Search of human proteins with 9910266

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|9910266 kinesin family member 15 [Homo sapiens]
         (1388 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|9910266 kinesin family member 15 [Homo sapiens]                   2684   0.0  
gi|71061468 centromere protein E [Homo sapiens]                       348   2e-95
gi|116686122 kinesin family member 4 [Homo sapiens]                   315   1e-85
gi|150010604 kinesin family member 4B [Homo sapiens]                  304   3e-82
gi|46852174 kinesin family member 3A [Homo sapiens]                   301   3e-81
gi|4758646 kinesin family member 3B [Homo sapiens]                    300   6e-81
gi|170784809 kinesin family member 17 isoform b [Homo sapiens]        291   4e-78
gi|170784807 kinesin family member 17 isoform a [Homo sapiens]        291   4e-78
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]        285   2e-76
gi|41352705 kinesin family member 3C [Homo sapiens]                   284   4e-76
gi|4758650 kinesin family member 5C [Homo sapiens]                    274   5e-73
gi|83716024 kinesin family member 21B [Homo sapiens]                  271   2e-72
gi|45446749 kinesin family member 5A [Homo sapiens]                   268   3e-71
gi|30794488 kinesin family member 27 [Homo sapiens]                   266   1e-70
gi|38569484 kinesin family member 21A [Homo sapiens]                  263   1e-69
gi|4758648 kinesin family member 5B [Homo sapiens]                    262   2e-69
gi|13699824 kinesin family member 11 [Homo sapiens]                   261   4e-69
gi|157738629 kinesin family member 13A isoform d [Homo sapiens]       256   8e-68
gi|157738627 kinesin family member 13A isoform c [Homo sapiens]       256   8e-68
gi|157738625 kinesin family member 13A isoform b [Homo sapiens]       256   8e-68
gi|157738621 kinesin family member 13A isoform a [Homo sapiens]       256   8e-68
gi|46852172 kinesin family member 13B [Homo sapiens]                  256   8e-68
gi|41393563 kinesin family member 1B isoform b [Homo sapiens]         254   5e-67
gi|19924175 axonal transport of synaptic vesicles [Homo sapiens]      253   1e-66
gi|41393559 kinesin family member 1B isoform alpha [Homo sapiens]     245   2e-64
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]                   244   3e-64
gi|40254834 kinesin family member 1C [Homo sapiens]                   241   4e-63
gi|157502184 kinesin family member 6 [Homo sapiens]                   232   2e-60
gi|7661878 kinesin family member 14 [Homo sapiens]                    228   4e-59
gi|199560800 kinesin family member 9 isoform 2 [Homo sapiens]         224   4e-58

>gi|9910266 kinesin family member 15 [Homo sapiens]
          Length = 1388

 Score = 2684 bits (6958), Expect = 0.0
 Identities = 1388/1388 (100%), Positives = 1388/1388 (100%)

Query: 1    MAPGCKTELRSVTNGQSNQPSNEGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLR 60
            MAPGCKTELRSVTNGQSNQPSNEGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLR
Sbjct: 1    MAPGCKTELRSVTNGQSNQPSNEGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLR 60

Query: 61   LHSNPEPKTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMM 120
            LHSNPEPKTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMM
Sbjct: 61   LHSNPEPKTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMM 120

Query: 121  GPSESDNFSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDS 180
            GPSESDNFSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDS
Sbjct: 121  GPSESDNFSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDS 180

Query: 181  ASAGLYLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVF 240
            ASAGLYLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVF
Sbjct: 181  ASAGLYLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVF 240

Query: 241  TITIESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVIT 300
            TITIESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVIT
Sbjct: 241  TITIESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVIT 300

Query: 301  ALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRA 360
            ALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRA
Sbjct: 301  ALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRA 360

Query: 361  KLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQE 420
            KLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQE
Sbjct: 361  KLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQE 420

Query: 421  AMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGG 480
            AMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGG
Sbjct: 421  AMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGG 480

Query: 481  FLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMD 540
            FLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMD
Sbjct: 481  FLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMD 540

Query: 541  AQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQ 600
            AQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQ
Sbjct: 541  AQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQ 600

Query: 601  EYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIIT 660
            EYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIIT
Sbjct: 601  EYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIIT 660

Query: 661  TPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELR 720
            TPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELR
Sbjct: 661  TPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELR 720

Query: 721  TVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLN 780
            TVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLN
Sbjct: 721  TVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLN 780

Query: 781  VLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHM 840
            VLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHM
Sbjct: 781  VLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHM 840

Query: 841  HVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLN 900
            HVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLN
Sbjct: 841  HVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLN 900

Query: 901  NLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLE 960
            NLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLE
Sbjct: 901  NLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLE 960

Query: 961  ESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYN 1020
            ESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYN
Sbjct: 961  ESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYN 1020

Query: 1021 SALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASK 1080
            SALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASK
Sbjct: 1021 SALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASK 1080

Query: 1081 KHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQ 1140
            KHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQ
Sbjct: 1081 KHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQ 1140

Query: 1141 SPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLRE 1200
            SPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLRE
Sbjct: 1141 SPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLRE 1200

Query: 1201 MENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIV 1260
            MENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIV
Sbjct: 1201 MENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIV 1260

Query: 1261 EEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERE 1320
            EEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERE
Sbjct: 1261 EEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERE 1320

Query: 1321 RTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFL 1380
            RTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFL
Sbjct: 1321 RTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFL 1380

Query: 1381 KEKKRSES 1388
            KEKKRSES
Sbjct: 1381 KEKKRSES 1388


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  348 bits (893), Expect = 2e-95
 Identities = 386/1482 (26%), Positives = 659/1482 (44%), Gaps = 210/1482 (14%)

Query: 23   EGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPEPKTFTFDHVADVDTTQ 82
            E  A+ V VR+RP   R  S      +     ++   ++  +   K+F FD V   + T 
Sbjct: 3    EEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGS---KSFNFDRVFHGNETT 59

Query: 83   ESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEY 142
            ++V+  +A  I++S + GYNGTIFAYGQT SGKT+TMMG       S +  GVIPR+   
Sbjct: 60   KNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMG-------SEDHLGVIPRAIHD 112

Query: 143  LFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLL--DSASAGLYLREHIKKGVFVVGA 200
            +F     +K K    + FL + S++EIYNE I DLL        L +RE + + V+V   
Sbjct: 113  IF-----QKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADL 167

Query: 201  VEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEK---SNEIVNIR 257
             E+VV ++  A + ++ G ++R    T MN+ SSRSH +F + +ES EK   SN   +++
Sbjct: 168  TEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVK 227

Query: 258  TSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRD 317
             S LNLVDLAGSER   T A G+RLKE  NINRSL  LGQVI  L D   G    + YRD
Sbjct: 228  VSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVG--GFINYRD 285

Query: 318  SKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNV 377
            SKLT +L++SLGGNAKT II  + P S  F ETL+ L FA  AK +KN   VNE     V
Sbjct: 286  SKLTRILQNSLGGNAKTRIICTITPVS--FDETLTALQFASTAKYMKNTPYVNE-----V 338

Query: 378  SQLQAEVKRLKEQLAELASGQTPPESFLTRDK--KKTNYMEYFQEAMLFFKKSEQEKKSL 435
            S  +A +KR ++++ +L   Q    S  TR +  +K    +  +E  L  K   ++ ++L
Sbjct: 339  STDEALLKRYRKEIMDLKK-QLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENL 397

Query: 436  IEKVTQLEDLTLKKEKFIQS-----------NKMIVKFREDQI----IRLEKLHKESRGG 480
               +     LTL++E   +            NKM      DQ         K HK S   
Sbjct: 398  TRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSI-N 456

Query: 481  FLPEEQDRLLSE---LRNEIQTLREQIEHHPRVAKYAMEN-----HSLREENRRLRLLEP 532
             L E  + + SE     N + TL E IE +P       EN     +SLR +   L L   
Sbjct: 457  LLREIDESVCSESDVFSNTLDTLSE-IEWNPATKLLNQENIESELNSLRADYDNLVLDYE 515

Query: 533  VKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQ 592
              R ++ + +   K +    E   +E+  K  Q        E  L      LK  +   +
Sbjct: 516  QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ--------EMQLIHEISNLKNLVKHAE 567

Query: 593  TELNNSKQEYEEFKELTRKRQLELES-----ELQSLQKANLNLENLLEATKACKRQEVSQ 647
                + + E     EL R+++ +++      + Q L+   ++L   LE+ +  K+ + + 
Sbjct: 568  VYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTL 627

Query: 648  LNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEM 707
             +   AET+ +      A+ L S  + +L  +M    + Y Q    ++NDI       E 
Sbjct: 628  FD---AETVALDAKRESAF-LRSENL-ELKEKMKELATTYKQ----MENDIQLYQSQLEA 678

Query: 708  NEQAFEAISEELRTVQEQMSALQAKLD-----------EEEHKNLKLQQHVDK--LEHHS 754
             ++    + +EL++   +++ L + +D           E E K   LQ+ ++K   E+ +
Sbjct: 679  KKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEA 738

Query: 755  TQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKEL 814
             + + +  SE      + E L  ++    ++L    ++ D L SEV      +    +E+
Sbjct: 739  LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798

Query: 815  SSVKLEYSSFKTN---QEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQ 871
               K + ++ ++N    ++EF      HM  + +   +  ENE+                
Sbjct: 799  GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENER---------------- 842

Query: 872  EIMKFEIDQLSRNLQNFKKENETLKSDLN----NLMELLEAEKERNNKLSLQFEEDKENS 927
              M  EI  LS+  Q F      LK++L+     L E     +ER N++  Q +E  EN 
Sbjct: 843  --MNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEME-QLKEQLENR 899

Query: 928  SKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADL 987
                   L+ V +EK   T K +Q + +V+ L +     +++  SL+  RD  K  + D 
Sbjct: 900  D----STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDT 955

Query: 988  MN-------QIQELRTSVCEKTETIDTLKQEL---------------------------- 1012
            +N       Q++    S+ +  ETI+TLK ++                            
Sbjct: 956  VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI 1015

Query: 1013 ---KDINCKYNSALVDREESRVLIKKQE--VDILDLKETLRLRILSEDIERDMLCEDL-- 1065
               +D+  K    L    +   +I++Q     ++  K  L+  + S   E++ L  DL  
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075

Query: 1066 -----AHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNE 1120
                     E+L +L +  KK   ++   +    KKE  +     +L + +E++++K  +
Sbjct: 1076 NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ 1135

Query: 1121 YNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKL 1180
               K +QL +V +  +E              + K +   E    + +  + +LEH+ T+ 
Sbjct: 1136 LQEKQQQLLNVQEEMSE--------------MQKKINEIENLKNELKNKELTLEHMETER 1181

Query: 1181 NEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIK----RQKENSDQNH 1236
             E  +  N     +K   +E + L+   +    +   L+G + +I+    + KE     H
Sbjct: 1182 LELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAH 1241

Query: 1237 ---PDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVER 1293
                ++Q+  +E   S+ E+ A+    +++ K    L+E +  + ++E E L    EV  
Sbjct: 1242 IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE-EIPVLHEEQELLPNVKEVSE 1300

Query: 1294 TQTLESKAFQEKEQLRSK----LEEMYEERERTSQEMEMLRKQVECLAEENGKL------ 1343
            TQ   ++     EQ  +K    L  +  ER R +++ +  +++++ L +E   L      
Sbjct: 1301 TQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEA 1360

Query: 1344 --VGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFLKEK 1383
              V H  L + I       +E +   +E++  + +++ +KEK
Sbjct: 1361 LEVKHDQLKEHI-------RETLAKIQESQSKQEQSLNMKEK 1395



 Score =  142 bits (358), Expect = 2e-33
 Identities = 257/1140 (22%), Positives = 482/1140 (42%), Gaps = 191/1140 (16%)

Query: 372  DTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKS--- 428
            D +   + L++E   LKE++ ELA          T  K+  N ++ +Q  +   KK    
Sbjct: 636  DAKRESAFLRSENLELKEKMKELA----------TTYKQMENDIQLYQSQLEAKKKMQVD 685

Query: 429  -EQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEK-LHKESRGGFLPEEQ 486
             E+E +S   ++T+L  L   K   +  + +     E +I  L+K L+KE        E+
Sbjct: 686  LEKELQSAFNEITKLTSLIDGK---VPKDLLCNLELEGKITDLQKELNKEVEENEALREE 742

Query: 487  DRLLSELRN---EIQTLREQIE------HHPRVAKYAMENHSLREENRRLRLLEPVKRAQ 537
              LLSEL++   E++ LR++I+      H     K  + +  + +E+R   LLE + + +
Sbjct: 743  VILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK 802

Query: 538  EMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNN 597
            +  A T +  +    E    +    + +      QK   +    E++  +++       N
Sbjct: 803  DDLATTQSNYKSTDQEFQNFKTLHMDFE------QKYKMVLEENERMNQEIV-------N 849

Query: 598  SKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQ---EVSQLNKIHAE 654
              +E ++F       + EL  + Q LQ+    ++  L   +  K Q     S L  +  E
Sbjct: 850  LSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVERE 909

Query: 655  TLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMN------ 708
               I    T+  Q     V  L+ E      L  Q S  ++ D L   +   +N      
Sbjct: 910  KTLI----TEKLQQTLEEVKTLTQEKDDLKQL--QESLQIERDQLKSDIHDTVNMNIDTQ 963

Query: 709  EQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQH--------------VDK---LE 751
            EQ   A+ E L+  QE ++ L++K+ EE  +NL ++++              +DK   LE
Sbjct: 964  EQLRNAL-ESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLE 1022

Query: 752  HHSTQM--QELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHS 809
              +TQ    ++  +E I+  ++   L+ + N L++ L+    + + LK+   DL+  +  
Sbjct: 1023 AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKT---DLKENIEM 1079

Query: 810  ADKELSSVKLEYSSFKTNQE---KEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDS 866
              +    ++L     K  QE   +E N   ++   +    D L    EKL E    LQ+ 
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139

Query: 867  YDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNN---LMELLEAEK-ERNNKLSLQFEE 922
               L  + + E+ ++ + +     E E LK++L N    +E +E E+ E   KL+  +EE
Sbjct: 1140 QQQLLNVQE-EMSEMQKKIN----EIENLKNELKNKELTLEHMETERLELAQKLNENYEE 1194

Query: 923  DKE-NSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDK 981
             K     +++LK L+     K  ET + +     ++++E + L T++ +          +
Sbjct: 1195 VKSITKERKVLKELQ-----KSFETER-DHLRGYIREIEATGLQTKEELKIAHIHLKEHQ 1248

Query: 982  KVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSAL-VDREESRVLIKKQEVDI 1040
            +        I ELR SV EKT  I    Q+L+  + K    + V  EE  +L   +EV  
Sbjct: 1249 ET-------IDELRRSVSEKTAQIINT-QDLEKSHTKLQEEIPVLHEEQELLPNVKEVS- 1299

Query: 1041 LDLKETLR-LRILSE-------------DIERDMLCEDLAHATEQLNMLTEASK------ 1080
             + +ET+  L +L+E             ++ER  L E    + E++  LT+         
Sbjct: 1300 -ETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIK 1358

Query: 1081 -----KHSGLLQSAQEELTKKEALIQELQHKLNQKKE---------EVEQKKNE------ 1120
                 KH  L +  +E L K +    + +  LN K++         E+EQ K +      
Sbjct: 1359 EALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR 1418

Query: 1121 -------YNFKMRQLEHVMDSAAEDP------------QSPKTPPHFQTHLAKLLETQEQ 1161
                    + ++++    M S A++             +S +   + +  +AK LET+E 
Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEE- 1477

Query: 1162 EIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREM-ENLRLESQQLIEKNWL--- 1217
            E++         E  + +L  +   K  EI  +++QL  + + L+ + Q++ EK      
Sbjct: 1478 ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNI 1537

Query: 1218 -----LQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEE 1272
                 +Q +++++K+ KE+        Q ++++  E         + ++ M+K K +++ 
Sbjct: 1538 KQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR 1597

Query: 1273 VQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQ 1332
            VQ AL  +  +    T E+      + K  QEKE    K+  + E +E+   E+E L++Q
Sbjct: 1598 VQEALQIERDQLKENTKEI----VAKMKESQEKEYQFLKMTAVNETQEKMC-EIEHLKEQ 1652

Query: 1333 VEC-------LAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFLKEKKR 1385
             E        +  EN +L   Q LH+ ++ +  + KE   L    E L+ E   LKE  R
Sbjct: 1653 FETQKLNLENIETENIRLT--QILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLR 1710



 Score =  140 bits (354), Expect = 6e-33
 Identities = 244/1160 (21%), Positives = 492/1160 (42%), Gaps = 207/1160 (17%)

Query: 245  ESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVD 304
            E  +K NEI N++  L N       +     H E  RL+ A  +N +   +  +      
Sbjct: 1152 EMQKKINEIENLKNELKN-------KELTLEHMETERLELAQKLNENYEEVKSITKERKV 1204

Query: 305  VGNGKQRHVCYRDSKLTFLLR-DSLGGNAKTAI-IANVHPGSRCFGETLSTLNFAQRAKL 362
            +   ++     RD    ++   ++ G   K  + IA++H       E   T++  +R+  
Sbjct: 1205 LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIH-----LKEHQETIDELRRSVS 1259

Query: 363  IKNKAVVN-EDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEA 421
             K   ++N +D + + ++LQ E+  L E+           +  L   K+ +   E   E 
Sbjct: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEE-----------QELLPNVKEVSETQETMNEL 1308

Query: 422  MLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGF 481
             L  ++S  +  + + ++ ++E L L +           KF+E Q               
Sbjct: 1309 ELLTEQSTTKDSTTLARI-EMERLRLNE-----------KFQESQ--------------- 1341

Query: 482  LPEEQDRLLSELRNEIQTLREQIE-HHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMD 540
               E+ + L++ R+ ++T++E +E  H ++ ++  E  +  +E++  +  E     +E D
Sbjct: 1342 ---EEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQ--EQSLNMKEKD 1396

Query: 541  AQT---IAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNN 597
             +T   ++++E+   + S + + +    G S + Q+      +  K K  L ++Q  L +
Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQS 1456

Query: 598  -SKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETL 656
             S Q  E  KE+  K  LE E EL+                  C +++   +N++     
Sbjct: 1457 ESDQLKENIKEIVAKH-LETEEELK--------------VAHCCLKEQEETINELRVN-- 1499

Query: 657  KIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAIS 716
                               LS +     ++  Q  +I  ND L   +  E+ E+  +   
Sbjct: 1500 -------------------LSEKETEISTIQKQLEAI--NDKLQNKIQ-EIYEKEEQFNI 1537

Query: 717  EELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERID-WTKQQEEL 775
            +++  VQE+++ L+   +  + K+  LQ    K+   + ++QE  S E I    K++EE+
Sbjct: 1538 KQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQE--SQEEIQIMIKEKEEM 1595

Query: 776  LSQLNVLEKQLQET-QTKNDFLKSEVHDLRVVL-HSADKELSSVKLEYSSFKTNQEK--E 831
                    K++QE  Q + D LK    ++   +  S +KE   +K+  ++    QEK  E
Sbjct: 1596 --------KRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKM--TAVNETQEKMCE 1645

Query: 832  FNKLSERHMHVQLQLDNLRLENEKL----------LESKACLQDSYDNLQEIMKFEIDQL 881
               L E+    +L L+N+  EN +L          + S    +D   +++E +K E DQL
Sbjct: 1646 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQL 1705

Query: 882  SRNLQ-----NFKKENET------LKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKE 930
              NL+     + +K+ E       LK     + +L     E+ N++S   ++D E+S+  
Sbjct: 1706 KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEIS-NMQKDLEHSNDA 1764

Query: 931  I----LKVLEAVR------QEKQKETAKC------------------EQQMAKVQKLEES 962
            +    LK+ E +R      +E+Q+   K                   E   AK+Q+  + 
Sbjct: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824

Query: 963  LLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSA 1022
            L A E  + +L+K  +  +K V+++    ++L+  + +++ T+  L+ E  ++  K +  
Sbjct: 1825 LKANEHQLITLKKDVNETQKKVSEM----EQLKKQIKDQSLTLSKLEIENLNLAQKLHEN 1880

Query: 1023 LVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHAT-------EQLNML 1075
            L   EE + ++K+++ ++  ++ETL+L       ERD L E L           ++L   
Sbjct: 1881 L---EEMKSVMKERD-NLRRVEETLKL-------ERDQLKESLQETKARDLEIQQELKTA 1929

Query: 1076 TEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSA 1135
               SK+H   +   +E++++K   I ++Q  L++ K+E+++K  E   K  QL  V    
Sbjct: 1930 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRV---- 1985

Query: 1136 AEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMK 1195
             ED        +    L K  E Q   ++  R        L  KL+E  E          
Sbjct: 1986 KEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNF---QLTKKLHESLEEIRIVAKERD 2042

Query: 1196 EQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLA 1255
            E  R  E+L++E  Q I         L ++  +   + Q  P+ + L + Q+   +    
Sbjct: 2043 ELRRIKESLKMERDQFI-------ATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLRE 2095

Query: 1256 KSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSK-LEE 1314
            K   ++E+LK  +++++    L    ++ L    E ++  ++  KA      L++K +E+
Sbjct: 2096 KCSRIKELLKRYSEMDDHYECLNRLSLD-LEKEIEFQKELSMRVKANLSLPYLQTKHIEK 2154

Query: 1315 MYEERERTSQEMEMLRKQVE 1334
            ++   +R S E   + K+++
Sbjct: 2155 LFTANQRCSMEFHRIMKKLK 2174



 Score =  117 bits (294), Expect = 6e-26
 Identities = 234/1156 (20%), Positives = 480/1156 (41%), Gaps = 156/1156 (13%)

Query: 363  IKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFL------------TRDKK 410
            +K+ A   +D Q     LQ+E  +LKE + E+ +     E  L            T ++ 
Sbjct: 1437 MKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL 1496

Query: 411  KTNYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFRED-QIIR 469
            + N  E   E     K+ E     L  K+ ++ +   K+E+F  + K I + +E    ++
Sbjct: 1497 RVNLSEKETEISTIQKQLEAINDKLQNKIQEIYE---KEEQF--NIKQISEVQEKVNELK 1551

Query: 470  LEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQI-------EHHPRVAKYAMENHSLRE 522
              K H++++   L   + ++L EL N +Q  +E+I       E   RV +         +
Sbjct: 1552 QFKEHRKAKDSALQSIESKML-ELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK 1610

Query: 523  ENRRLRLLEPVKRAQEMDAQ-----TIAKLEKAFSEISGMEKSDKNQQGFSPKAQKE--- 574
            EN +  ++  +K +QE + Q      + + ++   EI  +++  + Q+      + E   
Sbjct: 1611 ENTK-EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIR 1669

Query: 575  --PCLFANTEKLKA------QLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQ-- 624
                L  N E++++       L  ++  L   + + +E    T  R LE + EL+ +   
Sbjct: 1670 LTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMH 1729

Query: 625  -KANLNLENLLEATKACKRQEVSQLNK--------IHAETLKIITTPTKAYQLHSRPVPK 675
             K +    + L    + K  E+S + K        + A+ LKI     +   +H +   +
Sbjct: 1730 LKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKI-QEELRIAHMHLKEQQE 1788

Query: 676  LSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDE 735
               ++    S  T   S +  D+ N     +   Q  +A   +L T+++ ++  Q K+ E
Sbjct: 1789 TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE 1848

Query: 736  EEHKNLKLQQH---VDKLE----------HHSTQMQELFSSERIDWTKQQEELLSQLNVL 782
             E    +++     + KLE          H + +  +    ER +  + +E L  + + L
Sbjct: 1849 MEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQL 1908

Query: 783  EKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNK-LSERHMH 841
            ++ LQET+ ++  ++ E+   R+ L    KE      E  S KT Q  +  K L +    
Sbjct: 1909 KESLQETKARDLEIQQELKTARM-LSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE 1967

Query: 842  VQLQLDNLRLENEKLLESKACLQDSYDNLQEI--MKFEIDQLSRNLQNFKKENETLKSDL 899
            +Q ++  L+ +  +LL  K  +  S+  + E+  +K + +  + ++Q+ + +N  L   L
Sbjct: 1968 LQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKL 2027

Query: 900  NNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAK--VQ 957
            +  +E +    +  ++L    E  K    + I  + E + +++Q    K E+++     Q
Sbjct: 2028 HESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQ 2087

Query: 958  KLEESLLAT-EKVISSLEKSRDSD------KKVVADLMNQIQ----------------EL 994
             L ESL     ++   L++  + D       ++  DL  +I+                 L
Sbjct: 2088 HLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYL 2147

Query: 995  RTSVCEKTETIDT-----LKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKET--- 1046
            +T   EK  T +        + +K +    +     +EE    I K E+D +D  E    
Sbjct: 2148 QTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKE 2207

Query: 1047 --LRLRILSEDIE------RDMLCE---DLAHATEQLNMLTEASKKHSGLLQSAQEELTK 1095
              ++++ L +D +      RD+      DL H  E L   +E+  +   +    Q+ L+ 
Sbjct: 2208 LLIKIQHLQQDCDVPSRELRDLKLNQNMDL-HIEEILKDFSES--EFPSIKTEFQQVLSN 2264

Query: 1096 KEALIQELQHKLN-----QKKEEVEQKKNEY-----NFKMRQLEHVMDSAAE-DPQSPKT 1144
            ++ + Q L+  LN     +K +   QK+N+      NF   ++  +M+ + E + +S   
Sbjct: 2265 RKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATI 2324

Query: 1145 PPHFQTHLAKLLETQEQEIEDGRASKTSLE-----HLVTKLNEDREVKNAEILRMKEQLR 1199
               ++  L  L E  E+  ++ +  KTSL      +  T+ N++  V +       E++R
Sbjct: 2325 SKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIR 2384

Query: 1200 EMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQN----------HPDNQQLKNEQEES 1249
            E+EN   E+     K   +  +   IK QKE    N          H  N+ L+  +E  
Sbjct: 2385 ELENSLHEA-----KESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETI 2439

Query: 1250 IKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQ-EKEQL 1308
               ++ + K+       K ++E+++  L   ++E ++   E E+  +      + +KE +
Sbjct: 2440 ---QVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVI 2496

Query: 1309 RSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAE 1368
            R   E +   R + +Q+  ++ +  +          G  +   +    + LK E++RL +
Sbjct: 2497 RLLRENL--RRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEK 2554

Query: 1369 ETEKLRAENVFLKEKK 1384
            E  KL+ +N  L ++K
Sbjct: 2555 EISKLKQQNEQLIKQK 2570



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 143/708 (20%), Positives = 304/708 (42%), Gaps = 101/708 (14%)

Query: 349  ETLSTLNFAQRAKLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRD 408
            +T   L+   +  + K +  ++E T   +S +Q ++ + K++L +        E  L R 
Sbjct: 1927 KTARMLSKEHKETVDKLREKISEKTI-QISDIQKDLDKSKDELQKKIQELQKKELQLLRV 1985

Query: 409  K-------KKTNYMEY----FQEAMLFFKKSEQEKKSLIEKVTQ-LEDLTL--KKEKFIQ 454
            K       KK N ME     F+   L  +    +   L +K+ + LE++ +  K+   ++
Sbjct: 1986 KEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELR 2045

Query: 455  SNKMIVKFREDQIIR-LEKLHKESRGGFLPEEQDRLLSELRNEI-QTLREQIEHHPRVAK 512
              K  +K   DQ I  L ++    R     + + RLLS+ +  + ++LRE+      + K
Sbjct: 2046 RIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLK 2105

Query: 513  Y--AMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPK 570
                M++H        L L + ++  +E+  +  A L   + +   +EK     Q  S +
Sbjct: 2106 RYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSME 2165

Query: 571  AQKEPCLFANTEKLKAQLLQIQTELNNSKQEYE-EFKELTRKRQLELESELQSLQ----- 624
              +   +    + + + + +I+ E + S  ++E +F +   K Q EL  ++Q LQ     
Sbjct: 2166 FHR---IMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEK-QKELLIKIQHLQQDCDV 2221

Query: 625  --------KANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQ-----LHSR 671
                    K N N++  L   +  K    S+   I  E  ++++   +  Q     L++R
Sbjct: 2222 PSRELRDLKLNQNMD--LHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTR 2279

Query: 672  -PVPKLSPEMGSFGSLYTQNSSILD-NDILNEPVPPEMNEQAFEAISEELRTVQEQMSAL 729
              + KL         +  +N  I   N+  N  +   MNE           T  E+ SA 
Sbjct: 2280 FDIEKLK------NGIQKENDRICQVNNFFNNRIIAIMNES----------TEFEERSAT 2323

Query: 730  QAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQET 789
             +K  E++ K+LK +++    +++ T    L S  +++ T Q  +     +V  +  Q T
Sbjct: 2324 ISKEWEQDLKSLK-EKNEKLFKNYQTLKTSLASGAQVNPTTQDNK---NPHVTSRATQLT 2379

Query: 790  QTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQ--EKEFNKLSERHMHVQLQLD 847
              K   L++ +H+ +    +  KE   +K++     TN    K   K+ E +  ++   +
Sbjct: 2380 TEKIRELENSLHEAKE--SAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKE 2437

Query: 848  NLRLENEKL-LESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELL 906
             +++  +K+ L +K   ++  D   +++K +++++ +N + F+KE    K+ +    E++
Sbjct: 2438 TIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKM-KNAKEFEKEISATKATVEYQKEVI 2496

Query: 907  EAEKERNNKLSLQFEE--------DKENSSKEIL-------------KVLEAVRQEKQKE 945
               +E N + S Q ++        D + S+K +               +L++     +KE
Sbjct: 2497 RLLRE-NLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKE 2555

Query: 946  TAKCEQQMAKVQKLEESLLATEKVISSLEKS-------RDSDKKVVAD 986
             +K +QQ  ++ K +  LL+  + +S+  K+       R++ K+V  +
Sbjct: 2556 ISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCE 2603



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 131/618 (21%), Positives = 242/618 (39%), Gaps = 96/618 (15%)

