Search of human proteins with 145275172

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]
         (583 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]             1177   0.0  
gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]             1153   0.0  
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]             1105   0.0  
gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]               400   e-111
gi|166295173 kin of IRRE like [Homo sapiens]                          392   e-109
gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens]              385   e-107
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]        114   2e-25
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   114   2e-25
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   111   2e-24
gi|118572606 hemicentin 1 [Homo sapiens]                              110   5e-24
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   102   1e-21
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ...   100   3e-21
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]             99   1e-20
gi|19743806 roundabout 1 isoform b [Homo sapiens]                      96   7e-20
gi|4506569 roundabout 1 isoform a [Homo sapiens]                       96   7e-20
gi|4758822 nephrin precursor [Homo sapiens]                            96   9e-20
gi|21686977 cell adhesion molecule 4 [Homo sapiens]                    94   3e-19
gi|224994173 roundabout 1 isoform d [Homo sapiens]                     92   1e-18
gi|224994171 roundabout 1 isoform c [Homo sapiens]                     92   1e-18
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...    92   1e-18
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ...    92   1e-18
gi|109150416 peroxidasin [Homo sapiens]                                90   5e-18
gi|13489095 sialoadhesin precursor [Homo sapiens]                      90   5e-18
gi|11225258 myelin associated glycoprotein isoform a precursor [...    85   2e-16
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...    84   3e-16
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...    84   3e-16
gi|18104957 myelin associated glycoprotein isoform b precursor [...    84   3e-16
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [...    84   4e-16
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [...    84   4e-16
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [...    84   4e-16

>gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]
          Length = 583

 Score = 1177 bits (3044), Expect = 0.0
 Identities = 583/583 (100%), Positives = 583/583 (100%)

Query: 1   MLRMRVPALLVLLFCFRGRAGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGL 60
           MLRMRVPALLVLLFCFRGRAGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGL
Sbjct: 1   MLRMRVPALLVLLFCFRGRAGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGL 60

Query: 61  RSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGA 120
           RSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGA
Sbjct: 61  RSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGA 120

Query: 121 TFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVT 180
           TFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVT
Sbjct: 121 TFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVT 180

Query: 181 LSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS 240
           LSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS
Sbjct: 181 LSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS 240

Query: 241 CEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 300
           CEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG
Sbjct: 241 CEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 300

Query: 301 AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAF 360
           AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAF
Sbjct: 301 AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAF 360

Query: 361 LRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLH 420
           LRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLH
Sbjct: 361 LRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLH 420

Query: 421 ISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVA 480
           ISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVA
Sbjct: 421 ISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVA 480

Query: 481 LCCWRHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEE 540
           LCCWRHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEE
Sbjct: 481 LCCWRHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEE 540

Query: 541 KGTLETKDPTNGYYKVRGVSPPASPDSRVTSFQWKSPGISNLP 583
           KGTLETKDPTNGYYKVRGVSPPASPDSRVTSFQWKSPGISNLP
Sbjct: 541 KGTLETKDPTNGYYKVRGVSPPASPDSRVTSFQWKSPGISNLP 583


>gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]
          Length = 633

 Score = 1153 bits (2983), Expect = 0.0
 Identities = 583/633 (92%), Positives = 583/633 (92%), Gaps = 50/633 (7%)

Query: 1   MLRMRVPALLVLLFCFRGRAG--------------------------------------- 21
           MLRMRVPALLVLLFCFRGRAG                                       
Sbjct: 1   MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSG 60

Query: 22  -----------WSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL 70
                      WSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL
Sbjct: 61  LALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL 120

Query: 71  VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG 130
           VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG
Sbjct: 121 VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG 180

Query: 131 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE 190
           TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE
Sbjct: 181 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE 240

Query: 191 GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA 250
           GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA
Sbjct: 241 GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA 300

Query: 251 NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL 310
           NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL
Sbjct: 301 NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL 360

Query: 311 RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL 370
           RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL
Sbjct: 361 RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL 420

Query: 371 VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 430
           VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS
Sbjct: 421 VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 480

Query: 431 RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS 490
           RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS
Sbjct: 481 RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS 540

Query: 491 ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT 550
           ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT
Sbjct: 541 ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT 600

Query: 551 NGYYKVRGVSPPASPDSRVTSFQWKSPGISNLP 583
           NGYYKVRGVSPPASPDSRVTSFQWKSPGISNLP
Sbjct: 601 NGYYKVRGVSPPASPDSRVTSFQWKSPGISNLP 633


>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
          Length = 708

 Score = 1105 bits (2857), Expect = 0.0
 Identities = 560/610 (91%), Positives = 560/610 (91%), Gaps = 50/610 (8%)

Query: 1   MLRMRVPALLVLLFCFRGRAG--------------------------------------- 21
           MLRMRVPALLVLLFCFRGRAG                                       
Sbjct: 1   MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSG 60

Query: 22  -----------WSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL 70
                      WSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL
Sbjct: 61  LALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVL 120

Query: 71  VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG 130
           VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG
Sbjct: 121 VPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG 180

Query: 131 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE 190
           TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE
Sbjct: 181 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE 240

Query: 191 GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA 250
           GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA
Sbjct: 241 GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSA 300

Query: 251 NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL 310
           NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL
Sbjct: 301 NRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATL 360

Query: 311 RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL 370
           RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL
Sbjct: 361 RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCL 420

Query: 371 VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 430
           VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS
Sbjct: 421 VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 480

Query: 431 RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS 490
           RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS
Sbjct: 481 RSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKAS 540

Query: 491 ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT 550
           ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT
Sbjct: 541 ASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPT 600

Query: 551 NGYYKVRGVS 560
           NGYYKVRGVS
Sbjct: 601 NGYYKVRGVS 610


>gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]
          Length = 778

 Score =  400 bits (1028), Expect = e-111
 Identities = 229/560 (40%), Positives = 316/560 (56%), Gaps = 30/560 (5%)

Query: 17  RGRAGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAP 76
           R  + + +Y + GN  +G+H L I   EL+D+A YECQA QA +RSRPA+L VLVPP+ P
Sbjct: 91  RDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDP 150

Query: 77  QVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVE 136
            +LGGP +SL AG P NLTC +  +A+P   ++W R G +++GAT+ +TLL++G   S+ 
Sbjct: 151 VILGGPVISLRAGDPLNLTCHA-DNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIV 209

Query: 137 STLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIF 196
           STL ++P   ++G + VCRA ++A+P G++T++T+ +Q+PP V LS  P  V E   V F
Sbjct: 210 STLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTF 269

Query: 197 LCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTAL 256
            C A A P VT YRWAK G  +  A G       D ++ +EPVSCEV+NA+GS N S  +
Sbjct: 270 HCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTV 329

Query: 257 DVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVG 316
           DV FGP +  +P+ + VD+G DA FSCAW GNP   + W +RG   VL +  TL L SV 
Sbjct: 330 DVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVR 389

Query: 317 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPA 376
            EDAG YVCRA     G   G  E  LTVN PP++++  +  A      +++C + ++P 
Sbjct: 390 QEDAGKYVCRAVVPRVG--AGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPP 447

Query: 377 PDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCS 436
           PD + WSW E  LE+G+ GR+ VET    E       G+IS L IS    +DF   +NC+
Sbjct: 448 PDRIAWSWKENVLESGTSGRYTVETISTEE-------GVISTLTISNIVRADFQTIYNCT 500

Query: 437 ARN---------RLGEGGAQ----ASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCC 483
           A N         RL E G++    A L    +   V I   V A    L+++ T VA CC
Sbjct: 501 AWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCC 560

Query: 484 WRHSKASASFSEQKNLMRIP-GSSDGSSSRGPEEEETGSR--EDRGPI----VHTDHSDL 536
            R  +        KN +R+     + +S R  EE  T  +   DRG      V      L
Sbjct: 561 ARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVL 620

Query: 537 VLEEKGTLETKDPTNGYYKV 556
             EEK     KDPTNGYY V
Sbjct: 621 KEEEKEFQNLKDPTNGYYSV 640


>gi|166295173 kin of IRRE like [Homo sapiens]
          Length = 757

 Score =  392 bits (1007), Expect = e-109
 Identities = 220/578 (38%), Positives = 314/578 (54%), Gaps = 28/578 (4%)

Query: 17  RGRAGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAP 76
           +G   W RY + G+A  GQ++L I   EL D+ASYECQAT+A LRSR A+L VL+PPE  
Sbjct: 64  QGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDT 123

Query: 77  QVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVE 136
           ++ GGP + L AG P NLTCR+  +A+P   ++WFRDG   +GA     LLK+G   +  
Sbjct: 124 RIDGGPVILLQAGTPHNLTCRAF-NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTV 182

Query: 137 STLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIF 196
           S L + P   D G  F CR+ ++A+P+G++T+I L + +PP VTLS  P TVQEGE+V+F
Sbjct: 183 SQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVF 242

Query: 197 LCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTAL 256
            CQATA P + GYRWAKGG  +  A   R E   D SF TEPVSCEV N VGS N ST +
Sbjct: 243 TCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLV 302

Query: 257 DVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVG 316
           +V F P +   P+P + D+G D + +C W GNP   +TWT++    VL +   L L SV 
Sbjct: 303 NVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVT 362

Query: 317 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPA 376
             DAG Y CRA     G+     E  L VN PP++++     A      +++C + ++P 
Sbjct: 363 QADAGTYTCRAIVPRIGV--AEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPP 420

Query: 377 PDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCS 436
           PD + W+W E FLE G+  R+ VE       R   G G++S L I+   E+DF   +NC+
Sbjct: 421 PDRIAWAWKENFLEVGTLERYTVE-------RTNSGSGVLSTLTINNVMEADFQTHYNCT 473

Query: 437 ARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQ 496
           A N  G G A   L  R++LP   I      A+  L+     +    +R  K S      
Sbjct: 474 AWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTL 533

Query: 497 KNL-MRIPG-SSDGSSSRGPEEEETGSREDRGPIVHTDHSDL-------------VLEEK 541
           + L +++   + +  +     E++T S      ++   +S                ++ +
Sbjct: 534 RKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTR 593

Query: 542 GTLETKDPTNGYYKVRGVSPPASPDSRVTSF-QWKSPG 578
              E KDPTNGYY VR  +    P SR   +  +++PG
Sbjct: 594 EEYEMKDPTNGYYNVR--AHEDRPSSRAVLYADYRAPG 629


>gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens]
          Length = 600

 Score =  385 bits (988), Expect = e-107
 Identities = 209/507 (41%), Positives = 296/507 (58%), Gaps = 30/507 (5%)

Query: 17  RGRAGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAP 76
           R  + + +Y + GN  +G+H L I   EL+D+A YECQA QA +RSRPA+L VLVPP+ P
Sbjct: 91  RDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDP 150

Query: 77  QVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVE 136
            +LGGP +SL AG P NLTC +  +A+P   ++W R G +++GAT+ +TLL++G   S+ 
Sbjct: 151 VILGGPVISLRAGDPLNLTCHA-DNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIV 209

Query: 137 STLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIF 196
           STL ++P   ++G + VCRA ++A+P G++T++T+ +Q+PP V LS  P  V E   V F
Sbjct: 210 STLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTF 269

Query: 197 LCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTAL 256
            C A A P VT YRWAK G  +  A G       D ++ +EPVSCEV+NA+GS N S  +
Sbjct: 270 HCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTV 329

Query: 257 DVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVG 316
           DV FGP +  +P+ + VD+G DA FSCAW GNP   + W +RG   VL +  TL L SV 
Sbjct: 330 DVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVR 389

Query: 317 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPA 376
            EDAG YVCRA     G   G  E  LTVN PP++++  +  A      +++C + ++P 
Sbjct: 390 QEDAGKYVCRAVVPRVG--AGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPP 447

Query: 377 PDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCS 436
           PD + WSW E  LE+G+ GR+ VET    E       G+IS L IS    +DF   +NC+
Sbjct: 448 PDRIAWSWKENVLESGTSGRYTVETISTEE-------GVISTLTISNIVRADFQTIYNCT 500

Query: 437 ARN---------RLGEGGAQ----ASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCC 483
           A N         RL E G++    A L    +   V I   V A    L+++ T VA CC
Sbjct: 501 AWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCC 560

Query: 484 WRHSKASASFS-------EQKNLMRIP 503
            R  +++   S       E+K  +R+P
Sbjct: 561 ARSQRSTGGRSGISGRGTEKKARLRLP 587


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score =  114 bits (285), Expect = 2e-25
 Identities = 119/403 (29%), Positives = 176/403 (43%), Gaps = 51/403 (12%)

Query: 22  WSRYWISGNAANGQH------DLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEA 75
           W R W    A+ G+        L I  +   D   Y+C A+ A   +R A + +LV  EA
Sbjct: 433 WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR-ASVWLLVR-EA 490

Query: 76  PQV-LGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDG-VLLDGATFHQTLLKEGTPG 133
           PQV +   S     GV   ++C + G   PTP + W R+   L + +  H          
Sbjct: 491 PQVSIHTSSQHFSQGVEVKVSCSASG--YPTPHISWSRESQALQEDSRIHV--------- 539

Query: 134 SVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEK 193
             + TL +   + +D   + C+A ++ + T ++T +TL    PP V+   +   V  GE+
Sbjct: 540 DAQGTLIIQGVAPEDAGNYSCQATNE-VGTDQET-VTLYYTDPPSVSAVNAVVLVAVGEE 597

Query: 194 VIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVADASFLTEPVSCEVSNAVGS 249
            + +C+A+  PP     W +GG  ++    G+   +L + A         +C   N +G 
Sbjct: 598 AVLVCEASGVPPPRVI-WYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGD 656

Query: 250 ANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVL----- 304
           A+    L V   P L   P  V+V++G  A  +C   G P P VTW RRG  Q L     
Sbjct: 657 ASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW-RRGDGQPLGLRLG 715

Query: 305 -GSGATLRLP--------SVGPEDAGDYVCRAEAGLSGLRGGAAEARLTV--NAPPVVTA 353
            G G+  R P        SV PED   YVC A      ++   AEARL V  +APP + +
Sbjct: 716 AGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQ---AEARLIVTGHAPPQIAS 772

Query: 354 LHSAPAFLRG-PARLQCLVFAS-PAPDAVVWSWDEGFLEAGSQ 394
                  L G P  L C+V A  P P+   W  D   L  GS+
Sbjct: 773 SAPTVRVLEGQPVSLPCIVLAGRPLPER-HWLKDGRPLPPGSR 814



 Score =  110 bits (275), Expect = 4e-24
 Identities = 125/454 (27%), Positives = 183/454 (40%), Gaps = 52/454 (11%)

Query: 33  NGQHDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 91
           +G     I      +E +YEC A ++AG     AQ+ V  PP  PQ++  P+V++  G  
Sbjct: 359 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP--PQLVPAPNVTVSPGET 416

Query: 92  ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 151
           A L+CR  G+A     L W RD  +L  +T     L        + +L ++     DG  
Sbjct: 417 AVLSCRVLGEA--PYNLTWVRDWRVLPASTGRVAQL-------ADLSLEISGIIPTDGGR 467

Query: 152 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 211
           + C A S A    R  ++ L ++  P+V++  S     +G +V   C A+   P     W
Sbjct: 468 YQCVA-SNANGVTR-ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY-PTPHISW 524

Query: 212 AKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPI 263
           ++    +      R+ V A  + + + V        SC+ +N VG+   +  L     P 
Sbjct: 525 SRESQAL--QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 582

Query: 264 LQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVL----GSGATLRLPSVGPED 319
           + A    V V VGE+A   C   G P PRV W R G   +L     S   LR+P+    D
Sbjct: 583 VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERD 642

Query: 320 AGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTAL-HSAPAFLRGPARLQCLVFASPAPD 378
           AG Y CRA   ++ L   +AE +L V   P +T L       L   A L C     P P 
Sbjct: 643 AGTYTCRA---VNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP-PP 698

Query: 379 AVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSAR 438
            V W   +G       G         P+S          VL        D    + C AR
Sbjct: 699 TVTWRRGDGQPLGLRLGAGRGSRSRQPDS---------GVLFFESVAPED-QAPYVCEAR 748

Query: 439 NRLGEGGAQASL--------GRRDLLPTVRIVAG 464
           N  G+  A+A L              PTVR++ G
Sbjct: 749 NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEG 782



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 121/440 (27%), Positives = 170/440 (38%), Gaps = 55/440 (12%)

Query: 38   LHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVPANLT 95
            L I   +  D  +Y C+A  + G  S   QL V     APQ+   P  V++  G  A L 
Sbjct: 633  LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV---GHAPQLTELPRDVTVELGRSALLA 689

Query: 96   CRSRGDARPTPELLWFR-DGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 154
            CR+ G  RP P + W R DG  L          +   P S    L     + +D A +VC
Sbjct: 690  CRATG--RPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS--GVLFFESVAPEDQAPYVC 745

Query: 155  RARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG 214
             AR+       +  + ++   PP++  SA    V EG+ V   C   A  P+    W K 
Sbjct: 746  EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 805

Query: 215  GSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPILQA 266
            G P+    G R  + AD S   +          SC  +N  GS +R   L V   P +  
Sbjct: 806  GRPL--PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHP 863

Query: 267  KPEPVSVDVGEDASFSCAWRGNPLPRVTWTR-------RGGAQVLGSGATLRLPSVGPED 319
                   + G  AS  C   G P P +TWT+       RG    +    TL +     +D
Sbjct: 864  TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQD 923

Query: 320  AGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV--TALHSAPAFLRGPAR------LQCLV 371
            AG YVC A    + +   + E RL+VN  P +      +A   L+  A+      L C  
Sbjct: 924  AGAYVCTA---TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEA 980

Query: 372  FASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSR 431
              SP P  V W+ D                 P   +R GL P     L ++  Q  D S 
Sbjct: 981  KGSP-PPLVTWTKDS-------------RPVPPITNRYGLLPS--GSLRLAQVQVGD-SG 1023

Query: 432  SFNCSARNRLGEGGAQASLG 451
             + C+A N  G    +  LG
Sbjct: 1024 HYECTASNPAGSASHRYVLG 1043


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  114 bits (285), Expect = 2e-25
 Identities = 119/403 (29%), Positives = 176/403 (43%), Gaps = 51/403 (12%)

Query: 22  WSRYWISGNAANGQH------DLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEA 75
           W R W    A+ G+        L I  +   D   Y+C A+ A   +R A + +LV  EA
Sbjct: 550 WVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTR-ASVWLLVR-EA 607

Query: 76  PQV-LGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDG-VLLDGATFHQTLLKEGTPG 133
           PQV +   S     GV   ++C + G   PTP + W R+   L + +  H          
Sbjct: 608 PQVSIHTSSQHFSQGVEVKVSCSASG--YPTPHISWSRESQALQEDSRIHV--------- 656

Query: 134 SVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEK 193
             + TL +   + +D   + C+A ++ + T ++T +TL    PP V+   +   V  GE+
Sbjct: 657 DAQGTLIIQGVAPEDAGNYSCQATNE-VGTDQET-VTLYYTDPPSVSAVNAVVLVAVGEE 714

Query: 194 VIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVADASFLTEPVSCEVSNAVGS 249
            + +C+A+  PP     W +GG  ++    G+   +L + A         +C   N +G 
Sbjct: 715 AVLVCEASGVPPPRVI-WYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGD 773

Query: 250 ANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVL----- 304
           A+    L V   P L   P  V+V++G  A  +C   G P P VTW RRG  Q L     
Sbjct: 774 ASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW-RRGDGQPLGLRLG 832

Query: 305 -GSGATLRLP--------SVGPEDAGDYVCRAEAGLSGLRGGAAEARLTV--NAPPVVTA 353
            G G+  R P        SV PED   YVC A      ++   AEARL V  +APP + +
Sbjct: 833 AGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQ---AEARLIVTGHAPPQIAS 889

Query: 354 LHSAPAFLRG-PARLQCLVFAS-PAPDAVVWSWDEGFLEAGSQ 394
                  L G P  L C+V A  P P+   W  D   L  GS+
Sbjct: 890 SAPTVRVLEGQPVSLPCIVLAGRPLPER-HWLKDGRPLPPGSR 931



 Score =  111 bits (277), Expect = 2e-24
 Identities = 128/461 (27%), Positives = 175/461 (37%), Gaps = 62/461 (13%)

Query: 21   GWSRY-WISGNAANGQH-------DLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLV 71
            GW+ Y W  G    G H        LH   ++  D   Y C+A  QAG   R   L VL 
Sbjct: 1346 GWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLT 1405

Query: 72   PPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGT 131
            PP          V  +AG    L C + G   PTP++ W +D   +     H  + ++G 
Sbjct: 1406 PPSVLGAGAAQEVLGLAGADVELQCWTSGV--PTPQVEWTKDRQPVLPGGPHLQVQEDG- 1462

Query: 132  PGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLS--ASPHTVQ 189
                   L +T     D   + C A S A    RD    L +  PP +  S       V 
Sbjct: 1463 -----QVLRITGSHVGDEGRYQCVAFSPAGQQARD--FQLRVHAPPTIWGSNETGEVAVM 1515

Query: 190  EGEKVIFLCQATAQPPVTGYRWAKGGS------PVLGARGPR-LEVVADASFLTEPVSCE 242
            E   V  LC+A   P      W K G+       V+  RG R L++    S      +C+
Sbjct: 1516 EDHLVQLLCEARGVP-TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCK 1574

Query: 243  VSNAVGSANRSTALDVLFGPILQ---AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG 299
             SNAVG+A ++T LDV   P ++    +P  V    G   +  C  RG+P P ++W   G
Sbjct: 1575 ASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG 1634

Query: 300  -------GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP--- 349
                    +++   G+ LRL S G   +G Y C A    S       +  + V  PP   
Sbjct: 1635 LPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS---SPAGEAVLQYSVEVQVPPQLL 1691

Query: 350  VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRG 409
            V   L      +  P  L C    SP P  + W      L+ G          PA E  G
Sbjct: 1692 VAEGLGQVTTIVGQPLELPCQASGSPVP-TIQW------LQNGR---------PAEELAG 1735

Query: 410  GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 450
                   + LHI    E D S  F C A N  G  GA+  +
Sbjct: 1736 VQVASQGTTLHIDHV-ELDHSGLFACQATNEAGTAGAEVEV 1775



 Score =  110 bits (275), Expect = 4e-24
 Identities = 125/454 (27%), Positives = 183/454 (40%), Gaps = 52/454 (11%)

Query: 33  NGQHDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 91
           +G     I      +E +YEC A ++AG     AQ+ V  PP  PQ++  P+V++  G  
Sbjct: 476 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP--PQLVPAPNVTVSPGET 533

Query: 92  ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 151
           A L+CR  G+A     L W RD  +L  +T     L        + +L ++     DG  
Sbjct: 534 AVLSCRVLGEA--PYNLTWVRDWRVLPASTGRVAQL-------ADLSLEISGIIPTDGGR 584

Query: 152 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 211
           + C A S A    R  ++ L ++  P+V++  S     +G +V   C A+   P     W
Sbjct: 585 YQCVA-SNANGVTR-ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY-PTPHISW 641

Query: 212 AKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPI 263
           ++    +      R+ V A  + + + V        SC+ +N VG+   +  L     P 
Sbjct: 642 SRESQAL--QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 699

Query: 264 LQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVL----GSGATLRLPSVGPED 319
           + A    V V VGE+A   C   G P PRV W R G   +L     S   LR+P+    D
Sbjct: 700 VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERD 759

Query: 320 AGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTAL-HSAPAFLRGPARLQCLVFASPAPD 378
           AG Y CRA   ++ L   +AE +L V   P +T L       L   A L C     P P 
Sbjct: 760 AGTYTCRA---VNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP-PP 815

Query: 379 AVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSAR 438
            V W   +G       G         P+S          VL        D    + C AR
Sbjct: 816 TVTWRRGDGQPLGLRLGAGRGSRSRQPDS---------GVLFFESVAPED-QAPYVCEAR 865

Query: 439 NRLGEGGAQASL--------GRRDLLPTVRIVAG 464
           N  G+  A+A L              PTVR++ G
Sbjct: 866 NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEG 899



 Score =  102 bits (253), Expect = 1e-21
 Identities = 115/412 (27%), Positives = 163/412 (39%), Gaps = 61/412 (14%)

Query: 51   YECQA-TQAGLRSRPAQLHVLVPPEA-PQVLGGPSV-SLVAGVPANLTCRSRGDARPTPE 107
            Y C A   AG+    A  HV +  +A P V   PSV   VA     L C + G  RPT  
Sbjct: 3925 YTCSARNSAGV----AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPT-- 3978

Query: 108  LLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDT 167
            + W ++G+ +      Q L     PG     L +   S +D   ++C A++ A      T
Sbjct: 3979 ITWQKEGLNVATGVSTQVL-----PGG---QLRIAHASPEDAGNYLCIAKNSAGSAMGKT 4030

Query: 168  AITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLE 227
             + +  Q PP +       +  EG      C+A   P      W K G PV GA G +  
Sbjct: 4031 RLVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPE-PNITWDKDGQPVSGAEG-KFT 4086

Query: 228  VVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDA 279
            +      L + +        +C   NAVG A R   L +L  P+    P   S+ +G+  
Sbjct: 4087 IQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRL 4146

Query: 280  SFSCAWRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGL 334
               CA RG+P PR+ WT        G      G+TL+  +V  ED+G YVC AE      
Sbjct: 4147 WLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN----- 4201

Query: 335  RGGAAEARLTVNAPPVVTALHSAPAFL----RGPARLQCLVFASPAPDAVVWSWDEGFLE 390
            R G  +A   V+          A ++L     G  +L C+V   P PD + W  D G   
Sbjct: 4202 RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD-IHWIKD-GLPL 4259

Query: 391  AGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLG 442
             GS  R  ++                  L I  T+  D  R + C A N +G
Sbjct: 4260 RGSHLRHQLQN---------------GSLTIHRTERDDAGR-YQCLAENEMG 4295



 Score =  101 bits (252), Expect = 2e-21
 Identities = 107/393 (27%), Positives = 150/393 (38%), Gaps = 59/393 (15%)

Query: 26   WISGNAANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEA--PQVLGGP 82
            W+    +     L I   +L D  SY C A+  AG       L V VPP    P  L GP
Sbjct: 1929 WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGP 1988

Query: 83   SVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVE----ST 138
               ++   P  LTC + G   P+P L+W +DG  +  A         GTPG         
Sbjct: 1989 ---VLVNTPVRLTCNATG--APSPTLMWLKDGNPVSPA---------GTPGLQVFPGGRV 2034

Query: 139  LTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLC 198
            LTL      D   + C A S      +D  + L +  PP +       +V   E V   C
Sbjct: 2035 LTLASARASDSGRYSCVAVSAVGEDRQD--VVLQVHMPPSILGEELNVSVVANESVALEC 2092

Query: 199  QATAQPPVTGYRWAKGGSPVLGARGPRLEV-----------VADASFLTEPVSCEVSNAV 247
            Q+ A PP     W K G P+    G  L             V DA   T    CE  N  
Sbjct: 2093 QSHAMPPPV-LSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYT----CEALNQA 2147

Query: 248  GSANRSTALDVLFGPILQAKPE-PVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS 306
            G + +   L+V   P+   +    ++V  G   S SC  RG P P+++W R+ G  + G 
Sbjct: 2148 GHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISW-RKDGQPLPGE 2206

Query: 307  GATLR-LPSVGP---------EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS 356
            GA L+ + +VG             G Y C      + +   + + +L V+ PP +     
Sbjct: 2207 GAGLQHVSAVGRLLYLGQAQLAQEGTYTCECS---NVVGNSSQDLQLEVHVPPQIAGPRE 2263

Query: 357  APAFLR----GPARLQCLVFASPAPDAVVWSWD 385
             P  +     G A L+C     P P  V W  D
Sbjct: 2264 PPTQVSVVQDGVATLECNATGKP-PPTVTWERD 2295



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 126/433 (29%), Positives = 170/433 (39%), Gaps = 62/433 (14%)

Query: 38   LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L +   E+ D ASY C A  QAG   +   L V VPP     L    V+ +     +L C
Sbjct: 2901 LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAG-LDLEQVTAILNSSVSLPC 2959

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
                 A P PE+ W++D   L  +   +  L  GT      TL L      D   + C A
Sbjct: 2960 DVH--AHPNPEVTWYKDSQAL--SLGEEVFLLPGT-----HTLQLGRARLSDSGMYTCEA 3010

Query: 157  RSQALPTGRD-TAITLSLQYPPEVTLSASPHTVQE------GEKVIFLCQATAQPPVTGY 209
             + A   GRD   + LS+  PP      +P   Q+      G+K +  C+  A P  T  
Sbjct: 3011 LNAA---GRDQKLVQLSVLVPP--AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-V 3064

Query: 210  RWAKGGSPVLGAR-------GPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGP 262
             W K G P++ A+       G RLE+           SC+VSN  G A R+  L V   P
Sbjct: 3065 TWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPP 3124

Query: 263  ILQ-AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTR-------RGGAQVLGSGATLRLPS 314
              +  K E VS   G     +C   G P P VTW +            V+  G  L+L  
Sbjct: 3125 TFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSR 3184

Query: 315  VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPV-VTALHSAPAFLRG-PARLQCLVF 372
            + P  AG Y C AE   +  R     A L   AP +  + +      L G   RL C   
Sbjct: 3185 LQPAQAGTYTCVAENTQAEARKDFVVAVLV--APRIRSSGVAREHHVLEGQEVRLDCEAD 3242

Query: 373  ASPAPDAVVWSWDEGFL--EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 430
              P PD V W  D   L  + G   RF ++        GG        L + G + SD +
Sbjct: 3243 GQPPPD-VAWLKDGSPLGQDMGPHLRFYLD--------GG-------SLVLKGLRASD-A 3285

Query: 431  RSFNCSARNRLGE 443
             ++ C A N  GE
Sbjct: 3286 GAYTCVAHNPAGE 3298



 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 110/392 (28%), Positives = 153/392 (39%), Gaps = 74/392 (18%)

Query: 38   LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSV-SLVAGVPANLT 95
            L +  V++ D   YEC A+  AG  S    L V VPP   QV  GP V  ++ G   +L 
Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPP---QVQPGPRVLKVLVGEALDLN 1140

Query: 96   CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 155
            C + G+  P P+L W +DGV+L G          G  GSV      T     D   + C 
Sbjct: 1141 CVAEGN--PEPQLSWSKDGVVLQG---------RGPQGSVHFAAIRT----SDAGRYRCE 1185

Query: 156  ARSQALPTGRDT-AITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQA--TAQPPVTGYR 210
            A + A   G D   + L +  PP      +   ++   GE     C A  T +P VT   
Sbjct: 1186 ASNSA---GVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVT--- 1239

Query: 211  WAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGP 262
            W KG S       P + V+ + S     VS        C+ +N VGS +R   L V   P
Sbjct: 1240 WRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPP 1299

Query: 263  ILQAKPEPVSVD--VGEDASFSCAWRGNPLPRVTWTRR---------------------- 298
             ++      +V    G+  +  C   G P+P + W +                       
Sbjct: 1300 SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 1359

Query: 299  GGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEA--RLTVNAPPVVTALHS 356
            GG ++L  G +L  P +   D+G Y CRAE      + G A+    L V  PP V    +
Sbjct: 1360 GGHRLLDEGQSLHFPRIQEGDSGLYSCRAEN-----QAGTAQRDFHLLVLTPPSVLGAGA 1414

Query: 357  APAFL---RGPARLQCLVFASPAPDAVVWSWD 385
            A   L        LQC     P P  V W+ D
Sbjct: 1415 AQEVLGLAGADVELQCWTSGVPTPQ-VEWTKD 1445



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 132/499 (26%), Positives = 203/499 (40%), Gaps = 84/499 (16%)

Query: 30   NAANGQHDLHIRPVELEDEAS---YECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS 85
            N +  + D  +  +E   EAS   Y C A+  AG       + V VPP+     G   V+
Sbjct: 1641 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVT 1700

Query: 86   LVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFS 145
             + G P  L C++ G   P P + W ++G   +     Q +  +GT      TL +    
Sbjct: 1701 TIVGQPLELPCQASGS--PVPTIQWLQNGRPAEELAGVQ-VASQGT------TLHIDHVE 1751

Query: 146  HDDGATFVCRARSQALPTGRDTAITLSLQYPP---EVTLSASPHTVQEGEKVIFLCQ--- 199
             D    F C+A ++A   G +  +++  ++ P   EV +       +        C    
Sbjct: 1752 LDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPV 1811

Query: 200  -----ATAQPPVT------GYRWAKG-GSPVLGARGPRLEV----VADASFLTEPVSCEV 243
                 A  +PP+       G  W +  G PV  +  P L++    + D    T    C  
Sbjct: 1812 HRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYT----CAA 1867

Query: 244  SNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDAS--FSCAWRGNPLPRVTWTRRG-- 299
            +N  G + R  AL VL  P ++  P PV+  V E+AS    C   G P P V+W +    
Sbjct: 1868 TNLAGESKREVALKVLVPPNIE--PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQP 1925

