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Search of human proteins with 146231950
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|146231950 dehydrogenase/reductase (SDR family) member 13
[Homo sapiens]
(377 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom... 756 0.0
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 244 7e-65
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 242 3e-64
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo... 236 3e-62
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 233 3e-61
gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens] 176 4e-44
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s... 163 3e-40
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo... 138 7e-33
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 62 6e-10
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 60 2e-09
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 59 5e-09
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho... 59 9e-09
gi|4502599 carbonyl reductase 1 [Homo sapiens] 58 2e-08
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 58 2e-08
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 58 2e-08
gi|4502601 carbonyl reductase 3 [Homo sapiens] 57 2e-08
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 55 1e-07
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 55 1e-07
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho... 54 2e-07
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 54 2e-07
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo... 54 3e-07
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 54 3e-07
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 53 4e-07
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo... 52 7e-07
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ... 52 7e-07
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 52 1e-06
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens] 52 1e-06
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 51 1e-06
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 51 1e-06
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 51 1e-06
>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
sapiens]
Length = 377
Score = 756 bits (1953), Expect = 0.0
Identities = 377/377 (100%), Positives = 377/377 (100%)
Query: 1 MEALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRG 60
MEALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRG
Sbjct: 1 MEALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRG 60
Query: 61 ARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILI 120
ARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILI
Sbjct: 61 ARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILI 120
Query: 121 HNAGISSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDF 180
HNAGISSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDF
Sbjct: 121 HNAGISSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDF 180
Query: 181 KRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLRHVP 240
KRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLRHVP
Sbjct: 181 KRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLRHVP 240
Query: 241 GWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAA 300
GWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAA
Sbjct: 241 GWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAA 300
Query: 301 HRLWEASKRLAGLGPGEDAEPDEDPQSEDSEAPSSLSTPHPEEPTVSQPYPSPQSSPDLS 360
HRLWEASKRLAGLGPGEDAEPDEDPQSEDSEAPSSLSTPHPEEPTVSQPYPSPQSSPDLS
Sbjct: 301 HRLWEASKRLAGLGPGEDAEPDEDPQSEDSEAPSSLSTPHPEEPTVSQPYPSPQSSPDLS 360
Query: 361 KMTHRIQAKVEPEIQLS 377
KMTHRIQAKVEPEIQLS
Sbjct: 361 KMTHRIQAKVEPEIQLS 377
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 244 bits (624), Expect = 7e-65
Identities = 139/291 (47%), Positives = 185/291 (63%), Gaps = 13/291 (4%)
