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Search of human proteins with 14670392
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14670392 bromodomain adjacent to zinc finger domain, 1B
[Homo sapiens]
(1483 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14670392 bromodomain adjacent to zinc finger domain, 1B [Homo... 2981 0.0
gi|32967605 bromodomain adjacent to zinc finger domain, 1A isofo... 248 3e-65
gi|32967603 bromodomain adjacent to zinc finger domain, 1A isofo... 235 3e-61
gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo... 142 3e-33
gi|91176325 bromodomain adjacent to zinc finger domain, 2A [Homo... 117 1e-25
gi|148612882 cat eye syndrome chromosome region, candidate 2 [Ho... 81 7e-15
gi|52630326 chromodomain helicase DNA binding protein 3 isoform ... 74 8e-13
gi|52630322 chromodomain helicase DNA binding protein 3 isoform ... 74 8e-13
gi|158420731 chromodomain helicase DNA binding protein 3 isoform... 74 8e-13
gi|226442963 jumonji, AT rich interactive domain 1C isoform 2 [H... 73 2e-12
gi|109255243 jumonji, AT rich interactive domain 1C isoform 1 [H... 73 2e-12
gi|164419758 bromodomain containing 2 [Homo sapiens] 72 4e-12
gi|4826806 bromodomain containing 2 [Homo sapiens] 72 4e-12
gi|24308089 chromodomain helicase DNA binding protein 5 [Homo sa... 71 7e-12
gi|11067749 bromodomain containing protein 3 [Homo sapiens] 69 4e-11
gi|7657218 bromodomain-containing protein 4 isoform short [Homo ... 67 1e-10
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 67 1e-10
gi|40805843 K(lysine) acetyltransferase 2B [Homo sapiens] 67 1e-10
gi|57242796 jumonji, AT rich interactive domain 1B [Homo sapiens] 67 2e-10
gi|169218173 PREDICTED: similar to Jumonji, AT rich interactive ... 67 2e-10
gi|34996489 pleckstrin homology domain interacting protein [Homo... 67 2e-10
gi|38788260 bromodomain PHD finger transcription factor isoform ... 66 2e-10
gi|38788274 bromodomain PHD finger transcription factor isoform ... 66 2e-10
gi|110618244 retinoblastoma binding protein 2 isoform 1 [Homo sa... 66 2e-10
gi|110618242 retinoblastoma binding protein 2 isoform 2 [Homo sa... 66 2e-10
gi|226443002 jumonji, AT rich interactive domain 1D isoform 3 [H... 66 2e-10
gi|33356560 jumonji, AT rich interactive domain 1D isoform 2 [Ho... 66 2e-10
gi|226442991 jumonji, AT rich interactive domain 1D isoform 1 [H... 66 2e-10
gi|51599156 chromodomain helicase DNA binding protein 4 [Homo sa... 65 5e-10
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 65 6e-10
>gi|14670392 bromodomain adjacent to zinc finger domain, 1B [Homo
sapiens]
Length = 1483
Score = 2981 bits (7729), Expect = 0.0
Identities = 1483/1483 (100%), Positives = 1483/1483 (100%)
Query: 1 MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQL 60
MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQL
Sbjct: 1 MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQL 60
Query: 61 THKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEEC 120
THKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEEC
Sbjct: 61 THKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEEC 120
Query: 121 DFEVGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVV 180
DFEVGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVV
Sbjct: 121 DFEVGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVV 180
Query: 181 KEDEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADS 240
KEDEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADS
Sbjct: 181 KEDEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADS 240
Query: 241 LIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMT 300
LIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMT
Sbjct: 241 LIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMT 300
Query: 301 LNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSK 360
LNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSK
Sbjct: 301 LNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSK 360
Query: 361 SPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGRSKGILNGQKSTGN 420
SPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGRSKGILNGQKSTGN
Sbjct: 361 SPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGRSKGILNGQKSTGN 420
Query: 421 SKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIA 480
SKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIA
Sbjct: 421 SKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIA 480
Query: 481 YYKENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSE 540
YYKENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSE
Sbjct: 481 YYKENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSE 540
Query: 541 EQRKEYLKKKREELKKKLKEKAKERREKEMLERLEKQKRYEDQELTGKNLPAFRLVDTPE 600
EQRKEYLKKKREELKKKLKEKAKERREKEMLERLEKQKRYEDQELTGKNLPAFRLVDTPE
Sbjct: 541 EQRKEYLKKKREELKKKLKEKAKERREKEMLERLEKQKRYEDQELTGKNLPAFRLVDTPE 600
Query: 601 GLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQ 660
GLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQ
Sbjct: 601 GLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQ 660
Query: 661 TLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFE 720
TLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFE
Sbjct: 661 TLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFE 720
Query: 721 DNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKER 780
DNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKER
Sbjct: 721 DNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKER 780
Query: 781 LAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMIS 840
LAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMIS
Sbjct: 781 LAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMIS 840
Query: 841 AVKSRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRR 900
AVKSRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRR
Sbjct: 841 AVKSRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRR 900
Query: 901 TPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFNHHCKDHTVSGDEDYCPRSKKAN 960
TPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFNHHCKDHTVSGDEDYCPRSKKAN
Sbjct: 901 TPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFNHHCKDHTVSGDEDYCPRSKKAN 960
Query: 961 LGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKER 1020
LGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKER
Sbjct: 961 LGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKER 1020
Query: 1021 LEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEF 1080
LEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEF
Sbjct: 1021 LEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEF 1080
Query: 1081 EARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMV 1140
EARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMV
Sbjct: 1081 EARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMV 1140
Query: 1141 EEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLI 1200
EEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLI
Sbjct: 1141 EEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLI 1200
Query: 1201 LCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESD 1260
LCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESD
Sbjct: 1201 LCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESD 1260
Query: 1261 EEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAP 1320
EEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAP
Sbjct: 1261 EEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAP 1320
Query: 1321 PVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVI 1380
PVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVI
Sbjct: 1321 PVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVI 1380
Query: 1381 THPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLVALL 1440
THPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLVALL
Sbjct: 1381 THPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLVALL 1440
Query: 1441 HKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEAVGQSRGRRQKK 1483
HKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEAVGQSRGRRQKK
Sbjct: 1441 HKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEAVGQSRGRRQKK 1483
>gi|32967605 bromodomain adjacent to zinc finger domain, 1A isoform b
