Search of human proteins with 109638745

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109638745 transforming growth factor beta 1 induced
transcript 1 isoform 1 [Homo sapiens]
         (461 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109638745 transforming growth factor beta 1 induced transcrip...   986   0.0  
gi|21361591 transforming growth factor beta 1 induced transcript...   954   0.0  
gi|170932516 paxillin isoform 2 [Homo sapiens]                        441   e-124
gi|170932514 paxillin isoform 1 [Homo sapiens]                        440   e-123
gi|170932518 paxillin isoform 3 [Homo sapiens]                        419   e-117
gi|4758670 leupaxin isoform 2 [Homo sapiens]                          377   e-105
gi|221316659 leupaxin isoform 1 [Homo sapiens]                        374   e-103
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]            172   6e-43
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]             172   6e-43
gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]            169   4e-42
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]            169   4e-42
gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]             167   2e-41
gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]             165   9e-41
gi|238859658 LIM and senescent cell antigen-like domains 2 isofo...   136   3e-32
gi|238776788 LIM and senescent cell antigen-like domains 2 isofo...   136   3e-32
gi|238776786 LIM and senescent cell antigen-like domains 2 isofo...   136   3e-32
gi|40804748 LIM and senescent cell antigen-like domains 2 isofor...   136   3e-32
gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo ...   135   6e-32
gi|58530845 zyxin [Homo sapiens]                                      122   7e-28
gi|4508047 zyxin [Homo sapiens]                                       122   7e-28
gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens]    121   1e-27
gi|54112385 four and a half LIM domains 3 [Homo sapiens]              120   3e-27
gi|7662330 actin binding LIM protein family, member 3 [Homo sapi...   115   1e-25
gi|51173715 actin-binding LIM protein 1 isoform c [Homo sapiens]      114   2e-25
gi|51173713 actin-binding LIM protein 1 isoform b [Homo sapiens]      114   2e-25
gi|51173711 actin-binding LIM protein 1 isoform a [Homo sapiens]      114   2e-25
gi|66932988 filamin-binding LIM protein-1 isoform c [Homo sapiens]    112   5e-25
gi|30410801 activator of cAMP-responsive element modulator (CREM...   112   5e-25
gi|87159836 four and a half LIM domains 2 [Homo sapiens]              112   9e-25
gi|87159834 four and a half LIM domains 2 [Homo sapiens]              112   9e-25

>gi|109638745 transforming growth factor beta 1 induced transcript 1
           isoform 1 [Homo sapiens]
          Length = 461

 Score =  986 bits (2549), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLY 60
           MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLY
Sbjct: 1   MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLY 60

Query: 61  STVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKV 120
           STVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKV
Sbjct: 61  STVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKV 120

Query: 121 ASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPT 180
           ASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPT
Sbjct: 121 ASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPT 180

Query: 181 QPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVV 240
           QPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVV
Sbjct: 181 QPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVV 240

Query: 241 TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVT 300
           TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVT
Sbjct: 241 TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVT 300

Query: 301 ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISA 360
           ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISA
Sbjct: 301 ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISA 360

Query: 361 LSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSAL 420
           LSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSAL
Sbjct: 361 LSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSAL 420

Query: 421 GRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG 461
           GRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
Sbjct: 421 GRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG 461


>gi|21361591 transforming growth factor beta 1 induced transcript 1
           isoform 2 [Homo sapiens]
          Length = 444

 Score =  954 bits (2465), Expect = 0.0
 Identities = 444/444 (100%), Positives = 444/444 (100%)

Query: 18  MPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAP 77
           MPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAP
Sbjct: 1   MPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAP 60

Query: 78  PFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPS 137
           PFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPS
Sbjct: 61  PFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPS 120

Query: 138 LPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPPE 197
           LPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPPE
Sbjct: 121 LPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPPE 180

Query: 198 PTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGC 257
           PTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGC
Sbjct: 181 PTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGC 240

Query: 258 STALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCG 317
           STALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCG
Sbjct: 241 STALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCG 300

Query: 318 EPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFA 377
           EPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFA
Sbjct: 301 EPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFA 360

Query: 378 PFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRP 437
           PFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRP
Sbjct: 361 PFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRP 420

Query: 438 LTKGSFQERAGKPYCQPCFLKLFG 461
           LTKGSFQERAGKPYCQPCFLKLFG
Sbjct: 421 LTKGSFQERAGKPYCQPCFLKLFG 444


>gi|170932516 paxillin isoform 2 [Homo sapiens]
          Length = 557

 Score =  441 bits (1134), Expect = e-124
 Identities = 250/576 (43%), Positives = 315/576 (54%), Gaps = 136/576 (23%)

Query: 1   MEDLDALLSDLETTTSHMPR------SGAPKERPA-----------EPLTPPPS------ 37
           M+DLDALL+DLE+TTSH+ +         P   P             P+ PPPS      
Sbjct: 1   MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNG 60

Query: 38  ---------------------------YGHQPQTGS--------GESSGASGDKDHLYST 62
                                      YG   +T S        G      G+++H+YS 
Sbjct: 61  TILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSF 120

Query: 63  VCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNI----TDEIMSQ---- 114
             K +S +P+    P   S+S  LG+ L ELDRLL ELNA Q N      DE  S     
Sbjct: 121 PNKQKSAEPS----PTVMSTS--LGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP 174

Query: 115 --------FPSSKVASGEQKEDQSEDKK-----------RPSLPS----------SPSPG 145
                    P +    G +    +++K            RPS+ S          SP P 
Sbjct: 175 GALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPA 234

Query: 146 LP-------------------KASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVS 186
           +                    + SA+SAT ELD LMASLSDF+      A G T      
Sbjct: 235 ITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFM----AQGKT------ 284

Query: 187 STNEGSPSPP--EPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALG 244
               GS SPP   P     LD+MLG LQSDL++ GV T AKG+CG+C KPIAGQVVTA+G
Sbjct: 285 ----GSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMG 340

Query: 245 RAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGT 304
           + WHPEHFVC  C   +G  +FFE+DG P+C + Y   FSPRC +CN PI  K+VTAL  
Sbjct: 341 KTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDR 400

Query: 305 HWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSAL 364
            WHPEHF C  CG  FG EGFHE++G+ YCR+D+  +FAP+C GC   IL+NYISAL+ L
Sbjct: 401 TWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTL 460

Query: 365 WHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRF 424
           WHP+CFVCRECF PF  GSFFEH+G+P CE H+H RRGSLC+ C  P+TGRC++A+ ++F
Sbjct: 461 WHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKF 520

Query: 425 HPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
           HP+HF C FCL+ L KG+F+E+  KPYCQ CFLKLF
Sbjct: 521 HPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 556


>gi|170932514 paxillin isoform 1 [Homo sapiens]
          Length = 591

 Score =  440 bits (1132), Expect = e-123
 Identities = 251/596 (42%), Positives = 319/596 (53%), Gaps = 142/596 (23%)

Query: 1   MEDLDALLSDLETTTSHMPR------SGAPKERPA-----------EPLTPPPS------ 37
           M+DLDALL+DLE+TTSH+ +         P   P             P+ PPPS      
Sbjct: 1   MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNG 60

Query: 38  ---------------------------YGHQPQTGS--------GESSGASGDKDHLYST 62
                                      YG   +T S        G      G+++H+YS 
Sbjct: 61  TILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSF 120

Query: 63  VCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNI----TDEIMSQ---- 114
             K +S +P+    P   S+S  LG+ L ELDRLL ELNA Q N      DE  S     
Sbjct: 121 PNKQKSAEPS----PTVMSTS--LGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLP 174

Query: 115 --------FPSSKVASGEQKEDQSEDKK-----------RPSLPS----------SPSPG 145
                    P +    G +    +++K            RPS+ S          SP P 
Sbjct: 175 GALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPA 234

Query: 146 LP-------------------KASATSATLELDRLMASLSDFRVQN-------------H 173
           +                    + SA+SAT ELD LMASLSDF++Q               
Sbjct: 235 ITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKIQGLEQRADGERCWAAG 294

Query: 174 LPASGPTQPP-------VVSSTNEGSPSPP--EPTGKGSLDTMLGLLQSDLSRRGVPTQA 224
            P  G    P        ++    GS SPP   P     LD+MLG LQSDL++ GV T A
Sbjct: 295 WPRDGGRSSPGGQDEGGFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVA 354

Query: 225 KGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFS 284
           KG+CG+C KPIAGQVVTA+G+ WHPEHFVC  C   +G  +FFE+DG P+C + Y   FS
Sbjct: 355 KGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFS 414

Query: 285 PRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAP 344
           PRC +CN PI  K+VTAL   WHPEHF C  CG  FG EGFHE++G+ YCR+D+  +FAP
Sbjct: 415 PRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAP 474

Query: 345 RCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSL 404
           +C GC   IL+NYISAL+ LWHP+CFVCRECF PF  GSFFEH+G+P CE H+H RRGSL
Sbjct: 475 KCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSL 534

Query: 405 CATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
           C+ C  P+TGRC++A+ ++FHP+HF C FCL+ L KG+F+E+  KPYCQ CFLKLF
Sbjct: 535 CSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 590


>gi|170932518 paxillin isoform 3 [Homo sapiens]
          Length = 424

 Score =  419 bits (1076), Expect = e-117
 Identities = 208/428 (48%), Positives = 265/428 (61%), Gaps = 32/428 (7%)

Query: 35  PPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELD 94
           PP +   P   +  S    G    LY     P +  P    A P +        G     
Sbjct: 26  PPGF---PADEANSSPPLPGALSPLYGV---PETNSPLGGKAGPLTKEKPKRNGG----- 74

Query: 95  RLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSA 154
           R L+++  +  ++ DE+ S  PS   A    + + S  ++  S          + SA+SA
Sbjct: 75  RGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQT-----RISASSA 129

