Search of human proteins with 96975023

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
         (522 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...  1050   0.0  
gi|239742602 PREDICTED: ankyrin repeat and death domain containi...   324   1e-88
gi|239754056 PREDICTED: ankyrin repeat and death domain containi...   302   6e-82
gi|239748583 PREDICTED: ankyrin repeat and death domain containi...   302   6e-82
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   173   3e-43
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        165   1e-40
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   164   1e-40
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       157   3e-38
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        157   3e-38
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        157   3e-38
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        157   3e-38
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        157   3e-38
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       156   4e-38
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        156   4e-38
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        156   4e-38
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   156   5e-38
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  154   2e-37
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   150   4e-36
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          147   3e-35
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    143   4e-34
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   140   2e-33
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   140   2e-33
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   139   8e-33
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            137   2e-32
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   136   5e-32
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    136   5e-32
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                    134   2e-31
gi|30348954 mindbomb homolog 1 [Homo sapiens]                         132   6e-31
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is...   127   3e-29
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   123   5e-28

>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score = 1050 bits (2714), Expect = 0.0
 Identities = 522/522 (100%), Positives = 522/522 (100%)

Query: 1   MQEELAWETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGH 60
           MQEELAWETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGH
Sbjct: 1   MQEELAWETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGH 60

Query: 61  EQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCE 120
           EQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCE
Sbjct: 61  EQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCE 120

Query: 121 SKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVG 180
           SKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVG
Sbjct: 121 SKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVG 180

Query: 181 SGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDC 240
           SGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDC
Sbjct: 181 SGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDC 240

Query: 241 VQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVR 300
           VQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVR
Sbjct: 241 VQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVR 300

Query: 301 HNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTA 360
           HNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTA
Sbjct: 301 HNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTA 360

Query: 361 LAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSVLWRLAS 420
           LAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSVLWRLAS
Sbjct: 361 LAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSVLWRLAS 420

Query: 421 RYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLIWLHGVATAGENPSKA 480
           RYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLIWLHGVATAGENPSKA
Sbjct: 421 RYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLIWLHGVATAGENPSKA 480

Query: 481 LFEGLVAIGRRDLAGWSTMARSQLTATSASRVQMILVPQPPE 522
           LFEGLVAIGRRDLAGWSTMARSQLTATSASRVQMILVPQPPE
Sbjct: 481 LFEGLVAIGRRDLAGWSTMARSQLTATSASRVQMILVPQPPE 522


>gi|239742602 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 607

 Score =  324 bits (830), Expect = 1e-88
 Identities = 193/499 (38%), Positives = 282/499 (56%), Gaps = 34/499 (6%)

Query: 12  LLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHE 71
           LLP ER    AA+ NN+  M++L  ++VN    N++ R ALH+A G  H  AV  LL+H+
Sbjct: 65  LLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHK 124

Query: 72  AAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCA 131
           A VD  D            G+  + L+AW G L ++ +LV +GA    +++DG++ LH A
Sbjct: 125 ARVDVADK----------HGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFA 174

Query: 132 AQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE 191
            Q  HV ++ ++++DL    L+  D+ GR  F  AAE G ++ ++ L       + KDK 
Sbjct: 175 TQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKI 234

Query: 192 GNTALHLAA------GRGHMAVL--QRLVDIGLDLEEQNAE----GLTALHSAAGGSHPD 239
             + L  AA       R  +A L  +     G  +   +      G TALH AA   H  
Sbjct: 235 QWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSP 294

Query: 240 CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGA----SPL 295
            VQ+LL     +N + + N+S L  A  +G   +   L+      NV  HQ      SPL
Sbjct: 295 AVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE----NVDLHQKVEPKESPL 350

Query: 296 HLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDK 355
           HL V +N   +V  L+++  D++ ++ +QQTPLH+AA+    ++ + LL AG DL   DK
Sbjct: 351 HLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDK 410

Query: 356 QGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPS---DPS-GKSLSFKQDHRQETQQL 411
           QGKTALAVA RSNH  +V M+IKA+R+Y W ++H     DPS G +L+FKQDH  ET+ +
Sbjct: 411 QGKTALAVASRSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHI 470

Query: 412 RSVLWRLASRYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLIWLHGVA 471
           R++LW LA   L+  EW++LA SW FT+  + AIE+QW+G  S++EHGHR LLIWLHG  
Sbjct: 471 RTLLWDLAYHQLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLIWLHGTL 530

Query: 472 TAGENPSKALFEGLVAIGR 490
               +P+K L+E L A+ R
Sbjct: 531 MTQGDPAKQLYEELEAVYR 549


>gi|239754056 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 524

 Score =  302 bits (773), Expect = 6e-82
 Identities = 182/474 (38%), Positives = 267/474 (56%), Gaps = 34/474 (7%)

Query: 12  LLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHE 71
           LLP ER    AA+ NN+  M++L  ++VN    N++ R ALH+A G  H  AV  LL+H+
Sbjct: 65  LLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHK 124

Query: 72  AAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCA 131
           A VD  D            G+  + L+AW G L ++ +LV +GA    +++DG++ LH A
Sbjct: 125 ARVDVADK----------HGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFA 174

Query: 132 AQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE 191
            Q  HV ++ ++++DL    L+  D+ GR  F  AAE G ++ ++ L       + KDK 
Sbjct: 175 TQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKI 234

Query: 192 GNTALHLAA------GRGHMAVL--QRLVDIGLDLEEQNAE----GLTALHSAAGGSHPD 239
             + L  AA       R  +A L  +     G  +   +      G TALH AA   H  
Sbjct: 235 QWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSP 294

Query: 240 CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGA----SPL 295
            VQ+LL     +N + + N+S L  A  +G   +   L+      NV  HQ      SPL
Sbjct: 295 AVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE----NVDLHQKVEPKESPL 350

Query: 296 HLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDK 355
           HL V +N   +V  L+++  D++ ++ +QQTPLH+AA+    ++ + LL AG DL   DK
Sbjct: 351 HLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDK 410

Query: 356 QGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPS---DPS-GKSLSFKQDHRQETQQL 411
           QGKTALAVA RSNH  +V M+IKA+R+Y W ++H     DPS G +L+FKQDH  ET+ +
Sbjct: 411 QGKTALAVASRSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHI 470

Query: 412 RSVLWRLASRYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLI 465
           R++LW LA   L+  EW++LA SW FT+  + AIE+QW+G  S++EHGHR LLI
Sbjct: 471 RTLLWDLAYHQLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524


>gi|239748583 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 524

 Score =  302 bits (773), Expect = 6e-82
 Identities = 182/474 (38%), Positives = 267/474 (56%), Gaps = 34/474 (7%)

Query: 12  LLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHE 71
           LLP ER    AA+ NN+  M++L  ++VN    N++ R ALH+A G  H  AV  LL+H+
Sbjct: 65  LLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHK 124

Query: 72  AAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCA 131
           A VD  D            G+  + L+AW G L ++ +LV +GA    +++DG++ LH A
Sbjct: 125 ARVDVADK----------HGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFA 174

Query: 132 AQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE 191
            Q  HV ++ ++++DL    L+  D+ GR  F  AAE G ++ ++ L       + KDK 
Sbjct: 175 TQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKI 234

Query: 192 GNTALHLAA------GRGHMAVL--QRLVDIGLDLEEQNAE----GLTALHSAAGGSHPD 239
             + L  AA       R  +A L  +     G  +   +      G TALH AA   H  
Sbjct: 235 QWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSP 294

Query: 240 CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGA----SPL 295
            VQ+LL     +N + + N+S L  A  +G   +   L+      NV  HQ      SPL
Sbjct: 295 AVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE----NVDLHQKVEPKESPL 350

Query: 296 HLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDK 355
           HL V +N   +V  L+++  D++ ++ +QQTPLH+AA+    ++ + LL AG DL   DK
Sbjct: 351 HLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDK 410