[Homo sapiens]
Length = 1524
Score = 248 bits (633), Expect = 3e-65
Identities = 262/1009 (25%), Positives = 429/1009 (42%), Gaps = 177/1009 (17%)
Query: 472 PPAALHLIAYYKENKDREDKRSALSCVISKTAR----LLSSEDRARLPEELRSLVQKRYE 527
PP +H+ +D + L+ SK + LL E+ L E L +++ +
Sbjct: 279 PPKRIHI-----SQEDNVANKQTLASYRSKATKERDKLLKQEEMKSLAFEKAKLKREKAD 333
Query: 528 LLEHKKRWASMSEEQRKEYLKKKREEL--KKKLKEKAKERREKEMLERLEKQKRY----- 580
LE KK+ E++R+E K EE KK+ KE+ K REKE + E++++Y
Sbjct: 334 ALEAKKKEKEDKEKKREELKKIVEEERLKKKEEKERLKVEREKEREKLREEKRKYVEYLK 393
Query: 581 ------EDQELTG-KNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYP-- 631
ED E K LP V T LP +FGD MV+EFL+ + L ++P
Sbjct: 394 QWSKPREDMECDDLKELPEPTPVKTR--LPPEIFGDALMVLEFLNAFGELFDLQDEFPDG 451
Query: 632 ITAVSLMEALSA-DKGG------FLYLNRVLVILLQTLLQDEIAE----DYGELGMKLSE 680
+T L EAL D G F +L + + + ++E+A+ D G L
Sbjct: 452 VTLEVLEEALVGNDSEGPLCELLFFFLTAIFQAIAEE--EEEVAKEQLTDADTKGCSLKS 509
Query: 681 IPLTLHSVSELVRLCLRRSDVQEESEGSDTD-------DNKDSAAFEDNEVQDEFLEKLE 733
+ L ++SE++RL + S S + D D A E ++KL
Sbjct: 510 LDLDSCTLSEILRLHILASGADVTSANAKYRYQKRGGFDATDDACMELRLSNPSLVKKLS 569
Query: 734 TSEFFELTSEEKLQILTALCHRILMTYSVQD-----------------------HMETRQ 770
++ ++LT EK++IL ALC ++L S +D H + R+
Sbjct: 570 STSVYDLTPGEKMKILHALCGKLLTLVSTRDFIEDYVDILRQAKQEFRELKAEQHRKERE 629
Query: 771 QMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNK-------ENGKVENGLGKTDRKKE 823
+ +A + K + LKE+ K + +++K KE E +N E + + + E
Sbjct: 630 EAAARIRKRKEEKLKEQEQKMKEKQEKLKEDEQRNSTADISIGEEEREDFDTSIESKDTE 689
Query: 824 IVKFEPQVDTEAEDMISAVKSRRLLAIQAKKEREIQEREMKVKLERQA----EEERIRKH 879
+ + + TE ED + K R +E +E + R+ EEE +++
Sbjct: 690 QKELDQDMVTEDEDDPGSHKRGRRGKRGQNGFKEFTRQEQINCVTREPLTADEEEALKQE 749
Query: 880 KAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEK---GWVHDSIDYR 936
EK E I A P+G DR + RYW+F +PGLFIE+ G D + R
Sbjct: 750 HQRKEKELLEKIQSAIACTNIFPLGRDRMYRRYWIF-PSIPGLFIEEDYSGLTEDMLLPR 808
Query: 937 FNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDS 996
+ +++ S D ++ + + ++ S N G + +V+ P N W S
Sbjct: 809 PSSF-QNNVQSQDPQVSTKTGEPLMSESTS-NIDQG-PRDHSVQLPKPVHKPNRWCFYSS 865
Query: 997 QKELDELLNCLHPQGIRESQLKERLEKRYQDII--------HSIHLARKPNLGLK----- 1043
++LD+L+ L+ +G RES LKE L + I H + KP K
Sbjct: 866 CEQLDQLIEALNSRGHRESALKETLLQEKSRICAQLARFSEEKFHFSDKPQPDSKPTYSR 925
Query: 1044 -----SCDGNQ-----ELLNFLRSDLIEVATRLQKGGLGYVEET------SEFEA---RV 1084
+ D +Q +L LR L+++ R+ +G LG ++ T S E+ +
Sbjct: 926 GRSSNAYDPSQMCAEKQLELRLRDFLLDIEDRIYQGTLGAIKVTDRHIWRSALESGRYEL 985
Query: 1085 ISLEKL---------KDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDE 1135
+S E +D E I Q VI K + K + S +++ + V
Sbjct: 986 LSEENKENGIIKTVNEDVEEMEIDEQTKVIVK--DRLLGIKTETPSTVSTNASTPQSVSS 1043
Query: 1136 ----------------EKKMVEEAKVAS--------ALEKWKTAIREAQTFSRMHVLLGM 1171
E++ ++ AS L++W+ ++ + + S++ + L
Sbjct: 1044 VVHYLAMALFQIEQGIERRFLKAPLDASDSGRSYKTVLDRWRESLLSSASLSQVFLHLST 1103
Query: 1172 LDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPAC 1231
LD + W S NARCK+CRKKG+ + ++LCD C++ H +C+RP L VP+G+W CP C
Sbjct: 1104 LDRSVIWSKSILNARCKICRKKGDAENMVLCDGCDRGHHTYCVRPKLKTVPEGDWFCPEC 1163
Query: 1232 QPATARRNSRGRNYTEESASEDSEDDESDEEEE----EEEEEEEEEDYEV---------- 1277
+P R R + ED ED E++E EEE + EEE+YEV
Sbjct: 1164 RPKQRSRRLSSRQRPSLESDEDVEDSMGGEDDEVDGDEEEGQSEEEEYEVEQDEDDSQEE 1223
Query: 1278 --AGLRLRPRKTI------RGKHSVIPPAARSGRRPGKKPHSTRRSQPK 1318
L R R + RGK S + + PG+ P +++S PK
Sbjct: 1224 EEVSLPKRGRPQVRLPVKTRGKLSSSFSSRGQQQEPGRYPSRSQQSTPK 1272
Score = 60.1 bits (144), Expect = 2e-08
Identities = 30/91 (32%), Positives = 54/91 (59%), Gaps = 2/91 (2%)
Query: 1335 KRSSRRQS--LELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVITHPMDFQTVQNK 1392
+RSS RQ EL E+++ ++V++ SWPF + V++ + DYYD+I P+ ++ K
Sbjct: 1391 RRSSGRQGGVHELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREK 1450
Query: 1393 CSCGSYRSVQEFLTDMKQVFTNAEVYNCRGS 1423
+ Y+ EF+ D++ +F+N YN R +
Sbjct: 1451 VNKCEYKLASEFIDDIELMFSNCFEYNPRNT 1481
Score = 57.0 bits (136), Expect = 1e-07
Identities = 48/188 (25%), Positives = 86/188 (45%), Gaps = 15/188 (7%)
Query: 3 PLLGRKPFPLVKP---LPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQ 59
PLL RKPF KP L +E +F T E FR +++ R + +W+C TG
Sbjct: 2 PLLHRKPFVRQKPPADLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPG 61
Query: 60 LTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVH----HNTASLEKLVDTAWLEIMTKYA 115
LT++EA E E++ + L + FP E L++ +++ + + L ++ D + + +Y
Sbjct: 62 LTYQEALESEKKARQNL-QSFP---EPLIIPVLYLTSLTHRSRLHEICDDIFAYVKDRYF 117
Query: 116 VGEECDFEVGKEKMLKVKIVKIHPLEK----VDEEATEKKSDGACDSPSSDKENSSQIAQ 171
V E + L+ +I+++ P + + S S D E S Q
Sbjct: 118 VEETVEVIRNNGARLQCRILEVLPPSHQNGFANGHVNSVDGETIIISDSDDSETQSCSFQ 177
Query: 172 DHQKKETV 179
+ +KK+ +
Sbjct: 178 NGKKKDAI 185
Score = 39.7 bits (91), Expect = 0.022
Identities = 41/186 (22%), Positives = 74/186 (39%), Gaps = 18/186 (9%)
Query: 313 PDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKM 372
P+ +P ++S+ LSS P L ++ S+ G +V + EE E+ +
Sbjct: 1161 PECRPKQRSRR----LSSRQRPSLESDEDVEDSMGGEDDEVDGDEEEGQSEEEEYEVEQD 1216
Query: 373 MSPNKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGR--SKGILNGQKSTGNSKSPKKGLKT 430
++ +PK+G P + P+K +G+ S GQ+ + T
Sbjct: 1217 EDDSQEEEEVSLPKRGRPQVR------LPVKTRGKLSSSFSSRGQQQEPGRYPSRSQQST 1270
Query: 431 PKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKP--HKHLPPAALHLIAYYKENKDR 488
PKT + T + +K+ AP + R +S+ H H P A + + R
Sbjct: 1271 PKTTVSSKT----GRSLRKINSAPPTETKSLRIASRSTRHSHGPLQADVFVELLSPRRKR 1326
Query: 489 EDKRSA 494
++SA
Sbjct: 1327 RGRKSA 1332
>gi|32967603 bromodomain adjacent to zinc finger domain, 1A isoform a
[Homo sapiens]
Length = 1556
Score = 235 bits (599), Expect = 3e-61
Identities = 264/1042 (25%), Positives = 431/1042 (41%), Gaps = 211/1042 (20%)
Query: 472 PPAALHLIAYYKENKDREDKRSALSCVISKTAR----LLSSEDRARLPEELRSLVQKRYE 527
PP +H+ +D + L+ SK + LL E+ L E L +++ +
Sbjct: 279 PPKRIHI-----SQEDNVANKQTLASYRSKATKERDKLLKQEEMKSLAFEKAKLKREKAD 333
Query: 528 LLEHKKRWASMSEEQRKEYLKKKREEL--KKKLKEKAKERREKEMLERLEKQKRY----- 580
LE KK+ E++R+E K EE KK+ KE+ K REKE + E++++Y
Sbjct: 334 ALEAKKKEKEDKEKKREELKKIVEEERLKKKEEKERLKVEREKEREKLREEKRKYVEYLK 393
Query: 581 ------EDQELTG-KNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYP-- 631
ED E K LP V T LP +FGD MV+EFL+ + L ++P
Sbjct: 394 QWSKPREDMECDDLKELPEPTPVKTR--LPPEIFGDALMVLEFLNAFGELFDLQDEFPDG 451
Query: 632 ITAVSLMEALSA-DKGGFL--YLNRVLVILLQTLLQDE---------------------- 666
+T L EAL D G L L L + Q + ++E
Sbjct: 452 VTLEVLEEALVGNDSEGPLCELLFFFLTAIFQAIAEEEEEVAKEQLTDADTKDLTEALDE 511
Query: 667 --------------IAEDYGEL--GMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDT 710
+A + +L G L + L ++SE++RL + S S +
Sbjct: 512 DADPTKSALSAVASLAAAWPQLHQGCSLKSLDLDSCTLSEILRLHILASGADVTSANAKY 571
Query: 711 D-------DNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQ 763
D D A E ++KL ++ ++LT EK++IL ALC ++L S +
Sbjct: 572 RYQKRGGFDATDDACMELRLSNPSLVKKLSSTSVYDLTPGEKMKILHALCGKLLTLVSTR 631
Query: 764 D-----------------------HMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKE 800
D H + R++ +A + K + LKE+ K + +++K KE
Sbjct: 632 DFIEDYVDILRQAKQEFRELKAEQHRKEREEAAARIRKRKEEKLKEQEQKMKEKQEKLKE 691
Query: 801 MEAKNKENGKVENGLGKTDRKK----------EIVKFEPQVDTEAEDMISAVKSRRLLAI 850
E +N + +G+ +R+ E + + + TE ED + K R
Sbjct: 692 DEQRNST---ADISIGEEEREDFDTSIESKDTEQKELDQDMVTEDEDDPGSHKRGRRGKR 748
Query: 851 QAKKEREIQEREMKVKLERQA----EEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTD 906
+E +E + R+ EEE +++ EK E I A P+G D
Sbjct: 749 GQNGFKEFTRQEQINCVTREPLTADEEEALKQEHQRKEKELLEKIQSAIACTNIFPLGRD 808
Query: 907 RNHNRYWLFSDEVPGLFIEK---GWVHDSIDYRFNHHCKDHTVSGDEDYCPRSKKANLGK 963
R + RYW+F +PGLFIE+ G D + R + +++ S D ++ + + +
Sbjct: 809 RMYRRYWIFPS-IPGLFIEEDYSGLTEDMLLPRPSSF-QNNVQSQDPQVSTKTGEPLMSE 866
Query: 964 NASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEK 1023
+ S N G +V+ P N W S ++LD+L+ L+ +G RES LKE L +
Sbjct: 867 STS-NIDQGPRDH-SVQLPKPVHKPNRWCFYSSCEQLDQLIEALNSRGHRESALKETLLQ 924
Query: 1024 RYQDIIHSI--------HLARKPNLGLK----------SCDGNQ-----ELLNFLRSDLI 1060
I + H + KP K + D +Q +L LR L+
Sbjct: 925 EKSRICAQLARFSEEKFHFSDKPQPDSKPTYSRGRSSNAYDPSQMCAEKQLELRLRDFLL 984