Query: 384  VKRLKEQLA-ELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKKSLIEKVTQL 442
            +  L+E +A +  + Q  PE  L  D ++ +  E  +E     K+  +    + +    L
Sbjct: 2059 IATLREMIARDRQNHQVKPEKRLLSDGQQ-HLTESLREKCSRIKELLKRYSEMDDHYECL 2117

Query: 443  EDLTLKKEKFIQSNK---MIVKFRED----QIIRLEKLHKESRGGFLPEEQDRLLSELRN 495
              L+L  EK I+  K   M VK        Q   +EKL   ++   +  E  R++ +L+ 
Sbjct: 2118 NRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSM--EFHRIMKKLKY 2175

Query: 496  EIQTLRE-QIEHHPRVAKYAMENHSLREENRRL---------------RLLEPVKRAQEM 539
             +  + + + E H  + K+ M+     E+ + L               R L  +K  Q M
Sbjct: 2176 VLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNM 2235

Query: 540  DAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCL--FANT----EKLKA------- 586
            D   I ++ K FSE        + QQ  S + +    L  + NT    EKLK        
Sbjct: 2236 DLH-IEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEND 2294

Query: 587  QLLQIQTELNNS----KQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKR 642
            ++ Q+    NN       E  EF+E +     E E +L+SL++ N   E L +       
Sbjct: 2295 RICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKN---EKLFK------- 2344

Query: 643  QEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGS-LYTQNSSILDNDILNE 701
                     + +TLK  T+     Q++       +P + S  + L T+    L+N +   
Sbjct: 2345 ---------NYQTLK--TSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEA 2393

Query: 702  PVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEE----EHKNLKLQQHVDKLEHHSTQM 757
                   E     + +EL    + ++ LQAK+ E     E     +Q   DK+   +   
Sbjct: 2394 KESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPY 2453

Query: 758  QELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSV 817
            +E     ++   K   E +      EK++  T+   ++ K  +  LR  L          
Sbjct: 2454 KEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLR--------- 2504

Query: 818  KLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLE---NEKLLESKACLQDSYDNLQEIM 874
                   ++ Q ++ + +SE   H   Q  N  L       ++++   L    ++++  +
Sbjct: 2505 -------RSQQAQDTSVISE---HTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIR--L 2552

Query: 875  KFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKV 934
            + EI +L +  +   K+   L S+  +L   ++  KER  K     +   ENS K   KV
Sbjct: 2553 EKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKS-PKV 2611

Query: 935  LEAVRQEKQKETAKCEQQ 952
                 ++KQ   ++C+++
Sbjct: 2612 TGTASKKKQITPSQCKER 2629


>gi|116686122 kinesin family member 4 [Homo sapiens]
          Length = 1232

 Score =  315 bits (808), Expect = 1e-85
 Identities = 296/1033 (28%), Positives = 493/1033 (47%), Gaps = 116/1033 (11%)

Query: 23  EGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPEPKTFTFDHVADVDTTQ 82
           +G  ++V +R RP   +  S +G Q +CLS +      +      K+FT+D V D  T Q
Sbjct: 6   KGIPVRVALRCRPLVPKEIS-EGCQ-MCLSFVPGEPQVVVGTD--KSFTYDFVFDPSTEQ 61

Query: 83  ESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEY 142
           E VF T    +++    GYN T+ AYGQTGSGKT++M G   ++  +    GVIPR  + 
Sbjct: 62  EEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGVIPRVIQL 121

Query: 143 LFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLL--DSASAGLYLREHIKKGVFVVGA 200
           LF  ID++ +       F  K S++EIYNE+I DLL      A + +RE  K+G+ +VG 
Sbjct: 122 LFKEIDKKSD-----FEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGL 176

Query: 201 VEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNEIVNIRTSL 260
            E+ V  A +    L  G  +R VAST+MN +SSRSHA+FTI++E  +KS++  + R S 
Sbjct: 177 TEKTVLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISLEQRKKSDKNSSFR-SK 235

Query: 261 LNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDSKL 320
           L+LVDLAGSERQK T AEG RLKE  NINR L CLG VI+AL D  + K   V YRDSKL
Sbjct: 236 LHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGD--DKKGGFVPYRDSKL 293

Query: 321 TFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNVSQL 380
           T LL+DSLGGN+ T +IA V P      ETL+TL +A RA+ IKNK +VN D Q      
Sbjct: 294 TRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIVNIDPQ------ 347

Query: 381 QAEVKRLKEQLAEL------ASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKKS 434
            AE+  LK+Q+ +L      A G T P S      +  N     ++     +++E+  + 
Sbjct: 348 TAELNHLKQQVQQLQVLLLQAHGGTLPGSITVEPSE--NLQSLMEKNQSLVEENEKLSRG 405

Query: 435 LIEKVTQ----LEDLTLKKEKFIQSNKMIVKFREDQIIR--LEKLHKESRGGFLPEEQD- 487
           L E   Q    LE + L ++   + N  + + R+    +  L+KL +      L E  + 
Sbjct: 406 LSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHAACKLDLQKLVETLEDQELKENVEI 465

Query: 488 -----RLLSELRNE--------IQTLRE---QIEHHPRVAKYA---MENHSLREENRRLR 528
                +L+++L +E        I T  E   Q+E  P  ++ +      H+LR+      
Sbjct: 466 ICNLQQLITQLSDETVACMAAAIDTAVEQEAQVETSPETSRSSDAFTTQHALRQAQMSKE 525

Query: 529 LLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQL 588
           L+E + +A  +      K+ +  S++  +      Q  +    ++      N +K K +L
Sbjct: 526 LVE-LNKALALKEALARKMTQNDSQLQPI------QYQYQDNIKELELEVINLQKEKEEL 578

Query: 589 -LQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQ 647
            L++QT   ++ Q   +  E  RKR  ELE ++  L+K               K  E S+
Sbjct: 579 VLELQTAKKDANQ--AKLSERRRKRLQELEGQIADLKK---------------KLNEQSK 621

Query: 648 LNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEM 707
           L K+   T + ++   +  ++      +L  +M      + Q     D +++   +    
Sbjct: 622 LLKLKESTERTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQ--LKERD 679

Query: 708 NEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFS----- 762
            ++ +E +  E R  Q+Q + L+ K +E    N +L+  + K    + + +E  S     
Sbjct: 680 RKRQYELLKLE-RNFQKQSNVLRRKTEEAAAANKRLKDALQKQREVADKRKETQSRGMEG 738

Query: 763 -SERI-DWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLE 820
            + R+ +W   + E++      ++ L +       L  +V  L+    S   E    KL 
Sbjct: 739 TAARVKNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQLKEKKESG--ENPPPKLR 796

Query: 821 YSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENE-----------KLL--ESKACLQDSY 867
             +F   + +   ++SE    +  Q+++L  E E           KLL  ES+   +  +
Sbjct: 797 RRTFSLTEVR--GQVSESEDSITKQIESLETEMEFRSAQIADLQQKLLDAESEDRPKQRW 854

Query: 868 DNLQEI------MKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFE 921
           +N+  I      +K+ I +L  +     K   +LK    +  ++ +   E  N     F 
Sbjct: 855 ENIATILEAKCALKYLIGELVSSKIQVSKLESSLKQSKTSCADMQKMLFEERN----HFA 910

Query: 922 EDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDK 981
           E +     E++++ +  +++     ++ +Q     ++LEES+   E+ + S  K +D + 
Sbjct: 911 EIETELQAELVRMEQQHQEKVLYLLSQLQQSQMAEKQLEESVSEKEQQLLSTLKCQDEEL 970

Query: 982 KVVADLMNQIQEL 994
           + + ++  Q Q+L
Sbjct: 971 EKMREVCEQNQQL 983



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 139/705 (19%), Positives = 274/705 (38%), Gaps = 108/705 (15%)

Query: 654  ETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQ-----------NSSILDNDILNEP 702
            ETL  +    +A ++ ++P+  + P+      L  Q           +   L   I  EP
Sbjct: 322  ETLNTLRYADRARKIKNKPIVNIDPQTAELNHLKQQVQQLQVLLLQAHGGTLPGSITVEP 381

Query: 703  VPP-----EMNEQAFEA---ISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHS 754
                    E N+   E    +S  L     Q + +  ++   E  N K+   +++L  H+
Sbjct: 382  SENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHA 441

Query: 755  T---QMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSAD 811
                 +Q+L  +      K+  E++  L  L  QL +          +      V   A 
Sbjct: 442  ACKLDLQKLVETLEDQELKENVEIICNLQQLITQLSDETVACMAAAIDT----AVEQEAQ 497

Query: 812  KELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSY---- 867
             E S      S   T Q    + L +  M  +L   N  L  ++ L  K    DS     
Sbjct: 498  VETSPETSRSSDAFTTQ----HALRQAQMSKELVELNKALALKEALARKMTQNDSQLQPI 553

Query: 868  -----DNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEE 922
                 DN++E+ + E+  L +  +    E +T K D N   +L E  ++R  +L  Q  +
Sbjct: 554  QYQYQDNIKEL-ELEVINLQKEKEELVLELQTAKKDANQA-KLSERRRKRLQELEGQIAD 611

Query: 923  DK-------------ENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKV 969
             K             E++ + + K+ + +R  K +      Q     +K  +     +K 
Sbjct: 612  LKKKLNEQSKLLKLKESTERTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQKKDKE 671

Query: 970  ISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREES 1029
            +  L++     +  +  L    Q+    +  KTE      + LKD   K       R+E+
Sbjct: 672  VIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQREVADKRKET 731

Query: 1030 R--------VLIKK---QEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEA 1078
            +          +K     E++++   E  +  +     +R +L +D+A   E        
Sbjct: 732  QSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQLKE-------- 783

Query: 1079 SKKHSGLLQSAQEELTKKEALIQELQHKLNQKKE----EVEQKKNEYNFKMRQLEHVMDS 1134
             KK SG  ++   +L ++   + E++ ++++ ++    ++E  + E  F+  Q+  +   
Sbjct: 784  -KKESG--ENPPPKLRRRTFSLTEVRGQVSESEDSITKQIESLETEMEFRSAQIADLQQK 840

Query: 1135 AAEDPQSPKTPPHFQTHLAKLLET----------------QEQEIEDG-RASKTSLEHLV 1177
               D +S   P     ++A +LE                 Q  ++E   + SKTS   + 
Sbjct: 841  LL-DAESEDRPKQRWENIATILEAKCALKYLIGELVSSKIQVSKLESSLKQSKTSCADMQ 899

Query: 1178 TKLNEDR----EVK---NAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKE 1230
              L E+R    E++    AE++RM++Q +E + L L SQ  ++++ + + QL++   +KE
Sbjct: 900  KMLFEERNHFAEIETELQAELVRMEQQHQE-KVLYLLSQ--LQQSQMAEKQLEESVSEKE 956

Query: 1231 NSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQS 1275
                +    Q  + E+   + E+  +     E++K K  L +V S
Sbjct: 957  QQLLSTLKCQDEELEKMREVCEQNQQLLRENEIIKQKLTLLQVAS 1001



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 107/534 (20%), Positives = 222/534 (41%), Gaps = 90/534 (16%)

Query: 921  EEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDS- 979
            + DK +S +  L +++    E+QK+T     ++ +   +   LL    VIS+L   +   
Sbjct: 225  KSDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGG 284

Query: 980  -----DKKVVADLMNQIQ-ELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLI 1033
                 D K+   L + +     T +       D+  +E  +     + A   + +  V I
Sbjct: 285  FVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIVNI 344

Query: 1034 KKQEVDILDLKETLR-LRILSEDIERDML--------CEDLAHATEQLNMLTEASKKHS- 1083
              Q  ++  LK+ ++ L++L        L         E+L    E+   L E ++K S 
Sbjct: 345  DPQTAELNHLKQQVQQLQVLLLQAHGGTLPGSITVEPSENLQSLMEKNQSLVEENEKLSR 404

Query: 1084 GLLQSAQE--ELTKKEALIQELQHKLNQKKEEVEQ--------------------KKN-E 1120
            GL ++A +  ++ ++  L ++   K+N K EE+ Q                    K+N E
Sbjct: 405  GLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHAACKLDLQKLVETLEDQELKENVE 464

Query: 1121 YNFKMRQL------------EHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRA 1168
                ++QL               +D+A E     +T P  +T  +    T +  +   + 
Sbjct: 465  IICNLQQLITQLSDETVACMAAAIDTAVEQEAQVETSP--ETSRSSDAFTTQHALRQAQM 522

Query: 1169 SKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQ 1228
            SK  +E     LN+   +K A   +M +   +++ ++ + Q  I++   L+ ++ +++++
Sbjct: 523  SKELVE-----LNKALALKEALARKMTQNDSQLQPIQYQYQDNIKE---LELEVINLQKE 574

Query: 1229 KEN---------SDQNHPDNQQLKNEQEESIKERLA--KSKIVEE--MLKMKADLEEVQS 1275
            KE           D N     + + ++ + ++ ++A  K K+ E+  +LK+K   E   S
Sbjct: 575  KEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSKLLKLKESTERTVS 634

Query: 1276 ALY-------NKEMECLR-MTDEVER----TQTLESKAFQEKEQLRSKLEEMYEERERTS 1323
             L        N+ ++ +R M ++ E+     Q  + +  Q KE+ R +  E+ +      
Sbjct: 635  KLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQ 694

Query: 1324 QEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAEN 1377
            ++  +LR++ E  A  N +L   ++  QK + V   +KE      E    R +N
Sbjct: 695  KQSNVLRRKTEEAAAANKRL---KDALQKQREVADKRKETQSRGMEGTAARVKN 745


>gi|150010604 kinesin family member 4B [Homo sapiens]
          Length = 1234

 Score =  304 bits (779), Expect = 3e-82
 Identities = 319/1082 (29%), Positives = 507/1082 (46%), Gaps = 185/1082 (17%)

Query: 23   EGDAIKVFVRIRPPAERSGSADGEQNLCLS-VLSSTSLRLHSNPEPKTFTFDHVADVDTT 81
            +G  ++V +R RP   +  S +G Q +CLS V   T + + ++   K+FT+D V D  T 
Sbjct: 6    KGIPVRVALRCRPLVPKEIS-EGCQ-MCLSFVPGETQVVVGTD---KSFTYDFVFDPCTE 60

Query: 82   QESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFE 141
            QE VF      +++    GYN T+ AYGQTGSGKT++M G   ++  +    G+IPR  +
Sbjct: 61   QEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGIIPRVIQ 120

Query: 142  YLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLL--DSASAGLYLREHIKKGVFVVG 199
             LF  ID++ +       F  K S++EIYNE+I DLL      A + +RE  K+G+ +VG
Sbjct: 121  LLFKEIDKKSD-----FEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVG 175

Query: 200  AVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNEIVNIRTS 259
              E+ V  A +    L  G  +R VAST+MN +SSRSHA+FTI+IE  +KS++  + R S
Sbjct: 176  LTEKTVLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKSDKNCSFR-S 234

Query: 260  LLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDSK 319
             L+LVDLAGSERQK T AEG RLKE  NINR L CLG VI+AL D  + K   V YRDSK
Sbjct: 235  KLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGD--DKKGSFVPYRDSK 292

Query: 320  LTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNVSQ 379
            LT LL+DSLGGN+ T +IA V P      ETLSTL +A RA+ IKNK +VN D       
Sbjct: 293  LTRLLQDSLGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVNIDPH----- 347

Query: 380  LQAEVKRLKEQLAEL------ASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKK 433
              AE+  LK+Q+ +L      A G T P S            E  Q  M       ++ +
Sbjct: 348  -TAELNHLKQQVQQLQVLLLQAHGGTLPGSI------NAEPSENLQSLM-------EKNQ 393

Query: 434  SLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRLLSEL 493
            SL+E+  +L     K     Q+ +M+     ++II  E+++         E+ +  L EL
Sbjct: 394  SLVEENEKLSRCLSKAAG--QTAQML-----ERIILTEQVN---------EKLNAKLEEL 437

Query: 494  RNEIQ---TLREQIEHHPRVAKYAMENHSLREENRRLRLLEPV--KRAQEMDAQTIAKLE 548
            R  +     L++ +E         +E+  L+E    +  L+ +  + + E  A T A ++
Sbjct: 438  RQHVACKLDLQKLVE--------TLEDQELKENVEIICNLQQLITQLSDETVACTAAAID 489

Query: 549  KAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKL-KAQLLQIQTELNNSKQEYEEFKE 607
             A  E + +E         SP+  +    F     L +AQ+ +   ELNN+       KE
Sbjct: 490  TAVEEEAQVET--------SPETSRSSDAFTTQHALHQAQMSKEVVELNNAL----ALKE 537

Query: 608  LTRKRQLELESELQSLQ-KANLNLENL-LEATKACKRQE--VSQLNKIHAETLKIITTPT 663
               ++  + +++LQ +Q +   N++NL LE     K +E  V +L     +T K      
Sbjct: 538  ALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEKEELVREL-----QTAKKNVNQA 592

Query: 664  KAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQ 723
            K  +   + + +L  ++        + S +L           E  E+    +++E+  ++
Sbjct: 593  KLSEHRHKLLQELEGQIADLKKKLNEQSKLLK--------LKESTERTVSKLNQEIWMMK 644

Query: 724  EQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLE 783
             Q   L  ++ E+  K  + +Q  DK      Q++E     + +  K +     Q +VL 
Sbjct: 645  NQRVQLMRQMKEDAEKFRQWKQKKDK---EVIQLKERDRKRQYELLKLERNFQKQSSVLR 701

Query: 784  KQLQETQTKNDFLKS------EVHDLRVVLHSADKELSSVK--------LEYSSFKTNQE 829
            ++ +E    N  LK       EV D R    S  KE  + +        +E        +
Sbjct: 702  RKTEEAAAANKRLKDALQKQREVTDKRKETQSHGKEGIAARVRNWLGNEIEVMVSTEEAK 761

Query: 830  KEFNKLSERHMHVQLQLDNLRLENE---------------------KLLESKACLQDSYD 868
            +  N L E    +   +  L+ + E                     ++LES+ C+    +
Sbjct: 762  RHLNDLLEDRKILAQDVVQLKEKKESRENPPPKLRKCTFSLSEVHGQVLESEDCITKQIE 821

Query: 869  NLQ---EIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAE---------------- 909
            +L+   E+   +I  L + L + + E+   K    N+  +LEA+                
Sbjct: 822  SLETEMELRSAQIADLQQKLLDAESEDRP-KQCWENIATILEAKCALKYLIGELVSSKIH 880

Query: 910  ------KERNNKLS------LQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQ 957
                    R +K S      + FEE    S  E     E VR E+Q +    E+ +  V 
Sbjct: 881  VTKLENSLRQSKASCADMQKMLFEEQNHFSEIETELQAELVRMEQQHQ----EKVLYLVS 936

Query: 958  KLEESLLATEKVISSLEKS-RDSDKKVVADLMNQIQELR--TSVCEKTETI----DTLKQ 1010
            +L+ES +A ++    LEKS  + ++++V+ L  Q +EL     VCE+ + +    + +KQ
Sbjct: 937  QLQESQMAEKQ----LEKSASEKEQQLVSTLQCQDEELEKMREVCEQNQQLLQENEIIKQ 992

Query: 1011 EL 1012
            +L
Sbjct: 993  KL 994



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 135/706 (19%), Positives = 287/706 (40%), Gaps = 80/706 (11%)

Query: 654  ETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQ-----------NSSILDNDILNEP 702
            ETL  +    +A ++ ++P+  + P       L  Q           +   L   I  EP
Sbjct: 322  ETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQVQQLQVLLLQAHGGTLPGSINAEP 381

Query: 703  VPP-----EMNEQAFEA---ISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHH- 753
                    E N+   E    +S  L     Q + +  ++   E  N KL   +++L  H 
Sbjct: 382  SENLQSLMEKNQSLVEENEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEELRQHV 441

Query: 754  --STQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDF--LKSEVHDLRVVLHS 809
                 +Q+L  +      K+  E++  L  L  QL +         + + V +   V  S
Sbjct: 442  ACKLDLQKLVETLEDQELKENVEIICNLQQLITQLSDETVACTAAAIDTAVEEEAQVETS 501

Query: 810  ADKELSS--VKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSY 867
             +   SS     +++  +    KE  +L+      +  +  +   + +L   +   QD+ 
Sbjct: 502  PETSRSSDAFTTQHALHQAQMSKEVVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNI 561

Query: 868  DNLQ-EIMKF--EIDQLSRNLQNFKKE--NETLKSDLNNLMELLEAE----KERNNKLSL 918
             NL+ E++    E ++L R LQ  KK      L    + L++ LE +    K++ N+ S 
Sbjct: 562  KNLELEVINLQKEKEELVRELQTAKKNVNQAKLSEHRHKLLQELEGQIADLKKKLNEQS- 620

Query: 919  QFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRD 978
            +  + KE++ + + K+ + +   K +      Q     +K  +     +K +  L++   
Sbjct: 621  KLLKLKESTERTVSKLNQEIWMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDR 680

Query: 979  SDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEV 1038
              +  +  L    Q+  + +  KTE      + LKD   K       R+E++   K+   
Sbjct: 681  KRQYELLKLERNFQKQSSVLRRKTEEAAAANKRLKDALQKQREVTDKRKETQSHGKEGIA 740

Query: 1039 DILD--LKETLRLRILSEDIERDM--LCED---LAHATEQLNMLTEASKKHSGLLQSAQE 1091
              +   L   + + + +E+ +R +  L ED   LA    QL    E+ +     L+    
Sbjct: 741  ARVRNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVVQLKEKKESRENPPPKLRKCTF 800

Query: 1092 ELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEH-VMDSAAEDPQSPKTPPHFQT 1150
             L++    + E +  + ++ E +E +    + ++  L+  ++D+ +ED      P     
Sbjct: 801  SLSEVHGQVLESEDCITKQIESLETEMELRSAQIADLQQKLLDAESED-----RPKQCWE 855

Query: 1151 HLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQ 1210
            ++A +LE           +K +L++L+ +L   +      + +++  LR+ +    + Q+
Sbjct: 856  NIATILE-----------AKCALKYLIGELVSSK----IHVTKLENSLRQSKASCADMQK 900

Query: 1211 LI--EKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKA 1268
            ++  E+N   + +  +++ +    +Q H        E+   +  +L +S++ E+ L+  A
Sbjct: 901  MLFEEQNHFSEIE-TELQAELVRMEQQH-------QEKVLYLVSQLQESQMAEKQLEKSA 952

Query: 1269 DLEEVQ--SALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKL 1312
              +E Q  S L  ++ E  +M +  E+ Q L     QE E ++ KL
Sbjct: 953  SEKEQQLVSTLQCQDEELEKMREVCEQNQQL----LQENEIIKQKL 994



 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 105/533 (19%), Positives = 208/533 (39%), Gaps = 88/533 (16%)

Query: 921  EEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSD 980
            + DK  S +  L +++    E+QK+T     ++ +   +   LL    VIS+L   +   
Sbjct: 225  KSDKNCSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGS 284

Query: 981  KKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDI 1040
                 D     + L+ S+   + T+        D N +   + +   +    IK + +  
Sbjct: 285  FVPYRD-SKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVN 343

Query: 1041 LDLKETLRLRILSEDIERDMLC------------------EDLAHATEQLNMLTEASKKH 1082
            +D   T  L  L + +++  +                   E+L    E+   L E ++K 
Sbjct: 344  ID-PHTAELNHLKQQVQQLQVLLLQAHGGTLPGSINAEPSENLQSLMEKNQSLVEENEKL 402

Query: 1083 SGLLQSAQ---EELTKKEALIQELQHKLNQKKEEVEQ--------------------KKN 1119
            S  L  A     ++ ++  L +++  KLN K EE+ Q                    K+N
Sbjct: 403  SRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEELRQHVACKLDLQKLVETLEDQELKEN 462

Query: 1120 -EYNFKMRQL------------EHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDG 1166
             E    ++QL               +D+A E+    +T P  +T  +    T +  +   
Sbjct: 463  VEIICNLQQLITQLSDETVACTAAAIDTAVEEEAQVETSP--ETSRSSDAFTTQHALHQA 520

Query: 1167 RASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWL----LQGQL 1222
            + SK      V +LN    +K A + +M +   +++ ++ + Q  I+   L    LQ + 
Sbjct: 521  QMSKE-----VVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEK 575

Query: 1223 DDIKRQKENSDQN------HPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSA 1276
            +++ R+ + + +N           +L  E E  I +   K     ++LK+K   E   S 
Sbjct: 576  EELVRELQTAKKNVNQAKLSEHRHKLLQELEGQIADLKKKLNEQSKLLKLKESTERTVSK 635

Query: 1277 LY-------NKEMECLR-MTDEVER----TQTLESKAFQEKEQLRSKLEEMYEERERTSQ 1324
            L        N+ ++ +R M ++ E+     Q  + +  Q KE+ R +  E+ +      +
Sbjct: 636  LNQEIWMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQK 695

Query: 1325 EMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAEN 1377
            +  +LR++ E  A  N +L   ++  QK + V   +KE     +E    R  N
Sbjct: 696  QSSVLRRKTEEAAAANKRL---KDALQKQREVTDKRKETQSHGKEGIAARVRN 745



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 104/554 (18%), Positives = 221/554 (39%), Gaps = 83/554 (14%)

Query: 889  KKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDK-ENSSKEILKVLEAVRQEKQKETA 947
            ++ENE     +  +++LL  E ++ +      +    E  ++EIL +L   R++ Q    
Sbjct: 105  EQENEPTVGIIPRVIQLLFKEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIR 164

Query: 948  KCEQQMAKVQKL-EESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETID 1006
            +  ++  K+  L E+++L     +S LE+  +S + V +  MN     ++S      TI 
Sbjct: 165  EDPKEGIKIVGLTEKTVLVALDTVSCLEQGNNS-RTVASTAMNS----QSSRSHAIFTIS 219

Query: 1007 TLKQELKDINCKYNSAL--VDREESRVLIKKQEVDILDLKETLRLR-------------- 1050
              +++  D NC + S L  VD   S    KK + +   LKE + +               
Sbjct: 220  IEQRKKSDKNCSFRSKLHLVDLAGSERQ-KKTKAEGDRLKEGININRGLLCLGNVISALG 278

Query: 1051 -------ILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQS---------AQEELT 1094
                   +   D +   L +D         M+   S   S L ++         A++   
Sbjct: 279  DDKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKN 338

Query: 1095 KKEALIQELQHKLNQKKEEVEQKK----------------NEYNFKMRQLEHVMDSAAED 1138
            K    I     +LN  K++V+Q +                 E +  ++ L     S  E+
Sbjct: 339  KPIVNIDPHTAELNHLKQQVQQLQVLLLQAHGGTLPGSINAEPSENLQSLMEKNQSLVEE 398

Query: 1139 PQS-----PKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILR 1193
             +       K        L +++ T++   +     +   +H+  KL+  + V+  E   
Sbjct: 399  NEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEELRQHVACKLDLQKLVETLEDQE 458

Query: 1194 MKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKER 1253
            +KE +  + NL+    QL ++         D   ++E   +  P+    ++    + +  
Sbjct: 459  LKENVEIICNLQQLITQLSDETVACTAAAIDTAVEEEAQVETSPETS--RSSDAFTTQHA 516

Query: 1254 LAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLE 1313
            L ++++ +E++       E+ +AL  KE    +MT    + Q ++ +     + L  ++ 
Sbjct: 517  LHQAQMSKEVV-------ELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVI 569

Query: 1314 EMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKL 1373
             + +E+E   +E++  +K V        KL  H+  H+ +Q +        ++A+  +KL
Sbjct: 570  NLQKEKEELVRELQTAKKNV-----NQAKLSEHR--HKLLQEL------EGQIADLKKKL 616

Query: 1374 RAENVFLKEKKRSE 1387
              ++  LK K+ +E
Sbjct: 617  NEQSKLLKLKESTE 630


>gi|46852174 kinesin family member 3A [Homo sapiens]
          Length = 699

 Score =  301 bits (771), Expect = 3e-81
 Identities = 233/617 (37%), Positives = 335/617 (54%), Gaps = 58/617 (9%)

Query: 25  DAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLH----SNPEPKTFTFDHVADVDT 80
           D +KV VR RP  ER  S   +Q + +  +  T + +H    SN  PKTFTFD V   ++
Sbjct: 13  DNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGT-ITVHKTDSSNEPPKTFTFDTVFGPES 71

Query: 81  TQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSF 140
            Q  V+   A+ I++S + GYNGTIFAYGQTG+GKTFTM G          LRG+IP SF
Sbjct: 72  KQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPE----LRGIIPNSF 127

Query: 141 EYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDS-ASAGLYLREHIKKGVFVVG 199
            ++F  I     KA     FL + S++EIYNE++ DLL    +  L ++E    GV++  
Sbjct: 128 AHIFGHI----AKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKD 183

Query: 200 AVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNE-IVNIRT 258
               VV +A +  ++++ G +NR V +T+MN  SSRSHA+FTITIE  EK  +  +++R 
Sbjct: 184 LSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRM 243

Query: 259 SLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDS 318
             L+LVDLAGSERQ  T A G RLKEA  IN SLS LG VI+ALVD   GK  HV YR+S
Sbjct: 244 GKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVD---GKSTHVPYRNS 300

Query: 319 KLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQ-GNV 377
           KLT LL+DSLGGN+KT + AN+ P    + ET+STL +A RAK IKNKA +NED +   +
Sbjct: 301 KLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALL 360

Query: 378 SQLQAEVKRLKEQL--AELASGQTPPESFLTRD------------KKKTNYMEYFQEAML 423
            Q Q E++ LK++L   E  SG     S    D            KK+    +   + M+
Sbjct: 361 RQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRKKRRGKKKVSPDKMI 420

Query: 424 FFK-KSEQEKKSLIEKVTQLEDLTLK-KEKFIQSNKMIVKFREDQIIRLEKL----HKES 477
             + K ++E+K+L  K+   E+   K + +  +  K ++K +++    LEKL     K  
Sbjct: 421 EMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVI 480

Query: 478 RGGF----LPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPV 533
            GG       EEQ++LL E   E++  R++ E   R  +         +E  RL + E  
Sbjct: 481 VGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELE--------EKEQERLDIEEKY 532

Query: 534 KRAQEMDAQTIAKLEKAFSEI--SGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQL-LQ 590
              QE       KL+K ++ +  +  E +D  Q+      ++   L  N  +L  +L LQ
Sbjct: 533 TSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQE----HQREIEGLLENIRQLSRELRLQ 588