Query: 356 QGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPS---DPS-GKSLSFKQDHRQETQQL 411
           QGKTALAVA RSNH  +V M+IKA+R+Y W ++H     DPS G +L+FKQDH  ET+ +
Sbjct: 411 QGKTALAVASRSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHI 470

Query: 412 RSVLWRLASRYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLI 465
           R++LW LA   L+  EW++LA SW FT+  + AIE+QW+G  S++EHGHR LLI
Sbjct: 471 RTLLWDLAYHQLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  173 bits (439), Expect = 3e-43
 Identities = 124/384 (32%), Positives = 190/384 (49%), Gaps = 30/384 (7%)

Query: 19  LHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDE 76
           LH AA   +   ++ LI  G RVN  A++++    LH A  +  E+AV++L++H A V+ 
Sbjct: 20  LHVAAFLGDAEIIELLILSGARVN--AKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77

Query: 77  EDA-------VGALTEARLCF----------------GMNALLLSAWFGHLRILQILVNS 113
            D        V A  +A  C                 G  AL  +A  GH+ ++ +L+  
Sbjct: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137

Query: 114 GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLD 173
           GA I+   K     LH AA  GH+ V+A ++    +V     DK G T  H AA +GQ++
Sbjct: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK--DKKGYTPLHAAASNGQIN 195

Query: 174 ALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAA 233
            +  L+  G + +  +  GNTALH+A   G  AV+  L+D G ++ + N  G T LH AA
Sbjct: 196 VVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAA 255

Query: 234 GGSHPD-CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGA 292
             +H   C++LL+  G+ VN  ++   S LH  A+ G    S+ LI  GG  + VD  G 
Sbjct: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315

Query: 293 SPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNL 352
           +PLH+A R+    L+  L  S +D          PLHLAA +A  D    LL +G +++ 
Sbjct: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDT 375

Query: 353 RDKQGKTALAVAVRSNHVSLVDMI 376
            DK G+T L  A    +V  + ++
Sbjct: 376 PDKFGRTCLHAAAAGGNVECIKLL 399



 Score =  140 bits (353), Expect = 3e-33
 Identities = 114/445 (25%), Positives = 192/445 (43%), Gaps = 54/445 (12%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA   +V  +  L+ +  N  A +   R ALHWAA  GH   V LL+ H A V  +D
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178

Query: 79  AVG------ALTEARL-----------------CFGMNALLLSAWFGHLRILQILVNSGA 115
             G      A +  ++                  +G  AL ++ + G   ++  L++ GA
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238

Query: 116 KIHCESKDGLTLLHCAAQKGHVPV-LAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA 174
            ++  + +G T LH AA   H  + L  ++ +  DV +   D  G++  H  A HG+   
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD--GKSPLHMTAVHGRFTR 296

Query: 175 LDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAG 234
              L+ +G + +  DK+GNT LH+AA  GH  ++  L   G D  +     +  LH AA 
Sbjct: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356

Query: 235 GSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASP 294
            +H DC + LL +G  ++   +   +CLH AA  G+ +  ++L  +G   +  D  G +P
Sbjct: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416

Query: 295 LHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAA---------------------- 332
           LH A  +     +  L+ + ++VN  D+  +T LH AA                      
Sbjct: 417 LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELE 476

Query: 333 ------EHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWE 386
                 E       + LL    + ++RDK+G  ++  A    H   ++++++       E
Sbjct: 477 RARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEE 536

Query: 387 KDHPSDPSGKSLSFKQDHRQETQQL 411
            D  +  S   L+    H Q  + L
Sbjct: 537 SDSGATKSPLHLAAYNGHHQALEVL 561



 Score =  137 bits (345), Expect = 2e-32
 Identities = 113/413 (27%), Positives = 180/413 (43%), Gaps = 56/413 (13%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA    +  ++ L+   V     N  G  ALH A   G +  V  L+++ A V++ +
Sbjct: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244

Query: 79  AVG--------ALTEARLCF----------------GMNALLLSAWFGHLRILQILVNSG 114
             G        A T   LC                 G + L ++A  G     Q L+ +G
Sbjct: 245 NNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNG 304

Query: 115 AKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA 174
            +I C  KDG T LH AA+ GH  ++  +     D A   +  +     H AA +   D 
Sbjct: 305 GEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM--FPLHLAALNAHSDC 362

Query: 175 LDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAG 234
              L+ SG + +  DK G T LH AA  G++  ++ L   G D  +++  G T LH AA 
Sbjct: 363 CRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAA 422

Query: 235 GSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALS--------------GSEDVSRV---- 276
             H  C++ L+  G+ VN       + LHYAA S               SE++ R     
Sbjct: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482

Query: 277 ----------LIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLI-NSDSDVNAVDN-RQ 324
                     L+      ++ D +G + +H A  +     + LL+  ++S     D+   
Sbjct: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 542

Query: 325 QTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
           ++PLHLAA +      ++LL + VDL++RD++G+TAL +A    H   V+ +I
Sbjct: 543 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALI 595



 Score =  125 bits (314), Expect = 9e-29
 Identities = 101/365 (27%), Positives = 170/365 (46%), Gaps = 15/365 (4%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA   +   ++ L+   V+   R+  GR AL  AA  GH + V  L+   A++  +D
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
            V   T       ++A +++     LR+L  + ++   +  +   G T L  A   GH+ 
Sbjct: 606 NVTKRTP------LHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
            ++ ++E  ++  +D VD LG TA HR    G  + +  L+        KD  G T LH 
Sbjct: 660 AVSLLLE--KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHY 717

Query: 199 AAGRGHMAVLQRLVDIGLDLEE---QNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALT 255
           AA RGH   L  L+ + L  E+   ++ +G T LH A    + +C+++LL          
Sbjct: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ-KCFRKFI 776

Query: 256 QKNLSCLHYAALSGSEDVSRVLIHA--GGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
               + LH A ++   + + +L+ A      +  D +G +PL  A   +    ++LL+  
Sbjct: 777 GNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836

Query: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLL-IAGVDLNLRDKQGKTALAVAVRSNHVSL 372
            + VNAVDN  +T L +AAE+      D+L+  A  DL ++DK   T L +A    H   
Sbjct: 837 SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896

Query: 373 VDMII 377
             +I+
Sbjct: 897 ALLIL 901



 Score =  119 bits (298), Expect = 7e-27
 Identities = 104/359 (28%), Positives = 165/359 (45%), Gaps = 24/359 (6%)

Query: 31  MQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCF 90
           ++ L+    N   R+  G  ++H+AA  GH Q + LLLE   +  EE   GA        
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK------ 543

Query: 91  GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP-VLAFIMEDLED 149
             + L L+A+ GH + L++L+ S   +    + G T L  AA KGH   V A I      
Sbjct: 544 --SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601

Query: 150 VALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDH---NVKDKEGNTALHLAAGRGHMA 206
              D+V K  RT  H +  +G    L  L+    +    +VKD +G T L LA   GH+ 
Sbjct: 602 FVKDNVTK--RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659

Query: 207 VLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAA 266
            +  L++   +++  +  G TALH      H +CVQ+LL    ++     +  + LHYAA
Sbjct: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719

Query: 267 LSG-----SEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVD 321
             G     SE +   L     C    D+QG +PLH A  +     + +L+        + 
Sbjct: 720 ARGHATWLSELLQMALSEEDCCFK--DNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG 777

Query: 322 NRQQTPLHLAAEHAWQDIADMLL--IAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
           N   TPLH A  +   + A +LL  I    ++ RD +G+T L  A  ++HV  + ++++
Sbjct: 778 N-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR 835



 Score =  113 bits (282), Expect = 5e-25
 Identities = 73/264 (27%), Positives = 126/264 (47%), Gaps = 2/264 (0%)

Query: 109 ILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAE 168
           +L++    ++    +  T LH AA  G   ++  ++  L    ++  D +  T  HRA  
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLI--LSGARVNAKDNMWLTPLHRAVA 58

Query: 169 HGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTA 228
               +A+  L+    D N +DK   T LH+AA    +   + ++ +   +   +  G TA
Sbjct: 59  SRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118