Query: 300  -----GAQVLGSGATLRLPSVGPEDAGDYVCRAE--AGLSGLRGGAAEARLTVNAPPVVT 352
                 G  V   G  LR+      DAG Y C A   AG + LR G     L VN PP +T
Sbjct: 1926 VSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-----LRVNVPPRIT 1980

Query: 353  ALHS--APAFLRGPARLQCLVFASPAPDAVVWSWDEGFLE-AGSQGRFLVETFPAPESRG 409
               S   P  +  P RL C    +P+P  ++W  D   +  AG+ G   ++ FP     G
Sbjct: 1981 LPPSLPGPVLVNTPVRLTCNATGAPSP-TLMWLKDGNPVSPAGTPG---LQVFP-----G 2031

Query: 410  GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAAT 469
            G       VL ++  + SD  R ++C A + +GE        R+D++  V +   +    
Sbjct: 2032 G------RVLTLASARASDSGR-YSCVAVSAVGE-------DRQDVVLQVHMPPSILGEE 2077

Query: 470  TTLLMVIT-GVALCCWRHS 487
              + +V    VAL C  H+
Sbjct: 2078 LNVSVVANESVALECQSHA 2096



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 115/445 (25%), Positives = 171/445 (38%), Gaps = 83/445 (18%)

Query: 38   LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPANLT 95
            L++   +L  E +Y C+ +   G  S+  QL V VPP+       P+ VS+V    A L 
Sbjct: 2220 LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 2279

Query: 96   CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 155
            C + G  +P P + W RDG  + GA     L  +G    VE                   
Sbjct: 2280 CNATG--KPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVE------------------- 2317

Query: 156  ARSQALPTGRDTAIT------------LSLQYPPEVTLSASPHT---VQEGEKVIFLCQA 200
             R+QA  TGR + +             LS+  PPE+     P T         +  LC+A
Sbjct: 2318 -RAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEA 2376

Query: 201  TAQPPVTGYRWAKGGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRS 253
               PP    RW +G  PV       L A G  L++       +   SC  SN  G A R+
Sbjct: 2377 MGIPP-PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN 2435

Query: 254  TALDVLFGPILQAKP--EPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLG------ 305
             +++VL  P ++ +   E + V  G+ A   C   G+P P++TW + G     G      
Sbjct: 2436 FSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHIS 2495

Query: 306  -SGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV------TALHSAP 358
              G  L++       AG Y C A    + +       +L+V   P +      +A     
Sbjct: 2496 PDGVLLQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVT 2552

Query: 359  AFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISV 418
              +  P  L C   A P+P+ + W  D    EA    + L      P + G         
Sbjct: 2553 VTVNNPISLICEALAFPSPN-ITWMKDGAPFEASRNIQLL------PGTHG--------- 2596

Query: 419  LHISGTQESDFSRSFNCSARNRLGE 443
            L I   Q+ D +  + C   N LGE
Sbjct: 2597 LQILNAQKED-AGQYTCVVTNELGE 2620



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 94/327 (28%), Positives = 132/327 (40%), Gaps = 30/327 (9%)

Query: 38   LHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVPANLT 95
            L I   +  D  +Y C+A  + G  S   QL V     APQ+   P  V++  G  A L 
Sbjct: 750  LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV---GHAPQLTELPRDVTVELGRSALLA 806

Query: 96   CRSRGDARPTPELLWFR-DGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 154
            CR+ G  RP P + W R DG  L          +   P S    L     + +D A +VC
Sbjct: 807  CRATG--RPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS--GVLFFESVAPEDQAPYVC 862

Query: 155  RARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG 214
             AR+       +  + ++   PP++  SA    V EG+ V   C   A  P+    W K 
Sbjct: 863  EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 922

Query: 215  GSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPILQA 266
            G P+    G R  + AD S   +          SC  +N  GS +R   L V   P +  
Sbjct: 923  GRPL--PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHP 980

Query: 267  KPEPVSVDVGEDASFSCAWRGNPLPRVTWTR-------RGGAQVLGSGATLRLPSVGPED 319
                   + G  AS  C   G P P +TWT+       RG    +    TL +     +D
Sbjct: 981  TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQD 1040

Query: 320  AGDYVCRAEAGLSGLRGGAAEARLTVN 346
            AG YVC A    + +   + E RL+VN
Sbjct: 1041 AGAYVCTA---TNTVGFSSQEMRLSVN 1064



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 110/426 (25%), Positives = 162/426 (38%), Gaps = 59/426 (13%)

Query: 38   LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L +  V   D  +Y C A ++AG   R  QL V+ PP          +SL  G P  L C
Sbjct: 3458 LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLC 3517

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
             ++G   P P + W +DG         Q L +          L +      D   + C A
Sbjct: 3518 DAQGT--PQPNITWHKDG---------QALTRLENNSRATRVLRVR-----DAGLYTCLA 3561

Query: 157  RSQALPTGR-DTAITLSLQYPPEVTLSASPHTVQ--EGEKVIFLCQATAQPPVTGYRWAK 213
             S   P G  + +  + +Q PP +     P  V      +++  C   A+P      W +
Sbjct: 3562 ES---PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEP-APKITWHR 3617

Query: 214  GGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQA 266
             G  +          RG  L++ A ++  +   SC   NA GS + +  +++   P +++
Sbjct: 3618 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 3677

Query: 267  KPEPVSVDVGEDASFSCAWRGNPLPRVTW--------TRRGGAQVLGSGATLRLPSVGPE 318
             P  V+V V + A   C   G P P V+W         R    ++L  G +LR+  V  +
Sbjct: 3678 GPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG-SLRIQPVLAQ 3736

Query: 319  DAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS-APAFLRGPARLQCLVFASPAP 377
            DAG Y+C A       R G     L V  PP +    S        PA L C    SP P
Sbjct: 3737 DAGHYLCLASNSAGSDRQG---RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKP 3793

Query: 378  DAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSA 437
              VVW W +G              F   +    L P    +L   G Q+   S  F C  
Sbjct: 3794 -LVVW-WKDG----------QKLDFRLQQGAYRLLPSNALLLTAPGPQD---SAQFECVV 3838

Query: 438  RNRLGE 443
             N +GE
Sbjct: 3839 SNEVGE 3844



 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 107/409 (26%), Positives = 154/409 (37%), Gaps = 66/409 (16%)

Query: 34   GQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQ--VLGGPSVSLV-AG 89
            G H L I   + ED   Y C  T + G   +   + VL+PP   +   LG   V  V   
Sbjct: 2593 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTK 2652

Query: 90   VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDG 149
            V + LT      A P P + W++DG  +  ++  Q +L EG        L + P    D 
Sbjct: 2653 VNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQ-VLGEG------RLLQIQPTQVSDS 2705

Query: 150  ATFVCRARSQALPTGRDTAITLSLQYPPEV-----------TLSASPHT---------VQ 189
              ++C A + A    +D    + +Q PP              LS              + 
Sbjct: 2706 GRYLCVATNVAGEDDQD--FNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 2763

Query: 190  EGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPV---------S 240
            E       C   A PP     W +   P+  + G  + V+     L  P+         S
Sbjct: 2764 ENNPAYLYCDTNAIPP-PDLTWYREDQPL--SAGDEVSVLQGGRVLQIPLVRAENAGRYS 2820

Query: 241  CEVSNAVGSANRSTALDVLFGPIL----QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWT 296
            C+ SN VG       L VL  P++    +   E V+V+     S  C   GNP+P ++W 
Sbjct: 2821 CKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL 2880

Query: 297  RRG-------GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLT--VNA 347
            + G         QVL  G  L++ +    DA  Y+C AE      + G+AE   T  V  
Sbjct: 2881 QNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAEN-----QAGSAEKLFTLRVQV 2935

Query: 348  PPVVTA--LHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQ 394
            PP +    L    A L     L C V A P P+ V W  D   L  G +
Sbjct: 2936 PPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPE-VTWYKDSQALSLGEE 2983



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 130/481 (27%), Positives = 183/481 (38%), Gaps = 76/481 (15%)

Query: 34   GQHDLHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVP 91
            G   L +      D   Y C A  A G   +   L V +PP    +LG   +VS+VA   
Sbjct: 2031 GGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS---ILGEELNVSVVANES 2087

Query: 92   ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHD-DGA 150
              L C+S   A P P L W++DG  L+         + G   S +  L     +   D  
Sbjct: 2088 VALECQSH--AMPPPVLSWWKDGRPLEP--------RPGVHLSADKALLQVDRADVWDAG 2137

Query: 151  TFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPH-TVQEGEKVIFLCQATAQPPVTGY 209
             + C A +QA  + +     L++   P   L  S   TV+EG      C+    P     
Sbjct: 2138 HYTCEALNQAGHSEKH--YNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVP-FPKI 2194

Query: 210  RWAKGGSPVLGARGP--------RLEVVADASFLTEPV-SCEVSNAVGSANRSTALDVLF 260
             W K G P+ G            RL  +  A    E   +CE SN VG++++   L+V  
Sbjct: 2195 SWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHV 2254

Query: 261  GPILQAKPEP-VSVDVGED--ASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATL 310
             P +    EP   V V +D  A+  C   G P P VTW R G       G Q+   G +L
Sbjct: 2255 PPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSL 2314

Query: 311  RLPSVGPEDAGDYVCRAEAGLSGLRGGA-AEARLTVNAPPVVTA----LHSAPAFLRGPA 365
             +        G Y C AE     L G A  +  L+V  PP +      L +  A L  P 
Sbjct: 2315 HVERAQAAHTGRYSCVAE----NLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPL 2370

Query: 366  RLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQ 425
             L C     P P A+ W   E  +  G     L          GG       +L ++ TQ
Sbjct: 2371 TLLCEAMGIP-PPAIRWFRGEEPVSPGEDTYLLA---------GGW------MLKMTQTQ 2414

Query: 426  ESDFSRSFNCSARNRLGEGG--------AQASLGRRDLLPTVRIVAGVAAATTTLLMVIT 477
            E D S  ++C A N  GE             S+   DL   ++++ G    T  L+  +T
Sbjct: 2415 EQD-SGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDG---QTAHLMCNVT 2470

Query: 478  G 478
            G
Sbjct: 2471 G 2471



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 103/370 (27%), Positives = 137/370 (37%), Gaps = 42/370 (11%)

Query: 38   LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L I  V+L DE  Y C AT  AG   R   L VLVPP      G  + +++      L C
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP--GPVNKAVLENASVTLEC 1907

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLK-EGTPGSVES-TLTLTPFSHDDGATFVC 154
             + G   P P++ WF+          HQ +    G   SV+   L +      D  ++ C
Sbjct: 1908 LASGV--PPPDVSWFKG---------HQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 1956

Query: 155  RARSQALPTGRDTAITLSLQYPPEVTLSAS-PHTVQEGEKVIFLCQATAQPPVTGYRWAK 213
             A + A  T  +    L +  PP +TL  S P  V     V   C AT  P  T   W K
Sbjct: 1957 VASNVAGST--ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLK 2013

Query: 214  GGSPVLGARGPRLEVVADASFLTEP---------VSCEVSNAVGSANRSTALDVLFGPIL 264
             G+PV  A  P L+V      LT            SC   +AVG   +   L V   P +
Sbjct: 2014 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 2073

Query: 265  QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGP 317
              +   VSV   E  +  C     P P ++W + G       G  +    A L++     
Sbjct: 2074 LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADV 2133

Query: 318  EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR--GPARLQCLVFASP 375
             DAG Y C A   L+          L V   PV     S    +R   P  L C     P
Sbjct: 2134 WDAGHYTCEA---LNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVP 2190

Query: 376  APDAVVWSWD 385
             P  + W  D
Sbjct: 2191 FP-KISWRKD 2199



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 114/436 (26%), Positives = 163/436 (37%), Gaps = 60/436 (13%)

Query: 34   GQHDLHIRPVELEDEASYECQATQAGLRSRP-AQLHVLVPPEAPQVLGGP--SVSLVAGV 90
            G H L +    L D   Y C+A  A  R +   QL VLVPP   Q   GP  +V +  G 
Sbjct: 2989 GTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGD 3048

Query: 91   PANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGA 150
             A L+C +  DA P P + W++DG  L  A   Q  L+ G        L +      D  
Sbjct: 3049 KAVLSCET--DALPEPTVTWYKDGQPLVLAQRTQA-LRGG------QRLEIQEAQVSDKG 3099

Query: 151  TFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQATAQPPVTG 208
             + C+  + A    R    TL++Q PP    +    TV +  G  ++  C  +  P  T 
Sbjct: 3100 LYSCKVSNVAGEAVR--TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPT- 3155

Query: 209  YRWAKGGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFG 261
              W K   PV       + +RG RL++           +C   N    A +   + VL  
Sbjct: 3156 VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA 3215

Query: 262  PILQAK--PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG--AQVLG-------SGATL 310
            P +++        V  G++    C   G P P V W + G    Q +G        G +L
Sbjct: 3216 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 3275

Query: 311  RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARL-TVNA---PPVVTALHSAPAFLRGPAR 366
             L  +   DAG Y C A            +ARL TVN    P +      +   +  P  
Sbjct: 3276 VLKGLRASDAGAYTCVAH------NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGE 3329

Query: 367  LQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQE 426
            L  +V        +  SW             L +  P P S+  L  G    L IS  Q 
Sbjct: 3330 LVTMVCPVRGSPPIHVSW-------------LKDGLPLPLSQRTLLHGSGHTLRISKVQL 3376

Query: 427  SDFSRSFNCSARNRLG 442
            +D +  F C A +  G
Sbjct: 3377 AD-AGIFTCVAASPAG 3391



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 102/372 (27%), Positives = 140/372 (37%), Gaps = 51/372 (13%)

Query: 36   HDLHIRPVELEDEASYEC-QATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANL 94
            H L I  V+L D   + C  A+ AG+  R   L V VPP    V     V +V G    L
Sbjct: 3367 HTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVEL 3426

Query: 95   TCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 154
             C +RG   P P + W +DG  L   +  Q             +L L      D  T+ C
Sbjct: 3427 PCEARG--VPLPLVSWMKDGEPLLSQSLEQ-----------GPSLQLEAVGAGDSGTYSC 3473

Query: 155  RARSQALPTGRDTAITLSLQYPPEVTLSASPH--TVQEGEKVIFLC--QATAQPPVTGYR 210
             A S+A    R     L++  PP +  S  P   ++  G  +  LC  Q T QP +T   
Sbjct: 3474 VAVSEAGEARRH--FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--- 3528

Query: 211  WAKGGSPVL----GARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQA 266
            W K G  +      +R  R+  V DA   T    C   +  G+  +S  + V   P +  
Sbjct: 3529 WHKDGQALTRLENNSRATRVLRVRDAGLYT----CLAESPAGAIEKSFRVRVQAPPNIVG 3584

Query: 267  KPEP---VSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVG 316
               P   V +  G+     C+    P P++TW R G         Q    G  L+L ++ 
Sbjct: 3585 PRGPRFVVGLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALS 3643

Query: 317  PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAF---LRGPARLQCLVFA 373
              D+GDY C A         G+      V    V T     PA    +   A L C    
Sbjct: 3644 TADSGDYSCTARNA-----AGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADG 3698

Query: 374  SPAPDAVVWSWD 385
             PAP  V W  D
Sbjct: 3699 VPAP-LVSWRKD 3709



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 116/453 (25%), Positives = 169/453 (37%), Gaps = 90/453 (19%)

Query: 18   GRAGWSRYWI---------SGNAANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQL 67
            GR    R+W+         S ++      LH+     E    Y C AT  AG + R  +L
Sbjct: 911  GRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVEL 970

Query: 68   HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 127
             V VPP           +   GVPA+L C + G   P P + W ++   L     H  + 
Sbjct: 971  VVQVPPRIHPTATHHITN--EGVPASLPCVASGV--PAPTITWTKETNALTSRGPHYNVS 1026

Query: 128  KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 187
            KEGT       L   P + D GA +VC A +          +  S Q   E+ LS +   
Sbjct: 1027 KEGT------LLIAQPSAQDAGA-YVCTATN---------TVGFSSQ---EMRLSVNRLA 1067

Query: 188  VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAV 247
            + +                  Y W + G    G+       V D+        C  SN  
Sbjct: 1068 LSK------------------YVWEEYGLLPSGSLRLAQVQVGDSGHY----ECTASNPA 1105

Query: 248  GSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGA-QVLGS 306
            GSA+    L V   P +Q  P  + V VGE    +C   GNP P+++W++ G   Q  G 
Sbjct: 1106 GSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGP 1165

Query: 307  GATLRLPSVGPEDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR-- 362
              ++   ++   DAG Y C A   AG+      A E  L V  PP   A  ++    R  
Sbjct: 1166 QGSVHFAAIRTSDAGRYRCEASNSAGVD-----AWEVELRVLEPPHWGADETSGLLERVA 1220

Query: 363  -GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISV--- 418
               A L C    +P P     +W +G               P+ E   G  PG+  +   
Sbjct: 1221 GENASLPCPARGTPKPQV---TWRKG---------------PSSEPLHG-QPGVAVLEEG 1261

Query: 419  -LHISGTQESDFSRSFNCSARNRLGEGGAQASL 450
             L ++    +D S  + C A N +G    +A L
Sbjct: 1262 SLFLASVSPAD-SGDYECQATNEVGSTSRRAKL 1293



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 134/549 (24%), Positives = 191/549 (34%), Gaps = 88/549 (16%)

Query: 22   WSRYWISGNAANGQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLG 80
            WS+  +       Q  +H   +   D   Y C+A+  AG+ +   +L VL PP       
Sbjct: 1153 WSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADET 1212

Query: 81   GPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLT 140
               +  VAG  A+L C +RG   P P++ W +      G +      + G     E +L 
Sbjct: 1213 SGLLERVAGENASLPCPARG--TPKPQVTWRK------GPSSEPLHGQPGVAVLEEGSLF 1264

Query: 141  LTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTV--QEGEKVIFLC 198
            L   S  D   + C+A ++   T R   + + +  PP +        V    G+ +   C
Sbjct: 1265 LASVSPADSGDYECQATNEVGSTSRRAKLVVYV--PPSIREDGRKANVSGMAGQSLTLEC 1322

Query: 199  QATAQP---------------PV--TGYRWAKGGSPVLGAR----GPRLEVVADASFLTE 237
             A   P               P+   GY W  G   V G R    G  L         + 
Sbjct: 1323 DANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSG 1382

Query: 238  PVSCEVSNAVGSANRSTALDVLFGPIL--QAKPEPVSVDVGEDASFSCAWRGNPLPRVTW 295
              SC   N  G+A R   L VL  P +      + V    G D    C   G P P+V W
Sbjct: 1383 LYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 1442

Query: 296  TR------RGG--AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA 347
            T+       GG   QV   G  LR+      D G Y C A    S     A + +L V+A
Sbjct: 1443 TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA---FSPAGQQARDFQLRVHA 1499

Query: 348  PPVVTALH---SAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPA 404
            PP +   +             +L C     P P+ + W  D         G  L  +   
Sbjct: 1500 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN-ITWFKD---------GALLPTSTKV 1549

Query: 405  PESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL--PTVR-- 460
              +RGG        L +   Q SD +  + C A N +   GA     R D+   PT+   
Sbjct: 1550 VYTRGG------RQLQLGRAQSSD-AGVYTCKASNAV---GAAEKATRLDVYVPPTIEGA 1599

Query: 461  -----IVAGVAAATTTLLMVITG--VALCCWRHSKASASFSEQKNLMRIPGSSDGSSSR- 512
                 +V  VA     L  V  G       W H     + S +  L      +DGS  R 
Sbjct: 1600 GGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRL-----ETDGSVLRL 1654

Query: 513  -GPEEEETG 520
              P E  +G
Sbjct: 1655 ESPGEASSG 1663



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 91/333 (27%), Positives = 133/333 (39%), Gaps = 45/333 (13%)

Query: 37   DLHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLT 95
            +L ++ +E +D  +Y C A  A G   R   L +LV P    + G  S+ L  G    L 
Sbjct: 4092 ELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLR 4149

Query: 96   CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG-TPGSVESTLTLTPFSHDDGATFVC 154
            C +RG   PTP + W          T +   + EG +     STL     S +D  T+VC
Sbjct: 4150 CAARGS--PTPRIGW----------TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVC 4197

Query: 155  RARSQALPTGRDTAIT-LSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 213
             A ++    GR  A++ + ++  P +   A  + V+     I L       PV    W K
Sbjct: 4198 WAENRV---GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIK 4254

Query: 214  GGSPVLGARGPRLEVVADASFLT---------EPVSCEVSNAVGSANRSTALDVLFGPIL 264
             G P+   RG  L        LT             C   N +G A +   L +   P+ 
Sbjct: 4255 DGLPL---RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 4311

Query: 265  QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLR--------LPSVG 316
            Q +P+ ++V  G+D +  C   G P P + W + G  Q L +   LR        L +V 
Sbjct: 4312 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG--QPLRASRRLRTLPDGSLWLENVE 4369

Query: 317  PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP 349
              DAG Y C A    + L    A A L V   P
Sbjct: 4370 TGDAGTYDCVAH---NLLGSATARAFLVVRGEP 4399



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 100/372 (26%), Positives = 144/372 (38%), Gaps = 54/372 (14%)

Query: 38   LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L ++ +   D   Y C A  A G  S   ++ +   P      G P+V++     A L C
Sbjct: 3637 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS--GPPAVNVSVNQTALLPC 3694

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
            ++  D  P P + W +D V LD  +    +L EG+       L + P    D   ++C A
Sbjct: 3695 QA--DGVPAPLVSWRKDRVPLDPRSPRFEILPEGS-------LRIQPVLAQDAGHYLCLA 3745

Query: 157  RSQALPT--GRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG 214
             + A     GRD    L +  PP +  S S  T+      +  C+A+  P      W  G
Sbjct: 3746 SNSAGSDRQGRD----LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG 3801

Query: 215  GSPVLGAR-GPRLEVVADASFLTEP-------VSCEVSNAVGSANRSTALDVLFGPILQA 266
                   + G    + ++A  LT P         C VSN VG A+R   + V   P +  
Sbjct: 3802 QKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD 3861

Query: 267  KPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRLPSVGPE 318
                 +V +      +C   G P P V+W++ G        G +V  SGA L +    P 
Sbjct: 3862 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGA-LEIGQALPI 3920

Query: 319  DAGDYVCRAEAGLSGLRGGAAEAR----LTVNAPPVVTALHSAPAFLRGPAR----LQCL 370
             AG Y C A       R  A  A     LTV A PVV  L   P+ +R  A     L C 
Sbjct: 3921 HAGRYTCSA-------RNSAGVAHKHVFLTVQASPVVKPL---PSVVRAVAEEEVLLPCE 3970

Query: 371  VFASPAPDAVVW 382
                P P  + W
Sbjct: 3971 ASGIPRP-TITW 3981



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 107/456 (23%), Positives = 168/456 (36%), Gaps = 84/456 (18%)

Query: 38   LHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L +   + +D   Y C A+ +AG   R   + VLVPP          + ++ G  A+L C
Sbjct: 2408 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMC 2467

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
               G   P P+L WF+DG  L     H       +P  V   L +   +      + C A
Sbjct: 2468 NVTG--HPQPKLTWFKDGRPLARGDAHHI-----SPDGV--LLQVLQANLSSAGHYSCIA 2518

Query: 157  RSQALPTGRDTA-ITLSLQYPPEVTLSASPH-----TVQEGEKVIFLCQATAQPPVTGYR 210
               A   G  T    LS+   P +   A        TV     +  +C+A A P      
Sbjct: 2519 ---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPS-PNIT 2574

Query: 211  WAKGGSPVLGARGPRL-------EVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPI 263
            W K G+P   +R  +L       +++          +C V+N +G A ++  ++VL  P 
Sbjct: 2575 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 2634

Query: 264  LQAKPEP--------VSVDVGEDASFSCAWRGNPLPRVTWTRRGGA-------QVLGSGA 308
            + +K +P        V   V    +  C     P P + W + G         QVLG G 
Sbjct: 2635 I-SKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 2693

Query: 309  TLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFL------- 361
             L++      D+G Y+C A   ++G      +  + +  PP+   +    A         
Sbjct: 2694 LLQIQPTQVSDSGRYLCVA-TNVAG--EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 2750

Query: 362  --------------RGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPES 407
                            PA L C   A P PD + W  ++  L AG +   L         
Sbjct: 2751 EARGGVTEYREIVENNPAYLYCDTNAIPPPD-LTWYREDQPLSAGDEVSVL--------- 2800

Query: 408  RGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 443
            +GG       VL I   +  +  R ++C A N +GE
Sbjct: 2801 QGG------RVLQIPLVRAENAGR-YSCKASNEVGE 2829



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 120/458 (26%), Positives = 164/458 (35%), Gaps = 93/458 (20%)

Query: 38   LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQV----------------LG 80
            L I+P ++ D   Y C AT  AG   +   + + VPP   +V                 G
Sbjct: 2695 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARG 2754

Query: 81   GPSV--SLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST 138
            G +    +V   PA L C +  +A P P+L W+R+   L  A    ++L+ G        
Sbjct: 2755 GVTEYREIVENNPAYLYCDT--NAIPPPDLTWYREDQPL-SAGDEVSVLQGG------RV 2805

Query: 139  LTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE-----GEK 193
            L +     ++   + C+A ++    G D      L   P V L  +   V+E        
Sbjct: 2806 LQIPLVRAENAGRYSCKASNE---VGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 2862

Query: 194  VIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS---------CEVS 244
            V   C A    PV    W + G P   +  PRL+V+ D   L    +         C   
Sbjct: 2863 VSLQCPALGN-PVPTISWLQNGLPF--SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 2919

Query: 245  NAVGSANRSTALDVLFGP-ILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQV 303
            N  GSA +   L V   P I     E V+  +    S  C    +P P VTW +   A  
Sbjct: 2920 NQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALS 2979

Query: 304  LGSGA-------TLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS 356
            LG          TL+L      D+G Y C A   L+         +L+V  PP   A   
Sbjct: 2980 LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA---LNAAGRDQKLVQLSVLVPP---AFRQ 3033

Query: 357  APAFLRGP-----------ARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAP 405
            AP   RGP           A L C   A P P  V W  D         G+ LV      
Sbjct: 3034 AP---RGPQDAVLVRVGDKAVLSCETDALPEP-TVTWYKD---------GQPLVLAQRTQ 3080

Query: 406  ESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 443
              RGG        L I   Q SD    ++C   N  GE
Sbjct: 3081 ALRGG------QRLEIQEAQVSD-KGLYSCKVSNVAGE 3111


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  111 bits (277), Expect = 2e-24
 Identities = 128/461 (27%), Positives = 175/461 (37%), Gaps = 62/461 (13%)

Query: 21  GWSRY-WISGNAANGQH-------DLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLV 71
           GW+ Y W  G    G H        LH   ++  D   Y C+A  QAG   R   L VL 
Sbjct: 64  GWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLT 123

Query: 72  PPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGT 131
           PP          V  +AG    L C + G   PTP++ W +D   +     H  + ++G 
Sbjct: 124 PPSVLGAGAAQEVLGLAGADVELQCWTSGV--PTPQVEWTKDRQPVLPGGPHLQVQEDG- 180

Query: 132 PGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLS--ASPHTVQ 189
                  L +T     D   + C A S A    RD    L +  PP +  S       V 
Sbjct: 181 -----QVLRITGSHVGDEGRYQCVAFSPAGQQARD--FQLRVHAPPTIWGSNETGEVAVM 233

Query: 190 EGEKVIFLCQATAQPPVTGYRWAKGGS------PVLGARGPR-LEVVADASFLTEPVSCE 242
           E   V  LC+A   P      W K G+       V+  RG R L++    S      +C+
Sbjct: 234 EDHLVQLLCEARGVP-TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCK 292

Query: 243 VSNAVGSANRSTALDVLFGPILQ---AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG 299
            SNAVG+A ++T LDV   P ++    +P  V    G   +  C  RG+P P ++W   G
Sbjct: 293 ASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG 352

Query: 300 -------GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP--- 349
                   +++   G+ LRL S G   +G Y C A    S       +  + V  PP   
Sbjct: 353 LPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS---SPAGEAVLQYSVEVQVPPQLL 409

Query: 350 VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRG 409
           V   L      +  P  L C    SP P  + W      L+ G          PA E  G
Sbjct: 410 VAEGLGQVTTIVGQPLELPCQASGSPVP-TIQW------LQNGR---------PAEELAG 453

Query: 410 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 450
                  + LHI    E D S  F C A N  G  GA+  +
Sbjct: 454 VQVASQGTTLHIDHV-ELDHSGLFACQATNEAGTAGAEVEV 493



 Score =  102 bits (253), Expect = 1e-21
 Identities = 115/412 (27%), Positives = 163/412 (39%), Gaps = 61/412 (14%)

Query: 51   YECQA-TQAGLRSRPAQLHVLVPPEA-PQVLGGPSV-SLVAGVPANLTCRSRGDARPTPE 107
            Y C A   AG+    A  HV +  +A P V   PSV   VA     L C + G  RPT  
Sbjct: 2643 YTCSARNSAGV----AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPT-- 2696

Query: 108  LLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDT 167
            + W ++G+ +      Q L     PG     L +   S +D   ++C A++ A      T
Sbjct: 2697 ITWQKEGLNVATGVSTQVL-----PGG---QLRIAHASPEDAGNYLCIAKNSAGSAMGKT 2748

Query: 168  AITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLE 227
             + +  Q PP +       +  EG      C+A   P      W K G PV GA G +  
Sbjct: 2749 RLVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPE-PNITWDKDGQPVSGAEG-KFT 2804

Query: 228  VVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDA 279
            +      L + +        +C   NAVG A R   L +L  P+    P   S+ +G+  
Sbjct: 2805 IQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRL 2864

Query: 280  SFSCAWRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGL 334
               CA RG+P PR+ WT        G      G+TL+  +V  ED+G YVC AE      
Sbjct: 2865 WLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN----- 2919

Query: 335  RGGAAEARLTVNAPPVVTALHSAPAFL----RGPARLQCLVFASPAPDAVVWSWDEGFLE 390
            R G  +A   V+          A ++L     G  +L C+V   P PD + W  D G   
Sbjct: 2920 RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD-IHWIKD-GLPL 2977

Query: 391  AGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLG 442
             GS  R  ++                  L I  T+  D  R + C A N +G
Sbjct: 2978 RGSHLRHQLQN---------------GSLTIRRTERDDAGR-YQCLAENEMG 3013



 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 106/393 (26%), Positives = 149/393 (37%), Gaps = 59/393 (15%)

Query: 26   WISGNAANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEA--PQVLGGP 82
            W+    +     L I   +L D  SY C A+  AG       L V VPP    P  L GP
Sbjct: 647  WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGP 706

Query: 83   SVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVE----ST 138
               ++   P  LTC + G   P+P L+W +DG  +  A         GTPG         
Sbjct: 707  ---VLVNTPVRLTCNATG--APSPTLMWLKDGNPVSPA---------GTPGLQVFPGGRV 752

Query: 139  LTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLC 198
            LTL      D   + C A S      +D  + L +  PP +       +V   E V   C
Sbjct: 753  LTLASARASDSGRYSCVAVSAVGEDRQD--VVLQVHMPPSILGEELNVSVVANESVALEC 810

Query: 199  QATAQPPVTGYRWAKGGSPVLGARGPRLEV-----------VADASFLTEPVSCEVSNAV 247
            Q+ A PP     W K G P+    G  L             V DA   T    CE  N  
Sbjct: 811  QSHAMPPPV-LSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYT----CEALNQA 865

Query: 248  GSANRSTALDVLFGPILQAKPE-PVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS 306
            G + +   L+V   P+   +    ++V  G     SC  RG P P+++W R+ G  + G 
Sbjct: 866  GHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISW-RKDGQPLPGE 924

Query: 307  GATLR-LPSVGP---------EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS 356
            GA L+ + +VG             G Y C      + +   + + +L V+ PP +     
Sbjct: 925  GAGLQHVSAVGRLLYLGQAQLAQEGTYTCECS---NVVGNSSQDLQLEVHVPPQIAGPRE 981

Query: 357  APAFLR----GPARLQCLVFASPAPDAVVWSWD 385
             P  +     G A L+C     P P  V W  D
Sbjct: 982  PPTQVSVVQDGVATLECNATGKP-PPTVTWERD 1013



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 126/433 (29%), Positives = 170/433 (39%), Gaps = 62/433 (14%)

Query: 38   LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L +   E+ D ASY C A  QAG   +   L V VPP     L    V+ +     +L C
Sbjct: 1619 LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAG-LDLEQVTAILNSSVSLPC 1677

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
                 A P PE+ W++D   L  +   +  L  GT      TL L      D   + C A
Sbjct: 1678 DVH--AHPNPEVTWYKDSQAL--SLGEEVFLLPGT-----HTLQLGRARLSDSGMYTCEA 1728

Query: 157  RSQALPTGRD-TAITLSLQYPPEVTLSASPHTVQE------GEKVIFLCQATAQPPVTGY 209
             + A   GRD   + LS+  PP      +P   Q+      G+K +  C+  A P  T  
Sbjct: 1729 LNAA---GRDQKLVQLSVLVPP--AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-V 1782