Query: 591 IQTELNNSKQEYEEFKE 607
           +    N   ++Y+E  E
Sbjct: 589 MLIIDNFIPRDYQEMIE 605



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 77/371 (20%), Positives = 158/371 (42%), Gaps = 59/371 (15%)

Query: 932  LKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDS-----DKKVVAD 986
            L +++    E+Q +T    Q++ +  K+  SL     VIS+L   + +     + K+   
Sbjct: 246  LHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRL 305

Query: 987  LMNQI-QELRTSVCEK--------TETIDTLKQELKDINCKYNSALVDREESRVLIKKQE 1037
            L + +    +T +C           ETI TL+   +  N K N A ++ +    L+++ +
Sbjct: 306  LQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIK-NKARINEDPKDALLRQFQ 364

Query: 1038 VDILDLKETLR--LRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTK 1095
             +I +LK+ L     I   DI      E+      ++    E  KK  G  + + +++ +
Sbjct: 365  KEIEELKKKLEEGEEISGSDISGS---EEDDDEEGEVGEDGEKRKKRRGKKKVSPDKMIE 421

Query: 1096 KEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKL 1155
             +A I E +  L  K +  E+++N+   ++ + E  +  A ++ QS          L + 
Sbjct: 422  MQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQS----------LLEK 471

Query: 1156 LETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKN 1215
            L   E+++  G         L+ K  E            +E+L E  N+ LE +      
Sbjct: 472  LSALEKKVIVGGVD------LLAKAEE------------QEKLLEESNMELEER------ 507

Query: 1216 WLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEML-KMKADLEEVQ 1274
               + + + ++R+ E  +Q   D ++     +E  + +  K K V  ML   K+++ ++Q
Sbjct: 508  ---RKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQ 564

Query: 1275 SALYNKEMECL 1285
               + +E+E L
Sbjct: 565  QE-HQREIEGL 574



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 67/335 (20%), Positives = 153/335 (45%), Gaps = 51/335 (15%)

Query: 1021 SALVDREESRVLIKKQEVDILDLKETLRLRILSEDI---ERDMLCEDLAHAT----EQLN 1073
            SALVD + + V  +  ++           R+L + +    + M+C ++  A     E ++
Sbjct: 285  SALVDGKSTHVPYRNSKLT----------RLLQDSLGGNSKTMMCANIGPADYNYDETIS 334

Query: 1074 MLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMD 1133
             L  A++  + +   A+     K+AL+++ Q ++ + K+++E+ +      +   E   D
Sbjct: 335  TLRYANRAKN-IKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDD 393

Query: 1134 SAAE----DPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNA 1189
               E      +  K     +    K++E Q +  E+ +A       L TKL+ + E +N 
Sbjct: 394  EEGEVGEDGEKRKKRRGKKKVSPDKMIEMQAKIDEERKA-------LETKLDMEEEERNK 446

Query: 1190 EILRMKEQLREMENLRLESQQLIEKNWLLQ-----GQLDDIKRQKENSDQNHPDNQQLKN 1244
                ++++ +++   + E Q L+EK   L+     G +D + + +E        N +L+ 
Sbjct: 447  ARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEE 506

Query: 1245 EQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQE 1304
             ++ +  E+L +   +EE  + + D+EE  ++L   + E    T ++++  T+   A   
Sbjct: 507  RRKRA--EQLRRE--LEEKEQERLDIEEKYTSL---QEEAQGKTKKLKKVWTMLMAA--- 556

Query: 1305 KEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEE 1339
                +S++ ++ +E +R   E+E L + +  L+ E
Sbjct: 557  ----KSEMADLQQEHQR---EIEGLLENIRQLSRE 584



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 45/211 (21%), Positives = 95/211 (45%), Gaps = 38/211 (18%)

Query: 1179 KLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPD 1238
            ++NED   K+A + + ++++ E++    E +++            DI   +E+ D+    
Sbjct: 350  RINEDP--KDALLRQFQKEIEELKKKLEEGEEISGS---------DISGSEEDDDEEGEV 398

Query: 1239 NQQLKNEQEESIKERLAKSKIVE---------EMLKMKADLEE-----VQSALYNKEMEC 1284
             +  +  ++   K++++  K++E         + L+ K D+EE      ++ L  +E + 
Sbjct: 399  GEDGEKRKKRRGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDL 458

Query: 1285 LRMTDE----VERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEEN 1340
            L+   E    +E+   LE K       L +K EE  +  E ++ E+E  RK+ E L  E 
Sbjct: 459  LKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRE- 517

Query: 1341 GKLVGHQNLHQKIQYVVRLKKENVRLAEETE 1371
                    L +K Q  + ++++   L EE +
Sbjct: 518  --------LEEKEQERLDIEEKYTSLQEEAQ 540



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 32/147 (21%), Positives = 73/147 (49%), Gaps = 10/147 (6%)

Query: 722 VQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSS--ERIDWTKQQE-----E 774
           + E+  AL+ KLD EE +  K +  ++K E    + Q+   S  E++   +++      +
Sbjct: 426 IDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVD 485

Query: 775 LLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQE---KE 831
           LL++    EK L+E+  + +  +     LR  L   ++E   ++ +Y+S +   +   K+
Sbjct: 486 LLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKK 545

Query: 832 FNKLSERHMHVQLQLDNLRLENEKLLE 858
             K+    M  + ++ +L+ E+++ +E
Sbjct: 546 LKKVWTMLMAAKSEMADLQQEHQREIE 572



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 51/244 (20%), Positives = 107/244 (43%), Gaps = 24/244 (9%)

Query: 707 MNEQAFEAISEELRTVQEQMSALQAKLDEEEH---KNLKLQQHVDKLEHHSTQMQELFSS 763
           +NE   +A+   LR  Q+++  L+ KL+E E     ++   +  D  E    +  E    
Sbjct: 351 INEDPKDAL---LRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRKK 407

Query: 764 ERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSS 823
            R       ++++     ++++ +  +TK D  + E +  R  L   +K+L   + E+ S
Sbjct: 408 RRGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQS 467

Query: 824 FKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSR 883
                 ++ + L ++ +   + L     E EKLLE      +S   L+E  K   +QL R
Sbjct: 468 LL----EKLSALEKKVIVGGVDLLAKAEEQEKLLE------ESNMELEERRK-RAEQLRR 516

Query: 884 NLQNFKKENETLKSDLNNLMELLEAEKERNNKL-------SLQFEEDKENSSKEILKVLE 936
            L+  ++E   ++    +L E  + + ++  K+         +  + ++   +EI  +LE
Sbjct: 517 ELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLE 576

Query: 937 AVRQ 940
            +RQ
Sbjct: 577 NIRQ 580



 Score = 33.5 bits (75), Expect = 1.5
 Identities = 50/245 (20%), Positives = 95/245 (38%), Gaps = 32/245 (13%)

Query: 484 EEQDRLLSELRNEIQTLREQIEHHPRVAKYAM--------------ENHSLREENRRLRL 529
           + +D LL + + EI+ L++++E    ++   +              E+   R++ R  + 
Sbjct: 354 DPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRKKRRGKKK 413

Query: 530 LEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTE------K 583
           + P K   EM A+ I +  KA      ME+ ++N+     + +++  L A  E      K
Sbjct: 414 VSPDKMI-EMQAK-IDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEK 471

Query: 584 LKA----------QLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENL 633
           L A           LL    E     +E     E  RKR  +L  EL+  ++  L++E  
Sbjct: 472 LSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQERLDIEEK 531

Query: 634 LEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSI 693
             + +   + +  +L K+    +   +      Q H R +  L   +            I
Sbjct: 532 YTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLI 591

Query: 694 LDNDI 698
           +DN I
Sbjct: 592 IDNFI 596


>gi|4758646 kinesin family member 3B [Homo sapiens]
          Length = 747

 Score =  300 bits (768), Expect = 6e-81
 Identities = 229/620 (36%), Positives = 337/620 (54%), Gaps = 73/620 (11%)

Query: 25  DAIKVFVRIRPPAERSGSADGEQNLCLSV-LSSTSLRLHSNPE------PKTFTFDHVAD 77
           ++++V VR RP   +  +A  ++ + + V L   S++   NP+      PKTFTFD V D
Sbjct: 8   ESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVK---NPKGTAHEMPKTFTFDAVYD 64

Query: 78  VDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIP 137
            +  Q  ++    + +V+S + G+NGTIFAYGQTG+GKT+TM G           RGVIP
Sbjct: 65  WNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPE----KRGVIP 120

Query: 138 RSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDS-ASAGLYLREHIKKGVF 196
            SF+++F+ I R + +      +L + S++EIY E+I DLL    +  L L+E    GV+
Sbjct: 121 NSFDHIFTHISRSQNQ-----QYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVY 175

Query: 197 VVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNEIVN- 255
           V      V  S  E   V++ G +NR V +T+MN  SSRSHA+F ITIE  E   +  N 
Sbjct: 176 VKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENH 235

Query: 256 IRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCY 315
           IR   LNLVDLAGSERQ  T A+G RLKEA  IN SLS LG VI+ALVD   GK  H+ Y
Sbjct: 236 IRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVD---GKSTHIPY 292

Query: 316 RDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQ- 374
           RDSKLT LL+DSLGGNAKT ++ANV P S    ETL+TL +A RAK IKNK  VNED + 
Sbjct: 293 RDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKD 352

Query: 375 GNVSQLQAEVKRLKEQLAELA------------------SGQTPPESFLTRDKKKTNYME 416
             + + Q E+ RLK QL + +                   G+   E     +++  +  +
Sbjct: 353 ALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDD 412

Query: 417 YFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKE 476
           Y++         EQ++K  IEK   +ED +L  E+ ++  K   K  ED  +R EK   E
Sbjct: 413 YWR---------EQQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMED--LRREKDAAE 461

Query: 477 SRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRA 536
             G  +   + +LL   +N +    EQ +          +   + E+ RR R ++  ++ 
Sbjct: 462 MLGAKIKAMESKLLVGGKNIVDHTNEQQK------ILEQKRQEIAEQKRREREIQ--QQM 513

Query: 537 QEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELN 596
           +  D +T+ +L++ +S +         QQ    K +K   LF+  + +KA++  +Q E  
Sbjct: 514 ESRDEETL-ELKETYSSL---------QQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHI 563

Query: 597 NSKQEYEEFK-ELTRKRQLE 615
             +QE E+ + ELTR+ +L+
Sbjct: 564 KERQELEQTQNELTRELKLK 583



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 76/381 (19%), Positives = 149/381 (39%), Gaps = 44/381 (11%)

Query: 932  LKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDS-----DKKVVAD 986
            L +++    E+Q +T    +++ +  K+  SL A   VIS+L   + +     D K+   
Sbjct: 241  LNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRL 300

Query: 987  LMNQIQELRTSVCEKT---------ETIDTLKQELKDINCKYNSALVDREESRVLIKKQE 1037
            L + +     +V             ET+ TL+   +  N K N   V+ +    L+++ +
Sbjct: 301  LQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIK-NKPRVNEDPKDALLREFQ 359

Query: 1038 VDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKE 1097
             +I  LK  L  R +     R+   E                ++     +  +EE   K+
Sbjct: 360  EEIARLKAQLEKRSIGRRKRREKRREGGGSGG--------GGEEEEEEGEEGEEEGDDKD 411

Query: 1098 ALIQELQHKLN-QKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLL 1156
               +E Q KL  +K+  VE        KMR L+   +   ED +  K          K +
Sbjct: 412  DYWREQQEKLEIEKRAIVEDHSLVAEEKMRLLKE-KEKKMEDLRREKDAAEMLGAKIKAM 470

Query: 1157 ET---------------QEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREM 1201
            E+               Q++ +E  R      +    ++ +  E ++ E L +KE     
Sbjct: 471  ESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETY--- 527

Query: 1202 ENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNH-PDNQQLKNEQEESIKERLAKSKIV 1260
             +L+ E     +K   L  +L  +K +  +  + H  + Q+L+  Q E  +E   K  I+
Sbjct: 528  SSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLII 587

Query: 1261 EEMLKMKADLEEVQSALYNKE 1281
            E  + ++   + +  A +++E
Sbjct: 588  ENFIPLEEKSKIMNRAFFDEE 608



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 35/168 (20%), Positives = 81/168 (48%), Gaps = 10/168 (5%)

Query: 847  DNLRLENEKL-LESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMEL 905
            D  R + EKL +E +A ++D     +E M+  + +  + +++ ++E +          E+
Sbjct: 412  DYWREQQEKLEIEKRAIVEDHSLVAEEKMRL-LKEKEKKMEDLRREKDAA--------EM 462

Query: 906  LEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLA 965
            L A+ +      L   ++  + + E  K+LE  RQE  ++  +  +   +++  +E  L 
Sbjct: 463  LGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLE 522

Query: 966  TEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELK 1013
             ++  SSL++  D   K +  L +++Q ++  + +  E     +QEL+
Sbjct: 523  LKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELE 570



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 53/278 (19%), Positives = 120/278 (43%), Gaps = 28/278 (10%)

Query: 705 PEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSE 764
           P +NE   +A+   LR  QE+++ L+A+L++      K ++          + +E   S 
Sbjct: 344 PRVNEDPKDAL---LREFQEEIARLKAQLEKRSIGRRKRRE----------KRREGGGSG 390

Query: 765 RIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSF 824
                +++E         E+  +E   K+D+ + +   L +   +  ++ S V  E    
Sbjct: 391 GGGEEEEEEG--------EEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRL 442

Query: 825 KTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRN 884
              +EK+   L       ++    ++    KLL     + D  +  Q+I++ +  +++  
Sbjct: 443 LKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQ 502

Query: 885 LQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQK 944
            +  ++  + ++S     +EL E       ++ ++ ++ K+  SK  L+ ++A   + Q+
Sbjct: 503 KRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSK--LQAVKAEIHDLQE 560

Query: 945 ETAKCEQQMAKVQ-----KLEESLLATEKVISSLEKSR 977
           E  K  Q++ + Q     +L+   L  E  I   EKS+
Sbjct: 561 EHIKERQELEQTQNELTRELKLKHLIIENFIPLEEKSK 598



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 41/196 (20%), Positives = 90/196 (45%), Gaps = 32/196 (16%)

Query: 1157 ETQEQEIEDG-----------RASKTSLEHLVTKLNEDREVKNAEILRM-KEQLREMENL 1204
            E +E+E E+G           R  +  LE     + ED  +   E +R+ KE+ ++ME+L
Sbjct: 394  EEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDL 453

Query: 1205 RLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEML 1264
            R E     +   +L  ++  ++ +     +N  D+    NEQ++ ++++       +E+ 
Sbjct: 454  RREK----DAAEMLGAKIKAMESKLLVGGKNIVDHT---NEQQKILEQKR------QEIA 500

Query: 1265 KMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLE-------EMYE 1317
            + K    E+Q  + +++ E L + +     Q       ++ ++L SKL+       ++ E
Sbjct: 501  EQKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQE 560

Query: 1318 ERERTSQEMEMLRKQV 1333
            E  +  QE+E  + ++
Sbjct: 561  EHIKERQELEQTQNEL 576


>gi|170784809 kinesin family member 17 isoform b [Homo sapiens]
          Length = 1028

 Score =  291 bits (744), Expect = 4e-78
 Identities = 192/466 (41%), Positives = 261/466 (56%), Gaps = 62/466 (13%)

Query: 25  DAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLH---SNP-----EPKTFTFDHVA 76
           +A+KV VR RP  +R       +  C  V++    R      NP      PK FTFD   
Sbjct: 4   EAVKVVVRCRPMNQRE-----RELRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDGAY 58

Query: 77  DVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVI 136
            VD   E ++  +A  +VE    GYNGTIFAYGQTGSGK+FTM G  +  +     RG+I
Sbjct: 59  HVDHVTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPS----QRGII 114

Query: 137 PRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDS-ASAGLYLREHIKKGV 195
           PR+FE++F     E  +      FL + S++EIYNE + DLL +     L L+EH +KGV
Sbjct: 115 PRAFEHVF-----ESVQCAENTKFLVRASYLEIYNEDVRDLLGADTKQKLELKEHPEKGV 169

Query: 196 FVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESM---EKSNE 252
           +V G     V S A+   ++  GW+NR V  T MN++SSRSH++FTI+IE     E+  +
Sbjct: 170 YVKGLSMHTVHSVAQCEHIMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKD 229

Query: 253 IVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRH 312
             ++R   LNLVDLAGSERQ  T A G RLKEA  IN SLS LG VI+ALVD   G+ +H
Sbjct: 230 --HLRAGKLNLVDLAGSERQSKTGATGERLKEATKINLSLSALGNVISALVD---GRCKH 284

Query: 313 VCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNED 372
           V YRDSKLT LL+DSLGGN KT ++A + P    + ETLSTL +A RAK I+NK  +NED
Sbjct: 285 VPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIRNKPRINED 344

Query: 373 TQ-GNVSQLQAEVKRLK---------EQLAELASGQTPPESFLTRDK------------- 409
            +   + + Q E+K+LK           L+ L S Q PP+     +K             
Sbjct: 345 PKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVPPDPVQVEEKLLPQPVIQHDVEA 404

Query: 410 KKTNYMEYFQEAMLFFK---KSEQEKKSLIEKVTQLEDLTLKKEKF 452
           +K    E ++E +   K   K+EQE ++ +E     ED+T  +  +
Sbjct: 405 EKQLIREEYEERLARLKADYKAEQESRARLE-----EDITAMRNSY 445



 Score = 33.5 bits (75), Expect = 1.5
 Identities = 48/246 (19%), Positives = 101/246 (41%), Gaps = 26/246 (10%)

Query: 915  KLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLE 974
            ++S   E  K++     L +++    E+Q +T    +++ +  K+  SL A   VIS+L 
Sbjct: 219  EMSAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGERLKEATKINLSLSALGNVISALV 278

Query: 975  KSRDS-----DKKVVADLMN---------QIQELRTSVCEKTETIDTLKQELKDINCKYN 1020
              R       D K+   L +          +  L  +     ET+ TL+   +  N + N
Sbjct: 279  DGRCKHVPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIR-N 337

Query: 1021 SALVDREESRVLIKKQEVDILDLKETLRLR--------ILSEDIERD-MLCEDLAHATEQ 1071
               ++ +    L+++ + +I  LK  L  +        +LS  +  D +  E+       
Sbjct: 338  KPRINEDPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVPPDPVQVEEKLLPQPV 397

Query: 1072 LNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHV 1131
            +    EA K+   + +  +E L + +A  +  Q    + +E++   +N Y+ ++  LE  
Sbjct: 398  IQHDVEAEKQL--IREEYEERLARLKADYKAEQESRARLEEDITAMRNSYDVRLSTLEEN 455

Query: 1132 MDSAAE 1137
            +    E
Sbjct: 456  LRKETE 461


>gi|170784807 kinesin family member 17 isoform a [Homo sapiens]
          Length = 1029

 Score =  291 bits (744), Expect = 4e-78
 Identities = 192/466 (41%), Positives = 261/466 (56%), Gaps = 62/466 (13%)

Query: 25  DAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLH---SNP-----EPKTFTFDHVA 76
           +A+KV VR RP  +R       +  C  V++    R      NP      PK FTFD   
Sbjct: 4   EAVKVVVRCRPMNQRE-----RELRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDGAY 58

Query: 77  DVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVI 136
            VD   E ++  +A  +VE    GYNGTIFAYGQTGSGK+FTM G  +  +     RG+I
Sbjct: 59  HVDHVTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPS----QRGII 114

Query: 137 PRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDS-ASAGLYLREHIKKGV 195
           PR+FE++F     E  +      FL + S++EIYNE + DLL +     L L+EH +KGV
Sbjct: 115 PRAFEHVF-----ESVQCAENTKFLVRASYLEIYNEDVRDLLGADTKQKLELKEHPEKGV 169

Query: 196 FVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESM---EKSNE 252
           +V G     V S A+   ++  GW+NR V  T MN++SSRSH++FTI+IE     E+  +
Sbjct: 170 YVKGLSMHTVHSVAQCEHIMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKD 229

Query: 253 IVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRH 312
             ++R   LNLVDLAGSERQ  T A G RLKEA  IN SLS LG VI+ALVD   G+ +H
Sbjct: 230 --HLRAGKLNLVDLAGSERQSKTGATGERLKEATKINLSLSALGNVISALVD---GRCKH 284

Query: 313 VCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNED 372
           V YRDSKLT LL+DSLGGN KT ++A + P    + ETLSTL +A RAK I+NK  +NED
Sbjct: 285 VPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIRNKPRINED 344

Query: 373 TQ-GNVSQLQAEVKRLK---------EQLAELASGQTPPESFLTRDK------------- 409
            +   + + Q E+K+LK           L+ L S Q PP+     +K             
Sbjct: 345 PKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVPPDPVQVEEKLLPQPVIQHDVEA 404

Query: 410 KKTNYMEYFQEAMLFFK---KSEQEKKSLIEKVTQLEDLTLKKEKF 452
           +K    E ++E +   K   K+EQE ++ +E     ED+T  +  +
Sbjct: 405 EKQLIREEYEERLARLKADYKAEQESRARLE-----EDITAMRNSY 445



 Score = 33.5 bits (75), Expect = 1.5
 Identities = 48/246 (19%), Positives = 101/246 (41%), Gaps = 26/246 (10%)

Query: 915  KLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLE 974
            ++S   E  K++     L +++    E+Q +T    +++ +  K+  SL A   VIS+L 
Sbjct: 219  EMSAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGERLKEATKINLSLSALGNVISALV 278

Query: 975  KSRDS-----DKKVVADLMN---------QIQELRTSVCEKTETIDTLKQELKDINCKYN 1020
              R       D K+   L +          +  L  +     ET+ TL+   +  N + N
Sbjct: 279  DGRCKHVPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIR-N 337

Query: 1021 SALVDREESRVLIKKQEVDILDLKETLRLR--------ILSEDIERD-MLCEDLAHATEQ 1071
               ++ +    L+++ + +I  LK  L  +        +LS  +  D +  E+       
Sbjct: 338  KPRINEDPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVPPDPVQVEEKLLPQPV 397

Query: 1072 LNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHV 1131
            +    EA K+   + +  +E L + +A  +  Q    + +E++   +N Y+ ++  LE  
Sbjct: 398  IQHDVEAEKQL--IREEYEERLARLKADYKAEQESRARLEEDITAMRNSYDVRLSTLEEN 455

Query: 1132 MDSAAE 1137
            +    E
Sbjct: 456  LRKETE 461


>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
          Length = 1317

 Score =  285 bits (729), Expect = 2e-76
 Identities = 319/1198 (26%), Positives = 527/1198 (43%), Gaps = 176/1198 (14%)

Query: 26   AIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLH---------SNPEPKTFTFD--- 73
            ++KV VR+RP   R    + +  + +    +T   L               KTFT+D   
Sbjct: 3    SVKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDFSF 62

Query: 74   HVADVDT----TQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFS 129
            + AD  +    +QE VF T+   +V+S   GYN  +FAYGQTGSGK++TMMG S      
Sbjct: 63   YSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDS--- 119

Query: 130  HNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLL---DSASAGLY 186
                G+IPR  E LFS I+       A  SF  + S++EIYNE++ DLL    S +  L 
Sbjct: 120  ----GLIPRICEGLFSRINETTRWDEA--SFRTEVSYLEIYNERVRDLLRRKSSKTFNLR 173

Query: 187  LREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIES 246
            +REH K+G +V    + +V +  +  +++  G  NR  A+T MN  SSRSHA+FTI    
Sbjct: 174  VREHPKEGPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQ 233

Query: 247  MEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVG 306
             +  +E+     S ++LVDLAGSER   T A G+RLKE GNIN+SL  LG VI+AL D+ 
Sbjct: 234  AKFDSEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLS 293

Query: 307  NG--------KQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQ 358
                      KQ  V YRDS LT+LL+DSLGGN+KT +IA + P    +GETLSTL +A 
Sbjct: 294  QDAANTLAKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVNYGETLSTLRYAN 353

Query: 359  RAKLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYF 418
            RAK I NK  +NED         A VK ++E  AE+A             + KT   +  
Sbjct: 354  RAKNIINKPTINED---------ANVKLIRELRAEIA-------------RLKTLLAQGN 391

Query: 419  QEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEK---LHK 475
            Q A+L    +   ++ L +   ++++LT          +   K+ E Q I  E+   L K
Sbjct: 392  QIALLDSPTALSMEEKLQQNEARVQELT---------KEWTNKWNETQNILKEQTLALRK 442

Query: 476  ESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKR 535
            E  G  L  E   L+  + +++ +    + H      Y   + +  E++  L  L+    
Sbjct: 443  EGIGVVLDSELPHLIG-IDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESE 501

Query: 536  AQEMD----AQTIAKLEKAFSEISGM---EKSDKNQQGFSPKAQKEPCLFANT------- 581
                +      T+  L  +   ++G+   E +  NQ       +     F +        
Sbjct: 502  HCIFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLR 561

Query: 582  EKLKAQLLQI----QTELNNSKQE------YEEFKELTRKRQLELESELQSLQKANLNLE 631
            EK K+ LL       T+L+ S++       Y    E  R+++ ELE +L+S +K      
Sbjct: 562  EKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFERQQREELE-KLESKRK------ 614

Query: 632  NLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNS 691
             L+E  +  ++ + ++L ++  E ++     T+  QL  R   + S +  SF        
Sbjct: 615  -LIEEMEEKQKSDKAELERMQQE-VETQRKETEIVQLQIRKQEE-SLKRRSFHIENKLKD 671

Query: 692  SILDNDILNEPVPPEMNEQAFEAISEELRT---VQEQMSALQAKLDEEEHKNLKLQQHVD 748
             + + +   E    E  E   +   +E  T   VQE++  L+   + E+ +  ++ Q +D
Sbjct: 672  LLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELD 731

Query: 749  KLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLK--------SEV 800
            +L+    +       E+    +Q++E +  +  LE+QL+E Q     L+         E 
Sbjct: 732  QLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEEEK 791

Query: 801  HDLRVVLHSA-------------DKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLD 847
             DL  +  S               +EL   +L +  FK  Q  +   L +  +  +  L 
Sbjct: 792  RDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILK 851

Query: 848  NLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKK----------ENETLKS 897
                E +++LE   C  D    L E     +  ++   Q+F+K          +   L+ 
Sbjct: 852  KEVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQY 911

Query: 898  DLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQ 957
             L N +  L  EK+R  ++  +     +N+  ++ K +E    EK+++ A+ +    ++Q
Sbjct: 912  LLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEME----EKEEQLAQYQANANQLQ 967

Query: 958  KLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINC 1017
            KL+ +   T  +    EK R  +K+++     Q +E       + E              
Sbjct: 968  KLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLE-------------- 1013

Query: 1018 KYNSALVDREESRVLIKKQEVDILDLKETLR--------LRILSEDIERDMLCEDLAHAT 1069
            + +SAL       + I++Q   +  L    R        L    E +E+D   E L +  
Sbjct: 1014 RRHSALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKDQ--ERLEYEI 1071

Query: 1070 EQLNM----LTEASKKHSGLLQ-----SAQEELTKKEALIQELQHKLNQKKEEVEQKK 1118
            +QL      +    K H G L+     S+     +K  L+  +  ++N   EE  Q++
Sbjct: 1072 QQLKQKIYEVDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRR 1129



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 99/555 (17%), Positives = 240/555 (43%), Gaps = 69/555 (12%)

Query: 794  DFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLEN 853
            D  KS  +   V+L++   E    + E      ++ K   ++ E+    + +L+ ++ E 
Sbjct: 578  DLSKSRENLSAVMLYNPGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEV 637

Query: 854  EKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERN 913
            E   +    +Q      +E +K     +   L++   E E  + +     + +E +K+R 
Sbjct: 638  ETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQ 697

Query: 914  NKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQK-LEESLLATEKVISS 972
                   EE+     +E L+ L+ +   ++ E  +  Q++ ++QK  +E     E     
Sbjct: 698  -------EEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKR 750

Query: 973  LEKSRDSDKKVVADLMNQIQELRTSV----CEKTETIDTLKQELKDIN---CKYNSALVD 1025
            LE+       +VA L  Q++E +  +      + + ++  K++L+ I     +   A   
Sbjct: 751  LEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAG 810

Query: 1026 REESRVLIKKQEVDILDLK--ETLRLRILSEDI--ERDMLCEDLAHATEQLNMLTEASKK 1081
             +E    ++K ++   + K  + ++L  L +D+  ++D+L +++    E L  L     K
Sbjct: 811  GDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILECLKCEHDK 870

Query: 1082 HSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQS 1141
             S LL+   E +T    + Q+         E+++  +    +K RQL++++         
Sbjct: 871  ESRLLEKHDESVTDVTEVPQDF--------EKIKPVEYRLQYKERQLQYLL--------- 913

Query: 1142 PKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREM 1201
                   Q HL  LLE +++  E       SL++ + ++ ++ E K  ++ + +    ++
Sbjct: 914  -------QNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQL 966

Query: 1202 ENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVE 1261
            + L+   +              +I RQ+E          +++ +++E ++ R  + +  E
Sbjct: 967  QKLQATFEFTA-----------NIARQEE----------KVRKKEKEILESREKQQR--E 1003

Query: 1262 EMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQE---KEQLRSKLEEMYEE 1318
             + +  A LE   SAL       + + ++ ++  +L S + ++   +  L ++ E + ++
Sbjct: 1004 ALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKD 1063

Query: 1319 RERTSQEMEMLRKQV 1333
            +ER   E++ L++++
Sbjct: 1064 QERLEYEIQQLKQKI 1078



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 144/707 (20%), Positives = 293/707 (41%), Gaps = 127/707 (17%)

Query: 400  PPESFLTRDKKKTNYMEYFQEAMLFFKKS----------------EQEKKSLIEKVTQLE 443
            P E+   R+K+K+  +  F  +M    KS                E++++  +EK+    
Sbjct: 554  PKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFERQQREELEKLESKR 613

Query: 444  DLTLKKEKFIQSNK---------MIVKFREDQIIRLEKLHKES---RGGFLPEEQ--DRL 489
             L  + E+  +S+K         +  + +E +I++L+   +E    R  F  E +  D L
Sbjct: 614  KLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLL 673