Query: 229 LHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVD 288
           LH AA   H + V LLL  G+ +NA  +K+   LH+AA  G  DV  +LI+ G      D
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178

Query: 289 HQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGV 348
            +G +PLH A  +    +V+ L+N   +++ ++    T LH+A  +    + + L+  G 
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238

Query: 349 DLNLRDKQGKTALAVAVRSNHVSL 372
           ++N  +  G T L  A  S H +L
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGAL 262



 Score =  111 bits (278), Expect = 1e-24
 Identities = 110/407 (27%), Positives = 174/407 (42%), Gaps = 50/407 (12%)

Query: 8   ETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLL 67
           + DG  PL    H AAR  +   +  L     +T          LH AA   H    R L
Sbjct: 311 DKDGNTPL----HVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366

Query: 68  LEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTL 127
           L     +D  D           FG   L  +A  G++  +++L +SGA  H + K G T 
Sbjct: 367 LSSGFEIDTPDK----------FGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416

Query: 128 LHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH----------------------- 164
           LH AA   H   +  ++    +V  +  D  GRTA H                       
Sbjct: 417 LHYAAANCHFHCIETLVTTGANV--NETDDWGRTALHYAAASDMDRNKTILGNAHDNSEE 474

Query: 165 --RAAEHGQLDA---LDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 219
             RA E  + +A   L+FL+ +  + +++DKEG  ++H AA  GH   L+ L++      
Sbjct: 475 LERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534

Query: 220 EQNAEGLTA--LHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVL 277
           E++  G T   LH AA   H   +++LL++   ++   +K  + L  AA  G  +    L
Sbjct: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594

Query: 278 IHAGGCANVVDH-QGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQ---QTPLHLAAE 333
           I+ G    V D+    +PLH +V +     +RLL+    +  AVD +    QTPL LA  
Sbjct: 595 INPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654

Query: 334 HAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKAD 380
           +   D   +LL    +++  D  G TAL   + + H   V M+++ +
Sbjct: 655 YGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701



 Score =  100 bits (250), Expect = 2e-21
 Identities = 69/235 (29%), Positives = 113/235 (48%), Gaps = 2/235 (0%)

Query: 143 IMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGR 202
           ++   EDV  + +D   RT  H AA  G  + ++ L+ SG   N KD    T LH A   
Sbjct: 2   LIHKTEDV--NTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVAS 59

Query: 203 GHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCL 262
                +Q L+    D+  ++    T LH AA      C ++++   S+VN   +   + L
Sbjct: 60  RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119

Query: 263 HYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDN 322
           H+AAL+G  ++  +L+  G   N  D +    LH A       +V LLIN  ++V   D 
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179

Query: 323 RQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
           +  TPLH AA +   ++   LL  GV+++  +  G TAL +A  +   ++V+ +I
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI 234



 Score = 92.4 bits (228), Expect = 9e-19
 Identities = 90/289 (31%), Positives = 131/289 (45%), Gaps = 24/289 (8%)

Query: 48  GRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRIL 107
           G+  L  A   GH  AV LLLE EA VD  D +G            AL      GH   +
Sbjct: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGC----------TALHRGIMTGHEECV 694

Query: 108 QILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIME-DLEDVALDHVDKLGRTAFHRA 166
           Q+L+     I C+   G T LH AA +GH   L+ +++  L +      D  G T  H A
Sbjct: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754

Query: 167 AEHGQLDALDFLVGSGCDHNVKDKEGN--TALHLAAGRGH---MAVLQRLVDIGLDLEEQ 221
             +G  + ++ L+   C    +   GN  T LH A    H    ++L   +D  + +  +
Sbjct: 755 CYNGNENCIEVLLEQKC---FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSI-VSCR 810

Query: 222 NAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH-A 280
           + +G T L +AA   H +C+QLLLR  + VNA+     + L  AA +G      +L++ A
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870

Query: 281 GGCANVVDHQGASPLHLAVR--HNFPALVRL-LINSDSDVNAVDNRQQT 326
                V D    +PLHLA    H   AL+ L  I  +S +N  +N  QT
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNALQT 919



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 45/135 (33%), Positives = 74/135 (54%)

Query: 243 LLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHN 302
           +L+     VN L  +  + LH AA  G  ++  +LI +G   N  D+   +PLH AV   
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 303 FPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALA 362
               V++LI   +DVNA D   QTPLH+AA +     A++++     +N+ D+ G+TAL 
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 363 VAVRSNHVSLVDMII 377
            A  + HV +V++++
Sbjct: 121 HAALNGHVEMVNLLL 135



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 72/269 (26%), Positives = 108/269 (40%), Gaps = 71/269 (26%)

Query: 22  AARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVG 81
           A    ++  +  L+ +  N    + +G  ALH     GHE+ V++LLE E ++  +D+ G
Sbjct: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711

Query: 82  ----------------------ALTEARLCF----GMNALLLSAWFGHLRILQILVNSGA 115
                                 AL+E   CF    G   L  + + G+   +++L+    
Sbjct: 712 RTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ-- 769

Query: 116 KIHCESK---DGLTLLHCAA------------------------QKGHVPVLAFIMED-- 146
              C  K   +  T LHCA                          KG  P+ A    D  
Sbjct: 770 --KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827

Query: 147 -------LEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG-CDHNVKDKEGNTALHL 198
                       ++ VD  G+TA   AAE+GQ  A+D LV S   D  VKDK+ NT LHL
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHL 887

Query: 199 AAGRGH----MAVLQRLVDIGLDLEEQNA 223
           A  +GH    + +L ++ D  L  E+ NA
Sbjct: 888 ACSKGHEKCALLILDKIQDESLINEKNNA 916



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 25/70 (35%), Positives = 42/70 (60%)

Query: 309 LLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSN 368
           +LI+   DVN +D+ ++TPLH+AA     +I ++L+++G  +N +D    T L  AV S 
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 369 HVSLVDMIIK 378
               V ++IK
Sbjct: 61  SEEAVQVLIK 70


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  165 bits (417), Expect = 1e-40
 Identities = 111/391 (28%), Positives = 182/391 (46%), Gaps = 29/391 (7%)

Query: 10  DGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLE 69
           DGL PL    H  AR  +   ++ L+ R     ++   G   LH A    H   V+LLL+
Sbjct: 300 DGLTPL----HCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ 355

Query: 70  HEAAVDE--EDAVGALTEARLCF---------------------GMNALLLSAWFGHLRI 106
           H   VD+   D + AL  A  C                      G   L ++     +++
Sbjct: 356 HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKV 415

Query: 107 LQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRA 166
           +++L+  GA I   ++ GLT +H AA  GHV +++ +M      + +  +  G TA H A
Sbjct: 416 MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH--HGASPNTTNVRGETALHMA 473

Query: 167 AEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGL 226
           A  GQ + + +LV  G     K K+  T LH++A  G   ++Q+L+  G         G 
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533

Query: 227 TALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANV 286
           T LH +A   H D    LL  G++++  T+K  + LH AA  G  +V+ +L+      + 
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593

Query: 287 VDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIA 346
               G +PLH+A  ++   +  LL++  +  +A      TPLH+AA+    DIA  LL  
Sbjct: 594 AGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEY 653

Query: 347 GVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
           G D N   +QG  ++ +A +  HV +V +++
Sbjct: 654 GADANAVTRQGIASVHLAAQEGHVDMVSLLL 684



 Score =  157 bits (397), Expect = 2e-38
 Identities = 107/368 (29%), Positives = 174/368 (47%), Gaps = 16/368 (4%)

Query: 11  GLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEH 70
           GL P+    H AA   +V  + +L+    +    N  G  ALH AA +G  + VR L++ 
Sbjct: 433 GLTPI----HVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488

Query: 71  EAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHC 130
                     GA  EA+       L +SA  G   I+Q L+  GA  +  +  G T LH 
Sbjct: 489 ----------GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHL 538

