BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|14550407 complement component 2 isoform 1 preproprotein [Homo sapiens] (752 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|14550407 complement component 2 isoform 1 preproprotein [Homo... 1553 0.0 gi|225543438 complement component 2 isoform 2 preproprotein [Hom... 1238 0.0 gi|67782358 complement factor B preproprotein [Homo sapiens] 515 e-146 gi|148886654 polydom [Homo sapiens] 102 2e-21 gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 101 3e-21 gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 96 9e-20 gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 96 9e-20 gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 96 9e-20 gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa... 83 8e-16 gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap... 83 8e-16 gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 82 2e-15 gi|205360905 testis-specific serine protease 1 [Homo sapiens] 82 2e-15 gi|148231605 ovochymase 2 [Homo sapiens] 82 2e-15 gi|187960042 selectin E precursor [Homo sapiens] 80 7e-15 gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 78 3e-14 gi|157419154 selectin P precursor [Homo sapiens] 77 8e-14 gi|13994276 marapsin [Homo sapiens] 76 1e-13 gi|4506115 protein C [Homo sapiens] 75 3e-13 gi|32698940 transmembrane protease, serine 12 [Homo sapiens] 75 3e-13 gi|4502495 complement component 1, s subcomponent precursor [Hom... 74 4e-13 gi|41393602 complement component 1, s subcomponent precursor [Ho... 74 4e-13 gi|4506153 prostasin preproprotein [Homo sapiens] 74 5e-13 gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens] 74 6e-13 gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo ... 74 6e-13 gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo ... 74 6e-13 gi|148806900 epidermis-specific serine protease-like protein [Ho... 74 6e-13 gi|62912468 complement component 4 binding protein, beta chain i... 73 8e-13 gi|62912464 complement component 4 binding protein, beta chain i... 73 8e-13 gi|4502505 complement component 4 binding protein, beta chain is... 73 8e-13 gi|187761337 transmembrane protease, serine 11B [Homo sapiens] 73 8e-13 >gi|14550407 complement component 2 isoform 1 preproprotein [Homo sapiens] Length = 752 Score = 1553 bits (4022), Expect = 0.0 Identities = 752/752 (100%), Positives = 752/752 (100%) Query: 1 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA 60 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA Sbjct: 1 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA 60 Query: 61 SRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG 120 SRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG Sbjct: 61 SRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG 120 Query: 121 FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSN 180 FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSN Sbjct: 121 FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSN 180 Query: 181 LVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKES 240 LVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKES Sbjct: 181 LVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKES 240 Query: 241 LGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFAS 300 LGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFAS Sbjct: 241 LGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFAS 300 Query: 301 EPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGME 360 EPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGME Sbjct: 301 EPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGME 360 Query: 361 TMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDW 420 TMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDW Sbjct: 361 TMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDW 420 Query: 421 RELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPW 480 RELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPW Sbjct: 421 RELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPW 480 Query: 481 HVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVI 540 HVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVI Sbjct: 481 HVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVI 540 Query: 541 SPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTC 600 SPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTC Sbjct: 541 SPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTC 600 Query: 601 RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVT 660 RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVT Sbjct: 601 RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVT 660 Query: 661 DQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRS 720 DQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRS Sbjct: 661 DQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRS 720 Query: 721 KVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL 752 KVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL Sbjct: 721 KVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL 752 >gi|225543438 complement component 2 isoform 2 preproprotein [Homo sapiens] Length = 620 Score = 1238 bits (3204), Expect = 0.0 Identities = 605/605 (100%), Positives = 605/605 (100%) Query: 148 AGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP 207 AGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP Sbjct: 16 AGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP 75 Query: 208 YSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSE 267 YSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSE Sbjct: 76 YSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSE 135 Query: 268 NDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENAN 327 NDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENAN Sbjct: 136 NDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENAN 195 Query: 328 YKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKT 387 YKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKT Sbjct: 196 YKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKT 255 Query: 388 AVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQ 447 AVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQ Sbjct: 256 AVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQ 315 Query: 448 VFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAH 507 VFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAH Sbjct: 316 VFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAH 375 Query: 508 CFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKL 567 CFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKL Sbjct: 376 CFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKL 435 Query: 568 AQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNI 627 AQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNI Sbjct: 436 AQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNI 495 Query: 628 NLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLER 687 NLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLER Sbjct: 496 NLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLER 555 Query: 688 RFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVL 747 RFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVL Sbjct: 556 RFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVL 615 Query: 748 NFLPL 752 NFLPL Sbjct: 616 NFLPL 620 Score = 49.3 bits (116), Expect = 1e-05 Identities = 31/71 (43%), Positives = 37/71 (52%), Gaps = 7/71 (9%) Query: 1 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA 60 MGPLMVLFCLLFLYP A CP N IS G + G + Y C L + + Sbjct: 1 MGPLMVLFCLLFLYP-----AGHCP-NPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS 54 Query: 61 S-RLCKSSGQW 70 S R C+ +G W Sbjct: 55 SERECQGNGVW 65 Score = 38.1 bits (87), Expect = 0.030 Identities = 13/35 (37%), Positives = 19/35 (54%) Query: 110 GGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVC 144 G V + C +L GS R+C+ NG+W G +C Sbjct: 38 GDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 72 >gi|67782358 complement factor B preproprotein [Homo sapiens] Length = 764 Score = 515 bits (1326), Expect = e-146 Identities = 297/751 (39%), Positives = 424/751 (56%), Gaps = 44/751 (5%) Query: 17 LADSAPSCP-QNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA-SRLCKSSGQWQTPG 74 LA SC + V I GG+F L G L Y CP G YP P +R C+S+G W T Sbjct: 30 LARPQGSCSLEGVEIKGGSFRLLQ---EGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLK 86 Query: 75 AT--RSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCR 132 +++ KA C+ + CP P FENG Y PR Y V +SF C DG+ LRGS R C+ Sbjct: 87 TQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQ 146 Query: 133 PNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQ 192 NG W G+TA+CDNGAG+C NPGI +G + G ++ D V Y CS L L GS R CQ Sbjct: 147 VNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQ 206 Query: 193 GNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPT--QKTKESLGRKIQIQRS 250 G WSGTEP C+ + YD P++VA A +S + + + E RKI + S Sbjct: 207 EGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPS 266 Query: 251 GHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLN 310 G +N+YL+LD S S+ ++F K+ +++++ S+ + ++T+A+ PK+ + V Sbjct: 267 GSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSE 326 Query: 311 DNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHA 370 +S + V L NY+DH+ +GTNT AL +VY MM+ + W RH Sbjct: 327 ADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPD---DVPPEGWNRTRHV 383 Query: 371 IILLTDGKSNMGGSPKTAVDHIREILNINQ----KRNDYLDIYAIGVGKLDVDWRELNEL 426 IIL+TDG NMGG P T +D IR++L I + R DYLD+Y GVG L V+ +N L Sbjct: 384 IILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPL-VNQVNINAL 442 Query: 427 GSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIK- 485 SKKD E+H F ++D + L VF M+D S+ + ++CG+ +D + PW I Sbjct: 443 ASKKDNEQHVFKVKDMENLEDVFYQMIDESQ-SLSLCGMVWEHRKGTDYHKQPWQAKISV 501 Query: 486 ---PKSQETCRGALISDQWVLTAAHCFR-DGNDHSLWRVNVGDPKSQWGKEFLIEKAVIS 541 K E+C GA++S+ +VLTAAHCF D +HS+ +V+VG K ++ IE + Sbjct: 502 IRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSI-KVSVGGEK----RDLEIEVVLFH 556 Query: 542 PGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCR 601 P +++ KK GI EFY D+AL+KL K+K RPICLPCT ALR P +TC+ Sbjct: 557 PNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQ 616 Query: 602 DHENELLNKQSVPAHFVALNGSKL---NINLKMGVEWTSCAEVVSQEKTMFPNLTDVREV 658 + ELL Q + A FV+ KL + +K G + SC E +Q + + D+ EV Sbjct: 617 QQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSC-ERDAQYAPGYDKVKDISEV 675 Query: 659 VTDQFLCSG---TQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRK 715 VT +FLC+G D + C+G+SGG + + +R RF QVG++SWG+ + C KN ++ Sbjct: 676 VTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVC-----KNQKR 730 Query: 716 RAPRSKVPP-PRDFHINLFRMQPWLRQHLGD 745 + +VP RDFHINLF++ PWL++ L D Sbjct: 731 ---QKQVPAHARDFHINLFQVLPWLKEKLQD 758 >gi|148886654 polydom [Homo sapiens] Length = 3571 Score = 102 bits (253), Expect = 2e-21 Identities = 63/186 (33%), Positives = 86/186 (46%), Gaps = 18/186 (9%) Query: 20 SAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRS 78 S+P N + G +T + Y+C +G L SR+C ++G W GAT Sbjct: 2834 SSPPVSANGQVRGDEYTFQKE------IEYTCNEGFLLEGARSRVCLANGSWS--GATPD 2885 Query: 79 LSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWD 138 C PVRC P NG+ T L Y V+F C +G+IL G+P C+ +G WD Sbjct: 2886 -----CVPVRCATPPQLANGV-TEGL-DYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWD 2938 Query: 139 GETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWS 198 E +C +C P GF F HG ++Y+C L G+S R C NG WS Sbjct: 2939 AEIPLCK--PVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWS 2996 Query: 199 GTEPIC 204 G+ P C Sbjct: 2997 GSSPSC 3002 Score = 85.9 bits (211), Expect = 1e-16 Identities = 52/164 (31%), Positives = 77/164 (46%), Gaps = 14/164 (8%) Query: 44 GSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAP-VSFENGIYT 101 G + YSC +G P+ C +G W P +CKP CP P V EN + + Sbjct: 3318 GPNVVYSCNRGYSLEGPSEAHCTENGTWSHP-------VPLCKPNPCPVPFVIPENALLS 3370 Query: 102 PRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAV 161 + + V NVS +C +GF+L+G + C P+ W +A C+ + C P A+ Sbjct: 3371 EK--EFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKIS--CGPPAHVENAI 3426 Query: 162 RTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205 G + +GD + Y C S +L G C NG W+ + PICR Sbjct: 3427 ARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWT-SPPICR 3469 Score = 85.1 bits (209), Expect = 2e-16 Identities = 58/209 (27%), Positives = 83/209 (39%), Gaps = 19/209 (9%) Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLS 80 P+ N +I G +T S L Y C G + R C+ W Sbjct: 2778 PNPVMNGSIKGSNYTYL------STLYYECDPGYVLNGTERRTCQDDKNWDE-------D 2824 Query: 81 KAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGE 140 + +C PV C +P NG R Y + + C +GF+L G+ R C NG W G Sbjct: 2825 EPICIPVDCSSPPVSANG--QVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGA 2882 Query: 141 TAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGT 200 T C C P V G +G +V + C +L G+ + CQ +G W Sbjct: 2883 TPDCV--PVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAE 2940 Query: 201 EPICRQPYSYDFPEDVAPALGTSFSHMLG 229 P+C+ P + PED+A FS + G Sbjct: 2941 IPLCK-PVNCGPPEDLAHGFPNGFSFIHG 2968 Score = 82.0 bits (201), Expect = 2e-15 Identities = 59/202 (29%), Positives = 82/202 (40%), Gaps = 18/202 (8%) Query: 20 SAPSCPQNVNISGGTFTLSHG--WAPGSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGAT 76 S CP NI T L HG ++ ++ SC +G + +C+ G W+ P + Sbjct: 3177 SPKKCPLPENI---THILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSD 3233 Query: 77 RSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGM 136 S C PV C P S E+G Y + ++CE G+ L G+ R C+ N Sbjct: 3234 ES-----CSPVSCGKPESPEHGFVVG--SKYTFESTIIYQCEPGYELEGNRERVCQENRQ 3286 Query: 137 WDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV 196 W G A+C C P L G V Y C+ L G SE C NG Sbjct: 3287 WSGGVAICKE--TRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGT 3344 Query: 197 WSGTEPICRQ---PYSYDFPED 215 WS P+C+ P + PE+ Sbjct: 3345 WSHPVPLCKPNPCPVPFVIPEN 3366 Score = 81.3 bits (199), Expect = 3e-15 Identities = 54/184 (29%), Positives = 76/184 (41%), Gaps = 18/184 (9%) Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGATRSLS 80 P+ P+N I FT GS +TY C +G C ++ W S S Sbjct: 1850 PAIPENGCIEELAFTF------GSKVTYRCNKGYTLAGDKESSCLANSSW-------SHS 1896 Query: 81 KAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGE 140 VC+PV+C +P + NG Y L S+ C+ G+ L+G + +C +G+WD Sbjct: 1897 PPVCEPVKCSSPENINNGKYI--LSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRA 1954 Query: 141 TAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGT 200 C C P AV TG F + V Y C L G EC +G WS + Sbjct: 1955 PPACH--LVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRS 2012 Query: 201 EPIC 204 + C Sbjct: 2013 DQQC 2016 Score = 80.9 bits (198), Expect = 4e-15 Identities = 58/210 (27%), Positives = 80/210 (38%), Gaps = 44/210 (20%) Query: 44 GSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSL----------------------- 79 GS +TY C G Y SR+ C +G W G + S Sbjct: 1709 GSTVTYQCNNGYYLLGDSRMFCTDNGSWN--GVSPSCLDVDECAVGSDCSEHASCLNVDG 1766 Query: 80 -------------SKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGS 126 K +P++C AP + ENG + + Y VG V+F C++G+ L G Sbjct: 1767 SYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI--YTVGAEVTFSCQEGYQLMGV 1824 Query: 127 PVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS 186 C +G W+ C A C P I F G KV YRC+ L G Sbjct: 1825 TKITCLESGEWNHLIPYCK--AVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGD 1882 Query: 187 SERECQGNGVWSGTEPICRQPYSYDFPEDV 216 E C N WS + P+C +P PE++ Sbjct: 1883 KESSCLANSSWSHSPPVC-EPVKCSSPENI 1911 Score = 80.1 bits (196), Expect = 7e-15 Identities = 54/183 (29%), Positives = 77/183 (42%), Gaps = 11/183 (6%) Query: 35 FTLSHGWAPGSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPV 93 F + GS + + C +G +S C+ SG+W S C P +CP P Sbjct: 2274 FMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKK------SNPKCMPAKCPEPP 2327 Query: 94 SFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPN 153 EN + L + G V+F C++G +L+G V +C P+ W+ VC P Sbjct: 2328 LLENQLVLKELTTEV--GVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLC-TPP 2384 Query: 154 PGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFP 213 P IS G G V+Y C L G+S CQ +G WS P C P P Sbjct: 2385 PLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPEC-VPVECPQP 2443 Query: 214 EDV 216 E++ Sbjct: 2444 EEI 2446 Score = 79.7 bits (195), Expect = 9e-15 Identities = 51/171 (29%), Positives = 78/171 (45%), Gaps = 14/171 (8%) Query: 36 TLSHGWAPGSLLTYSCPQG--LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPV 93 T S + G++++Y+C G L +P +C+ G W S C + C P Sbjct: 2670 THSSNFLYGTMVSYTCNPGYELLGNPVL-ICQEDGTWNG-------SAPSCISIECDLPT 2721 Query: 94 SFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPN 153 + ENG R +G V + C+ G IL GS +R C N W G + C+ + PN Sbjct: 2722 APENGFL--RFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPN 2779 Query: 154 PGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 P + G+++ G + + + Y C VL G+ R CQ + W EPIC Sbjct: 2780 P-VMNGSIK-GSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPIC 2828 Score = 76.3 bits (186), Expect = 1e-13 Identities = 51/176 (28%), Positives = 78/176 (44%), Gaps = 11/176 (6%) Query: 24 CPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASR-LCKSSGQWQTPGATRSLSKA 82 C + +I G + ++ G+++ YSC +G Y + C+++GQW +P T Sbjct: 2146 CGEPPSIMNG-YASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPT------ 2198 Query: 83 VCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETA 142 C PV C P ENG G V ++C G+ GSPV C+ N W E+ Sbjct: 2199 -CHPVSCGEPPKVENGFLEHTTGRI-FESEVRYQCNPGYKSVGSPVFVCQANRHWHSESP 2256 Query: 143 VCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWS 198 + P I G ++ G F G KV++ C+ L G S CQ +G W+ Sbjct: 2257 LMCVPLDCGKPPPIQNGFMK-GENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWN 2311 Score = 76.3 bits (186), Expect = 1e-13 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 12/162 (7%) Query: 44 GSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102 GS + YSC G + RLC + +W GA+ C+ + C P NG + Sbjct: 2736 GSAVQYSCKPGHILAGSDLRLCLENRKWS--GASPR-----CEAISCKKPNPVMNG--SI 2786 Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162 + +Y + +EC+ G++L G+ R C+ + WD + +C C +P +S Sbjct: 2787 KGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICI--PVDCSSPPVSANGQV 2844 Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 G + ++ Y C+ +L G+ R C NG WSG P C Sbjct: 2845 RGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDC 2886 Score = 70.5 bits (171), Expect = 6e-12 Identities = 48/178 (26%), Positives = 70/178 (39%), Gaps = 11/178 (6%) Query: 41 WAPGSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGI 99 +A GS++++ C +G + ++++ C GQW S C PVRC P S NG Sbjct: 2102 FAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNP-----SPMSIQCIPVRCGEPPSIMNGY 2156 Query: 100 YTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDN-GAGHCPNPGISL 158 + +Y G V++ C GF ++G C G W C G P Sbjct: 2157 ASG--SNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGF 2214 Query: 159 GAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDV 216 TG F +VRY+C+ GS CQ N W P+ P P + Sbjct: 2215 LEHTTGRIFE--SEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPI 2270 Score = 69.3 bits (168), Expect = 1e-11 Identities = 45/161 (27%), Positives = 63/161 (39%), Gaps = 11/161 (6%) Query: 46 LLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRL 104 ++T+SC +G + P+ C S QW S VCK V C P G+ P Sbjct: 2344 VVTFSCKEGHVLQGPSVLKCLPSQQWND-------SFPVCKIVLCTPPPLISFGVPIPSS 2396 Query: 105 GSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTG 164 + G V + C GF LRG+ C+P+G W C CP P + Sbjct: 2397 ALH-FGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECV--PVECPQPEEIPNGIIDV 2453 Query: 165 FRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205 + Y C L G++ C NG W G +P C+ Sbjct: 2454 QGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCK 2494 Score = 67.8 bits (164), Expect = 4e-11 Identities = 55/184 (29%), Positives = 75/184 (40%), Gaps = 14/184 (7%) Query: 44 GSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102 G + Y C G +SR C S+G W S S C P RC PV E G T Sbjct: 2968 GGHIQYQCFPGYKLHGNSSRRCLSNGSW-------SGSSPSCLPCRCSTPV-IEYG--TV 3017 Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162 + G +C GF L G C +G W C++ + C + + A Sbjct: 3018 NGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTS--CGSLPMIPNAFI 3075 Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGT 222 + + + Y C S V+ GSS+ C GVWS P+C +P S P VA A+ T Sbjct: 3076 SETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVC-EPLSCGSPPSVANAVAT 3134 Query: 223 SFSH 226 +H Sbjct: 3135 GEAH 3138 Score = 67.4 bits (163), Expect = 5e-11 Identities = 50/182 (27%), Positives = 71/182 (39%), Gaps = 14/182 (7%) Query: 24 CPQNVNISGGTFTLSHGWAPGSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGATRSLSKA 82 CPQ I G + G A S Y+C G + LC +G W K Sbjct: 2440 CPQPEEIPNGIIDVQ-GLAYLSTALYTCKPGFELVGNTTTLCGENGHWLG-------GKP 2491 Query: 83 VCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETA 142 CK + C P NG ++ Y G V++ C GF L G C G WD + Sbjct: 2492 TCKAIECLKPKEILNGKFSYTDLHY--GQTVTYSCNRGFRLEGPSALTCLETGDWDVDAP 2549 Query: 143 VCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEP 202 C+ A HC +P G + +G + Y C + G + + C+ +G WS + P Sbjct: 2550 SCN--AIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIP 2606 Query: 203 IC 204 C Sbjct: 2607 TC 2608 Score = 67.0 bits (162), Expect = 6e-11 Identities = 43/174 (24%), Positives = 68/174 (39%), Gaps = 4/174 (2%) Query: 44 GSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102 G + Y C G + S+L C + G+W P + + + + P VS+ + + Sbjct: 2040 GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEG-QDMPRCIAHFCEKPPSVSYSI-LESV 2097 Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162 + G VSF+C +GF+L S +C G W+ C P + Sbjct: 2098 SKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYA 2157 Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDV 216 +G + G V Y C+ + G + C+ G WS P C P S P V Sbjct: 2158 SGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTC-HPVSCGEPPKV 2210 Score = 66.6 bits (161), Expect = 8e-11 Identities = 53/192 (27%), Positives = 70/192 (36%), Gaps = 31/192 (16%) Query: 50 SCPQGLYPSPASR-------LCKSSGQWQTPGATRS----------LSKAVCKPVRCPAP 92 +CP G Y S C PG+T S C+ V CPA Sbjct: 322 ACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPAL 381 Query: 93 VSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCP 152 ENG + + C GF L GS + C PNG+W G + C CP Sbjct: 382 KPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYC--RVRTCP 439 Query: 153 NPGISLGAVRTGFRFGHGDKVRYR------CSSNLVLTGSSERECQGNGVWSGTEPIC-- 204 + L + G ++ Y+ C L GS + CQGN W G EP C Sbjct: 440 H----LRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVE 495 Query: 205 RQPYSYDFPEDV 216 R ++ P+DV Sbjct: 496 RHCSTFQMPKDV 507 Score = 57.8 bits (138), Expect = 4e-08 Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 10/99 (10%) Query: 110 GGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFR--- 166 G V+ C+ GF L G+PV+ C G W C+ + P P + GF Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPP------LENGFHSAD 1704 Query: 167 -FGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 F G V Y+C++ L G S C NG W+G P C Sbjct: 1705 DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSC 1743 Score = 57.4 bits (137), Expect = 5e-08 Identities = 50/211 (23%), Positives = 74/211 (35%), Gaps = 51/211 (24%) Query: 36 TLSHGWAPGSLLTYSCPQG--LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPV 93 T S PGS + C G L +P + C + GQW P C+ + C P Sbjct: 1643 TASEDLKPGSKVNLFCDPGFQLVGNPV-QYCLNQGQWTQP-------LPHCERISCGVPP 1694 Query: 94 SFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDG-------------- 139 ENG ++ + G V+++C +G+ L G C NG W+G Sbjct: 1695 PLENGFHS--ADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVG 1752 Query: 140 ----ETAVCDNGAG---------------------HCPNPGISLGAVRTGFRFGHGDKVR 174 E A C N G C PG +G + G +V Sbjct: 1753 SDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVT 1812 Query: 175 YRCSSNLVLTGSSERECQGNGVWSGTEPICR 205 + C L G ++ C +G W+ P C+ Sbjct: 1813 FSCQEGYQLMGVTKITCLESGEWNHLIPYCK 1843 >gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] Length = 3565 Score = 101 bits (251), Expect = 3e-21 Identities = 70/224 (31%), Positives = 100/224 (44%), Gaps = 25/224 (11%) Query: 20 SAPSCPQNVNISGGTFTLSHGWAPGSLLT------YSCPQGLYP---SPASRLCKSSGQW 70 +AP C + G TL++G G+ T Y C G + A+ C G+W Sbjct: 3029 TAPDC--TIISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRW 3086 Query: 71 QTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQ 130 SK VCK V CP P +NG T + G ++S+ C DG+ L S + Sbjct: 3087 NP-------SKPVCKAVLCPQPPPVQNG--TVEGSDFRWGSSISYSCMDGYQLSHSAILS 3137 Query: 131 CRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERE 190 C G+W GE C C +PGI +G F + +V ++C S +L GSS R Sbjct: 3138 CEGRGVWKGEIPQCL--PVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRV 3195 Query: 191 CQGNGVWSGTEPICRQPYSYDFPEDVAPALG---TSFSHMLGAT 231 CQ +G WSG +P C P P+ P G +S + +G+T Sbjct: 3196 CQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGST 3239 Score = 92.8 bits (229), Expect = 1e-18 Identities = 59/177 (33%), Positives = 82/177 (46%), Gaps = 19/177 (10%) Query: 38 SHGWAPGS------LLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCP 90 +HG+ GS ++ ++C G SR C+S+GQW +P T C+ V C Sbjct: 2746 AHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPT-------CRVVNCS 2798 Query: 91 APVSFENGIYTPRLG---SYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNG 147 P EN I + S+ G ++ + C+ GF L GS C NG+WD C Sbjct: 2799 DPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKC--L 2856 Query: 148 AGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 A C +PG+ AV TG F +G V Y C + L G+ R CQ + WSG P C Sbjct: 2857 AISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHC 2913 Score = 82.0 bits (201), Expect = 2e-15 Identities = 54/163 (33%), Positives = 71/163 (43%), Gaps = 11/163 (6%) Query: 44 GSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102 G + Y C +G Y +S L C ++G W RSL K C + C P N + T Sbjct: 2821 GMSILYHCKKGFYLLGSSALTCMANGLWD-----RSLPK--CLAISCGHPGVPANAVLTG 2873 Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCD-NGAGHCPNPGISLGAV 161 L +Y G V + C L G+ R C+ + W G C N G C +PG Sbjct: 2874 ELFTY--GAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGS 2931 Query: 162 RTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 R G F +R+ C L GS ER C NG WSG +P+C Sbjct: 2932 RLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVC 2974 Score = 79.7 bits (195), Expect = 9e-15 Identities = 52/162 (32%), Positives = 72/162 (44%), Gaps = 10/162 (6%) Query: 44 GSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102 G+ + SC G Y L C+++G W S C+ + C + NG Sbjct: 2582 GAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPS-----CRVISCGSLSFPPNGNKIG 2636 Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162 L Y G F C G+ L GS VR+C NG+W G C AGHC +P + Sbjct: 2637 TLTVY--GATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCL--AGHCGSPDPIVNGHI 2692 Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 +G F + D V Y+C+ L G+S R C + WSG P+C Sbjct: 2693 SGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVC 2734 Score = 73.2 bits (178), Expect = 8e-13 Identities = 61/201 (30%), Positives = 83/201 (41%), Gaps = 30/201 (14%) Query: 17 LADSAPSC----------PQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPAS--RLC 64 + D PSC P N N GT T+ G+ ++C G Y S R C Sbjct: 2611 IGDERPSCRVISCGSLSFPPNGN-KIGTLTVY-----GATAIFTCNTG-YTLVGSHVREC 2663 