Query: 28 CGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNN 87
C L G+ VVTGAN+GIGK TA ELA+RGARV LACR E+GE A +++ +GN
Sbjct: 33 CTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQ 92
Query: 88 EVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAGISSC--GRTREAFNLLLRVNHIG 145
+V+ LDL+ S+RAFA FL+ E L +LI+NAG+ C +T + F + + VNH+G
Sbjct: 93 QVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLG 152
Query: 146 PFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANV 205
FLLTHLLL LK APSR+V V+S AH GR+ F L + AY +KLAN+
Sbjct: 153 HFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGE--KFYNAGLAYCHSKLANI 210
Query: 206 LFARELANQLEATGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWL---VLRAPRGGA 262
LF +ELA +L+ +GVT Y+ HPG V SEL +RH +R + WL ++ P+ GA
Sbjct: 211 LFTQELARRLKGSGVTTYSVHPGTVQSEL-VRH-----SSFMRWMWWLFSFFIKTPQQGA 264
Query: 263 QTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRLAGL 313
QT L+CAL EG+E LSG +F++CHV V AR++ A RLW+ S L GL
Sbjct: 265 QTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDLLGL 315
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 242 bits (618), Expect = 3e-64
Identities = 143/287 (49%), Positives = 186/287 (64%), Gaps = 17/287 (5%)
Query: 34 LRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMA 93
L G+ V+TGAN+GIGK TA ELA RGARV +ACR +GE+AA ++R ++ N++V+
Sbjct: 37 LPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRK 96
Query: 94 LDLASLASVRAFATAFLSSEPRLDILIHNAGISSC--GRTREAFNLLLRVNHIGPFLLTH 151
LDL+ S+RAFA FL+ E +L ILI+NAG+ C +T + F L VNH+G FLLT+
Sbjct: 97 LDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTY 156
Query: 152 LLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELR-----AYADTKLANVL 206
LLL LK AP+RVV V+S AH G++ F L + E R AY +KLANVL
Sbjct: 157 LLLERLKVSAPARVVNVSSVAHHIGKIPFHDL-------QSEKRYSRGFAYCHSKLANVL 209
Query: 207 FARELANQLEATGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPL 266
F RELA +L+ TGVT YA HPG V SEL +RH L LL L ++ R GAQT L
Sbjct: 210 FTRELAKRLQGTGVTTYAVHPGVVRSEL-VRH--SSLLCLLWRLFSPFVKTAREGAQTSL 266
Query: 267 YCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRLAGL 313
+CAL EG+EPLSG+YF++C V P AR+++ A RLW S L G+
Sbjct: 267 HCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGI 313
>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
sapiens]
Length = 336
Score = 236 bits (601), Expect = 3e-62
Identities = 140/324 (43%), Positives = 189/324 (58%), Gaps = 18/324 (5%)
Query: 6 LGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVVL 65
LG L L A V + + G G + G+T ++TGANSG+G+ TA EL R GARV++
Sbjct: 13 LGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARVIM 72
Query: 66 ACRSQERGEAAAFDLRQE-------------SGNNEVIFMALDLASLASVRAFATAFLSS 112
CR + R E AA LR+E SG E+I LDLASL SVRAF L
Sbjct: 73 GCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQE 132
Query: 113 EPRLDILIHNAGISSCG--RTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVAS 170
EPRLD+LI+NAGI C +T + F + VNH+G FLLT+LLL LK+ APSR+VVV+S
Sbjct: 133 EPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSS 192
Query: 171 AAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPV 230
+ G ++F L+ + Y+ +KLAN+LF RELA +LE T VT HPG V
Sbjct: 193 KLYKYGDINFDDLNSEQS--YNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIV 250
Query: 231 NSELFLR-HVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEE 289
+ L H+P ++PL ++W + P GAQT +Y A +E +SGRYF +C EE
Sbjct: 251 RTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSGRYFGDCKEEE 310
Query: 290 VPPAARDDRAAHRLWEASKRLAGL 313
+ P A D+ A +LW+ S+ + GL
Sbjct: 311 LLPKAMDESVARKLWDISEVMVGL 334
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 233 bits (593), Expect = 3e-61
Identities = 136/314 (43%), Positives = 185/314 (58%), Gaps = 7/314 (2%)
Query: 5 LLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVV 64
L G + GA VL+ + V C + G+T +VTGAN+GIGK TALELARRG ++
Sbjct: 8 LSALGTVAGAAVLLK-DYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNII 66