Query: 490  LSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEK 549
              + + E + LREQ E   +  +        +EE   LR+ E ++R +E++    A+  +
Sbjct: 674  AEKEKFEEERLREQQEIELQKKR--------QEEETFLRVQEELQRLKELNNNEKAEKFQ 725

Query: 550  AFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFKELT 609
             F E+  ++K +K++Q    + +K+       E+ + + + +   L    +E +E  +L 
Sbjct: 726  IFQELDQLQK-EKDEQYAKLELEKK-----RLEEQEKEQVMLVAHLEEQLREKQEMIQLL 779

Query: 610  RKRQLE-LESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQL 668
            R+ +++ +E E + L+    +L  + EA +A   ++  +L K             + ++ 
Sbjct: 780  RRGEVQWVEEEKRDLEGIRESLLRVKEA-RAGGDEDGEELEK----------AQLRFFEF 828

Query: 669  HSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSA 728
              R + KL         +  +   +   DIL + V  E      + I E L+   ++ S 
Sbjct: 829  KRRQLVKL---------VNLEKDLVQQKDILKKEVQEE------QEILECLKCEHDKESR 873

Query: 729  LQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQE 788
            L  K DE      ++ Q  +K++             R+ + ++Q + L Q N L   L+E
Sbjct: 874  LLEKHDESVTDVTEVPQDFEKIKP---------VEYRLQYKERQLQYLLQ-NHLPTLLEE 923

Query: 789  TQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFK--TNQEKEFNKLSERHMHVQLQL 846
             Q   + L      L   L+  +KE+   + + + ++   NQ ++     E   ++  Q 
Sbjct: 924  KQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQLQKLQATFEFTANIARQE 983

Query: 847  DNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELL 906
            + +R + +++LES+              K + + L R L   ++ +  L+      ME+ 
Sbjct: 984  EKVRKKEKEILESRE-------------KQQREALERALARLERRHSALQRHSTLGMEI- 1029

Query: 907  EAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAK--------VQK 958
               +E+  KL+      +E S  +     E    EK +E  + E Q  K        VQK
Sbjct: 1030 ---EEQRQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQK 1086

Query: 959  LEESLLATEKVISSLEKSRDS-------DKKVVA----DLMNQIQELRTSVCEKTET-ID 1006
                 L  +   SSL  S +        D ++ A    ++  ++Q+L   + E   T  D
Sbjct: 1087 DHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDLHRVISEGCSTSAD 1146

Query: 1007 TLKQELKDINCKYNSALVDR--EESRVLIKKQEVDILDLKETLRLRI 1051
            T+K      N K ++  + R  +  R++ +    +  DLK+ +++ I
Sbjct: 1147 TMKD-----NEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISI 1188



 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 96/514 (18%), Positives = 212/514 (41%), Gaps = 82/514 (15%)

Query: 766  IDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFK 825
            +++ +QQ E L +L    K ++E + K    K+E+  ++  + +  KE   V+L+     
Sbjct: 596  LEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQI---- 651

Query: 826  TNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNL 885
                K+   L  R  H++ +L +L  E EK  E +         L+E  + E+ +  +  
Sbjct: 652  ---RKQEESLKRRSFHIENKLKDLLAEKEKFEEER---------LREQQEIELQKKRQEE 699

Query: 886  QNFKKENETLK--SDLNN---------LMELLEAEKERNN---KLSLQFEEDKENSSKEI 931
            + F +  E L+   +LNN           EL + +KE++    KL L+ +  +E   +++
Sbjct: 700  ETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQV 759

Query: 932  LKV--LEAVRQEKQK--------ETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDK 981
            + V  LE   +EKQ+        E    E++   ++ + ESLL  ++  +  ++  +  +
Sbjct: 760  MLVAHLEEQLREKQEMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELE 819

Query: 982  KVVADLMN----QIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQE 1037
            K           Q+ +L     +  +  D LK+E+++          + ++   L++K +
Sbjct: 820  KAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILECLKCEHDKESRLLEKHD 879

Query: 1038 VDILDLKET---------LRLRILSEDIERDMLCED-----LAHATEQLNMLTEASKKHS 1083
              + D+ E          +  R+  ++ +   L ++     L        +L        
Sbjct: 880  ESVTDVTEVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLD 939

Query: 1084 GLLQSAQEELTKKEALIQELQHKLNQ----------------KKEEVEQKKNEY-NFKMR 1126
              L   ++E+ +KE  + + Q   NQ                ++E+V +K+ E    + +
Sbjct: 940  NTLYQVEKEMEEKEEQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREK 999

Query: 1127 QLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEI-------EDGRASKTSLEHLVTK 1179
            Q    ++ A    +   +     + L   +E Q Q++        +    + SLE     
Sbjct: 1000 QQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEA 1059

Query: 1180 LNEDREVKNAEILRMKEQLREMENLRLESQQLIE 1213
            L +D+E    EI ++K+++ E++ ++ +    +E
Sbjct: 1060 LEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTLE 1093



 Score = 60.8 bits (146), Expect = 9e-09
 Identities = 145/739 (19%), Positives = 291/739 (39%), Gaps = 89/739 (12%)

Query: 673  VPKLSPEMGSFG-SLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQA 731
            +  +SP   ++G +L T   +    +I+N+P    +NE A   +  ELR    ++  L A
Sbjct: 332  IATISPADVNYGETLSTLRYANRAKNIINKPT---INEDANVKLIRELRAEIARLKTLLA 388

Query: 732  KLDE----EEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQ 787
            + ++    +    L +++   KL+ +  ++QEL       W + Q  L  Q   L K+  
Sbjct: 389  QGNQIALLDSPTALSMEE---KLQQNEARVQELTKEWTNKWNETQNILKEQTLALRKE-- 443

Query: 788  ETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLD 847
                    L SE+  L  +    D +L S  +     K  Q   +    +      + L 
Sbjct: 444  ---GIGVVLDSELPHLIGI----DDDLLSTGIILYHLKEGQT--YVGRDDASTEQDIVLH 494

Query: 848  NLRLENEKLLESKAC-------LQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLN 900
             L LE+E  +            L  S  ++  +   E   L++            +   N
Sbjct: 495  GLDLESEHCIFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFR--FN 552

Query: 901  NLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLE 960
            +  E  +  ++R + L   F     + SK    +   +      E  +  QQ  +++KLE
Sbjct: 553  HPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFER--QQREELEKLE 610

Query: 961  ESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYN 1020
                   K+I  +E+ + SDK   A+L    QE+ T    K   I  L+   ++ + K  
Sbjct: 611  SK----RKLIEEMEEKQKSDK---AELERMQQEVETQ--RKETEIVQLQIRKQEESLKRR 661

Query: 1021 SALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASK 1080
            S  ++ +   +L +K++ +   L+E   + +  +  E     E      E+L  L E + 
Sbjct: 662  SFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQEE----ETFLRVQEELQRLKELNN 717

Query: 1081 KHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQ 1140
                      +EL + +    E   KL  +K+ +E+++ E    +  LE  +    E  Q
Sbjct: 718  NEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQ 777

Query: 1141 SPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLRE 1200
              +          + +E +++++E  R S   ++      +ED E         K QLR 
Sbjct: 778  LLRRGE------VQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELE------KAQLRF 825

Query: 1201 MENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIV 1260
             E  R +  +L+     L  Q D +K++ +  +Q   +  + ++++E  + E+  +S  V
Sbjct: 826  FEFKRRQLVKLVNLEKDLVQQKDILKKEVQE-EQEILECLKCEHDKESRLLEKHDES--V 882

Query: 1261 EEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERE 1320
             ++ ++  D E+++   Y                  L+ K  Q +  L++ L  + EE++
Sbjct: 883  TDVTEVPQDFEKIKPVEYR-----------------LQYKERQLQYLLQNHLPTLLEEKQ 925

Query: 1321 RTSQEME-----------MLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEE 1369
            R  + ++            + K++E   E+  +   + N  QK+Q          R  E+
Sbjct: 926  RAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQLQKLQATFEFTANIARQEEK 985

Query: 1370 TEKLRAENVFLKEKKRSES 1388
              K   E +  +EK++ E+
Sbjct: 986  VRKKEKEILESREKQQREA 1004


>gi|41352705 kinesin family member 3C [Homo sapiens]
          Length = 793

 Score =  284 bits (727), Expect = 4e-76
 Identities = 238/747 (31%), Positives = 367/747 (49%), Gaps = 76/747 (10%)

Query: 25  DAIKVFVRIRPPAERSGSADGEQNLCLSV-LSSTSLRLHSNPE------PKTFTFDHVAD 77
           +A+KV  R RP + +  +A  EQ L + V L   +LR   NP       PKTFTFD V D
Sbjct: 9   EALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLR---NPRAAPGELPKTFTFDAVYD 65

Query: 78  VDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIP 137
             + Q  ++    + +++S + G+NGT+FAYGQTG+GKT+TM G          LRGVIP
Sbjct: 66  ASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPE----LRGVIP 121

Query: 138 RSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAG-LYLREHIKKGVF 196
            +FE++F+ I R + +      +L + S++EIY E+I DLL       L L+E+ + GV+
Sbjct: 122 NAFEHIFTHISRSQNQ-----QYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVY 176

Query: 197 VVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNEIVN- 255
           +      V  +  E   V++ G + R V ST MN  SSRSHA+F IT+E  E+ ++  + 
Sbjct: 177 IKDLSSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDH 236

Query: 256 IRTSLLNLVDLAGSERQKDTH------------------------AEGMRLKEAGNINRS 291
           IR   LNLVDLAGSERQ                            A G R KEA  IN S
Sbjct: 237 IRVGKLNLVDLAGSERQNKAGPNTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLS 296

Query: 292 LSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETL 351
           LS LG VI AL   GN +  H+ YRDSKLT LL+DSLGGNAKT ++A + P S  + E+L
Sbjct: 297 LSALGNVIAALA--GN-RSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESL 353

Query: 352 STLNFAQRAKLIKNKAVVNEDTQGN-VSQLQAEVKRLKEQLAELASGQTPPESFLTRDKK 410
           STL FA RAK IKNK  VNED +   + + Q E+ RLK QL +       P    +R KK
Sbjct: 354 STLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRKSSRRKK 413

Query: 411 KTNYMEYFQEAML---FFKKSEQEKKSLIEKVTQLEDLTLKK--EKFIQSNKMIVKFRED 465
             +    + E  +   +  + E +  +       + +  L+K  E ++Q  K  ++  + 
Sbjct: 414 AVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILESALEKNMENYLQEQKERLEEEKA 473

Query: 466 QIIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLR------EQIEHHPRVAKYAMENHS 519
            I     L  E +   L EE++++L +LR E Q         + +E    +    + +H+
Sbjct: 474 AIQDDRSLVSEEKQKLL-EEKEKMLEDLRREQQATELLAAKYKAMESKLLIGGRNIMDHT 532

Query: 520 LRE----ENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEP 575
             +    E +R  + E  +R +EM  + + + E+   E+ G   S   QQ    K +K  
Sbjct: 533 NEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETM-ELRGTYTS--LQQEVEVKTKKLK 589

Query: 576 CLFANTEKLKAQLLQIQTELNNSKQEYEEFK-ELTRKRQLE---LESELQSLQKANLNLE 631
            L+A  + +KA++     E    +Q+ EE + E TR+ +L+   +E+ +   +K  +   
Sbjct: 590 KLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNR 649

Query: 632 NLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNS 691
             L+  +   + +      + +  +K   T    Y+       +++  MGS      +N 
Sbjct: 650 LFLDCEEEQWKFQPLVPAGVSSSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENI 709

Query: 692 SILDNDILNEPVPPEMNEQAFEAISEE 718
             L+ D+     PP + E  F    E+
Sbjct: 710 MFLELDV----SPPAVFEMEFSHDQEQ 732



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 32/167 (19%), Positives = 83/167 (49%), Gaps = 10/167 (5%)

Query: 849  LRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEA 908
            L+ + E+L E KA +QD    + E  +  +++  + L++ ++E +          ELL A
Sbjct: 461  LQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQA--------TELLAA 512

Query: 909  E-KERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATE 967
            + K   +KL +      ++++++  K+LE  RQE  ++  +  +   ++   +E  +   
Sbjct: 513  KYKAMESKLLIGGRNIMDHTNEQ-QKMLELKRQEIAEQKRREREMQQEMMLRDEETMELR 571

Query: 968  KVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKD 1014
               +SL++  +   K +  L  ++Q ++  + ++ +    ++Q+L++
Sbjct: 572  GTYTSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEE 618



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 55/291 (18%), Positives = 119/291 (40%), Gaps = 30/291 (10%)

Query: 866  SYDNLQEIMKFEIDQLSRNLQNFKKENE----TLKSDLNNLMELLEAEKERNNKLSLQFE 921
            SYD     ++F     ++N++N  + NE    TL  +    +  L+A+ E+   L  +  
Sbjct: 348  SYDESLSTLRFA--NRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPR 405

Query: 922  EDKENSSKEILK--------VLEAVRQEKQKETAKCEQQMAKVQKLEESLLAT--EKVIS 971
                   K +          V+EA   E++ +           Q + ES L    E  + 
Sbjct: 406  RKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDN---NNNHRPPQPILESALEKNMENYLQ 462

Query: 972  SLEKSRDSDKKVVADLMNQIQELRTSVCEKTET-IDTLKQELKD---INCKYNSALVDRE 1027
              ++  + +K  + D  + + E +  + E+ E  ++ L++E +    +  KY +      
Sbjct: 463  EQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAM----- 517

Query: 1028 ESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQ 1087
            ES++LI  + +     ++   L +  ++I      E      +++ +  E + +  G   
Sbjct: 518  ESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRRE--REMQQEMMLRDEETMELRGTYT 575

Query: 1088 SAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAED 1138
            S Q+E+  K   +++L  KL   K E++ + +EY    + LE   +    +
Sbjct: 576  SLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRE 626



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 25/105 (23%), Positives = 54/105 (51%), Gaps = 5/105 (4%)

Query: 1286 RMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVG 1345
            R+ +E    Q   S   +EK++L  + E+M E+  R  Q  E+L  + +  A E+  L+G
Sbjct: 467  RLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYK--AMESKLLIG 524

Query: 1346 HQNL---HQKIQYVVRLKKENVRLAEETEKLRAENVFLKEKKRSE 1387
             +N+     + Q ++ LK++ +   +  E+   + + L++++  E
Sbjct: 525  GRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETME 569



 Score = 35.8 bits (81), Expect = 0.29
 Identities = 43/214 (20%), Positives = 99/214 (46%), Gaps = 37/214 (17%)

Query: 1096 KEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKL 1155
            + AL + +++ L ++KE +E++K               +A +D +S  +         KL
Sbjct: 450  ESALEKNMENYLQEQKERLEEEK---------------AAIQDDRSLVSEEK-----QKL 489

Query: 1156 LETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKN 1215
            LE +E+ +ED R  + + E L  K     +   +++L     + +  N   E Q+++E  
Sbjct: 490  LEEKEKMLEDLRREQQATELLAAKY----KAMESKLLIGGRNIMDHTN---EQQKMLE-- 540

Query: 1216 WLLQGQLDDIKRQKENSDQ----NHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLE 1271
             L + ++ + KR++    Q       +  +L+       +E   K+K   ++ K+ A L+
Sbjct: 541  -LKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQEVEVKTK---KLKKLYAKLQ 596

Query: 1272 EVQSALYNKEMECLRMTDEVERTQTLESKAFQEK 1305
             V++ + ++  E +R+  ++E  Q  +++  + K
Sbjct: 597  AVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLK 630



 Score = 35.0 bits (79), Expect = 0.50
 Identities = 43/211 (20%), Positives = 91/211 (43%), Gaps = 27/211 (12%)

Query: 1067 HATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMR 1126
            H   Q  + +   K     LQ  +E L +++A IQ+ +  ++++K+++ ++K +    +R
Sbjct: 442  HRPPQPILESALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLR 501

Query: 1127 QLEHVMDSAAEDPQSPKTP-----PHFQTHL---AKLLETQEQEIEDGRASKTSLEHLVT 1178
            + +   +  A   ++ ++       +   H     K+LE + QEI + +           
Sbjct: 502  REQQATELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQK----------- 550

Query: 1179 KLNEDREVKNAEILRMKEQLREMENLRLESQQLIE----KNWLLQGQLDDIKRQ-KENSD 1233
                +RE++   +LR  E+  E+       QQ +E    K   L  +L  +K + ++  D
Sbjct: 551  --RREREMQQEMMLR-DEETMELRGTYTSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHD 607

Query: 1234 QNHPDNQQLKNEQEESIKERLAKSKIVEEML 1264
            +     Q L+  Q E  +E   K  I+E  +
Sbjct: 608  EYIRVRQDLEEAQNEQTRELKLKYLIIENFI 638



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 43/179 (24%), Positives = 78/179 (43%), Gaps = 17/179 (9%)

Query: 1209 QQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKA 1268
            +  +EKN  ++  L + K + E       D++ L +E+++ + E   K K++E+ L+ + 
Sbjct: 450  ESALEKN--MENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEE--KEKMLED-LRREQ 504

Query: 1269 DLEEVQSALYNKEMECLR-------MTDEVERTQTLESKAFQEKEQLRSKLEEMYEERER 1321
               E+ +A Y K ME          M    E+ + LE K  +  EQ R + E   E   R
Sbjct: 505  QATELLAAKY-KAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLR 563

Query: 1322 TSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVR----LKKENVRLAEETEKLRAE 1376
              + ME+         E   K    + L+ K+Q V         E +R+ ++ E+ + E
Sbjct: 564  DEETMELRGTYTSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNE 622


>gi|4758650 kinesin family member 5C [Homo sapiens]
          Length = 957

 Score =  274 bits (700), Expect = 5e-73
 Identities = 267/936 (28%), Positives = 436/936 (46%), Gaps = 111/936 (11%)

Query: 68  KTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDN 127
           K + FD V   +TTQE V+   AK IV+  + GYNGTIFAYGQT SGKT TM G      
Sbjct: 45  KPYVFDRVLPPNTTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDP- 103

Query: 128 FSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAGLYL 187
               L G+IPR    +F  I    E       F  K S+ EIY ++I DLLD +   L +
Sbjct: 104 ---QLMGIIPRIAHDIFDHIYSMDENL----EFHIKVSYFEIYLDKIRDLLDVSKTNLAV 156

Query: 188 REHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESM 247
            E   +  +V G  E+ V+S  E   V+  G  NR VA T+MN  SSRSH++F I I+  
Sbjct: 157 HEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIK-- 214

Query: 248 EKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGN 307
           +++ E     +  L LVDLAGSE+   T AEG  L EA NIN+SLS LG VI+AL +   
Sbjct: 215 QENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE--- 271

Query: 308 GKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKA 367
           G + HV YRDSK+T +L+DSLGGN +T I+    P      ET STL F QRAK IKN  
Sbjct: 272 GTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTV 331

Query: 368 VVN------------EDTQGNVSQLQAEVKRLKEQLAELASGQTPP--ESFLTRDKKK-- 411
            VN            E  +     L+  ++ L+ +L    +G+  P  E    +D+K   
Sbjct: 332 SVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLE 391

Query: 412 --TNYMEYFQEAMLFFKKSEQEKKSLIEKVTQL-EDLTLKKEKFIQSNKMIVKFREDQII 468
              N       A +    S +EK+   E+++ L   L  K ++  Q +++  K ++  + 
Sbjct: 392 PCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQML- 450

Query: 469 RLEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRR-L 527
                           +QD LL+  R + + ++E++       +  +EN + ++E +  L
Sbjct: 451 ----------------DQDELLASTRRDYEKIQEEL------TRLQIENEAAKDEVKEVL 488

Query: 528 RLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQ 587
           + LE +    +  +Q +             +K+  N+Q     AQK   L       + +
Sbjct: 489 QALEELAVNYDQKSQEVE------------DKTRANEQLTDELAQKTTTLTTT----QRE 532

Query: 588 LLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQ-KANLNLENLLEATKACKRQEVS 646
           L Q+Q   N+ K+   E   L  K   E+   + +   K   ++  ++E      R  +S
Sbjct: 533 LSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYIS 592

Query: 647 QLNKIHAETLKIITTPTKAYQLHS-RPVPKLSPEMGSFGSLYTQNSS---ILDNDILNEP 702
           ++ K   ++L   +   ++ Q+ S R +     E+ +   L +Q+ +    L + + N  
Sbjct: 593 KM-KSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNME 651

Query: 703 VPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVD--------KLEHHS 754
                 E++ +++SEEL  ++ Q    +    ++E ++L   Q  +        ++E H 
Sbjct: 652 QKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHR 711

Query: 755 TQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKEL 814
              Q+  S  R D  +++++++ ++  L ++LQ  Q K   L S+ + L++     ++E+
Sbjct: 712 EAHQKQLSRLR-DEIEEKQKIIDEIRDLNQKLQLEQEK---LSSDYNKLKI--EDQEREM 765

Query: 815 SSVKLEYSSFKTNQEKEFNKLSERHMHVQLQ-LDNLRLENEKLLESKACLQDSYDN---- 869
              KL   + K  Q +E  K  E  +  +LQ L NLR    + L ++       DN    
Sbjct: 766 KLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGG 825

Query: 870 -----LQEIMKFE--IDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEE 922
                 Q+I   E  ++QL++  +   ++N  L+ +L  L + L A  ER   L    +E
Sbjct: 826 GSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKE 885

Query: 923 DKENS-------SKEILKVLEAVRQEKQKETAKCEQ 951
            KEN+        +E+ ++ EAVR +     A   Q
Sbjct: 886 AKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQ 921



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 95/490 (19%), Positives = 206/490 (42%), Gaps = 78/490 (15%)

Query: 716  SEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEEL 775
            +EE     E++S+L  +LD+++ +  +  Q  +KL+       EL +S R D+ K QEEL
Sbjct: 411  TEEKEKYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEEL 470

Query: 776  L----------SQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFK 825
                        ++  + + L+E     D    EV D       A+++L+    + ++  
Sbjct: 471  TRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKT----RANEQLTDELAQKTTTL 526

Query: 826  TNQEKEFNKLSERHMHVQ---LQLDNLRLEN-------------EKLLESKACLQDSYDN 869
            T  ++E ++L E   H +    ++ NL L++             + L +    +++ +  
Sbjct: 527  TTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTM 586

Query: 870  LQ---EIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAE----------------- 909
             +     MK E+    ++L N  K+ E+ + D N  M   E E                 
Sbjct: 587  ARLYISKMKSEV----KSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKS 642

Query: 910  ----KERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLA 965
                 +   +   Q EE +++ S+E+ K+    +  +     K ++ + ++Q  EE   A
Sbjct: 643  LTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKA 702

Query: 966  TEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVD 1025
             E+    +E  R++ +K ++ L ++I+E +  + E  +    L+ E + ++  YN   ++
Sbjct: 703  LEQ---QMESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIE 759

Query: 1026 REESRVLIKK----------QEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNML 1075
             +E  + ++K             D+  L+ET+   + +    R +  +DL    ++   L
Sbjct: 760  DQEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVEL 819

Query: 1076 -------TEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQL 1128
                   + A K+    L++  E+LTK    +      L  +  ++E++      +++ L
Sbjct: 820  DNDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKAL 879

Query: 1129 EHVMDSAAED 1138
            E  +  A E+
Sbjct: 880  ESALKEAKEN 889



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 91/474 (19%), Positives = 203/474 (42%), Gaps = 61/474 (12%)

Query: 888  FKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAV--RQEKQKE 945
            F +  +T+K+ ++  +EL   E ++      + E++K  + K +++ LE    R    + 
Sbjct: 320  FGQRAKTIKNTVSVNLELTAEEWKKK----YEKEKEKNKTLKNVIQHLEMELNRWRNGEA 375

Query: 946  TAKCEQQMAKVQK---------LEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRT 996
              + EQ  AK QK         + +++      IS+ EK +  ++  ++ L  Q+ +   
Sbjct: 376  VPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEE--ISSLYRQLDDKDD 433

Query: 997  SVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLR--LRILSE 1054
             + ++++  + LKQ++ D +    S   D E+ +  + + +++    K+ ++  L+ L E
Sbjct: 434  EINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEE 493

Query: 1055 -DIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEE 1113
              +  D   +++   T     LT+   + +  L + Q EL++    +QEL +   ++  E
Sbjct: 494  LAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQ----LQELSNHQKKRATE 549

Query: 1114 VEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPH---------FQTHLAKLLETQEQEIE 1164
            +       N  ++ L  +      +        +          + +++K+    +  + 
Sbjct: 550  I------LNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVN 603

Query: 1165 DGRASKTSLEHLVTKLN-EDREVKNAEIL------RMKEQLREMENLRLESQQLIEKNWL 1217
              +  +++      K+N  +RE+   ++L      ++K     M+N+  + +QL E    
Sbjct: 604  RSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDS 663

Query: 1218 LQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSAL 1277
            L  +L  ++ Q++  + +  D +          KE L + +  EEM K      E     
Sbjct: 664  LSEELAKLRAQEKMHEVSFQDKE----------KEHLTRLQDAEEMKKALEQQMESHREA 713

Query: 1278 YNKEMECLRMTDEVERTQTL--ESKAFQEKEQL-RSKLEEMYEERERTSQEMEM 1328
            + K++  LR  DE+E  Q +  E +   +K QL + KL   Y + +   QE EM
Sbjct: 714  HQKQLSRLR--DEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREM 765



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 68/383 (17%), Positives = 154/383 (40%), Gaps = 38/383 (9%)

Query: 1000 EKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQE-------VDILDLKETLRLRIL 1052
            EK +T+  + Q L+    ++ +     E+ ++  K Q+         I+D    +   I 
Sbjct: 351  EKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGIS 410

Query: 1053 SEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKE 1112
            +E  E++   E+++    QL+   +   + S L +  ++++  ++ L+   +    + +E
Sbjct: 411  TE--EKEKYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQE 468

Query: 1113 EVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTS 1172
            E+ + + E      +++ V+ +  E              LA   + + QE+ED   +   
Sbjct: 469  ELTRLQIENEAAKDEVKEVLQALEE--------------LAVNYDQKSQEVEDKTRANEQ 514

Query: 1173 LEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENS 1232
            L   + +          E+ +++E     +    E   L+ K+    G +      K  +
Sbjct: 515  LTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLA 574

Query: 1233 DQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVE 1292
            D N          +EE    RL  SK+  E+  +    ++++SA  +   +      E+ 
Sbjct: 575  DVNGVI-------EEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELA 627

Query: 1293 RTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQK 1352
              Q L S       Q  +K++ + +  +   Q+   L +  + L+EE  KL   + +H+ 
Sbjct: 628  ACQLLIS-------QHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHE- 679

Query: 1353 IQYVVRLKKENVRLAEETEKLRA 1375
            + +  + K+   RL +  E  +A
Sbjct: 680  VSFQDKEKEHLTRLQDAEEMKKA 702



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 52/231 (22%), Positives = 104/231 (45%), Gaps = 28/231 (12%)

Query: 1160 EQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLE---SQQLIEKNW 1216
            E+E E  +  K  ++HL  +LN  R   N E +   EQ+   +   LE   +  +I+   
Sbjct: 347  EKEKEKNKTLKNVIQHLEMELNRWR---NGEAVPEDEQISAKDQKNLEPCDNTPIIDNIA 403

Query: 1217 LLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSA 1276
             +   +     +KE  D+      +  +++++ I ++   S++ E++ +   D +E+   
Sbjct: 404  PVVAGIST--EEKEKYDEEISSLYRQLDDKDDEINQQ---SQLAEKLKQQMLDQDEL--- 455

Query: 1277 LYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECL 1336
            L +   +  ++ +E+ R Q     A  E +++   LEE+    ++ SQE+E   +  E L
Sbjct: 456  LASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQL 515

Query: 1337 AEENGKLVGHQNLHQKIQYVVRLKKENVRLAE--ETEKLRAE---NVFLKE 1382
             +E         L QK   +   ++E  +L E    +K RA    N+ LK+
Sbjct: 516  TDE---------LAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKD 557


>gi|83716024 kinesin family member 21B [Homo sapiens]
          Length = 1624

 Score =  271 bits (694), Expect = 2e-72
 Identities = 312/1181 (26%), Positives = 507/1181 (42%), Gaps = 183/1181 (15%)

Query: 21   SNEGDA-IKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPEPKTFTFDHVADVD 79
            + +GD  +KV VRIRP   +    +G  ++C SV       L    + K FT+D V D+D
Sbjct: 2    AGQGDCCVKVAVRIRPQLSKE-KIEG-CHICTSVTPGEPQVLLG--KDKAFTYDFVFDLD 57

Query: 80   TTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRS 139
            T QE +++T    ++E C  GYN T+ AYGQTG+GKT+TM G       S   +G+IPR+
Sbjct: 58   TWQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTM-GTGFDMATSEEEQGIIPRA 116

Query: 140  FEYLFSLIDREKEKAG----AGKSFLCKCSFIEIYNEQIYDLLDSAS--------AGLYL 187
              +LF  I   K +A     AG  F     F+E+YNE+I DL DS          + + +
Sbjct: 117  IAHLFGGIAERKRRAQEQGVAGPEFKVSAQFLELYNEEILDLFDSTRDPDTRHRRSNIKI 176

Query: 188  REHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESM 247
             E    G++  G   +++ S  E  Q L  G  +R  AST MN +SSRSHA+FTI +  M
Sbjct: 177  HEDANGGIYTTGVTSRLIHSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQM 236

Query: 248  EKSNE--IVN-----------------IRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNI 288
                +  +VN                   T+  + VDLAGSER K T A G R KE  +I
Sbjct: 237  RMCTQPDLVNEAVTGLPDGTPPSSEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISI 296

Query: 289  NRSLSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFG 348
            N  L  LG VI+AL D    K  HV YRDSKLT LL+DSLGGN++T +IA V P  R F 
Sbjct: 297  NCGLLALGNVISALGDQSK-KVVHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFM 355

Query: 349  ETLSTLNFAQRAKLIKNKAVVNED-TQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTR 407
            ETL+TL +A RA+ IKNK VVN+D T   +S L+AE+ RL+ +L E  +G+      +  
Sbjct: 356  ETLNTLKYANRARNIKNKVVVNQDKTSQQISALRAEIARLQMELMEYKAGKR-----VIG 410

