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Search of human proteins with 10947135
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10947135 ATP-binding cassette, sub-family F, member 1
isoform b [Homo sapiens]
(807 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10947135 ATP-binding cassette, sub-family F, member 1 isoform... 1607 0.0
gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform... 1588 0.0
gi|148612853 ATP-binding cassette, sub-family F (GCN20), member ... 439 e-123
gi|27881506 ATP-binding cassette, sub-family F, member 2 isoform... 412 e-115
gi|10947137 ATP-binding cassette, sub-family F, member 2 isoform... 412 e-115
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 75 2e-13
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 71 4e-12
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 70 6e-12
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 62 2e-09
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 62 2e-09
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 61 4e-09
gi|104526627 triadin [Homo sapiens] 61 4e-09
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 61 5e-09
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 61 5e-09
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 61 5e-09
gi|4557509 cylicin 2 [Homo sapiens] 60 6e-09
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 60 6e-09
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 60 1e-08
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 60 1e-08
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 59 1e-08
gi|27734775 hypothetical protein LOC286499 [Homo sapiens] 59 1e-08
gi|148746195 trichohyalin [Homo sapiens] 59 2e-08
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 57 5e-08
gi|221219020 NYD-SP11 protein [Homo sapiens] 57 5e-08
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 57 5e-08
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 57 9e-08
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 57 9e-08
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 56 2e-07
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 56 2e-07
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 56 2e-07
>gi|10947135 ATP-binding cassette, sub-family F, member 1 isoform b
[Homo sapiens]
Length = 807
Score = 1607 bits (4161), Expect = 0.0
Identities = 807/807 (100%), Positives = 807/807 (100%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK
Sbjct: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP
Sbjct: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
Query: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE
Sbjct: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAAN 240
EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAAN
Sbjct: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAAN 240
Query: 241 AAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPN 300
AAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPN
Sbjct: 241 AAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPN 300
Query: 301 GKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQ 360
GKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQ
Sbjct: 301 GKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQ 360
Query: 361 GQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRM 420
GQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRM
Sbjct: 361 GQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRM 420
Query: 421 RVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDI 480
RVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDI
Sbjct: 421 RVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDI 480
Query: 481 IHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEA 540
IHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEA
Sbjct: 481 IHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEA 540
Query: 541 LTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQK 600
LTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQK
Sbjct: 541 LTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQK 600
Query: 601 PLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYA 660
PLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYA
Sbjct: 601 PLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYA 660
Query: 661 EQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELAC 720
EQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELAC
Sbjct: 661 EQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELAC 720
Query: 721 REPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVS 780
REPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVS
Sbjct: 721 REPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVS 780
Query: 781 QIDGDFEDYKREVLEALGEVMVSRPRE 807
QIDGDFEDYKREVLEALGEVMVSRPRE
Sbjct: 781 QIDGDFEDYKREVLEALGEVMVSRPRE 807
>gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform a
[Homo sapiens]
Length = 845
Score = 1588 bits (4112), Expect = 0.0
Identities = 807/845 (95%), Positives = 807/845 (95%), Gaps = 38/845 (4%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK
Sbjct: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP
Sbjct: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
Query: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE
Sbjct: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQ-------------- 226
EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQ
Sbjct: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEE 240
Query: 227 ------------------------MEYERQVASLKAANAAENDFSVSQAEMSSRQAMLEN 262
MEYERQVASLKAANAAENDFSVSQAEMSSRQAMLEN
Sbjct: 241 GGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLEN 300
Query: 263 ASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNI 322
ASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNI
Sbjct: 301 ASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNI 360
Query: 323 DVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELR 382
DVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELR
Sbjct: 361 DVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELR 420
Query: 383 ATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTN 442
ATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTN
Sbjct: 421 ATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTN 480
Query: 443 HLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMY 502
HLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMY
Sbjct: 481 HLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMY 540
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 562
QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE
Sbjct: 541 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 600
Query: 563 LLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPN 622
LLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPN
Sbjct: 601 LLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPN 660
Query: 623 GVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQ 682
GVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQ
Sbjct: 661 GVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQ 720
Query: 683 DARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDA 742
DARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDA
Sbjct: 721 DARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDA 780
Query: 743 LGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMV 802
LGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMV
Sbjct: 781 LGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMV 840
Query: 803 SRPRE 807
SRPRE
Sbjct: 841 SRPRE 845
>gi|148612853 ATP-binding cassette, sub-family F (GCN20), member 3
[Homo sapiens]
Length = 709
Score = 439 bits (1129), Expect = e-123
Identities = 248/602 (41%), Positives = 358/602 (59%), Gaps = 32/602 (5%)
Query: 207 IIKEKEPPKQGKEKAKKAE-----QMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLE 261
++K ++ +K +KAE + E + +LK +N + + + S +++ LE
Sbjct: 109 LLKREQSSTVNAKKLEKAEARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLE 168
Query: 262 NAS-----DIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRAL 316
++ D+++E F +S + L AD+ + GRRYGLVG NG GKTTLLK +A R+L
Sbjct: 169 SSGKNKSYDVRIENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSL 228
Query: 317 SIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQG--DDTAAERL 374
+P +I +L EQEV D+TPA+Q+VL +D+ R LL ER L Q+ G + + A L
Sbjct: 229 RVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAEL 288
Query: 375 EKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTL 434
++Y +L A A A+A ILAGLGF P+MQ +PT++FSGGWRMR++LARALF P L
Sbjct: 289 AEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDL 348
Query: 435 LMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGN 494
L+LDEPTN LD+ A++WL NYLQ W T+L+VSHD+ FL+ + TDIIHL +QRL YRG+
Sbjct: 349 LLLDEPTNMLDVRAILWLENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGD 408
Query: 495 YMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQD 554
+ TF K Q++ ++YE Q+ Q + + + R + R +Q
Sbjct: 409 FETFIKSKQERLLNQQREYEAQQ--------------QYRQHIQVFIDRFRYNANRASQV 454
Query: 555 EES----QEAPELLKRPKEYTVRFTFPDP-PPLSPPVLGLHGVTFGYQGQKPLFKNLDFG 609
+ ++ PEL KE V FPD SPP+L L V F Y + +F L
Sbjct: 455 QSKLKMLEKLPELKPVDKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVS 514
Query: 610 IDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETP 669
D++SRIC+VG NG GKST+L LL G L P G + LKIG+F+Q + EQL + +
Sbjct: 515 ADLESRICVVGENGAGKSTMLKLLLGDLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSA 574
Query: 670 TEYLQRGF-NLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLIL 728
E L R F P ++ R LGR+G+ + LSGGQK+RV FA++ P+ IL
Sbjct: 575 VELLARKFPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYIL 634
Query: 729 DEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFED 788
DEPTN+LD+E+I+ALG A+N ++G VI+VSHD R I +LWV E V++++G F+
Sbjct: 635 DEPTNHLDMETIEALGRALNNFRGGVILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQ 694
Query: 789 YK 790
Y+
Sbjct: 695 YR 696
Score = 67.8 bits (164), Expect = 4e-11
Identities = 61/226 (26%), Positives = 101/226 (44%), Gaps = 34/226 (15%)
Query: 280 LFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAV 339
L V+ADL R +VG NG GK+T+LK + + D P V
Sbjct: 511 LSVSADLE----SRICVVGENGAGKSTMLKLL--------------------LGDLAP-V 545
Query: 340 QAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAG 399
+ + A + LK+ + QL+ + +A E L + + E + R L
Sbjct: 546 RGIRHAH-RNLKIGYFSQHHVEQLDL-NVSAVELLARKFP-------GRPEEEYRHQLGR 596
Query: 400 LGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGW 459
G E+ RP SGG + RV+ A+ P +LDEPTNHLD+ + L L +
Sbjct: 597 YGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNF 656
Query: 460 RKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQK 505
R +++VSHD+ F+ VC ++ + + G + ++ + Q++
Sbjct: 657 RGGVILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQYRALLQEQ 702
Score = 65.1 bits (157), Expect = 3e-10
Identities = 77/323 (23%), Positives = 118/323 (36%), Gaps = 59/323 (18%)
Query: 511 KQYEKQEKKLKELKAGGKSTKQAEK---QTKEALTRKQQKCRRKNQDEESQEAPELLKRP 567
K+ EK E +LK K K++EK +T L ++ + +ES+ E +
Sbjct: 121 KKLEKAEARLK-----AKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRL--ESSGKN 173
Query: 568 KEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKS 627
K Y VR D V+FG + L D + R +VG NG+GK+
Sbjct: 174 KSYDVRIENFD-------------VSFG---DRVLLAGADVNLAWGRRYGLVGRNGLGKT 217
Query: 628 TLLLLLTGKL--TPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQ--- 682
TLL +L + P H + + G L + + L+R L Q
Sbjct: 218 TLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAA 277
Query: 683 ----------------------------DARKCLGRFGLESHAHTIQICKLSGGQKARVV 714
A L G + SGG + R+
Sbjct: 278 GRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLA 337
Query: 715 FAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVV 774
A PD+L+LDEPTN LD+ +I L + + ++VVSHD + + +
Sbjct: 338 LARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPSTILVVSHDRNFLNAIATDIIHL 397
Query: 775 EEQSVSQIDGDFEDYKREVLEAL 797
Q + GDFE + + E L
Sbjct: 398 HSQRLDGYRGDFETFIKSKQERL 420
>gi|27881506 ATP-binding cassette, sub-family F, member 2 isoform a
[Homo sapiens]
Length = 623
Score = 412 bits (1059), Expect = e-115
Identities = 239/626 (38%), Positives = 364/626 (58%), Gaps = 45/626 (7%)
Query: 196 LDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAEN----------- 244
L ++ K++E K ++ P++G E+ + E QVA AN E
Sbjct: 5 LAKKKAAKKKEAAKARQRPRKGHEENG---DVVTEPQVAEKNEANGRETTEVDLLTKELE 61
Query: 245 DFSVSQAEMSSRQAMLE---NASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNG 301
DF + +A + +L N++D+ + S++ HG+EL + L + +GRRYGL+G NG
Sbjct: 62 DFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNG 121
Query: 302 KGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQG 361
GK+ LL I R + IP +ID+ +E+ + + V+ DT+R L +E RL
Sbjct: 122 IGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLAH 181
Query: 362 QLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMR 421
+ D E+L ++YE L A AE +A RIL GLGF P MQ + + FSGGWRMR
Sbjct: 182 E-----DAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMR 236
Query: 422 VSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDII 481
V+LARALF+ P +L+LDEPTNHLDL+A +WL L+ +++ L++VSH Q FL+ VCT+II
Sbjct: 237 VALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNII 296
Query: 482 HLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELK------AGGKSTKQAEK 535
H+ ++L YY GNY + K + ++ +K++ ++ ++ +K G + +
Sbjct: 297 HMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQA 356
Query: 536 QTKEALTRKQQKCRRKNQDEESQEAPELLKR-PKEYTVRFTFPDPPPLSPPVLGLHGVTF 594
Q+KE +K A L +R + T+ F FP + PPV+ + V+F
Sbjct: 357 QSKEKTLQKMM-------------ASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSF 403
Query: 595 GYQGQKP-LFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIG 653
Y P ++ NL+FGID+D+R+ +VGPNG GKSTLL LLTG+L PT G +RK+ +KIG
Sbjct: 404 KYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIG 463
Query: 654 FFNQQYAEQLRMEETPTEYLQRGFN--LPYQDARKCLGRFGLESHAHTIQICKLSGGQKA 711
++Q EQL ++ +P EY+ + + ++ RK +GR+GL I LS GQK
Sbjct: 464 RYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKC 523
Query: 712 RVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQL 771
RV A LA + P +L LDEPTN+LDIE+IDAL +AINE++G +++VSHD RLI + ++
Sbjct: 524 RVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEI 583
Query: 772 WVVEEQSVSQIDGDFEDYKREVLEAL 797
WV E+Q++++ GD YK + L
Sbjct: 584 WVCEKQTITKWPGDILAYKEHLKSKL 609
>gi|10947137 ATP-binding cassette, sub-family F, member 2 isoform b
[Homo sapiens]
Length = 634
Score = 412 bits (1059), Expect = e-115
Identities = 239/626 (38%), Positives = 364/626 (58%), Gaps = 45/626 (7%)
Query: 196 LDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAEN----------- 244
L ++ K++E K ++ P++G E+ + E QVA AN E
Sbjct: 5 LAKKKAAKKKEAAKARQRPRKGHEENG---DVVTEPQVAEKNEANGRETTEVDLLTKELE 61
Query: 245 DFSVSQAEMSSRQAMLE---NASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNG 301
DF + +A + +L N++D+ + S++ HG+EL + L + +GRRYGL+G NG
Sbjct: 62 DFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNG 121
Query: 302 KGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQG 361
GK+ LL I R + IP +ID+ +E+ + + V+ DT+R L +E RL
Sbjct: 122 IGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLAH 181
Query: 362 QLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMR 421
+ D E+L ++YE L A AE +A RIL GLGF P MQ + + FSGGWRMR
Sbjct: 182 E-----DAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMR 236
Query: 422 VSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDII 481
V+LARALF+ P +L+LDEPTNHLDL+A +WL L+ +++ L++VSH Q FL+ VCT+II
Sbjct: 237 VALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNII 296
Query: 482 HLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELK------AGGKSTKQAEK 535
H+ ++L YY GNY + K + ++ +K++ ++ ++ +K G + +
Sbjct: 297 HMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQA 356
Query: 536 QTKEALTRKQQKCRRKNQDEESQEAPELLKR-PKEYTVRFTFPDPPPLSPPVLGLHGVTF 594
Q+KE +K A L +R + T+ F FP + PPV+ + V+F
Sbjct: 357 QSKEKTLQKMM-------------ASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSF 403
Query: 595 GYQGQKP-LFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIG 653
Y P ++ NL+FGID+D+R+ +VGPNG GKSTLL LLTG+L PT G +RK+ +KIG
Sbjct: 404 KYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIG 463
Query: 654 FFNQQYAEQLRMEETPTEYLQRGFN--LPYQDARKCLGRFGLESHAHTIQICKLSGGQKA 711
++Q EQL ++ +P EY+ + + ++ RK +GR+GL I LS GQK
Sbjct: 464 RYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKC 523
Query: 712 RVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQL 771
RV A LA + P +L LDEPTN+LDIE+IDAL +AINE++G +++VSHD RLI + ++
Sbjct: 524 RVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEI 583
Query: 772 WVVEEQSVSQIDGDFEDYKREVLEAL 797
WV E+Q++++ GD YK + L
Sbjct: 584 WVCEKQTITKWPGDILAYKEHLKSKL 609
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 75.5 bits (184), Expect = 2e-13
Identities = 64/272 (23%), Positives = 122/272 (44%), Gaps = 31/272 (11%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKD--------KKIKKTFFEELAVEDKQAGE 54
K+P+ + P E E+ SP+DK +K K +K K E+ +K+ +
Sbjct: 762 KSPEAKTPAKE-----EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPK 816
Query: 55 EEKV---LKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDE 111
+E+V +KE+E+ Q+ + ++ KK + K ++ + K+ K+ P +E
Sbjct: 817 KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE 876
Query: 112 EDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHP-PKPAKPEKNRINKAVSEEQQ 170
+ E KP+ K ++ + EE E+++K P P+ P K + + +++
Sbjct: 877 KKEPAVEKPKESK-----------VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEK 925
Query: 171 PALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYE 230
+ K+ + K+K +KP K A +++ KEE K K+P ++ K +AK E +
Sbjct: 926 TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE---KAKKPEEKPKTEAKAKEDDKTL 982
Query: 231 RQVASLKAANAAENDFSVSQAEMSSRQAMLEN 262
+ S A AE S Q + + E+
Sbjct: 983 SKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
Score = 58.9 bits (141), Expect = 2e-08
Identities = 58/225 (25%), Positives = 99/225 (44%), Gaps = 15/225 (6%)
Query: 26 KVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE---KEQQQQQQQQQQKKKRDTRKG 82
KVV+K +K+ I + EE V ++ EEEK KE KE++ ++++ + + +T+
Sbjct: 445 KVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP 504
Query: 83 RRKKDVDDDGEEKE-LMERLKKLSVPTSDEEDEVPAP-KPRGGKKTKGGNVFAALIQDQS 140
++ + E K + E K + S E++E +P + + +K K A ++
Sbjct: 505 PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
Query: 141 EEEEEEEKHPPKPAKPEKNRINKAVSEEQQPA-------LKGKKGKEEKSKGKAKPQNKF 193
+ E+EE P K + + A E + PA K +E KS +AK K
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 194 AALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKA 238
A E E K K P K+ + +KA+ E E + KA
Sbjct: 625 EAKSPAEVKSPE---KAKSPTKEEAKSPEKAKSPEKEEAKSPEKA 666
Score = 56.2 bits (134), Expect = 1e-07
Identities = 64/276 (23%), Positives = 111/276 (40%), Gaps = 24/276 (8%)
Query: 10 PEPEWIGDGESTSPSDKVVKKGKKDKKI-------KKTFFEELAVEDKQAGEEEKVLKEK 62
P P + +G PS K K ++KI K+T E E+ Q EE +EK
Sbjct: 417 PIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEK 476
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
E ++++ ++++ + + +G ++ EE E+ K V EE + PA
Sbjct: 477 EAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPV---KEEAKSPAEAKSP 533
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEK 182
K+ + +EE K PP+ PEK K+ +E + P EK
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEA-KSPAEVKSP---------EK 583
Query: 183 SKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAA 242
+K AK + K A E + + +E + P + K K E+ + +V S + A +
Sbjct: 584 AKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVK--EEAKSPAEVKSPEKAKSP 641
Query: 243 ENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGK 278
+ + S + S + E A + K + A K
Sbjct: 642 TKEEAKSPEKAKSPEK--EEAKSPEKAKSPVKAEAK 675
Score = 53.1 bits (126), Expect = 1e-06
Identities = 47/193 (24%), Positives = 86/193 (44%), Gaps = 10/193 (5%)
Query: 2 PKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE 61
P+ K + P + + +P + K KK++ KK + E K+ E+ KE
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP--KE 887
Query: 62 KEQQQQQQQQQQKKKRDT--RKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPK 119
+ + ++++ + KKK T ++ K +V +D + KE E KK +E PA K
Sbjct: 888 SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEK 947
Query: 120 PRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPK-----PAKPEKNRINKAVSEEQQPALK 174
+ K A ++ + E + K K P+KP+ + K+ S +Q+ +
Sbjct: 948 KEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKP 1007
Query: 175 GKKGKEEK-SKGK 186
+K E+K +KGK
Sbjct: 1008 PEKATEDKAAKGK 1020
Score = 51.2 bits (121), Expect = 4e-06
Identities = 68/299 (22%), Positives = 118/299 (39%), Gaps = 28/299 (9%)
Query: 3 KAPKQQPPEPEWIGDGESTSPS---DKVVKKGKKDKKIKKTFFEELAVEDK-------QA 52
KA + P + + E+ SP V ++ K +K K EE +K +A
Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA 744
Query: 53 GEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112
EK ++ + + + K + R D + + + E +K S +
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804
Query: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPA 172
++ AP+ KK + + ++++ + +E + K PPK A+ EK +EE++ +
Sbjct: 805 EDAKAPEKEIPKKEE----VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPK-TEEKKDS 859
Query: 173 LKGKKGKEEKSKGKA---------KP-QNKFAALDNEEEDKEEEIIKEKEPPK--QGKEK 220
K + K+E K K KP ++K A E EDK++ EKE P + KE
Sbjct: 860 KKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKED 919
Query: 221 AKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKE 279
AK E+ E ++ A +A + E A + EK A KE
Sbjct: 920 AKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPE-EKPKTEAKAKE 977