Query: 65 LACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAG 124
LACR E+ EAAA D+R E+ N+ V LDLASL S+R FA + E R+DILI+NAG
Sbjct: 67 LACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAG 126
Query: 125 ISSCGR--TREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKR 182
+ C T + F + VNH+G FLLT+LLL LKA APSR++ ++S AH G +DF
Sbjct: 127 VMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDD 186
Query: 183 LDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLR---HV 239
L+ + + AY +KLA VLF +EL+ +L+ +GVT A HPG +EL H
Sbjct: 187 LNWQTRKYNTK-AAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHG 245
Query: 240 PGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRA 299
+ L P+ WL++++P AQ Y A+ E + +SG+YF + P A D+
Sbjct: 246 STFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEV 305
Query: 300 AHRLWEASKRLAGL 313
A RLW S RL GL
Sbjct: 306 ARRLWAESARLVGL 319
>gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens]
Length = 260
Score = 176 bits (445), Expect = 4e-44
Identities = 104/248 (41%), Positives = 144/248 (58%), Gaps = 6/248 (2%)
Query: 71 ERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAGISSCGR 130
E+ EAAA D+R E+ N+ V LDLASL S+R FA + E R+DILI+NAG+ C
Sbjct: 2 EKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPH 61
Query: 131 --TREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVV 188
T + F + VNH+G FLLT+LLL LKA APSR++ ++S AH G +DF L+
Sbjct: 62 WTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTR 121
Query: 189 GWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLR---HVPGWLRP 245
+ + AY +KLA VLF +EL+ +L+ +GVT A HPG +EL H +
Sbjct: 122 KYNTK-AAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSST 180
Query: 246 LLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWE 305
L P+ WL++++P AQ Y A+ E + +SG+YF + P A D+ A RLW
Sbjct: 181 TLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWA 240
Query: 306 ASKRLAGL 313
S RL GL
Sbjct: 241 ESARLVGL 248
>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
sapiens]
Length = 414
Score = 163 bits (412), Expect = 3e-40
Identities = 111/284 (39%), Positives = 145/284 (51%), Gaps = 12/284 (4%)
Query: 36 GRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALD 95
G+ VVTGANSGIG TA A GA V+LACR+ R A + +E +V M LD
Sbjct: 124 GKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLD 183
Query: 96 LASLASVRAFATAFLSSEPRLDILIHNAGISSC--GRTREAFNLLLRVNHIGPFLLTHLL 153
LA L SV+ FA AF + L +L+ NA + T++ +VNH+G F L LL
Sbjct: 184 LALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLL 243
Query: 154 LPCLKACAPSRVVVVASAAH-------CRGRLDFKRLDRPVVGWRQELRAYADTKLANVL 206
L AP+RV+VV+S +H G+LDF RL P + AY +KL N+L
Sbjct: 244 QDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLS-PTKNDYWAMLAYNRSKLCNIL 302
Query: 207 FARELANQLEATGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPL 266
F+ EL +L GVT A HPG N H W+ LL LA ++ + GA T +
Sbjct: 303 FSNELHRRLSPRGVTSNAVHPG--NMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTV 360
Query: 267 YCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRL 310
YCA +E L G YF NC P A+ + A LW S+RL
Sbjct: 361 YCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERL 404
>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
sapiens]
Length = 330
Score = 138 bits (348), Expect = 7e-33
Identities = 96/285 (33%), Positives = 143/285 (50%), Gaps = 11/285 (3%)
Query: 37 RTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDL 96
R A+VTG GIG TA LAR G V++A + + + +++E+ N++V F+ DL
Sbjct: 44 RVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDL 103
Query: 97 ASLASVRAFATAFLSSEPRLDILIHNAGISSC--GRTREAFNLLLRVNHIGPFLLTHLLL 154
AS+ S+R F F + L +LI+NAG+ +TR+ F +N++G FLLT+LLL
Sbjct: 104 ASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLL 163
Query: 155 PCLKACA----PSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARE 210
LK +RVV V+SA H L+ L AYA +KLA VLF