Query: 408  DKKKTNYMEYFQEAMLFFK---------KSEQEKKSLI-EKVTQL--EDLTLKKEKFIQS 455
            +     Y + F+E  +  K         K+ QE    I  +VTQL  ++  L   K    
Sbjct: 411  EDGAEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINNRVTQLMSQEANLLLAKAGDG 470

Query: 456  NKMIVKFREDQIIRLEKLHKE---------------SRG--------GFLP--------- 483
            N+ I    ++ I  +E+L  +               SR         G  P         
Sbjct: 471  NEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSRASARSPYSLGASPAAPAFGGSP 530

Query: 484  ----EEQDRLLSELRNEIQTLRE----------QIEHHPRVAKYAMENHSLREENRRLRL 529
                E+   ++   + +++ L++          + E   + AK   EN    +EN     
Sbjct: 531  ASSMEDASEVIRRAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQQENSEETDEN----- 585

Query: 530  LEPVKRAQEMDAQTIAKLE--KAFSEISGMEKS--------DKNQQGFSPKAQKEPCLFA 579
             E  +  +E D     + E  +   E SG E+S        ++ +  F        C   
Sbjct: 586  -EAEEEEEERDESGCEEEEGREDEDEDSGSEESLVDSDSDPEEKEVNFQADLADLTCEIE 644

Query: 580  NTEKLKAQLLQIQTELNNSKQEYEE----FKELTRKRQLELESELQSLQKANLNLENLLE 635
              +KL  +L   Q  L   K +YEE     +   R  QLE +  LQ+L            
Sbjct: 645  IKQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLERDRVLQNL------------ 692

Query: 636  ATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILD 695
            +T  C  +E  + NKI A+         K  +  +R + KL         L  +N S  +
Sbjct: 693  STMECYTEE--KANKIKADY-------EKRLREMNRDLQKLQAAQKEHARL-LKNQSRYE 742

Query: 696  NDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHST 755
             ++          ++A  A+ +++R  Q++   ++ K +  E   LK +Q   + +  + 
Sbjct: 743  RELKKLQAEVAEMKKAKVALMKQMREEQQRRRLVETKRN-REIAQLKKEQRRQEFQIRAL 801

Query: 756  QMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHD--LRVVLHSADKE 813
            + Q+    E +   K QE  +S L  L K + E       LK  + D    V   +   E
Sbjct: 802  ESQKR-QQEMVLRRKTQE--VSALRRLAKPMSERVAGRAGLKPPMLDSGAEVSASTTSSE 858

Query: 814  LSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEI 873
              S     SS      ++ N     H    +   N      K  + K   Q    +  + 
Sbjct: 859  AESGARSVSSIVRQWNRKINHFLGDHPAPTV---NGTRPARKKFQKKGASQ----SFSKA 911

Query: 874  MKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILK 933
             + +   L R + +   +  T+ +        LEA+ ER  K             +E+  
Sbjct: 912  ARLKWQSLERRIIDIVMQRMTIVN--------LEADMERLIK-----------KREELFL 952

Query: 934  VLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQE 993
            + EA+R+++++  A+  ++   +Q+L E +   E + ++++   D      A ++ Q++E
Sbjct: 953  LQEALRRKRERLQAESPEEEKGLQELAEEI---EVLAANIDYINDGITDCQATIV-QLEE 1008

Query: 994  LRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILS 1053
             +  +     ++      L +     ++ L    +  + + ++E  I  L+  LR   ++
Sbjct: 1009 TKEELDSTDTSVVISSCSLAEARLLLDNFLKASIDKGLQVAQKEAQIRLLEGRLRQTDMA 1068

Query: 1054 EDIERDMLCEDL---AHATEQLNMLTEASKKHSGLLQSAQE 1091
               +  +L + L   A A  +L  L    ++ +G   + +E
Sbjct: 1069 GSSQNHLLLDALREKAEAHPELQALIYNVQQENGYASTDEE 1109



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 105/504 (20%), Positives = 228/504 (45%), Gaps = 54/504 (10%)

Query: 861  ACLQDS-YDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQ 919
            AC+  S  D ++ +   +    +RN++N    N+   S     +  L AE  R     ++
Sbjct: 345  ACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQ---ISALRAEIARLQMELME 401

Query: 920  FEEDKENSSKEILKVLEAVRQEK---QKETAKCEQQMAKVQKLEESL------LATEKVI 970
            ++  K    ++  +    + +E    QKE      ++  +Q+  +++      L +++  
Sbjct: 402  YKAGKRVIGEDGAEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINNRVTQLMSQEAN 461

Query: 971  SSLEKSRDSDKKVVADLMN---QIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDRE 1027
              L K+ D ++ + A + N   +I+ELRT + E     ++L++ L   + +   +L    
Sbjct: 462  LLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSRASARSPYSLGASP 521

Query: 1028 ESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQ 1087
             +          + D  E +R     +D+ER    +       + +   EA KK + L Q
Sbjct: 522  AAPAFGGSPASSMEDASEVIRRA--KQDLER---LKKKEVRQRRKSPEKEAFKKRAKLQQ 576

Query: 1088 SAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPH 1147
               EE  + EA  +E + + ++   E E+ + + +      E ++DS + DP+  +   +
Sbjct: 577  ENSEETDENEA--EEEEEERDESGCEEEEGREDEDEDSGSEESLVDSDS-DPEEKEV--N 631

Query: 1148 FQTHLAKL---LETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENL 1204
            FQ  LA L   +E +++ I++   S+  L+ L  +  E       +++ ++ ++R+ +  
Sbjct: 632  FQADLADLTCEIEIKQKLIDELENSQRRLQTLKHQYEE-------KLILLQNKIRDTQ-- 682

Query: 1205 RLESQQLIEKNWLLQGQLDDIKRQKENSD------QNHPDNQQLKNEQEESIKERLAKSK 1258
             LE  ++++    ++   ++ K  K  +D      + + D Q+L+  Q+E  +    +S+
Sbjct: 683  -LERDRVLQNLSTMECYTEE-KANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSR 740

Query: 1259 IVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQE-----KEQLRSKLE 1313
               E+ K++A++ E++ A   K     +M +E +R + +E+K  +E     KEQ R + +
Sbjct: 741  YERELKKLQAEVAEMKKA---KVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQ 797

Query: 1314 EMYEERERTSQEMEMLRKQVECLA 1337
                E ++  QEM + RK  E  A
Sbjct: 798  IRALESQKRQQEMVLRRKTQEVSA 821



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 105/506 (20%), Positives = 206/506 (40%), Gaps = 86/506 (16%)

Query: 941  EKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVV------ADLMNQIQE- 993
            E+ K T    ++  +   +   LLA   VIS+L    D  KKVV      + L   +Q+ 
Sbjct: 278  ERLKRTGATGERAKEGISINCGLLALGNVISALG---DQSKKVVHVPYRDSKLTRLLQDS 334

Query: 994  ------------LRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDIL 1041
                        +  S  +  ET++TLK   +  N K N  +V+++++   I     +I 
Sbjct: 335  LGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIK-NKVVVNQDKTSQQISALRAEIA 393

Query: 1042 DLKETLR-----LRILSED---------IERDMLCEDLAHATEQLNMLTEA--------- 1078
             L+  L       R++ ED          E  ML ++      ++  + EA         
Sbjct: 394  RLQMELMEYKAGKRVIGEDGAEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINNRVT 453

Query: 1079 ---SKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSA 1135
               S++ + LL  A +      ALIQ    ++ + + ++ + +       R L     ++
Sbjct: 454  QLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSR---AS 510

Query: 1136 AEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMK 1195
            A  P S    P           + E   E  R +K  LE L  K     EV+       K
Sbjct: 511  ARSPYSLGASPAAPAFGGSPASSMEDASEVIRRAKQDLERLKKK-----EVRQRRKSPEK 565

Query: 1196 EQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESI--KER 1253
            E  ++   L+ E+ +  ++N        + + ++E  D++  + ++ + +++E    +E 
Sbjct: 566  EAFKKRAKLQQENSEETDEN--------EAEEEEEERDESGCEEEEGREDEDEDSGSEES 617

Query: 1254 LAKSKI--VEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSK 1311
            L  S     E+ +  +ADL ++   +  K+     + +   R QTL+ +  ++   L++K
Sbjct: 618  LVDSDSDPEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRLQTLKHQYEEKLILLQNK 677

Query: 1312 LEEMYEERERTSQEMEMLRKQVECLAEENGKLVGH------QNLHQKIQYVVRLKKENVR 1365
            + +   ER+R  Q +  +    EC  EE    +        + +++ +Q +   +KE+ R
Sbjct: 678  IRDTQLERDRVLQNLSTM----ECYTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHAR 733

Query: 1366 LAE-------ETEKLRAENVFLKEKK 1384
            L +       E +KL+AE   +K+ K
Sbjct: 734  LLKNQSRYERELKKLQAEVAEMKKAK 759


>gi|45446749 kinesin family member 5A [Homo sapiens]
          Length = 1032

 Score =  268 bits (685), Expect = 3e-71
 Identities = 259/927 (27%), Positives = 425/927 (45%), Gaps = 121/927 (13%)

Query: 68  KTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDN 127
           K + FD V   +TTQE V+   A  IV+  ++GYNGTIFAYGQT SGKT TM G      
Sbjct: 45  KPYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQ 104

Query: 128 FSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAGLYL 187
               L G+IPR    +F+ I    E       F  K S+ EIY ++I DLLD     L +
Sbjct: 105 ----LMGIIPRIARDIFNHIYSMDENL----EFHIKVSYFEIYLDKIRDLLDVTKTNLSV 156

Query: 188 REHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITI--E 245
            E   +  FV G  E+ V+S  E   V+  G  NR VA T+MN  SSRSH++F I I  E
Sbjct: 157 HEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQE 216

Query: 246 SMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDV 305
           +ME   ++    +  L LVDLAGSE+   T AEG  L EA NIN+SLS LG VI+AL + 
Sbjct: 217 NMETEQKL----SGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE- 271

Query: 306 GNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKN 365
             G + +V YRDSK+T +L+DSLGGN +T +     P S    ET STL F QRAK IKN
Sbjct: 272 --GTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKN 329

Query: 366 KAVVN------------EDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTN 413
            A VN            E  +      +  + +L+ +L+   +G+  PE+     ++   
Sbjct: 330 TASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEEAAL 389

Query: 414 YMEYFQE------AMLFFKKSEQEKKSLIEKVTQL-EDLTLKKEKFIQSNKMIVKFREDQ 466
             E  +E      + +  + + +E++   E++ +L + L  K ++  Q +++I K ++ Q
Sbjct: 390 GAELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQ-Q 448

Query: 467 IIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRR 526
           ++  E+L   +RG    E+  R LS L++E    +++++   +  +    N+        
Sbjct: 449 MLDQEELLVSTRGD--NEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYD------- 499

Query: 527 LRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKA 586
                  +++QE++                 EKS +NQ      +QK   + +   +L+ 
Sbjct: 500 -------QKSQEVE-----------------EKSQQNQLLVDELSQKVATMLSLESELQR 535

Query: 587 -------QLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKA 639
                  Q  +I   LN   ++  EF  +    +++L  E+    +    +  L      
Sbjct: 536 LQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARL------ 589

Query: 640 CKRQEVSQLNKIHAETLKIITTPTKAYQLH---SRPVPKLSPEMGSFGSLYTQNSS---I 693
                   ++KI +E   ++    +   L     R +     E+ S   L +Q+ +    
Sbjct: 590 -------YISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRS 642

Query: 694 LDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEE---------HKNLKLQ 744
           L   + +  +     E++++++S+EL  +Q Q +  +  L ++E          K L+LQ
Sbjct: 643 LTEYMQSVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALELQ 702

Query: 745 QHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLR 804
               +  HH  Q+  L   E  +  K  +EL      L+ +L++ Q   + LKSE H+  
Sbjct: 703 MESHREAHH-RQLARL-RDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKS 760

Query: 805 VVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQ 864
             L          +      K  +E    +L   H   +L + ++    +K  E +   +
Sbjct: 761 TKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEP--E 818

Query: 865 DS---YDNLQEIMKFE--IDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQ 919
           DS   +   Q+I   E  ++QL++  +   ++N  L+ +L  L + L A  ER   L   
Sbjct: 819 DSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGA 878

Query: 920 FEEDKENSSK-------EILKVLEAVR 939
            +E KE + K       E+ ++ EAVR
Sbjct: 879 LKEAKEGAMKDKRRYQQEVDRIKEAVR 905



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 123/639 (19%), Positives = 255/639 (39%), Gaps = 90/639 (14%)

Query: 626  ANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVP---KLSPEMGS 682
            A++NLE   E  K  K ++  +  K   ET+  +      ++ +   VP   +L+ E  +
Sbjct: 331  ASVNLELTAEQWKK-KYEKEKEKTKAQKETIAKLEAELSRWR-NGENVPETERLAGEEAA 388

Query: 683  FGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLK 742
             G+   + + + DN  +   + PE           E +  +E++  L  +LD+++ +  +
Sbjct: 389  LGAELCEETPVNDNSSIVVRIAPE-----------ERQKYEEEIRRLYKQLDDKDDEINQ 437

Query: 743  LQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHD 802
              Q ++KL+      +EL  S R D  K Q EL              Q++ND  K EV +
Sbjct: 438  QSQLIEKLKQQMLDQEELLVSTRGDNEKVQREL-----------SHLQSENDAAKDEVKE 486

Query: 803  LRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKAC 862
            +   L    +EL+           N +++  ++ E+    QL +D L  +   +L  ++ 
Sbjct: 487  VLQAL----EELA----------VNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESE 532

Query: 863  LQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEE 922
            LQ     LQE+   +  +++          E L   + +L E          KL ++   
Sbjct: 533  LQ----RLQEVSGHQRKRIA----------EVLNGLMKDLSEFSVIVGNGEIKLPVEISG 578

Query: 923  DKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKK 982
              E         +  ++ E +    +C Q      +    +  T + +SS +      + 
Sbjct: 579  AIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEA 638

Query: 983  VVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILD 1042
             +  L   +Q +        E+ D+L  EL  +  +            V +K +E D  D
Sbjct: 639  KIRSLTEYMQSVELKKRHLEESYDSLSDELAKLQAQ-------ETVHEVALKDKEPDTQD 691

Query: 1043 LKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQE 1102
              E  +   L  +  R+     LA   +++N                Q+ + + + L Q+
Sbjct: 692  ADEVKKALELQMESHREAHHRQLARLRDEIN--------------EKQKTIDELKDLNQK 737

Query: 1103 LQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQE 1162
            LQ +L + + + E+ K+E + K  +L+ +        QS +     +  +A+ L+T    
Sbjct: 738  LQLELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDLKGLEETVARELQTLH-- 795

Query: 1163 IEDGRASKTSLEHLVTKLNEDREVK---NAEILRMKEQLREMEN----LRLESQQLIEKN 1215
                   K  ++ + T++ +  E++   +  I   K+++  +EN    L    +QL+  N
Sbjct: 796  ----NLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDN 851

Query: 1216 WLLQGQLDDI-KRQKENSDQNHPDNQQLKNEQEESIKER 1253
              L+ +L  + KR +  +++       LK  +E ++K++
Sbjct: 852  ADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDK 890



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 88/448 (19%), Positives = 190/448 (42%), Gaps = 63/448 (14%)

Query: 924  KENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKV 983
            K  +S  +    E  +++ +KE  K + Q   + KLE  L       +  E  R      
Sbjct: 328  KNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETER------ 381

Query: 984  VADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDR----------EESRVLI 1033
               L  +   L   +CE+T   D             NS++V R          EE R L 
Sbjct: 382  ---LAGEEAALGAELCEETPVND-------------NSSIVVRIAPEERQKYEEEIRRLY 425

Query: 1034 KKQEVDILDLKETLRLRILSEDIERDMLC-EDLAHATEQLNMLTEASKKHSGLLQS---- 1088
            K+ +    ++ +  +L    E +++ ML  E+L  +T   N   +    H   LQS    
Sbjct: 426  KQLDDKDDEINQQSQL---IEKLKQQMLDQEELLVSTRGDNEKVQRELSH---LQSENDA 479

Query: 1089 AQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEH----VMDSAAEDPQSPKT 1144
            A++E+ +    ++EL    +QK +EVE+K  +    + +L      ++   +E  +  + 
Sbjct: 480  AKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEV 539

Query: 1145 PPHFQTHLAKLLETQEQEIED-----GRASKTSLEHLVTKLNEDREVKNAEILRMKEQL- 1198
              H +  +A++L    +++ +     G         +   + E+  V    I ++K ++ 
Sbjct: 540  SGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVK 599

Query: 1199 ------REMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKE 1252
                  R++ENL++E  + +E           +  Q E   ++  +  Q    ++  ++E
Sbjct: 600  SVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQSVELKKRHLEE 659

Query: 1253 RLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLR-SK 1311
              +   + +E+ K++A     + AL +KE +  +  DEV++   L+ ++ +E    + ++
Sbjct: 660  --SYDSLSDELAKLQAQETVHEVALKDKEPD-TQDADEVKKALELQMESHREAHHRQLAR 716

Query: 1312 LEEMYEERERTSQEMEMLRKQVECLAEE 1339
            L +   E+++T  E++ L ++++   E+
Sbjct: 717  LRDEINEKQKTIDELKDLNQKLQLELEK 744



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 94/499 (18%), Positives = 215/499 (43%), Gaps = 66/499 (13%)

Query: 879  DQLSRNLQNFKKENETLKSDLNNLMELL-EAEKERNNKLSLQFEEDKENSSKEILKVLEA 937
            D  +++   F +  +T+K+  +  +EL  E  K++  K     E++K  + KE +  LEA
Sbjct: 311  DAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEK-----EKEKTKAQKETIAKLEA 365

Query: 938  VRQ-----EKQKETAKC--EQQMAKVQKLEESLLATEK--VISSLEKSRDSDKKVVADLM 988
                    E   ET +   E+     +  EE+ +      V+    + R   ++ +  L 
Sbjct: 366  ELSRWRNGENVPETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLY 425

Query: 989  NQIQELRTSVCEKTETIDTLKQELKD-----INCKYNSALVDREESRVLIKKQEVDILDL 1043
             Q+ +    + ++++ I+ LKQ++ D     ++ + ++  V RE S  L  + +    ++
Sbjct: 426  KQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSH-LQSENDAAKDEV 484

Query: 1044 KETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQEL 1103
            KE L+              E+LA   +Q +   E   + + LL    +EL++K A +  L
Sbjct: 485  KEVLQA------------LEELAVNYDQKSQEVEEKSQQNQLLV---DELSQKVATMLSL 529

Query: 1104 QHKLNQKKEEVEQKKNEY----NFKMRQLEH----VMDSAAEDPQSPKTPPHFQTHLAKL 1155
            + +L + +E    ++       N  M+ L      V +   + P         +  +A+L
Sbjct: 530  ESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARL 589

Query: 1156 LETQ-EQEIEDGRASKTSLEHLVTKLNEDREVKNAEI-----------LRMKEQLREMEN 1203
              ++ + E++        LE+L  + +   EV   E+            +++     M++
Sbjct: 590  YISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQS 649

Query: 1204 LRLESQQLIEKNWLLQGQLDDIKRQKENSD----QNHPDNQQLKNEQEESIKERLAKSKI 1259
            + L+ + L E    L  +L  ++ Q+   +       PD Q   +E +++++ ++   + 
Sbjct: 650  VELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDA-DEVKKALELQMESHRE 708

Query: 1260 VE--EMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEE--- 1314
                ++ +++ ++ E Q  +   +    ++  E+E+ Q    K   E+ +  +KL+E   
Sbjct: 709  AHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTF 768

Query: 1315 MYEERERTSQEMEMLRKQV 1333
            +YE  E++ Q+++ L + V
Sbjct: 769  LYERHEQSKQDLKGLEETV 787



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 46/209 (22%), Positives = 94/209 (44%), Gaps = 17/209 (8%)

Query: 1160 EQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQ 1219
            E+E E  +A K ++  L  +L+  R   N E +   E+L   E       +L E+  +  
Sbjct: 347  EKEKEKTKAQKETIAKLEAELSRWR---NGENVPETERLAGEEAAL--GAELCEETPVND 401

Query: 1220 GQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYN 1279
                 ++   E   +   + ++L  + ++   E   +S+++E++ +   D EE+   L +
Sbjct: 402  NSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEEL---LVS 458

Query: 1280 KEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEE 1339
               +  ++  E+   Q+    A  E +++   LEE+    ++ SQE+E   +Q + L +E
Sbjct: 459  TRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDE 518

Query: 1340 NGKLVGHQNLHQKIQYVVRLKKENVRLAE 1368
                     L QK+  ++ L+ E  RL E
Sbjct: 519  ---------LSQKVATMLSLESELQRLQE 538


>gi|30794488 kinesin family member 27 [Homo sapiens]
          Length = 1401

 Score =  266 bits (680), Expect = 1e-70
 Identities = 331/1320 (25%), Positives = 575/1320 (43%), Gaps = 184/1320 (13%)

Query: 27   IKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPEPKTFTFDHVADVDTTQESVF 86
            +KV VRIRP   +   A     +C+ V+ ++   +      + FTFD V   ++TQ+ V+
Sbjct: 6    VKVAVRIRPLLCKE--ALHNHQVCVRVIPNSQQVIIGRD--RVFTFDFVFGKNSTQDEVY 61

Query: 87   ATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEYLFSL 146
             T  K +V S + GYN T+FAYGQTGSGKT+T+ G     +     +G+IPR+ + +F  
Sbjct: 62   NTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTI-GGGHIASVVEGQKGIIPRAIQEIFQS 120

Query: 147  IDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLD--SASAGLYLREHIKKGVFVVGAVEQV 204
            I            F  K S+IE+Y E + DLL+  ++   L++RE  K    +VGA E  
Sbjct: 121  ISEHPSI-----DFNVKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECH 175

Query: 205  VTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNEIVNIRT------ 258
            V SA E   +L  G   R   +T MN  SSRSHA+FTI+I  + K+ E     +      
Sbjct: 176  VESAGEVMSLLEMGNAARHTGTTQMNEHSSRSHAIFTISICQVHKNMEAAEDGSWYSPRH 235

Query: 259  --SLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYR 316
              S  + VDLAGSER   T   G R KE+  IN  L  LG VI+AL D    K  H+ YR
Sbjct: 236  IVSKFHFVDLAGSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRR-KSSHIPYR 294

Query: 317  DSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGN 376
            D+K+T LL+DSLGG+AKT +I  V P S  F E+L++L +A RA+ I+NK  VN   + +
Sbjct: 295  DAKITRLLKDSLGGSAKTVMITCVSPSSSNFDESLNSLKYANRARNIRNKPTVNFSPESD 354

Query: 377  -VSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKKSL 435
             + +++ E+K L+E L    +G +            TN +                  SL
Sbjct: 355  RIDEMEFEIKLLREALQSQQAGVSQTTQINREGSPDTNRIH-----------------SL 397

Query: 436  IEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRN 495
             E+V QL+   L  +  ++     +   +D +              L E+Q   L E  N
Sbjct: 398  EEQVAQLQGECLGYQCCVEEAFTFLVDLKDTV-------------RLNEKQQHKLQEWFN 444

Query: 496  EIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEIS 555
             IQ +R+ +    R         SL E  + + +L+ +KR  +     +A  E  F++  
Sbjct: 445  MIQEVRKAVLTSFRGIG---GTASLEEGPQHVTVLQ-LKRELKKCQCVLAADEVVFNQKE 500

Query: 556  GMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQLE 615
               K  KNQ     +  K   + +  E  K   LQ                E   ++QL 
Sbjct: 501  LEVKELKNQVQMMVQENKGHAV-SLKEAQKVNRLQ---------------NEKIIEQQLL 544

Query: 616  LESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPK 675
            ++   + L K NL++ +   A + C     +++ +    T+   T       + SR   +
Sbjct: 545  VDQLSEELTKLNLSVTS--SAKENCGDGPDARIPERRPYTVPFDTHLGHYIYIPSRQDSR 602

Query: 676  ---LSPEMGS----FGSLYTQNSSIL-----DNDILNEPVPPEMNEQAFEAISEELRTVQ 723
                SP M S    F    T++  +L      + +L+       +++  E   E+  T  
Sbjct: 603  KVHTSPPMYSLDRIFAGFRTRSQMLLGHIEEQDKVLHCQFSDNSDDEESEG-QEKSGTRC 661

Query: 724  EQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEEL-LSQLNVL 782
               S +Q    +     ++L    D+ +    + ++L    +ID  ++ +EL L +L   
Sbjct: 662  RSRSWIQK--PDSVCSLVELSDTQDETQKSDLENEDL----KIDCLQESQELNLQKLKNS 715

Query: 783  EKQLQETQTKNDFLKSEV---HDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERH 839
            E+ L E + K   L   +    DL   L     +  SV  +YS   T  E +  +     
Sbjct: 716  ERILTEAKQKMRELTINIKMKEDLIKELIKTGNDAKSVSKQYSLKVTKLEHDAEQAKVEL 775

Query: 840  MHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKK------ENE 893
            +  Q QL  L  ++   +  K  LQ  +    +  K  +  L +  Q+ KK      +NE
Sbjct: 776  IETQKQLQELENKDLSDVAMKVKLQKEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNE 835

Query: 894  TLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQM 953
               ++L   ++ ++ +     K+ LQ +  +EN  +   K L+AV +  Q++  + + + 
Sbjct: 836  KRANELEQSVDHMKYQ-----KIQLQRKLREENEKR---KQLDAVIKRDQQKIKEIQLKT 887

Query: 954  AKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELK 1013
             +    EE L    + + +    R        D + ++ E +  + E+ E +   +QEL+
Sbjct: 888  GQ----EEGLKPKAEDLDACNLKRRKGSFGSIDHLQKLDEQKKWLDEEVEKVLNQRQELE 943

Query: 1014 DI--NCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQ 1071
            ++  + K   A+V ++E+ +L +K  ++   L+ +  L              D    + +
Sbjct: 944  ELEADLKKREAIVSKKEA-LLQEKSHLENKKLRSSQALN------------TDSLKISTR 990

Query: 1072 LNML-TEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEH 1130
            LN+L  E S+K+  L  S  EE TK    I E    L ++K++++++++  + K++    
Sbjct: 991  LNLLEQELSEKNVQLQTSTAEEKTK----ISEQVEVLQKEKDQLQKRRHNVDEKLKN--- 1043

Query: 1131 VMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAE 1190
                                   ++L  +E+ +         LE  +  L    E +N  
Sbjct: 1044 ----------------------GRVLSPEEEHV------LFQLEEGIEALEAAIEYRNES 1075

Query: 1191 ILRMKEQLR-EMENLRLESQQLIEKNWLLQG-QLDDIKRQKENSDQNHPDNQQLKNEQEE 1248
            I   ++ LR    NL      ++EK   L   ++  I  +  N         ++ N +E 
Sbjct: 1076 IQNRQKSLRASFHNLSRGEANVLEKLACLSPVEIRTILFRYFN---------KVVNLREA 1126

Query: 1249 SIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQL 1308
              K++L   ++  ++L+    + E++SAL + +++C       +R  TL+ K  ++K QL
Sbjct: 1127 ERKQQLYNEEMKMKVLERDNMVRELESALDHLKLQC-------DRRLTLQQKEHEQKMQL 1179



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 145/765 (18%), Positives = 302/765 (39%), Gaps = 73/765 (9%)

Query: 654  ETLKIITTPTKAYQLHSRPVPKLSPEMGSFG-----------SLYTQNSSILDNDILNEP 702
            E+L  +    +A  + ++P    SPE                +L +Q + +     +N  
Sbjct: 327  ESLNSLKYANRARNIRNKPTVNFSPESDRIDEMEFEIKLLREALQSQQAGVSQTTQINRE 386

Query: 703  VPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELF- 761
              P+ N     ++ E++  +Q +    Q  ++E     + L+  V   E    ++QE F 
Sbjct: 387  GSPDTNR--IHSLEEQVAQLQGECLGYQCCVEEAFTFLVDLKDTVRLNEKQQHKLQEWFN 444

Query: 762  -----------SSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSA 810
                       S   I  T   EE    + VL+            LK E+   + VL + 
Sbjct: 445  MIQEVRKAVLTSFRGIGGTASLEEGPQHVTVLQ------------LKRELKKCQCVLAAD 492

Query: 811  DKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNL 870
            +   +  +LE    K   +    +     + ++      RL+NEK++E +  +    D L
Sbjct: 493  EVVFNQKELEVKELKNQVQMMVQENKGHAVSLKEAQKVNRLQNEKIIEQQLLV----DQL 548

Query: 871  QEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKE 930
             E    E+ +L+ ++ +  KEN     D   + E        +  L           S++
Sbjct: 549  SE----ELTKLNLSVTSSAKENCGDGPDAR-IPERRPYTVPFDTHLGHYIYIPSRQDSRK 603

Query: 931  ILKVLEAVRQEKQKETAKCEQQM--AKVQKLEESLLATEKVISSLEKSRDSDKKVVADLM 988
            +         ++     +   QM    +++ ++ L       S  E+S   +K       
Sbjct: 604  VHTSPPMYSLDRIFAGFRTRSQMLLGHIEEQDKVLHCQFSDNSDDEESEGQEKSGTRCRS 663

Query: 989  NQIQELRTSVCEKTETIDTL----KQELKDINCKYNSALVDREESRVLIKKQEVDILDLK 1044
                +   SVC   E  DT     K +L++ + K +     +E +   +K  E  + + K
Sbjct: 664  RSWIQKPDSVCSLVELSDTQDETQKSDLENEDLKIDCLQESQELNLQKLKNSERILTEAK 723

Query: 1045 ETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQE---ELTKKEALIQ 1101
            + +R   ++  ++ D++ E +    +  ++  + S K + L   A++   EL + +  +Q
Sbjct: 724  QKMRELTINIKMKEDLIKELIKTGNDAKSVSKQYSLKVTKLEHDAEQAKVELIETQKQLQ 783

Query: 1102 ELQHK-LNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQE 1160
            EL++K L+    +V+ +K E+  KM   +  +    +  Q  K          K     E
Sbjct: 784  ELENKDLSDVAMKVKLQK-EFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRANELE 842