Query: 210  RWAKGGSPVLGAR-------GPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGP 262
             W K G P++ A+       G RLE+           SC+VSN  G A R+  L V   P
Sbjct: 1783 TWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPP 1842

Query: 263  ILQ-AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTR-------RGGAQVLGSGATLRLPS 314
              +  K E VS   G     +C   G P P VTW +            V+  G  L+L  
Sbjct: 1843 TFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSR 1902

Query: 315  VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPV-VTALHSAPAFLRG-PARLQCLVF 372
            + P  AG Y C AE   +  R     A L   AP +  + +      L G   RL C   
Sbjct: 1903 LQPAQAGTYTCVAENTQAEARKDFVVAVLV--APRIRSSGVAREHHVLEGQEVRLDCEAD 1960

Query: 373  ASPAPDAVVWSWDEGFL--EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 430
              P PD V W  D   L  + G   RF ++        GG        L + G + SD +
Sbjct: 1961 GQPPPD-VAWLKDGSPLGQDMGPHLRFYLD--------GG-------SLVLKGLRASD-A 2003

Query: 431  RSFNCSARNRLGE 443
             ++ C A N  GE
Sbjct: 2004 GAYTCVAHNPAGE 2016



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 132/499 (26%), Positives = 203/499 (40%), Gaps = 84/499 (16%)

Query: 30  NAANGQHDLHIRPVELEDEAS---YECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS 85
           N +  + D  +  +E   EAS   Y C A+  AG       + V VPP+     G   V+
Sbjct: 359 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVT 418

Query: 86  LVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFS 145
            + G P  L C++ G   P P + W ++G   +     Q +  +GT      TL +    
Sbjct: 419 TIVGQPLELPCQASGS--PVPTIQWLQNGRPAEELAGVQ-VASQGT------TLHIDHVE 469

Query: 146 HDDGATFVCRARSQALPTGRDTAITLSLQYPP---EVTLSASPHTVQEGEKVIFLCQ--- 199
            D    F C+A ++A   G +  +++  ++ P   EV +       +        C    
Sbjct: 470 LDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPV 529

Query: 200 -----ATAQPPVT------GYRWAKG-GSPVLGARGPRLEV----VADASFLTEPVSCEV 243
                A  +PP+       G  W +  G PV  +  P L++    + D    T    C  
Sbjct: 530 HRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYT----CAA 585

Query: 244 SNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDAS--FSCAWRGNPLPRVTWTRRG-- 299
           +N  G + R  AL VL  P ++  P PV+  V E+AS    C   G P P V+W +    
Sbjct: 586 TNLAGESKREVALKVLVPPNIE--PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQP 643

Query: 300 -----GAQVLGSGATLRLPSVGPEDAGDYVCRAE--AGLSGLRGGAAEARLTVNAPPVVT 352
                G  V   G  LR+      DAG Y C A   AG + LR G     L VN PP +T
Sbjct: 644 VSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-----LRVNVPPRIT 698

Query: 353 ALHS--APAFLRGPARLQCLVFASPAPDAVVWSWDEGFLE-AGSQGRFLVETFPAPESRG 409
              S   P  +  P RL C    +P+P  ++W  D   +  AG+ G   ++ FP     G
Sbjct: 699 LPPSLPGPVLVNTPVRLTCNATGAPSP-TLMWLKDGNPVSPAGTPG---LQVFP-----G 749

Query: 410 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAAT 469
           G       VL ++  + SD  R ++C A + +GE        R+D++  V +   +    
Sbjct: 750 G------RVLTLASARASDSGR-YSCVAVSAVGE-------DRQDVVLQVHMPPSILGEE 795

Query: 470 TTLLMVIT-GVALCCWRHS 487
             + +V    VAL C  H+
Sbjct: 796 LNVSVVANESVALECQSHA 814



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 115/445 (25%), Positives = 171/445 (38%), Gaps = 83/445 (18%)

Query: 38   LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPANLT 95
            L++   +L  E +Y C+ +   G  S+  QL V VPP+       P+ VS+V    A L 
Sbjct: 938  LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 997

Query: 96   CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 155
            C + G  +P P + W RDG  + GA     L  +G    VE                   
Sbjct: 998  CNATG--KPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVE------------------- 1035

Query: 156  ARSQALPTGRDTAIT------------LSLQYPPEVTLSASPHT---VQEGEKVIFLCQA 200
             R+QA  TGR + +             LS+  PPE+     P T         +  LC+A
Sbjct: 1036 -RAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEA 1094

Query: 201  TAQPPVTGYRWAKGGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRS 253
               PP    RW +G  PV       L A G  L++       +   SC  SN  G A R+
Sbjct: 1095 MGIPP-PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN 1153

Query: 254  TALDVLFGPILQAKP--EPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLG------ 305
             +++VL  P ++ +   E + V  G+ A   C   G+P P++TW + G     G      
Sbjct: 1154 FSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHIS 1213

Query: 306  -SGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV------TALHSAP 358
              G  L++       AG Y C A    + +       +L+V   P +      +A     
Sbjct: 1214 PDGVLLQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVT 1270

Query: 359  AFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISV 418
              +  P  L C   A P+P+ + W  D    EA    + L      P + G         
Sbjct: 1271 VTVNNPISLICEALAFPSPN-ITWMKDGAPFEASRNIQLL------PGTHG--------- 1314

Query: 419  LHISGTQESDFSRSFNCSARNRLGE 443
            L I   Q+ D +  + C   N LGE
Sbjct: 1315 LQILNAQKED-AGQYTCVVTNELGE 1338



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 110/426 (25%), Positives = 162/426 (38%), Gaps = 59/426 (13%)

Query: 38   LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L +  V   D  +Y C A ++AG   R  QL V+ PP          +SL  G P  L C
Sbjct: 2176 LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLC 2235

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
             ++G   P P + W +DG         Q L +          L +      D   + C A
Sbjct: 2236 DAQGT--PQPNITWHKDG---------QALTRLENNSRATRVLRVR-----DAGLYTCLA 2279

Query: 157  RSQALPTGR-DTAITLSLQYPPEVTLSASPHTVQ--EGEKVIFLCQATAQPPVTGYRWAK 213
             S   P G  + +  + +Q PP +     P  V      +++  C   A+P      W +
Sbjct: 2280 ES---PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEP-APKITWHR 2335

Query: 214  GGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQA 266
             G  +          RG  L++ A ++  +   SC   NA GS + +  +++   P +++
Sbjct: 2336 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 2395

Query: 267  KPEPVSVDVGEDASFSCAWRGNPLPRVTW--------TRRGGAQVLGSGATLRLPSVGPE 318
             P  V+V V + A   C   G P P V+W         R    ++L  G +LR+  V  +
Sbjct: 2396 GPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG-SLRIQPVLAQ 2454

Query: 319  DAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS-APAFLRGPARLQCLVFASPAP 377
            DAG Y+C A       R G     L V  PP +    S        PA L C    SP P
Sbjct: 2455 DAGHYLCLASNSAGSDRQG---RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKP 2511

Query: 378  DAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSA 437
              VVW W +G              F   +    L P    +L   G Q+   S  F C  
Sbjct: 2512 -LVVW-WKDG----------QKLDFRLQQGAYRLLPSNALLLTAPGPQD---SAQFECVV 2556

Query: 438  RNRLGE 443
             N +GE
Sbjct: 2557 SNEVGE 2562



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 104/370 (28%), Positives = 138/370 (37%), Gaps = 42/370 (11%)

Query: 38  LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
           L I  V+L DE  Y C AT  AG   R   L VLVPP      G  + +++      L C
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP--GPVNKAVLENASVTLEC 625

Query: 97  RSRGDARPTPELLWFRDGVLLDGATFHQTLLK-EGTPGSVES-TLTLTPFSHDDGATFVC 154
            + G   P P++ WF+          HQ +    G   SV+   L +      D  ++ C
Sbjct: 626 LASGV--PPPDVSWFKG---------HQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 674

Query: 155 RARSQALPTGRDTAITLSLQYPPEVTLSAS-PHTVQEGEKVIFLCQATAQPPVTGYRWAK 213
            A + A  T  +    L +  PP +TL  S P  V     V   C AT  P  T   W K
Sbjct: 675 VASNVAGST--ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLK 731

Query: 214 GGSPVLGARGPRLEVVADASFLTEP---------VSCEVSNAVGSANRSTALDVLFGPIL 264
            G+PV  A  P L+V      LT            SC   +AVG   +   L V   P +
Sbjct: 732 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 791

Query: 265 QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGP 317
             +   VSV   E  +  C     P P ++W + G       G  +    A L++     
Sbjct: 792 LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADV 851

Query: 318 EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR--GPARLQCLVFASP 375
            DAG Y C A   L+          L V   PV     S    +R   P RL C     P
Sbjct: 852 WDAGHYTCEA---LNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVP 908

Query: 376 APDAVVWSWD 385
            P  + W  D
Sbjct: 909 FP-KISWRKD 917



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 130/481 (27%), Positives = 183/481 (38%), Gaps = 76/481 (15%)

Query: 34   GQHDLHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVP 91
            G   L +      D   Y C A  A G   +   L V +PP    +LG   +VS+VA   
Sbjct: 749  GGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS---ILGEELNVSVVANES 805

Query: 92   ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHD-DGA 150
              L C+S   A P P L W++DG  L+         + G   S +  L     +   D  
Sbjct: 806  VALECQSH--AMPPPVLSWWKDGRPLEP--------RPGVHLSADKALLQVDRADVWDAG 855

Query: 151  TFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPH-TVQEGEKVIFLCQATAQPPVTGY 209
             + C A +QA  + +     L++   P   L  S   TV+EG      C+    P     
Sbjct: 856  HYTCEALNQAGHSEKH--YNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVP-FPKI 912

Query: 210  RWAKGGSPVLGARGP--------RLEVVADASFLTEPV-SCEVSNAVGSANRSTALDVLF 260
             W K G P+ G            RL  +  A    E   +CE SN VG++++   L+V  
Sbjct: 913  SWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHV 972

Query: 261  GPILQAKPEP-VSVDVGED--ASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATL 310
             P +    EP   V V +D  A+  C   G P P VTW R G       G Q+   G +L
Sbjct: 973  PPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSL 1032

Query: 311  RLPSVGPEDAGDYVCRAEAGLSGLRGGA-AEARLTVNAPPVVTA----LHSAPAFLRGPA 365
             +        G Y C AE     L G A  +  L+V  PP +      L +  A L  P 
Sbjct: 1033 HVERAQAAHTGRYSCVAE----NLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPL 1088

Query: 366  RLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQ 425
             L C     P P A+ W   E  +  G     L          GG       +L ++ TQ
Sbjct: 1089 TLLCEAMGIP-PPAIRWFRGEEPVSPGEDTYLLA---------GGW------MLKMTQTQ 1132

Query: 426  ESDFSRSFNCSARNRLGEGG--------AQASLGRRDLLPTVRIVAGVAAATTTLLMVIT 477
            E D S  ++C A N  GE             S+   DL   ++++ G    T  L+  +T
Sbjct: 1133 EQD-SGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDG---QTAHLMCNVT 1188

Query: 478  G 478
            G
Sbjct: 1189 G 1189



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 106/409 (25%), Positives = 153/409 (37%), Gaps = 66/409 (16%)

Query: 34   GQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQ--VLGGPSVSLV-AG 89
            G H L I   + ED   Y C  T + G   +   + VL+PP   +   L    V  V   
Sbjct: 1311 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTK 1370

Query: 90   VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDG 149
            V + LT      A P P + W++DG  +  ++  Q +L EG        L + P    D 
Sbjct: 1371 VNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQ-VLGEG------RLLQIQPTQVSDS 1423

Query: 150  ATFVCRARSQALPTGRDTAITLSLQYPPEV-----------TLSASPHT---------VQ 189
              ++C A + A    +D    + +Q PP              LS              + 
Sbjct: 1424 GRYLCVATNVAGEDDQD--FNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 1481

Query: 190  EGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPV---------S 240
            E       C   A PP     W +   P+  + G  + V+     L  P+         S
Sbjct: 1482 ENNPAYLYCDTNAIPP-PDLTWYREDQPL--SAGDEVSVLQGGRVLQIPLVRAENAGRYS 1538

Query: 241  CEVSNAVGSANRSTALDVLFGPIL----QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWT 296
            C+ SN VG       L VL  P++    +   E V+V+     S  C   GNP+P ++W 
Sbjct: 1539 CKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL 1598

Query: 297  RRG-------GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLT--VNA 347
            + G         QVL  G  L++ +    DA  Y+C AE      + G+AE   T  V  
Sbjct: 1599 QNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAEN-----QAGSAEKLFTLRVQV 1653

Query: 348  PPVVTA--LHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQ 394
            PP +    L    A L     L C V A P P+ V W  D   L  G +
Sbjct: 1654 PPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPE-VTWYKDSQALSLGEE 1701



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 115/441 (26%), Positives = 157/441 (35%), Gaps = 75/441 (17%)

Query: 70  LVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLD----------- 118
           +VPP   +     +VS +AG    L C + G   P PE++W +D  L+            
Sbjct: 14  VVPPSIREDGRKANVSGMAGQSLTLECDANGF--PVPEIVWLKDAQLVGVPLGWAGYGWD 71

Query: 119 ---GATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQY 175
              G      LL EG       +L        D   + CRA +QA    RD    L +  
Sbjct: 72  LGWGQVGGHRLLDEG------QSLHFPRIQEGDSGLYSCRAENQAGTAQRD--FHLLVLT 123

Query: 176 PPEVTLSASPHTV--QEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADAS 233
           PP V  + +   V    G  V   C  T+  P     W K   PVL   GP L+V  D  
Sbjct: 124 PPSVLGAGAAQEVLGLAGADVELQCW-TSGVPTPQVEWTKDRQPVLPG-GPHLQVQEDGQ 181

Query: 234 FLTEPVS---------CEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGED--ASFS 282
            L    S         C   +  G   R   L V   P +    E   V V ED      
Sbjct: 182 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLL 241

Query: 283 CAWRGNPLPRVTWTRRGGAQVLGS-------GATLRLPSVGPEDAGDYVCRAEAGLSGLR 335
           C  RG P P +TW + G      +       G  L+L      DAG Y C+A   +    
Sbjct: 242 CEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAV---- 297

Query: 336 GGAAE--ARLTVNAPPVVTALHSAPAFLRG----PARLQCLVFASPAPDAVVWSWDEGFL 389
            GAAE   RL V  PP +      P  ++     P  L+C+    P+P     SW    L
Sbjct: 298 -GAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP---TLSWHHEGL 353

Query: 390 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQAS 449
                    +ET               SVL +    E+  S  ++C A +  GE   Q S
Sbjct: 354 PVAESNESRLETDG-------------SVLRLESPGEAS-SGLYSCVASSPAGEAVLQYS 399

Query: 450 LGRRDLLPTVRIVAGVAAATT 470
           +    + P + +  G+   TT
Sbjct: 400 V-EVQVPPQLLVAEGLGQVTT 419



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 114/436 (26%), Positives = 163/436 (37%), Gaps = 60/436 (13%)

Query: 34   GQHDLHIRPVELEDEASYECQATQAGLRSRP-AQLHVLVPPEAPQVLGGP--SVSLVAGV 90
            G H L +    L D   Y C+A  A  R +   QL VLVPP   Q   GP  +V +  G 
Sbjct: 1707 GTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGD 1766

Query: 91   PANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGA 150
             A L+C +  DA P P + W++DG  L  A   Q  L+ G        L +      D  
Sbjct: 1767 KAVLSCET--DALPEPTVTWYKDGQPLVLAQRTQA-LRGG------QRLEIQEAQVSDKG 1817

Query: 151  TFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQATAQPPVTG 208
             + C+  + A    R    TL++Q PP    +    TV +  G  ++  C  +  P  T 
Sbjct: 1818 LYSCKVSNVAGEAVR--TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPT- 1873

Query: 209  YRWAKGGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFG 261
              W K   PV       + +RG RL++           +C   N    A +   + VL  
Sbjct: 1874 VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA 1933

Query: 262  PILQAK--PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG--AQVLG-------SGATL 310
            P +++        V  G++    C   G P P V W + G    Q +G        G +L
Sbjct: 1934 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 1993

Query: 311  RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARL-TVNA---PPVVTALHSAPAFLRGPAR 366
             L  +   DAG Y C A            +ARL TVN    P +      +   +  P  
Sbjct: 1994 VLKGLRASDAGAYTCVAH------NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGE 2047

Query: 367  LQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQE 426
            L  +V        +  SW             L +  P P S+  L  G    L IS  Q 
Sbjct: 2048 LVTMVCPVRGSPPIHVSW-------------LKDGLPLPLSQRTLLHGSGHTLRISKVQL 2094

Query: 427  SDFSRSFNCSARNRLG 442
            +D +  F C A +  G
Sbjct: 2095 AD-AGIFTCVAASPAG 2109



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 102/372 (27%), Positives = 140/372 (37%), Gaps = 51/372 (13%)

Query: 36   HDLHIRPVELEDEASYEC-QATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANL 94
            H L I  V+L D   + C  A+ AG+  R   L V VPP    V     V +V G    L
Sbjct: 2085 HTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVEL 2144

Query: 95   TCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 154
             C +RG   P P + W +DG  L   +  Q             +L L      D  T+ C
Sbjct: 2145 PCEARG--VPLPLVSWMKDGEPLLSQSLEQ-----------GPSLQLEAVGAGDSGTYSC 2191

Query: 155  RARSQALPTGRDTAITLSLQYPPEVTLSASPH--TVQEGEKVIFLC--QATAQPPVTGYR 210
             A S+A    R     L++  PP +  S  P   ++  G  +  LC  Q T QP +T   
Sbjct: 2192 VAVSEAGEARRH--FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--- 2246

Query: 211  WAKGGSPVL----GARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQA 266
            W K G  +      +R  R+  V DA   T    C   +  G+  +S  + V   P +  
Sbjct: 2247 WHKDGQALTRLENNSRATRVLRVRDAGLYT----CLAESPAGAIEKSFRVRVQAPPNIVG 2302

Query: 267  KPEP---VSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVG 316
               P   V +  G+     C+    P P++TW R G         Q    G  L+L ++ 
Sbjct: 2303 PRGPRFVVGLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALS 2361

Query: 317  PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAF---LRGPARLQCLVFA 373
              D+GDY C A         G+      V    V T     PA    +   A L C    
Sbjct: 2362 TADSGDYSCTARNA-----AGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADG 2416

Query: 374  SPAPDAVVWSWD 385
             PAP  V W  D
Sbjct: 2417 VPAP-LVSWRKD 2427



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 91/333 (27%), Positives = 133/333 (39%), Gaps = 45/333 (13%)

Query: 37   DLHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLT 95
            +L ++ +E +D  +Y C A  A G   R   L +LV P    + G  S+ L  G    L 
Sbjct: 2810 ELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLR 2867

Query: 96   CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG-TPGSVESTLTLTPFSHDDGATFVC 154
            C +RG   PTP + W          T +   + EG +     STL     S +D  T+VC
Sbjct: 2868 CAARGS--PTPRIGW----------TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVC 2915

Query: 155  RARSQALPTGRDTAIT-LSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 213
             A ++    GR  A++ + ++  P +   A  + V+     I L       PV    W K
Sbjct: 2916 WAENRV---GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIK 2972

Query: 214  GGSPVLGARGPRLEVVADASFLT---------EPVSCEVSNAVGSANRSTALDVLFGPIL 264
             G P+   RG  L        LT             C   N +G A +   L +   P+ 
Sbjct: 2973 DGLPL---RGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 3029

Query: 265  QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLR--------LPSVG 316
            Q +P+ ++V  G+D +  C   G P P + W + G  Q L +   LR        L +V 
Sbjct: 3030 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG--QPLRASRRLRTLPDGSLWLENVE 3087

Query: 317  PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP 349
              DAG Y C A    + L    A A L V   P
Sbjct: 3088 TGDAGTYDCVAH---NLLGSATARAFLVVRGEP 3117



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 100/372 (26%), Positives = 144/372 (38%), Gaps = 54/372 (14%)

Query: 38   LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L ++ +   D   Y C A  A G  S   ++ +   P      G P+V++     A L C
Sbjct: 2355 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS--GPPAVNVSVNQTALLPC 2412

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
            ++  D  P P + W +D V LD  +    +L EG+       L + P    D   ++C A
Sbjct: 2413 QA--DGVPAPLVSWRKDRVPLDPRSPRFEILPEGS-------LRIQPVLAQDAGHYLCLA 2463

Query: 157  RSQALPT--GRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG 214
             + A     GRD    L +  PP +  S S  T+      +  C+A+  P      W  G
Sbjct: 2464 SNSAGSDRQGRD----LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG 2519

Query: 215  GSPVLGAR-GPRLEVVADASFLTEP-------VSCEVSNAVGSANRSTALDVLFGPILQA 266
                   + G    + ++A  LT P         C VSN VG A+R   + V   P +  
Sbjct: 2520 QKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD 2579

Query: 267  KPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRLPSVGPE 318
                 +V +      +C   G P P V+W++ G        G +V  SGA L +    P 
Sbjct: 2580 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGA-LEIGQALPI 2638

Query: 319  DAGDYVCRAEAGLSGLRGGAAEAR----LTVNAPPVVTALHSAPAFLRGPAR----LQCL 370
             AG Y C A       R  A  A     LTV A PVV  L   P+ +R  A     L C 
Sbjct: 2639 HAGRYTCSA-------RNSAGVAHKHVFLTVQASPVVKPL---PSVVRAVAEEEVLLPCE 2688

Query: 371  VFASPAPDAVVW 382
                P P  + W
Sbjct: 2689 ASGIPRP-TITW 2699



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 107/456 (23%), Positives = 168/456 (36%), Gaps = 84/456 (18%)

Query: 38   LHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L +   + +D   Y C A+ +AG   R   + VLVPP          + ++ G  A+L C
Sbjct: 1126 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMC 1185

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
               G   P P+L WF+DG  L     H       +P  V   L +   +      + C A
Sbjct: 1186 NVTG--HPQPKLTWFKDGRPLARGDAHHI-----SPDGV--LLQVLQANLSSAGHYSCIA 1236

Query: 157  RSQALPTGRDTA-ITLSLQYPPEVTLSASPH-----TVQEGEKVIFLCQATAQPPVTGYR 210
               A   G  T    LS+   P +   A        TV     +  +C+A A P      
Sbjct: 1237 ---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPS-PNIT 1292

Query: 211  WAKGGSPVLGARGPRL-------EVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPI 263
            W K G+P   +R  +L       +++          +C V+N +G A ++  ++VL  P 
Sbjct: 1293 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1352

Query: 264  LQAKPEP--------VSVDVGEDASFSCAWRGNPLPRVTWTRRGGA-------QVLGSGA 308
            + +K +P        V   V    +  C     P P + W + G         QVLG G 
Sbjct: 1353 I-SKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 1411

Query: 309  TLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFL------- 361
             L++      D+G Y+C A   ++G      +  + +  PP+   +    A         
Sbjct: 1412 LLQIQPTQVSDSGRYLCVA-TNVAG--EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 1468

Query: 362  --------------RGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPES 407
                            PA L C   A P PD + W  ++  L AG +   L         
Sbjct: 1469 EARGGVTEYREIVENNPAYLYCDTNAIPPPD-LTWYREDQPLSAGDEVSVL--------- 1518

Query: 408  RGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 443
            +GG       VL I   +  +  R ++C A N +GE
Sbjct: 1519 QGG------RVLQIPLVRAENAGR-YSCKASNEVGE 1547



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 120/458 (26%), Positives = 164/458 (35%), Gaps = 93/458 (20%)

Query: 38   LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQV----------------LG 80
            L I+P ++ D   Y C AT  AG   +   + + VPP   +V                 G
Sbjct: 1413 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARG 1472

Query: 81   GPSV--SLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST 138
            G +    +V   PA L C +  +A P P+L W+R+   L  A    ++L+ G        
Sbjct: 1473 GVTEYREIVENNPAYLYCDT--NAIPPPDLTWYREDQPL-SAGDEVSVLQGG------RV 1523

Query: 139  LTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE-----GEK 193
            L +     ++   + C+A ++    G D      L   P V L  +   V+E        
Sbjct: 1524 LQIPLVRAENAGRYSCKASNE---VGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 1580

Query: 194  VIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS---------CEVS 244
            V   C A    PV    W + G P   +  PRL+V+ D   L    +         C   
Sbjct: 1581 VSLQCPALGN-PVPTISWLQNGLPF--SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 1637

Query: 245  NAVGSANRSTALDVLFGP-ILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQV 303
            N  GSA +   L V   P I     E V+  +    S  C    +P P VTW +   A  
Sbjct: 1638 NQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALS 1697

Query: 304  LGSGA-------TLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS 356
            LG          TL+L      D+G Y C A   L+         +L+V  PP   A   
Sbjct: 1698 LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA---LNAAGRDQKLVQLSVLVPP---AFRQ 1751

Query: 357  APAFLRGP-----------ARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAP 405
            AP   RGP           A L C   A P P  V W  D         G+ LV      
Sbjct: 1752 AP---RGPQDAVLVRVGDKAVLSCETDALPEP-TVTWYKD---------GQPLVLAQRTQ 1798

Query: 406  ESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 443
              RGG        L I   Q SD    ++C   N  GE
Sbjct: 1799 ALRGG------QRLEIQEAQVSD-KGLYSCKVSNVAGE 1829


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  110 bits (274), Expect = 5e-24
 Identities = 123/451 (27%), Positives = 182/451 (40%), Gaps = 56/451 (12%)

Query: 38   LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPE-APQVLGGPSVSLVAGVPANLT 95
            LHI+   + D   Y C AT A G   R   L V VPP  AP   G  +++++  V   L 
Sbjct: 3768 LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAP---GPTNMTVIVNVQTTLA 3824

Query: 96   CRSRGDARPTPELLWFRDGVLL--DGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 153
            C + G   P P + W ++G LL  D       LL  G      S + ++P S DD AT+ 
Sbjct: 3825 CEATGI--PKPSINWRKNGHLLNVDQNQNSYRLLSSG------SLVIISP-SVDDTATYE 3875

Query: 154  CRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 213
            C   + A    R   + L++Q PP +    +   V +    +  C A+  P      W K
Sbjct: 3876 CTVTNGAGDDKR--TVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVP-FPSIHWTK 3932

Query: 214  GGSPVLGARGP--------RLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQ 265
             G  +L  RG          +E++A         +C   NA GSA+R   L V   P++Q
Sbjct: 3933 NGIRLL-PRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQ 3991

Query: 266  AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRLPSVGP 317
             +P  + V +       C   G P P +TW + G           VL SG  L++     
Sbjct: 3992 PQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG-LQISRAVR 4050

Query: 318  EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTA-LHSAPAFLRGPARLQCLVFASPA 376
            EDAG Y+C A+       G   + +L V  PPV++  L      +  P  L C     P 
Sbjct: 4051 EDAGTYMCVAQNPAGTALG---KIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPP 4107

Query: 377  PD--------AVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESD 428
            PD        A+V S  +  L +GS    L   F  P   G  G       +++G+  + 
Sbjct: 4108 PDITWHKDGRAIVESIRQRVLSSGS----LQIAFVQP---GDAGHYTCMAANVAGSSSTS 4160

Query: 429  FSRSFNCSARNRLGEGGAQASLGRRDLLPTV 459
               + +   R R  EG    +   + +LP V
Sbjct: 4161 TKLTVHVPPRIRSTEGHYTVNENSQAILPCV 4191



 Score =  100 bits (248), Expect = 5e-21
 Identities = 100/370 (27%), Positives = 157/370 (42%), Gaps = 63/370 (17%)

Query: 24   RYWISGNAANGQH---------DLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPP 73
            R WI  +A   Q+          LHI  V+L+D   Y C A+  AG  ++   + V V P
Sbjct: 922  RRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLP 981

Query: 74   EAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPG 133
                  G   +S + G+P  L C++ G+  P P ++W + G L+       T   + + G
Sbjct: 982  TIQH--GQQILSTIEGIPVTLPCKASGN--PKPSVIWSKKGELIS------TSSAKFSAG 1031

Query: 134  SVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAIT-------------LSLQYPPEVT 180
            +  S   ++P   + G  +VC A + A    R   +T             LS   P E++
Sbjct: 1032 ADGSLYVVSPGGEESGE-YVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEIS 1090

Query: 181  LSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASF-LTEPV 239
            + A       GE+V   C+  + PP     WAK  + ++    PR   +   S  +TE  
Sbjct: 1091 VLA-------GEEVTLPCEVKSLPPPI-ITWAKE-TQLISPFSPRHTFLPSGSMKITETR 1141

Query: 240  S-------CEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPR 292
            +       C  +N  G+  ++  L+V   P +Q  P+ + V VG+     C  +G PLP 
Sbjct: 1142 TSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPV 1201

Query: 293  VTWTRRGGAQVLGSG--------ATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLT 344
            +TW+ +GG+ +L  G         TL +    P DAG Y C A   ++G      E  L 
Sbjct: 1202 ITWS-KGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVA-TNIAGT--DETEITLH 1257

Query: 345  VNAPPVVTAL 354
            V  PP V  L
Sbjct: 1258 VQEPPTVEDL 1267



 Score = 95.9 bits (237), Expect = 9e-20
 Identities = 98/383 (25%), Positives = 149/383 (38%), Gaps = 40/383 (10%)

Query: 22   WSRYWISGNAANGQH------DLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPE 74
            W +  I+ N +   H       L I     ED  +Y C A   AG      +L+V VPP 
Sbjct: 4021 WQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPP- 4079

Query: 75   APQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGS 134
               V+       V  V   +T     D  P P++ W +DG  +   +  Q +L  G+   
Sbjct: 4080 ---VISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIV-ESIRQRVLSSGS--- 4132

Query: 135  VESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKV 194
                L +      D   + C A + A  +   T +T+ +  PP +  +   +TV E  + 
Sbjct: 4133 ----LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHV--PPRIRSTEGHYTVNENSQA 4186

Query: 195  IFLCQATAQPPVTGYRWAKGGSPVLGARG-----PRLEVVADASFLTEP--VSCEVSNAV 247
            I  C A   P      W K    +    G     P  E++ +   L +    +C  +NA 
Sbjct: 4187 ILPCVADGIP-TPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAA 4245

Query: 248  GSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGA-----Q 302
            G    + +L V   P     P  VS++ GE    SC   G PLP++TWT           
Sbjct: 4246 GEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFD 4305

Query: 303  VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAF-- 360
             +   + L +  V  ED+G YVC AE  +  ++   A   + V  PPV    + +     
Sbjct: 4306 SVNGHSELVIERVSKEDSGTYVCTAENSVGFVK---AIGFVYVKEPPVFKGDYPSNWIEP 4362

Query: 361  LRGPARLQCLVFASPAPDAVVWS 383
            L G A L C V   P P  + W+
Sbjct: 4363 LGGNAILNCEVKGDPTP-TIQWN 4384



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 106/402 (26%), Positives = 160/402 (39%), Gaps = 66/402 (16%)

Query: 38   LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPS----VSLVAGVPA 92
            L I   +++D   Y C+AT  AG   +   +++ VPP     +GG      ++++ G   
Sbjct: 2159 LKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPN----IGGSDELTQLTVIEGNLI 2214

Query: 93   NLTCRSRGDARPTPELLWFRDGV-LLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 151
            +L C S G   P P L+W + G  +L  +     +L  G        L ++     D A 
Sbjct: 2215 SLLCESSGI--PPPNLIWKKKGSPVLTDSMGRVRILSGGRQ------LQISIAEKSDAAL 2266

Query: 152  FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT---VQEGEKVIFLCQATAQPPVTG 208
            + C A + A    ++    L +   P +T S S  T   V  G+ +   C+    PP T 
Sbjct: 2267 YSCVASNVAGTAKKE--YNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPT- 2323

Query: 209  YRWAKGGSPVLGARGPRLEVVADASFL---------TEPVSCEVSNAVGSANRSTALDVL 259
              W K G P++ A+G  +E++ +   L         T    C   N  G  ++   L V 
Sbjct: 2324 VTWMKDGHPLIKAKG--VEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVH 2381

Query: 260  FGPIL---QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGAT 309
              P +      PE +SV      S +C   G PLP +TW + G         ++L  G  
Sbjct: 2382 APPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRM 2441

Query: 310  LRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEAR----LTVNAPPVV---TALHSAPAFLR 362
            LRL     EDAG Y C        +R  A E R    L+V  PP +     L       +
Sbjct: 2442 LRLMQTTMEDAGQYTC-------VVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEK 2494

Query: 363  GPARLQCLVFASPAPDAVVWSWDEGFLEAG------SQGRFL 398
                L C V  +P P+ + W  D   L+        S GRFL
Sbjct: 2495 QSVTLTCEVTGNPVPE-ITWHKDGQPLQEDEAHHIISGGRFL 2535



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 109/429 (25%), Positives = 167/429 (38%), Gaps = 71/429 (16%)

Query: 46   EDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPS------VSLVAGVPANLTCRS 98
            E+   Y C AT  AG   R  QL V V P       G S      +S++AG    L C  
Sbjct: 1044 EESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV 1103