Sbjct: 164 DTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSAC--YSPHAAYAQSKLALVLFTYH 221
Query: 211 LANQLEATG--VTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYC 268
L L A G VT PG VN++++ +HV R + L WL+ + P GA T +Y
Sbjct: 222 LQRLLAAEGSHVTANVVDPGVVNTDVY-KHVFWATRLAKKLLGWLLFKTPDEGAWTSIYA 280
Query: 269 ALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRLAGL 313
A+ +E + G Y N + + + +LW S + G+
Sbjct: 281 AVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGV 325
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 62.4 bits (150), Expect = 6e-10
Identities = 57/234 (24%), Positives = 104/234 (44%), Gaps = 28/234 (11%)
Query: 4 LLLGAGLLLGAYVLVYYN---LVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRG 60
+LL A L A+VL+ Y L+ P L G VVTG +SGIGK A+E ++G
Sbjct: 1 MLLLAAAFLVAFVLLLYMVSPLISPKPLA----LPGAHVVVTGGSSGIGKCIAIECYKQG 56
Query: 61 ARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRL---D 117
A + L R++++ A ++ S N++ + + + + ++ +L D
Sbjct: 57 AFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVD 116
Query: 118 ILIHNAGISSCGRTRE----AFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAH 173
+L++ AG++ G+ + F L+ +N++G + ++ +K R+V V+S A
Sbjct: 117 MLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAG 176
Query: 174 CRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHP 227
G F AY+ +K A A L +++ V A+P
Sbjct: 177 QLGLFGF--------------TAYSASKFAIRGLAEALQMEVKPYNVYITVAYP 216
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 60.5 bits (145), Expect = 2e-09
Identities = 57/213 (26%), Positives = 91/213 (42%), Gaps = 22/213 (10%)
Query: 30 GMGNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESG---- 85
G LR V+TGA SG+GK A GA++VL R+ E +L
Sbjct: 46 GKAYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQ 105
Query: 86 NNEVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAGISSCG----RTREAFNLLLRV 141
++ + DL ++ A A L +DIL++NAGIS G T + ++
Sbjct: 106 THKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMET 165
Query: 142 NHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTK 201
N+ GP LT LLP + +V ++S +G++ + +R AYA +K
Sbjct: 166 NYFGPVALTKALLPSMIKRRQGHIVAISS---IQGKMS--------IPFRS---AYAASK 211
Query: 202 LANVLFARELANQLEATGVTCYAAHPGPVNSEL 234
A F L ++E + PG +++ L
Sbjct: 212 HATQAFFDCLRAEMEQYEIEVTVISPGYIHTNL 244
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 59.3 bits (142), Expect = 5e-09
Identities = 44/137 (32%), Positives = 70/137 (51%), Gaps = 8/137 (5%)
Query: 41 VTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGN---NEVIFMALDLA 97
VTGA+SGIG+ A +L++ G +VL+ R E E+GN +++ + LDL
Sbjct: 55 VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRC-LENGNLKEKDILVLPLDLT 113
Query: 98 SLASVRAFATAFLSSEPRLDILIHNAGISS---CGRTR-EAFNLLLRVNHIGPFLLTHLL 153
S A A L R+DIL++N G+S C T + + L+ +N++G LT +
Sbjct: 114 DTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCV 173
Query: 154 LPCLKACAPSRVVVVAS 170
LP + ++V V S
Sbjct: 174 LPHMIERKQGKIVTVNS 190
>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
sapiens]
Length = 286
Score = 58.5 bits (140), Expect = 9e-09
Identities = 69/242 (28%), Positives = 104/242 (42%), Gaps = 21/242 (8%)
Query: 1 MEALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRG 60
M+ LLL LGA YY P +L+G ++TGAN+G+G+ A AR G
Sbjct: 1 MKVLLLTG---LGALFFAYYWDDNFDPA----SLQGARVLLTGANAGVGEELAYHYARLG 53
Query: 61 ARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILI 120
+ +VL ++ + + R + G +V ++A D+AS + + L LD L+
Sbjct: 54 SHLVLTAHTEALLQKVVGNCR-KLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLV 112
Query: 121 HN----AGISSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRG 176
N A + R+ +A L++VN + LT LP L S VVV +
Sbjct: 113 LNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPT 172
Query: 177 RLD--FKRLDRPVVGWRQELRAYADTKLAN------VLFARELANQLEAT-GVTCYAAHP 227
+ + G+ LR D + N VL R+ A+ EA GVT A P
Sbjct: 173 SFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAP 232