Query: 155 TLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPP--EPTGKGSLDTMLGLLQ 212
           T ELD LMASLSDF+      A G T          GS SPP   P     LD+MLG LQ
Sbjct: 130 TRELDELMASLSDFKFM----AQGKT----------GSSSPPGGPPKPGSQLDSMLGSLQ 175

Query: 213 SDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGA 272
           SDL++ GV T AKG+CG+C KPIAGQVVTA+G+ WHPEHFVC  C   +G  +FFE+DG 
Sbjct: 176 SDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQ 235

Query: 273 PFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRP 332
           P+C + Y   FSPRC +CN PI  K+VTAL   WHPEHF C  CG  FG EGFHE++G+ 
Sbjct: 236 PYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKA 295

Query: 333 YCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPL 392
           YCR+D+  +FAP+C GC   IL+NYISAL+ LWHP+CFVCRECF PF  GSFFEH+G+P 
Sbjct: 296 YCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPY 355

Query: 393 CENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYC 452
           CE H+H RRGSLC+ C  P+TGRC++A+ ++FHP+HF C FCL+ L KG+F+E+  KPYC
Sbjct: 356 CEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYC 415

Query: 453 QPCFLKLF 460
           Q CFLKLF
Sbjct: 416 QNCFLKLF 423


>gi|4758670 leupaxin isoform 2 [Homo sapiens]
          Length = 386

 Score =  377 bits (969), Expect = e-105
 Identities = 180/394 (45%), Positives = 236/394 (59%), Gaps = 37/394 (9%)

Query: 92  ELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPSLPSSPSP------- 144
           ELD LL+EL  +    +DE  +  P        ++ +  E  +  S+  + SP       
Sbjct: 3   ELDALLEELERSTLQDSDEYSNPAPLPLDQHSRKETNLDETSEILSIQDNTSPLPAQLVY 62

Query: 145 -----------------GLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSS 187
                              P  S TSA  +LD LMA L++             Q  V   
Sbjct: 63  TTNIQELNVYSEAQEPKESPPPSKTSAAAQLDELMAHLTEM------------QAKVAVR 110

Query: 188 TNEGSPSPPEPTG-KGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRA 246
            + G    P+    K SLD+MLG L+ +L   G+ T  KG C SC KPIAG+V+ ALG++
Sbjct: 111 ADAGKKHLPDKQDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPIAGKVIHALGQS 170

Query: 247 WHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHW 306
           WHPEHFVC  C   +G S FFE+ G  +CP  Y + FSPRC +C  PI  K++TA+   W
Sbjct: 171 WHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTW 230

Query: 307 HPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWH 366
           HPEHF C  CGE FG EGFHE++ +PYCR+DFL +F+P+C GC  P+L+NY+SA+  +WH
Sbjct: 231 HPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMDTVWH 290

Query: 367 PDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHP 426
           P+CFVC +CF  FS GSFFE +GRP CE H+H RRG+LC  CG P+TGRC+SA+G +FHP
Sbjct: 291 PECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRCISAMGYKFHP 350

Query: 427 DHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
           +HF C FCL  L+KG F+E+  K YCQPCF KLF
Sbjct: 351 EHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 384


>gi|221316659 leupaxin isoform 1 [Homo sapiens]
          Length = 391

 Score =  374 bits (960), Expect = e-103
 Identities = 178/392 (45%), Positives = 234/392 (59%), Gaps = 37/392 (9%)

Query: 94  DRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPSLPSSPSP--------- 144
           D LL+EL  +    +DE  +  P        ++ +  E  +  S+  + SP         
Sbjct: 10  DALLEELERSTLQDSDEYSNPAPLPLDQHSRKETNLDETSEILSIQDNTSPLPAQLVYTT 69

Query: 145 ---------------GLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTN 189
                            P  S TSA  +LD LMA L++             Q  V    +
Sbjct: 70  NIQELNVYSEAQEPKESPPPSKTSAAAQLDELMAHLTEM------------QAKVAVRAD 117

Query: 190 EGSPSPPEPTG-KGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWH 248
            G    P+    K SLD+MLG L+ +L   G+ T  KG C SC KPIAG+V+ ALG++WH
Sbjct: 118 AGKKHLPDKQDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPIAGKVIHALGQSWH 177

Query: 249 PEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHP 308
           PEHFVC  C   +G S FFE+ G  +CP  Y + FSPRC +C  PI  K++TA+   WHP
Sbjct: 178 PEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTWHP 237

Query: 309 EHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPD 368
           EHF C  CGE FG EGFHE++ +PYCR+DFL +F+P+C GC  P+L+NY+SA+  +WHP+
Sbjct: 238 EHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMDTVWHPE 297

Query: 369 CFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDH 428
           CFVC +CF  FS GSFFE +GRP CE H+H RRG+LC  CG P+TGRC+SA+G +FHP+H
Sbjct: 298 CFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRCISAMGYKFHPEH 357

Query: 429 FTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
           F C FCL  L+KG F+E+  K YCQPCF KLF
Sbjct: 358 FVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 389


>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
          Length = 617

 Score =  172 bits (436), Expect = 6e-43
 Identities = 120/390 (30%), Positives = 165/390 (42%), Gaps = 52/390 (13%)

Query: 13  TTTSHMPRSGAPKERPAEPLTPPPS-YGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKP 71
           T+ S  P + APK R     +  PS Y   P +    S GA+      YS      SP P
Sbjct: 272 TSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGAN------YSPTPYTPSPAP 325

Query: 72  AAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKVA-SGEQKEDQS 130
           A   +P  + +   + T             A  +N         P+  VA SG   E  S
Sbjct: 326 AYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYN---------PAPSVAYSGGPAEPAS 376

Query: 131 EDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNE 190
               RP   +  S     A   S T        S+S    +  LP  GP   P       
Sbjct: 377 ----RPPWVTDDSFSQKFAPGKSTT--------SIS----KQTLPRGGPAYTPA------ 414

Query: 191 GSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPE 250
             P  P P  +G++           + R   +    LCG CN  I G  + A+GR+WHPE
Sbjct: 415 -GPQVP-PLARGTVQR---------AERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPE 463

Query: 251 HFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEH 310
            F C  C T+L    F E+    +C  CY + F+P C  CN  I  +++ AL   WH   
Sbjct: 464 EFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTC 523

Query: 311 FCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPIL--DNYISALSALWHPD 368
           F C +C +PFG+  FH  +G PYC +D++ LF+ +C GC  P+   D +I AL   WH  
Sbjct: 524 FVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDT 583

Query: 369 CFVCRECFAPFSGGSFFEHEGRPLCENHFH 398
           CF+C  C     G  F+  + RPLC+ H H
Sbjct: 584 CFICAVCHVNLEGQPFYSKKDRPLCKKHAH 613



 Score =  124 bits (312), Expect = 1e-28
 Identities = 60/172 (34%), Positives = 76/172 (44%), Gaps = 2/172 (1%)

Query: 284 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343
           +P CG CN  IR   + A+G  WHPE F C  C     D  F E +   YC R + Q FA
Sbjct: 438 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 497

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           P C  C   I+   + AL   WH  CFVC  C  PF    F   +G P CE  +     +
Sbjct: 498 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFST 557

Query: 404 LCATCGLPVTG--RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQ 453
            C  C  PV    + + ALG  +H   F C  C   L    F  +  +P C+
Sbjct: 558 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 609



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 34/117 (29%), Positives = 50/117 (42%)

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           P C  C   I   ++ A+   WHP+ F C  C    +   F E +    CE  +      
Sbjct: 439 PLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAP 498

Query: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
           LCA C   + G  + AL + +H   F C  C +P     F    G+PYC+  ++ LF
Sbjct: 499 LCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 555



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 21/60 (35%), Positives = 30/60 (50%)

Query: 401 RGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
           R  LC  C   + G  + A+GR +HP+ FTC +C   L    F E     YC+ C+ + F
Sbjct: 437 RTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFF 496


>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
          Length = 727

 Score =  172 bits (436), Expect = 6e-43
 Identities = 120/390 (30%), Positives = 165/390 (42%), Gaps = 52/390 (13%)

Query: 13  TTTSHMPRSGAPKERPAEPLTPPPS-YGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKP 71
           T+ S  P + APK R     +  PS Y   P +    S GA+      YS      SP P
Sbjct: 382 TSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGAN------YSPTPYTPSPAP 435

Query: 72  AAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKVA-SGEQKEDQS 130
           A   +P  + +   + T             A  +N         P+  VA SG   E  S
Sbjct: 436 AYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYN---------PAPSVAYSGGPAEPAS 486

Query: 131 EDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNE 190
               RP   +  S     A   S T        S+S    +  LP  GP   P       
Sbjct: 487 ----RPPWVTDDSFSQKFAPGKSTT--------SIS----KQTLPRGGPAYTPA------ 524

Query: 191 GSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPE 250
             P  P P  +G++           + R   +    LCG CN  I G  + A+GR+WHPE
Sbjct: 525 -GPQVP-PLARGTVQR---------AERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPE 573

Query: 251 HFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEH 310
            F C  C T+L    F E+    +C  CY + F+P C  CN  I  +++ AL   WH   
Sbjct: 574 EFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTC 633

Query: 311 FCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPIL--DNYISALSALWHPD 368
           F C +C +PFG+  FH  +G PYC +D++ LF+ +C GC  P+   D +I AL   WH  
Sbjct: 634 FVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDT 693

Query: 369 CFVCRECFAPFSGGSFFEHEGRPLCENHFH 398
           CF+C  C     G  F+  + RPLC+ H H
Sbjct: 694 CFICAVCHVNLEGQPFYSKKDRPLCKKHAH 723



 Score =  124 bits (312), Expect = 1e-28
 Identities = 60/172 (34%), Positives = 76/172 (44%), Gaps = 2/172 (1%)

Query: 284 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343
           +P CG CN  IR   + A+G  WHPE F C  C     D  F E +   YC R + Q FA
Sbjct: 548 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 607

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           P C  C   I+   + AL   WH  CFVC  C  PF    F   +G P CE  +     +
Sbjct: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFST 667