Score = 48.9 bits (115), Expect = 2e-05
Identities = 48/225 (21%), Positives = 94/225 (41%), Gaps = 5/225 (2%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDK-QAGEEEKVLKEKEQQQQQQQQQQKKKR 77
E T +++V ++ +K+ K ++ EE E++ + GEEE E+ +++ + +
Sbjct: 462 EETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVK 521
Query: 78 DTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ 137
+ K + + E K E + +E+ P+ + +K + +
Sbjct: 522 EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSP 581
Query: 138 DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEE-KSKGKAKPQNKFAAL 196
++++ +EE P AK + + E + PA KEE KS + K K +
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641
Query: 197 DNEEEDKEEEIIKEKEPPKQGKEKAK---KAEQMEYERQVASLKA 238
EE E+ ++ + EKAK KAE E+ + +KA
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKA 686
Score = 45.1 bits (105), Expect = 3e-04
Identities = 59/275 (21%), Positives = 104/275 (37%), Gaps = 9/275 (3%)
Query: 3 KAP-KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE 61
K+P K++ P + E K K + K + + E K E + +KE
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 62 KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPR 121
+ + + + +K K T++ K EKE + +K P E K
Sbjct: 625 EAKSPAEVKSPEKAKSPTKE-EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSP 683
Query: 122 GGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKG--K 179
+ K + ++++++ E+ K P K + V EE + K K +
Sbjct: 684 VKAEAKSPEKAKSPVKEEAKSPEKA-KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742
Query: 180 EEKSKGKAKPQNKFAALDNEEEDKEEEIIKE-KEPPKQGKEKAK---KAEQMEYERQVAS 235
E KS KAK K LD + + + +E + P + EKAK K E E+ +
Sbjct: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSP 802
Query: 236 LKAANAAENDFSVSQAEMSSRQAMLENASDIKLEK 270
LK A + E+ S E ++K+++
Sbjct: 803 LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837
Score = 40.4 bits (93), Expect = 0.007
Identities = 59/276 (21%), Positives = 101/276 (36%), Gaps = 27/276 (9%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQ 65
+++ E E GE + S + +K+ K EE + E++ K +
Sbjct: 485 EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544
Query: 66 QQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAP-KPRGGK 124
+ ++ + K + + K + EE + +K S ++E +P + + +
Sbjct: 545 KSPEKAKSPAKEEAKSPPEAKSPEK--EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE 602
Query: 125 KTKGGNVFAALIQDQSEEEEEEEKHPP----------KPAKPEKNRINKAVSEEQQPALK 174
K K A +++ +EE P P K E KA S E++ A
Sbjct: 603 KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS 662
Query: 175 GKKGK-----EEKSKGKAKPQNKFAALDNE-------EEDKEEEIIKEKEPPKQGKEKAK 222
+K K E KS KAK K A E EE K E K K P K+ + +
Sbjct: 663 PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPE--KAKSPVKEEAKSPE 720
Query: 223 KAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQA 258
KA+ E KA + + + + S +A
Sbjct: 721 KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKA 756
Score = 30.8 bits (68), Expect = 5.2
Identities = 21/76 (27%), Positives = 41/76 (53%), Gaps = 10/76 (13%)
Query: 506 QKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE--- 562
+KE +K K+E+K +E+K + K+AE++ A + ++K K ++ +EAP+
Sbjct: 816 KKEEVKSPVKEEEKPQEVKV-KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKV 874
Query: 563 ------LLKRPKEYTV 572
+++PKE V
Sbjct: 875 EEKKEPAVEKPKESKV 890
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 71.2 bits (173), Expect = 4e-12
Identities = 56/223 (25%), Positives = 109/223 (48%), Gaps = 27/223 (12%)
Query: 11 EPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQ 70
+P W + + K+GKK+++ ++ +E +K+ E EK K + +++++
Sbjct: 31 QPGWQSEIREREREIETRKEGKKERESERK--KERREREKRKREREKERKRERGKKEKKG 88
Query: 71 QQQKKKRDTRKGRRKKDVDDDGEEKELMERL-KKLSVPTSDEEDEVPAPKPRGGKKTKGG 129
+++K++R+ +K RR+K+ + +GEEKE ++ KK TS E E + R ++ K
Sbjct: 89 ERKKEERERKKRRREKE-NKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK-- 145
Query: 130 NVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKP 189
E ++EE+ + K K R K V E KEE+ K K +
Sbjct: 146 ----------ERERKKEEREKERERKERKKRERKQVGE-----------KEEERKEKERK 184
Query: 190 QNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
+ K + +E KE E + +E K+ K+K ++ ++ + +RQ
Sbjct: 185 ERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQ 227
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/199 (23%), Positives = 96/199 (48%), Gaps = 20/199 (10%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
+K ++ +K++K ++ E+ K+ E +K +EKE ++ ++++++KKK +GR
Sbjct: 67 EKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRT 126
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEE 144
K+ + ++E +K +E ++ K R ++ K Q +EEE
Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREKERERKERKKRERK---------QVGEKEEE 177
Query: 145 EEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKE 204
+EK + K E+NR +E++ + K+ +E K + K K + K E +
Sbjct: 178 RKEKERKERKKRERNR------KERKKERERKERRERKKERKKKEERK-----KERQKDR 226
Query: 205 EEIIKEKEPPKQGKEKAKK 223
+ +EKE K+ +++ KK
Sbjct: 227 QTNWREKERGKRERKERKK 245
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/191 (22%), Positives = 88/191 (46%), Gaps = 21/191 (10%)
Query: 67 QQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKT 126
Q + ++++++ +TRK +K+ + +E+ E+ K+ E E + RG K+
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKR--------EREKERKRERGKKEK 86
Query: 127 KGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGK 186
KG + + EE E +++ K K + + + E+++ K+GKE + K +
Sbjct: 87 KG--------ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEE 138
Query: 187 AKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDF 246
K + + E E K+EE KE+E ++ K + K+ + E ER+ K E +
Sbjct: 139 RKREER-----KERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNR 193
Query: 247 SVSQAEMSSRQ 257
+ E ++
Sbjct: 194 KERKKERERKE 204
Score = 42.7 bits (99), Expect = 0.001
Identities = 39/166 (23%), Positives = 69/166 (41%), Gaps = 10/166 (6%)
Query: 110 DEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQ 169
+ E E+ K GKK + + + + E E++ + K EK K E+
Sbjct: 40 EREREIETRKE--GKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERER 97
Query: 170 QPALKGKKGKE--EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQM 227
+ + K+ KE EK K K K + + E +++E KE+ ++ KE+ +K E+
Sbjct: 98 KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERER---KEERKREERKERERKKEER 154
Query: 228 EYERQVASLK---AANAAENDFSVSQAEMSSRQAMLENASDIKLEK 270
E ER+ K E + + E R+ N + K E+
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER 200
Score = 38.9 bits (89), Expect = 0.019
Identities = 19/68 (27%), Positives = 43/68 (63%), Gaps = 1/68 (1%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQA-EKQTKEALTRKQQKCRRKNQDEESQEAP 561
++++KE + EK+++K KE K G+++K+ E++ KE R+++K R + ++E +E
Sbjct: 100 RRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERE 159
Query: 562 ELLKRPKE 569
++ +E
Sbjct: 160 RKERKKRE 167
Score = 34.3 bits (77), Expect = 0.47
Identities = 21/82 (25%), Positives = 42/82 (51%), Gaps = 11/82 (13%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGG-----------KSTKQAEKQTKEALTRKQQK 547
+K ++K++E K+ E++E+K +E K G K K+ E+ KE +++K
Sbjct: 144 RKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERK 203
Query: 548 CRRKNQDEESQEAPELLKRPKE 569
RR+ + E ++ +R K+
Sbjct: 204 ERRERKKERKKKEERKKERQKD 225
Score = 33.9 bits (76), Expect = 0.62
Identities = 16/67 (23%), Positives = 42/67 (62%), Gaps = 3/67 (4%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 562
++K++ ++ K+E++ + + GK K+ E++ +E R+++K RR+ +++E +E +
Sbjct: 58 ERKKERREREKRKREREKERKRERGKKEKKGERKKEE---RERKKRRREKENKEGEEKEK 114
Query: 563 LLKRPKE 569
K+ K+
Sbjct: 115 RKKKEKK 121
Score = 32.3 bits (72), Expect = 1.8
Identities = 18/61 (29%), Positives = 37/61 (60%), Gaps = 2/61 (3%)
Query: 511 KQYEKQEKKLKELKAGGKSTKQA--EKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPK 568
K+ E++EK+ KE K ++ K+ E++ KE RK+++ +++ + +E Q+ + R K
Sbjct: 174 KEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREK 233
Query: 569 E 569
E
Sbjct: 234 E 234
Score = 31.2 bits (69), Expect = 4.0
Identities = 21/76 (27%), Positives = 43/76 (56%), Gaps = 5/76 (6%)
Query: 499 KKMYQQKQKELLKQYEKQEKKL----KELKAGGKSTKQAEKQTKE-ALTRKQQKCRRKNQ 553
K+ +K+K+ ++ E++E+K KE K G + K+ +K+ KE T K+ K R + +
Sbjct: 78 KRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKE 137
Query: 554 DEESQEAPELLKRPKE 569
+ + +E E ++ +E
Sbjct: 138 ERKREERKERERKKEE 153
Score = 31.2 bits (69), Expect = 4.0
Identities = 19/72 (26%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELK--AGGKSTKQAEKQTKEALTRKQQKCRRKNQDEE 556
KK + KE ++ K+E+K +E K K ++ E++ KE R++++ K ++ +
Sbjct: 120 KKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERK 179
Query: 557 SQEAPELLKRPK 568
+E E KR +
Sbjct: 180 EKERKERKKRER 191
Score = 31.2 bits (69), Expect = 4.0
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 5/70 (7%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
K+ ++K++E ++ K+E++ KE + K K+ E++ KE +QK R+ N E+ +
Sbjct: 181 KERKERKKRERNRKERKKERERKERRERKKERKKKEERKKE-----RQKDRQTNWREKER 235
Query: 559 EAPELLKRPK 568
E +R K
Sbjct: 236 GKRERKERKK 245
Score = 30.0 bits (66), Expect = 8.9
Identities = 23/74 (31%), Positives = 43/74 (58%), Gaps = 10/74 (13%)
Query: 503 QQKQKELLKQYEKQEK-------KLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDE 555
++++KE ++ E++EK K +E K G+ K+ E++ KE RK+++ RK + +
Sbjct: 141 REERKERERKKEEREKERERKERKKRERKQVGE--KEEERKEKERKERKKRERNRKERKK 198
Query: 556 ESQEAPELLKRPKE 569
E +E E +R KE
Sbjct: 199 E-RERKERRERKKE 211
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 70.5 bits (171), Expect = 6e-12
Identities = 94/397 (23%), Positives = 169/397 (42%), Gaps = 51/397 (12%)
Query: 30 KGKKDKKIKKTFF---------EELAVEDK--QAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
KGKK K+ KK F EEL++E + +A E +K E +++ + KKK+
Sbjct: 41 KGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKG 100
Query: 79 TRKGRRKKDVDDDGEEKELME-RLKKLSVP-------TSDEEDEVPAPKPRGGKKTKGGN 130
+KG+++ D+D EE E + + KK + P + D++D PK GK K
Sbjct: 101 -QKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNK 159
Query: 131 VFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKA--VSEEQQPALKGKKGKEEKSKGKAK 188
+ D SEE+E+ K E++RIN + +E L+ +KG+++ K K
Sbjct: 160 KW-----DGSEEDEDNSKKIK-----ERSRINSSGESGDESDEFLQSRKGQKKNQKNKPG 209
Query: 189 PQNKFAALDNEEEDKEEEI--IKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDF 246
P + NE++D +I + +K+ K+ +E+ K+ E+ R++ + + D
Sbjct: 210 PNIESG---NEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQ 266
Query: 247 S-VSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKT 305
S +++ + +++ + S E A+ G K K
Sbjct: 267 SKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAE-----DDNEGDKKKKDKKKK 321
Query: 306 TLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLL--------EEER 357
K + P+ + QE +A + R + +R+K L EEER
Sbjct: 322 KGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEER 381
Query: 358 RLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKAR 394
Q + E+ ER E++ +E + + EA+AR
Sbjct: 382 LEQEKRERKKQKEKERKERLKKEGKLLTKSQREARAR 418
Score = 61.2 bits (147), Expect = 4e-09
Identities = 74/297 (24%), Positives = 133/297 (44%), Gaps = 41/297 (13%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVV----KKGKKDKKIKKTFFEELAVEDKQAGEEEKV 58
K ++ P P E S K+ KK +K ++ +K EE A + ++ E+E++
Sbjct: 201 KKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKA-KLRKLKEKEEL 259
Query: 59 LKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAP 118
K+ Q +Q++ Q+K + +T K + D +E K PT+ E+D
Sbjct: 260 ETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEE------KAETPTAAEDDNEGDK 313
Query: 119 KPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKG 178
K + KK KG + EE+E+E+K P +KA + Q AL K
Sbjct: 314 KKKDKKKKKG----------EKEEKEKEKKKGP----------SKATVKAMQEALAKLKE 353
Query: 179 KEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQV---AS 235
+EE+ K + + + K + +EE + +EK K+ KEK +K E+++ E ++ +
Sbjct: 354 EEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERK-ERLKKEGKLLTKSQ 412
Query: 236 LKAANAAENDFSVSQA---EMSSRQAMLENA---SDIKLEKFSISAHGKELFVNADL 286
+A AE + QA E+ S+ ++ + D K +K KE+ + +L
Sbjct: 413 REARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMEL 469
Score = 58.9 bits (141), Expect = 2e-08
Identities = 69/317 (21%), Positives = 127/317 (40%), Gaps = 63/317 (19%)
Query: 10 PEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKV---------LK 60
P E + + + D K KKDKK KK EE E K+ + V LK
Sbjct: 293 PASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLK 352
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGE--------EKELMERLKK--------- 103
E+E++Q+++++++ K+ + + +RK++ + E EKE ERLKK
Sbjct: 353 EEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQ 412
Query: 104 ------------------LSVPTSD----------EEDEVPAPKPRGGKKTKGGNVFAAL 135
+ VP+ D ++ P+ K+ A
Sbjct: 413 REARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAA 472
Query: 136 IQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKG-------KAK 188
++ + E+E+ PP P +PE+ + + A+ + + EK +G K
Sbjct: 473 VEVMEQGVPEKEETPP-PVEPEEEEDTEDAGLDDWEAMASDE-ETEKVEGNKVHIEVKEN 530
Query: 189 PQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSV 248
P+ + + EEED+E E +E+E +G E ++ E++ E+ ++ S
Sbjct: 531 PEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSD 590
Query: 249 SQAEMSSRQAMLENASD 265
S+ + + E A D
Sbjct: 591 SEYDSDDDRTKEERAYD 607
Score = 51.6 bits (122), Expect = 3e-06
Identities = 55/214 (25%), Positives = 95/214 (44%), Gaps = 29/214 (13%)
Query: 31 GKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDD 90
GKK K + ++ D A E E KEQ+ Q+ + ++KK++ +K+D D+
Sbjct: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEK------KKQDFDE 55
Query: 91 DGEEKELME-----------RLKKLSVPTSDEEDEVPA-PKPRGGKKTKGGNVFAALIQD 138
D KEL E R PT + E+E + K + G+K K + +
Sbjct: 56 DDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKK----QSFDDN 111
Query: 139 QSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDN 198
SEE E+++ K AKP+ + + ++ L +K+KGKA+ NK
Sbjct: 112 DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKL------PKKAKGKAQKSNKKWDGSE 165
Query: 199 EEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
E+ED ++ IKE+ E ++++ R+
Sbjct: 166 EDEDNSKK-IKERSRINSSGESGDESDEFLQSRK 198
Score = 49.7 bits (117), Expect = 1e-05
Identities = 67/315 (21%), Positives = 126/315 (40%), Gaps = 105/315 (33%)
Query: 25 DKVVKKGKKDKKIK-----------KTFFEELAV----EDKQAGEEEKVLK--------- 60
DK KKG+K++K K K E LA E++Q EEE+ +K
Sbjct: 317 DKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKR 376
Query: 61 -EKEQQQQQQQQQQKKKRDTRKGRRKKD-------------------------------- 87
E+E+ +Q++++++K+K RK R KK+
Sbjct: 377 KEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSK 436
Query: 88 --------VDDDGEEKELMERLKKLSVPTS--------------DEEDEVPAP-KPRGGK 124
+ +D + K++ ++L+ V S E++E P P +P +
Sbjct: 437 DSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEE 496
Query: 125 KTKG-------------------GNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAV 165
T+ GN +++ EEEEEEE+ + + E+ +
Sbjct: 497 DTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGE 556
Query: 166 SEEQQPALKGKKGKEEKSKGKA---KPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK 222
SE + + +K +EK GK KP + ++ + E D +++ KE+ + K + +
Sbjct: 557 SEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSS--DSEYDSDDDRTKEERAYDKAKRRIE 614
Query: 223 KAEQMEYERQVASLK 237
K ++E+ + V + K
Sbjct: 615 K-RRLEHSKNVNTEK 628
Score = 30.8 bits (68), Expect = 5.2
Identities = 21/67 (31%), Positives = 41/67 (61%), Gaps = 3/67 (4%)
Query: 504 QKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTR-KQQKCRRKNQDEESQEAPE 562
+K+K+ K+ ++E+K KE K G +K K +EAL + K+++ R+K ++EE + E
Sbjct: 313 KKKKDKKKKKGEKEEKEKEKKKG--PSKATVKAMQEALAKLKEEEERQKREEEERIKRLE 370
Query: 563 LLKRPKE 569
L+ ++
Sbjct: 371 ELEAKRK 377
Score = 30.0 bits (66), Expect = 8.9
Identities = 38/197 (19%), Positives = 83/197 (42%), Gaps = 19/197 (9%)
Query: 23 PSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKG 82
P + + + KK KKI + +E K+ E ++ E +Q ++++
Sbjct: 440 PKKRPIYEDKKRKKIPQQ------LESKEVSESMELCAAVEVMEQGVPEKEETPPPVEP- 492
Query: 83 RRKKDVDDDG----------EEKELMERLK-KLSVPTSDEEDEVPAPKPRGGKKTKGGNV 131
++D +D G EE E +E K + V + EE+E + ++++
Sbjct: 493 EEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEE 552
Query: 132 FAALIQDQSEEEEEEEKHPPKPA-KPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQ 190
+ +EE+E+ K + K + +K +S + + + KEE++ KAK +
Sbjct: 553 EEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRR 612
Query: 191 NKFAALDNEEEDKEEEI 207
+ L++ + E++
Sbjct: 613 IEKRRLEHSKNVNTEKL 629
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 62.4 bits (150), Expect = 2e-09
Identities = 58/185 (31%), Positives = 90/185 (48%), Gaps = 20/185 (10%)
Query: 291 GRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRL 350
G LVGPNG GK+T+ + N L P +LL D P Q R +++
Sbjct: 591 GEVTALVGPNGSGKSTVAALLQN--LYQPTGGQLLL-------DGKPLPQYEHRYLHRQV 641
Query: 351 KLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGL--GFDPEMQN 408
+ +E ++ G+ Q + + EE+ A AA ++ A ++GL G+D E+
Sbjct: 642 AAVGQEPQVFGRSLQENIAYGLTQKPTMEEITA---AAVKSGAHSFISGLPQGYDTEVDE 698
Query: 409 RPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYL-----QGWRKTL 463
+Q SGG R V+LARAL +P +L+LD+ T+ LD N+ + + L + R L
Sbjct: 699 AGSQ-LSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVL 757
Query: 464 LIVSH 468
LI H
Sbjct: 758 LITQH 762
Score = 52.4 bits (124), Expect = 2e-06
Identities = 60/236 (25%), Positives = 97/236 (41%), Gaps = 45/236 (19%)
Query: 574 FTFPDPPPLSPPV-----LGLHG------VTFGYQGQKPLF--KNLDFGIDMDSRICIVG 620
F + D P PP L L G V+F Y + + + L F + +VG
Sbjct: 539 FEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVG 598
Query: 621 PNGVGKSTLLLLLTGKLTPTHGEM--------RKNHRLKIGFFNQQYAEQLRMEETPTEY 672
PNG GKST+ LL PT G++ + HR + ++Q A + +
Sbjct: 599 PNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHR----YLHRQVAAVGQEPQVFGRS 654
Query: 673 LQRG--FNLPYQDARKCLGRFGLESHAHTIQI--------------CKLSGGQKARVVFA 716
LQ + L + + + ++S AH+ +LSGGQ+ V A
Sbjct: 655 LQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALA 714
Query: 717 ELACREPDVLILDEPTNNLDIES----IDALGEAINEYKGAVIVVSHDARLITETN 768
R+P VLILD+ T+ LD S L E+ Y +V++++ L+ + +
Sbjct: 715 RALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQAD 770
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/262 (22%), Positives = 120/262 (45%), Gaps = 20/262 (7%)
Query: 22 SPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRK 81
S ++K V ++ +K E+ A + K +EK +K++ + + + ++++K+K
Sbjct: 601 SVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEV 660
Query: 82 GRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSE 141
+++ EEK E +KK V +++E PK K+T V + +++ +
Sbjct: 661 AKKEDKTPIKKEEKPKKEEVKK-EVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKK 719
Query: 142 EEEEEEKHPPKPAK---PEKNRINKAVSEEQQP-ALKGKKGKEEKSKGKAKPQNKFAALD 197
E ++EEK P K K + + + +SE ++P ALK K K+E+S K D
Sbjct: 720 EVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKK----------D 769
Query: 198 NEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAAN-----AAENDFSVSQAE 252
+ K +E K K K+GK A + A++ AA + ++
Sbjct: 770 SVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSL 829
Query: 253 MSSRQAMLENASDIKLEKFSIS 274
MSS + + ++ ++K E+ ++
Sbjct: 830 MSSPEDLTKDFEELKAEEVDVT 851
Score = 61.6 bits (148), Expect = 3e-09
Identities = 84/346 (24%), Positives = 153/346 (44%), Gaps = 48/346 (13%)
Query: 50 KQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDD----DGEEKELMERLKKLS 105
KQ + + LK + + +++ K +T + + V+ + +EK ++++ K +
Sbjct: 536 KQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIK 595
Query: 106 VPT--SDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEE---EEEKHPPKPAKPEKNR 160
T S E EVP+ + K + A ++ ++ +E+ +E K P+ K EK +
Sbjct: 596 TETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEK 655
Query: 161 INKAVS--EEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGK 218
K V+ E++ P K +K K+E+ K + K + K EE+ + ++ +K++ PPK+ K
Sbjct: 656 PKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIK-----KEEKKEPKKEVKKETPPKEVK 710
Query: 219 EKAKKAEQMEYERQVAS-LKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHG 277
++ KK E+ E +++ K D S +S +A A K+ K
Sbjct: 711 KEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLS--EAKKPAALKPKVPK------- 761
Query: 278 KELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETP 337
KE V D + AG+ P KGK ++K A ++ + V+A
Sbjct: 762 KEESVKKD-SVAAGK------PKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMA--AA 812
Query: 338 AVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRA 383
+ A+ A K LE ER L ++ E L K +EEL+A
Sbjct: 813 GIAAIGPA-----KELEAERSLM--------SSPEDLTKDFEELKA 845
Score = 32.7 bits (73), Expect = 1.4
Identities = 40/206 (19%), Positives = 88/206 (42%), Gaps = 27/206 (13%)
Query: 42 FEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQ-------KKKRDTRKGRRKKD------V 88
FEEL E+ ++ K E + +++ ++ + +K+R+ KG +
Sbjct: 840 FEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTT 899
Query: 89 DDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEK 148
+ +GE ++ E L+ + D+ ++ + ++ G+ ++++E EE EE
Sbjct: 900 EGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDY-----EEKAETEEAEE- 953
Query: 149 HPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEII 208
P + + + + S+ + E + + K ++ + D EED +E I
Sbjct: 954 ----PEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIE 1009
Query: 209 K----EKEPPKQGKEKAKKAEQMEYE 230
K + E ++KA+ A + EYE
Sbjct: 1010 KGEAEQSEEEADEEDKAEDAREEEYE 1035
Score = 31.2 bits (69), Expect = 4.0
Identities = 22/88 (25%), Positives = 44/88 (50%), Gaps = 2/88 (2%)
Query: 500 KMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQ--AEKQTKEALTRKQQKCRRKNQDEES 557