Query: 99   RGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARS 158
            +  + P P + W ++  L+   +   T L  G+       + +T     D   ++C A +
Sbjct: 1104 K--SLPPPIITWAKETQLISPFSPRHTFLPSGS-------MKITETRTSDSGMYLCVATN 1154

Query: 159  QALPTGRDT-AITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQP-PVTGYRWAKGGS 216
             A   G  T A+ L++  PP++        VQ G++V   C A   P PV    W+KGGS
Sbjct: 1155 IA---GNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVI--TWSKGGS 1209

Query: 217  PVL-----------GARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQ 265
             +L           G         +DA   T    C  +N  G+      L V   P ++
Sbjct: 1210 TMLVDGEHHVSNPDGTLSIDQATPSDAGIYT----CVATNIAGTDETEITLHVQEPPTVE 1265

Query: 266  AKPEPVSVDVGEDAS-----FSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRL 312
                P +    E  +     F C  +G P P + W   G        G  +L  G  L +
Sbjct: 1266 DLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVI 1325

Query: 313  PSVGPEDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVV---TALHSAPAFLRGPARL 367
             SV P D G+Y+C A  EAG +       +  L V+ PPV+     + +    L     L
Sbjct: 1326 ASVTPYDNGEYICVAVNEAGTT-----ERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNL 1380

Query: 368  QCLVFASPAPDAVVWSWD------EGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHI 421
             C V  +P+P  ++W  D         ++  + G+ L      PE  G         ++I
Sbjct: 1381 FCEVEGTPSP-IIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYS---CKAINI 1436

Query: 422  SGTQESDFS 430
            +GT +  F+
Sbjct: 1437 AGTSQKYFN 1445



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 89/354 (25%), Positives = 141/354 (39%), Gaps = 47/354 (13%)

Query: 38   LHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L +   E ED   Y C A+ +AG  S+   L VL PP          +S++   P  LTC
Sbjct: 3491 LQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTC 3550

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
             + G   P P++ W +DG  L      QTL      G  E  L ++    +D   + C A
Sbjct: 3551 IASGI--PAPKMTWMKDGRPLPQTDQVQTL------GGGE-VLRISTAQVEDTGRYTCLA 3601

Query: 157  RSQALPTGRDTAITLSLQYPPEVTLSASPH--TVQEGEKVIFLCQATAQPPVTGYRWAKG 214
             S A    ++  + + +  PP +  +  P   TV    +V   C++ A PP     W + 
Sbjct: 3602 SSPAGDDDKEYLVRVHV--PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV-ITWLRN 3658

Query: 215  GSPVLGARGPRLEVVADASFL---------TEPVSCEVSNAVGSANRSTALDVLFGPILQ 265
            G  +     PR+ +++   +L         T   +C  SN  G   R   L V   P ++
Sbjct: 3659 GERLQAT--PRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIK 3716

Query: 266  AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGAT--------LRLPSVGP 317
              P+ + + + +     C   G P PR+TW R+ GA + G+ A         L + S   
Sbjct: 3717 GGPQSLVILLNKSTVLECIAEGVPTPRITW-RKDGAVLAGNHARYSILENGFLHIQSAHV 3775

Query: 318  EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLV 371
             D G Y+C A         G    R+ +        +H  P+   GP  +  +V
Sbjct: 3776 TDTGRYLCMATNA-----AGTDRRRIDLQ-------VHVPPSIAPGPTNMTVIV 3817



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 83/307 (27%), Positives = 136/307 (44%), Gaps = 27/307 (8%)

Query: 38   LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L I+  +  D   Y C A  +AG  +    L V  PP   Q      VS+  G    L C
Sbjct: 757  LKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPA--DVSMEIGSNVTLPC 814

Query: 97   RSRGDARPTPELLWFR-DGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 155
              +G   P P + W R D + +    F  + + +   G++     L  ++ D G T++C 
Sbjct: 815  YVQG--YPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL---FILNLWASDKG-TYICE 868

Query: 156  ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGG 215
            A +Q      +T +T++    P + +S S   V EG+++   C   A  P+   RW K  
Sbjct: 869  AENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNS 928

Query: 216  SPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPILQAK 267
            + +L  + P + V +D S   E V        +C  SN  G+ N++T++ V   P +Q  
Sbjct: 929  AMLL--QNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHG 986

Query: 268  PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGPEDA 320
             + +S   G   +  C   GNP P V W+++G            G+  +L + S G E++
Sbjct: 987  QQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEES 1046

Query: 321  GDYVCRA 327
            G+YVC A
Sbjct: 1047 GEYVCTA 1053



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 107/442 (24%), Positives = 167/442 (37%), Gaps = 67/442 (15%)

Query: 32   ANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 90
            A+GQ  LHI+  E+ D   Y C+A   AG   +   L+V VPP     + GP   ++   
Sbjct: 3110 ADGQM-LHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPS----IEGPEREVIVET 3164

Query: 91   ---PANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHD 147
               P  LTC + G   P P + W ++   ++ +   +  +  G      S L +    H 
Sbjct: 3165 ISNPVTLTCDATGI--PPPTIAWLKNHKRIENSDSLEVRILSGG-----SKLQIARSQHS 3217

Query: 148  DGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQATAQPP 205
            D   + C A +  +         LS+Q PP V  +  P  V    GE V  +C A   P 
Sbjct: 3218 DSGNYTCIASN--MEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPT 3275

Query: 206  VTGYRWAKGGSPVLGARGPRLEVVADASFL---------TEPVSCEVSNAVGSANRSTAL 256
                +W K G P+      R+ V A+ S L         T   +C  +N  G  +R   L
Sbjct: 3276 PL-IQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNL 3334

Query: 257  DVLFGPILQA---KPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGS 306
            +V   P ++    + E +   V    +  C   G P P++ W + G         ++L +
Sbjct: 3335 NVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAA 3394

Query: 307  GATLRLPSVGPEDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAP--AFLR 362
            G  +R+      D   Y C A   AG+           L V APP +           L+
Sbjct: 3395 GQVIRIVRAQVSDVAVYTCVASNRAGVDN-----KHYNLQVFAPPNMDNSMGTEEITVLK 3449

Query: 363  GPA-RLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHI 421
            G +  + C+   +PAP     +W       G      V T            G++  L  
Sbjct: 3450 GSSTSMACITDGTPAPS---MAWLRDGQPLGLDAHLTVSTH-----------GMVLQLLK 3495

Query: 422  SGTQESDFSRSFNCSARNRLGE 443
            + T++S     + C A N  GE
Sbjct: 3496 AETEDSG---KYTCIASNEAGE 3514



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 92/370 (24%), Positives = 143/370 (38%), Gaps = 52/370 (14%)

Query: 46   EDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARP 104
            ED   Y C+A   AG   +   + VLVPP          VS+V      L C+ +G   P
Sbjct: 1424 EDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGT--P 1481

Query: 105  TPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTG 164
             P++ WF+DG  L     +  LL  G        L L     +D   + C   + A    
Sbjct: 1482 FPDIHWFKDGKPLFLGDPNVELLDRG------QVLHLKNARRNDKGRYQCTVSNAAGKQA 1535

Query: 165  RDTAITLSLQYPPEVTLS--ASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGAR 222
            +D  I L++  PP +      +  +V     +   C+ T   P+    W K G P++ + 
Sbjct: 1536 KD--IKLTIYIPPSIKGGNVTTDISVLINSLIKLECE-TRGLPMPAITWYKDGQPIMSSS 1592

Query: 223  G------------PRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQ---AK 267
                         PR +V   A++     +C V+N  G+A +S  +DV   P+++   A 
Sbjct: 1593 QALYIDKGQYLHIPRAQVSDSATY-----TCHVANVAGTAEKSFHVDVYVPPMIEGNLAT 1647

Query: 268  PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGPEDA 320
            P    V +    +  C   GNP P +TW + G         ++   G  L + S    D 
Sbjct: 1648 PLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDR 1707

Query: 321  GDYVCRAEAGLSGLRGGAAEARLTVN--APPVVTALHSAPAFL---RGPARLQCLVFASP 375
            G Y+C A +       G  E +  V+   PP +        F+        L C V  SP
Sbjct: 1708 GQYICVATS-----VAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762

Query: 376  APDAVVWSWD 385
             P  ++W  D
Sbjct: 1763 -PPTIMWLKD 1771



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 114/484 (23%), Positives = 179/484 (36%), Gaps = 64/484 (13%)

Query: 38   LHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            + I   ++ D A Y C A+ +AG+ ++   L V  PP     +G   ++++ G   ++ C
Sbjct: 3398 IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC 3457

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
             +  D  P P + W RDG  L G   H T+   G        L L     +D   + C A
Sbjct: 3458 IT--DGTPAPSMAWLRDGQPL-GLDAHLTVSTHG------MVLQLLKAETEDSGKYTCIA 3508

Query: 157  RSQALPTGRDTAITLSLQYPPEVTLSASPH--TVQEGEKVIFLCQATAQPPVTGYRWAKG 214
             ++A    +     L +  PP +  S      +V     +   C A+   P     W K 
Sbjct: 3509 SNEAGEVSKH--FILKVLEPPHINGSEEHEEISVIVNNPLELTCIASG-IPAPKMTWMKD 3565

Query: 215  GSPV--------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQA 266
            G P+        LG  G  L +       T   +C  S+  G  ++   + V   P +  
Sbjct: 3566 GRPLPQTDQVQTLGG-GEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAG 3624

Query: 267  KPEPVSVDV--GEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGP 317
              EP  + V      +  C     P P +TW R G         ++L  G  L++ +   
Sbjct: 3625 TDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADL 3684

Query: 318  EDAGDYVCRAEAGLSGLRGGAA-EARLTVNAPP-VVTALHSAPAFLRGPARLQCLVFASP 375
             D  +Y C A    S + G    E  LTVN PP +     S    L     L+C+    P
Sbjct: 3685 GDTANYTCVA----SNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVP 3740

Query: 376  APDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNC 435
             P  + W  D G + AG+  R+ +           L  G    LHI     +D  R + C
Sbjct: 3741 TP-RITWRKD-GAVLAGNHARYSI-----------LENGF---LHIQSAHVTDTGR-YLC 3783

Query: 436  SARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVI-TGVALCCWRHSKASASFS 494
             A N  G         RR +   V +   +A   T + +++     L C        S +
Sbjct: 3784 MATNAAG-------TDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSIN 3836

Query: 495  EQKN 498
             +KN
Sbjct: 3837 WRKN 3840



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 84/323 (26%), Positives = 131/323 (40%), Gaps = 43/323 (13%)

Query: 36   HDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVPAN 93
            H L ++ + + D   Y C A   AG+  +   L V  PP        P ++S+V     +
Sbjct: 2346 HILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVS 2405

Query: 94   LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 153
            LTC + G   P P + WF+DG  +  +   + L       S    L L   + +D   + 
Sbjct: 2406 LTCEASGI--PLPSITWFKDGWPVSLSNSVRIL-------SGGRMLRLMQTTMEDAGQYT 2456

Query: 154  CRARSQALPTGRDTAIT-LSLQYPPEVTLSASPHTVQEGEK--VIFLCQATAQPPVTGYR 210
            C  R+ A   G +  I  LS+  PP +    +   V+  EK  V   C+ T  P V    
Sbjct: 2457 CVVRNAA---GEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNP-VPEIT 2512

Query: 211  WAKGGSPVLGARGPRLEVVADASFL---------TEPVSCEVSNAVGSANRSTALDVLFG 261
            W K G P+         +++   FL         T   +C  S+  G  +RS +L+V   
Sbjct: 2513 WHKDGQPL--QEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVS 2570

Query: 262  PIL-----QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGAT 309
            P +        PE V+V +    S  C     P   +TW + G         ++L  G T
Sbjct: 2571 PTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRT 2630

Query: 310  LRLPSVGPEDAGDYVCRA--EAG 330
            L++ +   ++AG Y C A  EAG
Sbjct: 2631 LQILNAQEDNAGRYSCVATNEAG 2653



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 112/435 (25%), Positives = 164/435 (37%), Gaps = 61/435 (14%)

Query: 34   GQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPA 92
            G   L I   +  D   Y C AT  AG +    ++ VLVPP    + GG   S    +  
Sbjct: 1693 GGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPA---IEGGDETSYFIVMVN 1749

Query: 93   NLT---CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDG 149
            NL    C   G   P P ++W +DG L+D     + LL           L +      + 
Sbjct: 1750 NLLELDCHVTGS--PPPTIMWLKDGQLIDERDGFKILLN-------GRKLVIAQAQVSNT 1800

Query: 150  ATFVCRARSQALPTGRDTAITLSLQYPPEVTLSA-SPHTVQEGEKVIFLCQATAQPPVTG 208
              + C A + A    ++  +T+ +  PP +  S  S   V + + V   C A   P    
Sbjct: 1801 GLYRCMAANTAGDHKKEFEVTVHV--PPTIKSSGLSERVVVKYKPVALQCIANGIPN-PS 1857

Query: 209  YRWAKGGSPVLGARG-----PRLEVVADASFLTEPV---SCEVSNAVGSANRSTALDVLF 260
              W K   PV  A+G         V+  A  L E     +C  +NA G   +   L V  
Sbjct: 1858 ITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHE 1917

Query: 261  GPILQ--AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLR 311
             P L+   K    +V V       C   GNP+P +TW +             L  G  + 
Sbjct: 1918 PPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIID 1977

Query: 312  LPSVGPEDAGDYVCRAEAGLSGLRGGAAEA--RLTVNAPPVVTALHSAPA-FLRGPARLQ 368
            + S    DAG Y C A         GA E    L V+  P ++  ++  A  +  P RL+
Sbjct: 1978 IESAQISDAGIYKCVAINS-----AGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLE 2032

Query: 369  CLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESD 428
            C     PAP ++ W  D   + + S G  ++         GG       +L ++  Q SD
Sbjct: 2033 CEARGIPAP-SLTWLKDGSPVSSFSNGLQVLS--------GG------RILALTSAQISD 2077

Query: 429  FSRSFNCSARNRLGE 443
              R + C A N  GE
Sbjct: 2078 TGR-YTCVAVNAAGE 2091



 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 87/320 (27%), Positives = 126/320 (39%), Gaps = 40/320 (12%)

Query: 34   GQHDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLV---AG 89
            G   L I   ++ D   Y C A  QAG   +   L V VPP         S+S+V    G
Sbjct: 3016 GGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDH-DSESLSVVNVREG 3074

Query: 90   VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDG 149
               +L C S  +A P P + W+++G ++  +T H  +L +G        L +      D 
Sbjct: 3075 TSVSLECES--NAVPPPVITWYKNGRMITEST-HVEILADG------QMLHIKKAEVSDT 3125

Query: 150  ATFVCRARSQALPTGRDTA-ITLSLQYPPEVTLSASPHTVQE-GEKVIFLCQATAQPPVT 207
              +VCRA + A   GRD     L++  PP +        V+     V   C AT  PP T
Sbjct: 3126 GQYVCRAINVA---GRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPT 3182

Query: 208  GYRWAKG-----GSPVLGAR----GPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDV 258
               W K       S  L  R    G +L++       +   +C  SN  G A +   L +
Sbjct: 3183 -IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSI 3241

Query: 259  LFGPILQAK--PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---------GAQVLGSG 307
               P +     P  VSV +GE+    C   G P P + W + G           +V  +G
Sbjct: 3242 QVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG 3301

Query: 308  ATLRLPSVGPEDAGDYVCRA 327
            +TL +      D G Y C A
Sbjct: 3302 STLNIYGALTSDTGKYTCVA 3321



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 100/432 (23%), Positives = 161/432 (37%), Gaps = 56/432 (12%)

Query: 34   GQHDLHIRPVELEDEASYECQ-ATQAGLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVP 91
            GQ+ LHI   ++ D A+Y C  A  AG   +   + V VPP     L  P +  +V    
Sbjct: 1600 GQY-LHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHS 1658

Query: 92   ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 151
              L C++ G+  P+P L W +DGV +     +  +  E     +E    +      D   
Sbjct: 1659 LTLECKAAGN--PSPILTWLKDGVPVKA---NDNIRIEAGGKKLE----IMSAQEIDRGQ 1709

Query: 152  FVCRARSQALPTGRDTAITLSLQYPPEVT--LSASPHTVQEGEKVIFLCQATAQPPVTGY 209
            ++C A S A    ++    + +  PP +      S   V     +   C  T  PP T  
Sbjct: 1710 YICVATSVA--GEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPT-I 1766

Query: 210  RWAKGGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGP 262
             W K G  +       +   G +L +       T    C  +N  G   +   + V   P
Sbjct: 1767 MWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPP 1826

Query: 263  ILQAKPEPVSVDVG-EDASFSCAWRGNPLPRVTW--------TRRGGAQVLGSGATLRLP 313
             +++      V V  +  +  C   G P P +TW        T +G  ++  SG  L++ 
Sbjct: 1827 TIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIA 1886

Query: 314  SVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVT---ALHSAPAFLRGPARLQCL 370
                EDAG Y C A       +      +L V+ PP +     + +    +  P +L+C 
Sbjct: 1887 KTLLEDAGRYTCVATNAAGETQ---QHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECK 1943

Query: 371  VFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 430
               +P P  + W  D   L   +   FL        +RG        ++ I   Q SD +
Sbjct: 1944 AAGNPVP-VITWYKDNRLLSGSTSMTFL--------NRG-------QIIDIESAQISD-A 1986

Query: 431  RSFNCSARNRLG 442
              + C A N  G
Sbjct: 1987 GIYKCVAINSAG 1998



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 102/440 (23%), Positives = 163/440 (37%), Gaps = 59/440 (13%)

Query: 30   NAANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSL-- 86
            + +N    L I      D   Y C AT  AG       LHV  PP    +    + +   
Sbjct: 1218 HVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQE 1277

Query: 87   -VAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFS 145
             VA       C ++G  +PT  + W  +G  L G     ++L++GT   + S   +TP+ 
Sbjct: 1278 RVANQRIEFPCPAKGTPKPT--IKWLHNGRELTGREPGISILEDGTLLVIAS---VTPY- 1331

Query: 146  HDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQATAQ 203
              D   ++C A ++A  T R     L +  PP +        V     +     C+    
Sbjct: 1332 --DNGEYICVAVNEAGTTERK--YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGT 1387

Query: 204  P-PVTGYRWAKGGSPVLGA-------RGPRLEVVADASFLTEPVSCEVSNAVGSANRSTA 255
            P P+    W K    V  +        G  L++           SC+  N  G++ +   
Sbjct: 1388 PSPII--MWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFN 1445

Query: 256  LDVLFGPILQAK--PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLG 305
            +DVL  P +     P  VSV +  D +  C  +G P P + W + G          ++L 
Sbjct: 1446 IDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD 1505

Query: 306  SGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV---TALHSAPAFLR 362
             G  L L +    D G Y C   +  +G +  A + +LT+  PP +            + 
Sbjct: 1506 RGQVLHLKNARRNDKGRYQCTV-SNAAGKQ--AKDIKLTIYIPPSIKGGNVTTDISVLIN 1562

Query: 363  GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 422
               +L+C     P P A+ W  D   + + SQ  ++         +G         LHI 
Sbjct: 1563 SLIKLECETRGLPMP-AITWYKDGQPIMSSSQALYI--------DKG-------QYLHIP 1606

Query: 423  GTQESDFSRSFNCSARNRLG 442
              Q SD S ++ C   N  G
Sbjct: 1607 RAQVSD-SATYTCHVANVAG 1625



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 118/460 (25%), Positives = 170/460 (36%), Gaps = 79/460 (17%)

Query: 34   GQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQV-LGGPSVS---LVA 88
            G   L I   + ++   Y C AT +AG   +  ++ V +PP   +  L GP +S   +  
Sbjct: 2627 GGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKI 2686

Query: 89   GVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDD 148
             V   LT      A P+  L W++DG  L     H  +   G       TL +      D
Sbjct: 2687 KVNNTLTLECEAYAIPSASLSWYKDGQPLKSDD-HVNIAANG------HTLQIKEAQISD 2739

Query: 149  GATFVCRARSQALPTGRDTA-ITLSLQYPPEVT----LSASPHTVQEGEK--------VI 195
               + C A + A   G D     +++Q PP       +     T + GE         + 
Sbjct: 2740 TGRYTCVASNIA---GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPIS 2796

Query: 196  FLCQATAQPPVTGYRWAKGGSPVLGAR-------GPRLEV----VADASFLTEPVSCEVS 244
              C+  A PP T   W K G P+  +        G  L++    V DA   T    C   
Sbjct: 2797 LYCETNAAPPPT-LTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYT----CVAV 2851

Query: 245  NAVGSANRSTALDVLFGPILQAK----PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 300
            N  G  +    + VL  PI++      PE V+V V + A   C   G+P PR +W + G 
Sbjct: 2852 NEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQ 2911

Query: 301  A-------QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAE-ARLTVNAPPVVT 352
                    + L +G  L++ +    D G YVC AE       G A +   L V+ PP V 
Sbjct: 2912 PLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAE----NTAGSAKKYFNLNVHVPPSVI 2967

Query: 353  ALHS--APAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGG 410
               S      +     L C V   P PD    SW    L+     +    T   P  R  
Sbjct: 2968 GPKSENLTVVVNNFISLTCEVSGFPPPDL---SW----LKNEQPIKLNTNTLIVPGGR-- 3018

Query: 411  LGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 450
                    L I   + SD    + C A N+ GE   + SL
Sbjct: 3019 -------TLQIIRAKVSD-GGEYTCIAINQAGESKKKFSL 3050



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 91/359 (25%), Positives = 145/359 (40%), Gaps = 62/359 (17%)

Query: 31   AANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQV----------L 79
            AANG H L I+  ++ D   Y C A+  AG       +++ VPP   ++           
Sbjct: 2724 AANG-HTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGR 2782

Query: 80   GGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTL 139
             G +  ++   P +L C +  +A P P L W++DG  L  +   + L+  G  G V   L
Sbjct: 2783 NGEAKDVIINNPISLYCET--NAAPPPTLTWYKDGHPLTSS--DKVLILPG--GRV---L 2833

Query: 140  TLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQY------PPEVTLSAS----PHTVQ 189
             +     +D   + C A ++A   G D     SLQY      PP +  + S      TV 
Sbjct: 2834 QIPRAKVEDAGRYTCVAVNEA---GED-----SLQYDVRVLVPPIIKGANSDLPEEVTVL 2885

Query: 190  EGEKVIFLCQATAQPPVTGYRWAKGGSPVLG-------ARGPRLEVVADASFLTEPVSCE 242
              +  +  C ++  P      W K G P+L        + G  L+++           C 
Sbjct: 2886 VNKSALIECLSSGSPAPRN-SWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCV 2944

Query: 243  VSNAVGSANRSTALDVLFGP-ILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTR---- 297
              N  GSA +   L+V   P ++  K E ++V V    S +C   G P P ++W +    
Sbjct: 2945 AENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQP 3004

Query: 298  ---RGGAQVLGSGATLRLPSVGPEDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVV 351
                    ++  G TL++      D G+Y C A  +AG S       +  LTV  PP +
Sbjct: 3005 IKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGES-----KKKFSLTVYVPPSI 3058



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 105/433 (24%), Positives = 155/433 (35%), Gaps = 67/433 (15%)

Query: 38   LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L I   ++ +   Y C A   AG   +  ++ V VPP      G     +V   P  L C
Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSS-GLSERVVVKYKPVALQC 1848

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
             + G   P P + W +D   ++ A  +  +   G    +  TL       +D   + C A
Sbjct: 1849 IANGI--PNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLL------EDAGRYTCVA 1900

Query: 157  RSQALPTGRDTAITLSLQYPPEVTLSASP--HTVQEGEKVIFLCQATAQPPVTGYRWAKG 214
             + A  T +   I L +  PP +  +      TV     V   C+A   P V    W K 
Sbjct: 1901 TNAAGETQQH--IQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNP-VPVITWYKD 1957

Query: 215  GSPVLGA-------RGPRLEV----VADASFLTEPVSCEVSNAVGSANRSTALDVLFGPI 263
               + G+       RG  +++    ++DA        C   N+ G+     +L V   P 
Sbjct: 1958 NRLLSGSTSMTFLNRGQIIDIESAQISDAGIY----KCVAINSAGATELFYSLQVHVAPS 2013

Query: 264  LQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRLPSV 315
            +      V+V V       C  RG P P +TW + G        G QVL  G  L L S 
Sbjct: 2014 ISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSA 2073

Query: 316  GPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASP 375
               D G Y C A    +G +    + R+ V  P ++    +    +     L C   A P
Sbjct: 2074 QISDTGRYTCVA-VNAAGEKQRDIDLRVYV-PPNIMGEEQNVSVLISQAVELLCQSDAIP 2131

Query: 376  APDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLI-----SVLHISGTQESDFS 430
             P  + W  D         G  L++            PGL      SVL I   Q  D  
Sbjct: 2132 -PPTLTWLKD---------GHPLLKK-----------PGLSISENRSVLKIEDAQVQDTG 2170

Query: 431  RSFNCSARNRLGE 443
            R + C A N  G+
Sbjct: 2171 R-YTCEATNVAGK 2182



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 81/369 (21%), Positives = 145/369 (39%), Gaps = 51/369 (13%)

Query: 38  LHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVPANLTC 96
           L ++ V+  D   Y C  +  G  S  +    L   E P+V   P + S   G   ++ C
Sbjct: 576 LELKSVKFNDAGEYHCMVSSEGGSSAASVF--LTVQEPPKVTVMPKNQSFTGGSEVSIMC 633

Query: 97  RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
            + G   P P++ W  + + + G+  ++         + + TL +   +  D   + C A
Sbjct: 634 SATG--YPKPKIAWTVNDMFIVGSHRYRM--------TSDGTLFIKNAAPKDAGIYGCLA 683

Query: 157 RSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGG- 215
            + A    +++  TL     P++ +  S   V  G+  +  C+ +  PP    +W KG  
Sbjct: 684 SNSAGTDKQNS--TLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQ-VKWFKGDL 740

Query: 216 ----------SPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQ 265
                      P+LG     L++           +C   N  G A     LDV   P+  
Sbjct: 741 ELRPSTFLIIDPLLGL----LKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFI 796

Query: 266 AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQV------------LGSGATLRLP 313
            +P  VS+++G + +  C  +G P P + W R     +            L +GA L + 
Sbjct: 797 QEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGA-LFIL 855

Query: 314 SVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVN--APPVVTALHSAPAFLRG-PARLQCL 370
           ++   D G Y+C AE     ++   +E  +TV     P++    S    + G    L C 
Sbjct: 856 NLWASDKGTYICEAENQFGKIQ---SETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCT 912

Query: 371 VFA-SPAPD 378
           + A +P P+
Sbjct: 913 LLAGNPIPE 921



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 78/308 (25%), Positives = 119/308 (38%), Gaps = 36/308 (11%)

Query: 37   DLHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLT 95
            +L +  V LED   Y C A  A G  +    L V V P   ++ G   VSL  G    L+
Sbjct: 4223 ELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG--DVSLNKGEQLRLS 4280

Query: 96   CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPG-SVESTLTLTPFSHDDGATFVC 154
            C++ G   P P+L W          TF+  ++       +  S L +   S +D  T+VC
Sbjct: 4281 CKATGI--PLPKLTW----------TFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVC 4328

Query: 155  RARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQATAQPPVTGYRWA 212
             A +     G   AI       P V     P    E  G   I  C+    P  T  +W 
Sbjct: 4329 TAENSV---GFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPT-IQWN 4384

Query: 213  KGGSPVLGARGPR------LEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQA 266
            + G  +  +   R      L +    +      +C  +N  G   RS +L +   PI+  
Sbjct: 4385 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4444

Query: 267  KPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGA-------QVLGSGATLRLPSVGPED 319
            +P    ++ G     +C   G P P +TW+R+G +        VL S  +L +     ED
Sbjct: 4445 EPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVL-SNNSLYIADAQKED 4503

Query: 320  AGDYVCRA 327
              ++ C A
Sbjct: 4504 TSEFECVA 4511



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 46/160 (28%), Positives = 64/160 (40%), Gaps = 17/160 (10%)

Query: 241 CEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 300
           C   ++ G+    T  DV   P +   P  V+V  GE A  +C         +TW R   
Sbjct: 499 CIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDR 558

Query: 301 AQVLGSGATLR--------LPSVGPEDAGDYVC--RAEAGLSGLRGGAAEARLTVNAPPV 350
              L   A +R        L SV   DAG+Y C   +E G S     AA   LTV  PP 
Sbjct: 559 DVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSS-----AASVFLTVQEPPK 613

Query: 351 VTALHSAPAFLRG-PARLQCLVFASPAPDAVVWSWDEGFL 389
           VT +    +F  G    + C     P P  + W+ ++ F+
Sbjct: 614 VTVMPKNQSFTGGSEVSIMCSATGYPKP-KIAWTVNDMFI 652


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  102 bits (253), Expect = 1e-21
 Identities = 115/412 (27%), Positives = 163/412 (39%), Gaps = 61/412 (14%)

Query: 51   YECQA-TQAGLRSRPAQLHVLVPPEA-PQVLGGPSV-SLVAGVPANLTCRSRGDARPTPE 107
            Y C A   AG+    A  HV +  +A P V   PSV   VA     L C + G  RPT  
Sbjct: 2734 YTCSARNSAGV----AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPT-- 2787

Query: 108  LLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDT 167
            + W ++G+ +      Q L     PG     L +   S +D   ++C A++ A      T
Sbjct: 2788 ITWQKEGLNVATGVSTQVL-----PGG---QLRIAHASPEDAGNYLCIAKNSAGSAMGKT 2839

Query: 168  AITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLE 227
             + +  Q PP +       +  EG      C+A   P      W K G PV GA G +  
Sbjct: 2840 RLVV--QVPPVIENGLPDLSTTEGSHAFLPCKARGSPE-PNITWDKDGQPVSGAEG-KFT 2895

Query: 228  VVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDA 279
            +      L + +        +C   NAVG A R   L +L  P+    P   S+ +G+  
Sbjct: 2896 IQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRL 2955

Query: 280  SFSCAWRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGL 334
               CA RG+P PR+ WT        G      G+TL+  +V  ED+G YVC AE      
Sbjct: 2956 WLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN----- 3010

Query: 335  RGGAAEARLTVNAPPVVTALHSAPAFL----RGPARLQCLVFASPAPDAVVWSWDEGFLE 390
            R G  +A   V+          A ++L     G  +L C+V   P PD + W  D G   
Sbjct: 3011 RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD-IHWIKD-GLPL 3068

Query: 391  AGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLG 442
             GS  R  ++                  L I  T+  D  R + C A N +G
Sbjct: 3069 RGSHLRHQLQN---------------GSLTIHRTERDDAGR-YQCLAENEMG 3104



 Score =  101 bits (252), Expect = 2e-21
 Identities = 107/393 (27%), Positives = 150/393 (38%), Gaps = 59/393 (15%)

Query: 26   WISGNAANGQHDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEA--PQVLGGP 82
            W+    +     L I   +L D  SY C A+  AG       L V VPP    P  L GP
Sbjct: 738  WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGP 797

Query: 83   SVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVE----ST 138
               ++   P  LTC + G   P+P L+W +DG  +  A         GTPG         
Sbjct: 798  ---VLVNTPVRLTCNATG--APSPTLMWLKDGNPVSPA---------GTPGLQVFPGGRV 843

Query: 139  LTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLC 198
            LTL      D   + C A S      +D  + L +  PP +       +V   E V   C
Sbjct: 844  LTLASARASDSGRYSCVAVSAVGEDRQD--VVLQVHMPPSILGEELNVSVVANESVALEC 901

Query: 199  QATAQPPVTGYRWAKGGSPVLGARGPRLEV-----------VADASFLTEPVSCEVSNAV 247
            Q+ A PP     W K G P+    G  L             V DA   T    CE  N  
Sbjct: 902  QSHAMPPPV-LSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYT----CEALNQA 956

Query: 248  GSANRSTALDVLFGPILQAKPE-PVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS 306
            G + +   L+V   P+   +    ++V  G   S SC  RG P P+++W R+ G  + G 
Sbjct: 957  GRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISW-RKDGQPLPGE 1015

Query: 307  GATLR-LPSVGP---------EDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS 356
            GA L+ + +VG             G Y C      + +   + + +L V+ PP +     
Sbjct: 1016 GAGLQHVSAVGRLLYLGQAQLAQEGTYTCECS---NVVGNSSQDLQLEVHVPPQIAGPRE 1072

Query: 357  APAFLR----GPARLQCLVFASPAPDAVVWSWD 385
             P  +     G A L+C     P P  V W  D
Sbjct: 1073 PPTQVSVVQDGVATLECNATGKP-PPTVTWERD 1104



 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 116/418 (27%), Positives = 159/418 (38%), Gaps = 57/418 (13%)

Query: 58  AGLRSRPAQLHVLVPPEAPQVLGGPSVSLV---AGVPANLTCRSRGDARPTPELLWFRDG 114
           AG    P   H   PP  P VLG  +   V   AG    L C + G   PTP++ W +D 
Sbjct: 199 AGFEQFPTP-HAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGV--PTPQVEWTKDR 255