Query: 404 LCATCGLPVTG--RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQ 453
            C  C  PV    + + ALG  +H   F C  C   L    F  +  +P C+
Sbjct: 668 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 34/117 (29%), Positives = 50/117 (42%)

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           P C  C   I   ++ A+   WHP+ F C  C    +   F E +    CE  +      
Sbjct: 549 PLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAP 608

Query: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
           LCA C   + G  + AL + +H   F C  C +P     F    G+PYC+  ++ LF
Sbjct: 609 LCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 665



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 21/60 (35%), Positives = 30/60 (50%)

Query: 401 RGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
           R  LC  C   + G  + A+GR +HP+ FTC +C   L    F E     YC+ C+ + F
Sbjct: 547 RTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFF 606


>gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]
          Length = 487

 Score =  169 bits (429), Expect = 4e-42
 Identities = 97/298 (32%), Positives = 149/298 (50%), Gaps = 24/298 (8%)

Query: 126 KEDQSEDKKRPSLPSSPSPGLPKASATSATL--ELDRL------MASLSDFRVQNHLPAS 177
           KE ++++ K+ +    PSP L  + A++ ++   LD        + SL+       + ++
Sbjct: 187 KESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGST 246

Query: 178 GPTQPPVVSSTNEGSPSPPE----PTGKGSL---DTMLGLLQSD----LSRRG--VPTQA 224
           G  + P     N+G PS        T  GS+   ++ LG  Q      L +R   +P   
Sbjct: 247 GVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGK 306

Query: 225 KG-LCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERF 283
           +  +C  CN+ I G  + ALG++WHPE F C  C   +    F E+ GA +C  CY + F
Sbjct: 307 RTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFF 366

Query: 284 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343
           +P CG C + I  ++++AL   WH   F CV+CG+P  +  FH  +G PYC  D+  LF 
Sbjct: 367 APECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFG 426

Query: 344 PRCQGCQGPIL--DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHA 399
             C GC+ PI   D ++ AL   WH  CFVC  C     G +FF  + +PLC+ H H+
Sbjct: 427 TICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHS 484



 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 36/118 (30%), Positives = 51/118 (43%)

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           P C  C   I   ++ AL   WHP+ F C  C    +   F E +G   CE  +      
Sbjct: 309 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 368

Query: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG 461
            C  C   + G  +SAL + +H   F C  C +P+    F    G+PYC+  +  LFG
Sbjct: 369 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFG 426



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 21/61 (34%), Positives = 31/61 (50%)

Query: 400 RRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKL 459
           +R  +CA C   + G  + ALG+ +HP+ F C  C   +    F E  G  YC+ C+ K 
Sbjct: 306 KRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKF 365

Query: 460 F 460
           F
Sbjct: 366 F 366


>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
          Length = 596

 Score =  169 bits (429), Expect = 4e-42
 Identities = 97/298 (32%), Positives = 149/298 (50%), Gaps = 24/298 (8%)

Query: 126 KEDQSEDKKRPSLPSSPSPGLPKASATSATL--ELDRL------MASLSDFRVQNHLPAS 177
           KE ++++ K+ +    PSP L  + A++ ++   LD        + SL+       + ++
Sbjct: 296 KESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGST 355

Query: 178 GPTQPPVVSSTNEGSPSPPE----PTGKGSL---DTMLGLLQSD----LSRRG--VPTQA 224
           G  + P     N+G PS        T  GS+   ++ LG  Q      L +R   +P   
Sbjct: 356 GVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGK 415

Query: 225 KG-LCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERF 283
           +  +C  CN+ I G  + ALG++WHPE F C  C   +    F E+ GA +C  CY + F
Sbjct: 416 RTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFF 475

Query: 284 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343
           +P CG C + I  ++++AL   WH   F CV+CG+P  +  FH  +G PYC  D+  LF 
Sbjct: 476 APECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFG 535

Query: 344 PRCQGCQGPIL--DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHA 399
             C GC+ PI   D ++ AL   WH  CFVC  C     G +FF  + +PLC+ H H+
Sbjct: 536 TICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHS 593



 Score =  141 bits (355), Expect = 1e-33
 Identities = 132/499 (26%), Positives = 191/499 (38%), Gaps = 86/499 (17%)

Query: 13  TTTSHMPRSGAPK-----ERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPR 67
           T+T++M  + AP+       P     P PS    P                 ++T     
Sbjct: 118 TSTNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPA----------------HATTSSHA 161

Query: 68  SPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNA--TQFNI----TDEIMSQFPSSKVA 121
           SP P A   PP  ++SG+        D+    L+A  T  N+    T   +    S ++A
Sbjct: 162 SPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELA 221

Query: 122 SGEQKEDQSEDKKRPSLPS-------SPSPGLPKASATSATLELDRLMASLSDFRVQNHL 174
            G+++  Q + K++   P        +    +P  S  S      RL+    D+R     
Sbjct: 222 EGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKK----RLIEDTEDWR----- 272

Query: 175 PASGPTQPP---------------------VVSSTNEGSPSPPEPTGKGSLDTMLGLLQS 213
           P +G TQ                          + N   PSP   +   S  +M   L S
Sbjct: 273 PRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDS 332

Query: 214 DLSRR-GV----------PTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFV--CGGCSTA 260
             S R GV          P  + G+  S +     Q V + GR  +   +       ++A
Sbjct: 333 PTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSA 392

Query: 261 LGGSSFFEKDG----APFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSC 316
           LG +   ++D     A   P     + +P C  CNQ IR   + ALG  WHPE F C  C
Sbjct: 393 LGQTQPSDQDTLVQRAEHIPA---GKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHC 449

Query: 317 GEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECF 376
                  GF E +G  YC   + + FAP C  CQ  IL   ISAL   WH  CFVC  C 
Sbjct: 450 KNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACG 509

Query: 377 APFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTG--RCVSALGRRFHPDHFTCTFC 434
            P     F   +G P CE  ++A  G++C  C  P+      + ALG  +H   F C+ C
Sbjct: 510 KPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVC 569

Query: 435 LRPLTKGSFQERAGKPYCQ 453
              L   +F  +  KP C+
Sbjct: 570 CESLEGQTFFSKKDKPLCK 588



 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 36/118 (30%), Positives = 51/118 (43%)

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           P C  C   I   ++ AL   WHP+ F C  C    +   F E +G   CE  +      
Sbjct: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477

Query: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG 461
            C  C   + G  +SAL + +H   F C  C +P+    F    G+PYC+  +  LFG
Sbjct: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFG 535



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 21/61 (34%), Positives = 31/61 (50%)

Query: 400 RRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKL 459
           +R  +CA C   + G  + ALG+ +HP+ F C  C   +    F E  G  YC+ C+ K 
Sbjct: 415 KRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKF 474

Query: 460 F 460
           F
Sbjct: 475 F 475


>gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]
          Length = 457

 Score =  167 bits (422), Expect = 2e-41
 Identities = 114/387 (29%), Positives = 164/387 (42%), Gaps = 42/387 (10%)

Query: 26  ERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAPPFSSSSGV 85
           ++ + P   PP Y   P     +++   G      S     ++ +P  P  P  S    +
Sbjct: 92  QKASAPAADPPRYTFAPSVSLNKTARPFGAPPPADSA--PQQNGQPLRPLVPDASKQRLM 149

Query: 86  L---------GTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRP 136
                     GTG     R+L  L  T+F    +      SS+V   E     S      
Sbjct: 150 ENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPAS------ 203

Query: 137 SLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPP 196
           S P  P PG    S TS      R   ++     + + P    T       T    P+ P
Sbjct: 204 STPQEPWPGPTAPSPTS------RPPWAVDPAFAERYAPDKTSTV-----LTRHSQPATP 252

Query: 197 EPTGKGSLDTMLGLLQSDLSRRGVPTQAKG-----LCGSCNKPIAGQVVTALGRAWHPEH 251
            P     L +   ++Q+  +  GVP          +C  C+K I G+ + ALG A+HPE 
Sbjct: 253 TP-----LQSRTSIVQA--AAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEE 305

Query: 252 FVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHF 311
           FVC  C   L    FFE+ GA FCP CY  R++P C  C + I  +++ AL   WH   F
Sbjct: 306 FVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCF 365

Query: 312 CCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPI--LDNYISALSALWHPDC 369
            C +C  P  +  F+  EG PYC RD+ ++F  +C GC   I   D ++ AL   WH  C
Sbjct: 366 TCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTC 425

Query: 370 FVCRECFAPFSGGSFFEHEGRPLCENH 396
           FVC  C     G +F+  + RPLC++H
Sbjct: 426 FVCAICQINLEGKTFYSKKDRPLCKSH 452



 Score =  112 bits (280), Expect = 7e-25
 Identities = 55/172 (31%), Positives = 80/172 (46%), Gaps = 2/172 (1%)

Query: 284 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343
           +P C  C++ IR + + ALG  +HPE F C  CG+   + GF E +G  +C   +   +A
Sbjct: 279 TPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 338

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           P C  C+  I    + AL   WH  CF C  C  P    +F+  EG P CE  +    G+
Sbjct: 339 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGT 398

Query: 404 LCATCGLPVTG--RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQ 453
            C  C   +    R + ALG  +H   F C  C   L   +F  +  +P C+
Sbjct: 399 KCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 450



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 41/118 (34%), Positives = 55/118 (46%)

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           P C  C   I   Y+ AL   +HP+ FVC +C      G FFE +G   C   +  R   
Sbjct: 280 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 339

Query: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG 461
            CA C   +TG  + AL   +H   FTC  C  P+   +F    G PYC+  + K+FG
Sbjct: 340 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFG 397


>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
          Length = 423

 Score =  165 bits (417), Expect = 9e-41
 Identities = 103/317 (32%), Positives = 143/317 (45%), Gaps = 31/317 (9%)

Query: 87  GTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPSLPSSPSPGL 146
           GTG     R+L  L  T+F    +      SS+V   E     S      S P  P PG 
Sbjct: 126 GTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPAS------STPQEPWPGP 179