Query: 1161 QEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQG 1220
            Q ++  +  K  L+  + + NE R+  +A I R +++++E++    + + L  K      
Sbjct: 843  QSVDHMKYQKIQLQRKLREENEKRKQLDAVIKRDQQKIKEIQLKTGQEEGLKPK----AE 898

Query: 1221 QLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNK 1280
             LD    ++        D+ Q  +EQ++ + E       VE++L  + +LEE+++ L  +
Sbjct: 899  DLDACNLKRRKGSFGSIDHLQKLDEQKKWLDEE------VEKVLNQRQELEELEADLKKR 952

Query: 1281 EMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVE-CLAEE 1339
            E    +    ++    LE+K  +  + L +   ++        QE+     Q++   AEE
Sbjct: 953  EAIVSKKEALLQEKSHLENKKLRSSQALNTDSLKISTRLNLLEQELSEKNVQLQTSTAEE 1012

Query: 1340 NGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFLKEKK 1384
              K+     + QK +  ++ ++ NV      EKL+   V   E++
Sbjct: 1013 KTKISEQVEVLQKEKDQLQKRRHNV-----DEKLKNGRVLSPEEE 1052



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 136/666 (20%), Positives = 281/666 (42%), Gaps = 95/666 (14%)

Query: 487  DRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAK 546
            DR+ +  R   Q L   IE   +V      ++S  EE+         +       ++ + 
Sbjct: 614  DRIFAGFRTRSQMLLGHIEEQDKVLHCQFSDNSDDEESEG-------QEKSGTRCRSRSW 666

Query: 547  LEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFK 606
            ++K  S  S +E SD   +  + K+  E       E LK   LQ   ELN  K +  E +
Sbjct: 667  IQKPDSVCSLVELSDTQDE--TQKSDLE------NEDLKIDCLQESQELNLQKLKNSE-R 717

Query: 607  ELTRKRQLELESELQSLQKANLNLENLLEA---TKACKRQEVSQLNKIHAET----LKII 659
             LT  +Q   E  +    K +L ++ L++     K+  +Q   ++ K+  +     +++I
Sbjct: 718  ILTEAKQKMRELTINIKMKEDL-IKELIKTGNDAKSVSKQYSLKVTKLEHDAEQAKVELI 776

Query: 660  TTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEEL 719
             T  +  +L ++ +  ++ ++     L  +    +D   L   V               L
Sbjct: 777  ETQKQLQELENKDLSDVAMKV----KLQKEFRKKMDAAKLRVQV---------------L 817

Query: 720  RTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQL 779
            +  Q+    L +   + E +  +L+Q VD +++   Q+Q     E  +  KQ + ++ + 
Sbjct: 818  QKKQQDSKKLASLSIQNEKRANELEQSVDHMKYQKIQLQRKLREEN-EKRKQLDAVIKRD 876

Query: 780  NVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERH 839
                K++Q    + + LK +  DL         +  ++K    SF         KL E+ 
Sbjct: 877  QQKIKEIQLKTGQEEGLKPKAEDL---------DACNLKRRKGSF--GSIDHLQKLDEQK 925

Query: 840  MHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFK-KENETLKSD 898
              +  +++ +  + ++L E +A L+     + +  K  + Q   +L+N K + ++ L +D
Sbjct: 926  KWLDEEVEKVLNQRQELEELEADLKKREAIVSK--KEALLQEKSHLENKKLRSSQALNTD 983

Query: 899  ---LNNLMELLEAE-KERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMA 954
               ++  + LLE E  E+N +L     E+K   S+++ +VL+  + + QK     ++++ 
Sbjct: 984  SLKISTRLNLLEQELSEKNVQLQTSTAEEKTKISEQV-EVLQKEKDQLQKRRHNVDEKLK 1042

Query: 955  K-----------VQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTE 1003
                        + +LEE + A E  I    +S  + +K +    + +     +V EK  
Sbjct: 1043 NGRVLSPEEEHVLFQLEEGIEALEAAIEYRNESIQNRQKSLRASFHNLSRGEANVLEKLA 1102

Query: 1004 TIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCE 1063
             +  +  E++ I  +Y + +V+  E+    +KQ++      E +++++L    ERD +  
Sbjct: 1103 CLSPV--EIRTILFRYFNKVVNLREAE---RKQQL----YNEEMKMKVL----ERDNMVR 1149

Query: 1064 DLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNF 1123
            +L  A + L +  +        L   Q+E  +K  L+  L H   Q  E + +    Y  
Sbjct: 1150 ELESALDHLKLQCDRR------LTLQQKEHEQKMQLL--LHHFKEQDGEGIMETFKTYED 1201

Query: 1124 KMRQLE 1129
            K++QLE
Sbjct: 1202 KIQQLE 1207



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 92/533 (17%), Positives = 225/533 (42%), Gaps = 50/533 (9%)

Query: 858  ESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLS 917
            +S   L +  D   E  K +++     +   ++  E     L N   +L   K++  +L+
Sbjct: 671  DSVCSLVELSDTQDETQKSDLENEDLKIDCLQESQELNLQKLKNSERILTEAKQKMRELT 730

Query: 918  LQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSR 977
            +  +  KE+  KE++K     +   ++ + K  +     ++ +  L+ T+K +  LE   
Sbjct: 731  INIKM-KEDLIKELIKTGNDAKSVSKQYSLKVTKLEHDAEQAKVELIETQKQLQELENKD 789

Query: 978  DSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQE 1037
             SD  +   L  + ++   +   + + +   +Q+ K +     ++L  + E R    +Q 
Sbjct: 790  LSDVAMKVKLQKEFRKKMDAAKLRVQVLQKKQQDSKKL-----ASLSIQNEKRANELEQS 844

Query: 1038 VDILDL-KETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQE----E 1092
            VD +   K  L+ ++  E+ +R  L   +    +++  +   + +  GL   A++     
Sbjct: 845  VDHMKYQKIQLQRKLREENEKRKQLDAVIKRDQQKIKEIQLKTGQEEGLKPKAEDLDACN 904

Query: 1093 LTKKEALIQELQH--KLNQKK----EEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPP 1146
            L +++     + H  KL+++K    EEVE+  N+   ++ +LE  +          +   
Sbjct: 905  LKRRKGSFGSIDHLQKLDEQKKWLDEEVEKVLNQRQ-ELEELEADLKKREAIVSKKEALL 963

Query: 1147 HFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRL 1206
              ++HL      + +++   +A  T    + T+LN            + EQ    +N++L
Sbjct: 964  QEKSHL------ENKKLRSSQALNTDSLKISTRLN------------LLEQELSEKNVQL 1005

Query: 1207 ESQQLIEKNWLLQGQLDDIKRQKEN-SDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLK 1265
            ++    EK  + + Q++ ++++K+    + H  +++LKN +  S +E     ++ E +  
Sbjct: 1006 QTSTAEEKTKISE-QVEVLQKEKDQLQKRRHNVDEKLKNGRVLSPEEEHVLFQLEEGIEA 1064

Query: 1266 MKADLEEVQSALYNKEMECLRMTDEVER--TQTLESKAFQEKEQLRS----------KLE 1313
            ++A +E    ++ N++         + R     LE  A     ++R+           L 
Sbjct: 1065 LEAAIEYRNESIQNRQKSLRASFHNLSRGEANVLEKLACLSPVEIRTILFRYFNKVVNLR 1124

Query: 1314 EMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRL 1366
            E   +++  ++EM+M   + + +  E    + H  L    +  ++ K+   ++
Sbjct: 1125 EAERKQQLYNEEMKMKVLERDNMVRELESALDHLKLQCDRRLTLQQKEHEQKM 1177



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 111/612 (18%), Positives = 235/612 (38%), Gaps = 137/612 (22%)

Query: 862  CLQDSYDNLQEIMK-FEIDQLSRNLQNFKKENETLKSDLNNLME-----LLEAEKERNNK 915
            C+  S  N  E +   +    +RN++N    N + +SD  + ME     L EA + +   
Sbjct: 317  CVSPSSSNFDESLNSLKYANRARNIRNKPTVNFSPESDRIDEMEFEIKLLREALQSQQAG 376

Query: 916  LSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEK 975
            +S   + ++E S       + ++ ++  +   +C      V++    L+  +  +   EK
Sbjct: 377  VSQTTQINREGSPDT--NRIHSLEEQVAQLQGECLGYQCCVEEAFTFLVDLKDTVRLNEK 434

Query: 976  SRDSDKKVVADLMNQIQELRTSVCEKTE---------------TIDTLKQELKDINCKYN 1020
             +      + +  N IQE+R +V                    T+  LK+ELK   C   
Sbjct: 435  QQHK----LQEWFNMIQEVRKAVLTSFRGIGGTASLEEGPQHVTVLQLKRELKKCQCVLA 490

Query: 1021 SALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASK 1080
            +         V+  ++E+++ +LK                          Q+ M+ + +K
Sbjct: 491  A-------DEVVFNQKELEVKELKN-------------------------QVQMMVQENK 518

Query: 1081 KHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQ 1140
             H+  L+ AQ+    +   I E Q  ++Q  EE+     + N  +            D +
Sbjct: 519  GHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSEEL----TKLNLSVTSSAKENCGDGPDAR 574

Query: 1141 SPKTPPH---FQTHLAKLLETQEQEIEDGRASKTS----------------LEHLVTKLN 1181
             P+  P+   F THL   +    +  +D R   TS                 + L+  + 
Sbjct: 575  IPERRPYTVPFDTHLGHYIYIPSR--QDSRKVHTSPPMYSLDRIFAGFRTRSQMLLGHIE 632

Query: 1182 EDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQG-------QLDDIKRQKENSDQ 1234
            E  +V + +     +   E E       +   ++W+ +        +L D + + + SD 
Sbjct: 633  EQDKVLHCQFSDNSDD-EESEGQEKSGTRCRSRSWIQKPDSVCSLVELSDTQDETQKSDL 691

Query: 1235 NHPD-------------NQQLKN------EQEESIKERL----AKSKIVEEMLKMKADLE 1271
             + D              Q+LKN      E ++ ++E       K  +++E++K   D +
Sbjct: 692  ENEDLKIDCLQESQELNLQKLKNSERILTEAKQKMRELTINIKMKEDLIKELIKTGNDAK 751

Query: 1272 EVQSAL--------YNKEMECLRMTDEVERTQTLESKAFQE-------KEQLRSKLE--- 1313
             V            ++ E   + + +  ++ Q LE+K   +       +++ R K++   
Sbjct: 752  SVSKQYSLKVTKLEHDAEQAKVELIETQKQLQELENKDLSDVAMKVKLQKEFRKKMDAAK 811

Query: 1314 ---EMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEET 1370
               ++ +++++ S+++  L  Q E  A E  + V H   +QKIQ   +L++EN +  +  
Sbjct: 812  LRVQVLQKKQQDSKKLASLSIQNEKRANELEQSVDHMK-YQKIQLQRKLREENEKRKQLD 870

Query: 1371 EKLRAENVFLKE 1382
              ++ +   +KE
Sbjct: 871  AVIKRDQQKIKE 882



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 64/314 (20%), Positives = 138/314 (43%), Gaps = 26/314 (8%)

Query: 1086 LQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTP 1145
            L   Q+E  K +   ++L+    Q+ +E+  +K      ++  E ++  A +  +     
Sbjct: 679  LSDTQDETQKSDLENEDLKIDCLQESQELNLQK------LKNSERILTEAKQKMRELTIN 732

Query: 1146 PHFQTHLAK-LLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENL 1204
               +  L K L++T      D ++        VTKL  D E    E++  ++QL+E+EN 
Sbjct: 733  IKMKEDLIKELIKTGN----DAKSVSKQYSLKVTKLEHDAEQAKVELIETQKQLQELENK 788

Query: 1205 RLESQQL-IEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEM 1263
             L    + ++     + ++D  K + +   +   D+++L +   ++ K      + V+ M
Sbjct: 789  DLSDVAMKVKLQKEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRANELEQSVDHM 848

Query: 1264 LKMKADLEEV--QSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYE---E 1318
               K  L+    +     K+++ +   D+ ++ + ++ K  QE E L+ K E++     +
Sbjct: 849  KYQKIQLQRKLREENEKRKQLDAVIKRDQ-QKIKEIQLKTGQE-EGLKPKAEDLDACNLK 906

Query: 1319 RERTS----QEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLR 1374
            R + S      ++ L +Q + L EE  K++   N  Q+++ +    K+   +  + E L 
Sbjct: 907  RRKGSFGSIDHLQKLDEQKKWLDEEVEKVL---NQRQELEELEADLKKREAIVSKKEALL 963

Query: 1375 AENVFLKEKKRSES 1388
             E   L+ KK   S
Sbjct: 964  QEKSHLENKKLRSS 977


>gi|38569484 kinesin family member 21A [Homo sapiens]
          Length = 1661

 Score =  263 bits (671), Expect = 1e-69
 Identities = 280/1052 (26%), Positives = 464/1052 (44%), Gaps = 167/1052 (15%)

Query: 26   AIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPEPKTFTFDHVADVDTTQESV 85
            +++V VRIRP   +    +G  ++C SV            + K FTFD+V D+D+ QE +
Sbjct: 9    SVRVAVRIRPQLAKE-KIEG-CHICTSVTPGEPQVFLG--KDKAFTFDYVFDIDSQQEQI 64

Query: 86   FATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEYLFS 145
            +    + ++E C  GYN T+FAYGQTG+GKT+TM G     N      G+I R+ ++LF 
Sbjct: 65   YIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTM-GTGFDVNIVEEELGIISRAVKHLFK 123

Query: 146  LIDREKE---KAGA-GKSFLCKCSFIEIYNEQIYDLLD--------SASAGLYLREHIKK 193
             I+ +K    K G     F     F+E+YNE++ DL D        S  + + + E    
Sbjct: 124  SIEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLFDTTRDIDAKSKKSNIRIHEDSTG 183

Query: 194  GVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTI----------- 242
            G++ VG   + V + +E  Q L  G  +R  AST MN +SSRSHA+FTI           
Sbjct: 184  GIYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQI 243

Query: 243  ---------TIESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLS 293
                      I    + NE   + T+  + VDLAGSER K T A G R KE  +IN  L 
Sbjct: 244  DADNATDNKIISESAQMNEFETL-TAKFHFVDLAGSERLKRTGATGERAKEGISINCGLL 302

Query: 294  CLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLST 353
             LG VI+AL D    +  HV YRDSKLT LL+DSLGGN++T +IA V P  R F ETL+T
Sbjct: 303  ALGNVISALGDKSK-RATHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNT 361

Query: 354  LNFAQRAKLIKNKAVVNED-TQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKT 412
            L +A RA+ IKNK +VN+D     ++ L++E+ RL+ +L E  +G    +  +  +  ++
Sbjct: 362  LKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMELMEYKTG----KRIIDEEGVES 417

Query: 413  NYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEK 472
                + + AML     + E  +L  ++           K +Q     ++ R  Q++  + 
Sbjct: 418  INDMFHENAML-----QTENNNLRVRI-----------KAMQETVDALRSRITQLVSDQA 461

Query: 473  LHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEP 532
             H  +R G   EE   ++     EI+ LR ++     V      N +LR+   R     P
Sbjct: 462  NHVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAV------NENLRKNLTRATARAP 515

Query: 533  VKRAQEMDAQTIAKLEKAFSEISGMEKSD------KNQQGFSPKAQKEPCLFANTEKLKA 586
                    + TI   +K   EI  + K D      K ++     A KE     + EK + 
Sbjct: 516  YFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKSVAGKEDNTDTDQEKKEE 575

Query: 587  QLLQIQTELNNSKQEYEEFKELTRKRQLEL----------------ESELQSLQKANLNL 630
            + +   +E  N++ E EE +E++     E                 ES+ +S +KAN   
Sbjct: 576  KGV---SERENNELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQA 632

Query: 631  E------NLLEATKACKRQEVSQ-----LNKIHAETLKIITTPTKAYQLHSRPVPKLSPE 679
            +       +    K     E SQ     L K + E L ++    +  QL    V +    
Sbjct: 633  DLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQ---N 689

Query: 680  MGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHK 739
            +GS  S   + +  + ++        E   QA     + L+  Q++ + L     + E +
Sbjct: 690  LGSVESYSEEKAKKVRSEY-------EKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQ 742

Query: 740  NLKLQQHVDKLEHHST----QMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKND- 794
              KLQQ V +++        QM+E     R+  +++  E+         QL++ Q K D 
Sbjct: 743  LKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREI--------AQLKKDQRKRDH 794

Query: 795  ---FLKSEVHDLRVVLHSADKELSSVKLEYSSFKTN-QEKEFNKLSERHMHVQ------- 843
                L+++  +  VVL    +E+++++ +          K   KLS      Q       
Sbjct: 795  QLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAA 854

Query: 844  --------------LQLDNLRLE---------NEKLLESKACLQDSYDNLQEIMKFEIDQ 880
                          +++   R++         N K  + K      + +    MK+++  
Sbjct: 855  AVETDASRTGAQQKMRIPVARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQL-- 912

Query: 881  LSRNLQNFKKENET---LKSDLNNLMELLEAEKERNNKLSLQFEE-DKENSSKEILKVLE 936
            L R + +   +  T   +++D+N L++  E   +R  KLS + E+  KEN   +  K + 
Sbjct: 913  LERRVTDIIMQKMTISNMEADMNRLLKQREELTKRREKLSKRREKIVKENGEGD--KNVA 970

Query: 937  AVRQEKQKETAKCEQQMAKVQKLEESLLATEK 968
             + +E +  TA  +     +   + +++  E+
Sbjct: 971  NINEEMESLTANIDYINDSISDCQANIMQMEE 1002



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 119/660 (18%), Positives = 277/660 (41%), Gaps = 102/660 (15%)

Query: 716  SEELRTVQEQMSALQAKLDE-EEHKNLKLQQHVDKLE---HHSTQMQELFSSERIDWTKQ 771
            S+++  ++ +++ LQ +L E +  K +  ++ V+ +    H +  +Q   ++ R+   K 
Sbjct: 383  SQQINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVR-IKA 441

Query: 772  QEELLSQLNVLEKQLQETQTKNDFLKSEV--HDLRVVLHSADKELSSVK---LEYSSFKT 826
             +E +  L     QL   Q  +   ++     ++  ++HS  KE+  ++   LE  +   
Sbjct: 442  MQETVDALRSRITQLVSDQANHVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAVNE 501

Query: 827  NQEKEFNKLSERHMH------------------------VQLQLDNLRLENEKLLESKAC 862
            N  K   + + R  +                         +  L+ L+ + ++  +S A 
Sbjct: 502  NLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKSVAG 561

Query: 863  LQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEE 922
             +D+ D  QE                KKE + +    NN +E+ E+++  +++   + EE
Sbjct: 562  KEDNTDTDQE----------------KKEEKGVSERENNELEVEESQEVSDHEDEEEEEE 605

Query: 923  DKENS--SKEILKVLEAVRQEK---QKETAKCEQQMAKVQKLEESLLATEKVISSLEKSR 977
            ++E+     E     ++   EK   Q + A    ++A  QKL + L  ++K + +L+K  
Sbjct: 606  EEEDDIDGGESSDESDSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQY 665

Query: 978  DSDKKVVADLMNQIQELRTSVCEKTETIDTLKQE-LKDINCKYNSAL------------V 1024
            +    ++   +   Q  R  V +   ++++  +E  K +  +Y   L             
Sbjct: 666  EEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQAA 725

Query: 1025 DREESRVL---------IKKQEVDILDLKET-LRL-RILSEDIERDMLCEDLAHATEQLN 1073
             +E +R+L         +KK + D++++K+T +RL + + E+ E+  L E  +    ++ 
Sbjct: 726  QKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTE--SRRNREIA 783

Query: 1074 MLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMD 1133
             L +  +K    L+  + +   +E +++    ++   + +V    ++   K+ +     D
Sbjct: 784  QLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSD 843

Query: 1134 SAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKN----- 1188
            + A+D  S       +T  ++    Q+  I   R    +L    T  N  +  +      
Sbjct: 844  APAQDTGSSAAA--VETDASRTGAQQKMRIPVARVQ--ALPTPATNGNRKKYQRKGLTGR 899

Query: 1189 ---AEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNE 1245
               ++  RMK QL E     +  Q++   N  ++  ++ + +Q+E   +     ++L   
Sbjct: 900  VFISKTARMKWQLLERRVTDIIMQKMTISN--MEADMNRLLKQREELTKRR---EKLSKR 954

Query: 1246 QEESIKERLAKSKIV----EEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKA 1301
            +E+ +KE     K V    EEM  + A+++ +  ++ + +   ++M +  E  +TL+  A
Sbjct: 955  REKIVKENGEGDKNVANINEEMESLTANIDYINDSISDCQANIMQMEEAKEEGETLDVTA 1014



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 111/539 (20%), Positives = 233/539 (43%), Gaps = 84/539 (15%)

Query: 906  LEAEKERNNKL---SLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEES 962
            ++A+   +NK+   S Q  E +  ++K     ++    E+ K T    ++  +   +   
Sbjct: 243  IDADNATDNKIISESAQMNEFETLTAK--FHFVDLAGSERLKRTGATGERAKEGISINCG 300

Query: 963  LLATEKVISSL-EKS--------RDSD-KKVVADLMNQIQELRTSVC------EKTETID 1006
            LLA   VIS+L +KS        RDS   +++ D +    +     C      +  ET++
Sbjct: 301  LLALGNVISALGDKSKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLN 360

Query: 1007 TLKQELKDINCKYNSALVDREES-------RVLIKKQEVDILDLKETLRLRILSEDIE-- 1057
            TLK   +  N K N  +V+++ +       R  I + ++++++ K   R+ I  E +E  
Sbjct: 361  TLKYANRARNIK-NKVMVNQDRASQQINALRSEITRLQMELMEYKTGKRI-IDEEGVESI 418

Query: 1058 RDMLCEDLAHATEQLNMLT--EASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVE 1115
             DM  E+    TE  N+    +A ++    L+S   +L   +A      H L +  E  E
Sbjct: 419  NDMFHENAMLQTENNNLRVRIKAMQETVDALRSRITQLVSDQA-----NHVLARAGEGNE 473

Query: 1116 QKKNEYNFKMRQLEHV----MDSAAEDPQSPKT-------PPHFQ---THLAKLLETQEQ 1161
            +  N  +  ++++E +    ++S A +    K         P+F    T    +L + ++
Sbjct: 474  EISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKE 533

Query: 1162 EIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQ 1221
             IE    +K  LE L  K             R K+ +   E+     Q+  E+  + + +
Sbjct: 534  TIEIIDLAKKDLEKLKRKEK-----------RKKKSVAGKEDNTDTDQEKKEEKGVSERE 582

Query: 1222 LDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKI---VEEMLKMKADLEEVQSALY 1278
             ++++ ++     +H D ++ + E+E+ I    +  +     +E    +ADL  +   + 
Sbjct: 583  NNELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQADLANITCEIA 642

Query: 1279 NKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAE 1338
             K+     + +  +R QTL+ +  ++   L+ K+ +   ER++  Q +      VE  +E
Sbjct: 643  IKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNL----GSVESYSE 698

Query: 1339 ENGKLVGH------QNLHQKIQYVVRLKKENVRL-------AEETEKLRAENVFLKEKK 1384
            E  K V        Q +++++Q +   +KE+ RL        ++ +KL+ + + +K+ K
Sbjct: 699  EKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTK 757


>gi|4758648 kinesin family member 5B [Homo sapiens]
          Length = 963

 Score =  262 bits (669), Expect = 2e-69
 Identities = 260/933 (27%), Positives = 437/933 (46%), Gaps = 108/933 (11%)

Query: 68  KTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDN 127
           K + FD V    T+QE V+   AK IV+  + GYNGTIFAYGQT SGKT TM G      
Sbjct: 44  KPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPE 103

Query: 128 FSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAGLYL 187
                 G+IPR  + +F+ I    E       F  K S+ EIY ++I DLLD +   L +
Sbjct: 104 G----MGIIPRIVQDIFNYIYSMDENL----EFHIKVSYFEIYLDKIRDLLDVSKTNLSV 155

Query: 188 REHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESM 247
            E   +  +V G  E+ V S  E    +  G  NR VA T+MN  SSRSH++F I ++  
Sbjct: 156 HEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVK-- 213

Query: 248 EKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGN 307
           +++ +     +  L LVDLAGSE+   T AEG  L EA NIN+SLS LG VI+AL +   
Sbjct: 214 QENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE--- 270

Query: 308 GKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKA 367
               +V YRDSK+T +L+DSLGGN +T I+    P S    ET STL F QRAK IKN  
Sbjct: 271 -GSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTV 329

Query: 368 VVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKK 427
            VN +      Q + + ++ KE+   L +     E+ L R +          E +   ++
Sbjct: 330 CVNVEL--TAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRN--------GETVPIDEQ 379

Query: 428 SEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLE----KLHKESRGGFLP 483
            ++EK +L E  T  +D+TL  +K   +  +I  F + +  + E    KL+K+       
Sbjct: 380 FDKEKANL-EAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQL------ 432

Query: 484 EEQDRLLSELRNEIQTLREQ-IEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQ 542
           +++D  +++    ++ L+ Q ++    +A    +  +++ E  RL+            A+
Sbjct: 433 DDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQ------------AE 480

Query: 543 TIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEY 602
             A  E+    +  +E+   N   +  K+Q+        E L  +L Q    L +   E 
Sbjct: 481 NDASKEEVKEVLQALEELAVN---YDQKSQEVEDKTKEYELLSDELNQKSATLASIDAEL 537

Query: 603 EEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTP 662
           ++ KE+T  ++      + SL      L++L E   A    +V Q      E   +I   
Sbjct: 538 QKLKEMTNHQKKRAAEMMASL------LKDLAEIGIAVGNNDVKQ-----PEGTGMIDEE 586

Query: 663 TKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTV 722
               +L+   + K+  E+ +      Q           E    E N++  E         
Sbjct: 587 FTVARLY---ISKMKSEVKTMVKRCKQ----------LESTQTESNKKMEEN-------- 625

Query: 723 QEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFS--SERIDWTKQQEELLSQLN 780
           +++++A Q ++ + E K   L +++  +E    Q++E     SE +   + QE    +++
Sbjct: 626 EKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQE----KVH 681

Query: 781 VLEKQ-LQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERH 839
            +EK+ L + QT N+  ++    ++    +  K++SS++ E  +    + K    L +++
Sbjct: 682 EMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEA----KAKLITDLQDQN 737

Query: 840 MHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSD- 898
             + L+ + LR+E+EKL   KA  Q+    L E+   + D+  +  Q+ K   ET+  + 
Sbjct: 738 QKMMLEQERLRVEHEKL---KATDQEKSRKLHELTVMQ-DRREQARQDLKGLEETVAKEL 793

Query: 899 --LNNLMELLEAEKERNNKLSLQFEEDKENSS---KEILKVLEAVRQEKQKETAKCEQQM 953
             L+NL +L   +     K S + + D    S   K+ +  LE   ++  K   +  +  
Sbjct: 794 QTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDN 853

Query: 954 A----KVQKLEESLLATEKVISSLEKSRDSDKK 982
           A    ++ KLE+ L AT + + +LE +    K+
Sbjct: 854 ADLRCELPKLEKRLRATAERVKALESALKEAKE 886



 Score = 70.9 bits (172), Expect = 8e-12
 Identities = 112/524 (21%), Positives = 221/524 (42%), Gaps = 63/524 (12%)

Query: 718  ELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLS 777
            E R  +E+++ L  +LD+++ +  +  Q V+KL+      +EL +S R D    Q+ + +
Sbjct: 417  ERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRD----QDNMQA 472

Query: 778  QLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSE 837
            +LN L       Q +ND  K EV ++   L    +EL+    + S    ++ KE+  LS+
Sbjct: 473  ELNRL-------QAENDASKEEVKEVLQAL----EELAVNYDQKSQEVEDKTKEYELLSD 521

Query: 838  RHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQN--FKKENETL 895
                    L ++  E +KL E     +     +   +  ++ ++   + N   K+   T 
Sbjct: 522  ELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTG 581

Query: 896  KSDLNNLMELLEAEKERNN-----KLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCE 950
              D    +  L   K ++      K   Q E  +  S+K++        +E +KE A C+
Sbjct: 582  MIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKM--------EENEKELAACQ 633

Query: 951  ----QQMAKVQKLEESLLATEKVISSLEKSRD--SDKKVVADLMNQIQELRTSVCEKTET 1004
                Q  AK++ L E L   E+    LE+S D  S++ V      ++ E+      K +T
Sbjct: 634  LRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQT 693

Query: 1005 IDTLKQEL-------KDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIE 1057
             + +KQ +       ++ + K  S+L D  E++    K   D+ D  + + L      +E
Sbjct: 694  ANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKA---KLITDLQDQNQKMMLEQERLRVE 750

Query: 1058 RDMLCEDLAHATEQLNMLT-------EASKKHSGLLQSAQEELTK----KEALIQELQHK 1106
             + L       + +L+ LT       +A +   GL ++  +EL      ++  +Q+L  +
Sbjct: 751  HEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATR 810

Query: 1107 LNQKKEEVEQKKNEYNFKMRQLEHVMDSAAED-----PQSPKTPPHFQTHLAKLLETQEQ 1161
            + +K  E++      +   +Q    +++  E       Q  +     +  L KL +    
Sbjct: 811  V-KKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRA 869

Query: 1162 EIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLR 1205
              E  +A +++L+      + DR+    E+ R+KE +R     R
Sbjct: 870  TAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMAR 913



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 112/606 (18%), Positives = 249/606 (41%), Gaps = 59/606 (9%)

Query: 567  FSPKAQKEPCLFANTEKLKAQLLQIQTELNNS--KQEYEEFKE---LTRKRQLELESELQ 621
            ++    K   LF    K     + +  EL     K++YE+ KE   + R     LE+EL 
Sbjct: 307  YNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELN 366

Query: 622  SLQKAN-LNLENLLEATKACKR-----QEVSQLNKIHAETLKIITTPTKAYQLH-SRPVP 674
              +    + ++   +  KA        ++++  N   A  + +I   T A +      + 
Sbjct: 367  RWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIA 426