Query: 131 AAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDK 190
           +A++GH  V AF+++     +L    K G T  H AA++G+L+  + L+      +   K
Sbjct: 539 SAREGHEDVAAFLLD--HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGK 596

Query: 191 EGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGST 250
            G T LH+AA   +  V   L+D G         G T LH AA  +  D    LL  G+ 
Sbjct: 597 SGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656

Query: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
            NA+T++ ++ +H AA  G  D+  +L+      N+ +  G +PLHLA + +   +  +L
Sbjct: 657 ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           +N  + V+A      TPLH+   +    I + LL     +N + K G T L  A +  H 
Sbjct: 717 VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHT 776

Query: 371 SLVDMIIK 378
            +++++++
Sbjct: 777 HIINVLLQ 784



 Score =  153 bits (386), Expect = 4e-37
 Identities = 102/360 (28%), Positives = 175/360 (48%), Gaps = 12/360 (3%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A ++N +  M+ L+    + +A    G   +H AA  GH   V  L+ H A+ +   
Sbjct: 404 LHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT-- 461

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                T  R   G  AL ++A  G   +++ LV  GA++  ++KD  T LH +A+ G   
Sbjct: 462 -----TNVR---GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 513

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           ++  +++  +  + +     G T  H +A  G  D   FL+  G   ++  K+G T LH+
Sbjct: 514 IVQQLLQ--QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHV 571

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  G + V   L+      +     GLT LH AA   +     LLL  G++ +A  +  
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
            + LH AA     D++  L+  G  AN V  QG + +HLA +     +V LL+  +++VN
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
             +    TPLHLAA+    ++A++L+  G  ++ + K G T L V     ++ +V+ +++
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 751



 Score =  152 bits (384), Expect = 7e-37
 Identities = 118/420 (28%), Positives = 189/420 (45%), Gaps = 70/420 (16%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A+++ +V  + EL+ R  N  A    G  ALH A+ AG  + V++L+ +        
Sbjct: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTN-------- 129

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L ++A   HL +++ L+++GA     ++DG T L  A Q+GH  
Sbjct: 130 --GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQ 187

Query: 139 VLAFIME-------------------DLEDVAL--------DHVDKLGRTAFHRAAEHGQ 171
           V++ ++E                   D +  AL        D   K G T  H AA +G 
Sbjct: 188 VVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGN 247

Query: 172 LD----------ALDF-----------------------LVGSGCDHNVKDKEGNTALHL 198
           ++          A+DF                       L+  G   + K ++G T LH 
Sbjct: 248 INVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHC 307

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
            A  GH  V++ L+D    +  +   GL+ LH A  G H +CVQLLL+    V+ +T   
Sbjct: 308 GARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDY 367

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           L+ LH AA  G   V++VL+      N     G +PLH+A + N   ++ LL+   + + 
Sbjct: 368 LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQ 427

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
           AV     TP+H+AA     +I   L+  G   N  + +G+TAL +A RS    +V  +++
Sbjct: 428 AVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQ 487



 Score =  125 bits (315), Expect = 7e-29
 Identities = 96/358 (26%), Positives = 155/358 (43%), Gaps = 45/358 (12%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH +AR      +Q+L+ +  +  A    G   LH +A  GHE     LL+H A++    
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL---- 558

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
              ++T  +   G   L ++A +G L +  +L+   A      K GLT LH AA   +  
Sbjct: 559 ---SITTKK---GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQK 612

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           V   +++  +  +     K G T  H AA+  Q+D    L+  G D N   ++G  ++HL
Sbjct: 613 VALLLLD--QGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  GH+ ++  L+    ++   N  GLT LH AA     +  ++L+  G+ V+A T+  
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK-- 728

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
                                           G +PLH+   +    +V  L+   + VN
Sbjct: 729 -------------------------------MGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMI 376
           A      TPLH AA+     I ++LL      N     G TAL +A R  ++S+VD +
Sbjct: 758 AKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  124 bits (311), Expect = 2e-28
 Identities = 81/282 (28%), Positives = 139/282 (49%), Gaps = 6/282 (2%)

Query: 96  LLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHV 155
           L +A  GHL      + +G  I+  +++GL  LH A+++GHV V++ +++   +  +D  
Sbjct: 46  LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQ--REANVDAA 103

Query: 156 DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 215
            K G TA H A+  GQ + +  LV +G + N + + G T L++AA   H+ V++ L+D G
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163

Query: 216 LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSR 275
                   +G T L  A    H   V LLL      +   +  L  LH AA       + 
Sbjct: 164 ASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAA 219

Query: 276 VLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHA 335
           +L+     A+V    G +PLH+A  +    +  LL+N  + V+       TPLH+A++  
Sbjct: 220 LLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRG 279

Query: 336 WQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
             ++  +LL  G  ++ + + G T L    RS H  +V+M++
Sbjct: 280 NANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLL 321



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 60/217 (27%), Positives = 113/217 (52%), Gaps = 6/217 (2%)

Query: 162 AFHRAAEHGQLD-ALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEE 220
           ++ RAA  G L+ ALD+ + +G D N+ ++ G  ALHLA+  GH+ V+  L+    +++ 
Sbjct: 44  SYLRAARAGHLEKALDY-IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDA 102

Query: 221 QNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHA 280
              +G TALH A+     + V++L+  G+ VNA +Q   + L+ AA     +V + L+  
Sbjct: 103 ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDN 162

Query: 281 GGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIA 340
           G   ++    G +PL +A++     +V LL+ +D+        +   LH+AA       A
Sbjct: 163 GASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV----RLPALHIAARKDDTKAA 218

Query: 341 DMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
            +LL    + ++  K G T L +A    ++++  +++
Sbjct: 219 ALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 52/193 (26%), Positives = 94/193 (48%), Gaps = 4/193 (2%)

Query: 188 KDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 247
           K  + N +   AA  GH+      +  G+D+   N  GL ALH A+   H + V  LL+ 
Sbjct: 37  KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96

Query: 248 GSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALV 307
            + V+A T+K  + LH A+L+G  +V +VL+  G   N     G +PL++A + N   +V
Sbjct: 97  EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156

Query: 308 RLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRS 367
           + L+++ +  +       TPL +A +     +  +LL    + + + K    AL +A R 
Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL----ENDTKGKVRLPALHIAARK 212

Query: 368 NHVSLVDMIIKAD 380
           +      ++++ D
Sbjct: 213 DDTKAAALLLQND 225


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  164 bits (416), Expect = 1e-40
 Identities = 120/399 (30%), Positives = 190/399 (47%), Gaps = 37/399 (9%)

Query: 19  LHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDE 76
           LH AA   +   ++ LI  G RVN  A++      LH A  +  E+AV++LL+H A V+ 
Sbjct: 45  LHAAAYLGDAEIIELLILSGARVN--AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNA 102

Query: 77  EDA-------VGALTEARLCF----------------GMNALLLSAWFGHLRILQILVNS 113
            D        + A  +A  C                 G  AL  +A+ GH  ++++L++ 
Sbjct: 103 RDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162

Query: 114 GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLD 173
           GA I+   K     +H AA  GH+ V+  ++    +V     DK   T  H AA  G + 
Sbjct: 163 GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK--DKKSYTPLHAAASSGMIS 220

Query: 174 ALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAA 233
            + +L+  G D N  +  GNT LH+A   G   V+  L+D G  + ++N +G T LH AA
Sbjct: 221 VVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAA 280

Query: 234 GGSHPD-CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGA 292
             +H   C++LL+  G+ VN  ++   + LH  AL G    S+ +I +G   +  D  G 
Sbjct: 281 ASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGN 340

Query: 293 SPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNL 352
           +PLH+A R+    L+  LI S +D          PLHLAA   + D    LL +G D++ 
Sbjct: 341 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT 400

Query: 353 RDKQGKTALAVAVRSNHVSLVDMII-------KADRFYR 384
            D  G+T L  A    ++  +++++       K D+F R
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR 439