Query: 147 PKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPPEPTGKGSLDT 206
              S TS      R   ++     + + P    T       T    P+ P P     L +
Sbjct: 180 TAPSPTS------RPPWAVDPAFAERYAPDKTSTV-----LTRHSQPATPTP-----LQS 223

Query: 207 MLGLLQSDLSRRGVPTQAKG-----LCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTAL 261
              ++Q+  +  GVP          +C  C+K I G+ + ALG A+HPE FVC  C   L
Sbjct: 224 RTSIVQA--AAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVL 281

Query: 262 GGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFG 321
               FFE+ GA FCP CY  R++P C  C + I  +++ AL   WH   F C +C  P  
Sbjct: 282 EEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIR 341

Query: 322 DEGFHEREGRPYCRRDFLQLFAPRCQGCQGPI--LDNYISALSALWHPDCFVCRECFAPF 379
           +  F+  EG PYC RD+ ++F  +C GC   I   D ++ AL   WH  CFVC  C    
Sbjct: 342 NRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINL 401

Query: 380 SGGSFFEHEGRPLCENH 396
            G +F+  + RPLC++H
Sbjct: 402 EGKTFYSKKDRPLCKSH 418



 Score =  112 bits (280), Expect = 7e-25
 Identities = 55/172 (31%), Positives = 80/172 (46%), Gaps = 2/172 (1%)

Query: 284 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343
           +P C  C++ IR + + ALG  +HPE F C  CG+   + GF E +G  +C   +   +A
Sbjct: 245 TPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           P C  C+  I    + AL   WH  CF C  C  P    +F+  EG P CE  +    G+
Sbjct: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGT 364

Query: 404 LCATCGLPVTG--RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQ 453
            C  C   +    R + ALG  +H   F C  C   L   +F  +  +P C+
Sbjct: 365 KCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 41/118 (34%), Positives = 55/118 (46%)

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           P C  C   I   Y+ AL   +HP+ FVC +C      G FFE +G   C   +  R   
Sbjct: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305

Query: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG 461
            CA C   +TG  + AL   +H   FTC  C  P+   +F    G PYC+  + K+FG
Sbjct: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFG 363


>gi|238859658 LIM and senescent cell antigen-like domains 2 isoform
           1 [Homo sapiens]
          Length = 363

 Score =  136 bits (343), Expect = 3e-32
 Identities = 76/237 (32%), Positives = 109/237 (45%), Gaps = 7/237 (2%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPR- 286
           CGSC + I G+V+ A+   WHP  F C  C   L    F +  G   C  C+    +   
Sbjct: 98  CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGL 157

Query: 287 ----CGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLF 342
               C  C+  I  + +      +HP+HF C  CG+    E   E +G  YC     ++ 
Sbjct: 158 GKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPCHDKMG 216

Query: 343 APRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRG 402
            P C  C+ PI    ++AL   WH + FVC +C  PF G   +E +G   CE H++   G
Sbjct: 217 VPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 276

Query: 403 SLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLT-KGSFQERAGKPYCQPCFLK 458
            +C  C   + G  VSAL + +    F+C+ C   LT K  F E   KP C+ C+ K
Sbjct: 277 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 333



 Score =  120 bits (302), Expect = 2e-27
 Identities = 72/245 (29%), Positives = 107/245 (43%), Gaps = 8/245 (3%)

Query: 224 AKGLCGSCNKPI--AGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFE 281
           A  +C  C      A ++V + G  +H   FVC  C        F+E +G  +C   +  
Sbjct: 33  ANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQM 92

Query: 282 RFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYC-----RR 336
            F+P CG C + I  +++ A+  +WHP  F C  C     D GF +  GR  C     R 
Sbjct: 93  LFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNRE 152

Query: 337 DFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENH 396
               L    CQ C   I +  +   S  +HPD F C  C    +  +  E +G   C   
Sbjct: 153 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPC 211

Query: 397 FHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456
                  +C  C  P+ GR V+ALG+++H +HF C  C +P       E+ G  YC+  +
Sbjct: 212 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 271

Query: 457 LKLFG 461
            +LFG
Sbjct: 272 NQLFG 276



 Score =  115 bits (288), Expect = 8e-26
 Identities = 61/177 (34%), Positives = 87/177 (49%), Gaps = 6/177 (3%)

Query: 223 QAKGL----CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPEC 278
           +AKGL    C  C+  I  Q +     A+HP+HF C  C   L   +  E  G  +C  C
Sbjct: 153 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPC 211

Query: 279 YFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDF 338
           + +   P CG C +PI  ++V ALG  WH EHF C  C +PF     +E++G  YC   +
Sbjct: 212 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 271

Query: 339 LQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFS-GGSFFEHEGRPLCE 394
            QLF   C  C   I  + +SAL+  W   CF C  C +  +    F E + +P+C+
Sbjct: 272 NQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 328



 Score =  114 bits (284), Expect = 2e-25
 Identities = 67/207 (32%), Positives = 93/207 (44%), Gaps = 16/207 (7%)

Query: 258 STALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCG 317
           + AL  S+  +      C  C   RFSP           ++V + G  +H   F C  C 
Sbjct: 20  AAALRWSNMSDALANAVCQRCQ-ARFSPA---------ERIVNSNGELYHEHCFVCAQCF 69

Query: 318 EPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFA 377
            PF +  F+E EGR YC  DF  LFAP C  C   I+   I A++  WHP CF C  C  
Sbjct: 70  RPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDV 129

Query: 378 PFSGGSFFEHEGRPLCENHFHARRGS-----LCATCGLPVTGRCVSALGRRFHPDHFTCT 432
             +   F ++ GR LC    +  +       +C  C L +  + +      +HPDHF CT
Sbjct: 130 ELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCT 189

Query: 433 FCLRPLTKGSFQERAGKPYCQPCFLKL 459
            C + LT    +E  G+ YC PC  K+
Sbjct: 190 HCGKELT-AEARELKGELYCLPCHDKM 215


>gi|238776788 LIM and senescent cell antigen-like domains 2 isoform
           5 [Homo sapiens]
          Length = 336

 Score =  136 bits (343), Expect = 3e-32
 Identities = 76/237 (32%), Positives = 109/237 (45%), Gaps = 7/237 (2%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPR- 286
           CGSC + I G+V+ A+   WHP  F C  C   L    F +  G   C  C+    +   
Sbjct: 71  CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGL 130

Query: 287 ----CGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLF 342
               C  C+  I  + +      +HP+HF C  CG+    E   E +G  YC     ++ 
Sbjct: 131 GKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPCHDKMG 189

Query: 343 APRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRG 402
            P C  C+ PI    ++AL   WH + FVC +C  PF G   +E +G   CE H++   G
Sbjct: 190 VPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 249

Query: 403 SLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLT-KGSFQERAGKPYCQPCFLK 458
            +C  C   + G  VSAL + +    F+C+ C   LT K  F E   KP C+ C+ K
Sbjct: 250 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 306



 Score =  120 bits (302), Expect = 2e-27
 Identities = 72/245 (29%), Positives = 107/245 (43%), Gaps = 8/245 (3%)

Query: 224 AKGLCGSCNKPI--AGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFE 281
           A  +C  C      A ++V + G  +H   FVC  C        F+E +G  +C   +  
Sbjct: 6   ANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQM 65

Query: 282 RFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYC-----RR 336
            F+P CG C + I  +++ A+  +WHP  F C  C     D GF +  GR  C     R 
Sbjct: 66  LFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNRE 125

Query: 337 DFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENH 396
               L    CQ C   I +  +   S  +HPD F C  C    +  +  E +G   C   
Sbjct: 126 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPC 184

Query: 397 FHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456
                  +C  C  P+ GR V+ALG+++H +HF C  C +P       E+ G  YC+  +
Sbjct: 185 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 244

Query: 457 LKLFG 461
            +LFG
Sbjct: 245 NQLFG 249



 Score =  115 bits (288), Expect = 8e-26
 Identities = 61/177 (34%), Positives = 87/177 (49%), Gaps = 6/177 (3%)

Query: 223 QAKGL----CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPEC 278
           +AKGL    C  C+  I  Q +     A+HP+HF C  C   L   +  E  G  +C  C
Sbjct: 126 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPC 184

Query: 279 YFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDF 338
           + +   P CG C +PI  ++V ALG  WH EHF C  C +PF     +E++G  YC   +
Sbjct: 185 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 244

Query: 339 LQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFS-GGSFFEHEGRPLCE 394
            QLF   C  C   I  + +SAL+  W   CF C  C +  +    F E + +P+C+
Sbjct: 245 NQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 301


>gi|238776786 LIM and senescent cell antigen-like domains 2 isoform
           3 [Homo sapiens]
          Length = 341

 Score =  136 bits (343), Expect = 3e-32
 Identities = 76/237 (32%), Positives = 109/237 (45%), Gaps = 7/237 (2%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPR- 286
           CGSC + I G+V+ A+   WHP  F C  C   L    F +  G   C  C+    +   
Sbjct: 76  CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGL 135

Query: 287 ----CGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLF 342
               C  C+  I  + +      +HP+HF C  CG+    E   E +G  YC     ++ 
Sbjct: 136 GKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPCHDKMG 194

Query: 343 APRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRG 402
            P C  C+ PI    ++AL   WH + FVC +C  PF G   +E +G   CE H++   G
Sbjct: 195 VPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 254

Query: 403 SLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLT-KGSFQERAGKPYCQPCFLK 458
            +C  C   + G  VSAL + +    F+C+ C   LT K  F E   KP C+ C+ K
Sbjct: 255 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 311



 Score =  120 bits (302), Expect = 2e-27
 Identities = 72/245 (29%), Positives = 107/245 (43%), Gaps = 8/245 (3%)

Query: 224 AKGLCGSCNKPI--AGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFE 281
           A  +C  C      A ++V + G  +H   FVC  C        F+E +G  +C   +  
Sbjct: 11  ANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQM 70

Query: 282 RFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYC-----RR 336
            F+P CG C + I  +++ A+  +WHP  F C  C     D GF +  GR  C     R 
Sbjct: 71  LFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNRE 130