Query: 115 VLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQ 174
             +     H  + ++G        L +T     D   + C A S A    RD    L + 
Sbjct: 256 QPVLPGGPHLQVQEDG------QVLRITGSHVGDEGRYQCVAFSPAGQQARD--FQLRVH 307

Query: 175 YPPEVTLS--ASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGS------PVLGARGPR- 225
            PP +  S       V E   V  LC+A   P      W K G+       V+  RG R 
Sbjct: 308 APPTIWGSNETGEVAVMEDHLVQLLCEARGVP-TPNITWFKDGALLPTSTKVVYTRGGRQ 366

Query: 226 LEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQ---AKPEPVSVDVGEDASFS 282
           L++    S      +C+ SNAVG+A ++T LDV   P ++    +P  V    G   +  
Sbjct: 367 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALE 426

Query: 283 CAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLR 335
           C  RG+P P ++W   G        +++   G+ LRL S G   +G Y C A    S   
Sbjct: 427 CVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS---SPAG 483

Query: 336 GGAAEARLTVNAPP---VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAG 392
               +  + V  PP   V   L      +  P  L C    SP P  + W      L+ G
Sbjct: 484 EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVP-TIQW------LQNG 536

Query: 393 SQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 450
                     PA E  G       + LHI    E D S  F C A N  G  GA+  +
Sbjct: 537 R---------PAEELAGVQVASQGTTLHIDHV-ELDHSGLFACQATNEAGTAGAEVEV 584



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 126/433 (29%), Positives = 170/433 (39%), Gaps = 62/433 (14%)

Query: 38   LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L +   E+ D ASY C A  QAG   +   L V VPP     L    V+ +     +L C
Sbjct: 1710 LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAG-LDLEQVTAILNSSVSLPC 1768

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
                 A P PE+ W++D   L  +   +  L  GT      TL L      D   + C A
Sbjct: 1769 DVH--AHPNPEVTWYKDSQAL--SLGEEVFLLPGT-----HTLQLGRARLSDSGMYTCEA 1819

Query: 157  RSQALPTGRD-TAITLSLQYPPEVTLSASPHTVQE------GEKVIFLCQATAQPPVTGY 209
             + A   GRD   + LS+  PP      +P   Q+      G+K +  C+  A P  T  
Sbjct: 1820 LNAA---GRDQKLVQLSVLVPP--AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-V 1873

Query: 210  RWAKGGSPVLGAR-------GPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGP 262
             W K G P++ A+       G RLE+           SC+VSN  G A R+  L V   P
Sbjct: 1874 TWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPP 1933

Query: 263  ILQ-AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTR-------RGGAQVLGSGATLRLPS 314
              +  K E VS   G     +C   G P P VTW +            V+  G  L+L  
Sbjct: 1934 TFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSR 1993

Query: 315  VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPV-VTALHSAPAFLRG-PARLQCLVF 372
            + P  AG Y C AE   +  R     A L   AP +  + +      L G   RL C   
Sbjct: 1994 LQPAQAGTYTCVAENTQAEARKDFVVAVLV--APRIRSSGVAREHHVLEGQEVRLDCEAD 2051

Query: 373  ASPAPDAVVWSWDEGFL--EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFS 430
              P PD V W  D   L  + G   RF ++        GG        L + G + SD +
Sbjct: 2052 GQPPPD-VAWLKDGSPLGQDMGPHLRFYLD--------GG-------SLVLKGLRASD-A 2094

Query: 431  RSFNCSARNRLGE 443
             ++ C A N  GE
Sbjct: 2095 GAYTCVAHNPAGE 2107



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 132/499 (26%), Positives = 203/499 (40%), Gaps = 84/499 (16%)

Query: 30  NAANGQHDLHIRPVELEDEAS---YECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS 85
           N +  + D  +  +E   EAS   Y C A+  AG       + V VPP+     G   V+
Sbjct: 450 NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVT 509

Query: 86  LVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFS 145
            + G P  L C++ G   P P + W ++G   +     Q +  +GT      TL +    
Sbjct: 510 TIVGQPLELPCQASGS--PVPTIQWLQNGRPAEELAGVQ-VASQGT------TLHIDHVE 560

Query: 146 HDDGATFVCRARSQALPTGRDTAITLSLQYPP---EVTLSASPHTVQEGEKVIFLCQ--- 199
            D    F C+A ++A   G +  +++  ++ P   EV +       +        C    
Sbjct: 561 LDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPV 620

Query: 200 -----ATAQPPVT------GYRWAKG-GSPVLGARGPRLEV----VADASFLTEPVSCEV 243
                A  +PP+       G  W +  G PV  +  P L++    + D    T    C  
Sbjct: 621 HRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYT----CAA 676

Query: 244 SNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDAS--FSCAWRGNPLPRVTWTRRG-- 299
           +N  G + R  AL VL  P ++  P PV+  V E+AS    C   G P P V+W +    
Sbjct: 677 TNLAGESKREVALKVLVPPNIE--PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQP 734

Query: 300 -----GAQVLGSGATLRLPSVGPEDAGDYVCRAE--AGLSGLRGGAAEARLTVNAPPVVT 352
                G  V   G  LR+      DAG Y C A   AG + LR G     L VN PP +T
Sbjct: 735 VSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-----LRVNVPPRIT 789

Query: 353 ALHS--APAFLRGPARLQCLVFASPAPDAVVWSWDEGFLE-AGSQGRFLVETFPAPESRG 409
              S   P  +  P RL C    +P+P  ++W  D   +  AG+ G   ++ FP     G
Sbjct: 790 LPPSLPGPVLVNTPVRLTCNATGAPSP-TLMWLKDGNPVSPAGTPG---LQVFP-----G 840

Query: 410 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAAT 469
           G       VL ++  + SD  R ++C A + +GE        R+D++  V +   +    
Sbjct: 841 G------RVLTLASARASDSGR-YSCVAVSAVGE-------DRQDVVLQVHMPPSILGEE 886

Query: 470 TTLLMVIT-GVALCCWRHS 487
             + +V    VAL C  H+
Sbjct: 887 LNVSVVANESVALECQSHA 905



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 115/445 (25%), Positives = 171/445 (38%), Gaps = 83/445 (18%)

Query: 38   LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPANLT 95
            L++   +L  E +Y C+ +   G  S+  QL V VPP+       P+ VS+V    A L 
Sbjct: 1029 LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 1088

Query: 96   CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 155
            C + G  +P P + W RDG  + GA     L  +G    VE                   
Sbjct: 1089 CNATG--KPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVE------------------- 1126

Query: 156  ARSQALPTGRDTAIT------------LSLQYPPEVTLSASPHT---VQEGEKVIFLCQA 200
             R+QA  TGR + +             LS+  PPE+     P T         +  LC+A
Sbjct: 1127 -RAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEA 1185

Query: 201  TAQPPVTGYRWAKGGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRS 253
               PP    RW +G  PV       L A G  L++       +   SC  SN  G A R+
Sbjct: 1186 MGIPP-PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRN 1244

Query: 254  TALDVLFGPILQAKP--EPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLG------ 305
             +++VL  P ++ +   E + V  G+ A   C   G+P P++TW + G     G      
Sbjct: 1245 FSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHIS 1304

Query: 306  -SGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV------TALHSAP 358
              G  L++       AG Y C A    + +       +L+V   P +      +A     
Sbjct: 1305 PDGVLLQVLQANLSSAGHYSCIA---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVT 1361

Query: 359  AFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISV 418
              +  P  L C   A P+P+ + W  D    EA    + L      P + G         
Sbjct: 1362 VTVNNPISLICEALAFPSPN-ITWMKDGAPFEASRNIQLL------PGTHG--------- 1405

Query: 419  LHISGTQESDFSRSFNCSARNRLGE 443
            L I   Q+ D +  + C   N LGE
Sbjct: 1406 LQILNAQKED-AGQYTCVVTNELGE 1429



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 110/426 (25%), Positives = 162/426 (38%), Gaps = 59/426 (13%)

Query: 38   LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L +  V   D  +Y C A ++AG   R  QL V+ PP          +SL  G P  L C
Sbjct: 2267 LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLC 2326

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
             ++G   P P + W +DG         Q L +          L +      D   + C A
Sbjct: 2327 DAQGT--PQPNITWHKDG---------QALTRLENNSRATRVLRVR-----DAGLYTCLA 2370

Query: 157  RSQALPTGR-DTAITLSLQYPPEVTLSASPHTVQ--EGEKVIFLCQATAQPPVTGYRWAK 213
             S   P G  + +  + +Q PP +     P  V      +++  C   A+P      W +
Sbjct: 2371 ES---PAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEP-APKITWHR 2426

Query: 214  GGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQA 266
             G  +          RG  L++ A ++  +   SC   NA GS + +  +++   P +++
Sbjct: 2427 DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS 2486

Query: 267  KPEPVSVDVGEDASFSCAWRGNPLPRVTW--------TRRGGAQVLGSGATLRLPSVGPE 318
             P  V+V V + A   C   G P P V+W         R    ++L  G +LR+  V  +
Sbjct: 2487 GPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG-SLRIQPVLAQ 2545

Query: 319  DAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS-APAFLRGPARLQCLVFASPAP 377
            DAG Y+C A       R G     L V  PP +    S        PA L C    SP P
Sbjct: 2546 DAGHYLCLASNSAGSDRQG---RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKP 2602

Query: 378  DAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSA 437
              VVW W +G              F   +    L P    +L   G Q+   S  F C  
Sbjct: 2603 -LVVW-WKDG----------QKLDFRLQQGAYRLLPSNALLLTAPGPQD---SAQFECVV 2647

Query: 438  RNRLGE 443
             N +GE
Sbjct: 2648 SNEVGE 2653



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 130/490 (26%), Positives = 178/490 (36%), Gaps = 77/490 (15%)

Query: 29  GNAANGQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLV 87
           G A   +  L +  V   D   YECQAT + G  SR A+L V VPP   +     +VS +
Sbjct: 50  GVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGM 109

Query: 88  AGVPANLTCRSRGDARPTPELLWFRDGVLLD--------------GATFHQTLLKEGTPG 133
           AG    L C + G   P PE++W +D  L+               G      LL EG   
Sbjct: 110 AGQSLTLECDANG--FPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ-- 165

Query: 134 SVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEG-- 191
           S+         S   GA     A+++A P     A       P   +  A P  +  G  
Sbjct: 166 SLHFPRIQPGRSGRRGAQAGGSAQTKA-PWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAA 224

Query: 192 EKVIFLCQA-------TAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS---- 240
           ++V+ L  A       T+  P     W K   PVL   GP L+V  D   L    S    
Sbjct: 225 QEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG-GPHLQVQEDGQVLRITGSHVGD 283

Query: 241 -----CEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGED--ASFSCAWRGNPLPRV 293
                C   +  G   R   L V   P +    E   V V ED      C  RG P P +
Sbjct: 284 EGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 343

Query: 294 TWTRRGGAQVLGS-------GATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAE--ARLT 344
           TW + G      +       G  L+L      DAG Y C+A   +     GAAE   RL 
Sbjct: 344 TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAV-----GAAEKATRLD 398

Query: 345 VNAPPVVTALHSAPAFLRG----PARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVE 400
           V  PP +      P  ++     P  L+C+    P+P     SW    L         +E
Sbjct: 399 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP---TLSWHHEGLPVAESNESRLE 455

Query: 401 TFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVR 460
           T               SVL +    E+  S  ++C A +  GE   Q S+    + P + 
Sbjct: 456 TDG-------------SVLRLESPGEAS-SGLYSCVASSPAGEAVLQYSV-EVQVPPQLL 500

Query: 461 IVAGVAAATT 470
           +  G+   TT
Sbjct: 501 VAEGLGQVTT 510



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 132/482 (27%), Positives = 184/482 (38%), Gaps = 78/482 (16%)

Query: 34   GQHDLHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGP-SVSLVAGVP 91
            G   L +      D   Y C A  A G   +   L V +PP    +LG   +VS+VA   
Sbjct: 840  GGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS---ILGEELNVSVVANES 896

Query: 92   ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHD-DGA 150
              L C+S   A P P L W++DG  L+         + G   S +  L     +   D  
Sbjct: 897  VALECQSH--AMPPPVLSWWKDGRPLEP--------RPGVHLSADKALLQVDRADVWDAG 946

Query: 151  TFVCRARSQALPTGR-DTAITLSLQYPPEVTLSASPH-TVQEGEKVIFLCQATAQPPVTG 208
             + C A +QA   GR +    L++   P   L  S   TV+EG      C+    P    
Sbjct: 947  HYTCEALNQA---GRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVP-FPK 1002

Query: 209  YRWAKGGSPVLGARGP--------RLEVVADASFLTEPV-SCEVSNAVGSANRSTALDVL 259
              W K G P+ G            RL  +  A    E   +CE SN VG++++   L+V 
Sbjct: 1003 ISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVH 1062

Query: 260  FGPILQAKPEP-VSVDVGED--ASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGAT 309
              P +    EP   V V +D  A+  C   G P P VTW R G       G Q+   G +
Sbjct: 1063 VPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQS 1122

Query: 310  LRLPSVGPEDAGDYVCRAEAGLSGLRGGA-AEARLTVNAPPVVTA----LHSAPAFLRGP 364
            L +        G Y C AE     L G A  +  L+V  PP +      L +  A L  P
Sbjct: 1123 LHVERAQAAHTGRYSCVAE----NLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP 1178

Query: 365  ARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGT 424
              L C     P P A+ W   E  +  G     L          GG       +L ++ T
Sbjct: 1179 LTLLCEAMGIP-PPAIRWFRGEEPVSPGEDTYLLA---------GGW------MLKMTQT 1222

Query: 425  QESDFSRSFNCSARNRLGEGG--------AQASLGRRDLLPTVRIVAGVAAATTTLLMVI 476
            QE D S  ++C A N  GE             S+   DL   ++++ G    T  L+  +
Sbjct: 1223 QEQD-SGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDG---QTAHLMCNV 1278

Query: 477  TG 478
            TG
Sbjct: 1279 TG 1280



 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 107/409 (26%), Positives = 154/409 (37%), Gaps = 66/409 (16%)

Query: 34   GQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQ--VLGGPSVSLV-AG 89
            G H L I   + ED   Y C  T + G   +   + VL+PP   +   LG   V  V   
Sbjct: 1402 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTK 1461

Query: 90   VPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDG 149
            V + LT      A P P + W++DG  +  ++  Q +L EG        L + P    D 
Sbjct: 1462 VNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQ-VLGEG------RLLQIQPTQVSDS 1514

Query: 150  ATFVCRARSQALPTGRDTAITLSLQYPPEV-----------TLSASPHT---------VQ 189
              ++C A + A    +D    + +Q PP              LS              + 
Sbjct: 1515 GRYLCVATNVAGEDDQD--FNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 1572

Query: 190  EGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPV---------S 240
            E       C   A PP     W +   P+  + G  + V+     L  P+         S
Sbjct: 1573 ENNPAYLYCDTNAIPP-PDLTWYREDQPL--SAGDEVSVLQGGRVLQIPLVRAENAGRYS 1629

Query: 241  CEVSNAVGSANRSTALDVLFGPIL----QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWT 296
            C+ SN VG       L VL  P++    +   E V+V+     S  C   GNP+P ++W 
Sbjct: 1630 CKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL 1689

Query: 297  RRG-------GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLT--VNA 347
            + G         QVL  G  L++ +    DA  Y+C AE      + G+AE   T  V  
Sbjct: 1690 QNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAEN-----QAGSAEKLFTLRVQV 1744

Query: 348  PPVVTA--LHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQ 394
            PP +    L    A L     L C V A P P+ V W  D   L  G +
Sbjct: 1745 PPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPE-VTWYKDSQALSLGEE 1792



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 105/372 (28%), Positives = 139/372 (37%), Gaps = 46/372 (12%)

Query: 38   LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L I  V+L DE  Y C AT  AG   R   L VLVPP      G  + +++      L C
Sbjct: 659  LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEP--GPVNKAVLENASVTLEC 716

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLK-EGTPGSVES-TLTLTPFSHDDGATFVC 154
             + G   P P++ WF+          HQ +    G   SV+   L +      D  ++ C
Sbjct: 717  LASGV--PPPDVSWFKG---------HQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC 765

Query: 155  RARSQALPTGRDTAITLSLQYPPEVTLSAS-PHTVQEGEKVIFLCQATAQPPVTGYRWAK 213
             A + A  T  +    L +  PP +TL  S P  V     V   C AT  P  T   W K
Sbjct: 766  VASNVAGST--ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLK 822

Query: 214  GGSPVLGARGPRLEVVADASFLTEP---------VSCEVSNAVGSANRSTALDVLFGPIL 264
             G+PV  A  P L+V      LT            SC   +AVG   +   L V   P +
Sbjct: 823  DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 882

Query: 265  QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVGP 317
              +   VSV   E  +  C     P P ++W + G       G  +    A L++     
Sbjct: 883  LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADV 942

Query: 318  EDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR--GPARLQCLVFA 373
             DAG Y C A  +AG S          L V   PV     S    +R   P  L C    
Sbjct: 943  WDAGHYTCEALNQAGRS-----EKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRG 997

Query: 374  SPAPDAVVWSWD 385
             P P  + W  D
Sbjct: 998  VPFP-KISWRKD 1008



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 114/436 (26%), Positives = 163/436 (37%), Gaps = 60/436 (13%)

Query: 34   GQHDLHIRPVELEDEASYECQATQAGLRSRP-AQLHVLVPPEAPQVLGGP--SVSLVAGV 90
            G H L +    L D   Y C+A  A  R +   QL VLVPP   Q   GP  +V +  G 
Sbjct: 1798 GTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGD 1857

Query: 91   PANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGA 150
             A L+C +  DA P P + W++DG  L  A   Q  L+ G        L +      D  
Sbjct: 1858 KAVLSCET--DALPEPTVTWYKDGQPLVLAQRTQA-LRGG------QRLEIQEAQVSDKG 1908

Query: 151  TFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE--GEKVIFLCQATAQPPVTG 208
             + C+  + A    R    TL++Q PP    +    TV +  G  ++  C  +  P  T 
Sbjct: 1909 LYSCKVSNVAGEAVR--TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPT- 1964

Query: 209  YRWAKGGSPV-------LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFG 261
              W K   PV       + +RG RL++           +C   N    A +   + VL  
Sbjct: 1965 VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA 2024

Query: 262  PILQAK--PEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG--AQVLG-------SGATL 310
            P +++        V  G++    C   G P P V W + G    Q +G        G +L
Sbjct: 2025 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 2084

Query: 311  RLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARL-TVNA---PPVVTALHSAPAFLRGPAR 366
             L  +   DAG Y C A            +ARL TVN    P +      +   +  P  
Sbjct: 2085 VLKGLRASDAGAYTCVAH------NPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGE 2138

Query: 367  LQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQE 426
            L  +V        +  SW             L +  P P S+  L  G    L IS  Q 
Sbjct: 2139 LVTMVCPVRGSPPIHVSW-------------LKDGLPLPLSQRTLLHGSGHTLRISKVQL 2185

Query: 427  SDFSRSFNCSARNRLG 442
            +D +  F C A +  G
Sbjct: 2186 AD-AGIFTCVAASPAG 2200



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 102/372 (27%), Positives = 140/372 (37%), Gaps = 51/372 (13%)

Query: 36   HDLHIRPVELEDEASYEC-QATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANL 94
            H L I  V+L D   + C  A+ AG+  R   L V VPP    V     V +V G    L
Sbjct: 2176 HTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVEL 2235

Query: 95   TCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 154
             C +RG   P P + W +DG  L   +  Q             +L L      D  T+ C
Sbjct: 2236 PCEARG--VPLPLVSWMKDGEPLLSQSLEQ-----------GPSLQLEAVGAGDSGTYSC 2282

Query: 155  RARSQALPTGRDTAITLSLQYPPEVTLSASPH--TVQEGEKVIFLC--QATAQPPVTGYR 210
             A S+A    R     L++  PP +  S  P   ++  G  +  LC  Q T QP +T   
Sbjct: 2283 VAVSEAGEARRH--FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--- 2337

Query: 211  WAKGGSPVL----GARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQA 266
            W K G  +      +R  R+  V DA   T    C   +  G+  +S  + V   P +  
Sbjct: 2338 WHKDGQALTRLENNSRATRVLRVRDAGLYT----CLAESPAGAIEKSFRVRVQAPPNIVG 2393

Query: 267  KPEP---VSVDVGEDASFSCAWRGNPLPRVTWTRRG-------GAQVLGSGATLRLPSVG 316
               P   V +  G+     C+    P P++TW R G         Q    G  L+L ++ 
Sbjct: 2394 PRGPRFVVGLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALS 2452

Query: 317  PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAF---LRGPARLQCLVFA 373
              D+GDY C A         G+      V    V T     PA    +   A L C    
Sbjct: 2453 TADSGDYSCTARNA-----AGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADG 2507

Query: 374  SPAPDAVVWSWD 385
             PAP  V W  D
Sbjct: 2508 VPAP-LVSWRKD 2518



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 91/333 (27%), Positives = 133/333 (39%), Gaps = 45/333 (13%)

Query: 37   DLHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLT 95
            +L ++ +E +D  +Y C A  A G   R   L +LV P    + G  S+ L  G    L 
Sbjct: 2901 ELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLR 2958

Query: 96   CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG-TPGSVESTLTLTPFSHDDGATFVC 154
            C +RG   PTP + W          T +   + EG +     STL     S +D  T+VC
Sbjct: 2959 CAARGS--PTPRIGW----------TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVC 3006

Query: 155  RARSQALPTGRDTAIT-LSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 213
             A ++    GR  A++ + ++  P +   A  + V+     I L       PV    W K
Sbjct: 3007 WAENRV---GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIK 3063

Query: 214  GGSPVLGARGPRLEVVADASFLT---------EPVSCEVSNAVGSANRSTALDVLFGPIL 264
             G P+   RG  L        LT             C   N +G A +   L +   P+ 
Sbjct: 3064 DGLPL---RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 3120

Query: 265  QAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLR--------LPSVG 316
            Q +P+ ++V  G+D +  C   G P P + W + G  Q L +   LR        L +V 
Sbjct: 3121 QVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG--QPLRASRRLRTLPDGSLWLENVE 3178

Query: 317  PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP 349
              DAG Y C A    + L    A A L V   P
Sbjct: 3179 TGDAGTYDCVAH---NLLGSATARAFLVVRGEP 3208



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 100/372 (26%), Positives = 144/372 (38%), Gaps = 54/372 (14%)

Query: 38   LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L ++ +   D   Y C A  A G  S   ++ +   P      G P+V++     A L C
Sbjct: 2446 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRS--GPPAVNVSVNQTALLPC 2503

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
            ++  D  P P + W +D V LD  +    +L EG+       L + P    D   ++C A
Sbjct: 2504 QA--DGVPAPLVSWRKDRVPLDPRSPRFEILPEGS-------LRIQPVLAQDAGHYLCLA 2554

Query: 157  RSQALPT--GRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG 214
             + A     GRD    L +  PP +  S S  T+      +  C+A+  P      W  G
Sbjct: 2555 SNSAGSDRQGRD----LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG 2610

Query: 215  GSPVLGAR-GPRLEVVADASFLTEP-------VSCEVSNAVGSANRSTALDVLFGPILQA 266
                   + G    + ++A  LT P         C VSN VG A+R   + V   P +  
Sbjct: 2611 QKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD 2670

Query: 267  KPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG--------GAQVLGSGATLRLPSVGPE 318
                 +V +      +C   G P P V+W++ G        G +V  SGA L +    P 
Sbjct: 2671 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGA-LEIGQALPI 2729

Query: 319  DAGDYVCRAEAGLSGLRGGAAEAR----LTVNAPPVVTALHSAPAFLRGPAR----LQCL 370
             AG Y C A       R  A  A     LTV A PVV  L   P+ +R  A     L C 
Sbjct: 2730 HAGRYTCSA-------RNSAGVAHKHVFLTVQASPVVKPL---PSVVRAVAEEEVLLPCE 2779

Query: 371  VFASPAPDAVVW 382
                P P  + W
Sbjct: 2780 ASGIPRP-TITW 2790



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 107/456 (23%), Positives = 168/456 (36%), Gaps = 84/456 (18%)

Query: 38   LHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L +   + +D   Y C A+ +AG   R   + VLVPP          + ++ G  A+L C
Sbjct: 1217 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMC 1276

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
               G   P P+L WF+DG  L     H       +P  V   L +   +      + C A
Sbjct: 1277 NVTG--HPQPKLTWFKDGRPLARGDAHHI-----SPDGV--LLQVLQANLSSAGHYSCIA 1327

Query: 157  RSQALPTGRDTA-ITLSLQYPPEVTLSASPH-----TVQEGEKVIFLCQATAQPPVTGYR 210
               A   G  T    LS+   P +   A        TV     +  +C+A A P      
Sbjct: 1328 ---ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPS-PNIT 1383

Query: 211  WAKGGSPVLGARGPRL-------EVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPI 263
            W K G+P   +R  +L       +++          +C V+N +G A ++  ++VL  P 
Sbjct: 1384 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1443

Query: 264  LQAKPEP--------VSVDVGEDASFSCAWRGNPLPRVTWTRRGGA-------QVLGSGA 308
            + +K +P        V   V    +  C     P P + W + G         QVLG G 
Sbjct: 1444 I-SKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 1502

Query: 309  TLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFL------- 361
             L++      D+G Y+C A   ++G      +  + +  PP+   +    A         
Sbjct: 1503 LLQIQPTQVSDSGRYLCVA-TNVAG--EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 1559

Query: 362  --------------RGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPES 407
                            PA L C   A P PD + W  ++  L AG +   L         
Sbjct: 1560 EARGGVTEYREIVENNPAYLYCDTNAIPPPD-LTWYREDQPLSAGDEVSVL--------- 1609

Query: 408  RGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 443
            +GG       VL I   +  +  R ++C A N +GE
Sbjct: 1610 QGG------RVLQIPLVRAENAGR-YSCKASNEVGE 1638



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 120/458 (26%), Positives = 164/458 (35%), Gaps = 93/458 (20%)

Query: 38   LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQV----------------LG 80
            L I+P ++ D   Y C AT  AG   +   + + VPP   +V                 G
Sbjct: 1504 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARG 1563

Query: 81   GPSV--SLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST 138
            G +    +V   PA L C +  +A P P+L W+R+   L  A    ++L+ G        
Sbjct: 1564 GVTEYREIVENNPAYLYCDT--NAIPPPDLTWYREDQPL-SAGDEVSVLQGG------RV 1614

Query: 139  LTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQE-----GEK 193
            L +     ++   + C+A ++    G D      L   P V L  +   V+E        
Sbjct: 1615 LQIPLVRAENAGRYSCKASNE---VGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 1671

Query: 194  VIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS---------CEVS 244
            V   C A    PV    W + G P   +  PRL+V+ D   L    +         C   
Sbjct: 1672 VSLQCPALGN-PVPTISWLQNGLPF--SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 1728

Query: 245  NAVGSANRSTALDVLFGP-ILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQV 303
            N  GSA +   L V   P I     E V+  +    S  C    +P P VTW +   A  
Sbjct: 1729 NQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALS 1788

Query: 304  LGSGA-------TLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHS 356
            LG          TL+L      D+G Y C A   L+         +L+V  PP   A   
Sbjct: 1789 LGEEVFLLPGTHTLQLGRARLSDSGMYTCEA---LNAAGRDQKLVQLSVLVPP---AFRQ 1842

Query: 357  APAFLRGP-----------ARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAP 405
            AP   RGP           A L C   A P P  V W  D         G+ LV      
Sbjct: 1843 AP---RGPQDAVLVRVGDKAVLSCETDALPEP-TVTWYKD---------GQPLVLAQRTQ 1889

Query: 406  ESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 443
              RGG        L I   Q SD    ++C   N  GE
Sbjct: 1890 ALRGG------QRLEIQEAQVSD-KGLYSCKVSNVAGE 1920



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 57/230 (24%), Positives = 82/230 (35%), Gaps = 49/230 (21%)

Query: 201 TAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANR 252
           T +P VT   W KG S       P + V+ + S     VS        C+ +N VGS +R
Sbjct: 29  TPKPQVT---WRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSR 85

Query: 253 STALDVLFGPILQ--AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRR------------ 298
              L V   P ++   +   VS   G+  +  C   G P+P + W +             
Sbjct: 86  RAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAG 145

Query: 299 ----------GGAQVLGSGATLRLPSVGPEDAGDYVCRA----------EAGLSGLRGGA 338
                     GG ++L  G +L  P + P  +G    +A           AGL+G     
Sbjct: 146 YGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFP 205

Query: 339 AEARLTVNAPPVVTALHSAPAFL---RGPARLQCLVFASPAPDAVVWSWD 385
                +  APP V    +A   L        LQC     P P  V W+ D
Sbjct: 206 TPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQ-VEWTKD 254



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 44/130 (33%), Positives = 60/130 (46%), Gaps = 24/130 (18%)

Query: 271 VSVDVGEDASFSCAWRGNPLPRVTWTR---------RGGAQVLGSGATLRLPSVGPEDAG 321
           V++ VG +A   C   G P P+VTW +         + G  VL  G+ L L SV P D+G
Sbjct: 13  VALTVGLEAG-GCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGS-LFLASVSPADSG 70

Query: 322 DYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPA----RLQCLVFASP 375
           DY C+A  E G +  R     A+L V  PP +       A + G A     L+C     P
Sbjct: 71  DYECQATNEVGSTSRR-----AKLVVYVPPSIRE-DGRKANVSGMAGQSLTLECDANGFP 124

Query: 376 APDAVVWSWD 385
            P+ +VW  D
Sbjct: 125 VPE-IVWLKD 133


>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
           sapiens]
          Length = 790

 Score =  100 bits (250), Expect = 3e-21
 Identities = 94/326 (28%), Positives = 144/326 (44%), Gaps = 32/326 (9%)

Query: 33  NGQHDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVP 91
           +G     I      +E +YEC A ++AG     AQ+ V  PP  PQ++  P+V++  G  
Sbjct: 475 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP--PQLVPAPNVTVSPGET 532

Query: 92  ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 151
           A L+CR  G+A     L W RD  +L  +T     L        + +L ++     DG  
Sbjct: 533 AVLSCRVLGEA--PYNLTWVRDWRVLPASTGRVAQL-------ADLSLEISGIIPTDGGR 583

Query: 152 FVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRW 211
           + C A S A    R  ++ L ++  P+V++  S     +G +V   C A+  P      W
Sbjct: 584 YQCVA-SNANGVTR-ASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYP-TPHISW 640

Query: 212 AKGGSPVLGARGPRLEVVADASFLTEPV--------SCEVSNAVGSANRSTALDVLFGPI 263
           ++    +      R+ V A  + + + V        SC+ +N VG+   +  L     P 
Sbjct: 641 SRESQAL--QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 698

Query: 264 LQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVL----GSGATLRLPSVGPED 319
           + A    V V VGE+A   C   G P PRV W R G   +L     S   LR+P+    D
Sbjct: 699 VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERD 758

Query: 320 AGDYVCRAEAGLSGLRGGAAEARLTV 345
           AG Y CRA   ++ L   +AE +L V
Sbjct: 759 AGTYTCRA---VNELGDASAEIQLAV 781


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 109/353 (30%), Positives = 143/353 (40%), Gaps = 55/353 (15%)

Query: 38   LHIRPVELEDEASYECQATQA-GLRSRPAQLHVLVPP--EAPQV-LGGPSVSLVAGVPAN 93
            L IR V+L D  +Y C  +    +    A LHV       AP V +  P +++  G  A 
Sbjct: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAE 1884

Query: 94   LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 153
              C + G   PTP L W        G    Q   K    G +   L L      D A ++
Sbjct: 1885 FRCSATGS--PTPTLEW-------TGGPGGQLPAKAQIHGGI---LRLPAVEPTDQAQYL 1932

Query: 154  CRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 213
            CRA S A        + +     P V +S     V  G  V   C+A   P  T   W K
Sbjct: 1933 CRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSAT-ITWRK 1991

Query: 214  -GGSPVLGARGPRLEVV---------ADASFLTEPVSCEVSNAVGSANRSTALDVLFGPI 263
             GGS    AR  R ++          ADA F      C  ++  G+A     + VL    
Sbjct: 1992 EGGSLPPQARSERTDIATLLIPAITTADAGFYL----CVATSPAGTAQARIQVVVLSAS- 2046

Query: 264  LQAKPEPV-------SVDVGEDASFSCAWRGNPLPRVTWTRRGGA-----QVLGSGATLR 311
              A P PV       SV  G+    +C   G+   +VTW RRGG+     QV GS   LR
Sbjct: 2047 -DASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS--RLR 2103

Query: 312  LPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGP 364
            LP V P D+G+YVCR E G      G  EA +TV+   V+   HS P++   P
Sbjct: 2104 LPQVSPADSGEYVCRVENG-----SGPKEASITVS---VLHGTHSGPSYTPVP 2148



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 86/327 (26%), Positives = 124/327 (37%), Gaps = 29/327 (8%)

Query: 47   DEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPT 105
            +  +Y C A+ A G+      L V  PP    +  GP V +  G    L C S G+ R +
Sbjct: 3085 NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGP-VWVKVGKAVTLECVSAGEPRSS 3143

