RRKRNTNKKVVAPVESHVPESNQAQGESP-AANEGTTVQHPEAPQEEKQSEKPHSTPPQS 2397
                +     +AP  S    +N      P +A E  + +      +  +S  P S P QS
Sbjct: 2361 LAPASLTSARMAPALS---GANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQS 2417

Query: 2398 -CTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIES 2456
              TS+ +  PS+           + P+++ +PP    P  P P     Q+R     I ++
Sbjct: 2418 RMTSERAPSPSSRMG--------QAPSQSLLPPAQDQPRSPVPSAFSDQSRC---LIAQT 2466

Query: 2457 DPVTPPSDPSIPIPTLPSVTAAKLSP--PVASGGIPHQ---SPPTKVTEWITRQEEPRAQ 2511
             PV      S       + +A   +    V + G+PH     PP       T  ++P A 
Sbjct: 2467 TPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPAS-----TGAQQPSAL 2521

Query: 2512 STPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEA 2571
            +   PA   + ++S   +SSS+           S++S +S+S +   + PV     L   
Sbjct: 2522 AALQPA--KERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRV 2579

Query: 2572 PPPPVDSKKPLEEKTAPPVT----NNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPV 2627
            P P    K+ + E   P  T          +S    ++     +   +   +S  S    
Sbjct: 2580 PSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2639

Query: 2628 SIDLENSQKITLAKPAPQTL 2647
            S    +S   + AKP PQ L
Sbjct: 2640 SSSSSSSSSPSPAKPGPQAL 2659



 Score = 73.2 bits (178), Expect = 5e-12
 Identities = 350/1832 (19%), Positives = 598/1832 (32%), Gaps = 293/1832 (15%)

Query: 796  TFDPERVERERR-----------LIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQENER 844
            +FDP+R  RE +           L+R+    +  T KQK+K K      +S  +    ER
Sbjct: 150  SFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRER 209

Query: 845  EQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEK-LKAKL 903
            ++S +K        + +++ E   +      P        +K  +    TP  K  +A  
Sbjct: 210  KKSSKK-------KKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHR 262

Query: 904  DNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKH 963
                  +S+ D     S++  AK+  + L   R   P             + G    ++ 
Sbjct: 263  STSADSASSSDTSRSRSRSAAAKTHTTALAG-RSPSPASGRRGEGDAPFSEPGTTSTQRP 321

Query: 964  LKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQPDVS 1023
              PE               A K+    S+   +K K + +KS+     +   S   P+  
Sbjct: 322  SSPE--------------TATKQ---PSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPP 364

Query: 1024 SREVILLREGEAERKPVRKEILKRESKKIKLDRLNT-VASPKDCQELASISVGSGSRPSS 1082
            +   +L        +P+    L +E      +   T   SP    E    S  S S P S
Sbjct: 365  APTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPS 424

Query: 1083 DLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPE 1142
                ++   A  S E     S KP P+    +++         R   R         TP 
Sbjct: 425  PQPTKVSRHASSSPE-----SPKPAPAPGSHREIS-SSPTSKNRSHGRAKRDKSHSHTPS 478

Query: 1143 RKSGQEKSHSV----NTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKD 1198
            R+ G+ +S +      +  +      H++S   Q  +SR  Q+     +   +  S    
Sbjct: 479  RRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQ 538

Query: 1199 VDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERT 1258
               + R       G+           S ++   H        R R+   +R+    S   
Sbjct: 539  RPGWSRSRNTQRRGR---------SRSARRGRSHSRSPATRGRSRSRTPARRGRSRSR-- 587

Query: 1259 GGSPSVRHGSFHEDEDPIGSPRLLSVKG--SPKVDEKVLPYSNITVREESLKFNPYDSSR 1316
              +P+ R              R  + +G    +   +    +   VR  S   +P   S 
Sbjct: 588  --TPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSG 645

Query: 1317 REQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPG 1376
            R +    A+   S   S     R  S+ +  A R   S   +  +R   R R+ R    G
Sbjct: 646  RSRSRTPARRGRS--RSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPR---RG 700

Query: 1377 EVPSDS-DEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFA 1435
               S S    G   S +P+      SS      R  + +  +R  R +SS E  K     
Sbjct: 701  RSRSRSLVRRGRSHSRTPQRRGRSGSSS----ERKNKSRTSQRRSRSNSSPEMKK----- 751

Query: 1436 LDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYM 1495
                    ++    R++SLSS R +  S L    R  +  +   K+K  + PR   S   
Sbjct: 752  --------SRISSRRSRSLSSPRSKAKSRLSL-RRSLSGSSPCPKQKSQTPPRRSRSGSS 802

Query: 1496 K-KKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSD 1554
            + K K RT             K++ +       SR  HSS       +     R+     
Sbjct: 803  QPKAKSRTPPRRSRSSSSPPPKQKSKT-----PSRQSHSSSSPHPKVKSGTPPRQ----- 852

Query: 1555 FISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMEL-TRMQQKEKEKDQKPKEVEKQEDT 1613
                   G  TS  AN  + + Q       S   EL +R   +       P  V+     
Sbjct: 853  -------GSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPP 905

Query: 1614 ENHPKTPESAPENKDSELKTP-----PSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLV 1668
               P +  S+P+ K   + +P          PS + VT  + P      +    VE+ L+
Sbjct: 906  RQSP-SRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLL 964

Query: 1669 TEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQP 1728
                    ++   + KP + P                               +  SG   
Sbjct: 965  PRYSHSGSSSPDTKVKPETPP------------------------------RQSHSGSIS 994

Query: 1729 PYLDAKPPT-PGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDA 1787
            PY   K  T PG S S ++S                        P+ +  D+   + P +
Sbjct: 995  PYPKVKAQTPPGPSLSGSKSPC----------------------PQEKSKDSLVQSCPGS 1032

Query: 1788 NQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKP-VTRKSER 1846
                     S PP      V         + +   RS T       S  E P +  KS+ 
Sbjct: 1033 LSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQT 1092

Query: 1847 IDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRS 1906
              +    RS+SP  E      ++ +  + + +    S    E         ++R ++  S
Sbjct: 1093 SPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPE---------QSRFQSDSS 1143

Query: 1907 VYATMGDHENRSPVKEPVEQPRVTRKRLE-RELQEAAAVPTTPRRGRPPKTRRRADEEEE 1965
             Y T+  +              + + RLE  E +E  A+P  P+        R+ D+   
Sbjct: 1144 SYPTVDSNS------------LLGQSRLETAESKEKMALP--PQEDATASPPRQKDKFSP 1189

Query: 1966 NEAKE-PAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVK 2024
               ++ P  +L   +  R+P  +++ AG  P+ K+ +N     +++ E   E      V 
Sbjct: 1190 FPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKE-QNSALPTSSQDEELME------VV 1242

Query: 2025 ESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSR 2084
            E S EP        S + ++   +  + +P        VE++PA                
Sbjct: 1243 EKSEEPAGQILSHLSSELKEMSTSNFESSPE-------VEERPAVS-------------- 1281

Query: 2085 LAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKED------------- 2131
            L +D+S S  +++A   P  A++  G   S       E S SP +E+             
Sbjct: 1282 LTLDQSQSQASLEAVEVPSMASSWGGPHFS---PEHKELSNSPLRENSFGSPLEFRNSGP 1338

Query: 2132 -------GLSSQLKSD---------PVDPDKEPEKEDVSASGP-----SPEATQLAKQME 2170
                   G SS++K D           DP  + +++   +SG      SP+A + A  M 
Sbjct: 1339 LGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKA-GMS 1397

Query: 2171 LEQAVEHIAKLAEASASAAYKADAPEGLAPEDRD-KPAHQASETELAAAIGSIINDISGE 2229
              Q++   + + +A      +  +    +PE +D  P   +  +   ++ G  + D SG 
Sbjct: 1398 SNQSIS--SPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPG--LRDGSGT 1453

Query: 2230 PENFPAPPPYPG-------------ESQTDLQPPAGAQALQPSEEGMETDEAVSGILETE 2276
            P         PG             E  +  +P A  Q  +P      + E  +  L  +
Sbjct: 1454 PSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQ 1513

Query: 2277 AATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTT 2336
                 S   V+    +  P   +   G+S E     P A   +  E       K + +T 
Sbjct: 1514 RERSGSESSVDQKTVARTPLGQRSRSGSSQELDVK-PSASPQERSESDSSPDSKAKTRTP 1572

Query: 2337 RSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPP- 2395
              +R R+ +   V   +S +       G SP   +      P A      S +P +  P 
Sbjct: 1573 LRQRSRSGSSPEV-DSKSRLSPRRSRSGSSPEVKDKPRAA-PRAQSGSDSSPEPKAPAPR 1630

Query: 2396 ------QSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFR 2449
                  +S +S   + PS E SS   S  E  P   +        P+P      P  R  
Sbjct: 1631 ALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRS 1690

Query: 2450 VHSIIESDPVTPPSDPSIPIPTLPSVTAA-----KLSPPVASGGIPHQSPPTKVTEWITR 2504
              S  E       S  S    + P   +      + SP V+S   P  +  ++ +     
Sbjct: 1691 SRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSS---PEPAEKSRSSRRRRS 1747

Query: 2505 QEEPRAQSTPSPALPPDTKASDVDTSSSTLRK 2536
               PR ++T      P  K   +  S S  R+
Sbjct: 1748 ASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRR 1779



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 172/910 (18%), Positives = 281/910 (30%), Gaps = 121/910 (13%)

Query: 1746 ESNVDPEPDSTQPLSKPA----QKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPA 1801
            E +V+P      P  +PA     +  E NE K E+  A           +   P+ +   
Sbjct: 100  EKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRARE 159

Query: 1802 SEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGE 1861
            ++    +PP      + + S RS TP Q            +K ++ DR +   S+SPR E
Sbjct: 160  AKQPAPEPPKPYSLVRESSSSRSPTPKQK-----------KKKKKKDRGRRSESSSPRRE 208

Query: 1862 AQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVK 1921
             +K  + K       R+ S++       P P        ++  RS   T      R+   
Sbjct: 209  RKKSSKKKKH-----RSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRS 263

Query: 1922 EPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGW 1981
               +    +     R    AA   TT   GR P        E +    EP  T       
Sbjct: 264  TSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTT-----ST 318

Query: 1982 RSPRSQKTAAG--GGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGS 2039
            + P S +TA      P   K K++ +  ATRP  + E                       
Sbjct: 319  QRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPE----------------------- 355

Query: 2040 EQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAA 2099
                    + T   PP            AP      + G S         S    N  + 
Sbjct: 356  -------RSSTGPEPP------------APTPLLAERHGGSPQPLATTPLSQEPVNPPSE 396

Query: 2100 VSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEP---EKEDVSAS 2156
             SP    +     E    + S E S    +   +S    S P  P   P      ++S+S
Sbjct: 397  ASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSS 456

Query: 2157 GPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELA 2216
              S   +    + +   +     ++  + + A  K        P  R     ++ +   +
Sbjct: 457  PTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRS 516

Query: 2217 AAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETE 2276
             +        S +       P  PG S++      G               A  G   + 
Sbjct: 517  RSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSR 576

Query: 2277 AATESSRPPVNAPDPSAGPTDTKEARGNSSET------SHSVPEAKGSKEVEVTLVRKDK 2330
                  R     P      + T   R + S T      S S   A+        + R+ +
Sbjct: 577  TPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSR 636

Query: 2331 GRQKTTRSRRKRNTNKKVVAPVESHVP-ESNQAQGESPAANEGTTVQHPEAPQEEKQSEK 2389
             R    RS R R+          S  P    +++  +PA   G +     A +   +S  
Sbjct: 637  SRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRT 696

Query: 2390 PHSTPPQSCT-----SDLSKIP---STENSSQEISVEERTPTKASVPPDLPPPPQPAPVD 2441
            P     +S +        S+ P       SS E   + RT  + S     P         
Sbjct: 697  PRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSP--------- 747

Query: 2442 EEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQS------PP 2495
                 + R+ S       +P S     +    S++ +   P   S   P +S      P 
Sbjct: 748  --EMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPK 805

Query: 2496 TKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVT 2555
             K     T     R+ S+P P     T +    +SSS        PK  S T     S+T
Sbjct: 806  AKSR---TPPRRSRSSSSPPPKQKSKTPSRQSHSSSSP------HPKVKSGTPPRQGSIT 856

Query: 2556 TAIAEPVSAAP----CLHEAPPPPVDSKKPLEE----KTAPPVTNNSEIQASEVLVAADK 2607
            +  A   S  P    C   +P P + S+ P        + P V +++  + S    ++ +
Sbjct: 857  SPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQ 916

Query: 2608 EKVAPVIAPK 2617
             KV  +I+P+
Sbjct: 917  PKVKAIISPR 926



 Score = 53.1 bits (126), Expect = 5e-06
 Identities = 34/67 (50%), Positives = 42/67 (62%), Gaps = 1/67 (1%)

Query: 254  SPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSA 313
            +P +   ++S  + S S S S S SSSS S SSSSS+SS SS SSSSSS  SPA+     
Sbjct: 2599 TPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP-GPQ 2657

Query: 314  AVPAPTS 320
            A+P P S
Sbjct: 2658 ALPKPAS 2664



 Score = 52.8 bits (125), Expect = 6e-06
 Identities = 37/99 (37%), Positives = 45/99 (45%)

Query: 233  PERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSS 292
            P     HS    P +S    Q     A Q ++  RS S S S S SSSS S SSSSS+SS
Sbjct: 2497 PAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSS 2556

Query: 293  DSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEP 331
             SS S S  S       V    VP+PT     ++ +  P
Sbjct: 2557 GSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRP 2595



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 308/1661 (18%), Positives = 556/1661 (33%), Gaps = 227/1661 (13%)

Query: 682  DYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIER--SQSPVHLRRPQ---S 736
            D+R+D    ++R+ S+ +    + + +      R     P+    S+SP+   R +   S
Sbjct: 1066 DHRSDTSSPEVRQ-SHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSAS 1124

Query: 737  P----GASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKTD 792
            P    G SP Q+ R  SDS       S+   G     +    EK+     E  T +    
Sbjct: 1125 PMLKSGMSPEQS-RFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQ 1183

Query: 793  KERTFDPERVER--ERRLIRKEKVEKDKTDKQKRKGKVHSPSSQ--------SSETDQEN 842
            K++ F P  V+   E  L+ K+ +   +T  ++R G   SP ++        SS+ ++  
Sbjct: 1184 KDK-FSPFPVQDRPESSLVFKDTL---RTPPRERSGAGSSPETKEQNSALPTSSQDEELM 1239

Query: 843  EREQSPEKPRS--CNKLS---REKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVE 897
            E  +  E+P     + LS   +E +     +   +E  P V LT  + +    ++   V 
Sbjct: 1240 EVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVP 1299

Query: 898  KLKA------------KLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKV----PK 941
             + +            +L N  ++ ++    L+   + P  ++++   S  +K     P 
Sbjct: 1300 SMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPF 1359

Query: 942  EKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPE 1001
               L +   +  KE   ++  H   E   D V    +   ++      D+  +   ++  
Sbjct: 1360 LNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERS 1419

Query: 1002 VKKSSPEMEDA-------RVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKL 1054
               SSPEM+D        R  S   P +        R   +   P  K+I +  S+    
Sbjct: 1420 SSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSR--GR 1477

Query: 1055 DRLNTVASPKDCQELASISVGSGSRPSSD---LQARLGELAGESVENQEVQSKKPIPSKP 1111
               ++   PK   +       S S P  +   L  +      ES  +Q+  ++ P+  + 
Sbjct: 1478 SECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRS 1537

Query: 1112 QLKQLQVLDDQGPEREDVRKNYCSLRD-----ETPER-KSGQEKSHSVNTEEKIGIDIDH 1165
            +    Q LD +       R    S  D      TP R +S    S  V+++ ++      
Sbjct: 1538 RSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR 1597

Query: 1166 TQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPS 1225
            + S  +  ++ R   + +     S +  +P         RS     G+ P      S  S
Sbjct: 1598 SGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTES 1657

Query: 1226 KKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSPSVRHGSFHEDE---DPIGSPRLL 1282
              +            + R  R   + S + +    +P  R  S    E       S R  
Sbjct: 1658 SPEH---------PPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSR 1708

Query: 1283 SVKGSPKVDEKVLP----YSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDE-- 1336
            S   SP+   +  P      +++  E + K     SSRR + A   + K +         
Sbjct: 1709 SASSSPETRSRTPPRHRRSPSVSSPEPAEKSR---SSRRRRSASSPRTKTTSRRGRSPSP 1765

Query: 1337 ----LNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHS 1392
                L R  S+ +++  R       S   + + R+R  R      V         + S S
Sbjct: 1766 KPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQ-RSRSRSRVTRRRRGGSGYHSRS 1824

Query: 1393 PRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTITPDTKALLERAK 1452
            P   A  ESSR S     R  + R R    S    R++       ++ +  + A   R++
Sbjct: 1825 P---ARQESSRTS----SRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSR 1877

Query: 1453 S---LSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPI---------PSWYMKKKKI 1500
            S   L S R           R +  R +  + +  S   P+         P    ++ + 
Sbjct: 1878 SRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRS 1937

Query: 1501 RTDSEGKMDDKKEDHKEEEQERQEL-----FASRFLHSSIFEQDSK-RLQHLERKEEDS- 1553
            RT +  +    +       + R          SR   S I  + S+ R   + R+   S 
Sbjct: 1938 RTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSR 1997

Query: 1554 -DFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQED 1612
               ++ R    +TS      + S   P +   SR    T +  +++ + + P  + ++  
Sbjct: 1998 TSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSR--SRTPLLPRKRSRSRSPLAIRRR-- 2053

Query: 1613 TENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEK 1672
              +  +TP +A   K S  ++PP++   S +  + + + SA    T + +      T   
Sbjct: 2054 --SRSRTPRTA-RGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSR---TPPV 2107

Query: 1673 TVEPATVSEEAKPASEPAP-----------------APVEQLEQ-----VDLPPGADPDK 1710
             +  + +S  ++P+  P P                  P+  L+Q     +D P    PD 
Sbjct: 2108 ALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDH 2167

Query: 1711 EAAMMPAGVEEG---------SSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSK 1761
            +   +P    +          S G   P          A  SQ  + V      T P + 
Sbjct: 2168 QRTSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAAN 2227

Query: 1762 PAQKSEEANEPKAEKPDATADAEPD----ANQKAEAAPESQPPASEDLEVDPPVA--AKD 1815
             A +   A+        A   A P     A+ +  AA  +   AS    V P     A  
Sbjct: 2228 LASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADP 2287

Query: 1816 KKPN----KSKRSKTPVQAAAVSIV---------------EKPVTRKSERIDREKLKRSN 1856
            + P         ++TP   AA+S+                  P    S  +   +   + 
Sbjct: 2288 RTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHAT 2347

Query: 1857 SPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHEN 1916
            +P   A       +    +T      + +      P +PLS   R + R+    +    +
Sbjct: 2348 APVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARS 2407

Query: 1917 RSPVKEPVEQPRVTRKRLERELQEAAAVPT----TPRRGRPPKTRRRADEEEENEAKEPA 1972
            R+P   P  Q R+T +R           P+     P + +P   R        ++++   
Sbjct: 2408 RTPPSAP-SQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQP---RSPVPSAFSDQSRCLI 2463

Query: 1973 ETLKPPEGWRSPRSQKTA----------------AGGGPQGKKGKNEPKVDATRPEATTE 2016
                P  G +S  S   A                A G P    G+      A +P A   
Sbjct: 2464 AQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAA 2523

Query: 2017 VGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKN----------PPETAPVEVVEKK 2066
            + P    + SS    ++   + S        +    +           PE A   V    
Sbjct: 2524 LQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPT 2583

Query: 2067 PAPEKNSKSKR-------GRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAV 2119
            PAP++  +  R        R R S  +   S+S  +  ++ S   +++ +    S   + 
Sbjct: 2584 PAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2643

Query: 2120 SPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSP 2160
            S   S SP K      Q    P  P K P  E  S S   P
Sbjct: 2644 SSSSSPSPAKP---GPQALPKPASPKKPPPGERRSRSPRKP 2681



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 123/610 (20%), Positives = 204/610 (33%), Gaps = 98/610 (16%)

Query: 2935 GINTPPVLVHNQLVLT---PSIVTT------NKKLADPV-TLKIETKVLQPANLGSTLTP 2984
            G  TPPV +++  +     PS+  T      +  + +P+ + +    VLQ A  G ++  
Sbjct: 2101 GSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQA--GGSMMD 2158

Query: 2985 HHPPALPSKLPTEV--NHVPS-------GPSIPADRTVSHLAAAKLDAHSPRPSGPGPSS 3035
               P +P    T V  NH  S         S+   R    ++AA L A   +   P P  
Sbjct: 2159 GPGPRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLM 2218

Query: 3036 FPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIH------PEQSVIMPPHSITQTVS 3089
              R +  ++ AS   + +A  M  A    P   ++++      P  +  M   S    V+
Sbjct: 2219 SLRTAPAANLASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVA 2278

Query: 3090 LSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRA----------PQRAST 3139
             S ++  + R  TPT P++        L   R P     + +            P  + T
Sbjct: 2279 PSAVNLADPR--TPTAPAVN-------LAGARTPAALAALSLTGSGTPPTAANYPSSSRT 2329

Query: 3140 PQ-PAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIM 3198
            PQ PA A +    S H            A A AP       M         T PR V + 
Sbjct: 2330 PQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPR-VPLS 2388

Query: 3199 VHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLP- 3257
             +  V+  +  P       + PP++ +  +   E A +P ++    P+ + +P     P 
Sbjct: 2389 AYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPR 2448

Query: 3258 APAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPP 3317
            +P P+   +     +           T PV    G Q + S          GD       
Sbjct: 2449 SPVPSAFSDQSRCLIAQ---------TTPVA---GSQSLSSGAVATTTSSAGD------- 2489

Query: 3318 AQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQP 3377
                H    +  + G+P     +  G PP     Q P  + + QPA+       S     
Sbjct: 2490 ----HNGMLSVPAPGVPH----SDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSS 2541

Query: 3378 GQPPSSKMPQVSQEAKGTQTGVEQPRLPAGP-------------------ANRPPEPHTQ 3418
                SS     S  +  + +  E   LP  P                     RPPEP   
Sbjct: 2542 SSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPA 2601

Query: 3419 VQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEF 3478
             ++ ++ +  +S  S  S S       S  + ++        ++S  S+ P    P  + 
Sbjct: 2602 KRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS---SSSSSSSSSPSPAKPGPQA 2658

Query: 3479 QPAPKQDSSP 3488
             P P     P
Sbjct: 2659 LPKPASPKKP 2668



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 38/96 (39%), Positives = 50/96 (52%), Gaps = 7/96 (7%)

Query: 245  PHSSQSRNQSPQRLASQASRPTRSPSGSGSR------SRSSSSDSISSSSSTSSDSSDSS 298
            P  +  R  SP     +A R  R P  + ++      S SSSS S SSSSS+SS SS SS
Sbjct: 2572 PEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSS 2631

Query: 299  SSSSDDSPARSVQSAAVPAPTSQLLSSLEKD-EPRK 333
            SSSS  S + S  S++ P+P      +L K   P+K
Sbjct: 2632 SSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKK 2667



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 64/234 (27%), Positives = 82/234 (35%), Gaps = 24/234 (10%)

Query: 82  GTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPPSLHAREGRYERRLDGASDNRE 141
           G   SA RG   + S A+R R  S      G      P    +R     RR       R 
Sbjct: 552 GRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRR-------RS 604

Query: 142 RAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDAHDPRY 201
           R+   +  G     T    R+R       R P  R         SRSRSP R        
Sbjct: 605 RSRTPARRGRSRSRTPARRRSRT------RSPVRRR--------SRSRSPARRSGRSRSR 650

Query: 202 EP--RAREQFTLPSVVHRDIYRDDITREVRGR-RPERNYQHSRSRSPHSSQSRNQSPQRL 258
            P  R R +   P+   R   R    R  R R R       SRSR+P   +SR++S  R 
Sbjct: 651 TPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRR 710

Query: 259 ASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQS 312
               SR  +    SGS S   +    S   S S+ S +   S      +RS+ S
Sbjct: 711 GRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSS 764



 Score = 41.2 bits (95), Expect = 0.019
 Identities = 28/111 (25%), Positives = 52/111 (46%), Gaps = 13/111 (11%)

Query: 765 SCSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKR 824
           S SS SP   +K          K +K D+ R  +     RER+   K+K  + +++ +KR
Sbjct: 177 SSSSRSPTPKQK---------KKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKR 227

Query: 825 KGKVHSPSSQSSETDQENEREQS----PEKPRSCNKLSREKADKEGIAKNR 871
           K +  +P S+    D++ +R +S    P+  R+    S + A     +++R
Sbjct: 228 KHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSR 278



 Score = 41.2 bits (95), Expect = 0.019
 Identities = 47/172 (27%), Positives = 67/172 (38%), Gaps = 33/172 (19%)

Query: 186 SRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHSRSRSP 245
           SRSR+P R  +       R R +   P+   R   R  + R  R R P R    SRSR+P
Sbjct: 594 SRSRTPTRRRSRSRTPARRGRSRSRTPAR-RRSRTRSPVRRRSRSRSPARRSGRSRSRTP 652

Query: 246 ------------------------HSSQSRNQSPQRLASQASR-PTRSPSGSGSRSRSSS 280
                                    S +SR+++P R     SR P R  S S S  R   
Sbjct: 653 ARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGR 712

Query: 281 SDSI-------SSSSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSS 325
           S S        S SSS   + S +S   S  + +  ++ + + +  S+ LSS
Sbjct: 713 SHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSS 764



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 33/144 (22%), Positives = 54/144 (37%), Gaps = 9/144 (6%)

Query: 187 RSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHSRSRSPH 246
           + RSP        + + R R + T P+   R  +R             R+   S +   H
Sbjct: 228 KHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTH 287

Query: 247 SSQSRNQSPQRLA---SQASRPTRSPSGSGSRSRSSSSDSISSSSST-----SSDSSDSS 298
           ++    +SP   +    +   P   P G+ S  R SS ++ +   S+       D  + S
Sbjct: 288 TTALAGRSPSPASGRRGEGDAPFSEP-GTTSTQRPSSPETATKQPSSPYEDKDKDKKEKS 346

Query: 299 SSSSDDSPARSVQSAAVPAPTSQL 322
           ++    SP RS      PAPT  L
Sbjct: 347 ATRPSPSPERSSTGPEPPAPTPLL 370



 Score = 38.1 bits (87), Expect = 0.16
 Identities = 41/153 (26%), Positives = 56/153 (36%), Gaps = 22/153 (14%)

Query: 184 YASRSRSPNRFDAHDPRY----EPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNY-- 237
           ++S S  P       PR      P+A EQ   P    R  +      E++ R P R+   
Sbjct: 835 HSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQ--RRSCFESSPDPELKSRTPSRHSCS 892

Query: 238 -----QHSRSRSPHSSQSRNQSPQ---------RLASQASRPTRSPSGSGSRSRSSSSDS 283
                +   S  P  S SR+ SPQ         R  S +   + SPS   SR+    S S
Sbjct: 893 GSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRS 952

Query: 284 ISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVP 316
           +S  S+  S      S S   SP   V+    P
Sbjct: 953 VSPCSNVESRLLPRYSHSGSSSPDTKVKPETPP 985



 Score = 37.7 bits (86), Expect = 0.21
 Identities = 37/127 (29%), Positives = 49/127 (38%), Gaps = 40/127 (31%)

Query: 247  SSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISS-------------------- 286
            + + R+ S    +S +S  + S S S S S SSSSDS  S                    
Sbjct: 2527 AKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAP 2586

Query: 287  --------------------SSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSSL 326
                                SSS+SS SS SSSSSS  S + S  S++  + +S   SS 
Sbjct: 2587 KEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2646

Query: 327  EKDEPRK 333
                P K
Sbjct: 2647 SSPSPAK 2653



 Score = 37.4 bits (85), Expect = 0.28
 Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 8/99 (8%)

Query: 229 RGRR-----PERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDS 283
           RGRR     P R  + S  +  H S+S  +S +R     +  ++  S    R RS S+  
Sbjct: 196 RGRRSESSSPRRERKKSSKKKKHRSES--ESKKRKHRSPTPKSKRKSKDKKRKRSRSTTP 253

Query: 284 ISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQL 322
              S      +S  S+SSSD S +RS +SAA    T+ L
Sbjct: 254 APKSRRAHRSTSADSASSSDTSRSRS-RSAAAKTHTTAL 291



 Score = 37.0 bits (84), Expect = 0.36
 Identities = 37/169 (21%), Positives = 62/169 (36%), Gaps = 12/169 (7%)

Query: 3326 PAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKM 3385
            P  +S   PS  +TA + P    E     +  +S     P+P     +    G  P +  
Sbjct: 313  PGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSP-----ERSSTGPEPPAPT 367

Query: 3386 PQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPV 3445
            P +++   G+   +    L   P N P E      R+  ++ P   P   S    P  P 
Sbjct: 368  PLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKS-PEKLPQSSSSESSP--PS 424

Query: 3446 SLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQR 3494
              PT+ + +     P +  P+  PG    H E   +P   +  H  ++R
Sbjct: 425  PQPTKVS-RHASSSPESPKPAPAPG---SHREISSSPTSKNRSHGRAKR 469



 Score = 36.6 bits (83), Expect = 0.47
 Identities = 27/77 (35%), Positives = 38/77 (49%), Gaps = 1/77 (1%)

Query: 224  ITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRP-TRSPSGSGSRSRSSSSD 282
            I R  R R P    + SRSRSP + + R++S     ++  R  TRSP     RS S SS 
Sbjct: 2026 IRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSS 2085

Query: 283  SISSSSSTSSDSSDSSS 299
              S S++  +  + S S
Sbjct: 2086 DRSRSATPPATRNHSGS 2102



 Score = 36.2 bits (82), Expect = 0.61
 Identities = 61/234 (26%), Positives = 77/234 (32%), Gaps = 40/234 (17%)

Query: 87  AARGLDDTVSIASRSREVSGFRGGGGGPAYGPPPSLHAREGRYERRLDGASDNRERAYEH 146
           A RG   + + A R R  S       G +    P   AR GR   R      +R R+   
Sbjct: 653 ARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTP---ARRGRSRSRTPRRGRSRSRSLVR 709

Query: 147 SAYGH----HERGTGGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDAHDPRYE 202
               H      RG  G    R          + RT Q       RSRS +  +    R  
Sbjct: 710 RGRSHSRTPQRRGRSGSSSERKN--------KSRTSQR------RSRSNSSPEMKKSRIS 755

Query: 203 PRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQA 262
            R     + P    +   R  + R + G             SP   Q     P+R  S +
Sbjct: 756 SRRSRSLSSPRSKAKS--RLSLRRSLSGS------------SPCPKQKSQTPPRRSRSGS 801

Query: 263 SRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVP 316
           S+P         RSRSSSS      S T S  S SSS     SP   V+S   P
Sbjct: 802 SQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSS-----SPHPKVKSGTPP 850



 Score = 36.2 bits (82), Expect = 0.61
 Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)

Query: 226  REVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSP-SGSGSRSRSSSSDSI 284
            R  R R P    + SRSR+P   + R++S   LA +    +R+P +  G RS + S  +I
Sbjct: 2016 RRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAI 2075

Query: 285  SSSSSTSSDSSDSSSSSS 302
               S++ S SSD S S++
Sbjct: 2076 RRRSASGS-SSDRSRSAT 2092



 Score = 35.8 bits (81), Expect = 0.80
 Identities = 39/169 (23%), Positives = 59/169 (34%), Gaps = 41/169 (24%)

Query: 3222 ASKAPQQPGKEAAKTPDAKAAPTPTPAP------VPVPVPLPAPAPAPHGEARILTVTPS 3275
            A+K P  P ++  K    K+A  P+P+P         P P P  A    G  + L  TP 
Sbjct: 327  ATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPL 386

Query: 3276 NQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPS 3335
            +Q    P+ PP                               A  T  + P  S   LP 
Sbjct: 387  SQ---EPVNPP-----------------------------SEASPTRDRSPPKSPEKLPQ 414

Query: 3336 RTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSK 3384
               ++++  PP  +P +  +   S+ P  P P   P    +    P+SK
Sbjct: 415  --SSSSESSPPSPQPTKVSRHA-SSSPESPKPAPAPGSHREISSSPTSK 460



 Score = 35.8 bits (81), Expect = 0.80
 Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 10/93 (10%)

Query: 226 REVRGRRPERNYQH---------SRSRSP-HSSQSRNQSPQRLASQASRPTRSPSGSGSR 275
           R  R R   R   H         SRSR+P    +SR+++P R  S++  PTR  S S + 
Sbjct: 550 RRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTP 609

Query: 276 SRSSSSDSISSSSSTSSDSSDSSSSSSDDSPAR 308
           +R   S S + +   S   S     S   SPAR
Sbjct: 610 ARRGRSRSRTPARRRSRTRSPVRRRSRSRSPAR 642



 Score = 35.8 bits (81), Expect = 0.80
 Identities = 43/152 (28%), Positives = 65/152 (42%), Gaps = 21/152 (13%)

Query: 173  PRERTLQHGLYYA----SRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREV 228
            P+ RT + G   +    ++SR+P R      R   R+  + T  + + R       + E 
Sbjct: 1663 PKSRTARRGSRSSPEPKTKSRTPPR------RRSSRSSPELTRKARLSRRSRSASSSPET 1716

Query: 229  RGRRPERNYQHSRSRSPH-SSQSRNQSPQRLASQ-----ASRPTRSPSG-----SGSRSR 277
            R R P R+ +     SP  + +SR+   +R AS       SR  RSPS        SRSR
Sbjct: 1717 RSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSR 1776

Query: 278  SSSSDSISSSSSTSSDSSDSSSSSSDDSPARS 309
            S    + ++     S SS S+S     S +RS
Sbjct: 1777 SRREKTRTTRRRDRSGSSQSTSRRRQRSRSRS 1808



 Score = 35.8 bits (81), Expect = 0.80
 Identities = 57/226 (25%), Positives = 91/226 (40%), Gaps = 19/226 (8%)

Query: 99   SRSREVSGFRGGGGGPAYGPPPSLHAREGRYERRLDGASD--NRERAYEHSAYGHHERGT 156
            SRSR     RGG G  +  P     +R     RR    +   +R+R+   ++    +R  
Sbjct: 1806 SRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSR 1865

Query: 157  GGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDAHDPRYEPRAREQFTLPSVVH 216
                   H      R  R RT        SR RS +R     P    R+R + ++     
Sbjct: 1866 SRASPATH------RRSRSRTP-----LISRRRSRSRTS---PVSRRRSRSRTSVTRRRS 1911

Query: 217  RDIYRDDITREVRGRRPERNYQHSRSRSPHSSQ-SRNQSPQRLASQASRPTRSPSGSGSR 275
            R        R  R R P    + SRSR+P + + SR+++P  +  + SR +R+P  +  R
Sbjct: 1912 RSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPP-VTRRRSR-SRTPPVTRRR 1969

Query: 276  SRSSSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQ 321
            SRS +S      S + +       S S  SP    +S +  +P ++
Sbjct: 1970 SRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTR 2015



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 52/263 (19%), Positives = 89/263 (33%), Gaps = 82/263 (31%)

Query: 3027 RPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQ 3086
            R + P P S  R +H S++A +A S++ +   +         +++             + 
Sbjct: 249  RSTTPAPKS--RRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGR----------SP 296

Query: 3087 TVSLSHLSQGEVRMNTPTLPSITYSIRPE-ALHSPRAPLQPQQIEVR---------APQR 3136
            + +     +G+   + P   S      PE A   P +P + +  + +         +P+R
Sbjct: 297  SPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPER 356

Query: 3137 ASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVR 3196
            +ST    PA  P LA +H          P   AT P+  E +                  
Sbjct: 357  SSTGPEPPAPTPLLAERHGGS-------PQPLATTPLSQEPVN----------------- 392

Query: 3197 IMVHPHVTAVSEQPRAADGVVKVPPASKAP---QQPGKEAAKTPDAKAAPTPTPAPVPVP 3253
                                   PP+  +P   + P K   K P + ++ +  P+P P  
Sbjct: 393  -----------------------PPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTK 429

Query: 3254 V----------PLPAPAPAPHGE 3266
            V          P PAPAP  H E
Sbjct: 430  VSRHASSSPESPKPAPAPGSHRE 452



 Score = 34.7 bits (78), Expect = 1.8
 Identities = 37/114 (32%), Positives = 48/114 (42%), Gaps = 22/114 (19%)

Query: 241  RSRSPHSSQSRNQ--SPQRLASQASRPT------RSPSGSGSRSRSSSSDSISSSSS--- 289
            RSRSP S +  N+  +PQR  S +          R+P G  SRS SS    +  S+S   
Sbjct: 1496 RSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQE 1555

Query: 290  -TSSDSSDSSS----------SSSDDSPARSVQSAAVPAPTSQLLSSLEKDEPR 332
             + SDSS  S           S S  SP    +S   P  +    S   KD+PR
Sbjct: 1556 RSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPR 1609



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 24/68 (35%), Positives = 29/68 (42%)

Query: 241  RSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSS 300
            RSRS  SS+ R  SP+  +S  S P   P    +R  S SS    + S T      S SS
Sbjct: 1635 RSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSS 1694

Query: 301  SSDDSPAR 308
                  AR
Sbjct: 1695 PELTRKAR 1702



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 45/185 (24%), Positives = 72/185 (38%), Gaps = 14/185 (7%)

Query: 137  SDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDA 196
            S +R R  +       +R       +R   +   R    R  + G  Y   SRSP R ++
Sbjct: 1773 SRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGY--HSRSPARQES 1830

Query: 197  HDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQ 256
                   R     T P+   R           R R     ++ SRSR+  ++  R++S  
Sbjct: 1831 SRTSSRRRRGRSRTPPTSRKRS----------RSRTSPAPWKRSRSRASPATHRRSRSRT 1880

Query: 257  RLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVP 316
             L S+  R +RS +   SR RS S  S++   S S  S  S   S   +P  + + +   
Sbjct: 1881 PLISR--RRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSR 1938

Query: 317  APTSQ 321
             PT++
Sbjct: 1939 TPTTR 1943



 Score = 32.7 bits (73), Expect = 6.8
 Identities = 25/117 (21%), Positives = 51/117 (43%), Gaps = 5/117 (4%)

Query: 220 YRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGS----- 274
           +R +   + R  R        +S+     +SR+ +P   + +A R T + S S S     
Sbjct: 218 HRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRS 277

Query: 275 RSRSSSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEP 331
           RSRS+++ + +++ +  S S  S      D+P     + +   P+S   ++ +   P
Sbjct: 278 RSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSP 334



 Score = 32.7 bits (73), Expect = 6.8
 Identities = 30/93 (32%), Positives = 43/93 (46%), Gaps = 2/93 (2%)

Query: 226  REVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSIS 285
            R  R R      + SRSR+P + + R++S   L  +    +RSP     RSRS +  +  
Sbjct: 2004 RRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTAR 2063

Query: 286  SSSS-TSSDSSDSSSSSSDDSPARSVQSAAVPA 317
               S T S  +    S+S  S  RS +SA  PA
Sbjct: 2064 GKRSLTRSPPAIRRRSASGSSSDRS-RSATPPA 2095



 Score = 32.7 bits (73), Expect = 6.8
 Identities = 47/215 (21%), Positives = 78/215 (36%), Gaps = 23/215 (10%)

Query: 734  PQSPGAS-PSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKTD 792
            P S GA  PS    L    ERR  S SS  S S SS S         S     + +  +D
Sbjct: 2510 PASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSS-------SSSSSSSSSGSSSSD 2562

Query: 793  KERTFDPERVE-----------RERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQE 841
             E +  P + E             +  +R+ +  +    K+KR+    S SS SS +   
Sbjct: 2563 SEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSS 2622

Query: 842  NEREQSPEKPRSCNKLSREKADKEGI---AKNRLELMPCVVLTRVKEKEGKVIDHTPVEK 898
            +    S     S +  S   +        AK   + +P     + K   G+    +P + 
Sbjct: 2623 SSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPK-KPPPGERRSRSPRKP 2681

Query: 899  LKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLE 933
            + +  D+ ++  S ++++    Q  P     S  E
Sbjct: 2682 IDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSE 2716



 Score = 32.3 bits (72), Expect = 8.9
 Identities = 97/446 (21%), Positives = 153/446 (34%), Gaps = 43/446 (9%)

Query: 2823 KTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVAT 2882
            K+  P R S   S  PP        +QS S S   P  V +  PP +G    +  AN  +
Sbjct: 807  KSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHP-KVKSGTPPRQG-SITSPQANEQS 864

Query: 2883 HSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVL 2942
             +    +    +  P + S    R S     P  +  STP  Q  +     Q      ++
Sbjct: 865  VTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQP-KVKAII 923

Query: 2943 VHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVP 3002
               Q   + S   +  ++    T +    V   +N+ S L P +  +  S   T+V    
Sbjct: 924  SPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVK--- 980

Query: 3003 SGPSIPADRTVSHLAAAKLDAHSPRPSGPGPS-SFPRASHPSSTASTALSTNATVMLAAG 3061
              P  P  ++ S   +      +  P GP  S S        S  S   S   ++ L AG
Sbjct: 981  --PETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAG 1038

Query: 3062 IPVPQFISSIHPEQSVI------MPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIR-- 3113
            +      SS  P +S        +   S T     S  S  EVR +    PS+    +  
Sbjct: 1039 VK-----SSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTS 1093

Query: 3114 PEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPV 3173
            P+   S R+     ++  R+P R    + + +  P L S   PE+        +  T  V
Sbjct: 1094 PKGGRS-RSSSPVTELASRSPIRQDRGEFSAS--PMLKSGMSPEQSRFQSDSSSYPT--V 1148

Query: 3174 QSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVP----PAS------ 3223
             S  L+ QS       T     ++ + P   A +  PR  D     P    P S      
Sbjct: 1149 DSNSLLGQSRLE----TAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKD 1204

Query: 3224 --KAPQQPGKEAAKTPDAKAAPTPTP 3247
              + P +    A  +P+ K   +  P
Sbjct: 1205 TLRTPPRERSGAGSSPETKEQNSALP 1230



 Score = 32.3 bits (72), Expect = 8.9
 Identities = 36/123 (29%), Positives = 54/123 (43%), Gaps = 14/123 (11%)

Query: 227  EVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISS 286
            +++G+        S + SP   QS ++SP    S  S+   SP G  SRS SS    ++S
Sbjct: 1056 QLKGQSQTSPDHRSDTSSPEVRQSHSESP----SLQSKSQTSPKGGRSRS-SSPVTELAS 1110

Query: 287  SSSTSSDSSDSSSS---SSDDSPARS---VQSAAVPAPTSQLL---SSLEKDEPRKSFGI 337
             S    D  + S+S    S  SP +S     S++ P   S  L   S LE  E ++   +
Sbjct: 1111 RSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMAL 1170

Query: 338  KVQ 340
              Q
Sbjct: 1171 PPQ 1173



 Score = 32.3 bits (72), Expect = 8.9
 Identities = 45/174 (25%), Positives = 67/174 (38%), Gaps = 26/174 (14%)

Query: 137  SDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDA 196
            S  R+R+   S      RG  G+       Q+  R    R          RSR+P     
Sbjct: 1798 SRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRR-------RGRSRTP----- 1845

Query: 197  HDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQS-P 255
              P    R+R + T P+   R           R R     ++ SRSR+P  S+ R++S  
Sbjct: 1846 --PTSRKRSRSR-TSPAPWKRS----------RSRASPATHRRSRSRTPLISRRRSRSRT 1892

Query: 256  QRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDSPARS 309
              ++ + SR   S +   SRSR+S      S S T   +   S S +  +  RS
Sbjct: 1893 SPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRS 1946


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  105 bits (262), Expect = 8e-22
 Identities = 196/1080 (18%), Positives = 428/1080 (39%), Gaps = 122/1080 (11%)

Query: 607  RDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYPARGREFYSEWETYQG 666
            R+  E+  + REE++      QDR           + E+  +++  R      E E  Q 
Sbjct: 213  RELLELRRKGREEKQQQRRERQDR----------VFQEEEEKEWRKRETVLRKEEEKLQ- 261

Query: 667  DYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIERSQ 726
                    ++P+  R+ + +  E+ +R+   ++  RER+ E  E  + R    + + R Q
Sbjct: 262  -------EEEPQRQRELQEE--EEQLRKLERQELRRERQEE--EQQQQRLRREQQLRRKQ 310

Query: 727  SPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYT 786
                 RR Q       Q  R   +  R    R          L   + E+  + +L R  
Sbjct: 311  E--EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368

Query: 787  KNEKTDKERTFD-----PERVERERRLIRKEKVEKD---KTDKQKRKGKVHSPSSQSSET 838
            + E+ +++   +      +++ RE++L R++++ ++   + ++Q R+ +      Q    
Sbjct: 369  EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 428

Query: 839  DQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEK 898
             +E   EQ  E+ R   +L RE+ ++    K   E        R ++ +    +      
Sbjct: 429  QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488

Query: 899  LKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLES---VRMKVPKEKGLSSHVE----- 950
            LK + +    +    +Q+L+  Q E  +  L + E    ++ ++  E+ L    E     
Sbjct: 489  LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548

Query: 951  --VVEKEGRL---KARKHLKPEQP--ADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVK 1003
                E+E RL   +  + LK EQ    D +   + E+ + R +R  +  L+   ++ EV+
Sbjct: 549  LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608

Query: 1004 KSSPEMEDARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASP 1063
            +   E    + L +++P+   R+ +L  E + ER   R++ L+RE ++ +  RL      
Sbjct: 609  RLEQEERREQRLKREEPEEERRQQLLKSEEQEER---RQQQLRREQQERREQRLKREEEE 665

Query: 1064 KDCQELASISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQG 1123
            +  ++          +   + + R  ELA E  E    + K  IP     K    L+ + 
Sbjct: 666  ERLEQRL--------KREHEEERREQELAEEEQEQARERIKSRIP-----KWQWQLESEA 712

Query: 1124 PEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQ--- 1180
              R+   K Y   R +  +R+  +++      E ++    +  +++R+Q E+ +R+    
Sbjct: 713  DARQS--KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ-EEERAHRQQQEEEQRRDFTW 769

Query: 1181 --QMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGK-------PPQDVTDDSPPSKKKRMD 1231
              Q E +  +  +  S +  + E   R L  E  +       P ++  +     +++R  
Sbjct: 770  QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK 829

Query: 1232 HVDF----DICTKRERNYRSSRQ---ISEDSERTGGSPSVRHGSFHEDEDPIGSPRLLSV 1284
             + F    +   +RER  +   +   + ED ER       R   +    +     R  ++
Sbjct: 830  ELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889

Query: 1285 KGSPKVDEKVLPYSN-ITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQ 1343
               P + E++      +   EE L+    +  RR++     + +  +   E++L R + +
Sbjct: 890  YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949

Query: 1344 MKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSR 1403
             ++   R          K   L+++  + L  GE P         K +        E  +
Sbjct: 950  KRRRQER-----ERQYRKDKKLQQKEEQLL--GEEPEKRRRQEREKKYREEEELQQEEEQ 1002

Query: 1404 LSFLLRDREDKLR----ERDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSRE 1459
               LLR+  +K R    ER  R    L++ +      ++    + + L ER +     RE
Sbjct: 1003 ---LLREEREKRRRQEWERQYRKKDELQQEEEQLLREER----EKRRLQERERQY---RE 1052

Query: 1460 ENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEE 1519
            E     + +      R  + +++++         Y K+++++ + E  + ++ E  + +E
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQ-------YRKEEELQQEEEQLLREEPEKRRRQE 1105

Query: 1520 QERQ----ELFASRFLHSSIFEQDSKRLQHLE---RKEEDSDFISGRIYGKQTSEGANST 1572
            +ERQ    E            E++ +R Q LE   R+EE+      ++  ++  +     
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE 1165

Query: 1573 TDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELK 1632
             +              +L R +++EK + ++ ++  ++E+ +   +      E++ S+LK
Sbjct: 1166 LERQYREEEELQQEEEQLLR-EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 200/1109 (18%), Positives = 427/1109 (38%), Gaps = 137/1109 (12%)

Query: 615  ERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYP---------ARGREFYSEWETYQ 665
            E+R  R +   + ++   +   +      E+ RRD+           RGR+  S     +
Sbjct: 737  EKRRRRESELQWQEEERAHRQQQE-----EEQRRDFTWQWQAEEKSERGRQRLSARPPLR 791

Query: 666  GDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIERS 725
             +  E +   + R+ R+ R  P E++  +   ++RERE+E +  E +       R  +  
Sbjct: 792  -EQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850

Query: 726  QSPVHLRRPQSPGASPSQAE------RLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDK 779
            +    L+  Q    S  Q        +L  + +RR ++  +          P   E+L K
Sbjct: 851  EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA---------KPALQEQLRK 901

Query: 780  SRL-----ERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQ 834
             +      E   + E+ +K R  + ER  RE   +++E+ +  + +++KR+ +      +
Sbjct: 902  EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961

Query: 835  SSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVI--- 891
              +  Q+ E +   E+P    +  REK  +E   +  L+     +L   +EK  +     
Sbjct: 962  KDKKLQQKEEQLLGEEPEKRRRQEREKKYRE---EEELQQEEEQLLREEREKRRRQEWER 1018

Query: 892  DHTPVEKLKAK----LDNDTVKSSALDQKLQVSQTEPAKSDLSKL----------ESVRM 937
             +   ++L+ +    L  +  K    +++ Q  + E  + +  +L          + +  
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078

Query: 938  KVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVD------LEKLEARKRRFADS 991
            +  KE+ L    E + +E   K R+  +  Q  +             E+ E R+R+  + 
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138

Query: 992  NLKAEKQ----KPEVKKSSPEMEDARVLSKK---QPDVSSREVILLREGEAERKPVRK-- 1042
              + E++    + ++ +  PE    + L ++   + ++   E  LLRE + +R+  R+  
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198

Query: 1043 ----EILKRESKKIKL---------------DRLNTVASPK------DCQELASISVGS- 1076
                E L+R+ +K +                ++ N V   K      + ++   +     
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL 1258

Query: 1077 -GSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCS 1135
               +   DLQ  LGE      E +  + ++     P+ +QL+  + +  +R D +     
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318

Query: 1136 --LRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFG 1193
              LR+E  E++  QE       EE++  + +     R++ ++  R++++  +  +  KF 
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ-EQGRKFL 1377

Query: 1194 SPKKDV--DEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTK-RERNYRSSRQ 1250
              ++ +   E ER+ L  E     Q+        + ++    +  +  + R+R +R   Q
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437

Query: 1251 ISEDSERTGGS-------PSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVR 1303
                 ER              RH  F E+E  +       +    + D K L        
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER-DRKFLE------E 1490

Query: 1304 EESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRD 1363
            E+ L+    D   REQ     + +   L  E +L+R   Q K       +       +R 
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550

Query: 1364 SLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLS 1423
              R R  R+ E  ++  + +E    +    R   L E      + R  +++    DE+  
Sbjct: 1551 QDRDRKFREEE--QLRQEREEQQLSRQERDRKFRLEEQK----VRRQEQERKFMEDEQQL 1604

Query: 1424 SSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKV 1483
               E  +      D+    D + L ER +     +E +  FL+ + +    R  ++++  
Sbjct: 1605 RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR--RQEREQQLR 1662

Query: 1484 DSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRL 1543
                R     + +++++  + E +   ++E  ++  +E Q+L         + E+   R 
Sbjct: 1663 HDRDRK----FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR 1718

Query: 1544 QHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQK 1603
            Q LERK  + + +      +Q +E            ++       E    Q + +E+D+K
Sbjct: 1719 QELERKFREEEQL------RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772

Query: 1604 PKEVE--KQEDTENHPKTPESAPENKDSE 1630
             +E E  +QE  E   ++ ES  + ++ E
Sbjct: 1773 FREEEQLRQEREEQQLRSQESDRKFREEE 1801



 Score = 84.7 bits (208), Expect = 2e-15
 Identities = 173/1002 (17%), Positives = 400/1002 (39%), Gaps = 106/1002 (10%)

Query: 667  DYYESRYYDDPREYRDYRNDPYEQDIRE---YSYRQRERERERERFESDRDRDHERRPIE 723
            D  ES   D  +E    R +P ++ + E      RQ+ +E+ERE  E +   + + R  +
Sbjct: 104  DGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQ 163

Query: 724  RSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLE 783
            R +     RR +       Q +      ERR             +   P  E+L +  L 
Sbjct: 164  RDRQ----RRDEELW---RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216

Query: 784  RYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQENE 843
               +  + +K++    +R ER+ R+ ++E  E+ +  K++   +      Q  E  ++ E
Sbjct: 217  ELRRKGREEKQQ----QRRERQDRVFQEE--EEKEWRKRETVLRKEEEKLQEEEPQRQRE 270

Query: 844  REQSPEKPRSCNK--LSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKA 901
             ++  E+ R   +  L RE+ ++E   + +  L     L R +E+E +       E+ + 
Sbjct: 271  LQEEEEQLRKLERQELRRERQEEE---QQQQRLRREQQLRRKQEEERR----EQQEERRE 323

Query: 902  KLDNDTVKSSALDQKLQVSQTEPAKSDL---SKLESVRMKVPKEKGLSSHVEVVEKEGRL 958
            + +    +    +Q+L+  Q E  +  L    + E    ++ +E+      + + +E +L
Sbjct: 324  QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383

Query: 959  KARKHLKPEQPADGVSAVDLEKLEARKRRF-ADSNLKAEKQ---KPEVKKSSPEMEDARV 1014
            +  + L+ EQ       +  E+   R+++   +  L+ E+Q   + E ++   + E  R 
Sbjct: 384  RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR 443

Query: 1015 LSKKQPDVSSREVILLREGEAER--KPVRKEILKRESKKIKLDRLNTVASPKDCQELASI 1072
              + + +   R   L RE E ER  +  RK+ LKR+ ++ + +R   +   +  ++    
Sbjct: 444  EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503

Query: 1073 SVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKN 1132
                        + RL     E    Q ++S++ +  + + ++ Q+L  +  +R +  + 
Sbjct: 504  EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563

Query: 1133 YCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQME-------QSRRKQQMEME 1185
               L+ E  ER+    K      ++++  + +     R + E       + RR+Q+++ E
Sbjct: 564  EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKRE 623

Query: 1186 IAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNY 1245
              + E+     K  ++ ERR    +  +  Q    +    +++  + ++  +  + E   
Sbjct: 624  EPEEERRQQLLKSEEQEERR---QQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680

Query: 1246 RSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDE----KVLPYSNIT 1301
            R      E+ E+       R   +    +     R   V   P+  E    +        
Sbjct: 681  REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740

Query: 1302 VREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSF--PNSI 1359
             RE  L++   + + R+Q  +  +         D   +W ++ K + GR  +S   P   
Sbjct: 741  RRESELQWQEEERAHRQQQEEEQR--------RDFTWQWQAEEKSERGRQRLSARPPLRE 792

Query: 1360 IKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALY---ESSRL-----SFLLRDR 1411
             +   LR    +  E   +P + +++   +    R   L    E  +L     +  L++ 
Sbjct: 793  QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852

Query: 1412 EDKLRE-RDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSR 1470
            ED L+E ++ R S    R++ + + L++        L  +       R+E     + +  
Sbjct: 853  EDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEE 912

Query: 1471 FANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRF 1530
                R  ++K +     R     Y ++++++ + E  + +++E  + +E+ERQ       
Sbjct: 913  LQ--REEREKRRRQEQERQ----YREEEQLQQEEEQLLREEREKRRRQERERQ------- 959

Query: 1531 LHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMEL 1590
                 + +D K    L++KEE       ++ G++  +      +           ++ E 
Sbjct: 960  -----YRKDKK----LQQKEE-------QLLGEEPEKRRRQERE----------KKYREE 993

Query: 1591 TRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELK 1632
              +QQ+E++  ++ +E  ++++ E   +  +   + ++  L+
Sbjct: 994  EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 198/1031 (19%), Positives = 392/1031 (38%), Gaps = 125/1031 (12%)

Query: 611  EMLAERREERRASY---DYNQDRTYYESV-RTPGTYPEDSRRDYPARGREFYSEWETYQG 666
            ++L E RE+RR       Y +D+   +   +  G  PE  RR    R +++  E E  Q 
Sbjct: 942  QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ--EREKKYREEEELQQE 999

Query: 667  DYY-------ESRYYDDPREYR--DYRNDPYEQDIREYSYRQRERERERERFESDRDRDH 717
            +         + R  +  R+YR  D      EQ +RE   ++R +ERER+  E +  +  
Sbjct: 1000 EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059

Query: 718  ERRPIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYS-----RSSDRSGSCSSLSPP 772
            E + +   +     RR Q       + E L  + E+ L       R  +R   C      
Sbjct: 1060 EEQLLGEERET---RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116

Query: 773  RYEKLDKSRLERYTKNEKTDKERTF-DPERVERERRLIRKEKVEKDKTDKQKRKGKVHSP 831
            + E+    R ER  K  + + ER + + E V++E   + +E+ EK +  + +R+ +    
Sbjct: 1117 QQEEEQLLREER-EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175

Query: 832  SSQSSET----DQENEREQSPEKPRSCNKLSREKA-----DKEGIAKNRLELMPCVVLTR 882
              Q  E     +QE  R++   + R   +L R+K      D++  +  + +  P      
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEP------ 1229

Query: 883  VKEKEGKVIDHTPVEKLKA-----KLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRM 937
              EKE  V D+    K +      +L++  ++     Q LQ    E  + D    E  R 
Sbjct: 1230 --EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR---EQERR 1284

Query: 938  KVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEK 997
            +  +        E +E+E + +A++  +  Q  +    +  E+ E R+R+  D   + E+
Sbjct: 1285 RWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ--EEKQLLREEREEKRRRQETDRKFREEE 1342

Query: 998  QKPEVKKSSPEMEDARVLSKKQPDVSSREV---ILLREGEAERKPVRKEILKRESKKIKL 1054
            Q  + ++  P     R    ++ ++  +E     L  E    R+   ++ LK E +    
Sbjct: 1343 QLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQ 1402

Query: 1055 DRLNTVASPKDC---QELASISVGSGSRP--SSDLQARLGELAGESVEN-QEVQSKKPIP 1108
            +R   +   +D    +E   +S     R     + Q R  E   + +E  Q+++ ++   
Sbjct: 1403 EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK 1462

Query: 1109 SKPQLKQLQVLDDQGPEREDVRKNYCS----LRDETPERKSGQEKSHSVNTEEKIGIDID 1164
             + + + LQ  ++Q   R++  + +      LR +  +RK  +++  S   E K    ++
Sbjct: 1463 FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF---LE 1519

Query: 1165 HTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPP 1224
              Q   +Q  Q R+  Q E ++ + E+    ++D D   R        +  Q ++     
Sbjct: 1520 EEQQLHRQQRQ-RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD 1578

Query: 1225 SKKKRMDHVDFDICTKRERNYRSSRQISEDSE---RTGGSPSVRHG---SFHEDEDPIGS 1278
             K        F +  ++ R     R+  ED +   R  G   +R      F EDE  +  
Sbjct: 1579 RK--------FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQE 1630

Query: 1279 PRLLSVKGSPKVDEKVL---PYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSED 1335
                 +    + D K L   P      RE+ L+ +     R E+       +L     E 
Sbjct: 1631 REEQQLHRQER-DRKFLEEEPQLRRQEREQQLRHDRDRKFREEE-------QLLQEGEEQ 1682

Query: 1336 ELNRWDSQMK----QDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSH 1391
            +L R +   K    +   R        + +   LR++ +      E     + + E    
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742

Query: 1392 SPRASALYESSRL------SFLLRDREDKLRERDERLSSSLERNKFYSFALDKTITPDTK 1445
              R   + E  +L        L R   D+    +E+L    E  +  S   D+    + +
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQ 1802

Query: 1446 ALLERAKSLSSSREENWSF------LDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKK 1499
               ER +     ++ +  +      L  + +    R  +D++            Y  +++
Sbjct: 1803 LRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQ------------YRAEEQ 1850

Query: 1500 IRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGR 1559
              T  + + ++++   +EE++ RQE    +     I  Q  +  +H +  E  S    G+
Sbjct: 1851 FATQEKSRREEQELWQEEEQKRRQER-ERKLREEHIRRQQKEEQRHRQVGEIKSQ--EGK 1907

Query: 1560 IYGKQTSEGAN 1570
             +G+    G +
Sbjct: 1908 GHGRLLEPGTH 1918



 Score = 80.5 bits (197), Expect = 3e-14
 Identities = 242/1343 (18%), Positives = 511/1343 (38%), Gaps = 187/1343 (13%)

Query: 773  RYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPS 832
            R+E  D+ +LE      +  K +  + E  E E +  ++E++E+   D+Q+R  ++    
Sbjct: 121  RFEPRDR-QLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQ--RDRQRRDEELWR-- 175

Query: 833  SQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRV------KEK 886
             Q  E  +  ER    E+ +SC     E+   E   + R EL+      R       +E+
Sbjct: 176  -QRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR-ELLELRRKGREEKQQQRRER 233

Query: 887  EGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQTEPAKS-DLSKLESVRMKVPKEKGL 945
            + +V      E+ K     +TV     ++KLQ  + EP +  +L + E    K+ +++  
Sbjct: 234  QDRVFQE---EEEKEWRKRETVLRKE-EEKLQ--EEEPQRQRELQEEEEQLRKLERQELR 287

Query: 946  SSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKS 1005
                E  +++ RL+  + L+ +Q  +       E+ E R+ +      + E+++ ++++ 
Sbjct: 288  RERQEEEQQQQRLRREQQLRRKQEEER-----REQQEERREQQERREQQEERREQQLRRE 342

Query: 1006 SPEMEDARVLSKKQPDVSSREVILLREGEAERKPV---RKEILKRESKKIKLDRLNTVAS 1062
              E  + ++  +++ +   RE  L RE E ER+     R++ L+RE +  +  +L     
Sbjct: 343  QEERREQQL--RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ 400

Query: 1063 PKDCQELA---SISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVL 1119
             +  Q+L     +      R    L+    E   E    QE + ++    + + +     
Sbjct: 401  LRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR 460

Query: 1120 DDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSR-- 1177
            +++    E  R+     RD+  ER+   E+   +  EE+        Q  R++ E+ R  
Sbjct: 461  EEETERHEQERRKQQLKRDQEEERR---ERWLKLEEEERREQQERREQQLRREQEERREQ 517

Query: 1178 RKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDI 1237
            R ++ E E    ++  S ++   E E R       +  + +  +    + KR      D 
Sbjct: 518  RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577

Query: 1238 CTKRERNYRSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPY 1297
              KRE   R  R   E  ER             E E+     R   +K     +E+    
Sbjct: 578  LLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER----REQRLKREEPEEER---- 629

Query: 1298 SNITVREESLKFNPYDSSRREQMA-DMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFP 1356
                 R++ LK    +  R++Q+  +  + +   L  E+E  R + ++K++         
Sbjct: 630  -----RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684

Query: 1357 NSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDR---ED 1413
             +  +++  R+R    +   +   +S+ D        R S +Y   R     R R   E+
Sbjct: 685  LAEEEQEQARERIKSRIPKWQWQLESEADA-------RQSKVYSRPRKQEGQRRRQEQEE 737

Query: 1414 KLRERDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFAN 1473
            K R R+  L    E                     ERA       E+   F  W  + A 
Sbjct: 738  KRRRRESELQWQEE---------------------ERAHRQQQEEEQRRDFT-WQWQ-AE 774

Query: 1474 FRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHS 1533
             ++ + ++++ + P   P    +++++R +   + + +    +EE+++R+     R    
Sbjct: 775  EKSERGRQRLSARP---PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER---- 827

Query: 1534 SIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRM 1593
                   K LQ LE +E+        +  ++ ++      D +QE          +  R 
Sbjct: 828  ------EKELQFLEEEEQ--------LQRRERAQQLQEEEDGLQE----------DQERR 863

Query: 1594 QQKEKEKDQKPK-EVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPS 1652
            + +E+ +DQK + ++E++     H                             TL + P+
Sbjct: 864  RSQEQRRDQKWRWQLEEERKRRRH-----------------------------TLYAKPA 894

Query: 1653 ALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEA 1712
              E+   ++ +   L  EE+ ++     +  +   E      EQL+Q         ++E 
Sbjct: 895  LQEQLRKEQQL---LQEEEEELQREEREKRRRQEQERQYREEEQLQQ---------EEEQ 942

Query: 1713 AMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNV---DPEPDSTQPLSKPAQKSEEA 1769
             +     +      +  Y   K         Q E  +   +PE    Q   K  ++ EE 
Sbjct: 943  LLREEREKRRRQERERQYRKDK------KLQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996

Query: 1770 NEPKAE--KPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTP 1827
             + + +  + +       +  ++     E Q    + L  +       ++  + +  +  
Sbjct: 997  QQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056

Query: 1828 VQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADL 1887
             Q     + E+  TR+ + ++R+  K     + E Q L E   +  +  R        +L
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116

Query: 1888 EHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPV--EQPRVTRKR-LERELQEAAAV 1944
            +  E  L      +R  + +     + E     +E +  E+P   R++ LER+ +E   +
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEEL 1176

Query: 1945 PTTPRRG-RPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGG-PQGKKGKN 2002
                 +  R  + +RR + E +   +E  +  K  + +R    +        P+ +    
Sbjct: 1177 QQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR 1236

Query: 2003 EPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEA----GSEQKRDRKDAGT-----DKN 2053
            + KV     E   E   Q+  ++S +  + ++++     G +Q+RDR+         D++
Sbjct: 1237 DNKVYCKGRE--NEQFRQL--EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292