Query: 1061 EVATRLQKGGLGYVEETSEFEAR---------VISLEKLK---------DFGECVIALQA 1102
++ R+ +G LG ++ T R ++S E + D E I Q
Sbjct: 985 DIEDRIYQGTLGAIKVTDRHIWRSALESGRYELLSEENKENGIIKTVNEDVEEMEIDEQT 1044
Query: 1103 SVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDE----------------EKKMVEEAKVA 1146
VI K + K + S +++ + V E++ ++ A
Sbjct: 1045 KVIVK--DRLLGIKTETPSTVSTNASTPQSVSSVVHYLAMALFQIEQGIERRFLKAPLDA 1102
Query: 1147 S--------ALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDK 1198
S L++W+ ++ + + S++ + L LD + W S NARCK+CRKKG+ +
Sbjct: 1103 SDSGRSYKTVLDRWRESLLSSASLSQVFLHLSTLDRSVIWSKSILNARCKICRKKGDAEN 1162
Query: 1199 LILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDE 1258
++LCD C++ H +C+RP L VP+G+W CP C+P R R + ED ED
Sbjct: 1163 MVLCDGCDRGHHTYCVRPKLKTVPEGDWFCPECRPKQRSRRLSSRQRPSLESDEDVEDSM 1222
Query: 1259 SDEEEE----EEEEEEEEEDYEV------------AGLRLRPRKTI------RGKHSVIP 1296
E++E EEE + EEE+YEV L R R + RGK S
Sbjct: 1223 GGEDDEVDGDEEEGQSEEEEYEVEQDEDDSQEEEEVSLPKRGRPQVRLPVKTRGKLSSSF 1282
Query: 1297 PAARSGRRPGKKPHSTRRSQPK 1318
+ + PG+ P +++S PK
Sbjct: 1283 SSRGQQQEPGRYPSRSQQSTPK 1304
Score = 60.1 bits (144), Expect = 2e-08
Identities = 30/91 (32%), Positives = 54/91 (59%), Gaps = 2/91 (2%)
Query: 1335 KRSSRRQS--LELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVITHPMDFQTVQNK 1392
+RSS RQ EL E+++ ++V++ SWPF + V++ + DYYD+I P+ ++ K
Sbjct: 1423 RRSSGRQGGVHELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREK 1482
Query: 1393 CSCGSYRSVQEFLTDMKQVFTNAEVYNCRGS 1423
+ Y+ EF+ D++ +F+N YN R +
Sbjct: 1483 VNKCEYKLASEFIDDIELMFSNCFEYNPRNT 1513
Score = 57.0 bits (136), Expect = 1e-07
Identities = 48/188 (25%), Positives = 86/188 (45%), Gaps = 15/188 (7%)
Query: 3 PLLGRKPFPLVKP---LPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQ 59
PLL RKPF KP L +E +F T E FR +++ R + +W+C TG
Sbjct: 2 PLLHRKPFVRQKPPADLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPG 61
Query: 60 LTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVH----HNTASLEKLVDTAWLEIMTKYA 115
LT++EA E E++ + L + FP E L++ +++ + + L ++ D + + +Y
Sbjct: 62 LTYQEALESEKKARQNL-QSFP---EPLIIPVLYLTSLTHRSRLHEICDDIFAYVKDRYF 117
Query: 116 VGEECDFEVGKEKMLKVKIVKIHPLEK----VDEEATEKKSDGACDSPSSDKENSSQIAQ 171
V E + L+ +I+++ P + + S S D E S Q
Sbjct: 118 VEETVEVIRNNGARLQCRILEVLPPSHQNGFANGHVNSVDGETIIISDSDDSETQSCSFQ 177
Query: 172 DHQKKETV 179
+ +KK+ +
Sbjct: 178 NGKKKDAI 185
Score = 39.7 bits (91), Expect = 0.022
Identities = 41/186 (22%), Positives = 74/186 (39%), Gaps = 18/186 (9%)
Query: 313 PDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKM 372
P+ +P ++S+ LSS P L ++ S+ G +V + EE E+ +
Sbjct: 1193 PECRPKQRSRR----LSSRQRPSLESDEDVEDSMGGEDDEVDGDEEEGQSEEEEYEVEQD 1248
Query: 373 MSPNKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGR--SKGILNGQKSTGNSKSPKKGLKT 430
++ +PK+G P + P+K +G+ S GQ+ + T
Sbjct: 1249 EDDSQEEEEVSLPKRGRPQVR------LPVKTRGKLSSSFSSRGQQQEPGRYPSRSQQST 1302
Query: 431 PKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKP--HKHLPPAALHLIAYYKENKDR 488
PKT + T + +K+ AP + R +S+ H H P A + + R
Sbjct: 1303 PKTTVSSKT----GRSLRKINSAPPTETKSLRIASRSTRHSHGPLQADVFVELLSPRRKR 1358
Query: 489 EDKRSA 494
++SA
Sbjct: 1359 RGRKSA 1364
>gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo
sapiens]
Length = 2168
Score = 142 bits (357), Expect = 3e-33
Identities = 118/497 (23%), Positives = 212/497 (42%), Gaps = 56/497 (11%)
Query: 947 SGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNC 1006
S E P+++KA + A++ + P++ Q W+ ++L LL
Sbjct: 1676 SKSESPVPQNEKATSAQPAAVEV--AKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKV 1733
Query: 1007 LHPQGIRESQLKERLEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIE---VA 1063
LH +GIRE L+++++K + D I L K ++ + + N+E N + D++E V
Sbjct: 1734 LHLRGIREKALQKQIQK-HLDYITQACLKNK-DVAIIELNENEE--NQVTRDIVENWSVE 1789
Query: 1064 TRLQKGGLGYVEETSEFEARVISLE-KLKDF--------GECVIALQASVIKKFLQGF-- 1112
+ + L +++ + E RV S ++K + E ++ + K +
Sbjct: 1790 EQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDG 1849
Query: 1113 --------MAPKQKRRKLQSEDSAKTEEVDEEKKMVE--EAKVASALEKWKTAIREAQTF 1162
A +R+ D A T D E+ + E +A L W+ A+ EA++
Sbjct: 1850 EFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSA 1909
Query: 1163 SRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVP 1222
+++ + + L I W+ S C++CRK ++ L+LCD C+K H +C RP + +P
Sbjct: 1910 AQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIP 1969
Query: 1223 DGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDYEVAGLRL 1282
DG+W CPAC A+ + + + ++ ++ + E+ED
Sbjct: 1970 DGDWFCPAC---IAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDED-------- 2018
Query: 1283 RPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQS 1342
+ S + G K R+ + + E K+ R S
Sbjct: 2019 -------------SASTSSSLKRGNKDLKKRKMEENTS--INLSKQESFTSVKKPKRDDS 2063
Query: 1343 LELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVITHPMDFQTVQNKCSCGSYRSVQ 1402
+L C IL ++ + +WPF PV Y VI PMDF T++ K S G Y +++
Sbjct: 2064 KDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLE 2123
Query: 1403 EFLTDMKQVFTNAEVYN 1419
F D++ VF N E +N
Sbjct: 2124 TFALDVRLVFDNCETFN 2140
Score = 55.8 bits (133), Expect = 3e-07
Identities = 96/460 (20%), Positives = 185/460 (40%), Gaps = 76/460 (16%)
Query: 503 ARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKA 562
A+LL +E R + E R ++ LL+H++R E +R+ + K E +KK +EK
Sbjct: 978 AKLLEAEKRIKEKEMRR----QQAVLLKHQER-----ERRRQHMMLMKAMEARKKAEEKE 1028
Query: 563 KERREKEMLERLEKQKRYEDQELTGKNLPAFR-------LVD---TPE-------GLPNT 605
+ ++EK +RL K+++ E + L + + L D PE L +
Sbjct: 1029 RLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRIPGLVLSGS 1088
Query: 606 LFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFL-YLNRVLVILLQTLLQ 664
F D MVV+FL + +L D + +S+++ + G + + +LV LL +
Sbjct: 1089 TFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLVRLLSAAVC 1148
Query: 665 DE-IAEDY---GELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFE 720
D + Y LG L + + +VSE++++ + E
Sbjct: 1149 DPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFM-----------------------E 1185
Query: 721 DNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKER 780
+ Q E E L+T F T +K +L L + + + SV ++ + L +++
Sbjct: 1186 AHCGQTELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDK 1245
Query: 781 LAV------LKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKK---------EIV 825
V L+ + KK ++ ++ +++ G+ R+K +
Sbjct: 1246 WVVEGKLRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDD 1305
Query: 826 KFEPQVDTEAEDMISAVKSRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEK 885
+ Q D + ED + + E E + +LE+Q E+ + +
Sbjct: 1306 DSDDQGDEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEK------LSKQQS 1359
Query: 886 AFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIE 925
++ + A +R G DR RYW+ + G+F+E
Sbjct: 1360 QYRRKLFDASHSLRSVMFGQDRYRRRYWIL-PQCGGIFVE 1398
Score = 37.4 bits (85), Expect = 0.11
Identities = 14/25 (56%), Positives = 22/25 (88%)
Query: 1250 ASEDSEDDESDEEEEEEEEEEEEED 1274
+S+DSED DEEE++EEE+EE+++
Sbjct: 600 SSKDSEDSNEDEEEDDEEEDEEDDE 624
Score = 37.4 bits (85), Expect = 0.11
Identities = 18/51 (35%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Query: 1224 GEWQCPACQPATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEED 1274
GE Q P P R+ R R + +D +DD D+ +E++E+EE++ED
Sbjct: 1275 GEEQHPLGTPTPGRK--RRRKGGDSDYDDDDDDDSDDQGDEDDEDEEDKED 1323
Score = 35.4 bits (80), Expect = 0.41
Identities = 12/24 (50%), Positives = 22/24 (91%)
Query: 1251 SEDSEDDESDEEEEEEEEEEEEED 1274
SEDS +DE +++EEE+EE++E+++
Sbjct: 604 SEDSNEDEEEDDEEEDEEDDEDDE 627
Score = 34.7 bits (78), Expect = 0.70
Identities = 27/94 (28%), Positives = 44/94 (46%), Gaps = 7/94 (7%)
Query: 1246 TEESASEDSEDDESDEEEEE---EEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSG 1302
+E +S DS+D E DEEEE+ EE E+++ D E + + H + P A G
Sbjct: 257 SEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQVL--LHGISDPKA-DG 313
Query: 1303 RRPGKKPHSTRRSQPKAPPVDDAEVDELVLQTKR 1336
++ +K R QP P +++ Q K+
Sbjct: 314 QKATEKAQEKRIHQP-LPLASESQTHSFQSQQKQ 346
Score = 33.5 bits (75), Expect = 1.6
Identities = 11/31 (35%), Positives = 23/31 (74%)
Query: 1246 TEESASEDSEDDESDEEEEEEEEEEEEEDYE 1276
+E+S ++ EDDE ++EE++E++E ++ E