K ++ +KE +K+ K+E K +E K K K+ K+ K+ + ++++K +K + E
Sbjct: 670 KKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPK 729
Query: 558 QEAPELLKRPKEYTVRFTFPDPPPLSPP 585
+E +L K K+ + + P P
Sbjct: 730 KEIKKLPKDAKKSSTPLSEAKKPAALKP 757
Score = 31.2 bits (69), Expect = 4.0
Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 10/73 (13%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQ--DEE 556
K ++ +KE+ K+ +K+EKK + K+ +K+T +K+ K K + EE
Sbjct: 674 KPKKEEVKKEVKKEIKKEEKK--------EPKKEVKKETPPKEVKKEVKKEEKKEVKKEE 725
Query: 557 SQEAPELLKRPKE 569
+ E+ K PK+
Sbjct: 726 KEPKKEIKKLPKD 738
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 61.2 bits (147), Expect = 4e-09
Identities = 48/186 (25%), Positives = 94/186 (50%), Gaps = 25/186 (13%)
Query: 50 KQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTS 109
++ EEE+ L+ K++Q+++ +Q+ K K R+K+ E+K+L+E+ + T
Sbjct: 832 RKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLREKE-----EQKKLLEQRAQYVEKTK 886
Query: 110 D-----EEDEVPAPKPR---GGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRI 161
+ E E K R GG+++K G F + D ++++ P +K R
Sbjct: 887 NILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDD--------LPISKKKKRR 938
Query: 162 NKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKA 221
+ SE++ +G G+ +K K + P+ + + D+E E+ + K++ PPK K+KA
Sbjct: 939 KGSGSEQEGEDEEG--GERKKKKRRRHPKGEEGSDDDETENGPKP--KKRRPPKAEKKKA 994
Query: 222 KKAEQM 227
K E++
Sbjct: 995 PKPERL 1000
Score = 44.7 bits (104), Expect = 4e-04
Identities = 43/237 (18%), Positives = 102/237 (43%), Gaps = 16/237 (6%)
Query: 16 GDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKE-------QQQQQ 68
G+ E+T + G++ KK + F+E +D ++ + K+K+ +Q+ +
Sbjct: 893 GETEATKEKKRGGGGGRRSKKGGE--FDEFVNDDTD--DDLPISKKKKRRKGSGSEQEGE 948
Query: 69 QQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKG 128
++ ++K+ R+ K + D +E E + KK P ++++ APKP +
Sbjct: 949 DEEGGERKKKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAEKKK---APKPERLPPSMK 1005
Query: 129 GNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAK 188
G + + I S++ +E+K +N + + S+E + K + + + + K
Sbjct: 1006 GKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSNSDSDEDEQRKKCASSESDSDENQNK 1065
Query: 189 PQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAEND 245
++ + + ++ +P + K + +EQ + E + + +END
Sbjct: 1066 SGSEAGSPRRPRRQRSDQDSDSDQPSR--KRRPSGSEQSDNESVQSGRSHSGVSEND 1120
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 61.2 bits (147), Expect = 4e-09
Identities = 59/265 (22%), Positives = 122/265 (46%), Gaps = 16/265 (6%)
Query: 17 DGESTSPSDKVVKKGKKDKK--IKKTFFEELA--VEDKQAGEEEKVLKEKEQ-QQQQQQQ 71
+GE KV + KK +K IKK +E A VE K+ G+ + + + Q +
Sbjct: 313 EGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAK 372
Query: 72 QQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNV 131
+ +KK D++K ++ +V+ +K+ + + +E VP+ K K +
Sbjct: 373 KDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEE 432
Query: 132 FAALIQDQS---EEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAK 188
A+ ++ ++EE+ K + + EK+ ++ ++++P +KGK+ K S + +
Sbjct: 433 IGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEP-IKGKEEKVPASLKEKE 491
Query: 189 PQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSV 248
P+ K +E+ K + +K K P QGK++ K Q++ E + A + + D
Sbjct: 492 PETK----KDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVK 547
Query: 249 SQAEMS---SRQAMLENASDIKLEK 270
+ +S + +L+ + +EK
Sbjct: 548 PEKTVSHGKPEEKVLKQVKAVTIEK 572
Score = 56.6 bits (135), Expect = 9e-08
Identities = 65/273 (23%), Positives = 120/273 (43%), Gaps = 25/273 (9%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGK-----KDKKIKKTFFEELAVEDKQAGEEEK 57
K KQ+ PE + T + K +KGK K+K KK +E +E K+ E +
Sbjct: 147 KTEKQEKPERKI-----QTKVTHKEKEKGKEKVREKEKPEKKATHKE-KIEKKEKPETKT 200
Query: 58 VLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA 117
+ KE+++ + ++ ++K K++ + G+++K + KE+ K S P E+ E A
Sbjct: 201 LAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQ---KTPSKPKEKEDKEKAA 257
Query: 118 PKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKK 177
K + I + + + P P E+ S PAL+ K+
Sbjct: 258 VSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPAS----PALEEKE 313
Query: 178 GKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLK 237
G+++K++ K + K E+ED +++ KE + KE K +E + ++A
Sbjct: 314 GEKKKAEKKVTSETK----KKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIA--- 366
Query: 238 AANAAENDFSVSQAEMSSRQAMLENASDIKLEK 270
A AA+ D ++ + + A +E K EK
Sbjct: 367 AQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEK 399
Score = 44.7 bits (104), Expect = 4e-04
Identities = 35/142 (24%), Positives = 73/142 (51%), Gaps = 15/142 (10%)
Query: 132 FAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQN 191
F +L+ D E+EE+ + +K I+ +P L+ K+ ++K++ + KP+
Sbjct: 106 FFSLLSDIISSEDEEDDDGDEDT--DKGEID-------EPPLRKKEIHKDKTEKQEKPER 156
Query: 192 KFAA-LDNEEEDKEEEIIKEKEPPKQ---GKEKAKKAEQMEYERQVASLKAANAAENDFS 247
K + ++E++K +E ++EKE P++ KEK +K E+ E + K A AE
Sbjct: 157 KIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEE 216
Query: 248 VSQAEM--SSRQAMLENASDIK 267
++ E+ ++ + + A+ +K
Sbjct: 217 KTKKEVKGGKQEKVKQTAAKVK 238
Score = 30.4 bits (67), Expect = 6.8
Identities = 20/80 (25%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
Query: 497 TFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKE-------ALTRKQQKCR 549
T K+ ++K+K K K++KK K + + TK+ K K+ A ++ QK
Sbjct: 185 THKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTP 244
Query: 550 RKNQDEESQEAPELLKRPKE 569
K +++E +E + K ++
Sbjct: 245 SKPKEKEDKEKAAVSKHEQK 264
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 60.8 bits (146), Expect = 5e-09
Identities = 59/242 (24%), Positives = 110/242 (45%), Gaps = 17/242 (7%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
KA + E E + E ++ +G K + ++ E+ +K+ GE+E+ E
Sbjct: 514 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 573
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
E + ++ + +++KK + + + + K K VP S E++ +P P+
Sbjct: 574 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 633
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNR--INKAVSEEQ------QPALK 174
+ KG + +S EE+ + PK EK + ++K+ EE+ + ++
Sbjct: 634 PVEEKGKSPV-----PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVE 688
Query: 175 GKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVA 234
K K E KG+ K + + + +E KEE++ K++E PK EK KKAE E VA
Sbjct: 689 EAKSKAEVGKGEQKEEEE---KEVKEAPKEEKVEKKEEKPKDVPEK-KKAESPVKEEAVA 744
Query: 235 SL 236
+
Sbjct: 745 EV 746
Score = 49.7 bits (117), Expect = 1e-05
Identities = 56/222 (25%), Positives = 95/222 (42%), Gaps = 23/222 (10%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
K+P + P E G+S P V +KGK + K+ EE E+ K K
Sbjct: 627 KSPVPKSPVEE---KGKSPVPKSPVEEKGKSP--VPKSPVEEKGKSPVSKSPVEE--KAK 679
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
+ ++ K K + KG +K++ EEKE+ E K+ V +E+ + K +
Sbjct: 680 SPVPKSPVEEAKSKAEVGKGEQKEE-----EEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 734
Query: 123 GKKTKGGNVFAALIQDQSEEE--EEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
K V + +S + E+E K KP + EK E+++ +G +E
Sbjct: 735 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK--------EKEKAGGEGGSEEE 786
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK 222
KG + + A++ E E KE E+ +E + G+E+ K
Sbjct: 787 GSDKGAKGSRKEDIAVNGEVEGKE-EVEQETKEKGSGREEEK 827
Score = 47.8 bits (112), Expect = 4e-05
Identities = 49/233 (21%), Positives = 98/233 (42%), Gaps = 30/233 (12%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGE----EE 56
+PK+P ++ +G GE +K VK+ K++K++K + V +K+ E EE
Sbjct: 682 VPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 741
Query: 57 KVL--------------KEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
V KE +++ + QQ+++K++ +G +++ D G + E +
Sbjct: 742 AVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA 801
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
EE E + G++ + G V L ++E++ +K EK +
Sbjct: 802 VNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDK------SEEKVVVT 855
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPK 215
K V + +G + +K K ++ EE EE+++ K+ K
Sbjct: 856 KTVEKIT------SEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 902
Score = 47.4 bits (111), Expect = 5e-05
Identities = 45/193 (23%), Positives = 91/193 (47%), Gaps = 28/193 (14%)
Query: 36 KIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEK 95
K++ F EE+ +E+ + E+EK E+ ++ K + ++ +K+ + + EE+
Sbjct: 447 KVQHKFVEEI-IEETKV-EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEE 504
Query: 96 ELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAK 155
E ++ S + P K G+K +++ +EEEEEE K +
Sbjct: 505 E-------VAAKKSPVKATAPEVKEEEGEKE----------EEEGQEEEEEEDEGAKSDQ 547
Query: 156 PEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEE--EDKEEEIIKEKEP 213
E+ K S E++ +G++E+ + +A+ + + A E+ E+K EE+ ++E
Sbjct: 548 AEEGGSEKEGSSEKE------EGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 601
Query: 214 PKQGK-EKAKKAE 225
K EK +KA+
Sbjct: 602 VADAKVEKPEKAK 614
Score = 47.0 bits (110), Expect = 7e-05
Identities = 53/248 (21%), Positives = 110/248 (44%), Gaps = 27/248 (10%)
Query: 17 DGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKK 76
+GE+ + ++ + K++KK+++ ++ A +EE V K ++ ++ + K
Sbjct: 568 EGETEAEAEGEEAEAKEEKKVEEK-------SEEVATKEELVADAKVEKPEKAKSPVPKS 620
Query: 77 RDTRKGRR---KKDVDDDGEE---KELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGN 130
KG+ K V++ G+ K +E K VP S E++ +P + + K +
Sbjct: 621 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS 680
Query: 131 -VFAALIQD--------QSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEE 181
V + +++ + E++EEEEK + K EK + ++ K + +E
Sbjct: 681 PVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKE 740
Query: 182 KSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANA 241
++ + K + E+E KE E +P +Q KEK K + E + + A +
Sbjct: 741 EAVAEVVTITKSVKVHLEKETKE-----EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGS 795
Query: 242 AENDFSVS 249
+ D +V+
Sbjct: 796 RKEDIAVN 803
Score = 46.6 bits (109), Expect = 9e-05
Identities = 53/231 (22%), Positives = 103/231 (44%), Gaps = 18/231 (7%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQ-QKKKR 77
E + S K KK ++K ++ EE V K++ + + KE++ ++++++ Q+++
Sbjct: 478 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 537
Query: 78 DTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG------GKKTKGGNV 131
+ +G + ++ G EKE ++ + E E + +K++
Sbjct: 538 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVAT 597
Query: 132 FAALIQDQSEEEEEEEKHP-PKPAKPEKNR--INKAVSEE--QQPALKG---KKGKEEKS 183
L+ D E+ E+ K P PK EK + + K+ EE + P K +KGK
Sbjct: 598 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 657
Query: 184 KGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK--KAEQMEYERQ 232
K + + K + E+K + + K P ++ K KA+ K EQ E E +
Sbjct: 658 KSPVEEKGKSPVSKSPVEEKAKSPV-PKSPVEEAKSKAEVGKGEQKEEEEK 707
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/227 (22%), Positives = 95/227 (41%), Gaps = 21/227 (9%)
Query: 1 MPKAP---KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVE-----DKQA 52
+PK+P K + P P+ + + SP K + K + K+ EE + +Q
Sbjct: 643 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 702
Query: 53 GEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112
EEEK +KE ++++ +++++K K K + + V ++ E++ K + V E
Sbjct: 703 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEA-VAEVVTITKSVKVHLEKET 761
Query: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAV--SEEQQ 170
E P + +K K G + EEE K ++ E +N V EE +
Sbjct: 762 KEEGKPLQQEKEKEKAGG--------EGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE 813
Query: 171 PALKGKKGKEEKSKGKAKPQNKFAALDNEE--EDKEEEIIKEKEPPK 215
K K E+ KG + D ++ + EE+++ K K
Sbjct: 814 QETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEK 860
Score = 45.8 bits (107), Expect = 2e-04
Identities = 46/238 (19%), Positives = 91/238 (38%), Gaps = 1/238 (0%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
EELAV K+ +E KE+E + ++++ KK K+ + + EE+E E +
Sbjct: 478 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 537
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
+ ++ E + G + + G + ++E EE E K K + +
Sbjct: 538 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVAT 597
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK 222
K K +K K K + + K + E+K + + + ++GK
Sbjct: 598 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 657
Query: 223 KAEQMEYERQ-VASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKE 279
K+ E + V+ A++ S E + +A + + E+ + KE
Sbjct: 658 KSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKE 715
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/172 (24%), Positives = 81/172 (47%), Gaps = 12/172 (6%)
Query: 104 LSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINK 163
+++ + ++ +V APK + K +I++ E+E+ E A E+ +
Sbjct: 430 ITISSKIQKPKVEAPKLKVQHK-----FVEEIIEETKVEDEKSEMEEALTAITEELAV-- 482
Query: 164 AVSEEQQPALKGK----KGKEEKSKGKAKPQNKFAALDNEEE-DKEEEIIKEKEPPKQGK 218
++ EE++ A + K + +EE+ K P A EEE +KEEE +E+E +
Sbjct: 483 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 542
Query: 219 EKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEK 270
K+ +AE+ E++ +S K E + ++AE +A E + K E+
Sbjct: 543 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 594
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 60.8 bits (146), Expect = 5e-09
Identities = 59/242 (24%), Positives = 110/242 (45%), Gaps = 17/242 (7%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
KA + E E + E ++ +G K + ++ E+ +K+ GE+E+ E
Sbjct: 138 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 197
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
E + ++ + +++KK + + + + K K VP S E++ +P P+
Sbjct: 198 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 257
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNR--INKAVSEEQ------QPALK 174
+ KG + +S EE+ + PK EK + ++K+ EE+ + ++
Sbjct: 258 PVEEKGKSPV-----PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVE 312
Query: 175 GKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVA 234
K K E KG+ K + + + +E KEE++ K++E PK EK KKAE E VA
Sbjct: 313 EAKSKAEVGKGEQKEEEE---KEVKEAPKEEKVEKKEEKPKDVPEK-KKAESPVKEEAVA 368
Query: 235 SL 236
+
Sbjct: 369 EV 370
Score = 49.7 bits (117), Expect = 1e-05
Identities = 56/222 (25%), Positives = 95/222 (42%), Gaps = 23/222 (10%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
K+P + P E G+S P V +KGK + K+ EE E+ K K
Sbjct: 251 KSPVPKSPVEE---KGKSPVPKSPVEEKGKSP--VPKSPVEEKGKSPVSKSPVEE--KAK 303
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
+ ++ K K + KG +K++ EEKE+ E K+ V +E+ + K +
Sbjct: 304 SPVPKSPVEEAKSKAEVGKGEQKEE-----EEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 358
Query: 123 GKKTKGGNVFAALIQDQSEEE--EEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
K V + +S + E+E K KP + EK E+++ +G +E
Sbjct: 359 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK--------EKEKAGGEGGSEEE 410
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK 222
KG + + A++ E E KE E+ +E + G+E+ K
Sbjct: 411 GSDKGAKGSRKEDIAVNGEVEGKE-EVEQETKEKGSGREEEK 451
Score = 47.8 bits (112), Expect = 4e-05
Identities = 49/233 (21%), Positives = 98/233 (42%), Gaps = 30/233 (12%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGE----EE 56
+PK+P ++ +G GE +K VK+ K++K++K + V +K+ E EE
Sbjct: 306 VPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 365
Query: 57 KVL--------------KEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
V KE +++ + QQ+++K++ +G +++ D G + E +
Sbjct: 366 AVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA 425
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
EE E + G++ + G V L ++E++ +K EK +
Sbjct: 426 VNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDK------SEEKVVVT 479
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPK 215
K V + +G + +K K ++ EE EE+++ K+ K
Sbjct: 480 KTVEKIT------SEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 526
Score = 47.4 bits (111), Expect = 5e-05
Identities = 45/193 (23%), Positives = 91/193 (47%), Gaps = 28/193 (14%)
Query: 36 KIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEK 95
K++ F EE+ +E+ + E+EK E+ ++ K + ++ +K+ + + EE+
Sbjct: 71 KVQHKFVEEI-IEETKV-EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEE 128
Query: 96 ELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAK 155
E ++ S + P K G+K +++ +EEEEEE K +
Sbjct: 129 E-------VAAKKSPVKATAPEVKEEEGEKE----------EEEGQEEEEEEDEGAKSDQ 171
Query: 156 PEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEE--EDKEEEIIKEKEP 213
E+ K S E++ +G++E+ + +A+ + + A E+ E+K EE+ ++E
Sbjct: 172 AEEGGSEKEGSSEKE------EGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 225
Query: 214 PKQGK-EKAKKAE 225
K EK +KA+
Sbjct: 226 VADAKVEKPEKAK 238
Score = 47.0 bits (110), Expect = 7e-05
Identities = 53/248 (21%), Positives = 110/248 (44%), Gaps = 27/248 (10%)
Query: 17 DGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKK 76
+GE+ + ++ + K++KK+++ ++ A +EE V K ++ ++ + K
Sbjct: 192 EGETEAEAEGEEAEAKEEKKVEEK-------SEEVATKEELVADAKVEKPEKAKSPVPKS 244
Query: 77 RDTRKGRR---KKDVDDDGEE---KELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGN 130
KG+ K V++ G+ K +E K VP S E++ +P + + K +
Sbjct: 245 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS 304
Query: 131 -VFAALIQD--------QSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEE 181
V + +++ + E++EEEEK + K EK + ++ K + +E
Sbjct: 305 PVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKE 364
Query: 182 KSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANA 241
++ + K + E+E KE E +P +Q KEK K + E + + A +
Sbjct: 365 EAVAEVVTITKSVKVHLEKETKE-----EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGS 419
Query: 242 AENDFSVS 249
+ D +V+
Sbjct: 420 RKEDIAVN 427
Score = 46.6 bits (109), Expect = 9e-05
Identities = 53/231 (22%), Positives = 103/231 (44%), Gaps = 18/231 (7%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQ-QKKKR 77
E + S K KK ++K ++ EE V K++ + + KE++ ++++++ Q+++
Sbjct: 102 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 161
Query: 78 DTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG------GKKTKGGNV 131
+ +G + ++ G EKE ++ + E E + +K++
Sbjct: 162 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVAT 221
Query: 132 FAALIQDQSEEEEEEEKHP-PKPAKPEKNR--INKAVSEE--QQPALKG---KKGKEEKS 183
L+ D E+ E+ K P PK EK + + K+ EE + P K +KGK
Sbjct: 222 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 281
Query: 184 KGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK--KAEQMEYERQ 232
K + + K + E+K + + K P ++ K KA+ K EQ E E +
Sbjct: 282 KSPVEEKGKSPVSKSPVEEKAKSPV-PKSPVEEAKSKAEVGKGEQKEEEEK 331
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/227 (22%), Positives = 95/227 (41%), Gaps = 21/227 (9%)
Query: 1 MPKAP---KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVE-----DKQA 52
+PK+P K + P P+ + + SP K + K + K+ EE + +Q
Sbjct: 267 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 326
Query: 53 GEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112
EEEK +KE ++++ +++++K K K + + V ++ E++ K + V E
Sbjct: 327 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEA-VAEVVTITKSVKVHLEKET 385
Query: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAV--SEEQQ 170
E P + +K K G + EEE K ++ E +N V EE +
Sbjct: 386 KEEGKPLQQEKEKEKAGG--------EGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE 437
Query: 171 PALKGKKGKEEKSKGKAKPQNKFAALDNEE--EDKEEEIIKEKEPPK 215
K K E+ KG + D ++ + EE+++ K K
Sbjct: 438 QETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEK 484
Score = 45.8 bits (107), Expect = 2e-04
Identities = 46/238 (19%), Positives = 91/238 (38%), Gaps = 1/238 (0%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
EELAV K+ +E KE+E + ++++ KK K+ + + EE+E E +
Sbjct: 102 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 161
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
+ ++ E + G + + G + ++E EE E K K + +
Sbjct: 162 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVAT 221
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK 222
K K +K K K + + K + E+K + + + ++GK
Sbjct: 222 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 281
Query: 223 KAEQMEYERQ-VASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKE 279
K+ E + V+ A++ S E + +A + + E+ + KE
Sbjct: 282 KSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKE 339
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/172 (24%), Positives = 81/172 (47%), Gaps = 12/172 (6%)
Query: 104 LSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINK 163
+++ + ++ +V APK + K +I++ E+E+ E A E+ +
Sbjct: 54 ITISSKIQKPKVEAPKLKVQHK-----FVEEIIEETKVEDEKSEMEEALTAITEELAV-- 106
Query: 164 AVSEEQQPALKGK----KGKEEKSKGKAKPQNKFAALDNEEE-DKEEEIIKEKEPPKQGK 218
++ EE++ A + K + +EE+ K P A EEE +KEEE +E+E +
Sbjct: 107 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 166
Query: 219 EKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEK 270
K+ +AE+ E++ +S K E + ++AE +A E + K E+
Sbjct: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 218
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 60.8 bits (146), Expect = 5e-09
Identities = 81/381 (21%), Positives = 151/381 (39%), Gaps = 55/381 (14%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
E++ EDK+ E E+ E E++++ + +Q KK D R R + + +E+E E
Sbjct: 255 EKMEEEDKERAEAERARLEAEERERIKAEQDKKIADER-ARIEAEEKAAAQERERRE--- 310
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
++E + + + R ++ + +EEEK + + K
Sbjct: 311 ------AEERERMREEEKRAA--------------EERQRIKEEEKRAAEERQRIKEEEK 350
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK 222
+A E Q+ + K+ EE+ + +A+ + K EE+ + +++ ++K ++ K K +
Sbjct: 351 RAAEERQRIKEEEKRAAEERQRARAEEEEKAKV---EEQKRNKQLEEKKHAMQETKIKGE 407