 Score =  149 bits (377), Expect = 5e-36
 Identities = 111/383 (28%), Positives = 175/383 (45%), Gaps = 27/383 (7%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA   +   ++ L+ R  N  A +   R A+HWAA  GH + V+LL+ H A V  +D
Sbjct: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203

Query: 79  A-----------------------VGALTEARLCFGMNALLLSAWFGHLRILQILVNSGA 115
                                   +G        +G   L ++ + G   ++  L++ GA
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263

Query: 116 KIHCESKDGLTLLHCAAQKGHVPV-LAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA 174
            ++ +++ G T LH AA   H  + L  ++ +  DV +   D  G+T  H  A HG+   
Sbjct: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD--GKTPLHMTALHGRFSR 321

Query: 175 LDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAG 234
              ++ SG   + +DK GNT LH+AA  GH  ++  L+  G D  ++   G+  LH AA 
Sbjct: 322 SQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAAL 381

Query: 235 GSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASP 294
               DC + LL +G  ++       +CLH AA  G+ +   +L++ G   N  D  G SP
Sbjct: 382 SGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441

Query: 295 LHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQ-DIADMLLIAGVDLNLR 353
           LH A  +     +  L+ S + VN +D R  TPLH AA         + LL    +  +R
Sbjct: 442 LHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR 501

Query: 354 DKQGKTALAVAVRSNHVSLVDMI 376
           DKQG  A+  +    H   + +I
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQLI 524



 Score =  141 bits (355), Expect = 2e-33
 Identities = 110/371 (29%), Positives = 179/371 (48%), Gaps = 24/371 (6%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA   +   ++ L+   ++   RN  GR  L  AA  GH + V +L+   A++  +D
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAK---IHCESKDGLTLLHCAAQKG 135
            +   T             +A  GH   L++L+ +      +  +  +G T L  +   G
Sbjct: 614 YILKRTPIHA---------AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664

Query: 136 HVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTA 195
           H   +  ++    +V  D  DK GRTA HR A  G  + +D L+  G    ++D  G T 
Sbjct: 665 HTDCVYSLLNKGANV--DAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 722

Query: 196 LHLAAGRGHMAVLQRLVDIGLDLEEQNA----EGLTALHSAAGGSHPDCVQLLLRAGSTV 251
           +HL+A  GH+ VL  L+     ++   A     G TALH A    H  CV+LLL     V
Sbjct: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLE--QEV 780

Query: 252 NALTQKN-LSCLHYAALSGSEDVSRVLIHAGGCA--NVVDHQGASPLHLAVRHNFPALVR 308
              T+ N  S LH A ++ +E  + +LI   G +  N  D +G +PLH A   +    ++
Sbjct: 781 FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ 840

Query: 309 LLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLL-IAGVDLNLRDKQGKTALAVAVRS 367
           LL++ ++ VN+VD+  +TPL +AAE+   +  +ML+  A  +L L+D    TAL +A   
Sbjct: 841 LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900

Query: 368 NHVSLVDMIIK 378
            H +   +I++
Sbjct: 901 GHETSALLILE 911



 Score =  125 bits (313), Expect = 1e-28
 Identities = 111/408 (27%), Positives = 183/408 (44%), Gaps = 51/408 (12%)

Query: 19  LHEAARQNNVGRMQELIGRR-VNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD-- 75
           LH AA  +  G+  E + R   N   R+  G  A+H++A  GH   ++L+   E  +D  
Sbjct: 475 LHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIAS-ETPLDVL 533

Query: 76  -EEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
            E      L+++     ++ L L+A+ GH + L++LV S   +   +  G T L  AA K
Sbjct: 534 METSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFK 593

Query: 135 GHVPVLAFIMEDLEDVAL-DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHN---VKDK 190
           GHV  +  ++     + + D++  L RT  H AA +G  + L  L+G+    N   ++D 
Sbjct: 594 GHVECVDVLINQGASILVKDYI--LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDG 651

Query: 191 EGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGS- 249
            G T L L+   GH   +  L++ G +++ ++  G TALH  A   H +CV  LL+ G+ 
Sbjct: 652 NGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 711

Query: 250 ----------------------TVNALTQKNLS--------------CLHYAALSGSEDV 273
                                  + AL Q   S               LH+A  +G E  
Sbjct: 712 CLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETC 771

Query: 274 SRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS--DSDVNAVDNRQQTPLHLA 331
             +L+         +    SPLH AV ++      +LI++   S VNA D++ +TPLH A
Sbjct: 772 VELLLEQE-VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAA 830

Query: 332 AEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
           A     +   +LL     +N  D  GKT L +A  +   + V+M++ +
Sbjct: 831 AFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSS 878



 Score =  121 bits (304), Expect = 1e-27
 Identities = 115/409 (28%), Positives = 178/409 (43%), Gaps = 58/409 (14%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AAR  +   +  LI    +T  R   G   LH AA +G     R LL     +D  D
Sbjct: 343 LHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPD 402

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAA------ 132
                      FG   L  +A  G+L  L +L+N+GA  + + K G + LH AA      
Sbjct: 403 D----------FGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQ 452

Query: 133 ----------------QKGHVPVLAFIMEDLEDVALDHV----------DKLGRTAFHRA 166
                           ++G  P+      D +   L+++          DK G  A H +
Sbjct: 453 CLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYS 512

Query: 167 AEHG-----QLDA----LDFLVGSGCDHNVKDKEGNTA---LHLAAGRGHMAVLQRLVDI 214
           A +G     QL A    LD L+ +     + D +       LHLAA  GH   L+ LV  
Sbjct: 513 AAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQS 572

Query: 215 GLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQ-KNLSCLHYAALSGSEDV 273
            LDL+ +N+ G T L  AA   H +CV +L+  G+++         + +H AA +G  + 
Sbjct: 573 LLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSEC 632

Query: 274 SRVLIHAGGCANVVDHQ---GASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHL 330
            R+LI      N VD Q   G +PL L+V +     V  L+N  ++V+A D   +T LH 
Sbjct: 633 LRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHR 692

Query: 331 AAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
            A    ++  D LL  G    LRD +G+T + ++    H+ ++  ++++
Sbjct: 693 GAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQS 741



 Score =  119 bits (298), Expect = 7e-27
 Identities = 88/297 (29%), Positives = 146/297 (49%), Gaps = 3/297 (1%)

Query: 98  SAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDK 157
           +A+ G   I+++L+ SGA+++ +    LT LH A        +  +++   DV  +  DK
Sbjct: 48  AAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADV--NARDK 105

Query: 158 LGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLD 217
             +T  H AA +  +   + LV    + NV D+ G TALH AA  GH  +++ L+  G +
Sbjct: 106 NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165

Query: 218 LEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVL 277
           +   + +   A+H AA   H + V+LL+  G+ V    +K+ + LH AA SG   V + L
Sbjct: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225

Query: 278 IHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQ 337
           +  G   N  +  G +PLH+A  +    +V  LI+  + VN  + +  TPLH AA     
Sbjct: 226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG 285

Query: 338 DIADMLLIA-GVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDP 393
            +   LL+  G D+N++ K GKT L +       S    II++      E  + + P
Sbjct: 286 ALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTP 342



 Score =  116 bits (290), Expect = 6e-26
 Identities = 73/266 (27%), Positives = 129/266 (48%), Gaps = 2/266 (0%)

Query: 107 LQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRA 166
           ++ L+     ++ +  +  T LH AA  G   ++  ++  L    ++  D    T  HRA
Sbjct: 24  VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI--LSGARVNAKDSKWLTPLHRA 81

Query: 167 AEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGL 226
                 +A+  L+    D N +DK   T LH+AA    +   + LV +  ++   +  G 
Sbjct: 82  VASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGR 141

Query: 227 TALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANV 286
           TALH AA   H + V+LLL  G+ +NA  +K+   +H+AA  G  +V ++L+  G     
Sbjct: 142 TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTC 201

Query: 287 VDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIA 346
            D +  +PLH A      ++V+ L++   D+N  +    TPLH+A  +    + + L+  
Sbjct: 202 KDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDC 261