Query: 337 DFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENH 396
               L    CQ C   I +  +   S  +HPD F C  C    +  +  E +G   C   
Sbjct: 131 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPC 189

Query: 397 FHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456
                  +C  C  P+ GR V+ALG+++H +HF C  C +P       E+ G  YC+  +
Sbjct: 190 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 249

Query: 457 LKLFG 461
            +LFG
Sbjct: 250 NQLFG 254



 Score =  115 bits (288), Expect = 8e-26
 Identities = 61/177 (34%), Positives = 87/177 (49%), Gaps = 6/177 (3%)

Query: 223 QAKGL----CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPEC 278
           +AKGL    C  C+  I  Q +     A+HP+HF C  C   L   +  E  G  +C  C
Sbjct: 131 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPC 189

Query: 279 YFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDF 338
           + +   P CG C +PI  ++V ALG  WH EHF C  C +PF     +E++G  YC   +
Sbjct: 190 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 249

Query: 339 LQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFS-GGSFFEHEGRPLCE 394
            QLF   C  C   I  + +SAL+  W   CF C  C +  +    F E + +P+C+
Sbjct: 250 NQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 306



 Score =  114 bits (285), Expect = 2e-25
 Identities = 66/202 (32%), Positives = 91/202 (45%), Gaps = 16/202 (7%)

Query: 263 GSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGD 322
           GS+  +      C  C   RFSP           ++V + G  +H   F C  C  PF +
Sbjct: 3   GSNMSDALANAVCQRCQ-ARFSPA---------ERIVNSNGELYHEHCFVCAQCFRPFPE 52

Query: 323 EGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGG 382
             F+E EGR YC  DF  LFAP C  C   I+   I A++  WHP CF C  C    +  
Sbjct: 53  GLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADL 112

Query: 383 SFFEHEGRPLCENHFHARRGS-----LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRP 437
            F ++ GR LC    +  +       +C  C L +  + +      +HPDHF CT C + 
Sbjct: 113 GFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKE 172

Query: 438 LTKGSFQERAGKPYCQPCFLKL 459
           LT    +E  G+ YC PC  K+
Sbjct: 173 LT-AEARELKGELYCLPCHDKM 193


>gi|40804748 LIM and senescent cell antigen-like domains 2 isoform 2
           [Homo sapiens]
          Length = 365

 Score =  136 bits (343), Expect = 3e-32
 Identities = 76/237 (32%), Positives = 109/237 (45%), Gaps = 7/237 (2%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPR- 286
           CGSC + I G+V+ A+   WHP  F C  C   L    F +  G   C  C+    +   
Sbjct: 100 CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGL 159

Query: 287 ----CGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLF 342
               C  C+  I  + +      +HP+HF C  CG+    E   E +G  YC     ++ 
Sbjct: 160 GKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPCHDKMG 218

Query: 343 APRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRG 402
            P C  C+ PI    ++AL   WH + FVC +C  PF G   +E +G   CE H++   G
Sbjct: 219 VPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 278

Query: 403 SLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLT-KGSFQERAGKPYCQPCFLK 458
            +C  C   + G  VSAL + +    F+C+ C   LT K  F E   KP C+ C+ K
Sbjct: 279 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335



 Score =  120 bits (302), Expect = 2e-27
 Identities = 72/245 (29%), Positives = 107/245 (43%), Gaps = 8/245 (3%)

Query: 224 AKGLCGSCNKPI--AGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFE 281
           A  +C  C      A ++V + G  +H   FVC  C        F+E +G  +C   +  
Sbjct: 35  ANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQM 94

Query: 282 RFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYC-----RR 336
            F+P CG C + I  +++ A+  +WHP  F C  C     D GF +  GR  C     R 
Sbjct: 95  LFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNRE 154

Query: 337 DFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENH 396
               L    CQ C   I +  +   S  +HPD F C  C    +  +  E +G   C   
Sbjct: 155 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPC 213

Query: 397 FHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456
                  +C  C  P+ GR V+ALG+++H +HF C  C +P       E+ G  YC+  +
Sbjct: 214 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 273

Query: 457 LKLFG 461
            +LFG
Sbjct: 274 NQLFG 278



 Score =  115 bits (288), Expect = 8e-26
 Identities = 61/177 (34%), Positives = 87/177 (49%), Gaps = 6/177 (3%)

Query: 223 QAKGL----CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPEC 278
           +AKGL    C  C+  I  Q +     A+HP+HF C  C   L   +  E  G  +C  C
Sbjct: 155 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPC 213

Query: 279 YFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDF 338
           + +   P CG C +PI  ++V ALG  WH EHF C  C +PF     +E++G  YC   +
Sbjct: 214 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 273

Query: 339 LQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFS-GGSFFEHEGRPLCE 394
            QLF   C  C   I  + +SAL+  W   CF C  C +  +    F E + +P+C+
Sbjct: 274 NQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 330


>gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo
           sapiens]
          Length = 325

 Score =  135 bits (341), Expect = 6e-32
 Identities = 75/238 (31%), Positives = 111/238 (46%), Gaps = 9/238 (3%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPR- 286
           C  C + I G+V+ A+  +WHPE F C  C   L    F +  G   C  C+  R   R 
Sbjct: 71  CHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCH-NREKARG 129

Query: 287 -----CGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQL 341
                C  C+  I  + +      +HP+HF C +CG+    +   E +G  YC     ++
Sbjct: 130 LGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADA-RELKGELYCLPCHDKM 188

Query: 342 FAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARR 401
             P C  C+ PI    ++A+   WH + FVC +C  PF G   +E +G   CE H++   
Sbjct: 189 GVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLF 248

Query: 402 GSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLT-KGSFQERAGKPYCQPCFLK 458
           G +C  C   + G  VSAL + +  + F C+ C   LT K  F E   KP C+ C+ K
Sbjct: 249 GDVCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEK 306



 Score =  120 bits (300), Expect = 3e-27
 Identities = 72/245 (29%), Positives = 107/245 (43%), Gaps = 8/245 (3%)

Query: 224 AKGLCGSCNKPIAG--QVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFE 281
           A   C  C    A   ++V + G  +H + FVC  C        F+E +G  +C   +  
Sbjct: 6   ASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQM 65

Query: 282 RFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYC-----RR 336
            F+P C  C + I  +++ A+   WHPE F C  C E   D GF +  GR  C     R 
Sbjct: 66  LFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNRE 125

Query: 337 DFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENH 396
               L    CQ C   I +  +   +  +HPD F C  C    +  +  E +G   C   
Sbjct: 126 KARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADA-RELKGELYCLPC 184

Query: 397 FHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456
                  +C  C  P+ GR V+A+G+++H +HF C  C +P       ER G  YC+  +
Sbjct: 185 HDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHY 244

Query: 457 LKLFG 461
            +LFG
Sbjct: 245 NQLFG 249



 Score =  114 bits (286), Expect = 1e-25
 Identities = 57/171 (33%), Positives = 83/171 (48%), Gaps = 2/171 (1%)

Query: 225 KGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFS 284
           K +C  C+  I  Q +      +HP+HF C  C   L   +  E  G  +C  C+ +   
Sbjct: 132 KYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADAR-ELKGELYCLPCHDKMGV 190

Query: 285 PRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAP 344
           P CG C +PI  ++V A+G  WH EHF C  C +PF     +ER+G  YC   + QLF  
Sbjct: 191 PICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGD 250

Query: 345 RCQGCQGPILDNYISALSALWHPDCFVCRECFAPFS-GGSFFEHEGRPLCE 394
            C  C   I  + +SAL+  W  +CF C  C    +    F E + +P+C+
Sbjct: 251 VCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCK 301



 Score = 89.0 bits (219), Expect = 8e-18
 Identities = 40/117 (34%), Positives = 59/117 (50%), Gaps = 2/117 (1%)

Query: 341 LFAPRCQGCQGPIL--DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFH 398
           L +  C+ C+G     +  +++   L+H  CFVC +CF  F  G F+E EGR  CE+ F 
Sbjct: 5   LASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQ 64

Query: 399 ARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPC 455
                 C  CG  + GR + A+   +HP+ F C  C   L    F + AG+  C+PC
Sbjct: 65  MLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPC 121


>gi|58530845 zyxin [Homo sapiens]
          Length = 572

 Score =  122 bits (306), Expect = 7e-28
 Identities = 84/302 (27%), Positives = 126/302 (41%), Gaps = 27/302 (8%)

Query: 117 SSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPA 176
           +SK + G      S+  ++   P + S G       S T    R    + +   + H   
Sbjct: 277 ASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQE---KQH--- 330

Query: 177 SGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQ----AKGLCGSCN 232
             P  PP  +     SP  P P     ++ +  L Q  +     P +       LCG C+
Sbjct: 331 --PVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCH 388

Query: 233 KPIAGQ--VVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFC 290
           +P+A     V ALG+ +H   F C  C+  L G  F+  +GAP+C  CY +    +C  C
Sbjct: 389 QPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE-KCNTC 447

Query: 291 NQPIRHKMVTALGTHWHPEHFCCVSCGEPF-GDEGFHEREGRPYCRRDFLQLFAPRCQGC 349
            +PI  +M+ A G  +HP  F CV C  P  G     ++  RP+C  D+ + +APRC  C
Sbjct: 448 GEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVC 507

Query: 350 QGPILDN-------YISALSALWHPDCFVCRECFAPFS----GGSFFEHEGRPLCENHFH 398
             PI+          + AL   +H  C+ C +C  P S        F  +G  LC     
Sbjct: 508 SEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHT 567

Query: 399 AR 400
           AR
Sbjct: 568 AR 569



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 53/163 (32%), Positives = 72/163 (44%), Gaps = 11/163 (6%)

Query: 287 CGFCNQPIRHKM--VTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAP 344
           CG C+QP+      V ALG  +H   F C  C +    + F+  EG PYC   +      
Sbjct: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE- 442