Sbjct: 604 SEDSNEDEEEDDEEEDEEDDEDDESDDSQSE 634
Score = 32.7 bits (73), Expect = 2.7
Identities = 31/109 (28%), Positives = 60/109 (55%), Gaps = 8/109 (7%)
Query: 500 SKTARLLSSEDRARLPEELRSL--VQKRYELL---EHKKRWASMS-EEQRKEYLKKKREE 553
+K R L +++ AR +++ L +QK+ + E KK+ A M+ EE+RK+ + K +
Sbjct: 883 AKLLRKLQAQEIARQAAQIKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMK 942
Query: 554 LKKKLKEKAKERREKEMLER--LEKQKRYEDQELTGKNLPAFRLVDTPE 600
++K+K + R EKE+ + LE +K+ +++ K L A + + E
Sbjct: 943 QQEKIKRIQQIRMEKELRAQQILEAKKKKKEEAANAKLLEAEKRIKEKE 991
Score = 32.3 bits (72), Expect = 3.5
Identities = 12/47 (25%), Positives = 22/47 (46%)
Query: 1233 PATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDYEVAG 1279
P++ + E+ ED EDDE DE ++ + E + + + G
Sbjct: 599 PSSKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEG 645
Score = 31.2 bits (69), Expect = 7.8
Identities = 16/50 (32%), Positives = 25/50 (50%), Gaps = 17/50 (34%)
Query: 1247 EESASEDSEDDESD-----------------EEEEEEEEEEEEEDYEVAG 1279
EE ED EDDESD EEE++++++++E D + G
Sbjct: 616 EEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESDSDTEG 665
>gi|91176325 bromodomain adjacent to zinc finger domain, 2A [Homo
sapiens]
Length = 1905
Score = 117 bits (292), Expect = 1e-25
Identities = 74/285 (25%), Positives = 121/285 (42%), Gaps = 44/285 (15%)
Query: 1144 KVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCD 1203
++ + W+ + ++ +++ + LG L+ I W+ S C VCRK D+ L+LCD
Sbjct: 1636 EITPRIRVWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCD 1695
Query: 1204 ECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESDEEE 1263
C++ H++C RP + VP+G+W C C ++ E + + +
Sbjct: 1696 GCDRGCHIYCHRPKMEAVPEGDWFCTVC------------------LAQQVEGEFTQKPG 1737
Query: 1264 EEEEEEEEEEDYEV---AGLRLRPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAP 1320
+ ++ + Y + G R R +RG+ S P A G P RR
Sbjct: 1738 FPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRES--PAAGPRYSEEGLSPSKRRR------ 1789
Query: 1321 PVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVI 1380
S R +L CE IL ++ + +WPF EPV Y +I
Sbjct: 1790 ---------------LSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRII 1834
Query: 1381 THPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHV 1425
+PMDF T++ + G Y S +EF D VF N + +N S V
Sbjct: 1835 KNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEV 1879
Score = 85.5 bits (210), Expect = 3e-16
Identities = 129/554 (23%), Positives = 221/554 (39%), Gaps = 105/554 (18%)
Query: 415 QKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPA 474
Q TG P+ T K K K++ + +G + +T ++P K L
Sbjct: 646 QAITGKRGRPRN---TEKAKTKEVPKVKRGRGRPPKVKITELLN---KTDNRPLKKLEA- 698
Query: 475 ALHLIAYYKENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKR 534
+E + EDK ++ E + + + R+ +++ E K++
Sbjct: 699 --------QETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARN--KRKQETKSLKQK 748
Query: 535 WASMSEEQRKEYLKKKREELKKKLKEKAKER---REKEML----------------ERLE 575
A + KE K K+E+LK+K+K + KE+ +EKE + RLE
Sbjct: 749 EAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLE 808
Query: 576 KQKRY-----------EDQELTG-KNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGL 623
+++R ED LT + LP F V LP+ F D +VEFL + +
Sbjct: 809 ERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRVPGLT-LPSGAFSDCLTIVEFLHSFGKV 867
Query: 624 LLPDAQYPITAVS-LMEALSADKGGFLYLNRVLVILLQTLLQDEIAEDYGE----LGMKL 678
L D + ++ L E L + +LV LL+ L D Y + LG K+
Sbjct: 868 LGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLKAALHDPGFPSYCQSLKILGEKV 927
Query: 679 SEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFF 738
SEIPLT +VSE++R L V+ ++L T F
Sbjct: 928 SEIPLTRDNVSEILRCFLMAYG-----------------------VEPALCDRLRTQPFQ 964
Query: 739 ELTSEEKLQILTALCHRI----LMTYSVQDHMETRQQMSAELW--KERLAVLKEENDKKR 792
++K +L L H + L+ + +E+ W + RL LK
Sbjct: 965 AQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLK----TVL 1020
Query: 793 AEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVKSRRLLAIQA 852
A++ R E+E + E LG+ + + + + E E+ I+AV RR
Sbjct: 1021 AKRTGRSEVEMEGP-----EECLGRRRSSRIMEETSGMEEEEEEESIAAVPGRR-----G 1070
Query: 853 KKEREIQEREMKV-KLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNR 911
+++ E+ + +LERQ E+ R + F++ + + ++R +G DR R
Sbjct: 1071 RRDGEVDATASSIPELERQIEKLSKR------QLFFRKKLLHSSQMLRAVSLGQDRYRRR 1124
Query: 912 YWLFSDEVPGLFIE 925
YW+ + G+F+E
Sbjct: 1125 YWVL-PYLAGIFVE 1137
Score = 37.7 bits (86), Expect = 0.083
Identities = 19/60 (31%), Positives = 33/60 (55%), Gaps = 2/60 (3%)
Query: 975 TEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEKRYQDIIHSIHL 1034
T++ + P+ W++ D + LD +L LHP+GIRE L + L K ++D + + L
Sbjct: 1424 TQLTAQPVPPEMCSGWWWIRDPEM-LDAMLKALHPRGIREKALHKHLNK-HRDFLQEVCL 1481
>gi|148612882 cat eye syndrome chromosome region, candidate 2 [Homo
sapiens]
Length = 1484
Score = 81.3 bits (199), Expect = 7e-15
Identities = 54/194 (27%), Positives = 87/194 (44%), Gaps = 5/194 (2%)
Query: 1258 ESDEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKH-SVIPPAARSGRRPGKKPHSTRRSQ 1316
E ++ +EE + E EE + R RG S P R+ RR ++ + +Q
Sbjct: 348 EQEQMLKEERKRELEEKVKAVEGMCSVRVVWRGACLSTSRPVDRAKRRKLREERAWLLAQ 407
Query: 1317 PKAPPVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIVK----YRFSWPFREPVTRDE 1372
K P + + +D + + EL ++K++ ++ SWPF EPV
Sbjct: 408 GKELPPELSHLDPNSPMREEKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESY 467
Query: 1373 AEDYYDVITHPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKT 1432
A +YY +I PMD +++ K + G Y + +EF+ DMK +F N YN S
Sbjct: 468 APNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNL 527
Query: 1433 EQCLVALLHKHLPG 1446
E+C + KH PG
Sbjct: 528 ERCFHRAMMKHFPG 541
>gi|52630326 chromodomain helicase DNA binding protein 3 isoform 1
[Homo sapiens]
Length = 2000
Score = 74.3 bits (181), Expect = 8e-13
Identities = 35/89 (39%), Positives = 53/89 (59%), Gaps = 15/89 (16%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYT 1246
C+VC++ GE +ILCD C +A+HL CL P L P+G+W CP C+ + ++
Sbjct: 382 CEVCQQGGE---IILCDTCPRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQWEAK----- 433
Query: 1247 EESASEDSEDDESDEEEEEEEEEEEEEDY 1275
E++E +EE EEE E+EEE+D+
Sbjct: 434 -------EEEEEYEEEGEEEGEKEEEDDH 455
Score = 56.6 bits (135), Expect = 2e-07
Identities = 21/45 (46%), Positives = 30/45 (66%), Gaps = 3/45 (6%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPAC 1231
C+VC+ GE L+ CD C ++H+ CL P L ++P+GEW CP C
Sbjct: 459 CRVCKDGGE---LLCCDACISSYHIHCLNPPLPDIPNGEWLCPRC 500
>gi|52630322 chromodomain helicase DNA binding protein 3 isoform 2
[Homo sapiens]
Length = 1966
Score = 74.3 bits (181), Expect = 8e-13
Identities = 35/89 (39%), Positives = 53/89 (59%), Gaps = 15/89 (16%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYT 1246
C+VC++ GE +ILCD C +A+HL CL P L P+G+W CP C+ + ++
Sbjct: 382 CEVCQQGGE---IILCDTCPRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQWEAK----- 433
Query: 1247 EESASEDSEDDESDEEEEEEEEEEEEEDY 1275
E++E +EE EEE E+EEE+D+
Sbjct: 434 -------EEEEEYEEEGEEEGEKEEEDDH 455
Score = 56.6 bits (135), Expect = 2e-07
Identities = 21/45 (46%), Positives = 30/45 (66%), Gaps = 3/45 (6%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPAC 1231
C+VC+ GE L+ CD C ++H+ CL P L ++P+GEW CP C
Sbjct: 459 CRVCKDGGE---LLCCDACISSYHIHCLNPPLPDIPNGEWLCPRC 500
>gi|158420731 chromodomain helicase DNA binding protein 3 isoform 3
[Homo sapiens]
Length = 2059
Score = 74.3 bits (181), Expect = 8e-13
Identities = 35/89 (39%), Positives = 53/89 (59%), Gaps = 15/89 (16%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYT 1246
C+VC++ GE +ILCD C +A+HL CL P L P+G+W CP C+ + ++
Sbjct: 441 CEVCQQGGE---IILCDTCPRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQWEAK----- 492
Query: 1247 EESASEDSEDDESDEEEEEEEEEEEEEDY 1275
E++E +EE EEE E+EEE+D+
Sbjct: 493 -------EEEEEYEEEGEEEGEKEEEDDH 514
Score = 56.6 bits (135), Expect = 2e-07
Identities = 21/45 (46%), Positives = 30/45 (66%), Gaps = 3/45 (6%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPAC 1231
C+VC+ GE L+ CD C ++H+ CL P L ++P+GEW CP C
Sbjct: 518 CRVCKDGGE---LLCCDACISSYHIHCLNPPLPDIPNGEWLCPRC 559
Score = 40.8 bits (94), Expect = 0.010
Identities = 30/95 (31%), Positives = 40/95 (42%), Gaps = 2/95 (2%)
Query: 1246 TEESASEDSEDDESDEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRP 1305
+EE E+ E DE +EEE E +E++EED + L P RG+ PP P
Sbjct: 18 SEEEEEEEEEGDEEEEEEVEAADEDDEEDDDEGVLGRGPGHD-RGRDRHSPPGCHLFPPP 76
Query: 1306 GKKPHSTRRSQPKAPP-VDDAEVDELVLQTKRSSR 1339
P P PP DD + L K+ R
Sbjct: 77 PPPPPPLPPPPPPPPPDKDDIRLLPSALGVKKRKR 111
>gi|226442963 jumonji, AT rich interactive domain 1C isoform 2 [Homo
sapiens]
Length = 1379
Score = 73.2 bits (178), Expect = 2e-12
Identities = 49/167 (29%), Positives = 74/167 (44%), Gaps = 25/167 (14%)
Query: 1111 GFMAPKQKRRKLQSEDSAKTEEVDEEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLG 1170
G MA + RK E V ++++ + KV S K +E + S
Sbjct: 182 GLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSP------ 235
Query: 1171 MLDACIKWDMSA----------ENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYE 1220
+ C K M E+ C++C + EDDKL+LCD C+ +H+FCL P L E
Sbjct: 236 --EPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPE 293
Query: 1221 VPDGEWQCPACQPATARR-------NSRGRNYTEESASEDSEDDESD 1260
+P G W+CP C A +R R YT +S E ++ ++D
Sbjct: 294 IPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKAD 340
>gi|109255243 jumonji, AT rich interactive domain 1C isoform 1 [Homo
sapiens]
Length = 1560
Score = 73.2 bits (178), Expect = 2e-12
Identities = 49/167 (29%), Positives = 74/167 (44%), Gaps = 25/167 (14%)
Query: 1111 GFMAPKQKRRKLQSEDSAKTEEVDEEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLG 1170
G MA + RK E V ++++ + KV S K +E + S
Sbjct: 249 GLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSP------ 302
Query: 1171 MLDACIKWDMSA----------ENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYE 1220
+ C K M E+ C++C + EDDKL+LCD C+ +H+FCL P L E
Sbjct: 303 --EPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPE 360
Query: 1221 VPDGEWQCPACQPATARR-------NSRGRNYTEESASEDSEDDESD 1260
+P G W+CP C A +R R YT +S E ++ ++D
Sbjct: 361 IPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKAD 407
>gi|164419758 bromodomain containing 2 [Homo sapiens]
Length = 801
Score = 72.0 bits (175), Expect = 4e-12
Identities = 50/172 (29%), Positives = 80/172 (46%), Gaps = 23/172 (13%)
Query: 1284 PRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQSL 1343
P ++ K + +PP R RP K P R+ P + Q +SS++ L
Sbjct: 302 PPGSLEPKAARLPPMRRESGRPIKPP---RKDLPDSQ------------QQHQSSKKGKL 346
Query: 1344 --ELQKCEEILHKIVKYR---FSWPFREPVTRDEA--EDYYDVITHPMDFQTVQNKCSCG 1396
+L+ C IL +++ + ++WPF +PV DY+D+I HPMD TV+ K
Sbjct: 347 SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENR 406
Query: 1397 SYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLVALLHKHLPGHP 1448
YR QEF D++ +F+N YN H + M + Q + + +P P
Sbjct: 407 DYRDAQEFAADVRLMFSNCYKYN-PPDHDVVAMARKLQDVFEFRYAKMPDEP 457
Score = 56.2 bits (134), Expect = 2e-07
Identities = 27/77 (35%), Positives = 43/77 (55%), Gaps = 7/77 (9%)
Query: 1350 EILHKIV-----KYRFSWPFREPVTRDEA--EDYYDVITHPMDFQTVQNKCSCGSYRSVQ 1402
+ LHK+V K++F+WPFR+PV + DY+ +I PMD T++ + Y +
Sbjct: 80 QYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAAS 139
Query: 1403 EFLTDMKQVFTNAEVYN 1419
E + D +FTN +YN
Sbjct: 140 ECMQDFNTMFTNCYIYN 156
Score = 43.5 bits (101), Expect = 0.002
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 1230 ACQPATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDYEVAGLRLRP-RKTI 1288
A P A+ +S + S S E++E DEE+EEEEE E + E RL ++ +
Sbjct: 468 AMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQL 527
Query: 1289 RGKHSVIP-----PAARSGRRPGKKPHSTRRSQPK 1318
R H + P ++ R+ KK +R K
Sbjct: 528 RAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEK 562
Score = 42.4 bits (98), Expect = 0.003
Identities = 21/57 (36%), Positives = 34/57 (59%)
Query: 1220 EVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDYE 1276
++PD + +TA ++ +E S+ E S + S+EEEEE+EE+EEEE+ E
Sbjct: 452 KMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESE 508
>gi|4826806 bromodomain containing 2 [Homo sapiens]
Length = 801
Score = 72.0 bits (175), Expect = 4e-12
Identities = 50/172 (29%), Positives = 80/172 (46%), Gaps = 23/172 (13%)
Query: 1284 PRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQSL 1343
P ++ K + +PP R RP K P R+ P + Q +SS++ L
Sbjct: 302 PPGSLEPKAARLPPMRRESGRPIKPP---RKDLPDSQ------------QQHQSSKKGKL 346
Query: 1344 --ELQKCEEILHKIVKYR---FSWPFREPVTRDEA--EDYYDVITHPMDFQTVQNKCSCG 1396
+L+ C IL +++ + ++WPF +PV DY+D+I HPMD TV+ K
Sbjct: 347 SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENR 406
Query: 1397 SYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLVALLHKHLPGHP 1448
YR QEF D++ +F+N YN H + M + Q + + +P P
Sbjct: 407 DYRDAQEFAADVRLMFSNCYKYN-PPDHDVVAMARKLQDVFEFRYAKMPDEP 457
Score = 56.2 bits (134), Expect = 2e-07
Identities = 27/77 (35%), Positives = 43/77 (55%), Gaps = 7/77 (9%)
Query: 1350 EILHKIV-----KYRFSWPFREPVTRDEA--EDYYDVITHPMDFQTVQNKCSCGSYRSVQ 1402
+ LHK+V K++F+WPFR+PV + DY+ +I PMD T++ + Y +
Sbjct: 80 QYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAAS 139
Query: 1403 EFLTDMKQVFTNAEVYN 1419
E + D +FTN +YN
Sbjct: 140 ECMQDFNTMFTNCYIYN 156
Score = 43.5 bits (101), Expect = 0.002
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 1230 ACQPATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDYEVAGLRLRP-RKTI 1288
A P A+ +S + S S E++E DEE+EEEEE E + E RL ++ +
Sbjct: 468 AMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQL 527
Query: 1289 RGKHSVIP-----PAARSGRRPGKKPHSTRRSQPK 1318
R H + P ++ R+ KK +R K
Sbjct: 528 RAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEK 562
Score = 42.4 bits (98), Expect = 0.003
Identities = 21/57 (36%), Positives = 34/57 (59%)
Query: 1220 EVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDYE 1276
++PD + +TA ++ +E S+ E S + S+EEEEE+EE+EEEE+ E
Sbjct: 452 KMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESE 508
>gi|24308089 chromodomain helicase DNA binding protein 5 [Homo
sapiens]
Length = 1954
Score = 71.2 bits (173), Expect = 7e-12
Identities = 51/162 (31%), Positives = 79/162 (48%), Gaps = 34/162 (20%)
Query: 1118 KRRKLQSEDSAKTEEVDEEKKMVEEAKVAS----ALEKWKTAIREAQTFSRMHVLLGMLD 1173
KR+K S + + EE D + + A V S AL K R+ + +D
Sbjct: 284 KRKKGSSSEEDEREESDFDSASIHSASVRSECSAALGKKSKRRRKKKR----------ID 333
Query: 1174 ACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQP 1233
++ ++ C+VC++ GE +ILCD C +A+HL CL P L + P+G+W CP C+
Sbjct: 334 DGDGYETDHQDY-CEVCQQGGE---IILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCE- 388
Query: 1234 ATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDY 1275
+E + +DD D+EEEE EEEE+D+
Sbjct: 389 -------------KEGIQWEPKDD--DDEEEEGGCEEEEDDH 415
Score = 58.9 bits (141), Expect = 3e-08
Identities = 23/45 (51%), Positives = 30/45 (66%), Gaps = 3/45 (6%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPAC 1231
C+VC+ GE L+ CD C ++HL CL P L E+P+GEW CP C
Sbjct: 419 CRVCKDGGE---LLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRC 460
>gi|11067749 bromodomain containing protein 3 [Homo sapiens]
Length = 726
Score = 68.6 bits (166), Expect = 4e-11
Identities = 47/166 (28%), Positives = 73/166 (43%), Gaps = 7/166 (4%)
Query: 1288 IRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQSLELQK 1347
I S PP ++ +P PP D E E V Q + S L+
Sbjct: 256 ITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGE-VPQHAGKKGKLSEHLRY 314
Query: 1348 CEEILHKIVKYR---FSWPFREPVTRD--EAEDYYDVITHPMDFQTVQNKCSCGSYRSVQ 1402
C+ IL +++ + ++WPF +PV + E DY+D+I HPMD TV+ K Y Q
Sbjct: 315 CDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQ 374
Query: 1403 EFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLVALLHKHLPGHP 1448
F D++ +F+N YN H + M + Q + + +P P
Sbjct: 375 GFAADVRLMFSNCYKYN-PPDHEVVAMARKLQDVFEMRFAKMPDEP 419
Score = 55.1 bits (131), Expect = 5e-07
Identities = 27/83 (32%), Positives = 48/83 (57%), Gaps = 3/83 (3%)
Query: 1340 RQSLELQKCEEILHKIV-KYRFSWPFREPVTRDEAE--DYYDVITHPMDFQTVQNKCSCG 1396
R++ +LQ + ++ K + K++F+WPF +PV + DY+ +I +PMD T++ +
Sbjct: 34 RKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENN 93
Query: 1397 SYRSVQEFLTDMKQVFTNAEVYN 1419
Y S E + D +FTN +YN
Sbjct: 94 YYWSASECMQDFNTMFTNCYIYN 116
Score = 38.5 bits (88), Expect = 0.049
Identities = 51/217 (23%), Positives = 86/217 (39%), Gaps = 54/217 (24%)