Query: 228 GP 229
GP
Sbjct: 233 GP 234
>gi|4502599 carbonyl reductase 1 [Homo sapiens]
Length = 277
Score = 57.8 bits (138), Expect = 2e-08
Identities = 77/289 (26%), Positives = 113/289 (39%), Gaps = 58/289 (20%)
Query: 39 AVVTGANSGIGKMTALELARR-GARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLA 97
A+VTG N GIG +L R VVL R RG+AA L+ E + F LD+
Sbjct: 8 ALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPR--FHQLDID 65
Query: 98 SLASVRAFATAFLSSEPRLDILIHNAGISSCGRTREAFNL----LLRVNHIGPFLLTHLL 153
L S+RA LD+L++NAGI+ F++ ++ N G + L
Sbjct: 66 DLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTEL 125
Query: 154 LP------------------CLKACAPSRVVVVASAAHCRGRL---------DFKRLDRP 186
LP LK+C+P S L D K+
Sbjct: 126 LPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQ 185
Query: 187 VVGWRQELRAYADTKLA----NVLFARELANQLEATGVTCYAAHPGPVNSELFLRHVPGW 242
GW AY TK+ + + AR+L+ Q + + A PGW
Sbjct: 186 KEGWPSS--AYGVTKIGVTVLSRIHARKLSEQRKGDKILLNAC-------------CPGW 230
Query: 243 LRP-LLRPLAWLVLRAPRGGAQTPLYCA-LQEGIEPLSGRYFANCHVEE 289
+R + P A ++P GA+TP+Y A L E G++ + VE+
Sbjct: 231 VRTDMAGPKA---TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQ 276
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 57.8 bits (138), Expect = 2e-08
Identities = 58/207 (28%), Positives = 90/207 (43%), Gaps = 22/207 (10%)
Query: 32 GNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIF 91
G L R AVVTG+ SGIG A LAR GA VV++ R Q+ + A L+ E V
Sbjct: 32 GVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGE--GLSVAG 89
Query: 92 MALDLASLASVRAFATAFLSSEPRLDILIHNAGI-----SSCGRTREAFNLLLRVNHIGP 146
+ + L +D L+ +AG+ S+ G + + ++ +L VN P
Sbjct: 90 IVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSP 149
Query: 147 FLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVL 206
LL LLP ++ + ++V + AA+ PVV L Y +K A +
Sbjct: 150 ALLLSQLLPYMENRRGAVILVSSIAAY-----------NPVVA----LGVYNVSKTALLG 194
Query: 207 FARELANQLEATGVTCYAAHPGPVNSE 233
R LA +L + PG + ++
Sbjct: 195 LTRTLALELAPKDIRVNCVVPGIIKTD 221
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 57.8 bits (138), Expect = 2e-08
Identities = 58/207 (28%), Positives = 90/207 (43%), Gaps = 22/207 (10%)
Query: 32 GNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIF 91
G L R AVVTG+ SGIG A LAR GA VV++ R Q+ + A L+ E V
Sbjct: 32 GVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGE--GLSVAG 89
Query: 92 MALDLASLASVRAFATAFLSSEPRLDILIHNAGI-----SSCGRTREAFNLLLRVNHIGP 146
+ + L +D L+ +AG+ S+ G + + ++ +L VN P
Sbjct: 90 IVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSP 149
Query: 147 FLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVL 206
LL LLP ++ + ++V + AA+ PVV L Y +K A +
Sbjct: 150 ALLLSQLLPYMENRRGAVILVSSIAAY-----------NPVVA----LGVYNVSKTALLG 194
Query: 207 FARELANQLEATGVTCYAAHPGPVNSE 233
R LA +L + PG + ++
Sbjct: 195 LTRTLALELAPKDIRVNCVVPGIIKTD 221
>gi|4502601 carbonyl reductase 3 [Homo sapiens]
Length = 277
Score = 57.4 bits (137), Expect = 2e-08
Identities = 74/273 (27%), Positives = 107/273 (39%), Gaps = 61/273 (22%)
Query: 37 RTAVVTGANSGIGKMTALELARR-GARVVLACRSQERGEAAAFDLRQESGNNEVIFMALD 95
R A+VTGAN GIG A EL R+ VVL R RG+AA L+ E + F LD
Sbjct: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPR--FHQLD 63
Query: 96 LASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTREAFN----LLLRVNHIGPFLLTH 151
+ L S+RA L++L++NA ++ F+ + L+ N + +
Sbjct: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123
Query: 152 LLLPCLKACAPSRVVVVASAAHC---------------------RGRL---------DFK 181
LLP +K P VV S+ C G L D K
Sbjct: 124 ELLPIMK---PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180
Query: 182 RLDRPVVGWRQELRAYADTKLANVLFARELANQLE----ATGVTCYAAHPGPVNSELFLR 237
GW Y +KL + +R LA +L+ A + A PGPV +++ +
Sbjct: 181 NEVHEREGWPNS--PYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238
Query: 238 HVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCAL 270
+R GA+TP+Y AL