Query: 2054 PPETAPVEVVEKKPAPEKNSKSK 2076
             PE   +E  E+K A  ++ KS+
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQ 1315



 Score = 76.3 bits (186), Expect = 5e-13
 Identities = 162/942 (17%), Positives = 366/942 (38%), Gaps = 84/942 (8%)

Query: 732  RRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKT 791
            +R +  G      +R   + +RR   R              R +K  +   E     E++
Sbjct: 99   KRARCDGKESLLQDRRQEEDQRRFEPRDRQLE---EEPGQRRRQKRQEQERELAEGEEQS 155

Query: 792  DKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQSPEKP 851
            +K+     ER+E+  R  R E++ + + + Q+R+ +        S    E E     E+ 
Sbjct: 156  EKQ-----ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210

Query: 852  RSCNKLSREKADKEGIAKNRLELMPCVVL-----------TRVKEKEGKVIDHTPVEKLK 900
            R    L   +  +E   + R E    V             T ++++E K+ +  P  + +
Sbjct: 211  RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE 270

Query: 901  AKLDNDTV-KSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLK 959
             + + + + K    + + +  + E  +  L + + +R K  +E+      E  E+    +
Sbjct: 271  LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR-----EQQEERREQQ 325

Query: 960  ARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQ 1019
             R+  + E+    +     E+ E + RR  +   + ++ + E ++   E +  R    ++
Sbjct: 326  ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385

Query: 1020 PDVSSREVILLREGEAER-------KPVRKEILKRESKKIKLDRLNTVASPKDCQELASI 1072
                 RE  L RE +  R       + +R+E   R  ++++ ++       K  QE    
Sbjct: 386  EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445

Query: 1073 SVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKN 1132
             +        D   R  E      E ++ Q K+    + + + L++ +++  E+++ R+ 
Sbjct: 446  RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505

Query: 1133 YCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRR---KQQMEMEIAKS 1189
               LR E  ER+  +++      EE++   +   Q  R++ E+ R    K++ E  + + 
Sbjct: 506  --QLRREQEERR--EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561

Query: 1190 EKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSR 1249
             +    K++ +E   + L  E  +  Q +  +     ++R+   + +   + ER  +  +
Sbjct: 562  RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621

Query: 1250 QISEDSERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVREESLKF 1309
            +   + ER       R      +E      + L  +   + ++++         E+ LK 
Sbjct: 622  REEPEEER-------RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK- 673

Query: 1310 NPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRS 1369
              ++  RREQ     + + +    +  + +W  Q++ +A        +   K++  R+R 
Sbjct: 674  REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ 733

Query: 1370 VRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLR-DREDK-------------L 1415
             ++ +     S+     E ++H  +     E  R  F  +   E+K             L
Sbjct: 734  EQEEKRRRRESELQWQEEERAHRQQQE---EEQRRDFTWQWQAEEKSERGRQRLSARPPL 790

Query: 1416 RERDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFR 1475
            RE+ ER   + ER +      ++   P+ +   +R +     RE+   FL+ + +     
Sbjct: 791  REQRERQLRAEERQQ-----REQRFLPEEEEKEQRRRQ-RREREKELQFLEEEEQLQRRE 844

Query: 1476 NNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSI 1535
              +  ++ +           + ++ R   E + D K     EEE++R+    + +   ++
Sbjct: 845  RAQQLQEEEDG-------LQEDQERRRSQEQRRDQKWRWQLEEERKRRR--HTLYAKPAL 895

Query: 1536 FEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQ 1595
             EQ  K  Q L+ +EE+          +Q  E      + +Q+          E  R Q+
Sbjct: 896  QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955

Query: 1596 KEKE--KDQKPKEVEKQ---EDTENHPKTPESAPENKDSELK 1632
            +E++  KD+K ++ E+Q   E+ E   +        ++ EL+
Sbjct: 956  RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ 997



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 128/689 (18%), Positives = 268/689 (38%), Gaps = 74/689 (10%)

Query: 601  KSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYPARGREFYSE 660
            +S QD++       ER  E+       +DR + E  +      ++++R    R R+   E
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKR----RDRKSQEE 1317

Query: 661  WETYQGDYYESRYYDDP-REYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHER 719
             +  + +  E R   +  R++R+      E+ + +    Q  R +ER+R   + +  H+ 
Sbjct: 1318 KQLLREEREEKRRRQETDRKFRE------EEQLLQEREEQPLRRQERDRKFREEELRHQE 1371

Query: 720  RPIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDK 779
            +  +  +    LRR +       + ++L      +   +  DR          R E+ D+
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER-DR 1430

Query: 780  SRLERYTKNEKTDKERTFDPE----RVERERRLIRKEKV----EKDKTDKQKRKGKVHSP 831
               E   +  + ++ER F  E    R ER R+   +E++    E+ +  +Q+R  K    
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490

Query: 832  SSQSSETDQENE-REQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKV 890
              Q    +++ + REQ         K   E+       + R  L     L R +  + + 
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550

Query: 891  IDH----TPVEKLKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLS 946
             D        E+L+ + +   +     D+K ++ +           + VR +  + K + 
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE-----------QKVRRQEQERKFME 1599

Query: 947  SHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSS 1006
               ++  +EG+ + R+    +   D      L++ E ++    + + K  +++P++++  
Sbjct: 1600 DEQQLRRQEGQQQLRQERDRKFREDEQL---LQEREEQQLHRQERDRKFLEEEPQLRRQE 1656

Query: 1007 PEMEDARVLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDC 1066
             E +    L   +      E  LL+EGE ++  +R++   R+ ++ +          K  
Sbjct: 1657 REQQ----LRHDRDRKFREEEQLLQEGEEQQ--LRRQERDRKFREEEQQLRRQERERKFL 1710

Query: 1067 QELASISVGSGSRPSSDLQARLGELAGESVENQEVQSK-------KPIPSKPQLKQLQVL 1119
            QE   +      R   + +    E   E +  QE   K       +P   + QL++ Q  
Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR-QER 1769

Query: 1120 DDQGPEREDVR--KNYCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQ-- 1175
            D +  E E +R  +    LR +  +RK  +E+      EE+          YR + EQ  
Sbjct: 1770 DRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ 1829

Query: 1176 -----SRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRM 1230
                  R +Q+ + +    E+F + +K   E E+     E  K  Q+        +K R 
Sbjct: 1830 LEEQEQRLRQERDRQYRAEEQFATQEKSRRE-EQELWQEEEQKRRQE------RERKLRE 1882

Query: 1231 DHVDFDICTKRERNYRSSRQISEDSERTG 1259
            +H+      ++++  +  RQ+ E   + G
Sbjct: 1883 EHI-----RRQQKEEQRHRQVGEIKSQEG 1906



 Score = 49.3 bits (116), Expect = 7e-05
 Identities = 101/577 (17%), Positives = 203/577 (35%), Gaps = 49/577 (8%)

Query: 1842 RKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAAD-LEHPEPSLPLSRTR 1900
            R+ + + RE+ +R    + E ++ LE +++ E++ R   +      L+  EP       R
Sbjct: 574  RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE---EERR 630

Query: 1901 RRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRA 1960
            ++ ++S      + E R   +   EQ     +RL+RE +E        R     +  +  
Sbjct: 631  QQLLKSE-----EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQEL 685

Query: 1961 DEEEENEAKEPAETLKPPEGWR------SPRSQKTAAGGGPQGKKGKNEPKVDATRPEAT 2014
             EEE+ +A+E  ++  P   W+      + +S+  +     +G++ + E +    R E+ 
Sbjct: 686  AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745

Query: 2015 TEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDK---NPP---------ETAPVEV 2062
             +   +        E +   +     Q  ++ + G  +    PP              + 
Sbjct: 746  LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQ 805

Query: 2063 VEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPE 2122
             E++  PE+  K +R R R  R   +K       +  +  R  A Q  E E G+      
Sbjct: 806  REQRFLPEEEEKEQRRRQRRER---EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862

Query: 2123 KSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPE----ATQLAKQMELEQAVEHI 2178
            +    Q+ D    Q     ++ +++  +  + A     E      QL ++ E E   E  
Sbjct: 863  RRSQEQRRD----QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918

Query: 2179 AKLAEASASAAYKAD-----APEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENF 2233
             K         Y+ +       E L  E+R+K   Q  E +           +  + E  
Sbjct: 919  EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD-----KKLQQKEEQL 973

Query: 2234 PAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSA 2293
                P     Q   +     + LQ  EE +  +E      +        +  +   +   
Sbjct: 974  LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL 1033

Query: 2294 GPTDTKEARGNSSETSHSVPEAKGSKEVEVT-LVRKDKGRQKTTRSRRKRNTNKKVVAPV 2352
               + ++ R    E  +   E    +E ++    R+ + RQ+  R  RK    ++    +
Sbjct: 1034 LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093

Query: 2353 ESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEK 2389
                PE  + Q       E   +Q  E     ++ EK
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score =  102 bits (254), Expect = 7e-21
 Identities = 196/874 (22%), Positives = 298/874 (34%), Gaps = 176/874 (20%)

Query: 2656 GLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTT---PVN 2712
            GL NV+L P+  L+G   GS     +  +    P+ V+  PV  L  P + L     PV+
Sbjct: 202  GLGNVTLQPIPGLQGLPNGSPGGATA-ATLGLAPIQVVGQPVMALNTPTSQLLAKQVPVS 260

Query: 2713 ATVGTVNAAPGTVNAAASAVN------------ATASAVTVTAGAVTAASGGVTATTGTV 2760
              + +       V  A++ V+            + A A T+   +V   +G  +A TGT 
Sbjct: 261  GYLASAAGPSEPVTLASAGVSPQGAGLVIQKNLSAAVATTLNGNSVFGGAGAASAPTGTP 320

Query: 2761 TMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPAD--------------AGSGAGL 2806
            +     +AP         A  N   H    P I  +PA               A +GA L
Sbjct: 321  SGQPLAVAPGLGSSPLVPA-PNVILHRTPTP-IQPKPAGVLPPKLYQLTPKPFAPAGATL 378

Query: 2807 RVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQV--KPDSVTAS 2864
             +    G +      Q+ + PQ ++   +     + +   F     ++ V  +P + T  
Sbjct: 379  TIQGEPGAL-----PQQPKAPQNLTFMAAGKAGQNVVLSGFPAPALQANVFKQPPATTTG 433

Query: 2865 QPPSKGPQA---PAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVST 2921
              P + P A   P     +   S++V+ AQ +        +    P+++ P+ +    + 
Sbjct: 434  AAPPQPPGALSKPMSVHLLNQGSSIVIPAQ-HMLPGQNQFLLPGAPAVQLPQQLS---AL 489

Query: 2922 PVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGST 2981
            P   GG +      +         QL+  P  + TN+ LA P+            +LG  
Sbjct: 490  PANVGGQI------LAAAAPHTGGQLIANP--ILTNQNLAGPL------------SLGPV 529

Query: 2982 LTPH---HPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHS-PRPSGPGPSSFP 3037
            L PH   H   + S  P +V   P+   +P       LAA  L   S P P+GP  +   
Sbjct: 530  LAPHSGAHSAHILSAAPIQVGQ-PALFQMPVS-----LAAGSLPTQSQPAPAGPAAT--- 580

Query: 3038 RASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGE 3097
                             TV+    +P P  ++ ++    ++ P    T   +    +   
Sbjct: 581  -----------------TVLQGVTLP-PSAVAMLNTPDGLVQP---ATPAAATGEAAPVL 619

Query: 3098 VRMNTPTLPSITYSIRPEALHSPRAPLQPQ--QIEVRAPQRASTPQPAPAGVPALASQHP 3155
                 P  P    +  P  L  P+A   PQ    +  AP +A+TPQP+    P LAS   
Sbjct: 620  TVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPS----PGLASS-- 673

Query: 3156 PEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADG 3215
            PE+ V    P A  TA +  + L M          +  +   +  P    VS  P A D 
Sbjct: 674  PEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDP 733

Query: 3216 VVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPS 3275
                P A  A   P     + PD++A+P P P    +P   P   P P     +    P 
Sbjct: 734  APATPVAKGAGLGP-----QAPDSQASPAPAP---QIPAAAPLKGPGPSSSPSLPHQAPL 785

Query: 3276 NQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPS 3335
                 LP   P                             PP++          SV  P 
Sbjct: 786  GDSPHLPSPHPT---------------------------RPPSRPP----SRPQSVSRPP 814

Query: 3336 RTKTAAQGPPPEGEPLQP-----------PQPVQSTQPAQPAPPCPP----SQLGQPGQP 3380
                    PPP+  P  P           P P  +  P  P PP PP    SQ  +   P
Sbjct: 815  SEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLP 874

Query: 3381 PSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMK 3440
            P+  +P  S  +    +     RLPA      P P     +     GP   P+P      
Sbjct: 875  PAPHLPPSSTSSAVASSSETSSRLPA------PTPSDFQLQFPPSQGPHKSPTP------ 922

Query: 3441 PDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLP 3474
            P     +P   AP  P   P T    T P   LP
Sbjct: 923  PPTLHLVPEPAAPPPP--PPRTFQMVTTPFPALP 954



 Score = 76.6 bits (187), Expect = 4e-13
 Identities = 187/818 (22%), Positives = 277/818 (33%), Gaps = 121/818 (14%)

Query: 2774 KQRASANENSRFHPGSMPVIDDRPADAGSG---AGLRVNTSEGVVLLSYSGQKT----EG 2826
            +Q   A       P  +P +  +PAD G+G   AG     + G   L + G       +G
Sbjct: 115  EQTLEAEAELDLGPFQLPTL--QPADGGAGPTGAGGAAAVAAGPQAL-FPGSTDLLGLQG 171

Query: 2827 PQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQA-PAGYANVATHST 2885
            P  +    + +PP   ++           V   +VT    P  G Q  P G    AT +T
Sbjct: 172  PPTVLTHQALVPPQDVVNKALSVQPFLQPVGLGNVTLQ--PIPGLQGLPNGSPGGATAAT 229

Query: 2886 LVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHN 2945
            L L        PV++        L K  P+   +++       V + + G++     +  
Sbjct: 230  LGLAPIQVVGQPVMALNTPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVI 289

Query: 2946 QLVLTPSIVTT---NKKL--ADPVTLKIETKVLQPA----NLGSTLTPHHPPALPSKLPT 2996
            Q  L+ ++ TT   N     A   +    T   QP      LGS+     P  +  + PT
Sbjct: 290  QKNLSAAVATTLNGNSVFGGAGAASAPTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPT 349

Query: 2997 EVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATV 3056
             +   P+G   P           KL   +P+P  P  ++      P +      +     
Sbjct: 350  PIQPKPAGVLPP-----------KLYQLTPKPFAPAGATLTIQGEPGALPQQPKAPQNLT 398

Query: 3057 MLAAG----------IPVPQFISSIHPEQSVI-------MPPHSITQTVSLSHLSQGEVR 3099
             +AAG           P P   +++  +            PP ++++ +S+  L+QG   
Sbjct: 399  FMAAGKAGQNVVLSGFPAPALQANVFKQPPATTTGAAPPQPPGALSKPMSVHLLNQGSSI 458

Query: 3100 M----------NTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAP----- 3144
            +          N   LP       P+ L +  A +  Q +   AP         P     
Sbjct: 459  VIPAQHMLPGQNQFLLPGAPAVQLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQ 518

Query: 3145 --AGVPALASQHPPEEEVHY-HLPVARATAPVQ-SEVLVMQSEYRLHPYTVPRDVR-IMV 3199
              AG  +L     P    H  H+  A   AP+Q  +  + Q    L   ++P   +    
Sbjct: 519  NLAGPLSLGPVLAPHSGAHSAHILSA---APIQVGQPALFQMPVSLAAGSLPTQSQPAPA 575

Query: 3200 HPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAP-----VPVPV 3254
             P  T V +        V +        QP   AA T +A    T  PAP     V  P+
Sbjct: 576  GPAATTVLQGVTLPPSAVAMLNTPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPL 635

Query: 3255 PL---------PAPAPAPHGEA--RILTVTPSNQLQGLP----LTPPVVVTHGVQIVHSS 3299
            PL         P  AP P   A  +  T  PS  L   P    L  P   T    +   S
Sbjct: 636  PLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDS 695

Query: 3300 GELFQEYRYGDIRTYHP-PAQLTHTQFPAASSVGLPSRTKTAAQGPP-PEGEPLQPPQPV 3357
             ++F        R+  P  A+  H   PA+  V  P   +  A   P  +G  L P  P 
Sbjct: 696  LQMFLPQE----RSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPD 751

Query: 3358 QSTQPAQPAPPCPPSQ-LGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPH 3416
                PA PAP  P +  L  PG   S  +P   Q   G    +  P  P  P +RPP   
Sbjct: 752  SQASPA-PAPQIPAAAPLKGPGPSSSPSLPH--QAPLGDSPHLPSPH-PTRPPSRPPSRP 807

Query: 3417 TQVQRAQAETGPTSFPSPVSVSMKPDL-----------PVSLPTQTA--PKQPLFVPTTS 3463
              V R  +E      P P +    P +           P S P  TA  P QP   P + 
Sbjct: 808  QSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQ 867

Query: 3464 GPSTP----PGLVLPHTEFQPAPKQDSSPHLTSQRPVD 3497
             P  P    P L    T    A   ++S  L +  P D
Sbjct: 868  PPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSD 905



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 150/624 (24%), Positives = 227/624 (36%), Gaps = 97/624 (15%)

Query: 2837 IPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGP------------QAPAGYANVATHS 2884
            +P A A+ +  Q S   + V    + A+ P + G               P     V    
Sbjct: 474  LPGAPAVQLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGPLSLGPVLAPH 533

Query: 2885 TLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSV------STPVTQGGTVKVLTQGINT 2938
            +   +A   +A+P+    +  +P+L +  P+ L+       S P   G     + QG+  
Sbjct: 534  SGAHSAHILSAAPI----QVGQPALFQM-PVSLAAGSLPTQSQPAPAGPAATTVLQGVTL 588

Query: 2939 PPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEV 2998
            PP  V        +++ T   L  P T    T    P  L     P  PPA+ + LP  +
Sbjct: 589  PPSAV--------AMLNTPDGLVQPATPAAATGEAAPV-LTVQPAPQAPPAVSTPLPLGL 639

Query: 2999 NHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPR----ASHPSSTASTALSTNA 3054
               P     P   T    AAA   A +P+PS PG +S P        PS+T +  L+ ++
Sbjct: 640  QQ-PQAQQPPQAPTPQ--AAAPPQATTPQPS-PGLASSPEKIVLGQPPSATPTAILTQDS 695

Query: 3055 TVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRP 3114
              M        Q +S+  P  SV   P S+   VS    +Q      TP        + P
Sbjct: 696  LQMFLPQERSQQPLSAEGPHLSV---PASVI--VSAPPPAQDPAPA-TPVAKGA--GLGP 747

Query: 3115 EALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQ 3174
            +A  S  +P    QI   AP +     P P+  P+L  Q P  +  H  LP    T P  
Sbjct: 748  QAPDSQASPAPAPQIPAAAPLKG----PGPSSSPSLPHQAPLGDSPH--LPSPHPTRPPS 801

Query: 3175 ------SEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQ----PRAADGVVKVP---- 3220
                    V    SE  LHP   P+    +  P +  +  Q    P A++     P    
Sbjct: 802  RPPSRPQSVSRPPSEPPLHPCPPPQAPPTL--PGIFVIQNQLGVPPPASNPAPTAPGPPQ 859

Query: 3221 ----PASKAPQQPGKEA-----AKTPDAKAAPTPTPAPVPVPVP--LPAPAPAPHGEARI 3269
                P S+ P+ P   A     + T  A A+ + T + +P P P       P   G  + 
Sbjct: 860  PPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKS 919

Query: 3270 LTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPA----QLTHTQF 3325
             T  P+  L   P  PP       Q+V +      + +    R +  P+    Q      
Sbjct: 920  PTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGA 979

Query: 3326 PAA--SSVGLPSRTKTAA----QGPPPEGEPLQPPQ-PVQSTQPAQPAPPCPPSQLGQPG 3378
            PAA  +S  L   T  AA     G  P G P  P   P  +   A   PP  P++     
Sbjct: 980  PAAPQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPMAATGLPPLLPAE----N 1035

Query: 3379 QPPSSKMPQVSQEAKGTQTGVEQP 3402
            +  +S +P ++  AK   +G  +P
Sbjct: 1036 KAFASNLPTLN-VAKAASSGPGKP 1058



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 83/368 (22%), Positives = 121/368 (32%), Gaps = 54/368 (14%)

Query: 2228 GEPENFPAPPPYP-GESQTDLQP-PAGAQALQPSEEGMETDEAVSGILETEAATESSRPP 2285
            G+P  F  P     G   T  QP PAG               A + +L+      S+   
Sbjct: 550  GQPALFQMPVSLAAGSLPTQSQPAPAGP--------------AATTVLQGVTLPPSAVAM 595

Query: 2286 VNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTN 2345
            +N PD    P     A G ++      P  +    V   L     G Q+    +  +   
Sbjct: 596  LNTPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPL---PLGLQQPQAQQPPQAPT 652

Query: 2346 KKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSD-LSK 2404
             +  AP ++  P+ +     SP              ++    + P +TP    T D L  
Sbjct: 653  PQAAAPPQATTPQPSPGLASSP--------------EKIVLGQPPSATPTAILTQDSLQM 698

Query: 2405 IPSTENSSQEISVE-ERTPTKASVPPDLPPPPQ-PAPVDEEPQARFRVHSIIESDPVTPP 2462
                E S Q +S E       ASV    PPP Q PAP     +            P  P 
Sbjct: 699  FLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGA-------GLGPQAPD 751

Query: 2463 SDPS-IPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPD 2521
            S  S  P P +P+    K   P +S  +PHQ+P           + P   S P P  PP 
Sbjct: 752  SQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAP---------LGDSPHLPS-PHPTRPPS 801

Query: 2522 TKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKP 2581
               S   + S    +  + P        T   +     +     P  + AP  P   + P
Sbjct: 802  RPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPP 861

Query: 2582 LEEKTAPP 2589
            L  ++ PP
Sbjct: 862  LRPQSQPP 869



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 109/467 (23%), Positives = 164/467 (35%), Gaps = 71/467 (15%)

Query: 2187 SAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTD 2246
            SA    + P+GL      +PA  A+ T  AA + ++       P+   APP         
Sbjct: 591  SAVAMLNTPDGLV-----QPATPAAATGEAAPVLTV----QPAPQ---APPAVSTPLPLG 638

Query: 2247 LQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSS 2306
            LQ P   QA QP +    T +A            ++ P    P PS G   + E      
Sbjct: 639  LQQP---QAQQPPQA--PTPQA------------AAPPQATTPQPSPGLASSPEKIVLGQ 681

Query: 2307 ETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGES 2366
              S + P A  +++     + +++ +Q  +      +    V+  V +  P  + A    
Sbjct: 682  PPS-ATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVI--VSAPPPAQDPAPATP 738

Query: 2367 PAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKAS 2426
             A   G   Q P+       S+   +  PQ   +   K P   +S    S+  + P   S
Sbjct: 739  VAKGAGLGPQAPD-------SQASPAPAPQIPAAAPLKGPGPSSSP---SLPHQAPLGDS 788

Query: 2427 VPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLS---PP 2483
              P LP P    P    P     V       P+ P   P  P PTLP +   +     PP
Sbjct: 789  --PHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAP-PTLPGIFVIQNQLGVPP 845

Query: 2484 VASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKY 2543
             AS   P    P +      + + P     P+P LPP + +S V +SS T          
Sbjct: 846  PASNPAPTAPGPPQ-PPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSET---------- 894

Query: 2544 VSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLV 2603
             S+     T     +  P S  P  H++P PP       E    PP    +    +    
Sbjct: 895  -SSRLPAPTPSDFQLQFPPSQGP--HKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFP 951

Query: 2604 AADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGL 2650
            A  + K        +     ++P  I L+N  K   A  APQT T L
Sbjct: 952  ALPQPKA-------LLERFHQVPSGIILQN--KAGGAPAAPQTSTSL 989



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 58/240 (24%), Positives = 95/240 (39%), Gaps = 27/240 (11%)

Query: 1596 KEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKT----PPSVGPPSVTVVTLESAP 1651
            ++ +  Q P+    Q        TP+ +P    S  K     PPS  P ++  +T +S  
Sbjct: 640  QQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAI--LTQDSLQ 697

Query: 1652 SAL--EKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPA-PVEQLEQVDLPPGADP 1708
              L  E++    + E P ++    V  + +     PA +PAPA PV +     L P A P
Sbjct: 698  MFLPQERSQQPLSAEGPHLS----VPASVIVSAPPPAQDPAPATPVAK--GAGLGPQA-P 750

Query: 1709 DKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEE 1768
            D +A+  PA     ++  + P   + P  P  +    +S   P P  T+P S+P  + + 
Sbjct: 751  DSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQA-PLGDSPHLPSPHPTRPPSRPPSRPQS 809

Query: 1769 ANEPKAE---KPDATADAEPD-------ANQKAEAAPESQPPASEDLEVDPPVAAKDKKP 1818
             + P +E    P     A P         NQ     P S P  +      PP+  + + P
Sbjct: 810  VSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPP 869



 Score = 37.7 bits (86), Expect = 0.21
 Identities = 144/719 (20%), Positives = 230/719 (31%), Gaps = 94/719 (13%)

Query: 1616 HPKTPESAPENKDSELKTPPSVGP-------------PSVTVVTLESA---PSALEKTTG 1659
            HP  P S P ++   +  PPS  P             P + V+  +     P++    T 
Sbjct: 795  HPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTA 854

Query: 1660 DKTVEAPLVTEEKTVE----------PATVSEEAKPASEPA---PAPVEQLEQVDLPPGA 1706
                + PL  + +  E          P++ S     +SE +   PAP     Q+  PP  
Sbjct: 855  PGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQ 914

Query: 1707 DPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQ-- 1764
             P K     P       +    P   A PP P  +F    +     P     L +  Q  
Sbjct: 915  GPHKSPTPPP-------TLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVP 967

Query: 1765 -----KSEEANEPKAEKPDATADAEPDANQKAEA-----APESQPPASEDLEVDPPVAAK 1814
                 +++    P A  P  +    P  +  A       AP   P A        P+AA 
Sbjct: 968  SGIILQNKAGGAPAA--PQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPMAAT 1025

Query: 1815 DKKP-----NKSKRSKTP---VQAAAVSIVEKPVTRKSE-RIDREKLKRSNSPRGEAQKL 1865
               P     NK+  S  P   V  AA S   KP   + E ++   K   +  P  EA  L
Sbjct: 1026 GLPPLLPAENKAFASNLPTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTLQPSKEACFL 1085

Query: 1866 LELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNV-RSVYATMGDHENRSPVKEPV 1924
              L      +     K +    E       L R    +V +    +  D+       E V
Sbjct: 1086 EHLHKHQGSVLHPDYKTAFPSFED-----ALHRLLPYHVYQGALPSPSDYHKVDEEFETV 1140

Query: 1925 EQPRVTRKRLERELQEAAAVPTTPRRGRPPKT------RRRADEEEENEA--KEPAETLK 1976
                +  KR +  L +   +     R   P        R    EE+   A  K+ A+  K
Sbjct: 1141 STQLL--KRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEEKTTLALDKQLAKE-K 1197

Query: 1977 PPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEE 2036
            P E   S RS         +G +      + ++ P A+T+  P +  K       A    
Sbjct: 1198 PDEYVSSSRSLGLPIAASSEGHRLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGSP 1257

Query: 2037 AGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNS---KSKRGRSR-NSRLAVDKSAS 2092
            + +  +     + +  +    + ++  E  P P +N    K+   RSR   +L + + A 
Sbjct: 1258 SVTWARASSSLSSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAG 1317

Query: 2093 LKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKED 2152
            L  V    +            +  VA  P +   P    G  +     P  P   PE++ 
Sbjct: 1318 LSKVVHNTALDPVHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHP--PPAAPERKP 1375

Query: 2153 VSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASE 2212
            +   G +P   +L  +    + V          A     A    G +P        +A+ 
Sbjct: 1376 L---GTAPHCPRLPLRKTYRENV------GGPGAPEGTPAGRARGGSPAPLPAKVDEATS 1426

Query: 2213 ---TELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEA 2268
                ELAA    +   +   P   PA     G    D + P    A +   E  + D+A
Sbjct: 1427 GLIRELAAVEDELYQRMLKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQA 1485


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score =  100 bits (248), Expect = 3e-20
 Identities = 186/897 (20%), Positives = 307/897 (34%), Gaps = 106/897 (11%)

Query: 1675 EPATVSEEAKPASEPAPAPVEQLEQVDLPPG--ADPDKEAAMMPAGVEEGSSGDQPP--- 1729
            +P    E  + ++   P P E  E+   PP   ++ D  A+   +G +     ++PP   
Sbjct: 1425 DPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGAT 1484

Query: 1730 -----YLDAKPPTPGASFSQA---ESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATA 1781
                 +  A+P    A  S +    + +D +P     L K  +K+  A+   A       
Sbjct: 1485 MMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRAR 1544

Query: 1782 DAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVT 1841
                D +   + A E Q   ++ L+       +  +    +    P + A    +     
Sbjct: 1545 WGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQ 1604

Query: 1842 RKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRR 1901
            ++  R+   +   + S R      L   +E E    TA  +   +    E   P     R
Sbjct: 1605 QRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVR 1664

Query: 1902 RNVR--SVYATMGDHENRSPVKEPVE-QPRVTRKRLERELQEAAAVPTTPRRGRPPKTRR 1958
            + V   S  ATMG    R P+KE  + Q  + RKR E    EAA V        P  TR 
Sbjct: 1665 KKVSPMSPKATMG--ATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRT 1722

Query: 1959 RADEE-------------EENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPK 2005
                E             +E E  E ++ L      + P+  +       Q ++GK    
Sbjct: 1723 VQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRD---KDPKLGEAEGDAMAQEREGKTH-- 1777

Query: 2006 VDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKD------AGTDKNPPETAP 2059
                   + T  G ++G  E   E  +   E G +      +      AG D++P ++  
Sbjct: 1778 ------NSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDG 1831

Query: 2060 VEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAV 2119
             E +E   A  +      G       A +     +  +    P     +A E E G    
Sbjct: 1832 AEGIEAPEAEGEAQPESEGVE-----APEAEGDAQEAEGEAQPESEDVEAPEAE-GEAQP 1885

Query: 2120 SPEKSESPQKEDGL---SSQLKSDPVDPDKEPEKEDVSA---SGPSPEATQLAKQMELEQ 2173
              E  E+P+ E  +   S   ++   + + +PE E V A    G     ++ A+  E E+
Sbjct: 1886 ESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEE 1945

Query: 2174 AVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENF 2233
            A +      +  +      +A E   PE  D  A +  E E   A G    +   E E+ 
Sbjct: 1946 AAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEV-EVETQEAEG----EAQPESEDV 2000

Query: 2234 PAPPPYPG--ESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPD- 2290
             AP       E++ + QP +     QP  EG E  E      +TE   +     V AP+ 
Sbjct: 2001 EAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEA 2060

Query: 2291 -------------------PSAGPTDTKEARGNSSETSHSV--PEAKGSKEVEVTLVRKD 2329
                               P +   D +EA G +   S  V  PEA+G  +    +   +
Sbjct: 2061 EEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPE 2120

Query: 2330 KGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQ--HPEAPQEEKQS 2387
               +    S        +  A  ES   E+  A+GE+   +EG   Q    EA  E +  
Sbjct: 2121 TEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGV 2180

Query: 2388 EKPHSTPPQSCTSDLSKIPSTENSSQ-EISVEERTPTKASVPPDLPPPPQP-APVDEEPQ 2445
            E P +       S+  + P  E  +Q E+   E    +    P+      P A  + +P+
Sbjct: 2181 EAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPE 2240

Query: 2446 ARFRVHSIIESDPVT--------PPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSP 2494
            +        +  P            S+ S P+P           PP   G  PHQ P
Sbjct: 2241 SEGETQGEKKGSPQVSLGDGQSEEASESSSPVP-----EDRPTPPPSPGGDTPHQRP 2292



 Score = 84.0 bits (206), Expect = 3e-15
 Identities = 138/662 (20%), Positives = 238/662 (35%), Gaps = 74/662 (11%)

Query: 1498 KKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDS---- 1553
            +++  D + K+ + + D   +E+E +   +     S + E + +     ER E       
Sbjct: 1750 QRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSG 1809

Query: 1554 --DFISGRIY-GKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQ 1610
              D + G    G     G +   + I+ P     ++  E   ++  E E D +  E E Q
Sbjct: 1810 HEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ-PESEGVEAPEAEGDAQEAEGEAQ 1868

Query: 1611 ---EDTENHPKTPESAPENKDSELKTPPS---VGPPSVTVVTLESAPSALEKTTGDKTVE 1664
               ED E      E+ PE++D E  TP +   V P S      E+   A  +T   + +E
Sbjct: 1869 PESEDVEAPEAEGEAQPESEDVE--TPEAEWEVQPESEGAEAPEAEKEAQPETESVEALE 1926

Query: 1665 A-----PLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGV 1719
                  P     +  E    ++EA+  ++P    +E  E  +       D EA  +    
Sbjct: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986

Query: 1720 EEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDA 1779
            +E     QP   D + P       +AE    PE D  +  ++P  + EEA E + E    
Sbjct: 1987 QEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVE--AQPKSEGEEAQEVEGETQKT 2044

Query: 1780 TADAEPDAN--QKAEAAPESQPPASE--DLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSI 1835
              DA+P+++  +  EA  E+Q    E  + E +    ++D    +++    P      + 
Sbjct: 2045 EGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAP 2104

Query: 1836 VEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLP 1895
              +   +K+E I+  + +    P  E  +  E + EA+  +       A     PE    
Sbjct: 2105 EAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPE---- 2160

Query: 1896 LSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPK 1955
                    + +  A     E   P  E VE P            E  A P +     P  
Sbjct: 2161 -----SEGIEAQEA----EEEAQPELEGVEAPEA----------EGEAQPESEGIEAPEA 2201

Query: 1956 TRRRADEEEENEAKEPAETLKP-PEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEAT 2014
                  E E  EA E  E  +P PEG  +P ++            G+ +P+ +    +  
Sbjct: 2202 EGEAQPELEGVEAPEAEEEAQPEPEGVETPEAE------------GEAQPESEG-ETQGE 2248

Query: 2015 TEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSK 2074
             +  PQ+ + +   E  +   E+ S    DR        PP +   +   ++P  +    
Sbjct: 2249 KKGSPQVSLGDGQSEEAS---ESSSPVPEDR------PTPPPSPGGDTPHQRPGSQTGPS 2299

Query: 2075 SKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLS 2134
            S R  S  +    D        D   SP   +      E     + PE S S Q+E  L 
Sbjct: 2300 SSRASSWGNCWQKDSENDHVLGDTR-SPDAKSTGTPHAERKATRMYPESSTSEQEEAPLG 2358

Query: 2135 SQ 2136
            S+
Sbjct: 2359 SR 2360



 Score = 83.2 bits (204), Expect = 4e-15
 Identities = 142/654 (21%), Positives = 229/654 (35%), Gaps = 110/654 (16%)

Query: 1720 EEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDA 1779
            E  + GDQ P         G    +AE    PE +             EA E + +  +A
Sbjct: 1817 EAAAGGDQDP--GQSDGAEGIEAPEAEGEAQPESEGV-----------EAPEAEGDAQEA 1863

Query: 1780 TADAEPDAN--QKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVE 1837
              +A+P++   +  EA  E+QP  SED+E   P A  + +P          +  A     
Sbjct: 1864 EGEAQPESEDVEAPEAEGEAQPE-SEDVET--PEAEWEVQPESEGAEAPEAEKEA----- 1915

Query: 1838 KPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLS 1897
            +P T   E ++ E      S   EAQ+  E   EAE  T+  S+                
Sbjct: 1916 QPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESE---------------- 1959

Query: 1898 RTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTR 1957
                     V  +    E   P  E VE   V    +E +  E  A P +     P    
Sbjct: 1960 ---------VIESQEAEEEAQPESEDVEALEV---EVETQEAEGEAQPESEDVEAPEAEG 2007

Query: 1958 RRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATR-PEATTE 2016
               + EEE + +      +P    +S   +     G  Q  +G  +P+ D    PEA  E
Sbjct: 2008 EMQEAEEEAQPESDGVEAQP----KSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEE 2063

Query: 2017 VGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSK 2076
                   +E+  E + AE EA  E +         +  PE+  VE      APE   +++
Sbjct: 2064 A------QEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVE------APEAEGEAQ 2111

Query: 2077 RGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQ 2136
            +        A +     +     +    A  +A     GV A   E    P+ E      
Sbjct: 2112 KAEGIE---APETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEG----- 2163

Query: 2137 LKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPE 2196
            +++   + + +PE E V A     EA   ++ +E            EA   A  + +  E
Sbjct: 2164 IEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAP----------EAEGEAQPELEGVE 2213

Query: 2197 GLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQ-PPAGAQA 2255
                E+  +P  +  ET  A           GE     A P   GE+Q + +  P  +  
Sbjct: 2214 APEAEEEAQPEPEGVETPEA----------EGE-----AQPESEGETQGEKKGSPQVSLG 2258

Query: 2256 LQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEAR-GN----SSETSH 2310
               SEE  E+   V     T   +     P   P    GP+ ++ +  GN     SE  H
Sbjct: 2259 DGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDH 2318

Query: 2311 SVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQG 2364
             + + +     +          +K TR   + +T+++  AP+ S  PE   ++G
Sbjct: 2319 VLGDTRSP---DAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEG 2369



 Score = 46.6 bits (109), Expect = 5e-04
 Identities = 93/448 (20%), Positives = 179/448 (39%), Gaps = 53/448 (11%)

Query: 670  ESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIERSQSPV 729
            ES   + P    + + +  + +  E  +  +      E  E++++   E   +E  ++  
Sbjct: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEG 1929

Query: 730  HLRRPQSPGASPSQAERLPSDSERRLYSRSSD-RSGSCSSLSPPRYEKLDKSRLERYTKN 788
                P+S GA   +AE    ++E +    S    S      + P  E ++   +E  T+ 
Sbjct: 1930 E-DEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQE 1988

Query: 789  EKTDKE-RTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQS 847
             + + +  + D E  E E  +   E+  + ++D  + + K  S   ++ E + E ++ + 
Sbjct: 1989 AEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK--SEGEEAQEVEGETQKTEG 2046

Query: 848  PEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDT 907
              +P S    + E  ++   A+             V+E EG+   H   E + A+     
Sbjct: 2047 DAQPESDGVEAPEAEEEAQEAEGE-----------VQEAEGEA--HPESEDVDAQ----E 2089

Query: 908  VKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGL----SSHVEVVEKEGRLKARKH 963
             +  A  +   V   E A+ +  K E +  + P+ +G     S  +E  E EG  +    
Sbjct: 2090 AEGEAQPESEGVEAPE-AEGEAQKAEGI--EAPETEGEAQPESEGIEAPEAEGEAQPESE 2146

Query: 964  LKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVK-KSSPEMEDARVLSKKQPDV 1022
                Q A+G +  + E +EA++          E+ +PE++   +PE E      + QP+ 
Sbjct: 2147 GVEAQDAEGEAQPESEGIEAQEAE--------EEAQPELEGVEAPEAE-----GEAQPE- 2192

Query: 1023 SSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVG--SGSRP 1080
               E I   E E E +P  + +   E+++        V +P+   E    S G   G + 
Sbjct: 2193 --SEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK 2250

Query: 1081 SSDLQARLGELAGESVENQEVQSKKPIP 1108
             S  Q  LG+  G+S E  E  S  P+P
Sbjct: 2251 GSP-QVSLGD--GQSEEASE--SSSPVP 2273



 Score = 39.7 bits (91), Expect = 0.056
 Identities = 82/364 (22%), Positives = 118/364 (32%), Gaps = 52/364 (14%)

Query: 1878 TASKNSAADL-----EHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRK 1932
            + SK+ AA L     + P+PS PL     R  +        H    P  +P ++ +  R 
Sbjct: 783  SCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQ--RG 840

Query: 1933 RLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAG 1992
                          TP RGRP   RR +                   G      Q TA G
Sbjct: 841  PSPEASWLCGRYCPTPPRGRPCPQRRSSSC-----------------GSTGSSHQSTARG 883

Query: 1993 GGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDK 2052
             G   ++G  +P         T   GP  G    S   + A     SE+K  R   G   
Sbjct: 884  PGGSPQEGTRQPG-------PTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSGGG--- 933

Query: 2053 NPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGER 2112
             P        V     P     S     R     + +   L   + A    GAA   G  
Sbjct: 934  -PQGQEEASGVSPSSLPR---SSPEAVVREWLDNIPEEPILMTYELADETTGAA--GGGL 987

Query: 2113 ESGVVAVSPEKSESPQKEDGLSSQ--LKSDPVDPDKEPEKEDVSASGPSPEATQLAKQME 2170
                V    + S     E   + Q  L+ DP   D EPE   + +S   P++ +   Q  
Sbjct: 988  RGPEVDPGDDHSLEGLGEPAQAGQQSLEGDP-GQDPEPEGALLGSSDTGPQSGEGVPQGA 1046

Query: 2171 LEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEP 2230
              + V      +EA A A    +AP G     R  P   ++ T++  A   ++    G P
Sbjct: 1047 APEGV------SEAPAEAGADREAPAGCRVSLRALPGRVSASTQIMRA---LMGSKQGRP 1097

Query: 2231 ENFP 2234
             + P
Sbjct: 1098 SSVP 1101



 Score = 37.7 bits (86), Expect = 0.21
 Identities = 90/427 (21%), Positives = 150/427 (35%), Gaps = 49/427 (11%)

Query: 2180 KLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPY 2239
            + ++ SAS A     PEG  PE    P       + A+    I      E +   +    
Sbjct: 447  RCSQDSASPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQI----GAERKAGGSLGED 502

Query: 2240 PGE--SQTDLQPPAGAQALQP---SEEGMETDEAVSGILETEAATESSRPPVNAPDPSAG 2294
            PG       L  P     L P   SEEG  +D + S     E ++E    P   P  +  
Sbjct: 503  PGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSAS-TGSHEGSSEWGGRPQGCPGKARA 561

Query: 2295 PTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVA-PVE 2353
             T  +EA       S ++          ++ +R D  + +T     ++ T   V   P+ 
Sbjct: 562  ETSQQEASEGGDPASPAL---------SLSSLRSDDLQAETQGQGTEQATGAAVTREPLV 612

Query: 2354 SHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKI-PSTENSS 2412
              +  S  ++G S   +  T+ Q  +     + S     + P      L ++ P      
Sbjct: 613  LGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSPSSP-----GLGRVAPRGHPRH 667

Query: 2413 QEISVEERTPTKASVPPDLPPPPQPAPVDEEPQA-RFRVHSIIE----SDPVTPPSDPSI 2467
                 +  +P  +SV   +P PP+     ++    R+   S       S  + PPS  S+
Sbjct: 668  SHYRKDTHSPLDSSVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSL 727

Query: 2468 PIPTLPSVTAAKLSPPV----ASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPA-LPPDT 2522
            P   L   ++A ++P V     SG  PH +P      W           T SPA +PP T
Sbjct: 728  PSQDLLGTSSATVTPAVHSDFVSGVSPHNAPS---AGW----AGDAGSRTCSPAPIPPHT 780

Query: 2523 KASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPL 2582
              S   + +++L +   D      T   S+ +   +  P   A   H +        +P 
Sbjct: 781  SDSCSKSGAASLGEEARD------TPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPA 834

Query: 2583 EEKTAPP 2589
            +E    P
Sbjct: 835  QEAQRGP 841



 Score = 37.0 bits (84), Expect = 0.36
 Identities = 27/91 (29%), Positives = 40/91 (43%), Gaps = 12/91 (13%)

Query: 3341 AQGPPPEGEPLQPPQPVQSTQPAQP---APPCPPSQLGQPGQPP---SSKMPQVSQEAKG 3394
            ++   P+G+  Q   PVQ  +  +    A PCP     +P +PP   S   P  S+   G
Sbjct: 1411 SEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSG 1470

Query: 3395 TQ--TGVEQPRLPAGPANRPPEPHTQVQRAQ 3423
            +Q   G+E+P      A    + HTQ Q  Q
Sbjct: 1471 SQLEPGLEKP----PGATMMGQEHTQAQPTQ 1497



 Score = 35.8 bits (81), Expect = 0.80
 Identities = 87/448 (19%), Positives = 149/448 (33%), Gaps = 66/448 (14%)

Query: 3059 AAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTL--PSITYSIRPEA 3116
            A GI  P+      PE   +  P +          ++GE +  +  +  P      +PE+
Sbjct: 1832 AEGIEAPEAEGEAQPESEGVEAPEAEGDAQE----AEGEAQPESEDVEAPEAEGEAQPES 1887

Query: 3117 --LHSPRAP--LQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAP 3172
              + +P A   +QP+     AP+     QP    V AL ++   E       P +     
Sbjct: 1888 EDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDE-------PESEGAEA 1940

Query: 3173 VQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKE 3232
             ++E    ++E +  P                  SE   + +   +  P S+  +    E
Sbjct: 1941 QEAEEAAQEAEGQTQP-----------------ESEVIESQEAEEEAQPESEDVEALEVE 1983

Query: 3233 AAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHG 3292
              +T +A+    P    V         AP   GE +        +  G+   P    + G
Sbjct: 1984 -VETQEAEGEAQPESEDV--------EAPEAEGEMQEAEEEAQPESDGVEAQPK---SEG 2031

Query: 3293 VQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQ 3352
             +     GE   +   GD +      +    +  A  + G     +  A    PE E + 
Sbjct: 2032 EEAQEVEGE--TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAH---PESEDVD 2086

Query: 3353 PPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRP 3412
              +     QP       P ++ G+  +    + P+   EA+    G+E P   A    +P
Sbjct: 2087 AQEAEGEAQPESEGVEAPEAE-GEAQKAEGIEAPETEGEAQPESEGIEAPE--AEGEAQP 2143

Query: 3413 PEPHTQVQRAQAETGPTS---FPSPVSVSMKPDLP-VSLPTQTAPKQP----LFVPTTSG 3464
                 + Q A+ E  P S            +P+L  V  P      QP    +  P   G
Sbjct: 2144 ESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEG 2203

Query: 3465 PSTP--PGLVLPHT--EFQPAPKQDSSP 3488
             + P   G+  P    E QP P+   +P
Sbjct: 2204 EAQPELEGVEAPEAEEEAQPEPEGVETP 2231



 Score = 33.1 bits (74), Expect = 5.2
 Identities = 34/157 (21%), Positives = 57/157 (36%), Gaps = 12/157 (7%)

Query: 3115 EALHSPRAPLQPQQIE-VRAPQRASTPQPAPAGV--PALASQHPPEEEVHYHLPVARATA 3171
            E + +P A  + Q+ E + AP+     QP   G+  P    +  PE E            
Sbjct: 2099 EGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQ 2158

Query: 3172 PVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGK 3231
            P    +   ++E    P     ++  +  P   A  E    ++G+    P ++   QP  
Sbjct: 2159 PESEGIEAQEAEEEAQP-----ELEGVEAPE--AEGEAQPESEGIEA--PEAEGEAQPEL 2209

Query: 3232 EAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEAR 3268
            E  + P+A+    P P  V  P       P   GE +
Sbjct: 2210 EGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQ 2246


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 99.0 bits (245), Expect = 8e-20
 Identities = 213/931 (22%), Positives = 310/931 (33%), Gaps = 162/931 (17%)

Query: 2642 PAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLT 2701
            P PQ L   +          L+P +   GPV      L  L         VL  P+ VL+
Sbjct: 1040 PVPQVLPASLMVSASPAGPPLIPASRPPGPV-----LLPPLQPNSGSLPQVLPSPLGVLS 1094

Query: 2702 GPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAV---TVTAGAVTAASGGVTATTG 2758
            G     + P   T+      P  V  + +    ++S +   TV  G     +   T +T 
Sbjct: 1095 GT----SRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTT 1150

Query: 2759 TVTMAGAVIAPSTKCKQRA--SANENSRFHPGSMPVIDD------RP-ADAGSGAGLRVN 2809
            T T     +   T   QR   S +  +R   G +  I        RP A+AG    L   
Sbjct: 1151 TATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQ 1210

Query: 2810 TSEGVVLLSYSGQKTEG---PQRISAKISQIPPASAMDIEFQQSVSKSQVK--------- 2857
                 + L+ +  +      P+ +   +  +  A        Q    + ++         
Sbjct: 1211 IQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPT 1270

Query: 2858 PDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHL 2917
            P SV  S  PS  P AP G +     + +  T         I   +A R  L  P P   
Sbjct: 1271 PVSVLPSSTPSTTP-APTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLT-PVPPLA 1328

Query: 2918 SVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPAN 2977
                P + G     L   +N  P L   +L  TP++ T    +  P  ++   K++   +
Sbjct: 1329 PAPRPPSSG-----LPAVLNPRPTLTPGRLP-TPTLGTARAPMPTPTLVRPLLKLVHSPS 1382

Query: 2978 LGSTLTPHHPPALPSKLPTEVN---HVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPS 3034
                  P    + P   P  ++   HVPS  S+P              A SP P    P+
Sbjct: 1383 ------PEVSASAPGAAPLTISSPLHVPS--SLPGP------------ASSPMPI---PN 1419

Query: 3035 SFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLS 3094
            S P AS  SST S  LS++  + +   +P P          + +  P S   TVS S   
Sbjct: 1420 SSPLASPVSSTVSVPLSSSLPISVPTTLPAPA--------SAPLTIPISAPLTVSAS--- 1468

Query: 3095 QGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQH 3154
                      L S+T  + P     P AP  P      A   AS      A  P+L+S  
Sbjct: 1469 ------GPALLTSVTPPLAPVV---PAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQ 1519

Query: 3155 PPEEEV-----HYHLPVARAT-APVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSE 3208
             P   +       H+P   +T AP  S VLV  S               +  P  +A + 
Sbjct: 1520 TPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASA--------------LASPFPSAPNP 1565

Query: 3209 QPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAP---HG 3265
             P  A  +     AS+A   P    A    A  AP+P P   P+PV  P+P  AP     
Sbjct: 1566 APAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASS 1625

Query: 3266 EARILTVTPSN-------QLQGLPLTPPVVVTHGVQIV---------------------- 3296
            +  +  + PS+           +P   PV+     Q +                      
Sbjct: 1626 QTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAP 1685

Query: 3297 -----HSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPL 3351
                        Q    G      P    T +  PA+S V  P++T + A GPP      
Sbjct: 1686 ALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQT 1745

Query: 3352 QPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPAN- 3410
                P     PA P  P P   L     P SS    ++  +  T T    P    GPA  
Sbjct: 1746 LSLAPAPPLAPASPVGPAPAHTLTL--APASSSASLLAPASVQTLTLSPAPVPTLGPAAA 1803

Query: 3411 -----RPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGP 3465
                  P    +   +A +     S  +P+ V+M   LPVS        +P  +   SGP
Sbjct: 1804 QTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVS------KDEPDTLTLRSGP 1857

Query: 3466 STPPGLVL----PHTEFQPAPKQDSSPHLTS 3492
             +PP        P    QP P   S  +L S
Sbjct: 1858 PSPPSTATSFGGPRPRRQPPPPPRSPFYLDS 1888



 Score = 96.3 bits (238), Expect = 5e-19
 Identities = 218/989 (22%), Positives = 337/989 (34%), Gaps = 159/989 (16%)

Query: 2422 PTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLS 2481
            P +    P+L   P P PV +   A   V +     P+ P S P  P+          L 
Sbjct: 1023 PVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPV----------LL 1072

Query: 2482 PPVA--SGGIPHQSP-PTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKIL 2538
            PP+   SG +P   P P  V    +R   P     P+P  P     +    SSS L+ + 
Sbjct: 1073 PPLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLT 1132

Query: 2539 MDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQA 2598
            + P Y    +  +T+ TT      +A P      P P   +  L       + +   +  
Sbjct: 1133 VPPGYTFPPAAATTTSTTTATATTTAVPA-----PTPAPQRLILSPDMQARLPSGEVVSI 1187

Query: 2599 SEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAP--QTLTGLVSALTG 2656
             ++   A +       +  +T  I    +++     +++ + +P P  + +  LVSA  G
Sbjct: 1188 GQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSA-GG 1246

Query: 2657 LVNVSLVPVNALKGPVKGSVTTLKSLVSTPA-GPVNVLKGPVNVLTGPVNVLTTPVNATV 2715
              ++   P +         V  ++++  TP   PV+VL       T     L+ P+ A  
Sbjct: 1247 QHHLISQPAH---------VALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAA-- 1295

Query: 2716 GTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQ 2775
               N  P T+      VN T     V      A   G+T       +A A   PS+    
Sbjct: 1296 ---NQVPPTM------VNNTGVVKIVVR---QAPRDGLTPVP---PLAPAPRPPSSGLP- 1339

Query: 2776 RASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKIS 2835
             A  N      PG +P     P    + A +   T    +L        E    +SA   
Sbjct: 1340 -AVLNPRPTLTPGRLPT----PTLGTARAPMPTPTLVRPLLKLVHSPSPE----VSA--- 1387

Query: 2836 QIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAP-AGYANVATHSTLVLTAQTYN 2894
              P A+ + I     V  S   P S     P S    +P +   +V   S+L ++  T  
Sbjct: 1388 SAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTL 1447

Query: 2895 ASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIV 2954
             +P  +             P+ + +S P+T   +   L   +  P   V       PS+ 
Sbjct: 1448 PAPASA-------------PLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLA 1494

Query: 2955 TTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVS 3014
             +    A P    +   +    +L S+ TP HP  L    PT  +HVP   S  A     
Sbjct: 1495 PSG---ASPSASALTLGLATAPSLSSSQTPGHPLLL---APTS-SHVPGLNSTVAPACSP 1547

Query: 3015 HLAAAKLDAHSPRPSGPGPSSFPRA-SHPSSTASTALSTNATVMLA--AGIPVPQFISSI 3071
             L  A   A SP PS P P+    +   P+S+AS AL+T    M A    I  P     +
Sbjct: 1548 VLVPASALA-SPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPL 1606

Query: 3072 HPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEV 3131
             P   +   P +     S    SQ  V +  P+    T       + +P   L P   + 
Sbjct: 1607 APLPVLAPSPGAAPVLAS----SQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQT 1662

Query: 3132 RAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPV-----QSEVLVMQSEYRL 3186
              P    +P P+PA    LA              +A A AP       S+ L + +    
Sbjct: 1663 MLPAPVPSPLPSPASTQTLA--------------LAPALAPTLGGSSPSQTLSLGTGNPQ 1708

Query: 3187 HPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPT 3246
             P+                           + + PAS     P +  +  P     PT T
Sbjct: 1709 GPFPTQ-----------------------TLSLTPASSLVPTPAQTLSLAPGPPLGPTQT 1745

Query: 3247 PAPVPVPVPLPAPAPAPHGEARILTVTPSN---------QLQGLPLTPPVVVTHGVQIVH 3297
             +  P P PL   +P     A  LT+ P++          +Q L L+P  V T G     
Sbjct: 1746 LSLAPAP-PLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAA- 1803

Query: 3298 SSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPV 3357
                  Q        T  P +Q +     A+ +  LP      ++ P  + EP       
Sbjct: 1804 ------QTLALAPASTQSPASQASSLVVSASGAAPLP--VTMVSRLPVSKDEP------- 1848

Query: 3358 QSTQPAQPAPPCPPSQLGQPGQPPSSKMP 3386
              T   +  PP PPS     G P   + P
Sbjct: 1849 -DTLTLRSGPPSPPSTATSFGGPRPRRQP 1876



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 190/908 (20%), Positives = 304/908 (33%), Gaps = 100/908 (11%)

Query: 2141 PVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPE-GLA 2199
            PV P   PE       GP P+    +  +    A   +   +            P  G  
Sbjct: 1023 PVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSL 1082

Query: 2200 PEDRDKPAHQASETELAAAIGSIINDISGEPENF-PAPPPYPGESQTDLQPPAGAQALQP 2258
            P+    P    S T         +      P    PAPPP        L  P G      
Sbjct: 1083 PQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPA 1142

Query: 2259 SEEGMETDEAVSGILETEAATESSRPPVNAPDPSAG-PTDTKEARGN-SSETSHSVPEAK 2316
            +     T  A +      A T + +  + +PD  A  P+    + G  +S     V  A 
Sbjct: 1143 AATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAG 1202

Query: 2317 GSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQ 2376
            GSK +   +    +G + T    + R        P++ +V     A G+    ++   V 
Sbjct: 1203 GSKPLTFQI----QGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVA 1258

Query: 2377 HPEA----PQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASV---PP 2429
              +A    P     S  P STP  +       +P   N      V      K  V   P 
Sbjct: 1259 LIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPR 1318

Query: 2430 D-LPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSP------ 2482
            D L P P  AP    P +   + +++   P   P    +P PTL +  A   +P      
Sbjct: 1319 DGLTPVPPLAPAPRPPSS--GLPAVLNPRPTLTPG--RLPTPTLGTARAPMPTPTLVRPL 1374

Query: 2483 --------PVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTL 2534
                    P  S   P  +P T  +        P   S+P P       AS V ++ S  
Sbjct: 1375 LKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVS-- 1432

Query: 2535 RKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKP-LEEKTAPPVTNN 2593
                     V  +S    SV T +  P SA   +  + P  V +  P L     PP+   
Sbjct: 1433 ---------VPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPL--- 1480

Query: 2594 SEIQASEVLVAADKEKVAPV-IAPKITSVISRMPVSIDLENSQ---KITLAKPAPQTLTG 2649
                A  V  A     +AP   +P  +++   +  +  L +SQ      L  P    + G
Sbjct: 1481 ----APVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPG 1536

Query: 2650 LVSALTGLVNVSLVPVNALKGPVKGS---VTTLKSLVSTPAGPVNVLKGPVNVLTGPVNV 2706
            L S +    +  LVP +AL  P   +        SL++  +     L  P+  +  P   
Sbjct: 1537 LNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTA 1596

Query: 2707 LTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAV 2766
            +  P  A    +   P    +  +A    +S   V   A ++  G   A+   V     V
Sbjct: 1597 ILAPSPAP--PLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPV 1654

Query: 2767 IAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEG 2826
            +APS+      +   +    P S   +   PA A +  G     S     LS      +G
Sbjct: 1655 LAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGG-----SSPSQTLSLGTGNPQG 1709

Query: 2827 PQRISAKISQIPPASAMDIEFQQSVSKSQVKP--DSVTASQPPSKGPQAPAGYANVATHS 2884
            P     +   + PAS++     Q++S +   P   + T S  P+  P APA     A   
Sbjct: 1710 P--FPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAP-PLAPASPVGPAPAH 1766

Query: 2885 TLVLTAQTYNASPVISSVKADRPSLEKPEPI--------------HLSVSTPVTQGGTVK 2930
            TL L   + +AS +++       +L  P P+                S  +P +Q  ++ 
Sbjct: 1767 TLTLAPASSSAS-LLAPASVQTLTL-SPAPVPTLGPAAAQTLALAPASTQSPASQASSLV 1824

Query: 2931 VLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTL---TPHHP 2987
            V   G    PV + ++L ++           +P TL + +    P +  ++     P   
Sbjct: 1825 VSASGAAPLPVTMVSRLPVSKD---------EPDTLTLRSGPPSPPSTATSFGGPRPRRQ 1875

Query: 2988 PALPSKLP 2995
            P  P + P
Sbjct: 1876 PPPPPRSP 1883



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 102/404 (25%), Positives = 152/404 (37%), Gaps = 73/404 (18%)

Query: 1620 PESAPENKDSELKTPPS---VGPPSVTV-VTLESAPSAL--EKTTGDKTVEAPLVTEEKT 1673
            P   P    + L TP S   +GPPSV +  ++ + P  L  E     + + +P   E  +
Sbjct: 2509 PAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELAS 2568

Query: 1674 VEPA-TVSEEAKPASEPAPAPVEQL----EQVDLPPGADP-DKEAAMMPAGVE-EGSSGD 1726
            V  + T S    P  +  P  VE L    + + L P A     EA  +P G E E     
Sbjct: 2569 VASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSA 2628

Query: 1727 QPPYLDAKPPTPGASFSQAESN---VDPEPDSTQPLSKPAQK---SEEANEPKA-----E 1775
            +   L   P         +ESN   + P   S +PL +P +    SEE  E K      E
Sbjct: 2629 EGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPE 2688

Query: 1776 KPDATADAE---PDANQKAEAAPESQPPA-------SEDLEVDPPVAAKDKKPNKSKRSK 1825
            KP     AE   P  +  A ++PE   PA       S D+E+      +  +P   K  +
Sbjct: 2689 KPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLR 2748

Query: 1826 TPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAA 1885
              +    V++VE          ++E ++R    RG A  L+    E    + +    S  
Sbjct: 2749 K-LPGRLVTVVE----------EKELVRRRRQQRGAASTLVPGVSET---SASPGSPSVR 2794

Query: 1886 DLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLER--------E 1937
             +  PE S P+         S   T            P +QP + R+ +E         E
Sbjct: 2795 SMSGPESSPPIGGPCEAAPSSSLPT------------PPQQPFIARRHIELGVTGGGSPE 2842

Query: 1938 LQEAAAVPTTP-----RRGRPPKTRRRADEEEENEAKEPAETLK 1976
              + A +  TP     RRGRPPK  R   +      + P+ TLK
Sbjct: 2843 NGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPSSTLK 2886



 Score = 50.8 bits (120), Expect = 2e-05
 Identities = 163/844 (19%), Positives = 276/844 (32%), Gaps = 110/844 (13%)

Query: 1579 PVVLFHSRFMELTRMQQKEKEKDQKPKEVEK-QEDTENHPKTPESAPENKDSELKTPPSV 1637
            P+  +  +F+E +  +   +E  Q  ++VE  ++D +   +     P+ ++         
Sbjct: 2311 PIERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEE-------- 2362

Query: 1638 GPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQL 1697
            GP +    +  +      ++   K  E P     + +  A    E + A+        Q 
Sbjct: 2363 GPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLRGARA--ETQGANHTPVISAHQT 2420

Query: 1698 EQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTP-GASFSQAESN-------- 1748
                 PP   P +E    PA     +    P  + A  P P  A    +  N        
Sbjct: 2421 RSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVH 2480

Query: 1749 ---VDPEPDSTQPLSKPAQKSEEA-NEPKAEKPDATADAEPDANQKAEAAPESQPPASED 1804
                 P P    P S PA     A   P A  P          +      P S P ++  
Sbjct: 2481 ILPSPPPPSQIPPCSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASV 2540

Query: 1805 LEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQK 1864
              +  P+  + +    ++   +P      S+     +  S    ++ L  +      ++K
Sbjct: 2541 TNL--PLGLRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEK 2598

Query: 1865 LLELKMEAEKITRTA-SKNSAADLEHPEPS-------------LPLSRTRRRNVRSVYAT 1910
             L L   A  +T  A S  +  + E P+ +             LPL  +    +    + 
Sbjct: 2599 NLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSA 2658

Query: 1911 MGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKE 1970
              D     P++EP+E  R +      EL EA    ++P + +   T   A     + A  
Sbjct: 2659 ASD----EPLQEPLEADRTS-----EELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATS 2709

Query: 1971 PAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNE-PKVDATRP-EATTEVGPQIGVKE--- 2025
              E   P    R   S      G   G+ G+   PKV    P    T V  +  V+    
Sbjct: 2710 SPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQ 2769

Query: 2026 -----SSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRS 2080
                 S++ P  +E  A       R  +G + +PP   P E       P    +    R 
Sbjct: 2770 QRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIAR- 2828

Query: 2081 RNSRLAVDKSASLKNVDA---AVSPRGAAAQAGERESGVVAVSPEKSESPQK-----EDG 2132
            R+  L V    S +N D    A++P     + G          P+K+ SP       ++ 
Sbjct: 2829 RHIELGVTGGGSPENGDGALLAITPPAVKRRRGR--------PPKKNRSPADAGRGVDEA 2880

Query: 2133 LSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKA 2192
             SS LK      D  P  E +  + P  E   +     L     H       +   +   
Sbjct: 2881 PSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVH-----RPNPLLSPVE 2935

Query: 2193 DAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAG 2252
                G  P+ RD P             G+I +   G  E+   PPP+P    T L P   
Sbjct: 2936 KRRRGRPPKARDLPIP-----------GTISSAGDGNSESRTQPPPHP-SPLTPLPP--- 2980

Query: 2253 AQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSV 2312
               + P+     T   V+ I  +    +  RPP N P P        +    S   S  +
Sbjct: 2981 -LLVCPTATVANTVTTVT-ISTSPPKRKRGRPPKNPPSPRPSQLPVLDRDSTSVLESCGL 3038

Query: 2313 -----PEAKGSKEVEVT-------LVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESN 2360
                 P+ +G  E   +       L R  + R +    R +++    VVA ++  +  ++
Sbjct: 3039 GRRRQPQGQGESEGSSSDEDGSRPLTRLARLRLEAEGMRGRKSGGSMVVAVIQDDLDLAD 3098

Query: 2361 QAQG 2364
               G
Sbjct: 3099 SGPG 3102



 Score = 46.6 bits (109), Expect = 5e-04
 Identities = 117/471 (24%), Positives = 158/471 (33%), Gaps = 121/471 (25%)

Query: 3117 LHSPRAPLQPQQIEVRAP-----QRASTPQPAPAGVPA--LASQHPPEEEVHYHLPVARA 3169
            +++PRAPL P  + VR P         TP P P  +PA  + S  P    +   +P +R 
Sbjct: 1012 VNNPRAPLGP--VPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPL---IPASRP 1066