Query: 106  PELLWFRDGVLLDGATFHQTLLKEGTPGSVES--TLTLTPFSHDDGATFVCRARSQALPT 163
                W R        +     L++ T G ++S   L ++     D  T+VC A++ AL T
Sbjct: 3144 AR--WTR-------ISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQN-ALGT 3193

Query: 164  GR---DTAITLSLQYP--PEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPV 218
             +   +  +      P  P+V    +  TV+ G      C AT  P  T   W+K  SP+
Sbjct: 3194 AQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPT-IHWSKLRSPL 3252

Query: 219  LGAR---GPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDV 275
                   G  L +   A   +    C  ++  G A  +  L V   P     PE  SV  
Sbjct: 3253 PWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQA 3312

Query: 276  GEDASFSCAWRGNPLPRVTWTRRGGA---QVLGSGATLRLPSVGPEDAGDYVCRAEAGLS 332
            GE     C   G P     W+R G +   +       L      PED+G Y CR     +
Sbjct: 3313 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRV---TN 3369

Query: 333  GLRGGAAEARLTVNAPPVVTALHSAPA 359
             +    A A+L V  PP      S PA
Sbjct: 3370 KVGSAEAFAQLLVQGPPGSLPATSIPA 3396



 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 99/406 (24%), Positives = 158/406 (38%), Gaps = 72/406 (17%)

Query: 28   SGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEA----------PQ 77
            S +  +G H L +  + + D   Y C+A    + +  A + + V P A          P 
Sbjct: 2672 SRHQTHGSH-LRLHQMSVADSGEYVCRANN-NIDALEASIVISVSPSAGSPSAPGSSMPI 2729

Query: 78   VLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVES 137
             +   S  +  G   +L C   G A    ++ W + G  L   + HQT           S
Sbjct: 2730 RIESSSSHVAEGETLDLNCVVPGQAHA--QVTWHKRGGSLP--SHHQTR---------GS 2776

Query: 138  TLTLTPFSHDDGATFVCRARSQALPTGRDTAITL------SLQYP-----PEVTLSASPH 186
             L L   S  D   +VCR    + P      +T+      ++  P     P + +  S  
Sbjct: 2777 RLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSS 2836

Query: 187  TVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGAR----GPRLEVVADASFLTEPVSCE 242
             V EG+ +   C    Q         +GG+  L AR    GP L +   +   +   SC+
Sbjct: 2837 RVAEGQTLDLKCVVPGQAHAQVTWHKRGGN--LPARHQVHGPLLRLNQVSPADSGEYSCQ 2894

Query: 243  VSNAVGSANRSTALDV---LFGPI-LQAKPEPVSVDV-------GEDASFSCAWRGNPLP 291
            V+ + G+   S  + +     GPI      +P+ ++        G+    +C   G    
Sbjct: 2895 VTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHA 2954

Query: 292  RVTWTRRGG---AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAP 348
            +VTW +RGG   A+    G+ LRL  V P D+G+YVCRA +G     G   EA  TV  P
Sbjct: 2955 QVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASG----PGPEQEASFTVTVP 3010

Query: 349  -----------PVVTALHSAPAFLRG-PARLQCLVFASPAPDAVVW 382
                       PV++    +    +G  A  +CL+    AP ++ W
Sbjct: 3011 PSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEW 3056



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 94/327 (28%), Positives = 129/327 (39%), Gaps = 36/327 (11%)

Query: 22   WSRYWIS--GNAANGQHDLHIRPVELEDEASYECQAT-QAGLRSRPAQLHVLVPPEAPQV 78
            WSR   S  G A      LH      ED   Y C+ T + G     AQL V  PP +   
Sbjct: 3332 WSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSL-- 3389

Query: 79   LGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEG---TPGSV 135
               P+ S+ AG    +    + + +     + F   V  D  T      KEG    PG  
Sbjct: 3390 ---PATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGT-QLRWFKEGGQLPPGHS 3445

Query: 136  --ESTLTLTPFSHDDGATFVCRARSQALPTGRDTAIT-LSLQYPPEVTLS--ASPHTVQE 190
              +  L +         T++C+A     P G+  A   L +Q  P V ++   S  TV  
Sbjct: 3446 VQDGVLRIQNLDQSCQGTYICQAHG---PWGKAQASAQLVIQALPSVLINIRTSVQTVVV 3502

Query: 191  GEKVIFLCQATAQPPVTGYRWAKGGS---PVLGARGPRLEV----VADASFLTEPVSCEV 243
            G  V F C A   P      W+K G    P +   G  + +    +ADA        C  
Sbjct: 3503 GHAVEFECLALGDPKPQ-VTWSKVGGHLRPGIVQSGGVVRIAHVELADAG----QYRCTA 3557

Query: 244  SNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQV 303
            +NA G+      L V   P + + P+ V V  G  A F C   G P P ++W++  G+  
Sbjct: 3558 TNAAGTTQSHVLLLVQALPQI-SMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLP 3616

Query: 304  LGS---GATLRLPSVGPEDAGDYVCRA 327
              S      L LPSV P+DAG YVC A
Sbjct: 3617 PDSRLENNMLMLPSVRPQDAGTYVCTA 3643



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 98/372 (26%), Positives = 133/372 (35%), Gaps = 29/372 (7%)

Query: 38   LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L I  V  +D   Y C AT  AG       LHV  PP A  V    SV   AG    L C
Sbjct: 3263 LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQ--AGETVQLQC 3320

Query: 97   RSRGDARPTPELLWFRDGVLLDG-ATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 155
             + G   P     W R G  L G AT    LL        +S       ++  G+     
Sbjct: 3321 LAHGT--PPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFA 3378

Query: 156  ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGG 215
                  P G   A ++     P V ++    T   G  V F C A      T  RW K G
Sbjct: 3379 QLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHC-AVPSDRGTQLRWFKEG 3437

Query: 216  SPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGP--ILQ 265
              +     P    V D     + +         C+     G A  S  L +   P  ++ 
Sbjct: 3438 GQL-----PPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLIN 3492

Query: 266  AKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG---AQVLGSGATLRLPSVGPEDAGD 322
             +    +V VG    F C   G+P P+VTW++ GG     ++ SG  +R+  V   DAG 
Sbjct: 3493 IRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQ 3552

Query: 323  YVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVW 382
            Y C A       +   +   L V A P ++            A   C+    P PD + W
Sbjct: 3553 YRCTATNAAGTTQ---SHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPD-ISW 3608

Query: 383  SWDEGFLEAGSQ 394
            S  +G L   S+
Sbjct: 3609 SKLDGSLPPDSR 3620



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 95/366 (25%), Positives = 135/366 (36%), Gaps = 63/366 (17%)

Query: 54   QATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSL---VAGVPANLTCRSRGDARPTPELLW 110
            Q  Q    +  A L V V P    V  G S SL   V+G P +    SR D RP P    
Sbjct: 1664 QGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQ 1723

Query: 111  FRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARS--QALPTGRDTA 168
             R          HQ            S L        D   ++C  R+  Q+  +  +  
Sbjct: 1724 QR----------HQG-----------SELHFPSVQPSDAGVYICTCRNLHQSNTSRAELL 1762

Query: 169  ITLSLQYPPEVTLSAS-PHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP--- 224
            +T +   P  VT+      +V+ G  V F+C A ++ P     W +  +  L  R     
Sbjct: 1763 VTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFN 1822

Query: 225  -----RLEVVADASFLTEPVSCEVSNAVGSANRSTALDV-----LFGPILQAKPEPVSVD 274
                 R   ++DA        C  SN       +  L V     L  P++   P  ++V 
Sbjct: 1823 GILTIRNVQLSDAGTYV----CTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQ 1878

Query: 275  VGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS----GATLRLPSVGPEDAGDYVCRA--E 328
             G+ A F C+  G+P P + WT   G Q+       G  LRLP+V P D   Y+CRA   
Sbjct: 1879 PGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSS 1938

Query: 329  AGLSGLRG-----GAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWS 383
            AG    R      G    R+ V+  P  T +H+         RL C     P+   + W 
Sbjct: 1939 AGQQVARAVLHVHGGGGPRVQVS--PERTQVHAGRT-----VRLYCRAAGVPSA-TITWR 1990

Query: 384  WDEGFL 389
             + G L
Sbjct: 1991 KEGGSL 1996



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 101/366 (27%), Positives = 137/366 (37%), Gaps = 64/366 (17%)

Query: 38   LHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEA---PQVLGGPSVSLVAGVPAN 93
            L I  +   D   Y C AT  AG      Q+ VL   +A   P  +   S S+  G   +
Sbjct: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLD 2069

Query: 94   LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 153
            L C   G A    ++ W+R G  L   T               S L L   S  D   +V
Sbjct: 2070 LNCVVAGSAHA--QVTWYRRGGSLPPHTQVHG-----------SRLRLPQVSPADSGEYV 2116

Query: 154  CRARSQALPTGRDTAITLSL--------QYPP------EVTLSASPHTVQEGEKVIFLCQ 199
            CR  + + P  ++ +IT+S+         Y P       + +  S   V EG+ +   C 
Sbjct: 2117 CRVENGSGP--KEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCV 2174

Query: 200  ATAQPPVTGYRWAKGGSPVLGARGP------RLEVVADASFLTEPVSCEVSNAVGSANRS 253
               Q         +GGS  L AR        RL  V  A   +    C V    G    S
Sbjct: 2175 VPGQAHAQVTWHKRGGS--LPARHQTHGSLLRLHQVTPAD--SGEYVCHVVGTSGPLEAS 2230

Query: 254  TAL----DVLFGPILQAKPEPVSVDV--GEDASFSCAWRGNPLPRVTWTRRGGA-----Q 302
              +     V+ GPI   + E  S  V  G+    SC   G    +VTW +RGG+     Q
Sbjct: 2231 VLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQ 2290

Query: 303  VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 362
            V GS   L +    P DAG YVCRA  G+        EA +TV       A  + PA   
Sbjct: 2291 VRGS--RLYIFQASPADAGQYVCRASNGM--------EASITVTVTGTQGANLAYPAGST 2340

Query: 363  GPARLQ 368
             P R++
Sbjct: 2341 QPIRIE 2346



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 84/349 (24%), Positives = 129/349 (36%), Gaps = 76/349 (21%)

Query: 69   VLVPPEAPQVLGGPSVSLVAGVP----ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQ 124
            + + P + QV  G ++ L   VP    A +T   RG + P                    
Sbjct: 2343 IRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLP-------------------- 2382

Query: 125  TLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITL-------SLQYPP 177
              ++  T GS+   L L   S  D   +VCR    ++P      +T+       +L   P
Sbjct: 2383 --VRHQTHGSL---LRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTP 2437

Query: 178  EVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGAR----GPRLEVVADAS 233
             V + +S   V EG+ +   C    Q         +GGS  L AR    G RL ++    
Sbjct: 2438 TVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGS--LPARHQVHGSRLRLLQVTP 2495

Query: 234  FLTEPVSCEVSNAVGSANRSTALDV---LFGPILQAKPEPVSVDV-------GEDASFSC 283
              +    C V  + G+   S  + +   L G   Q    PV ++        G     +C
Sbjct: 2496 ADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNC 2555

Query: 284  AWRGNPLPRVTWTRRGGA-----QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGA 338
                     +TW +RGG+     Q++GS   LR+P V P D+G+YVC    G      G+
Sbjct: 2556 LVASQAPHTITWYKRGGSLPSRHQIVGS--RLRIPQVTPADSGEYVCHVSNG-----AGS 2608

Query: 339  AEARLTV-----------NAPPVVTALHSAPAFLRGPA-RLQCLVFASP 375
             E  L V           +  P +    S+P  + G    L C+V   P
Sbjct: 2609 RETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQP 2657



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 71/284 (25%), Positives = 111/284 (39%), Gaps = 44/284 (15%)

Query: 76   PQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSV 135
            P  +   S SL  G   +L C     A  T  + W++ G  L     HQ          V
Sbjct: 2535 PVRIESSSASLANGHTLDLNCLVASQAPHT--ITWYKRGGSLPSR--HQI---------V 2581

Query: 136  ESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQ---------YPPEVTLSASPH 186
             S L +   +  D   +VC   + A    R+T++ +++Q           P + + +S  
Sbjct: 2582 GSRLRIPQVTPADSGEYVCHVSNGA--GSRETSLIVTIQGSGSSHVPSVSPPIRIESSSP 2639

Query: 187  TVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGAR----GPRLEVVADASFLTEPVSCE 242
            TV EG+ +   C    QP      + +GGS  L +R    G  L +   +   +    C 
Sbjct: 2640 TVVEGQTLDLNCVVARQPQAIITWYKRGGS--LPSRHQTHGSHLRLHQMSVADSGEYVCR 2697

Query: 243  VSNAVGSANRSTALDV---LFGPILQAKPEPVSVD-------VGEDASFSCAWRGNPLPR 292
             +N + +   S  + V      P       P+ ++        GE    +C   G    +
Sbjct: 2698 ANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQ 2757

Query: 293  VTWTRRGG---AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSG 333
            VTW +RGG   +     G+ LRL  V P D+G+YVCR   G SG
Sbjct: 2758 VTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRV-MGSSG 2800



 Score = 30.0 bits (66), Expect = 6.1
 Identities = 22/99 (22%), Positives = 32/99 (32%), Gaps = 9/99 (9%)

Query: 238 PVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTR 297
           P S          +RS     +   ++    E +    G+  +F+C   G P P + W  
Sbjct: 383 PASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRL 442

Query: 298 RGG---------AQVLGSGATLRLPSVGPEDAGDYVCRA 327
             G             G   TL +  V   D G Y C A
Sbjct: 443 NWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEA 481


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 108/402 (26%), Positives = 158/402 (39%), Gaps = 41/402 (10%)

Query: 76  PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 130
           P+++  PS  +V+ G PA L C++ G  RPTP + W++ G  +    D    H+ LL  G
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEG--RPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 131 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYP---PEVTLSASPHT 187
           +   +   +     S  D   +VC AR+     G   +   SL+      +   + S   
Sbjct: 87  SLFFLR--IVHGRKSRPDEGVYVCVARNY---LGEAVSHNASLEVAILRDDFRQNPSDVM 141

Query: 188 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTEPVSC 241
           V  GE  +  CQ     P     W K GSP+      +  RG +L +            C
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201

Query: 242 EVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 300
             +N VG      A L VL  P    +P  ++V V + A F C  RG+P+P V W +  G
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261

Query: 301 -----AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP-VVTAL 354
                   +    TL++  V   D G Y C AE   + +    A A LTV  PP  V   
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAE---NMVGKAEASATLTVQEPPHFVVKP 318

Query: 355 HSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPG 414
                 L      QC    +P P A+ W         GSQ   L+ ++  P+S       
Sbjct: 319 RDQVVALGRTVTFQCEATGNPQP-AIFWR------REGSQN--LLFSYQPPQSSSRFSVS 369

Query: 415 LISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL 456
               L I+  Q SD    + C   N  G    +A L   D++
Sbjct: 370 QTGDLTITNVQRSDVG-YYICQTLNVAGSIITKAYLEVTDVI 410



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 82/331 (24%), Positives = 116/331 (35%), Gaps = 47/331 (14%)

Query: 84  VSLVAGVPANLTCRS-RGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLT 142
           V +  G PA + C+  RG   P P + W +DG  LD      T+            L +T
Sbjct: 140 VMVAVGEPAVMECQPPRG--HPEPTISWKKDGSPLDDKDERITIRG--------GKLMIT 189

Query: 143 PFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATA 202
                D   +VC   +       + A    L+ P  V    S   V   +   F C+A  
Sbjct: 190 YTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK-RPSNLAVTVDDSAEFKCEARG 248

Query: 203 QPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRST 254
            P  T  RW K    +  +R    E+  D +     V+        C   N VG A  S 
Sbjct: 249 DPVPT-VRWRKDDGELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304

Query: 255 ALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS-------- 306
            L V   P    KP    V +G   +F C   GNP P + W R G   +L S        
Sbjct: 305 TLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 364

Query: 307 ------GATLRLPSVGPEDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAP 358
                    L + +V   D G Y+C+    AG    +       +  + PP V  +   P
Sbjct: 365 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV--IRQGP 422

Query: 359 ----AFLRGPARLQCLVFASPAPDAVVWSWD 385
                 + G   L C+   SP P  ++W  D
Sbjct: 423 VNQTVAVDGTFVLSCVATGSPVP-TILWRKD 452



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 74/301 (24%), Positives = 109/301 (36%), Gaps = 46/301 (15%)

Query: 175 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 230
           +PP +    S   V +GE     C+A  +P  T   W KGG  V       R  R+ + +
Sbjct: 27  FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDPRSHRMLLPS 85

Query: 231 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 276
            + F    V             C   N +G A + + +L+V +     +  P  V V VG
Sbjct: 86  GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145

Query: 277 EDASFSC-AWRGNPLPRVTWTRRGG------AQVLGSGATLRLPSVGPEDAGDYVCRAEA 329
           E A   C   RG+P P ++W + G        ++   G  L +      DAG YVC    
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-VGT 204

Query: 330 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFL 389
            + G R         +  P  V    +    +   A  +C     P P  V W  D+G L
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-TVRWRKDDGEL 263

Query: 390 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQAS 449
                          P+SR  +       L I      D   S+ C A N +G+  A A+
Sbjct: 264 ---------------PKSRYEIRDD--HTLKIRKVTAGDMG-SYTCVAENMVGKAEASAT 305

Query: 450 L 450
           L
Sbjct: 306 L 306



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 86/387 (22%), Positives = 138/387 (35%), Gaps = 52/387 (13%)

Query: 47  DEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPANLTCRSRGDARPT 105
           D   Y C  T   +  R +++  L   E P  +  PS +++     A   C +RGD  P 
Sbjct: 195 DAGKYVCVGTNM-VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD--PV 251

Query: 106 PELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR 165
           P + W +D    DG      L K       + TL +   +  D  ++ C A +       
Sbjct: 252 PTVRWRKD----DGE-----LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA-- 300

Query: 166 DTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP- 224
           + + TL++Q PP   +      V  G  V F C+AT  P    +   +G   +L +  P 
Sbjct: 301 EASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 360

Query: 225 ----RLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPILQAKPEPV- 271
               R  V          V         C+  N  GS      L+V    ++  +P PV 
Sbjct: 361 QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT--DVIADRPPPVI 418

Query: 272 -----SVDVGEDASF--SCAWRGNPLPRVTWTRRGG---------AQVLGSGATLRLPSV 315
                +  V  D +F  SC   G+P+P + W + G           Q+      +R   +
Sbjct: 419 RQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKL 478

Query: 316 GPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASP 375
           G  D G Y C A    SG    +A   +     PV     + P  +  P+          
Sbjct: 479 G--DTGRYTCIASTP-SGEATWSAYIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVTDV 533

Query: 376 APDAVVWSWDEGFLEAGSQGRFLVETF 402
           + + V  SW        +   +++E F
Sbjct: 534 SRNTVTLSWQPNLNSGATPTSYIIEAF 560



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 50/188 (26%), Positives = 68/188 (36%), Gaps = 16/188 (8%)

Query: 36  HDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVA-GVPAN 93
           H L IR V   D  SY C A    G     A L V    E P  +  P   +VA G    
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV---QEPPHFVVKPRDQVVALGRTVT 330

Query: 94  LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST--LTLTPFSHDDGAT 151
             C + G+  P P + W R+G       F     +  +  SV  T  LT+T     D   
Sbjct: 331 FQCEATGN--PQPAIFWRREG--SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 386

Query: 152 FVCR----ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT 207
           ++C+    A S       +    ++ + PP +       TV      +  C AT   PV 
Sbjct: 387 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS-PVP 445

Query: 208 GYRWAKGG 215
              W K G
Sbjct: 446 TILWRKDG 453


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 108/402 (26%), Positives = 158/402 (39%), Gaps = 41/402 (10%)

Query: 76  PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 130
           P+++  PS  +V+ G PA L C++ G  RPTP + W++ G  +    D    H+ LL  G
Sbjct: 68  PRIVEHPSDLIVSKGEPATLNCKAEG--RPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125

Query: 131 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYP---PEVTLSASPHT 187
           +   +   +     S  D   +VC AR+     G   +   SL+      +   + S   
Sbjct: 126 SLFFLR--IVHGRKSRPDEGVYVCVARNY---LGEAVSHNASLEVAILRDDFRQNPSDVM 180

Query: 188 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTEPVSC 241
           V  GE  +  CQ     P     W K GSP+      +  RG +L +            C
Sbjct: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 240

Query: 242 EVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 300
             +N VG      A L VL  P    +P  ++V V + A F C  RG+P+P V W +  G
Sbjct: 241 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 300

Query: 301 -----AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP-VVTAL 354
                   +    TL++  V   D G Y C AE   + +    A A LTV  PP  V   
Sbjct: 301 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAE---NMVGKAEASATLTVQEPPHFVVKP 357

Query: 355 HSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPG 414
                 L      QC    +P P A+ W         GSQ   L+ ++  P+S       
Sbjct: 358 RDQVVALGRTVTFQCEATGNPQP-AIFWR------REGSQN--LLFSYQPPQSSSRFSVS 408

Query: 415 LISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL 456
               L I+  Q SD    + C   N  G    +A L   D++
Sbjct: 409 QTGDLTITNVQRSDVG-YYICQTLNVAGSIITKAYLEVTDVI 449



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 82/331 (24%), Positives = 116/331 (35%), Gaps = 47/331 (14%)

Query: 84  VSLVAGVPANLTCRS-RGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLT 142
           V +  G PA + C+  RG   P P + W +DG  LD      T+            L +T
Sbjct: 179 VMVAVGEPAVMECQPPRG--HPEPTISWKKDGSPLDDKDERITIRG--------GKLMIT 228

Query: 143 PFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATA 202
                D   +VC   +       + A    L+ P  V    S   V   +   F C+A  
Sbjct: 229 YTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK-RPSNLAVTVDDSAEFKCEARG 287

Query: 203 QPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRST 254
            P  T  RW K    +  +R    E+  D +     V+        C   N VG A  S 
Sbjct: 288 DPVPT-VRWRKDDGELPKSR---YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 343

Query: 255 ALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGS-------- 306
            L V   P    KP    V +G   +F C   GNP P + W R G   +L S        
Sbjct: 344 TLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 403

Query: 307 ------GATLRLPSVGPEDAGDYVCRA--EAGLSGLRGGAAEARLTVNAPPVVTALHSAP 358
                    L + +V   D G Y+C+    AG    +       +  + PP V  +   P
Sbjct: 404 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV--IRQGP 461

Query: 359 ----AFLRGPARLQCLVFASPAPDAVVWSWD 385
                 + G   L C+   SP P  ++W  D
Sbjct: 462 VNQTVAVDGTFVLSCVATGSPVP-TILWRKD 491



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 74/301 (24%), Positives = 109/301 (36%), Gaps = 46/301 (15%)

Query: 175 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 230
           +PP +    S   V +GE     C+A  +P  T   W KGG  V       R  R+ + +
Sbjct: 66  FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDPRSHRMLLPS 124

Query: 231 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 276
            + F    V             C   N +G A + + +L+V +     +  P  V V VG
Sbjct: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 184

Query: 277 EDASFSC-AWRGNPLPRVTWTRRGG------AQVLGSGATLRLPSVGPEDAGDYVCRAEA 329
           E A   C   RG+P P ++W + G        ++   G  L +      DAG YVC    
Sbjct: 185 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-VGT 243

Query: 330 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFL 389
            + G R         +  P  V    +    +   A  +C     P P  V W  D+G L
Sbjct: 244 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-TVRWRKDDGEL 302

Query: 390 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQAS 449
                          P+SR  +       L I      D   S+ C A N +G+  A A+
Sbjct: 303 ---------------PKSRYEIRDD--HTLKIRKVTAGDMG-SYTCVAENMVGKAEASAT 344

Query: 450 L 450
           L
Sbjct: 345 L 345



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 86/387 (22%), Positives = 138/387 (35%), Gaps = 52/387 (13%)

Query: 47  DEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPANLTCRSRGDARPT 105
           D   Y C  T   +  R +++  L   E P  +  PS +++     A   C +RGD  P 
Sbjct: 234 DAGKYVCVGTNM-VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD--PV 290

Query: 106 PELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR 165
           P + W +D    DG      L K       + TL +   +  D  ++ C A +       
Sbjct: 291 PTVRWRKD----DGE-----LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA-- 339

Query: 166 DTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP- 224
           + + TL++Q PP   +      V  G  V F C+AT  P    +   +G   +L +  P 
Sbjct: 340 EASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 399

Query: 225 ----RLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPILQAKPEPV- 271
               R  V          V         C+  N  GS      L+V    ++  +P PV 
Sbjct: 400 QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT--DVIADRPPPVI 457

Query: 272 -----SVDVGEDASF--SCAWRGNPLPRVTWTRRGG---------AQVLGSGATLRLPSV 315
                +  V  D +F  SC   G+P+P + W + G           Q+      +R   +
Sbjct: 458 RQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKL 517

Query: 316 GPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASP 375
           G  D G Y C A    SG    +A   +     PV     + P  +  P+          
Sbjct: 518 G--DTGRYTCIASTP-SGEATWSAYIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVTDV 572

Query: 376 APDAVVWSWDEGFLEAGSQGRFLVETF 402
           + + V  SW        +   +++E F
Sbjct: 573 SRNTVTLSWQPNLNSGATPTSYIIEAF 599



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 50/188 (26%), Positives = 68/188 (36%), Gaps = 16/188 (8%)

Query: 36  HDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVA-GVPAN 93
           H L IR V   D  SY C A    G     A L V    E P  +  P   +VA G    
Sbjct: 313 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV---QEPPHFVVKPRDQVVALGRTVT 369

Query: 94  LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST--LTLTPFSHDDGAT 151
             C + G+  P P + W R+G       F     +  +  SV  T  LT+T     D   
Sbjct: 370 FQCEATGN--PQPAIFWRREG--SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 425

Query: 152 FVCR----ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT 207
           ++C+    A S       +    ++ + PP +       TV      +  C AT   PV 
Sbjct: 426 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS-PVP 484

Query: 208 GYRWAKGG 215
              W K G
Sbjct: 485 TILWRKDG 492


>gi|4758822 nephrin precursor [Homo sapiens]
          Length = 1241

 Score = 95.9 bits (237), Expect = 9e-20
 Identities = 90/301 (29%), Positives = 131/301 (43%), Gaps = 37/301 (12%)

Query: 21  GWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQA----GLRSRPAQLHVLVPPE-- 74
           G+ RY + G+ A G+  LHI   +L D+A YECQ  ++     L S    L +LVPP+  
Sbjct: 79  GFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLL 138

Query: 75  --APQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFH--QTLLKEG 130
              P+   G  V+ VAG    + C S GDA+P P++      +LL G T       + EG
Sbjct: 139 LLTPE--AGTMVTWVAGQEYVVNCVS-GDAKPAPDIT-----ILLSGQTISDISANVNEG 190

Query: 131 TPG---SVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 187
           +     +VE+T  +TP S D+    VC A S AL      + T+++ +PP   +   P  
Sbjct: 191 SQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGL 250

Query: 188 ----VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPV---- 239
               V+ G+ +   C A    P+   +W K G PV  A G         S L   V    
Sbjct: 251 DEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPED 310

Query: 240 -----SCEVSNAV--GSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPR 292
                SCE  N+V  G+      L V F P         S    ++ + SC  + +  PR
Sbjct: 311 HGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSS-RPR 369

Query: 293 V 293
           V
Sbjct: 370 V 370



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 110/430 (25%), Positives = 172/430 (40%), Gaps = 56/430 (13%)

Query: 46  EDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPT 105
           +++A + C+A Q    S   QL V  PP    +L   S +L  G   NLTC S   + P 
Sbjct: 521 DNQAKFTCKAGQL---SASTQLAVQFPPTNVTILANAS-ALRPGDALNLTCVSVS-SNPP 575

Query: 106 PELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR 165
             L W ++G  L+G              +  S L L   S D G    CRA S  L    
Sbjct: 576 VNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVL-LQVSSRDHGQRVTCRAHSAELRETV 634

Query: 166 DTAITLSLQYPPE------VTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL 219
            +   L++ Y PE      + ++A    V++GE ++ +   +A P    + W   G  + 
Sbjct: 635 SSFYRLNVLYRPEFLGEQVLVVTA----VEQGEALLPV-SVSANPAPEAFNWTFRGYRLS 689

Query: 220 GARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPILQAKPEPV 271
            A GPR  +++  +     V+            N+ G+A     LDV + P ++A  +P 
Sbjct: 690 PAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPT 749

Query: 272 SVDVGEDASFSCAWRGNP-LPRV-TWTRRG---------GAQVLGSGAT--LRLPSVGPE 318
            V+VG      C    NP LP +  W R G           + +  G T  LR+      
Sbjct: 750 EVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLA 809

Query: 319 DAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV---TALH--SAPAFLRGPARLQCLVFA 373
            AG Y C  + G++         RL V   P V   T L   +A       A L C    
Sbjct: 810 QAGAYQCIVDNGVA--PPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARG 867

Query: 374 SPAPDAVVWSWDEGFLEAGSQG-RFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRS 432
            P    +V++W +  +    Q  R+   T+     +GG+   L+++ ++S  Q+      
Sbjct: 868 VP---NIVFTWTKNGVPLDLQDPRYTEHTY----HQGGVHSSLLTIANVSAAQDYAL--- 917

Query: 433 FNCSARNRLG 442
           F C+A N LG
Sbjct: 918 FTCTATNALG 927



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 98/396 (24%), Positives = 151/396 (38%), Gaps = 66/396 (16%)

Query: 40  IRPVELEDEASYECQATQAGLRS---RPAQLHVLVPPEAPQVLGGPSVS---LVAGVPAN 93
           + P   ++     C+A+   L +       ++VL PP  P V+  P +    + AG    
Sbjct: 204 VTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPP-GPPVIEWPGLDEGHVRAGQSLE 262

Query: 94  LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 153
           L C +RG   P   L W ++G  +  A        E T     S L +T    D GA   
Sbjct: 263 LPCVARG-GNPLATLQWLKNGQPVSTAWG-----TEHTQAVARSVLVMTVRPEDHGAQLS 316

Query: 154 CRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAK 213
           C A +      ++  ITL + +PP   +     +  E + V   C + +  P    RW  
Sbjct: 317 CEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWL 376

Query: 214 GGSPVL--------GARGPRLEVVADASFLTE------PVSCEVSNAV---GSANRSTAL 256
           G   +L        G  G  +  +++ +FL         ++CE  +      +  +S  L
Sbjct: 377 GWRQLLPMEETVMDGLHGGHIS-MSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLIL 435

Query: 257 DVLFGP---ILQAKPEPVSVDVGEDASFSC-AWRGNPLPRVTW---------------TR 297
           +V +      ++  PE   +  G      C A  GNP P + W               +R
Sbjct: 436 NVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESR 495

Query: 298 R---GGAQVLGSGATLRLPSV-GPED-AGDYVCRAEAGLSGLRGGAAEARLTVNAPPV-V 351
           R   G  +  GS  +  L  V GP D    + C+A   LS      A  +L V  PP  V
Sbjct: 496 RVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA-GQLS------ASTQLAVQFPPTNV 548

Query: 352 TALHSAPAFLRGPA-RLQCLVFASPAPDAVVWSWDE 386
           T L +A A   G A  L C+  +S  P  V  SWD+
Sbjct: 549 TILANASALRPGDALNLTCVSVSSNPP--VNLSWDK 582


>gi|21686977 cell adhesion molecule 4 [Homo sapiens]
          Length = 388

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 74/236 (31%), Positives = 102/236 (43%), Gaps = 24/236 (10%)

Query: 38  LHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAP------QVLGGPSVSLVAGVP 91
           + +    LEDE  Y CQ        + A L VLV PE P      Q + G  V L   VP
Sbjct: 89  IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVP 148

Query: 92  ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 151
            +         RP   L W+RD   L G +  Q   + G   SV ST+       DDG  
Sbjct: 149 RS---------RPAATLRWYRDRKELKGVSSSQ---ENGKVWSVASTVRFRVDRKDDGGI 196

Query: 152 FVCRARSQALPTG--RDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGY 209
            +C A++QALP+G  + T   L +QY P   + AS   V+EG+ ++  C  T  P     
Sbjct: 197 IICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQI 256

Query: 210 RWAKGGSPV---LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGP 262
           RW +G   +     A G  L +    S      +CE SN  G A R+  + V++ P
Sbjct: 257 RWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHA-RALYVLVVYDP 311



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 81/328 (24%), Positives = 118/328 (35%), Gaps = 41/328 (12%)

Query: 73  PEAPQVLGGPSVSLVAGVPANLTCRSRGD-------ARPTPELLWFRDGVLLDGATFHQT 125
           P A Q +   +V++  G  A +TCR             P  + L+F     L    F   
Sbjct: 21  PGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQ-- 78

Query: 126 LLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASP 185
            L+E +P  V   + L+    +D   + C+  ++   T    A TL++   PE  +    
Sbjct: 79  -LEEFSPRRVR--IRLSDARLEDEGGYFCQLYTE--DTHHQIA-TLTVLVAPENPVVEVR 132