Sbjct: 239 D---------------SIRTVEEGAETPVYLAL 256
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 55.1 bits (131), Expect = 1e-07
Identities = 54/194 (27%), Positives = 89/194 (45%), Gaps = 25/194 (12%)
Query: 1 MEALLLGAGLL--LGAYVLVY------YNLVKAPPCGGMGNLRG------RTAVVTGANS 46
ME+ L AG L +GA + Y Y+L A G+GN G AVVTG+
Sbjct: 1 MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTD 60
Query: 47 GIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFA 106
GIGK A ELA+ G +VVL RS+++ + + +++ E E +A+D AS
Sbjct: 61 GIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIK-EKFKVETRTIAVDFASEDIYDKIK 119
Query: 107 TAFLSSEPRLDILIHNAGIS--------SCGRTREAFNLLLRVNHIGPFLLTHLLLPCLK 158
T E + IL++N G+S ++ +N + +T L+LP +
Sbjct: 120 TGLAGLE--IGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMV 177
Query: 159 ACAPSRVVVVASAA 172
+ ++ ++S +
Sbjct: 178 ERSKGAILNISSGS 191
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 54.7 bits (130), Expect = 1e-07
Identities = 54/168 (32%), Positives = 85/168 (50%), Gaps = 13/168 (7%)
Query: 10 LLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRS 69
L L +V +YY L + +LR + +TG +SG GK+ A +L RG RV+ AC +
Sbjct: 3 LYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLT 62
Query: 70 QERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFA--TAFLSSEPRLDILIHNAGISS 127
++ E LR ++ ++ + + LD+ SV A A + L L++NAGIS
Sbjct: 63 EKGAE----QLRGQT-SDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISL 117
Query: 128 CGR-----TREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVAS 170
T++ F +L VN +G +T LLP ++ A RVV V+S
Sbjct: 118 PTAPNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRR-ARGRVVNVSS 164
>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
sapiens]
Length = 315
Score = 54.3 bits (129), Expect = 2e-07
Identities = 51/171 (29%), Positives = 79/171 (46%), Gaps = 12/171 (7%)
Query: 1 MEALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRG 60
M+ LLL LGA YY P +L+G ++TGAN+G+G+ A AR G
Sbjct: 1 MKVLLLTG---LGALFFAYYWDDNFDPA----SLQGARVLLTGANAGVGEELAYHYARLG 53
Query: 61 ARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILI 120
+ +VL ++ + + R + G +V ++A D+AS + + L LD L+
Sbjct: 54 SHLVLTAHTEALLQKVVGNCR-KLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLV 112
Query: 121 HN----AGISSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVV 167
N A + R+ +A L++VN + LT LP L S VVV
Sbjct: 113 LNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVV 163
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 53.9 bits (128), Expect = 2e-07
Identities = 53/204 (25%), Positives = 92/204 (45%), Gaps = 17/204 (8%)
Query: 33 NLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFM 92
++ G+ A+VTGA GIG+ A L +GA+V L + E G L ++ + +F+
Sbjct: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFI 61
Query: 93 ALDLASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTREAFNLLLRVNHIGPFLLTHL 152
D+A +R + RLDIL++NAG+++ + + L++N + T+L
Sbjct: 62 QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNN----EKNWEKTLQINLVSVISGTYL 117
Query: 153 LLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARE-- 210
L + ++ + + G + + +PV Y +K V F R
Sbjct: 118 GLDYMSKQNGGEGGIIINMSSLAGLMPVAQ--QPV---------YCASKHGIVGFTRSAA 166
Query: 211 LANQLEATGVTCYAAHPGPVNSEL 234
LA L +GV A PG VN+ +
Sbjct: 167 LAANLMNSGVRLNAICPGFVNTAI 190
>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
sapiens]
Length = 330
Score = 53.5 bits (127), Expect = 3e-07
Identities = 52/191 (27%), Positives = 90/191 (47%), Gaps = 18/191 (9%)
Query: 1 MEAL-LLGAGLLLGAYVLV---YYNLVKA---PPCGGMGNL---RGRTAVVTGANSGIGK 50
MEAL L+GA + V +Y+L++ P G +L GR AVV+GA GIGK
Sbjct: 22 MEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGK 81
Query: 51 MTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFL 110
A ELA RG ++L R++E+ + A D+ ++ E + D +S + L
Sbjct: 82 AYAEELASRGLNIILISRNEEKLQVVAKDI-ADTYKVETDIIVADFSSGREIYLPIREAL 140