Query: 345 RCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFF-EHEGRPLCENHFHARRGS 403
           +C  C  PI D  + A    +HP CF C  C  P  G SF  +   RP C   +H +   
Sbjct: 443 KCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAP 502

Query: 404 LCATCGLPVT---GRC----VSALGRRFHPDHFTCTFCLRPLT 439
            C+ C  P+    GR     V AL + FH   + C  C +PL+
Sbjct: 503 RCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLS 545



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 43/118 (36%), Positives = 59/118 (50%), Gaps = 4/118 (3%)

Query: 346 CQGCQGPIL--DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           C  C  P+      + AL  L+H  CF C +C     G  F+  EG P CE  +      
Sbjct: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK 443

Query: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSF-QERAGKPYCQPCFLKLF 460
            C TCG P+T R + A G+ +HP  FTC  C RPL   SF  ++A +P+C P + K +
Sbjct: 444 -CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQY 500



 Score = 32.3 bits (72), Expect = 0.93
 Identities = 23/77 (29%), Positives = 33/77 (42%), Gaps = 4/77 (5%)

Query: 131 EDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPA---SGPTQPPVVSS 187
           E++  P  P  P P  P+   +S  LE+D L + L D    +   A   SG   PPV + 
Sbjct: 122 EEEGGPEAPIPPPPQ-PREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATP 180

Query: 188 TNEGSPSPPEPTGKGSL 204
            +  S + P   G   L
Sbjct: 181 FSSKSSTKPAAGGTAPL 197


>gi|4508047 zyxin [Homo sapiens]
          Length = 572

 Score =  122 bits (306), Expect = 7e-28
 Identities = 84/302 (27%), Positives = 126/302 (41%), Gaps = 27/302 (8%)

Query: 117 SSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPA 176
           +SK + G      S+  ++   P + S G       S T    R    + +   + H   
Sbjct: 277 ASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQE---KQH--- 330

Query: 177 SGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQ----AKGLCGSCN 232
             P  PP  +     SP  P P     ++ +  L Q  +     P +       LCG C+
Sbjct: 331 --PVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCH 388

Query: 233 KPIAGQ--VVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFC 290
           +P+A     V ALG+ +H   F C  C+  L G  F+  +GAP+C  CY +    +C  C
Sbjct: 389 QPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE-KCNTC 447

Query: 291 NQPIRHKMVTALGTHWHPEHFCCVSCGEPF-GDEGFHEREGRPYCRRDFLQLFAPRCQGC 349
            +PI  +M+ A G  +HP  F CV C  P  G     ++  RP+C  D+ + +APRC  C
Sbjct: 448 GEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVC 507

Query: 350 QGPILDN-------YISALSALWHPDCFVCRECFAPFS----GGSFFEHEGRPLCENHFH 398
             PI+          + AL   +H  C+ C +C  P S        F  +G  LC     
Sbjct: 508 SEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHT 567

Query: 399 AR 400
           AR
Sbjct: 568 AR 569



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 53/163 (32%), Positives = 72/163 (44%), Gaps = 11/163 (6%)

Query: 287 CGFCNQPIRHKM--VTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAP 344
           CG C+QP+      V ALG  +H   F C  C +    + F+  EG PYC   +      
Sbjct: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE- 442

Query: 345 RCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFF-EHEGRPLCENHFHARRGS 403
           +C  C  PI D  + A    +HP CF C  C  P  G SF  +   RP C   +H +   
Sbjct: 443 KCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAP 502

Query: 404 LCATCGLPVT---GRC----VSALGRRFHPDHFTCTFCLRPLT 439
            C+ C  P+    GR     V AL + FH   + C  C +PL+
Sbjct: 503 RCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLS 545



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 43/118 (36%), Positives = 59/118 (50%), Gaps = 4/118 (3%)

Query: 346 CQGCQGPIL--DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
           C  C  P+      + AL  L+H  CF C +C     G  F+  EG P CE  +      
Sbjct: 384 CGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEK 443

Query: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSF-QERAGKPYCQPCFLKLF 460
            C TCG P+T R + A G+ +HP  FTC  C RPL   SF  ++A +P+C P + K +
Sbjct: 444 -CNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQY 500



 Score = 32.3 bits (72), Expect = 0.93
 Identities = 23/77 (29%), Positives = 33/77 (42%), Gaps = 4/77 (5%)

Query: 131 EDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPA---SGPTQPPVVSS 187
           E++  P  P  P P  P+   +S  LE+D L + L D    +   A   SG   PPV + 
Sbjct: 122 EEEGGPEAPIPPPPQ-PREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATP 180

Query: 188 TNEGSPSPPEPTGKGSL 204
            +  S + P   G   L
Sbjct: 181 FSSKSSTKPAAGGTAPL 197


>gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens]
          Length = 373

 Score =  121 bits (304), Expect = 1e-27
 Identities = 78/249 (31%), Positives = 110/249 (44%), Gaps = 36/249 (14%)

Query: 138 LPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPT-QPPVVSSTNEGSPSPP 196
           LPS      P  ++  A LE       LS        PA GP+ QP  +    E  P PP
Sbjct: 115 LPSEEEAPAPMGASLIADLE----QLHLSPPPPPPQAPAEGPSVQPGPLRPMEEELPPPP 170

Query: 197 -EPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQ--VVTALGRAWHPEHFV 253
            EP  KG+                    +  +C  C+K ++ +   V A+ R +H + F 
Sbjct: 171 AEPVEKGA--------------------STDICAFCHKTVSPRELAVEAMKRQYHAQCFT 210

Query: 254 CGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCC 313
           C  C   L G SF++KDG P C  CY +    RCG C + +R  ++ ALG  +HP  F C
Sbjct: 211 CRTCRRQLAGQSFYQKDGRPLCEPCYQDTLE-RCGKCGEVVRDHIIRALGQAFHPSCFTC 269

Query: 314 VSCGEPFGDEGFH-EREGRPYCRRDFLQLFAPRCQGCQGPILDN------YISALSALWH 366
           V+C    GDE F    +   YC  DF + FAP C  C+ PI+         I  +   +H
Sbjct: 270 VTCARCIGDESFALGSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFH 329

Query: 367 PDCFVCREC 375
            +C+ C +C
Sbjct: 330 ENCYRCEDC 338



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 16/186 (8%)

Query: 287 CGFCNQPI--RHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAP 344
           C FC++ +  R   V A+   +H + F C +C      + F++++GRP C   + Q    
Sbjct: 183 CAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCY-QDTLE 241

Query: 345 RCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSF-FEHEGRPLCENHFHARRGS 403
           RC  C   + D+ I AL   +HP CF C  C       SF    +    C + F+ +   
Sbjct: 242 RCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYRKFAP 301

Query: 404 LCATCGLPVTGR------CVSALGRRFHPDHFTCTFC-----LRPLTKGSFQERAGKPYC 452
           +C+ C  P+  R       +  +GR FH + + C  C     + P  +G +       +C
Sbjct: 302 VCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDCRILLSVEPTDQGCYPLN-NHLFC 360

Query: 453 QPCFLK 458
           +PC +K
Sbjct: 361 KPCHVK 366



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 37/104 (35%), Positives = 50/104 (48%), Gaps = 2/104 (1%)

Query: 358 ISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCV 417
           + A+   +H  CF CR C    +G SF++ +GRPLCE  +       C  CG  V    +
Sbjct: 197 VEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTL-ERCGKCGEVVRDHII 255

Query: 418 SALGRRFHPDHFTCTFCLRPLTKGSFQ-ERAGKPYCQPCFLKLF 460
            ALG+ FHP  FTC  C R +   SF      + YC   F + F
Sbjct: 256 RALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYRKF 299



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 22/55 (40%), Positives = 32/55 (58%), Gaps = 2/55 (3%)

Query: 404 LCATCGLPVTGR--CVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456
           +CA C   V+ R   V A+ R++H   FTC  C R L   SF ++ G+P C+PC+
Sbjct: 182 ICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCY 236


>gi|54112385 four and a half LIM domains 3 [Homo sapiens]
          Length = 280

 Score =  120 bits (300), Expect = 3e-27
 Identities = 57/173 (32%), Positives = 80/173 (46%), Gaps = 6/173 (3%)

Query: 228 CGSCNKPI--AGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSP 285
           C +C + +    + +   G+ WH   F+C GC   LG  SF    GA +C  CY  +F+P
Sbjct: 101 CSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAP 160

Query: 286 RCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPR 345
           RC  C++ +    VT     WH E   C  C  P   + F  R+  PYC   F +LFAP+
Sbjct: 161 RCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAPK 220

Query: 346 CQGCQGPIL----DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCE 394
           C  C+ PI+      Y+S     WH +CF C  C     G  F     + LC+
Sbjct: 221 CSSCKRPIVGLGGGKYVSFEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQ 273



 Score =  110 bits (276), Expect = 2e-24
 Identities = 61/217 (28%), Positives = 87/217 (40%), Gaps = 6/217 (2%)

Query: 245 RAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIR--HKMVTAL 302
           R +H   F C  C  +L    F  +D    C +CY   FS +C  C + +    + +   
Sbjct: 59  RHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYG 118

Query: 303 GTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALS 362
           G  WH   F C  C +P G   F   +G  YC   +   FAPRC  C   +    ++   
Sbjct: 119 GQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRD 178

Query: 363 ALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVT----GRCVS 418
             WH +C VC  C  P +G  F   +  P C   F       C++C  P+     G+ VS
Sbjct: 179 QPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAPKCSSCKRPIVGLGGGKYVS 238

Query: 419 ALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPC 455
              R +H + F+C  C   L    F     +  CQ C
Sbjct: 239 FEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQGC 275



 Score =  109 bits (273), Expect = 5e-24
 Identities = 60/215 (27%), Positives = 87/215 (40%), Gaps = 4/215 (1%)

Query: 250 EHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRH--KMVTALGTHWH 307
           E F C  C+ +L G  + + D  P+C  CY   F+  C  C Q I H  + +     H+H
Sbjct: 3   ESFDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFH 62