Query: 675  KLSPEMGSFGSLYTQNSSILDNDILNEPVPPEM--NEQAFEAISEELRTVQEQMSALQAK 732
            KL  ++        Q S ++      E +  +M   E+   +   +   +Q +++ LQA+
Sbjct: 427  KLYKQLDDKDEEINQQSQLV------EKLKTQMLDQEELLASTRRDQDNMQAELNRLQAE 480

Query: 733  LDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLN-------VLEKQ 785
             D  + +  ++ Q +++L  +  Q     S E  D TK+ E L  +LN        ++ +
Sbjct: 481  NDASKEEVKEVLQALEELAVNYDQK----SQEVEDKTKEYELLSDELNQKSATLASIDAE 536

Query: 786  LQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQ 845
            LQ+ +   +  K    ++   + S  K+L+ + +   +    Q +    + E     +L 
Sbjct: 537  LQKLKEMTNHQKKRAAEM---MASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLY 593

Query: 846  LDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMEL 905
            +  ++ E + +++    L+ +     + M+    +L+       +    +KS L   ++ 
Sbjct: 594  ISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKS-LTEYLQN 652

Query: 906  LEAEKERNNKLSLQFEEDKENSSKEIL------KVLEAVRQEKQKETAKCEQQMAKVQKL 959
            +E +K        Q EE  +  S+E++      KV E  ++   K     E + A  Q++
Sbjct: 653  VEQKKR-------QLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQI 705

Query: 960  EESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKY 1019
            +      +K ISSL    ++  K++ DL +Q Q++      + E +    ++LK  + + 
Sbjct: 706  QSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMML----EQERLRVEHEKLKATDQEK 761

Query: 1020 NSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNML---- 1075
            +  L +    +   ++   D+  L+ET+   + +    R +  +DLA   ++   +    
Sbjct: 762  SRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDD 821

Query: 1076 ---TEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVM 1132
               + A K+    L++  E+LTK    +      L  +  ++E++      +++ LE  +
Sbjct: 822  TGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESAL 881

Query: 1133 DSAAED 1138
              A E+
Sbjct: 882  KEAKEN 887



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 101/527 (19%), Positives = 209/527 (39%), Gaps = 77/527 (14%)

Query: 886  QNFKKENETLKSDLNNLMELLEAEKER-NNKLSLQFEE--DKENSSKEILKVLEAVRQEK 942
            + ++KE E  K  L N ++ LE E  R  N  ++  +E  DKE ++ E   V + +    
Sbjct: 342  KKYEKEKEKNKI-LRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTN 400

Query: 943  QK--------------ETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLM 988
             K              E  KCE+++AK                 L K  D   + +    
Sbjct: 401  DKPATAIGVIGNFTDAERRKCEEEIAK-----------------LYKQLDDKDEEINQQS 443

Query: 989  NQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLR 1048
              +++L+T + ++ E + + +++  ++  + N    + + S+  +K    ++L   E L 
Sbjct: 444  QLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVK----EVLQALEELA 499

Query: 1049 LRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLN 1108
                   +  D   +++   T++  +L++   + S  L S   EL K + +        +
Sbjct: 500  -------VNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTN------H 546

Query: 1109 QKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRA 1168
            QKK   E   +           V ++  + P+         T     +   + E++    
Sbjct: 547  QKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVK 606

Query: 1169 SKTSLEHLVTKLNEDREVKNAEI----LRMKEQLREMENLRLESQQLIEKNWLLQGQLDD 1224
                LE   T+ N+  E    E+    LR+ +   ++++L    Q + +K          
Sbjct: 607  RCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQK---------- 656

Query: 1225 IKRQKENS-DQNHPDNQQLKNEQE--ESIKERLAKSKIVEEMLKMKADLEEVQSALYNKE 1281
             KRQ E S D    +  QL+ +++  E  KE L K +   E+   +A  +++QS     +
Sbjct: 657  -KRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEV--KQAVEQQIQSHRETHQ 713

Query: 1282 MECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERER-TSQEMEMLRKQVECLAEEN 1340
             +   + DEVE    L +    + +++  + E +  E E+  + + E  RK  E    ++
Sbjct: 714  KQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQD 773

Query: 1341 GKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFLKEKKRSE 1387
             +    Q+L    + V +     ++      KL  +++  + KK +E
Sbjct: 774  RREQARQDLKGLEETVAK----ELQTLHNLRKLFVQDLATRVKKSAE 816


>gi|13699824 kinesin family member 11 [Homo sapiens]
          Length = 1056

 Score =  261 bits (666), Expect = 4e-69
 Identities = 320/1215 (26%), Positives = 529/1215 (43%), Gaps = 214/1215 (17%)

Query: 9    LRSVTNGQSNQPSNEGDAIKVFVRIRP--PAERSGSADGEQNLCLSVLSSTSLR---LHS 63
            + S  N  + +   +G  I+V VR RP   AER  SA      C  V    S+R   L  
Sbjct: 1    MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVE-CDPVRKEVSVRTGGLAD 59

Query: 64   NPEPKTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMG-- 121
                KT+TFD V    T Q  V+ +V   I++  + GYN TIFAYGQTG+GKTFTM G  
Sbjct: 60   KSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGER 119

Query: 122  -PSESDNFSHN-LRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLD 179
             P+E   +  + L G+IPR+   +F  +         G  F  K S +EIYNE+++DLL+
Sbjct: 120  SPNEEYTWEEDPLAGIIPRTLHQIFEKLTDN------GTEFSVKVSLLEIYNEELFDLLN 173

Query: 180  SAS-----AGLYLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESS 234
             +S       ++     K+GV + G  E  V +  E YQ+L  G   R  A+T MN  SS
Sbjct: 174  PSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSS 233

Query: 235  RSHAVFTITIESMEKS---NEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRS 291
            RSH+VF++TI   E +    E+V I    LNLVDLAGSE    + A   R +EAGNIN+S
Sbjct: 234  RSHSVFSVTIHMKETTIDGEELVKI--GKLNLVDLAGSENIGRSGAVDKRAREAGNINQS 291

Query: 292  LSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETL 351
            L  LG+VITALV+    +  HV YR+SKLT +L+DSLGG  +T+IIA + P S    ETL
Sbjct: 292  LLTLGRVITALVE----RTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETL 347

Query: 352  STLNFAQRAKLIKNKAVVNE--DTQGNVSQLQAEVKRLKEQLA---ELASGQTPPESFLT 406
            STL +A RAK I NK  VN+    +  + +   E++RLK  LA   E        E+F  
Sbjct: 348  STLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRV 407

Query: 407  RDKKKTNYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQ 466
               K T                E++   LIEK+  +E+   +  +    NK         
Sbjct: 408  MSGKLT--------------VQEEQIVELIEKIGAVEEELNRVTELFMDNK--------- 444

Query: 467  IIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRR 526
                              E D+  S+L+N+ Q L    +H             L+E   +
Sbjct: 445  -----------------NELDQCKSDLQNKTQELETTQKH-------------LQETKLQ 474

Query: 527  LRLLEPVKRAQEMDAQTIAKLEKAFSE-ISGMEKSDKNQQGFSPKAQKEPCLFANTEKLK 585
            L   E +  A E    T  KL  A S+ ++ +E++ K+  G   K  ++  +  +  + +
Sbjct: 475  LVKEEYITSALE---STEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQ 531

Query: 586  AQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEV 645
                +    L N+ +E  +     +K  LE+   L           NLL ++       V
Sbjct: 532  DIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTL---------FGNLLSSS-------V 575

Query: 646  SQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPP 705
            S L+ I    L  +T+  +    H                      S + N IL E    
Sbjct: 576  SALDTITTVALGSLTSIPENVSTH---------------------VSQIFNMILKE---- 610

Query: 706  EMNEQAFEAISEELRTV-QEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSE 764
                   ++++ E +TV QE ++ L  K D      + L   V  +   ++Q++ +F + 
Sbjct: 611  -------QSLAAESKTVLQELINVL--KTDLLSSLEMILSPTVVSILKINSQLKHIFKTS 661

Query: 765  RIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLR----VVLHSADKELSSVKLE 820
                       L+  + +E Q +E       L + +H+L+      L  + K+  ++  +
Sbjct: 662  -----------LTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTED 710

Query: 821  YSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQ 880
              + K    +E  KL      + L  +      EK    +  L    +N+Q+  K  +++
Sbjct: 711  LKTIKQTHSQELCKL------MNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNK 764

Query: 881  LSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQ 940
            ++ + Q F  +++    +L N            N+   +  E+    S ++   LE + Q
Sbjct: 765  MTFHSQKFCADSDGFSQELRNF-----------NQEGTKLVEESVKHSDKLNGNLEKISQ 813

Query: 941  EKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCE 1000
            E ++   +CE    +      ++  +E+ +SSL +            ++ + E+ +  CE
Sbjct: 814  ETEQ---RCESLNTR------TVYFSEQWVSSLNEREQE--------LHNLLEVVSQCCE 856

Query: 1001 KTETIDTLKQE-LKDINCKYNSALVDR---EESRVLIKKQEVDILDLKETLRLRI--LSE 1054
             + +  T K +  K  + K ++  +D+   +E +++ +      L+L ET+++ +  L+ 
Sbjct: 857  ASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQN-----LELNETIKIGLTKLNC 911

Query: 1055 DIERDMLCEDLAHATEQ-LNMLTEASKKHSGLLQSAQEELTKKE-ALIQELQHKLNQKKE 1112
             +E+D+  +     T Q  + L  ++   +   +   ++L +K+  L+  L    N K+E
Sbjct: 912  FLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEE 971

Query: 1113 EV------EQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDG 1166
             +      E    +Y  +    E  +D A  D  S    P FQ   +   + + + I   
Sbjct: 972  TIPDVDVEEAVLGQYTEEPLSQEPSVD-AGVDCSSIGGVPFFQHKKSHGKDKENRGINTL 1030

Query: 1167 RASKT--SLEHLVTK 1179
              SK   + EHLVTK
Sbjct: 1031 ERSKVEETTEHLVTK 1045



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 133/639 (20%), Positives = 246/639 (38%), Gaps = 111/639 (17%)

Query: 773  EELLSQLNVLEKQLQETQTKNDFLKSEVHDL---RVVLHSADKELSSVKLEYSSFKTNQE 829
            EE LS L    +       KN   K EV+     + ++    +E+  +K + ++ +   E
Sbjct: 344  EETLSTLEYAHR------AKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAR---E 394

Query: 830  KEFNKLSERHMHVQLQLDNLRLENEK---LLESKACLQDSYDNLQEIM---KFEIDQLSR 883
            K    +SE +  V      L ++ E+   L+E    +++  + + E+    K E+DQ   
Sbjct: 395  KNGVYISEENFRVMS--GKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKS 452

Query: 884  NLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDK-ENSSKEILKVLEAVRQEK 942
            +LQN  +E ET +  L      L+  KE     +L+  E+K  +++ ++L  +E      
Sbjct: 453  DLQNKTQELETTQKHLQETK--LQLVKEEYITSALESTEEKLHDAASKLLNTVE------ 504

Query: 943  QKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKT 1002
              ET K       V  L   L   + V     +++D   K +  L N ++EL        
Sbjct: 505  --ETTK------DVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEEL-------- 548

Query: 1003 ETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLC 1062
                     +KD + K  + L   +     +    V  LD   T+ L  L+   E     
Sbjct: 549  ---------IKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVS-- 597

Query: 1063 EDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYN 1122
                H ++  NM+ +           A E  T  + LI  L+  L    E +        
Sbjct: 598  ---THVSQIFNMILKEQ-------SLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSI 647

Query: 1123 FKMR-QLEHVMDSAAE-----DPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHL 1176
             K+  QL+H+  ++       + Q  +           L E QE  I     S+    +L
Sbjct: 648  LKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNL 707

Query: 1177 VTKLNEDREVKNAEILRMKEQLRE--------MENLRLESQQLIEKNWLLQGQLDDIKRQ 1228
               L   ++  + E+ ++     E         EN++     + E   + Q   D + + 
Sbjct: 708  TEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQEN--IQQKSKDIVNKM 765

Query: 1229 KENSDQNHPD----NQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMEC 1284
              +S +   D    +Q+L+N  +E        +K+VEE +K         S   N  +E 
Sbjct: 766  TFHSQKFCADSDGFSQELRNFNQEG-------TKLVEESVK--------HSDKLNGNLEK 810

Query: 1285 LRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEE-NGKL 1343
            +    E +R ++L ++     EQ  S L E  +E       +E++ +  E  + +   K 
Sbjct: 811  ISQETE-QRCESLNTRTVYFSEQWVSSLNEREQELHNL---LEVVSQCCEASSSDITEKS 866

Query: 1344 VGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFLKE 1382
             G +  H+K Q+ + L +  +    + +KL A+N+ L E
Sbjct: 867  DGRKAAHEK-QHNIFLDQMTI----DEDKLIAQNLELNE 900


>gi|157738629 kinesin family member 13A isoform d [Homo sapiens]
          Length = 1749

 Score =  256 bits (655), Expect = 8e-68
 Identities = 175/450 (38%), Positives = 258/450 (57%), Gaps = 45/450 (10%)

Query: 27  IKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPE---------PKTFTFDH--- 74
           +KV VR+RP   R    + +   C+  +      LH  P          PK F FD+   
Sbjct: 6   VKVAVRVRPMNRRELELNTK---CVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFW 62

Query: 75  -VADVDTT----QESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFS 129
            + + +TT    QE VF  + + I+E    GYN  IFAYGQTGSGK+F+MMG +E     
Sbjct: 63  SMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQ---- 118

Query: 130 HNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASA--GLYL 187
               G+IPR    LF  I  E+ ++   ++F  + S++EIYNE++ DLLD   +   L +
Sbjct: 119 ---LGLIPRLCCALFKRISLEQNES---QTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKV 172

Query: 188 REHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTI----T 243
           REH   G +V G  +  VTS  +   ++S G ++R VA+T+MN ESSRSHAVF I    T
Sbjct: 173 REHKVLGPYVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQT 232

Query: 244 IESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALV 303
           +  ++  N     + S ++LVDLAGSER   T A G RLKE  NIN+SL+ LG VI++L 
Sbjct: 233 LYDLQSGNS--GEKVSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLA 290

Query: 304 D--VGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAK 361
           D   G GK + V YRDS LT+LL+D+LGGN++T++IA + P +  + ETLSTL +A RAK
Sbjct: 291 DQAAGKGKSKFVPYRDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAK 350

Query: 362 LIKNKAVVNEDTQGNV-SQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQE 420
            I N AVVNED    V  +L+ EV++L+EQL++  + + P      ++K + +     + 
Sbjct: 351 RIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAEAMKAPE----LKEKLEESEKLIKEL 406

Query: 421 AMLFFKKSEQEKKSLIEKVTQLEDLTLKKE 450
            + + +K  + ++   E+  QLE + +  E
Sbjct: 407 TVTWEEKLRKTEEIAQERQRQLESMGISLE 436


>gi|157738627 kinesin family member 13A isoform c [Homo sapiens]
          Length = 1757

 Score =  256 bits (655), Expect = 8e-68
 Identities = 175/450 (38%), Positives = 258/450 (57%), Gaps = 45/450 (10%)

Query: 27  IKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPE---------PKTFTFDH--- 74
           +KV VR+RP   R    + +   C+  +      LH  P          PK F FD+   
Sbjct: 6   VKVAVRVRPMNRRELELNTK---CVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFW 62

Query: 75  -VADVDTT----QESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFS 129
            + + +TT    QE VF  + + I+E    GYN  IFAYGQTGSGK+F+MMG +E     
Sbjct: 63  SMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQ---- 118

Query: 130 HNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASA--GLYL 187
               G+IPR    LF  I  E+ ++   ++F  + S++EIYNE++ DLLD   +   L +
Sbjct: 119 ---LGLIPRLCCALFKRISLEQNES---QTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKV 172

Query: 188 REHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTI----T 243
           REH   G +V G  +  VTS  +   ++S G ++R VA+T+MN ESSRSHAVF I    T
Sbjct: 173 REHKVLGPYVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQT 232

Query: 244 IESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALV 303
           +  ++  N     + S ++LVDLAGSER   T A G RLKE  NIN+SL+ LG VI++L 
Sbjct: 233 LYDLQSGNS--GEKVSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLA 290

Query: 304 D--VGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAK 361
           D   G GK + V YRDS LT+LL+D+LGGN++T++IA + P +  + ETLSTL +A RAK
Sbjct: 291 DQAAGKGKSKFVPYRDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAK 350

Query: 362 LIKNKAVVNEDTQGNV-SQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQE 420
            I N AVVNED    V  +L+ EV++L+EQL++  + + P      ++K + +     + 
Sbjct: 351 RIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAEAMKAPE----LKEKLEESEKLIKEL 406

Query: 421 AMLFFKKSEQEKKSLIEKVTQLEDLTLKKE 450
            + + +K  + ++   E+  QLE + +  E
Sbjct: 407 TVTWEEKLRKTEEIAQERQRQLESMGISLE 436


>gi|157738625 kinesin family member 13A isoform b [Homo sapiens]
          Length = 1770

 Score =  256 bits (655), Expect = 8e-68
 Identities = 175/450 (38%), Positives = 258/450 (57%), Gaps = 45/450 (10%)

Query: 27  IKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPE---------PKTFTFDH--- 74
           +KV VR+RP   R    + +   C+  +      LH  P          PK F FD+   
Sbjct: 6   VKVAVRVRPMNRRELELNTK---CVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFW 62

Query: 75  -VADVDTT----QESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFS 129
            + + +TT    QE VF  + + I+E    GYN  IFAYGQTGSGK+F+MMG +E     
Sbjct: 63  SMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQ---- 118

Query: 130 HNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASA--GLYL 187
               G+IPR    LF  I  E+ ++   ++F  + S++EIYNE++ DLLD   +   L +
Sbjct: 119 ---LGLIPRLCCALFKRISLEQNES---QTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKV 172

Query: 188 REHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTI----T 243
           REH   G +V G  +  VTS  +   ++S G ++R VA+T+MN ESSRSHAVF I    T
Sbjct: 173 REHKVLGPYVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQT 232

Query: 244 IESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALV 303
           +  ++  N     + S ++LVDLAGSER   T A G RLKE  NIN+SL+ LG VI++L 
Sbjct: 233 LYDLQSGNS--GEKVSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLA 290

Query: 304 D--VGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAK 361
           D   G GK + V YRDS LT+LL+D+LGGN++T++IA + P +  + ETLSTL +A RAK
Sbjct: 291 DQAAGKGKSKFVPYRDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAK 350

Query: 362 LIKNKAVVNEDTQGNV-SQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQE 420
            I N AVVNED    V  +L+ EV++L+EQL++  + + P      ++K + +     + 
Sbjct: 351 RIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAEAMKAPE----LKEKLEESEKLIKEL 406

Query: 421 AMLFFKKSEQEKKSLIEKVTQLEDLTLKKE 450
            + + +K  + ++   E+  QLE + +  E
Sbjct: 407 TVTWEEKLRKTEEIAQERQRQLESMGISLE 436


>gi|157738621 kinesin family member 13A isoform a [Homo sapiens]
          Length = 1805

 Score =  256 bits (655), Expect = 8e-68
 Identities = 175/450 (38%), Positives = 258/450 (57%), Gaps = 45/450 (10%)

Query: 27  IKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPE---------PKTFTFDH--- 74
           +KV VR+RP   R    + +   C+  +      LH  P          PK F FD+   
Sbjct: 6   VKVAVRVRPMNRRELELNTK---CVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFW 62

Query: 75  -VADVDTT----QESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFS 129
            + + +TT    QE VF  + + I+E    GYN  IFAYGQTGSGK+F+MMG +E     
Sbjct: 63  SMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQ---- 118

Query: 130 HNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASA--GLYL 187
               G+IPR    LF  I  E+ ++   ++F  + S++EIYNE++ DLLD   +   L +
Sbjct: 119 ---LGLIPRLCCALFKRISLEQNES---QTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKV 172

Query: 188 REHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTI----T 243
           REH   G +V G  +  VTS  +   ++S G ++R VA+T+MN ESSRSHAVF I    T
Sbjct: 173 REHKVLGPYVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQT 232

Query: 244 IESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALV 303
           +  ++  N     + S ++LVDLAGSER   T A G RLKE  NIN+SL+ LG VI++L 
Sbjct: 233 LYDLQSGNS--GEKVSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLA 290

Query: 304 D--VGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAK 361
           D   G GK + V YRDS LT+LL+D+LGGN++T++IA + P +  + ETLSTL +A RAK
Sbjct: 291 DQAAGKGKSKFVPYRDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAK 350

Query: 362 LIKNKAVVNEDTQGNV-SQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQE 420
            I N AVVNED    V  +L+ EV++L+EQL++  + + P      ++K + +     + 
Sbjct: 351 RIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAEAMKAPE----LKEKLEESEKLIKEL 406

Query: 421 AMLFFKKSEQEKKSLIEKVTQLEDLTLKKE 450
            + + +K  + ++   E+  QLE + +  E
Sbjct: 407 TVTWEEKLRKTEEIAQERQRQLESMGISLE 436


>gi|46852172 kinesin family member 13B [Homo sapiens]
          Length = 1826

 Score =  256 bits (655), Expect = 8e-68
 Identities = 174/445 (39%), Positives = 257/445 (57%), Gaps = 37/445 (8%)

Query: 24  GDA-IKVFVRIRPPAERSGS------ADGEQN-LCLSVLSSTSLRLHSNPEPKTFTFDH- 74
           GD+ +KV VRIRP   R          D + N + L+ +++   +  +  +PK F +DH 
Sbjct: 2   GDSKVKVAVRIRPMNRRETDLHTKCVVDVDANKVILNPVNTNLSKGDARGQPKVFAYDHC 61

Query: 75  -------VADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDN 127
                  V +    Q+ VF  + ++I+++   GYN  IFAYGQTGSGK++TMMG ++   
Sbjct: 62  FWSMDESVKEKYAGQDIVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQP- 120

Query: 128 FSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAG--L 185
                 G+IPR    LF    +E+ +    +SF  + S++EIYNE++ DLLD   +   L
Sbjct: 121 ------GLIPRLCSGLFERTQKEENEE---QSFKVEVSYMEIYNEKVRDLLDPKGSRQTL 171

Query: 186 YLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIE 245
            +REH   G +V G  +  VTS  +   ++S G ++R VA+T+MN ESSRSHAVF IT+ 
Sbjct: 172 KVREHSVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLT 231

Query: 246 SM--EKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALV 303
               +  +     +   L+LVDLAGSER   T A G RLKE  NIN+SL+ LG VI+AL 
Sbjct: 232 HTLYDVKSGTSGEKVGKLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTLGLVISALA 291

Query: 304 D--VGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAK 361
           D   G  K + V YRDS LT+LL+DSLGGN+KTA++A V P +  + ETLSTL +A RAK
Sbjct: 292 DQSAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAK 351

Query: 362 LIKNKAVVNEDTQGN-VSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQE 420
            I N AVVNED     +  L+ EV++L+EQL +  + ++P      +D+ + +     + 
Sbjct: 352 HIVNHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMKSPE----LKDRLEESEKLIQEM 407

Query: 421 AMLFFKKSEQEKKSLIEKVTQLEDL 445
            + + +K  + ++   E+  QLE L
Sbjct: 408 TVTWEEKLRKTEEIAQERQKQLESL 432


>gi|41393563 kinesin family member 1B isoform b [Homo sapiens]
          Length = 1770

 Score =  254 bits (648), Expect = 5e-67
 Identities = 236/785 (30%), Positives = 374/785 (47%), Gaps = 106/785 (13%)

Query: 24  GDAIKVFVRIRPPAERSGSADGEQNLCLSVL--SSTSLRLHSNPE--PKTFTFD-----H 74
           G ++KV VR+RP   R  S + +   C+  +  +STS+    NP+  PK+F+FD     H
Sbjct: 3   GASVKVAVRVRPFNSRETSKESK---CIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSH 59

Query: 75  VADVD---TTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHN 131
            +  D    +Q  V+  + K ++     GYN  IFAYGQTG+GK++TMMG  E       
Sbjct: 60  TSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQ---- 115

Query: 132 LRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAG-LYLREH 190
             G+IP+  E LF  I+   +      S+  + S++EIY E++ DLL+  + G L +REH
Sbjct: 116 -AGIIPQLCEELFEKIN---DNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREH 171

Query: 191 IKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKS 250
              G +V    +  VTS  +   ++  G + R VA+T+MN  SSRSHAVFTI     +  
Sbjct: 172 PLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHD 231

Query: 251 NEIVNIRT---SLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGN 307
           NE  N+ T   S ++LVDLAGSER   T A+G RLKE  NIN+SL+ LG+VI+AL +V  
Sbjct: 232 NE-TNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSK 290

Query: 308 GKQR--HVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKN 365
            K++   + YRDS LT+LLR++LGGN++TA++A + P    + ETLSTL +A RAK IK 
Sbjct: 291 KKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKC 350

Query: 366 KAVVNEDTQGN-VSQLQAEVKRLKEQL----------AELASGQTPPESFLTRDKKKTNY 414
            AV+NED     V +L+ EV RLK+ L            + S  + P S     +     
Sbjct: 351 NAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLSSQVGLTS 410

Query: 415 MEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLH 474
           +   QE ++     E+  + L E    + +L    E+ ++  + I   RE  +  +    
Sbjct: 411 VTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAI 470

Query: 475 KE---SRGGFLPEE--------QDRLLSE-----LRNEI----QTLREQIEHHPRVAKYA 514
           +E   + G F P++        +D L+SE     +++ I    Q   E+ +       + 
Sbjct: 471 REDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHI 530

Query: 515 MENHSLREENRR-----LRLLEPVKRAQE-MDAQTIA---KLEKAFSEISGMEKSDKNQQ 565
            E H +    R      +  LEP +R++  ++ + ++   +L      I G     +   
Sbjct: 531 KEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNH 590

Query: 566 GFSPKAQKEPC------------LFANTEKLKAQLLQIQTELNNS--------KQEYEEF 605
               +A++E               FA  E L+ Q + ++ E+           K+E EE 
Sbjct: 591 PEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEA 650

Query: 606 KELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKA 665
             L  +++L+ ES+LQ+LQK         E T+  + +E     +   E  +      K+
Sbjct: 651 DLLLEQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKS 710

Query: 666 YQLHS------------RPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFE 713
           +Q  S            +    +S E+        Q   +L  D L  P+PPE+     E
Sbjct: 711 HQFTSLRDLLWGNAVYLKEANAISVEL----KKKVQFQFVLLTDTLYSPLPPELLPTEME 766

Query: 714 AISEE 718
              E+
Sbjct: 767 KTHED 771


>gi|19924175 axonal transport of synaptic vesicles [Homo sapiens]
          Length = 1690

 Score =  253 bits (645), Expect = 1e-66
 Identities = 216/687 (31%), Positives = 341/687 (49%), Gaps = 98/687 (14%)

Query: 24  GDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPE-PKTFTFD-----HVAD 77
           G ++KV VR+RP   R  S D +  + +S  ++T +      E PK+F+FD     H + 
Sbjct: 3   GASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSP 62

Query: 78  VD---TTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRG 134
            D    +Q+ V+  + + +++    GYN  IFAYGQTG+GK++TMMG  E D      +G
Sbjct: 63  EDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQ-----QG 117

Query: 135 VIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAG-LYLREHIKK 193
           +IP+  E LFS I+   +      S+  + S++EIY E++ DLL+  + G L +REH   
Sbjct: 118 IIPQLCEDLFSRIN---DTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLL 174

Query: 194 GVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTI--TIESMEKSN 251
           G +V    +  VTS  +   ++  G + R VA+T+MN  SSRSHAVF I  T +  +   
Sbjct: 175 GPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAET 234

Query: 252 EIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQR 311
            I   + S ++LVDLAGSER   T A+G RLKE  NIN+SL+ LG+VI+AL ++ +G  +
Sbjct: 235 NITTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNK 294

Query: 312 H--------VCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLI 363
           +        + YRDS LT+LLR++LGGN++TA++A + P    + ETLSTL +A RAK I
Sbjct: 295 NKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQI 354

Query: 364 KNKAVVNEDTQGN-VSQLQAEVKRLKEQLAELASGQ----------TPPESFLTRDKKKT 412
           +  AV+NED     + +L+ EV RL++ L     G             P S L+    + 
Sbjct: 355 RCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRA 414

Query: 413 NYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEK 472
             +    E +LF   SE+  + L E    + +L    E+ ++  + I   RE  +  +  
Sbjct: 415 ASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGV 474

Query: 473 LHKE---SRGGFLPEE--------QDRLLSE-----LRNEIQTLREQIEHHPRVAKYAME 516
             +E   + G F P++        +D L+SE     +++ I   R   E   R     + 
Sbjct: 475 AMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGI--TRVGREDGERRQDIVLS 532

Query: 517 NHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISG----------------MEKS 560
            H ++EE+   R      R       T+   E A + ++G                M KS
Sbjct: 533 GHFIKEEHCVFR---SDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKS 589

Query: 561 DKNQQGFSPKAQKE----PC----------LFANTEKLKAQLLQIQTELNNSKQEY---- 602
              +     +A++E    PC           FA  E L+ Q + ++ E+    QE     
Sbjct: 590 HVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQY 649

Query: 603 ----EEFKELTRKRQLELESELQSLQK 625
               EE   L  +++L+ ES+L++LQK
Sbjct: 650 RREREEATYLLEQQRLDYESKLEALQK 676


>gi|41393559 kinesin family member 1B isoform alpha [Homo sapiens]
          Length = 1153

 Score =  245 bits (626), Expect = 2e-64
 Identities = 180/500 (36%), Positives = 271/500 (54%), Gaps = 44/500 (8%)

Query: 24  GDAIKVFVRIRPPAERSGSADGEQNLCLSVL--SSTSLRLHSNPE--PKTFTFD-----H 74
           G ++KV VR+RP   R  S + +   C+  +  +STS+    NP+  PK+F+FD     H
Sbjct: 3   GASVKVAVRVRPFNSRETSKESK---CIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSH 59

Query: 75  VADVD---TTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHN 131
            +  D    +Q  V+  + K ++     GYN  IFAYGQTG+GK++TMMG  E       
Sbjct: 60  TSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQ---- 115