Query: 1220 EVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESDEEE---------------- 1263
++PD + PA A S+G + S S+ SD EE
Sbjct: 414 KMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAV 473
Query: 1264 -------------------EEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPA--ARSG 1302
E++E+E++++D E + + + K V PPA A+
Sbjct: 474 HEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQK 533
Query: 1303 RRPGKKPHST-------RRSQPKAPPVDDAEVDELVLQTKRSSRRQ-SLELQKCE-EILH 1353
+ P KK +ST ++ +A D+E +E L +RQ SL++ + E L
Sbjct: 534 KAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLG 593
Query: 1354 KIVKYRFSWPFREPVTRDEAEDYYDVITHPMDFQTVQ 1390
++V S REP RD D ++ DF+T++
Sbjct: 594 RVVHIIQS---REPSLRDSNPDEIEI-----DFETLK 622
Score = 33.9 bits (76), Expect = 1.2
Identities = 68/279 (24%), Positives = 109/279 (39%), Gaps = 27/279 (9%)
Query: 462 RTSSKPHKHLPPAALHLIAYYKENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSL 521
R + P + + AL A +K E RS+ S + S E+RA EL+
Sbjct: 411 RFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESS-SDSGSSDSEEERATRLAELQEQ 469
Query: 522 VQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLERLEKQKRYE 581
++ +E L + +++KE KK +E KKK KEK KE+ + + E + +
Sbjct: 470 LKAVHEQLAALSQAPVNKPKKKKE---KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPP 526
Query: 582 DQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSL-MEA 640
++ K PA + T G + S LP + +SL +
Sbjct: 527 AKQAQQKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINR 586
Query: 641 LSADKGGFLYLNRVLVIL------LQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRL 694
L +K L RV+ I+ L+ DEI D+ L P TL + V+
Sbjct: 587 LPGEK-----LGRVVHIIQSREPSLRDSNPDEIEIDFETLK------PTTLRELERYVKS 635
Query: 695 CLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLE 733
CL Q++ + K AA E+ E ++LE
Sbjct: 636 CL-----QKKQRKPFSASGKKQAAKSKEELAQEKKKELE 669
>gi|7657218 bromodomain-containing protein 4 isoform short [Homo
sapiens]
Length = 722
Score = 67.4 bits (163), Expect = 1e-10
Identities = 45/158 (28%), Positives = 74/158 (46%), Gaps = 7/158 (4%)
Query: 1296 PPAARSGRRPGKKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKI 1355
PP+ + K S+P PP D + ++SS+ S +L+ C IL ++
Sbjct: 306 PPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSK-VSEQLKCCSGILKEM 364
Query: 1356 VKYR---FSWPFREPVTRDEA--EDYYDVITHPMDFQTVQNKCSCGSYRSVQEFLTDMKQ 1410
+ ++WPF +PV + DY D+I HPMD T+++K YR QEF D++
Sbjct: 365 FAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRL 424
Query: 1411 VFTNAEVYNCRGSHVLSCMVKTEQCLVALLHKHLPGHP 1448
+F+N YN H + M + Q + + +P P
Sbjct: 425 MFSNCYKYN-PPDHEVVAMARKLQDVFEMRFAKMPDEP 461
Score = 63.5 bits (153), Expect = 1e-09
Identities = 36/121 (29%), Positives = 65/121 (53%), Gaps = 5/121 (4%)
Query: 1311 STRRSQPKAPPVDDAEVDELVLQTKRSSR--RQSLELQKCEEILHKIV-KYRFSWPFREP 1367
ST ++Q + P + A + +T ++ RQ+ +LQ ++ K + K++F+WPF++P
Sbjct: 27 STTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQP 86
Query: 1368 V--TRDEAEDYYDVITHPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHV 1425
V + DYY +I PMD T++ + Y + QE + D +FTN +YN G +
Sbjct: 87 VDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDI 146
Query: 1426 L 1426
+
Sbjct: 147 V 147
Score = 35.4 bits (80), Expect = 0.41
Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 9/97 (9%)
Query: 507 SSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERR 566
S E+RA+ EL+ ++ +E L A++S+ Q+ K K++E KK K+K K +R
Sbjct: 503 SEEERAQRLAELQEQLKAVHEQL------AALSQPQQN---KPKKKEKDKKEKKKEKHKR 553
Query: 567 EKEMLERLEKQKRYEDQELTGKNLPAFRLVDTPEGLP 603
++E+ E + + + + T KN + V E P
Sbjct: 554 KEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAP 590
Score = 31.2 bits (69), Expect = 7.8
Identities = 32/145 (22%), Positives = 63/145 (43%), Gaps = 18/145 (12%)
Query: 1247 EESASEDSEDDESDEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPG 1306
+ + +D + ++E+ + +EE EE+ + P+KT + S
Sbjct: 533 QNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNN--------SSNSNVS 584
Query: 1307 KKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQSLELQKCE-EILHKIVKYRFSWPFR 1365
KK + +S+P P + E D+ + R+ SL++ K E L ++V S R
Sbjct: 585 KKEPAPMKSKP-PPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQS---R 640
Query: 1366 EPVTRDEAEDYYDVITHPMDFQTVQ 1390
EP ++ D ++ DF+T++
Sbjct: 641 EPSLKNSNPDEIEI-----DFETLK 660
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 67.4 bits (163), Expect = 1e-10
Identities = 45/158 (28%), Positives = 74/158 (46%), Gaps = 7/158 (4%)
Query: 1296 PPAARSGRRPGKKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKI 1355
PP+ + K S+P PP D + ++SS+ S +L+ C IL ++
Sbjct: 306 PPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSK-VSEQLKCCSGILKEM 364
Query: 1356 VKYR---FSWPFREPVTRDEA--EDYYDVITHPMDFQTVQNKCSCGSYRSVQEFLTDMKQ 1410
+ ++WPF +PV + DY D+I HPMD T+++K YR QEF D++
Sbjct: 365 FAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRL 424
Query: 1411 VFTNAEVYNCRGSHVLSCMVKTEQCLVALLHKHLPGHP 1448
+F+N YN H + M + Q + + +P P
Sbjct: 425 MFSNCYKYN-PPDHEVVAMARKLQDVFEMRFAKMPDEP 461
Score = 63.5 bits (153), Expect = 1e-09
Identities = 36/121 (29%), Positives = 65/121 (53%), Gaps = 5/121 (4%)
Query: 1311 STRRSQPKAPPVDDAEVDELVLQTKRSSR--RQSLELQKCEEILHKIV-KYRFSWPFREP 1367
ST ++Q + P + A + +T ++ RQ+ +LQ ++ K + K++F+WPF++P
Sbjct: 27 STTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQP 86
Query: 1368 V--TRDEAEDYYDVITHPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHV 1425
V + DYY +I PMD T++ + Y + QE + D +FTN +YN G +
Sbjct: 87 VDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDI 146
Query: 1426 L 1426
+
Sbjct: 147 V 147
Score = 37.4 bits (85), Expect = 0.11
Identities = 46/216 (21%), Positives = 88/216 (40%), Gaps = 24/216 (11%)
Query: 375 PNKLHTNFHIPKKGPPAKKP---GKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTP 431
P + H+P++ P KP G+ +P + G + K K+ KTP
Sbjct: 1137 PESIKAPVHLPQR--PEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQ-------KQEPKTP 1187
Query: 432 KTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYKENKDREDK 491
K + + +M + + P T ++SS + AA +E ++RE
Sbjct: 1188 VAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAA-------REKEEREKA 1240
Query: 492 RSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKR 551
A + K L E R R E+ +L Q R E +R ++QR+E ++++
Sbjct: 1241 LKAQAEHAEKEKERLRQE-RMRSREDEDALEQAR-RAHEEARRRQEQQQQQRQEQQQQQQ 1298
Query: 552 EE---LKKKLKEKAKERREKEMLERLEKQKRYEDQE 584
++ + +A+ + + ML++ + R +QE
Sbjct: 1299 QQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQE 1334
Score = 35.4 bits (80), Expect = 0.41
Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 9/97 (9%)
Query: 507 SSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERR 566
S E+RA+ EL+ ++ +E L A++S+ Q+ K K++E KK K+K K +R
Sbjct: 503 SEEERAQRLAELQEQLKAVHEQL------AALSQPQQN---KPKKKEKDKKEKKKEKHKR 553
Query: 567 EKEMLERLEKQKRYEDQELTGKNLPAFRLVDTPEGLP 603
++E+ E + + + + T KN + V E P
Sbjct: 554 KEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAP 590
Score = 31.2 bits (69), Expect = 7.8
Identities = 32/145 (22%), Positives = 63/145 (43%), Gaps = 18/145 (12%)
Query: 1247 EESASEDSEDDESDEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPG 1306
+ + +D + ++E+ + +EE EE+ + P+KT + S
Sbjct: 533 QNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNN--------SSNSNVS 584
Query: 1307 KKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQSLELQKCE-EILHKIVKYRFSWPFR 1365
KK + +S+P P + E D+ + R+ SL++ K E L ++V S R
Sbjct: 585 KKEPAPMKSKP-PPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQS---R 640
Query: 1366 EPVTRDEAEDYYDVITHPMDFQTVQ 1390
EP ++ D ++ DF+T++
Sbjct: 641 EPSLKNSNPDEIEI-----DFETLK 660
>gi|40805843 K(lysine) acetyltransferase 2B [Homo sapiens]
Length = 832
Score = 67.0 bits (162), Expect = 1e-10
Identities = 31/80 (38%), Positives = 47/80 (58%)
Query: 1349 EEILHKIVKYRFSWPFREPVTRDEAEDYYDVITHPMDFQTVQNKCSCGSYRSVQEFLTDM 1408
+ IL ++ ++ +WPF EPV R EA YY+VI PMD +T+ + Y S + F+ D+
Sbjct: 733 KSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADL 792
Query: 1409 KQVFTNAEVYNCRGSHVLSC 1428
++VFTN + YN S C
Sbjct: 793 QRVFTNCKEYNPPESEYYKC 812
>gi|57242796 jumonji, AT rich interactive domain 1B [Homo sapiens]
Length = 1544
Score = 66.6 bits (161), Expect = 2e-10