Query: 223 KAEQM-------EYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISA 275
K EQ E + Q L+ A + + R+ + E+ K E+
Sbjct: 408 KVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEK 467
Query: 276 HGKELFVNADLYIVAGRRYGLV---GPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVV 332
K+ ++ R+ G NG+ T LKH N V E
Sbjct: 468 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE---- 523
Query: 333 ADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAK 392
A+ P V+A R LEE RR +G+ E +E EK+ ++ + E K
Sbjct: 524 AEGAPQVEAGKR--------LEELRRRRGETE------SEEFEKLKQKQQEAALELEELK 569
Query: 393 ARRILAGLGFDPEMQNRPTQK 413
+R + E Q R ++
Sbjct: 570 KKREERRKVLEEEEQRRKQEE 590
Score = 54.7 bits (130), Expect = 3e-07
Identities = 83/407 (20%), Positives = 173/407 (42%), Gaps = 47/407 (11%)
Query: 2 PKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQ-AGEEEKVLK 60
PK +++ + I E DK + ++ + + A +DK+ A E ++
Sbjct: 238 PKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDD----DGEEK---ELMERLKKLSVPTSDEED 113
E++ Q++++++ ++R+ + K+ ++ EEK E +R+K+ ++E
Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 357
Query: 114 EVPAPKPRGG---KKTKGGNVFAALIQDQSEEEE-EEEKHPPKPAKPEKNRI-------- 161
+ + R ++ + A +++Q ++ EE+KH + K + ++
Sbjct: 358 RIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKW 417
Query: 162 ---NKAVSEEQQPALKGKKGKEEKSKGKAKPQ--NKFAALDNEEEDKEEEIIKEKEPPKQ 216
KA ++ Q A+ K+G+E+ +K +AK + + +EE K+E+I K+KEP ++
Sbjct: 418 VNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEE 477
Query: 217 GK---EKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSI 273
K ++ K +++ + EN FS S E A ++ K
Sbjct: 478 VKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGK--- 534
Query: 274 SAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVA 333
L + RR G + LK A + E+ V
Sbjct: 535 -----------RLEELRRRR----GETESEEFEKLKQKQQEAALELEELKKKREERRKVL 579
Query: 334 DETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEE 380
+E + AD ++L+ EE+RRL+ ++E+ AAE+ +K+ E+
Sbjct: 580 EEEEQRRKQEEAD-RKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 625
Score = 47.0 bits (110), Expect = 7e-05
Identities = 56/232 (24%), Positives = 102/232 (43%), Gaps = 19/232 (8%)
Query: 28 VKKGKKDKKIK-KTFFEELAVEDK-------QAGEEEKVLKEKEQQQQQQQQQQKKKRDT 79
+K K ++KI+ K E+ A EDK + GEE+ + ++++ Q+ + KK +
Sbjct: 404 IKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEI 463
Query: 80 RKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKT---KGGNVFAALI 136
+ + KKD + E K M+R KK + E K + + T GG
Sbjct: 464 KDEKIKKDKEPKEEVKSFMDR-KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV--- 519
Query: 137 QDQSEEEEEEEKHPPKPAKPEKNRINKAVSEE-QQPALKGKKGKEEKSKGKAKPQNKFAA 195
D E E + K + + R + SEE ++ K ++ E + K K + +
Sbjct: 520 -DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 578
Query: 196 LDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFS 247
L+ EE+ +++E K ++ +EK + E++E R A+ K E+ S
Sbjct: 579 LEEEEQRRKQEEADRKL--REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLS 628
Score = 45.1 bits (105), Expect = 3e-04
Identities = 58/285 (20%), Positives = 118/285 (41%), Gaps = 25/285 (8%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
+ +A ++Q I D + PS ++ +++ +K E E + E E V K
Sbjct: 111 LQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTK 170
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
++ + ++ KK+ K+ +++ EEK + + V EE + +
Sbjct: 171 SYQKNDWRDAEENKKE--------DKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEE 222
Query: 121 RGGKKTKGGNVFAALIQDQSEEEE--EEEKHPPKPAKPEKNRIN------KAVSEEQQPA 172
K G + + + + E E+ +E H K + +K R +A E+ A
Sbjct: 223 TVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA 282
Query: 173 LKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQME---Y 229
+ KK +E+++ +A + K AA + E + EE +E + +E+ + E+ +
Sbjct: 283 EQDKKIADERARIEA--EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAE 340
Query: 230 ERQVASLKAANAAENDFSVSQAEMSS----RQAMLENASDIKLEK 270
ERQ + AAE + + E + ++A E K+E+
Sbjct: 341 ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEE 385
Score = 42.0 bits (97), Expect = 0.002
Identities = 73/374 (19%), Positives = 161/374 (43%), Gaps = 21/374 (5%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDD 91
++ K+ + E + +EE+ +E+ ++ +Q++ +QK++ ++ G+ V+ +
Sbjct: 11 RRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQVTDQVEVN 69
Query: 92 GEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKK--TKGGNVFAALIQDQSEEEEEEEKH 149
+ E K + T E D+ A R ++ + + AL + + + +
Sbjct: 70 AQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDAS 129
Query: 150 PPKPAKPEKNRI--NKAVSEEQQPALKGKKGKEEKSKGKAKPQNK---FAALDNEEEDKE 204
P++ +N N+ +E++ + ++ + E+++ K K A +N++EDKE
Sbjct: 130 LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKE 189
Query: 205 EEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENAS 264
+E +E+E PK+G + E M E+ S + S+ ++SS + E
Sbjct: 190 KE-EEEEEKPKRGSIGENQVEVMVEEKTTESQEETVV----MSLKNGQISSEEPKQEEER 244
Query: 265 DIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDV 324
+ ++ S H +++ A R + K K IA+ I
Sbjct: 245 EQGSDEIS---HHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA 301
Query: 325 LLCEQE-VVADETPAV-QAVLRADTKRLKLLEEERRL---QGQLEQGDDTAAERLEKVYE 379
E+E A+E + + RA +R ++ EEE+R + ++++ + AAE +++ E
Sbjct: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE 361
Query: 380 ELRATGAAAAEAKA 393
E + A+A
Sbjct: 362 EEKRAAEERQRARA 375
Score = 36.2 bits (82), Expect = 0.12
Identities = 27/106 (25%), Positives = 57/106 (53%), Gaps = 9/106 (8%)
Query: 18 GESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKR 77
GE+ S + +K+ +++ ++ EEL K+ E KVL+E+EQ+++Q++ +K +
Sbjct: 544 GETESEEFEKLKQKQQEAALE---LEELK---KKREERRKVLEEEEQRRKQEEADRKLRE 597
Query: 78 DTRKGRRKKDVDDDGEEKELMERLKKLSVP-TSDEEDEVPAPKPRG 122
+ K R K+++ + E E+ +K+ SD++ P+G
Sbjct: 598 EEEKRRLKEEI--ERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 641
Score = 30.4 bits (67), Expect = 6.8
Identities = 21/72 (29%), Positives = 41/72 (56%), Gaps = 2/72 (2%)
Query: 498 FKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTK-EALTRKQQKCRRKNQDEE 556
F+K+ +QKQ+E + E+ +KK +E + + +Q KQ + + R++++ RR ++ E
Sbjct: 551 FEKL-KQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE 609
Query: 557 SQEAPELLKRPK 568
+ A KR K
Sbjct: 610 RRRAEAAEKRQK 621
>gi|4557509 cylicin 2 [Homo sapiens]
Length = 348
Score = 60.5 bits (145), Expect = 6e-09
Identities = 54/221 (24%), Positives = 97/221 (43%), Gaps = 28/221 (12%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
+ T+ S+ +K+GKKD K K D + G+EEK+ +K+ ++ ++ ++ K
Sbjct: 125 KDTTDSESELKQGKKDSKKGK---------DIEKGKEEKLDAKKDSKKGKKDAEKGKDSA 175
Query: 79 TR----KGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAA 134
T KG KKD + ++K+ + K + + E+ +G K +K G A
Sbjct: 176 TESEDEKGGAKKD---NKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAI 232
Query: 135 LIQDQSEEEEEEEK--------HPPKPAKPEKNRINKAVSEEQQPALKGKKGKE----EK 182
+Q +E+++E K AK + I K ++++P+ K+ E
Sbjct: 233 ELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKES 292
Query: 183 SKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKK 223
K K K A D E+E + + +K K K+ AKK
Sbjct: 293 KKDATKDAKKVAKKDTEKESADSKKDAKKNAKKDAKKDAKK 333
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/260 (20%), Positives = 105/260 (40%), Gaps = 27/260 (10%)
Query: 20 STSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDT 79
S PS + + + K + + A E + GE++ K+ + + +Q K+D+
Sbjct: 85 SERPSVYLAARRQPLKPTRTVEVDSKAAEIGKKGEDKTTQKDTTDSESELKQG---KKDS 141
Query: 80 RKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQ 139
+KG KD++ EEK ++ K +G K + G A +D+
Sbjct: 142 KKG---KDIEKGKEEKLDAKKDSK-----------------KGKKDAEKGKDSATESEDE 181
Query: 140 SEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNE 199
+++ K K + K+ ++ E+ KKGK++ KGK A +E
Sbjct: 182 KGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADE 241
Query: 200 EEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQAM 259
++D++ +K+ K + K K + E ++ K ++ ++D + S + A
Sbjct: 242 KKDED----GKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDAT 297
Query: 260 LENASDIKLEKFSISAHGKE 279
+ K + SA K+
Sbjct: 298 KDAKKVAKKDTEKESADSKK 317
Score = 35.0 bits (79), Expect = 0.28
Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 9/95 (9%)
Query: 16 GDGESTSPSD-KVVKKGKKDKKIKKTFFEELAVED------KQAGEEEKVLKEKEQQQQQ 68
GD + D K +KKGKKDKK K + + + +D K A ++ K + +K+ +++
Sbjct: 254 GDESKDAKKDAKEIKKGKKDKK-KPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKES 312
Query: 69 QQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKK 103
++ K++ +K KKD + ++ E + KK
Sbjct: 313 ADSKKDAKKNAKKD-AKKDAKKNAKKDEKKDAKKK 346
Score = 30.8 bits (68), Expect = 5.2
Identities = 36/159 (22%), Positives = 69/159 (43%), Gaps = 29/159 (18%)
Query: 24 SDKVVKKGKKD-KKIKKTFFEELAVE-----DKQAGEEEKVLKEKEQQQQQQQQQQKKKR 77
++K KKGKKD KK K + E AV+ D+ ++ E + ++ ++ +K K+
Sbjct: 213 TEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKK 272
Query: 78 DTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ 137
D +KK D + K+ V ++D K K T+ +
Sbjct: 273 D-----KKKPSSTDSDSKD--------DVKKESKKDATKDAKKVAKKDTE---------K 310
Query: 138 DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGK 176
+ ++ +++ +K+ K AK + + N E++ KGK
Sbjct: 311 ESADSKKDAKKNAKKDAKKDAKK-NAKKDEKKDAKKKGK 348
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 60.5 bits (145), Expect = 6e-09
Identities = 57/236 (24%), Positives = 108/236 (45%), Gaps = 20/236 (8%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
++ S KV K KKD K KK ++ D ++G+ + K+ ++ +++ ++ KKK D
Sbjct: 305 DAKKDSKKVKKNVKKDDK-KKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKK-D 362
Query: 79 TRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQD 138
T+K D + G+ K+ + L + +++ + A K ++ +
Sbjct: 363 TKKYPESTDTES-GDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSES--------EL 413
Query: 139 QSEEEEEEEKHPPKPAKPEKNRINKAVSE----EQQPALKGKKGKEEKSKGK---AKPQN 191
+S+E +++EK K +K + + K E + +P KKGK+++ KGK K
Sbjct: 414 ESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDK 473
Query: 192 KFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFS 247
K A N E + E ++ K+ K KE KK + + ++ + AE D S
Sbjct: 474 KKDAKKNAESTEMESDLELKKDKKHSKE--KKGSKKDIKKDARKDTESTDAEFDES 527
Score = 44.3 bits (103), Expect = 5e-04
Identities = 46/214 (21%), Positives = 93/214 (43%), Gaps = 27/214 (12%)
Query: 17 DGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKK 76
D ES S + K KKDKK KT ++ D+++ + + + K ++ ++ ++K K
Sbjct: 408 DSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADS--EPKGDSKKGKKDEKKGK 465
Query: 77 RDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALI 136
+D++K +KKD + E E+ L+ ++D+ + + +G KK +
Sbjct: 466 KDSKKDDKKKDAKKNAESTEMESDLEL-------KKDKKHSKEKKGSKKDIKKDA----- 513
Query: 137 QDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALK-GKKGKEEKSKGKAKPQNKFAA 195
+ +E + E K +I + +E ++ K G K K ++S G +K
Sbjct: 514 RKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDG-TSANSKMEG 572
Query: 196 LDNEE-----------EDKEEEIIKEKEPPKQGK 218
L+++ +K E+ + PP + K
Sbjct: 573 LESKRGFRMSSKKTTFNEKGEKASTGRVPPSREK 606
Score = 43.5 bits (101), Expect = 8e-04
Identities = 47/217 (21%), Positives = 84/217 (38%), Gaps = 15/217 (6%)
Query: 16 GDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKK 75
GD + + +KK K+ KK A + + + E L+ KE Q+ +++ ++
Sbjct: 375 GDAKDARNDSRNLKKASKNDDKKKD-----AKKITFSTDSESELESKESQKDEKKDKKDS 429
Query: 76 KRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAAL 135
K D +K + + D + + + K ++D K + KK A
Sbjct: 430 KTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKN------AES 483
Query: 136 IQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAA 195
+ +S+ E +++K K K K I K ++ + +E SK K K
Sbjct: 484 TEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTEST---DAEFDESSKTGFKTSTKIKG 540
Query: 196 LDNE-EEDKEEEIIKEKEPPKQGKEKAKKAEQMEYER 231
D E EE + K+K G K E +E +R
Sbjct: 541 SDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKR 577
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/187 (20%), Positives = 93/187 (49%), Gaps = 1/187 (0%)
Query: 50 KQAGEEEKVLKEKEQQQQQQQQQQKKKRDTR-KGRRKKDVDDDGEEKELMERLKKLSVPT 108
++ E +K +E+E++++++++++K++R + K +RKK E++ ER K+
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90
Query: 109 SDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEE 168
E + K + +K +G + + E E +++ K K K + K E
Sbjct: 91 EKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKRE 150
Query: 169 QQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQME 228
++ + +K K+ K + + K + + +E +++E ++KE K+ ++K ++ + +
Sbjct: 151 KERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRK 210
Query: 229 YERQVAS 235
+RQ S
Sbjct: 211 TDRQTDS 217
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/204 (22%), Positives = 100/204 (49%), Gaps = 30/204 (14%)
Query: 29 KKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDV 88
KK +++++ +K E ++ G++EK ++K ++ +++++++K++ RK RR+K+
Sbjct: 37 KKERREREKRKR--EREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKER 94
Query: 89 DDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEK 148
+EK+ ER K RG ++ K + + +E E E
Sbjct: 95 RKRKKEKKKRER------------------KQRGRRERK---------KKKERKEREREN 127
Query: 149 HPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEII 208
+ K +K R K E ++ +GK+ ++ K K K + + K + +E KE E
Sbjct: 128 KQRRERKRKKRRKKKRRKERKREKERGKRERKRK-KRKKEEREKKRERNRKERKKERERK 186
Query: 209 KEKEPPKQGKEKAKKAEQMEYERQ 232
+ +E K+ K++ +K ++ + +R+
Sbjct: 187 ERRERKKERKKERRKKKERKKDRK 210
Score = 43.9 bits (102), Expect = 6e-04
Identities = 34/142 (23%), Positives = 74/142 (52%), Gaps = 10/142 (7%)
Query: 29 KKGKKDKKIKKTFFEELAVEDKQAGEEE-KVLKEKEQQQQQQQQQQKKKRDTRKGRRKKD 87
+K +++K+ +K E+ E KQ G E K KE+++++++ +Q++++KR +K R+KK
Sbjct: 86 RKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKR--KKRRKKKR 143
Query: 88 VDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEE 147
+ EKE +R +K +E ++ + KK + +++ E ++E +
Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERER-------KERRERKKERK 196
Query: 148 KHPPKPAKPEKNRINKAVSEEQ 169
K K + +K+R ++ Q
Sbjct: 197 KERRKKKERKKDRKTDRQTDSQ 218
Score = 43.5 bits (101), Expect = 8e-04
Identities = 31/134 (23%), Positives = 57/134 (42%), Gaps = 13/134 (9%)
Query: 137 QDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAAL 196
Q +SE ++E + + + EK R K ++GK+EK K K + + K
Sbjct: 31 QRESERKKERREREKRKREREKER-------------KRERGKKEKKKRKKRERGKERER 77
Query: 197 DNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSR 256
+E +K+ + +EKE K+ KEK K+ + R+ K E + + +
Sbjct: 78 KRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKK 137
Query: 257 QAMLENASDIKLEK 270
+ + + K EK
Sbjct: 138 RRKKKRRKERKREK 151
Score = 36.2 bits (82), Expect = 0.12
Identities = 21/71 (29%), Positives = 40/71 (56%), Gaps = 6/71 (8%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
+K ++K+K KQ ++E+K K K K+ E++ K+ RK++K R+K + +E +
Sbjct: 95 RKRKKEKKKRERKQRGRRERKKK------KERKERERENKQRRERKRKKRRKKKRRKERK 148
Query: 559 EAPELLKRPKE 569
E KR ++
Sbjct: 149 REKERGKRERK 159
Score = 35.8 bits (81), Expect = 0.16
Identities = 17/71 (23%), Positives = 43/71 (60%)
Query: 29 KKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDV 88
K+ +K KK KK E+ +++ ++E+ KE+ +++++++++++KK++ +K R+
Sbjct: 155 KRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQ 214
Query: 89 DDDGEEKELME 99
D + L E
Sbjct: 215 TDSQVFRPLRE 225
Score = 34.7 bits (78), Expect = 0.36
Identities = 15/60 (25%), Positives = 37/60 (61%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
+K ++++KE ++ K+EKK ++ + GK ++ K+ ++ +++K RRK + E+ +
Sbjct: 44 EKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKK 103
Score = 34.7 bits (78), Expect = 0.36
Identities = 21/81 (25%), Positives = 46/81 (56%), Gaps = 3/81 (3%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQ---QQKKKRDTRK 81
+K ++ K+ K+ KK +E E ++ E K K K+++++++++ +++KK RK
Sbjct: 127 NKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERK 186
Query: 82 GRRKKDVDDDGEEKELMERLK 102
RR++ + E ++ ER K
Sbjct: 187 ERRERKKERKKERRKKKERKK 207
Score = 34.7 bits (78), Expect = 0.36
Identities = 18/75 (24%), Positives = 47/75 (62%), Gaps = 1/75 (1%)
Query: 29 KKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDV 88
++GK+++K KK EE + ++ +E K +E++++++++++ +KK+R +K R+K
Sbjct: 152 ERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKE-RKKERRKKKERKKDRK 210
Query: 89 DDDGEEKELMERLKK 103
D + ++ L++
Sbjct: 211 TDRQTDSQVFRPLRE 225
Score = 32.3 bits (72), Expect = 1.8
Identities = 18/71 (25%), Positives = 39/71 (54%), Gaps = 5/71 (7%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
KK ++KQ+ ++ +K+E+K +E + KQ ++ ++ +K+++ RK + E +
Sbjct: 101 KKKRERKQRGRRERKKKKERKERE-----RENKQRRERKRKKRRKKKRRKERKREKERGK 155
Query: 559 EAPELLKRPKE 569
+ KR KE
Sbjct: 156 RERKRKKRKKE 166
Score = 32.0 bits (71), Expect = 2.4
Identities = 17/74 (22%), Positives = 42/74 (56%), Gaps = 1/74 (1%)
Query: 159 NRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGK 218
+ I+K ++ + K ++ +E++ + + K + + +++ K+ E KE+E ++ +
Sbjct: 23 SHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKER 82
Query: 219 EKAKKAEQMEYERQ 232
EK +K E+ E ER+
Sbjct: 83 EKQRK-ERREKERR 95
Score = 31.6 bits (70), Expect = 3.1
Identities = 20/78 (25%), Positives = 43/78 (55%), Gaps = 3/78 (3%)
Query: 492 RGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRK 551
RG K+ +++ KE ++ +++EK+ KE + + ++ EK+ +E RKQ+ R +
Sbjct: 58 RGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRE---RKQRGRRER 114
Query: 552 NQDEESQEAPELLKRPKE 569
+ +E +E K+ +E
Sbjct: 115 KKKKERKERERENKQRRE 132
Score = 31.6 bits (70), Expect = 3.1
Identities = 19/72 (26%), Positives = 41/72 (56%), Gaps = 2/72 (2%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAE--KQTKEALTRKQQKCRRKNQDEE 556
+K ++K+++ K+ K+E+K K+ K + K+ K+ K+ RK+++ R+K + +E
Sbjct: 139 RKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKE 198
Query: 557 SQEAPELLKRPK 568
++ E K K
Sbjct: 199 RRKKKERKKDRK 210
Score = 31.2 bits (69), Expect = 4.0
Identities = 17/67 (25%), Positives = 38/67 (56%), Gaps = 1/67 (1%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 562
++K++ ++ K+E++ + + GK K+ K+ + R++++ R+ Q +E +E E
Sbjct: 35 ERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERRE-KE 93
Query: 563 LLKRPKE 569
KR KE
Sbjct: 94 RRKRKKE 100
Score = 31.2 bits (69), Expect = 4.0
Identities = 17/84 (20%), Positives = 43/84 (51%)
Query: 486 QRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQ 545
+R R N ++ ++++K+ ++ K+EK+ + + K K+ E++ K RK+
Sbjct: 119 ERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKE 178
Query: 546 QKCRRKNQDEESQEAPELLKRPKE 569
+K R+ ++ ++ +R K+
Sbjct: 179 RKKERERKERRERKKERKKERRKK 202
Score = 30.8 bits (68), Expect = 5.2
Identities = 19/71 (26%), Positives = 40/71 (56%), Gaps = 3/71 (4%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
KK ++K++E + +++E+K K K K ++ K+ KE R++++ +RK ++ E +
Sbjct: 115 KKKKERKERER-ENKQRRERKRK--KRRKKKRRKERKREKERGKRERKRKKRKKEEREKK 171
Query: 559 EAPELLKRPKE 569
+R KE
Sbjct: 172 RERNRKERKKE 182
Score = 30.4 bits (67), Expect = 6.8
Identities = 15/67 (22%), Positives = 38/67 (56%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 562
+++++E K+ ++E+K + K K K+ E+ + RK+++ +RK + E+ + +
Sbjct: 39 ERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRK 98
Query: 563 LLKRPKE 569
K+ +E
Sbjct: 99 KEKKKRE 105
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 59.7 bits (143), Expect = 1e-08
Identities = 45/154 (29%), Positives = 78/154 (50%), Gaps = 31/154 (20%)
Query: 33 KDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDG 92
K KK KK EE ++ EEEK K KE++++++++++KKK+ T++ ++K+ +++
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKK-TKETEKRKEKEEE- 58
Query: 93 EEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPK 152
E+K +R KK +EE+E ++ EE+EEEEK +
Sbjct: 59 EKKRKRKRKKKKEEEEREEEEE-----------------------EEEEEKEEEEKEEGR 95
Query: 153 PAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGK 186
K +K R K EE+ KK + K+K K
Sbjct: 96 RRKKKKKRRRKEEEEEK------KKKRRRKTKKK 123
Score = 57.8 bits (138), Expect = 4e-08
Identities = 31/96 (32%), Positives = 54/96 (56%)
Query: 137 QDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAAL 196
++ E EEEEEK + K ++ R K ++ + K K+ +EE+ K K K + K
Sbjct: 14 EETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEE 73
Query: 197 DNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
+ EEE++EEE KE+E ++G+ + KK ++ E +
Sbjct: 74 EREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEE 109
Score = 49.3 bits (116), Expect = 1e-05
Identities = 38/156 (24%), Positives = 78/156 (50%), Gaps = 34/156 (21%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
K K++ E E + E T ++ K+GK+ +K K E ++ E++K KE
Sbjct: 1 KKKKKKKKETEETEETEETEEEEE--KEGKRKEKRK---------EKRKEKEKKKKTKET 49
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
E++++++++++K+KR +K + +++ +++ EE+E +E++E + R
Sbjct: 50 EKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEE-------------EEKEEEEKEEGRR 96
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEK 158
KK K + +EEEEEK + K +K
Sbjct: 97 RKKKK----------KRRRKEEEEEKKKKRRRKTKK 122
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/151 (21%), Positives = 72/151 (47%), Gaps = 36/151 (23%)
Query: 56 EKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEV 115
+K K+K++ ++ ++ ++ ++ + ++G+RK+ + +EKE ++ K+ EE+E
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 116 PAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKG 175
+ R KK + +++ EEEEEEE+
Sbjct: 61 KRKRKRKKKKEE---------EEREEEEEEEEE--------------------------- 84
Query: 176 KKGKEEKSKGKAKPQNKFAALDNEEEDKEEE 206
+K +EEK +G+ + + K EEE+K+++
Sbjct: 85 EKEEEEKEEGRRRKKKKKRRRKEEEEEKKKK 115
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/81 (28%), Positives = 40/81 (49%)