Query: 111 SSEPRLDILIHNAGI------SSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSR 164
+ + IL++N G+ + + ++ VN L+ H++LP +
Sbjct: 141 KDKD-VGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGA 199
Query: 165 VVVVASAAHCR 175
+V ++S + C+
Sbjct: 200 IVTISSGSCCK 210
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 53.5 bits (127), Expect = 3e-07
Identities = 65/228 (28%), Positives = 110/228 (48%), Gaps = 32/228 (14%)
Query: 10 LLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRS 69
L L A+V +YY L + +L+ + +TG +SG G + A +L RG RV+ AC +
Sbjct: 3 LYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLT 62
Query: 70 QERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLS---SEPRLDILIHNAG-- 124
++ E LR ++ ++ + + LD+ + S+ A AT ++ + L L++NAG
Sbjct: 63 EKGAE----QLRGQT-SDRLETVTLDVTKMESIAA-ATQWVKEHVGDRGLWGLVNNAGIL 116
Query: 125 --ISSCG--RTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDF 180
I+ C T ++ N +L+VN IG +T +LP ++ A R+V V+S GR+ F
Sbjct: 117 TPITLCEWLNTEDSMN-MLKVNLIGVIQVTLSMLPLVRR-ARGRIVNVSSIL---GRVAF 171
Query: 181 KRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPG 228
VG Y +K F+ L +++ GV PG
Sbjct: 172 ------FVG------GYCVSKYGVEAFSDILRREIQHFGVKISIVEPG 207
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 53.1 bits (126), Expect = 4e-07
Identities = 45/137 (32%), Positives = 70/137 (51%), Gaps = 13/137 (9%)
Query: 41 VTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLA 100
+TG +SG G++ AL+L +RG RV+ +C + E DL Q ++ + LD+
Sbjct: 33 ITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAE----DL-QRVASSRLHTTLLDITDPQ 87
Query: 101 SVRAFA--TAFLSSEPRLDILIHNAGISSC-----GRTREAFNLLLRVNHIGPFLLTHLL 153
SV+ A E L L++NAG++ TR+ F +L VN +GP +T L
Sbjct: 88 SVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTLAL 147
Query: 154 LPCLKACAPSRVVVVAS 170
LP L+ A RV+ + S
Sbjct: 148 LPLLQQ-ARGRVINITS 163
>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 52.4 bits (124), Expect = 7e-07
Identities = 56/222 (25%), Positives = 96/222 (43%), Gaps = 37/222 (16%)
Query: 34 LRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMA 93
+ G+ VVTGA+ GIG+ AL+L + GA V + R + A + + G + + +
Sbjct: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGG--QCVPVV 62
Query: 94 LDLASLASVRA-FATAFLSSEPRLDILIHN--AGISSCGRTR-EAF------------NL 137
D + + VR+ F + RLD+L++N AG+ + TR +AF N+
Sbjct: 63 CDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNV 122
Query: 138 LLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAY 197
LR ++ L++P +VV++S + + Y
Sbjct: 123 GLRGHYFCSVYGARLMVP----AGQGLIVVISSPGSLQYMFNV---------------PY 163
Query: 198 ADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLRHV 239
K A A + A++L GV+C + PG V +EL H+
Sbjct: 164 GVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHM 205
>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 52.4 bits (124), Expect = 7e-07
Identities = 56/222 (25%), Positives = 96/222 (43%), Gaps = 37/222 (16%)
Query: 34 LRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMA 93
+ G+ VVTGA+ GIG+ AL+L + GA V + R + A + + G + + +
Sbjct: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGG--QCVPVV 62
Query: 94 LDLASLASVRA-FATAFLSSEPRLDILIHN--AGISSCGRTR-EAF------------NL 137
D + + VR+ F + RLD+L++N AG+ + TR +AF N+
Sbjct: 63 CDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNV 122
Query: 138 LLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAY 197
LR ++ L++P +VV++S + + Y
Sbjct: 123 GLRGHYFCSVYGARLMVP----AGQGLIVVISSPGSLQYMFNV---------------PY 163
Query: 198 ADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLRHV 239
K A A + A++L GV+C + PG V +EL H+
Sbjct: 164 GVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHM 205
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 51.6 bits (122), Expect = 1e-06
Identities = 52/205 (25%), Positives = 82/205 (40%), Gaps = 26/205 (12%)
Query: 36 GRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALD 95