Query: 186 HTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGA-----RGPRLEVVADASFLTEP-- 238
               EG +V   C      P    RW +    + G       G    V +   F  +   
Sbjct: 133 EQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKD 192

Query: 239 ----VSCEVSNAVGSANRST----ALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPL 290
               + CE  N    +  S      LDV + P  +       V  G+    +CA  GNP 
Sbjct: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPR 252

Query: 291 P-RVTWTRRGGA---QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVN 346
           P ++ W R   +   +    G TL LP +   D G Y C A    S   G A    + V 
Sbjct: 253 PNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEA----SNKHGHARALYVLVV 308

Query: 347 APP--VVTALHSAPAFLRGPARLQCLVF 372
             P  VV A  S P  + G   L  LVF
Sbjct: 309 YDPGAVVEAQTSVPYAIVG-GILALLVF 335


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 107/407 (26%), Positives = 157/407 (38%), Gaps = 48/407 (11%)

Query: 76  PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 130
           P+++  PS  +V+ G PA L C++ G  RPTP + W++ G  +    D    H+ LL  G
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEG--RPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 131 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYP---PEVTLSASPHT 187
           +   +   +     S  D   +VC AR+     G   +   SL+      +   + S   
Sbjct: 87  SLFFLR--IVHGRKSRPDEGVYVCVARNYL---GEAVSHNASLEVAILRDDFRQNPSDVM 141

Query: 188 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTEPVSC 241
           V  GE  +  CQ     P     W K GSP+      +  RG +L +            C
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201

Query: 242 EVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 300
             +N VG      A L VL  P    +P  ++V V + A F C  RG+P+P V W +  G
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261

Query: 301 -----AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA------PP 349
                   +    TL++  V   D G Y C AE  +     G AEA  T+        P 
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV-----GKAEASATLTVQVGSEPPH 316

Query: 350 VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRG 409
            V         L      QC    +P P A+ W         GSQ   L+ ++  P+S  
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWR------REGSQN--LLFSYQPPQSSS 367

Query: 410 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL 456
                    L I+  Q SD    + C   N  G    +A L   D++
Sbjct: 368 RFSVSQTGDLTITNVQRSDVG-YYICQTLNVAGSIITKAYLEVTDVI 413



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 74/301 (24%), Positives = 109/301 (36%), Gaps = 46/301 (15%)

Query: 175 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 230
           +PP +    S   V +GE     C+A  +P  T   W KGG  V       R  R+ + +
Sbjct: 27  FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDPRSHRMLLPS 85

Query: 231 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 276
            + F    V             C   N +G A + + +L+V +     +  P  V V VG
Sbjct: 86  GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145

Query: 277 EDASFSC-AWRGNPLPRVTWTRRGG------AQVLGSGATLRLPSVGPEDAGDYVCRAEA 329
           E A   C   RG+P P ++W + G        ++   G  L +      DAG YVC    
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-VGT 204

Query: 330 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFL 389
            + G R         +  P  V    +    +   A  +C     P P  V W  D+G L
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-TVRWRKDDGEL 263

Query: 390 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQAS 449
                          P+SR  +       L I      D   S+ C A N +G+  A A+
Sbjct: 264 ---------------PKSRYEIRDD--HTLKIRKVTAGDMG-SYTCVAENMVGKAEASAT 305

Query: 450 L 450
           L
Sbjct: 306 L 306



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 84/388 (21%), Positives = 135/388 (34%), Gaps = 51/388 (13%)

Query: 47  DEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPANLTCRSRGDARPT 105
           D   Y C  T   +  R +++  L   E P  +  PS +++     A   C +RGD  P 
Sbjct: 195 DAGKYVCVGTNM-VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD--PV 251

Query: 106 PELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR 165
           P + W +D    DG      L K       + TL +   +  D  ++ C A +       
Sbjct: 252 PTVRWRKD----DGE-----LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA 302

Query: 166 DTAITLSL-QYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP 224
              +T+ +   PP   +      V  G  V F C+AT  P    +   +G   +L +  P
Sbjct: 303 SATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 362

Query: 225 -----RLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPILQAKPEPV 271
                R  V          V         C+  N  GS      L+V    ++  +P PV
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT--DVIADRPPPV 420

Query: 272 ------SVDVGEDASF--SCAWRGNPLPRVTWTRRGG---------AQVLGSGATLRLPS 314
                 +  V  D +F  SC   G+P+P + W + G           Q+      +R   
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 315 VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFAS 374
           +G  D G Y C A    SG    +A   +     PV     + P  +  P+         
Sbjct: 481 LG--DTGRYTCIASTP-SGEATWSAYIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVTD 535

Query: 375 PAPDAVVWSWDEGFLEAGSQGRFLVETF 402
            + + V  SW        +   +++E F
Sbjct: 536 VSRNTVTLSWQPNLNSGATPTSYIIEAF 563



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 51/188 (27%), Positives = 69/188 (36%), Gaps = 13/188 (6%)

Query: 36  HDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVA-GVPAN 93
           H L IR V   D  SY C A    G     A L V V  E P  +  P   +VA G    
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333

Query: 94  LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST--LTLTPFSHDDGAT 151
             C + G+  P P + W R+G       F     +  +  SV  T  LT+T     D   
Sbjct: 334 FQCEATGN--PQPAIFWRREG--SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389

Query: 152 FVCR----ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT 207
           ++C+    A S       +    ++ + PP +       TV      +  C AT   PV 
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS-PVP 448

Query: 208 GYRWAKGG 215
              W K G
Sbjct: 449 TILWRKDG 456


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 107/407 (26%), Positives = 157/407 (38%), Gaps = 48/407 (11%)

Query: 76  PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 130
           P+++  PS  +V+ G PA L C++ G  RPTP + W++ G  +    D    H+ LL  G
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEG--RPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 131 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYP---PEVTLSASPHT 187
           +   +   +     S  D   +VC AR+     G   +   SL+      +   + S   
Sbjct: 87  SLFFLR--IVHGRKSRPDEGVYVCVARNYL---GEAVSHNASLEVAILRDDFRQNPSDVM 141

Query: 188 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTEPVSC 241
           V  GE  +  CQ     P     W K GSP+      +  RG +L +            C
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201

Query: 242 EVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 300
             +N VG      A L VL  P    +P  ++V V + A F C  RG+P+P V W +  G
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261

Query: 301 -----AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA------PP 349
                   +    TL++  V   D G Y C AE  +     G AEA  T+        P 
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV-----GKAEASATLTVQVGSEPPH 316

Query: 350 VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRG 409
            V         L      QC    +P P A+ W         GSQ   L+ ++  P+S  
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWR------REGSQN--LLFSYQPPQSSS 367

Query: 410 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL 456
                    L I+  Q SD    + C   N  G    +A L   D++
Sbjct: 368 RFSVSQTGDLTITNVQRSDVG-YYICQTLNVAGSIITKAYLEVTDVI 413



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 74/301 (24%), Positives = 109/301 (36%), Gaps = 46/301 (15%)

Query: 175 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 230
           +PP +    S   V +GE     C+A  +P  T   W KGG  V       R  R+ + +
Sbjct: 27  FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDPRSHRMLLPS 85

Query: 231 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 276
            + F    V             C   N +G A + + +L+V +     +  P  V V VG
Sbjct: 86  GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145

Query: 277 EDASFSC-AWRGNPLPRVTWTRRGG------AQVLGSGATLRLPSVGPEDAGDYVCRAEA 329
           E A   C   RG+P P ++W + G        ++   G  L +      DAG YVC    
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-VGT 204

Query: 330 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFL 389
            + G R         +  P  V    +    +   A  +C     P P  V W  D+G L
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-TVRWRKDDGEL 263

Query: 390 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQAS 449
                          P+SR  +       L I      D   S+ C A N +G+  A A+
Sbjct: 264 ---------------PKSRYEIRDD--HTLKIRKVTAGDMG-SYTCVAENMVGKAEASAT 305

Query: 450 L 450
           L
Sbjct: 306 L 306



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 84/388 (21%), Positives = 135/388 (34%), Gaps = 51/388 (13%)

Query: 47  DEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPANLTCRSRGDARPT 105
           D   Y C  T   +  R +++  L   E P  +  PS +++     A   C +RGD  P 
Sbjct: 195 DAGKYVCVGTNM-VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD--PV 251

Query: 106 PELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR 165
           P + W +D    DG      L K       + TL +   +  D  ++ C A +       
Sbjct: 252 PTVRWRKD----DGE-----LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA 302

Query: 166 DTAITLSL-QYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP 224
              +T+ +   PP   +      V  G  V F C+AT  P    +   +G   +L +  P
Sbjct: 303 SATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 362

Query: 225 -----RLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPILQAKPEPV 271
                R  V          V         C+  N  GS      L+V    ++  +P PV
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT--DVIADRPPPV 420

Query: 272 ------SVDVGEDASF--SCAWRGNPLPRVTWTRRGG---------AQVLGSGATLRLPS 314
                 +  V  D +F  SC   G+P+P + W + G           Q+      +R   
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 315 VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFAS 374
           +G  D G Y C A    SG    +A   +     PV     + P  +  P+         
Sbjct: 481 LG--DTGRYTCIASTP-SGEATWSAYIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVTD 535

Query: 375 PAPDAVVWSWDEGFLEAGSQGRFLVETF 402
            + + V  SW        +   +++E F
Sbjct: 536 VSRNTVTLSWQPNLNSGATPTSYIIEAF 563



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 51/188 (27%), Positives = 69/188 (36%), Gaps = 13/188 (6%)

Query: 36  HDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVA-GVPAN 93
           H L IR V   D  SY C A    G     A L V V  E P  +  P   +VA G    
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333

Query: 94  LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST--LTLTPFSHDDGAT 151
             C + G+  P P + W R+G       F     +  +  SV  T  LT+T     D   
Sbjct: 334 FQCEATGN--PQPAIFWRREG--SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389

Query: 152 FVCR----ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT 207
           ++C+    A S       +    ++ + PP +       TV      +  C AT   PV 
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS-PVP 448

Query: 208 GYRWAKGG 215
              W K G
Sbjct: 449 TILWRKDG 456


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 107/407 (26%), Positives = 157/407 (38%), Gaps = 48/407 (11%)

Query: 76  PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 130
           P+++  PS  +V+ G PA L C++ G  RPTP + W++ G  +    D    H+ LL  G
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEG--RPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 131 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYP---PEVTLSASPHT 187
           +   +   +     S  D   +VC AR+     G   +   SL+      +   + S   
Sbjct: 87  SLFFLR--IVHGRKSRPDEGVYVCVARNYL---GEAVSHNASLEVAILRDDFRQNPSDVM 141

Query: 188 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTEPVSC 241
           V  GE  +  CQ     P     W K GSP+      +  RG +L +            C
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201

Query: 242 EVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 300
             +N VG      A L VL  P    +P  ++V V + A F C  RG+P+P V W +  G
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261

Query: 301 -----AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA------PP 349
                   +    TL++  V   D G Y C AE  +     G AEA  T+        P 
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV-----GKAEASATLTVQVGSEPPH 316

Query: 350 VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRG 409
            V         L      QC    +P P A+ W         GSQ   L+ ++  P+S  
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWR------REGSQN--LLFSYQPPQSSS 367

Query: 410 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL 456
                    L I+  Q SD    + C   N  G    +A L   D++
Sbjct: 368 RFSVSQTGDLTITNVQRSDVG-YYICQTLNVAGSIITKAYLEVTDVI 413



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 74/301 (24%), Positives = 109/301 (36%), Gaps = 46/301 (15%)

Query: 175 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 230
           +PP +    S   V +GE     C+A  +P  T   W KGG  V       R  R+ + +
Sbjct: 27  FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDPRSHRMLLPS 85

Query: 231 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 276
            + F    V             C   N +G A + + +L+V +     +  P  V V VG
Sbjct: 86  GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145

Query: 277 EDASFSC-AWRGNPLPRVTWTRRGG------AQVLGSGATLRLPSVGPEDAGDYVCRAEA 329
           E A   C   RG+P P ++W + G        ++   G  L +      DAG YVC    
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-VGT 204

Query: 330 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFL 389
            + G R         +  P  V    +    +   A  +C     P P  V W  D+G L
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-TVRWRKDDGEL 263

Query: 390 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQAS 449
                          P+SR  +       L I      D   S+ C A N +G+  A A+
Sbjct: 264 ---------------PKSRYEIRDD--HTLKIRKVTAGDMG-SYTCVAENMVGKAEASAT 305

Query: 450 L 450
           L
Sbjct: 306 L 306



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 84/388 (21%), Positives = 135/388 (34%), Gaps = 51/388 (13%)

Query: 47  DEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPANLTCRSRGDARPT 105
           D   Y C  T   +  R +++  L   E P  +  PS +++     A   C +RGD  P 
Sbjct: 195 DAGKYVCVGTNM-VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD--PV 251

Query: 106 PELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR 165
           P + W +D    DG      L K       + TL +   +  D  ++ C A +       
Sbjct: 252 PTVRWRKD----DGE-----LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA 302

Query: 166 DTAITLSL-QYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP 224
              +T+ +   PP   +      V  G  V F C+AT  P    +   +G   +L +  P
Sbjct: 303 SATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 362

Query: 225 -----RLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPILQAKPEPV 271
                R  V          V         C+  N  GS      L+V    ++  +P PV
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT--DVIADRPPPV 420

Query: 272 ------SVDVGEDASF--SCAWRGNPLPRVTWTRRGG---------AQVLGSGATLRLPS 314
                 +  V  D +F  SC   G+P+P + W + G           Q+      +R   
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 315 VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFAS 374
           +G  D G Y C A    SG    +A   +     PV     + P  +  P+         
Sbjct: 481 LG--DTGRYTCIASTP-SGEATWSAYIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVTD 535

Query: 375 PAPDAVVWSWDEGFLEAGSQGRFLVETF 402
            + + V  SW        +   +++E F
Sbjct: 536 VSRNTVTLSWQPNLNSGATPTSYIIEAF 563



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 51/188 (27%), Positives = 69/188 (36%), Gaps = 13/188 (6%)

Query: 36  HDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVA-GVPAN 93
           H L IR V   D  SY C A    G     A L V V  E P  +  P   +VA G    
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333

Query: 94  LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST--LTLTPFSHDDGAT 151
             C + G+  P P + W R+G       F     +  +  SV  T  LT+T     D   
Sbjct: 334 FQCEATGN--PQPAIFWRREG--SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389

Query: 152 FVCR----ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT 207
           ++C+    A S       +    ++ + PP +       TV      +  C AT   PV 
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS-PVP 448

Query: 208 GYRWAKGG 215
              W K G
Sbjct: 449 TILWRKDG 456


>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
           sapiens]
          Length = 1615

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 107/407 (26%), Positives = 157/407 (38%), Gaps = 48/407 (11%)

Query: 76  PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 130
           P+++  PS  +V+ G PA L C++ G  RPTP + W++ G  +    D    H+ LL  G
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEG--RPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 131 TPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYP---PEVTLSASPHT 187
           +   +   +     S  D   +VC AR+     G   +   SL+      +   + S   
Sbjct: 87  SLFFLR--IVHGRKSRPDEGVYVCVARNYL---GEAVSHNASLEVAILRDDFRQNPSDVM 141

Query: 188 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTEPVSC 241
           V  GE  +  CQ     P     W K GSP+      +  RG +L +            C
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201

Query: 242 EVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGG 300
             +N VG      A L VL  P    +P  ++V V + A F C  RG+P+P V W +  G
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261

Query: 301 -----AQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA------PP 349
                   +    TL++  V   D G Y C AE  +     G AEA  T+        P 
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV-----GKAEASATLTVQVGSEPPH 316

Query: 350 VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRG 409
            V         L      QC    +P P A+ W         GSQ   L+ ++  P+S  
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWR------REGSQN--LLFSYQPPQSSS 367

Query: 410 GLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL 456
                    L I+  Q SD    + C   N  G    +A L   D++
Sbjct: 368 RFSVSQTGDLTITNVQRSDVG-YYICQTLNVAGSIITKAYLEVTDVI 413



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 74/301 (24%), Positives = 109/301 (36%), Gaps = 46/301 (15%)

Query: 175 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 230
           +PP +    S   V +GE     C+A  +P  T   W KGG  V       R  R+ + +
Sbjct: 27  FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT-IEWYKGGERVETDKDDPRSHRMLLPS 85

Query: 231 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 276
            + F    V             C   N +G A + + +L+V +     +  P  V V VG
Sbjct: 86  GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145

Query: 277 EDASFSC-AWRGNPLPRVTWTRRGG------AQVLGSGATLRLPSVGPEDAGDYVCRAEA 329
           E A   C   RG+P P ++W + G        ++   G  L +      DAG YVC    
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC-VGT 204

Query: 330 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFL 389
            + G R         +  P  V    +    +   A  +C     P P  V W  D+G L
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-TVRWRKDDGEL 263

Query: 390 EAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQAS 449
                          P+SR  +       L I      D   S+ C A N +G+  A A+
Sbjct: 264 ---------------PKSRYEIRDD--HTLKIRKVTAGDMG-SYTCVAENMVGKAEASAT 305

Query: 450 L 450
           L
Sbjct: 306 L 306



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 84/388 (21%), Positives = 135/388 (34%), Gaps = 51/388 (13%)

Query: 47  DEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPS-VSLVAGVPANLTCRSRGDARPT 105
           D   Y C  T   +  R +++  L   E P  +  PS +++     A   C +RGD  P 
Sbjct: 195 DAGKYVCVGTNM-VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD--PV 251

Query: 106 PELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR 165
           P + W +D    DG      L K       + TL +   +  D  ++ C A +       
Sbjct: 252 PTVRWRKD----DGE-----LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA 302

Query: 166 DTAITLSL-QYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGP 224
              +T+ +   PP   +      V  G  V F C+AT  P    +   +G   +L +  P
Sbjct: 303 SATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 362

Query: 225 -----RLEVVADASFLTEPVS--------CEVSNAVGSANRSTALDVLFGPILQAKPEPV 271
                R  V          V         C+  N  GS      L+V    ++  +P PV
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT--DVIADRPPPV 420

Query: 272 ------SVDVGEDASF--SCAWRGNPLPRVTWTRRGG---------AQVLGSGATLRLPS 314
                 +  V  D +F  SC   G+P+P + W + G           Q+      +R   
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 315 VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFAS 374
           +G  D G Y C A    SG    +A   +     PV     + P  +  P+         
Sbjct: 481 LG--DTGRYTCIASTP-SGEATWSAYIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVTD 535

Query: 375 PAPDAVVWSWDEGFLEAGSQGRFLVETF 402
            + + V  SW        +   +++E F
Sbjct: 536 VSRNTVTLSWQPNLNSGATPTSYIIEAF 563



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 51/188 (27%), Positives = 69/188 (36%), Gaps = 13/188 (6%)

Query: 36  HDLHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVA-GVPAN 93
           H L IR V   D  SY C A    G     A L V V  E P  +  P   +VA G    
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVT 333

Query: 94  LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVEST--LTLTPFSHDDGAT 151
             C + G+  P P + W R+G       F     +  +  SV  T  LT+T     D   
Sbjct: 334 FQCEATGN--PQPAIFWRREG--SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389

Query: 152 FVCR----ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT 207
           ++C+    A S       +    ++ + PP +       TV      +  C AT   PV 
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS-PVP 448

Query: 208 GYRWAKGG 215
              W K G
Sbjct: 449 TILWRKDG 456


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 101/400 (25%), Positives = 156/400 (39%), Gaps = 57/400 (14%)

Query: 74  EAPQVLGGPS-VSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTP 132
           E P++   P    + +G     TCR+ G+  P PE++W R+   L   T  +  L +   
Sbjct: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGN--PKPEIIWLRNNNELSMKTDSRLNLLD--- 298

Query: 133 GSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQY---PPEVTLSASPHTVQ 189
              + TL +      D   + C A++ A   G      ++L+Y   P   T    P   +
Sbjct: 299 ---DGTLMIQNTQETDQGIYQCMAKNVA---GEVKTQEVTLRYFGSPARPTFVIQPQNTE 352

Query: 190 E--GEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPV-------- 239
              GE V   C AT  PP     W +G    L    PR+ +        + V        
Sbjct: 353 VLVGESVTLECSATGHPPPR-ISWTRGDRTPLPV-DPRVNITPSGGLYIQNVVQGDSGEY 410

Query: 240 SCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG 299
           +C  +N + S + +  + V   P     P+   V  G+   F C  +GNP P + WT +G
Sbjct: 411 ACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWT-KG 469

Query: 300 GAQ--------VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV 351
           G+Q        VL SG TLR+  V   D G Y C+A   + G +   A   +     PV 
Sbjct: 470 GSQLSVDRRHLVLSSG-TLRISGVALHDQGQYECQA-VNIIGSQKVVAHLTVQPRVTPVF 527

Query: 352 TALHSAPAFLRGP-ARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGG 410
            ++ S      G   +L C     P P A+ W+ D   ++    G+F +    +PE    
Sbjct: 528 ASIPSDTTVEVGANVQLPCSSQGEPEP-AITWNKDG--VQVTESGKFHI----SPE---- 576

Query: 411 LGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 450
                   L I+    +D  R + C ARN +G       L
Sbjct: 577 ------GFLTINDVGPADAGR-YECVARNTIGSASVSMVL 609



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 42/151 (27%), Positives = 64/151 (42%), Gaps = 18/151 (11%)

Query: 38  LHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGG-PSVSLV-AGVPANLT 95
           L I  V L D+  YECQA    + S+    H+ V P    V    PS + V  G    L 
Sbjct: 487 LRISGVALHDQGQYECQAVNI-IGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLP 545

Query: 96  CRSRGDARPTPELLWFRDGV-LLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVC 154
           C S+G+  P P + W +DGV + +   FH          S E  LT+      D   + C
Sbjct: 546 CSSQGE--PEPAITWNKDGVQVTESGKFHI---------SPEGFLTINDVGPADAGRYEC 594

Query: 155 RARSQALPTGRDTAITLSLQYPPEVTLSASP 185
            AR+          +++++   P+V+ +  P
Sbjct: 595 VARNTIGSASVSMVLSVNV---PDVSRNGDP 622


>gi|13489095 sialoadhesin precursor [Homo sapiens]
          Length = 1709

 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 119/437 (27%), Positives = 177/437 (40%), Gaps = 70/437 (16%)

Query: 45   LEDEASYECQATQA-GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDAR 103
            LE+E  Y C+A+ A G  S  A  +     +A  +   PS +L  G  ANLTC    +A 
Sbjct: 681  LEEEGLYLCEASNALGNASTSATFN----GQATVLAIAPSHTLQEGTEANLTCNVSREAA 736

Query: 104  PTP-ELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALP 162
             +P    WFR+GVL                G +E T+TL P +  D A + CR  ++A  
Sbjct: 737  GSPANFSWFRNGVLW-------------AQGPLE-TVTLLPVARTDAALYACRILTEA-G 781

Query: 163  TGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT------GYRWAKGGS 216
                T + LS+ YPP+    ++   + +G   +F+C   ++P          +  A    
Sbjct: 782  AQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLG 841

Query: 217  PVLGARGPRLEVVADASFLTEPVS-----------CEVSNAVGSANRSTALDVLFGPILQ 265
            P + + G R +  A+A+ L   V            CE +N +GS+N S    V  G  +Q
Sbjct: 842  PQVPSHG-RFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR-GAWVQ 899

Query: 266  AKPEPVSVDVGEDASFSCAWRGNPLPRVT---WTRRGGAQVLGSGATLRLPSVGPEDAGD 322
              P P  +  G+    SC      +P  T   W R G      + ATLR  ++    AG 
Sbjct: 900  VSPSP-ELQEGQAVVLSCQVHTG-VPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGA 957

Query: 323  YVCRAEAGLSGLRGGAAEARLTVNAPP----VVTALHSAPAFLRGPARLQCLVFASPAP- 377
            Y C+A+A  S     AA   L V+  P    + T + + P  L     L C V + P   
Sbjct: 958  YHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRL---GLLLCRVDSDPPAQ 1014

Query: 378  ------DAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSR 431
                  D +V S  +G    G +G        +P     + P  +  L I G    D   
Sbjct: 1015 LRLLHGDRLVASTLQGV--GGPEG-------SSPRLHVAVAPNTLR-LEIHGAMLED-EG 1063

Query: 432  SFNCSARNRLGEGGAQA 448
             + C A N LG+  A A
Sbjct: 1064 VYICEASNTLGQASASA 1080



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 84/336 (25%), Positives = 130/336 (38%), Gaps = 51/336 (15%)

Query: 38  LHIRPVELEDEASYECQATQA--GLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLT 95
           LH+      D   Y CQA      L S P  LH+ +     +V   P+  ++      L 
Sbjct: 290 LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA----EVQVSPAGPILENQTVTLV 345

Query: 96  CRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCR 155
           C +  +A       W+++ VLL+ A  H              TL L   +  D   + C 
Sbjct: 346 CNTPNEAPSDLRYSWYKNHVLLEDAHSH--------------TLRLHLATRADTGFYFCE 391

Query: 156 ARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT------GY 209
            ++    + R   +++ + +PP   +  +    Q G   I  C   ++P  T      G+
Sbjct: 392 VQN-VHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGH 450

Query: 210 RWAKGG-----SPVL-GARGP---RLEVVADASFLTEPVSCEVSNAVGSAN-----RSTA 255
             A        SP   G  GP   RLE+       +    C  +N++G+A       + A
Sbjct: 451 ILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANA 510

Query: 256 LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLP--RVTWTRRGGAQVLGSGATLRLP 313
             +L  P  +       V  G+  + SC    +P P  R +W   G     G G++L LP
Sbjct: 511 ARLLISPAAE-------VVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLP 563

Query: 314 SVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPP 349
           +    DAG Y CRA  G S   G ++ A LTV  PP
Sbjct: 564 AASSTDAGSYHCRARDGHSA-SGPSSPAVLTVLYPP 598



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 115/477 (24%), Positives = 165/477 (34%), Gaps = 67/477 (14%)

Query: 38   LHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCR 97
            L +R + L D  SY C+AT   L S    L   V     QV   PS  L  G    L+C+
Sbjct: 861  LEVRELGLGDSGSYRCEATNV-LGSSNTSLFFQVRGAWVQV--SPSPELQEGQAVVLSCQ 917

Query: 98   SRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRAR 157
                        W+RDG  L  +T               +TL     +      + C+A+
Sbjct: 918  VHTGVPEGTSYRWYRDGQPLQEST--------------SATLRFAAITLTQAGAYHCQAQ 963

Query: 158  SQ-ALPTGRDTAITLSLQYPP-EVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKG- 214
            +  +  T     I+L + Y P  VTL+    T   G   + LC+  + PP    R   G 
Sbjct: 964  APGSATTSLAAPISLHVSYAPRHVTLTTLMDT-GPGRLGLLLCRVDSDPPAQ-LRLLHGD 1021

Query: 215  ---GSPVLGARG-----PRLEVVADASFLTEPVS-----------CEVSNAVGSANRSTA 255
                S + G  G     PRL V    + L   +            CE SN +G A+ S  
Sbjct: 1022 RLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASAD 1081

Query: 256  LDVLFGPILQAKPEPVSVDVGEDASFSC-AWRGNPLPRVTWTRRGGAQVLGSGATLRLPS 314
             D      +Q  P   +V  G+  + +C  W  +P  ++T+T     Q      ++ LP+
Sbjct: 1082 FDAQ-AVNVQVWP-GATVREGQLVNLTCLVWTTHP-AQLTYTWYQDGQQRLDAHSIPLPN 1138

Query: 315  VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFAS 374
            V   DA  Y C          G     R    + P+   +  AP  LR    L+      
Sbjct: 1139 VTVRDATSYRC----------GVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQL 1188

Query: 375  PAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFN 434
                  V S     L     GR L  +  A        P  +  L + G Q  D    ++
Sbjct: 1189 ALVLCTVDSRPPAQLALSHAGRLLASSTAASV------PNTLR-LELRGPQPRD-EGFYS 1240

Query: 435  CSARNRLGEGGAQASLG----RRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHS 487
            CSAR+ LG+      L     R  L P   +  G     T          L  W H+
Sbjct: 1241 CSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHN 1297



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 111/483 (22%), Positives = 164/483 (33%), Gaps = 71/483 (14%)

Query: 38   LHIRPVELEDEASYECQA-TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTC 96
            L +R  +  DE  Y C A +  G  +   +L +    E  +V+  P  ++  G P  +TC
Sbjct: 1226 LELRGPQPRDEGFYSCSARSPLGQANTSLELRL----EGVRVILAPEAAVPEGAPITVTC 1281

Query: 97   RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRA 156
                   PT    W+ +G            L+EG   S    L+    +      + C+A
Sbjct: 1282 ADPAAHAPT-LYTWYHNG----------RWLQEGPAAS----LSFLVATRAHAGAYSCQA 1326

Query: 157  RSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVT--------- 207
            +  A  T       L + Y P+  + +S    +     +  C   ++PP           
Sbjct: 1327 Q-DAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKV 1385

Query: 208  ------GYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFG 261
                   +  A G   V  AR      V D     +   C   N +GS +    L V  G
Sbjct: 1386 LATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV-EG 1444

Query: 262  PILQAKPEPVSVDVGEDASFSCAWRGNPLP----RVTW---TRRGGAQVLGSGATLRLPS 314
              + A+P  + V  G   + SC   G P P       W    RR  A+ +    TL    
Sbjct: 1445 ARVVAEP-GLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV---PTLAFTH 1500

Query: 315  VGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNA-----PPVVTALHSAPAFLRGPARLQC 369
            V    AG Y C AE       G AA A + +        P +         LRG   L C
Sbjct: 1501 VARAQAGMYHCLAELP----TGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRG--ILDC 1554

Query: 370  LVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPA-PESRGGLGPGLISVLHISGTQESD 428
             V + P     +         +  QG       PA P       P  + V  I   + SD
Sbjct: 1555 RVDSEPLASLTLHLGSRLVASSQPQGA------PAEPHIHVLASPNALRV-DIEALRPSD 1607

Query: 429  FSRSFNCSARNRLGEGGAQASLGRRDL--LPTVRIVAGVAAATTTLLMVITGVALC-CWR 485
                + CSA N LG        G R L  L   + +  V      LL+++ G+  C  WR
Sbjct: 1608 -QGEYICSASNVLGSASTSTYFGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWR 1666

Query: 486  HSK 488
              +
Sbjct: 1667 RRR 1669



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 101/442 (22%), Positives = 154/442 (34%), Gaps = 74/442 (16%)

Query: 53  CQATQAGLRSRPA-QLHVLVPPEAPQVLGGPSV-SLVAGVPANLTCRSRGDARPTPELLW 110
           CQ + A  R++    L V   P+  ++L  PS  +++ G    LTC+          + W
Sbjct: 217 CQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKW 276

Query: 111 FRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAIT 170
            +DGV L   T                 L L   +  D   + C+A +     G   +  
Sbjct: 277 LKDGVRLQTKT---------------GVLHLPQAAWSDAGVYTCQAEN---GVGSLVSPP 318

Query: 171 LSLQ-YPPEVTLS-ASPHTVQEGEKVIFLCQATAQPPV-TGYRWAKGGSPVLGARGPRLE 227
           +SL  +  EV +S A P  + E + V  +C    + P    Y W K    +  A    L 
Sbjct: 319 ISLHIFMAEVQVSPAGP--ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLR 376

Query: 228 VVADASFLTEPVSCEVSNAVGSANRSTALDVLFG--PILQAKPEPVSVDVGEDASFSCAW 285
           +       T    CEV N  GS  RS  + V+    P+       +    G      C+ 
Sbjct: 377 LHLATRADTGFYFCEVQNVHGS-ERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSV 435

Query: 286 RGNPLPRVTWTRRGGAQVLGSGATLRLP----SVGPE------------DAGDYVCRAEA 329
              PL  +  +  G      SG +   P    + GP             D+G+Y C A  
Sbjct: 436 VSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATN 495

Query: 330 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPA-RLQCLVFASPAPDA-VVWSWDEG 387
            L     G A + L  +A      +  A   + G A  L C    SP PDA   W  +  
Sbjct: 496 SL-----GNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGA 550

Query: 388 FLEAGSQGRFLVETFPAPE-------------SRGGLGPGLISVLHISGTQESDFSRSFN 434
            L  G     L+    + +             + G   P +++VL+    ++  F+    
Sbjct: 551 LLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLY--PPRQPTFT---- 604

Query: 435 CSARNRLGEGGAQASLGRRDLL 456
                RL    A A  GRR LL
Sbjct: 605 ----TRLDLDAAGAGAGRRGLL 622


>gi|11225258 myelin associated glycoprotein isoform a precursor
           [Homo sapiens]
          Length = 626

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 122/467 (26%), Positives = 179/467 (38%), Gaps = 44/467 (9%)

Query: 68  HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 127
           +++VPPE   V+ G  V +   VP N            PEL W     L + A   +   
Sbjct: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191

Query: 128 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 187
            EGT   V S L   P    +G    C+A         +   ++ ++YPP +    S   
Sbjct: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250