Query: 152 KPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEK 211
K K E + E++ +GK+ ++ K K K K + K + ++KEEE K K
Sbjct: 4 KKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRK 63
Query: 212 EPPKQGKEKAKKAEQMEYERQ 232
K+ KE+ ++ E+ E E +
Sbjct: 64 RKRKKKKEEEEREEEEEEEEE 84
Score = 41.2 bits (95), Expect = 0.004
Identities = 21/101 (20%), Positives = 60/101 (59%), Gaps = 2/101 (1%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
K K++ E + E + + K+ +K+++ KK + ++++ EEE+ +E+
Sbjct: 25 KEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEE--EEE 82
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKK 103
E++++++++++ ++R +K RR+K+ +++ ++K + KK
Sbjct: 83 EEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKTKKK 123
Score = 38.9 bits (89), Expect = 0.019
Identities = 20/65 (30%), Positives = 37/65 (56%)
Query: 505 KQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELL 564
K+KE K+ K+++K K+ K K ++ E++ K RK++K + ++EE +E E
Sbjct: 28 KRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKE 87
Query: 565 KRPKE 569
+ KE
Sbjct: 88 EEEKE 92
Score = 37.0 bits (84), Expect = 0.073
Identities = 18/87 (20%), Positives = 47/87 (54%)
Query: 146 EEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEE 205
++K K E + EE++ + +K KE++ + + K + K E+E++E+
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 206 EIIKEKEPPKQGKEKAKKAEQMEYERQ 232
+ ++++ K+ +E+ ++ E+ E E++
Sbjct: 61 KRKRKRKKKKEEEEREEEEEEEEEEKE 87
Score = 36.2 bits (82), Expect = 0.12
Identities = 22/80 (27%), Positives = 43/80 (53%), Gaps = 9/80 (11%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQ---------QKCR 549
K+ + ++ E ++ E++E K KE + + K+ +K+TKE RK+ +K +
Sbjct: 8 KETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRK 67
Query: 550 RKNQDEESQEAPELLKRPKE 569
+K ++EE +E E + KE
Sbjct: 68 KKKEEEEREEEEEEEEEEKE 87
Score = 35.8 bits (81), Expect = 0.16
Identities = 17/71 (23%), Positives = 43/71 (60%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
K+ ++++K K+ +K+E++ +E + + ++ E++ +E RK++K RR+ ++EE +
Sbjct: 53 KEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEK 112
Query: 559 EAPELLKRPKE 569
+ K K+
Sbjct: 113 KKKRRRKTKKK 123
Score = 35.4 bits (80), Expect = 0.21
Identities = 22/70 (31%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 500 KMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQE 559
K ++K+KE + E +E + +E K G + K+ EK+ KE +K+ K K +++E +E
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKR-KEKEKKKKTKETEKRKEKEEEE 59
Query: 560 APELLKRPKE 569
KR K+
Sbjct: 60 KKRKRKRKKK 69
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/71 (28%), Positives = 42/71 (59%), Gaps = 2/71 (2%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
K+ ++K+KE K+ ++ EK+ KE + K K+ K+ KE R++++ + +++E +
Sbjct: 32 KRKEKRKEKEKKKKTKETEKR-KEKEEEEKKRKRKRKKKKEEEEREEEE-EEEEEEKEEE 89
Query: 559 EAPELLKRPKE 569
E E +R K+
Sbjct: 90 EKEEGRRRKKK 100
Score = 32.0 bits (71), Expect = 2.4
Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 2/99 (2%)
Query: 174 KGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKE--KAKKAEQMEYER 231
K KK KE + + + + + + ++K +E KEKE K+ KE K K+ E+ E +R
Sbjct: 3 KKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKR 62
Query: 232 QVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEK 270
+ K E + + E + E K +K
Sbjct: 63 KRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKK 101
Score = 31.6 bits (70), Expect = 3.1
Identities = 15/71 (21%), Positives = 41/71 (57%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
K+ ++K+K+ + +++EK+ +E K K K+ E++ +E ++++ + + + EE +
Sbjct: 36 KRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGR 95
Query: 559 EAPELLKRPKE 569
+ KR ++
Sbjct: 96 RRKKKKKRRRK 106
Score = 30.8 bits (68), Expect = 5.2
Identities = 14/70 (20%), Positives = 43/70 (61%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
+K +++++E ++ ++++KK +E + + ++ EK+ +E +++K ++K + +E +
Sbjct: 50 EKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEE 109
Query: 559 EAPELLKRPK 568
E + +R K
Sbjct: 110 EEKKKKRRRK 119
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 59.3 bits (142), Expect = 1e-08
Identities = 52/224 (23%), Positives = 109/224 (48%), Gaps = 12/224 (5%)
Query: 6 KQQPPEPEWIG-DGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQ 64
K+ + EW DGE ++ ++G + ++ ++ EE E+ GEEE+ +E+E+
Sbjct: 694 KELAEKEEWKKRDGEEQEQKER--EQGHQKERNQE--MEEGGEEEHGEGEEEEGDREEEE 749
Query: 65 QQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGK 124
+++ + +++ + + R K++ + EE+ E + + E+E + RG +
Sbjct: 750 EKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEE--ETEGRGEE 807
Query: 125 KTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSK 184
K +GG V +++ E EEEE+ + + + EE++ KG+EE +
Sbjct: 808 KEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGE---GKGEEEGEE 864
Query: 185 GKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQME 228
G+ + + + + EEE+ E E E+E +G+E+ + E E
Sbjct: 865 GEGEEEGEEGEGEGEEEEGEGE--GEEEGEGEGEEEEGEGEGEE 906
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/228 (25%), Positives = 107/228 (46%), Gaps = 32/228 (14%)
Query: 12 PEWIGDGESTSPS-------DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQ 64
PE GDG S D+ +KG+KDK E ++ GE EK L EKE+
Sbjct: 651 PEGRGDGTCEEGSSGAEHWQDEEREKGEKDKG---------RGEMERPGEGEKELAEKEE 701
Query: 65 QQQQ--QQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
+++ ++Q+QK++ + R +++++ GEE E E ++ +EE E +
Sbjct: 702 WKKRDGEEQEQKEREQGHQKERNQEMEEGGEE-EHGEGEEEEGDREEEEEKEGEGKEEGE 760
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEK 182
G++ +G + E+EE E K + K EK E ++ +G+ G+E++
Sbjct: 761 GEEVEG----------EREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGR-GEEKE 809
Query: 183 SKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYE 230
G+ + EE++EE +E+E +G+E+ + E+ E E
Sbjct: 810 EGGEVEGGEVEEGKGEREEEEEEGEGEEEE--GEGEEEEGEGEEEEGE 855
Score = 56.2 bits (134), Expect = 1e-07
Identities = 49/194 (25%), Positives = 95/194 (48%), Gaps = 10/194 (5%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
EE+ + +++ G E+ E+Q+ + ++ K RK + + DD ++ E+ E
Sbjct: 582 EEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKA 641
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
K + ED P+ RG + G+ A QD+ E+ E++K + +P +
Sbjct: 642 K---SVGEAED---GPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKE 695
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEE---EDKEEEIIKEKEPPKQGKE 219
A EE + ++ ++E+ +G K +N+ EE E +EEE +E+E K+G+
Sbjct: 696 LAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEG 755
Query: 220 KAK-KAEQMEYERQ 232
K + + E++E ER+
Sbjct: 756 KEEGEGEEVEGERE 769
Score = 52.4 bits (124), Expect = 2e-06
Identities = 55/258 (21%), Positives = 117/258 (45%), Gaps = 17/258 (6%)
Query: 11 EPEWIGDGESTSPSDKV----VKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQ 66
E E G GE +V V++GK +++ ++ E E++ GEEE+ E+E+ +
Sbjct: 798 EEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE--EGEGEEEEGEGEEEEGEGEEEEGE 855
Query: 67 QQQQQQQKKKRDTRKGRR------KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
+ +++ ++ +G +++ + +GEE+ E ++ +EE E +
Sbjct: 856 GKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEE 915
Query: 121 RG-GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGK 179
G GK + G + + EEEE E + + E+ EE+ ++G+
Sbjct: 916 EGEGKGEEEGEEG----EGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGE 971
Query: 180 EEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAA 239
E +G+ + + + + EEE+ EEE +E E ++G+ + ++ E+ E E +V +
Sbjct: 972 GEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGE 1031
Query: 240 NAAENDFSVSQAEMSSRQ 257
E + + E ++
Sbjct: 1032 GEGEEEEGEEEGEEREKE 1049
Score = 47.8 bits (112), Expect = 4e-05
Identities = 48/205 (23%), Positives = 89/205 (43%), Gaps = 21/205 (10%)
Query: 24 SDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGR 83
SD + K + + K+ E ED G + +E + Q ++++K + KGR
Sbjct: 627 SDDLTDKAEVSEGKAKSVGE---AEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGR 683
Query: 84 RKKDVDDDGEEKELMER---LKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQS 140
+ + +GE KEL E+ K+ +E E K R + +GG +++
Sbjct: 684 GEMERPGEGE-KELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGG-------EEEH 735
Query: 141 EEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEE 200
E EEEE + + E + EE + G+ EK +G+ K + + + E
Sbjct: 736 GEGEEEEGDREEEEEKEGEGKEEGEGEEVE-------GEREKEEGERKKEERAGKEEKGE 788
Query: 201 EDKEEEIIKEKEPPKQGKEKAKKAE 225
E+ ++ +E+E +G+EK + E
Sbjct: 789 EEGDQGEGEEEETEGRGEEKEEGGE 813
Score = 43.9 bits (102), Expect = 6e-04
Identities = 54/222 (24%), Positives = 99/222 (44%), Gaps = 37/222 (16%)
Query: 11 EPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQA-GEEEKVLKEKEQQQQQQ 69
E E G+GE K ++G++ + + E ED + GEEE+ E E+++ +
Sbjct: 905 EEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEG 964
Query: 70 QQQQKKKRDTRKGR---RKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKT 126
+ +++ + + +G +++ + +GEE+E E +EE E G++
Sbjct: 965 EGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEE--------GEEEGEGEEEGEGEGEEE 1016
Query: 127 KGGNVFAALIQDQSEEE------EEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
+ G V + ++ E E EEE + K + E+NR N+ EE++ + + G+E
Sbjct: 1017 EEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQ-ETGEE 1075
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEE--EIIKEKEPPKQGKEK 220
E NE +D EE ++ K K K GK K
Sbjct: 1076 E----------------NERQDGEEYKKVSKIKGSVKYGKHK 1101
Score = 43.1 bits (100), Expect = 0.001
Identities = 42/199 (21%), Positives = 96/199 (48%), Gaps = 4/199 (2%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRK-KDVDDDGEEKE-LMER 100
EE E ++ GE E +E E + +++ ++ + + + +G + +D + +GEE+E E
Sbjct: 898 EEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEG 957
Query: 101 LKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNR 160
++ +EE E + G + + G + + E EEE E + E+
Sbjct: 958 EEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017
Query: 161 INKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEK 220
+ E + +G +G+EE+ + + + + K + ++EEE +E + + G+E+
Sbjct: 1018 EGEVEGEVEGEEGEG-EGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEE 1076
Query: 221 AKKAEQMEYERQVASLKAA 239
++ + EY ++V+ +K +
Sbjct: 1077 NERQDGEEY-KKVSKIKGS 1094
>gi|27734775 hypothetical protein LOC286499 [Homo sapiens]
Length = 248
Score = 59.3 bits (142), Expect = 1e-08
Identities = 53/215 (24%), Positives = 95/215 (44%), Gaps = 16/215 (7%)
Query: 32 KKDKKIKKTFFEELA-VEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDD 90
KK + KKT + LA E+K +K L++ ++ + KKR+ +K R+KK
Sbjct: 45 KKQLENKKTGSKALAEFEEKMNENWKKELEKSREKLLSGNESSSKKRERKKKRKKKSCRS 104
Query: 91 DGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHP 150
S +SD EDE K +G ++ K N Q + E E E K
Sbjct: 105 SSSSSS-----SDSSSSSSDSEDE---EKKQGKRRKKKKNRSYKSSQSSTHESESESKES 156
Query: 151 PKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNE-EEDKEEEIIK 209
K K K+ E++ ++ K +KS KP + ++ +++ EED + + +
Sbjct: 157 VKKKKKSKDET------EKEKDVRSLSKKRKKSYPDDKPLSSESSSESDYEEDVQAKKKR 210
Query: 210 EKEPPKQGKEKAKKAEQMEYERQVASLKAANAAEN 244
E +Q KEK KK ++ ++++ K + + +
Sbjct: 211 RCEEREQAKEKVKKKKKKQHKKHSKKKKKKSGSSH 245
Score = 41.6 bits (96), Expect = 0.003
Identities = 40/165 (24%), Positives = 65/165 (39%), Gaps = 33/165 (20%)
Query: 20 STSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDT 79
S+ D+ K+GK+ KK K ++ ++ E K +K+++ + + +++K R
Sbjct: 117 SSDSEDEEKKQGKRRKKKKNRSYKSSQSSTHESESESKESVKKKKKSKDETEKEKDVRSL 176
Query: 80 RKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQ 139
K R+K DD + L S SD E++V A K R +
Sbjct: 177 SKKRKKSYPDD--------KPLSSESSSESDYEEDVQAKKKRRCE--------------- 213
Query: 140 SEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSK 184
E E+ +EK K K K K K K G KS+
Sbjct: 214 -EREQAKEKVKKKKKKQHKKHSKKK---------KKKSGSSHKSR 248
Score = 37.0 bits (84), Expect = 0.073
Identities = 29/148 (19%), Positives = 60/148 (40%), Gaps = 11/148 (7%)
Query: 142 EEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNK------FAA 195
E +++ K K + R + + S + EEK +GK + + K +
Sbjct: 85 ESSSKKRERKKKRKKKSCRSSSSSSSSDSSSSSSDSEDEEKKQGKRRKKKKNRSYKSSQS 144
Query: 196 LDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVA-----SLKAANAAENDFSVSQ 250
+E E + +E +K+K+ K EK K + +R+ + L + +++E+D+
Sbjct: 145 STHESESESKESVKKKKKSKDETEKEKDVRSLSKKRKKSYPDDKPLSSESSSESDYEEDV 204
Query: 251 AEMSSRQAMLENASDIKLEKFSISAHGK 278
R+ + K++K H K
Sbjct: 205 QAKKKRRCEEREQAKEKVKKKKKKQHKK 232
Score = 33.1 bits (74), Expect = 1.1
Identities = 21/71 (29%), Positives = 41/71 (57%), Gaps = 12/71 (16%)
Query: 515 KQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQE--APELLKRPKEYTV 572
+++KK + K+ ST ++E ++KE++ +K +K++DE +E L K+ K+
Sbjct: 131 RKKKKNRSYKSSQSSTHESESESKESVKKK-----KKSKDETEKEKDVRSLSKKRKK--- 182
Query: 573 RFTFPDPPPLS 583
++PD PLS
Sbjct: 183 --SYPDDKPLS 191
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 58.9 bits (141), Expect = 2e-08
Identities = 49/230 (21%), Positives = 114/230 (49%), Gaps = 37/230 (16%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK-EKEQ 64
++Q +W+ E T ++ +K +++K+ D++ E+ LK E+E+
Sbjct: 449 REQEERRDWLKREEETERHEQERRK----QQLKR---------DQEEERRERWLKLEEEE 495
Query: 65 QQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGK 124
+++QQ++++++ R ++ RR++ + EE+ L +RL+ ++E+ R +
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 125 KTKGGNVFAALIQDQSEE--EEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEK 182
K L Q++ E+ + E+E+ + K E+ R + + EQ+ L+ + +EE
Sbjct: 556 K--------RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEV 607
Query: 183 SKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
+ E+E++ E+ +K +EP ++ +++ K+E+ E RQ
Sbjct: 608 ER-------------LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ 644
Score = 57.0 bits (136), Expect = 7e-08
Identities = 98/544 (18%), Positives = 229/544 (42%), Gaps = 56/544 (10%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
+ L E+ + +++LK +EQ++++QQQ ++++++ R+ R K++ EE+E +E+
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE-----EEEERLEQRL 672
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
K E E+ + ++ + Q +SE + + K +P K E R
Sbjct: 673 KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR-R 731
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALD-------NEEEDKEEEIIKEKEPPK 215
+ EE++ + + +E+ + + Q + D E+ ++ + + + P +
Sbjct: 732 RQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLR 791
Query: 216 QGKEKAKKAEQMEY-------ERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKL 268
+ +E+ +AE+ + E + + E + + E + E A ++
Sbjct: 792 EQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Query: 269 EKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCE 328
E+ + +E + + R+ L + + TL A AL + L E
Sbjct: 852 EEDGLQ-EDQERRRSQEQRRDQKWRWQLEEERKRRRHTL---YAKPALQ-----EQLRKE 902
Query: 329 QEVVADETPAVQAVLRADTKRL---KLLEEERRLQGQLEQGDDTAAERLEKVYEELRATG 385
Q+++ +E +Q R +R + EE +LQ + EQ E+ + E +
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962
Query: 386 AAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLD 445
+ K ++ LG +PE + R ++ + L E L+ +E
Sbjct: 963 DKKLQQKEEQL---LGEEPEKRRRQERE------KKYREEEELQQEEEQLLREEREKR-- 1011
Query: 446 LNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQK 505
W Y RK + ++ L + + +RL Y +++ QQ+
Sbjct: 1012 -RRQEWERQY----RKKDELQQEEEQLLRE------EREKRRLQERERQYREEEEL-QQE 1059
Query: 506 QKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLK 565
+++LL + E++ ++ +EL+ + ++ +++ ++ L + +K RR+ ++ + +E EL +
Sbjct: 1060 EEQLLGE-ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ 1118
Query: 566 RPKE 569
++
Sbjct: 1119 EEEQ 1122
Score = 57.0 bits (136), Expect = 7e-08
Identities = 51/220 (23%), Positives = 109/220 (49%), Gaps = 22/220 (10%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGR-------- 83
+KDKK+++ + L E ++ +E+ K +E+++ QQ+++Q + + K R
Sbjct: 961 RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY 1020
Query: 84 RKKDVDDDGEEKELMERLKKLSVPTSD----EEDEVPAPKPR---GGKKTKGGNVFAALI 136
RKKD EE+ L E +K + + EE+E+ + + ++T+
Sbjct: 1021 RKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQY 1080
Query: 137 QDQSEEEEEEE----KHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNK 192
+ + E ++EEE + P K + E+ R + E QQ + + +EE+ K + + +
Sbjct: 1081 RKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE--EEQLLREEREKRRRQELER 1138
Query: 193 FAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
+ E + +EE++++E EP K+ +++ ++ + E E Q
Sbjct: 1139 QYREEEEVQQEEEQLLRE-EPEKRRRQELERQYREEEELQ 1177
Score = 53.5 bits (127), Expect = 8e-07
Identities = 109/589 (18%), Positives = 241/589 (40%), Gaps = 89/589 (15%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVK---KGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
K+Q E E + +GE S + ++ + ++D+++ + E E+++A EE+ +
Sbjct: 140 KRQEQERE-LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERL---------KKLSVPTSDEED 113
+ ++ ++Q ++R+ + RRK + + +E +R+ +K EE+
Sbjct: 199 HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258
Query: 114 EVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPAL 173
++ +P+ ++ +Q++ E+ + E+ + + E+ + + + EQQ
Sbjct: 259 KLQEEEPQRQRE----------LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR 308
Query: 174 KGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQ------- 226
K ++ + E+ + + + Q + + +EE +E+++ +E+E ++ + + ++ E+
Sbjct: 309 KQEEERREQQEERREQQER---REQQEERREQQLRREQEERREQQLRREQEEERREQQLR 365
Query: 227 --MEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNA 284
E ER+ L+ + + + + R+ L ++ E+ +L
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ--------QLRREQ 417
Query: 285 DLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLR 344
L RR + + + KH R L EQE D + R
Sbjct: 418 QL-----RREQQLRREQEEERHEQKHEQER------REQRLKREQEERRDWLKREEETER 466
Query: 345 ADTKR----LKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGL 400
+ +R LK +EE R + L+ ++ E+ E+ ++LR E + +R
Sbjct: 467 HEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR----- 521
Query: 401 GFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWR 460
E + R Q+ R L R L+ E L+ R
Sbjct: 522 ---QEEEERLQQRL----RSEQQLRREQEERREQLLKREEEKRLEQE------------R 562
Query: 461 KTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKL 520
+ + + D + QRL R ++ ++++ E L+Q E++E++L
Sbjct: 563 REQRLKREQEERRDQLLKREEERRQQRLK--REQEERLEQRLKREEVERLEQEERREQRL 620
Query: 521 KELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPKE 569
K + + +Q K ++E R+QQ+ RR+ Q+ Q LKR +E
Sbjct: 621 KREEPEEERRQQLLK-SEEQEERRQQQLRREQQERREQR----LKREEE 664
Score = 52.8 bits (125), Expect = 1e-06
Identities = 46/238 (19%), Positives = 117/238 (49%), Gaps = 14/238 (5%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
++ +++ +++K+ ++ + E++ EEE++L+E+ +++++Q+++++ ++D + ++
Sbjct: 910 EEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969
Query: 85 KKD-VDDDGEEKELMERLKKL--SVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSE 141
++ + ++ E++ ER KK EE+++ + ++ + + + Q E
Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 142 EEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEE 201
EE+ + K E+ R + E QQ +EE+ G+ + + L+ +
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQ--------EEEQLLGEERETRRRQELERQYR 1081
Query: 202 DKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQAM 259
KEEE+ +E+E + +E+ +K + E ERQ + E + E RQ +
Sbjct: 1082 -KEEELQQEEE--QLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Score = 52.8 bits (125), Expect = 1e-06
Identities = 41/237 (17%), Positives = 123/237 (51%), Gaps = 12/237 (5%)
Query: 2 PKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVL-K 60
P+ ++Q E ++ + E ++++++ +++K+ ++ + + +D+ EEE++L +
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLRE-EREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGE--EKELMERLKKLSVPTSDEEDEVPAP 118
E+E+++ Q++++Q ++ + + ++ + ++ E ++ +ER + EE+++
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 119 KPRGGKKTKGGNVFAALIQDQSEEEE---EEEKHPPKPAKPEKNRINKAVSEEQQPALKG 175
+P ++ + + Q EEE+ EE + + + R + V +E++ L
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL-- 1154
Query: 176 KKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
+EE K + + + + E + +EE++++E++ ++ + + + E+ E +RQ
Sbjct: 1155 ---REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208
Score = 50.4 bits (119), Expect = 6e-06
Identities = 48/230 (20%), Positives = 107/230 (46%), Gaps = 29/230 (12%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDD 91
+K++++ + EEL E+++ ++ ++ +++Q QQ++++ R+ R+ RR++
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ----- 954
Query: 92 GEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEE----EEEE 147
E + + KKL +E+++ +P ++ + + + Q EEE EE E
Sbjct: 955 -ERERQYRKDKKL----QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Query: 148 KHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEI 207
K + + + + ++ EE+Q +EE+ K + + + E + +EEE
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLL------REEREKRRLQ--------ERERQYREEEE 1055
Query: 208 IKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQ 257
++++E G+E+ + Q E ERQ + E + E RQ
Sbjct: 1056 LQQEEEQLLGEERETRRRQ-ELERQYRKEEELQQEEEQLLREEPEKRRRQ 1104
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/195 (22%), Positives = 95/195 (48%), Gaps = 18/195 (9%)
Query: 48 EDKQAGEEE---KVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKEL--MERLK 102
E++Q +E K L+E+ Q ++Q+++QQ + RK R ++ + +GEE++L ER +
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
K +EE ++ + + + ++ + EEE+ + + + R
Sbjct: 1692 KF----REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK 222
K + EEQ + +EE+ + + KF + +++EE+ ++ +E ++ +E+
Sbjct: 1748 KILEEEQL-----RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE-- 1800
Query: 223 KAEQMEYERQVASLK 237
EQ+ ER+ L+