Query: 3170 TAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPA----SKA 3225
              PV    L  Q      P  +P  + ++     +  S  P     +   PPA    S A
Sbjct: 1067 PGPVLLPPL--QPNSGSLPQVLPSPLGVL-----SGTSRPPTPTLSLKPTPPAPVRLSPA 1119

Query: 3226 PQQPGKEAAKT---------PDAKAAPTPTPAPVPVPVPLPAPAPAPH------------ 3264
            P        K          P A A  T T         +PAP PAP             
Sbjct: 1120 PPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARL 1179

Query: 3265 --------GEARILTVTP----------SNQLQGLPLT-------------PPVVVTHGV 3293
                    G+   L   P          + Q+QG  LT             P  +  + V
Sbjct: 1180 PSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVV 1239

Query: 3294 QIVHSSGE---LFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEP 3350
             +V + G+   + Q      I+   P      T  P   SV LPS T +    P     P
Sbjct: 1240 HLVSAGGQHHLISQPAHVALIQAVAP------TPGPTPVSV-LPSSTPSTTPAPTGLSLP 1292

Query: 3351 LQ----PPQPVQST---------QPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQT 3397
            L     PP  V +T          P     P PP  L    +PPSS +P V    + T T
Sbjct: 1293 LAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPP--LAPAPRPPSSGLPAVLNP-RPTLT 1349

Query: 3398 GVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSP-VSVSMKPDLPVSLPTQTAPKQP 3456
                P    G A R P P   + R   +      PSP VS S     P+++ +      P
Sbjct: 1350 PGRLPTPTLGTA-RAPMPTPTLVRPLLKL--VHSPSPEVSASAPGAAPLTISS------P 1400

Query: 3457 LFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRPVDMVQLLKKYPI 3507
            L VP++          LP     P P  +SSP  +       V L    PI
Sbjct: 1401 LHVPSS----------LPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPI 1441



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 65/293 (22%), Positives = 92/293 (31%), Gaps = 72/293 (24%)

Query: 3202 HVTAVS-EQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPA 3260
            H   +S  Q R+     +  PA +   +P      TP +  A  P   PVPV  P+P  A
Sbjct: 2411 HTPVISAHQTRSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISA 2470

Query: 3261 PAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQL 3320
            P P      +T+ P + L   P                                 PP+Q+
Sbjct: 2471 PNP------ITILPVHILPSPP---------------------------------PPSQI 2491

Query: 3321 THTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQP--APPCPPSQLGQPG 3378
                 PA +              PP    P   P P  +  PAQ     P  P  LG P 
Sbjct: 2492 PPCSSPACT--------------PP----PACTPPPAHTPPPAQTCLVTPSSPLLLGPPS 2533

Query: 3379 QPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVS 3438
             P       +S        G+         A   PE       A +ET   S   P    
Sbjct: 2534 VP-------ISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLVPP---- 2582

Query: 3439 MKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLT 3491
             K  LPV++      ++ L +  ++   T     +P+ + Q AP       LT
Sbjct: 2583 -KDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLT 2634



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 175/848 (20%), Positives = 282/848 (33%), Gaps = 120/848 (14%)

Query: 2144 PDKEPEKEDVSASGPSPEATQLAKQME-LEQAV-----------------EHIAKLAEAS 2185
            P +EP    V ++    E T  +KQ   LEQA+                 E +A+LAE +
Sbjct: 2213 PLEEPSSSSVPSAPEEEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFN 2272

Query: 2186 ASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSI--------------INDISGEPE 2231
             +  + A   E       +      +E E+AA +  +              + ++S E  
Sbjct: 2273 ENDGFPAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREEL 2332

Query: 2232 NFPAPPPYPGESQTDLQPPAGAQALQPSEEGMET-DEAVSGILETEAATESSRPPVNAPD 2290
                          D       +  Q  EEG    DE+  G   T   T        AP+
Sbjct: 2333 KQAEEQVEAARKDLDQAKEEVFRLPQEEEEGPGAGDESSCG---TGGGTHRRSKKAKAPE 2389

Query: 2291 PSAGPTDTKEARGNSSET---SHSVPEAKGSKEVEVTLVRKDKGRQKTTR-SRRKRNTNK 2346
               G   ++  RG  +ET   +H+   +        T  R    R++  R + R R T  
Sbjct: 2390 -RPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARERVPRPAPRPRPTPA 2448

Query: 2347 KVVAPVESHVPESNQAQGESPAANEGTTVQ-----HPEAPQEEKQSEKPHSTPPQSCTSD 2401
               A + + VP    A     A N  T +       P  P +      P  TPP +CT  
Sbjct: 2449 SAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPACTPP 2508

Query: 2402 LSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPA--PVDEEPQARFRVHSIIESDPV 2459
             +  P     +Q   V   +P     PP +P        P+   P+A     ++   + +
Sbjct: 2509 PAHTPPP---AQTCLVTPSSPLLLG-PPSVPISASVTNLPLGLRPEAELCAQALASPESL 2564

Query: 2460 TPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPA-- 2517
               S  S    +L  V    L P VA   +P       +T        P A S    A  
Sbjct: 2565 ELASVASSETSSLSLVPPKDLLP-VAVEILPVSEKNLSLT--------PSAPSLTLEAGS 2615

Query: 2518 LPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVD 2577
            +P   +    D++  T   +L + + +        S +  +  P SAA    E    P++
Sbjct: 2616 IPNGQEQEAPDSAEGTTLTVLPEGEELPLC----VSESNGLELPPSAAS--DEPLQEPLE 2669

Query: 2578 SKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVIS--------RMPVSI 2629
            + +  EE T      +S  +  E++ A   E  AP  +   TS           R   S 
Sbjct: 2670 ADRTSEELTEAKTPTSSPEKPQELVTA---EVAAPSTSSSATSSPEGPSPARPPRRRTSA 2726

Query: 2630 DLENSQKITLAK---PAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVS-T 2685
            D+E   + T      P P+ L  L   L  +V      +   +   +G+ +TL   VS T
Sbjct: 2727 DVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEK--ELVRRRRQQRGAASTLVPGVSET 2784

Query: 2686 PAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGA 2745
             A P +     V  ++GP +  + P+    G   AAP     ++S               
Sbjct: 2785 SASPGSP---SVRSMSGPES--SPPIG---GPCEAAP-----SSSLPTPPQQPFIARRHI 2831

Query: 2746 VTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAG 2805
                +GG +   G   +  A+  P+ K ++R    + +R    +   +D+ P+    G  
Sbjct: 2832 ELGVTGGGSPENGDGALL-AITPPAVK-RRRGRPPKKNRSPADAGRGVDEAPSSTLKGKT 2889

Query: 2806 LRVNTSEGVVLLSYSGQKTE-----GPQRISAKISQIP--------------PASAMDIE 2846
               +   G   L  +    E     GPQ +  +    P              P  A D+ 
Sbjct: 2890 NGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRGRPPKARDLP 2949

Query: 2847 FQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADR 2906
               ++S +           PP   P  P     V   +T+  T  T   S      K  R
Sbjct: 2950 IPGTISSAGDGNSESRTQPPPHPSPLTPLPPLLVCPTATVANTVTTVTISTSPPKRKRGR 3009

Query: 2907 PSLEKPEP 2914
            P    P P
Sbjct: 3010 PPKNPPSP 3017



 Score = 40.8 bits (94), Expect = 0.025
 Identities = 57/269 (21%), Positives = 98/269 (36%), Gaps = 47/269 (17%)

Query: 1617 PKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEP 1676
            P +P   P + DS+ +  P  G        LE  P     T  +K    P    ++  E 
Sbjct: 347  PSSPSQTPSSHDSDTRDGPEEGAEEEPPQVLEIKPPPSAVTQRNKQPWHP----DEDDEE 402

Query: 1677 ATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPP 1736
             T +EE     E   A  EQLE        D   E + +    E         Y  A  P
Sbjct: 403  FTANEEEAEDEEDTIAAEEQLEGE-----VDHAMELSELAREGELSMEELLQQYAGAYAP 457

Query: 1737 TPGASFSQAESNVD-----------------PEPDSTQPLSKPAQKSEEANEPKAEKPDA 1779
              G+S  + E  VD                 P+ DS+        +SE+  +  +E+ + 
Sbjct: 458  GSGSSEDEDEDEVDANSSDCEPEGPVEAEEPPQEDSSSQSDSVEDRSEDEEDEHSEEEET 517

Query: 1780 TADAEPDANQKAEAA-PESQPPASEDLEVD----PPVAAKDKKPNKS------------- 1821
            +  +  + ++  E+   +SQ  A E+ E D      + A+D++ +++             
Sbjct: 518  SGSSASEESESEESEDAQSQSQADEEEEDDDFGVEYLLARDEEQSEADAGSGPPTPGPTT 577

Query: 1822 ---KRSKTPVQAAAVSIVEKPVTRKSERI 1847
               K+  T + AAA S+  K  T  + ++
Sbjct: 578  LGPKKEITDIAAAAESLQPKGYTLATTQV 606



 Score = 40.4 bits (93), Expect = 0.033
 Identities = 198/972 (20%), Positives = 297/972 (30%), Gaps = 152/972 (15%)

Query: 1617 PKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSA---LEKTTGDKTVEAPLVTEEKT 1673
            P  P+      +  L+  P     +V VV    AP     +    G +    P       
Sbjct: 984  PPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPPGPELSAQPTPGPVPQ 1043

Query: 1674 VEPATVSEEAKPASEP---APAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPY 1730
            V PA++   A PA  P   A  P   +    L P +    +    P GV  G+S    P 
Sbjct: 1044 VLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPT 1103

Query: 1731 LDAKPPTPGASFSQAESNVDP-EPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQ 1789
            L  KP  P      A   + P  P  +  L KP         P A    AT  +   A  
Sbjct: 1104 LSLKPTPP------APVRLSPAPPPGSSSLLKPLTVPPGYTFPPAA---ATTTSTTTATA 1154

Query: 1790 KAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDR 1849
               A P +  PA + L + P + A      +    +        S+ ++PV         
Sbjct: 1155 TTTAVP-APTPAPQRLILSPDMQA------RLPSGEVVSIGQLASLAQRPVANAG----- 1202

Query: 1850 EKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYA 1909
                          K L  +++  K+T T ++     +  P P        +RNV  + +
Sbjct: 1203 ------------GSKPLTFQIQGNKLTLTGAQVRQLAVGQPRP-------LQRNVVHLVS 1243

Query: 1910 TMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAK 1969
              G H         + QP          +Q  A  P        P +           + 
Sbjct: 1244 AGGQH-------HLISQPAHVAL-----IQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSL 1291

Query: 1970 EPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSME 2029
              A    PP    +    K      P+       P   A RP       P  G+  + + 
Sbjct: 1292 PLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRP-------PSSGL-PAVLN 1343

Query: 2030 PKAAEEEAGSEQKRDRKDAGTDKNPPET----APVEVVEKKPAPEKNSKSKRGRSRNSRL 2085
            P+       +  +      GT + P  T     P+  +   P+PE ++ +          
Sbjct: 1344 PRPTL----TPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISS 1399

Query: 2086 AVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPD 2145
             +   +SL    ++  P   ++      S  V+V    S        L +   +    P 
Sbjct: 1400 PLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPI 1459

Query: 2146 KEPEKEDVSASGP----------------SPEATQLAKQMELEQAVEHIAKLAEA-SASA 2188
              P    VSASGP                +P    LA       A      LA A S S+
Sbjct: 1460 SAP--LTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSS 1517

Query: 2189 AYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFP-APPPYPGESQTDL 2247
            +     P  LAP     P   ++   +A A   ++   S     FP AP P P ++    
Sbjct: 1518 SQTPGHPLLLAPTSSHVPGLNST---VAPACSPVLVPASALASPFPSAPNPAPAQASLLA 1574

Query: 2248 QPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSE 2307
               + +QAL      M   +  + IL    A   +  PV AP P A P         SS+
Sbjct: 1575 PASSASQALATPLAPMAAPQ--TAILAPSPAPPLAPLPVLAPSPGAAPVLA------SSQ 1626

Query: 2308 TSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQ---- 2363
            T   VP    S     +L          T      +T   + APV S +P     Q    
Sbjct: 1627 T--PVPVMAPSSTPGTSLASASP-VPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLAL 1683

Query: 2364 ---------GESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQE 2414
                     G SP+        +P+          P  T   S T   S +P+   +   
Sbjct: 1684 APALAPTLGGSSPSQTLSLGTGNPQG---------PFPTQTLSLTPASSLVPTPAQTLSL 1734

Query: 2415 ISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSD------PSIP 2468
                   PT+       PP    +PV   P     +     S  +  P+          P
Sbjct: 1735 APGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAP 1794

Query: 2469 IPTLPSVTAAKLSPPVASGGIPHQS--------------PPTKVTEWITRQEEPRAQSTP 2514
            +PTL    A  L+   AS   P                 P T V+     ++EP   +  
Sbjct: 1795 VPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLR 1854

Query: 2515 S-PALPPDTKAS 2525
            S P  PP T  S
Sbjct: 1855 SGPPSPPSTATS 1866



 Score = 40.4 bits (93), Expect = 0.033
 Identities = 56/271 (20%), Positives = 104/271 (38%), Gaps = 29/271 (10%)

Query: 1565 TSEGANSTT--DSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPES 1622
            ++EG   T   +  + P+ +  S  +EL      + E  Q+P E ++  +     KTP S
Sbjct: 2627 SAEGTTLTVLPEGEELPLCVSESNGLELPPSAASD-EPLQEPLEADRTSEELTEAKTPTS 2685

Query: 1623 APENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEE 1682
            +PE K  EL T     P         ++ SA     G      P       VE       
Sbjct: 2686 SPE-KPQELVTAEVAAP--------STSSSATSSPEGPSPARPPRRRTSADVE-IRGQGT 2735

Query: 1683 AKPASEPAPAPVEQLEQVDLPPG---ADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPG 1739
             +P   P P  + +L      PG      +++  +     + G++    P +     +PG
Sbjct: 2736 GRPGQPPGPKVLRKL------PGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASPG 2789

Query: 1740 ASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQP 1799
            +   ++ S     P+S+ P+  P + +  ++ P   +    A    +       +PE+  
Sbjct: 2790 SPSVRSMSG----PESSPPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGGGSPENGD 2845

Query: 1800 PASEDLEVDPPVAAKDKKPNKSKRSKTPVQA 1830
             A   L + PP A K ++    K++++P  A
Sbjct: 2846 GAL--LAITPP-AVKRRRGRPPKKNRSPADA 2873



 Score = 39.7 bits (91), Expect = 0.056
 Identities = 54/239 (22%), Positives = 76/239 (31%), Gaps = 60/239 (25%)

Query: 3238 DAKAAPTPTPAPVPVPVPLPA---PAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQ 3294
            +   AP P P P PV + +     P P   G   ++   P   L  +P+ PP        
Sbjct: 976  EVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPP-------- 1027

Query: 3295 IVHSSGELFQEYRYGDIRTYHPPAQLTHTQ------FPAASSVG---LPSRTKTAAQGPP 3345
                  EL  +   G +    P + +           PA+   G   LP     +   P 
Sbjct: 1028 ---PGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQ 1084

Query: 3346 PEGEPL-------QPPQPVQSTQPAQPAP----PCPP---SQLGQP-GQPPSSKMPQVSQ 3390
                PL       +PP P  S +P  PAP    P PP   S L +P   PP    P  + 
Sbjct: 1085 VLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAA 1144

Query: 3391 EAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPT 3449
                T T                        A     P   P+P  + + PD+   LP+
Sbjct: 1145 TTTSTTTAT----------------------ATTTAVPAPTPAPQRLILSPDMQARLPS 1181



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 118/648 (18%), Positives = 228/648 (35%), Gaps = 87/648 (13%)

Query: 1664 EAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGS 1723
            + P++  +   +  T S    PAS  +PA            GA       + P  + + S
Sbjct: 11   QLPVLQTQMVSDGMTGSNPVSPASSSSPAS----------SGA-----GGISPQHIAQDS 55

Query: 1724 SGDQPPYLD--AKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATA 1781
            S D PP     A  P  G S SQA    +  P   +  ++ A++++   E +    +   
Sbjct: 56   SLDGPPGPPDGATVPLEGFSLSQAADLANKGPKWEKSHAEIAEQAKHEAEIETRIAELRK 115

Query: 1782 DAEPDANQKAEAAPESQPPASEDLEVDPP--VAAKDKKPNKSKRSKTPVQAAAVSIVEKP 1839
            +      +  +     +P    D   +    ++A   +  + KR           +  K 
Sbjct: 116  EGFWSLKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRG----------VARKV 165

Query: 1840 VTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRT 1899
            V       + ++ K   + R E  KL  +     K  R    N    ++  + S    + 
Sbjct: 166  VRMVIRHHEEQRQKEERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKR 225

Query: 1900 RRRNVRSVYATMGDHENRSPV-KEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRR 1958
            ++     +   +G  E  S +  + + QP  + K        +++  ++P    PP   R
Sbjct: 226  KKALDLHLDFIVGQTEKYSDLLSQSLNQPLTSSKAGSSPCLGSSSAASSP----PPPASR 281

Query: 1959 RADEE-----EENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNE---PKVDATR 2010
              DE+     +E+E ++  ET++  E            G   + ++ + E    + +   
Sbjct: 282  LDDEDGDFQPQEDEEEDDEETIEVEE---------QQEGNDAEAQRREIELLRREGELPL 332

Query: 2011 PEATTEVGPQI--GVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETA-----PVEVV 2063
             E    + PQ+  G    S  P + + +      RD  + G ++ PP+       P  V 
Sbjct: 333  EELLRSLPPQLLEGPSSPSQTPSSHDSDT-----RDGPEEGAEEEPPQVLEIKPPPSAVT 387

Query: 2064 EKKPAPEKNSKSKRGRSRNSRLAVDKSASLK-------NVDAAVSPRGAAAQAG------ 2110
            ++   P    +     + N   A D+  ++         VD A+     A +        
Sbjct: 388  QRNKQPWHPDEDDEEFTANEEEAEDEEDTIAAEEQLEGEVDHAMELSELAREGELSMEEL 447

Query: 2111 -ERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDP--DKEPEKEDVSASGPSPEATQLAK 2167
             ++ +G  A     SE   +++  ++    +P  P   +EP +ED S+   S E     +
Sbjct: 448  LQQYAGAYAPGSGSSEDEDEDEVDANSSDCEPEGPVEAEEPPQEDSSSQSDSVEDRSEDE 507

Query: 2168 QMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDIS 2227
            + E  +  E     A   + +    DA      ++ ++      E  LA        D  
Sbjct: 508  EDEHSEEEETSGSSASEESESEESEDAQSQSQADEEEEDDDFGVEYLLARDEEQSEADAG 567

Query: 2228 GEPENFPAPPPY---PGESQTDLQPPAGAQALQPSEEGMETDEAVSGI 2272
              P   P P P    P +  TD+   A A++LQP    + T +  + I
Sbjct: 568  SGP---PTPGPTTLGPKKEITDI--AAAAESLQPKGYTLATTQVKTPI 610



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 119/594 (20%), Positives = 192/594 (32%), Gaps = 82/594 (13%)

Query: 2881 ATHSTLVLTAQTYNAS-PVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTP 2939
            A H+ ++   QT + + P   S   +R     P P     S P      V V    ++ P
Sbjct: 2409 ANHTPVISAHQTRSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPV---PVSAP 2465

Query: 2940 -PVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEV 2998
             P+   N + + P  +  +      +     +    P    +    H PP   + L T  
Sbjct: 2466 VPISAPNPITILPVHILPSPPPPSQIP-PCSSPACTPPPACTPPPAHTPPPAQTCLVTPS 2524

Query: 2999 NHVPSGP-SIPADRTVSHLAAA-KLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATV 3056
            + +  GP S+P   +V++L    + +A     +   P S   AS  SS  S+        
Sbjct: 2525 SPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLVPPKD 2584

Query: 3057 MLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEA 3116
            +L   + +         E+++ + P + + T+    +  G+ +    +    T ++ PE 
Sbjct: 2585 LLPVAVEILPV-----SEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEG 2639

Query: 3117 LHSPRAPLQPQQIEVRAPQRASTPQPAP------------AGVPALASQHPPEEEVHYHL 3164
               P    +   +E+     +  P   P            A  P  + + P E      L
Sbjct: 2640 EELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQE------L 2693

Query: 3165 PVARATAPVQSEVLVMQSEYRLHPYTVPR---DVRIMVHPHVTAVSEQPRAADGVVKVPP 3221
              A   AP  S       E    P   PR      + +    T    QP     + K+P 
Sbjct: 2694 VTAEVAAPSTSSSATSSPEGP-SPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPG 2752

Query: 3222 -----------ASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARIL 3270
                         +  QQ G  +   P          +P    +  P  +P   G     
Sbjct: 2753 RLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCE-- 2810

Query: 3271 TVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPA--- 3327
               PS+ L   P  P +   H    V   G    E   G +    PPA       P    
Sbjct: 2811 -AAPSSSLPTPPQQPFIARRHIELGVTGGGS--PENGDGALLAITPPAVKRRRGRPPKKN 2867

Query: 3328 ------------ASSVGLPSRTKTAAQGPPPE----GEPLQPPQPVQSTQPAQPAP---P 3368
                        A S  L  +T  A   P PE     +P+  PQ +   QP  P P   P
Sbjct: 2868 RSPADAGRGVDEAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRP 2927

Query: 3369 CP---PSQLGQPGQPPSSK-MP---QVSQEAKGTQTGVEQPRLPAGPANRPPEP 3415
             P   P +  + G+PP ++ +P    +S    G      QP  P  P+   P P
Sbjct: 2928 NPLLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQP--PPHPSPLTPLP 2979



 Score = 37.7 bits (86), Expect = 0.21
 Identities = 87/371 (23%), Positives = 126/371 (33%), Gaps = 105/371 (28%)

Query: 3120 PRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLV 3179
            PR     +++   AP+   TP  APA +PAL             +PV   +APV      
Sbjct: 2427 PRCSPARERVPRPAPRPRPTPASAPAAIPAL-------------VPVP-VSAPV------ 2466

Query: 3180 MQSEYRLHPYTVPRDVRIM-VHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPD 3238
                    P + P  + I+ VH     +   P         PP S+ P          P 
Sbjct: 2467 --------PISAPNPITILPVH-----ILPSP---------PPPSQIP----------PC 2494

Query: 3239 AKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHS 3298
            +  A TP PA  P P   P P       A+   VTPS+ L    L PP      V I  S
Sbjct: 2495 SSPACTPPPACTPPPAHTPPP-------AQTCLVTPSSPLL---LGPP-----SVPISAS 2539

Query: 3299 SGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGL----PSRTKTAAQGPPPEGEPLQPP 3354
               L    R        P A+L      +  S+ L     S T + +  PP +  P+   
Sbjct: 2540 VTNLPLGLR--------PEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPV-AV 2590

Query: 3355 QPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGT-----------------QT 3397
            + +  ++      P  PS   + G  P+ +  +    A+GT                   
Sbjct: 2591 EILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESN 2650

Query: 3398 GVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPL 3457
            G+E P  P+  ++ P +   +  R   E   T   +P S    P+ P  L T        
Sbjct: 2651 GLELP--PSAASDEPLQEPLEADRTSEEL--TEAKTPTS---SPEKPQELVTAEVAAPST 2703

Query: 3458 FVPTTSGPSTP 3468
                TS P  P
Sbjct: 2704 SSSATSSPEGP 2714



 Score = 37.4 bits (85), Expect = 0.28
 Identities = 102/475 (21%), Positives = 155/475 (32%), Gaps = 91/475 (19%)

Query: 2154 SASGPSP-EATQLAKQMELEQAVEH-IAKLAEASASAAYKADAPE-----GLAPEDRDKP 2206
            SA  P+P +A+ LA      QA+   +A +A    +    + AP       LAP     P
Sbjct: 1561 SAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAP 1620

Query: 2207 AHQASETEL-----AAAIGSIINDISGEPEN------------FPAPPPYPGESQTDLQP 2249
               +S+T +     ++  G+ +   S  P               PAP P P  S    Q 
Sbjct: 1621 VLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQT 1680

Query: 2250 PAGAQALQPSEEGMETDEAVS-------GILETEAAT---ESSRPPVN------APDPSA 2293
             A A AL P+  G    + +S       G   T+  +    SS  P        AP P  
Sbjct: 1681 LALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPL 1740

Query: 2294 GPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVE 2353
            GPT T     + +      P +        TL         +  +     T     APV 
Sbjct: 1741 GPTQTL----SLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVP 1796

Query: 2354 SHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQ 2413
            +  P + Q    +PA+ +        A Q            P   T  +S++P +++   
Sbjct: 1797 TLGPAAAQTLALAPASTQS------PASQASSLVVSASGAAPLPVTM-VSRLPVSKDEPD 1849

Query: 2414 EISVEERTPTKASV--------PPDLPPPPQPAPVD----EEPQARFRVHSIIESDPVTP 2461
             +++    P+  S         P   PPPP  +P      EE + R R   +     ++ 
Sbjct: 1850 TLTLRSGPPSPPSTATSFGGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSE 1909

Query: 2462 PSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPD 2521
                  P+     +    L  PVAS   P    P+  T W   +   RA   P   L   
Sbjct: 1910 AHGALAPVYGTEVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAAHRAVLFPQQRL--- 1966

Query: 2522 TKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSA-APCLHEAPPPP 2575
                  D  S  + + +                   +  PV A  P LH   PPP
Sbjct: 1967 ------DQLSEIIERFIF------------------VMPPVEAPPPSLHACHPPP 1997



 Score = 36.6 bits (83), Expect = 0.47
 Identities = 54/236 (22%), Positives = 85/236 (36%), Gaps = 28/236 (11%)

Query: 1586 RFMELTRMQQKEKEK-----DQKPKEVEKQED----TENHPKTPESAPENKDSELKTPPS 1636
            +F + +R+++K K+      D    + EK  D    + N P T   A  +      +  S
Sbjct: 214  QFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQSLNQPLTSSKAGSSPCLGSSSAAS 273

Query: 1637 VGPPSVTVVTLESA---PSALEKTTGDKTVEAPLVTEEKTVEPATVS------EEAKPAS 1687
              PP  + +  E     P   E+   ++T+E     E    E           E   P  
Sbjct: 274  SPPPPASRLDDEDGDFQPQEDEEEDDEETIEVEEQQEGNDAEAQRREIELLRREGELPLE 333

Query: 1688 EPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAES 1747
            E   +   QL +    P   P    +    G EEG+  + P  L+ KPP P A   + + 
Sbjct: 334  ELLRSLPPQLLEGPSSPSQTPSSHDSDTRDGPEEGAEEEPPQVLEIKPP-PSAVTQRNKQ 392

Query: 1748 NVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASE 1803
               P+ D          +   ANE +AE  + T  AE     + + A E    A E
Sbjct: 393  PWHPDED---------DEEFTANEEEAEDEEDTIAAEEQLEGEVDHAMELSELARE 439



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 33/109 (30%), Positives = 42/109 (38%), Gaps = 18/109 (16%)

Query: 3366 APPCPPSQLGQPGQPPSSKMPQVSQEAKG-TQTGVEQPRLPAGPANRPPEPHTQVQRAQA 3424
            AP  PP    +P +   ++M Q   + +G T   V  PR P GP    P P         
Sbjct: 980  APDPPPRP--KPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPP--------- 1028

Query: 3425 ETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVL 3473
              GP     P    +   LP SL    +P  P  +P     S PPG VL
Sbjct: 1029 --GPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPA----SRPPGPVL 1071



 Score = 34.7 bits (78), Expect = 1.8
 Identities = 36/179 (20%), Positives = 68/179 (37%), Gaps = 13/179 (7%)

Query: 2242 ESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEA 2301
            E  +DL   +  Q L  S+ G       S  L + +A  S  PP +  D   G    +E 
Sbjct: 241  EKYSDLLSQSLNQPLTSSKAGS------SPCLGSSSAASSPPPPASRLDDEDGDFQPQED 294

Query: 2302 RGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQ 2361
                 E +  V E +   + E       + R+     R      ++++  +   + E   
Sbjct: 295  EEEDDEETIEVEEQQEGNDAEA------QRREIELLRREGELPLEELLRSLPPQLLEGPS 348

Query: 2362 AQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIP-STENSSQEISVEE 2419
            +  ++P++++  T   PE   EE+  +     PP S  +  +K P   +   +E +  E
Sbjct: 349  SPSQTPSSHDSDTRDGPEEGAEEEPPQVLEIKPPPSAVTQRNKQPWHPDEDDEEFTANE 407


>gi|167736355 mucin 4 isoform a [Homo sapiens]
          Length = 5284

 Score = 97.1 bits (240), Expect = 3e-19
 Identities = 258/1149 (22%), Positives = 396/1149 (34%), Gaps = 145/1149 (12%)

Query: 2403 SKIPSTENSSQEISVEERTPTKASVPPDLPPP-PQPAPVDEEPQARFRVHSIIESDP--V 2459
            + +P T+ SS  IS    TP   + P         P PV +   A     S   ++P  V
Sbjct: 2879 TSLPVTDTSS--ISTGHATPLHVTSPSSASTGHATPLPVTDTSSA-----STGHANPLHV 2931

Query: 2460 TPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALP 2519
            T PS  S    T   VT        AS G     P T ++   T    P   ++PS A  
Sbjct: 2932 TSPSSASTGHATPLPVTDTSS----ASTGHATPLPVTSLSSVSTGDTTPLPVTSPSSAST 2987

Query: 2520 PDTKASDV-DTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDS 2578
              T    V DTSS++  +    P  V++TS  ST  TT +    +++    +A P PV S
Sbjct: 2988 GHTTPLPVTDTSSASTGQATALP--VTSTSSASTGDTTPLPVTDTSSASTGQATPLPVTS 3045

Query: 2579 KKPLE--EKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQK 2636
               +   + T  PVT+ S         +A      P++    +S  +     + + +   
Sbjct: 3046 LSSVSTGDTTPLPVTSPS---------SASTGHATPLLVTDASSASTGQATPLPVTSLSS 3096

Query: 2637 ITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGP 2696
            ++     P  +T   SA TG  + + +PV        G  T+L    ++ A   +    P
Sbjct: 3097 VSTGDTTPLPVTSPSSASTG--HATSLPVTDTSSASTGDTTSLPVTDTSSAYTGDTTSLP 3154

Query: 2697 VNVLTGPVNVLTTPVNAT----VGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGG 2752
            V   +      TTP+  T    V T +A P  V  A+SA    A+ + VT+ + +A++G 
Sbjct: 3155 VTDTSSSSTGDTTPLLVTETSSVSTGHATPLLVTDASSASTGHATPLHVTSPS-SASTGD 3213

Query: 2753 VTAT----TGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRV 2808
             T      T +V+   A   P T     AS  + +R     +PV D   A  G    L V
Sbjct: 3214 TTPVPVTDTSSVSTGHATPLPVTGLSS-ASTGDTTR-----LPVTDISSASTGQATPLPV 3267

Query: 2809 NTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPS 2868
              +  V            P   S        A+ + +    S S     P  VT++   S
Sbjct: 3268 TNTSSVSTGDTMPLPVTSPSSASTG-----HATPLPVTSTSSASTGHATPVPVTSTSSAS 3322

Query: 2869 KGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGT 2928
             G   P    + ++ ST   T       PV S   A   S     P+H+++ +  + G T
Sbjct: 3323 TGHTTPLPVTDTSSASTGDTTPL-----PVTSPSSA---STGHTTPLHVTIPSSASTGDT 3374

Query: 2929 VKVLTQGINTPPVLVHNQLVLTP-SIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHP 2987
              +   G ++        L +T  S V+T      PVT            L  T      
Sbjct: 3375 STLPVTGASSASTGHATPLPVTDTSSVSTGHATPLPVTSLSSVSTGDTTPLPVTDASSAS 3434

Query: 2988 PALPSKLP-TEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTA 3046
                + LP T ++ V +G + P   T         DA S       P      S  S+  
Sbjct: 3435 TGQATPLPVTSLSSVSTGDTTPLLVT---------DASSVSTGHATPLPVTDTSSASTGD 3485

Query: 3047 STALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLP 3106
            +T L    T   + G   P  ++S+    +    P  +T   S+S      + +   +  
Sbjct: 3486 TTRLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLLVTDASSVSTGHATPLPVTDTSSA 3545

Query: 3107 SITYSIR-PEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPE-EEVHYHL 3164
            S   + R P    S  +  Q   + V  P  +S+    P  V + +S        +H   
Sbjct: 3546 STGDTTRLPVTDTSSASTGQATPLPVTIPSSSSSGHTTPLPVTSTSSVSTGHVTPLHVTS 3605

Query: 3165 PVARATAPVQSEVLVMQSEYRLHPYT--VPRDVRIMVHPHVTA--VSEQPRAADGVVKVP 3220
            P + +T  V    +   S       T  +  D   +   H T   V++   A+ G     
Sbjct: 3606 PSSASTGHVTPLPVTSTSSASTGHATPLLVTDASSVSTGHATPLPVTDASSASTGDTTPL 3665

Query: 3221 PASKAPQQPGKEAAKTP------------------DAKAAPTPTPAPVPV---------- 3252
            P +        +A   P                  DA +A T    P+PV          
Sbjct: 3666 PVTDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTDASSASTGHATPLPVTIPSSVSTGD 3725

Query: 3253 --PVPLPAPAPAPHGEARILTVTPSNQLQGLPLTP-PVVVTHGVQIVHSSGELFQEYRYG 3309
              P+P+ +P+ A  G A  L VT  +       TP PV  T      H++          
Sbjct: 3726 TMPLPVTSPSSASTGHATPLPVTGLSSASTGDTTPLPVTDTSSASTRHAT---------- 3775

Query: 3310 DIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAP-- 3367
                   P  +T T     SS      T+               P PV ST  A      
Sbjct: 3776 -------PLPVTDT-----SSASTDDTTRLPVTDVSSASTGHATPLPVTSTSSASTGDTT 3823

Query: 3368 PCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQ-VQRAQAET 3426
            P P +         ++ +P  S+ +  T           G A   P   T  V    A  
Sbjct: 3824 PLPVTDTSSVSTGHATSLPVTSRSSAST-----------GHATPLPVTDTSSVSTGHATP 3872

Query: 3427 GPTSFPSPVSVSMKPDLPVSLPT--QTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQ 3484
             P +  S VS      LPV+ P+   T    P+ V +TS  ST     LP T        
Sbjct: 3873 LPVTSTSSVSTGHATPLPVTSPSSASTGHATPVPVTSTSSASTGDTTPLPVTNASSLSTG 3932

Query: 3485 DSSP-HLTS 3492
             ++P H+TS
Sbjct: 3933 HATPLHVTS 3941



 Score = 97.1 bits (240), Expect = 3e-19
 Identities = 262/1167 (22%), Positives = 396/1167 (33%), Gaps = 148/1167 (12%)

Query: 2390 PHSTPPQSCTSDLSKIPSTENSS----QEISVEERTPTKASVPPDLPPPPQPAPVDEEPQ 2445
            P ++P  + T   + +P T+ SS    Q  ++   + + AS     P P          Q
Sbjct: 2978 PVTSPSSASTGHTTPLPVTDTSSASTGQATALPVTSTSSASTGDTTPLPVTDTSSASTGQ 3037

Query: 2446 AR----FRVHSIIESD----PVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTK 2497
            A       + S+   D    PVT PS  S    T   VT A      AS G     P T 
Sbjct: 3038 ATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDASS----ASTGQATPLPVTS 3093

Query: 2498 VTEWITRQEEPRAQSTPSPALPPDTKASDV-DTSSSTLRKILMDPKYVSATSVTSTSVTT 2556
            ++   T    P   ++PS A      +  V DTSS++       P  V+ TS   T  TT
Sbjct: 3094 LSSVSTGDTTPLPVTSPSSASTGHATSLPVTDTSSASTGDTTSLP--VTDTSSAYTGDTT 3151

Query: 2557 AIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAP 2616
            ++    +++    +  P  V     +    A P+       AS             V +P
Sbjct: 3152 SLPVTDTSSSSTGDTTPLLVTETSSVSTGHATPLLVTDASSAS-----TGHATPLHVTSP 3206

Query: 2617 KITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSV 2676
               S     PV +   +S     A P P  +TGL SA TG  + + +PV  +     G  
Sbjct: 3207 SSASTGDTTPVPVTDTSSVSTGHATPLP--VTGLSSASTG--DTTRLPVTDISSASTGQA 3262

Query: 2677 TTLK----SLVSTPAGPVNVLKGPVNVLTGPVNVL--TTPVNATVGTVNAAPGTVNAAAS 2730
            T L     S VST       +  P +  TG    L  T+  +A+ G     P T  ++AS
Sbjct: 3263 TPLPVTNTSSVSTGDTMPLPVTSPSSASTGHATPLPVTSTSSASTGHATPVPVTSTSSAS 3322

Query: 2731 AVNATASAVTVTAGA---------VTAASGGVTATTGT--VTMAGAVIAPSTKCKQRASA 2779
              + T   VT T+ A         VT+ S   T  T    VT+  +     T       A
Sbjct: 3323 TGHTTPLPVTDTSSASTGDTTPLPVTSPSSASTGHTTPLHVTIPSSASTGDTSTLPVTGA 3382

Query: 2780 NENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPP 2839
            +  S  H   +PV D      G    L V +   V     +G  T  P    A  +    
Sbjct: 3383 SSASTGHATPLPVTDTSSVSTGHATPLPVTSLSSVS----TGDTTPLPVT-DASSASTGQ 3437

Query: 2840 ASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVI 2899
            A+ + +    SVS     P  VT +   S G   P    + ++ ST   T      +   
Sbjct: 3438 ATPLPVTSLSSVSTGDTTPLLVTDASSVSTGHATPLPVTDTSSASTGDTTRLPVTDTSSA 3497

Query: 2900 SSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKK 2959
            S+ +A    +     +    +TP+       V T G  TP  +       T    TT   
Sbjct: 3498 STGQATPLPVTSLSSVSTGDTTPLLVTDASSVST-GHATPLPVTDTSSASTGD--TTRLP 3554

Query: 2960 LADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVN--HV-PSGPSIPADRTVSHL 3016
            + D  +         P  + S+ +  H   LP    + V+  HV P   + P+  +  H+
Sbjct: 3555 VTDTSSASTGQATPLPVTIPSSSSSGHTTPLPVTSTSSVSTGHVTPLHVTSPSSASTGHV 3614

Query: 3017 AAAKLDAHSPRPSGPG-PSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQ 3075
                + + S   +G   P     AS  S+  +T L        + G   P  ++      
Sbjct: 3615 TPLPVTSTSSASTGHATPLLVTDASSVSTGHATPLPVTDASSASTGDTTPLPVTDTSSAS 3674

Query: 3076 SVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIE----- 3130
            +    P  +T   SLS +S G+    T  LP    S       +P     P  +      
Sbjct: 3675 TGQATPLPVT---SLSSVSTGD----TTPLPVTDASSASTGHATPLPVTIPSSVSTGDTM 3727

Query: 3131 ---VRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLH 3187
               V +P  AST    P  V  L+S    +            T P+   V    S    H
Sbjct: 3728 PLPVTSPSSASTGHATPLPVTGLSSASTGD------------TTPLP--VTDTSSASTRH 3773

Query: 3188 PYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTP 3247
               +P          VT  S    + D   ++P    +    G  A   P    +   T 
Sbjct: 3774 ATPLP----------VTDTSSA--STDDTTRLPVTDVSSASTG-HATPLPVTSTSSASTG 3820

Query: 3248 APVPVPV--------------PLPAPAPAPHGEARILTVTPSNQLQGLPLTP-PVVVTHG 3292
               P+PV              P+ + + A  G A  L VT ++ +     TP PV  T  
Sbjct: 3821 DTTPLPVTDTSSVSTGHATSLPVTSRSSASTGHATPLPVTDTSSVSTGHATPLPVTSTSS 3880

Query: 3293 VQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQ 3352
            V   H++                 P  +T    P+++S G  +     +      G+   
Sbjct: 3881 VSTGHAT-----------------PLPVTS---PSSASTGHATPVPVTSTSSASTGDTTP 3920

Query: 3353 PPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLP------A 3406
             P    S+     A P   +      +  +S +P    +A    TG   P LP       
Sbjct: 3921 LPVTNASSLSTGHATPLHVTSPSSASRGDTSTLPVT--DASSASTGHATP-LPLTSLSSV 3977

Query: 3407 GPANRPPEPHTQVQRA---QAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTT- 3462
               +  P P T    A   QA   P +  S VS      LPV++P+  +      +P T 
Sbjct: 3978 STGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTIPSSASSGHTTSLPVTD 4037

Query: 3463 -SGPSTPPGLVLPHTEFQPAPKQDSSP 3488
             S  ST  G  LP T    A   D++P
Sbjct: 4038 ASSVSTGHGTPLPVTSTSSASTGDTTP 4064



 Score = 90.1 bits (222), Expect = 4e-17
 Identities = 261/1184 (22%), Positives = 395/1184 (33%), Gaps = 183/1184 (15%)

Query: 2391 HSTPPQSC-TSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFR 2449
            H T P S  T   + +P T  SS          T  ++P  +  P   +  D  P     
Sbjct: 1506 HVTSPSSASTGHATPLPVTSLSSAS--------TGDTMPLPVTSPSSASTGDTTPLPVTD 1557

Query: 2450 VHSIIESD----PVTPPSDPSI----PIPTLPSVTAAK--------LSPPVASGGIPHQS 2493
              S+        PVT PS  S     P+P   + +A+K         SP  AS G     
Sbjct: 1558 ASSVSTGHTTPLPVTSPSSASTGHTTPLPVTDTSSASKGDTTPLPVTSPSSASTGHTTPL 1617

Query: 2494 PPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTS 2553
            P T  +   T        +TP P     T AS + T  +T       P +V++ S  ST 
Sbjct: 1618 PVTDTSSAST------GDTTPLPV----TNASSLSTGHAT-------PLHVTSPSSASTG 1660

Query: 2554 VTTAIAEPVSAAPCLHEAPPPPVD--SKKPLEEKTAPPVTNNSEIQASEVL--------- 2602
              T +    +++     A P PV   S    ++ T  PVT+ S     +           
Sbjct: 1661 HATPLPVTSTSSASTGHATPLPVTGLSSATTDDTTRLPVTDVSSASTGQATPLPVTSLSS 1720

Query: 2603 VAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSL 2662
            V+       PV +P   S     P+ +   +S     A P P T T  VS      + + 
Sbjct: 1721 VSTGDTTPLPVTSPSSASTGHASPLLVTDASSASTGQATPLPVTDTSSVST----AHATP 1776

Query: 2663 VPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAP 2722
            +PV  L        T L     + A     +  PV          T+P +A+ G     P
Sbjct: 1777 LPVTGLSSASTDDTTRLPVTDVSSASTGQAIPLPV----------TSPSSASTGDTTPLP 1826

Query: 2723 GTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANEN 2782
             T  ++AS  + T+  VT+     ++AS G T T+  VT A +V            A+  
Sbjct: 1827 VTDASSASTGDTTSLPVTIP----SSASSGHT-TSLPVTDASSVSTGHATSLLVTDASSV 1881

Query: 2783 SRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASA 2842
            S      +PV D   A  G    L V  +  V     +G  T  P      ++ +  AS 
Sbjct: 1882 STGDTTPLPVTDTNSASTGDTTPLHVTDASSV----STGHATSLP------VTSLSSAST 1931

Query: 2843 MDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSV 2902
             D       S S       T   P +     P G+A  +   T   +  T +A+P +   
Sbjct: 1932 GDTTPLPVTSPSSAS-SGHTTPLPVTDASSVPTGHA-TSLPVTDASSVSTGHATP-LPVT 1988

Query: 2903 KADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLT-PSIVTTNKKLA 2961
             A   S     P+ ++ ++ V+ G    +    +++        L +T  S  +T +   
Sbjct: 1989 DASSVSTGHATPLPVTDTSSVSTGQATPLPVTSLSSASTGDTTPLPVTDTSSASTGQDTP 2048

Query: 2962 DPVTLKI-----ETKVLQPANLGSTLTPHHPPAL------------PSKLPTEVNHVPSG 3004
             PVT        +T  L   +  S  T H  P L             S L T+ + V +G
Sbjct: 2049 LPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDASSVSTGHATSLLVTDASSVSTG 2108

Query: 3005 PSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPV 3064
             +     T  H+  A   + S   + P P + P ++    T    ++  ++V       +
Sbjct: 2109 HA-----TALHVTDA--SSLSTGDTTPLPVTSPSSASTGDTTPLPVTDTSSVSTGHATSL 2161

Query: 3065 PQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPL 3124
            P   +S          P + T + S  H +   V   T T  + T    P  + SP +  
Sbjct: 2162 PVTDTSSASTGHATSLPVTDTSSASTGHATPLPV---TDTSSASTGQATPLPVTSPSSAS 2218

Query: 3125 QPQQIE--VRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQS 3182
                I   V     AST Q  P  V +L+S    +      LPV  A++           
Sbjct: 2219 TGHAIPLLVTDTSSASTGQATPLPVTSLSSASTGDTT---PLPVTDASSVSTG------- 2268

Query: 3183 EYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEA-AKTPDAKA 3241
                H  ++P          VT++S    +      +P  S +    G        DA +
Sbjct: 2269 ----HATSLP----------VTSLSSV--STGDTTPLPVTSPSSASTGHATPLHVTDASS 2312

Query: 3242 APTPTPAPVPV------------PVPLPAPAPAPHGEARILTVTPSNQLQGLPLTP-PVV 3288
            A T    P+PV            P+P+ +P+ A  G A  L VT ++ +     TP PV 
Sbjct: 2313 ASTGHATPLPVTSLSSASTGDTTPLPVTSPSSASTGHATPLHVTDASSVSTGDTTPLPVT 2372

Query: 3289 VTHGVQIVHSSGELFQEYRYGDIRTYHP----------PAQLTHTQFPAASSVGLPSRTK 3338
             +      H++     +          P              TH      SS      T+
Sbjct: 2373 SSSSASSGHTTPLPVTDASSASTGDTTPLPVTDTSSASTGHATHLPVTGLSSASTGDTTR 2432

Query: 3339 TAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTG 3398
                           P PV ST  A      P               P +  +A    TG
Sbjct: 2433 LPVTNVSSASTGHATPLPVTSTSSASTGDTTPLPGTDTSSVSTGHTTPLLVTDASSVSTG 2492

Query: 3399 VEQPRLPAGPANRPPEPHTQ----VQRAQAETGPTSFPSPV----------SVSMKPDLP 3444
             +  RLP    +     HT          A TG T+ P PV          + S+    P
Sbjct: 2493 -DTTRLPVTSPSSASTGHTTPLPVTDTPSASTGDTT-PLPVTNASSLSTRHATSLHVTSP 2550

Query: 3445 VSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSP 3488
             S  T  A   P  V  TS  ST     LP T    A   D++P
Sbjct: 2551 SSASTGHATSLP--VTDTSAASTGHATPLPVTSTSSASTGDTTP 2592



 Score = 86.3 bits (212), Expect = 5e-16
 Identities = 319/1548 (20%), Positives = 483/1548 (31%), Gaps = 189/1548 (12%)

Query: 2032 AAEEEAGSEQKRDRKDAGTDKNPP----ETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAV 2087
            A+   A S    D   A T    P    +T+     +  P P   S S         L V
Sbjct: 2169 ASTGHATSLPVTDTSSASTGHATPLPVTDTSSASTGQATPLPV-TSPSSASTGHAIPLLV 2227

Query: 2088 DKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKE 2147
              ++S     A   P  + + A   ++  + V+   S S      L     S     D  
Sbjct: 2228 TDTSSASTGQATPLPVTSLSSASTGDTTPLPVTDASSVSTGHATSLPVTSLSSVSTGDTT 2287

Query: 2148 PEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPA 2207
            P      +S  +  AT L        +  H   L   S S+A   D              
Sbjct: 2288 PLPVTSPSSASTGHATPLHVTDASSASTGHATPLPVTSLSSASTGDTTPLPVTSPSSAST 2347

Query: 2208 HQASETELAAAIGSIINDISGEP----------ENFPAPPPYPGESQTDLQPPAGAQALQ 2257
              A+   +  A      D +  P             P P      + T    P       
Sbjct: 2348 GHATPLHVTDASSVSTGDTTPLPVTSSSSASSGHTTPLPVTDASSASTGDTTPLPVTDTS 2407

Query: 2258 PSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKG 2317
             +  G  T   V+G+        +  P  N    S G          SS ++       G
Sbjct: 2408 SASTGHATHLPVTGLSSASTGDTTRLPVTNVSSASTGHATPLPVTSTSSASTGDTTPLPG 2467

Query: 2318 SKEVEVTLVRKDKGRQKTTRSRRKRNTNK-KVVAPVESHVPESNQAQ-GESPAANEGTTV 2375
            +    V+             S    +T +  V +P  +    +      ++P+A+ G T 
Sbjct: 2468 TDTSSVSTGHTTPLLVTDASSVSTGDTTRLPVTSPSSASTGHTTPLPVTDTPSASTGDTT 2527

Query: 2376 QHP---EAPQEEKQSEKPHSTPPQSC-TSDLSKIPSTENSSQEISVEERTPTKASVPPDL 2431
              P    +    + +   H T P S  T   + +P T+ S+         P   S     
Sbjct: 2528 PLPVTNASSLSTRHATSLHVTSPSSASTGHATSLPVTDTSAASTGHATPLPV-TSTSSAS 2586

Query: 2432 PPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPH 2491
                 P PV +   A     + +   PVT  S  S    T   VT        AS G   
Sbjct: 2587 TGDTTPLPVTDTYSASTGQATPL---PVTDTSSASTGDTTPLPVTDTSS----ASTGHAT 2639

Query: 2492 QSPPTKVTEWITRQEEPRAQSTPSPALP------PDTKASDVDTSSSTLRKILMDPKYVS 2545
              P T  +   T    P   ++PS A        P T AS V T  +T   +        
Sbjct: 2640 PLPVTNTSSVSTGHATPLHVTSPSSASTGHTTPLPVTDASSVSTGHATSLPV------TD 2693

Query: 2546 ATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVD-SKKPLEEKTAPPVTNNSEIQASEVLVA 2604
            A+SV +   T+      S+A   H  P P  D S       T+ PVT+ S +        
Sbjct: 2694 ASSVFTGHATSLPVTIPSSASSGHTTPLPVTDASSVSTGHATSLPVTDASSVSTGHA--- 2750

Query: 2605 ADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVP 2664
                   P+     +SV +     + L +   ++     P  +T   SA TG    + +P
Sbjct: 2751 ------TPLPVTDASSVSTGHATPLPLTSLSSVSTGDTTPLPVTDTSSASTG--QATPLP 2802

Query: 2665 VNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGT 2724
            V +L     G  T L    ++ A   +    PV          T   +A+ G     P T
Sbjct: 2803 VTSLSSVSTGDTTPLPVTDTSSASTGHATSLPV----------TDTSSASTGHATPLPDT 2852

Query: 2725 VNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSR 2784
              ++AS  +AT   VT T+ A         AT+  VT   ++           S +  S 
Sbjct: 2853 DTSSASTGHATLLPVTDTSSASIGH-----ATSLPVTDTSSISTGHATPLHVTSPSSAST 2907

Query: 2785 FHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMD 2844
             H   +PV D   A  G    L V +       + +G  T  P   ++  S    A+ + 
Sbjct: 2908 GHATPLPVTDTSSASTGHANPLHVTSPSS----ASTGHATPLPVTDTSSAST-GHATPLP 2962

Query: 2845 IEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKA 2904
            +    SVS     P  VT+    S G   P    + ++ ST   TA      PV S+  A
Sbjct: 2963 VTSLSSVSTGDTTPLPVTSPSSASTGHTTPLPVTDTSSASTGQATAL-----PVTSTSSA 3017

Query: 2905 DRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPV 2964
                           +TP+    T    T      PV        + S V+T      PV
Sbjct: 3018 STGD-----------TTPLPVTDTSSASTGQATPLPVT-------SLSSVSTGDTTPLPV 3059

Query: 2965 TLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAH 3024
            T           +  S  T H  P L     T+ +   +G + P    V+ L++      
Sbjct: 3060 T-----------SPSSASTGHATPLLV----TDASSASTGQATPLP--VTSLSSVSTGDT 3102

Query: 3025 SPRP-SGPGPSSFPRASHPSSTASTALSTNATVML------------AAGIPVPQFISSI 3071
            +P P + P  +S   A+    T +++ ST  T  L               +PV    SS 
Sbjct: 3103 TPLPVTSPSSASTGHATSLPVTDTSSASTGDTTSLPVTDTSSAYTGDTTSLPVTDTSSSS 3162

Query: 3072 HPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPL--QPQQI 3129
              + + ++    +T+T S+S        + T    + T    P  + SP +        +
Sbjct: 3163 TGDTTPLL----VTETSSVS-TGHATPLLVTDASSASTGHATPLHVTSPSSASTGDTTPV 3217

Query: 3130 EVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATA---------PVQSEVLVM 3180
             V      ST    P  V  L+S    +      LPV   ++         PV +   V 
Sbjct: 3218 PVTDTSSVSTGHATPLPVTGLSSASTGDTT---RLPVTDISSASTGQATPLPVTNTSSVS 3274

Query: 3181 QSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAA-KTPDA 3239
              +    P T P          +   S    +      VP  S +    G        D 
Sbjct: 3275 TGDTMPLPVTSPSSASTGHATPLPVTSTSSASTGHATPVPVTSTSSASTGHTTPLPVTDT 3334

Query: 3240 KAAPTPTPAPVPVPVPLPA------------PAPAPHGEARILTVTPSNQLQGLPLTP-P 3286
             +A T    P+PV  P  A            P+ A  G+   L VT ++       TP P
Sbjct: 3335 SSASTGDTTPLPVTSPSSASTGHTTPLHVTIPSSASTGDTSTLPVTGASSASTGHATPLP 3394

Query: 3287 VVVTHGVQIVHSSG---ELFQEYRYGDIR-------TYHPPAQLTHTQFPAASSVGLPSR 3336
            V  T  V   H++            GD         +     Q T     + SSV     
Sbjct: 3395 VTDTSSVSTGHATPLPVTSLSSVSTGDTTPLPVTDASSASTGQATPLPVTSLSSVSTGDT 3454

Query: 3337 TKTAAQGPPPEGEPLQPPQPVQSTQPAQ-------PAPPCPPSQLGQPGQPPSSKMPQVS 3389
            T                P PV  T  A        P      +  GQ    P + +  VS
Sbjct: 3455 TPLLVTDASSVSTGHATPLPVTDTSSASTGDTTRLPVTDTSSASTGQATPLPVTSLSSVS 3514

Query: 3390 QEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETG-----PTSFPSPVSVSMKPDLP 3444
                      +   +  G A   P   T    + A TG     P +  S  S      LP
Sbjct: 3515 TGDTTPLLVTDASSVSTGHATPLPVTDT----SSASTGDTTRLPVTDTSSASTGQATPLP 3570

Query: 3445 VSLPTQTAPKQPLFVPTTSGPSTPPGLVLP-HTEFQPAPKQDSSPHLT 3491
            V++P+ ++      +P TS  S   G V P H     +P   S+ H+T
Sbjct: 3571 VTIPSSSSSGHTTPLPVTSTSSVSTGHVTPLHV---TSPSSASTGHVT 3615



 Score = 65.5 bits (158), Expect = 9e-10
 Identities = 226/1077 (20%), Positives = 362/1077 (33%), Gaps = 150/1077 (13%)

Query: 2469 IPTLPSVTAAKLSPPVASGGIPHQSP--PTKVTEWITRQEEPRAQSTPSPALPPDTKASD 2526
            +P+  +  A +L     S G     P  P+KV+  I    EP   S+ S  LP  T A  
Sbjct: 505  LPSTSTGAATRLVTGNPSTGTAGTIPRVPSKVSA-IGEPGEPTTYSSHSTTLPKTTGAGA 563

Query: 2527 ----VDTSSSTLRKILMDPKY-VSATSVTSTSVTTA------IAEPVSAAPCLHEAPPPP 2575
                   + +T   +L  P Y V+    T+TS +++       ++ ++ AP  + +    
Sbjct: 564  QTQWTQETGTTGEALLSSPSYSVTQMIKTATSPSSSPMLDRHTSQQITTAPSTNHSTIHS 623

Query: 2576 VDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEK-VAPVIAPKITSVISRMPVSIDLENS 2634
              S  P E   +P V+     QA +    +   + V+P+   K  +       +     S
Sbjct: 624  T-STSPQE---SPAVSQRGHTQAPQTTQESQTTRSVSPMTDTKTVTTPGSSFTASGHSPS 679

Query: 2635 QKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLK 2694
            + +    P     T    A TG  + +  P  AL+        TL      P+G  ++ K
Sbjct: 680  EIVPQDAPTISAATTFAPAPTGDGHTTQAPTTALQAAPSSHDATLG-----PSGGTSLSK 734

Query: 2695 GPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVT-----AA 2749
                 LT   +V++TP        +A+  T    A+A+  T  A +  A   T     A+
Sbjct: 735  --TGALTLANSVVSTPGGPEGQWTSASASTSPDTAAAMTHTHQAESTEASGQTQTSEPAS 792

Query: 2750 SGGVTATTGTV--TMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLR 2807
            SG  T + GT   + +GA     +  +  +++ E +RF   S P  D     + +   L 
Sbjct: 793  SGSRTTSAGTATPSSSGASGTTPSGSEGISTSGETTRF--SSNPSRDSHTTQSTTEL-LS 849

Query: 2808 VNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQV--KPDSVTASQ 2865
             + S G + +S            +   S I P +     F  ++S++    +P   ++  
Sbjct: 850  ASASHGAIPVS------------TGMASSIVPGT-----FHPTLSEASTAGRPTGQSSPT 892

Query: 2866 PPSKGPQAPAGYANVATHSTLVLTAQTYNASPVIS--SVKADRPSLEKPEPIHLS---VS 2920
             PS  PQ  A  + +A         +T   S  IS  S   D  S   P P  ++   ++
Sbjct: 893  SPSASPQETAAISRMAQ----TQRTRTSRGSDTISLASQATDTFSTVPPTPPSITSTGLT 948

Query: 2921 TPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGS 2980
            +P T+  T+     G      L+ N    TP  VT     +        T  L   +  S
Sbjct: 949  SPQTETHTLSPSGSGKTFTTALISN---ATPLPVTYASSASTG-----HTTPLHVTDASS 1000

Query: 2981 TLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRAS 3040
              T H  P LP   P+ V+   +G + P   T         D  S       P      S
Sbjct: 1001 VSTGHATP-LPVTSPSSVS---TGHTTPLPVT---------DTSSESTGHVTPLPVTSFS 1047

Query: 3041 HPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLS--HLSQGEV 3098
              S+  ST L    T   + G   P  ++S+    +    P  +T T S S  H +   V
Sbjct: 1048 SASTGDSTPLPVTDTSSASTGHVTPLPVTSLSSASTGDTTPLPVTDTSSASTGHATSLPV 1107

Query: 3099 RMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEE 3158
              +T ++ +   +  P    S  +      + V      ST    P  V   +S    + 
Sbjct: 1108 -TDTSSVSTGHTTPLPVTDTSSASTGHATSLPVTDTSSVSTGHTTPLHVTDASSASTGQ- 1165

Query: 3159 EVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVK 3218
                         PV S   V   +    P T P       H     V++   A+ G   
Sbjct: 1166 ---------ATPLPVTSLSSVSTGDTTPLPVTSPSSAS-TGHATPLLVTDTSSASTGHAT 1215

Query: 3219 VPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQL 3278
              P + A       A   P     P+        P+P+   + A  G+A  L VT ++ +
Sbjct: 1216 PLPVTDASSVSTDHATSLP--VTIPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSV 1273

Query: 3279 QGLPLTP-PVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRT 3337
                 TP PV  T      H +                      H   P+++S G  +  
Sbjct: 1274 STGDTTPLPVTSTSSASTGHVTP--------------------LHVTSPSSASTGHATPL 1313

Query: 3338 KTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQT 3397
               +      G+ +  P PV S   A      P               P    +A    T
Sbjct: 1314 PVTSLSSASTGDTM--PLPVTSPSSASTGDTTPLPVTDASSVSTGHTTPLHVTDASSAST 1371

Query: 3398 GVEQP-------------------RLPAGPANRPPEPHTQVQRAQAETG-----PTSFPS 3433
            G   P                     P+  +     P      + A TG     P +  S
Sbjct: 1372 GQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDTSSASTGHATPLPVTDAS 1431

Query: 3434 PVSVSMKPDLPVSLPT--QTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSP 3488
             VS      LPV++P+   T    PL V  TS  ST     L  T+       D++P
Sbjct: 1432 SVSTDHATSLPVTIPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSVSTGDTTP 1488



 Score = 57.4 bits (137), Expect = 3e-07
 Identities = 262/1275 (20%), Positives = 431/1275 (33%), Gaps = 170/1275 (13%)

Query: 2296 TDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESH 2355
            T T    GN+ ETS +  E+       V++    +G+ +TT     R + +   A  ++H
Sbjct: 142  TSTDSTLGNTEETSTAGTESSTPVTSAVSITAGQEGQSRTT---SWRTSIQDTSASSQNH 198

Query: 2356 VPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEI 2415
               S Q   ES    + +T+ H           +  STP  S        PS  N +  +
Sbjct: 199  WTRSTQTTRES----QTSTLTH-----------RTTSTPSFS--------PSVHNVTGTV 235

Query: 2416 SVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIP-TLPS 2474
            S ++ +P+  +    L      + +  E   +  V +   S    P    S+P+  +L  
Sbjct: 236  S-QKTSPSGETATSSLCSVTNTSMMTSE---KITVTTSTGSTLGNPGETSSVPVTGSLMP 291

Query: 2475 VTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSS-- 2532
            VT+A L      G  P     T   +     +  + QS  +      T+ S ++T ++  
Sbjct: 292  VTSAALVTFDPEGQSPATFSRTSTQDTTAFSKNHQTQSVET------TRVSQINTLNTLT 345

Query: 2533 --TLRKILMDPK------YVSATSVTSTSVTTAIAEPVSAAPCLHE---APPPPVDSKKP 2581
              T   +L  P        VS  +  S   TT+    VS    +       P   DS   
Sbjct: 346  PVTTSTVLSSPSGFNPSGTVSQETFPSGETTTSSPSSVSNTFLVTSKVFRMPTSRDSTLG 405

Query: 2582 LEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKI-TLA 2640
              E+T+  V+       S+V      + ++  ++P  +S+  ++  +   + S+   T  
Sbjct: 406  NTEETSLSVSGTISAITSKVSTIWWSDTLSTALSP--SSLPPKISTAFHTQQSEGAETTG 463

Query: 2641 KPAPQT--LTGLVSALTGLVNVSLVPVN-ALKGPVKGSVTTLKSLVSTPAGPVNVLKGPV 2697
            +P  ++    G+   +  L   +  P + + KG    S T L S  ST A          
Sbjct: 464  RPHERSSFSPGVSQEIFTLHETTTWPSSFSSKGHTTWSQTELPS-TSTGAA--------T 514

Query: 2698 NVLTGPVNVLTTPVNATVGTVNAAPGTVNAAAS-------AVNATASAVTVTAGAVTAAS 2750
             ++TG       P   T GT+   P  V+A          + ++T    T  AGA T  +
Sbjct: 515  RLVTG------NPSTGTAGTIPRVPSKVSAIGEPGEPTTYSSHSTTLPKTTGAGAQTQWT 568

Query: 2751 GGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNT 2810
               T TTG   ++    + +   K   S + +      +   I   P+   S       +
Sbjct: 569  -QETGTTGEALLSSPSYSVTQMIKTATSPSSSPMLDRHTSQQITTAPSTNHSTIHSTSTS 627

Query: 2811 SEGVVLLSYSGQKTEGPQ--------RISAKISQIPPASAMDIEFQQS-VSKSQVKP-DS 2860
             +    +S  G  T+ PQ        R  + ++     +     F  S  S S++ P D+
Sbjct: 628  PQESPAVSQRGH-TQAPQTTQESQTTRSVSPMTDTKTVTTPGSSFTASGHSPSEIVPQDA 686

Query: 2861 VTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVS 2920
             T S   +  P AP G  +     T  L A   +    +    +   SL K   + L+ S
Sbjct: 687  PTISAATTFAP-APTGDGHTTQAPTTALQAAPSSHDATLG--PSGGTSLSKTGALTLANS 743

Query: 2921 TPVTQGGTVKVLTQ-GINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLG 2979
               T GG     T    +T P           +   T+   A+      +T+  +PA+ G
Sbjct: 744  VVSTPGGPEGQWTSASASTSP---------DTAAAMTHTHQAESTEASGQTQTSEPASSG 794

Query: 2980 S------TLTPHHPPA-----------LPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLD 3022
            S      T TP    A             S   T  +  PS  S     T   L+A+   
Sbjct: 795  SRTTSAGTATPSSSGASGTTPSGSEGISTSGETTRFSSNPSRDSHTTQSTTELLSASASH 854

Query: 3023 AHSPRPSGPGPSSFPRASHPS-STASTALSTNATVMLAAGIPVPQFISSI-HPEQSVIMP 3080
               P  +G   S  P   HP+ S ASTA          +    PQ  ++I    Q+    
Sbjct: 855  GAIPVSTGMASSIVPGTFHPTLSEASTAGRPTGQSSPTSPSASPQETAAISRMAQTQRTR 914