Query: 65 KSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILR 124 ++G W S S+ C C +P NG + SY V ++C GF L Sbjct: 2664 LANGLW-------SGSETRCLAGHCGSPDPIVNGHISGDGFSYR--DTVVYQCNPGFRLV 2714 Query: 125 GSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT 184 G+ VR C + W G+T VC C +PG G F D V + C++ +L Sbjct: 2715 GTSVRICLQDHKWSGQTPVCVPIT--CGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQ 2772 Query: 185 GSSERECQGNGVWSGTEPICR 205 G S +C+ NG WS P CR Sbjct: 2773 GVSRAQCRSNGQWSSPLPTCR 2793 Score = 72.8 bits (177), Expect = 1e-12 Identities = 59/189 (31%), Positives = 80/189 (42%), Gaps = 24/189 (12%) Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSC--PQGLYPSPASRLCKSSGQWQ--TPGATR 77 P P N ++G FT G+++ YSC + L + +R+C+ W P T Sbjct: 2863 PGVPANAVLTGELFTY------GAVVHYSCRGSESLIGND-TRVCQEDSHWSGALPHCTG 2915 Query: 78 SLSKAVCKPVRCPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRPNGM 136 + P C P + +G RLG + + F CE G LRGSP R C NG Sbjct: 2916 N------NPGFCGDPGTPAHG---SRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGS 2966 Query: 137 WDGETAVCDNGAGHCPNPGI-SLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNG 195 W G VC+ A C NPG + G + + V Y C +G R C NG Sbjct: 2967 WSGLQPVCE--AVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANG 3024 Query: 196 VWSGTEPIC 204 W+GT P C Sbjct: 3025 TWTGTAPDC 3033 Score = 62.8 bits (151), Expect = 1e-09 Identities = 53/189 (28%), Positives = 73/189 (38%), Gaps = 20/189 (10%) Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLS 80 P P +SG +FT S + + C + + R+C++ G W + Sbjct: 3159 PGIPAEGRLSGKSFTYK------SEVFFQCKSPFILVGSSRRVCQADGTWS------GIQ 3206 Query: 81 KAVCKPVR--CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWD 138 P CP P + GI G Y VG V F C G+ ++GS R C N W Sbjct: 3207 PTCIDPAHNTCPDPGTPHFGIQNSSRG-YEVGSTVFFRCRKGYHIQGSTTRTCLANLTWS 3265 Query: 139 GETAVCDNGAGHCPNPGISLGA-VRTGFRFGHGDKVRYRCSSNLVLTGSSE-RECQGNGV 196 G C A C P A VR G + Y C L G SE R C+ + Sbjct: 3266 GIQTECIPHA--CRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMK 3323 Query: 197 WSGTEPICR 205 W+G P+C+ Sbjct: 3324 WTGKSPVCK 3332 Score = 54.3 bits (129), Expect = 4e-07 Identities = 55/200 (27%), Positives = 80/200 (40%), Gaps = 23/200 (11%) Query: 20 SAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGL-YPSPASRLCKSS--GQWQTPGAT 76 +AP C + G A GS + Y C G ++ C+ + G +Q T Sbjct: 2429 AAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLT 2488 Query: 77 RSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSP--VRQCRPN 134 +C+ V C P S NG +T + + V +EC +GF L S C+ + Sbjct: 2489 -----PLCQAVSCGIPESPGNGSFTGN--EFTLDSKVVYECHEGFKLESSQQATAVCQED 2541 Query: 135 GMWD--GETAVCDNGAGHCPNPGISLGA-----VRTGFRFGHGDKVRYRCSSNLVLTGSS 187 G+W G+ C A CP+ L + +G +G +V CS L G Sbjct: 2542 GLWSNKGKPPTCKPVA--CPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWR 2599 Query: 188 ERECQGNGVWS-GTE-PICR 205 CQ NG W+ G E P CR Sbjct: 2600 LLRCQANGTWNIGDERPSCR 2619 Score = 50.4 bits (119), Expect = 6e-06 Identities = 23/56 (41%), Positives = 28/56 (50%) Query: 149 GHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 G C +PGI RTG F HGD + + C + L G CQ N WSG +P C Sbjct: 526 GGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581 Score = 45.1 bits (105), Expect = 2e-04 Identities = 26/65 (40%), Positives = 29/65 (44%), Gaps = 4/65 (6%) Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT-GSSEREC---QGNGVWSGTEP 202 G C +PGI + R G RF G V + C V T GS C GN VWS T P Sbjct: 694 GQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVP 753 Query: 203 ICRQP 207 C P Sbjct: 754 RCEAP 758 Score = 45.1 bits (105), Expect = 2e-04 Identities = 26/64 (40%), Positives = 32/64 (50%), Gaps = 4/64 (6%) Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRP--NGMWDGETAVCDN 146 CP P F+NG Y VG +VSFEC G+IL G PV C+ N W+ CD Sbjct: 2088 CPDPPPFQNGYMIN--SDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDA 2145 Query: 147 GAGH 150 G+ Sbjct: 2146 PCGY 2149 Score = 44.7 bits (104), Expect = 3e-04 Identities = 25/59 (42%), Positives = 28/59 (47%), Gaps = 4/59 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC---QGNGV-WSGTEPICR 205 C NPG L V G RF GDK+RY C +L G + C GNG W P CR Sbjct: 145 CGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCR 203 Score = 43.5 bits (101), Expect = 7e-04 Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 2/56 (3%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNG--VWSGTEPIC 204 C +PG+ + R GF FG GD + + C L G+++ C G G VWS P C Sbjct: 1046 CDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRC 1101 Score = 42.4 bits (98), Expect = 0.002 Identities = 32/106 (30%), Positives = 43/106 (40%), Gaps = 11/106 (10%) Query: 110 GGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNG-----AGHCPNPGISLGAVRTG 164 G N F+ + L+ V+ P+ + +V G + CP+PGI R G Sbjct: 304 GFNAQFQVKKAIELKSRGVKML-PSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAG 362 Query: 165 FRFGH-GDKVRYRCSSNLVLTGSSERECQ----GNGVWSGTEPICR 205 F G V++ C N VL GS CQ WS PICR Sbjct: 363 SDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR 408 Score = 36.6 bits (83), Expect = 0.088 Identities = 29/92 (31%), Positives = 39/92 (42%), Gaps = 5/92 (5%) Query: 162 RTGFRFGHGDKVRYRCSSNLVLTGSSERECQG--NGV--WSGTEPICRQPYSYDFPEDVA 217 R G F G VR+ C+ +L GS+ CQ N + W+ T P C P S +F + Sbjct: 1753 RIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPCSGNFTQRRG 1812 Query: 218 PALGTSFSHMLGAT-NPTQKTKESLGRKIQIQ 248 L + G N K + G IQIQ Sbjct: 1813 TILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQ 1844 Score = 35.4 bits (80), Expect = 0.20 Identities = 21/46 (45%), Positives = 25/46 (54%), Gaps = 5/46 (10%) Query: 89 CPAPVSFENGIYTPRLGS--YPVGGNVSFECEDGFILRGSPVRQCR 132 CP P ENG R GS VG NV F CED ++L+GS C+ Sbjct: 349 CPDPGIPENG---RRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQ 391 Score = 33.5 bits (75), Expect = 0.75 Identities = 19/80 (23%), Positives = 27/80 (33%), Gaps = 4/80 (5%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICRQ 206 C +PG + R G F G + Y+C S + S C G W P C Sbjct: 1565 CFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNA 1624 Query: 207 PYSYDFPEDVAPALGTSFSH 226 P + L ++ H Sbjct: 1625 PCGGQYTGSEGVVLSPNYPH 1644 Score = 33.1 bits (74), Expect = 0.97 Identities = 16/54 (29%), Positives = 22/54 (40%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 C +PGI + R G FG V + C L+ C+ N W+ P C Sbjct: 874 CLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC 927 Score = 32.3 bits (72), Expect = 1.7 Identities = 17/46 (36%), Positives = 21/46 (45%), Gaps = 1/46 (2%) Query: 100 YTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVC 144 Y R GS + G ++FEC F L G V C+ N W G C Sbjct: 536 YGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC 581 Score = 32.3 bits (72), Expect = 1.7 Identities = 18/50 (36%), Positives = 26/50 (52%), Gaps = 5/50 (10%) Query: 100 YTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCR--PNGM--WDGETAVC 144 Y R+GS + G V FEC G++L+GS C+ PN + W+ C Sbjct: 1750 YGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799 >gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens] Length = 3667 Score = 96.3 bits (238), Expect = 9e-20 Identities = 57/172 (33%), Positives = 82/172 (47%), Gaps = 12/172 (6%) Query: 36 TLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVS 94 T +G+ ++T+SC G L P C+++ QW P +CK V C P Sbjct: 2846 TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHP-------PPMCKVVNCSDPGI 2898 Query: 95 FENGIYTPRL--GSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCP 152 N ++ G++ G V ++C G+ L GS V C+PNG WD C C Sbjct: 2899 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI--MIDCG 2956 Query: 153 NPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 +PG+ AV +G ++ G V Y C+ L G S R CQ NG WSG++P C Sbjct: 2957 HPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 3008 Score = 82.8 bits (203), Expect = 1e-15 Identities = 59/192 (30%), Positives = 77/192 (40%), Gaps = 21/192 (10%) Query: 20 SAPSCPQNVN----ISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRL-CKSSGQWQTPG 74 S P P N I G FT G+++ Y C G + +S L C+ +GQW P Sbjct: 2894 SDPGIPANSKRESKIEHGNFTY------GTVVFYDCNPGYFLFGSSVLICQPNGQWDKP- 2946 Query: 75 ATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPN 134 C + C P N + + Y G V + C L G R C+ N Sbjct: 2947 ------LPECIMIDCGHPGVPPNAVLSGE--KYTFGSTVHYSCTGKRSLLGQSSRTCQLN 2998 Query: 135 GMWDGETAVCDNGA-GHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG 193 G W G C A G C +PG R F VRY C + +L GS ER C Sbjct: 2999 GHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 3058 Query: 194 NGVWSGTEPICR 205 NG W+G +P C+ Sbjct: 3059 NGSWTGRQPECK 3070 Score = 82.4 bits (202), Expect = 1e-15 Identities = 52/167 (31%), Positives = 71/167 (42%), Gaps = 14/167 (8%) Query: 44 GSLLTYSCPQGL---YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIY 100 G ++Y C G R C +G W T C+ V CP P NG Sbjct: 3152 GQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPT-------CRAVTCPTPPQISNGRL 3204 Query: 101 TPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA 160 ++ G ++S+ C G+ L V C NG W GE C C +PGI Sbjct: 3205 EGT--NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL--PKFCGDPGIPAQG 3260 Query: 161 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP 207 R G F + +V + C+ +L GSS R CQ +G WSG+ P C +P Sbjct: 3261 KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEP 3307 Score = 80.5 bits (197), Expect = 5e-15 Identities = 59/196 (30%), Positives = 83/196 (42%), Gaps = 19/196 (9%) Query: 19 DSAPSCPQNVNISGGTFTLSHG---------WAPGSLLTYSCPQGLYP-SPASRLCKSSG 68 + P C S +F L HG + + + +SC G + PAS C +G Sbjct: 2644 NKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNG 2703 Query: 69 QWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPV 128 W + C+ + C + NG SY G F C+ GF+L GS V Sbjct: 2704 TWSWRN-----ERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAV 2756 Query: 129 RQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE 188 R+C +G+W C AGHC P + + G +G+ D V Y+C+ L GSS Sbjct: 2757 RECLSSGLWSESETRCL--AGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSV 2814 Query: 189 RECQGNGVWSGTEPIC 204 R CQ + WSG P C Sbjct: 2815 RICQQDHNWSGQLPSC 2830 Score = 80.5 bits (197), Expect = 5e-15 Identities = 61/186 (32%), Positives = 79/186 (42%), Gaps = 24/186 (12%) Query: 30 ISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVR 88 I G TF+ S + YSC +G + P+ R C ++G W S + C + Sbjct: 3088 IDGTTFSSS--------VIYSCMEGYILSGPSVRQCTANGTW-------SGTLPNCTIIS 3132 Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFI--LRGSPVRQCRPNGMWDGETAVCD 145 C P NG+ R G Y VG NVS+ C+ G+ L GS +R C NG W G C Sbjct: 3133 CGDPGIPANGL---RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3189 Query: 146 NGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205 A CP P G F G + Y CS L+ + C GNG WSG P C Sbjct: 3190 --AVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL 3247 Query: 206 QPYSYD 211 + D Sbjct: 3248 PKFCGD 3253 Score = 77.4 bits (189), Expect = 4e-14 Identities = 59/188 (31%), Positives = 80/188 (42%), Gaps = 22/188 (11%) Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCP-QGLYPSPASRLCKSSGQWQTPGATRSLS 80 P P N +SG +T GS + YSC + +SR C+ +G W S S Sbjct: 2958 PGVPPNAVLSGEKYTF------GSTVHYSCTGKRSLLGQSSRTCQLNGHW-------SGS 3004 Query: 81 KAVCK---PVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMW 137 + C C P + +G + + ++ V + C+ G+IL GS R C NG W Sbjct: 3005 QPHCSGDATGTCGDPGTPGHG--SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSW 3062 Query: 138 DGETAVCDNGAGHCPNPGISL-GAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV 196 G C A C NPG + G V V Y C +L+G S R+C NG Sbjct: 3063 TGRQPECK--AVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT 3120 Query: 197 WSGTEPIC 204 WSGT P C Sbjct: 3121 WSGTLPNC 3128 Score = 71.6 bits (174), Expect = 2e-12 Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 12/163 (7%) Query: 44 GSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102 GS ++C G + A R C SSG W S S+ C C P NG Sbjct: 2738 GSTAIFTCDLGFMLVGSAVRECLSSGLW-------SESETRCLAGHCGIPELIVNGQVIG 2790 Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162 +Y V ++C GF L GS VR C+ + W G+ C + C +PG + Sbjct: 2791 E--NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS--CGHPGSPIYGRT 2846 Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205 +G F D V + C+ ++ G ++ +CQ N WS P+C+ Sbjct: 2847 SGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2889 Score = 67.0 bits (162), Expect = 6e-11 Identities = 56/172 (32%), Positives = 75/172 (43%), Gaps = 24/172 (13%) Query: 60 ASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFEN-GIYTPRLGS------YPVGGN 112 ++R+C++ G W S S C P S EN G+ PR GS + VG Sbjct: 3287 STRICQADGTW-------SGSSPHCIE---PTQTSCENPGV--PRHGSQNNTFGFQVGSV 3334 Query: 113 VSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRF-GHGD 171 V F C+ G +L+GS R C P+ W G C + C P A G HG Sbjct: 3335 VQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHS--CKQPETPAHANVVGMDLPSHGY 3392 Query: 172 KVRYRCSSNLVLTGSSE-RECQGNGVWSGTEPICRQPYSYDFPEDVAPALGT 222 + Y C L G +E R C+ + W+G PIC + S +D PALGT Sbjct: 3393 TLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC-EAGSKILVKDPRPALGT 3443 Score = 49.3 bits (116), Expect = 1e-05 Identities = 26/56 (46%), Positives = 30/56 (53%), Gaps = 2/56 (3%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNG--VWSGTEPIC 204 C +PGI R GF FG GD + + CSS L G+SE C G G VWS P C Sbjct: 1142 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1197 Score = 47.8 bits (112), Expect = 4e-05 Identities = 24/59 (40%), Positives = 29/59 (49%), Gaps = 4/59 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV----WSGTEPICR 205 C NPG+ V G RF GDK+RY C + +L G + C N V W PICR Sbjct: 138 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196 Score = 46.6 bits (109), Expect = 9e-05 Identities = 24/79 (30%), Positives = 32/79 (40%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSY 210 C +PG L +R G F + D +R+ C L G CQ N WS PIC P Sbjct: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683 Query: 211 DFPEDVAPALGTSFSHMLG 229 +F + L + G Sbjct: 684 NFTAPMGTVLSPDYPEGYG 702 Score = 46.6 bits (109), Expect = 9e-05 Identities = 47/202 (23%), Positives = 73/202 (36%), Gaps = 23/202 (11%) Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT-GSSEREC---QGNGVWSGTEP 202 G CP+PGI + A R G F G + C + T G+ C G +WSG P Sbjct: 790 GHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIP 849 Query: 203 ICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCS 262 C P F L + K+SL + I+ ++ + + Sbjct: 850 KCGAPCGGHFSAPSGVILSPGWPGYY---------KDSLNCEWVIEAEPGHSIKITFERF 900 Query: 263 QSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISS 322 Q+ D L + +L+ + S+ V F+S + + DNSR Sbjct: 901 QTELNYDVLEVHDGPNLLSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSR-------- 951 Query: 323 LENANYKDHENGTGTNTYAALN 344 N +K H NTY+ L+ Sbjct: 952 -SNNGFKIHYESVTVNTYSCLD 972 Score = 38.5 bits (88), Expect = 0.023 Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 4/59 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG----NGVWSGTEPICR 205 CP+PG R G F G V++ C + VL G+ CQ WS P+C+ Sbjct: 446 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 504 Score = 35.8 bits (81), Expect = 0.15 Identities = 19/60 (31%), Positives = 25/60 (41%), Gaps = 2/60 (3%) Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV--WSGTEPIC 204 G CP P ++ G R+ GD V ++C L G S C V W+ PIC Sbjct: 2008 GLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067 Score = 34.7 bits (78), Expect = 0.33 Identities = 18/54 (33%), Positives = 23/54 (42%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 C +PGI + R G F G V + C S L+ C+ N WS P C Sbjct: 970 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023 Score = 34.7 bits (78), Expect = 0.33 Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 6/59 (10%) Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRPNGM--WDGETAVC 144 CP P + +GI ++G Y VG VSF+C+ G+ L+G C P + W+ +C Sbjct: 2012 CPEPQTPSSGI---KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067 Score = 34.3 bits (77), Expect = 0.44 Identities = 19/79 (24%), Positives = 29/79 (36%), Gaps = 3/79 (3%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC---QGNGVWSGTEPICRQP 207 C +PG+ + R G GD V ++C L G C + W + P+C P Sbjct: 1488 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1547 Query: 208 YSYDFPEDVAPALGTSFSH 226 + L +F H Sbjct: 1548 CGGNLTGSSGFILSPNFPH 1566 Score = 34.3 bits (77), Expect = 0.44 Identities = 19/61 (31%), Positives = 24/61 (39%), Gaps = 4/61 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICRQ 206 C +PG + R G + G V Y C + VL G S C G W+ P C Sbjct: 1661 CFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1720 Query: 207 P 207 P Sbjct: 1721 P 1721 Score = 32.7 bits (73), Expect = 1.3 Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 4/45 (8%) Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCR 132 CP P ENG R+GS + +G V F C++ ++L+G+ C+ Sbjct: 446 CPDPGEPENG---KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQ 487 Score = 32.3 bits (72), Expect = 1.7 Identities = 39/141 (27%), Positives = 57/141 (40%), Gaps = 18/141 (12%) Query: 103 RLGS-YPVGGNVSFECEDGFILRGSPVRQCR--PNGM--WDGETAVCDNGAGHCPNPGIS 157 R+G+ + VG +V F+C G+IL GS +C PN + W+ C G Sbjct: 1849 RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG-------G 1901 Query: 158 LGAVRTGFRFGHGDKVRYRCSSNLV--LTGSSERECQGNGVWSGTEPICRQPYSYDFPED 215 + R G G Y + N V +T Q V TE YD ++ Sbjct: 1902 ILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDN 1961 Query: 216 VAPAL----GTSFSHMLGATN 232 AP L GT+ H+L +T+ Sbjct: 1962 NAPRLGSYSGTTIPHLLNSTS 1982 Score = 32.3 bits (72), Expect = 1.7 Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 2/43 (4%) Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQC 131 CP P F NG + VG +SFEC G+ L G+ C Sbjct: 2184 CPDPRPFRNGFVIGN--DFTVGQTISFECFPGYTLIGNSALTC 2224 Score = 30.8 bits (68), Expect = 4.8 Identities = 12/39 (30%), Positives = 16/39 (41%) Query: 107 YPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCD 145 + +G VSF C+ G+ L C N W CD Sbjct: 986 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD 1024 >gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sapiens] Length = 3538 Score = 96.3 bits (238), Expect = 9e-20 Identities = 57/172 (33%), Positives = 82/172 (47%), Gaps = 12/172 (6%) Query: 36 TLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVS 94 T +G+ ++T+SC G L P C+++ QW P +CK V C P Sbjct: 2717 TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHP-------PPMCKVVNCSDPGI 2769 Query: 95 FENGIYTPRL--GSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCP 152 N ++ G++ G V ++C G+ L GS V C+PNG WD C C Sbjct: 2770 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI--MIDCG 2827 Query: 153 NPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 +PG+ AV +G ++ G V Y C+ L G S R CQ NG WSG++P C Sbjct: 2828 HPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 2879 Score = 83.2 bits (204), Expect = 8e-16 Identities = 60/186 (32%), Positives = 80/186 (43%), Gaps = 18/186 (9%) Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSP---ASRLCKSSGQWQTPGATRS 78 P P N GG T + G+ +TY C G S + +C+S G W T Sbjct: 2531 PKAPTN----GGILTTDY--LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPR 2584 Query: 79 LSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWD 138 C + C + NG SY G F C+ GF+L GS VR+C +G+W Sbjct: 2585 -----CVVISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGLWS 2637 Query: 139 GETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWS 198 C AGHC P + + G +G+ D V Y+C+ L GSS R CQ + WS Sbjct: 2638 ESETRCL--AGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWS 2695 Query: 199 GTEPIC 204 G P C Sbjct: 2696 GQLPSC 2701 Score = 82.8 bits (203), Expect = 1e-15 Identities = 59/192 (30%), Positives = 77/192 (40%), Gaps = 21/192 (10%) Query: 20 SAPSCPQNVN----ISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRL-CKSSGQWQTPG 74 S P P N I G FT G+++ Y C G + +S L C+ +GQW P Sbjct: 2765 SDPGIPANSKRESKIEHGNFTY------GTVVFYDCNPGYFLFGSSVLICQPNGQWDKP- 2817 Query: 75 ATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPN 134 C + C P N + + Y G V + C L G R C+ N Sbjct: 2818 ------LPECIMIDCGHPGVPPNAVLSGE--KYTFGSTVHYSCTGKRSLLGQSSRTCQLN 2869 Query: 135 GMWDGETAVCDNGA-GHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG 193 G W G C A G C +PG R F VRY C + +L GS ER C Sbjct: 2870 GHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 2929 Query: 194 NGVWSGTEPICR 205 NG W+G +P C+ Sbjct: 2930 NGSWTGRQPECK 2941 Score = 82.4 bits (202), Expect = 1e-15 Identities = 52/167 (31%), Positives = 71/167 (42%), Gaps = 14/167 (8%) Query: 44 GSLLTYSCPQGL---YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIY 100 G ++Y C G R C +G W T C+ V CP P NG Sbjct: 3023 GQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPT-------CRAVTCPTPPQISNGRL 3075 Query: 101 TPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA 160 ++ G ++S+ C G+ L V C NG W GE C C +PGI Sbjct: 3076 EGT--NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL--PKFCGDPGIPAQG 3131 Query: 161 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP 207 R G F + +V + C+ +L GSS R CQ +G WSG+ P C +P Sbjct: 3132 KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEP 3178 Score = 80.5 bits (197), Expect = 5e-15 Identities = 61/186 (32%), Positives = 79/186 (42%), Gaps = 24/186 (12%) Query: 30 ISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVR 88 I G TF+ S + YSC +G + P+ R C ++G W S + C + Sbjct: 2959 IDGTTFSSS--------VIYSCMEGYILSGPSVRQCTANGTW-------SGTLPNCTIIS 3003 Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFI--LRGSPVRQCRPNGMWDGETAVCD 145 C P NG+ R G Y VG NVS+ C+ G+ L GS +R C NG W G C Sbjct: 3004 CGDPGIPANGL---RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3060 Query: 146 NGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205 A CP P G F G + Y CS L+ + C GNG WSG P C Sbjct: 3061 --AVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL 3118 Query: 206 QPYSYD 211 + D Sbjct: 3119 PKFCGD 3124 Score = 77.4 bits (189), Expect = 4e-14 Identities = 59/188 (31%), Positives = 80/188 (42%), Gaps = 22/188 (11%) Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCP-QGLYPSPASRLCKSSGQWQTPGATRSLS 80 P P N +SG +T GS + YSC + +SR C+ +G W S S Sbjct: 2829 PGVPPNAVLSGEKYTF------GSTVHYSCTGKRSLLGQSSRTCQLNGHW-------SGS 2875 Query: 81 KAVCK---PVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMW 137 + C C P + +G + + ++ V + C+ G+IL GS R C NG W Sbjct: 2876 QPHCSGDATGTCGDPGTPGHG--SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSW 2933 Query: 138 DGETAVCDNGAGHCPNPGISL-GAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV 196 G C A C NPG + G V V Y C +L+G S R+C NG Sbjct: 2934 TGRQPECK--AVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT 2991 Query: 197 WSGTEPIC 204 WSGT P C Sbjct: 2992 WSGTLPNC 2999 Score = 71.6 bits (174), Expect = 2e-12 Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 12/163 (7%) Query: 44 GSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102 GS ++C G + A R C SSG W S S+ C C P NG Sbjct: 2609 GSTAIFTCDLGFMLVGSAVRECLSSGLW-------SESETRCLAGHCGIPELIVNGQVIG 2661 Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162 +Y V ++C GF L GS VR C+ + W G+ C + C +PG + Sbjct: 2662 E--NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS--CGHPGSPIYGRT 2717 Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205 +G F D V + C+ ++ G ++ +CQ N WS P+C+ Sbjct: 2718 SGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2760 Score = 67.0 bits (162), Expect = 6e-11 Identities = 56/172 (32%), Positives = 75/172 (43%), Gaps = 24/172 (13%) Query: 60 ASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFEN-GIYTPRLGS------YPVGGN 112 ++R+C++ G W S S C P S EN G+ PR GS + VG Sbjct: 3158 STRICQADGTW-------SGSSPHCIE---PTQTSCENPGV--PRHGSQNNTFGFQVGSV 3205 Query: 113 VSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRF-GHGD 171 V F C+ G +L+GS R C P+ W G C + C P A G HG Sbjct: 3206 VQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHS--CKQPETPAHANVVGMDLPSHGY 3263 Query: 172 KVRYRCSSNLVLTGSSE-RECQGNGVWSGTEPICRQPYSYDFPEDVAPALGT 222 + Y C L G +E R C+ + W+G PIC + S +D PALGT Sbjct: 3264 TLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC-EAGSKILVKDPRPALGT 3314 Score = 49.3 bits (116), Expect = 1e-05 Identities = 26/56 (46%), Positives = 30/56 (53%), Gaps = 2/56 (3%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNG--VWSGTEPIC 204 C +PGI R GF FG GD + + CSS L G+SE C G G VWS P C Sbjct: 1078 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1133 Score = 47.8 bits (112), Expect = 4e-05 Identities = 24/59 (40%), Positives = 29/59 (49%), Gaps = 4/59 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV----WSGTEPICR 205 C NPG+ V G RF GDK+RY C + +L G + C N V W PICR Sbjct: 178 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236 Score = 46.6 bits (109), Expect = 9e-05 Identities = 24/79 (30%), Positives = 32/79 (40%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSY 210 C +PG L +R G F + D +R+ C L G CQ N WS PIC P Sbjct: 560 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 619 Query: 211 DFPEDVAPALGTSFSHMLG 229 +F + L + G Sbjct: 620 NFTAPMGTVLSPDYPEGYG 638 Score = 46.6 bits (109), Expect = 9e-05 Identities = 47/202 (23%), Positives = 73/202 (36%), Gaps = 23/202 (11%) Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT-GSSEREC---QGNGVWSGTEP 202 G CP+PGI + A R G F G + C + T G+ C G +WSG P Sbjct: 726 GHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIP 785 Query: 203 ICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCS 262 C P F L + K+SL + I+ ++ + + Sbjct: 786 KCGAPCGGHFSAPSGVILSPGWPGYY---------KDSLNCEWVIEAEPGHSIKITFERF 836 Query: 263 QSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISS 322 Q+ D L + +L+ + S+ V F+S + + DNSR Sbjct: 837 QTELNYDVLEVHDGPNLLSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSR-------- 887 Query: 323 LENANYKDHENGTGTNTYAALN 344 N +K H NTY+ L+ Sbjct: 888 -SNNGFKIHYESVTVNTYSCLD 908 Score = 38.5 bits (88), Expect = 0.023 Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 4/59 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG----NGVWSGTEPICR 205 CP+PG R G F G V++ C + VL G+ CQ WS P+C+ Sbjct: 382 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 440 Score = 35.8 bits (81), Expect = 0.15 Identities = 19/60 (31%), Positives = 25/60 (41%), Gaps = 2/60 (3%) Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV--WSGTEPIC 204 G CP P ++ G R+ GD V ++C L G S C V W+ PIC Sbjct: 1944 GLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2003 Score = 34.7 bits (78), Expect = 0.33 Identities = 18/54 (33%), Positives = 23/54 (42%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 C +PGI + R G F G V + C S L+ C+ N WS P C Sbjct: 906 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 959 Score = 34.7 bits (78), Expect = 0.33 Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 6/59 (10%) Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRPNGM--WDGETAVC 144 CP P + +GI ++G Y VG VSF+C+ G+ L+G C P + W+ +C Sbjct: 1948 CPEPQTPSSGI---KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2003 Score = 34.3 bits (77), Expect = 0.44 Identities = 19/79 (24%), Positives = 29/79 (36%), Gaps = 3/79 (3%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC---QGNGVWSGTEPICRQP 207 C +PG+ + R G GD V ++C L G C + W + P+C P Sbjct: 1424 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1483 Query: 208 YSYDFPEDVAPALGTSFSH 226 + L +F H Sbjct: 1484 CGGNLTGSSGFILSPNFPH 1502 Score = 34.3 bits (77), Expect = 0.44 Identities = 19/61 (31%), Positives = 24/61 (39%), Gaps = 4/61 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICRQ 206 C +PG + R G + G V Y C + VL G S C G W+ P C Sbjct: 1597 CFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1656 Query: 207 P 207 P Sbjct: 1657 P 1657 Score = 32.7 bits (73), Expect = 1.3 Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 4/45 (8%) Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCR 132 CP P ENG R+GS + +G V F C++ ++L+G+ C+ Sbjct: 382 CPDPGEPENG---KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQ 423 Score = 32.3 bits (72), Expect = 1.7 Identities = 39/141 (27%), Positives = 57/141 (40%), Gaps = 18/141 (12%) Query: 103 RLGS-YPVGGNVSFECEDGFILRGSPVRQCR--PNGM--WDGETAVCDNGAGHCPNPGIS 157 R+G+ + VG +V F+C G+IL GS +C PN + W+ C G Sbjct: 1785 RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG-------G 1837 Query: 158 LGAVRTGFRFGHGDKVRYRCSSNLV--LTGSSERECQGNGVWSGTEPICRQPYSYDFPED 215 + R G G Y + N V +T Q V TE YD ++ Sbjct: 1838 ILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDN 1897 Query: 216 VAPAL----GTSFSHMLGATN 232 AP L GT+ H+L +T+ Sbjct: 1898 NAPRLGSYSGTTIPHLLNSTS 1918 Score = 32.3 bits (72), Expect = 1.7 Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 2/43 (4%) Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQC 131 CP P F NG + VG +SFEC G+ L G+ C Sbjct: 2120 CPDPRPFRNGFVIGN--DFTVGQTISFECFPGYTLIGNSALTC 2160 Score = 30.8 bits (68), Expect = 4.8 Identities = 12/39 (30%), Positives = 16/39 (41%) Query: 107 YPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCD 145 + +G VSF C+ G+ L C N W CD Sbjct: 922 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD 960 >gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens] Length = 3707 Score = 96.3 bits (238), Expect = 9e-20 Identities = 57/172 (33%), Positives = 82/172 (47%), Gaps = 12/172 (6%) Query: 36 TLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVS 94 T +G+ ++T+SC G L P C+++ QW P +CK V C P Sbjct: 2886 TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHP-------PPMCKVVNCSDPGI 2938 Query: 95 FENGIYTPRL--GSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCP 152 N ++ G++ G V ++C G+ L GS V C+PNG WD C C Sbjct: 2939 PANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI--MIDCG 2996 Query: 153 NPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 +PG+ AV +G ++ G V Y C+ L G S R CQ NG WSG++P C Sbjct: 2997 HPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHC 3048 Score = 82.8 bits (203), Expect = 1e-15 Identities = 59/192 (30%), Positives = 77/192 (40%), Gaps = 21/192 (10%) Query: 20 SAPSCPQNVN----ISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRL-CKSSGQWQTPG 74 S P P N I G FT G+++ Y C G + +S L C+ +GQW P Sbjct: 2934 SDPGIPANSKRESKIEHGNFTY------GTVVFYDCNPGYFLFGSSVLICQPNGQWDKP- 2986 Query: 75 ATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPN 134 C + C P N + + Y G V + C L G R C+ N Sbjct: 2987 ------LPECIMIDCGHPGVPPNAVLSGE--KYTFGSTVHYSCTGKRSLLGQSSRTCQLN 3038 Query: 135 GMWDGETAVCDNGA-GHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG 193 G W G C A G C +PG R F VRY C + +L GS ER C Sbjct: 3039 GHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLA 3098 Query: 194 NGVWSGTEPICR 205 NG W+G +P C+ Sbjct: 3099 NGSWTGRQPECK 3110 Score = 82.4 bits (202), Expect = 1e-15 Identities = 52/167 (31%), Positives = 71/167 (42%), Gaps = 14/167 (8%) Query: 44 GSLLTYSCPQGL---YPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIY 100 G ++Y C G R C +G W T C+ V CP P NG Sbjct: 3192 GQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPT-------CRAVTCPTPPQISNGRL 3244 Query: 101 TPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA 160 ++ G ++S+ C G+ L V C NG W GE C C +PGI Sbjct: 3245 EGT--NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL--PKFCGDPGIPAQG 3300 Query: 161 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQP 207 R G F + +V + C+ +L GSS R CQ +G WSG+ P C +P Sbjct: 3301 KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEP 3347 Score = 80.5 bits (197), Expect = 5e-15 Identities = 59/196 (30%), Positives = 83/196 (42%), Gaps = 19/196 (9%) Query: 19 DSAPSCPQNVNISGGTFTLSHG---------WAPGSLLTYSCPQGLYP-SPASRLCKSSG 68 + P C S +F L HG + + + +SC G + PAS C +G Sbjct: 2684 NKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNG 2743 Query: 69 QWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPV 128 W + C+ + C + NG SY G F C+ GF+L GS V Sbjct: 2744 TWSWRN-----ERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAV 2796 Query: 129 RQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE 188 R+C +G+W C AGHC P + + G +G+ D V Y+C+ L GSS Sbjct: 2797 RECLSSGLWSESETRCL--AGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSV 2854 Query: 189 RECQGNGVWSGTEPIC 204 R CQ + WSG P C Sbjct: 2855 RICQQDHNWSGQLPSC 2870 Score = 80.5 bits (197), Expect = 5e-15 Identities = 61/186 (32%), Positives = 79/186 (42%), Gaps = 24/186 (12%) Query: 30 ISGGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVR 88 I G TF+ S + YSC +G + P+ R C ++G W S + C + Sbjct: 3128 IDGTTFSSS--------VIYSCMEGYILSGPSVRQCTANGTW-------SGTLPNCTIIS 3172 Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFI--LRGSPVRQCRPNGMWDGETAVCD 145 C P NG+ R G Y VG NVS+ C+ G+ L GS +R C NG W G C Sbjct: 3173 CGDPGIPANGL---RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3229 Query: 146 NGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205 A CP P G F G + Y CS L+ + C GNG WSG P C Sbjct: 3230 --AVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL 3287 Query: 206 QPYSYD 211 + D Sbjct: 3288 PKFCGD 3293 Score = 77.4 bits (189), Expect = 4e-14 Identities = 59/188 (31%), Positives = 80/188 (42%), Gaps = 22/188 (11%) Query: 22 PSCPQNVNISGGTFTLSHGWAPGSLLTYSCP-QGLYPSPASRLCKSSGQWQTPGATRSLS 80 P P N +SG +T GS + YSC + +SR C+ +G W S S Sbjct: 2998 PGVPPNAVLSGEKYTF------GSTVHYSCTGKRSLLGQSSRTCQLNGHW-------SGS 3044 Query: 81 KAVCK---PVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMW 137 + C C P + +G + + ++ V + C+ G+IL GS R C NG W Sbjct: 3045 QPHCSGDATGTCGDPGTPGHG--SRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSW 3102 Query: 138 DGETAVCDNGAGHCPNPGISL-GAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV 196 G C A C NPG + G V V Y C +L+G S R+C NG Sbjct: 3103 TGRQPECK--AVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT 3160 Query: 197 WSGTEPIC 204 WSGT P C Sbjct: 3161 WSGTLPNC 3168 Score = 71.6 bits (174), Expect = 2e-12 Identities = 48/163 (29%), Positives = 71/163 (43%), Gaps = 12/163 (7%) Query: 44 GSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTP 102 GS ++C G + A R C SSG W S S+ C C P NG Sbjct: 2778 GSTAIFTCDLGFMLVGSAVRECLSSGLW-------SESETRCLAGHCGIPELIVNGQVIG 2830 Query: 103 RLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVR 162 +Y V ++C GF L GS VR C+ + W G+ C + C +PG + Sbjct: 2831 E--NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVS--CGHPGSPIYGRT 2886 Query: 163 TGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205 +G F D V + C+ ++ G ++ +CQ N WS P+C+ Sbjct: 2887 SGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK 2929 Score = 67.0 bits (162), Expect = 6e-11 Identities = 56/172 (32%), Positives = 75/172 (43%), Gaps = 24/172 (13%) Query: 60 ASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFEN-GIYTPRLGS------YPVGGN 112 ++R+C++ G W S S C P S EN G+ PR GS + VG Sbjct: 3327 STRICQADGTW-------SGSSPHCIE---PTQTSCENPGV--PRHGSQNNTFGFQVGSV 3374 Query: 113 VSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRF-GHGD 171 V F C+ G +L+GS R C P+ W G C + C P A G HG Sbjct: 3375 VQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHS--CKQPETPAHANVVGMDLPSHGY 3432 Query: 172 KVRYRCSSNLVLTGSSE-RECQGNGVWSGTEPICRQPYSYDFPEDVAPALGT 222 + Y C L G +E R C+ + W+G PIC + S +D PALGT Sbjct: 3433 TLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC-EAGSKILVKDPRPALGT 3483 Score = 49.3 bits (116), Expect = 1e-05 Identities = 26/56 (46%), Positives = 30/56 (53%), Gaps = 2/56 (3%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNG--VWSGTEPIC 204 C +PGI R GF FG GD + + CSS L G+SE C G G VWS P C Sbjct: 1182 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRC 1237 Score = 47.8 bits (112), Expect = 4e-05 Identities = 24/59 (40%), Positives = 29/59 (49%), Gaps = 4/59 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV----WSGTEPICR 205 C NPG+ V G RF GDK+RY C + +L G + C N V W PICR Sbjct: 178 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236 Score = 46.6 bits (109), Expect = 9e-05 Identities = 24/79 (30%), Positives = 32/79 (40%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSY 210 C +PG L +R G F + D +R+ C L G CQ N WS PIC P Sbjct: 664 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 723 Query: 211 DFPEDVAPALGTSFSHMLG 229 +F + L + G Sbjct: 724 NFTAPMGTVLSPDYPEGYG 742 Score = 46.6 bits (109), Expect = 9e-05 Identities = 47/202 (23%), Positives = 73/202 (36%), Gaps = 23/202 (11%) Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT-GSSEREC---QGNGVWSGTEP 202 G CP+PGI + A R G F G + C + T G+ C G +WSG P Sbjct: 830 GHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIP 889 Query: 203 ICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCS 262 C P F L + K+SL + I+ ++ + + Sbjct: 890 KCGAPCGGHFSAPSGVILSPGWPGYY---------KDSLNCEWVIEAEPGHSIKITFERF 940 Query: 263 QSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISS 322 Q+ D L + +L+ + S+ V F+S + + DNSR Sbjct: 941 QTELNYDVLEVHDGPNLLSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSR-------- 991 Query: 323 LENANYKDHENGTGTNTYAALN 344 N +K H NTY+ L+ Sbjct: 992 -SNNGFKIHYESVTVNTYSCLD 1012 Score = 38.5 bits (88), Expect = 0.023 Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 4/59 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG----NGVWSGTEPICR 205 CP+PG R G F G V++ C + VL G+ CQ WS P+C+ Sbjct: 486 CPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCK 544 Score = 35.8 bits (81), Expect = 0.15 Identities = 19/60 (31%), Positives = 25/60 (41%), Gaps = 2/60 (3%) Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV--WSGTEPIC 204 G CP P ++ G R+ GD V ++C L G S C V W+ PIC Sbjct: 2048 GLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2107 Score = 34.7 bits (78), Expect = 0.33 Identities = 18/54 (33%), Positives = 23/54 (42%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 C +PGI + R G F G V + C S L+ C+ N WS P C Sbjct: 1010 CLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1063 Score = 34.7 bits (78), Expect = 0.33 Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 6/59 (10%) Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRPNGM--WDGETAVC 144 CP P + +GI ++G Y VG VSF+C+ G+ L+G C P + W+ +C Sbjct: 2052 CPEPQTPSSGI---KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2107 Score = 34.3 bits (77), Expect = 0.44 Identities = 19/79 (24%), Positives = 29/79 (36%), Gaps = 3/79 (3%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC---QGNGVWSGTEPICRQP 207 C +PG+ + R G GD V ++C L G C + W + P+C P Sbjct: 1528 CRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAP 1587 Query: 208 YSYDFPEDVAPALGTSFSH 226 + L +F H Sbjct: 1588 CGGNLTGSSGFILSPNFPH 1606 Score = 34.3 bits (77), Expect = 0.44 Identities = 19/61 (31%), Positives = 24/61 (39%), Gaps = 4/61 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICRQ 206 C +PG + R G + G V Y C + VL G S C G W+ P C Sbjct: 1701 CFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1760 Query: 207 P 207 P Sbjct: 1761 P 1761 Score = 32.7 bits (73), Expect = 1.3 Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 4/45 (8%) Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCR 132 CP P ENG R+GS + +G V F C++ ++L+G+ C+ Sbjct: 486 CPDPGEPENG---KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQ 527 Score = 32.3 bits (72), Expect = 1.7 Identities = 39/141 (27%), Positives = 57/141 (40%), Gaps = 18/141 (12%) Query: 103 RLGS-YPVGGNVSFECEDGFILRGSPVRQCR--PNGM--WDGETAVCDNGAGHCPNPGIS 157 R+G+ + VG +V F+C G+IL GS +C PN + W+ C G Sbjct: 1889 RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG-------G 1941 Query: 158 LGAVRTGFRFGHGDKVRYRCSSNLV--LTGSSERECQGNGVWSGTEPICRQPYSYDFPED 215 + R G G Y + N V +T Q V TE YD ++ Sbjct: 1942 ILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDN 2001 Query: 216 VAPAL----GTSFSHMLGATN 232 AP L GT+ H+L +T+ Sbjct: 2002 NAPRLGSYSGTTIPHLLNSTS 2022 Score = 32.3 bits (72), Expect = 1.7 Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 2/43 (4%) Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQC 131 CP P F NG + VG +SFEC G+ L G+ C Sbjct: 2224 CPDPRPFRNGFVIGN--DFTVGQTISFECFPGYTLIGNSALTC 2264 Score = 30.8 bits (68), Expect = 4.8 Identities = 12/39 (30%), Positives = 16/39 (41%) Query: 107 YPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCD 145 + +G VSF C+ G+ L C N W CD Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCD 1064 >gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sapiens] Length = 432 Score = 83.2 bits (204), Expect = 8e-16 Identities = 70/252 (27%), Positives = 105/252 (41%), Gaps = 38/252 (15%) Query: 451 HMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFR 510 H L K T VG A+ + PW V+I+ Q C G+++ WVLTAAHCFR Sbjct: 187 HCLACGKSLKTPRVVGGEEASV---DSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR 243 Query: 511 DGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQK 570 D W+V G K + K +I ++ K N DIAL+KL Sbjct: 244 KHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN---------DIALMKLQFP 294 Query: 571 VKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLK 630 + S RPICLP + EL + P + +K N Sbjct: 295 LTFSGTVRPICLPF------------------FDEEL--TPATPLWIIGWGFTKQNGGKM 334 Query: 631 MGVEWTSCAEVVSQEKTMFPNLTDVRE-VVTDQFLCSGTQE-DESPCKGESGGAVFLERR 688 + + +V+ + N D + VT++ +C+G E C+G+SGG + + Sbjct: 335 SDILLQASVQVIDSTRC---NADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD 391 Query: 689 FRFFQVGLVSWG 700 ++ VG+VSWG Sbjct: 392 -QWHVVGIVSWG 402 >gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sapiens] Length = 437 Score = 83.2 bits (204), Expect = 8e-16 Identities = 70/252 (27%), Positives = 105/252 (41%), Gaps = 38/252 (15%) Query: 451 HMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFR 510 H L K T VG A+ + PW V+I+ Q C G+++ WVLTAAHCFR Sbjct: 192 HCLACGKSLKTPRVVGGEEASV---DSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR 248 Query: 511 DGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQK 570 D W+V G K + K +I ++ K N DIAL+KL Sbjct: 249 KHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN---------DIALMKLQFP 299 Query: 571 VKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLK 630 + S RPICLP + EL + P + +K N Sbjct: 300 LTFSGTVRPICLPF------------------FDEEL--TPATPLWIIGWGFTKQNGGKM 339 Query: 631 MGVEWTSCAEVVSQEKTMFPNLTDVRE-VVTDQFLCSGTQE-DESPCKGESGGAVFLERR 688 + + +V+ + N D + VT++ +C+G E C+G+SGG + + Sbjct: 340 SDILLQASVQVIDSTRC---NADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSD 396 Query: 689 FRFFQVGLVSWG 700 ++ VG+VSWG Sbjct: 397 -QWHVVGIVSWG 407 >gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] Length = 3487 Score = 82.0 bits (201), Expect = 2e-15 Identities = 65/203 (32%), Positives = 91/203 (44%), Gaps = 29/203 (14%) Query: 8 FCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSC-PQGLYPSPASRLCKS 66 FC+L ++ P P + +SG ++T+ G+++ YSC + ++R+C Sbjct: 2768 FCVL-----VSCGHPGSPPHSQMSGDSYTV------GAVVRYSCIGKRTLVGNSTRMCGL 2816 Query: 67 SGQW--QTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLG-SYPVGGNVSFECEDGFIL 123 G W P + + S VC PA +GI RLG S+ G + F CE G +L Sbjct: 2817 DGHWTGSLPHCSGT-SVGVCGDPGIPA-----HGI---RLGDSFDPGTVMRFSCEAGHVL 2867 Query: 124 RGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFG--HGDKVRYRCSSNL 181 RGS R C+ NG W G C G C NPG A R F G + Y C Sbjct: 2868 RGSSERTCQANGSWSGSQPEC--GVISCGNPGTPSNA-RVVFSDGLVFSSSIVYECREGY 2924 Query: 182 VLTGSSERECQGNGVWSGTEPIC 204 TG R C NG W+G++P C Sbjct: 2925 YATGLLSRHCSVNGTWTGSDPEC 2947 Score = 81.6 bits (200), Expect = 2e-15 Identities = 55/160 (34%), Positives = 70/160 (43%), Gaps = 11/160 (6%) Query: 47 LTYSCPQGLYPSPAS-RLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLG 105 + Y C G S R+C+ W G T C V C P S + + Sbjct: 2738 VVYQCNAGFRLIGMSVRICQQDHHWS--GKT-----PFCVLVSCGHPGSPPHSQMSG--D 2788 Query: 106 SYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDN-GAGHCPNPGISLGAVRTG 164 SY VG V + C L G+ R C +G W G C G C +PGI +R G Sbjct: 2789 SYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLG 2848 Query: 165 FRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 F G +R+ C + VL GSSER CQ NG WSG++P C Sbjct: 2849 DSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPEC 2888 Score = 80.5 bits (197), Expect = 5e-15 Identities = 58/188 (30%), Positives = 80/188 (42%), Gaps = 11/188 (5%) Query: 47 LTYSCPQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGS 106 +TY C G Y + R+ S T T + +K VCK + C P NG Sbjct: 2974 VTYQCVPG-YMMESHRVSVLSC---TKDRTWNGTKPVCKALMCKPPPLIPNGKVVG--SD 3027 Query: 107 YPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFR 166 + G +V++ C +G+ L V C NG W GE C C +PG+ R Sbjct: 3028 FMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCF--PVFCGDPGVPSRGRREDRG 3085 Query: 167 FGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALG---TS 223 F + V + C LVL GS R CQ +G WSGT+P C P + P G S Sbjct: 3086 FSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNS 3145 Query: 224 FSHMLGAT 231 + +G+T Sbjct: 3146 QGYQVGST 3153 Score = 77.4 bits (189), Expect = 4e-14 Identities = 46/142 (32%), Positives = 66/142 (46%), Gaps = 11/142 (7%) Query: 64 CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPV-GGNVSFECEDGFI 122 C+++G+W +T + C+ + C NG R+G+ V G F C G+ Sbjct: 2638 CQANGKWSLGDSTPT-----CRIISCGELPIPPNG---HRIGTLSVYGATAIFSCNSGYT 2689 Query: 123 LRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLV 182 L GS VR+C NG+W G C AGHC P + G + + V Y+C++ Sbjct: 2690 LVGSRVRECMANGLWSGSEVRCL--AGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFR 2747 Query: 183 LTGSSERECQGNGVWSGTEPIC 204 L G S R CQ + WSG P C Sbjct: 2748 LIGMSVRICQQDHHWSGKTPFC 2769 Score = 72.8 bits (177), Expect = 1e-12 Identities = 51/198 (25%), Positives = 87/198 (43%), Gaps = 24/198 (12%) Query: 20 SAPSCP-QNVNISGGTFTLSHG------WAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQ 71 S P C +V + G +HG + PG+++ +SC G + + R C+++G W Sbjct: 2823 SLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSW- 2881 Query: 72 TPGATRSLSKAVCKPVRCPAPVSFENG--IYTPRLGSYPVGGNVSFECEDGFILRGSPVR 129 S S+ C + C P + N +++ L ++ +EC +G+ G R Sbjct: 2882 ------SGSQPECGVISCGNPGTPSNARVVFSDGL---VFSSSIVYECREGYYATGLLSR 2932 Query: 130 QCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS--S 187 C NG W G C +C +PGI +R G F + V Y+C ++ S Sbjct: 2933 HCSVNGTWTGSDPECL--VINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVS 2990 Query: 188 ERECQGNGVWSGTEPICR 205 C + W+GT+P+C+ Sbjct: 2991 VLSCTKDRTWNGTKPVCK 3008 Score = 71.2 bits (173), Expect = 3e-12 Identities = 56/201 (27%), Positives = 82/201 (40%), Gaps = 23/201 (11%) Query: 13 LYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLY---PSPASRLCKSSGQ 69 L L+ P P+N + G +T+ G+ YSC +G + + A+ C +G Sbjct: 2525 LCQALSCGLPEAPKNGMVFGKEYTV------GTKAMYSCSEGYHLQAGAEATAECLDTGL 2578 Query: 70 WQTPGATRSLSKAVCKPVRCP--APVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGS 126 W C PV CP + +S E+G + + Y + C+ G+ G Sbjct: 2579 WSNRNVPPQ-----CVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQ 2633 Query: 127 PVRQCRPNGMWD--GETAVCD-NGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVL 183 V +C+ NG W T C G P P R G +G + C+S L Sbjct: 2634 RVIRCQANGKWSLGDSTPTCRIISCGELPIPP---NGHRIGTLSVYGATAIFSCNSGYTL 2690 Query: 184 TGSSERECQGNGVWSGTEPIC 204 GS REC NG+WSG+E C Sbjct: 2691 VGSRVRECMANGLWSGSEVRC 2711 Score = 70.1 bits (170), Expect = 7e-12 Identities = 57/172 (33%), Positives = 74/172 (43%), Gaps = 18/172 (10%) Query: 40 GWAPGSLLTYSC--PQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFEN 97 G++ S +++SC P L SP R C+S G W G S P F Sbjct: 3085 GFSYRSSVSFSCHPPLVLVGSPR-RFCQSDGTWS--GTQPSCIDPTLTTCADPGVPQF-- 3139 Query: 98 GIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNP--- 154 GI G Y VG V F C+ G++L+GS R C PN W G C HC P Sbjct: 3140 GIQNNSQG-YQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDC--VPHHCRQPETP 3196 Query: 155 -GISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE-RECQGNGVWSGTEPIC 204 ++GA+ G + Y C L G SE R C+ +G W+G PIC Sbjct: 3197 THANVGALDLP---SMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPIC 3245 Score = 49.7 bits (117), Expect = 1e-05 Identities = 25/81 (30%), Positives = 34/81 (41%) Query: 149 GHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPY 208 G C +PGI R G RF HGD +++ C L G CQ N WS +P C Sbjct: 519 GSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSC 578 Query: 209 SYDFPEDVAPALGTSFSHMLG 229 ++F L ++ G Sbjct: 579 FFNFTSPSGVVLSPNYPEDYG 599 Score = 44.3 bits (103), Expect = 4e-04 Identities = 26/63 (41%), Positives = 31/63 (49%), Gaps = 4/63 (6%) Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCR--PNGMWDGETAVCDN 146 CP P F NGI R Y VG +V+FEC G+ L G PV C+ N WD C+ Sbjct: 2123 CPDPEPFANGIV--RGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEV 2180 Query: 147 GAG 149 G Sbjct: 2181 PCG 2183 Score = 40.4 bits (93), Expect = 0.006 Identities = 20/55 (36%), Positives = 25/55 (45%) Query: 150 HCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 HC +PGI + R G F G V + C S L+ EC+ N WS P C Sbjct: 866 HCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSC 920 Score = 39.7 bits (91), Expect = 0.010 Identities = 32/116 (27%), Positives = 46/116 (39%), Gaps = 9/116 (7%) Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQC--RPNG--MWDGETAVC 144 C P + +G + + P GG++ F C G+ L G + C P G +W +C Sbjct: 2468 CSLPRAPLHGFILGQTSTQP-GGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLC 2526 Query: 145 DNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE--RECQGNGVWS 198 A C P + G + G K Y CS L +E EC G+WS Sbjct: 2527 Q--ALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWS 2580 Score = 39.3 bits (90), Expect = 0.014 Identities = 20/59 (33%), Positives = 26/59 (44%), Gaps = 4/59 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICR 205 C NPG ++ G F GDKVRY C+ L G + C + + W P CR Sbjct: 139 CGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCR 197 Score = 38.5 bits (88), Expect = 0.023 Identities = 21/63 (33%), Positives = 26/63 (41%), Gaps = 4/63 (6%) Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG----NGVWSGTEP 202 G CP+PGI R G F G V++ C+ L GS C WS P Sbjct: 339 GHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRP 398 Query: 203 ICR 205 +CR Sbjct: 399 VCR 401 Score = 38.1 bits (87), Expect = 0.030 Identities = 18/60 (30%), Positives = 26/60 (43%), Gaps = 2/60 (3%) Query: 147 GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV--WSGTEPIC 204 G CP P + V+TG R+ D V ++C L G + C V W+ P+C Sbjct: 1905 GLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC 1964 Score = 37.0 bits (84), Expect = 0.067 Identities = 18/35 (51%), Positives = 22/35 (62%), Gaps = 1/35 (2%) Query: 100 YTPRLGS-YPVGGNVSFECEDGFILRGSPVRQCRP 133 Y RLGS + VG V FEC G+ L+GSP +C P Sbjct: 1743 YGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLP 1777 Score = 36.6 bits (83), Expect = 0.088 Identities = 20/67 (29%), Positives = 28/67 (41%), Gaps = 3/67 (4%) Query: 148 AGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC---QGNGVWSGTEPIC 204 A C +PGI R+G + GD ++C L GS+E C + W + P C Sbjct: 1382 ATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTC 1441 Query: 205 RQPYSYD 211 P D Sbjct: 1442 IAPCGGD 1448 Score = 35.8 bits (81), Expect = 0.15 Identities = 19/67 (28%), Positives = 25/67 (37%), Gaps = 4/67 (5%) Query: 145 DNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGT 200 +N C +PG R G G V Y C + G+S C G VW+ Sbjct: 1552 ENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNP 1611 Query: 201 EPICRQP 207 P+C P Sbjct: 1612 RPVCTAP 1618 Score = 35.4 bits (80), Expect = 0.20 Identities = 17/56 (30%), Positives = 26/56 (46%), Gaps = 2/56 (3%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQG--NGVWSGTEPIC 204 C P + ++R G +FG GD + + C L G++ C G +WS P C Sbjct: 1039 CEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRC 1094 Score = 35.0 bits (79), Expect = 0.26 Identities = 20/58 (34%), Positives = 27/58 (46%), Gaps = 4/58 (6%) Query: 89 CPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGM--WDGETAVC 144 CP P NG+ T Y V VSF+CE G+ L+G C P + W+ +C Sbjct: 1909 CPEPAVPSNGVKTGE--RYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC 1964 Score = 34.3 bits (77), Expect = 0.44 Identities = 29/92 (31%), Positives = 35/92 (38%), Gaps = 5/92 (5%) Query: 162 RTGFRFGHGDKVRYRCSSNLVLTGSSEREC----QGNGVWSGTEPICRQPYSYDFPEDVA 217 R G F G VR+ C+S L GS E EC W+ + P C P + E Sbjct: 1746 RLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRG 1805 Query: 218 PALGTSFSH-MLGATNPTQKTKESLGRKIQIQ 248 L F L + N K G IQIQ Sbjct: 1806 TILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQ 1837 Score = 32.3 bits (72), Expect = 1.7 Identities = 17/67 (25%), Positives = 28/67 (41%), Gaps = 5/67 (7%) Query: 88 RCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNG--MWDGETAVCD 145 +CP P N + +G V + C GF L G+ + C+ ++G +C+ Sbjct: 2293 KCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICE 2352 Query: 146 NGAGHCP 152 HCP Sbjct: 2353 ---VHCP 2356 Score = 31.6 bits (70), Expect = 2.8 Identities = 12/37 (32%), Positives = 17/37 (45%) Query: 109 VGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCD 145 VG V+F C+ G+ L +C PN W C+ Sbjct: 885 VGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCE 921 Score = 31.2 bits (69), Expect = 3.7 Identities = 37/173 (21%), Positives = 63/173 (36%), Gaps = 13/173 (7%) Query: 136 MWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQ--G 193 +WD + CP+P + G + G V + C LTG CQ Sbjct: 2108 VWDLDPGCEAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGT 2167 Query: 194 NGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGR-KIQIQRSGH 252 N W P C P ++ + GT +S G +P +++ + + I Sbjct: 2168 NRNWDHPLPKCEVPCG----GNITSSNGTVYSP--GFPSPYSSSQDCVWLITVPIGHGVR 2221 Query: 253 LNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVL 305 LNL LL Q+ DF+ + R+ F +++ + +S +L Sbjct: 2222 LNLSLL----QTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLL 2270 Score = 30.8 bits (68), Expect = 4.8 Identities = 17/61 (27%), Positives = 26/61 (42%), Gaps = 4/61 (6%) Query: 151 CPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT-GSSEREC---QGNGVWSGTEPICRQ 206 CP+PG+ + R G G + + C + T GS C +G+ VW+ C Sbjct: 691 CPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAVLRCEA 750 Query: 207 P 207 P Sbjct: 751 P 751 Score = 30.4 bits (67), Expect = 6.3 Identities = 21/58 (36%), Positives = 24/58 (41%), Gaps = 4/58 (6%) Query: 151 CPNPGISLGA--VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGV--WSGTEPIC 204 CP P I A V F GD VRYRC L G+ C+ + G PIC Sbjct: 2294 CPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPIC 2351 Score = 30.0 bits (66), Expect = 8.2 Identities = 18/44 (40%), Positives = 24/44 (54%), Gaps = 4/44 (9%) Query: 89 CPAPVSFENGIYTPRLGS-YPVGGNVSFECEDGFILRGSPVRQC 131 CP P E G RLGS + +G +V F C +G+ L+GS C Sbjct: 343 CPDPGIPERG---KRLGSDFRLGSSVQFTCNEGYDLQGSKRITC 383 >gi|205360905 testis-specific serine protease 1 [Homo sapiens] Length = 318 Score = 81.6 bits (200), Expect = 2e-15 Identities = 62/248 (25%), Positives = 110/248 (44%), Gaps = 56/248 (22%) Query: 473 SDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQ---- 528 S + R PW +++ + + C G+L+S +WVL+AAHCF+ S W V +G+ S+ Sbjct: 61 SARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWTVQLGELTSRPTPW 120 Query: 529 ----WGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICL-- 582 + + ++ +++P G+L +DIALL+LA V + + +PIC+ Sbjct: 121 NLRAYSSRYKVQDIIVNP-------DALGVLR---NDIALLRLASSVTYNAYIQPICIES 170 Query: 583 --------PCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVE 634 P L P G+ N L +++ I + Sbjct: 171 STFNFVHRPDCWVTGWGLISPSGTPLPPPYN--------------LREAQVTI-----LN 211 Query: 635 WTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDE-SPCKGESGGAVFLERRFRFFQ 693 T C + Q + R ++ D C+G ++ CKG+SGG + ++ ++Q Sbjct: 212 NTRCNYLFEQPSS--------RSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQ 263 Query: 694 VGLVSWGL 701 VG+VSWG+ Sbjct: 264 VGIVSWGM 271 >gi|148231605 ovochymase 2 [Homo sapiens] Length = 564 Score = 81.6 bits (200), Expect = 2e-15 Identities = 74/271 (27%), Positives = 118/271 (43%), Gaps = 42/271 (15%) Query: 479 PWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGD---PKSQWGKEFL- 534 PW V++K + + C G+++S QWV+TAAHC + N S V G+ ++ G++ L Sbjct: 64 PWQVSLKQRQKHICGGSIVSPQWVITAAHCIANRNIVSTLNVTAGEYDLSQTDPGEQTLT 123 Query: 535 IEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRR 594 IE +I P F KK DIALLK+A + PICLP L + Sbjct: 124 IETVIIHPHFS--TKKPMDY------DIALLKMAGAFQFGHFVGPICLP-----ELREQF 170 Query: 595 PQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTD 654 G C L + V L+ +NL + + W C + LT Sbjct: 171 EAGFICTTAGWGRLTEGGV------LSQVLQEVNLPI-LTWEECVAAL---------LTL 214 Query: 655 VREVVTDQFLCSGTQE-DESPCKGESGGAVFL-ERRFRFFQVGLVSWGLYNPCLGSADKN 712 R + FLC+G + C+G+SGG++ ++ + G+ SWGL + Sbjct: 215 KRPISGKTFLCTGFPDGGRDACQGDSGGSLMCRNKKGAWTLAGVTSWGL------GCGRG 268 Query: 713 SRKRAPRSKVPPPRDFHINLFRMQPWLRQHL 743 R +S P F ++ ++ PW+ +H+ Sbjct: 269 WRNNVRKSDQGSPGIF-TDISKVLPWIHEHI 298 >gi|187960042 selectin E precursor [Homo sapiens] Length = 610 Score = 80.1 bits (196), Expect = 7e-15 Identities = 57/193 (29%), Positives = 81/193 (41%), Gaps = 25/193 (12%) Query: 25 PQNVNIS-----GGTFTLSHGWAPGSLLTYSCPQG-LYPSPASRLCKSSGQWQTPGATRS 78 PQN ++ G FT S ++C +G + PA C + GQW T+ Sbjct: 310 PQNGSVRCSHSPAGEFTFK------SSCNFTCEEGFMLQGPAQVECTTQGQW-----TQQ 358 Query: 79 LSKAVCKPVRCPAPVSFENGIYT---PRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNG 135 + VC+ +C A + E G GS+ G + F CE GF+L+GS QC P G Sbjct: 359 IP--VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTG 416 Query: 136 MWDGETAVCDN---GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQ 192 WD E C+ A H P G+ A F + + C L GS++ EC Sbjct: 417 EWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECT 476 Query: 193 GNGVWSGTEPICR 205 G W+ P C+ Sbjct: 477 SQGQWTEEVPSCQ 489 Score = 76.3 bits (186), Expect = 1e-13 Identities = 56/200 (28%), Positives = 78/200 (39%), Gaps = 22/200 (11%) Query: 20 SAPSCPQNVNISG------GTFTLSH---GWAPGSLLTYSCPQGLYPSPASRL-CKSSGQ 69 S C Q VN + G+ SH ++ S + SC +G PS + C SSG+ Sbjct: 170 SGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE 229 Query: 70 WQTPGATRSLSKAVCKPVRCPAPVSFENGIYT--PRLGSYPVGGNVSFECEDGFILRGSP 127 W P C V C A + NG GS+P +F+CE+GF L G+ Sbjct: 230 WSAP-------IPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ 282 Query: 128 VRQCRPNGMWDGETAVCDN---GAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT 184 QC +G WD E C A P G + F + C +L Sbjct: 283 SLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQ 342 Query: 185 GSSERECQGNGVWSGTEPIC 204 G ++ EC G W+ P+C Sbjct: 343 GPAQVECTTQGQWTQQIPVC 362 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/177 (28%), Positives = 70/177 (39%), Gaps = 18/177 (10%) Query: 44 GSLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPA----PVSFENG 98 GS +SC QG + RL C +G+W K C+ VRC A P Sbjct: 391 GSSCEFSCEQGFVLKGSKRLQCGPTGEWDN-------EKPTCEAVRCDAVHQPPKGLVRC 443 Query: 99 IYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISL 158 ++P +G + + +F CE+GF L GS +C G W E C C + + Sbjct: 444 AHSP-IGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQ--VVKCSSLAVP- 499 Query: 159 GAVRTGFRFG--HGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFP 213 G + G ++ C L GS+ R C G WSG P C P + P Sbjct: 500 GKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIP 556 Score = 45.4 bits (106), Expect = 2e-04 Identities = 31/133 (23%), Positives = 48/133 (36%), Gaps = 24/133 (18%) Query: 87 VRCPAPVSFENG--IYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVC 144 V C A S E+G + + LG++ + S C+ G++ QC +G W C Sbjct: 178 VNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC 237 Query: 145 D-----------NGAGHC-PNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQ 192 + NG C NPG F + C L G+ +C Sbjct: 238 NVVECDAVTNPANGFVECFQNPG----------SFPWNTTCTFDCEEGFELMGAQSLQCT 287 Query: 193 GNGVWSGTEPICR 205 +G W +P C+ Sbjct: 288 SSGNWDNEKPTCK 300 >gi|23957702 transmembrane protease, serine 6 [Homo sapiens] Length = 811 Score = 78.2 bits (191), Expect = 3e-14 Identities = 72/252 (28%), Positives = 117/252 (46%), Gaps = 47/252 (18%) Query: 463 CGVGNMSAN-----ASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHS- 516 CG+ S+ S + PW +++ + + C GALI+D+WV+TAAHCF++ + S Sbjct: 568 CGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMAST 627 Query: 517 -LWRVNVGD--PKSQWGKE--FLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKV 571 LW V +G S+W E F + + ++ P + + + D+ALL+L V Sbjct: 628 VLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEE---------DSHDYDVALLQLDHPV 678 Query: 572 KMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKM 631 S RP+CLP A P G C L + ++ + K+++ L Sbjct: 679 VRSAAVRPVCLP----ARSHFFEP-GLHCWITGWGALREGGPISNAL----QKVDVQL-- 727 Query: 632 GVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQE-DESPCKGESGGAVFLER-RF 689 + C+EV R VT + LC+G ++ + C+G+SGG + + Sbjct: 728 -IPQDLCSEV-------------YRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSG 773 Query: 690 RFFQVGLVSWGL 701 R+F GLVSWGL Sbjct: 774 RWFLAGLVSWGL 785 >gi|157419154 selectin P precursor [Homo sapiens] Length = 830 Score = 76.6 bits (187), Expect = 8e-14 Identities = 52/170 (30%), Positives = 71/170 (41%), Gaps = 10/170 (5%) Query: 44 GSLLTYSCPQGL-YPSPASRLCKSSGQWQ-TPGATRSLSKAVCKPVRCPAPVSFENGIYT 101 GS +SC G P + C +SG+W TP + ++ V+CPA + G Sbjct: 595 GSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMY 654 Query: 102 PRLGSYPVGGNVS--FECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCP----NPG 155 R G N + F C GF L G CRP+G W T C A C N Sbjct: 655 CRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACR--AVKCSELHVNKP 712 Query: 156 ISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205 I++ F +G + C +L GS++ CQ NG WS T P C+ Sbjct: 713 IAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762 Score = 68.9 bits (167), Expect = 2e-11 Identities = 55/199 (27%), Positives = 78/199 (39%), Gaps = 15/199 (7%) Query: 15 PGLADSAPSCPQNVNISGGTFTLSH---GWAPGSLLTYSCPQGLYPSPASRL-CKSSGQW 70 P A C S GT H +A GS + C G L C SG W Sbjct: 315 PAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHW 374 Query: 71 QTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQ 130 P T C+P+ P S + +P L ++ N SF C +GF+LRG+ + + Sbjct: 375 SAPLPT--CEAISCEPLESPVHGSMD---CSPSLRAFQYDTNCSFRCAEGFMLRGADIVR 429 Query: 131 CRPNGMWDGETAVCDNGAGHCPN-PGISLGAVRTGFRFG---HGDKVRYRCSSNLVLTGS 186 C G W VC A C + P + V FG + + C+ L+L G+ Sbjct: 430 CDNLGQWTAPAPVCQ--ALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGA 487 Query: 187 SERECQGNGVWSGTEPICR 205 S +C G W+ P C+ Sbjct: 488 SVLQCLATGNWNSVPPECQ 506 Score = 68.9 bits (167), Expect = 2e-11 Identities = 53/185 (28%), Positives = 76/185 (41%), Gaps = 16/185 (8%) Query: 45 SLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYT-- 101 S+ +++C +GL AS L C ++G W + C+ + C +S +NG T Sbjct: 472 SVCSFTCNEGLLLVGASVLQCLATGNWNSVPPE-------CQAIPCTPLLSPQNGTMTCV 524 Query: 102 PRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGI----S 157 LGS F C++G+ L G C +G W +C+ A CP S Sbjct: 525 QPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCE--AIKCPELFAPEQGS 582 Query: 158 LGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVA 217 L T F G + C + L G + EC +G WS T P C+ S P Sbjct: 583 LDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQC 642 Query: 218 PALGT 222 PAL T Sbjct: 643 PALTT 647 Score = 63.9 bits (154), Expect = 5e-10 Identities = 58/222 (26%), Positives = 85/222 (38%), Gaps = 25/222 (11%) Query: 21 APSCPQNVNISGGTFTLSHG---WAPGSLLTYSCPQGL-YPSPASRLCKSSGQWQTPGAT 76 A CP G T H + S ++SC +G P C +SG W P Sbjct: 259 AAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAP- 317 Query: 77 RSLSKAVCKPVRCP---APVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRP 133 VCK V+C AP P L ++ G + FEC+ G+ +RG + +C Sbjct: 318 ------VCKAVQCQHLEAPSEGTMDCVHP-LTAFAYGSSCKFECQPGYRVRGLDMLRCID 370 Query: 134 NGMWDGETAVCDNGAGHC-----PNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE 188 +G W C+ A C P G S+ + F + +RC+ +L G+ Sbjct: 371 SGHWSAPLPTCE--AISCEPLESPVHG-SMDCSPSLRAFQYDTNCSFRCAEGFMLRGADI 427 Query: 189 RECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGA 230 C G W+ P+C+ D P V + SH GA Sbjct: 428 VRCDNLGQWTAPAPVCQALQCQDLP--VPNEARVNCSHPFGA 467 Score = 57.4 bits (137), Expect = 5e-08 Identities = 48/168 (28%), Positives = 71/168 (42%), Gaps = 18/168 (10%) Query: 45 SLLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYT-- 101 S ++ C G + S+L C +SG W T + L+ A C P++ P E G T Sbjct: 224 SQCSFHCTDGYQVNGPSKLECLASGIW-TNKPPQCLA-AQCPPLKIP-----ERGNMTCL 276 Query: 102 PRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHC-----PNPGI 156 ++ + SF CE+GF L G V QC +G+W VC A C P+ G Sbjct: 277 HSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCK--AVQCQHLEAPSEG- 333 Query: 157 SLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPIC 204 ++ V F +G ++ C + G C +G WS P C Sbjct: 334 TMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTC 381 Score = 55.8 bits (133), Expect = 1e-07 Identities = 27/106 (25%), Positives = 45/106 (42%), Gaps = 6/106 (5%) Query: 104 LGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGI----SLG 159 LG++ SF C DG+ + G +C +G+W + C A CP I ++ Sbjct: 217 LGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCL--AAQCPPLKIPERGNMT 274 Query: 160 AVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICR 205 + + F H + C L G +C +GVW+ P+C+ Sbjct: 275 CLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCK 320 Score = 42.4 bits (98), Expect = 0.002 Identities = 34/130 (26%), Positives = 47/130 (36%), Gaps = 13/130 (10%) Query: 24 CPQNVNISGGTFTLSHGWAPGSL-----LTYSCPQGLYPSPASRL-CKSSGQWQTPGATR 77 CP GT H PG+ + C G S L C+ SGQW T Sbjct: 642 CPALTTPGQGTMYCRHH--PGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTA--VTP 697 Query: 78 SLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMW 137 + C + P++ + G++ G SF C +G +L GS C+ NG W Sbjct: 698 ACRAVKCSELHVNKPIAMN---CSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHW 754 Query: 138 DGETAVCDNG 147 C G Sbjct: 755 STTVPTCQAG 764 >gi|13994276 marapsin [Homo sapiens] Length = 290 Score = 76.3 bits (186), Expect = 1e-13 Identities = 71/260 (27%), Positives = 113/260 (43%), Gaps = 53/260 (20%) Query: 461 TICG----VGNMSANASDQE-RTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDH 515 T CG + M QE PW V+I+ C G+LI++QWVLTAAHCFR+ ++ Sbjct: 24 TACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSET 83 Query: 516 SLWRVNVG-------DPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLA 568 SL++V +G P + + + +E + G A D+AL++L Sbjct: 84 SLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSA------------DVALVELE 131 Query: 569 QKVKMSTHARPICLP---CTMEANL-ALRRPQGSTCRDH---ENELLNKQSVPAHFVALN 621 V + + P+CLP E + GS + E +L K +VP ++ Sbjct: 132 APVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVP----IID 187 Query: 622 GSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQE-DESPCKGESG 680 K N+ ++ E Q KT + + LC+G +E + CKG+SG Sbjct: 188 TPKCNL------LYSKDTEFGYQPKT-----------IKNDMLCAGFEEGKKDACKGDSG 230 Query: 681 GAVFLERRFRFFQVGLVSWG 700 G + + Q G++SWG Sbjct: 231 GPLVCLVGQSWLQAGVISWG 250 >gi|4506115 protein C [Homo sapiens] Length = 461 Score = 74.7 bits (182), Expect = 3e-13 Identities = 68/231 (29%), Positives = 99/231 (42%), Gaps = 38/231 (16%) Query: 478 TPWHVTI-KPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPK--SQWGKEFL 534 +PW V + K + C LI WVLTAAHC D + L R+ D + +W + Sbjct: 223 SPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCM-DESKKLLVRLGEYDLRRWEKWELDLD 281 Query: 535 IEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRR 594 I++ + P + N DIALL LAQ +S PICLP + A L + Sbjct: 282 IKEVFVHPNYSKSTTDN---------DIALLHLAQPATLSQTIVPICLPDSGLAERELNQ 332 Query: 595 PQGSTCRD----HENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFP 650 T H + K++ LN K+ + V C+EV+S Sbjct: 333 AGQETLVTGWGYHSSR--EKEAKRNRTFVLNFIKIPV-----VPHNECSEVMSN------ 379 Query: 651 NLTDVREVVTDQFLCSGTQED-ESPCKGESGGAVFLERRFRFFQVGLVSWG 700 +V++ LC+G D + C+G+SGG + +F VGLVSWG Sbjct: 380 -------MVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWG 423 >gi|32698940 transmembrane protease, serine 12 [Homo sapiens] Length = 348 Score = 74.7 bits (182), Expect = 3e-13 Identities = 62/258 (24%), Positives = 109/258 (42%), Gaps = 50/258 (19%) Query: 458 LTDTICGVGNMSANASDQERTPWHVTIKPKSQET----CRGALISDQWVLTAAHCFRDGN 513 L D + G + + PW V+++ K C G L+ ++WVLTAAHC +D + Sbjct: 69 LKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHCTKDAS 128 Query: 514 DHSLWRVNVG----DPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQ 569 D +W +G + K+ I+ +I P F ILE Y +DIAL L + Sbjct: 129 DPLMWTAVIGTNNIHGRYPHTKKIKIKAIIIHPNF---------ILESYVNDIALFHLKK 179 Query: 570 KVKMSTHARPICLPC----TMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKL 625 V+ + + +PICLP ++ N ++ N Q H+++ Sbjct: 180 AVRYNDYIQPICLPFDVFQILDGNTKCFISGWGRTKEEGNATNILQDAEVHYIS------ 233 Query: 626 NINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDE-SPCKGESGGAV- 683 E+ + E++ ++ + C+G ++ C+G+SGG + Sbjct: 234 -------------REMCNSERS-------YGGIIPNTSFCAGDEDGAFDTCRGDSGGPLM 273 Query: 684 -FLERRFRFFQVGLVSWG 700 +L RFF +G+ S+G Sbjct: 274 CYLPEYKRFFVMGITSYG 291 >gi|4502495 complement component 1, s subcomponent precursor [Homo sapiens] Length = 688 Score = 74.3 bits (181), Expect = 4e-13 Identities = 67/239 (28%), Positives = 100/239 (41%), Gaps = 37/239 (15%) Query: 473 SDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKE 532 +D + PW V GALI++ WVLTAAH + +++ + S+ K Sbjct: 444 ADIKNFPWQVFF---DNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKS 500 Query: 533 FLI--EKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCT----- 585 ++ E I PG+ + + +G F +DIAL++L VKM PICLP T Sbjct: 501 KMLTPEHVFIHPGWKLL-EVPEGRTNF-DNDIALVRLKDPVKMGPTVSPICLPGTSSDYN 558 Query: 586 -MEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQ 644 M+ +L L G T + L +P C EV Sbjct: 559 LMDGDLGLISGWGRTEKRDRAVRLKAARLPV-----------------APLRKCKEV--- 598 Query: 645 EKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLE---RRFRFFQVGLVSWG 700 K P V T +C+G ++ CKG+SGGA ++ + +F+ GLVSWG Sbjct: 599 -KVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWG 656 Score = 39.3 bits (90), Expect = 0.014 Identities = 27/81 (33%), Positives = 36/81 (44%), Gaps = 13/81 (16%) Query: 64 CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENG-IYTPRLGSYPVGGNVSFECEDGFI 122 C+S+G+W S SK C+PV C P S ENG + P S G + + CE+ + Sbjct: 341 CQSNGKW-------SNSKLKCQPVDCGIPESIENGKVEDPE--STLFGSVIRYTCEEPYY 391 Query: 123 LR---GSPVRQCRPNGMWDGE 140 G C NG W E Sbjct: 392 YMENGGGGEYHCAGNGSWVNE 412 Score = 38.5 bits (88), Expect = 0.023 Identities = 33/121 (27%), Positives = 41/121 (33%), Gaps = 11/121 (9%) Query: 86 PVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGF-ILRG-----SPVRQCRPNGMWDG 139 P+ CP + N ++ P Y V C DGF ++ G S C+ NG W Sbjct: 291 PMPCPKEDT-PNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSN 349 Query: 140 ETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT---GSSERECQGNGV 196 C P I G V G +RY C G E C GNG Sbjct: 350 SKLKCQPVDCGIPE-SIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGS 408 Query: 197 W 197 W Sbjct: 409 W 409 >gi|41393602 complement component 1, s subcomponent precursor [Homo sapiens] Length = 688 Score = 74.3 bits (181), Expect = 4e-13 Identities = 67/239 (28%), Positives = 100/239 (41%), Gaps = 37/239 (15%) Query: 473 SDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKE 532 +D + PW V GALI++ WVLTAAH + +++ + S+ K Sbjct: 444 ADIKNFPWQVFF---DNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKS 500 Query: 533 FLI--EKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCT----- 585 ++ E I PG+ + + +G F +DIAL++L VKM PICLP T Sbjct: 501 KMLTPEHVFIHPGWKLL-EVPEGRTNF-DNDIALVRLKDPVKMGPTVSPICLPGTSSDYN 558 Query: 586 -MEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQ 644 M+ +L L G T + L +P C EV Sbjct: 559 LMDGDLGLISGWGRTEKRDRAVRLKAARLPV-----------------APLRKCKEV--- 598 Query: 645 EKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLE---RRFRFFQVGLVSWG 700 K P V T +C+G ++ CKG+SGGA ++ + +F+ GLVSWG Sbjct: 599 -KVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWG 656 Score = 39.3 bits (90), Expect = 0.014 Identities = 27/81 (33%), Positives = 36/81 (44%), Gaps = 13/81 (16%) Query: 64 CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENG-IYTPRLGSYPVGGNVSFECEDGFI 122 C+S+G+W S SK C+PV C P S ENG + P S G + + CE+ + Sbjct: 341 CQSNGKW-------SNSKLKCQPVDCGIPESIENGKVEDPE--STLFGSVIRYTCEEPYY 391 Query: 123 LR---GSPVRQCRPNGMWDGE 140 G C NG W E Sbjct: 392 YMENGGGGEYHCAGNGSWVNE 412 Score = 38.5 bits (88), Expect = 0.023 Identities = 33/121 (27%), Positives = 41/121 (33%), Gaps = 11/121 (9%) Query: 86 PVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGF-ILRG-----SPVRQCRPNGMWDG 139 P+ CP + N ++ P Y V C DGF ++ G S C+ NG W Sbjct: 291 PMPCPKEDT-PNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSN 349 Query: 140 ETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLT---GSSERECQGNGV 196 C P I G V G +RY C G E C GNG Sbjct: 350 SKLKCQPVDCGIPE-SIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGS 408 Query: 197 W 197 W Sbjct: 409 W 409 >gi|4506153 prostasin preproprotein [Homo sapiens] Length = 343 Score = 73.9 bits (180), Expect = 5e-13 Identities = 64/230 (27%), Positives = 105/230 (45%), Gaps = 35/230 (15%) Query: 479 PWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVG----DPKSQWGKEFL 534 PW V+I + C G+L+S+QWVL+AAHCF + + V +G D S+ K Sbjct: 57 PWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVST 116 Query: 535 IEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRR 594 ++ + P + + +QG DIALL+L++ + S + RPICLP AN + Sbjct: 117 LKDIIPHPSY--LQEGSQG-------DIALLQLSRPITFSRYIRPICLPA---ANASF-- 162 Query: 595 PQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGV---EWTSCAEVVSQEKTMFPN 651 P G C + A V+L K L++ + E +C + + Sbjct: 163 PNGLHC------TVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAK------ 210 Query: 652 LTDVREVVTDQFLCSGTQE-DESPCKGESGGAVFLERRFRFFQVGLVSWG 700 + V + +C+G E + C+G+SGG + ++ G+VSWG Sbjct: 211 -PEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWG 259 >gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens] Length = 410 Score = 73.6 bits (179), Expect = 6e-13 Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 33/230 (14%) Query: 476 ERTPWHVTIKPKSQETCRGALISDQWVLTAAHC-FRD-GNDHSLWRV-NVGDPKSQWGKE 532 ++ PW V+++ + C G+LI +WVLTAAHC FR G + W + +G W Sbjct: 172 KKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLAGIGRWDQAWKH- 230 Query: 533 FLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLAL 592 +E + FD FA DIAL LA V S+H +P CLP Sbjct: 231 --LEDIIFPSNFD-FATLT--------SDIALALLAYSVNYSSHIQPACLP-----EKLF 274 Query: 593 RRPQGSTC-RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPN 651 G+ C ++ S P V L ++LNI + C E++ + Sbjct: 275 EVEAGTECWVTGWGQVSESVSGPMPLV-LQETELNI-----MRHEKCCEMLKNKN----- 323 Query: 652 LTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGL 701 ++VT +C + + C+G+SGG + E + QVG+VSWG+ Sbjct: 324 -ISKSKMVTRGTVCGYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGI 372 >gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo sapiens] Length = 410 Score = 73.6 bits (179), Expect = 6e-13 Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 33/230 (14%) Query: 476 ERTPWHVTIKPKSQETCRGALISDQWVLTAAHC-FRD-GNDHSLWRV-NVGDPKSQWGKE 532 ++ PW V+++ + C G+LI +WVLTAAHC FR G + W + +G W Sbjct: 172 KKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLAGIGRWDQAWKH- 230 Query: 533 FLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLAL 592 +E + FD FA DIAL LA V S+H +P CLP Sbjct: 231 --LEDIIFPSNFD-FATLT--------SDIALALLAYSVNYSSHIQPACLP-----EKLF 274 Query: 593 RRPQGSTC-RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPN 651 G+ C ++ S P V L ++LNI + C E++ + Sbjct: 275 EVEAGTECWVTGWGQVSESVSGPMPLV-LQETELNI-----MRHEKCCEMLKNKN----- 323 Query: 652 LTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGL 701 ++VT +C + + C+G+SGG + E + QVG+VSWG+ Sbjct: 324 -ISKSKMVTRGTVCGYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGI 372 >gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo sapiens] Length = 410 Score = 73.6 bits (179), Expect = 6e-13 Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 33/230 (14%) Query: 476 ERTPWHVTIKPKSQETCRGALISDQWVLTAAHC-FRD-GNDHSLWRV-NVGDPKSQWGKE 532 ++ PW V+++ + C G+LI +WVLTAAHC FR G + W + +G W Sbjct: 172 KKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEGGRWLLAGIGRWDQAWKH- 230 Query: 533 FLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLAL 592 +E + FD FA DIAL LA V S+H +P CLP Sbjct: 231 --LEDIIFPSNFD-FATLT--------SDIALALLAYSVNYSSHIQPACLP-----EKLF 274 Query: 593 RRPQGSTC-RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPN 651 G+ C ++ S P V L ++LNI + C E++ + Sbjct: 275 EVEAGTECWVTGWGQVSESVSGPMPLV-LQETELNI-----MRHEKCCEMLKNKN----- 323 Query: 652 LTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGL 701 ++VT +C + + C+G+SGG + E + QVG+VSWG+ Sbjct: 324 -ISKSKMVTRGTVCGYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGI 372 >gi|148806900 epidermis-specific serine protease-like protein [Homo sapiens] Length = 328 Score = 73.6 bits (179), Expect = 6e-13 Identities = 69/253 (27%), Positives = 116/253 (45%), Gaps = 55/253 (21%) Query: 465 VGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFR---DGNDHSLW--R 519 VG A A R PW V++ C G+L+S++ +LTAAHC + +++W Sbjct: 29 VGGQDAAAG---RWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFSYTVWLGS 85 Query: 520 VNVGDPKSQWGKEFLIEKAVISPGF-DVFAKKNQGILEFYGDDIALLKLAQKVKMSTHAR 578 + VGD + + ++ + K VI P + D A D+ALLKL+ +V ++ Sbjct: 86 ITVGDSRKR--VKYYVSKIVIHPKYQDTTA------------DVALLKLSSQVTFTSAIL 131 Query: 579 PICLPCTMEANLAL---------RRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINL 629 PICLP ++ LA+ + + S+ RD+ + L + VP Sbjct: 132 PICLP-SVTKQLAIPPFCWVTGWGKVKESSDRDY-HSALQEAEVPI-------------- 175 Query: 630 KMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSG-TQEDESPCKGESGGAVFLERR 688 ++ +C ++ + P L V+ + +C+G TQ + CKG+SGG + Sbjct: 176 ---IDRQACEQLYNPIGIFLPAL---EPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHID 229 Query: 689 FRFFQVGLVSWGL 701 + Q G+VSWGL Sbjct: 230 GVWIQTGVVSWGL 242 >gi|62912468 complement component 4 binding protein, beta chain isoform 1 precursor [Homo sapiens] Length = 252 Score = 73.2 bits (178), Expect = 8e-13 Identities = 64/236 (27%), Positives = 92/236 (38%), Gaps = 18/236 (7%) Query: 9 CLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLL-TYSCPQGLYPSPASRL-CKS 66 CL+ + A A CP+ + F G +L TY C +G + L C + Sbjct: 8 CLMVAWRVSASDAEHCPELPPVDNSIFVAKE--VEGQILGTYVCIKGYHLVGKKTLFCNA 65 Query: 67 SGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGS 126 S +W + C+ CP PV NG ++ G V ++F C D +IL+GS Sbjct: 66 SKEWDN-------TTTECRLGHCPDPV-LVNGEFSSS-GPVNVSDKITFMCNDHYILKGS 116 Query: 127 PVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS 186 QC + W +C + C PG + G F G + Y C L G Sbjct: 117 NRSQCLEDHTWAPPFPICKSR--DCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGV 174 Query: 187 SERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHML--GATNPTQKTKES 240 E++C +G WS P+C+ PE L S L N Q+ KES Sbjct: 175 QEQQCV-DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKES 229 >gi|62912464 complement component 4 binding protein, beta chain isoform 1 precursor [Homo sapiens] Length = 252 Score = 73.2 bits (178), Expect = 8e-13 Identities = 64/236 (27%), Positives = 92/236 (38%), Gaps = 18/236 (7%) Query: 9 CLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLL-TYSCPQGLYPSPASRL-CKS 66 CL+ + A A CP+ + F G +L TY C +G + L C + Sbjct: 8 CLMVAWRVSASDAEHCPELPPVDNSIFVAKE--VEGQILGTYVCIKGYHLVGKKTLFCNA 65 Query: 67 SGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGS 126 S +W + C+ CP PV NG ++ G V ++F C D +IL+GS Sbjct: 66 SKEWDN-------TTTECRLGHCPDPV-LVNGEFSSS-GPVNVSDKITFMCNDHYILKGS 116 Query: 127 PVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS 186 QC + W +C + C PG + G F G + Y C L G Sbjct: 117 NRSQCLEDHTWAPPFPICKSR--DCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGV 174 Query: 187 SERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHML--GATNPTQKTKES 240 E++C +G WS P+C+ PE L S L N Q+ KES Sbjct: 175 QEQQCV-DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKES 229 >gi|4502505 complement component 4 binding protein, beta chain isoform 1 precursor [Homo sapiens] Length = 252 Score = 73.2 bits (178), Expect = 8e-13 Identities = 64/236 (27%), Positives = 92/236 (38%), Gaps = 18/236 (7%) Query: 9 CLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLL-TYSCPQGLYPSPASRL-CKS 66 CL+ + A A CP+ + F G +L TY C +G + L C + Sbjct: 8 CLMVAWRVSASDAEHCPELPPVDNSIFVAKE--VEGQILGTYVCIKGYHLVGKKTLFCNA 65 Query: 67 SGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGS 126 S +W + C+ CP PV NG ++ G V ++F C D +IL+GS Sbjct: 66 SKEWDN-------TTTECRLGHCPDPV-LVNGEFSSS-GPVNVSDKITFMCNDHYILKGS 116 Query: 127 PVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGS 186 QC + W +C + C PG + G F G + Y C L G Sbjct: 117 NRSQCLEDHTWAPPFPICKSR--DCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGV 174 Query: 187 SERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHML--GATNPTQKTKES 240 E++C +G WS P+C+ PE L S L N Q+ KES Sbjct: 175 QEQQCV-DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKES 229 >gi|187761337 transmembrane protease, serine 11B [Homo sapiens] Length = 416 Score = 73.2 bits (178), Expect = 8e-13 Identities = 78/282 (27%), Positives = 126/282 (44%), Gaps = 81/282 (28%) Query: 452 MLDVSK-----LTDTICG--------VGNMSAN--ASDQERTPWHVTIKPKSQETCRGAL 496 ++++SK LT+ CG GN N +S + PW +++ K + C +L Sbjct: 155 LMEISKAASEMLTNNCCGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASL 214 Query: 497 ISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGIL- 555 IS +W+L+AAHCF N+ W VN G ++ K ++ +K Q I+ Sbjct: 215 ISSRWLLSAAHCFAKKNNSKDWTVNFG---------IVVNKPYMT-------RKVQNIIF 258 Query: 556 -EFYG-----DDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLN 609 E Y DDIAL++LA++V + + R ICLP EA + L +++N ++ Sbjct: 259 HENYSSPGLHDDIALVQLAEEVSFTEYIRKICLP---EAKMKL--------SENDNVVVT 307 Query: 610 KQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVR---------EVVT 660 + +NGS V+ QE F + D + VT Sbjct: 308 GWGT----LYMNGS---------------FPVILQED--FLKIIDNKICNASYAYSGFVT 346 Query: 661 DQFLCSGTQEDES-PCKGESGGAV-FLERRFRFFQVGLVSWG 700 D LC+G E+ C+ +SGG + + + R + VG+VSWG Sbjct: 347 DTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWG 388 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.135 0.421 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 31,016,302 Number of Sequences: 37866 Number of extensions: 1509028 Number of successful extensions: 4490 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 218 Number of HSP's successfully gapped in prelim test: 58 Number of HSP's that attempted gapping in prelim test: 3194 Number of HSP's gapped (non-prelim): 811 length of query: 752 length of database: 18,247,518 effective HSP length: 110 effective length of query: 642 effective length of database: 14,082,258 effective search space: 9040809636 effective search space used: 9040809636 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.