Sbjct: 1801 --EQLRQEREEQQLR 1813
Score = 48.5 bits (114), Expect = 2e-05
Identities = 40/215 (18%), Positives = 110/215 (51%), Gaps = 19/215 (8%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDD 91
++ +++++ + EE E+ Q EE+ + +E+E+++Q++++Q +++ + ++ +RK+ D+
Sbjct: 1161 RRRQELERQYREE---EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE 1217
Query: 92 GEEKEL---MERLKKLSVPTSD------EEDEVPAPKPRGGKKTKGGNVFAALIQDQSEE 142
+ +L E K+ +V + E ++ + + + L+ +Q E
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277
Query: 143 EEEEEKHPPKPAK---PEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNE 199
+ E+E+ + PE+ ++ + E+++ + +K +EEK + + + K + +
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLER--EEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Query: 200 EEDKEEE--IIKEKEPPKQGKEKAKKAEQMEYERQ 232
+ +EEE + + +E P + +E+ +K + E Q
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Score = 47.4 bits (111), Expect = 5e-05
Identities = 45/219 (20%), Positives = 100/219 (45%), Gaps = 42/219 (19%)
Query: 31 GKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQ------QQQQQQQQKKKRDTRKGRR 84
G ++K + +E ++D++ E+++ + +++Q Q+++Q++Q+++R+ +G
Sbjct: 94 GLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE- 152
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEE 144
E+ E ERL++ DEE Q Q +E
Sbjct: 153 --------EQSEKQERLEQRDRQRRDEE---------------------LWRQRQEWQER 183
Query: 145 EEEKHPPKPAKPEKNRINKAVSEEQQPALK-----GKKGKEEKSKGKAKPQNK-FAALDN 198
EE + + + K + +E+Q + +KG+EEK + + + Q++ F +
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243
Query: 199 EEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLK 237
+E K E +++++E Q +E ++ E E E Q+ L+
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Score = 47.4 bits (111), Expect = 5e-05
Identities = 43/215 (20%), Positives = 103/215 (47%), Gaps = 20/215 (9%)
Query: 49 DKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPT 108
D++ EEE++L+E E+QQ ++Q++ +K R+ + R+++ + ++E R ++L
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF 1725
Query: 109 SDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEE 168
+EE + ++ + + +++++ E EE+ + + K R EE
Sbjct: 1726 REEEQ---LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFR------EE 1776
Query: 169 QQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQME 228
+Q ++ +EE+ + KF + +++EE+ ++ ++ + GK + ++ EQ++
Sbjct: 1777 EQL----RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQ--RDGKYRWEE-EQLQ 1829
Query: 229 YERQVASLKAAN----AAENDFSVSQAEMSSRQAM 259
E Q L+ AE F+ + Q +
Sbjct: 1830 LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864
Score = 45.1 bits (105), Expect = 3e-04
Identities = 36/212 (16%), Positives = 106/212 (50%), Gaps = 22/212 (10%)
Query: 8 QPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQ 67
Q E + +G+ T ++ ++ +K++++++ + L E ++ +E+ + +E+++
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116
Query: 68 QQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTK 127
QQ+++Q + + K RR++ EE+E+ + EE+++ +P ++ +
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQ-----------EEEQLLREEPEKRRRQE 1165
Query: 128 GGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKA 187
++ Q EEEE ++ + + E+ K E ++ + ++ + +K K +
Sbjct: 1166 --------LERQYREEEELQQEEEQLLREEQ---EKRRQERERQYREEEELQRQKRKQRY 1214
Query: 188 KPQNKFAALDNEEEDKEEEIIKEKEPPKQGKE 219
+ +++ + L + E ++E +++ + +G+E
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246
Score = 44.3 bits (103), Expect = 5e-04
Identities = 43/218 (19%), Positives = 101/218 (46%), Gaps = 32/218 (14%)
Query: 49 DKQAGEEEKVLKEKEQQQQ--QQQQQQKKKRDTRKGRRKKDVDDDGEEKEL--MERLKKL 104
D++ EEE+ L+ +E++++ Q++QQ +++ RK R ++ + + E+++L ER +K+
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI 1749
Query: 105 SVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKA 164
+EE P + + ++ + F Q + E EE++ + K + +
Sbjct: 1750 L----EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ 1805
Query: 165 VSEEQQPALKGKKGK-----------------EEKSKGKAKPQNKFAALDNEEEDKEEEI 207
EEQQ + + GK ++ + + + +FA + +++E
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELW 1865
Query: 208 IKEKEPPKQGKEKAKKAEQM-------EYERQVASLKA 238
+E++ +Q +E+ + E + + RQV +K+
Sbjct: 1866 QEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903
Score = 43.5 bits (101), Expect = 8e-04
Identities = 38/217 (17%), Positives = 108/217 (49%), Gaps = 13/217 (5%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
++ +++ ++D+K ++ E K EEE+ L +++Q++ Q++Q+ +R R +R
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFL-EEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEE 144
++D D E+E + + ++ + E D + + ++ + F ++D+ +
Sbjct: 1550 RQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKF---MEDEQQLRR 1606
Query: 145 EEEKHPPKPAKPEKNRINKAVSEEQQPAL-----KGKKGKEEKSKGKAKPQNKFAALDNE 199
+E + + + K R ++ + +E++ + +K EE+ + + + + + D +
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRD 1666
Query: 200 EEDKEEEII----KEKEPPKQGKEKAKKAEQMEYERQ 232
+ +EEE + +E++ +Q +++ + E+ + RQ
Sbjct: 1667 RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703
Score = 42.0 bits (97), Expect = 0.002
Identities = 43/236 (18%), Positives = 108/236 (45%), Gaps = 30/236 (12%)
Query: 13 EWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQ--- 69
+W + E+ +KV KG+++++ ++ +ED Q L++++ QQ Q
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQ-------LEDSQ-------LRDRQSQQDLQHLL 1271
Query: 70 -QQQQKKKRDTRKGRRKKD---VDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKK 125
+QQ++ + R+ +++D +++ E+E + K+ + +E+ + + ++
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 126 TKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRI------NKAVSEEQQPALKGKKGK 179
+ F Q E EE+ + + K + + K + EEQ+ + ++ K
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391
Query: 180 EEKSKGKAKPQNKFAALDNEEEDK---EEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
K + + + Q + L + + K EE+ + +E ++ +E+ ++ + E ER+
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/228 (16%), Positives = 106/228 (46%), Gaps = 21/228 (9%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
++ V++ ++++K + + ++ EEE++L+E+E+QQ +Q++ +K + + R
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSD-------------EEDEVPAPKPRGGKKTKGGNV 131
+++ D E+EL + + + +E++ + RG ++ + +
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD- 1554
Query: 132 FAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQ- 190
+++ +E EE+ + + K R+ + Q+ K + +++ + + + Q
Sbjct: 1555 -RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQL 1613
Query: 191 -----NKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQV 233
KF + +++EE+ + +E ++ E+ + + E E+Q+
Sbjct: 1614 RQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/144 (22%), Positives = 73/144 (50%), Gaps = 11/144 (7%)
Query: 54 EEEKVLKEKEQQQQQQQQQQKKKRDT-RKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112
E ++ +E+EQ +Q++++QQ + +++ RK R ++ + + EE++L + + +E+
Sbjct: 1768 ERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQ 1827
Query: 113 DEVPAPKPR----GGKKTKGGNVFAALIQDQSEE-----EEEEEKHPPKPAKPEKNRINK 163
++ + R ++ + FA + + EE EEE+++ + K + I +
Sbjct: 1828 LQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR 1887
Query: 164 AVSEEQQPALKGK-KGKEEKSKGK 186
EEQ+ G+ K +E K G+
Sbjct: 1888 QQKEEQRHRQVGEIKSQEGKGHGR 1911
Score = 40.8 bits (94), Expect = 0.005
Identities = 43/198 (21%), Positives = 92/198 (46%), Gaps = 34/198 (17%)
Query: 54 EEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEED 113
+EE+ L+ +E++QQ +Q + +K R+ + +++ D E+E R ++ +EE
Sbjct: 1394 KEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ 1453
Query: 114 EVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPAL 173
++ + R ++ + +E EE++ H + R K + EEQQ
Sbjct: 1454 QLRQERHRKFREE----------EQLLQEREEQQLH-------RQERDRKFLEEEQQLRR 1496
Query: 174 KGKKGK-EEKSKGKAKPQNKFAALDNEEE----------DKEEEIIKEKEPPKQGKE--- 219
+ + K E+ +P+ KF L+ E++ +EE+ ++ +E +Q ++
Sbjct: 1497 QERDRKFREQELRSQEPERKF--LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Query: 220 -KAKKAEQMEYERQVASL 236
K ++ EQ+ ER+ L
Sbjct: 1555 RKFREEEQLRQEREEQQL 1572
Score = 38.5 bits (88), Expect = 0.025
Identities = 41/216 (18%), Positives = 101/216 (46%), Gaps = 32/216 (14%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQ---QQQQQKKKRDTRK 81
++ +++ + ++K ++ E +Q +E+ K E++Q + ++QQ +++ RK
Sbjct: 1713 EQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772
Query: 82 GRRKKDVDDDGEEKELM-----ERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALI 136
R ++ + + EE++L + ++ + E++ P+ R GK
Sbjct: 1773 FREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK--------YRWE 1824
Query: 137 QDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAAL 196
++Q + EE+E++ + E++R +A E+Q A + K +EE+ + + Q +
Sbjct: 1825 EEQLQLEEQEQR-----LRQERDRQYRA---EEQFATQEKSRREEQELWQEEEQKR---- 1872
Query: 197 DNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
+ E ++E+ +Q KE+ + + E + Q
Sbjct: 1873 ----RQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904
Score = 37.7 bits (86), Expect = 0.043
Identities = 37/217 (17%), Positives = 100/217 (46%), Gaps = 24/217 (11%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDD 91
++++++K+ EE + + EE+ +++ +++Q+Q +++ K K + + + + D
Sbjct: 654 RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713
Query: 92 GEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEE-------- 143
+ ++ R +K +E E + R + + A Q Q EE+
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQE--EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771
Query: 144 EEEEK----------HPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKF 193
+ EEK PP + E+ + + +Q L ++ KE++ + + + + +
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 194 AALDNEEE----DKEEEIIKEKEPPKQGKEKAKKAEQ 226
L+ EE+ ++ +++ +E++ ++ +E+ + EQ
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868
Score = 34.7 bits (78), Expect = 0.36
Identities = 18/71 (25%), Positives = 47/71 (66%), Gaps = 2/71 (2%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 562
QQ++++LL++ E ++++ +EL+ + ++ + Q +E L R++Q+ RR+ ++ + +E E
Sbjct: 1147 QQEEEQLLRE-EPEKRRRQELERQYREEEELQ-QEEEQLLREEQEKRRQERERQYREEEE 1204
Query: 563 LLKRPKEYTVR 573
L ++ ++ R
Sbjct: 1205 LQRQKRKQRYR 1215
Score = 33.1 bits (74), Expect = 1.1
Identities = 21/72 (29%), Positives = 42/72 (58%), Gaps = 5/72 (6%)
Query: 504 QKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDE--ESQEAP 561
Q+++E L++ E+QE + + + + +Q + ++ L RKQ++ RR+ Q+E E QE
Sbjct: 272 QEEEEQLRKLERQELRRERQE---EEQQQQRLRREQQLRRKQEEERREQQEERREQQERR 328
Query: 562 ELLKRPKEYTVR 573
E + +E +R
Sbjct: 329 EQQEERREQQLR 340
Score = 32.7 bits (73), Expect = 1.4
Identities = 18/71 (25%), Positives = 45/71 (63%), Gaps = 2/71 (2%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 562
QQ++++LL++ E+++++ +EL+ + ++ + Q +E L R++ + RR+ + E E
Sbjct: 1117 QQEEEQLLRE-EREKRRRQELERQYREEEEVQ-QEEEQLLREEPEKRRRQELERQYREEE 1174
Query: 563 LLKRPKEYTVR 573
L++ +E +R
Sbjct: 1175 ELQQEEEQLLR 1185
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 57.4 bits (137), Expect = 5e-08
Identities = 56/209 (26%), Positives = 93/209 (44%), Gaps = 29/209 (13%)
Query: 592 VTFGYQGQK--PLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEM----R 645
V F Y + P+ + L + + +VG +G GKST++ LL P G++ +
Sbjct: 1040 VVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGK 1099
Query: 646 KNHRLKIGFFNQQYA----EQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTI- 700
+ RL + + E + + + E + G N + + R E++ H
Sbjct: 1100 EIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIV-RAAKEANIHAFI 1158
Query: 701 -------------QICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAI 747
+ +LSGGQK R+ A R+P +L+LDE T+ LD ES + EA+
Sbjct: 1159 ESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEAL 1218
Query: 748 NEYK--GAVIVVSHDARLITETNCQLWVV 774
++ + IV++H RL T N L VV
Sbjct: 1219 DKAREGRTCIVIAH--RLSTIQNADLIVV 1245
Score = 54.7 bits (130), Expect = 3e-07
Identities = 57/233 (24%), Positives = 100/233 (42%), Gaps = 33/233 (14%)
Query: 587 LGLHGVTFGYQGQKP--LFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEM 644
L V F Y +K + K L+ + + +VG +G GKST + L+ PT G +
Sbjct: 392 LEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMV 451
Query: 645 RKNHR----LKIGFFNQQYA----EQLRMEETPTEYLQRGF-NLPYQDARKCLGRFGLES 695
+ + + + F + E + T E ++ G N+ + K + E+
Sbjct: 452 SVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVK----EA 507
Query: 696 HAHTIQI--------------CKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESID 741
+A+ + +LSGGQK R+ A R P +L+LDE T+ LD ES
Sbjct: 508 NAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 567
Query: 742 ALGEAINEYK--GAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKRE 792
+ A+++ + IV++H RL T N + + V G+ ++ +E
Sbjct: 568 VVQVALDKARKGRTTIVIAH--RLSTVRNADVIAGFDDGVIVEKGNHDELMKE 618
Score = 44.7 bits (104), Expect = 4e-04
Identities = 47/187 (25%), Positives = 89/187 (47%), Gaps = 16/187 (8%)
Query: 286 LYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRA 345
L + G+ LVG +G GK+T+++ + P VLL +E+ ++A L
Sbjct: 1058 LEVKKGQTLALVGSSGCGKSTVVQLLER--FYDPLAGKVLLDGKEIKRLNVQWLRAHLGI 1115
Query: 346 DTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLG--FD 403
++ L + + + GD++ E++ AA EA + L +
Sbjct: 1116 VSQEPILFDCS--IAENIAYGDNSRVVSQEEIVR-------AAKEANIHAFIESLPNKYS 1166
Query: 404 PEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWR--K 461
++ ++ TQ SGG + R+++ARAL +P +L+LDE T+ LD + + L R +
Sbjct: 1167 TKVGDKGTQ-LSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGR 1225
Query: 462 TLLIVSH 468
T ++++H
Sbjct: 1226 TCIVIAH 1232
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/69 (36%), Positives = 39/69 (56%), Gaps = 3/69 (4%)
Query: 402 FDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRK 461
FD + R Q SGG + R+++ARAL P +L+LDE T+ LD + + L RK
Sbjct: 520 FDTLVGERGAQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARK 578
Query: 462 --TLLIVSH 468
T ++++H
Sbjct: 579 GRTTIVIAH 587
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 57.4 bits (137), Expect = 5e-08
Identities = 78/392 (19%), Positives = 172/392 (43%), Gaps = 47/392 (11%)
Query: 29 KKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE---------KEQQQQQQQQQQKKKRDT 79
K+ ++++K+ + E+LA E++Q +EE+ L + +E Q + + QK++
Sbjct: 1587 KRAQEERKLAQEE-EKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLA 1645
Query: 80 RKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ-- 137
++G + E ++L ++ KKL+ E +GGK + N+ A ++
Sbjct: 1646 QRGEKLSQ-----EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEEL 1700
Query: 138 -------DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQ 190
D E+E +E + E + + +++E+ ++ KK E+ + A +
Sbjct: 1701 PQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQR 1760
Query: 191 NKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQM--EYERQVASLKAANAAENDFSV 248
K + + + +EE +I+EKE Q KEK + E+ Q+ K A + + +
Sbjct: 1761 EKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWI 1820
Query: 249 -SQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTL 307
S E++ + +L ++ EK +++ ++L + + R + K +
Sbjct: 1821 NSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERL----THSKKQLVQ 1876
Query: 308 LKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGD 367
+K+ I ++ L +++ + V++ K+ KL E E++ L Q +
Sbjct: 1877 VKNKLGMFNKILAQVEEKLTQEK---------ETVIK---KKEKLAETEKK----LVQVE 1920
Query: 368 DTAAERLEKVYEELRATGAAAAEAKARRILAG 399
D+ A++ EK+ +E A + ++ L G
Sbjct: 1921 DSLAKKQEKLAQEKMKLALEKAMVQGKKRLRG 1952
Score = 56.2 bits (134), Expect = 1e-07
Identities = 76/349 (21%), Positives = 153/349 (43%), Gaps = 68/349 (19%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAG-EEEKVLKEKEQQQQQQQQQQKKKRDTRKGR 83
+K K +++ K+ + E + ++++ G EEE+V+ +++ +++++ K+ D K +
Sbjct: 2155 NKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEA--KRGDKPKEK 2212
Query: 84 RKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEE 143
VD+ E+ E ++ L +E S EE
Sbjct: 2213 FSSQVDEVESEEHFSEEMESLLDELEKQES-------------------------LSSEE 2247
Query: 144 EEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDK 203
EEE + E+ R + V EE++ ++E+ +G+ K K EEE K
Sbjct: 2248 EEEREE-------EEEREEEEVREEEEE-------RKEEEEGEEKQVEK-----EEEEKK 2288
Query: 204 EEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENA 263
+++ K+KE ++ +E ++ E++ E + SL E S+ + E+ + +L+
Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEE-EVDREKEILKKE 2347
Query: 264 SDIKL-EKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKT-------TLLKHIANRA 315
KL E+ S G+E L I+ G P+GKG+ + LK + + A
Sbjct: 2348 KQFKLQEQRRKSLRGRERV----LSILRG------VPHGKGRAIRLGVLKSPLKKLMSTA 2397
Query: 316 LSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLE 364
L + V + E+++ ++ A V+ K L +++ER + G+ E
Sbjct: 2398 LEMKEKTPVPVPEKQISWEDKKA--TVVEIPRKFLGTMDKEREVMGKYE 2444
Score = 55.1 bits (131), Expect = 3e-07
Identities = 115/623 (18%), Positives = 251/623 (40%), Gaps = 87/623 (13%)
Query: 7 QQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAV----------EDKQAGEEE 56
Q+ E EW + S + ++GK ++ KK EE A+ E K A EEE
Sbjct: 1716 QELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEE 1775
Query: 57 KVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDD----GEEKEL----MERLKKLSVPT 108
+++EKE+ Q +++ +++ R GR+++ + + +++E ME L K +
Sbjct: 1776 LLIQEKEKLAQHKEKMPEEEE--RLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMIL 1833
Query: 109 SDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRI---NKAV 165
+++ K +K K A ++ +E H K KN++ NK +
Sbjct: 1834 YQKKNLAQEKKNLAQEKEK-----LAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKIL 1888
Query: 166 SEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEK------EPPKQGKE 219
++ ++ + K+ +K + A+ + K +++ K+E++ +EK + QGK+
Sbjct: 1889 AQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKK 1948
Query: 220 KAKKAEQMEYERQVASLKAANAAENDF---------------------SVSQAEMSSRQA 258
+ + + E + +L+ AE ++Q E +
Sbjct: 1949 RLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFER 2008
Query: 259 MLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPN--GKGKTTLLKHIANRAL 316
L I L + I A + L G+R + G K L+K + +
Sbjct: 2009 KLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSK 2068
Query: 317 SIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGD----DTAAE 372
+L Q++ DE Q ++ + L +ERRL + + D D + +
Sbjct: 2069 EPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEK 2128
Query: 373 RLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEP 432
R E +E + A+ +R LA N+ + + +M ++
Sbjct: 2129 RSELTKDEKKL-------ARKQRKLA---------NKMRRMINKEEKMTEEESKLARKHS 2172
Query: 433 TLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQ------GFLDDVCTDIIHLDAQ 486
+++ DE ++ VI + WRK D+ +D+V ++ ++
Sbjct: 2173 EVILDDEEEGGIEEEEVIPF--LKRRWRKRKEAKRGDKPKEKFSSQVDEVESE--EHFSE 2228
Query: 487 RLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQ 546
+ + + ++++E ++ E++E++++E + K ++ E++ E +++
Sbjct: 2229 EMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKK 2288
Query: 547 KCRRKNQDEESQEAPELLKRPKE 569
K +++ + EE QE E+ + +E
Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEKEE 2311
Score = 52.8 bits (125), Expect = 1e-06
Identities = 62/272 (22%), Positives = 115/272 (42%), Gaps = 24/272 (8%)
Query: 18 GESTSPSDKVVKKGKK----------DKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQ 67
GE SP ++++++ KK + + E+ ++++ EE+V +E E+++Q
Sbjct: 1500 GEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
Query: 68 QQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTK 127
Q ++Q+ ++ K R E+K E K +EE + ++ K
Sbjct: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKL----AQEEEKLAQEERQLAQEERK 1615
Query: 128 GGNVFAALIQDQSEEEEEEEKHPPK----PAKPEK--NRINKAVSEEQQPALKGKKGKEE 181
+ + QD E + E K K + EK K + ++ A K +K E
Sbjct: 1616 LAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVARE 1675
Query: 182 KSKGKAKPQNKFAALDNEEEDKEEEI-IKEKEPPKQGKEKAKKAEQMEYERQVASLKAAN 240
+ K AK K A + N K EE+ +E+ Q KE A++ E++E++ + S K
Sbjct: 1676 EEK-LAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEE 1734
Query: 241 AAENDFSVSQAEMSSRQAMLENASDIKLEKFS 272
+ + + E + A E A + EK S
Sbjct: 1735 LNQEEGKL--VEEKKKLAEEEEALAWQREKLS 1764
Score = 50.4 bits (119), Expect = 6e-06
Identities = 77/361 (21%), Positives = 155/361 (42%), Gaps = 39/361 (10%)
Query: 38 KKTFFEELAV-EDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDT----------RKGRRKK 86
K F +E A+ ED G ++V++ KE ++++Q QKK RD +KG++
Sbjct: 1315 KPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVI 1374
Query: 87 DVDDDGEE--KELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEE 144
++ KE+ ++ +K + S ++ K R K K +D SEE E
Sbjct: 1375 FLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIK--REMTKEERDMSEEVE 1432
Query: 145 EEEKHPPKPAKPEKNRINKAVSEEQQPALKG-KKGKEEKSKGKAKPQNKFAALDNEEEDK 203
E K K E K V E+ P+ + KK +E + + + + A +E+
Sbjct: 1433 EMATLEEKVVKQE----GKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAW---KEEW 1485
Query: 204 EEEIIKEKEPPKQGKEKAKKAEQM-EYERQVASLKAANAAENDFSVSQAEMSSRQAMLEN 262
E+ +++E+E Q EK E+M + ++++ + EN S S++ ++
Sbjct: 1486 EKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLS-----SKSKEQQYKD 1540
Query: 263 ASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNI 322
++ LE+ +S G+E + + +R+ + K K
Sbjct: 1541 EEEVTLEE-EVSREGEE----KEQQVTEEQRH--IQEEHKWARIHRKRARAEKKRAQEER 1593
Query: 323 DVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRL---QGQLEQGDDTAAERLEKVYE 379
+ E+++ +E Q + +K+ +++R + +G+ Q ++T A+R EK+ +
Sbjct: 1594 KLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQ 1653
Query: 380 E 380
E
Sbjct: 1654 E 1654
Score = 41.6 bits (96), Expect = 0.003
Identities = 47/222 (21%), Positives = 99/222 (44%), Gaps = 30/222 (13%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
E S D++ K+ + ++ EE E+++ EEE+ KE+E+ +++Q +++++++