Query: 3081 PHSITQTVSLSHLSQGEVRMNTPTLPSITYS--IRPEALHSPRAPLQPQQIEVRAPQRAS 3138
                + T+SL+  +        PT PSIT +    P+      +P    +    A    +
Sbjct: 915  TSRGSDTISLASQATDTFSTVPPTPPSITSTGLTSPQTETHTLSPSGSGKTFTTALISNA 974

Query: 3139 TPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIM 3198
            TP P      A      P      H+  A + +   +  L         P T P  V   
Sbjct: 975  TPLPVTYASSASTGHTTP-----LHVTDASSVSTGHATPL---------PVTSPSSVST- 1019

Query: 3199 VHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTP----DAKAAPTPTPAPVPV-- 3252
               H T +     +++    V P              TP    D  +A T    P+PV  
Sbjct: 1020 --GHTTPLPVTDTSSESTGHVTPLPVTSFSSASTGDSTPLPVTDTSSASTGHVTPLPVTS 1077

Query: 3253 ----------PVPLPAPAPAPHGEARILTVTPSNQLQGLPLTP-PVVVTHGVQIVHSSGE 3301
                      P+P+   + A  G A  L VT ++ +     TP PV  T      H++  
Sbjct: 1078 LSSASTGDTTPLPVTDTSSASTGHATSLPVTDTSSVSTGHTTPLPVTDTSSASTGHATSL 1137

Query: 3302 LFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQ 3361
               +     + T H      H    +++S G  +     +      G+    P    S+ 
Sbjct: 1138 PVTD--TSSVSTGHTTP--LHVTDASSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSA 1193

Query: 3362 PAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQP-RLPAGPANRPPEPHTQVQ 3420
                A P   +         ++ +P     +  T      P  +P+  +     P     
Sbjct: 1194 STGHATPLLVTDTSSASTGHATPLPVTDASSVSTDHATSLPVTIPSAASTGHTTPLPVTD 1253

Query: 3421 RAQAETGPTSF-----PSPVSVSMKPDLPVSLPT--QTAPKQPLFVPTTSGPSTPPGLVL 3473
             + A TG  +       S VS      LPV+  +   T    PL V + S  ST     L
Sbjct: 1254 TSSASTGQATSLLVTDTSSVSTGDTTPLPVTSTSSASTGHVTPLHVTSPSSASTGHATPL 1313

Query: 3474 PHTEFQPAPKQDSSP 3488
            P T    A   D+ P
Sbjct: 1314 PVTSLSSASTGDTMP 1328



 Score = 49.3 bits (116), Expect = 7e-05
 Identities = 93/429 (21%), Positives = 156/429 (36%), Gaps = 71/429 (16%)

Query: 2364 GESPAANEGTTVQHPEAPQEEKQSEKPHSTP------PQSCTSDLSKIPSTENSSQEISV 2417
            G S A+   TT   P    +   +   H+TP        + T D +++P T+ SS     
Sbjct: 3749 GLSSASTGDTT---PLPVTDTSSASTRHATPLPVTDTSSASTDDTTRLPVTDVSSASTGH 3805

Query: 2418 EERTP---TKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPS 2474
                P   T ++   D  P P                 + ++  V+     S+P+ +  S
Sbjct: 3806 ATPLPVTSTSSASTGDTTPLP-----------------VTDTSSVSTGHATSLPVTSRSS 3848

Query: 2475 VTAAKLSP-PV---ASGGIPHQSP-PTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDT 2529
             +    +P PV   +S    H +P P   T  ++        +TP P   P    S   T
Sbjct: 3849 ASTGHATPLPVTDTSSVSTGHATPLPVTSTSSVST-----GHATPLPVTSP----SSAST 3899

Query: 2530 SSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLE----EK 2585
              +T       P  V++TS  ST  TT +  PV+ A  L      P+    P      + 
Sbjct: 3900 GHAT-------PVPVTSTSSASTGDTTPL--PVTNASSLSTGHATPLHVTSPSSASRGDT 3950

Query: 2586 TAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQ 2645
            +  PVT+ S         +A      P+    ++SV +     + + ++   +  +  P 
Sbjct: 3951 STLPVTDAS---------SASTGHATPLPLTSLSSVSTGDTTPLPVTDTSSASTGQATPL 4001

Query: 2646 TLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLK----SLVSTPAGPVNVLKGPVNVLT 2701
             +T L S  TG  + + +PV        G  T+L     S VST  G    +    +  T
Sbjct: 4002 PVTSLSSVSTG--DTTPLPVTIPSSASSGHTTSLPVTDASSVSTGHGTPLPVTSTSSAST 4059

Query: 2702 GPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVT 2761
            G    L     ++  T +A P  V   +SA    A+ + VT+ +  +          + T
Sbjct: 4060 GDTTPLPVTDTSSASTGHATPLPVTDTSSASTGHATPLPVTSLSSVSTGHATPLAVSSAT 4119

Query: 2762 MAGAVIAPS 2770
             A  V + S
Sbjct: 4120 SASTVSSDS 4128



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 24/89 (26%), Positives = 47/89 (52%), Gaps = 2/89 (2%)

Query: 240 SRSRSPHSSQSRNQSPQRLASQASRPTRS--PSGSGSRSRSSSSDSISSSSSTSSDSSDS 297
           S S SP ++ +   + Q  +++AS  T++  P+ SGSR+ S+ + + SSS ++ +  S S
Sbjct: 759 SASTSPDTAAAMTHTHQAESTEASGQTQTSEPASSGSRTTSAGTATPSSSGASGTTPSGS 818

Query: 298 SSSSSDDSPARSVQSAAVPAPTSQLLSSL 326
              S+     R   + +  + T+Q  + L
Sbjct: 819 EGISTSGETTRFSSNPSRDSHTTQSTTEL 847


>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
          Length = 2089

 Score = 96.7 bits (239), Expect = 4e-19
 Identities = 220/1028 (21%), Positives = 342/1028 (33%), Gaps = 159/1028 (15%)

Query: 1589 ELTRMQQKEKEKDQKPKEVEKQEDTEN-HPKTPESAPENKDSELKTPPSVGPPSVTVVTL 1647
            ELT+ +Q  ++K    ++ ++QE  +N    +PE   E+   E++T   +    V   TL
Sbjct: 851  ELTKGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVEIETSEEIQEKQVQKQTL 910

Query: 1648 ESA--PSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLP-- 1703
             S      +E+   ++  + P   EEK   P  + E      EP     +Q  Q   P  
Sbjct: 911  PSKAFEREVERPVANRECD-PAELEEKV--PKVILERDTQRGEPEGGSQDQKGQASSPTP 967

Query: 1704 -PGAD----PDKEAAMMPAGVEEGSSGD-------QPPYLDAK-PPTPGASFSQAESNV- 1749
             PG      P   +A +P+G + G  G        Q   L+ K PP   AS  +A   V 
Sbjct: 968  EPGVGAGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVS 1027

Query: 1750 --DPE----------PDSTQPLSKPA-QKSEEANEPKAEKPDATADAEPDANQKAEAAPE 1796
              D E          P++  P  KP   +S++   P           +P   +  +   +
Sbjct: 1028 RGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQ 1087

Query: 1797 SQP--PASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKR 1854
              P  P S +LE   P   K K   +     TP  A + +    P T  ++ +  +   +
Sbjct: 1088 EAPEAPLSSELE---PFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQ 1144

Query: 1855 SNSPRGEAQKLLELKMEAEKITRTASK-NSAADLEHPEPSLPLSR-TRRRNVRSVYAT-- 1910
            +   R     +       E +  TA +   +   + P  S P S+ TR R  RS   T  
Sbjct: 1145 ATRSRTNRSSV----KTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPE 1200

Query: 1911 ----------MGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRA 1960
                           +R    EP  Q    RK           VPT P       T +  
Sbjct: 1201 TVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPV 1260

Query: 1961 DEEEENEA---KEPAETLKPPE-------GWRSPRSQKTAAGGGPQGKKGKNEPKVDATR 2010
              E   +A   ++   ++K PE         R   S        P  +  ++   + + +
Sbjct: 1261 TSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVK 1320

Query: 2011 -PEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNP-------PETAPVEV 2062
             PE      P++ +  S+ +P     +  S   R R +  + KNP       PE  P   
Sbjct: 1321 TPETVVPTAPELQISTSTDQP--VTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTS 1378

Query: 2063 VEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVA---V 2119
             E+   PE  S++ RGR              KN  +  +P      A + E        V
Sbjct: 1379 TEQPVTPEPTSRATRGR--------------KNRSSGKTPETLVPTAPKLEPSTSTDQPV 1424

Query: 2120 SPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIA 2179
            +PE +    +     S +K+        PE +      PS    Q        QA     
Sbjct: 1425 TPEPTSQATRGRTNRSSVKTPETVVPTAPELQ------PSTSTDQPVTPEPTSQATRGRT 1478

Query: 2180 KLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPEN-FPAPPP 2238
              +           APE  A    D+P    SE       G         PE   PA P 
Sbjct: 1479 DRSSVKTPETVVPTAPELQASASTDQPV--TSEPTSRTTRGRKNRSSVKTPETVVPAAPE 1536

Query: 2239 YPGESQTDL----QPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAG 2294
                + TD     +P + A   + +   ++T E++  I   E    +SR  +  P+P++ 
Sbjct: 1537 LQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPI-APELQPSTSRNQLVTPEPTSR 1595

Query: 2295 PTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNK---KVVAP 2351
             T     R N S      P    + E   T         K T    +R TN+   K   P
Sbjct: 1596 AT---RCRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKP 1652

Query: 2352 VE--------------SHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQS 2397
            VE              S  PE+    G+S      T    P     E QS       P +
Sbjct: 1653 VEPAASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEFQS-------PVT 1705

Query: 2398 CTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESD 2457
                +S  P T+ S  +       P   + P D  P   P     +     R  ++  ++
Sbjct: 1706 TDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQRWGAVRAAE 1765

Query: 2458 PVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPA 2517
             +T     +IP P  P +    L  P+      H S   KV        EP  +S  +P 
Sbjct: 1766 SLT-----AIPEPASPQL----LETPI------HASQIQKV--------EPAGRSRFTPE 1802

Query: 2518 LPPDTKAS 2525
            L P    S
Sbjct: 1803 LQPKASQS 1810



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 194/932 (20%), Positives = 326/932 (34%), Gaps = 171/932 (18%)

Query: 1584 HSRFMELTRMQQKEKEKDQKPKEVEKQEDTENH-----PKTPES-APENKDSELKTPPSV 1637
            H + +   +M   EK    +  E   + D E+      P  PE+ AP  K    ++   +
Sbjct: 1002 HQKGLLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHL 1061

Query: 1638 GPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAK----------PAS 1687
             PP +    L S    + KT  D + EAP       +EP     + +          PA+
Sbjct: 1062 APPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPAT 1121

Query: 1688 EPAPAPVEQLEQVDLPPGADPDKEAA--------------MMPAG--VEEGSSGDQPPYL 1731
              AP P         P    P  +A               ++P    ++  +S DQP  +
Sbjct: 1122 SAAPEPHPSTSTAQ-PVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQP--V 1178

Query: 1732 DAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKA 1791
             ++P +      ++ S+V   P++  P +   Q S   + P   +P + A      N+ +
Sbjct: 1179 TSEPTSQVTRGRKSRSSV-KTPETVVPTALELQPSTSTDRPVTSEPTSQA-TRGRKNRSS 1236

Query: 1792 EAAPESQPPASEDLE----VDPPVAAKDK-KPNKSKRSKTPVQAAAVSIVEKPVTRKSER 1846
               PE   P + +L+     D PV ++   +  + +++++ V+     +   P  R S  
Sbjct: 1237 VKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTS 1296

Query: 1847 IDREKLKRSNSPRGEAQKLLELKMEAEKITRTASK-NSAADLEHPEPSLPLSRTRRRNVR 1905
             DR    +  S    ++  +      E +  TA +   +   + P    P SRT R   R
Sbjct: 1297 TDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRS--R 1354

Query: 1906 SVYATMGDHENRSPV------KEPVEQP-------RVTRKRLERELQEA--AAVPTTPRR 1950
            +  +++ + E+  P+          EQP       R TR R  R   +     VPT P+ 
Sbjct: 1355 TNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKL 1414

Query: 1951 GRPPKTRRRADEEEENEA---KEPAETLKPPEGW--RSPRSQKTAAGGGP-------QGK 1998
                 T +    E  ++A   +    ++K PE     +P  Q + +   P       Q  
Sbjct: 1415 EPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQAT 1474

Query: 1999 KGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNP---- 2054
            +G+ + +     PE      P++    S+ +P  +E    S   R RK+  + K P    
Sbjct: 1475 RGRTD-RSSVKTPETVVPTAPELQASASTDQPVTSEPT--SRTTRGRKNRSSVKTPETVV 1531

Query: 2055 ---PETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKS----------ASLKNVDAAVS 2101
               PE  P    ++   PE  S++ RGR+  S +   +S          ++ +N      
Sbjct: 1532 PAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPE 1591

Query: 2102 PRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPD-------KEPEKEDVS 2154
            P   A +     S V    P    +P+     S+     PV P        ++  +  V 
Sbjct: 1592 PTSRATRCRTNRSSVKTPEPVVPTAPEPHPTTST---DQPVTPKLTSRATRRKTNRSSVK 1648

Query: 2155 ASGP-SPEATQLAKQMELEQAV--EHIAK------LAEASASAAYKADAPEGLAPEDRDK 2205
               P  P A+ L      +Q+V  E IA+      L  ++  A      PE  +P   D+
Sbjct: 1649 TPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEFQSPVTTDQ 1708

Query: 2206 PAHQASETE--------LAAAIGSIINDISGEPENFPAPPP------------YPGESQT 2245
            P      T+         A   GS+   I  +P + P  P                ES T
Sbjct: 1709 PISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQRWGAVRAAESLT 1768

Query: 2246 DLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNS 2305
             +  PA  Q L       ET    S I + E A  S   P   P  S       ++R  S
Sbjct: 1769 AIPEPASPQLL-------ETPIHASQIQKVEPAGRSRFTPELQPKAS-------QSRKRS 1814

Query: 2306 SETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGE 2365
              T  S P  K  +  EV+        QKT                    + E  +   E
Sbjct: 1815 LATMDSPPHQKQPQRGEVS--------QKTV------------------IIKEEEEDTAE 1848

Query: 2366 SPAANEGTTVQHPEAPQEEKQSEKPHSTPPQS 2397
             P   E      P   + ++  E+P+  P +S
Sbjct: 1849 KPGKEEDVVTPKPGKRKRDQAEEEPNRIPSRS 1880



 Score = 84.0 bits (206), Expect = 3e-15
 Identities = 243/1136 (21%), Positives = 384/1136 (33%), Gaps = 185/1136 (16%)

Query: 1963 EEENEAKEPAET--------LKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATR--PE 2012
            E E+   +P +T        L PP      +  ++     P G +G+    VD     P+
Sbjct: 759  ESEDSETQPFDTHLEAYGPCLSPPRAIPGDQHPESPVHTEPMGIQGRGRQTVDKVMGIPK 818

Query: 2013 ATTE-VGPQIGVKESSME---PKAAEEEAGSEQ--------------KRDRKDAGTDKNP 2054
             T E VGP+ G  E   E   P+   +  G E+               RD +   +DKN 
Sbjct: 819  ETAERVGPERGPLERETEKLLPERQTDVTGEEELTKGKQDREQKQLLARDTQRQESDKNG 878

Query: 2055 PETAP--------VEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAA 2106
               +P        VE+   +   EK  + +   S+     V++  + +  D A       
Sbjct: 879  ESASPERDRESLKVEIETSEEIQEKQVQKQTLPSKAFEREVERPVANRECDPA------- 931

Query: 2107 AQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPS----PEA 2162
                E E  V  V  E+     + +G S   K     P  EP        GP+    P  
Sbjct: 932  ----ELEEKVPKVILERDTQRGEPEGGSQDQKGQASSPTPEPGVGAGDLPGPTSAPVPSG 987

Query: 2163 TQLAKQMELEQAVEHIAKLAEASASAAYKAD---APEGLAPEDRDKPAHQASETELAAAI 2219
            +Q   +        H   L       A KA    A E ++  D++ P      T   A  
Sbjct: 988  SQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEA-- 1045

Query: 2220 GSIINDISGEPENFPAPP--PYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEA 2277
                          PAPP  P   +SQ  L PP     L PS +         G  E   
Sbjct: 1046 --------------PAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPE 1091

Query: 2278 ATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTR 2337
            A  SS      P P       K +R      + + PE   S      +    K   + TR
Sbjct: 1092 APLSSELEPFHPKPKI--RTRKSSRMTPFPATSAAPEPHPSTSTAQPVT--PKPTSQATR 1147

Query: 2338 SRRKRNTNKKVVAPVESHVPESNQAQG-ESPAANEGT-----------TVQHPEAPQEEK 2385
            SR  R ++ K   PV    PE   +   + P  +E T           +V+ PE      
Sbjct: 1148 SRTNR-SSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTA 1206

Query: 2386 QSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQ 2445
               +P ++  +  TS+ +   +T       SV+   P   + P   P      PV  EP 
Sbjct: 1207 LELQPSTSTDRPVTSEPTS-QATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPT 1265

Query: 2446 ARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQ 2505
             +        S   TP  +P +P       TA +L P  ++       P ++ T   T  
Sbjct: 1266 YQATRGRKNRSSVKTP--EPVVP-------TAPELRPSTSTDRPVTPKPTSRTTRSRTNM 1316

Query: 2506 EEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAA 2565
               +   T  P  P      ++  S+ST + +   PK  S T+ + T++ +++  P S  
Sbjct: 1317 SSVKTPETVVPTAP------ELQISTSTDQPV--TPKPTSRTTRSRTNM-SSVKNPESTV 1367

Query: 2566 PCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRM 2625
            P   E  PP   +++P+  +     T   + ++S        E + P  APK+    S  
Sbjct: 1368 PIAPEL-PPSTSTEQPVTPEPTSRATRGRKNRSS----GKTPETLVPT-APKLEPSTS-- 1419

Query: 2626 PVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVST 2685
                     Q +T  +P  Q   G  +  +     ++VP      P   S +T + +   
Sbjct: 1420 -------TDQPVT-PEPTSQATRGRTNRSSVKTPETVVPTAPELQP---STSTDQPVTPE 1468

Query: 2686 PAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVT--VTA 2743
            P       +   + +  P  V+ T           AP  + A+AS      S  T   T 
Sbjct: 1469 PTSQATRGRTDRSSVKTPETVVPT-----------AP-ELQASASTDQPVTSEPTSRTTR 1516

Query: 2744 GAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSG 2803
            G    +S     T  TV  A   + PST   Q  +    SR             A  G  
Sbjct: 1517 GRKNRSS---VKTPETVVPAAPELQPSTSTDQPVTPEPTSR-------------ATRGRT 1560

Query: 2804 AGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTA 2863
                V T E +V ++   Q +    ++   ++  P + A      +S  K+   P+ V  
Sbjct: 1561 NRSSVKTPESIVPIAPELQPSTSRNQL---VTPEPTSRATRCRTNRSSVKT---PEPVV- 1613

Query: 2864 SQPPSKGPQAPAGYANVATHS--TLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVST 2921
                   P AP  +   +T    T  LT++        SSVK  +P   +P    L   T
Sbjct: 1614 -------PTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKP--VEPAASDLEPFT 1664

Query: 2922 PVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGST 2981
            P  Q  T + + QG  +  +       +    V T  +   PVT   +    +P    S 
Sbjct: 1665 PTDQSVTPEAIAQGGQSKTL---RSSTVRAMPVPTTPEFQSPVTTD-QPISPEPITQPSC 1720

Query: 2982 LTPHHPPALPSKLPTEVNHVP-SGPSIPADRTVSH-----LAAAKLDAHSPRPSGP 3031
            +        P  L   ++H P S P  P  +   +     + AA+     P P+ P
Sbjct: 1721 IKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQRWGAVRAAESLTAIPEPASP 1776



 Score = 73.2 bits (178), Expect = 5e-12
 Identities = 201/1026 (19%), Positives = 349/1026 (34%), Gaps = 125/1026 (12%)

Query: 1656 KTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMM 1715
            +TTG  T++ P   E    +P  + E     ++P    +E       PP A P  +    
Sbjct: 738  QTTG--TLDEPW--EVLATQPFCLRESEDSETQPFDTHLEAYGPCLSPPRAIPGDQHPES 793

Query: 1716 PAGVEE-GSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKS----EEAN 1770
            P   E  G  G     +D     P  +  +      P    T+ L    Q      EE  
Sbjct: 794  PVHTEPMGIQGRGRQTVDKVMGIPKETAERVGPERGPLERETEKLLPERQTDVTGEEELT 853

Query: 1771 EPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQA 1830
            + K ++      A     Q+++   ES  P  +   +   +   ++   K  + +T    
Sbjct: 854  KGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVEIETSEEIQEKQVQKQTLPSK 913

Query: 1831 AAVSIVEKPVTRK-------SERIDREKLKRS---NSPRGEAQKLLELKMEAEKITRTAS 1880
            A    VE+PV  +        E++ +  L+R      P G +Q   + K +A   T    
Sbjct: 914  AFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQ---DQKGQASSPTPEPG 970

Query: 1881 KNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHEN-----RSPVKEPVEQPRVTRK--R 1933
               A DL  P  S P+    +   R    +   H+      + P  E   + R   K  R
Sbjct: 971  V-GAGDLPGP-TSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSR 1028

Query: 1934 LERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGG 1993
             ++E  +A   PT P    PP+    +  ++      P   L P      P  +KT   G
Sbjct: 1029 GDQESPDACLPPTVPEAPAPPQKPLNSQSQKH---LAPPPLLSPLLPSIKPTVRKTRQDG 1085

Query: 1994 GPQGKKG---------KNEPKVDATR-----PEATTEVGPQIGVKESSMEPKAAEEEAGS 2039
              +  +            +PK+   +     P   T   P+     S+ +P     +  S
Sbjct: 1086 SQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQP--VTPKPTS 1143

Query: 2040 EQKRDRKDAGTDKNP-------PETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSAS 2092
            +  R R +  + K P       PE  P    ++    E  S+  RGR   S +   ++  
Sbjct: 1144 QATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVV 1203

Query: 2093 LKNVDAAVS----------PRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQ--LKSD 2140
               ++   S          P   A +  +  S V    P    +P+ +   S+   + S+
Sbjct: 1204 PTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSE 1263

Query: 2141 PVDPDKEPEKEDVSASGPS---PEATQLAKQMELEQAV---------EHIAKLAEASASA 2188
            P        K   S   P    P A +L      ++ V              ++      
Sbjct: 1264 PTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPE 1323

Query: 2189 AYKADAPEGLAPEDRDKPA---HQASETELAAAIGSIINDISGEPENFPAPPPYPGESQT 2245
                 APE       D+P      +  T     + S+ N  S  P     PP    E   
Sbjct: 1324 TVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPV 1383

Query: 2246 DLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEA-RGN 2304
              +P + A   + +    +T        ET   T     P  + D    P  T +A RG 
Sbjct: 1384 TPEPTSRATRGRKNRSSGKTP-------ETLVPTAPKLEPSTSTDQPVTPEPTSQATRGR 1436

Query: 2305 SSETSHSVPEAKGSKEVEV---TLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQ 2361
            ++ +S   PE       E+   T   +    + T+++ R R     V  P E+ VP + +
Sbjct: 1437 TNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTP-ETVVPTAPE 1495

Query: 2362 AQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVE--E 2419
             Q  + A+ +      P +     +  +     P++      ++  + ++ Q ++ E   
Sbjct: 1496 LQ--ASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTS 1553

Query: 2420 RTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPV-------TPPSDPSIPIPTL 2472
            R     +    +  P    P+  E Q     + ++  +P        T  S    P P +
Sbjct: 1554 RATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVV 1613

Query: 2473 PSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQ-STPSPALPPDTKASDVDTSS 2531
            P  TA +  P  ++     Q    K+T   TR++  R+   TP P  P    ASD++  +
Sbjct: 1614 P--TAPEPHPTTST----DQPVTPKLTSRATRRKTNRSSVKTPKPVEP---AASDLEPFT 1664

Query: 2532 STLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVT 2591
             T + +  +       S T  S +T  A PV   P        PV + +P+  +   P+T
Sbjct: 1665 PTDQSVTPEAIAQGGQSKTLRS-STVRAMPVPTTPEFQS----PVTTDQPISPE---PIT 1716

Query: 2592 NNSEIQ 2597
              S I+
Sbjct: 1717 QPSCIK 1722



 Score = 50.1 bits (118), Expect = 4e-05
 Identities = 132/617 (21%), Positives = 208/617 (33%), Gaps = 101/617 (16%)

Query: 2895 ASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVL---TQGINTPPVLVHNQLVLTP 2951
            AS + ++ K  R   E P+   L  + P       K L   +Q    PP L+     L P
Sbjct: 1017 ASRIRAAEKVSRGDQESPDAC-LPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSP---LLP 1072

Query: 2952 SIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHP-PALPSKLPTEVNHVPSGPSIPAD 3010
            SI  T +K     T +  ++    A L S L P HP P + ++  + +   P+  + P  
Sbjct: 1073 SIKPTVRK-----TRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEP 1127

Query: 3011 RTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVPQFISS 3070
               +  A         +P  P P+S    +  S T  +++ T   V+  A    P+   S
Sbjct: 1128 HPSTSTA---------QPVTPKPTS---QATRSRTNRSSVKTPEPVVPTA----PELQPS 1171

Query: 3071 IHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIE 3130
               +Q V   P   T  V+    S+  V+     +P+    ++P          +P    
Sbjct: 1172 TSTDQPVTSEP---TSQVTRGRKSRSSVKTPETVVPT-ALELQPSTSTDRPVTSEPTSQA 1227

Query: 3131 VRAPQRAS---TPQP----APAGVPALASQHPPEEEVHYHLPVARAT-APVQSEVLVMQS 3182
             R  +  S   TP+P    AP   P+ ++  P   E  Y     R   + V++   V+ +
Sbjct: 1228 TRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPT 1287

Query: 3183 EYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAA 3242
               L P T        V P  T+ + + R     VK P  +  P  P  + + + D    
Sbjct: 1288 APELRPST---STDRPVTPKPTSRTTRSRTNMSSVKTPE-TVVPTAPELQISTSTDQPVT 1343

Query: 3243 PTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGEL 3302
            P PT                    +R    +  N    +P+ P +               
Sbjct: 1344 PKPTSRTT---------------RSRTNMSSVKNPESTVPIAPEL--------------- 1373

Query: 3303 FQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQP 3362
                         PP+  T        +       K  + G  PE      P+   ST  
Sbjct: 1374 -------------PPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTST 1420

Query: 3363 AQPAPPCPPSQLGQPGQPPSS-KMPQVSQEAKGTQTGVEQPRLPAGPANRP--PEPHTQV 3419
             QP  P P SQ  +     SS K P+       T         P+   ++P  PEP +Q 
Sbjct: 1421 DQPVTPEPTSQATRGRTNRSSVKTPE-------TVVPTAPELQPSTSTDQPVTPEPTSQA 1473

Query: 3420 QRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQ 3479
             R + +      P  V V   P+L  S  T           TT G      +  P T   
Sbjct: 1474 TRGRTDRSSVKTPETV-VPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVP 1532

Query: 3480 PAPKQDSSPHLTSQRPV 3496
             AP  +  P  ++ +PV
Sbjct: 1533 AAP--ELQPSTSTDQPV 1547



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 68/294 (23%), Positives = 98/294 (33%), Gaps = 72/294 (24%)

Query: 3218 KVPPASKAPQQPGKEAA-----KTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTV 3272
            K+PPA KA +    E       ++PDA   PT   AP P   PL + +        +L+ 
Sbjct: 1010 KMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLS- 1068

Query: 3273 TPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTH------TQFP 3326
                     PL P +  T        S E  +     ++  +HP  ++        T FP
Sbjct: 1069 ---------PLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFP 1119

Query: 3327 AASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSS-KM 3385
            A S+                       P+P  ST  AQP  P P SQ  +     SS K 
Sbjct: 1120 ATSAA----------------------PEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKT 1157

Query: 3386 PQVSQEAKGTQTGVEQPRLPAGPANRP---------PEPHTQVQRAQAETGPTSFPS--- 3433
            P              +P +P  P  +P          EP +QV R +        P    
Sbjct: 1158 P--------------EPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVV 1203

Query: 3434 PVSVSMKPDLPVSLPTQTAPKQPLF--VPTTSGPSTPPGLVLPHTEFQPAPKQD 3485
            P ++ ++P      P  + P           S   TP  +V    E QP+   D
Sbjct: 1204 PTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTD 1257



 Score = 42.7 bits (99), Expect = 0.007
 Identities = 70/282 (24%), Positives = 100/282 (35%), Gaps = 33/282 (11%)

Query: 3221 PASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQG 3280
            P   +  Q G+ ++ TP+        P P   PVP            R   V+P    +G
Sbjct: 951  PEGGSQDQKGQASSPTPEPGVGAGDLPGPTSAPVP-----SGSQSGGRGSPVSPRRHQKG 1005

Query: 3281 L--PLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHT--QFPAASSVGLPSR 3336
            L     PP      ++         QE          P A L  T  + PA     L S+
Sbjct: 1006 LLNCKMPPAEKASRIRAAEKVSRGDQE---------SPDACLPPTVPEAPAPPQKPLNSQ 1056

Query: 3337 TKTAAQGPPPEGEPLQP--PQPVQSTQP--AQPAPPCPPSQLGQPGQP-PSSKMPQVSQE 3391
            ++     PPP   PL P     V+ T+   +Q AP  P S   +P  P P  +  + S+ 
Sbjct: 1057 SQKHL-APPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRM 1115

Query: 3392 AKGTQTGVEQPRLPAGPANRP--PEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPT 3449
                 T       P+    +P  P+P +Q  R++        P PV V   P+L  S  T
Sbjct: 1116 TPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPV-VPTAPELQPSTST 1174

Query: 3450 -QTAPKQPLFVPT-----TSGPSTPPGLVLPHTEFQPAPKQD 3485
             Q    +P    T      S   TP  +V    E QP+   D
Sbjct: 1175 DQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTSTD 1216



 Score = 39.3 bits (90), Expect = 0.073
 Identities = 103/492 (20%), Positives = 168/492 (34%), Gaps = 82/492 (16%)

Query: 2247 LQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSS 2306
            L+PP   + L P       D+ +  IL  +   +  R  V+ P  S GP   +E      
Sbjct: 101  LRPP---KVLSPGVSHRLRDQEL--ILFADLLCQYHRLDVSLPFVSRGPLTVEET----- 150

Query: 2307 ETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRK-----RNTNKKVVAPV---ESHVP- 2357
                  P  +G  + +  L+ +D   +    S R+     R T+  V+ P    E H P 
Sbjct: 151  ------PRVQGETQPQRLLLAEDSEEEVDFLSERRMVKKSRTTSSSVIVPESDEEGHSPV 204

Query: 2358 --------------ESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLS 2403
                          +++  +G+ PA  E ++     A  E KQSE    T  Q    D  
Sbjct: 205  LGGLGPPFAFNLNSDTDVEEGQQPATEEASSAARRGATVEAKQSEAEVVTEIQ-LEKDQP 263

Query: 2404 KIPSTENSSQ------------EISVEERTP----TKASVPPDLPPPPQPAPVDEEPQAR 2447
             +   +N ++             + +E   P    +   V  D  PP +PA V  E   R
Sbjct: 264  LVKERDNDTKVKRGAGNGVVPAGVILERSQPPGEDSDTDVDDDSRPPGRPAEVHLE---R 320

Query: 2448 FRVHSIIESD--------PVTPPSDPSIPIPTLPSV-TAAKLSPPVASGGIPHQSPPTKV 2498
             +    I+SD        P TP   P         V T    +P +A          T V
Sbjct: 321  AQPFGFIDSDTDAEEERIPATPVVIPMKKRKIFHGVGTRGPGAPGLAHLQESQAGSDTDV 380

Query: 2499 TEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAI 2558
             E    Q  P  +S  S  +  DT   +  +++ TL  +      +             +
Sbjct: 381  EEGKAPQAVPLEKSQASMVINSDTDDEEEVSAALTLAHLKESQPAIWNRDAEEDMPQRVV 440

Query: 2559 AEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKI 2618
                S      ++     + + P+E + A  + ++++I+A   LV A  EK  P      
Sbjct: 441  LLQRSQTTTERDSDTDVEEEELPVENREA-VLKDHTKIRA---LVRAHSEKDQPPFGDSD 496

Query: 2619 TSV-ISRMPVSIDLENSQKITLAK---------PAPQTLTGLVSALTGLVNVSLVPVNAL 2668
             SV   +    I LE SQ  T            P    +  +      +   +   V A+
Sbjct: 497  DSVEADKSSPGIHLERSQASTTVDINTQVEKEVPPGSAIIHIKKHQVSVEGTNQTDVKAV 556

Query: 2669 KGPVKGSVTTLK 2680
             GP K  V +L+
Sbjct: 557  GGPAKLLVVSLE 568



 Score = 34.7 bits (78), Expect = 1.8
 Identities = 30/133 (22%), Positives = 66/133 (49%), Gaps = 24/133 (18%)

Query: 981  LEARKRRFADSNLKAEKQKPE---VKKSSPEMEDARVLSKKQPDVSSREVILLREGEAER 1037
            ++ R R+  D  +   K+  E    ++   E E  ++L ++Q DV+  E   L +G+ +R
Sbjct: 802  IQGRGRQTVDKVMGIPKETAERVGPERGPLERETEKLLPERQTDVTGEEE--LTKGKQDR 859

Query: 1038 KPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVE 1097
            +  +K++L R++++ + D+    ASP+  +E   + + +                 E ++
Sbjct: 860  E--QKQLLARDTQRQESDKNGESASPERDRESLKVEIET----------------SEEIQ 901

Query: 1098 NQEVQSKKPIPSK 1110
             ++VQ K+ +PSK
Sbjct: 902  EKQVQ-KQTLPSK 913



 Score = 32.7 bits (73), Expect = 6.8
 Identities = 76/387 (19%), Positives = 145/387 (37%), Gaps = 39/387 (10%)

Query: 1537 EQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANS-----TTDSIQEPVVLFHSRFMELT 1591
            E   +RL   E  EE+ DF+S R   K++   ++S     + +    PV+          
Sbjct: 156  ETQPQRLLLAEDSEEEVDFLSERRMVKKSRTTSSSVIVPESDEEGHSPVLGGLGPPFAFN 215

Query: 1592 RMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAP 1651
                 + E+ Q+P   E+         T E+  +  ++E+ T   +      V   ++  
Sbjct: 216  LNSDTDVEEGQQP-ATEEASSAARRGATVEA--KQSEAEVVTEIQLEKDQPLVKERDN-D 271

Query: 1652 SALEKTTGDKTVEAPLVTEEKTV----EPATVSEEAKPASEPAPAPVEQLEQVDLPPGAD 1707
            + +++  G+  V A ++ E            V ++++P   PA   +E+ +       +D
Sbjct: 272  TKVKRGAGNGVVPAGVILERSQPPGEDSDTDVDDDSRPPGRPAEVHLERAQPFGF-IDSD 330

Query: 1708 PDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGA------SFSQAESNVDPEPDSTQPLSK 1761
             D E   +PA         +  +       PGA        SQA S+ D E +   P + 
Sbjct: 331  TDAEEERIPATPVVIPMKKRKIFHGVGTRGPGAPGLAHLQESQAGSDTDVE-EGKAPQAV 389

Query: 1762 PAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPA-SEDLEVDPP---VAAKDKK 1817
            P +KS+ +    ++  D   + E  A        ESQP   + D E D P   V  +  +
Sbjct: 390  PLEKSQASMVINSDTDD---EEEVSAALTLAHLKESQPAIWNRDAEEDMPQRVVLLQRSQ 446

Query: 1818 PNKSKRSKTPVQAAAVSIVEKPVTRKS----ERIDREKLKRSNSPRGEAQKLLE------ 1867
                + S T V+   + +  +    K       + R   ++   P G++   +E      
Sbjct: 447  TTTERDSDTDVEEEELPVENREAVLKDHTKIRALVRAHSEKDQPPFGDSDDSVEADKSSP 506

Query: 1868 -LKMEAEKITRTASKNSAADLEHPEPS 1893
             + +E  + + T   N+  + E P  S
Sbjct: 507  GIHLERSQASTTVDINTQVEKEVPPGS 533


>gi|239743293 PREDICTED: mucin 12 [Homo sapiens]
          Length = 5478

 Score = 95.5 bits (236), Expect = 9e-19
 Identities = 381/2011 (18%), Positives = 643/2011 (31%), Gaps = 249/2011 (12%)

Query: 1619 TPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPAT 1678
            T +S P + D+    P +   P     T  S PS+   T    +      +EE T   ++
Sbjct: 1582 TFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSS 1641

Query: 1679 VSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTP 1738
                         A    + +    P +    E   +P         ++     + P +P
Sbjct: 1642 PGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSP 1701

Query: 1739 GASFSQAESNVDP-EPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPES 1797
              + S A +       +ST   S+P      A       P  + ++    +         
Sbjct: 1702 DTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGVSQESTASHSSPGSTDTTL 1761

Query: 1798 QPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPV-TRKSERIDREKLKRSN 1856
             P ++    + P        P  ++ +  P    A  ++E       S       L  + 
Sbjct: 1762 SPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSSTGSPHTTLSPAG 1821

Query: 1857 SPRGEAQKLLELKMEAEKITRTASKNSAA---DLEHPEPSLPLSRTRRRNVRSVYATMGD 1913
            S   + +        + K T  A   + +   +L       P S T   +  +   T+G 
Sbjct: 1822 STTRQGESTTFQSWPSSKDTMPAPPTTTSAFVELSTTSHGSP-SSTPTTHFSASSTTLGR 1880

Query: 1914 HENRSPV-KEPVEQ---PRVTRKRLERELQEAAAVPTTPRRGRP---PKTRRRADEEEEN 1966
             E  + V   PV     P   R      ++E+ A  ++P   +    P++   +   EE+
Sbjct: 1881 SEESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSPGSTQTMHFPESSTASGRSEES 1940

Query: 1967 EAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKES 2026
                 + T        SP S  +A    P               P+++T  G      E 
Sbjct: 1941 RTSHSSTT----HTISSPPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRS----EE 1992

Query: 2027 SMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLA 2086
            S    ++++  G+     R           T+P+     +      S +  G S  S   
Sbjct: 1993 STASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTF 2052

Query: 2087 VDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGL--------SSQLK 2138
                +S ++    +SP    +     ES      P  + +    D          S+   
Sbjct: 2053 ---HSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSRHSTTSH 2109

Query: 2139 SDPVDPDKEPEKEDVSASGPSPEATQL-AKQMELEQAVEHIAKLA-----EASASAAYKA 2192
            S P   D        + SGPS E+T   +     + A+   +  A     E++   +   
Sbjct: 2110 SSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFHSSPG 2169

Query: 2193 DAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAG 2252
                 L P+         + T + ++ GS    +S      PA    PG     LQ  + 
Sbjct: 2170 STHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLS------PASSTSPG-----LQGEST 2218

Query: 2253 AQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSV 2312
            A    P+          +     E +T   R P + P      + T       S   HS 
Sbjct: 2219 AFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSS 2278

Query: 2313 PEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGE------- 2365
            P+A G+     +      GR ++T SR    + +    P  +  P  ++A          
Sbjct: 2279 PDASGT--TPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRS 2336

Query: 2366 -----SPAANEGTTVQHPEAPQEEKQSEKPHST--PPQSCTSDLSK----IPSTENSSQE 2414
                 SPA+     V   E+     Q    HST  P  + T  LS+    + S+   S E
Sbjct: 2337 PTTTLSPASMTSLGVGE-ESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTE 2395

Query: 2415 ISVEERTPTKASVPPDLPPP--PQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTL 2472
             +V  RTPT  SV  + P     +PA             S +  +    P  P+     L
Sbjct: 2396 TTVFPRTPT-TSVRGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGL 2454

Query: 2473 P-SVTAAKLSP-----PVASGGI-PHQSPPTKVTEWITRQEEP---RAQSTPSPALPPDT 2522
            P ++T A L       P +SG      SP    T  +  +  P      ST +  LP   
Sbjct: 2455 PATLTTADLGEESTTFPSSSGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSP 2514

Query: 2523 KASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAA---------PCLHEAPP 2573
                +   S+T       P+   AT   +T+ ++ ++E  S +             ++  
Sbjct: 2515 TTPSLSEKSTT---FYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTT 2571

Query: 2574 PPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVA---------PVIAPKITSVISR 2624
             P  S+      ++P  T+ + + AS       +E              ++P  T+ +S 
Sbjct: 2572 TPGLSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSF 2631

Query: 2625 MPVSIDLENS--QKITLAKPAPQTLTGLVSA------LTGLVNVSLVPVNALKGPVKGSV 2676
               S    +S     T   P   T +G+V A       TG    +L P ++    ++G  
Sbjct: 2632 GQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGES 2691

Query: 2677 TTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTT-------------PVNATVG------- 2716
            TT +    T     +    P +  T PV   TT             P ++T         
Sbjct: 2692 TTFQ----THPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKST 2747

Query: 2717 TVNAAPGTVNAAASAVNATASA-VTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQ 2775
              +++P       S+ ++T S     T   ++  S  +T   G+ T  G   A +T    
Sbjct: 2748 IFHSSPDASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSS 2807

Query: 2776 RASANENSRFHPGSMPV--IDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAK 2833
              S    +   P SM    + +    + S  G   +T      +S +   T G    S  
Sbjct: 2808 PRS--PTTTLSPASMTSLGVGEESTTSRSQPGSTHST------VSPASTTTPGLSEESTT 2859

Query: 2834 ISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTY 2893
            +    P S     F +S + S    +  T    P+        +   +T S L   +  +
Sbjct: 2860 VYSSSPGSTETTVFPRSTTTSVRGEEPTTFHSRPAS--THTTLFTEDSTTSGLTEESTAF 2917

Query: 2894 NASPVISSVKADRP-SLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLV--LT 2950
              SP  +S +   P +L   +    S + P + G T   L+   +T   LV       L+
Sbjct: 2918 PGSP--ASTQTGLPATLTTADLGEESTTFPSSSGSTGTTLSPARSTTSGLVGESTPSRLS 2975

Query: 2951 PSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPAD 3010
            PS   T      P T  +  K         + T +  P  P    +      SG S  + 
Sbjct: 2976 PSSTETTTLPGSPTTPSLSEK---------STTFYTSPRSPDATLSPATTTSSGVSEESS 3026

Query: 3011 RTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTA-LSTNATVMLAAGIPVPQFIS 3069
             + S   +    A     +  G S  P ASH S  ++ A LS  +T   + G     F S
Sbjct: 3027 TSHSQPGSTHTTAFPDSTTTSGLSQEPTASHSSQGSTEATLSPGSTTASSLGQQSTTFHS 3086

Query: 3070 SIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPT---LPSITYSIRPEALHSPRAPLQP 3126
            S    ++ ++P  +IT          G V  +TPT     S+  ++ P +  S  A LQ 
Sbjct: 3087 SPGDTETTLLPDDTIT---------SGLVEASTPTHSSTGSLHTTLTPAS--STSAGLQE 3135

Query: 3127 QQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRL 3186
            +    ++   +S   P+P G  A                     APV+     + + Y  
Sbjct: 3136 ESTTFQSWPSSSDTTPSPPGTTA---------------------APVE-----VSTTYHS 3169

Query: 3187 HPYTVPRDVRIMVHPHVTAVSE---QPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAP 3243
             P + P         H +A S    +   +  V   P A+     P + A      +   
Sbjct: 3170 RPSSTPT-------THFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTT 3222

Query: 3244 TPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELF 3303
            +P  +       LP          +  T   S +     L+P    + GV    S     
Sbjct: 3223 SPISSGSTETTALPGSTTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGV----SEESTT 3278

Query: 3304 QEYRYGDIRTYHPPAQLT-----------HTQFPAASSVGLPSRTKTAAQGP-------- 3344
               R G   T   P   T           H+   +  +   P  T  ++ GP        
Sbjct: 3279 SHSRPGSTHTTAFPGSTTMPGVSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSG 3338

Query: 3345 PPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRL 3404
            P   E    P    ++   + + P   S     G P ++  P  S   +G  T  +    
Sbjct: 3339 PGSTETTLLPDNTTASGLLEASTPVHSS----TGSPHTTLSPAGSTTRQGESTTFQS--W 3392

Query: 3405 PAGPANRPPEPHTQVQRAQAET----GPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVP 3460
            P      P  P T     +  T     P+S P+    +    L  S  + T    P+   
Sbjct: 3393 PNSKDTTPAPPTTTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATA 3452

Query: 3461 TTSGP--STPPGLVLPHTEFQPAPKQDSSPH 3489
            TT  P  ST  GLV   T +  +P    + H
Sbjct: 3453 TTPSPARSTTSGLVEESTTYHSSPGSTQTMH 3483



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 408/2114 (19%), Positives = 657/2114 (31%), Gaps = 332/2114 (15%)

Query: 1620 PESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATV 1679
            PES+  +  SE ++    G  + T  +  S  +AL  T+   ++ +   T  +     + 
Sbjct: 517  PESSTTSGHSE-ESATFHGSTTHTKSSTPSTTAALAHTSYHSSLGSTETTHFRDSSTISG 575

Query: 1680 SEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAA-MMPAGVEEGSSGDQPPYLDAKPPTP 1738
              E   AS  +P   + +    LP G+ P        P+ +  GS   +   L      P
Sbjct: 576  RSEESKASHSSP---DAMATTVLPAGSTPSVLVGDSTPSPISSGSM--ETTALPGSTTKP 630

Query: 1739 GASFSQAESNVDPE-PDSTQ-PLSKPAQKSEEANEPKAEKPDAT-------ADAEPDANQ 1789
            G S         P  PD+T  P S  +    E +     +P +T       +   P  +Q
Sbjct: 631  GLSEKSTTFYSSPRSPDTTHLPASMTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGLSQ 690

Query: 1790 KAEAAPESQPPASEDLE--------VDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPV- 1840
            ++ A+  S  P    L         + P       +P  ++ +  P    A  ++E  + 
Sbjct: 691  ESTASHSSPGPTDTTLSPGSTTASSLGPEYTTFHSRPGSTETTLLPDNTTASGLLEASMP 750

Query: 1841 TRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEP-------S 1893
               S R     L  + S   + +        + K TR A   + +    P         S
Sbjct: 751  VHSSTRSPHTTLSPAGSTTRQGESTTFHSWPSSKDTRPAPPTTTSAFVEPSTTSHGSPSS 810

Query: 1894 LPLSRTRRRNVRSVYATMGDHENRSPVK-EPVEQPRVTRKRLERELQEAAAVPTTPRRGR 1952
            +P +    R+  S         + SP   + +  P         E    +   TT     
Sbjct: 811  IPTTHISARSTTSGLVEESTTYHSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISS 870

Query: 1953 PPKTRRRADEEEENEAKEPAETLK---PPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDAT 2009
             P T     EE  +    P  T     P     S RS+++ A    Q   G       +T
Sbjct: 871  APSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARST 930

Query: 2010 RP----EATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDA--GTDKNPPET-APVEV 2062
                  E+TT       +   SME  A      +    +R      + ++P  T +P   
Sbjct: 931  TSVLLGESTTSP-----ISSGSMETTALPGSTTTPGLSERSTTFHSSPRSPATTLSPAST 985

Query: 2063 VEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPE 2122
                 + E  +   R  S ++    D + +       +S     + +    +    +   
Sbjct: 986  TSSGVSEESTTSRSRPGSTHTTAFPDSTTT-----PGLSRHSTTSHSSPGSTDTTLLPAS 1040

Query: 2123 KSESPQKEDGLSSQLKSDPVDPDKEP---------EKEDVSASGPSPEATQLAKQMELEQ 2173
             + S   ++  +S   S   D    P         ++     S P    T L        
Sbjct: 1041 TTTSGPSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFHSNPGSTHTTLFPDSTTSS 1100

Query: 2174 AVEHIAKLAEASASAAYKADAPEG-LAPEDRDKPAHQASETELAAAIGSIINDISGEPEN 2232
             +       EAS        +P   L+P     P  Q   T       S  +     P  
Sbjct: 1101 GI------VEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPAST-HTTPSPPST 1153

Query: 2233 FPAPPPY-------PGESQTDLQPPAGAQALQPSEEG--METDEAVSGILETEA-ATESS 2282
              AP          PG + T    PA +     SE+     +    SG   + A +T S 
Sbjct: 1154 ATAPVEESTTYHRSPGSTPTT-HFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSG 1212

Query: 2283 RPPVNAPDPSAGPTDTKEARGNS--------SETSHSVPEAKGSKEVEVTLVRKDKGRQK 2334
            R        S G T+     G++        S T +S P +  +     ++     G + 
Sbjct: 1213 RGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEES 1272

Query: 2335 TTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTT--VQHPEAPQEEKQSEKP-- 2390
            TT SR +  +    V+P  +  P  ++      +++ G+T     P +       E+P  
Sbjct: 1273 TT-SRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTTSVHGEEPTT 1331

Query: 2391 -HSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQ---- 2445
             HS P  + T+  ++  +T   ++E +    +P  AS    LP     A + EE      
Sbjct: 1332 FHSRPASTHTTLFTEDSTTSGLTEESTAFPGSP--ASTQTGLPATLTTADLGEESTTFPS 1389

Query: 2446 -----------ARFRVHSII-ESDP----------VTPPSDPSIP--------IPTLPSV 2475
                       AR     ++ ES P           T P  P+ P          T P  
Sbjct: 1390 SSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRS 1449

Query: 2476 TAAKLSPPVA-SGGIPHQSP--------------PTKVTEWITRQEEPRAQS----TPSP 2516
              A LSP    S G+  +S               P   T     QE   + S    T + 
Sbjct: 1450 PDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSDLSQEPTTSHSSQGSTEAT 1509

Query: 2517 ALPPDTKASDVDTSSSTLRK--------ILMDPKYVSATSVTST-------SVTTAIAEP 2561
              P  T AS +   S+T           +L D    S     ST       S+ T +   
Sbjct: 1510 LSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPA 1569

Query: 2562 VSAAPCLHE--------------APPPPVDSKKPLEEKTA----PPVTNNSEIQASEVLV 2603
             S +  L E               P PP  +  P+E  T     P  T  +   AS   +
Sbjct: 1570 SSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTL 1629

Query: 2604 AADKEKVAPVIAP-----------KITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVS 2652
               +E      +P             TSV+   P +  + +    T A P   T  GL  
Sbjct: 1630 GRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGLSE 1689

Query: 2653 ALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVN 2712
              T   +    P   L        +T  S VS  +   +   G  +    P +     V+
Sbjct: 1690 KSTTFYSSPRSPDTTLS-----PASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGVS 1744

Query: 2713 ATVGTVNAAPGTVNAAASAVNATASAV---------------TVTAGAVTAASGGVTATT 2757
                  +++PG+ +   S  + TAS++               T      T ASG + A+T
Sbjct: 1745 QESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEAST 1804

Query: 2758 GTVTMAGAVIAPSTKCKQRASANENSRFH--PGSMPVIDDRPADAGSGAGLRVNTSEG-- 2813
               +  G+     +         E++ F   P S   +   P    +   L   TS G  
Sbjct: 1805 PVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPSSKDTMPAPPTTTSAFVELST-TSHGSP 1863

Query: 2814 --VVLLSYSGQKTE-GPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKG 2870
                   +S   T  G    S  +   P A+A      +S +   V+  +   S P S  
Sbjct: 1864 SSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSPGSTQ 1923

Query: 2871 PQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVK 2930
                   +  +  S    T+ +     + S        +E+P   H S  +  T      
Sbjct: 1924 TMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSTATTHFPDS 1983

Query: 2931 VLTQGINTPPVLVHNQLVLTPSIV-----TTNKKLADPVTLKIETKVLQPANL-GSTLTP 2984
              T G +      H+    T +IV     TT+  L +  T  I +  ++   L GST TP
Sbjct: 1984 STTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTP 2043

Query: 2985 ---------HHPPALPSKLPTEVNHVPSG--------------------------PSIPA 3009
                     H  P  P+   +  +   SG                          P +  
Sbjct: 2044 GLSEKSTTFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSR 2103

Query: 3010 DRTVSHLAAAKLDAH----SPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIPVP 3065
              T SH +    D      S   SGP   S    S P ST  TALS  +T  L+ G    
Sbjct: 2104 HSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGST-DTALSPGSTTALSFGQEST 2162

Query: 3066 QFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQ 3125
             F SS     + + P      + + S + +   R+++ T              SPR  L 
Sbjct: 2163 TFHSSPGSTHTTLFP-----DSTTSSGIVEASTRVHSST-------------GSPRTTLS 2204

Query: 3126 PQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYR 3185
            P          AS+  P   G       HP         P + ATAPV+      +S   
Sbjct: 2205 P----------ASSTSPGLQGESTAFQTHPASTHTTPS-PPSTATAPVEESTTYHRSPGS 2253

Query: 3186 LHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTP 3245
                  P       H   + +      A G     P+S      G+  + T  ++ +P  
Sbjct: 2254 TPTTHFPASSTTSGHSEKSTIFHSSPDASGTT---PSSAHSTTSGRGESTT--SRISPGS 2308

Query: 3246 TPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQE 3305
            T         LP     P       T   S +     L+P  + + GV      GE    
Sbjct: 2309 TEITT-----LPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGV------GEESTT 2357

Query: 3306 YRYGDIRTYHPPAQLTHTQFPAASSV-GLPSRTKTAAQGPPPEGEP-LQPPQPVQSTQPA 3363
             R         P     T  PA+++  GL   + T     P   E  + P  P  S +  
Sbjct: 2358 SR-------SQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRTPTTSVRGE 2410

Query: 3364 QPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQ 3423
            +P             +P S+     ++++  +    E    P  PA+        +  A 
Sbjct: 2411 EPTT--------FHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTAD 2462

Query: 3424 AETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPK 3483
                 T+FPS    +     P    T     +    P+   PS+     LP +   P+  
Sbjct: 2463 LGEESTTFPSSSGSTGTTLSPARSTTSGLVGES--TPSRLSPSSTETTTLPGSPTTPSLS 2520

Query: 3484 QDSSPHLTSQRPVD 3497
            + S+   TS R  D
Sbjct: 2521 EKSTTFYTSPRSPD 2534



 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 393/2125 (18%), Positives = 633/2125 (29%), Gaps = 304/2125 (14%)

Query: 1569 ANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKD 1628
            A+STT    E   +FHS                  P              T   +P +  
Sbjct: 2735 ASSTTSGHSEKSTIFHS----------SPDASGTTPSSAHSTTSGRGESTTSRISPGS-- 2782

Query: 1629 SELKT-PPSVGPPSVTVV--TLESAPSALEKTTGDKTVEAPLVTEEKTV---EPATVSEE 1682
            +E+ T P S   P ++    T  S+P +   T    ++ +  V EE T    +P +    
Sbjct: 2783 TEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGSTHST 2842

Query: 1683 AKPASEPAPAPVEQLEQV-DLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGAS 1741
              PAS   P   E+   V    PG+    E  + P        G++P    ++P +   +
Sbjct: 2843 VSPASTTTPGLSEESTTVYSSSPGST---ETTVFPRSTTTSVRGEEPTTFHSRPASTHTT 2899

Query: 1742 FSQAESNVDP----------EPDSTQPLSKPAQKSEEANEPKAEKPDATADA-------- 1783
                +S               P STQ        + +  E     P ++           
Sbjct: 2900 LFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGTTLSPAR 2959

Query: 1784 EPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRK 1843
               +    E+ P    P+S +    P          KS    T  ++   ++   P T  
Sbjct: 2960 STTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATL--SPATTT 3017

Query: 1844 SERIDREKLKRSNSPRGEAQKLLELKMEAEKITR--TASKNSAADLEHP-EPSLPLSRTR 1900
            S  +  E     + P                +++  TAS +S    E    P    + + 
Sbjct: 3018 SSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTASHSSQGSTEATLSPGSTTASSL 3077

Query: 1901 RRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRA 1960
             +   + +++ GD E      + +    V           +     TP       T    
Sbjct: 3078 GQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASS----TSAGL 3133

Query: 1961 DEEEENEAKEPAE---TLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEV 2017
             EE       P+    T  PP    +P    T     P      + P    +    T   
Sbjct: 3134 QEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPS-----STPTTHFSASSTT--- 3185

Query: 2018 GPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKR 2077
               +G  E S    ++    G+     R         P T+P+     +      S +  
Sbjct: 3186 ---LGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTA 3242

Query: 2078 GRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQ--------- 2128
            G S  S       +S ++ D  +SP    +     ES      P  + +           
Sbjct: 3243 GLSEKSTTFY---SSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPG 3299

Query: 2129 -KEDGLSSQLKSDPVDPDKEPEKEDVSA---------SGPSPEATQLAKQMELEQAVEHI 2178
              ++  +S       D    P     S+         SGP    T L         +   
Sbjct: 3300 VSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSGPGSTETTLLPDNTTASGLLEA 3359

Query: 2179 AKLAEASASAAYKADAPEGLAPEDRDKPAHQA-----SETELAAAIGSIINDISGEPENF 2233
            +    +S  + +   +P G      +    Q+       T       S   ++S      
Sbjct: 3360 STPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGS 3419

Query: 2234 PAPPPYP-----------GESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESS 2282
            P+  P              E  T +     A A  PS     T    SG++E      SS
Sbjct: 3420 PSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTT----SGLVEESTTYHSS 3475

Query: 2283 RPPVNAPDPSAGPTDTKEARGNSSETSH--------SVPEAKGSKEVEVTLVRKDKGRQK 2334
              P +        +DT   RG  S TSH        S P    +   E T      G   
Sbjct: 3476 --PGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTA 3533

Query: 2335 TTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHST- 2393
            TT       T+ +      SH  +        PA +  T+V   E+      S    +T 
Sbjct: 3534 TTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARST-TSVLLGESTTSPISSGSMETTA 3592

Query: 2394 -PPQSCTSDLSKIPSTENSS-------------QEISVEERTPTKASVPPDLPPPPQPAP 2439
             P  + T  LS+  +T +SS                 V E + T  S P        P  
Sbjct: 3593 LPGSTTTPGLSEKSTTFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFP-- 3650

Query: 2440 VDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQS-PPTKV 2498
             D         HS              +P  T  S ++ + +   +S G    +  P   
Sbjct: 3651 -DSTTTPGLSRHSTTSHSSPGSTDTTLLPASTTTSGSSQESTTSHSSSGSTDTALSPGST 3709

Query: 2499 TEWITRQEEPRAQSTP----SPALPPDTKASDVDTSSSTLRKILMDPK-YVSATSVTSTS 2553
            T     QE     S+P    +   P  T +S +  +S+ +      P+  +S  S TS  
Sbjct: 3710 TALSFGQESTTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPG 3769

Query: 2554 VTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKT----APPVTNNSEIQASEVLVAADKEK 2609
            +        +     H  P PP  +  P+EE T    +P  T  +   AS       ++ 
Sbjct: 3770 LQGESTAFQTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKS 3829

Query: 2610 VAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALK 2669
                 +P  +                  T    A  T +G   + T  ++     +  L 
Sbjct: 3830 TIFHSSPDASG-----------------TTPSSAHSTTSGRGESTTSRISPGSTEITTLP 3872

Query: 2670 G--PVKGSVTTLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNA 2727
            G     G      +  S+P  P   L         P ++ +  V     T  + PG+ ++
Sbjct: 3873 GSTTTPGLSEASTTFYSSPRSPTTTL--------SPASMTSLGVGEESTTSRSQPGSTHS 3924

Query: 2728 AASAVNATASAVTVTAGAVTAASGGVTATT--GTVTMAGAVIAPSTKCKQRASANENSRF 2785
              S  + T   ++  +  V ++S G T TT     T         T    R ++   + F
Sbjct: 3925 TVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTTSVRREEPTTFHSRPASTHTTLF 3984

Query: 2786 HPGSMP--VIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAM 2843
               S    + ++  A  GS A  +      +       + T  P    +  +++ PA + 
Sbjct: 3985 TEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGTKLSPARST 4044

Query: 2844 DIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHST------LVLTAQTYNASP 2897
                    + S++ P S   +  P   P  P+      T  T        L+  T  +S 
Sbjct: 4045 TSGLVGESTPSRLSPSSTETTTLPG-SPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSG 4103

Query: 2898 VI--SSVKADRPSLEKPEPIHLSVST------PVT----QGGTVKVLTQGINTPPVLVHN 2945
            V   SS    +P          S +T      P T    QG T   L+ G  T   L   
Sbjct: 4104 VSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTTSHSSQGSTEATLSPGSTTASSLGQQ 4163

Query: 2946 QLVLTPSIVTTNKKLADPVTLK---IETKVLQPANLGS---TLTPHHPPA--LPSKLPTE 2997
                  S   T   L    T+    +E      ++ GS   TLTP    +  L  +  T 
Sbjct: 4164 STTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSTGLQEESTTF 4223

Query: 2998 VNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRA--------------SHPS 3043
             +   S  + P+  + + +       +  RPS    + F  +              S P 
Sbjct: 4224 QSWPSSSDTTPSPPSTTAVPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSSPG 4283

Query: 3044 STASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSH----------- 3092
            +T +    T +   +  G P    ISS   E + +  P S T T  LS            
Sbjct: 4284 ATGTALFPTRSATSVLVGEPTTSPISSGSTETTAL--PGS-TTTAGLSEKSTTFYSSPRS 4340

Query: 3093 ----LSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGV- 3147
                LS      +  +  S T   RP ++H+   P       V     AS   P      
Sbjct: 4341 PDTTLSPASTTSSGVSEESTTSHSRPGSMHTTAFPSSTTMPGVSQESTASHSSPGSTDTT 4400

Query: 3148 ----PALASQHPPEEEVHYHLPVARATAPVQSEVL---VMQSEYRLHPYTVPRDVRIMVH 3200
                   AS   PE    +  P +  T  +        ++++   +H  T          
Sbjct: 4401 LSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEASTPVHSST--------GS 4452

Query: 3201 PHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAK----AAPTPTPAPVPVPVP- 3255
            PH T               P  S   Q         P++K    A PT T A V +    
Sbjct: 4453 PHTTL-------------SPAGSTTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTS 4499

Query: 3256 --LPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRY----- 3308
               P+  P  H  A   T+  S +   +  +P    T       ++  L +E        
Sbjct: 4500 HGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSP 4559

Query: 3309 GDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPP 3368
            G  +T H P   T +     S+    S T T +  P      ++ P    S+ P   A  
Sbjct: 4560 GSTQTMHFPESNTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSS-PGSTATT 4618

Query: 3369 CPPSQLGQPGQPPSSKMPQVSQEAKGT----------------------QTGVEQPRLPA 3406
              P      G+   S     SQ+A GT                         +E   LP 
Sbjct: 4619 HFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPG 4678

Query: 3407 GPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGP- 3465
                    P    +     + P+S P+    +    L  S  + T    P+   TT  P 
Sbjct: 4679 STTT----PGLSEKSTTFHSSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPA 4734

Query: 3466 -STPPGLVLPHTEFQPAPKQDSSPH 3489
             ST  GLV   T +  +P    + H
Sbjct: 4735 RSTTSGLVEESTAYHSSPGSTQTMH 4759



 Score = 75.9 bits (185), Expect = 7e-13
 Identities = 281/1400 (20%), Positives = 447/1400 (31%), Gaps = 231/1400 (16%)

Query: 2206 PAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDL----QPPAGAQALQPSEE 2261
            P+H A+   +     S I   S E    P      G S+        P +  + L P+  
Sbjct: 240  PSHSATSVFVGEPKTSPITSASMETTALPGSTTTAGLSEKSTTFYSSPRSPDRTLSPART 299

Query: 2262 GMETDEAVSGILETEAATESSRPPVNA---PDPSAGPTDTKEARGNSSETSHSVPEAK-- 2316
                    SG+ E    + S   P +    PD +  P  ++E     S  SHS+P +   
Sbjct: 300  ------TSSGVSEKSTTSHSRPGPTHTIAFPDSTTMPGVSQE-----STASHSIPGSTDT 348

Query: 2317 ---------GSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESP 2367
                      S   E T      G  KTTR      T+  + A    H    +     SP
Sbjct: 349  TLSPGTTTPSSLGPESTTFHSSPGYTKTTRLPDNTTTSGLLEASTPVHSSTGSPHTTLSP 408

Query: 2368 AAN---EGTTVQHPEAPQEEKQSEKP--------------HSTPPQSCTSDLSKIPSTEN 2410
            +++   EG        P  +  S  P              HS+P  + T+  S   +T  
Sbjct: 409  SSSTTHEGEPTTFQSWPSSKDTSPAPSGTTSAFVKLSTTYHSSPSSTPTTHFSASSTTLG 468

Query: 2411 SSQEISVEERTPTKASVPPDLPPPPQPAPVD--EEPQARFR------VHSIIESDPVTPP 2462
             S+E +    +P   +     PPP + A     EE  A  R           ES   +  
Sbjct: 469  HSEESTPVHSSPVATAT---TPPPARSATSGHVEESTAYHRSPGSTQTMHFPESSTTSGH 525

Query: 2463 SDPSIPIPTLPSVTAAKLSPPVASGGIPHQS-----PPTKVTEWITRQE-EPRAQSTPSP 2516
            S+ S       S T  K S P  +  + H S       T+ T +        R++ + + 
Sbjct: 526  SEESATFH--GSTTHTKSSTPSTTAALAHTSYHSSLGSTETTHFRDSSTISGRSEESKAS 583

Query: 2517 ALPPDTKASDVDTSSSTLRKILMD--PKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPP 2574
               PD  A+ V  + ST   ++ D  P  +S+ S+ +T++  +  +P             
Sbjct: 584  HSSPDAMATTVLPAGSTPSVLVGDSTPSPISSGSMETTALPGSTTKPGL----------- 632