Query: 347 GVDLNLRDKQGKTALAVAVRSNHVSL 372
           G  +N ++++G T L  A  S H +L
Sbjct: 262 GAIVNQKNEKGFTPLHFAAASTHGAL 287



 Score =  108 bits (270), Expect = 1e-23
 Identities = 108/409 (26%), Positives = 171/409 (41%), Gaps = 71/409 (17%)

Query: 22  AARQNNVGRMQELIGRRVNTRARNHV-GRVALHWAAGAGHEQAVRLLL---EHEAAVDEE 77
           AA + +V  +  LI +  +   ++++  R  +H AA  GH + +RLL+   E + AVD +
Sbjct: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ 649

Query: 78  DAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHV 137
           D  G             L+LS   GH   +  L+N GA +  + K G T LH  A  GH 
Sbjct: 650 DGNG----------QTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH- 698

Query: 138 PVLAFIMEDLEDVALDHV------DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVK--- 188
                  E+  D  L H       D  GRT  H +A  G +  L  L+ S    +     
Sbjct: 699 -------EECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAT 751

Query: 189 -DKEGNTALHLAAGRGHMAVLQRLVD---------------------------------I 214
            D  G TALH A   GH   ++ L++                                 +
Sbjct: 752 ADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTL 811

Query: 215 GLDL-EEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDV 273
           G  +    +++G T LH+AA   H +C+QLLL   + VN++     + L  AA +G  + 
Sbjct: 812 GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNT 871

Query: 274 SRVLIHAGGCA-NVVDHQGASPLHLAVRHNFPALVRLLINSDSD---VNAVDNRQQTPLH 329
             +L+ +      + D+   + LHLA          L++   +D   +NA +   QTPLH
Sbjct: 872 VEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLH 931

Query: 330 LAAEHAWQDIADMLLIAGVDLNLRDKQGKT-ALAVAVRSNHVSLVDMII 377
           +AA +    +   LL  G  +   D+ G T ALA A   +    + +I+
Sbjct: 932 VAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980



 Score =  102 bits (254), Expect = 9e-22
 Identities = 69/230 (30%), Positives = 106/230 (46%), Gaps = 2/230 (0%)

Query: 148 EDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAV 207
           EDV     +K  RT  H AA  G  + ++ L+ SG   N KD +  T LH A        
Sbjct: 32  EDVNFQDNEK--RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEA 89

Query: 208 LQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAAL 267
           +Q L+    D+  ++    T LH AA      C + L+   S VN   +   + LH+AA 
Sbjct: 90  VQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAF 149

Query: 268 SGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTP 327
           SG  ++ ++L+  G   N  D +    +H A       +V+LL++  ++V   D +  TP
Sbjct: 150 SGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTP 209

Query: 328 LHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
           LH AA      +   LL  GVD+N  +  G T L VA  +    +V+ +I
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI 259



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 59/213 (27%), Positives = 106/213 (49%)

Query: 165 RAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE 224
           +A  +G  D +  L+    D N +D E  T LH AA  G   +++ L+  G  +  ++++
Sbjct: 14  QAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSK 73

Query: 225 GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284
            LT LH A      + VQ+LL+  + VNA  +   + LH AA + +   +  L+      
Sbjct: 74  WLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNV 133

Query: 285 NVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLL 344
           NV D  G + LH A       +V+LL++  +++NA D + +  +H AA     ++  +L+
Sbjct: 134 NVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV 193

Query: 345 IAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
             G ++  +DK+  T L  A  S  +S+V  ++
Sbjct: 194 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL 226



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 49/150 (32%), Positives = 77/150 (51%)

Query: 228 ALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVV 287
           +L  A     PD V+ L+     VN    +  + LH AA  G  ++  +LI +G   N  
Sbjct: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 288 DHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAG 347
           D +  +PLH AV       V++L+   +DVNA D   QTPLH+AA +     A+ L+   
Sbjct: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130

Query: 348 VDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
            ++N+ D+ G+TAL  A  S H  +V +++
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLL 160



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 29/81 (35%), Positives = 45/81 (55%)

Query: 298 AVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQG 357
           A+ +  P  VR LI    DVN  DN ++TPLH AA     +I ++L+++G  +N +D + 
Sbjct: 15  AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74

Query: 358 KTALAVAVRSNHVSLVDMIIK 378
            T L  AV S     V +++K
Sbjct: 75  LTPLHRAVASCSEEAVQVLLK 95


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  157 bits (396), Expect = 3e-38
 Identities = 112/362 (30%), Positives = 165/362 (45%), Gaps = 12/362 (3%)

Query: 15  LERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           +E  LH AAR  +    + L+  +    A+    +  LH AA  GH   V+LLLE+ A  
Sbjct: 470 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529

Query: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
           +     G             L ++A  GH+  +  L+   A   C +K G T LH AA+ 
Sbjct: 530 NLATTAGH----------TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKY 579

Query: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNT 194
           G V V   ++E   D   +   K G T  H A  H  LD +  L+  G   +     G T
Sbjct: 580 GKVRVAELLLE--RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 637

Query: 195 ALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNAL 254
            LH+AA +  + V + L+  G     ++ +G+T LH AA   H + V LLL   +  N  
Sbjct: 638 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 697

Query: 255 TQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSD 314
            +  L+ LH  A  G   V+ VLI  G   +     G +PLH+A  +    LV+ L+   
Sbjct: 698 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 757

Query: 315 SDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVD 374
           +DVNA      +PLH AA+    DI  +LL  G   N     G T LA+A R  ++S+ D
Sbjct: 758 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 817

Query: 375 MI 376
           ++
Sbjct: 818 VL 819



 Score =  154 bits (388), Expect = 2e-37
 Identities = 115/410 (28%), Positives = 191/410 (46%), Gaps = 23/410 (5%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A ++N+V  M+ L+    +  A    G   LH A+  GH   V+ LL+  A+ +  +
Sbjct: 408 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 467

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                           L ++A  GH  + + L+ + AK++ ++KD  T LHCAA+ GH  
Sbjct: 468 VKVE----------TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           ++  ++E+  +  L      G T  H AA  G ++ +  L+          K+G T LH+
Sbjct: 518 MVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 575

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  G + V + L++           GLT LH A   ++ D V+LLL  G + ++     
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
            + LH AA     +V+R L+  GG AN    QG +PLHLA +     +V LL++  ++ N
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
             +    TPLHL A+     +AD+L+  GV ++   + G T L VA    ++ LV  +++
Sbjct: 696 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755

Query: 379 ADRFYRWEKDHPSDPSGKS-LSFKQDHRQETQQLRSVLWRLASRYLQPRE 427
                     H +D + K+ L +   H+   Q    ++  L      P E
Sbjct: 756 ----------HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 795



 Score =  152 bits (385), Expect = 5e-37
 Identities = 106/360 (29%), Positives = 178/360 (49%), Gaps = 16/360 (4%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A+++ +V  + EL+ + +        G  ALH AA AG ++ VR L+ +        
Sbjct: 82  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNY-------- 133

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L ++A   HL +++ L+ +GA  +  ++DG T L  A Q+GH  
Sbjct: 134 --GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 191

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           V+A +      +      K+   A H AA +        L+ +  + +V  K G T LH+
Sbjct: 192 VVAHL------INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI 245

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA   ++ V Q L++ G  +      G+T LH A+   +   V+LLL  G+ +   T+  
Sbjct: 246 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 305

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           L+ LH AA +G   +S +L+  G         G SP+H+A + +    VRLL+  D++++
Sbjct: 306 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
            +     TPLH+AA      +A +LL  G   N R   G T L +A + NHV ++++++K
Sbjct: 366 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 425



 Score =  152 bits (383), Expect = 9e-37
 Identities = 124/445 (27%), Positives = 202/445 (45%), Gaps = 33/445 (7%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA   N+   Q L+ R  +       G   LH A+  G+   VRLLL+         
Sbjct: 243 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-------- 294