Identities = 44/157 (28%), Positives = 76/157 (48%), Gaps = 32/157 (20%)
Query: 1111 GFMAPKQKRRKLQSEDSAKTEEVDEEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLG 1170
G PK + K + + S K E ++ + +VE K EK K+ ++A ++V
Sbjct: 261 GCPTPKCENEK-EMKSSIKQEPIERKDYIVENEK-----EKPKSRSKKATNAVDLYV--- 311
Query: 1171 MLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPA 1230
C +C ++D+L+LCD C+ ++H FCL P L++VP G+W+CP
Sbjct: 312 ----------------CLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPK 355
Query: 1231 C--QPATARRNSRG-----RNYTEESASEDSEDDESD 1260
C Q + + + G R+YT + E ++ +SD
Sbjct: 356 CLAQECSKPQEAFGFEQAARDYTLRTFGEMADAFKSD 392
Score = 36.2 bits (82), Expect = 0.24
Identities = 37/138 (26%), Positives = 61/138 (44%), Gaps = 28/138 (20%)
Query: 1111 GFMAPKQKRRKLQS------EDSAKTEEV-DEEKKMVEEAKVASALEKWKTA-IREAQTF 1162
G + K+K+RKL+ + S K E + D E+ + E + ASA+ A +RE +
Sbjct: 1097 GLLGLKRKQRKLKEPLPNGKKKSTKLESLSDLERALTESKETASAMATLGEARLREMEAL 1156
Query: 1163 SRMHV-----LLGMLDACIKWDMSAENARCKVCR-KKGEDDKLILCDECNKAFHLFCLRP 1216
+ + LL L ++ K+C +K +I C+ C AFH C+
Sbjct: 1157 QSLRLANEGKLLSPL----------QDVDIKICLCQKAPAAPMIQCELCRDAFHTSCV-- 1204
Query: 1217 ALYEVPDG--EWQCPACQ 1232
A+ + G W CP C+
Sbjct: 1205 AVPSISQGLRIWLCPHCR 1222
>gi|169218173 PREDICTED: similar to Jumonji, AT rich interactive
domain 1B (RBP2-like), partial [Homo sapiens]
Length = 977
Score = 66.6 bits (161), Expect = 2e-10
Identities = 44/157 (28%), Positives = 76/157 (48%), Gaps = 32/157 (20%)
Query: 1111 GFMAPKQKRRKLQSEDSAKTEEVDEEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLG 1170
G PK + K + + S K E ++ + +VE K EK K+ ++A ++V
Sbjct: 261 GCPTPKCENEK-EMKSSIKQEPIERKDYIVENEK-----EKPKSRSKKATNAVDLYV--- 311
Query: 1171 MLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPA 1230
C +C ++D+L+LCD C+ ++H FCL P L++VP G+W+CP
Sbjct: 312 ----------------CLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPK 355
Query: 1231 C--QPATARRNSRG-----RNYTEESASEDSEDDESD 1260
C Q + + + G R+YT + E ++ +SD
Sbjct: 356 CLAQECSKPQEAFGFEQAARDYTLRTFGEMADAFKSD 392
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 66.6 bits (161), Expect = 2e-10
Identities = 34/85 (40%), Positives = 51/85 (60%), Gaps = 4/85 (4%)
Query: 1338 SRRQSLELQ----KCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVITHPMDFQTVQNKC 1393
+R QS ++Q +CEE+L+ I + S PFR+PV E DY D+I PMDF TV+
Sbjct: 1311 NRAQSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETL 1370
Query: 1394 SCGSYRSVQEFLTDMKQVFTNAEVY 1418
G+Y S E D++ +F+N++ Y
Sbjct: 1371 EAGNYESPMELCKDVRLIFSNSKAY 1395
Score = 36.2 bits (82), Expect = 0.24
Identities = 36/171 (21%), Positives = 71/171 (41%), Gaps = 17/171 (9%)
Query: 1321 PVDDAEVDELVLQTKRSSRRQSLELQKCEEI---LHKIVKYRFSWPFREPVTRDEAEDYY 1377
P+ D E L+ + + ++CE I +++++ + F PV Y
Sbjct: 1138 PLTDGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDLQAYPMYC 1197
Query: 1378 DVITHPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLV 1437
V+ +P D T++ + YR V + +++ + N +N GS + VK+ + +
Sbjct: 1198 TVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPI----VKSAKFVT 1253
Query: 1438 ALLHKHLPGHP-------YVRRKRKKFPDRLAEDEGDSEPEAVGQSRGRRQ 1481
LL + Y K+K D +EDE + + + G S +R+
Sbjct: 1254 DLLLHFIKDQTCYNIIPLYNSMKKKVLSD--SEDE-EKDADVPGTSTRKRK 1301
Score = 31.2 bits (69), Expect = 7.8
Identities = 26/86 (30%), Positives = 45/86 (52%), Gaps = 14/86 (16%)
Query: 530 EHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKER------REKEMLERLEKQKRYEDQ 583
++K + A S ++ +E K+K++++KK+ K+ +E+ ++K+ ER KQKR
Sbjct: 871 KNKTKKAESSSDEEEESEKQKQKQIKKEKKKVNEEKDGPISPKKKKPKER--KQKRLAVG 928
Query: 584 ELTGKNLPAFRLVDTPEGLPNTLFGD 609
ELT L E LP+T D
Sbjct: 929 ELTENGL------TLEEWLPSTWITD 948
>gi|38788260 bromodomain PHD finger transcription factor isoform 2
[Homo sapiens]
Length = 2903
Score = 66.2 bits (160), Expect = 2e-10
Identities = 31/92 (33%), Positives = 46/92 (50%)
Query: 1349 EEILHKIVKYRFSWPFREPVTRDEAEDYYDVITHPMDFQTVQNKCSCGSYRSVQEFLTDM 1408
+ +L + ++ +WPF EPV ++A DYY VI PMD T++ + Y + EF+ DM
Sbjct: 2794 KRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADM 2853
Query: 1409 KQVFTNAEVYNCRGSHVLSCMVKTEQCLVALL 1440
++F N YN S C E V L
Sbjct: 2854 TKIFDNCRYYNPSDSPFYQCAEVLESFFVQKL 2885
Score = 55.5 bits (132), Expect = 4e-07
Identities = 21/45 (46%), Positives = 30/45 (66%), Gaps = 3/45 (6%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPAC 1231
C+VC K G+ L+ C+ C+ +HL C++P L EVP+ EWQC C
Sbjct: 393 CRVCHKLGD---LLCCETCSAVYHLECVKPPLEEVPEDEWQCEVC 434
Score = 34.7 bits (78), Expect = 0.70
Identities = 61/322 (18%), Positives = 123/322 (38%), Gaps = 51/322 (15%)
Query: 264 AGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRKNTGSPDRKPSKKSKT 323
AGTGE + ++ D L P + ++ P+ + T P +P +++
Sbjct: 2359 AGTGEQRQSKLSPQM-------QVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQP 2411
Query: 324 DNSSLSSPLNPKLWCHVHLKKSLSGS--------PLKVKNSKNSKSPEEHLEEMMKMMSP 375
SP P++ ++ + S P ++SK + + + ++ SP
Sbjct: 2412 Q-----SPAQPEVQTQPEVQTQTTVSSHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSP 2466
Query: 376 NKLHT--NFHIPKKGPPAKKPGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKT 433
++ + I P PG+ S S+ I ++ S + P+
Sbjct: 2467 VRVQSPSQTRIRPSTPSQLSPGQQSQVQTTT---SQPIPIQPHTSLQIPSQGQPQSQPQV 2523
Query: 434 KMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYKENKDREDKRS 493
MK +++ K + MT A R ++ K++ L KE K KR
Sbjct: 2524 VMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYI------LDKIDKEEKQAAKKRK 2577
Query: 494 ALSCVISKTARLLSSEDRARL---PEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKK 550
V K ++ +++ A L E+LR+ + K+ LL+ K
Sbjct: 2578 REESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLD-----------------KDL 2620
Query: 551 REELKKKLKEKAKERREKEMLE 572
+ E++++LK K ++EK++++
Sbjct: 2621 QIEVQEELKRDLKIKKEKDLMQ 2642
Score = 33.5 bits (75), Expect = 1.6
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 1238 RNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEED 1274
R + R + +D E +E +EEE+ EEEEEED
Sbjct: 113 RTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEED 149
Score = 33.5 bits (75), Expect = 1.6
Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 15/84 (17%)
Query: 1251 SEDSEDDESDEEEEEEEE----EEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPG 1306
++DSEDDE DE EE++++ EE E+D + A +S P GRR
Sbjct: 155 TQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTP-----GRR-- 207
Query: 1307 KKPHSTRRSQPKAPPVDDAEVDEL 1330
KP R +P++P +++ ++ L
Sbjct: 208 -KP---RVHRPRSPILEEKDIPPL 227
Score = 32.7 bits (73), Expect = 2.7
Identities = 11/30 (36%), Positives = 22/30 (73%)
Query: 1247 EESASEDSEDDESDEEEEEEEEEEEEEDYE 1276
E+ SE+ E+++ D EE ++ E++EE++ E
Sbjct: 138 EDMVSEEEEEEDGDAEETQDSEDDEEDEME 167
Score = 32.7 bits (73), Expect = 2.7
Identities = 12/29 (41%), Positives = 21/29 (72%)
Query: 1246 TEESASEDSEDDESDEEEEEEEEEEEEED 1274
+EE ED + +E+ + E++EE+E EE+D
Sbjct: 142 SEEEEEEDGDAEETQDSEDDEEDEMEEDD 170
Score = 32.3 bits (72), Expect = 3.5
Identities = 17/45 (37%), Positives = 28/45 (62%), Gaps = 3/45 (6%)
Query: 1235 TARRNSRGRNYTEESASEDSEDDE---SDEEEEEEEEEEEEEDYE 1276
TA R + + ++ SE+ E++E S+EEEEE+ + EE +D E
Sbjct: 115 TAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSE 159
Score = 31.6 bits (70), Expect = 6.0
Identities = 11/29 (37%), Positives = 18/29 (62%)
Query: 1247 EESASEDSEDDESDEEEEEEEEEEEEEDY 1275
EE + D D+EE+E EE++++ DY
Sbjct: 147 EEDGDAEETQDSEDDEEDEMEEDDDDSDY 175
Score = 31.6 bits (70), Expect = 6.0
Identities = 18/68 (26%), Positives = 37/68 (54%), Gaps = 9/68 (13%)
Query: 515 PEELRSLVQKRYELLEHKKRWASMSEEQRKE---------YLKKKREELKKKLKEKAKER 565
P+ +V K ++EH K+ SM+ +R+E +K +++ K+ K+ AK+R
Sbjct: 2517 PQSQPQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKR 2576
Query: 566 REKEMLER 573
+ +E +E+
Sbjct: 2577 KREESVEQ 2584
>gi|38788274 bromodomain PHD finger transcription factor isoform 1
[Homo sapiens]
Length = 2920
Score = 66.2 bits (160), Expect = 2e-10
Identities = 31/92 (33%), Positives = 46/92 (50%)
Query: 1349 EEILHKIVKYRFSWPFREPVTRDEAEDYYDVITHPMDFQTVQNKCSCGSYRSVQEFLTDM 1408
+ +L + ++ +WPF EPV ++A DYY VI PMD T++ + Y + EF+ DM
Sbjct: 2811 KRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADM 2870