Query: 2575 PVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENS 2634
               S+K     ++P   + + + AS       +E       P  T               
Sbjct: 633  ---SEKSTTFYSSPRSPDTTHLPASMTSSGVSEESTTSHSRPGSTH-------------- 675

Query: 2635 QKITLAKPAPQTLTGLVSALT------GLVNVSLVPVNALKGPVKGSVTTLKS---LVST 2685
               T A P   T+ GL    T      G  + +L P +     +    TT  S      T
Sbjct: 676  ---TTAFPGSTTMPGLSQESTASHSSPGPTDTTLSPGSTTASSLGPEYTTFHSRPGSTET 732

Query: 2686 PAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGA 2745
               P N     +   + PV+  T   + T+    A   T    ++  ++  S+       
Sbjct: 733  TLLPDNTTASGLLEASMPVHSSTRSPHTTLSP--AGSTTRQGESTTFHSWPSSKDTRPAP 790

Query: 2746 VTAASGGVTATTGTVTMAGAVIAPSTKCKQRASAN----ENSRFH--PGSMPVIDDRPAD 2799
             T  S  V  +T +     ++  P+T    R++ +    E++ +H  PGS   +    +D
Sbjct: 791  PTTTSAFVEPSTTSHGSPSSI--PTTHISARSTTSGLVEESTTYHSSPGSTQTMHFPESD 848

Query: 2800 AGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQ-----IPPASAMDIEFQQSVSKS 2854
              SG G    TS      S +   +  P   SA + +       P S     F       
Sbjct: 849  TTSGRGEESTTSHS----STTHTISSAPSTTSALVEEPTSYHSSPGSTATTHF------- 897

Query: 2855 QVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEP 2914
               PDS T S    +  ++ A +++     T+VL A++   S ++               
Sbjct: 898  ---PDSSTTS---GRSEESTASHSSQDATGTIVLPARS-TTSVLLGE------------- 937

Query: 2915 IHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVL--TPSIVTTNKKLADPVTLKI-ETK 2971
               S ++P++ G        G  T P L         +P    T    A   +  + E  
Sbjct: 938  ---STTSPISSGSMETTALPGSTTTPGLSERSTTFHSSPRSPATTLSPASTTSSGVSEES 994

Query: 2972 VLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAH--SPRPS 3029
                +  GST    H  A P    T        P +    T SH +    D        +
Sbjct: 995  TTSRSRPGST----HTTAFPDSTTT--------PGLSRHSTTSHSSPGSTDTTLLPASTT 1042

Query: 3030 GPGPSSFPRASHPSS-TASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHS----I 3084
              GPS     SH SS +  TALS  +T  L+ G     F S+     + + P  +    I
Sbjct: 1043 TSGPSQESTTSHSSSGSTDTALSPGSTTALSFGQESTTFHSNPGSTHTTLFPDSTTSSGI 1102

Query: 3085 TQTVSLSHLSQGEVRMN----TPTLP-----SITYSIRPEALHSPRAPLQPQQIEVRAPQ 3135
             +  +  H S G  R      + T P     S  +   P + H+  +P       V   +
Sbjct: 1103 VEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTHPASTHTTPSPPSTATAPV---E 1159

Query: 3136 RASTPQPAPAGVP-------ALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHP 3188
             ++T   +P   P       +  S H  +  + +  P A  T P  +             
Sbjct: 1160 ESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTPSSAHSTTSGRGESTTS 1219

Query: 3189 YTVPRDVRIMVHPHVTAVSEQPRAADGVVKVP--------PASKAPQQPGKEAAKTPDAK 3240
               P    I   P  T       A+      P        PAS      G+E+  +    
Sbjct: 1220 RISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQP 1279

Query: 3241 AAPTPTPAPVPVPVP-LPAPAPAPHGEAR---ILTVTPSNQLQGLPLTPPVVVTHGVQIV 3296
             +   T +P     P L   +   +  +R     TV P +    +    P          
Sbjct: 1280 GSTHSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHSTTTSVHGEEPTTFHSRPAST 1339

Query: 3297 HSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQG------PPPEGEP 3350
            H++  LF E       T    A       PA++  GLP+   TA  G      P   G  
Sbjct: 1340 HTT--LFTEDSTTSGLTEESTA---FPGSPASTQTGLPATLTTADLGEESTTFPSSSGST 1394

Query: 3351 LQPPQPVQSTQPAQPAPPCP----PSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPA 3406
                 P +ST         P    PS       P S   P +S+++    T    P    
Sbjct: 1395 GTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATL 1454

Query: 3407 GPANRP----PEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTT 3462
             PA        E  +        T  T+FP   + S   DL     T  + +       +
Sbjct: 1455 SPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTS---DLSQEPTTSHSSQGSTEATLS 1511

Query: 3463 SGPSTPPGLVLPHTEFQPAP 3482
             G +T   L    T F  +P
Sbjct: 1512 PGSTTASSLGQQSTTFHSSP 1531



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 208/1188 (17%), Positives = 349/1188 (29%), Gaps = 156/1188 (13%)

Query: 1569 ANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKD 1628
            A+STT    E   +FHS                  P              T   +P +  
Sbjct: 3818 ASSTTSGHSEKSTIFHS----------SPDASGTTPSSAHSTTSGRGESTTSRISPGS-- 3865

Query: 1629 SELKT-PPSVGPPSVTVV--TLESAPSALEKTTGDKTVEAPLVTEEKTV---EPATVSEE 1682
            +E+ T P S   P ++    T  S+P +   T    ++ +  V EE T    +P +    
Sbjct: 3866 TEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASMTSLGVGEESTTSRSQPGSTHST 3925

Query: 1683 AKPASEPAPAPVEQLEQV-DLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGAS 1741
              PAS   P   E+   V    PG+    E  + P         ++P    ++P +   +
Sbjct: 3926 VSPASTTTPGLSEESTTVYSSSPGST---ETTVFPRSTTTSVRREEPTTFHSRPASTHTT 3982

Query: 1742 FSQAESNVDP----------EPDSTQPLSKPAQKSEEANEPKAEKPDATADA-------- 1783
                +S               P STQ        + +  E     P ++           
Sbjct: 3983 LFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEESTTFPSSSGSTGTKLSPAR 4042

Query: 1784 EPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRK 1843
               +    E+ P    P+S +    P          KS    T  ++   ++   P T  
Sbjct: 4043 STTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTFYTSPRSPDATL--SPATTT 4100

Query: 1844 SERIDREKLKRSNSPRGEAQKLLELKMEAEKITR--TASKNSAADLEHP-EPSLPLSRTR 1900
            S  +  E     + P                +++  T S +S    E    P    + + 
Sbjct: 4101 SSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTTSHSSQGSTEATLSPGSTTASSL 4160

Query: 1901 RRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRA 1960
             +   + +++ GD E      + +    V           +     TP       T    
Sbjct: 4161 GQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASS----TSTGL 4216

Query: 1961 DEEEENEAKEPAE---TLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEV 2017
             EE       P+    T  PP     P    T     P      + P    +    T   
Sbjct: 4217 QEESTTFQSWPSSSDTTPSPPSTTAVPVEVSTTYHSRPS-----STPTTHFSASSTT--- 4268

Query: 2018 GPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKR 2077
               +G  E S    ++    G+     R         P T+P+     +      S +  
Sbjct: 4269 ---LGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTA 4325

Query: 2078 GRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGV---------VAVSPEKSESPQ 2128
            G S  S       +S ++ D  +SP    +     ES               P  +  P 
Sbjct: 4326 GLSEKSTTFY---SSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSMHTTAFPSSTTMPG 4382

Query: 2129 -KEDGLSSQLKSDPVDPDKEPEKEDVSASGP-------SPEATQ--LAKQMELEQAVEHI 2178
              ++  +S       D    P     S+ GP       SP +T+  L         +   
Sbjct: 4383 VSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLLEA 4442

Query: 2179 AKLAEASASAAYKADAPEGLAPEDRDKPAHQA-----SETELAAAIGSIINDISGEPENF 2233
            +    +S  + +   +P G      +    Q+       T       S   ++S      
Sbjct: 4443 STPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGS 4502

Query: 2234 PAPPPYP-----------GESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESS 2282
            P+  P              E  T +     A A  PS     T    SG++E      SS
Sbjct: 4503 PSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTT----SGLVEESTTYHSS 4558

Query: 2283 RPPVNAPDPSAGPTDTKEARGNSSETSHS--------VPEAKGSKEVEVTLVRKDKGRQK 2334
              P +        ++T   RG  S TSHS         P    +   E T      G   
Sbjct: 4559 --PGSTQTMHFPESNTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTA 4616

Query: 2335 TTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAAN-------EGTTVQHPEAPQE---- 2383
            TT       T+ +      SH  +        PA +       E TT        E    
Sbjct: 4617 TTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTAL 4676

Query: 2384 ---------EKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPP 2434
                      ++S   HS+P  + T+  S   +T   S+E +    +P   +  P     
Sbjct: 4677 PGSTTTPGLSEKSTTFHSSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARS 4736

Query: 2435 PQPAPVDE------EPQARFRVH-------SIIESDPVTPPSDPSIPIPTLPSVTAAKLS 2481
                 V+E       P +   +H       S    +  T  S  +  I + PS T+A + 
Sbjct: 4737 TTSGLVEESTAYHSSPGSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVE 4796

Query: 2482 PPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDP 2541
             P +    P     T   E  T       +ST S + P     + +    +T  +I    
Sbjct: 4797 EPTSYHSSPGSIATTHFPESSTTSGRSE-ESTASHSSPDTNGITPLPAHFTTSGRIAEST 4855

Query: 2542 K-YVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASE 2600
              Y+S  S+ +T  +TA    +SA   +         S +  ++  +P    +S I    
Sbjct: 4856 TFYISPGSMETTLASTATTPGLSAKSTI------LYSSSRSPDQTLSPASMTSSSISGEP 4909

Query: 2601 VLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLT 2648
              + +  E       P  T+       S    +    T    +P ++T
Sbjct: 4910 TSLYSQAESTHTTAFPASTTTSGLSQESTTFHSKPGSTETTLSPGSIT 4957



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 9/91 (9%)

Query: 242  SRSPHSSQSRNQS--PQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSS 299
            SR+ HSS +   S  P   ++    PT   S  GS + +   DS  S++S  S+ S +S 
Sbjct: 1940 SRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSTATTHFPDS--STTSGRSEESTASH 1997

Query: 300  SSSDDS-----PARSVQSAAVPAPTSQLLSS 325
            SS D +     PARS  S  +   T+  +SS
Sbjct: 1998 SSQDATGTIVLPARSTTSVLLGESTTSPISS 2028



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 32/103 (31%), Positives = 48/103 (46%), Gaps = 12/103 (11%)

Query: 233  PERNYQHSR---SRSPHSSQSR--NQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSS 287
            PE N    R   S + HSS +   + +P   ++    PT   S  GS + +   DS  S+
Sbjct: 4568 PESNTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDS--ST 4625

Query: 288  SSTSSDSSDSSSSSSDDS-----PARSVQSAAVPAPTSQLLSS 325
            +S  S+ S +S SS D +     PARS  S  +   T+  +SS
Sbjct: 4626 TSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISS 4668



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 31/101 (30%), Positives = 45/101 (44%), Gaps = 12/101 (11%)

Query: 230 GRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSS 289
           GR  E    HS +    SS     +P   ++    PT   S  GS + +   DS  S++S
Sbjct: 852 GRGEESTTSHSSTTHTISS-----APSTTSALVEEPTSYHSSPGSTATTHFPDS--STTS 904

Query: 290 TSSDSSDSSSSSSDDS-----PARSVQSAAVPAPTSQLLSS 325
             S+ S +S SS D +     PARS  S  +   T+  +SS
Sbjct: 905 GRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISS 945



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 33/116 (28%), Positives = 49/116 (42%), Gaps = 18/116 (15%)

Query: 239  HSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSS 298
            HS  RSP ++ S   +     S+ S        + SRSR  S+ + +   ST++      
Sbjct: 970  HSSPRSPATTLSPASTTSSGVSEES--------TTSRSRPGSTHTTAFPDSTTTPGLSRH 1021

Query: 299  SSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDG 354
            S++S  SP  S  +  +PA T+    S E      S G         STDT+L  G
Sbjct: 1022 STTSHSSPG-STDTTLLPASTTTSGPSQESTTSHSSSG---------STDTALSPG 1067



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 31/101 (30%), Positives = 45/101 (44%), Gaps = 12/101 (11%)

Query: 230  GRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSS 289
            GR  E    HS +    SS     +P   ++    PT   S  GS + +   DS  S++S
Sbjct: 3492 GRGEESTTSHSSTTHTISS-----APSTTSALVEEPTSYHSSPGSTATTHFPDS--STTS 3544

Query: 290  TSSDSSDSSSSSSDDS-----PARSVQSAAVPAPTSQLLSS 325
              S+ S +S SS D +     PARS  S  +   T+  +SS
Sbjct: 3545 GRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISS 3585



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 33/116 (28%), Positives = 49/116 (42%), Gaps = 18/116 (15%)

Query: 239  HSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSS 298
            HS  RSP ++ S   +     S+ S        + S SR  S+ + +   ST++      
Sbjct: 3610 HSSPRSPATTLSPASTTSSGVSEES--------TTSHSRPGSTHTTAFPDSTTTPGLSRH 3661

Query: 299  SSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDG 354
            S++S  SP  S  +  +PA T+   SS E      S G         STDT+L  G
Sbjct: 3662 STTSHSSPG-STDTTLLPASTTTSGSSQESTTSHSSSG---------STDTALSPG 3707



 Score = 32.7 bits (73), Expect = 6.8
 Identities = 62/287 (21%), Positives = 88/287 (30%), Gaps = 39/287 (13%)

Query: 1546 LERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPK 1605
            L R EE +   S  +    T   A STT  + E    +HS       M   E        
Sbjct: 4518 LGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQTMHFPESNTTSGRG 4577

Query: 1606 EVEKQEDTENHPKTP---ESAPENKDSELKTPPSV-GPPSVTVVT-------------LE 1648
            E    E T +H  T     SAP    + ++ P S    P  T  T               
Sbjct: 4578 E----ESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEES 4633

Query: 1649 SAPSALEKTTGDKTVEAPLVTE----EKTVEP---ATVSEEAKPASEPAPAPVEQLEQVD 1701
            +A  + +  TG   + A   T     E T  P    ++   A P S   P   E+     
Sbjct: 4634 TASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTPGLSEKSTTFH 4693

Query: 1702 LPPGADPDKEAAMMPAGV---EEGSSGDQPPYLDAKPPTPGASFS----QAESNVDPEPD 1754
              P + P    +     +   EE ++    P   A  P+P  S +    +  +     P 
Sbjct: 4694 SSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSPG 4753

Query: 1755 STQ----PLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPES 1797
            STQ    P S  A    E +         T  + P         P S
Sbjct: 4754 STQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTS 4800


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 94.7 bits (234), Expect = 1e-18
 Identities = 217/1058 (20%), Positives = 338/1058 (31%), Gaps = 152/1058 (14%)

Query: 2024 KESSMEPKAAEEEAGSEQKRDRK-----DAGTDKNPPETAPVEVVEKKPAPEKNSKSKRG 2078
            K+ + +P   +E        D K      + T  N   T+P     K   P  +      
Sbjct: 76   KKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD 135

Query: 2079 RSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERE--------------------SGVVA 2118
             S+ + L V+K  +++  +   + +  +    E+                     S V+A
Sbjct: 136  TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 195

Query: 2119 VSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHI 2178
                K+E+  K   L++  +  P  P KEP     +   P+P   + A     E A    
Sbjct: 196  KPTPKAETTTKGPALTTPKEPTPTTP-KEPAS--TTPKEPTPTTIKSAPTTPKEPA---- 248

Query: 2179 AKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPP 2238
                  SA    K  AP          P   A  T    A  +  +  +   E  P  P 
Sbjct: 249  -PTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 307

Query: 2239 YPGESQTDLQP----PAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAG 2294
             P  + T  +P    P       P E    T E      +  A T   +P    P   A 
Sbjct: 308  KPAPT-TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAP 366

Query: 2295 PTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVES 2354
             T  + A   + E S + P+       +       +    TT+S     T  K  +P  +
Sbjct: 367  TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP---TTPKEPSPTTT 423

Query: 2355 HVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEK-PHSTPPQSCTSDLSKIPSTENSSQ 2413
              P     +  +P   +      P+ P      E  P +T   + T+     P+T   + 
Sbjct: 424  KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETA 483

Query: 2414 EISVEERTPTKASVPPDLPP--PPQPAPVDEEPQARFRVHSIIESDPVTP----PSDPSI 2467
              + ++ TPT    P  L P  P +PAP   E  A           P TP    P+ P  
Sbjct: 484  PTTPKKLTPT---TPEKLAPTTPEKPAPTTPEELA-----------PTTPEEPTPTTPEE 529

Query: 2468 PIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDV 2527
            P PT P   AA  +P   +   P +  PT   E      +  A +TP    P   K    
Sbjct: 530  PAPTTPKA-AAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP 588

Query: 2528 DTSSSTLRKILMDPKYVSATSVT------STSVTTAIAEPVSAAPCLHEAPPP------- 2574
             T      K L        TS T      +T   TA   P   AP   + P P       
Sbjct: 589  TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTA 648

Query: 2575 --------PVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMP 2626
                    P   KKP  ++ AP  T       S+       ++ AP    +      + P
Sbjct: 649  PTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKP 708

Query: 2627 VSIDLENSQKIT--LAKPA----PQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLK 2680
                 E     T  ++ P     P T+       T  ++    P      P +  V T K
Sbjct: 709  APTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTK 768

Query: 2681 SLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVG---TVNAAPGTVNAAASAVNATAS 2737
                TPA     +       T   ++ TTP   T     T   A  T     S + AT +
Sbjct: 769  ----TPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTT 824

Query: 2738 AVT-----------VTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFH 2786
             VT           +T    T  +  VT T  T+T    +  P    K +  A  +    
Sbjct: 825  QVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATT 884

Query: 2787 PGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQK-TEGPQRISAKISQIPPASAMDI 2845
            P        +P           +T +   +      K T  P+++++ + ++ P S +  
Sbjct: 885  P--------KPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAE 936

Query: 2846 EFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKAD 2905
               Q+ ++    P+S      P       AG A   T   L+                  
Sbjct: 937  AMLQTTTRPNQTPNSKLVEVNPK---SEDAGGAEGETPHMLL------------------ 975

Query: 2906 RPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVT 2965
            RP +  PE       TP       +V  QGI      + N ++   + +   K +    T
Sbjct: 976  RPHVFMPE------VTP-DMDYLPRVPNQGI------IINPMLSDETNICNGKPVDGLTT 1022

Query: 2966 LKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPS 3003
            L+  T V    +    L+P  PP+ P++  TEV  +PS
Sbjct: 1023 LRNGTLVAFRGHYFWMLSPFSPPS-PARRITEVWGIPS 1059



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 191/944 (20%), Positives = 297/944 (31%), Gaps = 144/944 (15%)

Query: 1603 KPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKT 1662
            K   VE +E T  + +T     E K +  K   S+   S   +   S   A      + T
Sbjct: 146  KETTVETKETTTTNKQTSTDGKE-KTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETT 204

Query: 1663 VEAPLVTEEKTVEPATVSEEAKPA-SEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEE 1721
             + P +T  K   P T  E A     EP P  ++        P     K A   P     
Sbjct: 205  TKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAP 264

Query: 1722 GSSGD-------QPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKA 1774
             ++ +       +P     K P P  + S   +  +P P  T P  KPA  +     PK 
Sbjct: 265  TTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP--TTP-KKPAPTT-----PK- 315

Query: 1775 EKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVS 1834
             +P  T   EP      E AP ++ PA    +   P A K   P       TP + A   
Sbjct: 316  -EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT------TPKEPA--- 365

Query: 1835 IVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSL 1894
                P T K       K     +P+  A               T +K++    + P P+ 
Sbjct: 366  ----PTTPKEPAPTTTKEPSPTTPKEPAP--------------TTTKSAPTTTKEPAPTT 407

Query: 1895 PLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPP 1954
              S        S   T      + P     ++P  T  +           PTTP+   P 
Sbjct: 408  TKSAPTTPKEPSPTTT------KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT 461

Query: 1955 KTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEAT 2014
             T++ A        KEPA T  P E   +P + K      P+        K   T PE  
Sbjct: 462  TTKKPA----PTTPKEPAPT-TPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 514

Query: 2015 TEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSK 2074
                P+     +  EP     +A +          T K P  T P     K+PAP    +
Sbjct: 515  APTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP-----KEPAPTTPKE 569

Query: 2075 SKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLS 2134
            +                      A  +P+G A    +  +     +P+K    +     +
Sbjct: 570  T----------------------APTTPKGTAPTTLKEPA---PTTPKKPAPKELAPTTT 604

Query: 2135 SQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADA 2194
             +  S   D       +  + + P   A    K+              +  A    K  A
Sbjct: 605  KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 664

Query: 2195 PEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQ 2254
            P+ LAP     P    S+                EP   P  P  P  +  +  PP    
Sbjct: 665  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA--PTTPKKPAPTTPETPPPT--- 719

Query: 2255 ALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPE 2314
                      T E  +     E  T    P  + P+ SA PT  K    +  E      +
Sbjct: 720  ----------TSEVSTPTTTKEPTTIHKSPDESTPELSAEPT-PKALENSPKEPGVPTTK 768

Query: 2315 AKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTT 2374
               + + E+T   KDK  ++  R+  +  T     AP         +   E+    E TT
Sbjct: 769  TPAATKPEMTTTAKDKTTERDLRTTPETTT----AAP---------KMTKETATTTEKTT 815

Query: 2375 VQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPP 2434
                 A   +  S     T P   T+       T   + +++  ++T T   +   +  P
Sbjct: 816  ESKITATTTQVTSTTTQDTTPFKITT-----LKTTTLAPKVTTTKKTITTTEI---MNKP 867

Query: 2435 PQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPI-----PTLPSVTAAKLSPP--VASG 2487
             + A    +P+ R          P  P   P  P       T+P V   K +P     + 
Sbjct: 868  EETA----KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTS 923

Query: 2488 GIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSS 2531
             +P  +P +++        E   Q+T  P   P++K  +V+  S
Sbjct: 924  TMPELNPTSRIA-------EAMLQTTTRPNQTPNSKLVEVNPKS 960



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 166/715 (23%), Positives = 244/715 (34%), Gaps = 96/715 (13%)

Query: 2820 SGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYAN 2879
            S ++T+  ++ SAK   + P S +  +       +   P   T  +P    P+ PA    
Sbjct: 172  SAKETQSIEKTSAK--DLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTP 229

Query: 2880 VATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTP 2939
                 T + +A T    P  ++ K+   + ++P P       P T        T+    P
Sbjct: 230  KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTK---EP 286

Query: 2940 PVLVHNQLVLTPS--IVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHP-PALPSK-LP 2995
                      TP     TT KK A P T K      +PA      TP  P P  P +  P
Sbjct: 287  APTTTKSAPTTPKEPAPTTPKKPA-PTTPK------EPA----PTTPKEPTPTTPKEPAP 335

Query: 2996 TEVNHVPSGPSIPADRTVSHLAAAKLDAHSP-RPSGPGPSSFPRASHPSSTASTALSTNA 3054
            T     P+ P  PA       A       +P  P  P P++    S P++    A +T  
Sbjct: 336  TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS-PTTPKEPAPTTTK 394

Query: 3055 TVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRP 3114
            +       P P    S            + T     S  +  E    TP  P+ T   +P
Sbjct: 395  SAPTTTKEPAPTTTKS------------APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKP 442

Query: 3115 EALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQ 3174
                +P  P +P     + P   +T +PAP      A   P E            TAP  
Sbjct: 443  ----APTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKE------------TAPTT 486

Query: 3175 SEVLVMQSEYRLHPY-------TVPRDVRIMVHPHVTAVSEQ------PRAADGVVKVPP 3221
             + L   +  +L P        T P ++        T  + +      P+AA       P
Sbjct: 487  PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 546

Query: 3222 ASKAPQQPG----KEAAKTPDAKAAPTPTPAPVPVPVPLPAPA----PAPHGEARILTVT 3273
            A   P++P     KE A T   + APT      P  +  PAP     PAP   A   T  
Sbjct: 547  APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKE 606

Query: 3274 PSNQL--QGLPLTP--PVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAAS 3329
            P++    +  P TP      T       +  E       G   T       T  + PA  
Sbjct: 607  PTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK 666

Query: 3330 SVGLPSRTK----TAAQGP----PPEGEPLQPPQPVQST--QPAQPAPPCPPSQLGQPGQ 3379
             +  P+ TK    T +  P    P E  P  P +P  +T  +PA   P  PP    +   
Sbjct: 667  ELA-PTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 725

Query: 3380 PPSSKMPQVSQEAKGTQTGVEQPRLPAGPA-----NRPPEPHTQVQRAQAETGPTSFPSP 3434
            P ++K P    ++    T    P L A P      N P EP     +  A T P    + 
Sbjct: 726  PTTTKEPTTIHKSPDEST----PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA 781

Query: 3435 VSVSMKPDLPVSLPTQT-APKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSP 3488
               + + DL  +  T T APK      TT+  +T   +    T+      QD++P
Sbjct: 782  KDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 836



 Score = 92.4 bits (228), Expect = 7e-18
 Identities = 195/913 (21%), Positives = 298/913 (32%), Gaps = 114/913 (12%)

Query: 1814 KDKKPNKSKRSKTP------------------VQAAAVSIVEKPVTRKSERIDREK---L 1852
            KD K N++K+  TP                  V     S  +      S +I   K    
Sbjct: 67   KDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINP 126

Query: 1853 KRSNSPRGEAQKLLELKMEAE-----KITRTASKNSAADLEHPEPS-------------- 1893
            + S  P  +  K   L +  E     K T T +K ++ D +    S              
Sbjct: 127  RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD 186

Query: 1894 -LPLSRTRRRNVRSVYATMGDHENRSPVKEPV----EQPRVTRKRLERELQEAAAVPTTP 1948
              P S+   +       T       +P KEP     ++P  T  + E       + PTTP
Sbjct: 187  LAPTSKVLAKPTPKAETTTKGPALTTP-KEPTPTTPKEPASTTPK-EPTPTTIKSAPTTP 244

Query: 1949 RRGRPPKTRRRADEEEE---NEAKEPAETL---KPPEGWRSPRSQKTAAGGGPQGKKGKN 2002
            +   P  T+      +E      KEPA T      P   + P    T +      +    
Sbjct: 245  KEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT 304

Query: 2003 EPKVDA-TRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPET--AP 2059
             PK  A T P+      P+     +  EP    +E      ++       K  P T   P
Sbjct: 305  TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEP 364

Query: 2060 VEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAV 2119
                 K+PAP    +      +       KSA     + A +   +A    +  S     
Sbjct: 365  APTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK 424

Query: 2120 SPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIA 2179
             P  + +  KE   ++  K  P  P KEP     +   P+P  T+       ++      
Sbjct: 425  EP--APTTPKEPAPTTPKKPAPTTP-KEP--APTTPKEPAPTTTKKPAPTTPKEPAPTTP 479

Query: 2180 KLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPY 2239
            K    +         PE LAP   +KPA    E ELA             P     P P 
Sbjct: 480  KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE-ELA-------------PTTPEEPTPT 525

Query: 2240 PGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTK 2299
              E      P A A    P E    T        +  A T    P    P  +A  T   
Sbjct: 526  TPEEPAPTTPKAAAPN-TPKEPAPTTP-------KEPAPTTPKEPAPTTPKETAPTTPKG 577

Query: 2300 EARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPES 2359
             A     E + + P+    KE+  T  ++      +T   +   T  K  AP     P  
Sbjct: 578  TAPTTLKEPAPTTPKKPAPKELAPTTTKE----PTSTTCDKPAPTTPKGTAPTTPKEPAP 633

Query: 2360 NQAQGESPAANEG---TTVQHPEAPQEEKQSEK---PHSTP-PQSCTSDLSKIPSTENSS 2412
               +  +P   +G   TT++ P     +K + K   P +T  P S TSD    P+T   +
Sbjct: 634  TTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD-KPAPTTPKET 692

Query: 2413 QEISVEERTPTKASVP-PDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPI-P 2470
               + +E  PT    P P  P  P P   +       +  + I   P    S P +   P
Sbjct: 693  APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP--DESTPELSAEP 750

Query: 2471 TLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTP--SPALPPDTKASDVD 2528
            T  ++  +   P V +   P  + P   T    +  E   ++TP  + A P  TK +   
Sbjct: 751  TPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATT 810

Query: 2529 TSSSTLRKILMDPKYVSATSVTSTS-------VTTAIAEPVSAAP---CLHEAPPPPVDS 2578
            T  +T  KI      V++T+   T+        TT +A  V+         E    P ++
Sbjct: 811  TEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEET 870

Query: 2579 KKPLEEKTAPPVTN---NSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQ 2635
             KP +  T    T        +A +   +  K K  P +    T+   R   S   E + 
Sbjct: 871  AKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNP 930

Query: 2636 KITLAKPAPQTLT 2648
               +A+   QT T
Sbjct: 931  TSRIAEAMLQTTT 943



 Score = 76.6 bits (187), Expect = 4e-13
 Identities = 113/519 (21%), Positives = 167/519 (32%), Gaps = 67/519 (12%)

Query: 2991 PSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTAL 3050
            P    T+ N V + P I   + ++           PRPS       P  S  S   S  +
Sbjct: 102  PDTSTTQHNKVSTSPKITTAKPIN-----------PRPS------LPPNSDTSKETSLTV 144

Query: 3051 STNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITY 3110
            +   TV         +  S+   E++         +  S   L+     +  PT P    
Sbjct: 145  NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT-PKAET 203

Query: 3111 SIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARAT 3170
            + +  AL +P+   +P     + P   +  +P P  + +  +   P+E      P    +
Sbjct: 204  TTKGPALTTPK---EPTPTTPKEPASTTPKEPTPTTIKSAPTT--PKEPA----PTTTKS 254

Query: 3171 APVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPG 3230
            AP   +     +     P T P++      P  T   E            P   AP  P 
Sbjct: 255  APTTPKEPAPTTTKEPAP-TTPKE------PAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 307

Query: 3231 KEAAKTPDAKAAPTP---TPAPVPVPVPL---PAPA----PAPHGEARILTVTPSNQLQG 3280
            K A  TP   A  TP   TP     P P    PAP     PAP    +    TP      
Sbjct: 308  KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 367

Query: 3281 LPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTA 3340
             P  P    T                +     T   PA  T    P  +    P+ TK+A
Sbjct: 368  TPKEPAPTTT----------------KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 411

Query: 3341 AQGPP-PEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGV 3399
               P  P     + P P    +PA   P  P     +   P + K P  +   K   T  
Sbjct: 412  PTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTP 471

Query: 3400 EQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSL--PTQTAPKQPL 3457
            ++P         P  P         +  PT+   P   + +   P +   PT T P++P 
Sbjct: 472  KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP- 530

Query: 3458 FVPTTSGPSTP--PGLVLPHTEFQPAPKQDSSPHLTSQR 3494
              PTT   + P  P    P T  +PAP     P  T+ +
Sbjct: 531  -APTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPK 568



 Score = 72.4 bits (176), Expect = 8e-12
 Identities = 123/587 (20%), Positives = 180/587 (30%), Gaps = 72/587 (12%)

Query: 1600 KDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTG 1659
            K+  P   +K   T      P +  E   +  K P    P      T +SAP+  ++   
Sbjct: 346  KEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP 405

Query: 1660 DKTVEAPLVTEE----KTVEPA-TVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAM 1714
              T  AP   +E     T EPA T  +E  P +   PAP    E     P  +P      
Sbjct: 406  TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP-KEPAPTTTK 464

Query: 1715 MPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKA 1774
             PA           P  +  P TP     +  +   PE  +     KPA  + E   P  
Sbjct: 465  KPAPTTPKEPAPTTP-KETAPTTP-----KKLTPTTPEKLAPTTPEKPAPTTPEELAPTT 518

Query: 1775 -EKPDATADAEPDANQKAEAAPES-QPPASEDLEVDPPVAAKDKKPNKSKRS--KTPVQA 1830
             E+P  T   EP       AAP + + PA    +   P   K+  P   K +   TP   
Sbjct: 519  PEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 578

Query: 1831 AAVSIVE--------------KPVTRKSERIDREKLKRSNSPRGEA---QKLLELKMEAE 1873
            A  ++ E               P T K             +P+G A    K        E
Sbjct: 579  APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 638

Query: 1874 KITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKR 1933
                T    +   L+ P P+ P     +         +     + P     ++P  T  +
Sbjct: 639  PAPTTPKGTAPTTLKEPAPTTPKKPAPKE--------LAPTTTKGPTSTTSDKPAPTTPK 690

Query: 1934 LERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGG 1993
                       PTTP+  +P  T         +E   P  T +P    +SP         
Sbjct: 691  ETAPTTPKEPAPTTPK--KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 748

Query: 1994 GPQGKKGKNEPK---VDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGT 2050
             P  K  +N PK   V  T+  A T+                 E    ++ K   +D  T
Sbjct: 749  EPTPKALENSPKEPGVPTTKTPAATK----------------PEMTTTAKDKTTERDLRT 792

Query: 2051 DKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVD-------KSASLKNVDAAVSPR 2103
                   AP    E     EK ++SK   +     +         K  +LK    A    
Sbjct: 793  TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 852

Query: 2104 GAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEK 2150
                     E   +   PE++  P+     S      P  P K P+K
Sbjct: 853  TTKKTITTTE---IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKK 896



 Score = 65.5 bits (158), Expect = 9e-10
 Identities = 204/1026 (19%), Positives = 311/1026 (30%), Gaps = 130/1026 (12%)

Query: 2521 DTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKK 2580
            D K +  DTS++   K+   PK           +TTA  +P++  P L    PP  D+ K
Sbjct: 96   DFKVTTPDTSTTQHNKVSTSPK-----------ITTA--KPINPRPSL----PPNSDTSK 138

Query: 2581 PLEEKTAPPVTNNSEIQASEVLVAAD------KEKVAPVIAPKITSVISRMPVSIDLENS 2634
                +T+  V   + ++  E            KEK     + K T  I +     DL  +
Sbjct: 139  ----ETSLTVNKETTVETKETTTTNKQTSTDGKEKTT---SAKETQSIEKTSAK-DLAPT 190

Query: 2635 QKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVST-PAGPVNVL 2693
             K+ LAKP P+  T                  AL  P + + TT K   ST P  P    
Sbjct: 191  SKV-LAKPTPKAETTTKGP-------------ALTTPKEPTPTTPKEPASTTPKEPT--- 233

Query: 2694 KGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGV 2753
              P  + + P    TTP      T  +AP T    A       +  T    A T      
Sbjct: 234  --PTTIKSAP----TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA 287

Query: 2754 TATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEG 2813
              TT +        AP+T  K                P     PA             E 
Sbjct: 288  PTTTKSAPTTPKEPAPTTPKKPA--------------PTTPKEPAPTTPKEPTPTTPKEP 333

Query: 2814 VVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQA 2873
                      T      +A     P         ++    +  +P   T  +P    P+ 
Sbjct: 334  APTTKEPAPTTPKEPAPTAPKKPAPTTP------KEPAPTTPKEPAPTTTKEPSPTTPKE 387

Query: 2874 PAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLT 2933
            PA         T   +A T    P  ++ K+   + ++P P       P T         
Sbjct: 388  PA--------PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTP 439

Query: 2934 QGINTPPVLVHNQLVLTPS--IVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALP 2991
            +     P         TP     TT KK A P T K E     P     T      P  P
Sbjct: 440  K--KPAPTTPKEPAPTTPKEPAPTTTKKPA-PTTPK-EPAPTTPKETAPTTPKKLTPTTP 495

Query: 2992 SKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPR-PSGPGPSSFPRASHPSSTASTAL 3050
             KL       P+ P  PA  T   LA    +  +P  P  P P++ P+A+ P++    A 
Sbjct: 496  EKL------APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTT-PKAAAPNTPKEPAP 548

Query: 3051 ST-NATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQG--EVRMNTPTLPS 3107
            +T           P P       P       P ++ +    +       E+   T   P+
Sbjct: 549  TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 608

Query: 3108 ITYSIRPEALHSPR--APLQPQQIEVRAPQRASTPQPAPAGVPALASQHP--PEEEVHYH 3163
             T   +P A  +P+  AP  P++     P+  +   P       L    P  P++     
Sbjct: 609  STTCDKP-APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKE 667

Query: 3164 LPVARATAPVQ--SEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPP 3221
            L       P    S+     +     P T                 E P      V  P 
Sbjct: 668  LAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPT 727

Query: 3222 ASKAPQQPGKEAAK-TPDAKAAPTP-----TPAPVPVPVPLPAPAPAPHGEARILTVTPS 3275
             +K P    K   + TP+  A PTP     +P    VP      A  P         T  
Sbjct: 728  TTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTE 787

Query: 3276 NQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPS 3335
              L+    T P   T   ++   +    ++     I         T TQ      +    
Sbjct: 788  RDLR----TTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 843

Query: 3336 RTKTAAQGPPPE---------GEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMP 3386
             T  A +    +          +P +  +P      ++   P P      P +P S+K P
Sbjct: 844  TTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKP 903

Query: 3387 QVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVS 3446
            +     +  +T     ++ +      P         Q  T P   P+   V + P    +
Sbjct: 904  KTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDA 963

Query: 3447 LPTQTAPKQPLFVPTTSGPSTPPGL-VLPHTEFQPA---PKQDSSPHLTSQRPVDMVQLL 3502
               +      L  P    P   P +  LP    Q     P      ++ + +PVD +  L
Sbjct: 964  GGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDETNICNGKPVDGLTTL 1023

Query: 3503 KKYPIV 3508
            +   +V
Sbjct: 1024 RNGTLV 1029



 Score = 52.4 bits (124), Expect = 8e-06
 Identities = 175/925 (18%), Positives = 287/925 (31%), Gaps = 76/925 (8%)

Query: 2382 QEEKQSEKPHSTPP--QSCTSDLS----KIPSTENSSQEISVEERTPTKASVPPDLPPPP 2435
            ++ +  +KP   PP      S L     K+ + + S+ + +    +P   +  P  P P 
Sbjct: 70   KKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPS 129

Query: 2436 QPAPVDEEPQARFRVH--SIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQS 2493
             P   D   +    V+  + +E+   T  ++           T+AK +  +        +
Sbjct: 130  LPPNSDTSKETSLTVNKETTVETKETTT-TNKQTSTDGKEKTTSAKETQSIEKTSAKDLA 188

Query: 2494 PPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTS 2553
            P +KV             + P+P     TK   + T          +P   +    T T+
Sbjct: 189  PTSKVL------------AKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTT 236

Query: 2554 VTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPV 2613
            + +A   P   AP   ++ P       P   K   P T       +    A    K AP 
Sbjct: 237  IKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPT 296

Query: 2614 IAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVN-ALKGPV 2672
               +      + P     +     T  +P P   T    A T        P   A   P 
Sbjct: 297  TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTP--TTPKEPAPTTKEPAPTTPKEPAPTAPK 354

Query: 2673 KGSVTTLKS-LVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASA 2731
            K + TT K    +TP  P        +  T      TT  +A   T   AP T  +A + 
Sbjct: 355  KPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTT 414

Query: 2732 VNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPST-KCKQRASANENSRFHPGSM 2790
                +   T      T      T             AP+T K     +  + +   P   
Sbjct: 415  PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 474

Query: 2791 PVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIP----PASAMDIE 2846
                 +     +   L   T E +   +        P+ ++    + P    P       
Sbjct: 475  APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTT 534

Query: 2847 FQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADR 2906
             + +   +  +P   T  +P    P+ PA        +T   TA T       +++K   
Sbjct: 535  PKAAAPNTPKEPAPTTPKEPAPTTPKEPA-------PTTPKETAPTTPKGTAPTTLKEPA 587

Query: 2907 PSL-EKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVT 2965
            P+  +KP P  L+ +T  T+  T     +   T P               T  K   P T
Sbjct: 588  PTTPKKPAPKELAPTT--TKEPTSTTCDKPAPTTP----------KGTAPTTPKEPAPTT 635

Query: 2966 LKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHS 3025
             K E     P     T      P  P K P      P+    P   T    A       +
Sbjct: 636  PK-EPAPTTPKGTAPTTLKEPAPTTPKK-PAPKELAPTTTKGPTSTTSDKPAPT-----T 688

Query: 3026 PRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIP-VPQFISSIHPEQSVIMPPHSI 3084
            P+ + P     P  + P   A T   T          P   +  ++IH       P  S 
Sbjct: 689  PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 748

Query: 3085 TQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAP 3144
              T      S  E  + T   P+ T   +PE   +  A  +  + ++R     +T  P  
Sbjct: 749  EPTPKALENSPKEPGVPTTKTPAAT---KPEM--TTTAKDKTTERDLRTTPETTTAAPKM 803

Query: 3145 AGVPALASQHPPEEEVHYHLPVARATAPVQS---EVLVMQSEYRLHPYTVPR----DVRI 3197
                A  ++   E ++        +T    +   ++  +++       T  +       I
Sbjct: 804  TKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEI 863

Query: 3198 MVHPHVTAVSEQPRAADGVVKVP---PASKAPQQP-GKEAAKTPDAKAAPTPTPAPVPVP 3253
            M  P  TA   + RA +     P     +KAP++P   +  KT      P  TP P  + 
Sbjct: 864  MNKPEETA-KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMT 922

Query: 3254 VPLPAPAPAPH-GEARILTVTPSNQ 3277
              +P   P     EA + T T  NQ
Sbjct: 923  STMPELNPTSRIAEAMLQTTTRPNQ 947


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 94.7 bits (234), Expect = 1e-18
 Identities = 217/1058 (20%), Positives = 338/1058 (31%), Gaps = 152/1058 (14%)

Query: 2024 KESSMEPKAAEEEAGSEQKRDRK-----DAGTDKNPPETAPVEVVEKKPAPEKNSKSKRG 2078
            K+ + +P   +E        D K      + T  N   T+P     K   P  +      
Sbjct: 117  KKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD 176

Query: 2079 RSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERE--------------------SGVVA 2118
             S+ + L V+K  +++  +   + +  +    E+                     S V+A
Sbjct: 177  TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 236

Query: 2119 VSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHI 2178
                K+E+  K   L++  +  P  P KEP     +   P+P   + A     E A    
Sbjct: 237  KPTPKAETTTKGPALTTPKEPTPTTP-KEPAS--TTPKEPTPTTIKSAPTTPKEPA---- 289

Query: 2179 AKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPP 2238
                  SA    K  AP          P   A  T    A  +  +  +   E  P  P 
Sbjct: 290  -PTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 348

Query: 2239 YPGESQTDLQP----PAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAG 2294
             P  + T  +P    P       P E    T E      +  A T   +P    P   A 
Sbjct: 349  KPAPT-TPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAP 407

Query: 2295 PTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVES 2354
             T  + A   + E S + P+       +       +    TT+S     T  K  +P  +
Sbjct: 408  TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP---TTPKEPSPTTT 464

Query: 2355 HVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEK-PHSTPPQSCTSDLSKIPSTENSSQ 2413
              P     +  +P   +      P+ P      E  P +T   + T+     P+T   + 
Sbjct: 465  KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETA 524

Query: 2414 EISVEERTPTKASVPPDLPP--PPQPAPVDEEPQARFRVHSIIESDPVTP----PSDPSI 2467
              + ++ TPT    P  L P  P +PAP   E  A           P TP    P+ P  
Sbjct: 525  PTTPKKLTPT---TPEKLAPTTPEKPAPTTPEELA-----------PTTPEEPTPTTPEE 570

Query: 2468 PIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDV 2527
            P PT P   AA  +P   +   P +  PT   E      +  A +TP    P   K    
Sbjct: 571  PAPTTPKA-AAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP 629

Query: 2528 DTSSSTLRKILMDPKYVSATSVT------STSVTTAIAEPVSAAPCLHEAPPP------- 2574
             T      K L        TS T      +T   TA   P   AP   + P P       
Sbjct: 630  TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTA 689

Query: 2575 --------PVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMP 2626
                    P   KKP  ++ AP  T       S+       ++ AP    +      + P
Sbjct: 690  PTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKP 749

Query: 2627 VSIDLENSQKIT--LAKPA----PQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLK 2680
                 E     T  ++ P     P T+       T  ++    P      P +  V T K
Sbjct: 750  APTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTK 809

Query: 2681 SLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVG---TVNAAPGTVNAAASAVNATAS 2737
                TPA     +       T   ++ TTP   T     T   A  T     S + AT +
Sbjct: 810  ----TPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTT 865

Query: 2738 AVT-----------VTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRFH 2786
             VT           +T    T  +  VT T  T+T    +  P    K +  A  +    
Sbjct: 866  QVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATT 925

Query: 2787 PGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQK-TEGPQRISAKISQIPPASAMDI 2845
            P        +P           +T +   +      K T  P+++++ + ++ P S +  
Sbjct: 926  P--------KPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAE 977

Query: 2846 EFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKAD 2905
               Q+ ++    P+S      P       AG A   T   L+                  
Sbjct: 978  AMLQTTTRPNQTPNSKLVEVNPK---SEDAGGAEGETPHMLL------------------ 1016

Query: 2906 RPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVT 2965
            RP +  PE       TP       +V  QGI      + N ++   + +   K +    T
Sbjct: 1017 RPHVFMPE------VTP-DMDYLPRVPNQGI------IINPMLSDETNICNGKPVDGLTT 1063

Query: 2966 LKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPS 3003
            L+  T V    +    L+P  PP+ P++  TEV  +PS
Sbjct: 1064 LRNGTLVAFRGHYFWMLSPFSPPS-PARRITEVWGIPS 1100



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 191/944 (20%), Positives = 297/944 (31%), Gaps = 144/944 (15%)

Query: 1603 KPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKT 1662
            K   VE +E T  + +T     E K +  K   S+   S   +   S   A      + T
Sbjct: 187  KETTVETKETTTTNKQTSTDGKE-KTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETT 245

Query: 1663 VEAPLVTEEKTVEPATVSEEAKPA-SEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEE 1721
             + P +T  K   P T  E A     EP P  ++        P     K A   P     
Sbjct: 246  TKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAP 305

Query: 1722 GSSGD-------QPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKA 1774
             ++ +       +P     K P P  + S   +  +P P  T P  KPA  +     PK 
Sbjct: 306  TTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP--TTP-KKPAPTT-----PK- 356

Query: 1775 EKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVS 1834
             +P  T   EP      E AP ++ PA    +   P A K   P       TP + A   
Sbjct: 357  -EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT------TPKEPA--- 406

Query: 1835 IVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSL 1894
                P T K       K     +P+  A               T +K++    + P P+ 
Sbjct: 407  ----PTTPKEPAPTTTKEPSPTTPKEPAP--------------TTTKSAPTTTKEPAPTT 448

Query: 1895 PLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPP 1954
              S        S   T      + P     ++P  T  +           PTTP+   P 
Sbjct: 449  TKSAPTTPKEPSPTTT------KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT 502

Query: 1955 KTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEAT 2014
             T++ A        KEPA T  P E   +P + K      P+        K   T PE  
Sbjct: 503  TTKKPA----PTTPKEPAPT-TPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 555

Query: 2015 TEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSK 2074
                P+     +  EP     +A +          T K P  T P     K+PAP    +
Sbjct: 556  APTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP-----KEPAPTTPKE 610

Query: 2075 SKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLS 2134
            +                      A  +P+G A    +  +     +P+K    +     +
Sbjct: 611  T----------------------APTTPKGTAPTTLKEPA---PTTPKKPAPKELAPTTT 645

Query: 2135 SQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADA 2194
             +  S   D       +  + + P   A    K+              +  A    K  A
Sbjct: 646  KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 705

Query: 2195 PEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQ 2254
            P+ LAP     P    S+                EP   P  P  P  +  +  PP    
Sbjct: 706  PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA--PTTPKKPAPTTPETPPPT--- 760

Query: 2255 ALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPE 2314
                      T E  +     E  T    P  + P+ SA PT  K    +  E      +
Sbjct: 761  ----------TSEVSTPTTTKEPTTIHKSPDESTPELSAEPT-PKALENSPKEPGVPTTK 809

Query: 2315 AKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTT 2374
               + + E+T   KDK  ++  R+  +  T     AP         +   E+    E TT
Sbjct: 810  TPAATKPEMTTTAKDKTTERDLRTTPETTT----AAP---------KMTKETATTTEKTT 856

Query: 2375 VQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPP 2434
                 A   +  S     T P   T+       T   + +++  ++T T   +   +  P
Sbjct: 857  ESKITATTTQVTSTTTQDTTPFKITT-----LKTTTLAPKVTTTKKTITTTEI---MNKP 908

Query: 2435 PQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPI-----PTLPSVTAAKLSPP--VASG 2487
             + A    +P+ R          P  P   P  P       T+P V   K +P     + 
Sbjct: 909  EETA----KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTS 964

Query: 2488 GIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSS 2531
             +P  +P +++        E   Q+T  P   P++K  +V+  S
Sbjct: 965  TMPELNPTSRIA-------EAMLQTTTRPNQTPNSKLVEVNPKS 1001



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 166/715 (23%), Positives = 244/715 (34%), Gaps = 96/715 (13%)

Query: 2820 SGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYAN 2879
            S ++T+  ++ SAK   + P S +  +       +   P   T  +P    P+ PA    
Sbjct: 213  SAKETQSIEKTSAK--DLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTP 270

Query: 2880 VATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTP 2939
                 T + +A T    P  ++ K+   + ++P P       P T        T+    P
Sbjct: 271  KEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTK---EP 327

Query: 2940 PVLVHNQLVLTPS--IVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHP-PALPSK-LP 2995
                      TP     TT KK A P T K      +PA      TP  P P  P +  P
Sbjct: 328  APTTTKSAPTTPKEPAPTTPKKPA-PTTPK------EPA----PTTPKEPTPTTPKEPAP 376

Query: 2996 TEVNHVPSGPSIPADRTVSHLAAAKLDAHSP-RPSGPGPSSFPRASHPSSTASTALSTNA 3054
            T     P+ P  PA       A       +P  P  P P++    S P++    A +T  
Sbjct: 377  TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS-PTTPKEPAPTTTK 435

Query: 3055 TVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRP 3114
            +       P P    S            + T     S  +  E    TP  P+ T   +P
Sbjct: 436  SAPTTTKEPAPTTTKS------------APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKP 483

Query: 3115 EALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQ 3174
                +P  P +P     + P   +T +PAP      A   P E            TAP  
Sbjct: 484  ----APTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKE------------TAPTT 527

Query: 3175 SEVLVMQSEYRLHPY-------TVPRDVRIMVHPHVTAVSEQ------PRAADGVVKVPP 3221
             + L   +  +L P        T P ++        T  + +      P+AA       P
Sbjct: 528  PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEP 587

Query: 3222 ASKAPQQPG----KEAAKTPDAKAAPTPTPAPVPVPVPLPAPA----PAPHGEARILTVT 3273
            A   P++P     KE A T   + APT      P  +  PAP     PAP   A   T  
Sbjct: 588  APTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKE 647

Query: 3274 PSNQL--QGLPLTP--PVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAAS 3329
            P++    +  P TP      T       +  E       G   T       T  + PA  
Sbjct: 648  PTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK 707

Query: 3330 SVGLPSRTK----TAAQGP----PPEGEPLQPPQPVQST--QPAQPAPPCPPSQLGQPGQ 3379
             +  P+ TK    T +  P    P E  P  P +P  +T  +PA   P  PP    +   
Sbjct: 708  ELA-PTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 766

Query: 3380 PPSSKMPQVSQEAKGTQTGVEQPRLPAGPA-----NRPPEPHTQVQRAQAETGPTSFPSP 3434
            P ++K P    ++    T    P L A P      N P EP     +  A T P    + 
Sbjct: 767  PTTTKEPTTIHKSPDEST----PELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA 822

Query: 3435 VSVSMKPDLPVSLPTQT-APKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSP 3488
               + + DL  +  T T APK      TT+  +T   +    T+      QD++P
Sbjct: 823  KDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 877



 Score = 92.4 bits (228), Expect = 7e-18
 Identities = 195/913 (21%), Positives = 298/913 (32%), Gaps = 114/913 (12%)

Query: 1814 KDKKPNKSKRSKTP------------------VQAAAVSIVEKPVTRKSERIDREK---L 1852
            KD K N++K+  TP                  V     S  +      S +I   K    
Sbjct: 108  KDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINP 167

Query: 1853 KRSNSPRGEAQKLLELKMEAE-----KITRTASKNSAADLEHPEPS-------------- 1893
            + S  P  +  K   L +  E     K T T +K ++ D +    S              
Sbjct: 168  RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD 227

Query: 1894 -LPLSRTRRRNVRSVYATMGDHENRSPVKEPV----EQPRVTRKRLERELQEAAAVPTTP 1948
              P S+   +       T       +P KEP     ++P  T  + E       + PTTP
Sbjct: 228  LAPTSKVLAKPTPKAETTTKGPALTTP-KEPTPTTPKEPASTTPK-EPTPTTIKSAPTTP 285

Query: 1949 RRGRPPKTRRRADEEEE---NEAKEPAETL---KPPEGWRSPRSQKTAAGGGPQGKKGKN 2002
            +   P  T+      +E      KEPA T      P   + P    T +      +    
Sbjct: 286  KEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT 345

Query: 2003 EPKVDA-TRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPET--AP 2059
             PK  A T P+      P+     +  EP    +E      ++       K  P T   P
Sbjct: 346  TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEP 405

Query: 2060 VEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAV 2119
                 K+PAP    +      +       KSA     + A +   +A    +  S     
Sbjct: 406  APTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTK 465

Query: 2120 SPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIA 2179
             P  + +  KE   ++  K  P  P KEP     +   P+P  T+       ++      
Sbjct: 466  EP--APTTPKEPAPTTPKKPAPTTP-KEP--APTTPKEPAPTTTKKPAPTTPKEPAPTTP 520

Query: 2180 KLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPY 2239
            K    +         PE LAP   +KPA    E ELA             P     P P 
Sbjct: 521  KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE-ELA-------------PTTPEEPTPT 566

Query: 2240 PGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTK 2299
              E      P A A    P E    T        +  A T    P    P  +A  T   
Sbjct: 567  TPEEPAPTTPKAAAPN-TPKEPAPTTP-------KEPAPTTPKEPAPTTPKETAPTTPKG 618

Query: 2300 EARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPES 2359
             A     E + + P+    KE+  T  ++      +T   +   T  K  AP     P  
Sbjct: 619  TAPTTLKEPAPTTPKKPAPKELAPTTTKE----PTSTTCDKPAPTTPKGTAPTTPKEPAP 674

Query: 2360 NQAQGESPAANEG---TTVQHPEAPQEEKQSEK---PHSTP-PQSCTSDLSKIPSTENSS 2412
               +  +P   +G   TT++ P     +K + K   P +T  P S TSD    P+T   +
Sbjct: 675  TTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD-KPAPTTPKET 733

Query: 2413 QEISVEERTPTKASVP-PDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPI-P 2470
               + +E  PT    P P  P  P P   +       +  + I   P    S P +   P
Sbjct: 734  APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP--DESTPELSAEP 791

Query: 2471 TLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTP--SPALPPDTKASDVD 2528
            T  ++  +   P V +   P  + P   T    +  E   ++TP  + A P  TK +   
Sbjct: 792  TPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATT 851

Query: 2529 TSSSTLRKILMDPKYVSATSVTSTS-------VTTAIAEPVSAAP---CLHEAPPPPVDS 2578
            T  +T  KI      V++T+   T+        TT +A  V+         E    P ++
Sbjct: 852  TEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEET 911

Query: 2579 KKPLEEKTAPPVTN---NSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQ 2635
             KP +  T    T        +A +   +  K K  P +    T+   R   S   E + 
Sbjct: 912  AKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNP 971

Query: 2636 KITLAKPAPQTLT 2648
               +A+   QT T
Sbjct: 972  TSRIAEAMLQTTT 984



 Score = 76.6 bits (187), Expect = 4e-13
 Identities = 113/519 (21%), Positives = 167/519 (32%), Gaps = 67/519 (12%)

Query: 2991 PSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTAL 3050
            P    T+ N V + P I   + ++           PRPS       P  S  S   S  +
Sbjct: 143  PDTSTTQHNKVSTSPKITTAKPIN-----------PRPS------LPPNSDTSKETSLTV 185

Query: 3051 STNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITY 3110
            +   TV         +  S+   E++         +  S   L+     +  PT P    
Sbjct: 186  NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPT-PKAET 244

Query: 3111 SIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARAT 3170
            + +  AL +P+   +P     + P   +  +P P  + +  +   P+E      P    +
Sbjct: 245  TTKGPALTTPK---EPTPTTPKEPASTTPKEPTPTTIKSAPTT--PKEPA----PTTTKS 295

Query: 3171 APVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPG 3230
            AP   +     +     P T P++      P  T   E            P   AP  P 
Sbjct: 296  APTTPKEPAPTTTKEPAP-TTPKE------PAPTTTKEPAPTTTKSAPTTPKEPAPTTPK 348

Query: 3231 KEAAKTPDAKAAPTP---TPAPVPVPVPL---PAPA----PAPHGEARILTVTPSNQLQG 3280
            K A  TP   A  TP   TP     P P    PAP     PAP    +    TP      
Sbjct: 349  KPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 408

Query: 3281 LPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTA 3340
             P  P    T                +     T   PA  T    P  +    P+ TK+A
Sbjct: 409  TPKEPAPTTT----------------KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 452

Query: 3341 AQGPP-PEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGV 3399
               P  P     + P P    +PA   P  P     +   P + K P  +   K   T  
Sbjct: 453  PTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTP 512

Query: 3400 EQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSL--PTQTAPKQPL 3457
            ++P         P  P         +  PT+   P   + +   P +   PT T P++P 
Sbjct: 513  KEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP- 571

Query: 3458 FVPTTSGPSTP--PGLVLPHTEFQPAPKQDSSPHLTSQR 3494
              PTT   + P  P    P T  +PAP     P  T+ +
Sbjct: 572  -APTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPK 609



 Score = 72.4 bits (176), Expect = 8e-12
 Identities = 123/587 (20%), Positives = 180/587 (30%), Gaps = 72/587 (12%)

Query: 1600 KDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTG 1659
            K+  P   +K   T      P +  E   +  K P    P      T +SAP+  ++   
Sbjct: 387  KEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP 446

Query: 1660 DKTVEAPLVTEE----KTVEPA-TVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAM 1714
              T  AP   +E     T EPA T  +E  P +   PAP    E     P  +P      
Sbjct: 447  TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP-KEPAPTTTK 505

Query: 1715 MPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKA 1774
             PA           P  +  P TP     +  +   PE  +     KPA  + E   P  
Sbjct: 506  KPAPTTPKEPAPTTP-KETAPTTP-----KKLTPTTPEKLAPTTPEKPAPTTPEELAPTT 559

Query: 1775 -EKPDATADAEPDANQKAEAAPES-QPPASEDLEVDPPVAAKDKKPNKSKRS--KTPVQA 1830
             E+P  T   EP       AAP + + PA    +   P   K+  P   K +   TP   
Sbjct: 560  PEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 619

Query: 1831 AAVSIVE--------------KPVTRKSERIDREKLKRSNSPRGEA---QKLLELKMEAE 1873
            A  ++ E               P T K             +P+G A    K        E
Sbjct: 620  APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 679

Query: 1874 KITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKR 1933
                T    +   L+ P P+ P     +         +     + P     ++P  T  +
Sbjct: 680  PAPTTPKGTAPTTLKEPAPTTPKKPAPKE--------LAPTTTKGPTSTTSDKPAPTTPK 731

Query: 1934 LERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGG 1993
                       PTTP+  +P  T         +E   P  T +P    +SP         
Sbjct: 732  ETAPTTPKEPAPTTPK--KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 789

Query: 1994 GPQGKKGKNEPK---VDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGT 2050
             P  K  +N PK   V  T+  A T+                 E    ++ K   +D  T
Sbjct: 790  EPTPKALENSPKEPGVPTTKTPAATK----------------PEMTTTAKDKTTERDLRT 833

Query: 2051 DKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVD-------KSASLKNVDAAVSPR 2103
                   AP    E     EK ++SK   +     +         K  +LK    A    
Sbjct: 834  TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 893

Query: 2104 GAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEK 2150
                     E   +   PE++  P+     S      P  P K P+K
Sbjct: 894  TTKKTITTTE---IMNKPEETAKPKDRATNSKATTPKPQKPTKAPKK 937



 Score = 65.5 bits (158), Expect = 9e-10
 Identities = 204/1026 (19%), Positives = 311/1026 (30%), Gaps = 130/1026 (12%)

Query: 2521 DTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKK 2580
            D K +  DTS++   K+   PK           +TTA  +P++  P L    PP  D+ K
Sbjct: 137  DFKVTTPDTSTTQHNKVSTSPK-----------ITTA--KPINPRPSL----PPNSDTSK 179

Query: 2581 PLEEKTAPPVTNNSEIQASEVLVAAD------KEKVAPVIAPKITSVISRMPVSIDLENS 2634
                +T+  V   + ++  E            KEK     + K T  I +     DL  +
Sbjct: 180  ----ETSLTVNKETTVETKETTTTNKQTSTDGKEKTT---SAKETQSIEKTSAK-DLAPT 231

Query: 2635 QKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVST-PAGPVNVL 2693
             K+ LAKP P+  T                  AL  P + + TT K   ST P  P    
Sbjct: 232  SKV-LAKPTPKAETTTKGP-------------ALTTPKEPTPTTPKEPASTTPKEPT--- 274

Query: 2694 KGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGV 2753
              P  + + P    TTP      T  +AP T    A       +  T    A T      
Sbjct: 275  --PTTIKSAP----TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPA 328

Query: 2754 TATTGTVTMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEG 2813
              TT +        AP+T  K                P     PA             E 
Sbjct: 329  PTTTKSAPTTPKEPAPTTPKKPA--------------PTTPKEPAPTTPKEPTPTTPKEP 374

Query: 2814 VVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQA 2873
                      T      +A     P         ++    +  +P   T  +P    P+ 
Sbjct: 375  APTTKEPAPTTPKEPAPTAPKKPAPTTP------KEPAPTTPKEPAPTTTKEPSPTTPKE 428

Query: 2874 PAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLT 2933
            PA         T   +A T    P  ++ K+   + ++P P       P T         
Sbjct: 429  PA--------PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTP 480

Query: 2934 QGINTPPVLVHNQLVLTPS--IVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALP 2991
            +     P         TP     TT KK A P T K E     P     T      P  P
Sbjct: 481  K--KPAPTTPKEPAPTTPKEPAPTTTKKPA-PTTPK-EPAPTTPKETAPTTPKKLTPTTP 536

Query: 2992 SKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPR-PSGPGPSSFPRASHPSSTASTAL 3050
             KL       P+ P  PA  T   LA    +  +P  P  P P++ P+A+ P++    A 
Sbjct: 537  EKL------APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTT-PKAAAPNTPKEPAP 589

Query: 3051 ST-NATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQG--EVRMNTPTLPS 3107
            +T           P P       P       P ++ +    +       E+   T   P+
Sbjct: 590  TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 649

Query: 3108 ITYSIRPEALHSPR--APLQPQQIEVRAPQRASTPQPAPAGVPALASQHP--PEEEVHYH 3163
             T   +P A  +P+  AP  P++     P+  +   P       L    P  P++     
Sbjct: 650  STTCDKP-APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKE 708

Query: 3164 LPVARATAPVQ--SEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPP 3221
            L       P    S+     +     P T                 E P      V  P 
Sbjct: 709  LAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPT 768

Query: 3222 ASKAPQQPGKEAAK-TPDAKAAPTP-----TPAPVPVPVPLPAPAPAPHGEARILTVTPS 3275
             +K P    K   + TP+  A PTP     +P    VP      A  P         T  
Sbjct: 769  TTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTE 828

Query: 3276 NQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPS 3335
              L+    T P   T   ++   +    ++     I         T TQ      +    
Sbjct: 829  RDLR----TTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLK 884

Query: 3336 RTKTAAQGPPPE---------GEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMP 3386
             T  A +    +          +P +  +P      ++   P P      P +P S+K P
Sbjct: 885  TTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKP 944

Query: 3387 QVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVS 3446
            +     +  +T     ++ +      P         Q  T P   P+   V + P    +
Sbjct: 945  KTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDA 1004

Query: 3447 LPTQTAPKQPLFVPTTSGPSTPPGL-VLPHTEFQPA---PKQDSSPHLTSQRPVDMVQLL 3502
               +      L  P    P   P +  LP    Q     P      ++ + +PVD +  L
Sbjct: 1005 GGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDETNICNGKPVDGLTTL 1064

Query: 3503 KKYPIV 3508
            +   +V
Sbjct: 1065 RNGTLV 1070



 Score = 52.4 bits (124), Expect = 8e-06
 Identities = 175/925 (18%), Positives = 287/925 (31%), Gaps = 76/925 (8%)

Query: 2382 QEEKQSEKPHSTPP--QSCTSDLS----KIPSTENSSQEISVEERTPTKASVPPDLPPPP 2435
            ++ +  +KP   PP      S L     K+ + + S+ + +    +P   +  P  P P 
Sbjct: 111  KKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPS 170

Query: 2436 QPAPVDEEPQARFRVH--SIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQS 2493
             P   D   +    V+  + +E+   T  ++           T+AK +  +        +
Sbjct: 171  LPPNSDTSKETSLTVNKETTVETKETTT-TNKQTSTDGKEKTTSAKETQSIEKTSAKDLA 229