Query: 308 PEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPIL--DNYISALSALW 365
              F C  C     DE F  ++    C   +   F+ +C  C   ++     +      W
Sbjct: 63  EGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYGGQTW 122

Query: 366 HPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFH 425
           H  CF+C  C  P    SF   +G   C   +  +    CA C   +T   V+   + +H
Sbjct: 123 HEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRDQPWH 182

Query: 426 PDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
            +   CT C  PL    F  R   PYC  CF +LF
Sbjct: 183 RECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELF 217



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 20/55 (36%), Positives = 24/55 (43%), Gaps = 4/55 (7%)

Query: 228 CGSCNKPIAG----QVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPEC 278
           C SC +PI G    + V+   R WH   F C  CST+L G  F        C  C
Sbjct: 221 CSSCKRPIVGLGGGKYVSFEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQGC 275


>gi|7662330 actin binding LIM protein family, member 3 [Homo
           sapiens]
          Length = 683

 Score =  115 bits (287), Expect = 1e-25
 Identities = 68/238 (28%), Positives = 102/238 (42%), Gaps = 12/238 (5%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRC 287
           C  C     G+VV      +H   F C  C   L  S FF K+    C + Y + +  RC
Sbjct: 23  CYRCGDTCKGEVVRVHNNHFHIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRC 82

Query: 288 GFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPF---------GDEGFHEREGRPYCRRDF 338
             C   I  ++++ALG  +HP+ F C  C +PF         G E   +   +       
Sbjct: 83  DSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMASSKP 142

Query: 339 LQLFAP-RCQGCQGPILDNY-ISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENH 396
           +++  P  C GC+  I     + AL   WH  CF C+ C    + G +   +G P CE+ 
Sbjct: 143 IKIRGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVILT-GEYISKDGVPYCESD 201

Query: 397 FHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQP 454
           +HA+ G  C TC   ++GR + A G+ +HP    C  C +  T+G      G     P
Sbjct: 202 YHAQFGIKCETCDRYISGRVLEAGGKHYHPTCARCVRCHQMFTEGEEMYLTGSEVWHP 259



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 56/187 (29%), Positives = 80/187 (42%), Gaps = 12/187 (6%)

Query: 286 RCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPR 345
           +C  C    + ++V     H+H   F C  CG      GF  +     C +D+ QL+  R
Sbjct: 22  QCYRCGDTCKGEVVRVHNNHFHIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTR 81

Query: 346 CQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRP-LCE---------N 395
           C  C+  I    ISAL   +HP CFVC  C  PF  G      G+  +C+          
Sbjct: 82  CDSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMASSK 141

Query: 396 HFHARRGSLCATCGLPVT-GRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQP 454
               R  S CA C   +  G+ + AL +++H   F C  C   LT G +  + G PYC+ 
Sbjct: 142 PIKIRGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVILT-GEYISKDGVPYCES 200

Query: 455 CFLKLFG 461
            +   FG
Sbjct: 201 DYHAQFG 207


>gi|51173715 actin-binding LIM protein 1 isoform c [Homo sapiens]
          Length = 746

 Score =  114 bits (284), Expect = 2e-25
 Identities = 68/237 (28%), Positives = 100/237 (42%), Gaps = 11/237 (4%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRC 287
           C  C +P  G+V+    + +H + F C  C   L    FF K+G   C   Y   +  RC
Sbjct: 39  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRC 98

Query: 288 GFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPF--GDE-GFHERE------GRPYCRRDF 338
             C + +  ++VTALG  +HP  F C  C  PF  GD   F+ R+       +P      
Sbjct: 99  HGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPK 158

Query: 339 LQLFAPRCQGCQGPILDNY-ISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHF 397
              F+  C GC   I +   + AL   WH  CF C+ C    + G +   +G P CE  +
Sbjct: 159 ETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLT-GEYISKDGAPYCEKDY 217

Query: 398 HARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQP 454
               G  C  C   +TG+ + A  + +HP    C+ C +  T+G      G     P
Sbjct: 218 QGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHP 274



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 54/185 (29%), Positives = 84/185 (45%), Gaps = 11/185 (5%)

Query: 287 CGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRC 346
           C  C +P + +++     H+H + F C  CG      GF  + G   C  D+ +++  RC
Sbjct: 39  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRC 98

Query: 347 QGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGR---------PLCENHF 397
            GC   +    ++AL   +HP+CF C  C  PF  G      GR         P+  +  
Sbjct: 99  HGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPK 158

Query: 398 HARRGSLCATCGLPV-TGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456
                S CA CG  +  G+ + AL +++H   F C  C + LT G +  + G PYC+  +
Sbjct: 159 ETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLT-GEYISKDGAPYCEKDY 217

Query: 457 LKLFG 461
             LFG
Sbjct: 218 QGLFG 222



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 49/180 (27%), Positives = 70/180 (38%), Gaps = 39/180 (21%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCS---------TALGGSSFFEKDGAPFCPEC 278
           C  C + + G+VVTALG+ +HP  F C  C          T  G     +    P     
Sbjct: 98  CHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSP 157

Query: 279 YFERFSPRCGFCNQPIRH-KMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRD 337
               FS  C  C + I++ + + AL   WH   F C SCG+    E +  ++G PYC +D
Sbjct: 158 KETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPYCEKD 216

Query: 338 FLQLFAPRCQGCQGPILDNYISAL----------------------------SALWHPDC 369
           +  LF  +C+ C   I    + A                             S +WHPDC
Sbjct: 217 YQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDC 276


>gi|51173713 actin-binding LIM protein 1 isoform b [Homo sapiens]
          Length = 718

 Score =  114 bits (284), Expect = 2e-25
 Identities = 68/237 (28%), Positives = 100/237 (42%), Gaps = 11/237 (4%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRC 287
           C  C +P  G+V+    + +H + F C  C   L    FF K+G   C   Y   +  RC
Sbjct: 39  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRC 98

Query: 288 GFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPF--GDE-GFHERE------GRPYCRRDF 338
             C + +  ++VTALG  +HP  F C  C  PF  GD   F+ R+       +P      
Sbjct: 99  HGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPK 158

Query: 339 LQLFAPRCQGCQGPILDNY-ISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHF 397
              F+  C GC   I +   + AL   WH  CF C+ C    + G +   +G P CE  +
Sbjct: 159 ETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLT-GEYISKDGAPYCEKDY 217

Query: 398 HARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQP 454
               G  C  C   +TG+ + A  + +HP    C+ C +  T+G      G     P
Sbjct: 218 QGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHP 274



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 54/185 (29%), Positives = 84/185 (45%), Gaps = 11/185 (5%)

Query: 287 CGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRC 346
           C  C +P + +++     H+H + F C  CG      GF  + G   C  D+ +++  RC
Sbjct: 39  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRC 98

Query: 347 QGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGR---------PLCENHF 397
            GC   +    ++AL   +HP+CF C  C  PF  G      GR         P+  +  
Sbjct: 99  HGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPK 158

Query: 398 HARRGSLCATCGLPV-TGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456
                S CA CG  +  G+ + AL +++H   F C  C + LT G +  + G PYC+  +
Sbjct: 159 ETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLT-GEYISKDGAPYCEKDY 217

Query: 457 LKLFG 461
             LFG
Sbjct: 218 QGLFG 222



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 49/180 (27%), Positives = 70/180 (38%), Gaps = 39/180 (21%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCS---------TALGGSSFFEKDGAPFCPEC 278
           C  C + + G+VVTALG+ +HP  F C  C          T  G     +    P     
Sbjct: 98  CHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSP 157

Query: 279 YFERFSPRCGFCNQPIRH-KMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRD 337
               FS  C  C + I++ + + AL   WH   F C SCG+    E +  ++G PYC +D
Sbjct: 158 KETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPYCEKD 216

Query: 338 FLQLFAPRCQGCQGPILDNYISAL----------------------------SALWHPDC 369
           +  LF  +C+ C   I    + A                             S +WHPDC
Sbjct: 217 YQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDC 276


>gi|51173711 actin-binding LIM protein 1 isoform a [Homo sapiens]
          Length = 778

 Score =  114 bits (284), Expect = 2e-25
 Identities = 68/237 (28%), Positives = 100/237 (42%), Gaps = 11/237 (4%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRC 287
           C  C +P  G+V+    + +H + F C  C   L    FF K+G   C   Y   +  RC
Sbjct: 99  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRC 158

Query: 288 GFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPF--GDE-GFHERE------GRPYCRRDF 338
             C + +  ++VTALG  +HP  F C  C  PF  GD   F+ R+       +P      
Sbjct: 159 HGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPK 218

Query: 339 LQLFAPRCQGCQGPILDNY-ISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHF 397
              F+  C GC   I +   + AL   WH  CF C+ C    + G +   +G P CE  +
Sbjct: 219 ETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLT-GEYISKDGAPYCEKDY 277

Query: 398 HARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQP 454
               G  C  C   +TG+ + A  + +HP    C+ C +  T+G      G     P
Sbjct: 278 QGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHP 334



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 54/185 (29%), Positives = 84/185 (45%), Gaps = 11/185 (5%)

Query: 287 CGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRC 346
           C  C +P + +++     H+H + F C  CG      GF  + G   C  D+ +++  RC
Sbjct: 99  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRC 158

Query: 347 QGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGR---------PLCENHF 397
            GC   +    ++AL   +HP+CF C  C  PF  G      GR         P+  +  
Sbjct: 159 HGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPK 218

Query: 398 HARRGSLCATCGLPV-TGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456
                S CA CG  +  G+ + AL +++H   F C  C + LT G +  + G PYC+  +
Sbjct: 219 ETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLT-GEYISKDGAPYCEKDY 277

Query: 457 LKLFG 461
             LFG
Sbjct: 278 QGLFG 282



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 49/180 (27%), Positives = 70/180 (38%), Gaps = 39/180 (21%)