Sbjct: 2229 EMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKK 2288
Query: 79 TRKGRRKKDVDDDGEE-----KELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFA 133
+K +KK+ + EE +E+M + S+ +EE+E +
Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEE------------------S 2330
Query: 134 ALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKG---KKGKEEKSKGKAKPQ 190
++++ + E+E K + E+ R + E L+G KG+ + P
Sbjct: 2331 CSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPL 2390
Query: 191 NKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
K + E ++K + P KQ + KKA +E R+
Sbjct: 2391 KKLMSTALEMKEKTPVPV----PEKQISWEDKKATVVEIPRK 2428
Score = 39.3 bits (90), Expect = 0.015
Identities = 45/189 (23%), Positives = 85/189 (44%), Gaps = 13/189 (6%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQ---AGEEEKVLKEK 62
+++ + E G+ + ++ KK KK+KK ++ +E E+K+ + EE + L ++
Sbjct: 2265 EEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDE 2324
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVD-DDGEEKELMERLKKLSVPTSDEEDEVPAPKPR 121
E++++ +++ R+ +++K + K L R + LS+ VP K
Sbjct: 2325 EEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRG-----VPHGK-- 2377
Query: 122 GGKKTKGGNVFAALIQDQSEEEEEEEKHP-PKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
G+ + G + + L + S E +EK P P P K KA E G KE
Sbjct: 2378 -GRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKE 2436
Query: 181 EKSKGKAKP 189
+ GK +P
Sbjct: 2437 REVMGKYEP 2445
Score = 30.0 bits (66), Expect = 8.9
Identities = 21/82 (25%), Positives = 38/82 (46%), Gaps = 5/82 (6%)
Query: 33 KDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGR-----RKKD 87
+DK+ KK ++L + K+ G+E KV+ E+ +Q KK + +G R+
Sbjct: 1176 RDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRST 1235
Query: 88 VDDDGEEKELMERLKKLSVPTS 109
D ++ + RL L + S
Sbjct: 1236 AGDGSSWRDDLCRLMALRISGS 1257
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 57.4 bits (137), Expect = 5e-08
Identities = 44/235 (18%), Positives = 115/235 (48%), Gaps = 28/235 (11%)
Query: 44 ELAVEDKQAGEEEKVLKEKEQQQQQQ------QQQQKKKRDTRKGRRKKDVDDDGEE-KE 96
++ ++ Q GE+E+ + E+E+Q Q+Q Q++Q +K++ + G +++ V E+ ++
Sbjct: 193 QMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQK 252
Query: 97 LMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKP 156
E+++K ++E+++ + + K+ + ++Q+ E+EE+ + + +
Sbjct: 253 QEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ-----EEQTGEQEEQMREQEEQMRE 307
Query: 157 EKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQ------------NKFAALDNEEEDKE 204
++ ++ + EEQ + + GK+E+ + K Q + + + + +E
Sbjct: 308 QEEQMRE--QEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQE 365
Query: 205 EEIIKEKEPPKQGKEKAKKAEQM--EYERQVASLKAANAAENDFSVSQAEMSSRQ 257
E++ K++E ++ +E+ +K E+ + E Q+ K + + Q E Q
Sbjct: 366 EQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQ 420
Score = 55.5 bits (132), Expect = 2e-07
Identities = 39/232 (16%), Positives = 115/232 (49%), Gaps = 18/232 (7%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
M + +Q + E +G+ E + + G+++++++K + E++ +EE++ +
Sbjct: 208 MGEQEEQMQKQEEQMGEQEEQMRKQEE-QMGEQEEQVQKQEEQVQKQEEQMRKQEEQMRE 266
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
++EQ ++Q++Q K+K T + + + ++ E+E E++++ ++E+++ +
Sbjct: 267 QEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE--EQMREQEEQMREQEEQMREQEE 324
Query: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
+ GK+ EE+ E+K K + + + + E+++ K ++
Sbjct: 325 QMGKQ---------------EEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVR 369
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
++ + K + + + + +EE++ ++KE + KE+ ++ E+ E++
Sbjct: 370 KQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQK 421
Score = 52.4 bits (124), Expect = 2e-06
Identities = 35/211 (16%), Positives = 104/211 (49%), Gaps = 9/211 (4%)
Query: 48 EDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVP 107
++ Q E+E ++E+E Q ++Q+ Q +++ + + + + +G+ +E ++++
Sbjct: 127 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 186
Query: 108 TSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSE 167
++E ++ + + G++ + +Q Q E+ E+E+ + + + + E
Sbjct: 187 VREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEE--------QMRKQEEQMGE 238
Query: 168 EQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQM 227
+++ K ++ +++ + K + + + + ++EE+++K+KE +Q ++ ++ EQM
Sbjct: 239 QEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQM 298
Query: 228 -EYERQVASLKAANAAENDFSVSQAEMSSRQ 257
E E Q+ + + + Q E +Q
Sbjct: 299 REQEEQMREQEEQMREQEEQMREQEEQMGKQ 329
Score = 50.4 bits (119), Expect = 6e-06
Identities = 34/189 (17%), Positives = 98/189 (51%), Gaps = 17/189 (8%)
Query: 48 EDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELM----ERLKK 103
++ Q E+E ++E+E Q ++Q+ Q ++ ++G+ + GE++E M E+++K
Sbjct: 162 QEGQVREQEGQVREQEGQVREQEGQVRE----QEGQMGEQEGQMGEQEEQMGEQEEQMQK 217
Query: 104 LSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINK 163
++E+++ + + G++ + Q Q +EE+ +++ + E+ R +
Sbjct: 218 QEEQMGEQEEQMRKQEEQMGEQEE---------QVQKQEEQVQKQEEQMRKQEEQMREQE 268
Query: 164 AVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKK 223
EQ+ + +K + E+ + + + + + + ++EE++ +++E ++ +E+ K
Sbjct: 269 EQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGK 328
Query: 224 AEQMEYERQ 232
E+ +E++
Sbjct: 329 QEEQMWEQK 337
Score = 48.1 bits (113), Expect = 3e-05
Identities = 36/210 (17%), Positives = 99/210 (47%), Gaps = 8/210 (3%)
Query: 48 EDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVP 107
++ Q E+E ++E+E Q ++Q+ Q +++ + + + + +G+ +E ++++
Sbjct: 99 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 158
Query: 108 TSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSE 167
++E +V + G + + G V + + + E+E + + + + E
Sbjct: 159 VREQEGQVR--EQEGQVREQEGQVR----EQEGQVREQEGQMGEQEGQMGEQEEQMGEQE 212
Query: 168 EQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQM 227
EQ + + G++E+ K + Q + + + +EE++ K++E ++ +E+ ++ E+
Sbjct: 213 EQMQKQEEQMGEQEEQMRKQEEQ--MGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQ 270
Query: 228 EYERQVASLKAANAAENDFSVSQAEMSSRQ 257
E++ LK E + + E R+
Sbjct: 271 MREQEEQMLKQKEQTEQEEQTGEQEEQMRE 300
Score = 44.3 bits (103), Expect = 5e-04
Identities = 38/211 (18%), Positives = 104/211 (49%), Gaps = 5/211 (2%)
Query: 26 KVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRK 85
K +K+ + KI ++ ++ Q E+E ++E+E Q ++Q+ Q +++ + +
Sbjct: 35 KELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 94
Query: 86 KDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEE 145
+ + +G+ +E ++++ ++E +V + G + + G V Q + +E +
Sbjct: 95 QVREQEGQVREQEGQVREQEGQVREQEGQV--REQEGQVREQEGQVREQEGQVREQEGQV 152
Query: 146 EEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGK-AKPQNKFAALDNEEEDKE 204
E+ + + R + EQ+ ++ ++G+ + +G+ + + + + + ++E
Sbjct: 153 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQE 212
Query: 205 EEIIKEKEPPKQGKEKAKKAEQM--EYERQV 233
E++ K++E + +E+ +K E+ E E QV
Sbjct: 213 EQMQKQEEQMGEQEEQMRKQEEQMGEQEEQV 243
Score = 44.3 bits (103), Expect = 5e-04
Identities = 36/212 (16%), Positives = 100/212 (47%), Gaps = 4/212 (1%)
Query: 48 EDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVP 107
++ Q E+E ++E+E Q ++Q+ Q +++ + + + + +G+ +E ++++
Sbjct: 64 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 123
Query: 108 TSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSE 167
++E +V + G + + G V Q + +E + E+ + + R +
Sbjct: 124 VREQEGQVR--EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 181
Query: 168 EQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPP--KQGKEKAKKAE 225
EQ+ ++ ++G+ + +G+ Q + E+ K+EE + E+E KQ ++ ++ E
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEE 241
Query: 226 QMEYERQVASLKAANAAENDFSVSQAEMSSRQ 257
Q++ + + + + + + + E R+
Sbjct: 242 QVQKQEEQVQKQEEQMRKQEEQMREQEEQMRE 273
Score = 38.1 bits (87), Expect = 0.033
Identities = 28/151 (18%), Positives = 81/151 (53%), Gaps = 9/151 (5%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAG-EEEKVLKEKEQ 64
K+Q + E G+ E + + ++++ ++ E++ +++Q G +EE++ ++KEQ
Sbjct: 282 KEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQE--EQMREQEEQMGKQEEQMWEQKEQ 339
Query: 65 --QQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELM----ERLKKLSVPTSDEEDEVPAP 118
+Q++Q +Q+++ ++ + +K + +++E M E+++K +E+++
Sbjct: 340 MWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQ 399
Query: 119 KPRGGKKTKGGNVFAALIQDQSEEEEEEEKH 149
K + G++ + + +Q E+ ++E+H
Sbjct: 400 KEQMGEQKEQMREQEEQMGEQKEQMRKQEEH 430
Score = 36.2 bits (82), Expect = 0.12
Identities = 36/218 (16%), Positives = 99/218 (45%), Gaps = 9/218 (4%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
EEL ++ + EE ++++ ++ + Q ++ K+K +T K + +G+ +E +++
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLET----DKIPLPQEGQVREQEGQVR 62
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
+ ++E +V + G + + G V Q + +E + E+ + + R
Sbjct: 63 EQEGQVREQEGQV--REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 120
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKE---PPKQGKE 219
+ EQ+ ++ ++G+ + +G+ + Q + ++E ++E+E ++G+
Sbjct: 121 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 180
Query: 220 KAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQ 257
+ ++ + E E Q+ + + + Q E +Q
Sbjct: 181 REQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQ 218
Score = 35.0 bits (79), Expect = 0.28
Identities = 17/67 (25%), Positives = 44/67 (65%), Gaps = 2/67 (2%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQ--QQQQQQQQQKKKRDTRKGRRKKDVD 89
K++++++K + E++ +EE++ ++KEQ +Q++Q ++Q+++ +K + +K +
Sbjct: 370 KQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEE 429
Query: 90 DDGEEKE 96
GE+KE
Sbjct: 430 HMGEQKE 436
Score = 34.3 bits (77), Expect = 0.47
Identities = 20/72 (27%), Positives = 42/72 (58%), Gaps = 6/72 (8%)
Query: 504 QKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRR----KNQDEESQE 559
QKQ+E + + E+Q +K +E G+ +Q +KQ ++ +++Q ++ + Q+E+ +E
Sbjct: 216 QKQEEQMGEQEEQMRKQEEQM--GEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMRE 273
Query: 560 APELLKRPKEYT 571
E + + KE T
Sbjct: 274 QEEQMLKQKEQT 285
Score = 33.1 bits (74), Expect = 1.1
Identities = 19/69 (27%), Positives = 40/69 (57%), Gaps = 2/69 (2%)
Query: 504 QKQKELLKQYEKQEKKLKEL--KAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAP 561
QKQ+E +++ E+Q +K +E K + KQ E+ ++ +QK + + Q+E+ E
Sbjct: 362 QKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQK 421
Query: 562 ELLKRPKEY 570
E +++ +E+
Sbjct: 422 EQMRKQEEH 430
Score = 32.3 bits (72), Expect = 1.8
Identities = 17/67 (25%), Positives = 40/67 (59%), Gaps = 1/67 (1%)
Query: 504 QKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTR-KQQKCRRKNQDEESQEAPE 562
+KQ+E +++ E+Q ++ +E K + E+QT E + ++Q+ + + Q+E+ +E E
Sbjct: 258 RKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEE 317
Query: 563 LLKRPKE 569
++ +E
Sbjct: 318 QMREQEE 324
Score = 31.6 bits (70), Expect = 3.1
Identities = 13/71 (18%), Positives = 42/71 (59%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
++ Q++++++ KQ E+ K+ ++++ + ++ E+Q + + +Q+ + Q+E+ +
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR 299
Query: 559 EAPELLKRPKE 569
E E ++ +E
Sbjct: 300 EQEEQMREQEE 310
Score = 31.2 bits (69), Expect = 4.0
Identities = 17/71 (23%), Positives = 46/71 (64%), Gaps = 7/71 (9%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
++M++QK++ +E++E+ K+ + G+ +Q +KQ ++ RKQ++ + + Q+E+ +
Sbjct: 331 EQMWEQKEQ----MWEQKEQMWKQEEQMGEQEEQMQKQEEQV--RKQEE-QMRKQEEQMR 383
Query: 559 EAPELLKRPKE 569
+ E +++ +E
Sbjct: 384 KQEEQMRKQEE 394
Score = 30.8 bits (68), Expect = 5.2
Identities = 12/71 (16%), Positives = 43/71 (60%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
++ Q++++++ KQ E+ ++ ++++ + + ++QT++ +Q+ + + Q+E+ +
Sbjct: 247 EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR 306
Query: 559 EAPELLKRPKE 569
E E ++ +E
Sbjct: 307 EQEEQMREQEE 317
Score = 30.0 bits (66), Expect = 8.9
Identities = 12/66 (18%), Positives = 40/66 (60%)
Query: 504 QKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPEL 563
++++++ KQ E+ +K+ ++++ + ++ E+Q +E + ++ + Q+E++ E E
Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297
Query: 564 LKRPKE 569
++ +E
Sbjct: 298 MREQEE 303
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 56.6 bits (135), Expect = 9e-08
Identities = 50/224 (22%), Positives = 107/224 (47%), Gaps = 5/224 (2%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGR- 83
D + ++ K + K EE ++K+ E EK +E+E+++++++++++++R+ + R
Sbjct: 275 DLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERE 334
Query: 84 RKKDVDDDGEEKELMERLK-KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQD-QSE 141
R+K+ + + E + +R + K D E + + R + K + +D + E
Sbjct: 335 REKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERE 394
Query: 142 EEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEE 201
E E E+ + + E+ R + E ++ K KK E+ + A + K E+E
Sbjct: 395 REREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKE 454
Query: 202 DKEEEIIK--EKEPPKQGKEKAKKAEQMEYERQVASLKAANAAE 243
+E +K E K+ +E K+AE+ E R+ + +A E
Sbjct: 455 AAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKE 498
Score = 53.9 bits (128), Expect = 6e-07
Identities = 51/221 (23%), Positives = 112/221 (50%), Gaps = 15/221 (6%)
Query: 29 KKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQ--QQKKKRDTRKGRRKK 86
++ +KDKK + EE A E ++ E+ L+EKE Q++ + + ++++ TR+ ++
Sbjct: 423 REREKDKKRDREEDEEDAYERRKL---ERKLREKEAAYQERLKNWEIRERKKTREYEKEA 479
Query: 87 DVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEE 146
+ +++ +E+ + K+L D +D+ R K G+ ++D+ +E E +
Sbjct: 480 EREEE-RRREMAKEAKRLKEFLEDYDDD------RDDPKYYRGSALQKRLRDREKEMEAD 532
Query: 147 EKHPPKPAKPEKNRINKAVSEEQQPALKGKKGK-EEKSKGKAKPQNKFAA-LDNEEEDKE 204
E+ K K E I + + E P + + E++++ + +PQ K + EEE+K+
Sbjct: 533 ERDR-KREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQ 591
Query: 205 EEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAEND 245
E+ K +EP ++ +E +K R ++S + ++A +
Sbjct: 592 EKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGN 632
Score = 47.0 bits (110), Expect = 7e-05
Identities = 49/213 (23%), Positives = 99/213 (46%), Gaps = 38/213 (17%)
Query: 47 VEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKK--- 103
+ D Q GE++ ++K + + Q + + KK+ + R + V +D EE L E K+
Sbjct: 147 LHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEE-ALDEETKRRDQ 205
Query: 104 -----LSVPTSDEEDEVPAPK------PRGGKKTKGGNVF-----AALI-------QDQS 140
+ V + E+ AP PR KK K ++F A LI +D +
Sbjct: 206 MIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDIN 265
Query: 141 EEEEEEEKHPPKPAKPEKNRINKAVSE--EQQPALKGKKGKEEKSKGKAKPQNKFAALDN 198
E EE+K ++ I++ +S+ + L+ +KGK+EK + + + + + +
Sbjct: 266 AIEMEEDK---------RDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERER 316
Query: 199 EEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYER 231
E E + E +E+E ++ +++ ++ + E +R
Sbjct: 317 ERERERREREREREREREREKEKERERERERDR 349
Score = 46.6 bits (109), Expect = 9e-05
Identities = 46/242 (19%), Positives = 106/242 (43%), Gaps = 29/242 (11%)
Query: 17 DGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKK 76
D + SD+ + + +K + E +++ E + +E+E++++++++++++K
Sbjct: 368 DRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREK 427
Query: 77 RDTRKGRRKKDVDDDGEEKEL-----------MERLKKLSV----PTSDEEDEVPAPKPR 121
+K R++D +D E ++L ERLK + T + E E + R
Sbjct: 428 --DKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEER 485
Query: 122 GGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEE 181
+ K ++D ++ ++ + + + K + +++ + K+ EE
Sbjct: 486 RREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEE 545
Query: 182 -----KSKGKAKPQNKFAALDNEEEDKEEEIIK------EKEPPKQGKEKAKKAEQMEYE 230
++G P + ++ E E + + IK E+E KQ KE+ K+ E ME E
Sbjct: 546 IRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEE-KREEPMEEE 604
Query: 231 RQ 232
+
Sbjct: 605 EE 606
Score = 44.3 bits (103), Expect = 5e-04
Identities = 43/231 (18%), Positives = 97/231 (41%), Gaps = 29/231 (12%)
Query: 24 SDKVVKKGKKDKK--IKKTF-------FEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQK 74
SD +K KK+KK I + F + + ED A E E+ ++ ++ + +
Sbjct: 229 SDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTH 288
Query: 75 KKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAA 134
KK + KG+++K+ + +E+ ER ++ + E E + R
Sbjct: 289 KKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERER------------- 335
Query: 135 LIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFA 194
+ + E E E E+ + E++R + + + +++S+ + K +++
Sbjct: 336 --EKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDR-- 391
Query: 195 ALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAEND 245
E ++E E +E+E ++ + + ++ + E ER+ + E D
Sbjct: 392 ---EREREREREREREREREREREREREREREREREREKDKKRDREEDEED 439
Score = 37.0 bits (84), Expect = 0.073
Identities = 47/214 (21%), Positives = 90/214 (42%), Gaps = 29/214 (13%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
+K ++ ++D+K +K EE+ G + + E Q+ +Q+ +++ R+ +
Sbjct: 526 EKEMEADERDRKREKEELEEIRQRLLAEGHPD---PDAELQRMEQEAERR-----RQPQI 577
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEE--DEVPAPKPRGGKKTKGGNVFAALIQDQSEE 142
K++ + + EE+E E+ +K P +EE ++ P KP + +V +A +
Sbjct: 578 KQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSA--SGNATP 635
Query: 143 EEEEEKHPPKPAKPEKNRINKAVSEEQQPAL--------KGKKGKEEKSKGKAKPQ---- 190
++ P P +N ++ EE +P + G+ K K P
Sbjct: 636 NTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVF 695
Query: 191 NKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKA 224
NKF E+ED ++ K K P E K A
Sbjct: 696 NKF-----EDEDSDDVPRKRKLVPLDYGEDDKNA 724
Score = 33.5 bits (75), Expect = 0.81
Identities = 32/109 (29%), Positives = 53/109 (48%), Gaps = 14/109 (12%)
Query: 490 YYRGNYMTFKKMYQQKQKELLKQYEKQEK-KLKELK----AGGKSTKQAEKQ--TKEALT 542
YYRG+ + + ++K+ E ++ K+EK +L+E++ A G AE Q +EA
Sbjct: 512 YYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAER 571
Query: 543 RKQ----QKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVL 587
R+Q Q+ + ++EE QE E + P E P+ P P L
Sbjct: 572 RRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEE---PEQKPCLKPTL 617
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 56.6 bits (135), Expect = 9e-08
Identities = 45/193 (23%), Positives = 95/193 (49%), Gaps = 17/193 (8%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRK--KDVDDDGEEKELMER 100
E L ++KQ E+E+ ++++E++ +Q ++ ++K + + + K + V+ EEK++ E+
Sbjct: 376 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
Query: 101 LKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNR 160
KK T D+E+++ + ++ K EEEE + K K E+N
Sbjct: 436 EKK----TRDQEEKMQEEERIREREKK-----------MREEEETMREQEEKMQKQEENM 480
Query: 161 INKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEK 220
+ E QQ L +K K + + + + K + + D+EE +EK+ +Q K +
Sbjct: 481 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR 540
Query: 221 AKKAEQMEYERQV 233
++ + E E ++
Sbjct: 541 EQEDQMWEQEEKM 553
Score = 54.7 bits (130), Expect = 3e-07
Identities = 49/235 (20%), Positives = 121/235 (51%), Gaps = 23/235 (9%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
+P+ E W + E K+ K+ +K + ++ E+ E K +EEK+ +
Sbjct: 262 LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQ---EGKMREQEEKMWR 318
Query: 61 EKE---QQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA 117
+++ +Q+++ ++Q+K+ R+ ++ R +++ + EEK + E+ +K+ ++E+++
Sbjct: 319 QEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK-MWEQEEKM----REQEEKMWR 373
Query: 118 PKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKK 177
+ R ++ K ++DQ E E+++ + K E+ R + + E+ + + KK
Sbjct: 374 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLRE--KEERMREQEKMWEQVEKMREEKK 431
Query: 178 GKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
+E++ K + D EE+ +EEE I+E+E + +E+ + ++ + ++Q
Sbjct: 432 MQEQEKKTR----------DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 476
Score = 54.7 bits (130), Expect = 3e-07
Identities = 40/203 (19%), Positives = 106/203 (52%), Gaps = 11/203 (5%)
Query: 34 DKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQ----QQQQKKKRDTRKGRRKKDVD 89
D++ K E + +K+ EEE++++E+E++ Q+Q Q+Q++K + + ++++
Sbjct: 580 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639
Query: 90 DDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKH 149
+E+++ E+ +K+ E+ +P K + + K +Q+Q E+ E+EK
Sbjct: 640 MWEQEEKMWEQEEKMW-----EQQRLPEQKEKLWEHEKMQE--QEKMQEQEEKIWEQEKM 692
Query: 150 PPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIK 209
K + EK ++ E++ + +K E+ + + + K + + +++EEE+ +
Sbjct: 693 EKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWE 752
Query: 210 EKEPPKQGKEKAKKAEQMEYERQ 232
++E + +EK + +++ +++
Sbjct: 753 QEEKMWEQEEKMWEQQRLPEQKE 775
Score = 52.8 bits (125), Expect = 1e-06
Identities = 49/233 (21%), Positives = 113/233 (48%), Gaps = 26/233 (11%)
Query: 11 EPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQ 70
+ E I D E +K + + +K ++ + +E+ E+K +E+K+ ++E+ +++ Q
Sbjct: 516 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ---EEKMRDQEQKMWDQEERMEKKTQ 572
Query: 71 QQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGN 130
+Q+KK D + R EE+ + ER KK+ +EE+ + + + ++ +
Sbjct: 573 EQEKKTWDQEEKMR--------EEERMREREKKM----REEEEMMREQEEKMQEQEEKMQ 620
Query: 131 VFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAK-- 188
+ +Q E+ +E+E+ + + + K +++ P K K + EK + + K
Sbjct: 621 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
Query: 189 -------PQNKFAALDNEEEDK--EEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
Q K E+E K ++E ++E+E ++ ++K ++ E+M E++
Sbjct: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Score = 52.0 bits (123), Expect = 2e-06
Identities = 47/222 (21%), Positives = 114/222 (51%), Gaps = 17/222 (7%)
Query: 28 VKKGKKDKKI----KKTFF-EELAVEDKQAGEEEKVLKE-----KEQQQQQQQQQQKKKR 77