Query: 2494 PPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTS 2553
            P +KV             + P+P     TK   + T          +P   +    T T+
Sbjct: 230  PTSKVL------------AKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTT 277

Query: 2554 VTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPV 2613
            + +A   P   AP   ++ P       P   K   P T       +    A    K AP 
Sbjct: 278  IKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPT 337

Query: 2614 IAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVN-ALKGPV 2672
               +      + P     +     T  +P P   T    A T        P   A   P 
Sbjct: 338  TPKEPAPTTPKKPAPTTPKEPAPTTPKEPTP--TTPKEPAPTTKEPAPTTPKEPAPTAPK 395

Query: 2673 KGSVTTLKS-LVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASA 2731
            K + TT K    +TP  P        +  T      TT  +A   T   AP T  +A + 
Sbjct: 396  KPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTT 455

Query: 2732 VNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPST-KCKQRASANENSRFHPGSM 2790
                +   T      T      T             AP+T K     +  + +   P   
Sbjct: 456  PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 515

Query: 2791 PVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIP----PASAMDIE 2846
                 +     +   L   T E +   +        P+ ++    + P    P       
Sbjct: 516  APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTT 575

Query: 2847 FQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADR 2906
             + +   +  +P   T  +P    P+ PA        +T   TA T       +++K   
Sbjct: 576  PKAAAPNTPKEPAPTTPKEPAPTTPKEPA-------PTTPKETAPTTPKGTAPTTLKEPA 628

Query: 2907 PSL-EKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVT 2965
            P+  +KP P  L+ +T  T+  T     +   T P               T  K   P T
Sbjct: 629  PTTPKKPAPKELAPTT--TKEPTSTTCDKPAPTTP----------KGTAPTTPKEPAPTT 676

Query: 2966 LKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHS 3025
             K E     P     T      P  P K P      P+    P   T    A       +
Sbjct: 677  PK-EPAPTTPKGTAPTTLKEPAPTTPKK-PAPKELAPTTTKGPTSTTSDKPAPT-----T 729

Query: 3026 PRPSGPGPSSFPRASHPSSTASTALSTNATVMLAAGIP-VPQFISSIHPEQSVIMPPHSI 3084
            P+ + P     P  + P   A T   T          P   +  ++IH       P  S 
Sbjct: 730  PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 789

Query: 3085 TQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAP 3144
              T      S  E  + T   P+ T   +PE   +  A  +  + ++R     +T  P  
Sbjct: 790  EPTPKALENSPKEPGVPTTKTPAAT---KPEM--TTTAKDKTTERDLRTTPETTTAAPKM 844

Query: 3145 AGVPALASQHPPEEEVHYHLPVARATAPVQS---EVLVMQSEYRLHPYTVPR----DVRI 3197
                A  ++   E ++        +T    +   ++  +++       T  +       I
Sbjct: 845  TKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEI 904

Query: 3198 MVHPHVTAVSEQPRAADGVVKVP---PASKAPQQP-GKEAAKTPDAKAAPTPTPAPVPVP 3253
            M  P  TA   + RA +     P     +KAP++P   +  KT      P  TP P  + 
Sbjct: 905  MNKPEETA-KPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMT 963

Query: 3254 VPLPAPAPAPH-GEARILTVTPSNQ 3277
              +P   P     EA + T T  NQ
Sbjct: 964  STMPELNPTSRIAEAMLQTTTRPNQ 988


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
            sapiens]
          Length = 699

 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 142/651 (21%), Positives = 238/651 (36%), Gaps = 72/651 (11%)

Query: 1496 KKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFE-----QDSKRLQHLERKE 1550
            KKK   +DSE        D  EEE+E Q   A +    +        + + +       E
Sbjct: 79   KKKASSSDSE--------DSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSE 130

Query: 1551 EDSDFISGRIYGKQ-TSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPK--EV 1607
            E SD        KQ   +G      + + P     S   +     + E  K+QKPK   V
Sbjct: 131  ESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPV 190

Query: 1608 EKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPL 1667
              +  T+  PK   +AP+  + +  +  S    S +    E   +A    T  KTV    
Sbjct: 191  TVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAA---ATPKKTVPKKQ 247

Query: 1668 VTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQ 1727
            V  +  V+ AT       +SE + +  E+ ++  +     P        A   + S G Q
Sbjct: 248  VVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQ 307

Query: 1728 PP--YLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEP 1785
            PP   ++ + P   +  S  ES+   E +   P      K+     P  +  ++++D+  
Sbjct: 308  PPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSD 367

Query: 1786 DANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSE 1845
              + + + AP      +++    P V  K      +   K PV        +K +TRK++
Sbjct: 368  SDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGG-----QKLLTRKAD 422

Query: 1846 RIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVR 1905
                     S+S   E+    E K +    T      + A L  P    P         +
Sbjct: 423  ---------SSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAP---------Q 464

Query: 1906 SVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAA--AVPTTPRRGRPPKTRRRADEE 1963
                +  D ++ S  +   E+ + ++  ++++ Q+ A  A P+ P   +  K        
Sbjct: 465  GSRDSSSDSDSSSSEE---EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSS 521

Query: 1964 EENEAKEPAETLKPPEGWRSPRSQKTAAGG-----GPQGKKGKNEPKVDATRPEATTEVG 2018
             ++ ++E  E LK   G  SPR Q   A G        GK  KN  + +  + +A   V 
Sbjct: 522  SDDSSEEEEEKLK---GKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVS 578

Query: 2019 PQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRG 2078
                +K+      A E E    +K            P T P     K+   EK + S   
Sbjct: 579  KSGSLKKRKQNEAAKEAETPQAKK-------IKLQTPNTFP-----KRKKGEKRASSPFR 626

Query: 2079 RSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQK 2129
            R R   + VD   +  + DA    RGAA   GER + V+  +  KS   +K
Sbjct: 627  RVREEEIEVDSRVADNSFDA---KRGAAGDWGERANQVLKFTKGKSFRHEK 674



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 131/651 (20%), Positives = 230/651 (35%), Gaps = 107/651 (16%)

Query: 1760 SKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPN 1819
            +K  ++  +AN P A+K          A +KA ++ +S+  + E+ EV  P A K   P 
Sbjct: 61   AKVPERKLQANGPVAKK----------AKKKASSS-DSEDSSEEEEEVQGPPAKKAAVP- 108

Query: 1820 KSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTA 1879
             +KR   P   AA    E   + +S   D E+    +  +   QK ++ + +A K     
Sbjct: 109  -AKRVGLPPGKAAAKASESSSSEESSDDDDEE----DQKKQPVQKGVKPQAKAAKAPPKK 163

Query: 1880 SKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQ 1939
            +K+S +D +      P  + ++  +  V       + ++P K     P++   +      
Sbjct: 164  AKSSDSDSDSSSEDEP-PKNQKPKITPVTVKA---QTKAPPKPARAAPKIANGKAASSSS 219

Query: 1940 EAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKK 1999
             +++  ++             D EEE  A  P +T+        P+ Q  A         
Sbjct: 220  SSSSSSSSD------------DSEEEKAAATPKKTV--------PKKQVVAKA------- 252

Query: 2000 GKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAP 2059
                P   AT P            K SS E  +++EE   ++    K       PP +AP
Sbjct: 253  ----PVKAATTPTR----------KSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAP 298

Query: 2060 VEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVD-----------AAVSPRGAAAQ 2108
                     P K +  K+    +S  + D+S S    +           A   P  A   
Sbjct: 299  PPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKA 358

Query: 2109 AGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQ--LA 2166
            A        + S E  E+P K  G +    + P    K P  +  +A        Q  L 
Sbjct: 359  AESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLT 418

Query: 2167 KQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDI 2226
            ++ +   + E  +   E           P+  A      PA QA +    ++  S  +  
Sbjct: 419  RKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSS 478

Query: 2227 SGEPENFPAPPPYPGESQTDLQPPAGAQALQPS-----EEGMETDEAVSGILETEAATES 2281
              E E          +S    +P   A    PS     ++G       S   ++    E 
Sbjct: 479  EEEEEK-------TSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE 531

Query: 2282 SRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTR--SR 2339
                  +P P A      +A G S+ T+ +   AK S+E E     K K     ++  S 
Sbjct: 532  KLKGKGSPRPQA-----PKANGTSALTAQNGKAAKNSEEEE---EEKKKAAVVVSKSGSL 583

Query: 2340 RKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKP 2390
            +KR  N+   A  E+  P++ + + ++P          P+  + EK++  P
Sbjct: 584  KKRKQNE---AAKEAETPQAKKIKLQTPNT-------FPKRKKGEKRASSP 624



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 106/466 (22%), Positives = 167/466 (35%), Gaps = 77/466 (16%)

Query: 2242 ESQTDLQ-PPAGAQALQPSEEGMETDEAVSGILETEAATESS---------RPPVNA--- 2288
            E + ++Q PPA   A+     G+   +A +   E+ ++ ESS         + PV     
Sbjct: 92   EEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVK 151

Query: 2289 PDPSAGPTDTKEARGNSSETSHSV----PEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNT 2344
            P   A     K+A+ + S++  S     P+ +  K   VT+  + K   K  R+  K   
Sbjct: 152  PQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIAN 211

Query: 2345 NKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSK 2404
             K   +   S    S+    E  AA        P+    +KQ       P ++ T+   K
Sbjct: 212  GKAASSSSSSSSSSSSDDSEEEKAAAT------PKKTVPKKQVVA--KAPVKAATTPTRK 263

Query: 2405 IPSTENSSQEISVEERTPTK------ASVPP-DLPPPPQPAPVDEEPQARFRVHSIIESD 2457
              S+E+SS +   E++ P K      +SVPP   PPP +        +A  +   +  S+
Sbjct: 264  SSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSE 323

Query: 2458 PVTPPSDPSI----PIPTLPSVTAAKLSPPVA------------SGGIPHQSPPTKVTEW 2501
              +  SD S       PT   V+ A   PP A            S        P+K    
Sbjct: 324  DSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGT 383

Query: 2502 ITRQEEPRAQSTPSPALPP-------------------DTKASDVDTSSSTLRKILMDPK 2542
                    A +T SPA+ P                   D+ +S+ ++SSS   K     K
Sbjct: 384  TKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEK----TK 439

Query: 2543 YVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVL 2602
             + AT+    +   A++ P   AP          DS    EE+     T+ S ++     
Sbjct: 440  KMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEK---TSKSAVKKKPQK 496

Query: 2603 VAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITL---AKPAPQ 2645
            VA       P  A K  +  S    S D    ++  L     P PQ
Sbjct: 497  VAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQ 542



 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 90/449 (20%), Positives = 169/449 (37%), Gaps = 45/449 (10%)

Query: 736  SPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKS--------RLERYTK 787
            +P    S +E   SD E        ++ G  SS+ PP      KS         +E+   
Sbjct: 259  TPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQP 318

Query: 788  NEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQS 847
             E ++          E E++   K  V K  T     K K    SS SS++D  +E +++
Sbjct: 319  VESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAK-KAAESSSDSSDSD-SSEDDEA 376

Query: 848  PEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDT 907
            P KP    K S   ++K  +      + P     +      K++        KA   +  
Sbjct: 377  PSKPAGTTKNS---SNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTR------KADSSSSE 427

Query: 908  VKSSALDQ---KLQVSQTEPAKSDLSKLESVRMKVPK-------EKGLSSHVEVVEKEGR 957
             +SS+ ++   K  V+ T+P  +  + L     + P+       +   SS  E  EK  +
Sbjct: 428  EESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSK 487

Query: 958  LKARKHLKPEQPADGVS---AVDLEKLEARKRRFADSNLKAEKQKPEVK-KSSPEMEDAR 1013
               +K  KP++ A G +       +K +A     + S+  +E+++ ++K K SP  +  +
Sbjct: 488  SAVKK--KPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPK 545

Query: 1014 VLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASIS 1073
                      + +     E E E K  +  ++  +S  +K  + N  A   +  +   I 
Sbjct: 546  ANGTSALTAQNGKAAKNSEEEEEEKK-KAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIK 604

Query: 1074 VGSGSRPSSDLQARLGELAGES----VENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDV 1129
            +     P++  + + GE    S    V  +E++    +       +     D G     V
Sbjct: 605  L---QTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQV 661

Query: 1130 RK--NYCSLRDETPERKSGQEKSHSVNTE 1156
             K     S R E  ++K G  +  S++ +
Sbjct: 662  LKFTKGKSFRHEKTKKKRGSYRGGSISVQ 690



 Score = 42.7 bits (99), Expect = 0.007
 Identities = 115/588 (19%), Positives = 200/588 (34%), Gaps = 94/588 (15%)

Query: 821  KQKRKGKVHSPSSQSSETDQENEREQSP----------------EKPRSCNKLSREKADK 864
            K   K    S S +SS+ D E ++++ P                +K +S +  S   ++ 
Sbjct: 118  KAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSED 177

Query: 865  EGIAKNRLELMPCVVLTRVKE--KEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQT 922
            E     + ++ P  V  + K   K  +        K  +   + +  SS+ D + + +  
Sbjct: 178  EPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAA 237

Query: 923  EPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLE 982
             P K+           VPK++ ++   +   K      RK    E   D  S  + E+ +
Sbjct: 238  TPKKT-----------VPKKQVVA---KAPVKAATTPTRKSSSSE---DSSSDEEEEQKK 280

Query: 983  ARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQPDVSSREVILLREG--EAERKPV 1040
              K +    +       P  KKS       + + K+QP  SS +     +   E E+KP 
Sbjct: 281  PMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPP 340

Query: 1041 RKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAG--ESVEN 1098
             K ++ + + K           P   ++ A  S  S    SS+      + AG  ++  N
Sbjct: 341  TKAVVSKATTK-----------PPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSN 389

Query: 1099 QEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEK 1158
            +   + K    KP     Q +   G ++   RK   S  +E       ++    V T + 
Sbjct: 390  KPAVTTKSPAVKPAAAPKQPVG--GGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKP 447

Query: 1159 IGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDV 1218
                        KQ  Q  R    + + + SE          E E ++    V K PQ V
Sbjct: 448  KATAKAALSLPAKQAPQGSRDSSSDSDSSSSE----------EEEEKTSKSAVKKKPQKV 497

Query: 1219 TDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSPSVRHGSFHEDEDPIGS 1278
               + PSK             K+ +   S+   S+DS               E+E+    
Sbjct: 498  AGGAAPSK---------PASAKKGKAESSNSSSSDDSS-------------EEEEEK--- 532

Query: 1279 PRLLSVKGSPKVD-EKVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDEL 1337
               L  KGSP+    K    S +T +      N  +    ++ A +   K   L    + 
Sbjct: 533  ---LKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQN 589

Query: 1338 NRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRS---VRDLEPGEVPSDS 1382
                      A +  +  PN+  KR    KR+    R +   E+  DS
Sbjct: 590  EAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDS 637



 Score = 38.5 bits (88), Expect = 0.12
 Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 16/123 (13%)

Query: 231 RRPERNYQHSRSRSPHSSQS---RNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSS 287
           + P +  + S S S  SS+    +NQ P+         T++P        + ++  I++ 
Sbjct: 158 KAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPP-----KPARAAPKIANG 212

Query: 288 SSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRST 347
            + SS SS SSSSSSDDS     ++AA P  T      + K +      +K    P R +
Sbjct: 213 KAASSSSSSSSSSSSDDS--EEEKAAATPKKT------VPKKQVVAKAPVKAATTPTRKS 264

Query: 348 DTS 350
            +S
Sbjct: 265 SSS 267



 Score = 37.7 bits (86), Expect = 0.21
 Identities = 22/90 (24%), Positives = 40/90 (44%)

Query: 226 REVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSIS 285
           + V  ++P  + + S   S  SS+   + P +     +     P+   + S S SSDS S
Sbjct: 311 KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDS 370

Query: 286 SSSSTSSDSSDSSSSSSDDSPARSVQSAAV 315
           S    +      ++ +S + PA + +S AV
Sbjct: 371 SEDDEAPSKPAGTTKNSSNKPAVTTKSPAV 400



 Score = 32.7 bits (73), Expect = 6.8
 Identities = 30/120 (25%), Positives = 49/120 (40%), Gaps = 8/120 (6%)

Query: 247 SSQSRNQSPQRLASQA--SRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDD 304
           S  +  + PQ++A  A  S+P  +  G    S SSSSD    SS    +      S    
Sbjct: 486 SKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSD---DSSEEEEEKLKGKGSPRPQ 542

Query: 305 SPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQ---NLPVRSTDTSLKDGLFHEFKK 361
           +P  +  SA          +S E++E +K   + V    +L  R  + + K+    + KK
Sbjct: 543 APKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKK 602


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 92.8 bits (229), Expect = 6e-18
 Identities = 268/1330 (20%), Positives = 478/1330 (35%), Gaps = 211/1330 (15%)

Query: 1663 VEAPLVTEEKTVEPATVSEEAKPASEPAPA------------PVEQLEQVDLPPGADPDK 1710
            V  P+V + K  + A   E  KPA++P P+             V ++  V+ PP  +  K
Sbjct: 525  VPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVE-SK 583

Query: 1711 EAAMM----PAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLS------ 1760
            E  M+    P   E   S  +      + P+P  +    +   D +P + +  +      
Sbjct: 584  EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETK 643

Query: 1761 -KPAQKSEEANEPK---AEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDK 1816
             KP  K EE  +PK   A+K D T   + +  +K E   E +    ++ + +P    K +
Sbjct: 644  VKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKE 703

Query: 1817 KPNKS-KRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKI 1875
             P K  K+     +   V   EK   ++ +++ ++  K+S++P  EA+K   LK +  K 
Sbjct: 704  TPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKD-AKKSSTPLSEAKKPAALKPKVPKK 762

Query: 1876 TRTASKNS-AADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKE--------PVEQ 1926
              +  K+S AA     +  + + +   +   +V A +G     + V          P ++
Sbjct: 763  EESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKE 822

Query: 1927 PRVTR------KRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEG 1980
                R      + L ++ +E  A      +   P+     DEE+  E        +P E 
Sbjct: 823  LEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKET-------EPVEA 875

Query: 1981 WRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSME--PKAAEEEAG 2038
            +   + ++   G      +G    + +    +   E+ P   V++  ++   K  +E AG
Sbjct: 876  YVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEP---VEKQGVDDIEKFEDEGAG 932

Query: 2039 SEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLK-NVD 2097
             E+  +  D        E A  E  E+   PE++ +     S +     +   S K   D
Sbjct: 933  FEESSETGDY------EEKAETEEAEE---PEEDGEEHVCVSASKHSPTEDEESAKAEAD 983

Query: 2098 AAV-SPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSAS 2156
            A +   R + A   +R    +  + EK E+ Q E+           + D+E + ED    
Sbjct: 984  AYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEE-----------EADEEDKAEDAREE 1032

Query: 2157 GPSPEATQLAKQMELEQAVEHIA-KLAEASASAAYKADAPEGLAPEDRDKPAHQASETEL 2215
               PE      +ME E  V  +  K AEA       A+   G       +   Q+   E 
Sbjct: 1033 EYEPE------KMEAEDYVMAVVDKAAEAGG-----AEEQYGFLTTPTKQLGAQSPGREP 1081

Query: 2216 AAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILET 2275
            A++I                    PG S+++    A A   +  E+  E   A SG  ++
Sbjct: 1082 ASSIHD---------------ETLPGGSESE----ATASDEENREDQPEEFTATSGYTQS 1122

Query: 2276 EAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKT 2335
                 S   P+   D  + P D      N+ ET     E     + E +L  ++  +   
Sbjct: 1123 TIEISSEPTPM---DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD 1179

Query: 2336 TRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPP 2395
                         V P+      S     +    N   +   P +  EE +  +      
Sbjct: 1180 -------------VTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDA 1226

Query: 2396 QSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIE 2455
                   S     ++S   +S E+ +P+K+   P L P P P+P+++ P     V+  + 
Sbjct: 1227 YCSEVKASTTLDIKDSISAVSSEKVSPSKS---PSLSPSP-PSPLEKTPLGERSVNFSLT 1282

Query: 2456 SDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEE--PRAQST 2513
             + +   ++  +  P  P VT   +    A       SP  K  E ++  +     A  T
Sbjct: 1283 PNEIKVSAEAEV-APVSPEVTQEVVEEHCA-------SPEDKTLEVVSPSQSVTGSAGHT 1334

Query: 2514 PSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPP 2573
            P    P D K+S + T      +++  P  V      S   + A  E   A+    + P 
Sbjct: 1335 PYYQSPTDEKSSHLPT------EVIEKPPAVP----VSFEFSDAKDENERASVSPMDEPV 1384

Query: 2574 PPVDSKKPLEEKTAP---PVTNNSEIQASEVLVAADK-----------EKVAPVIAPKIT 2619
            P  DS+ P+E+  +P   P    SE      L A DK           EK     +P   
Sbjct: 1385 P--DSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQV 1442

Query: 2620 SVISRM------------------PVSIDLENSQKI-TLAKPAPQTLTGLVSALTGLVNV 2660
            S +S M                  P+  D    +K   +   + Q    L     G V+ 
Sbjct: 1443 SPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSP 1502

Query: 2661 SLVPVN---ALKGPVKGSVT--TLKSLVSTPAGPVNVLKGPVNVLTGPVNVLTTPVNATV 2715
            + + V+   + K   K S++  T+    +TP     V +   + + G  +V T    A+V
Sbjct: 1503 TQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDE-GVAEDTYSHMEGVASVST----ASV 1557

Query: 2716 GTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQ 2775
             T +    T +  + +++A   +   T       S  V+      T     ++PS +   
Sbjct: 1558 ATSSFPEPTTDDVSPSLHAEVGSPHSTE---VDDSLSVSVVQTPTTFQETEMSPSKEECP 1614

Query: 2776 RASANENSRFHP----GSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRIS 2831
            R  +     F P       PV D R   +         + E  + + +S Q  + P  + 
Sbjct: 1615 RPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHP-TVG 1673

Query: 2832 AKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQ 2891
            A +  I      ++++    S S ++  S++   PP + P     Y      S L+  +Q
Sbjct: 1674 AGVLHITENGPTEVDY----SPSDMQDSSLSHKIPPMEEP----SYTQDNDLSELISVSQ 1725

Query: 2892 TYNASPVISS 2901
               ASP  SS
Sbjct: 1726 V-EASPSTSS 1734



 Score = 80.5 bits (197), Expect = 3e-14
 Identities = 380/1990 (19%), Positives = 687/1990 (34%), Gaps = 342/1990 (17%)

Query: 757  SRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEK---TDKERTFDPERVE-RERRLIRKE 812
            ++   R+ S  SL P   + L    + + +K E    T       P +VE +E+ +++K+
Sbjct: 533  TKLKQRADSRESLKPAA-KPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKD 591

Query: 813  KVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRL 872
            K  K +T     + +V S    S    +  E++ +  KP         KA KE   K   
Sbjct: 592  KPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKP---------KAAKEKTVKKE- 641

Query: 873  ELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKL 932
                    T+VK ++ K     P +++  K D   +K                K +  K 
Sbjct: 642  --------TKVKPEDKKEEKEKPKKEVAKKEDKTPIK----------------KEEKPKK 677

Query: 933  ESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGV-SAVDLEKLEARKRRFADS 991
            E V+ +V KE         ++KE + + +K +K E P   V   V  E+ +  K+   + 
Sbjct: 678  EEVKKEVKKE---------IKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEP 728

Query: 992  NLKAEKQKPEVKKSSPEMEDARVLSKKQPDVSSREVILLREGEAERKPVRK---EILKRE 1048
              + +K   + KKSS  + +A+  +  +P V  +E  + ++  A  KP  K   +++K+E
Sbjct: 729  KKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKE 788

Query: 1049 SKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAG--------ESVENQE 1100
             K  +               +A+  + +   P+ +L+A    ++         E ++ +E
Sbjct: 789  GKAAEAVAAAVGTGATTAAVMAAAGI-AAIGPAKELEAERSLMSSPEDLTKDFEELKAEE 847

Query: 1101 VQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIG 1160
            V   K I  KPQL+ ++  D++  +  +  + Y   ++    +   +     + T E  G
Sbjct: 848  VDVTKDI--KPQLELIE--DEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEG 903

Query: 1161 IDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFG-SPKKDVDEYERRSLVHEVGKPPQD-- 1217
                  +   +++E   ++   ++E  + E  G     +  +YE ++   E  +P +D  
Sbjct: 904  ----ECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGE 959

Query: 1218 -----------VTDDSPPSK--------KKRMDHVDFDICTKRERNYRSSRQISEDSERT 1258
                        T+D   +K        +KR      D   + + +    +  +E SE  
Sbjct: 960  EHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEE 1019

Query: 1259 GGSPSVRHGSFHEDEDP---------IGSPRLLSVKGSPKVDEKVLPYSNITVREESLKF 1309
                     +  E+ +P         +      +  G  +     L      +  +S   
Sbjct: 1020 ADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGR 1079

Query: 1310 NPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRS 1369
             P  S   E +   ++   S   + DE NR D   +  A      +  S I+  S     
Sbjct: 1080 EPASSIHDETLPGGSE---SEATASDEENREDQPEEFTA---TSGYTQSTIEISSEPTPM 1133

Query: 1370 VRDLEPGEVPSDSDEDGEHKSHSPRASAL--YESSRLS--------------FLLRDRED 1413
                 P +V SD   + E +S S     +  YESS  S              F    + D
Sbjct: 1134 DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTD 1193

Query: 1414 KLRERDERLS-------SSLERNKFYSFALDKTITPDTKA--LLERAKSLSSSREENWSF 1464
                +D   S       SS+E +KF   AL      + KA   L+   S+S+   E  S 
Sbjct: 1194 ATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVS- 1252

Query: 1465 LDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIR---TDSEGKMDDKKEDHKEEEQE 1521
                        +K      S P P+    + ++ +    T +E K+  + E      + 
Sbjct: 1253 -----------PSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEV 1301

Query: 1522 RQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANS--TTDSIQEP 1579
             QE+     +       + K L+ +   +  +       Y +  ++  +S   T+ I++P
Sbjct: 1302 TQEV-----VEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKP 1356

Query: 1580 VVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGP 1639
              +  S   E +  + + +     P + E   D+E       S  E   S L++PP +G 
Sbjct: 1357 PAVPVS--FEFSDAKDENERASVSPMD-EPVPDSE-------SPIEKVLSPLRSPPLIGS 1406

Query: 1640 PSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQ 1699
             S      ES  SA +K +G +  E+P   EEK+ +  +  ++  P SE     + Q +Q
Sbjct: 1407 ES----AYESFLSADDKASG-RGAESPF--EEKSGKQGS-PDQVSPVSEMTSTSLYQDKQ 1458

Query: 1700 VDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPG-ASFSQAE-SNVDPEPDSTQ 1757
                    P KE        ++  +    P L       G  S +Q + S      + T+
Sbjct: 1459 EGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTK 1518

Query: 1758 PLSKPAQKSEEANEPKAE--KPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKD 1815
                    S+++  P  E    D  +  E  A+    +   S  P     +V P + A+ 
Sbjct: 1519 MSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEV 1578

Query: 1816 KKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLK----RSNSPRGEAQKLLELKME 1871
              P+ ++       + +VS+V+ P T +   +   K +     S SP   + K  + +  
Sbjct: 1579 GSPHSTEVD----DSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTP 1634

Query: 1872 A-EKITRTASKNSAADLEHPEPSLPLSRTRR----------------RNVRSVYATMGDH 1914
              +  +  +S +     E PE SL +  +R+                     V  +  D 
Sbjct: 1635 VQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDM 1694

Query: 1915 ENRSPVKE--PVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPA 1972
            ++ S   +  P+E+P  T+     EL   + V  +P         + A   +E+   + A
Sbjct: 1695 QDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVA 1754

Query: 1973 ETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRP-EATTEVGPQIGVKESSMEPK 2031
                PP       S  +      +G+K   +  +    P E++    P      S+++ K
Sbjct: 1755 ----PPRDMSLYASLTSEKVQSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEK 1810

Query: 2032 AAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSA 2091
             A   + S                 + P++    +P   +   S    +    LA+++  
Sbjct: 1811 TATCHSSS-----------------SPPIDAASAEPYGFR--ASVLFDTMQHHLALNRDL 1851

Query: 2092 SLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKE 2151
            S   +              E++SG             K  G  S     P +  + P++E
Sbjct: 1852 STPGL--------------EKDSG------------GKTPGDFSYAYQKPEETTRSPDEE 1885

Query: 2152 DVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQAS 2211
            D                    + +E   K + + +  +Y+        PED D       
Sbjct: 1886 DYDYESYEKTTRTSDVGGYYYEKIERTTK-SPSDSGYSYETIGKTTKTPEDGDYSYEIIE 1944

Query: 2212 ETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQ---------------PPAGAQAL 2256
            +T      G    DIS   E   +PP   G S    +                  G   L
Sbjct: 1945 KTTRTPEEGGYSYDIS---EKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTL 2001

Query: 2257 QPSEEGMETDEAVSGILETEA-ATESSRPPVNAPDPSA-------GPTDTKEARGNSSET 2308
                   ET E ++   E+E  + E+S      PD S          T T +A   S ET
Sbjct: 2002 GDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYET 2061

Query: 2309 S------HSVPEAKGSKEVEVTLVRK-DKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQ 2361
            S           ++  ++V++ LV   +    KT  S    N N     P+E    E   
Sbjct: 2062 SDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPN-----PLEWFASEEPT 2116

Query: 2362 AQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDL-----SKIPSTENSSQEIS 2416
             + E P    G     P   Q+ +Q ++   TPP S +        S +P        I+
Sbjct: 2117 EESEKPLTQSGGAPPPPGGKQQGRQCDE---TPPTSVSESAPSQTDSDVPPETEECPSIT 2173

Query: 2417 VE---------ERTPTKASVPPDLPPPPQPAPV-DEEPQARFRVHSIIESDPV------- 2459
             +         E  PT  +V      PP PAPV D  P  R    S+++ + +       
Sbjct: 2174 ADANIDSEDESETIPTDKTVTYKHMDPP-PAPVQDRSPSPRHPDVSMVDPEALAIEQNLG 2232

Query: 2460 -TPPSDPSIPIPTLPSVTAAKLSPPVAS--------------GGIPHQSPPTKVTEWITR 2504
                 D      T    T  K S PV                 G+   S   KV+   + 
Sbjct: 2233 KALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESS--DKVSRVASP 2290

Query: 2505 QEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSA 2564
            +++   +    P   P+ KA+  +      +         +A +  S S  TA A P + 
Sbjct: 2291 KKKESVEKAAKPTTTPEVKAARGEEKDKETKN--------AANASASKSAKTATAGPGTT 2342

Query: 2565 APCLHEAPPP 2574
                  A PP
Sbjct: 2343 KTTKSSAVPP 2352



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 266/1452 (18%), Positives = 514/1452 (35%), Gaps = 171/1452 (11%)

Query: 1288 PKVDEKVLPYSNITVREESLKFNPYDSSRR--EQMADMAKIKLSVLNSEDELNRWDSQMK 1345
            P   E  LP S +T     + ++P + + +    +      + ++L   ++L   D   +
Sbjct: 454  PNGQEVDLPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ 513

Query: 1346 QDAGRFDVS--FPNSIIKRDSLRKR--SVRDLEPGEVPSDSDE-DGEHKSHSPRASAL-- 1398
              A + D++   P  ++K+  L++R  S   L+P   P  S     E K  +P  + +  
Sbjct: 514  PLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNH 573

Query: 1399 ------YESSRLSFLLRDR----EDKLRERDERLSSSLERNKFYSFALDKTITP-DTKAL 1447
                   ES     + +D+    E K    ++ + S  E +   +   +K  T    KA 
Sbjct: 574  VEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAA 633

Query: 1448 LERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGK 1507
             E+     +  +      + +         +DK  +    +P      K+ K     E K
Sbjct: 634  KEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEK 693

Query: 1508 MDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSE 1567
             + KKE  KE   +  +    +     + +++ +  + +++  +D             ++
Sbjct: 694  KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKD-------------AK 740

Query: 1568 GANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENK 1627
             +++     ++P  L   +  +     +K+     KPKE  K +  +   K  E+     
Sbjct: 741  KSSTPLSEAKKPAAL-KPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAV 799

Query: 1628 DSELKTPPSVGPPSVTVV----------TLESAPSALEKTTGDKTVEAPLVTEEKTVEPA 1677
             +   T   +    +  +          +L S+P  L K   +   E   VT++   +  
Sbjct: 800  GTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLE 859

Query: 1678 TVSEEAK-PASEPAPAPVEQLE-QVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLD--- 1732
             + +E K   +EP  A V Q E +V   P   PD+          EG     P  L+   
Sbjct: 860  LIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEG---EGECEQTPEELEPVE 916

Query: 1733 -------AKPPTPGASFSQAESNVD-PEPDSTQPLSKPAQKSEE-------ANEPKAEKP 1777
                    K    GA F ++    D  E   T+   +P +  EE        + P  ++ 
Sbjct: 917  KQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEE 976

Query: 1778 DATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVE 1837
             A A+A+    +K E+       A ED+         D+   K +  ++  +A      +
Sbjct: 977  SAKAEADAYIREKRESVASGDDRAEEDM---------DEAIEKGEAEQSEEEA---DEED 1024

Query: 1838 KPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEK--ITRTASKNSAADLEHPEPSLP 1895
            K    + E  + EK++  +       K  E     E+     T +K   A     EP+  
Sbjct: 1025 KAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASS 1084

Query: 1896 LSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPT------TPR 1949
            +            AT  D ENR   ++  E+   T    +  + E ++ PT      TPR
Sbjct: 1085 IHDETLPGGSESEATASDEENR---EDQPEEFTATSGYTQSTI-EISSEPTPMDEMSTPR 1140

Query: 1950 RGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQK----TAAGGGPQGKKGKNEPK 2005
                 +T    +EE E+ ++E     K      S    K    T   G  +G K      
Sbjct: 1141 DVMSDETN---NEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDG 1197

Query: 2006 VDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKR----DRKDAGTDKNPPETAPVE 2061
             D     +T  + P   ++E      A  +   SE K     D KD+ +  +  + +P +
Sbjct: 1198 KDYNASAST--ISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSK 1255

Query: 2062 VVEKKPAPEKN-SKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVS 2120
                 P+P     K+  G               ++V+ +++P      A   E+ V  VS
Sbjct: 1256 SPSLSPSPPSPLEKTPLGE--------------RSVNFSLTPNEIKVSA---EAEVAPVS 1298

Query: 2121 PEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAK 2180
            PE ++   +E   S + K+  V     P +    ++G +P       +       E I K
Sbjct: 1299 PEVTQEVVEEHCASPEDKTLEV---VSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEK 1355

Query: 2181 LAEASASAAYKADAPE-----GLAPEDRDKPAHQASETELAAAIGS--IINDISGEPENF 2233
                  S  + +DA +      ++P D   P  ++   ++ + + S  +I   S      
Sbjct: 1356 PPAVPVSFEF-SDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFL 1414

Query: 2234 PAPPPYPGE-SQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPS 2292
             A     G  +++  +  +G Q        +    + S   + +    +   P+      
Sbjct: 1415 SADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQ 1474

Query: 2293 AGPTDTKEARGNSSETSHSVPEAK--GSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVA 2350
               TD  EA   SS+ + ++ E K       ++ + +    ++ T  S  +   + K   
Sbjct: 1475 EKKTDDVEAM--SSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSAT 1532

Query: 2351 PVESHVPESNQAQGESPAANEGTTV---QHPE------APQEEKQSEKPHSTP-PQSCTS 2400
            PV+  V E   +  E  A+    +V     PE      +P    +   PHST    S + 
Sbjct: 1533 PVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSV 1592

Query: 2401 DLSKIPSTENSSQEISVEERTPTKASV-PPDLPPPPQPAPVDEEPQARFRVHSIIESDPV 2459
             + + P+T   ++    +E  P   S+ PPD  P    +    +     +    IE    
Sbjct: 1593 SVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQE 1652

Query: 2460 TPPSDPSIPIPTLPSVTAAKLSP--PVASGGIPH--QSPPTKVTEWITRQEEPRAQSTPS 2515
            +P    ++          ++ SP  P    G+ H  ++ PT+V    +  ++    S+ S
Sbjct: 1653 SPEQSLAMDF--------SRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQD----SSLS 1700

Query: 2516 PALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPP 2575
              +PP  + S   T  + L +++   +  ++ S +S    + IA P+        APP  
Sbjct: 1701 HKIPPMEEPS--YTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRD 1758

Query: 2576 VDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKI---TSVISRMPVSIDLE 2632
            +     L  +    +        S++     +E  +P+ +P     TS +     +    
Sbjct: 1759 MSLYASLTSEKVQSLEGEKLSPKSDISPLTPRES-SPLYSPTFSDSTSAVKEKTATCHSS 1817

Query: 2633 NSQKITLAKPAP 2644
            +S  I  A   P
Sbjct: 1818 SSPPIDAASAEP 1829



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 344/1911 (18%), Positives = 672/1911 (35%), Gaps = 360/1911 (18%)

Query: 693  REYSYRQRERERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGASPSQAERLPSDSE 752
            +E   +  +++ E+E+ + +  +  ++ PI++ + P              + E +  + +
Sbjct: 640  KETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKP--------------KKEEVKKEVK 685

Query: 753  RRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKE 812
            + +                   +K +K       K  K + ++   P+ V++E +   K+
Sbjct: 686  KEI-------------------KKEEK-------KEPKKEVKKETPPKEVKKEVKKEEKK 719

Query: 813  KVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRL 872
            +V+K++ + +K   K+   + +SS T     ++ +  KP+   K   E   K+ +A  + 
Sbjct: 720  EVKKEEKEPKKEIKKLPKDAKKSS-TPLSEAKKPAALKPKVPKK--EESVKKDSVAAGKP 776

Query: 873  ELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSAL---------------DQKL 917
            +    +   +V +KEGK       E + A +      ++ +                ++ 
Sbjct: 777  KEKGKI---KVIKKEGKA-----AEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERS 828

Query: 918  QVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLK------------ 965
             +S  E    D  +L++  + V K+  +   +E++E E +LK  + ++            
Sbjct: 829  LMSSPEDLTKDFEELKAEEVDVTKD--IKPQLELIEDEEKLKETEPVEAYVIQKEREVTK 886

Query: 966  --PEQPADGVSAVD--------LEKLEARKRRFADSNLKAEKQKPEVKKSSPE---MEDA 1012
               E P +G++  +         E+LE  +++  D   K E +    ++SS      E A
Sbjct: 887  GPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKA 946

Query: 1013 RVLSKKQPDVSSREVILLREGEAERKPVR-KEILKRESKKIKLDRLNTVASPKD-CQELA 1070
                 ++P+    E + +    ++  P   +E  K E+     ++  +VAS  D  +E  
Sbjct: 947  ETEEAEEPEEDGEEHVCV--SASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDM 1004

Query: 1071 SISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQ-LQVLDDQGPEREDV 1129
              ++  G    S+      E A E  + ++ + ++  P K + +  +  + D+  E    
Sbjct: 1005 DEAIEKGEAEQSE------EEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGA 1058

Query: 1130 RKNYCSLRDETPE---RKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEI 1186
             + Y  L   T +   +  G+E + S++ E   G     ++S     ++  R+ Q E   
Sbjct: 1059 EEQYGFLTTPTKQLGAQSPGREPASSIHDETLPG----GSESEATASDEENREDQPEEFT 1114

Query: 1187 AKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERN-Y 1245
            A S   G  +  ++     + + E+   P+DV  D   +++      +F   TK E + Y
Sbjct: 1115 ATS---GYTQSTIEISSEPTPMDEM-STPRDVMSDETNNEETESPSQEFVNITKYESSLY 1170

Query: 1246 RSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVREE 1305
                    D     G          + +D   S   +S   S + D+    +S   +R+ 
Sbjct: 1171 SQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDK----FSRSALRD- 1225

Query: 1306 SLKFNPYDSSRREQMADMAKIKLS-VLNSEDELNRWDSQMKQDAGRFDVS-FPNSIIKRD 1363
                           A  +++K S  L+ +D ++   S+    +    +S  P S +++ 
Sbjct: 1226 ---------------AYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKT 1270

Query: 1364 SLRKRSVR-DLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERL 1422
             L +RSV   L P E+   ++ +    S       + E         D+  ++    + +
Sbjct: 1271 PLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASP---EDKTLEVVSPSQSV 1327

Query: 1423 SSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEK 1482
            + S     +Y    D+  +     ++E+  ++  S E           F++ ++  ++  
Sbjct: 1328 TGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE-----------FSDAKDENERAS 1376

Query: 1483 VDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKR 1542
            V     P+P      +K+ +          E   E      +  + R   S  FE+ S +
Sbjct: 1377 VSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESP-FEEKSGK 1435

Query: 1543 LQHLERKEEDSDFISGRIY-----GKQT-------SEGANSTTDSIQ----EPVVLFHSR 1586
                ++    S+  S  +Y     GK T         G    TD ++    +P +    R
Sbjct: 1436 QGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDER 1495

Query: 1587 -----------------FMELTRMQQKE---KEKDQKPKEVEKQEDTENHPKTPESA--- 1623
                             F E T+M   E    +K   P +    EDT +H +   S    
Sbjct: 1496 KLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTA 1555

Query: 1624 ---------PENKDSELKTPPSVGPPSVTVVTLESAPSALE-KTTGDKTVEAPLVTEEKT 1673
                     P   D        VG P  T V    + S ++  TT  +T  +P  ++E+ 
Sbjct: 1556 SVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSP--SKEEC 1613

Query: 1674 VEPATVS-EEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLD 1732
              P ++S  +  P +  +  PV+           +  +E+      ++   S   P +  
Sbjct: 1614 PRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMD--FSRQSPDH-- 1669

Query: 1733 AKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAE 1792
               PT GA       N   E D +    + +  S +   P  E+P  T D     N  +E
Sbjct: 1670 ---PTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKI--PPMEEPSYTQD-----NDLSE 1719

Query: 1793 AAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKP---------VTRK 1843
                SQ  AS       P  +    P+   +  +P+Q   +S V  P          + K
Sbjct: 1720 LISVSQVEAS-------PSTSSAHTPS---QIASPLQEDTLSDVAPPRDMSLYASLTSEK 1769

Query: 1844 SERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLE-----HPEPSLPLSR 1898
             + ++ EKL    SP+ +   L   +  +   + T S +++A  E     H   S P+  
Sbjct: 1770 VQSLEGEKL----SPKSDISPLTP-RESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDA 1824

Query: 1899 TRRR----NVRSVYATMGDH--ENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGR 1952
                        ++ TM  H   NR           ++   LE++         +    +
Sbjct: 1825 ASAEPYGFRASVLFDTMQHHLALNRD----------LSTPGLEKDSGGKTPGDFSYAYQK 1874

Query: 1953 PPKTRRRADEEE-ENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRP 2011
            P +T R  DEE+ + E+ E         G+   + ++T       G   +   K   T  
Sbjct: 1875 PEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPE 1934

Query: 2012 ---------EATT----EVGPQIGVKESSMEPKAAEEEAGSEQKRDRK------------ 2046
                     E TT    E G    + E +  P      +  + +R R+            
Sbjct: 1935 DGDYSYEIIEKTTRTPEEGGYSYDISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDS 1994

Query: 2047 -DAGTDKNPPETAPVEVVEKKPA-PEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRG 2104
             D G     P  +  E  EK  + PE    S    ++ +R   D S         ++   
Sbjct: 1995 EDGGHTLGDPSYS-YETTEKITSFPESEGYSYETSTKTTR-TPDTSTYCYETAEKITRTP 2052

Query: 2105 AAAQAGERESGVVAVSPEKSESPQKED----------------GLS-SQLKSDPV----- 2142
             A+      S +   + +KS S  ++D                 LS S +  +P+     
Sbjct: 2053 QASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFAS 2112

Query: 2143 -DPDKEPEKEDVSASG--PSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLA 2199
             +P +E EK    + G  P P   Q  +Q +         +    S S +  +     + 
Sbjct: 2113 EEPTEESEKPLTQSGGAPPPPGGKQQGRQCD---------ETPPTSVSESAPSQTDSDVP 2163

Query: 2200 PEDRDKPAHQASETELAAAIGSIINDISGEPENFPA----------PPPYPGESQTDLQP 2249
            PE  + P+  A              D   E E  P           PPP P + ++    
Sbjct: 2164 PETEECPSITADAN----------IDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPR 2213

Query: 2250 PAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETS 2309
                  + P    +E +   +   + +  T++ +P       S      K++ G S   +
Sbjct: 2214 HPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSS----PVKKSDGKSKPLA 2269

Query: 2310 HSVPEAKGSKEV--EVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESP 2367
             S P+  G KE   +V+ V   K ++   ++ +   T +   A  E    E+  A   S 
Sbjct: 2270 AS-PKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASA 2328

Query: 2368 AANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVE 2418
            + +  T    P   +  K S  P   P      DL  IP+  N S+ + VE
Sbjct: 2329 SKSAKTATAGPGTTKTTKSSAVPPGLP---VYLDLCYIPNHSN-SKNVDVE 2375



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 352/1911 (18%), Positives = 645/1911 (33%), Gaps = 330/1911 (17%)

Query: 929  LSKLESVRMKVPKEKGLSSHVEV-VEKEGRLK----ARKHLKP------------EQPAD 971
            L  L+ ++  +  +K L+  V   V K+ +LK    +R+ LKP            E   +
Sbjct: 505  LKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEE 564

Query: 972  GVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQPDVSSREVILLR 1031
                  +  +E   +  +   +  +K KP   ++ P + +  V SK++P     EV   +
Sbjct: 565  TPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQ 624

Query: 1032 EGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGEL 1091
              + + K  +++ +K+E+K            P+D +E          +P  ++  +    
Sbjct: 625  ATDVKPKAAKEKTVKKETK----------VKPEDKKE-------EKEKPKKEVAKK---- 663

Query: 1092 AGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSH 1151
                 E++    K+  P K ++K+    + +  E+++ +K    ++ ETP ++  +E   
Sbjct: 664  -----EDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKK---EVKKETPPKEVKKE--- 712

Query: 1152 SVNTEEKIGIDIDHTQSYR--KQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVH 1209
             V  EEK  +  +  +  +  K++ +  +K    +  AK      PK    E   +    
Sbjct: 713  -VKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV 771

Query: 1210 EVGKPPQDVTDDSPPSKKKRMDHVDFDICT----------------------KRERNYRS 1247
              GKP +         + K  + V   + T                      + ER+  S
Sbjct: 772  AAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMS 831

Query: 1248 S-RQISEDSERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVREES 1306
            S   +++D E               D      P+L  ++   K+ E     + +  +E  
Sbjct: 832  SPEDLTKDFEELKAE--------EVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKERE 883

Query: 1307 LKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFD---VSFPNSIIKRD 1363
            +   P +S   ++     + +     + +EL   + Q   D  +F+     F  S    D
Sbjct: 884  VTKGPAESP--DEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGD 941

Query: 1364 SLRKRSVRDLEPGEVPSDSDEDGEH------KSHSPRASALYESSRLSFLLRDREDKLRE 1417
               K    + E      + +EDGE         HSP        +     +R++ + +  
Sbjct: 942  YEEKAETEEAE------EPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVAS 995

Query: 1418 RDERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENW------------SFL 1465
             D+R    ++       A++K     ++   +       +REE +            + +
Sbjct: 996  GDDRAEEDMDE------AIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVV 1049

Query: 1466 DWDSRFA------NFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEE 1519
            D  +          F     K+    +P   P+  +  + +   SE +     E+++E++
Sbjct: 1050 DKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQ 1109

Query: 1520 QERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEP 1579
             E  E  A+     S  E  S+    ++      D +S     ++T   +    +  +  
Sbjct: 1110 PE--EFTATSGYTQSTIEISSEPTP-MDEMSTPRDVMSDETNNEETESPSQEFVNITKYE 1166

Query: 1580 VVLFHSRFME------LTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKD----- 1628
              L+   + +      L    +  K      K+      T + P + E    ++      
Sbjct: 1167 SSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDA 1226

Query: 1629 --SELKTPPSVG-PPSVTVVTLE------------SAPSALEKT-TGDKTVEAPLVTEEK 1672
              SE+K   ++    S++ V+ E            S PS LEKT  G+++V   L   E 
Sbjct: 1227 YCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNE- 1285

Query: 1673 TVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEA--AMMPAGVEEGSSGDQPPY 1730
                  VS EA    E AP   E  ++V     A P+ +    + P+    GS+G  P Y
Sbjct: 1286 ----IKVSAEA----EVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYY 1337

Query: 1731 --------------LDAKPPTPGASFSQAESN-----------VDPEPDSTQPLSK---- 1761
                          +  KPP    SF  +++             +P PDS  P+ K    
Sbjct: 1338 QSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSP 1397

Query: 1762 ----PAQKSEEANEP--KAEKPDATADAEPDANQKA--EAAPESQPPASEDLEVDPPVAA 1813
                P   SE A E    A+   +   AE    +K+  + +P+   P S   E+      
Sbjct: 1398 LRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVS---EMTSTSLY 1454

Query: 1814 KDKKPNKSKRSKTPV-----QAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLEL 1868
            +DK+  KS     P+     Q      VE   ++ +  +D  KL   +  + +  +    
Sbjct: 1455 QDKQEGKS-TDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSF 1513

Query: 1869 KMEAEKITR--TASKNSAADLE---------HPEPSLPLSRTRRRNVRSVYATMGD---- 1913
            K + +      T S  SA  ++         H E    +S            T  D    
Sbjct: 1514 KEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPS 1573

Query: 1914 --HENRSPVKEPVEQP-RVTRKRLERELQEAAAVPTTPRRGRP---------PKTRRRAD 1961
               E  SP    V+    V+  +     QE    P+     RP         PKT +   
Sbjct: 1574 LHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRT 1633

Query: 1962 EEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQI 2021
              +++ +++ + +++   G  SP             ++  + P V A     T     ++
Sbjct: 1634 PVQDHRSEQSSMSIE--FGQESPEQSLAM----DFSRQSPDHPTVGAGVLHITENGPTEV 1687

Query: 2022 GVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSR 2081
                S M+  +   +       +      D +  E   V  VE  P+        +  S 
Sbjct: 1688 DYSPSDMQDSSLSHKI---PPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASP 1744

Query: 2082 NSRLAVDKSASLKNVDAAVSPRGAAAQA--GERESGVVAVSPEKSESPQKEDGLSSQLKS 2139
                 +   A  +++    S      Q+  GE+ S    +SP    +P++   L S   S
Sbjct: 1745 LQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISP---LTPRESSPLYSPTFS 1801

Query: 2140 DPVDPDKEPEKEDVSASGP-----SPEATQLAKQMELEQAVEHIAKLAEASA-------- 2186
            D     KE      S+S P     S E       +  +    H+A   + S         
Sbjct: 1802 DSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSG 1861

Query: 2187 -------SAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPY 2239
                   S AY+       +P++ D       +T   + +G    +        P+   Y
Sbjct: 1862 GKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGY 1921

Query: 2240 PGES--QTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPT- 2296
              E+  +T   P  G  + +  E+   T E   G    + + +++ PP      S   T 
Sbjct: 1922 SYETIGKTTKTPEDGDYSYEIIEKTTRTPE--EGGYSYDISEKTTSPP-EVSGYSYEKTE 1978

Query: 2297 -------DTKEARGNSSETSHSVPEAKGSKEV--EVTLVRKDKG--RQKTTRSRRKRNTN 2345
                   D      +S +  H++ +   S E   ++T   + +G   + +T++ R  +T+
Sbjct: 1979 RSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTS 2038

Query: 2346 KKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQS---------EKPHSTPPQ 2396
                   E  +  + QA   S   ++       ++P E +Q          E  H     
Sbjct: 2039 TYCYETAEK-ITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTEL 2097

Query: 2397 SCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPP----QPAPVDEEPQARFRVHS 2452
            S  S ++  P    +S+E + E   P   S     PPPP    Q    DE P       S
Sbjct: 2098 S-PSFINPNPLEWFASEEPTEESEKPLTQS--GGAPPPPGGKQQGRQCDETPPT-----S 2149

Query: 2453 IIESDPVTPPSDPSIPIPTLPSVTA-AKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQ 2511
            + ES P    SD        PS+TA A +     S  IP  +  T   + +     P   
Sbjct: 2150 VSESAPSQTDSDVPPETEECPSITADANIDSEDESETIP--TDKTVTYKHMDPPPAPVQD 2207

Query: 2512 STPSPALPPDTKASDVDTSSSTLRKIL---MDPKYVSATSVTSTSVTTAIAEPVSAAPCL 2568
             +PSP  P     S VD  +  + + L   +       T        T  + PV  +   
Sbjct: 2208 RSPSPRHP---DVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSD-- 2262

Query: 2569 HEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKIT 2619
                       KPL     P     S  + S V     KE V     P  T
Sbjct: 2263 --------GKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTT 2305



 Score = 42.4 bits (98), Expect = 0.009
 Identities = 51/231 (22%), Positives = 91/231 (39%), Gaps = 37/231 (16%)

Query: 2235 APPPYPGESQ---TDLQPPAGAQALQPSEEGM----ETDE--AVSGILETEAATESSRPP 2285
            APPP  G+ Q    D  PP       PS+       ET+E  +++     ++  ES   P
Sbjct: 2129 APPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIP 2188

Query: 2286 VNAP------DPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKD-KGRQKTTRS 2338
             +        DP   P   +       + S   PEA   ++     ++KD K + KT   
Sbjct: 2189 TDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKT--- 2245

Query: 2339 RRKRNTNKKVVAPVESH------VPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHS 2392
             +K  T  K  +PV+        +  S +  G   ++++ + V  P+  +  +++ KP +
Sbjct: 2246 -KKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTT 2304

Query: 2393 TPPQSCTSDLSKIPSTENSSQEISVEE-----------RTPTKASVPPDLP 2432
            TP         K   T+N++   + +            +T   ++VPP LP
Sbjct: 2305 TPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGLP 2355



 Score = 40.4 bits (93), Expect = 0.033
 Identities = 64/286 (22%), Positives = 97/286 (33%), Gaps = 27/286 (9%)

Query: 3178 LVMQSEYRLHPYTV-------PRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPG 3230
            LV   EY+ HP T        P  +        T  SE+P    G    PP  K   +  
Sbjct: 2084 LVSSCEYK-HPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQC 2142

Query: 3231 KEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVT 3290
             E   T  +++AP+ T + VP   P     P+   +A I      ++ + +P    V   
Sbjct: 2143 DETPPTSVSESAPSQTDSDVP---PETEECPSITADANI---DSEDESETIPTDKTVTYK 2196

Query: 3291 HGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPE-GE 3349
            H         +     R+ D+    P A         A    L  +TKT   G   +   
Sbjct: 2197 HMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSS 2256

Query: 3350 PLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQ-VSQEAKGTQT-------GVEQ 3401
            P++          A P P        +  +  S K  + V + AK T T       G E+
Sbjct: 2257 PVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEK 2316

Query: 3402 PRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSL 3447
             +     AN       +     A  GP +  +  S ++ P LPV L
Sbjct: 2317 DKETKNAANASASKSAKT----ATAGPGTTKTTKSSAVPPGLPVYL 2358


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
            [Homo sapiens]
          Length = 1451

 Score = 91.3 bits (225), Expect = 2e-17
 Identities = 234/1163 (20%), Positives = 415/1163 (35%), Gaps = 160/1163 (13%)

Query: 1639 PPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLE 1698
            P  V+    +S+      ++ +  VE     +   V+ ++VS +  PA + APAP +  +
Sbjct: 188  PGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGD 247

Query: 1699 QV-DLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQ 1757
                +  GA P  + A  P   EE  S ++    + + P    S  +A   +       +
Sbjct: 248  VTPQVKGGALPPAKRAKKPE--EESESSEEGSESEEEAPAGTRSQVKASEKI----LQVR 301

Query: 1758 PLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKK 1817
              S PA+ +       A    A A A      K E   ES    S D E + P A   K 
Sbjct: 302  AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAA---KA 358

Query: 1818 PNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITR 1877
              ++K S    Q  A S   K   RK           + +P G+    +      ++   
Sbjct: 359  LLQAKASGKTSQVGAASAPAKESPRKG---------AAPAPPGKTGPAVAKAQAGKREED 409

Query: 1878 TASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERE 1937
            + S +  +D E   P+      +   VR+  A         P K   E PR         
Sbjct: 410  SQSSSEESDSEEEAPAQAKPSGKAPQVRAASA---------PAK---ESPR--------- 448

Query: 1938 LQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQG 1997
                 A P  PR+  P   + +  ++EE+      E+    +  R   +   AA   P G
Sbjct: 449  ---KGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES----DSDREALAAMNAAQVKPLG 501

Query: 1998 KKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPET 2057
            K     P+V   +P +T  +GP +G     + P        S Q    ++          
Sbjct: 502  K----SPQV---KPASTMGMGP-LGKGAGPVPPGKVGPATPSAQVGKWEE---------- 543

Query: 2058 APVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVV 2117
                  + + + E++S S  G    + +A  +  SL N+  A  P  + A+   +++G V
Sbjct: 544  ------DSESSSEESSDSSDGEVPTA-VAPAQEKSLGNILQA-KPTSSPAKGPPQKAGPV 595

Query: 2118 AVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPS---PEATQLAKQMELEQA 2174
            AV   K+E P  ++  SS+  SD  D ++ P     + + P+   P+     K+     +
Sbjct: 596  AVQ-VKAEKPM-DNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTAS 653

Query: 2175 VEHI-AKLAEASASAAYKADAPEGLAPE---DRDKPAHQASETE----------LAAAIG 2220
             +    ++   +   A  A +P G +P       +PA  +S +E          LA  +G
Sbjct: 654  AKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG 713

Query: 2221 ---SIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEA 2277
               S+   +  +  + P        +   L    G    Q   E  E         ++E+
Sbjct: 714  QAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE---------DSES 764

Query: 2278 ATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTR 2337
            + E S     A  P+   T  K+ +  ++  +   P AKG+            G+  T  
Sbjct: 765  SEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA--------PGKVVTAA 816

Query: 2338 SRRKRNTNKKVVAPVESHVPESNQAQGESPAANEG----TTVQHPEAPQEEKQSEKPHST 2393
            ++ K+ +  KV  PV +    +  A+G +   + G    T  Q    P+E+  S +  S 
Sbjct: 817  AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD 876

Query: 2394 PPQSCTSDLSKIPS--TENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVH 2451
              +   +     PS  T      ++  + +P K + P    PP +  P     QA  +  
Sbjct: 877  SEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAP---TPPGKTGP--SAAQAGKQDD 931

Query: 2452 SIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQ 2511
            S   S+     SD   P     +VT+A++  P      P++SP            + +A 
Sbjct: 932  SGSSSE--ESDSDGEAP----AAVTSAQVIKPPLIFVDPNRSPAGPA----ATPAQAQAA 981

Query: 2512 STPSPALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEA 2571
            STP  A   ++ A    + S        D   + AT   +  + T +    +A P +  A
Sbjct: 982  STPRKARASESTARSSSSESE-------DEDVIPATQCLTPGIRTNVVTMPTAHPRI--A 1032

Query: 2572 PPPPVDSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDL 2631
            P   +      +E +        E  A++V  A       P  +P+ TSV ++    +  
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVDSAVG---TLPATSPQSTSVQAKGTNKLRK 1089

Query: 2632 ENSQKITLAKPAPQTL--------TGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLV 2683
                ++  A  AP++         +   S   G         + L GP      TL    
Sbjct: 1090 PKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEET 1149

Query: 2684 STPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVN-------AAPGTVNAAASAVNATA 2736
            +  +   +V+    ++L+G +    TP N+             +   T+ A         
Sbjct: 1150 AAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQE 1209

Query: 2737 SAVTVTAGAVTAASGGVTATTGT 2759
            +     AG ++  +GG  A +GT
Sbjct: 1210 AKPQQAAGMLSPKTGGKEAASGT 1232



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 189/949 (19%), Positives = 331/949 (34%), Gaps = 158/949 (16%)

Query: 1595 QKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSAL 1654
            ++E++     +E + +E+     K    AP+ + +      S    +      ++ P+A 
Sbjct: 405  KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA 464

Query: 1655 EKTTGDKTVEAPLVTEEK-------------TVEPATVSEEAKPASEPAPAPVEQLEQVD 1701
            +   G +  ++   +EE               V+P   S + KPAS     P+ +     
Sbjct: 465  QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGK-GAGP 523

Query: 1702 LPPG-ADPDKEAAMMPAGVE--EGSSGDQPPYLDAKPPTPGASFSQAE-SNVDPEPDSTQ 1757
            +PPG   P   +A +    E  E SS +     D + PT  A   +    N+     ++ 
Sbjct: 524  VPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSS 583

Query: 1758 PLSKPAQKS-EEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDK 1816
            P   P QK+   A + KAEKP   +++  +++  A++  E  P A    +  P +     
Sbjct: 584  PAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADS--EEAPAAMTAAQAKPALKIPQT 641

Query: 1817 KPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKIT 1876
            K    K + T    A+  +    V  ++ R    K   + SP G +  +       ++  
Sbjct: 642  KACPKKTNTT----ASAKVAPVRVGTQAPR----KAGTATSPAGSSPAVAG---GTQRPA 690

Query: 1877 RTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLER 1936
              +S +  +D E  +  L ++  +    +SV   +       PVK  + Q          
Sbjct: 691  EDSSSSEESDSEEEKTGLAVTVGQ---AKSVGKGLQVKAASVPVKGSLGQ---------- 737

Query: 1937 ELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQ 1996
                    P  P +  P  T+ +A+++E++E+ E  E     E   SP   KT+      
Sbjct: 738  -----GTAPVLPGKTGPTVTQVKAEKQEDSESSE--EESDSEEAAASPAQVKTS------ 784

Query: 1997 GKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPE 2056
                                      VK++  +   A   A S +       GT   P +
Sbjct: 785  --------------------------VKKTQAKANPAAARAPSAK-------GTISAPGK 811

Query: 2057 TAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGV 2116
                    K+ +P K     R   +NS +     AS+ +V  AV+    A    E +SG 
Sbjct: 812  VVTAAAQAKQRSPSKVKPPVR-NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG- 869

Query: 2117 VAVSPEKSESPQ--------KEDGLSSQLKSDPVDPDKEPEKEDVSASGP---SPEATQL 2165
               S E+S+S +        K  G + Q+++  + P KE  ++  + + P    P A Q 
Sbjct: 870  --SSEEESDSEEEAETLAQVKPSGKTHQIRA-ALAPAKESPRKGAAPTPPGKTGPSAAQA 926

Query: 2166 AKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIIND 2225
             KQ              + S S++ ++D+       D + PA   S   +   +  I  D
Sbjct: 927  GKQ--------------DDSGSSSEESDS-------DGEAPAAVTSAQVIKPPL--IFVD 963

Query: 2226 ISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGI------LETEAAT 2279
             +  P    A P     + T  +  A     + S    E ++ +         + T   T
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023

Query: 2280 ESSRPPVNAPDPS-AGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRS 2338
              +  P  AP  S AG + +KE+   S       P  +    V        +      + 
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKG 1083

Query: 2339 RRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSC 2398
              K    K       +  PES+    +S  ++ G+  +  E PQ  K S      P  S 
Sbjct: 1084 TNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSE-EDGEGPQGAK-SAHTLVGPTPSR 1141

Query: 2399 TSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPA-----PVDEEPQARFRVHSI 2453
            T  L +  + E+S  ++    ++     + P L P    A      +D  P         
Sbjct: 1142 TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSV------- 1194

Query: 2454 IESDPVTPPSDPSIPIPTLPSVTAAKLSP-----PVASGGIPHQSPPTK 2497
              S  +    DP       P   A  LSP       ASG  P +S   K
Sbjct: 1195 --SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPK 1241



 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 211/1012 (20%), Positives = 350/1012 (34%), Gaps = 141/1012 (13%)

Query: 1935 ERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGG 1994
            +R+ +E AA+     R   P +   + EEEE    E A+         +PR   T +   
Sbjct: 62   KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKA--------TPRLASTNSS-- 111

Query: 1995 PQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGS--EQKRDRKDAGTDK 2052
                 G + P     + +A TE   + G   +SM   A  +   +    K  RK A    
Sbjct: 112  ---VLGADLPSSMKEKAKAETEKAGKTG---NSMPHPATGKTVANLLSGKSPRKSAEPSA 165

Query: 2053 NPPETAPVEVVEKKPAPEKNSKSKRGR---SRNSRLAVDKSASLKNVDAAVSPRGAAAQA 2109
            N   T   E  E+   P   + +K G     +    + D S+S    D    P    AQ 
Sbjct: 166  NT--TLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223

Query: 2110 GERESGVVAVSPEKSESPQ--KEDGLSSQLKSDPVDPDK---EPEKEDVSAS-GPSPEAT 2163
             +  S     SP +  +P   K   ++ Q+K   + P K   +PE+E  S+  G   E  
Sbjct: 224  -KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEE 282

Query: 2164 QLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSII 2223
              A      +A E I ++  ASA A  K    +G  P    K    AS+T+         
Sbjct: 283  APAGTRSQVKASEKILQVRAASAPA--KGTPGKGATPAPPGKAGAVASQTK--------- 331

Query: 2224 NDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSR 2283
               +G+PE   +       S ++ + PA    LQ    G  +    +     E+  + + 
Sbjct: 332  ---AGKPEE-DSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387

Query: 2284 PPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRN 2343
            P   AP    GP   K   G   E S S  E   S+E                       
Sbjct: 388  P---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEE----------------------- 421

Query: 2344 TNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLS 2403
                         P   +  G++P      +    E+P++      P  T P +    + 
Sbjct: 422  -----------EAPAQAKPSGKAPQVR-AASAPAKESPRKGAAPAPPRKTGPAAAQVQVG 469