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA  E +    +  L  +A  GH+RI +IL++ GA I  ++K+GL+ +H AAQ  H+ 
Sbjct: 295 --GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 352

Query: 139 VLAFIME---DLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTA 195
            +  +++   +++D+ LDH+     T  H AA  G       L+  G   N +   G T 
Sbjct: 353 CVRLLLQYDAEIDDITLDHL-----TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 407

Query: 196 LHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALT 255
           LH+A  + H+ V++ L+  G  ++     GLT LH A+   H   V+ LL+ G++ N   
Sbjct: 408 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 467

Query: 256 QKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDS 315
            K  + LH AA +G  +V++ L+      N       +PLH A R     +V+LL+ +++
Sbjct: 468 VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 527

Query: 316 DVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDM 375
           + N       TPLH+AA     +    LL          K+G T L VA +   V + ++
Sbjct: 528 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 587

Query: 376 IIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSVLWRLASRYLQPREWKKLAYSW 435
           +++ D        HP + +GK+             L  V      + L PR     + +W
Sbjct: 588 LLERDA-------HP-NAAGKNGLTPLHVAVHHNNLDIV------KLLLPRGGSPHSPAW 633

Query: 436 E-FTEAHVDAIEQQWTGTRSYQEHG 459
             +T  H+ A + Q    RS  ++G
Sbjct: 634 NGYTPLHIAAKQNQVEVARSLLQYG 658



 Score =  150 bits (378), Expect = 4e-36
 Identities = 105/362 (29%), Positives = 178/362 (49%), Gaps = 12/362 (3%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AAR ++      L+    N    +  G   LH AA   +    +LLL   A+V+   
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN--- 266

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                T      G+  L +++  G++ ++++L++ GA+I  ++KD LT LHCAA+ GHV 
Sbjct: 267 ----FTPQN---GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 319

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           +   +++      +    K G +  H AA+   LD +  L+    + +    +  T LH+
Sbjct: 320 ISEILLD--HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 377

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  GH  V + L+D G     +   G T LH A   +H   ++LLL+ G++++A+T+  
Sbjct: 378 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 437

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           L+ LH A+  G   + + L+  G   NV + +  +PLH+A R     + + L+ + + VN
Sbjct: 438 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 497

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
           A     QTPLH AA     ++  +LL    + NL    G T L +A R  HV  V  +++
Sbjct: 498 AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 557

Query: 379 AD 380
            +
Sbjct: 558 KE 559



 Score =  122 bits (306), Expect = 8e-28
 Identities = 93/359 (25%), Positives = 162/359 (45%), Gaps = 49/359 (13%)

Query: 22  AARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVG 81
           AAR  N+ +  + +   V+    N  G   LH A+  GH + V  LL  E          
Sbjct: 52  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI--------- 102

Query: 82  ALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLA 141
            + E     G  AL ++A  G   +++ LVN GA ++ +S+ G T L+ AAQ+ H     
Sbjct: 103 -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH----- 156

Query: 142 FIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAG 201
                                         L+ + FL+ +G + NV  ++G T L +A  
Sbjct: 157 ------------------------------LEVVKFLLENGANQNVATEDGFTPLAVALQ 186

Query: 202 RGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSC 261
           +GH  V+  L++ G     +    L ALH AA         +LL+     + L++   + 
Sbjct: 187 QGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 242

Query: 262 LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVD 321
           LH AA   + +V+++L++ G   N     G +PLH+A R     +VRLL++  + +    
Sbjct: 243 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 302

Query: 322 NRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKAD 380
             + TPLH AA +    I+++LL  G  +  + K G + + +A + +H+  V ++++ D
Sbjct: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 361



 Score =  102 bits (253), Expect = 1e-21
 Identities = 74/247 (29%), Positives = 118/247 (47%), Gaps = 31/247 (12%)

Query: 161 TAFHRAAEHGQLD-ALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 219
           T+F RAA  G LD ALD L  +G D N  ++ G   LHLA+  GH+ ++  L+   + LE
Sbjct: 47  TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 105

Query: 220 EQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
               +G TALH AA     + V+ L+  G+ VNA +QK  + L+ AA     +V + L+ 
Sbjct: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165

Query: 280 AGGCANVVDHQGASP-----------------------------LHLAVRHNFPALVRLL 310
            G   NV    G +P                             LH+A R++      +L
Sbjct: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 225

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           + +D + + +     TPLH+AA +   ++A +LL  G  +N   + G T L +A R  +V
Sbjct: 226 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 285

Query: 371 SLVDMII 377
            +V +++
Sbjct: 286 IMVRLLL 292



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 46/158 (29%), Positives = 77/158 (48%)

Query: 220 EQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
           ++ A+  T+   AA   + D     LR G  +N   Q  L+ LH A+  G   +   L+H
Sbjct: 40  KKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 99

Query: 280 AGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDI 339
                     +G + LH+A       +VR L+N  ++VNA   +  TPL++AA+    ++
Sbjct: 100 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 159

Query: 340 ADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
              LL  G + N+  + G T LAVA++  H ++V  +I
Sbjct: 160 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 197


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  157 bits (396), Expect = 3e-38
 Identities = 112/362 (30%), Positives = 165/362 (45%), Gaps = 12/362 (3%)

Query: 15  LERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           +E  LH AAR  +    + L+  +    A+    +  LH AA  GH   V+LLLE+ A  
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
           +     G             L ++A  GH+  +  L+   A   C +K G T LH AA+ 
Sbjct: 497 NLATTAGH----------TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKY 546

Query: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNT 194
           G V V   ++E   D   +   K G T  H A  H  LD +  L+  G   +     G T
Sbjct: 547 GKVRVAELLLE--RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604

Query: 195 ALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNAL 254
            LH+AA +  + V + L+  G     ++ +G+T LH AA   H + V LLL   +  N  
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 255 TQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSD 314
            +  L+ LH  A  G   V+ VLI  G   +     G +PLH+A  +    LV+ L+   
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724

Query: 315 SDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVD 374
           +DVNA      +PLH AA+    DI  +LL  G   N     G T LA+A R  ++S+ D
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784

Query: 375 MI 376
           ++
Sbjct: 785 VL 786



 Score =  154 bits (388), Expect = 2e-37
 Identities = 115/410 (28%), Positives = 191/410 (46%), Gaps = 23/410 (5%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A ++N+V  M+ L+    +  A    G   LH A+  GH   V+ LL+  A+ +  +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                           L ++A  GH  + + L+ + AK++ ++KD  T LHCAA+ GH  
Sbjct: 435 VKVE----------TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           ++  ++E+  +  L      G T  H AA  G ++ +  L+          K+G T LH+
Sbjct: 485 MVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  G + V + L++           GLT LH A   ++ D V+LLL  G + ++     
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
            + LH AA     +V+R L+  GG AN    QG +PLHLA +     +V LL++  ++ N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
             +    TPLHL A+     +AD+L+  GV ++   + G T L VA    ++ LV  +++
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722

Query: 379 ADRFYRWEKDHPSDPSGKS-LSFKQDHRQETQQLRSVLWRLASRYLQPRE 427
                     H +D + K+ L +   H+   Q    ++  L      P E
Sbjct: 723 ----------HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762



 Score =  152 bits (385), Expect = 5e-37
 Identities = 106/360 (29%), Positives = 178/360 (49%), Gaps = 16/360 (4%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A+++ +V  + EL+ + +        G  ALH AA AG ++ VR L+ +        
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNY-------- 100

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L ++A   HL +++ L+ +GA  +  ++DG T L  A Q+GH  
Sbjct: 101 --GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 158

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           V+A +      +      K+   A H AA +        L+ +  + +V  K G T LH+
Sbjct: 159 VVAHL------INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI 212

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA   ++ V Q L++ G  +      G+T LH A+   +   V+LLL  G+ +   T+  
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           L+ LH AA +G   +S +L+  G         G SP+H+A + +    VRLL+  D++++
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
            +     TPLH+AA      +A +LL  G   N R   G T L +A + NHV ++++++K
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392