V+K +++KK+ KKT EE E+++ E EK ++E +EQ+++ Q+Q++
Sbjct: 423 VEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 482
Query: 78 DTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ 137
K +++ + + E+ E++++ ++E+++ + G++ K Q
Sbjct: 483 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 542
Query: 138 -DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPA--LKGKKGKEEKSKGKAKPQNKFA 194
DQ E+EE+ + + ++ R+ K E+++ + K +EE+ + + K +
Sbjct: 543 EDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 602
Query: 195 ALDNEEEDK----EEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
+ E+E+K EE++ +++E + +EK ++ E+ +E++
Sbjct: 603 EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644
Score = 51.6 bits (122), Expect = 3e-06
Identities = 47/220 (21%), Positives = 102/220 (46%), Gaps = 31/220 (14%)
Query: 7 QQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQ 66
Q+ E W + + +K+ ++ + ++ +K + E E ++ E+E+ + E+E+ +
Sbjct: 634 QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKME 693
Query: 67 QQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKT 126
++ Q+Q+KK D K R EE+ + ER KK+ EE+E+ +
Sbjct: 694 KKTQEQEKKTWDQEKMR---------EEESMREREKKMR-----EEEEMMREQEE----- 734
Query: 127 KGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGK 186
+Q+Q E+ +E+E+ + + + K +++ P K K + E K
Sbjct: 735 --------KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE----K 782
Query: 187 AKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQ 226
+ Q K + + D+EE++ ++E + +EK + E+
Sbjct: 783 MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEE 822
Score = 51.2 bits (121), Expect = 4e-06
Identities = 50/245 (20%), Positives = 118/245 (48%), Gaps = 37/245 (15%)
Query: 9 PPEPEWIGDGESTSPSDKVVKKGKK----DKKIKKTFFEELAVEDKQAGEEEKVLKEKEQ 64
P + E + + E +K+ ++ +K +K KKT +E D++ EE+ ++E+E+
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
Query: 65 QQQQQQQQQKKKRDTRKGRRKKDVDDDGE----EKELMERLKKLSVPTSDEEDEVPAPKP 120
+ +++++ +++ + + + +K + + E E+++ E+ +K+ E+ +P K
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMW-----EQQRLPEQKE 775
Query: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAK----PEKNRINKAVSEEQQPALKGK 176
+ + K +Q+Q + E+EEK + K EK R + Q+ + G+
Sbjct: 776 KLWEHEK--------MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQ 827
Query: 177 K-----------GKEEKSKGKA-KPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKA 224
+ G+EEK G+ K + K + + ++EE++ ++E ++ +EK +
Sbjct: 828 EEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887
Query: 225 EQMEY 229
E+ Y
Sbjct: 888 EEKIY 892
Score = 46.6 bits (109), Expect = 9e-05
Identities = 48/275 (17%), Positives = 124/275 (45%), Gaps = 11/275 (4%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
M + K Q E + E +++ ++ KK ++ ++T E+ E+K +EE + +
Sbjct: 426 MREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQ---EEKMQKQEENMWE 482
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
++E++ QQQ+ ++K++ + + ++ + E++E + +++ E+ K
Sbjct: 483 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM---WGQEKKMWRQEKM 539
Query: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
R + Q+Q ++EE + +K + E++ + +K
Sbjct: 540 REQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMR 599
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAAN 240
E+ + + + K + + +++EE++ +++E ++ +EK + E+ +E++ +
Sbjct: 600 EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQR 659
Query: 241 AAENDFSVSQAE-MSSRQAMLENASDI----KLEK 270
E + + E M ++ M E I K+EK
Sbjct: 660 LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEK 694
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/221 (14%), Positives = 115/221 (52%), Gaps = 14/221 (6%)
Query: 17 DGESTSPSDKVVKKGKKDKKIKKTFFEELAV--EDKQAGEEEKVLKEKEQQQQQQQQQQK 74
+G+ +K+ ++ K+ ++ +K E+ E K+ E+E+ ++E+E++ +Q+++ +
Sbjct: 306 EGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMR 365
Query: 75 KKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAA 134
++ + + ++ + + + +E ++++ ++++ + + R ++ K
Sbjct: 366 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEK 425
Query: 135 LIQDQSEEEEEEEKHPPKPAKPEKNRI---NKAVSEEQQPALKGKKGKEEKSKGKAKPQN 191
+ +++ +E+E++ + E+ RI K + EE++ +E++ K + + +N
Sbjct: 426 MREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETM------REQEEKMQKQEEN 479
Query: 192 KFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQ 232
+ + EE++ +++ + E++ +EK ++ E+ +E++
Sbjct: 480 MW---EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 517
Score = 44.3 bits (103), Expect = 5e-04
Identities = 54/255 (21%), Positives = 123/255 (48%), Gaps = 35/255 (13%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQA--GEEEKVLKEKEQQQQQQQ--QQQKKKRDTR 80
+K+ ++ K ++ +K + +E + D++ G+E+K+ ++++ ++Q+ Q +Q++K RD
Sbjct: 498 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557
Query: 81 KGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQS 140
+ K ++ EK+ E+ KK T D+E+++ + ++ K +
Sbjct: 558 Q---KMWDQEERMEKKTQEQEKK----TWDQEEKMREEERMREREKKM----------RE 600
Query: 141 EEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGK----EEKS-KGKAKPQNKFAA 195
EEE E+ + EK + + EQ+ ++ ++ K EEK + + K +
Sbjct: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL 660
Query: 196 LDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSS 255
+ +E+ E E ++E+E ++ +EK + E+ME + Q K + Q +M
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKK---------TWDQEKMRE 711
Query: 256 RQAMLENASDIKLEK 270
++M E ++ E+
Sbjct: 712 EESMREREKKMREEE 726
Score = 43.1 bits (100), Expect = 0.001
Identities = 43/227 (18%), Positives = 105/227 (46%), Gaps = 28/227 (12%)
Query: 40 TFFEELAVEDKQAGEEEKVLKEKEQ----QQQQQQQQQKKKRDTRKGRRKKDVDDDGEEK 95
T EE+ ++++ E+EK ++++E+ Q+++ ++Q+ K R+ + +++ +EK
Sbjct: 269 TLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEK 328
Query: 96 ELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSE---EEEEEEKHPPK 152
EL E+ K+L E E +Q+Q E E+EE+ + +
Sbjct: 329 ELREQEKELREQKELREQEEQ-------------------MQEQEEKMWEQEEKMREQEE 369
Query: 153 PAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEE--DKEEEIIKE 210
++ R+ + + ++ K + +E + + + K + +E+ ++ E++ +E
Sbjct: 370 KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREE 429
Query: 211 KEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQ 257
K+ +Q K+ + E+M+ E ++ + E + Q E +Q
Sbjct: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 476
Score = 38.1 bits (87), Expect = 0.033
Identities = 38/196 (19%), Positives = 93/196 (47%), Gaps = 21/196 (10%)
Query: 7 QQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQ 66
Q+ + W D E + + ++ KK ++ ++ E+ E+K +EEK+ +++E+
Sbjct: 697 QEQEKKTW--DQEKMREEESMREREKKMREEEEMMREQ---EEKMQEQEEKMQEQEEEMW 751
Query: 67 QQQQ---QQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAP----- 118
+Q++ +Q++K + ++ +K+ + E+ + E++ + D+E+++
Sbjct: 752 EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMR 811
Query: 119 ----KPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALK 174
K RG ++ G Q++ +EE+ + EK + + EQ+ ++
Sbjct: 812 GQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMR 871
Query: 175 GKKGK----EEKSKGK 186
G++ K EEK +G+
Sbjct: 872 GQEEKMREQEEKMRGQ 887
Score = 35.0 bits (79), Expect = 0.28
Identities = 21/103 (20%), Positives = 55/103 (53%), Gaps = 4/103 (3%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKK----DKKIKKTFFEELAVEDKQAGEEEKVLKE 61
K Q E W + + +K+ + +K ++K++ + E+K G+EEK+ +
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 841
Query: 62 KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKL 104
+E+ Q+++ ++K + + R+++ G+E+++ E+ +K+
Sbjct: 842 EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKM 884
Score = 33.9 bits (76), Expect = 0.62
Identities = 18/77 (23%), Positives = 44/77 (57%), Gaps = 6/77 (7%)
Query: 499 KKMYQQKQK------ELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKN 552
+KM++Q+++ ++ +Q EK ++ K L+ K ++ EK+ +E ++Q+ + +
Sbjct: 293 EKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQE 352
Query: 553 QDEESQEAPELLKRPKE 569
Q+E+ E E ++ +E
Sbjct: 353 QEEKMWEQEEKMREQEE 369
Score = 33.5 bits (75), Expect = 0.81
Identities = 31/184 (16%), Positives = 81/184 (44%), Gaps = 3/184 (1%)
Query: 52 AGEEEKVLKE---KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPT 108
AGE ++ L + ++ + ++ K+RD ++ + E K+ L++
Sbjct: 178 AGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA 237
Query: 109 SDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEE 168
E+ E+ +K + +Q + +EE + + +K R +
Sbjct: 238 ESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR 297
Query: 169 QQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQME 228
Q+ L+ ++GK + + K Q K +E ++E+ ++E++ ++ +E+ ++ E+
Sbjct: 298 QEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKM 357
Query: 229 YERQ 232
+E++
Sbjct: 358 WEQE 361
Score = 33.5 bits (75), Expect = 0.81
Identities = 19/84 (22%), Positives = 48/84 (57%), Gaps = 13/84 (15%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQT--------KEALTRKQQKCRR 550
+K+++ ++ + ++ ++QE+K+ E + K T++ EK+T +E++ +++K R
Sbjct: 665 EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE 724
Query: 551 -----KNQDEESQEAPELLKRPKE 569
+ Q+E+ QE E ++ +E
Sbjct: 725 EEEMMREQEEKMQEQEEKMQEQEE 748
Score = 32.0 bits (71), Expect = 2.4
Identities = 18/71 (25%), Positives = 43/71 (60%), Gaps = 5/71 (7%)
Query: 503 QQKQKELLKQYEKQEKKLKE----LKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
+QK ++ ++ +Q+++L+E ++ K +Q EK +E ++Q+K + ++Q+E+ Q
Sbjct: 389 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEK-KTRDQEEKMQ 447
Query: 559 EAPELLKRPKE 569
E + +R K+
Sbjct: 448 EEERIREREKK 458
Score = 31.6 bits (70), Expect = 3.1
Identities = 19/80 (23%), Positives = 46/80 (57%), Gaps = 9/80 (11%)
Query: 499 KKMY-QQKQKELLKQYEKQEKKLKELKAG--------GKSTKQAEKQTKEALTRKQQKCR 549
KKM+ Q+K +E Q +QE+K+++ + K T++ EK+T + + +++ R
Sbjct: 531 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEER 590
Query: 550 RKNQDEESQEAPELLKRPKE 569
+ ++++ +E E+++ +E
Sbjct: 591 MREREKKMREEEEMMREQEE 610
Score = 30.8 bits (68), Expect = 5.2
Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 20/103 (19%)
Query: 484 DAQRLHYYRGNYMTFKKMYQQK----QKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKE 539
+ QRL + +KM +Q+ Q+E + + EK EKK +E + K T EK +E
Sbjct: 656 EQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE---KKTWDQEKMREE 712
Query: 540 ALTRKQQKCRRKN-------------QDEESQEAPELLKRPKE 569
R+++K R+ Q+E+ QE E + +E
Sbjct: 713 ESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 55.8 bits (133), Expect = 2e-07
Identities = 56/258 (21%), Positives = 117/258 (45%), Gaps = 24/258 (9%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
++T+P + + + +K +E + +A EE+ K +E+ ++QQ++ +++++
Sbjct: 709 DTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQE 768
Query: 79 TRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQD 138
+ RR EE+EL R K+ E E+ + R ++ + +++
Sbjct: 769 EERKRR--------EEEELARR-KQEEALRRQREQEIALRRQREEEERQQQEEALRRLEE 819
Query: 139 QSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDN 198
+ EEEE K K E+ A EE+ + + + + + + A L +
Sbjct: 820 RRREEEERRKQEELLRKQEEEAAKWAREEEE--------AQRRLEENRLRMEEEAARLRH 871
Query: 199 EEED---KEEEIIKEKE---PPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAE 252
EEE+ KE E+ ++KE +Q +E ++ +Q + ++Q+A +K +++ S
Sbjct: 872 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG-QQSNTT 930
Query: 253 MSSRQAMLENASDIKLEK 270
QA L A KLE+
Sbjct: 931 ACQSQATLSLAEIQKLEE 948
Score = 38.5 bits (88), Expect = 0.025
Identities = 33/190 (17%), Positives = 92/190 (48%), Gaps = 8/190 (4%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDD 91
K++++ K EE E ++ EE ++ E+E + + +++++K+++ R+K+ +
Sbjct: 836 KQEEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 893
Query: 92 GEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ--DQSEEEEEEEKH 149
+++E + RL++ + ++P+ G + A + + + EEE E+
Sbjct: 894 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ 953
Query: 150 PPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIK 209
+ + ++ + KA+ ++QQ + G S KP +L ++++ ++ K
Sbjct: 954 LREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS----KPSGTTKSLLEIQQEEARQMQK 1009
Query: 210 EKEPPKQGKE 219
+++ +Q ++
Sbjct: 1010 QQQQQQQHQQ 1019
Score = 37.7 bits (86), Expect = 0.043
Identities = 20/70 (28%), Positives = 46/70 (65%), Gaps = 9/70 (12%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQK---CRRKNQDEESQE 559
+++Q+E+L++ +++E+K +E + A ++ +EAL R++++ RR+ ++EE Q+
Sbjct: 756 RRQQEEILRRQQEEERKRRE------EEELARRKQEEALRRQREQEIALRRQREEEERQQ 809
Query: 560 APELLKRPKE 569
E L+R +E
Sbjct: 810 QEEALRRLEE 819
Score = 34.7 bits (78), Expect = 0.36
Identities = 19/76 (25%), Positives = 45/76 (59%), Gaps = 8/76 (10%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
+++ ++KQ+E L++ +QE L+ + ++ E+Q +E R+ ++ RR+ ++ Q
Sbjct: 777 EELARRKQEEALRRQREQEIALR------RQREEEERQQQEEALRRLEERRREEEERRKQ 830
Query: 559 EAPELLKRPKEYTVRF 574
E ELL++ +E ++
Sbjct: 831 E--ELLRKQEEEAAKW 844
Score = 32.3 bits (72), Expect = 1.8
Identities = 18/71 (25%), Positives = 38/71 (53%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
K++ Q+QKEL++Q ++Q++ L+ L+ + + A+ + + T QQ Q + +
Sbjct: 879 KELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 938
Query: 559 EAPELLKRPKE 569
E+ K +E
Sbjct: 939 SLAEIQKLEEE 949
Score = 32.3 bits (72), Expect = 1.8
Identities = 14/69 (20%), Positives = 39/69 (56%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 562
+++Q+EL+K ++Q+++ ++ +G + + TK L +Q++ R+ + ++ Q+ +
Sbjct: 959 RRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQ 1018
Query: 563 LLKRPKEYT 571
R + T
Sbjct: 1019 QPNRARNNT 1027
Score = 32.0 bits (71), Expect = 2.4
Identities = 17/76 (22%), Positives = 43/76 (56%), Gaps = 2/76 (2%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEE-- 556
+++ + K +L ++ + E + K + K ++ +Q +E L R+Q++ R++ ++EE
Sbjct: 721 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 780
Query: 557 SQEAPELLKRPKEYTV 572
++ E L+R +E +
Sbjct: 781 RRKQEEALRRQREQEI 796
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 55.8 bits (133), Expect = 2e-07
Identities = 56/258 (21%), Positives = 117/258 (45%), Gaps = 24/258 (9%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
++T+P + + + +K +E + +A EE+ K +E+ ++QQ++ +++++
Sbjct: 736 DTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQE 795
Query: 79 TRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQD 138
+ RR EE+EL R K+ E E+ + R ++ + +++
Sbjct: 796 EERKRR--------EEEELARR-KQEEALRRQREQEIALRRQREEEERQQQEEALRRLEE 846
Query: 139 QSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDN 198
+ EEEE K K E+ A EE+ + + + + + + A L +
Sbjct: 847 RRREEEERRKQEELLRKQEEEAAKWAREEEE--------AQRRLEENRLRMEEEAARLRH 898
Query: 199 EEED---KEEEIIKEKE---PPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAE 252
EEE+ KE E+ ++KE +Q +E ++ +Q + ++Q+A +K +++ S
Sbjct: 899 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG-QQSNTT 957
Query: 253 MSSRQAMLENASDIKLEK 270
QA L A KLE+
Sbjct: 958 ACQSQATLSLAEIQKLEE 975
Score = 38.5 bits (88), Expect = 0.025
Identities = 33/190 (17%), Positives = 92/190 (48%), Gaps = 8/190 (4%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDD 91
K++++ K EE E ++ EE ++ E+E + + +++++K+++ R+K+ +
Sbjct: 863 KQEEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 920
Query: 92 GEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ--DQSEEEEEEEKH 149
+++E + RL++ + ++P+ G + A + + + EEE E+
Sbjct: 921 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ 980
Query: 150 PPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIK 209
+ + ++ + KA+ ++QQ + G S KP +L ++++ ++ K
Sbjct: 981 LREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS----KPSGTTKSLLEIQQEEARQMQK 1036
Query: 210 EKEPPKQGKE 219
+++ +Q ++
Sbjct: 1037 QQQQQQQHQQ 1046
Score = 37.7 bits (86), Expect = 0.043
Identities = 20/70 (28%), Positives = 46/70 (65%), Gaps = 9/70 (12%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQK---CRRKNQDEESQE 559
+++Q+E+L++ +++E+K +E + A ++ +EAL R++++ RR+ ++EE Q+
Sbjct: 783 RRQQEEILRRQQEEERKRRE------EEELARRKQEEALRRQREQEIALRRQREEEERQQ 836
Query: 560 APELLKRPKE 569
E L+R +E
Sbjct: 837 QEEALRRLEE 846
Score = 34.7 bits (78), Expect = 0.36
Identities = 19/76 (25%), Positives = 45/76 (59%), Gaps = 8/76 (10%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
+++ ++KQ+E L++ +QE L+ + ++ E+Q +E R+ ++ RR+ ++ Q
Sbjct: 804 EELARRKQEEALRRQREQEIALR------RQREEEERQQQEEALRRLEERRREEEERRKQ 857
Query: 559 EAPELLKRPKEYTVRF 574
E ELL++ +E ++
Sbjct: 858 E--ELLRKQEEEAAKW 871
Score = 32.3 bits (72), Expect = 1.8
Identities = 18/71 (25%), Positives = 38/71 (53%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
K++ Q+QKEL++Q ++Q++ L+ L+ + + A+ + + T QQ Q + +
Sbjct: 906 KELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 965
Query: 559 EAPELLKRPKE 569
E+ K +E
Sbjct: 966 SLAEIQKLEEE 976
Score = 32.3 bits (72), Expect = 1.8
Identities = 14/69 (20%), Positives = 39/69 (56%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 562
+++Q+EL+K ++Q+++ ++ +G + + TK L +Q++ R+ + ++ Q+ +
Sbjct: 986 RRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQ 1045
Query: 563 LLKRPKEYT 571
R + T
Sbjct: 1046 QPNRARNNT 1054
Score = 32.0 bits (71), Expect = 2.4
Identities = 17/76 (22%), Positives = 43/76 (56%), Gaps = 2/76 (2%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEE-- 556
+++ + K +L ++ + E + K + K ++ +Q +E L R+Q++ R++ ++EE
Sbjct: 748 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 807
Query: 557 SQEAPELLKRPKEYTV 572
++ E L+R +E +
Sbjct: 808 RRKQEEALRRQREQEI 823
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 55.8 bits (133), Expect = 2e-07
Identities = 56/258 (21%), Positives = 117/258 (45%), Gaps = 24/258 (9%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
++T+P + + + +K +E + +A EE+ K +E+ ++QQ++ +++++
Sbjct: 715 DTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQE 774
Query: 79 TRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQD 138
+ RR EE+EL R K+ E E+ + R ++ + +++
Sbjct: 775 EERKRR--------EEEELARR-KQEEALRRQREQEIALRRQREEEERQQQEEALRRLEE 825
Query: 139 QSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDN 198
+ EEEE K K E+ A EE+ + + + + + + A L +
Sbjct: 826 RRREEEERRKQEELLRKQEEEAAKWAREEEE--------AQRRLEENRLRMEEEAARLRH 877
Query: 199 EEED---KEEEIIKEKE---PPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAE 252
EEE+ KE E+ ++KE +Q +E ++ +Q + ++Q+A +K +++ S
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG-QQSNTT 936
Query: 253 MSSRQAMLENASDIKLEK 270
QA L A KLE+
Sbjct: 937 ACQSQATLSLAEIQKLEE 954
Score = 38.5 bits (88), Expect = 0.025
Identities = 33/190 (17%), Positives = 92/190 (48%), Gaps = 8/190 (4%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDD 91
K++++ K EE E ++ EE ++ E+E + + +++++K+++ R+K+ +
Sbjct: 842 KQEEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 899
Query: 92 GEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ--DQSEEEEEEEKH 149
+++E + RL++ + ++P+ G + A + + + EEE E+
Sbjct: 900 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ 959
Query: 150 PPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIK 209
+ + ++ + KA+ ++QQ + G S KP +L ++++ ++ K
Sbjct: 960 LREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS----KPSGTTKSLLEIQQEEARQMQK 1015
Query: 210 EKEPPKQGKE 219
+++ +Q ++
Sbjct: 1016 QQQQQQQHQQ 1025
Score = 37.7 bits (86), Expect = 0.043
Identities = 20/70 (28%), Positives = 46/70 (65%), Gaps = 9/70 (12%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQK---CRRKNQDEESQE 559
+++Q+E+L++ +++E+K +E + A ++ +EAL R++++ RR+ ++EE Q+
Sbjct: 762 RRQQEEILRRQQEEERKRRE------EEELARRKQEEALRRQREQEIALRRQREEEERQQ 815
Query: 560 APELLKRPKE 569
E L+R +E
Sbjct: 816 QEEALRRLEE 825
Score = 34.7 bits (78), Expect = 0.36
Identities = 19/76 (25%), Positives = 45/76 (59%), Gaps = 8/76 (10%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
+++ ++KQ+E L++ +QE L+ + ++ E+Q +E R+ ++ RR+ ++ Q
Sbjct: 783 EELARRKQEEALRRQREQEIALR------RQREEEERQQQEEALRRLEERRREEEERRKQ 836
Query: 559 EAPELLKRPKEYTVRF 574
E ELL++ +E ++
Sbjct: 837 E--ELLRKQEEEAAKW 850
Score = 32.3 bits (72), Expect = 1.8
Identities = 18/71 (25%), Positives = 38/71 (53%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 558
K++ Q+QKEL++Q ++Q++ L+ L+ + + A+ + + T QQ Q + +
Sbjct: 885 KELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATL 944
Query: 559 EAPELLKRPKE 569
E+ K +E
Sbjct: 945 SLAEIQKLEEE 955
Score = 32.3 bits (72), Expect = 1.8
Identities = 14/69 (20%), Positives = 39/69 (56%)
Query: 503 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 562
+++Q+EL+K ++Q+++ ++ +G + + TK L +Q++ R+ + ++ Q+ +
Sbjct: 965 RRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQ 1024
Query: 563 LLKRPKEYT 571
R + T
Sbjct: 1025 QPNRARNNT 1033
Score = 32.0 bits (71), Expect = 2.4
Identities = 17/76 (22%), Positives = 43/76 (56%), Gaps = 2/76 (2%)
Query: 499 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEE-- 556
+++ + K +L ++ + E + K + K ++ +Q +E L R+Q++ R++ ++EE
Sbjct: 727 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 786
Query: 557 SQEAPELLKRPKEYTV 572
++ E L+R +E +
Sbjct: 787 RRKQEEALRRQREQEI 802
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.131 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,853,852
Number of Sequences: 37866
Number of extensions: 1805336
Number of successful extensions: 38409
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 602
Number of HSP's successfully gapped in prelim test: 1156
Number of HSP's that attempted gapping in prelim test: 13709
Number of HSP's gapped (non-prelim): 12977
length of query: 807
length of database: 18,247,518
effective HSP length: 110
effective length of query: 697
effective length of database: 14,082,258
effective search space: 9815333826
effective search space used: 9815333826
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.