Query: 2404 KIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIE-SDPVTP- 2461
            K      SS E S  +R    A     + P  +   V  +P +   +  + + + PV P 
Sbjct: 470  KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV--KPASTMGMGPLGKGAGPVPPG 527

Query: 2462 ---PSDPSIPIPTLP--SVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSP 2516
               P+ PS  +      S ++++ S   + G +P    P +     +     +A+ T SP
Sbjct: 528  KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK---SLGNILQAKPTSSP 584

Query: 2517 ALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPV 2576
            A  P  KA  V              K +  +  +  S  +A +E   AA    +A P   
Sbjct: 585  AKGPPQKAGPVAVQVKA-------EKPMDNSESSEESSDSADSEEAPAAMTAAQAKP--- 634

Query: 2577 DSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPV--------S 2628
             + K  + K  P  TN +   AS  +        AP  A   TS     P         +
Sbjct: 635  -ALKIPQTKACPKKTNTT---ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 690

Query: 2629 IDLENSQKITLAKPAPQTLTGLVSALTGLVNVSL-VPVNALKGPVKGSVTTLKSLVSTPA 2687
             D  +S++      + +  TGL   +    +V   + V A   PVKGS+           
Sbjct: 691  EDSSSSEE----SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ--------- 737

Query: 2688 GPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVT 2747
            G   VL G     TGP               +        AA++     ++V  T     
Sbjct: 738  GTAPVLPGK----TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793

Query: 2748 AASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRF-HPGSMPVIDDRPA---DAGSG 2803
             A+    +  GT++  G V+  + + KQR+ +       +P +  V+   PA     G  
Sbjct: 794  PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKA 853

Query: 2804 AGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTA 2863
                     G    S S ++    +  +  ++Q+ P S    + + +++ ++  P    A
Sbjct: 854  VATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKP-SGKTHQIRAALAPAKESPRKGAA 912

Query: 2864 SQPPSK-GPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEP 2914
              PP K GP A        + S+   +     A   ++S +  +P L   +P
Sbjct: 913  PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDP 964



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 99/475 (20%), Positives = 176/475 (37%), Gaps = 49/475 (10%)

Query: 1609 KQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKT--TGDKTVEAP 1666
            + ED +  P T    P  + + + T P+  P      ++  A S+ E +  +  K  E P
Sbjct: 1000 ESEDEDVIPATQCLTPGIR-TNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGP 1058

Query: 1667 LVTEEKTV------EPATVSEEAKPASEPAPAPVEQLEQVD-LPPGADPDKEAAMMPAGV 1719
                +  V       P + S +AK  ++     + +++Q    P  +D  ++++   +G 
Sbjct: 1059 ATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGS 1118

Query: 1720 EEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPL-SKPAQKSEEANEPKAEKPD 1778
            EE   G Q           GA    A + V P P  T+ L  + A +S E +     +  
Sbjct: 1119 EEDGEGPQ-----------GAK--SAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSL 1165

Query: 1779 ATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEK 1838
             +    P        A ++ P       V   +AAKD    K +    P QAA +     
Sbjct: 1166 LSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAK--PQQAAGML---S 1220

Query: 1839 PVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSR 1898
            P T   E       ++S  P+  A           + +  A +++       +P  PL+ 
Sbjct: 1221 PKTGGKEAASGTTPQKSRKPKKGAGN--------PQASTLALQSNITQCLLGQP-WPLNE 1271

Query: 1899 TR-RRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTR 1957
             + + +V  V   + + E +  V    E  R   +  +R+L        TPR     K +
Sbjct: 1272 AQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRS----KKK 1327

Query: 1958 RRADEEEENEAKEPAETLKPPEGWRSPRSQ-----KTAAGGGPQGKKG-KNEPKVDATRP 2011
            ++    E  EA    E        ++ R +     K   G G  G +G K+EP+ +  + 
Sbjct: 1328 KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKG 1387

Query: 2012 EATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKK 2066
              T E G Q   K    + K+ + +   E+K  +K A         +P +  +KK
Sbjct: 1388 MGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKK 1442



 Score = 56.2 bits (134), Expect = 6e-07
 Identities = 171/897 (19%), Positives = 296/897 (32%), Gaps = 103/897 (11%)

Query: 1598 KEKDQKPKEVEKQEDTENHPKTPESAPENKDS-ELKTPPSV-----GPPSVTVVTLESAP 1651
            K   QK   V  Q   E      ES+ E+ DS + +  P+        P++ +   ++ P
Sbjct: 586  KGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACP 645

Query: 1652 SALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPA-SEPAPAPVEQLEQVDLPPGADPDK 1710
                 T   K     + T+     P        PA S PA A   Q    D     + D 
Sbjct: 646  KKTNTTASAKVAPVRVGTQA----PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701

Query: 1711 EAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPL--SKPAQKSEE 1768
            E       V  G +      L  K  +     S  +      P  T P      A+K E+
Sbjct: 702  EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 761

Query: 1769 ANEPKAEKPDATADAEP------------DANQKAEAAPESQPPASEDLEVDPPVA-AKD 1815
            +   + E     A A P             AN  A  AP ++   S   +V    A AK 
Sbjct: 762  SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 821

Query: 1816 KKPNKSKRSKTPVQAAAV---------SIVEKPVTRKSERIDREKLKRSNSPRGEAQKLL 1866
            + P+K K      Q + V         S+ +   T    +   E+   S+    ++++  
Sbjct: 822  RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881

Query: 1867 ELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQ 1926
            E   + +   +T    +A       P    + T         A  G  ++     E  + 
Sbjct: 882  ETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDS 941

Query: 1927 PRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRS 1986
                         EA A  T+ +  +PP      +      A  PA+        ++  S
Sbjct: 942  DG-----------EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARAS 990

Query: 1987 QKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRK 2046
            + TA     + +     P      P   T V   +      + PKA+   A S ++  R 
Sbjct: 991  ESTARSSSSESEDEDVIPATQCLTPGIRTNV-VTMPTAHPRIAPKASMAGASSSKESSRI 1049

Query: 2047 DAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNS----RLAVDKSASLKNVDAAVSP 2102
              G  +  P T     V   PA    S S + +  N     +L   + A+     +  S 
Sbjct: 1050 SDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSE 1109

Query: 2103 RGAAAQAGERESG-----------VVAVSPEKSESPQKEDGLSSQ----------LKSDP 2141
              + + +G  E G           +V  +P ++E+  +E    S           L S  
Sbjct: 1110 DSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGY 1169

Query: 2142 VDPDKEPEKEDVSA------SGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKA--- 2192
            + P   P     S       S PS  +T  AK    +   +  AK  +A+   + K    
Sbjct: 1170 MTPGLTPANSQASKATPKLDSSPSVSSTLAAKD---DPDGKQEAKPQQAAGMLSPKTGGK 1226

Query: 2193 DAPEGLAPEDRDKPAHQASETELA--AAIGSIINDISGEPENFPAPPPYPGESQTDLQPP 2250
            +A  G  P+   KP   A   + +  A   +I   + G+P      P    + Q  +   
Sbjct: 1227 EAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPW-----PLNEAQVQASVVKV 1281

Query: 2251 AGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAG-PTDTKEARGNSSETS 2309
                  Q  ++ ++T +  S         ES +  ++   P+A  P   K+ +  + E  
Sbjct: 1282 LTELLEQERKKVVDTTKESS-----RKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGG 1336

Query: 2310 HSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAA 2369
                EA  S E   T  +    R K +   +++     + +      PE    +G     
Sbjct: 1337 ----EASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTV- 1391

Query: 2370 NEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKAS 2426
             EG    +P++ +E+K+S+K      +      +K  ST++S      +++   K +
Sbjct: 1392 -EGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTA 1447



 Score = 43.5 bits (101), Expect = 0.004
 Identities = 88/327 (26%), Positives = 129/327 (39%), Gaps = 47/327 (14%)

Query: 1557 SGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENH 1616
            S RI   +  EG  +  DS    V    +   + T +Q K   K +KPK  E Q+ T   
Sbjct: 1046 SSRISDGKKQEGPATQVDSA---VGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQAT--- 1099

Query: 1617 PKTPESAPENKDSELKTPPS----------------VGP-PSVTVVTLESAPSALEKTTG 1659
             K PES+ +++DS   +  S                VGP PS T   +E   +A E +  
Sbjct: 1100 -KAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEE--TAAESSED 1156

Query: 1660 DKTVEAP---LVTEEKT--VEPA-TVSEEAKPASEPAPAPVEQLEQVDLPPG---ADPDK 1710
            D  V AP   L++   T  + PA + + +A P  + +P+    L   D P G   A P +
Sbjct: 1157 D--VVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQ 1214

Query: 1711 EAAMM--PAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEE 1768
             A M+    G +E +SG  P    ++ P  GA   QA S +  + + TQ L        E
Sbjct: 1215 AAGMLSPKTGGKEAASGTTPQ--KSRKPKKGAGNPQA-STLALQSNITQCLLGQPWPLNE 1271

Query: 1769 ANEPKAEKPDATADAEPDANQKAEAAPESQPPASED----LEVDPPVAAKDKKPNKSKRS 1824
            A    +     T   E +  +  +   ES     E     L  D P A   +   K K  
Sbjct: 1272 AQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLG 1331

Query: 1825 KTPVQAAAVSIVEKPVTRKSERIDREK 1851
                  A+VS  EK  T    +  R+K
Sbjct: 1332 AGEGGEASVS-PEKTSTTSKGKAKRDK 1357



 Score = 39.7 bits (91), Expect = 0.056
 Identities = 91/415 (21%), Positives = 149/415 (35%), Gaps = 79/415 (19%)

Query: 803  ERERRLIRKEKVEKDKTDKQKRKGKVHSP--SSQSSETDQENEREQSPEKPRSCN----- 855
            ++   L RK K E+D    Q +K +V  P  +S+SSE ++E E E +   PR  +     
Sbjct: 54   QQTSELGRKRKAEEDAA-LQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSV 112

Query: 856  -------------KLSREKADKEGIA-----------------KNRLELMPCVVLTRVKE 885
                         K   EKA K G +                   R    P    T V E
Sbjct: 113  LGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSE 172

Query: 886  KE--------GKVIDHTPVEKLKAKLDNDTVKSSA----LDQKLQVSQTEPAKSDLSKLE 933
             E        G       V   +A   ++   SS+    ++ K  V   +   S +S  E
Sbjct: 173  TEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKE 232

Query: 934  SVRMKVPKEKGLSSHVEVVEKEGRL-KARKHLKPEQPADGVSAVDLEKLEARKRRFADSN 992
            S   K     G    V    K G L  A++  KPE+ ++  S+ +  + E        S 
Sbjct: 233  SPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESE--SSEEGSESEEEAPAGTRSQ 290

Query: 993  LKAEKQKPEVKKSS--------------PEMEDARVLSKK---QPDVSSREVILLREGEA 1035
            +KA ++  +V+ +S              P  +   V S+    +P+  S           
Sbjct: 291  VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350

Query: 1036 ERKPVRKEILKRESKKIKLDRLNTVASP-KDCQELASISVGSGSRPSSDLQARLG---EL 1091
            E  P  K +L+ ++   K  ++   ++P K+     +     G    +  +A+ G   E 
Sbjct: 351  EETPAAKALLQAKASG-KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED 409

Query: 1092 AGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSG 1146
            +  S E  + + + P  +KP  K  QV     P +E  RK         P RK+G
Sbjct: 410  SQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA----PAPPRKTG 460



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 34/139 (24%), Positives = 58/139 (41%), Gaps = 29/139 (20%)

Query: 223 DITREVRG------RRPERNYQHSRSRSPHSSQSRNQSPQRLASQ------------ASR 264
           D+T +V+G      +R ++  + S S S   S+S  ++P    SQ            AS 
Sbjct: 247 DVTPQVKGGALPPAKRAKKPEEESES-SEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305

Query: 265 PTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDS--------PARSVQSAAVP 316
           P +   G G+           +S + +    + S SSS++S         A+++  A   
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365

Query: 317 APTSQL--LSSLEKDEPRK 333
             TSQ+   S+  K+ PRK
Sbjct: 366 GKTSQVGAASAPAKESPRK 384


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
            sapiens]
          Length = 1450

 Score = 90.1 bits (222), Expect = 4e-17
 Identities = 232/1083 (21%), Positives = 381/1083 (35%), Gaps = 112/1083 (10%)

Query: 1639 PPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLE 1698
            P  V+    +S+      ++ +  VE     +   V+ ++VS +  PA + APAP +  +
Sbjct: 188  PGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGD 247

Query: 1699 QV-DLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQ 1757
                +  GA P  + A  P   EE  S ++    + + P    S  +A   +       +
Sbjct: 248  VTPQVKGGALPPAKRAKKPE--EESESSEEGSESEEEAPAGTRSQVKASEKI----LQVR 301

Query: 1758 PLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKK 1817
              S PA+ +       A    A A A      K E   ES    S D E + P A   K 
Sbjct: 302  AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAA---KA 358

Query: 1818 PNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITR 1877
              ++K S    Q  A S   K   RK           + +P G+    +      ++   
Sbjct: 359  LLQAKASGKTSQVGAASAPAKESPRKG---------AAPAPPGKTGPAVAKAQAGKREED 409

Query: 1878 TASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERE 1937
            + S +  +D E   P+      +   VR+  A   +   +     P   PR T       
Sbjct: 410  SQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAP---PRKTG------ 460

Query: 1938 LQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAA-GGGPQ 1996
               AA V    +      +   +D + E  A   A  +KP    +SP+ +  +  G GP 
Sbjct: 461  -PAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL--GKSPQVKPASTMGMGPL 517

Query: 1997 GKKGKNEP--KVDATRPEATTEVGPQIGVKESSMEPKA-------------AEEEAGSEQ 2041
            GK     P  KV    P A  +VG      ESS E  +             A+E++    
Sbjct: 518  GKGAGPVPPGKVGPATPSA--QVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575

Query: 2042 KRDRKDAGTDKNPPETA---PVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDA 2098
             + +  +   K PP+ A    V+V  +KP     S  +   S +S  A     + +   A
Sbjct: 576  LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPA 635

Query: 2099 AVSPRGAAAQAGERESGVVAVSPEK--SESPQKEDGLSSQLKSDP--VDPDKEPEKEDVS 2154
               P+  A       +    V+P +  +++P+K    +S   S P      + P ++  S
Sbjct: 636  LKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSS 695

Query: 2155 ASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETE 2214
            +     E  +    + + QA      L   +AS   K    +G AP    K     ++ +
Sbjct: 696  SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVK 755

Query: 2215 LAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPPAG-AQALQPSEEGMETDEAVSGIL 2273
                  S  ++   + E   A P     S    Q  A  A A  PS +G     +  G +
Sbjct: 756  AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKG---TISAPGKV 812

Query: 2274 ETEAATESSRPPVNAPDPSAGP-TDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKG- 2331
             T AA    R P     P   P   T  ARG +S    SV +A  +     T   +D G 
Sbjct: 813  VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP--SVGKAVATAAQAQTGPEEDSGS 870

Query: 2332 RQKTTRSRRKRNTNKKVVAPVESHVPESNQAQG-ESPAANEGTT---VQHPEAPQEEKQS 2387
             ++ + S  +  T  +V    ++H   +  A   ESP      T      P A Q  KQ 
Sbjct: 871  SEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQD 930

Query: 2388 EKPHSTPPQSCTSDLSKIPSTENSSQEISV------EERTPT-KASVPPDLPPPPQPAPV 2440
            +   S+  +   SD  + P+   S+Q I          R+P   A+ P        P   
Sbjct: 931  DSGSSS--EESDSD-GEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKA 987

Query: 2441 DEEPQARFRVHSIIESDPVTPPSDPSIP-----IPTLPSVTAAKLSPPVASGGIPHQSPP 2495
                       S  E + V P +    P     + T+P+    +++P  +  G       
Sbjct: 988  RASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPT-AHPRIAPKASMAGASSSKES 1046

Query: 2496 TKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSSTLRKILMD--PKYVSAT------ 2547
            +++++   +QE P  Q   +    P T        +    K+     P+   AT      
Sbjct: 1047 SRISDG-KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESS 1105

Query: 2548 -----SVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTNNSEIQASEVL 2602
                 S  S+S +    E    A   H   P P    + L E+TA   + +  +  S+ L
Sbjct: 1106 DDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTP-SRTETLVEETAAESSEDDVVAPSQSL 1164

Query: 2603 VAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLA---------KPAPQTLTGLVSA 2653
            ++     + P + P   S  S+    +D   S   TLA         +  PQ   G++S 
Sbjct: 1165 LSG---YMTPGLTP-ANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSP 1220

Query: 2654 LTG 2656
             TG
Sbjct: 1221 KTG 1223



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 189/949 (19%), Positives = 332/949 (34%), Gaps = 159/949 (16%)

Query: 1595 QKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSAL 1654
            ++E++     +E + +E+     K    AP+ + +      S    +      ++ P+A 
Sbjct: 405  KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA 464

Query: 1655 EKTTGDKTVEAPLVTEEK-------------TVEPATVSEEAKPASEPAPAPVEQLEQVD 1701
            +   G +  ++   +EE               V+P   S + KPAS     P+ +     
Sbjct: 465  QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGK-GAGP 523

Query: 1702 LPPG-ADPDKEAAMMPAGVE--EGSSGDQPPYLDAKPPTPGASFSQAE-SNVDPEPDSTQ 1757
            +PPG   P   +A +    E  E SS +     D + PT  A   +    N+     ++ 
Sbjct: 524  VPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSS 583

Query: 1758 PLSKPAQKS-EEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDK 1816
            P   P QK+   A + KAEKP   +++  +++  A++  E  P A    +  P +     
Sbjct: 584  PAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADS--EEAPAAMTAAQAKPALKIPQT 641

Query: 1817 KPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKIT 1876
            K    K + T    A+  +    V  ++ R    K   + SP G +  +       ++  
Sbjct: 642  KACPKKTNTT----ASAKVAPVRVGTQAPR----KAGTATSPAGSSPAVAG---GTQRPA 690

Query: 1877 RTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLER 1936
              +S +  +D E  +  L ++  +    +SV   +       PVK  + Q          
Sbjct: 691  EDSSSSEESDSEEEKTGLAVTVGQ---AKSVGKGLQVKAASVPVKGSLGQ---------- 737

Query: 1937 ELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQ 1996
                    P  P +  P  T+ +A+++E++E+ E  E     E   SP   KT+      
Sbjct: 738  -----GTAPVLPGKTGPTVTQVKAEKQEDSESSE--EESDSEEAAASPAQVKTS------ 784

Query: 1997 GKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPE 2056
                                      VK++  +   A   A S +       GT   P +
Sbjct: 785  --------------------------VKKTQAKANPAAARAPSAK-------GTISAPGK 811

Query: 2057 TAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGV 2116
                    K+ +P K     R   +NS +     AS+ +V  AV+    A    E +SG 
Sbjct: 812  VVTAAAQAKQRSPSKVKPPVR-NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG- 869

Query: 2117 VAVSPEKSESPQ--------KEDGLSSQLKSDPVDPDKEPEKEDVSASGP---SPEATQL 2165
               S E+S+S +        K  G + Q+++  + P KE  ++  + + P    P A Q 
Sbjct: 870  --SSEEESDSEEEAETLAQVKPSGKTHQIRA-ALAPAKESPRKGAAPTPPGKTGPSAAQA 926

Query: 2166 AKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIIND 2225
             KQ              + S S++ ++D+       D + PA   S   +   +  I  D
Sbjct: 927  GKQ--------------DDSGSSSEESDS-------DGEAPAAVTSAQVIKPPL--IFVD 963

Query: 2226 ISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGI------LETEAAT 2279
             +  P    A P     + T  +  A     + S    E ++ +         + T   T
Sbjct: 964  PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023

Query: 2280 ESSRPPVNAPDPS-AGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRS 2338
              +  P  AP  S AG + +KE+   S       P  +    V        +      + 
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKG 1083

Query: 2339 RRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSC 2398
              K    K       +  PES+    +S  ++ G+  +  E PQ  K +     TP  S 
Sbjct: 1084 TNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSE-EDGEGPQGAKSAHTLGPTP--SR 1140

Query: 2399 TSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPA-----PVDEEPQARFRVHSI 2453
            T  L +  + E+S  ++    ++     + P L P    A      +D  P         
Sbjct: 1141 TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSV------- 1193

Query: 2454 IESDPVTPPSDPSIPIPTLPSVTAAKLSP-----PVASGGIPHQSPPTK 2497
              S  +    DP       P   A  LSP       ASG  P +S   K
Sbjct: 1194 --SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPK 1240



 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 211/1012 (20%), Positives = 350/1012 (34%), Gaps = 141/1012 (13%)

Query: 1935 ERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGG 1994
            +R+ +E AA+     R   P +   + EEEE    E A+         +PR   T +   
Sbjct: 62   KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKA--------TPRLASTNSS-- 111

Query: 1995 PQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGS--EQKRDRKDAGTDK 2052
                 G + P     + +A TE   + G   +SM   A  +   +    K  RK A    
Sbjct: 112  ---VLGADLPSSMKEKAKAETEKAGKTG---NSMPHPATGKTVANLLSGKSPRKSAEPSA 165

Query: 2053 NPPETAPVEVVEKKPAPEKNSKSKRGR---SRNSRLAVDKSASLKNVDAAVSPRGAAAQA 2109
            N   T   E  E+   P   + +K G     +    + D S+S    D    P    AQ 
Sbjct: 166  NT--TLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223

Query: 2110 GERESGVVAVSPEKSESPQ--KEDGLSSQLKSDPVDPDK---EPEKEDVSAS-GPSPEAT 2163
             +  S     SP +  +P   K   ++ Q+K   + P K   +PE+E  S+  G   E  
Sbjct: 224  -KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEE 282

Query: 2164 QLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSII 2223
              A      +A E I ++  ASA A  K    +G  P    K    AS+T+         
Sbjct: 283  APAGTRSQVKASEKILQVRAASAPA--KGTPGKGATPAPPGKAGAVASQTK--------- 331

Query: 2224 NDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSR 2283
               +G+PE   +       S ++ + PA    LQ    G  +    +     E+  + + 
Sbjct: 332  ---AGKPEE-DSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387

Query: 2284 PPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRN 2343
            P   AP    GP   K   G   E S S  E   S+E                       
Sbjct: 388  P---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEE----------------------- 421

Query: 2344 TNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLS 2403
                         P   +  G++P      +    E+P++      P  T P +    + 
Sbjct: 422  -----------EAPAQAKPSGKAPQVR-AASAPAKESPRKGAAPAPPRKTGPAAAQVQVG 469

Query: 2404 KIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIE-SDPVTP- 2461
            K      SS E S  +R    A     + P  +   V  +P +   +  + + + PV P 
Sbjct: 470  KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV--KPASTMGMGPLGKGAGPVPPG 527

Query: 2462 ---PSDPSIPIPTLP--SVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSP 2516
               P+ PS  +      S ++++ S   + G +P    P +     +     +A+ T SP
Sbjct: 528  KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK---SLGNILQAKPTSSP 584

Query: 2517 ALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPV 2576
            A  P  KA  V              K +  +  +  S  +A +E   AA    +A P   
Sbjct: 585  AKGPPQKAGPVAVQVKA-------EKPMDNSESSEESSDSADSEEAPAAMTAAQAKP--- 634

Query: 2577 DSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPV--------S 2628
             + K  + K  P  TN +   AS  +        AP  A   TS     P         +
Sbjct: 635  -ALKIPQTKACPKKTNTT---ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 690

Query: 2629 IDLENSQKITLAKPAPQTLTGLVSALTGLVNVSL-VPVNALKGPVKGSVTTLKSLVSTPA 2687
             D  +S++      + +  TGL   +    +V   + V A   PVKGS+           
Sbjct: 691  EDSSSSEE----SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ--------- 737

Query: 2688 GPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVT 2747
            G   VL G     TGP               +        AA++     ++V  T     
Sbjct: 738  GTAPVLPGK----TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793

Query: 2748 AASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRF-HPGSMPVIDDRPA---DAGSG 2803
             A+    +  GT++  G V+  + + KQR+ +       +P +  V+   PA     G  
Sbjct: 794  PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKA 853

Query: 2804 AGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTA 2863
                     G    S S ++    +  +  ++Q+ P S    + + +++ ++  P    A
Sbjct: 854  VATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKP-SGKTHQIRAALAPAKESPRKGAA 912

Query: 2864 SQPPSK-GPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEP 2914
              PP K GP A        + S+   +     A   ++S +  +P L   +P
Sbjct: 913  PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDP 964



 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 170/896 (18%), Positives = 295/896 (32%), Gaps = 102/896 (11%)

Query: 1598 KEKDQKPKEVEKQEDTENHPKTPESAPENKDS-ELKTPPSV-----GPPSVTVVTLESAP 1651
            K   QK   V  Q   E      ES+ E+ DS + +  P+        P++ +   ++ P
Sbjct: 586  KGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACP 645

Query: 1652 SALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPA-SEPAPAPVEQLEQVDLPPGADPDK 1710
                 T   K     + T+     P        PA S PA A   Q    D     + D 
Sbjct: 646  KKTNTTASAKVAPVRVGTQA----PRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701

Query: 1711 EAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPL--SKPAQKSEE 1768
            E       V  G +      L  K  +     S  +      P  T P      A+K E+
Sbjct: 702  EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 761

Query: 1769 ANEPKAEKPDATADAEP------------DANQKAEAAPESQPPASEDLEVDPPVA-AKD 1815
            +   + E     A A P             AN  A  AP ++   S   +V    A AK 
Sbjct: 762  SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 821

Query: 1816 KKPNKSKRSKTPVQAAAV---------SIVEKPVTRKSERIDREKLKRSNSPRGEAQKLL 1866
            + P+K K      Q + V         S+ +   T    +   E+   S+    ++++  
Sbjct: 822  RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881

Query: 1867 ELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQ 1926
            E   + +   +T    +A       P    + T         A  G  ++     E  + 
Sbjct: 882  ETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDS 941

Query: 1927 PRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRS 1986
                         EA A  T+ +  +PP      +      A  PA+        ++  S
Sbjct: 942  DG-----------EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARAS 990

Query: 1987 QKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRK 2046
            + TA     + +     P      P   T V   +      + PKA+   A S ++  R 
Sbjct: 991  ESTARSSSSESEDEDVIPATQCLTPGIRTNV-VTMPTAHPRIAPKASMAGASSSKESSRI 1049

Query: 2047 DAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNS----RLAVDKSASLKNVDAAVSP 2102
              G  +  P T     V   PA    S S + +  N     +L   + A+     +  S 
Sbjct: 1050 SDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSE 1109

Query: 2103 RGAAAQAGERESG----------VVAVSPEKSESPQKEDGLSSQ----------LKSDPV 2142
              + + +G  E G           +  +P ++E+  +E    S           L S  +
Sbjct: 1110 DSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYM 1169

Query: 2143 DPDKEPEKEDVSA------SGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKA---D 2193
             P   P     S       S PS  +T  AK    +   +  AK  +A+   + K    +
Sbjct: 1170 TPGLTPANSQASKATPKLDSSPSVSSTLAAKD---DPDGKQEAKPQQAAGMLSPKTGGKE 1226

Query: 2194 APEGLAPEDRDKPAHQASETELA--AAIGSIINDISGEPENFPAPPPYPGESQTDLQPPA 2251
            A  G  P+   KP   A   + +  A   +I   + G+P      P    + Q  +    
Sbjct: 1227 AASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPW-----PLNEAQVQASVVKVL 1281

Query: 2252 GAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAG-PTDTKEARGNSSETSH 2310
                 Q  ++ ++T +  S         ES +  ++   P+A  P   K+ +  + E   
Sbjct: 1282 TELLEQERKKVVDTTKESS-----RKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGG- 1335

Query: 2311 SVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAAN 2370
               EA  S E   T  +    R K +   +++     + +      PE    +G      
Sbjct: 1336 ---EASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTV-- 1390

Query: 2371 EGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKAS 2426
            EG    +P++ +E+K+S+K      +      +K  ST++S      +++   K +
Sbjct: 1391 EGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTA 1446



 Score = 46.6 bits (109), Expect = 5e-04
 Identities = 82/325 (25%), Positives = 123/325 (37%), Gaps = 44/325 (13%)

Query: 1557 SGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENH 1616
            S RI   +  EG  +  DS    V    +   + T +Q K   K +KPK  E Q+ T   
Sbjct: 1046 SSRISDGKKQEGPATQVDSA---VGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQAT--- 1099

Query: 1617 PKTPESAPENKDSELKTPPS----VGPPSV-TVVTLESAPSALEKTTGDKTVEAPLVTEE 1671
             K PES+ +++DS   +  S     GP    +  TL   PS  E    +   E+   +E+
Sbjct: 1100 -KAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAES---SED 1155

Query: 1672 KTVEPA----------------TVSEEAKPASEPAPAPVEQLEQVDLPPG---ADPDKEA 1712
              V P+                + + +A P  + +P+    L   D P G   A P + A
Sbjct: 1156 DVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAA 1215

Query: 1713 AMM--PAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEAN 1770
             M+    G +E +SG  P    ++ P  GA   QA S +  + + TQ L        EA 
Sbjct: 1216 GMLSPKTGGKEAASGTTPQ--KSRKPKKGAGNPQA-STLALQSNITQCLLGQPWPLNEAQ 1272

Query: 1771 EPKAEKPDATADAEPDANQKAEAAPESQPPASED----LEVDPPVAAKDKKPNKSKRSKT 1826
               +     T   E +  +  +   ES     E     L  D P A   +   K K    
Sbjct: 1273 VQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAG 1332

Query: 1827 PVQAAAVSIVEKPVTRKSERIDREK 1851
                A+VS  EK  T    +  R+K
Sbjct: 1333 EGGEASVS-PEKTSTTSKGKAKRDK 1356



 Score = 39.7 bits (91), Expect = 0.056
 Identities = 91/415 (21%), Positives = 149/415 (35%), Gaps = 79/415 (19%)

Query: 803  ERERRLIRKEKVEKDKTDKQKRKGKVHSP--SSQSSETDQENEREQSPEKPRSCN----- 855
            ++   L RK K E+D    Q +K +V  P  +S+SSE ++E E E +   PR  +     
Sbjct: 54   QQTSELGRKRKAEEDAA-LQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSV 112

Query: 856  -------------KLSREKADKEGIA-----------------KNRLELMPCVVLTRVKE 885
                         K   EKA K G +                   R    P    T V E
Sbjct: 113  LGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSE 172

Query: 886  KE--------GKVIDHTPVEKLKAKLDNDTVKSSA----LDQKLQVSQTEPAKSDLSKLE 933
             E        G       V   +A   ++   SS+    ++ K  V   +   S +S  E
Sbjct: 173  TEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKE 232

Query: 934  SVRMKVPKEKGLSSHVEVVEKEGRL-KARKHLKPEQPADGVSAVDLEKLEARKRRFADSN 992
            S   K     G    V    K G L  A++  KPE+ ++  S+ +  + E        S 
Sbjct: 233  SPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESE--SSEEGSESEEEAPAGTRSQ 290

Query: 993  LKAEKQKPEVKKSS--------------PEMEDARVLSKK---QPDVSSREVILLREGEA 1035
            +KA ++  +V+ +S              P  +   V S+    +P+  S           
Sbjct: 291  VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350

Query: 1036 ERKPVRKEILKRESKKIKLDRLNTVASP-KDCQELASISVGSGSRPSSDLQARLG---EL 1091
            E  P  K +L+ ++   K  ++   ++P K+     +     G    +  +A+ G   E 
Sbjct: 351  EETPAAKALLQAKASG-KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED 409

Query: 1092 AGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSG 1146
            +  S E  + + + P  +KP  K  QV     P +E  RK         P RK+G
Sbjct: 410  SQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA----PAPPRKTG 460



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 34/139 (24%), Positives = 58/139 (41%), Gaps = 29/139 (20%)

Query: 223 DITREVRG------RRPERNYQHSRSRSPHSSQSRNQSPQRLASQ------------ASR 264
           D+T +V+G      +R ++  + S S S   S+S  ++P    SQ            AS 
Sbjct: 247 DVTPQVKGGALPPAKRAKKPEEESES-SEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305

Query: 265 PTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDS--------PARSVQSAAVP 316
           P +   G G+           +S + +    + S SSS++S         A+++  A   
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365

Query: 317 APTSQL--LSSLEKDEPRK 333
             TSQ+   S+  K+ PRK
Sbjct: 366 GKTSQVGAASAPAKESPRK 384


>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
            sapiens]
          Length = 1782

 Score = 87.8 bits (216), Expect = 2e-16
 Identities = 251/1273 (19%), Positives = 421/1273 (33%), Gaps = 182/1273 (14%)

Query: 1331 LNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKS 1390
            LNS++E    +  +  + G+ D      + KRDS ++ + +      V  D  +DG+ ++
Sbjct: 94   LNSQEE----EEVIVTEVGQRD---SEDVSKRDSDKEMATKSA----VVHDITDDGQEET 142

Query: 1391 HSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTITPDTKALLER 1450
                       S L  L +  E +  +   +        KF +   DKT  PDT  LL  
Sbjct: 143  PEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKF-TVKKDKTEKPDTVQLLTV 201

Query: 1451 AKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDD 1510
             K             D  S  A    +K+ E   S  +P  +   ++         +   
Sbjct: 202  KKDEGEGAAGAGDHKD-PSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQ 260

Query: 1511 KKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGAN 1570
              E+ KEE +E+QE                                      K+ S+ A 
Sbjct: 261  AVEECKEEGEEKQE--------------------------------------KEPSKSAE 282

Query: 1571 STTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSE 1630
            S T  +         +F        ++K   +KPKE E +   +   + PE     +D +
Sbjct: 283  SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGK 342

Query: 1631 LKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPA 1690
             +        S      E A SA E     +  +  L +EE+       SEE     +PA
Sbjct: 343  AEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEE-----KPA 397

Query: 1691 PAPVEQL-EQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNV 1749
            P   E   E++++      ++  A +     E  + +Q   ++    T G+  ++    +
Sbjct: 398  PLATEVFDEKIEV----HQEEVVAEVHVSTVEERTEEQKTEVE---ETAGSVPAEELVEM 450

Query: 1750 DPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDP 1809
            D EP   +P  +  +  E       E P   AD  PD          S+PP     EV+ 
Sbjct: 451  DAEPQEAEPAKELVKLKETC--VSGEDPTQGADLSPDEKVL------SKPPEGVVSEVEM 502

Query: 1810 PVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELK 1869
              + +  K   S   K         +  K    K    D E  + +  P        E K
Sbjct: 503  LSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQK 562

Query: 1870 MEAEKITRTASKNSAADLEHPEP----SLPLSRTRRRNVRSVYATMGDHENRSPV----- 1920
             E          +SA+  E PE        L+  ++       AT    + R  V     
Sbjct: 563  GE----------SSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWAS 612

Query: 1921 -------KEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAE 1973
                   K+ V +P  + K  E +  ++A + +T       +   +   EE  + +EP  
Sbjct: 613  FKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEP-KPEEPKR 671

Query: 1974 TLKPPEGW-----------RSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIG 2022
             +     W           R+ R   +   GGP+   G ++   +A + +   E G   G
Sbjct: 672  KVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDK---ETGTD-G 727

Query: 2023 VKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRN 2082
            +   S E    +  +  EQ      AG+       +  E  ++   P K SKSK      
Sbjct: 728  ILAGSQEHDPGQGSSSPEQ------AGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSE 781

Query: 2083 SRLA------------VDKSASLKNVDAAV------SPRGAAAQAGERESGVVAVSPEKS 2124
              +A              K  S  ++   +       P G   QA   ++G    + + S
Sbjct: 782  DSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDS 841

Query: 2125 ESPQKEDGLSSQLKSDPVDPDK-EPEKEDVSASGPSPE-ATQLAKQMELEQAVEHIAKLA 2182
            + P     +    + D V+ +K E ++   SA  P  + AT+++K++   Q     A +A
Sbjct: 842  DVP----AVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVA 897

Query: 2183 EASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSII-NDISGEPENFPAPPPYPG 2241
            + + +A    +           +P  Q  E E A     ++  ++  E E      P P 
Sbjct: 898  DGTRAATIIEERSPSWISASVTEPLEQV-EAEAALLTEEVLEREVIAEEEPPTVTEPLPE 956

Query: 2242 E---------SQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPS 2292
                      S+ +L P A   A      G E     S   ET     +     ++PD +
Sbjct: 957  NREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTT 1016

Query: 2293 AGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPV 2352
               T  +E  G   +      + + ++EV   +  K K   +   +       + V+ PV
Sbjct: 1017 EEATPVQEVEGGVPDIEE---QERRTQEVLQAVAEKVKEESQLPGT----GGPEDVLQPV 1069

Query: 2353 ESHVPESNQAQGESPAANEGTTVQHPEAPQEEK-----QSEKPHSTPPQSCTSDLSKIPS 2407
            +    E  + Q E+    + T V      QE K     Q +    T P+S      K P 
Sbjct: 1070 QRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPES----FEKAPQ 1125

Query: 2408 TENS--SQEISVEERTPTKASVPPD-------LPPPPQPAPVDEEPQARFRVHSIIESDP 2458
               S  S E+    +  T A V          +PP     P D E      V       P
Sbjct: 1126 VTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADF--DAP 1183

Query: 2459 VTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPAL 2518
             T   D  + I     V +   S    +  +P Q            QEE + QS     L
Sbjct: 1184 GTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTL 1243

Query: 2519 PPDTKASDVDTSS 2531
                K   V+T S
Sbjct: 1244 EHTDKEVSVETVS 1256



 Score = 82.0 bits (201), Expect = 1e-14
 Identities = 238/1237 (19%), Positives = 437/1237 (35%), Gaps = 263/1237 (21%)

Query: 1618 KTPESAPENKDSELKTPPSVGPPSV----------TVVTLESAPSALEKTTGDKTVEAPL 1667
            ++PE  PE   +  +  PS G PS            +   + A   L+K     T+    
Sbjct: 10   RSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNGQLSTINGVA 69

Query: 1668 VTEEKTVEPATVSEE-----------AKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMP 1716
              +E +++   ++ +           ++   E     V Q +  D+    D DKE A   
Sbjct: 70   EQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSK-RDSDKEMATKS 128

Query: 1717 AGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQK----------- 1765
            A V + +   Q      + P        +ESN++   + TQP    A             
Sbjct: 129  AVVHDITDDGQ-----EETPEIIEQIPSSESNLE---ELTQPTESQANDIGFKKVFKFVG 180

Query: 1766 -SEEANEPKAEKPDAT--ADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSK 1822
                  + K EKPD       + D  + A  A + + P+    E     A+K+ +P +S 
Sbjct: 181  FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGE----AASKESEPKQS- 235

Query: 1823 RSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEA-QKLLELKMEAEKITRTASK 1881
                          EKP     E + RE+     SP  E+ Q + E K E E+       
Sbjct: 236  -------------TEKP----EETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPS 278

Query: 1882 NSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEA 1941
             SA     P  S   S  ++   +           R P ++ VE    + K+ E+E ++ 
Sbjct: 279  KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVE---ASEKKKEQEPEKV 335

Query: 1942 AAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPP------EGWRSPRSQKTAAGGGP 1995
                 T   G+      +    E+   +EPAE+   P      E    P  ++ +   GP
Sbjct: 336  ----DTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGP 391

Query: 1996 QGKKGKN------EPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAG 2049
              +K         + K++  + E   EV      + +  +    EE AGS    +  +  
Sbjct: 392  SEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVE-- 449

Query: 2050 TDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSP------- 2102
             D  P E  P + + K    ++   S    ++ + L+ D+    K  +  VS        
Sbjct: 450  MDAEPQEAEPAKELVKL---KETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQ 506

Query: 2103 -----RGAAAQAGERESGVVAVSPEKSESPQ----KEDGLSSQLKSDPVDPDKEPEKEDV 2153
                 +G+  +     +G+  +S +K +  +    +E G  +Q+ +D  D  +E + E  
Sbjct: 507  ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 566

Query: 2154 SASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAP-EGLAP-----------E 2201
            ++S   PE         LE+ +  + +  EA   A    +   EG+ P           +
Sbjct: 567  ASSPEEPEEITC-----LEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKK 621

Query: 2202 DRDKPAHQASETEL----AAAIGSIINDISGEPENF--PAPPPYPGESQTDLQPPAGAQA 2255
               +P+    E EL    +A + S  +  S   E        P P E +  +      +A
Sbjct: 622  RVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEA 681

Query: 2256 L------------------------------QPSEEGMETDEAVSGIL---ETEAATESS 2282
            L                              +  E G + +    GIL   +     + S
Sbjct: 682  LICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGS 741

Query: 2283 RPPVNAPDPSAGP------------TDTKEARGNSSETS----------HSVPEAK-GSK 2319
              P  A  P+ G             T  K+++    E S          HS P+ + G +
Sbjct: 742  SSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKE 801

Query: 2320 EVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPE-SNQAQGESPAA---NEGTTV 2375
            E  V++ +   GR      R+KR   K+  APVE   P  +N+   + PA    +E   V
Sbjct: 802  ESWVSIKKFIPGR------RKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAV 855

Query: 2376 QHP--EAPQEEKQSEKPHSTPPQSCTSDLSK-------IPSTENSSQEISVEERTPT--K 2424
            +    EA Q +K +E+P        + +LS+           + +     +EER+P+   
Sbjct: 856  EREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWIS 915

Query: 2425 ASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSI--PIP------------ 2470
            ASV   L           E +A      ++E + +     P++  P+P            
Sbjct: 916  ASVTEPLE--------QVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVS 967

Query: 2471 ----TLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITR----QEEPRAQSTPSPALPPDT 2522
                T  +VTAA+ + P+ +      S   + TE ++      + P      +P    + 
Sbjct: 968  EAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEG 1027

Query: 2523 KASDVDTSSSTLRKIL--MDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKK 2580
               D++      +++L  +  K    + +  T     + +PV  A           ++++
Sbjct: 1028 GVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRA-----------EAER 1076

Query: 2581 PLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKIT------SVISRMPVSIDLENS 2634
            P E+  A  +   +++    + V A + K  P    K+       S      V+  +E+S
Sbjct: 1077 PEEQAEASGLKKETDV---VLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESS 1133

Query: 2635 QKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGP 2671
            + +T  +   +TL G+ S    +V    +P ++++ P
Sbjct: 1134 ELVTTCQ--AETLAGVKS--QEMVMEQAIPPDSVETP 1166



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 360/1872 (19%), Positives = 659/1872 (35%), Gaps = 299/1872 (15%)

Query: 685  NDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGASPSQA 744
            N   E+++      QR+ E       S RD D E   +    + VH         +P   
Sbjct: 95   NSQEEEEVIVTEVGQRDSEDV-----SKRDSDKE---MATKSAVVHDITDDGQEETPEII 146

Query: 745  ERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYT-KNEKTDKERTFDPERVE 803
            E++PS SE  L   +       + +    ++K+ K    ++T K +KT+K  T       
Sbjct: 147  EQIPS-SESNLEELTQPTESQANDIG---FKKVFKFVGFKFTVKKDKTEKPDT------- 195

Query: 804  RERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSET-DQENEREQSPEKPRSCNKLSREKA 862
                 ++   V+KD+ +     G    PS  + E   +E+E +QS EKP    K  +  A
Sbjct: 196  -----VQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHA 250

Query: 863  DKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQT 922
            +    A++   +  C      KE+  +  +  P +  ++     T ++ +  +K      
Sbjct: 251  EISPPAESGQAVEEC------KEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGW 304

Query: 923  EPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLE 982
               +   S       + PKE      VE  EK+   K ++  K +   DG + V  EKL 
Sbjct: 305  AGWRKKTS------FRKPKE----DEVEASEKK---KEQEPEKVDTEEDGKAEVASEKLT 351

Query: 983  ARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQPDVSSREVILLREGEAERKP--V 1040
            A ++        A  Q+P      P +        ++ ++ S E +   +G +E KP  +
Sbjct: 352  ASEQ--------AHPQEPAESAHEPRLS----AEYEKVELPSEEQVSGSQGPSEEKPAPL 399

Query: 1041 RKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVENQE 1100
              E+     +KI++ +   VA          + V +    + + +  + E AG SV  +E
Sbjct: 400  ATEVF---DEKIEVHQEEVVAE---------VHVSTVEERTEEQKTEVEETAG-SVPAEE 446

Query: 1101 VQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIG 1160
            +      P + +           P +E V+     +  E P + +       V ++   G
Sbjct: 447  LVEMDAEPQEAE-----------PAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEG 495

Query: 1161 I--DIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDV 1218
            +  +++   S  +   Q    +++       +  G  +K     +R     E G+  Q V
Sbjct: 496  VVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKG----KRGGGDEESGEHTQ-V 550

Query: 1219 TDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSPSVRH-GSFHEDEDPIG 1277
              DSP S++++          K E +  S  +  E +    G   V+  G   E     G
Sbjct: 551  PADSPDSQEEQ----------KGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDG 600

Query: 1278 SPRLLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDEL 1337
              +   V       + V P   +    ES K +  D  +   ++   +   S +  E + 
Sbjct: 601  EKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSS-TESTASEMQEEMKG 659

Query: 1338 NRWDSQMKQDAGRFDVSFP-NSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRAS 1396
            +  + + ++   + D S    ++I   S +KR+ R        S SDE+G  K+      
Sbjct: 660  SVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRG-------SSSDEEGGPKAMGGDHQ 712

Query: 1397 ALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTITPDTK----ALLERAK 1452
               E+ +         DK    D  L+ S E +     +  +     T+    +  E  K
Sbjct: 713  KADEAGK---------DKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFK 763

Query: 1453 SLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKK 1512
             L + R+++ S L+  S  +   +  +    D+ P    SW   KK I    + + D K+
Sbjct: 764  RLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQ 823

Query: 1513 EDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANST 1572
            E    E+                                                GAN  
Sbjct: 824  EQAPVED--------------------------------------------AGPTGANE- 838

Query: 1573 TDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELK 1632
             D    P V+  S +  + R + + ++  +  ++ E++  TE      +   E++   + 
Sbjct: 839  -DDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATE----VSKELSESQVHMMA 893

Query: 1633 TPPSVGPPSVTVVTLESAPSALEKTTGDK----TVEAPLVTEEKTVEPATVSEEAKPASE 1688
               + G  + T++  E +PS +  +  +       EA L+TEE         EE    +E
Sbjct: 894  AAVADGTRAATIIE-ERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTE 952

Query: 1689 PAPAPVEQ-----LEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFS 1743
            P P   E      + + +L P A    E A  P G EEG+        +A          
Sbjct: 953  PLPENREARGDTVVSEAELTPEAVTAAETA-GPLGAEEGT--------EASAAEETTEMV 1003

Query: 1744 QAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPAS- 1802
             A S +   PD+T+  + P Q+ E       E+   T +      +K +   ESQ P + 
Sbjct: 1004 SAVSQLTDSPDTTEE-ATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVK--EESQLPGTG 1060

Query: 1803 --EDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRG 1860
              ED+ + P   A+ ++P +   +    +   V +       K+E   + K+    +P  
Sbjct: 1061 GPEDV-LQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPES 1119

Query: 1861 -EAQKLLELKMEAEKITRTASKNSAADLEHP----EPSLPLSRTRRRNVRSVYATMGDHE 1915
             E    +   +E+ ++  T    + A ++      E ++P              T  + +
Sbjct: 1120 FEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVET-------PTDSETD 1172

Query: 1916 NRSPVKEPVEQPRVTRK------RLEREL--------QEAAAVPTTPRRGRPPKTRRRAD 1961
              +PV +  + P  T+K        E E+         EA AVP   ++ RPP       
Sbjct: 1173 GSTPVAD-FDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPA--QKERPPAPSSFVF 1229

Query: 1962 EEEENEAKEPAETLKPPEGWRS-------PRSQKTAAGGGPQGKKGKNEPKVDATRPEAT 2014
            +EE  E  +  +TL+  +   S        +++ T        +K K+ P  +    E +
Sbjct: 1230 QEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGL--EGS 1287

Query: 2015 TEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTD-----KNPPETAP----VEVVEK 2065
             + G  I V    +   A + E G+E+   +KD   +     K+PP        V+V  +
Sbjct: 1288 IDTG--ITVSREKVTEVALKGE-GTEEAECKKDDALELQSHAKSPPSPVEREMVVQVERE 1344

Query: 2066 KPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSE 2125
            K   E    ++      + + V +  S + +     P       G +E   +  SP    
Sbjct: 1345 KTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVP----IIDGAKEVSSLEGSPPPCL 1400

Query: 2126 SPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEAS 2185
              ++      Q++S           E+    G +  A  L     LE A  H+    ++S
Sbjct: 1401 GQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGET--ANILETGETLEPAGAHLVLEEKSS 1458

Query: 2186 -ASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGE------------PEN 2232
              +  + A   E   P   D  A        A     + +D+ GE             E 
Sbjct: 1459 EKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQ 1518

Query: 2233 FPAPPPYPGESQTDLQPPAGAQALQPS-------------EEGMETDEAVSGILETEAAT 2279
                      +  DL+P  G   L+               ++ + T+E  + +L +E  T
Sbjct: 1519 VACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQT 1578

Query: 2280 ESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSR 2339
            ++    + A    AG    KE     +      P     +E E T V    G+  +  S+
Sbjct: 1579 QAH--VIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAV----GQAHSDISK 1632

Query: 2340 RKRNTNKKVVAPVESHVPESNQAQGES---PAANEGTTVQHPEAPQEE------KQSEKP 2390
                 ++K +  VE      N  Q E    P+  EG        P+++      ++ EK 
Sbjct: 1633 DMSEASEKTMT-VEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1691

Query: 2391 HSTPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRV 2450
               P +    D    P  +NS+   +      TK S   + P   +     E      +V
Sbjct: 1692 LVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKV 1751

Query: 2451 HSIIESDPVTPP 2462
            HS  ESD    P
Sbjct: 1752 HS--ESDKAITP 1761



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 310/1681 (18%), Positives = 607/1681 (36%), Gaps = 292/1681 (17%)

Query: 703  ERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDR 762
            E   +  E  +  +     ++R QS   +  P   G +  + +    + + +  S+S++ 
Sbjct: 224  EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAES 283

Query: 763  SGS-CSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDK 821
              S  +S +   ++K        + K     K +  + E  E+      K++ E +K D 
Sbjct: 284  PTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEK------KKEQEPEKVDT 337

Query: 822  QKR-KGKVHSPSSQSSETDQENEREQSPEKPR---SCNKLSREKADKEGIAKNRLELMPC 877
            ++  K +V S    +SE     E  +S  +PR      K+     ++   ++   E  P 
Sbjct: 338  EEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPA 397

Query: 878  VVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQT--------------- 922
             + T V +++ +V      E++ A++   TV+    +QK +V +T               
Sbjct: 398  PLATEVFDEKIEVHQ----EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAE 453

Query: 923  ----EPAK------------------SDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKA 960
                EPAK                  +DLS  E V  K P+  G+ S VE++  + R+K 
Sbjct: 454  PQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPE--GVVSEVEMLSSQERMKV 511

Query: 961  R-KHLKPEQPADGVSAVDLEKLEARK-----------RRFADSNLKAEKQKPEVKKSSPE 1008
            +   LK    + G+  +  +K + ++           +  ADS    E+QK E   SSPE
Sbjct: 512  QGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPE 571

Query: 1009 M-EDARVLSKKQPDVSS---REVILLREGEAERKPVRK--EILKRESKKIKLDRLNTVAS 1062
              E+   L K   +V      E     +GE +R+ V       K  + K ++ R +    
Sbjct: 572  EPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDK 631

Query: 1063 PKDCQELASISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQ 1122
              +  ++ S ++ S    +S++Q    E+ G   E +  + K+ + +    + L  +   
Sbjct: 632  EDELDKVKSATLSSTESTASEMQE---EMKGSVEEPKPEEPKRKVDTSVSWEALICV--- 685

Query: 1123 GPEREDVRKNYCSLRDETPERKSGQ-EKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQ 1181
            G  ++  R+   S  +  P+   G  +K+     +++ G D     S      Q     +
Sbjct: 686  GSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPE 745

Query: 1182 MEMEIAKSEKFGS----------PKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMD 1231
                  + E   +           KK   + E +S     G   +  T D+ P K++   
Sbjct: 746  QAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWV 805

Query: 1232 HVDFDICTKRERNYRSSRQIS--EDSERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPK 1289
             +   I  +R++     ++ +  ED+  TG +         ED+  + +           
Sbjct: 806  SIKKFIPGRRKKRPDGKQEQAPVEDAGPTGAN---------EDDSDVPA----------- 845

Query: 1290 VDEKVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAG 1349
                V+P S             YD+  RE+M      K    ++E    +  +++ ++  
Sbjct: 846  ----VVPLSE------------YDAVEREKMEAQQAQK----SAEQPEQKAATEVSKELS 885

Query: 1350 RFDVSFPNSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLR 1409
               V    + +   +     + +  P  + +   E        P      E++ L+  + 
Sbjct: 886  ESQVHMMAAAVADGTRAATIIEERSPSWISASVTE--------PLEQVEAEAALLTEEVL 937

Query: 1410 DREDKLRERDERLSSSLERNKFY---SFALDKTITPDTKALLERAKSL-------SSSRE 1459
            +RE    E    ++  L  N+     +   +  +TP+     E A  L       +S+ E
Sbjct: 938  EREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAE 997

Query: 1460 ENWSFLDWDSRFANFRNNKDKEK-VDSAPRPIPSWYMKKK-----------KIRTDSE-- 1505
            E    +   S+  +  +  ++   V      +P    +++           K++ +S+  
Sbjct: 998  ETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLP 1057

Query: 1506 --GKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGK 1563
              G  +D  +  +  E ER E  A     S + ++    L+   ++ +   F  G++ G+
Sbjct: 1058 GTGGPEDVLQPVQRAEAERPEEQAEA---SGLKKETDVVLKVDAQEAKTEPFTQGKVVGQ 1114

Query: 1564 QTSEG---ANSTTDSIQ--EPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPK 1618
             T E    A   T+SI+  E V    +  +   + Q+   E+   P  VE   D+E    
Sbjct: 1115 TTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGS 1174

Query: 1619 TPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPAT 1678
            TP +       +   P +     +  +  E+  ++  ++ G    EA  V  +K   PA 
Sbjct: 1175 TPVA-------DFDAPGTTQKDEIVEIHEENEVASGTQSGG---TEAEAVPAQKERPPAP 1224

Query: 1679 VSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTP 1738
             S   +  ++      + LE  D        KE ++    +   + G Q     A   T 
Sbjct: 1225 SSFVFQEETKEQSKMEDTLEHTD--------KEVSVETVSILSKTEGTQEADQYADEKTK 1276

Query: 1739 GASFSQA-ESNVDPEPD-STQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPE 1796
               F +  E ++D     S + +++ A K E   E + +K DA    E  ++ K+  +P 
Sbjct: 1277 DVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL---ELQSHAKSPPSPV 1333

Query: 1797 SQPPA----SEDLEVDPPVAAKDKKPNKS------KRSKTPVQAAAVSIVE--------- 1837
             +        E  E +P    ++K  +++      + SK  +Q   V I++         
Sbjct: 1334 EREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLE 1393

Query: 1838 --KPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASK--NSAADLEHPEPS 1893
               P     E     K++  +S   EA   L    E EK+    +    +   LE     
Sbjct: 1394 GSPPPCLGQEEAVCTKIQVQSS---EASFTLTAAAEEEKVLGETANILETGETLEPAGAH 1450

Query: 1894 LPLSRTRRRNVRSVYATMGDHE-----NRSPVKEPVEQPRVTRKRLERELQEAAAVPTTP 1948
            L L            A  G+       +      PV     T+K L  +L+         
Sbjct: 1451 LVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGE------- 1503

Query: 1949 RRGRPPKTRRRADEEEENEAKEPA------ETLKPPEGWRSPRSQKTAAGGGPQGKKGKN 2002
               +    + ++DE +E  A +        E L+P  G     ++ +        K  +N
Sbjct: 1504 ---KTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSS--------KLVQN 1552

Query: 2003 EPKVDATRPEATTEVGPQIGVKESSMEP---KAAEEEAGSEQKRDRKD--AGTDKNPPET 2057
              +    +   T E   ++   E   +    KA  ++AG E +++ ++  A      P T
Sbjct: 1553 IIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPIT 1612

Query: 2058 APVEVVEKKPAPEKNSKSKRGRSRNSR--LAVDKSASLKN---VDAAVSPR-----GAAA 2107
            +  E  E     + +S   +  S  S   + V+   S  N   ++  V P      GA  
Sbjct: 1613 SAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGT 1672

Query: 2108 QAGERESG--VVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPE-------------KED 2152
            ++   + G  ++A   EKS    KED      K D VD  +                KE 
Sbjct: 1673 KSVPEDDGHALLAERIEKSLVEPKEDE-----KGDDVDDPENQNSALADTDASGGLTKES 1727

Query: 2153 VSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASE 2212
               +GP  +  + A+++EL++   H      + +  A    A E L  ++R+    + +E
Sbjct: 1728 PDTNGPKQKEKEDAQEVELQEGKVH------SESDKAITPQAQEELQKQERESAKSELTE 1781

Query: 2213 T 2213
            +
Sbjct: 1782 S 1782


>gi|169205253 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 3859

 Score = 87.0 bits (214), Expect = 3e-16
 Identities = 277/1205 (22%), Positives = 403/1205 (33%), Gaps = 143/1205 (11%)

Query: 2390 PHSTPPQSCT-SDLSKIPSTENSSQEISVEER----TPTKASVPPDLPPPPQPAPVDEEP 2444
            P  +P  S T +D   +P T   S  + V        P  ++  P +P  P   P+    
Sbjct: 602  PADSPVLSVTLADSPAVPVTPADSPVVPVTPADGPVVPVASADSPFVPVTPADDPIVSVT 661

Query: 2445 QARFRVHSIIESD-PVTPPSDPSIPIPTLPSVTAAKLSPPVASGGIP--HQSPPTKVTEW 2501
             A      + ++D PV P +    P+  +P  TA     PV + G P    +P       
Sbjct: 662  PAESPAIPVTQADSPVVPVTSADRPV--IPVTTADGRIVPVTAAGDPIVPVTPADTPGSP 719

Query: 2502 ITRQEEP-----RAQSTPSPALPPDTKASDVDTSSSTLRKILM-DPKYVSATSVTS--TS 2553
            +T  + P      A S   P  PPD     V ++   +  +   D   V  TS       
Sbjct: 720  VTSADGPVVPVTSADSPFVPVTPPDGPVVPVTSADGPVAPVSSADGPVVPVTSADGPVAP 779

Query: 2554 VTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAP---PVTNNSEIQASEVLVAADKEKV 2610
            V++A    V   P     P  PV S         P   PV   +      V V       
Sbjct: 780  VSSADGPVVPVTPADTNGPAVPVTSADSPFVPVIPADSPVVPVTPADDPIVPVTPADSSF 839

Query: 2611 APVIA---PKITSVISRMPVSIDLENSQKITLAKP---------APQTLTGLVSALTGLV 2658
             PVI+   P +  + +  PV +D      +    P         A +T+  L  A + ++
Sbjct: 840  VPVISADSPFVPVIPADGPVVVDSSTDVLVVPVFPVNCILVPAFADETVVPLNPADSPVI 899

Query: 2659 NVS-----LVPVNALKGPVKGSVTTLKSLV------STPAGPVNVLKGPVNVLT---GPV 2704
             V+     +VPV     PV   VT+    V       +PA PV    GPV   T    P+
Sbjct: 900  PVTPPDDLVVPVTPTDCPV-APVTSADCPVVPVTPADSPADPVTAADGPVVPFTPADDPI 958

Query: 2705 NVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAG 2764
             V  TP ++ V +V  A G V   ASA +            V+       A    VT A 
Sbjct: 959  -VPVTPADSPVVSVTPADGPVVPVASADSPFVPVTPADDPIVSVTPAESPAIP--VTQAD 1015

Query: 2765 AVIAPSTKCKQRAS--ANENSRFHPGSM---PVIDDRPADAGSGAGLRVNTSEGVVLLSY 2819
            + + P T   +  S     + R  P +    P++   PAD     G  V +++G V+   
Sbjct: 1016 SPVVPVTSADRPVSPVTTADGRIVPVTAAGDPIVPVTPADT---PGSPVTSADGPVVPVT 1072

Query: 2820 SGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPP------SKGPQA 2873
            S      P  ++     + P ++ D      VS +      VT++  P      + GP  
Sbjct: 1073 SADSPFVP--VTPPDGPVVPVTSADGPVAP-VSSADGPVVPVTSADGPVAPVSSADGPVV 1129

Query: 2874 PAGYANV----ATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTV 2929
            P   A+      T +   +   T   SPV+S   AD P +         +  P   G  V
Sbjct: 1130 PVTPADSPFIPVTTADDPIVPVTPADSPVLSVTLADSPVVPVTPADSPVIPVPPANGPVV 1189

Query: 2930 KVLTQGINTPPVLVHNQLVLTPS-----IVTTNKKLADPVTLKIETKVLQPANLGSTLTP 2984
             V +      PV+  + LV+  S     +V  +      V    +  V+      S + P
Sbjct: 1190 PVSSADSPFVPVIPADGLVVLDSSTDVLVVPVSPTDGILVPDLADDPVVSVTIADSPVIP 1249

Query: 2985 HHPPALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSS 3044
              P   P  +P      P  P  PAD  V  +             GP       A  P  
Sbjct: 1250 VTPADSPV-VPVTSADSPVVPVTPADSPVILVTPVGPVVSVTTADGP-VVLVSTADSPVI 1307

Query: 3045 TASTALSTNATVMLAAGIPVP------QFISSIHPEQSVIMPPHSITQTVSLSHLSQGEV 3098
              ++A S    V  A G  VP       F+     +  ++    + +  VS++      +
Sbjct: 1308 PVTSADSPVVPVTPADGPVVPVTSADSPFVPVTPADDPIVPVTPADSPIVSVTPAESPAI 1367

Query: 3099 RMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRA------PQRASTPQPAPAGVPALAS 3152
                P  P+ +  +   +  SP  PL      V        P    TP   P G P  ++
Sbjct: 1368 ----PVTPADSPVVPVTSADSPLIPLTTAGSRVVPVTPTGDPIVPVTPADTP-GSPVTSA 1422

Query: 3153 QHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRA 3212
              P         P+   T        V  ++  + P T P    + V P    V     A
Sbjct: 1423 DGPVVPVTPAGDPIVPVTPADTPGSPVTSADGPVVPVTTPDGPLVPVSPPDGPVVPVTSA 1482

Query: 3213 ADGVVKVPPASKAPQQPGKEAAK-----TPDAKAAPTPTPAPVPVPVPLPAPAPAPH--- 3264
               VV V PA  +P  P   A       TP        TPA +PV    PA  P  H   
Sbjct: 1483 DGPVVPVTPAD-SPFIPVTTADDPIVPVTPADSPVVPVTPADIPVVPVTPANGPVIHVTS 1541

Query: 3265 GEARILTVTPSNQLQGLP-----LTPPVVVTHGVQIVHSSGELFQEYRYGD--IRTYHP- 3316
             +   + V P++ L  L      L  PV  T GV +   + +        D  +    P 
Sbjct: 1542 ADCPFVPVIPADGLVALDSSTDVLVVPVSPTDGVLVPDLADDPVVSVTIADSPVIPVTPA 1601

Query: 3317 -----PAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPA----- 3366
                 P  L        +SV +P    T A GP     P+    PV S  PA  +     
Sbjct: 1602 DSTVVPVTLADGPVVPVTSVDIPVVPVTPANGPVAPVTPVD--DPVVSVNPADGSVVPVT 1659

Query: 3367 -------PPCPPSQLGQPGQPPSSKMPQVSQEAKGTQ--TGVEQPRLPAGPANRPPEPHT 3417
                   P  P   L  P  P  S +  V+         T  + P +P  PA+ P  P T
Sbjct: 1660 SADCPVVPVTPADGLVVPVTPADSPIVPVTPADSPVVLVTSADSPVIPVTPADSPVVPVT 1719

Query: 3418 QVQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTS--GPSTP----PGL 3471
                    +  TS   PV      D   SLP    P     VP TS  GP  P     G 
Sbjct: 1720 SADTDSPGSPVTSADGPVVPVTSAD---SLPVPVTPADGPVVPVTSADGPVAPVSSADGP 1776

Query: 3472 VLPHT 3476
            V+P T
Sbjct: 1777 VVPVT 1781



 Score = 79.7 bits (195), Expect = 5e-14
 Identities = 287/1278 (22%), Positives = 420/1278 (32%), Gaps = 280/1278 (21%)

Query: 2399 TSDLSKIPSTENSSQEISVEER----TPTKASVPPDLPPPPQPAPVDEEPQARFRVHSII 2454
            T+D   IP T   S  + V        P  ++  P +P  P   P+     A   + S+ 
Sbjct: 1301 TADSPVIPVTSADSPVVPVTPADGPVVPVTSADSPFVPVTPADDPIVPVTPADSPIVSVT 1360

Query: 2455 ESD----PVTPPSDPSIPI-----PTLPSVTAAKLSPPVASGGIP--HQSPPTKVTEWIT 2503
             ++    PVTP   P +P+     P +P  TA     PV   G P    +P       +T
Sbjct: 1361 PAESPAIPVTPADSPVVPVTSADSPLIPLTTAGSRVVPVTPTGDPIVPVTPADTPGSPVT 1420

Query: 2504 RQEEPRAQSTPS-----PALPPDTKASDVDTSSSTLRKILM-----------DPKYVSAT 2547
              + P    TP+     P  P DT  S V ++   +  +             D   V  T
Sbjct: 1421 SADGPVVPVTPAGDPIVPVTPADTPGSPVTSADGPVVPVTTPDGPLVPVSPPDGPVVPVT 1480