Query: 132 LRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAG-LYLREH 190
             G+IP+  E LF  I+   +      S+  + S++EIY E++ DLL+  + G L +REH
Sbjct: 116 -AGIIPQLCEELFEKIN---DNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREH 171

Query: 191 IKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKS 250
              G +V    +  VTS  +   ++  G + R VA+T+MN  SSRSHAVFTI     +  
Sbjct: 172 PLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHD 231

Query: 251 NEIVNIRT---SLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGN 307
           NE  N+ T   S ++LVDLAGSER   T A+G RLKE  NIN+SL+ LG+VI+AL +V  
Sbjct: 232 NE-TNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSK 290

Query: 308 GKQR--HVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKN 365
            K++   + YRDS LT+LLR++LGGN++TA++A + P    + ETLSTL +A RAK IK 
Sbjct: 291 KKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKC 350

Query: 366 KAVVNEDTQGN-VSQLQAEVKRLKEQL----------AELASGQTPPESFLTRDKKKTNY 414
            AV+NED     V +L+ EV RLK+ L            + S  + P S     +     
Sbjct: 351 NAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLSSQVGLTS 410

Query: 415 MEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLH 474
           +   QE ++     E+  + L E    + +L    E+ ++  + I   RE  +  +    
Sbjct: 411 VTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAI 470

Query: 475 KE---SRGGFLPEEQDRLLS 491
           +E   + G F P++   L++
Sbjct: 471 REDGGTLGVFSPKKTPHLVN 490



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 78/333 (23%), Positives = 151/333 (45%), Gaps = 33/333 (9%)

Query: 903  MELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETA------KCEQQMAKV 956
            +++ +  ++R  ++ + ++++KE +      +LE  R +   ++        CE+    +
Sbjct: 626  IDMKQEMEKRLQEMEILYKKEKEEADL----LLEQQRLDADSDSGDDSDKRSCEESWKLI 681

Query: 957  QKLEESLLATEKVISSLEKSR--DSDKKVVADLMNQI-QELRTSVCEKTETIDTLK-QEL 1012
              L E L    K+ + ++K     S KK     M QI Q  R S   K  TI  LK Q +
Sbjct: 682  TSLREKL-PPSKLQTIVKKCGLPSSGKKREPIKMYQIPQRRRLSKDSKWVTISDLKIQAV 740

Query: 1013 KDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQL 1072
            K+I C Y  AL D   SR  I  + + I+ +KE   +    +  ERD          + +
Sbjct: 741  KEI-C-YEVALNDFRHSRQEI--EALAIVKMKELCAMYGKKDPNERDSWRAVARDVWDTV 796

Query: 1073 NMLTE------ASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMR 1126
             +  E      A+ K S  +   +  + K E ++QE++ + N K EE++  +N    KM 
Sbjct: 797  GVGDEKIEDVMATGKGSTDVDDLKVHIDKLEDILQEVKKQNNMKDEEIKVLRN----KML 852

Query: 1127 QLEHVMD-SAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKL-NEDR 1184
            ++E V+    +++ +SP +    +   A +  T E  +  G   + + E  V++L N D 
Sbjct: 853  KMEKVLPLIGSQEQKSPGSHKAKEPVGAGVSSTSENNVSKGDNGELAKEERVSQLMNGDP 912

Query: 1185 EVKNAEILRMKEQLREMENLRLE--SQQLIEKN 1215
              +   +  M+++    +NL+ +  ++QL  +N
Sbjct: 913  AFRRGRLRWMRQEQIRFKNLQQQEITKQLRRQN 945


>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
          Length = 1780

 Score =  244 bits (624), Expect = 3e-64
 Identities = 341/1552 (21%), Positives = 649/1552 (41%), Gaps = 261/1552 (16%)

Query: 25   DAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLH-------------SNPEPKTFT 71
            D ++V +RIRP  +     + E   C+ +L S ++ L              S    + F+
Sbjct: 57   DYLQVCLRIRPFTQSEKELESEG--CVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFS 114

Query: 72   FDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHN 131
            F  V    TTQ+  F       V+  + G +  IF YG T SGKT+T  G  E+      
Sbjct: 115  FSKVFGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPR 174

Query: 132  LRGVI----------------PRSFEYLFSLIDREKEKAGAGKSFLCK------------ 163
               V+                 RS EYL    ++EKE+  A KS L +            
Sbjct: 175  TLNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEI-ASKSALLRQIKEVTVHNDSD 233

Query: 164  ---------------------------------------CSFIEIYNEQIYDLLDSASAG 184
                                                    SF EIYNE IYDL    S+ 
Sbjct: 234  DTLYGSLTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSK 293

Query: 185  LYLREHIK-----KGVFVVGAVEQV-VTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHA 238
               R+ ++     KG   +  ++ + V+ + EAY++L  G +++ VA T +N  SSRSH+
Sbjct: 294  FQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHS 353

Query: 239  VFTITIESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQV 298
            +FT+ I  +E S     IR S L+L DLAGSER   T  EG RL+E GNIN SL  LG+ 
Sbjct: 354  IFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKC 413

Query: 299  ITALVDVGNGK-QRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFA 357
            I  L +    K Q+HV +R+SKLT   +    G  K  +I N+      + ETL+ L F+
Sbjct: 414  INVLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFS 473

Query: 358  QRAKLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEY 417
                 I  K  V +    +  +L   VK  ++      S  +   S +   K+ T   E 
Sbjct: 474  ----AIAQKVCVPDTLNSSQEKLFGPVKSSQD-----VSLDSNSNSKILNVKRATISWEN 524

Query: 418  FQEAMLFFKKSEQEKKSLIEKVTQLED--------LTLKKEKFIQSNKMIVKFREDQIIR 469
              E ++       E + L+E++   E+        L    +K ++ NK  +   E +  +
Sbjct: 525  SLEDLM-------EDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKR--K 575

Query: 470  LEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRL 529
            L  L ++ +   + E++++L  E +     +RE+      V +   +  + RE + +  L
Sbjct: 576  LLDLIEDLKKKLINEKKEKLTLEFK-----IREE------VTQEFTQYWAQREADFKETL 624

Query: 530  LEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLL 589
            L+  +  +E   + +A  +    +    E++ K+    + K + E      T  L+ +  
Sbjct: 625  LQEREILEENAERRLAIFKDLVGKCDTREEAAKDI--CATKVETEEA----TACLELKFN 678

Query: 590  QIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKAN---------------------- 627
            QI+ EL  +K E  + KE  +KR+ E +S +Q L+ +N                      
Sbjct: 679  QIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKED 738

Query: 628  -----LNLENLLEATKACK-RQEVSQL---NKIHAETLKIITTPTKA------YQLHSRP 672
                  NL++ +E T  C  + + S L   NK+       +   +K+       +++   
Sbjct: 739  TINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENE 798

Query: 673  VPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAK 732
            + +  P     GS++  +S+I ++   +E V P + E       E++R +QE    L+A 
Sbjct: 799  LQQDEPP-AKKGSIHV-SSAITEDQKKSEEVRPNIAE------IEDIRVLQENNEGLRAF 850

Query: 733  L--DEEEHKNLKLQQ-HVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQET 789
            L   E E KN K ++  ++K   H  Q   L   + +  +K+ +++ S  ++   +L   
Sbjct: 851  LLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQ 910

Query: 790  QTKNDFLKSEV----HDLRVVLHSADKELSSVKLEYSSF-------KTNQEKEFNKLSER 838
            ++KN   + ++    +++     S    +S +KL ++           +Q    + L+ R
Sbjct: 911  KSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLR 970

Query: 839  HMHVQLQLDNL------RLENEKLLESKA--------CLQDSYDNLQEIMKFEIDQLSRN 884
             +    + DNL       L N+ L+  +           ++S+ +  E +  E  ++ + 
Sbjct: 971  DLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKA 1030

Query: 885  LQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQK 944
                  + E L+  +  L   ++  K+ NN+L  +  +++++  KE   +++ +++E Q+
Sbjct: 1031 SSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQE 1090

Query: 945  ETAKCEQQM---------------------AKVQKLEESLLATEKVISSLEKSRDSDKKV 983
            +    + Q+                     AK+++L E++L T+KV  S     + D   
Sbjct: 1091 KNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKEL-ETILETQKVECSHSAKLEQD--- 1146

Query: 984  VADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDL 1043
            + +  + I +L  ++ E  E +    +  KD+N K    L  +EE    I +   ++ D+
Sbjct: 1147 ILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVK---ELKLKEE----ITQLTNNLQDM 1199

Query: 1044 KETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQEL 1103
            K  L+L+   E+  R           ++   L E     S   Q+ + +L +KE    +L
Sbjct: 1200 KHLLQLKEEEEETNR-----------QETEKLKEELSASSARTQNLKADLQRKEEDYADL 1248

Query: 1104 QHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEI 1163
            + KL   K++++Q + E +  MR  + ++     + +  K     +  + +    Q +E 
Sbjct: 1249 KEKLTDAKKQIKQVQKEVSV-MRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQ 1307

Query: 1164 EDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIE-KNWLLQGQL 1222
             + +  + +++    +  +D  VK   I  M+  L E E  ++E  Q++E K   ++   
Sbjct: 1308 LNNQKVEEAIQQ-YERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLA 1366

Query: 1223 DDIKRQKENSDQNHPDNQQLKNEQEESIKERLAK-SKIVEEMLKMKADLEEVQSALYNKE 1281
             ++++ KE  +     N Q  N++ E+  + L K + + +E+ + +      +     ++
Sbjct: 1367 TELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEK 1426

Query: 1282 MECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENG 1341
            M  +    E E  +  E K + E    R +  +   E E  + ++      ++   EE  
Sbjct: 1427 MMLITQAKEAENIRNKEMKKYAED---RERFFKQQNEMEILTAQLTEKDSDLQKWREERD 1483

Query: 1342 KLVGHQNLHQKIQYVVRLKKEN-----VRLAEETEKLRAENVFLKEKKRSES 1388
            +LV    +  K      ++K+N      R+  ET K+  + + +K K+ S +
Sbjct: 1484 QLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSA 1535


>gi|40254834 kinesin family member 1C [Homo sapiens]
          Length = 1103

 Score =  241 bits (615), Expect = 4e-63
 Identities = 157/386 (40%), Positives = 230/386 (59%), Gaps = 29/386 (7%)

Query: 24  GDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRL----HSNPEPKTFTFD-----H 74
           G ++KV VR+RP   R  S D +   C+  +   +  +     S   PK+FTFD     H
Sbjct: 3   GASVKVAVRVRPFNARETSQDAK---CVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSH 59

Query: 75  VADVD---TTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHN 131
            +  D    +Q+ V+  + + ++     GYN  IFAYGQTG+GK++TMMG  E       
Sbjct: 60  TSTEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQ---- 115

Query: 132 LRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAG-LYLREH 190
            +G++P+  E LFS   R  E   A  S+  + S++EIY E++ DLL+  S G L +REH
Sbjct: 116 -QGIVPQLCEDLFS---RVSENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREH 171

Query: 191 IKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTI--TIESME 248
              G +V    +  VTS A+   ++  G + R VA+T+MN  SSRSHAVFTI  T    +
Sbjct: 172 PILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHD 231

Query: 249 KSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNG 308
           +   + + + S ++LVDLAGSER   + A GMRLKE  NIN+SL+ LG+VI+AL D+ + 
Sbjct: 232 QLTGLDSEKVSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADMQSK 291

Query: 309 KQRH--VCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNK 366
           K++   + YRDS LT+LL+++LGGN++TA+IA + P    + ETLSTL +A R K I+  
Sbjct: 292 KRKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCN 351

Query: 367 AVVNEDTQGN-VSQLQAEVKRLKEQL 391
           A++NED     + +LQ EV RL+E L
Sbjct: 352 AIINEDPNARLIRELQEEVARLRELL 377


>gi|157502184 kinesin family member 6 [Homo sapiens]
          Length = 814

 Score =  232 bits (592), Expect = 2e-60
 Identities = 183/558 (32%), Positives = 278/558 (49%), Gaps = 76/558 (13%)

Query: 27  IKVFVRIRPPAERSG----SADGEQNLC--LSVLSSTSLR---LHSNPEPKTFTFDHVAD 77
           I++F R++PP  +      S D ++ L   L ++    L    +++  E   F F  + D
Sbjct: 6   IQIFARVKPPVRKHQQGIYSIDEDEKLIPSLEIILPRDLADGFVNNKRESYKFKFQRIFD 65

Query: 78  VDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIP 137
            D  QE+VF  +AK +  S ++GYNGTIFAYGQTGSGKTFT+ G +E     ++ RG+IP
Sbjct: 66  QDANQETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAE----RYSDRGIIP 121

Query: 138 RSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAGLYLREHIK----- 192
           R+  Y+F  + ++     + K +    S++EIYNE  YDLLD       L +  K     
Sbjct: 122 RTLSYIFEQLQKD-----SSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILE 176

Query: 193 ---KGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEK 249
              + + +        T+  EA  +L  G  NR +A T MN+ S+RSH +FTI + S E 
Sbjct: 177 DPDQNIHLKNLTLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEP 236

Query: 250 SNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGK 309
            +    +R + L+LVDLAGSER   T   G  L EA  IN SL  L QVI AL       
Sbjct: 237 GS--ATVRHAKLHLVDLAGSERVAKTGVGGHLLTEAKYINLSLHYLEQVIIAL---SEKH 291

Query: 310 QRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVV 369
           + H+ YR+S +T +LRDSLGGN  T +IA +    R   E++ST  FAQR  LIKN+AV+
Sbjct: 292 RSHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLEKRNLDESISTCRFAQRVALIKNEAVL 351

Query: 370 NEDTQGN--VSQLQAEVKRLKEQLAELASGQTPPES-----FLTRDKKKTNYMEYFQEAM 422
           NE+      + +LQ E++ LK++LA + +G+   E+      L  +K  T+++E      
Sbjct: 352 NEEINPRLVIKRLQKEIQELKDELA-MVTGEQRTEALTEAELLQLEKLITSFLE------ 404

Query: 423 LFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMI--VKFREDQIIRLEKLHKESRGG 480
                 +Q+  S +E      D+      F    K++   K  E+  +  E   ++ +  
Sbjct: 405 ------DQDSDSRLEVGA---DMRKVHHCFHHLKKLLNDKKILENNTVSSESKDQDCQEP 455

Query: 481 FLPEEQDRL---LSELRNEIQTLREQIEHHPRVAKYA-----MENHSLR----------- 521
              EE  +L   L +  NEI  L   ++   + A+ A     M+    R           
Sbjct: 456 LKEEEYRKLRDILKQRDNEINILVNMLKKEKKKAQEALHLAGMDRREFRQSQSPPFRLGN 515

Query: 522 -EENRRLRLLEPVKRAQE 538
            EE +R+RL     +AQ+
Sbjct: 516 PEEGQRMRLSSAPSQAQD 533



 Score = 34.7 bits (78), Expect = 0.65
 Identities = 103/566 (18%), Positives = 232/566 (40%), Gaps = 87/566 (15%)

Query: 866  SYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEK-----------ERNN 914
            S ++L ++   E    + +L+N      T + +  NL+ L +  +            R++
Sbjct: 165  SLEDLPKVTILEDPDQNIHLKNLTLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSH 224

Query: 915  KLSLQFEEDKENSSKEI----LKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVI 970
             +       KE  S  +    L +++    E+  +T      + + + +  SL   E+VI
Sbjct: 225  CIFTIHLSSKEPGSATVRHAKLHLVDLAGSERVAKTGVGGHLLTEAKYINLSLHYLEQVI 284

Query: 971  SSLEKSRDSDKKVVADLMNQIQELRTSVCEK--TETIDTLKQELKDIN-----CKY---- 1019
             +L +   S       +M  +  LR S+     T  I TL  E ++++     C++    
Sbjct: 285  IALSEKHRSHIPYRNSMMTSV--LRDSLGGNCMTTMIATLSLEKRNLDESISTCRFAQRV 342

Query: 1020 ----NSALVDRE-ESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNM 1074
                N A+++ E   R++IK+ + +I +LK+ L + +  E     +   +L    + +  
Sbjct: 343  ALIKNEAVLNEEINPRLVIKRLQKEIQELKDELAM-VTGEQRTEALTEAELLQLEKLITS 401

Query: 1075 LTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDS 1134
              E     S L   A          ++++ H  +  K+ +  KK   N  +       +S
Sbjct: 402  FLEDQDSDSRLEVGAD---------MRKVHHCFHHLKKLLNDKKILENNTVSS-----ES 447

Query: 1135 AAEDPQSPKTPPHFQTHLAKLLETQEQEIED-----GRASKTSLEHLVTKLNEDREVKNA 1189
              +D Q P     ++  L  +L+ ++ EI        +  K + E L     + RE + +
Sbjct: 448  KDQDCQEPLKEEEYRK-LRDILKQRDNEINILVNMLKKEKKKAQEALHLAGMDRREFRQS 506

Query: 1190 EILRMK-EQLREMENLRLESQQLIEKNWLLQGQLDDIKRQK---------------ENSD 1233
            +    +     E + +RL S     +++ + G+   +  +K               E   
Sbjct: 507  QSPPFRLGNPEEGQRMRLSSAPSQAQDFSILGKRSSLLHKKIGMREEMSLGCQEAFEIFK 566

Query: 1234 QNHPDNQQLKNEQEESIKERLAKSKIVEEML-KMKADLEEVQSALYNKEMECLRMTDEVE 1292
            ++H D+  + ++ ++ +K+R +++K + E + + ++ +  ++  +  + ++ + +   + 
Sbjct: 567  RDHADSVTI-DDNKQILKQRFSEAKALGESINEARSKIGHLKEEITQRHIQQVALG--IS 623

Query: 1293 RTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQK 1352
                +     Q++E+LRS+LEE     +     ++ L+ ++E L          Q L  K
Sbjct: 624  ENMAVPLMPDQQEEKLRSQLEEEKRRYKTMFTRLKALKVEIEHL----------QLLMDK 673

Query: 1353 IQYVVRLKKE-NVRLAEETEKLRAEN 1377
             +  V+L+KE  V  AEE   L+  +
Sbjct: 674  AK--VKLQKEFEVWWAEEATNLQVNS 697



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 62/348 (17%), Positives = 140/348 (40%), Gaps = 40/348 (11%)

Query: 493 LRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFS 552
           ++NE   L E+I     + +   E   L++E   L ++   +R + +    + +LEK  +
Sbjct: 345 IKNEA-VLNEEINPRLVIKRLQKEIQELKDE---LAMVTGEQRTEALTEAELLQLEKLIT 400

Query: 553 EISGMEKSDKNQQGFSPKAQKEPCLFANTEKL--KAQLLQIQTELNNSK----------Q 600
                + SD   +  +   +   C F + +KL    ++L+  T  + SK          +
Sbjct: 401 SFLEDQDSDSRLEVGADMRKVHHC-FHHLKKLLNDKKILENNTVSSESKDQDCQEPLKEE 459

Query: 601 EYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIIT 660
           EY + +++ ++R  E+   +  L+K     +  L      +R+      +  +   ++  
Sbjct: 460 EYRKLRDILKQRDNEINILVNMLKKEKKKAQEALHLAGMDRRE----FRQSQSPPFRL-G 514

Query: 661 TPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELR 720
            P +  ++     P  + +    G    + SS+L   I          ++AFE    +  
Sbjct: 515 NPEEGQRMRLSSAPSQAQDFSILG----KRSSLLHKKIGMREEMSLGCQEAFEIFKRDHA 570

Query: 721 ---TVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQE-------LFSSERIDWT- 769
              T+ +    L+ +  E +     + +   K+ H   ++ +       L  SE +    
Sbjct: 571 DSVTIDDNKQILKQRFSEAKALGESINEARSKIGHLKEEITQRHIQQVALGISENMAVPL 630

Query: 770 ---KQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKEL 814
              +Q+E+L SQL   +++ +   T+   LK E+  L++++  A  +L
Sbjct: 631 MPDQQEEKLRSQLEEEKRRYKTMFTRLKALKVEIEHLQLLMDKAKVKL 678


>gi|7661878 kinesin family member 14 [Homo sapiens]
          Length = 1648

 Score =  228 bits (580), Expect = 4e-59
 Identities = 206/679 (30%), Positives = 330/679 (48%), Gaps = 87/679 (12%)

Query: 23  EGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPEPKT----------FTF 72
           E   + V VR+RP  +R       Q + +S    T      +P+ K           ++F
Sbjct: 355 ENSQVTVAVRVRPFTKREKIEKASQVVFMSGKEITV----EHPDTKQVYNFIYDVSFWSF 410

Query: 73  DHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNL 132
           D       +Q +V+  +A  ++E    G+N  +FAYGQTGSGK++TMMG SE        
Sbjct: 411 DECHPHYASQTTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMGFSEEP------ 464

Query: 133 RGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLL------DSASAGLY 186
            G+IPR  E LFS + R++ +     S+  + SF E+YNE+I+DLL            L 
Sbjct: 465 -GIIPRFCEDLFSQVARKQTQE---VSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLR 520

Query: 187 LREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTIT--- 243
           +REH   G +V      +V+S A+    L  G + R  A+T MN +SSRSH+VFT+    
Sbjct: 521 VREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQ 580

Query: 244 -----IESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQV 298
                +E  E  + I    TS +NL+DLAGSER    H  G RLKE  +IN+SL  LG+V
Sbjct: 581 TKTEFVEGEEHDHRI----TSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKV 636

Query: 299 ITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQ 358
           I+AL +  N +   + YR+S LT+LL++SLGGN+KTA+IA + P +    ETLSTL +A 
Sbjct: 637 ISALSEQANQRSVFIPYRESVLTWLLKESLGGNSKTAMIATISPAASNIEETLSTLRYAN 696

Query: 359 RAKLIKNKAVVNEDTQGN-VSQLQAEVKRLKEQLAELASGQTPPESF-LTRDKKKTNYME 416
           +A+LI N A VNED     + +L+AE+ +LK   A+  S    PE + L R +  +  M+
Sbjct: 697 QARLIVNIAKVNEDMNAKLIRELKAEIAKLK--AAQRNSRNIDPERYRLCRQEITSLRMK 754

Query: 417 YFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKE 476
             Q+     +   + ++   EK  Q E   L++ K +Q   ++ +  ++ +  L  L+++
Sbjct: 755 LHQQE----RDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQM-DNHLPNLVNLNED 809

Query: 477 SRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAM-ENHSLREENRRLRLLEPVKR 535
            +   L E    ++ E    +   +    H  +++   + ++H   +       + PV  
Sbjct: 810 PQ---LSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLIADDHCTIKNFGGTVSIIPVG- 865

Query: 536 AQEMDAQTIAKLEKAFSEISGMEKSDK----------------NQQGFSPKAQKEPCL-- 577
               +A+T     K   EI+ +   D+                 Q+G  P  +  P    
Sbjct: 866 ----EAKTYVN-GKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEG 920

Query: 578 -----FANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLEN 632
                FA  E L AQ  Q++ E+  ++ + +E  E+ +  Q+  E   Q L       E+
Sbjct: 921 PKDFEFAKNELLMAQRSQLEAEIKEAQLKAKE--EMMQGIQIAKEMAQQELSSQKAAYES 978

Query: 633 LLEATKACKRQEVSQLNKI 651
            ++A +A  R+E SQ  K+
Sbjct: 979 KIKALEAELREE-SQRKKM 996



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 87/435 (20%), Positives = 177/435 (40%), Gaps = 46/435 (10%)

Query: 519  SLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLF 578
            +LR  N+   ++   K  ++M+A+ I +L+   +EI+ ++ + +N +   P+  +     
Sbjct: 691  TLRYANQARLIVNIAKVNEDMNAKLIRELK---AEIAKLKAAQRNSRNIDPERYR--LCR 745

Query: 579  ANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATK 638
                 L+ +L Q + ++   ++ ++E  E   KR+L+   E + LQKA +  +       
Sbjct: 746  QEITSLRMKLHQQERDMAEMQRVWKEKFEQAEKRKLQ---ETKELQKAGIMFQMDNHLPN 802

Query: 639  ACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDI 698
                 E  QL+++    +K  TT    Y+      P  S ++   G L   +   + N  
Sbjct: 803  LVNLNEDPQLSEMLLYMIKEGTTTVGKYK------PNSSHDIQLSGVLIADDHCTIKNFG 856

Query: 699  LNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQ 758
                + P + E       + +  +       +  L  + +        V K +  S +  
Sbjct: 857  GTVSIIP-VGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDT 915

Query: 759  ELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVK 818
             +    +     + E L++Q + LE +++E Q K    +  +  +++    A +ELSS K
Sbjct: 916  PISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAK--EEMMQGIQIAKEMAQQELSSQK 973

Query: 819  LEYSS------------------FKTNQEKEFNKLSE-----RHMHVQLQLDNLRLENEK 855
              Y S                   + N +K  +K+ E     +H+  ++ ++  RLE E 
Sbjct: 974  AAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKRLEME- 1032

Query: 856  LLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNN- 914
             L +K  L+D       I    ++ L    Q   KE + L+ + NN  +    +   ++ 
Sbjct: 1033 TLATKQALEDHSIRHARI----LEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSM 1088

Query: 915  KLSLQFEEDKENSSK 929
            KLS+  +E    SSK
Sbjct: 1089 KLSMMIQEANAISSK 1103



 Score = 34.7 bits (78), Expect = 0.65
 Identities = 37/143 (25%), Positives = 71/143 (49%), Gaps = 20/143 (13%)

Query: 1243 KNEQEESIKERLAKSKIVEEMLKMKADLEEV-------QSALYNKEMECLRMTDEVERTQ 1295
            +++ E  IKE   K+K  EEM++     +E+       Q A Y  +++ L    E E  +
Sbjct: 936  RSQLEAEIKEAQLKAK--EEMMQGIQIAKEMAQQELSSQKAAYESKIKAL----EAELRE 989

Query: 1296 TLESKAFQE--KEQLRSKLEEMYEERERTSQEMEMLRK--QVECLAEENGKLVGHQNLHQ 1351
              + K  QE   ++   K+EE+ + ++   QE+ + +K  ++E LA +   L  H   H 
Sbjct: 990  ESQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQA-LEDHSIRHA 1048

Query: 1352 KIQYVVRLKKENVRLAEETEKLR 1374
            +I  +  L+ E  ++A+E + L+
Sbjct: 1049 RI--LEALETEKQKIAKEVQILQ 1069



 Score = 32.7 bits (73), Expect = 2.5
 Identities = 31/129 (24%), Positives = 60/129 (46%), Gaps = 10/129 (7%)

Query: 419  QEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMI-VKFREDQIIRLEKLHKES 477
            +EA L  K+   +   + +++ Q ++L+ +K  +    K +  + RE+   +  +     
Sbjct: 944  KEAQLKAKEEMMQGIQIAKEMAQ-QELSSQKAAYESKIKALEAELREESQRKKMQEINNQ 1002

Query: 478  RGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQ 537
            +     EE ++    L  EI   ++++E      K A+E+HS+    R  R+LE    A 
Sbjct: 1003 KANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALEDHSI----RHARILE----AL 1054

Query: 538  EMDAQTIAK 546
            E + Q IAK
Sbjct: 1055 ETEKQKIAK 1063


>gi|199560800 kinesin family member 9 isoform 2 [Homo sapiens]
          Length = 790

 Score =  224 bits (571), Expect = 4e-58
 Identities = 152/453 (33%), Positives = 252/453 (55%), Gaps = 38/453 (8%)

Query: 27  IKVFVRIRPPAERSGS----ADGEQNLCLSVLSSTSLRLHSNPEPK-TFTFDHVADVDTT 81
           +  FVR++P  + +       D ++++ + +       + +N +   +F  D V   D +
Sbjct: 7   VHAFVRVKPTDDFAHEMIRYGDDKRSIDIHLKKDIRRGVVNNQQTDWSFKLDGVLH-DAS 65

Query: 82  QESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFE 141
           Q+ V+ TVAK +V   + GYNGTI  YGQTG+GKT+TMMG +E  N+ H  RG++PR+ +
Sbjct: 66  QDLVYETVAKDVVSQALDGYNGTIMCYGQTGAGKTYTMMGATE--NYKH--RGILPRALQ 121

Query: 142 YLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDS------ASAGLYLREHIKKGV 195
            +F +I+     A        + S++EIYNE ++DLL +      +   + + E+  +GV
Sbjct: 122 QVFRMIEERPTHA-----ITVRVSYLEIYNESLFDLLSTLPYVGPSVTPMTIVEN-PQGV 175

Query: 196 FVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNEIVN 255
           F+ G    + +   +A+ +L  G  NR +AS +MN+ SSRSH +FTI +E+  ++     
Sbjct: 176 FIKGLSVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIYLEAHSRTLSEEK 235

Query: 256 IRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCY 315
             TS +NLVDLAGSER   + +EG  LKEA  IN+SLS L Q I AL   G+ K+ H+ +
Sbjct: 236 YITSKINLVDLAGSERLGKSGSEGQVLKEATYINKSLSFLEQAIIAL---GDQKRDHIPF 292

Query: 316 RDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNE--DT 373
           R  KLT  L+DSLGGN    ++ N++  +    ETLS+L FA R KL+  +  +NE  D 
Sbjct: 293 RQCKLTHALKDSLGGNCNMVLVTNIYGEAAQLEETLSSLRFASRMKLVTTEPAINEKYDA 352

Query: 374 QGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKK 433
           +  V  L+ E+  LK++LA          +F+T D      M+  Q A +    + Q ++
Sbjct: 353 ERMVKNLEKELALLKQELA--IHDSLTNRTFVTYDP-----MDEIQIAEI----NSQVRR 401

Query: 434 SLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQ 466
            L   + +++ ++L++ K + +   +V  +++Q
Sbjct: 402 YLEGTLDEIDIISLRQIKEVFNQFRVVLSQQEQ 434


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.333 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,078,354
Number of Sequences: 37866
Number of extensions: 2140317
Number of successful extensions: 30408
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 464
Number of HSP's successfully gapped in prelim test: 1338
Number of HSP's that attempted gapping in prelim test: 10810
Number of HSP's gapped (non-prelim): 8980
length of query: 1388
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1273
effective length of database: 13,892,928
effective search space: 17685697344
effective search space used: 17685697344
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.