Query: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCS---------TALGGSSFFEKDGAPFCPEC 278
           C  C + + G+VVTALG+ +HP  F C  C          T  G     +    P     
Sbjct: 158 CHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSP 217

Query: 279 YFERFSPRCGFCNQPIRH-KMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRD 337
               FS  C  C + I++ + + AL   WH   F C SCG+    E +  ++G PYC +D
Sbjct: 218 KETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPYCEKD 276

Query: 338 FLQLFAPRCQGCQGPILDNYISAL----------------------------SALWHPDC 369
           +  LF  +C+ C   I    + A                             S +WHPDC
Sbjct: 277 YQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDC 336


>gi|66932988 filamin-binding LIM protein-1 isoform c [Homo sapiens]
          Length = 276

 Score =  112 bits (281), Expect = 5e-25
 Identities = 55/158 (34%), Positives = 81/158 (51%), Gaps = 10/158 (6%)

Query: 227 LCGSCNKPIAGQ--VVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFS 284
           +C  C+K ++ +   V A+ R +H + F C  C   L G SF++KDG P C  CY +   
Sbjct: 85  ICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTLE 144

Query: 285 PRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFH-EREGRPYCRRDFLQLFA 343
            RCG C + +R  ++ ALG  +HP  F CV+C    GDE F    +   YC  DF + FA
Sbjct: 145 -RCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYRKFA 203

Query: 344 PRCQGCQGPILDN------YISALSALWHPDCFVCREC 375
           P C  C+ PI+         I  +   +H +C+ C +C
Sbjct: 204 PVCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDC 241



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 16/186 (8%)

Query: 287 CGFCNQPI--RHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAP 344
           C FC++ +  R   V A+   +H + F C +C      + F++++GRP C   + Q    
Sbjct: 86  CAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCY-QDTLE 144

Query: 345 RCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSF-FEHEGRPLCENHFHARRGS 403
           RC  C   + D+ I AL   +HP CF C  C       SF    +    C + F+ +   
Sbjct: 145 RCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYRKFAP 204

Query: 404 LCATCGLPVTGR------CVSALGRRFHPDHFTCTFC-----LRPLTKGSFQERAGKPYC 452
           +C+ C  P+  R       +  +GR FH + + C  C     + P  +G +       +C
Sbjct: 205 VCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDCRILLSVEPTDQGCYPLN-NHLFC 263

Query: 453 QPCFLK 458
           +PC +K
Sbjct: 264 KPCHVK 269



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 37/104 (35%), Positives = 50/104 (48%), Gaps = 2/104 (1%)

Query: 358 ISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCV 417
           + A+   +H  CF CR C    +G SF++ +GRPLCE  +       C  CG  V    +
Sbjct: 100 VEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTL-ERCGKCGEVVRDHII 158

Query: 418 SALGRRFHPDHFTCTFCLRPLTKGSFQ-ERAGKPYCQPCFLKLF 460
            ALG+ FHP  FTC  C R +   SF      + YC   F + F
Sbjct: 159 RALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYRKF 202



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 23/57 (40%), Positives = 33/57 (57%), Gaps = 2/57 (3%)

Query: 402 GSLCATCGLPVTGR--CVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456
           G +CA C   V+ R   V A+ R++H   FTC  C R L   SF ++ G+P C+PC+
Sbjct: 83  GDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCY 139


>gi|30410801 activator of cAMP-responsive element modulator (CREM)
           in testis [Homo sapiens]
          Length = 284

 Score =  112 bits (281), Expect = 5e-25
 Identities = 64/236 (27%), Positives = 96/236 (40%), Gaps = 8/236 (3%)

Query: 228 CGSCNKPIAGQV--VTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSP 285
           C  C KPI      +    R WH   F C  C+ +L    F  KD    C ECY    S 
Sbjct: 41  CEECKKPIESDSKDLCYKDRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSS 100

Query: 286 RCGFCNQPIR--HKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343
           +C  C + I    + +   G +WH   F C +C +P G +    +E   YC   F + FA
Sbjct: 101 KCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFA 160

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
             C  C+  I    I+    LWH +CF+C  C        F   +  P C + ++    +
Sbjct: 161 HYCNFCKKVITSGGITFCDQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCMDCYNHLYAN 220

Query: 404 LCATCGLPVTG----RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPC 455
            C  C  P++G    + +     ++H + F C  C   L    F  +  + +CQ C
Sbjct: 221 KCVACSKPISGLTGAKFICFQDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKC 276



 Score =  103 bits (258), Expect = 3e-22
 Identities = 56/214 (26%), Positives = 85/214 (39%), Gaps = 4/214 (1%)

Query: 251 HFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRH--KMVTALGTHWHP 308
           HF C  C+ +L G  +  KD +P+C  CY   FS  C  C +PI    K +     HWH 
Sbjct: 5   HFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHE 64

Query: 309 EHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPIL--DNYISALSALWH 366
             F C  C     ++ F  ++ R  C   +    + +C  C+  I+     +      WH
Sbjct: 65  GCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWH 124

Query: 367 PDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHP 426
             CFVC  C  P         E    C   F       C  C   +T   ++   + +H 
Sbjct: 125 ETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFCDQLWHK 184

Query: 427 DHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
           + F C+ C + L +  F  R   P+C  C+  L+
Sbjct: 185 ECFLCSGCRKDLCEEQFMSRDDYPFCMDCYNHLY 218


>gi|87159836 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  112 bits (279), Expect = 9e-25
 Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 8/236 (3%)

Query: 228 CGSCNKPIAGQV--VTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSP 285
           C  C KPI      ++   R WH   F C  C  +L    F  K+    C +CY   +S 
Sbjct: 40  CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSS 99

Query: 286 RCGFCNQPIRH--KMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343
           +C  C + I    + +   G+ WH   F C  C +P G + F  ++ + +C   + +  A
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
            +C  C+ PI    ++     WH +CFVC  C    SG  F   +    C N F      
Sbjct: 160 MQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAK 219

Query: 404 LCATCGLPVTG----RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPC 455
            CA C  P++G    + +S   R++H D F C  C   L    F        C  C
Sbjct: 220 KCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDC 275



 Score =  108 bits (269), Expect = 1e-23
 Identities = 57/215 (26%), Positives = 93/215 (43%), Gaps = 4/215 (1%)

Query: 250 EHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRH--KMVTALGTHWH 307
           E F C  C+ +L G  +  ++ +P+C  C+   F+  C  C +PI    K ++    HWH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 308 PEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNY--ISALSALW 365
              F C  C     D+ F  +E +  C   +   ++ +CQ C+  I+     +    + W
Sbjct: 63  EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122

Query: 366 HPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFH 425
           H  CF+C  C  P    SF   + +  C   +  +    C  C  P+T   V+   + +H
Sbjct: 123 HETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQPWH 182

Query: 426 PDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
            + F CT C + L+   F  R    YC  CF  L+
Sbjct: 183 KECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLY 217



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 22/103 (21%), Positives = 36/103 (34%), Gaps = 30/103 (29%)

Query: 227 LCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPR 286
           +C +C K ++GQ  TA                          +D   +C  C+ + ++ +
Sbjct: 187 VCTACRKQLSGQRFTA--------------------------RDDFAYCLNCFCDLYAKK 220

Query: 287 CGFCNQPIR----HKMVTALGTHWHPEHFCCVSCGEPFGDEGF 325
           C  C  PI      K ++     WH + F C  C       GF
Sbjct: 221 CAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGF 263


>gi|87159834 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  112 bits (279), Expect = 9e-25
 Identities = 65/236 (27%), Positives = 96/236 (40%), Gaps = 8/236 (3%)

Query: 228 CGSCNKPIAGQV--VTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSP 285
           C  C KPI      ++   R WH   F C  C  +L    F  K+    C +CY   +S 
Sbjct: 40  CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSS 99

Query: 286 RCGFCNQPIRH--KMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343
           +C  C + I    + +   G+ WH   F C  C +P G + F  ++ + +C   + +  A
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159

Query: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403
            +C  C+ PI    ++     WH +CFVC  C    SG  F   +    C N F      
Sbjct: 160 MQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAK 219

Query: 404 LCATCGLPVTG----RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPC 455
            CA C  P++G    + +S   R++H D F C  C   L    F        C  C
Sbjct: 220 KCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDC 275



 Score =  108 bits (269), Expect = 1e-23
 Identities = 57/215 (26%), Positives = 93/215 (43%), Gaps = 4/215 (1%)

Query: 250 EHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRH--KMVTALGTHWH 307
           E F C  C+ +L G  +  ++ +P+C  C+   F+  C  C +PI    K ++    HWH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 308 PEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNY--ISALSALW 365
              F C  C     D+ F  +E +  C   +   ++ +CQ C+  I+     +    + W
Sbjct: 63  EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122

Query: 366 HPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFH 425
           H  CF+C  C  P    SF   + +  C   +  +    C  C  P+T   V+   + +H
Sbjct: 123 HETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQPWH 182

Query: 426 PDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460
            + F CT C + L+   F  R    YC  CF  L+
Sbjct: 183 KECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLY 217



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 22/103 (21%), Positives = 36/103 (34%), Gaps = 30/103 (29%)

Query: 227 LCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPR 286
           +C +C K ++GQ  TA                          +D   +C  C+ + ++ +
Sbjct: 187 VCTACRKQLSGQRFTA--------------------------RDDFAYCLNCFCDLYAKK 220

Query: 287 CGFCNQPIR----HKMVTALGTHWHPEHFCCVSCGEPFGDEGF 325
           C  C  PI      K ++     WH + F C  C       GF
Sbjct: 221 CAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGF 263


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.446 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,539,606
Number of Sequences: 37866
Number of extensions: 1359735
Number of successful extensions: 10788
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 125
Number of HSP's successfully gapped in prelim test: 472
Number of HSP's that attempted gapping in prelim test: 8817
Number of HSP's gapped (non-prelim): 1889
length of query: 461
length of database: 18,247,518
effective HSP length: 106
effective length of query: 355
effective length of database: 14,233,722
effective search space: 5052971310
effective search space used: 5052971310
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.