Query: 2548 SVTSTSVTTAIAE----PVSAA--PCLHEAPPP-PVDSKKPLEEKTAPPVTNNSEIQ--- 2597
            S     V    A+    PV+ A  P +   P   PV    P +    P    N  +    
Sbjct: 1481 SADGPVVPVTPADSPFIPVTTADDPIVPVTPADSPVVPVTPADIPVVPVTPANGPVIHVT 1540

Query: 2598 ----------ASEVLVAADKEK------VAPVIAPKITSVISRMPVSIDLENSQKITLAK 2641
                       ++ LVA D         V+P     +  +     VS+ + +S  I +  
Sbjct: 1541 SADCPFVPVIPADGLVALDSSTDVLVVPVSPTDGVLVPDLADDPVVSVTIADSPVIPVT- 1599

Query: 2642 PAPQTLT------GLVSALTGLVNVSLVPVNALKGPVK----------------GSVTTL 2679
            PA  T+       G V  +T  V++ +VPV    GPV                 GSV  +
Sbjct: 1600 PADSTVVPVTLADGPVVPVTS-VDIPVVPVTPANGPVAPVTPVDDPVVSVNPADGSVVPV 1658

Query: 2680 KSLVS--TPAGPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTV---NAAASAVNA 2734
             S      P  P + L  PV     P+ V  TP ++ V  V +A   V     A S V  
Sbjct: 1659 TSADCPVVPVTPADGLVVPVTPADSPI-VPVTPADSPVVLVTSADSPVIPVTPADSPVVP 1717

Query: 2735 TASAVTVTAGA-VTAASGGVTATTGT----------------VTMAGAVIAP-------- 2769
              SA T + G+ VT+A G V   T                  VT A   +AP        
Sbjct: 1718 VTSADTDSPGSPVTSADGPVVPVTSADSLPVPVTPADGPVVPVTSADGPVAPVSSADGPV 1777

Query: 2770 -------STKCKQRASANENSRFHPGSMPVIDDRPAD-------AGSGAGLRVNTSEGVV 2815
                   S       + +      P   PV+   PA+       +     + V  ++G+V
Sbjct: 1778 VPVTPADSPVVPVTTADDPTVPVTPADSPVVPVPPANGPIVPVTSADSPFVPVIPADGLV 1837

Query: 2816 LLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKP----DSVTASQPPSKGP 2871
            +L  S      P  +S     + P  A D     +++ S V P    DS      P+ GP
Sbjct: 1838 VLDSSTDVLVVP--VSPTDGILVPDLADDPVVSVTIADSPVIPVTPADSPVVLVTPADGP 1895

Query: 2872 QAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKV 2931
              P                 T   +PV+    AD P +    P+   V  PVT      V
Sbjct: 1896 VVPV----------------TSVDNPVVPVTPADNPVIPVT-PVDDPV-VPVTPADDPIV 1937

Query: 2932 LTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHP---- 2987
                 ++P V V           T       PVT   ++ V+  A+  S L P  P    
Sbjct: 1938 PVTSADSPIVSV-----------TPADSPVFPVT-PADSPVIPVASADSPLVPVTPADMV 1985

Query: 2988 --PALPSK---LPTEVNHVPSGPSIPADRTVSHLAAAK-----LDAHSPR-PSGPGPSSF 3036
              P +P+    +P      P+ P  P D  V  + +A      + A SP  P  P  S  
Sbjct: 1986 VVPVIPADGPVIPVTPAESPAIPVTPTDSPVVPVTSADSPVIPVTADSPFVPVTPADSPV 2045

Query: 3037 PRASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQG 3096
               + P          +  V+    +  P  + S+ P  S + P       V     +  
Sbjct: 2046 IPVTPPDDLVVPVTPIDCPVVPVTLVDCP--VVSVTPANSPVDPVTPADGPVVPVTPADS 2103

Query: 3097 EVRMNTPT---------LPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQ-PAPAG 3146
             V   TP            S+  S+ P    SP  P+ P    V +   A +P  P    
Sbjct: 2104 PVIPVTPADDLIVPVTPADSLIVSVTPA--DSPVVPVTPADSPVISVASADSPVVPVTPA 2161

Query: 3147 VPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAV 3206
               +    P +  V   +PV  A +P    + V  ++  + P T   D  + V P  + +
Sbjct: 2162 DTVVVPVTPADGPV---IPVTPAESPA---IPVTPADSPVVPVTPADDPVVPVTPADSPI 2215

Query: 3207 SEQPRAADGVVKVPPASKAPQQPGKEA------AKTPDAKAAP-TPTPAPVPVPVPLPAP 3259
               P A+D VV V PA   P  P   A        + D+   P TP  +PV    P  +P
Sbjct: 2216 VPVPPASDPVVPVTPAD-TPGSPVASADGPVVPVTSADSPLVPVTPGDSPVVPVTPADSP 2274

Query: 3260 A-------------------------------PAPHGEARILTVTPSNQLQGLPLTPPVV 3288
                                            P    ++ ++ VTP+N    +P+ P   
Sbjct: 2275 VFPVTSADGPVFPVTLADDPVFPVTPADDPIFPVSPADSPVVPVTPAN----IPVVPVPP 2330

Query: 3289 VTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKT-AAQGPPPE 3347
                V  V S+G  F                      PA   V L S T        P +
Sbjct: 2331 ANGSVVPVTSAGSPFVPI------------------IPADGLVVLDSSTDVLVVLVSPTD 2372

Query: 3348 GEPL----QPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPR 3403
            G P+      P    +T  +   P  P      P  P    +  V        T V+ P 
Sbjct: 2373 GIPVPDLADDPVVSVTTSDSPVIPVTPTDSPVVPVAPADGPVVPV--------TSVDSPV 2424

Query: 3404 LPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKP-DLPVSLPTQTAPKQPLFVPTT 3462
            +P  PA+ P  P T          P   P    VS+ P D PV +P  TA    + V + 
Sbjct: 2425 VPVTPADSPVIPVTPADSLVVPATPADDP---VVSVTPADGPV-VPVTTADIPVISVTSA 2480

Query: 3463 SGPSTP----PGLVLPHT 3476
              P  P     GLV+P T
Sbjct: 2481 DSPVVPVTPADGLVVPVT 2498



 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 251/1136 (22%), Positives = 372/1136 (32%), Gaps = 164/1136 (14%)

Query: 2422 PTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESD----PVTPPSDPSIPI-----PTL 2472
            P  ++  P +P  P  +PV     A   V  +  +D    PVTP   P  P+     P  
Sbjct: 130  PVTSANGPVIPVTPADSPVFPVASADGPVVPVTPADSPVFPVTPADSPLFPVTPADSPLF 189

Query: 2473 PSVTAAKLSPPV--ASGGIPHQSPPTKVTEWITRQEEP--RAQSTPSPALPPDTKASD-- 2526
            P   A   + PV  A G + H +P       +T  + P     ST SP +P  T A D  
Sbjct: 190  PVTPADSAAIPVTPADGPVVHVTPANGTVVPVTPADSPVVTVASTDSPVVPV-TPADDPI 248

Query: 2527 ---VDTSSSTLRKILMDPKYVSATS----VTSTSVTTAIAEPVSAAPCLHE--------- 2570
                   SS +  I  D  +V        V   S T  +  PV    C+           
Sbjct: 249  VPVTPADSSFVPVISADSPFVPVIPADGPVVVDSSTDVLVVPVFPVNCILVPAFADETIX 308

Query: 2571 -------------------APPPPVDS---KKPLEEKTAPPVTNNSEIQASEVLVAADKE 2608
                                P  P DS      L +    PVT         +       
Sbjct: 309  XXXXXXSLVVSVTTADDPIVPVTPADSPVLSVTLADSPVVPVTPADSPFVPAIPADGPVV 368

Query: 2609 KVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVS-----LV 2663
             V P  +P +    +  PV              PA   +  +  A + +V V+     L+
Sbjct: 369  PVTPADSPVVPVTPADGPVVSVASADSPFVPVTPADDPIVSVTPADSPVVPVTSADSPLI 428

Query: 2664 PVNALKGPV-----KGSVTTLKSLVSTPAGPVNVLKGPVNVLTG---PVNVLTTPVNATV 2715
            PV    G V      G      +   TP  PV    GPV  +T    P+ V  TP +  V
Sbjct: 429  PVTTADGRVVPVTAAGDPIVPVTPADTPGSPVTSADGPVVPVTSADIPL-VPVTPPDGPV 487

Query: 2716 GTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPSTKCKQ 2775
              V +A G V   A   +A    V VT     A S  +  TT    +     A S     
Sbjct: 488  VPVTSADGPV---APVSSADGPVVPVT----PADSPFIPVTTADDLIVPVTPADSPVLSV 540

Query: 2776 RASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKIS 2835
              + +      P   P++   PA+ G    +    S  V ++   G         S  + 
Sbjct: 541  TPAESPAIPVTPADSPIVPVTPAN-GPVVPVTSADSPFVPVIPADGPVVPVTPADSPVVP 599

Query: 2836 QIPPAS-AMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYN 2894
              P  S  + +    S +      DS      P+ GP  P   A+            T  
Sbjct: 600  VTPADSPVLSVTLADSPAVPVTPADSPVVPVTPADGPVVPVASADSP------FVPVTPA 653

Query: 2895 ASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIV 2954
              P++S   A+ P++            PVTQ  +  V     + P +            V
Sbjct: 654  DDPIVSVTPAESPAI------------PVTQADSPVVPVTSADRPVI-----------PV 690

Query: 2955 TTNKKLADPVTLKIETKV-LQPANL-GSTLTPHHPPALP---SKLPTEVNHVPSGPSIP- 3008
            TT      PVT   +  V + PA+  GS +T    P +P   +  P      P GP +P 
Sbjct: 691  TTADGRIVPVTAAGDPIVPVTPADTPGSPVTSADGPVVPVTSADSPFVPVTPPDGPVVPV 750

Query: 3009 --ADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTN--ATVMLAAGIPV 3064
              AD  V+ +++A      P  S  GP +   ++       T   TN  A  + +A  P 
Sbjct: 751  TSADGPVAPVSSAD-GPVVPVTSADGPVAPVSSADGPVVPVTPADTNGPAVPVTSADSPF 809

Query: 3065 PQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLP------SITYSIRPEALH 3118
               I +  P   V      I             +  ++P +P       +      + L 
Sbjct: 810  VPVIPADSPVVPVTPADDPIVPVTPADSSFVPVISADSPFVPVIPADGPVVVDSSTDVLV 869

Query: 3119 SPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSE-- 3176
             P  P+    +   A +      PA + V  +    PP++ V    P     APV S   
Sbjct: 870  VPVFPVNCILVPAFADETVVPLNPADSPVIPVT---PPDDLVVPVTPTDCPVAPVTSADC 926

Query: 3177 --VLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAA 3234
              V V  ++    P T      +   P    +     A   VV V PA   P  P   A 
Sbjct: 927  PVVPVTPADSPADPVTAADGPVVPFTPADDPIVPVTPADSPVVSVTPAD-GPVVPVASA- 984

Query: 3235 KTPDAKAAP-TPTPAPVPVPVPLPAPA-PAPHGEARILTVTPSNQLQGLPLTPPVVVTHG 3292
               D+   P TP   P+    P  +PA P    ++ ++ VT +++    P++P       
Sbjct: 985  ---DSPFVPVTPADDPIVSVTPAESPAIPVTQADSPVVPVTSADR----PVSPVTTADGR 1037

Query: 3293 VQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQ 3352
            +  V ++G+        D     P + +T    P    V + S         PP+G    
Sbjct: 1038 IVPVTAAGDPIVPVTPADT----PGSPVTSADGPV---VPVTSADSPFVPVTPPDG---- 1086

Query: 3353 PPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRP 3412
            P  PV S       P  P S    P  P +S    V+       +  + P +P  PA+ P
Sbjct: 1087 PVVPVTSAD----GPVAPVSSADGPVVPVTSADGPVA-----PVSSADGPVVPVTPADSP 1137

Query: 3413 PEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTP 3468
              P T          P    SPV      D PV +P   A    + VP  +GP  P
Sbjct: 1138 FIPVTTADDPIVPVTPAD--SPVLSVTLADSPV-VPVTPADSPVIPVPPANGPVVP 1190



 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 218/972 (22%), Positives = 313/972 (32%), Gaps = 135/972 (13%)

Query: 2348 VVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPS 2407
            VV PV   +P        +PA +    V   ++P     S     +P    T+D   +P 
Sbjct: 1985 VVVPV---IPADGPVIPVTPAESPAIPVTPTDSPVVPVTSA---DSPVIPVTADSPFVPV 2038

Query: 2408 TENSSQEISVEERTPTKASVPPD---LPPPPQPAPVDEEPQARFRVHSIIES----DPVT 2460
            T   S  I V          PPD   +P  P   PV         V S+  +    DPVT
Sbjct: 2039 TPADSPVIPV---------TPPDDLVVPVTPIDCPVVPVTLVDCPVVSVTPANSPVDPVT 2089

Query: 2461 PPSDPSIPI-----PTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPS 2515
            P   P +P+     P +P   A  L  PV     P  S    VT          A S   
Sbjct: 2090 PADGPVVPVTPADSPVIPVTPADDLIVPVT----PADSLIVSVTP---------ADSPVV 2136

Query: 2516 PALPPDTKASDVDTSSSTLRKIL-MDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPP 2574
            P  P D+    V ++ S +  +   D   V  T      +    AE  +      ++P  
Sbjct: 2137 PVTPADSPVISVASADSPVVPVTPADTVVVPVTPADGPVIPVTPAESPAIPVTPADSPVV 2196

Query: 2575 PVDSKKPLEEKTAPPVTNNSEI----QASEVLVAADKEKVAPVIAPKITSVISRMPVSID 2630
            PV    P ++   P    +S I     AS+ +V      V P   P      +  PV   
Sbjct: 2197 PV---TPADDPVVPVTPADSPIVPVPPASDPVV-----PVTPADTPGSPVASADGPVVPV 2248

Query: 2631 LENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPV 2690
                  +    P    +  +  A     +  + PV +  GPV     TL      P  P 
Sbjct: 2249 TSADSPLVPVTPGDSPVVPVTPA-----DSPVFPVTSADGPV--FPVTLADDPVFPVTPA 2301

Query: 2691 NVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAAS 2750
            +    PV+    PV V  TP N  V  V  A G+V    SA +     +      V  +S
Sbjct: 2302 DDPIFPVSPADSPV-VPVTPANIPVVPVPPANGSVVPVTSAGSPFVPIIPADGLVVLDSS 2360

Query: 2751 GGVTATTGTVTMAGAV--IAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRV 2808
              V     + T    V  +A         S +      P   PV+   PAD   G  + V
Sbjct: 2361 TDVLVVLVSPTDGIPVPDLADDPVVSVTTSDSPVIPVTPTDSPVVPVAPAD---GPVVPV 2417

Query: 2809 NTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPS 2868
             + +  V+             ++   S + P +  D     S+       D    S  P+
Sbjct: 2418 TSVDSPVV------------PVTPADSPVIPVTPAD-----SLVVPATPADDPVVSVTPA 2460

Query: 2869 KGPQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGT 2928
             GP  P   A++   S       T   SPV+    AD   L  P     SV  P T    
Sbjct: 2461 DGPVVPVTTADIPVISV------TSADSPVVPVTPAD--GLVVPVTSADSVVVPATPADC 2512

Query: 2929 VKVLTQGINTPPVLV--HNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHH 2986
              V     ++P VL   ++  V++   VT++     PVT   ++ V+     G  + P  
Sbjct: 2513 PLVPVDPADSPIVLFTPYDNPVVS---VTSDDSPVFPVT-PADSSVVPVTPAGVPVVPVT 2568

Query: 2987 P---------PALPSKLPTEVNHVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFP 3037
            P         PA    +P      P  P  PAD  V  ++ A        P  PG S   
Sbjct: 2569 PGDGPVVPVTPADSLVVPVTSADSPVFPVTPADSPVFPVSPAD---DLVVPVTPGDSPVV 2625

Query: 3038 RASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGE 3097
              S   S        +  V     +PV      + P  S   P   +     L  L    
Sbjct: 2626 PVSPADSPVVLVTPADGPV-----VPVTPANGPVVPVTSADSPFVPVIPADGLVVLDSST 2680

Query: 3098 VRMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPE 3157
              +  P  P+    + P+    P  P+ P       P    TP   P  +P   +   P 
Sbjct: 2681 DVLVVPVFPTDGILV-PDLADDPVVPVTPGD----DPVVPVTPGDDPV-IPVTPADDGP- 2733

Query: 3158 EEVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHP-HVTAVSEQPRAADGV 3216
                  +PV  A  PV  ++    S   + P ++  D  I V P     V +  R +DG 
Sbjct: 2734 -----FVPVTPAVGPVVPDLTADDS---VVPDSLTDDPVISVCPDDGLVVPDTVRDSDG- 2784

Query: 3217 VKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSN 3276
               P  S  P           D      P    + V  P P   PA H       V P  
Sbjct: 2785 ---PEVSVYPVTGPVVTDSAADCPVVSVPLTDGLVVLCP-PDEVPAVHDSVTNGLVVPDP 2840

Query: 3277 QLQGLPLTPPVV 3288
             + G   + P V
Sbjct: 2841 VIDGPVFSNPSV 2852



 Score = 49.3 bits (116), Expect = 7e-05
 Identities = 227/1104 (20%), Positives = 354/1104 (32%), Gaps = 210/1104 (19%)

Query: 2410 NSSQEISVEERTPTKASVPPDLPPPPQ-PAPVDEEPQARFRVHSIIESDPVTPPSDPSIP 2468
            +SS ++ V    PT   + PDL   P  P    ++P             PVTP  DP IP
Sbjct: 2677 DSSTDVLVVPVFPTDGILVPDLADDPVVPVTPGDDPVV-----------PVTPGDDPVIP 2725

Query: 2469 IPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVD 2528
            +          ++P V        +  + V + +T  ++P     P   L       D D
Sbjct: 2726 VTPADDGPFVPVTPAVGPVVPDLTADDSVVPDSLT--DDPVISVCPDDGLVVPDTVRDSD 2783

Query: 2529 TSSSTLRKILMDPKYVSATS--VTSTSVTTAIAE--PVSAAPCLHEA-------PPPPVD 2577
                ++  +       SA    V S  +T  +    P    P +H++       P P +D
Sbjct: 2784 GPEVSVYPVTGPVVTDSAADCPVVSVPLTDGLVVLCPPDEVPAVHDSVTNGLVVPDPVID 2843

Query: 2578 SKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKI 2637
                       PV +N  +    V VA+          P +   I   PV         +
Sbjct: 2844 G----------PVFSNPSVDGPIVPVASADN-------PGVPDPIRAFPVVPKPSTFSPV 2886

Query: 2638 TLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPV 2697
              + PA       +  +    + + VPVN + GPV   ++    +V  P     V+  P 
Sbjct: 2887 VTSTPADW-----IDVIVTPADCADVPVNPVNGPVVPDLSGDCPVVPVPPTDDIVVLNPP 2941

Query: 2698 NVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATT 2757
            +V+     V++TPV  T G V   P T         A  S   VT       +  VT   
Sbjct: 2942 DVVFA---VVSTPV--TDGPVVTDPATDGLMVPVTPANGSVAPVTLSEYPDVT--VTPAD 2994

Query: 2758 GTV---TMAGAVIA-PSTKCKQRASANENSRFHPGSM---PVIDDRPADA-------GSG 2803
            GTV   T+ G V+  PS      ++   +    P  +   PV+   P D           
Sbjct: 2995 GTVVSPTIGGPVVPDPSADSSVVSNPTTDGLIVPNPLLAGPVVPVTPTDGPLAPVILADC 3054

Query: 2804 AGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTA 2863
              + V  ++G V+ +++   T GP      +   P A  + +        S    D    
Sbjct: 3055 PDVTVTPADGPVVCAFT---TGGP------VFPDPTAEGLVV--------SNPTVDDPVV 3097

Query: 2864 SQPPSKG--PQAPAGYANVATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVST 2921
            + P +KG     PA  A+V                PVI +        + P+ +   V+ 
Sbjct: 3098 TNPSTKGLVSATPADCADV----------------PVIPA--------DCPDVLVNLVND 3133

Query: 2922 PVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGST 2981
             V    T       ++ P  LV       P        +  P+T       L    L  +
Sbjct: 3134 SVVPDFTADWTVVSVSPPDDLV------APDPPDEVPVVLVPITDGPVVPDLTTDGLVVS 3187

Query: 2982 LTPHHPPALPSKLP--TEVNHVPS-GPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPR 3038
            +TP   P +P  L    +V   P+  P +P   +   + A  LD     P  P   S   
Sbjct: 3188 VTPAGAPVVPVFLTDCPDVTVTPADSPVVPDPSSDGPVVADSLDDDGLVPVTPADDSVV- 3246

Query: 3039 ASHPSSTASTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEV 3098
               P S A+  +           +P P     + P+ SV  P   +T             
Sbjct: 3247 ---PDSPANGLV-----------VPDPTTDGPVAPDPSVDGPVVPVTPA----------- 3281

Query: 3099 RMNTPTLPSITYSIRPEALHSPRAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEE 3158
              + PT+ S+T +  P+   +P     P  + V   +R     P   G+           
Sbjct: 3282 --DAPTV-SVTLADCPDVTVTP-----PDGLVVSDSKRGG---PVVTGLST--------- 3321

Query: 3159 EVHYHLPVARATAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVK 3218
                + PV  AT    S+V V  +++   P T      + V+P    VS+       V  
Sbjct: 3322 ----NDPVITATPADFSDVTVTPADFEDVPVTPANCPDVPVNPESPVVSDLAVDFLVVPV 3377

Query: 3219 VPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQL 3278
            VP       +P  +    PD    P      V  P+     A  P  +  ++ V+P++  
Sbjct: 3378 VPSDDLVVLEPPDKVPVVPD----PISNGLVVSDPITNNTAATDPSVDGSVVPVSPADG- 3432

Query: 3279 QGLPLT----PPVVVTHGVQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLP 3334
               P+T    P V +T     V S  ++  E+    +                       
Sbjct: 3433 PVAPVTLADCPDVTITPADDSVVSDSKIRAEFEDVPV----------------------- 3469

Query: 3335 SRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKG 3394
                T A  P     P   P            P  PP  L  P   P  ++P V      
Sbjct: 3470 ----TIADCPNVPVNPKSGPVVSDLAVDCPVVPIPPPDDLVAP--EPPDEVPVVPDPI-- 3521

Query: 3395 TQTGVEQPRLPAGPANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPK 3454
            T + V    +  GP    P     V    + +G     S   VS+ PD    +P      
Sbjct: 3522 TDSLVVSDPMTDGPVASDPSIDGIVVPVVSPSGLLVLDSVADVSILPDTSADVPVTPVTL 3581

Query: 3455 QPLFVPTTSGPSTPPGLVLPHTEF 3478
                V   S P  P   VLP   F
Sbjct: 3582 ADGSVVPDSAPDCPVVPVLPTDGF 3605



 Score = 40.0 bits (92), Expect = 0.043
 Identities = 151/705 (21%), Positives = 221/705 (31%), Gaps = 120/705 (17%)

Query: 2421 TPTKASVPPDL--PPPPQPAPVDEEPQARFRVHSIIESD----PVTPPSDPSIPI--PTL 2472
            T    S P DL  P PP   PV   P     V   + +D     VTP   P +P+     
Sbjct: 3144 TVVSVSPPDDLVAPDPPDEVPVVLVPITDGPVVPDLTTDGLVVSVTPAGAPVVPVFLTDC 3203

Query: 2473 PSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSSS 2532
            P VT      PV    +P  S    V           A S     L P T A D     S
Sbjct: 3204 PDVTVTPADSPV----VPDPSSDGPVV----------ADSLDDDGLVPVTPADDSVVPDS 3249

Query: 2533 TLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPLEEKTAPPVTN 2592
                ++                   + +P +  P    AP P VD           PVT 
Sbjct: 3250 PANGLV-------------------VPDPTTDGPV---APDPSVDGP-------VVPVTP 3280

Query: 2593 NSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVS 2652
                  S  L       V P     ++      PV   L  +  +  A PA  +   +  
Sbjct: 3281 ADAPTVSVTLADCPDVTVTPPDGLVVSDSKRGGPVVTGLSTNDPVITATPADFSDVTVTP 3340

Query: 2653 ALTGLVNVSLVPVNALKGPVKGSVTTLKSL-VSTPAGPVNVLKGPVNVLTGPVNVLTTPV 2711
            A     +V + P N    PV      +  L V     PV V    + VL  P  V   P 
Sbjct: 3341 A--DFEDVPVTPANCPDVPVNPESPVVSDLAVDFLVVPV-VPSDDLVVLEPPDKVPVVPD 3397

Query: 2712 NATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTVTMAGAVIAPST 2771
              + G V + P T N AA+  +   S V V+      A G V      VT+A       T
Sbjct: 3398 PISNGLVVSDPITNNTAATDPSVDGSVVPVSP-----ADGPVAP----VTLADCPDVTIT 3448

Query: 2772 KCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRIS 2831
                   ++   R         +D P        + VN   G V+   +         + 
Sbjct: 3449 PADDSVVSDSKIRAE------FEDVPVTIADCPNVPVNPKSGPVVSDLA---------VD 3493

Query: 2832 AKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQ 2891
              +  IPP                  PD + A +PP + P  P    +  T S +V    
Sbjct: 3494 CPVVPIPP------------------PDDLVAPEPPDEVPVVP----DPITDSLVVSDPM 3531

Query: 2892 TYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLV--- 2948
            T    PV S    D   +    P  L V   V     +   +  +   PV + +  V   
Sbjct: 3532 T--DGPVASDPSIDGIVVPVVSPSGLLVLDSVADVSILPDTSADVPVTPVTLADGSVVPD 3589

Query: 2949 ------LTPSIVTTNKKLADPVTLKIETKVLQPANLGSTL---TPHHPPALPSKLPTEVN 2999
                  + P + T    + D   L     V  PA++G  +   T   P ++    P   +
Sbjct: 3590 SAPDCPVVPVLPTDGFVVLD--LLVDGVVVPNPADVGPVVPDPTTDGPDSI-KDFPLVPD 3646

Query: 3000 HVPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLA 3059
              P  P +P  RT   +           P  PG  S    +   +     L+T+  V+  
Sbjct: 3647 PWPDCPVVPVTRTDGPVVLDSSADGVVVPVTPGDDSVALVTPTDNLVVPDLTTDGPVVPD 3706

Query: 3060 AGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPT 3104
                 P  + S+  +  V  PP  +  TV  + ++   V ++  T
Sbjct: 3707 PSADGPVVLVSLADDLLVPNPP--VKDTVVPNSVADNPVALDPVT 3749



 Score = 38.9 bits (89), Expect = 0.095
 Identities = 35/128 (27%), Positives = 51/128 (39%), Gaps = 15/128 (11%)

Query: 1637 VGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQ 1696
            V P    V+++ SA S +   T   TV  P+   +  V P T +E       PA +PV  
Sbjct: 2138 VTPADSPVISVASADSPVVPVTPADTVVVPVTPADGPVIPVTPAESPAIPVTPADSPV-- 2195

Query: 1697 LEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPP-----TPGASFSQAESNVDP 1751
               V + P  DP     ++P    +      PP  D   P     TPG+  + A+  V P
Sbjct: 2196 ---VPVTPADDP-----VVPVTPADSPIVPVPPASDPVVPVTPADTPGSPVASADGPVVP 2247

Query: 1752 EPDSTQPL 1759
               +  PL
Sbjct: 2248 VTSADSPL 2255



 Score = 35.4 bits (80), Expect = 1.0
 Identities = 40/194 (20%), Positives = 71/194 (36%), Gaps = 17/194 (8%)

Query: 1617 PKTPESAPENKDSELKTPPSVGP------PSVTVVTLESAPSALEKTTGDKTVEAPLVTE 1670
            P TP   P      +   P+ GP        + V+++ SA S +   T    +  P+ + 
Sbjct: 2446 PATPADDPV-----VSVTPADGPVVPVTTADIPVISVTSADSPVVPVTPADGLVVPVTSA 2500

Query: 1671 EKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGD-QPP 1729
            +  V PAT ++      +PA +P+      D P  +    ++ + P    + S     P 
Sbjct: 2501 DSVVVPATPADCPLVPVDPADSPIVLFTPYDNPVVSVTSDDSPVFPVTPADSSVVPVTPA 2560

Query: 1730 YLDAKPPTPG----ASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEP 1785
             +   P TPG       + A+S V P   +  P+  P   ++    P +   D      P
Sbjct: 2561 GVPVVPVTPGDGPVVPVTPADSLVVPVTSADSPVF-PVTPADSPVFPVSPADDLVVPVTP 2619

Query: 1786 DANQKAEAAPESQP 1799
              +     +P   P
Sbjct: 2620 GDSPVVPVSPADSP 2633



 Score = 35.0 bits (79), Expect = 1.4
 Identities = 53/250 (21%), Positives = 87/250 (34%), Gaps = 20/250 (8%)

Query: 1612 DTENHPKTPESAPENKDSELKTP-PSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTE 1670
            DT   P T    P    +    P   V PP   VV + SA   +   +       P+   
Sbjct: 454  DTPGSPVTSADGPVVPVTSADIPLVPVTPPDGPVVPVTSADGPVAPVSSADGPVVPVTPA 513

Query: 1671 EKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEG-----SSG 1725
            +    P T +++      PA +PV  +   + P       ++ ++P     G     +S 
Sbjct: 514  DSPFIPVTTADDLIVPVTPADSPVLSVTPAESPAIPVTPADSPIVPVTPANGPVVPVTSA 573

Query: 1726 DQP--PYLDAKPPTPGASFSQAESNVDPEPDSTQPL------SKPAQKSEEANEPKAEKP 1777
            D P  P + A  P      + A+S V P   +  P+        PA     A+ P     
Sbjct: 574  DSPFVPVIPADGPV--VPVTPADSPVVPVTPADSPVLSVTLADSPAVPVTPADSPVVPVT 631

Query: 1778 DATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVE 1837
             A     P A+  +   P +  PA + +    P  +      ++     PV +A   ++ 
Sbjct: 632  PADGPVVPVASADSPFVPVT--PADDPIVSVTPAESPAIPVTQADSPVVPVTSADRPVI- 688

Query: 1838 KPVTRKSERI 1847
             PVT    RI
Sbjct: 689  -PVTTADGRI 697



 Score = 34.7 bits (78), Expect = 1.8
 Identities = 43/202 (21%), Positives = 69/202 (34%), Gaps = 10/202 (4%)

Query: 1617 PKTPESAPENKDSELKTPP-SVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVE 1675
            P TP + P    + +  P  SV P   +VV + SA   +   T    +  P+   +  + 
Sbjct: 1627 PVTPANGPVAPVTPVDDPVVSVNPADGSVVPVTSADCPVVPVTPADGLVVPVTPADSPIV 1686

Query: 1676 PATVSEEAKPASEPAPAPVEQLEQVDLP--PGADPDKEAAMMPAGVEEG-----SSGDQP 1728
            P T ++        A +PV  +   D P  P    D ++   P    +G     +S D  
Sbjct: 1687 PVTPADSPVVLVTSADSPVIPVTPADSPVVPVTSADTDSPGSPVTSADGPVVPVTSADSL 1746

Query: 1729 PYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDAN 1788
            P        P    + A+  V P   +  P+  P   ++    P     D T    P A+
Sbjct: 1747 PVPVTPADGPVVPVTSADGPVAPVSSADGPV-VPVTPADSPVVPVTTADDPTVPVTP-AD 1804

Query: 1789 QKAEAAPESQPPASEDLEVDPP 1810
                  P +  P       D P
Sbjct: 1805 SPVVPVPPANGPIVPVTSADSP 1826



 Score = 34.3 bits (77), Expect = 2.3
 Identities = 41/195 (21%), Positives = 68/195 (34%), Gaps = 16/195 (8%)

Query: 1617 PKTPESAPENKDSELKTPP-SVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVE 1675
            P TP  +P +  +    P     P    +V +  A S +   T       P+ + +    
Sbjct: 930  PVTPADSPADPVTAADGPVVPFTPADDPIVPVTPADSPVVSVTPADGPVVPVASADSPFV 989

Query: 1676 PATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEG------SSGDQPP 1729
            P T +++   +  PA +P   + Q D P       +  + P    +G      ++GD  P
Sbjct: 990  PVTPADDPIVSVTPAESPAIPVTQADSPVVPVTSADRPVSPVTTADGRIVPVTAAGD--P 1047

Query: 1730 YLDAKP-PTPGASFSQAESNVDPEPDSTQPL------SKPAQKSEEANEPKAEKPDATAD 1782
             +   P  TPG+  + A+  V P   +  P         P      A+ P A    A   
Sbjct: 1048 IVPVTPADTPGSPVTSADGPVVPVTSADSPFVPVTPPDGPVVPVTSADGPVAPVSSADGP 1107

Query: 1783 AEPDANQKAEAAPES 1797
              P  +     AP S
Sbjct: 1108 VVPVTSADGPVAPVS 1122



 Score = 32.7 bits (73), Expect = 6.8
 Identities = 43/200 (21%), Positives = 67/200 (33%), Gaps = 14/200 (7%)

Query: 1617 PKTPESAP----ENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEK 1672
            P TP   P     + DS          P V+V   ES   A+  T  D  V  P+ + ++
Sbjct: 629  PVTPADGPVVPVASADSPFVPVTPADDPIVSVTPAESP--AIPVTQADSPV-VPVTSADR 685

Query: 1673 TVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLD 1732
             V P T ++        A  P+  +   D P       +  ++P      +S D P    
Sbjct: 686  PVIPVTTADGRIVPVTAAGDPIVPVTPADTPGSPVTSADGPVVPV-----TSADSPFVPV 740

Query: 1733 AKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEP-DANQKA 1791
              P  P    + A+  V P   +  P+  P   ++    P +          P D N  A
Sbjct: 741  TPPDGPVVPVTSADGPVAPVSSADGPV-VPVTSADGPVAPVSSADGPVVPVTPADTNGPA 799

Query: 1792 EAAPESQPPASEDLEVDPPV 1811
                 +  P    +  D PV
Sbjct: 800  VPVTSADSPFVPVIPADSPV 819



 Score = 32.3 bits (72), Expect = 8.9
 Identities = 25/106 (23%), Positives = 45/106 (42%), Gaps = 9/106 (8%)

Query: 1617 PKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEP 1676
            P TP  +P      +   P+ GP    VV + S  S +   T   +   P+   +  V P
Sbjct: 2396 PVTPTDSPV-----VPVAPADGP----VVPVTSVDSPVVPVTPADSPVIPVTPADSLVVP 2446

Query: 1677 ATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEG 1722
            AT +++   +  PA  PV  +   D+P  +    ++ ++P    +G
Sbjct: 2447 ATPADDPVVSVTPADGPVVPVTTADIPVISVTSADSPVVPVTPADG 2492


>gi|239508976 PREDICTED: mucin 12, cell surface associated [Homo
            sapiens]
          Length = 2036

 Score = 87.0 bits (214), Expect = 3e-16
 Identities = 329/1643 (20%), Positives = 538/1643 (32%), Gaps = 239/1643 (14%)

Query: 1620 PESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATV 1679
            PES+  +  SE ++    G  + T  +  S  +AL  T+   ++ +   T  +     + 
Sbjct: 4    PESSTTSGHSE-ESATFHGSTTHTKSSTPSTTAALAHTSYHSSLGSTETTHFRDSSTISG 62

Query: 1680 SEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAA-MMPAGVEEGSSGDQPPYLDAKPPTP 1738
              E   AS  +P   + +    LP G+ P        P+ +  GS   +   L      P
Sbjct: 63   RSEESKASHSSP---DAMATTVLPAGSTPSVLVGDSTPSPISSGSM--ETTALPGSTTKP 117

Query: 1739 GASFSQAESNVDPE-PDSTQ-PLSKPAQKSEEANEPKAEKPDAT-------ADAEPDANQ 1789
            G S         P  PD+T  P S  +    E +     +P +T       +   P  +Q
Sbjct: 118  GLSEKSTTFYSSPRSPDTTHLPASMTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGLSQ 177

Query: 1790 KAEAAPESQPPASEDLE--------VDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPV- 1840
            ++ A+  S  P    L         + P       +P  ++ +  P    A  ++E  + 
Sbjct: 178  ESTASHSSPGPTDTTLSPGSTTASSLGPEYTTFHSRPGSTETTLLPDNTTASGLLEASMP 237

Query: 1841 TRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEP-------S 1893
               S R     L  + S   + +        + K TR A   + +    P         S
Sbjct: 238  VHSSTRSPHTTLSPAGSTTRQGESTTFHSWPSSKDTRPAPPTTTSAFVEPSTTSHGSPSS 297

Query: 1894 LPLSRTRRRNVRSVYATMGDHENRSPVK-EPVEQPRVTRKRLERELQEAAAVPTTPRRGR 1952
            +P +    R+  S         + SP   + +  P         E    +   TT     
Sbjct: 298  IPTTHISARSTTSGLVEESTTYHSSPGSTQTMHFPESDTTSGRGEESTTSHSSTTHTISS 357

Query: 1953 PPKTRRRADEEEENEAKEPAETLK---PPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDAT 2009
             P T     EE  +    P  T     P     S RS+++ A    Q   G       +T
Sbjct: 358  APSTTSALVEEPTSYHSSPGSTATTHFPDSSTTSGRSEESTASHSSQDATGTIVLPARST 417

Query: 2010 RP----EATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDA--GTDKNPPET-APVEV 2062
                  E+TT       +   SME  A      +    +R      + ++P  T +P   
Sbjct: 418  TSVLLGESTTSP-----ISSGSMETTALPGSTTTPGLSERSTTFHSSPRSPATTLSPAST 472

Query: 2063 VEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPE 2122
                 + E  +   R  S ++    D + +       +S     + +    +    +   
Sbjct: 473  TSSGVSEESTTSRSRPGSTHTTAFPDSTTT-----PGLSRHSTTSHSSPGSTDTTLLPAS 527

Query: 2123 KSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLA 2182
             + S   ++  +S   S   D    P      + G      Q +          H     
Sbjct: 528  TTTSGPSQESTTSHSSSGSTDTALSPGSTTALSFG------QESTTFHSNPGSTHTTLFP 581

Query: 2183 EASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGE 2242
            +++ S+        G+        +   S     +   S    + GE   F     +P  
Sbjct: 582  DSTTSS--------GIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQT---HPAS 630

Query: 2243 SQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEAR 2302
            + T   PP+ A A  P EE                +T   R P + P      + T    
Sbjct: 631  THTTPSPPSTATA--PVEE----------------STTYHRSPGSTPTTHFPASSTTSGH 672

Query: 2303 GNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQA 2362
               S   HS P+A G+     +      GR ++T SR    + +    P  +  P  ++A
Sbjct: 673  SEKSTIFHSSPDASGT--TPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEA 730

Query: 2363 QGE------------SPAANEGTTVQHPEAPQEEKQSEKPHST--PPQSCTSDLSKIPST 2408
                           SPA+     V   E+     Q    HST  P  + T  LS+  +T
Sbjct: 731  STTFYSSPRSPTTTLSPASMTSLGVGE-ESTTSRSQPGSTHSTVSPASTTTPGLSEESTT 789

Query: 2409 ENSSQEISVEERT---PTKASVPPDLPPP--PQPAPVDEEPQARFRVHSIIESDPVTPPS 2463
              SS   S E       T  SV  + P     +PA             S +  +    P 
Sbjct: 790  VYSSSRGSTETTVFPHSTTTSVHGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPG 849

Query: 2464 DPSIPIPTLP-SVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDT 2522
             P+     LP ++T A L     +      S  TK++   +       +STPS   P  T
Sbjct: 850  SPASTQTGLPATLTTADLGEESTTFPSSSGSTGTKLSPARSTTSGLVGESTPSRLSPSST 909

Query: 2523 KASDVDTSSST------LRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPV 2576
            + + +  S +T             P+   AT   +T+ ++ ++E  S +   H  P    
Sbjct: 910  ETTTLPGSPTTPSLSEKSTTFYTSPRSPDATLSPATTTSSGVSEESSTS---HSQP---- 962

Query: 2577 DSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENS-- 2634
                       P  T  S++        + +      ++P  T+  S    S    +S  
Sbjct: 963  ---GSTHTTAFPDSTTTSDLSQEPTTSHSSQGSTEATLSPGSTTASSLGQQSTTFHSSPG 1019

Query: 2635 QKITLAKPAPQTLTGLVSA------LTGLVNVSLVPVNALKGPVKGSVTTLKSLVS---T 2685
               T   P     +GLV A       TG ++ +L P ++    ++   TT +S  S   T
Sbjct: 1020 DTETTLLPDDTITSGLVEASTPTHSSTGSLHTTLTPASSTSAGLQEESTTFQSWPSSSDT 1079

Query: 2686 PAGPVNVLKGPVNVLT----GPVNVLTTPVNA---TVG------TVNAAPGTVNAAASAV 2732
               P      PV V T     P +  TT  +A   T+G      TV+++PG   A  +A+
Sbjct: 1080 TPSPPGTTAAPVEVSTTYHSRPSSTPTTHFSASSTTLGRSEESTTVHSSPG---ATGTAL 1136

Query: 2733 NATASAVTVTAGAVTAA--SGGVTATT---GTVTMAGAVIAPSTKCKQRASANENSRFHP 2787
              T SA +V  G  T +  S G T TT   G+ T AG              + +++ F+ 
Sbjct: 1137 FPTRSATSVLVGEPTTSPISSGSTETTALPGSTTTAGL-------------SEKSTTFY- 1182

Query: 2788 GSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEF 2847
             S P   D      S       TS GV   S +     G    S   +  P ++ M    
Sbjct: 1183 -SSPRSPDTTLSPAS------TTSSGVSEESTTSHSRPG----STHTTAFPGSTTMPGVS 1231

Query: 2848 QQSVSK--------SQVKPDSVTASQPPSKGPQAPAGYANVATHSTLVLTAQTYNASPVI 2899
            Q+S +         + + P S TAS   S GP++   +++  +  T +L   T  AS + 
Sbjct: 1232 QESTASHSSPGSTDTTLSPGSTTAS---SLGPESTTFHSSPGSTETTLLPDNT-TASGL- 1286

Query: 2900 SSVKADRPSLEKPEPIHLSVSTPVT----QGGTVKVLTQGINTPPVLVHNQLVLTPSIVT 2955
                     LE   P+H S  +P T     G T +   QG +T      +     P+  T
Sbjct: 1287 ---------LEASTPVHSSTGSPHTTLSPAGSTTR---QGESTTFQSWPSSKDTMPAPPT 1334

Query: 2956 TNKKLADPVTLKIETKVLQP--------ANLG---STLTPHHPPALPSKLPTEVNHVPSG 3004
            T     +  T    +    P          LG    + T H  P   +  P+      SG
Sbjct: 1335 TTSAFVELSTTSHGSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSG 1394

Query: 3005 PSIPADRTVSHLAAAKLDA-HSPRPS-GPGPSSFPRASHPSSTASTALSTNATVMLAAGI 3062
              +  + T  H +       H P  S   G S   R SH SST  T  S  +T       
Sbjct: 1395 --LVEESTAYHSSPGSTQTMHFPESSTASGRSEESRTSH-SSTTHTISSPPSTTSALVEE 1451

Query: 3063 PVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSIT-----YSIRPEAL 3117
            P     +S H     I   H    + +     +     ++P    IT     ++      
Sbjct: 1452 P-----TSYHSSPGSIATTHFPESSTTSGRSEESTASHSSPDTNGITPLPAHFTTSGRIA 1506

Query: 3118 HSPRAPLQPQQIEVRAPQRASTP 3140
             S    + P  +E      A+TP
Sbjct: 1507 ESTTFYISPGSMETTLASTATTP 1529



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 31/101 (30%), Positives = 45/101 (44%), Gaps = 12/101 (11%)

Query: 230 GRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSS 289
           GR  E    HS +    SS     +P   ++    PT   S  GS + +   DS  S++S
Sbjct: 339 GRGEESTTSHSSTTHTISS-----APSTTSALVEEPTSYHSSPGSTATTHFPDS--STTS 391

Query: 290 TSSDSSDSSSSSSDDS-----PARSVQSAAVPAPTSQLLSS 325
             S+ S +S SS D +     PARS  S  +   T+  +SS
Sbjct: 392 GRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISS 432



 Score = 33.9 bits (76), Expect = 3.0
 Identities = 33/116 (28%), Positives = 49/116 (42%), Gaps = 18/116 (15%)

Query: 239 HSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSS 298
           HS  RSP ++ S   +     S+ S        + SRSR  S+ + +   ST++      
Sbjct: 457 HSSPRSPATTLSPASTTSSGVSEES--------TTSRSRPGSTHTTAFPDSTTTPGLSRH 508

Query: 299 SSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDG 354
           S++S  SP  S  +  +PA T+    S E      S G         STDT+L  G
Sbjct: 509 STTSHSSPG-STDTTLLPASTTTSGPSQESTTSHSSSG---------STDTALSPG 554


>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
            sapiens]
          Length = 1684

 Score = 86.7 bits (213), Expect = 4e-16
 Identities = 245/1245 (19%), Positives = 409/1245 (32%), Gaps = 175/1245 (14%)

Query: 1359 IIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRER 1418
            + KRDS ++ + +      V  D  +DG+ ++           S L  L +  E +  + 
Sbjct: 17   VSKRDSDKEMATKSA----VVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDI 72

Query: 1419 DERLSSSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNK 1478
              +        KF +   DKT  PDT  LL   K             D  S  A    +K
Sbjct: 73   GFKKVFKFVGFKF-TVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKD-PSLGAGEAASK 130

Query: 1479 DKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQ 1538
            + E   S  +P  +   ++         +     E+ KEE +E+QE              
Sbjct: 131  ESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQE-------------- 176

Query: 1539 DSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEK 1598
                                    K+ S+ A S T  +         +F        ++K
Sbjct: 177  ------------------------KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKK 212

Query: 1599 EKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTT 1658
               +KPKE E +   +   + PE     +D + +        S      E A SA E   
Sbjct: 213  TSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRL 272

Query: 1659 GDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQL-EQVDLPPGADPDKEAAMMPA 1717
              +  +  L +EE+       SEE     +PAP   E   E++++      ++  A +  
Sbjct: 273  SAEYEKVELPSEEQVSGSQGPSEE-----KPAPLATEVFDEKIEV----HQEEVVAEVHV 323

Query: 1718 GVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKP 1777
               E  + +Q   ++    T G+  ++    +D EP   +P  +  +  E       E P
Sbjct: 324  STVEERTEEQKTEVE---ETAGSVPAEELVEMDAEPQEAEPAKELVKLKETC--VSGEDP 378

Query: 1778 DATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVE 1837
               AD  PD          S+PP     EV+   + +  K   S   K         +  
Sbjct: 379  TQGADLSPDEKVL------SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSG 432

Query: 1838 KPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEP----S 1893
            K    K    D E  + +  P        E K E          +SA+  E PE      
Sbjct: 433  KKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGE----------SSASSPEEPEEITCLE 482

Query: 1894 LPLSRTRRRNVRSVYATMGDHENRSPV------------KEPVEQPRVTRKRLERELQEA 1941
              L+  ++       AT    + R  V            K+ V +P  + K  E +  ++
Sbjct: 483  KGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKS 542

Query: 1942 AAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGW-----------RSPRSQKTA 1990
            A + +T       +   +   EE  + +EP   +     W           R+ R   + 
Sbjct: 543  ATLSSTESTASEMQEEMKGSVEEP-KPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSD 601

Query: 1991 AGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGT 2050
              GGP+   G ++   +A + +   E G   G+   S E    +  +  EQ      AG+
Sbjct: 602  EEGGPKAMGGDHQKADEAGKDK---ETGTD-GILAGSQEHDPGQGSSSPEQ------AGS 651

Query: 2051 DKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLA------------VDKSASLKNVDA 2098
                   +  E  ++   P K SKSK        +A              K  S  ++  
Sbjct: 652  PTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKK 711

Query: 2099 AV------SPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDK-EPEKE 2151
             +       P G   QA   ++G    + + S+ P     +    + D V+ +K E ++ 
Sbjct: 712  FIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVP----AVVPLSEYDAVEREKMEAQQA 767

Query: 2152 DVSASGPSPE-ATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQA 2210
              SA  P  + AT+++K++   Q     A +A+ + +A    +           +P  Q 
Sbjct: 768  QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQV 827

Query: 2211 SETELAAAIGSII-NDISGEPENFPAPPPYPGE---------SQTDLQPPAGAQALQPSE 2260
             E E A     ++  ++  E E      P P           S+ +L P A   A     
Sbjct: 828  -EAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGP 886

Query: 2261 EGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKE 2320
             G E     S   ET     +     ++PD +   T  +E  G   +      + + ++E
Sbjct: 887  LGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEE---QERRTQE 943

Query: 2321 VEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEA 2380
            V   +  K K   +   +       + V+ PV+    E  + Q E+    + T V     
Sbjct: 944  VLQAVAEKVKEESQLPGT----GGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVD 999

Query: 2381 PQEEK-----QSEKPHSTPPQSCTSDLSKIPSTENS--SQEISVEERTPTKASVPPD--- 2430
             QE K     Q +    T P+S      K P    S  S E+    +  T A V      
Sbjct: 1000 AQEAKTEPFTQGKVVGQTTPES----FEKAPQVTESIESSELVTTCQAETLAGVKSQEMV 1055

Query: 2431 ----LPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIPIPTLPSVTAAKLSPPVAS 2486
                +PP     P D E      V       P T   D  + I     V +   S    +
Sbjct: 1056 MEQAIPPDSVETPTDSETDGSTPVADF--DAPGTTQKDEIVEIHEENEVASGTQSGGTEA 1113

Query: 2487 GGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPPDTKASDVDTSS 2531
              +P Q            QEE + QS     L    K   V+T S
Sbjct: 1114 EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVS 1158



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 355/1846 (19%), Positives = 650/1846 (35%), Gaps = 294/1846 (15%)

Query: 711  SDRDRDHERRPIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLS 770
            S RD D E   +    + VH         +P   E++PS SE  L   +       + + 
Sbjct: 18   SKRDSDKE---MATKSAVVHDITDDGQEETPEIIEQIPS-SESNLEELTQPTESQANDIG 73

Query: 771  PPRYEKLDKSRLERYT-KNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVH 829
               ++K+ K    ++T K +KT+K  T            ++   V+KD+ +     G   
Sbjct: 74   ---FKKVFKFVGFKFTVKKDKTEKPDT------------VQLLTVKKDEGEGAAGAGDHK 118

Query: 830  SPSSQSSET-DQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEG 888
             PS  + E   +E+E +QS EKP    K  +  A+    A++   +  C      KE+  
Sbjct: 119  DPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEEC------KEEGE 172

Query: 889  KVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSH 948
            +  +  P +  ++     T ++ +  +K         +   S       + PKE      
Sbjct: 173  EKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTS------FRKPKE----DE 222

Query: 949  VEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPE 1008
            VE  EK+   K ++  K +   DG + V  EKL A ++        A  Q+P      P 
Sbjct: 223  VEASEKK---KEQEPEKVDTEEDGKAEVASEKLTASEQ--------AHPQEPAESAHEPR 271

Query: 1009 MEDARVLSKKQPDVSSREVILLREGEAERKP--VRKEILKRESKKIKLDRLNTVASPKDC 1066
            +        ++ ++ S E +   +G +E KP  +  E+     +KI++ +   VA     
Sbjct: 272  LS----AEYEKVELPSEEQVSGSQGPSEEKPAPLATEVF---DEKIEVHQEEVVAE---- 320

Query: 1067 QELASISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPER 1126
                 + V +    + + +  + E AG SV  +E+      P + +           P +
Sbjct: 321  -----VHVSTVEERTEEQKTEVEETAG-SVPAEELVEMDAEPQEAE-----------PAK 363

Query: 1127 EDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGI--DIDHTQSYRKQMEQSRRKQQMEM 1184
            E V+     +  E P + +       V ++   G+  +++   S  +   Q    +++  
Sbjct: 364  ELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFT 423

Query: 1185 EIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERN 1244
                 +  G  +K     +R     E G+  Q V  DSP S++++          K E +
Sbjct: 424  STGLKKLSGKKQKG----KRGGGDEESGEHTQ-VPADSPDSQEEQ----------KGESS 468

Query: 1245 YRSSRQISEDSERTGGSPSVRH-GSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVR 1303
              S  +  E +    G   V+  G   E     G  +   V       + V P   +   
Sbjct: 469  ASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRP 528

Query: 1304 EESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFP-NSIIKR 1362
             ES K +  D  +   ++   +   S +  E + +  + + ++   + D S    ++I  
Sbjct: 529  SESDKEDELDKVKSATLSS-TESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICV 587

Query: 1363 DSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERL 1422
             S +KR+ R        S SDE+G  K+         E+ +         DK    D  L
Sbjct: 588  GSSKKRARRG-------SSSDEEGGPKAMGGDHQKADEAGK---------DKETGTDGIL 631

Query: 1423 SSSLERNKFYSFALDKTITPDTK----ALLERAKSLSSSREENWSFLDWDSRFANFRNNK 1478
            + S E +     +  +     T+    +  E  K L + R+++ S L+  S  +   +  
Sbjct: 632  AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 691

Query: 1479 DKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQ 1538
            +    D+ P    SW   KK I    + + D K+E    E+                   
Sbjct: 692  EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVED------------------- 732

Query: 1539 DSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEK 1598
                                         GAN   D    P V+  S +  + R + + +
Sbjct: 733  -------------------------AGPTGANE--DDSDVPAVVPLSEYDAVEREKMEAQ 765

Query: 1599 EKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTT 1658
            +  +  ++ E++  TE      +   E++   +    + G  + T++  E +PS +  + 
Sbjct: 766  QAQKSAEQPEQKAATE----VSKELSESQVHMMAAAVADGTRAATIIE-ERSPSWISASV 820

Query: 1659 GDK----TVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQ-----LEQVDLPPGADPD 1709
             +       EA L+TEE         EE    +EP P   E      + + +L P A   
Sbjct: 821  TEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTA 880

Query: 1710 KEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEA 1769
             E A  P G EEG+        +A           A S +   PD+T+  + P Q+ E  
Sbjct: 881  AETA-GPLGAEEGT--------EASAAEETTEMVSAVSQLTDSPDTTEE-ATPVQEVEGG 930

Query: 1770 NEPKAEKPDATADAEPDANQKAEAAPESQPPAS---EDLEVDPPVAAKDKKPNKSKRSKT 1826
                 E+   T +      +K +   ESQ P +   ED+ + P   A+ ++P +   +  
Sbjct: 931  VPDIEEQERRTQEVLQAVAEKVK--EESQLPGTGGPEDV-LQPVQRAEAERPEEQAEASG 987

Query: 1827 PVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRG-EAQKLLELKMEAEKITRTASKNSAA 1885
              +   V +       K+E   + K+    +P   E    +   +E+ ++  T    + A
Sbjct: 988  LKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLA 1047

Query: 1886 DLEHP----EPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRK------RLE 1935
             ++      E ++P              T  + +  +PV +  + P  T+K        E
Sbjct: 1048 GVKSQEMVMEQAIPPDSVET-------PTDSETDGSTPVAD-FDAPGTTQKDEIVEIHEE 1099

Query: 1936 REL--------QEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRS---- 1983
             E+         EA AVP   ++ RPP       +EE  E  +  +TL+  +   S    
Sbjct: 1100 NEVASGTQSGGTEAEAVPA--QKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETV 1157

Query: 1984 ---PRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSE 2040
                +++ T        +K K+ P  +    E + + G  I V    +   A + E G+E
Sbjct: 1158 SILSKTEGTQEADQYADEKTKDVPFFEGL--EGSIDTG--ITVSREKVTEVALKGE-GTE 1212

Query: 2041 QKRDRKDAGTD-----KNPPETAP----VEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSA 2091
            +   +KD   +     K+PP        V+V  +K   E    ++      + + V +  
Sbjct: 1213 EAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEV 1272

Query: 2092 SLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKE 2151
            S + +     P       G +E   +  SP      ++      Q++S           E
Sbjct: 1273 SKQLLQTVNVP----IIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAE 1328

Query: 2152 DVSASGPSPEATQLAKQMELEQAVEHIAKLAEAS-ASAAYKADAPEGLAPEDRDKPAHQA 2210
            +    G +  A  L     LE A  H+    ++S  +  + A   E   P   D  A   
Sbjct: 1329 EEKVLGET--ANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1386

Query: 2211 SETELAAAIGSIINDISGE------------PENFPAPPPYPGESQTDLQPPAGAQALQP 2258
                 A     + +D+ GE             E           +  DL+P  G   L+ 
Sbjct: 1387 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1446

Query: 2259 S-------------EEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNS 2305
                          ++ + T+E  + +L +E  T++    + A    AG    KE     
Sbjct: 1447 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAH--VIKADSQDAGQETEKEGEEPQ 1504

Query: 2306 SETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGE 2365
            +      P     +E E T V    G+  +  S+     ++K +  VE      N  Q E
Sbjct: 1505 ASAQDETPITSAKEESESTAV----GQAHSDISKDMSEASEKTMT-VEVEGSTVNDQQLE 1559

Query: 2366 S---PAANEGTTVQHPEAPQEE------KQSEKPHSTPPQSCTSDLSKIPSTENSSQEIS 2416
                P+  EG        P+++      ++ EK    P +    D    P  +NS+   +
Sbjct: 1560 EVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADT 1619

Query: 2417 VEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPP 2462
                  TK S   + P   +     E      +VHS  ESD    P
Sbjct: 1620 DASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHS--ESDKAITP 1663



 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 310/1681 (18%), Positives = 607/1681 (36%), Gaps = 292/1681 (17%)

Query: 703  ERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDR 762
            E   +  E  +  +     ++R QS   +  P   G +  + +    + + +  S+S++ 
Sbjct: 126  EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAES 185

Query: 763  SGS-CSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDK 821
              S  +S +   ++K        + K     K +  + E  E+      K++ E +K D 
Sbjct: 186  PTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEK------KKEQEPEKVDT 239

Query: 822  QKR-KGKVHSPSSQSSETDQENEREQSPEKPR---SCNKLSREKADKEGIAKNRLELMPC 877
            ++  K +V S    +SE     E  +S  +PR      K+     ++   ++   E  P 
Sbjct: 240  EEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPA 299

Query: 878  VVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQT--------------- 922
             + T V +++ +V      E++ A++   TV+    +QK +V +T               
Sbjct: 300  PLATEVFDEKIEVHQ----EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAE 355

Query: 923  ----EPAK------------------SDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKA 960
                EPAK                  +DLS  E V  K P+  G+ S VE++  + R+K 
Sbjct: 356  PQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPE--GVVSEVEMLSSQERMKV 413

Query: 961  R-KHLKPEQPADGVSAVDLEKLEARK-----------RRFADSNLKAEKQKPEVKKSSPE 1008
            +   LK    + G+  +  +K + ++           +  ADS    E+QK E   SSPE
Sbjct: 414  QGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPE 473

Query: 1009 M-EDARVLSKKQPDVSS---REVILLREGEAERKPVRK--EILKRESKKIKLDRLNTVAS 1062
              E+   L K   +V      E     +GE +R+ V       K  + K ++ R +    
Sbjct: 474  EPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDK 533

Query: 1063 PKDCQELASISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQ 1122
              +  ++ S ++ S    +S++Q    E+ G   E +  + K+ + +    + L  +   
Sbjct: 534  EDELDKVKSATLSSTESTASEMQE---EMKGSVEEPKPEEPKRKVDTSVSWEALICV--- 587

Query: 1123 GPEREDVRKNYCSLRDETPERKSGQ-EKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQ 1181
            G  ++  R+   S  +  P+   G  +K+     +++ G D     S      Q     +
Sbjct: 588  GSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPE 647

Query: 1182 MEMEIAKSEKFGS----------PKKDVDEYERRSLVHEVGKPPQDVTDDSPPSKKKRMD 1231
                  + E   +           KK   + E +S     G   +  T D+ P K++   
Sbjct: 648  QAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWV 707

Query: 1232 HVDFDICTKRERNYRSSRQIS--EDSERTGGSPSVRHGSFHEDEDPIGSPRLLSVKGSPK 1289
             +   I  +R++     ++ +  ED+  TG +         ED+  + +           
Sbjct: 708  SIKKFIPGRRKKRPDGKQEQAPVEDAGPTGAN---------EDDSDVPA----------- 747

Query: 1290 VDEKVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDELNRWDSQMKQDAG 1349
                V+P S             YD+  RE+M      K    ++E    +  +++ ++  
Sbjct: 748  ----VVPLSE------------YDAVEREKMEAQQAQK----SAEQPEQKAATEVSKELS 787

Query: 1350 RFDVSFPNSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRASALYESSRLSFLLR 1409
               V    + +   +     + +  P  + +   E        P      E++ L+  + 
Sbjct: 788  ESQVHMMAAAVADGTRAATIIEERSPSWISASVTE--------PLEQVEAEAALLTEEVL 839

Query: 1410 DREDKLRERDERLSSSLERNKFY---SFALDKTITPDTKALLERAKSL-------SSSRE 1459
            +RE    E    ++  L  N+     +   +  +TP+     E A  L       +S+ E
Sbjct: 840  EREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAE 899

Query: 1460 ENWSFLDWDSRFANFRNNKDKEK-VDSAPRPIPSWYMKKK-----------KIRTDSE-- 1505
            E    +   S+  +  +  ++   V      +P    +++           K++ +S+  
Sbjct: 900  ETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLP 959

Query: 1506 --GKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGK 1563
              G  +D  +  +  E ER E  A     S + ++    L+   ++ +   F  G++ G+
Sbjct: 960  GTGGPEDVLQPVQRAEAERPEEQAEA---SGLKKETDVVLKVDAQEAKTEPFTQGKVVGQ 1016

Query: 1564 QTSEG---ANSTTDSIQ--EPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPK 1618
             T E    A   T+SI+  E V    +  +   + Q+   E+   P  VE   D+E    
Sbjct: 1017 TTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGS 1076

Query: 1619 TPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPAT 1678
            TP +       +   P +     +  +  E+  ++  ++ G    EA  V  +K   PA 
Sbjct: 1077 TPVA-------DFDAPGTTQKDEIVEIHEENEVASGTQSGG---TEAEAVPAQKERPPAP 1126

Query: 1679 VSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTP 1738
             S   +  ++      + LE  D        KE ++    +   + G Q     A   T 
Sbjct: 1127 SSFVFQEETKEQSKMEDTLEHTD--------KEVSVETVSILSKTEGTQEADQYADEKTK 1178

Query: 1739 GASFSQA-ESNVDPEPD-STQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPE 1796
               F +  E ++D     S + +++ A K E   E + +K DA    E  ++ K+  +P 
Sbjct: 1179 DVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL---ELQSHAKSPPSPV 1235

Query: 1797 SQPPA----SEDLEVDPPVAAKDKKPNKS------KRSKTPVQAAAVSIVE--------- 1837
             +        E  E +P    ++K  +++      + SK  +Q   V I++         
Sbjct: 1236 EREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLE 1295

Query: 1838 --KPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASK--NSAADLEHPEPS 1893
               P     E     K++  +S   EA   L    E EK+    +    +   LE     
Sbjct: 1296 GSPPPCLGQEEAVCTKIQVQSS---EASFTLTAAAEEEKVLGETANILETGETLEPAGAH 1352

Query: 1894 LPLSRTRRRNVRSVYATMGDHE-----NRSPVKEPVEQPRVTRKRLERELQEAAAVPTTP 1948
            L L            A  G+       +      PV     T+K L  +L+         
Sbjct: 1353 LVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGE------- 1405

Query: 1949 RRGRPPKTRRRADEEEENEAKEPA------ETLKPPEGWRSPRSQKTAAGGGPQGKKGKN 2002
               +    + ++DE +E  A +        E L+P  G     ++ +        K  +N
Sbjct: 1406 ---KTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSS--------KLVQN 1454

Query: 2003 EPKVDATRPEATTEVGPQIGVKESSMEP---KAAEEEAGSEQKRDRKD--AGTDKNPPET 2057
              +    +   T E   ++   E   +    KA  ++AG E +++ ++  A      P T
Sbjct: 1455 IIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPIT 1514

Query: 2058 APVEVVEKKPAPEKNSKSKRGRSRNSR--LAVDKSASLKN---VDAAVSPR-----GAAA 2107
            +  E  E     + +S   +  S  S   + V+   S  N   ++  V P      GA  
Sbjct: 1515 SAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGT 1574

Query: 2108 QAGERESG--VVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPE-------------KED 2152
            ++   + G  ++A   EKS    KED      K D VD  +                KE 
Sbjct: 1575 KSVPEDDGHALLAERIEKSLVEPKEDE-----KGDDVDDPENQNSALADTDASGGLTKES 1629

Query: 2153 VSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASE 2212
               +GP  +  + A+++EL++   H      + +  A    A E L  ++R+    + +E
Sbjct: 1630 PDTNGPKQKEKEDAQEVELQEGKVH------SESDKAITPQAQEELQKQERESAKSELTE 1683

Query: 2213 T 2213
            +
Sbjct: 1684 S 1684


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.126    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 164,215,725
Number of Sequences: 37866
Number of extensions: 9542079
Number of successful extensions: 121491
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 668
Number of HSP's successfully gapped in prelim test: 2984
Number of HSP's that attempted gapping in prelim test: 48404
Number of HSP's gapped (non-prelim): 48107
length of query: 3664
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3542
effective length of database: 13,627,866
effective search space: 48269901372
effective search space used: 48269901372
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 72 (32.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.