Query: 188 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 245
             EG  V  LC A + PP     W + G+ +  A    L +  +     E    +C   N
Sbjct: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309

Query: 246 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 302
           A G  NR+  L V++ P        +    GE  S  C+ + NP P +T  +        
Sbjct: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369

Query: 303 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 362
           +  S   L LP+V PED G+Y C AE    G R  A    L+V   PV+  L S  A  R
Sbjct: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425

Query: 363 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 422
              +  C+V ++P P               S+  F+         R GL   L S+L + 
Sbjct: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477

Query: 423 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 482
           G  ++       C+ARN  G    +        L   +I  G   A     ++I   A+ 
Sbjct: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530

Query: 483 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSR 522
           C+       ++   S SFS   N   +  SSD   S  PE+ E+  R
Sbjct: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYESERR 576


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 115/434 (26%), Positives = 169/434 (38%), Gaps = 56/434 (12%)

Query: 76  PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 130
           P+++  PS  +V+ G P  L C++ G  RPTP + W++DG  +    D    H+ LL  G
Sbjct: 47  PRIVEHPSDVIVSKGEPTTLNCKAEG--RPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104

Query: 131 TPGSVESTLTLTPFSHDDGATFVCRARSQ-ALPTGRDTAITLSL------QYPPEVTLSA 183
           +   +   +     S  D  ++VC AR+       R+ ++ ++L      Q P +V ++A
Sbjct: 105 SLFFLR--IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA 162

Query: 184 SPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTE 237
                  GE  I  CQ     P     W K    +      +  RG +L +         
Sbjct: 163 -------GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAG 215

Query: 238 PVSCEVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWT 296
             +C  +N VG  +   A L V   P    +P    V   E   F C  +G+P P V W 
Sbjct: 216 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 275

Query: 297 RRG-----GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV 351
           +       G   +    TLR+      D G Y+C AE  +  +    A A LTV APP  
Sbjct: 276 KDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKME---ASATLTVRAPPQF 332

Query: 352 TALHSAPAFLRG-PARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGG 410
                     +G      C    +P P AV W       + GSQ          P SR  
Sbjct: 333 VVRPRDQIVAQGRTVTFPCETKGNPQP-AVFWQ------KEGSQNLLFPNQPQQPNSRCS 385

Query: 411 LGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL---PTVRIVAGVAA 467
           + P     L I+  Q SD +  + C A    G   A+A L   D+L   P   I+ G A 
Sbjct: 386 VSP--TGDLTITNIQRSD-AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPAN 442

Query: 468 ATTTLLMVITGVAL 481
            T    + + G AL
Sbjct: 443 QT----LAVDGTAL 452



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 113/435 (25%), Positives = 151/435 (34%), Gaps = 66/435 (15%)

Query: 47  DEASYECQATQ--AGLRSRPAQLHV-LVPPEAPQVLGGPSVSLVAGVPANLTCRS-RGDA 102
           DE SY C A        SR A L V L+  +  Q      V + AG PA L C+  RG  
Sbjct: 120 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ--NPTDVVVAAGEPAILECQPPRG-- 175

Query: 103 RPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALP 162
            P P + W +D V +D         KE         L ++     D   + C   +    
Sbjct: 176 HPEPTIYWKKDKVRIDD--------KEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGE 227

Query: 163 TGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGAR 222
              D A  L++   P          V E E V F CQ    P  T  RW K  + +   R
Sbjct: 228 RDSDPA-ELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT-VRWKKDDADLPRGR 285

Query: 223 GP-----RLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGE 277
                   L +    S       C   N VG    S  L V   P    +P    V  G 
Sbjct: 286 YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGR 345

Query: 278 DASFSCAWRGNPLPRVTWTRRGGAQVL--------------GSGATLRLPSVGPEDAGDY 323
             +F C  +GNP P V W + G   +L                   L + ++   DAG Y
Sbjct: 346 TVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 405

Query: 324 VCRAEAGLSGLRGGA---AEARLTVNAPPVVTALHSAPA----FLRGPARLQCLVFASPA 376
           +C+A      +   A       LT   PP++      PA     + G A L+C     P 
Sbjct: 406 ICQALTVAGSILAKAQLEVTDVLTDRPPPIIL---QGPANQTLAVDGTALLKCKATGDPL 462

Query: 377 PDAVVWSW-DEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNC 435
           P   V SW  EGF            TFP  + R  +       L I   + SD + ++ C
Sbjct: 463 P---VISWLKEGF------------TFPGRDPRATIQEQ--GTLQIKNLRISD-TGTYTC 504

Query: 436 SARNRLGEGGAQASL 450
            A +  GE    A L
Sbjct: 505 VATSSSGETSWSAVL 519



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 75/311 (24%), Positives = 113/311 (36%), Gaps = 66/311 (21%)

Query: 175 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 230
           +PP +    S   V +GE     C+A  +P  T   W K G  V       R  R+ + +
Sbjct: 45  FPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPT-IEWYKDGERVETDKDDPRSHRMLLPS 103

Query: 231 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 276
            + F    V             C   N +G A +R+ +L+V L     +  P  V V  G
Sbjct: 104 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 163

Query: 277 EDASFSC-AWRGNPLPRVTWTR------RGGAQVLGSGATLRLPSVGPEDAGDYVCRAEA 329
           E A   C   RG+P P + W +          ++   G  L + +    DAG Y C    
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTC-VGT 222

Query: 330 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGP----------ARLQCLVFASPAPDA 379
            + G R          ++ P    +   P FLR P             +C V   P P  
Sbjct: 223 NMVGER----------DSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQP-T 271

Query: 380 VVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARN 439
           V W  D+  L    +GR+ ++                  L I  T  +D   ++ C A N
Sbjct: 272 VRWKKDDADL---PRGRYDIKD--------------DYTLRIKKTMSTD-EGTYMCIAEN 313

Query: 440 RLGEGGAQASL 450
           R+G+  A A+L
Sbjct: 314 RVGKMEASATL 324



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 56/222 (25%), Positives = 78/222 (35%), Gaps = 49/222 (22%)

Query: 245 NAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTR------- 297
           N  G  +R    D  F P +   P  V V  GE  + +C   G P P + W +       
Sbjct: 32  NGQGQGSRLRQED--FPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVET 89

Query: 298 -----RGGAQVLGSGATLRLPSV----GPEDAGDYVC--RAEAGLSGLRGGAAEARL--- 343
                R    +L SG+   L  V       D G YVC  R   G +  R  + E  L   
Sbjct: 90  DKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRD 149

Query: 344 --TVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVET 401
               N   VV A          PA L+C          + W  D+  ++   + R  +  
Sbjct: 150 DFRQNPTDVVVAAGE-------PAILECQPPRGHPEPTIYWKKDKVRID-DKEERISI-- 199

Query: 402 FPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGE 443
                 RGG        L IS T++SD +  + C   N +GE
Sbjct: 200 ------RGG-------KLMISNTRKSD-AGMYTCVGTNMVGE 227


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 115/434 (26%), Positives = 169/434 (38%), Gaps = 56/434 (12%)

Query: 76  PQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLL----DGATFHQTLLKEG 130
           P+++  PS  +V+ G P  L C++ G  RPTP + W++DG  +    D    H+ LL  G
Sbjct: 31  PRIVEHPSDVIVSKGEPTTLNCKAEG--RPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88

Query: 131 TPGSVESTLTLTPFSHDDGATFVCRARSQ-ALPTGRDTAITLSL------QYPPEVTLSA 183
           +   +   +     S  D  ++VC AR+       R+ ++ ++L      Q P +V ++A
Sbjct: 89  SLFFLR--IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA 146

Query: 184 SPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPV------LGARGPRLEVVADASFLTE 237
                  GE  I  CQ     P     W K    +      +  RG +L +         
Sbjct: 147 -------GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAG 199

Query: 238 PVSCEVSNAVGSANRSTA-LDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWT 296
             +C  +N VG  +   A L V   P    +P    V   E   F C  +G+P P V W 
Sbjct: 200 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259

Query: 297 RRG-----GAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVV 351
           +       G   +    TLR+      D G Y+C AE  +  +    A A LTV APP  
Sbjct: 260 KDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKME---ASATLTVRAPPQF 316

Query: 352 TALHSAPAFLRG-PARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGG 410
                     +G      C    +P P AV W       + GSQ          P SR  
Sbjct: 317 VVRPRDQIVAQGRTVTFPCETKGNPQP-AVFWQ------KEGSQNLLFPNQPQQPNSRCS 369

Query: 411 LGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLL---PTVRIVAGVAA 467
           + P     L I+  Q SD +  + C A    G   A+A L   D+L   P   I+ G A 
Sbjct: 370 VSP--TGDLTITNIQRSD-AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPAN 426

Query: 468 ATTTLLMVITGVAL 481
            T    + + G AL
Sbjct: 427 QT----LAVDGTAL 436



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 113/435 (25%), Positives = 151/435 (34%), Gaps = 66/435 (15%)

Query: 47  DEASYECQATQ--AGLRSRPAQLHV-LVPPEAPQVLGGPSVSLVAGVPANLTCRS-RGDA 102
           DE SY C A        SR A L V L+  +  Q      V + AG PA L C+  RG  
Sbjct: 104 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ--NPTDVVVAAGEPAILECQPPRG-- 159

Query: 103 RPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALP 162
            P P + W +D V +D         KE         L ++     D   + C   +    
Sbjct: 160 HPEPTIYWKKDKVRIDD--------KEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGE 211

Query: 163 TGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGAR 222
              D A  L++   P          V E E V F CQ    P  T  RW K  + +   R
Sbjct: 212 RDSDPA-ELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT-VRWKKDDADLPRGR 269

Query: 223 GP-----RLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGE 277
                   L +    S       C   N VG    S  L V   P    +P    V  G 
Sbjct: 270 YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGR 329

Query: 278 DASFSCAWRGNPLPRVTWTRRGGAQVL--------------GSGATLRLPSVGPEDAGDY 323
             +F C  +GNP P V W + G   +L                   L + ++   DAG Y
Sbjct: 330 TVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 389

Query: 324 VCRAEAGLSGLRGGA---AEARLTVNAPPVVTALHSAPA----FLRGPARLQCLVFASPA 376
           +C+A      +   A       LT   PP++      PA     + G A L+C     P 
Sbjct: 390 ICQALTVAGSILAKAQLEVTDVLTDRPPPIIL---QGPANQTLAVDGTALLKCKATGDPL 446

Query: 377 PDAVVWSW-DEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNC 435
           P   V SW  EGF            TFP  + R  +       L I   + SD + ++ C
Sbjct: 447 P---VISWLKEGF------------TFPGRDPRATIQEQ--GTLQIKNLRISD-TGTYTC 488

Query: 436 SARNRLGEGGAQASL 450
            A +  GE    A L
Sbjct: 489 VATSSSGETSWSAVL 503



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 75/311 (24%), Positives = 113/311 (36%), Gaps = 66/311 (21%)

Query: 175 YPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVL----GARGPRLEVVA 230
           +PP +    S   V +GE     C+A  +P  T   W K G  V       R  R+ + +
Sbjct: 29  FPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPT-IEWYKDGERVETDKDDPRSHRMLLPS 87

Query: 231 DASFLTEPVS------------CEVSNAVGSA-NRSTALDV-LFGPILQAKPEPVSVDVG 276
            + F    V             C   N +G A +R+ +L+V L     +  P  V V  G
Sbjct: 88  GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147

Query: 277 EDASFSC-AWRGNPLPRVTWTR------RGGAQVLGSGATLRLPSVGPEDAGDYVCRAEA 329
           E A   C   RG+P P + W +          ++   G  L + +    DAG Y C    
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTC-VGT 206

Query: 330 GLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGP----------ARLQCLVFASPAPDA 379
            + G R          ++ P    +   P FLR P             +C V   P P  
Sbjct: 207 NMVGER----------DSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQP-T 255

Query: 380 VVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARN 439
           V W  D+  L    +GR+ ++                  L I  T  +D   ++ C A N
Sbjct: 256 VRWKKDDADL---PRGRYDIKD--------------DYTLRIKKTMSTD-EGTYMCIAEN 297

Query: 440 RLGEGGAQASL 450
           R+G+  A A+L
Sbjct: 298 RVGKMEASATL 308


>gi|18104957 myelin associated glycoprotein isoform b precursor
           [Homo sapiens]
          Length = 582

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 121/464 (26%), Positives = 178/464 (38%), Gaps = 44/464 (9%)

Query: 68  HVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLL 127
           +++VPPE   V+ G  V +   VP N            PEL W     L + A   +   
Sbjct: 142 NIVVPPE---VVAGTEVEVSCMVPDNCP-------ELRPELSWLGHEGLGEPAVLGRLRE 191

Query: 128 KEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 187
            EGT   V S L   P    +G    C+A         +   ++ ++YPP +    S   
Sbjct: 192 DEGTWVQV-SLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVE 250

Query: 188 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP--VSCEVSN 245
             EG  V  LC A + PP     W + G+ +  A    L +  +     E    +C   N
Sbjct: 251 AIEGSHVSLLCGADSNPPPL-LTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAEN 309

Query: 246 AVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG---GAQ 302
           A G  NR+  L V++ P        +    GE  S  C+ + NP P +T  +        
Sbjct: 310 AYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTV 369

Query: 303 VLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLR 362
           +  S   L LP+V PED G+Y C AE    G R  A    L+V   PV+  L S  A  R
Sbjct: 370 IYESELQLELPAVSPEDDGEYWCVAE-NQYGQR--ATAFNLSVEFAPVL-LLESHCAAAR 425

Query: 363 GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHIS 422
              +  C+V ++P P               S+  F+         R GL   L S+L + 
Sbjct: 426 DTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVY------SERSGL--VLTSILTLR 477

Query: 423 GTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 482
           G  ++       C+ARN  G    +        L   +I  G   A     ++I   A+ 
Sbjct: 478 G--QAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKI--GPVGAVVAFAILI---AIV 530

Query: 483 CW-------RHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEET 519
           C+       ++   S SFS   N   +  SSD   S  PE+ E+
Sbjct: 531 CYITQTRRKKNVTESPSFSAGDN-PPVLFSSDFRISGAPEKYES 573


>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor
           [Homo sapiens]
          Length = 1070

 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 100/364 (27%), Positives = 138/364 (37%), Gaps = 37/364 (10%)

Query: 45  LEDEASYECQA----TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRG 100
           L+D  +++C A    T    RS  A  ++      P VL  P+          +T R   
Sbjct: 93  LQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHI 152

Query: 101 DARPTPELLWFRDGV-LLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQ 159
           D  P P   WFRDG  L DG + H       T  S E  LTL P   +    + C A S 
Sbjct: 153 DGHPRPTYQWFRDGTPLSDGQSNH-------TVSSKERNLTLRPAGPEHSGLYSCCAHSA 205

Query: 160 ALPTGRDTAITLSL--QYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSP 217
                     TLS+  +    V L+     V   E+ +F CQ +AQPP +     +  +P
Sbjct: 206 FGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETP 265

Query: 218 VLGARGP----RLEVVADASFL---TEPVSCEVSNAVGSANRSTAL---DVLFGPILQAK 267
           +     P    R  V A+ S L     P +  +   +G   R   +     L    ++  
Sbjct: 266 ITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDM 325

Query: 268 P--EPVSVDVGEDASFSC-AWRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVGPED 319
           P  EP     G +   +C   +G P P V W   G       +V   G  L L ++   D
Sbjct: 326 PLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESD 385

Query: 320 AGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRG-PARLQCLVFASPAPD 378
           AG Y C A A L+G R    +  +TV   P             G P  L CL  A+P P 
Sbjct: 386 AGVYTCHA-ANLAGQR--RQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKP- 441

Query: 379 AVVW 382
            VVW
Sbjct: 442 TVVW 445



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 95/384 (24%), Positives = 137/384 (35%), Gaps = 47/384 (12%)

Query: 32  ANGQHDLHIRPVELEDEASYECQATQAGLRSRP----AQLHVLVPPEAPQVLGGPSVSLV 87
           ANG   L +  V   +   Y C     G R  P    A LH+    + P  L  P V   
Sbjct: 282 ANGS--LLLTQVRPRNAGIYRCIGQ--GQRGPPIILEATLHLAEIEDMP--LFEPRV-FT 334

Query: 88  AGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHD 147
           AG    +TC       P P + W   GV L     H  + ++G        L L   +  
Sbjct: 335 AGSEERVTCLPP-KGLPEPSVWWEHAGVRLPT---HGRVYQKG------HELVLANIAES 384

Query: 148 DGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLC--QATAQPP 205
           D   + C A + A    +D  IT++    P          ++EG+     C  QAT +P 
Sbjct: 385 DAGVYTCHAANLAGQRRQDVNITVATV--PSWLKKPQDSQLEEGKPGYLDCLTQATPKPT 442

Query: 206 VTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALD 257
           V  YR     + +L +   R EV  + +     V         C  S   GS      + 
Sbjct: 443 VVWYR-----NQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQ 497

Query: 258 VLFGPILQAKPEPVS-VDVGEDASFSCAWRGNPLPRVTWTRRGGAQ----VLGSGATLRL 312
           VL        P+P   ++  ++A+  C+  G   P + W R  G+     V  +  TL  
Sbjct: 498 VLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHF 557

Query: 313 PSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRG-PARLQCLV 371
             V  +DAG+Y C A  G  G     A  +LTV                +G  A LQC  
Sbjct: 558 ARVTRDDAGNYTCIASNGPQGQI--RAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEA 615

Query: 372 FASPAPDAVVWSWDEGFLEAGSQG 395
              P P  + W   +  L+    G
Sbjct: 616 QGDPKP-LIQWKGKDRILDPTKLG 638



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 72/311 (23%), Positives = 113/311 (36%), Gaps = 37/311 (11%)

Query: 36  HDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS-LVAGVPAN 93
           H+L +  +   D   Y C A   AG R +   + V      P  L  P  S L  G P  
Sbjct: 374 HELVLANIAESDAGVYTCHAANLAGQRRQDVNITVAT---VPSWLKKPQDSQLEEGKPGY 430

Query: 94  LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 153
           L C ++  A P P ++W+R+ +L+   +  + + K GT       L +      DG  + 
Sbjct: 431 LDCLTQ--ATPKPTVVWYRNQMLISEDSRFE-VFKNGT-------LRINSVEVYDGTWYR 480

Query: 154 CRARSQA--LPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFL-CQATAQPPVTGYR 210
           C + + A  +       +   L++ P       P    E +K   + C AT +   T  +
Sbjct: 481 CMSSTPAGSIEAQARVQVLEKLKFTPP----PQPQQCMEFDKEATVPCSATGREKPT-IK 535

Query: 211 WAKGGSPVLGA----RGPRLEVVADASFLTEPVSCEVSNAV-GSANRSTALDVLFGPILQ 265
           W +     L          L             +C  SN   G       L V      +
Sbjct: 536 WERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFK 595

Query: 266 AKPEPVSVDVGEDASFSCAWRGNPLPRVTW---------TRRGGAQVLGSGATLRLPSVG 316
            +PE  +V  G  A   C  +G+P P + W         T+ G    +    +L +  V 
Sbjct: 596 VEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVA 655

Query: 317 PEDAGDYVCRA 327
           PED+G Y C A
Sbjct: 656 PEDSGRYTCIA 666



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 87/372 (23%), Positives = 124/372 (33%), Gaps = 39/372 (10%)

Query: 21  GWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQA---GLRSRPAQLHVLVPPEAPQ 77
           G S + +S    N    L +RP   E    Y C A  A      S+   L +     A  
Sbjct: 172 GQSNHTVSSKERN----LTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARV 227

Query: 78  VLGGPSVSLVAGVPANLTCRSRGDARPTPELLW-FRDGVLLDGATFHQTLLKEGTPGSVE 136
           VL    V +     A   C+    A+P P L W F D   +   +    L +        
Sbjct: 228 VLAPQDVVVARYEEAMFHCQF--SAQPPPSLQWLFEDETPITNRSRPPHLRRATV--FAN 283

Query: 137 STLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIF 196
            +L LT     +   + C  + Q  P     A TL L    ++ L   P     G +   
Sbjct: 284 GSLLLTQVRPRNAGIYRCIGQGQRGPPIILEA-TLHLAEIEDMPLF-EPRVFTAGSEERV 341

Query: 197 LCQATAQPPVTGYRWAKGGS--PVLGA---RGPRLEVVADASFLTEPVSCEVSNAVGSAN 251
            C      P     W   G   P  G    +G  L +   A       +C  +N  G   
Sbjct: 342 TCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRR 401

Query: 252 RSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRR-------GGAQVL 304
           +   + V   P    KP+   ++ G+     C  +  P P V W R           +V 
Sbjct: 402 QDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVF 461

Query: 305 GSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGP 364
            +G TLR+ SV   D   Y C     +S    G+ EA+  V    V+  L   P     P
Sbjct: 462 KNG-TLRINSVEVYDGTWYRC-----MSSTPAGSIEAQARVQ---VLEKLKFTPP----P 508

Query: 365 ARLQCLVFASPA 376
              QC+ F   A
Sbjct: 509 QPQQCMEFDKEA 520


>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor
           [Homo sapiens]
          Length = 1014

 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 100/364 (27%), Positives = 138/364 (37%), Gaps = 37/364 (10%)

Query: 45  LEDEASYECQA----TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRG 100
           L+D  +++C A    T    RS  A  ++      P VL  P+          +T R   
Sbjct: 93  LQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHI 152

Query: 101 DARPTPELLWFRDGV-LLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQ 159
           D  P P   WFRDG  L DG + H       T  S E  LTL P   +    + C A S 
Sbjct: 153 DGHPRPTYQWFRDGTPLSDGQSNH-------TVSSKERNLTLRPAGPEHSGLYSCCAHSA 205

Query: 160 ALPTGRDTAITLSL--QYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSP 217
                     TLS+  +    V L+     V   E+ +F CQ +AQPP +     +  +P
Sbjct: 206 FGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETP 265

Query: 218 VLGARGP----RLEVVADASFL---TEPVSCEVSNAVGSANRSTAL---DVLFGPILQAK 267
           +     P    R  V A+ S L     P +  +   +G   R   +     L    ++  
Sbjct: 266 ITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDM 325

Query: 268 P--EPVSVDVGEDASFSC-AWRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVGPED 319
           P  EP     G +   +C   +G P P V W   G       +V   G  L L ++   D
Sbjct: 326 PLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESD 385

Query: 320 AGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRG-PARLQCLVFASPAPD 378
           AG Y C A A L+G R    +  +TV   P             G P  L CL  A+P P 
Sbjct: 386 AGVYTCHA-ANLAGQR--RQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKP- 441

Query: 379 AVVW 382
            VVW
Sbjct: 442 TVVW 445



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 81/321 (25%), Positives = 118/321 (36%), Gaps = 43/321 (13%)

Query: 32  ANGQHDLHIRPVELEDEASYECQATQAGLRSRP----AQLHVLVPPEAPQVLGGPSVSLV 87
           ANG   L +  V   +   Y C     G R  P    A LH+    + P  L  P V   
Sbjct: 282 ANGS--LLLTQVRPRNAGIYRCIGQ--GQRGPPIILEATLHLAEIEDMP--LFEPRV-FT 334

Query: 88  AGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHD 147
           AG    +TC       P P + W   GV L     H  + ++G        L L   +  
Sbjct: 335 AGSEERVTCLPP-KGLPEPSVWWEHAGVRLPT---HGRVYQKG------HELVLANIAES 384

Query: 148 DGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLC--QATAQPP 205
           D   + C A + A    +D  IT++    P          ++EG+     C  QAT +P 
Sbjct: 385 DAGVYTCHAANLAGQRRQDVNITVATV--PSWLKKPQDSQLEEGKPGYLDCLTQATPKPT 442

Query: 206 VTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVS--------CEVSNAVGSANRSTALD 257
           V  YR     + +L +   R EV  + +     V         C  S   GS      + 
Sbjct: 443 VVWYR-----NQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQ 497

Query: 258 VLFGPILQAKPEPVS-VDVGEDASFSCAWRGNPLPRVTWTRRGGAQ----VLGSGATLRL 312
           VL        P+P   ++  ++A+  C+  G   P + W R  G+     V  +  TL  
Sbjct: 498 VLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHF 557

Query: 313 PSVGPEDAGDYVCRAEAGLSG 333
             V  +DAG+Y C A  G  G
Sbjct: 558 ARVTRDDAGNYTCIASNGPQG 578



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 87/372 (23%), Positives = 124/372 (33%), Gaps = 39/372 (10%)

Query: 21  GWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQA---GLRSRPAQLHVLVPPEAPQ 77
           G S + +S    N    L +RP   E    Y C A  A      S+   L +     A  
Sbjct: 172 GQSNHTVSSKERN----LTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARV 227

Query: 78  VLGGPSVSLVAGVPANLTCRSRGDARPTPELLW-FRDGVLLDGATFHQTLLKEGTPGSVE 136
           VL    V +     A   C+    A+P P L W F D   +   +    L +        
Sbjct: 228 VLAPQDVVVARYEEAMFHCQF--SAQPPPSLQWLFEDETPITNRSRPPHLRRATV--FAN 283

Query: 137 STLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIF 196
            +L LT     +   + C  + Q  P     A TL L    ++ L   P     G +   
Sbjct: 284 GSLLLTQVRPRNAGIYRCIGQGQRGPPIILEA-TLHLAEIEDMPLF-EPRVFTAGSEERV 341

Query: 197 LCQATAQPPVTGYRWAKGGS--PVLGA---RGPRLEVVADASFLTEPVSCEVSNAVGSAN 251
            C      P     W   G   P  G    +G  L +   A       +C  +N  G   
Sbjct: 342 TCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRR 401

Query: 252 RSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRR-------GGAQVL 304
           +   + V   P    KP+   ++ G+     C  +  P P V W R           +V 
Sbjct: 402 QDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVF 461

Query: 305 GSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGP 364
            +G TLR+ SV   D   Y C     +S    G+ EA+  V    V+  L   P     P
Sbjct: 462 KNG-TLRINSVEVYDGTWYRC-----MSSTPAGSIEAQARVQ---VLEKLKFTPP----P 508

Query: 365 ARLQCLVFASPA 376
              QC+ F   A
Sbjct: 509 QPQQCMEFDKEA 520



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 61/270 (22%), Positives = 97/270 (35%), Gaps = 28/270 (10%)

Query: 36  HDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS-LVAGVPAN 93
           H+L +  +   D   Y C A   AG R +   + V      P  L  P  S L  G P  
Sbjct: 374 HELVLANIAESDAGVYTCHAANLAGQRRQDVNITVAT---VPSWLKKPQDSQLEEGKPGY 430

Query: 94  LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 153
           L C ++  A P P ++W+R+ +L+   +  + + K GT       L +      DG  + 
Sbjct: 431 LDCLTQ--ATPKPTVVWYRNQMLISEDSRFE-VFKNGT-------LRINSVEVYDGTWYR 480

Query: 154 CRARSQA--LPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFL-CQATAQPPVTGYR 210
           C + + A  +       +   L++ P       P    E +K   + C AT +   T  +
Sbjct: 481 CMSSTPAGSIEAQARVQVLEKLKFTPP----PQPQQCMEFDKEATVPCSATGREKPT-IK 535

Query: 211 WAKGGSPVLGA----RGPRLEVVADASFLTEPVSCEVSNAV-GSANRSTALDVLFGPILQ 265
           W +     L          L             +C  SN   G       L V      +
Sbjct: 536 WERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFK 595

Query: 266 AKPEPVSVDVGEDASFSCAWRGNPLPRVTW 295
            +PE  +V  G  A   C  +G+P P + W
Sbjct: 596 VEPERTTVYQGHTALLQCEAQGDPKPLIQW 625


>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor
           [Homo sapiens]
          Length = 1030

 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 100/364 (27%), Positives = 138/364 (37%), Gaps = 37/364 (10%)

Query: 45  LEDEASYECQA----TQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRG 100
           L+D  +++C A    T    RS  A  ++      P VL  P+          +T R   
Sbjct: 93  LQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHI 152

Query: 101 DARPTPELLWFRDGV-LLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQ 159
           D  P P   WFRDG  L DG + H       T  S E  LTL P   +    + C A S 
Sbjct: 153 DGHPRPTYQWFRDGTPLSDGQSNH-------TVSSKERNLTLRPAGPEHSGLYSCCAHSA 205

Query: 160 ALPTGRDTAITLSL--QYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSP 217
                     TLS+  +    V L+     V   E+ +F CQ +AQPP +     +  +P
Sbjct: 206 FGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETP 265

Query: 218 VLGARGP----RLEVVADASFL---TEPVSCEVSNAVGSANRSTAL---DVLFGPILQAK 267
           +     P    R  V A+ S L     P +  +   +G   R   +     L    ++  
Sbjct: 266 ITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDM 325

Query: 268 P--EPVSVDVGEDASFSC-AWRGNPLPRVTWTRRG-----GAQVLGSGATLRLPSVGPED 319
           P  EP     G +   +C   +G P P V W   G       +V   G  L L ++   D
Sbjct: 326 PLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESD 385

Query: 320 AGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRG-PARLQCLVFASPAPD 378
           AG Y C A A L+G R    +  +TV   P             G P  L CL  A+P P 
Sbjct: 386 AGVYTCHA-ANLAGQR--RQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKP- 441

Query: 379 AVVW 382
            VVW
Sbjct: 442 TVVW 445



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 68/306 (22%), Positives = 114/306 (37%), Gaps = 67/306 (21%)

Query: 36  HDLHIRPVELEDEASYECQATQ-AGLRSRPAQLHVLVPPEAPQVLGGPSVS-LVAGVPAN 93
           H+L +  +   D   Y C A   AG R +   + V      P  L  P  S L  G P  
Sbjct: 374 HELVLANIAESDAGVYTCHAANLAGQRRQDVNITVAT---VPSWLKKPQDSQLEEGKPGY 430

Query: 94  LTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFV 153
           L C ++  A P P ++W+R+ +L+   +  + + K GT       L +      DG  + 
Sbjct: 431 LDCLTQ--ATPKPTVVWYRNQMLISEDSRFE-VFKNGT-------LRINSVEVYDGTWYR 480

Query: 154 CRARSQALPTGRDTAITLSLQYPPEVTL---SASPHTVQEGEKVIFLCQATAQPPVTGYR 210
           C + +   P G       S++    V +   S+ P  V +    +   + T        R
Sbjct: 481 CMSST---PAG-------SIEAQARVQVLDGSSLPEWVTDNAGTLHFARVT--------R 522

Query: 211 WAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEP 270
              G    + + GP+ ++ A                      + A+ + F    + +PE 
Sbjct: 523 DDAGNYTCIASNGPQGQIRAHVQL------------------TVAVFITF----KVEPER 560

Query: 271 VSVDVGEDASFSCAWRGNPLPRVTW---------TRRGGAQVLGSGATLRLPSVGPEDAG 321
            +V  G  A   C  +G+P P + W         T+ G    +    +L +  V PED+G
Sbjct: 561 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 620

Query: 322 DYVCRA 327
            Y C A
Sbjct: 621 RYTCIA 626



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 79/341 (23%), Positives = 114/341 (33%), Gaps = 32/341 (9%)

Query: 21  GWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQA---GLRSRPAQLHVLVPPEAPQ 77
           G S + +S    N    L +RP   E    Y C A  A      S+   L +     A  
Sbjct: 172 GQSNHTVSSKERN----LTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARV 227

Query: 78  VLGGPSVSLVAGVPANLTCRSRGDARPTPELLW-FRDGVLLDGATFHQTLLKEGTPGSVE 136
           VL    V +     A   C+    A+P P L W F D   +   +    L +        
Sbjct: 228 VLAPQDVVVARYEEAMFHCQF--SAQPPPSLQWLFEDETPITNRSRPPHLRRATV--FAN 283

Query: 137 STLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIF 196
            +L LT     +   + C  + Q  P     A TL L    ++ L   P     G +   
Sbjct: 284 GSLLLTQVRPRNAGIYRCIGQGQRGPPIILEA-TLHLAEIEDMPLF-EPRVFTAGSEERV 341

Query: 197 LCQATAQPPVTGYRWAKGGS--PVLGA---RGPRLEVVADASFLTEPVSCEVSNAVGSAN 251
            C      P     W   G   P  G    +G  L +   A       +C  +N  G   
Sbjct: 342 TCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRR 401

Query: 252 RSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRR-------GGAQVL 304
           +   + V   P    KP+   ++ G+     C  +  P P V W R           +V 
Sbjct: 402 QDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVF 461

Query: 305 GSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTV 345
            +G TLR+ SV   D   Y C     +S    G+ EA+  V
Sbjct: 462 KNG-TLRINSVEVYDGTWYRC-----MSSTPAGSIEAQARV 496


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,356,417
Number of Sequences: 37866
Number of extensions: 1384043
Number of successful extensions: 7243
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 221
Number of HSP's that attempted gapping in prelim test: 4220
Number of HSP's gapped (non-prelim): 1845
length of query: 583
length of database: 18,247,518
effective HSP length: 108
effective length of query: 475
effective length of database: 14,157,990
effective search space: 6725045250
effective search space used: 6725045250
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.