G+ VVTG GIG GARVV+ + + G A L QE +F+ D
Sbjct: 9 GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRA----LEQELPG--AVFILCD 62
Query: 96 LASLASVRAFATAFLSSEPRLDILIHNAGISSCGR-----TREAFNLLLRVNHIGPFLLT 150
+ V+ + + RLD +++NAG + + + F LL +N +G + LT
Sbjct: 63 VTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLT 122
Query: 151 HLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARE 210
L LP L+ + V+ ++S G + + Y TK A +
Sbjct: 123 KLALPYLRK-SQGNVINISSLVGAIG--------------QAQAVPYVATKGAVTAMTKA 167
Query: 211 LANQLEATGVTCYAAHPGPVNSELF 235
LA GV PG + + L+
Sbjct: 168 LALDESPYGVRVNCISPGNIWTPLW 192
>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
Length = 418
Score = 51.6 bits (122), Expect = 1e-06
Identities = 37/147 (25%), Positives = 68/147 (46%), Gaps = 9/147 (6%)
Query: 32 GNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQE-----RGEAAAFDLRQESGN 86
G L G T +TGA+ GIGK AL+ A+ GA +V+A ++ + G E+
Sbjct: 6 GRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVG 65
Query: 87 NEVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTREA----FNLLLRVN 142
+ + +D+ + A + +DIL++NA S T + +L++ VN
Sbjct: 66 GKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVN 125
Query: 143 HIGPFLLTHLLLPCLKACAPSRVVVVA 169
G +L + +P LK + ++ ++
Sbjct: 126 TRGTYLASKACIPYLKKSKVAHILNIS 152
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
[Homo sapiens]
Length = 178
Score = 51.2 bits (121), Expect = 1e-06
Identities = 30/95 (31%), Positives = 51/95 (53%)
Query: 33 NLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFM 92
++ G+ A+VTGA GIG+ A L +GA+V L + E G L ++ + +F+
Sbjct: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFI 61
Query: 93 ALDLASLASVRAFATAFLSSEPRLDILIHNAGISS 127
D+A +R + RLDIL++NAG+++
Sbjct: 62 QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNN 96
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 51.2 bits (121), Expect = 1e-06
Identities = 55/208 (26%), Positives = 92/208 (44%), Gaps = 28/208 (13%)
Query: 28 CGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNN 87
C +GNL + +TG +SG G + A +L RG +V+ AC ++E + Q +
Sbjct: 17 CNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKL-----QRDTSY 71
Query: 88 EVIFMALDLASLASVRAFATAFLS--SEPRLDILIHNAGIS-----SCGRTREAFNLLLR 140
+ LD+ S++A A E L L++NAG+ + T++ F ++
Sbjct: 72 RLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVIN 131
Query: 141 VNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADT 200
VN +G +T +LP +K A RVV ++S+ GR+ V+G Y +
Sbjct: 132 VNLVGLIEVTLHMLPMVKR-ARGRVVNMSSSG---GRV-------AVIG-----GGYCVS 175
Query: 201 KLANVLFARELANQLEATGVTCYAAHPG 228
K F+ + +L GV PG
Sbjct: 176 KFGVEAFSDSIRRELYYFGVKVCIIEPG 203
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 51.2 bits (121), Expect = 1e-06
Identities = 42/142 (29%), Positives = 66/142 (46%), Gaps = 7/142 (4%)
Query: 34 LRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGE---AAAFDLRQESGNNEVI 90
++ + V+T A SG+GK A GAR+VL ++ ER E A + S
Sbjct: 35 VQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPK 94
Query: 91 FMALDLASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTR----EAFNLLLRVNHIGP 146
+ LDL+ ++ V A L +DILI+NA + G E ++ N+ GP
Sbjct: 95 LVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGP 154
Query: 147 FLLTHLLLPCLKACAPSRVVVV 168
LT LLP + + ++V+V
Sbjct: 155 ITLTKALLPNMISRRTGQIVLV 176
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,788,498
Number of Sequences: 37866
Number of extensions: 813128
Number of successful extensions: 5982
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 107
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 5471
Number of HSP's gapped (non-prelim): 604
length of query: 377
length of database: 18,247,518
effective HSP length: 104
effective length of query: 273
effective length of database: 14,309,454
effective search space: 3906480942
effective search space used: 3906480942
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.