Query: 1409 KQVFTNAEVYNCRGSHVLSCMVKTEQCLVALL 1440
++F N YN S C E V L
Sbjct: 2871 TKIFDNCRYYNPSDSPFYQCAEVLESFFVQKL 2902
Score = 55.5 bits (132), Expect = 4e-07
Identities = 21/45 (46%), Positives = 30/45 (66%), Gaps = 3/45 (6%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPAC 1231
C+VC K G+ L+ C+ C+ +HL C++P L EVP+ EWQC C
Sbjct: 393 CRVCHKLGD---LLCCETCSAVYHLECVKPPLEEVPEDEWQCEVC 434
Score = 37.4 bits (85), Expect = 0.11
Identities = 47/253 (18%), Positives = 105/253 (41%), Gaps = 43/253 (16%)
Query: 356 SKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGRSKGILNGQ 415
S+ S + ++ P + HT+ IP +G P +P S + G++ LN Q
Sbjct: 2357 SQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVQSSTQTLSSGQT---LN-Q 2412
Query: 416 KSTGNSKSPKKGLKTPKTKM-------KQMTLLDMAKGTQKMTRAPRNSGGTPRT----- 463
+ + P+ ++ P+ ++ +Q+ +L + +Q + + G P+
Sbjct: 2413 VTVSSPSRPQLQIQQPQPQVIAVPQLQQQVQVLSQIQ-SQVVAQIQAQQSGVPQQIKLQL 2471
Query: 464 ------SSKPHKHL--------PPAALHLIAYYKENKDREDKRSALSCVISKTARLLSSE 509
SS H + + ++ +D++ K+ I + L +S
Sbjct: 2472 PIQIQQSSAVQTHQIQNVVTVQAASVQEQLQRVQQLRDQQQKKKQQQIEIKREHTLQASN 2531
Query: 510 DRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKE---------YLKKKREELKKKLKE 560
+ +++ V K ++EH K+ SM+ +R+E +K +++ K+ K+
Sbjct: 2532 QSEIIQKQV---VMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQ 2588
Query: 561 KAKERREKEMLER 573
AK+R+ +E +E+
Sbjct: 2589 AAKKRKREESVEQ 2601
Score = 33.5 bits (75), Expect = 1.6
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 1238 RNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEED 1274
R + R + +D E +E +EEE+ EEEEEED
Sbjct: 113 RTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEED 149
Score = 33.5 bits (75), Expect = 1.6
Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 15/84 (17%)
Query: 1251 SEDSEDDESDEEEEEEEE----EEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPG 1306
++DSEDDE DE EE++++ EE E+D + A +S P GRR
Sbjct: 155 TQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTP-----GRR-- 207
Query: 1307 KKPHSTRRSQPKAPPVDDAEVDEL 1330
KP R +P++P +++ ++ L
Sbjct: 208 -KP---RVHRPRSPILEEKDIPPL 227
Score = 32.7 bits (73), Expect = 2.7
Identities = 11/30 (36%), Positives = 22/30 (73%)
Query: 1247 EESASEDSEDDESDEEEEEEEEEEEEEDYE 1276
E+ SE+ E+++ D EE ++ E++EE++ E
Sbjct: 138 EDMVSEEEEEEDGDAEETQDSEDDEEDEME 167
Score = 32.7 bits (73), Expect = 2.7
Identities = 12/29 (41%), Positives = 21/29 (72%)
Query: 1246 TEESASEDSEDDESDEEEEEEEEEEEEED 1274
+EE ED + +E+ + E++EE+E EE+D
Sbjct: 142 SEEEEEEDGDAEETQDSEDDEEDEMEEDD 170
Score = 32.3 bits (72), Expect = 3.5
Identities = 17/45 (37%), Positives = 28/45 (62%), Gaps = 3/45 (6%)
Query: 1235 TARRNSRGRNYTEESASEDSEDDE---SDEEEEEEEEEEEEEDYE 1276
TA R + + ++ SE+ E++E S+EEEEE+ + EE +D E
Sbjct: 115 TAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSE 159
Score = 31.6 bits (70), Expect = 6.0
Identities = 11/29 (37%), Positives = 18/29 (62%)
Query: 1247 EESASEDSEDDESDEEEEEEEEEEEEEDY 1275
EE + D D+EE+E EE++++ DY
Sbjct: 147 EEDGDAEETQDSEDDEEDEMEEDDDDSDY 175
>gi|110618244 retinoblastoma binding protein 2 isoform 1 [Homo
sapiens]
Length = 1690
Score = 66.2 bits (160), Expect = 2e-10
Identities = 31/81 (38%), Positives = 48/81 (59%), Gaps = 7/81 (8%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPAC--QPATARRNSRG-- 1242
C C + +DKL+LCD C+ ++H FCL P L +VP G+W+CP C + + R + G
Sbjct: 296 CMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFE 355
Query: 1243 ---RNYTEESASEDSEDDESD 1260
R YT +S E +++ +SD
Sbjct: 356 QAVREYTLQSFGEMADNFKSD 376
>gi|110618242 retinoblastoma binding protein 2 isoform 2 [Homo
sapiens]
Length = 1641
Score = 66.2 bits (160), Expect = 2e-10
Identities = 31/81 (38%), Positives = 48/81 (59%), Gaps = 7/81 (8%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPAC--QPATARRNSRG-- 1242
C C + +DKL+LCD C+ ++H FCL P L +VP G+W+CP C + + R + G
Sbjct: 296 CMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFE 355
Query: 1243 ---RNYTEESASEDSEDDESD 1260
R YT +S E +++ +SD
Sbjct: 356 QAVREYTLQSFGEMADNFKSD 376
>gi|226443002 jumonji, AT rich interactive domain 1D isoform 3 [Homo
sapiens]
Length = 1482
Score = 66.2 bits (160), Expect = 2e-10
Identities = 30/81 (37%), Positives = 46/81 (56%), Gaps = 7/81 (8%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARR-------N 1239
C+VC + EDDKL+ CD C+ +H+FCL P L E+P G W+CP C A ++
Sbjct: 260 CQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFE 319
Query: 1240 SRGRNYTEESASEDSEDDESD 1260
+ Y+ +S E ++ +SD
Sbjct: 320 QATQEYSLQSFGEMADSFKSD 340
>gi|33356560 jumonji, AT rich interactive domain 1D isoform 2 [Homo
sapiens]
Length = 1539
Score = 66.2 bits (160), Expect = 2e-10
Identities = 30/81 (37%), Positives = 46/81 (56%), Gaps = 7/81 (8%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARR-------N 1239
C+VC + EDDKL+ CD C+ +H+FCL P L E+P G W+CP C A ++
Sbjct: 317 CQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFE 376
Query: 1240 SRGRNYTEESASEDSEDDESD 1260
+ Y+ +S E ++ +SD
Sbjct: 377 QATQEYSLQSFGEMADSFKSD 397
>gi|226442991 jumonji, AT rich interactive domain 1D isoform 1 [Homo
sapiens]
Length = 1570
Score = 66.2 bits (160), Expect = 2e-10
Identities = 30/81 (37%), Positives = 46/81 (56%), Gaps = 7/81 (8%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARR-------N 1239
C+VC + EDDKL+ CD C+ +H+FCL P L E+P G W+CP C A ++
Sbjct: 317 CQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFE 376
Query: 1240 SRGRNYTEESASEDSEDDESD 1260
+ Y+ +S E ++ +SD
Sbjct: 377 QATQEYSLQSFGEMADSFKSD 397
>gi|51599156 chromodomain helicase DNA binding protein 4 [Homo
sapiens]
Length = 1912
Score = 65.1 bits (157), Expect = 5e-10
Identities = 33/99 (33%), Positives = 56/99 (56%), Gaps = 20/99 (20%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYT 1246
C+VC++ GE +ILCD C +A+H+ CL P + + P+G+W CP C+
Sbjct: 373 CEVCQQGGE---IILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCE-------------- 415
Query: 1247 EESASEDSEDDESDEEEEEEE---EEEEEEDYEVAGLRL 1282
+E ++++D S+ EE EE + EEE+D+ + R+
Sbjct: 416 KEGIQWEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRV 454
Score = 58.2 bits (139), Expect = 6e-08
Identities = 22/45 (48%), Positives = 30/45 (66%), Gaps = 3/45 (6%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPAC 1231
C+VC+ GE L+ CD C ++H+ CL P L E+P+GEW CP C
Sbjct: 452 CRVCKDGGE---LLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRC 493
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 64.7 bits (156), Expect = 6e-10
Identities = 22/50 (44%), Positives = 34/50 (68%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATA 1236
C+ CRK G D K+++C+ C+K +H FCL+P + E+P W+C AC+ A
Sbjct: 276 CQACRKPGNDSKMLVCETCDKGYHTFCLKPPMEELPAHSWKCKACRVCRA 325
Score = 55.1 bits (131), Expect = 5e-07
Identities = 19/45 (42%), Positives = 30/45 (66%)
Query: 1187 CKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPAC 1231
C+VC + + +L+LCD+C+ ++H +CL P L VP G W+C C
Sbjct: 1430 CEVCGQASDPSRLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWC 1474
Score = 46.6 bits (109), Expect = 2e-04
Identities = 23/56 (41%), Positives = 25/56 (44%)
Query: 1183 ENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARR 1238
E ARC VC GE L C C +H CL AL WQCP C+ A R
Sbjct: 225 EEARCAVCEGPGELCDLFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACR 280
Score = 31.2 bits (69), Expect = 7.8
Identities = 13/48 (27%), Positives = 26/48 (54%), Gaps = 3/48 (6%)
Query: 1187 CKVCRK--KGEDDKLILCDECNKAFHLFCLRPALYEVPDGE-WQCPAC 1231
C VC +G + L+ C +C++ +H +C+ + +V + W+C C
Sbjct: 1380 CVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVEC 1427
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,557,493
Number of Sequences: 37866
Number of extensions: 3078815
Number of successful extensions: 56476
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 755
Number of HSP's successfully gapped in prelim test: 795
Number of HSP's that attempted gapping in prelim test: 25285
Number of HSP's gapped (non-prelim): 20114
length of query: 1483
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1368
effective length of database: 13,892,928
effective search space: 19005525504
effective search space used: 19005525504
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.