 Score =  152 bits (383), Expect = 9e-37
 Identities = 124/445 (27%), Positives = 202/445 (45%), Gaps = 33/445 (7%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA   N+   Q L+ R  +       G   LH A+  G+   VRLLL+         
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-------- 261

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA  E +    +  L  +A  GH+RI +IL++ GA I  ++K+GL+ +H AAQ  H+ 
Sbjct: 262 --GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319

Query: 139 VLAFIME---DLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTA 195
            +  +++   +++D+ LDH+     T  H AA  G       L+  G   N +   G T 
Sbjct: 320 CVRLLLQYDAEIDDITLDHL-----TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 374

Query: 196 LHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALT 255
           LH+A  + H+ V++ L+  G  ++     GLT LH A+   H   V+ LL+ G++ N   
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 256 QKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDS 315
            K  + LH AA +G  +V++ L+      N       +PLH A R     +V+LL+ +++
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494

Query: 316 DVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDM 375
           + N       TPLH+AA     +    LL          K+G T L VA +   V + ++
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554

Query: 376 IIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSVLWRLASRYLQPREWKKLAYSW 435
           +++ D        HP + +GK+             L  V      + L PR     + +W
Sbjct: 555 LLERDA-------HP-NAAGKNGLTPLHVAVHHNNLDIV------KLLLPRGGSPHSPAW 600

Query: 436 E-FTEAHVDAIEQQWTGTRSYQEHG 459
             +T  H+ A + Q    RS  ++G
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYG 625



 Score =  150 bits (378), Expect = 4e-36
 Identities = 105/362 (29%), Positives = 178/362 (49%), Gaps = 12/362 (3%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AAR ++      L+    N    +  G   LH AA   +    +LLL   A+V+   
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN--- 233

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                T      G+  L +++  G++ ++++L++ GA+I  ++KD LT LHCAA+ GHV 
Sbjct: 234 ----FTPQN---GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           +   +++      +    K G +  H AA+   LD +  L+    + +    +  T LH+
Sbjct: 287 ISEILLD--HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  GH  V + L+D G     +   G T LH A   +H   ++LLL+ G++++A+T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           L+ LH A+  G   + + L+  G   NV + +  +PLH+A R     + + L+ + + VN
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
           A     QTPLH AA     ++  +LL    + NL    G T L +A R  HV  V  +++
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524

Query: 379 AD 380
            +
Sbjct: 525 KE 526



 Score =  122 bits (306), Expect = 8e-28
 Identities = 93/359 (25%), Positives = 162/359 (45%), Gaps = 49/359 (13%)

Query: 22  AARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVG 81
           AAR  N+ +  + +   V+    N  G   LH A+  GH + V  LL  E          
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI--------- 69

Query: 82  ALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLA 141
            + E     G  AL ++A  G   +++ LVN GA ++ +S+ G T L+ AAQ+ H     
Sbjct: 70  -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH----- 123

Query: 142 FIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAG 201
                                         L+ + FL+ +G + NV  ++G T L +A  
Sbjct: 124 ------------------------------LEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 202 RGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSC 261
           +GH  V+  L++ G     +    L ALH AA         +LL+     + L++   + 
Sbjct: 154 QGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209

Query: 262 LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVD 321
           LH AA   + +V+++L++ G   N     G +PLH+A R     +VRLL++  + +    
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269

Query: 322 NRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKAD 380
             + TPLH AA +    I+++LL  G  +  + K G + + +A + +H+  V ++++ D
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328



 Score =  102 bits (253), Expect = 1e-21
 Identities = 74/247 (29%), Positives = 118/247 (47%), Gaps = 31/247 (12%)

Query: 161 TAFHRAAEHGQLD-ALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 219
           T+F RAA  G LD ALD L  +G D N  ++ G   LHLA+  GH+ ++  L+   + LE
Sbjct: 14  TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 220 EQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
               +G TALH AA     + V+ L+  G+ VNA +QK  + L+ AA     +V + L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 280 AGGCANVVDHQGASP-----------------------------LHLAVRHNFPALVRLL 310
            G   NV    G +P                             LH+A R++      +L
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           + +D + + +     TPLH+AA +   ++A +LL  G  +N   + G T L +A R  +V
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 371 SLVDMII 377
            +V +++
Sbjct: 253 IMVRLLL 259



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 46/157 (29%), Positives = 76/157 (48%)

Query: 221 QNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHA 280
           + A+  T+   AA   + D     LR G  +N   Q  L+ LH A+  G   +   L+H 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 281 GGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIA 340
                    +G + LH+A       +VR L+N  ++VNA   +  TPL++AA+    ++ 
Sbjct: 68  EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 341 DMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
             LL  G + N+  + G T LAVA++  H ++V  +I
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  157 bits (396), Expect = 3e-38
 Identities = 112/362 (30%), Positives = 165/362 (45%), Gaps = 12/362 (3%)

Query: 15  LERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           +E  LH AAR  +    + L+  +    A+    +  LH AA  GH   V+LLLE+ A  
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
           +     G             L ++A  GH+  +  L+   A   C +K G T LH AA+ 
Sbjct: 497 NLATTAGH----------TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKY 546

Query: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNT 194
           G V V   ++E   D   +   K G T  H A  H  LD +  L+  G   +     G T
Sbjct: 547 GKVRVAELLLE--RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604

Query: 195 ALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNAL 254
            LH+AA +  + V + L+  G     ++ +G+T LH AA   H + V LLL   +  N  
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 255 TQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSD 314
            +  L+ LH  A  G   V+ VLI  G   +     G +PLH+A  +    LV+ L+   
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724

Query: 315 SDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVD 374
           +DVNA      +PLH AA+    DI  +LL  G   N     G T LA+A R  ++S+ D
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784

Query: 375 MI 376
           ++
Sbjct: 785 VL 786



 Score =  154 bits (388), Expect = 2e-37
 Identities = 115/410 (28%), Positives = 191/410 (46%), Gaps = 23/410 (5%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A ++N+V  M+ L+    +  A    G   LH A+  GH   V+ LL+  A+ +  +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                           L ++A  GH  + + L+ + AK++ ++KD  T LHCAA+ GH  
Sbjct: 435 VKVE----------TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           ++  ++E+  +  L      G T  H AA  G ++ +  L+          K+G T LH+
Sbjct: 485 MVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  G + V + L++           GLT LH A   ++ D V+LLL  G + ++     
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
            + LH AA     +V+R L+  GG AN    QG +PLHLA +     +V LL++  ++ N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
             +    TPLHL A+     +AD+L+  GV ++   + G T L VA    ++ LV  +++
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722

Query: 379 ADRFYRWEKDHPSDPSGKS-LSFKQDHRQETQQLRSVLWRLASRYLQPRE 427
                     H +D + K+ L +   H+   Q    ++  L      P E
Sbjct: 723 ----------HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762



 Score =  152 bits (385), Expect = 5e-37
 Identities = 106/360 (29%), Positives = 178/360 (49%), Gaps = 16/360 (4%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A+++ +V  + EL+ + +        G  ALH AA AG ++ VR L+ +        
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNY-------- 100

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L ++A   HL +++ L+ +GA  +  ++DG T L  A Q+GH  
Sbjct: 101 --GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 158

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           V+A +      +      K+   A H AA +        L+ +  + +V  K G T LH+
Sbjct: 159 VVAHL------INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI 212

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA   ++ V Q L++ G  +      G+T LH A+   +   V+LLL  G+ +   T+  
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           L+ LH AA +G   +S +L+  G         G SP+H+A + +    VRLL+  D++++
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
            +     TPLH+AA      +A +LL  G   N R   G T L +A + NHV ++++++K
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392



 Score =  152 bits (383), Expect = 9e-37
 Identities = 124/445 (27%), Positives = 202/445 (45%), Gaps = 33/445 (7%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA   N+   Q L+ R  +       G   LH A+  G+   VRLLL+         
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-------- 261

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA  E +    +  L  +A  GH+RI +IL++ GA I  ++K+GL+ +H AAQ  H+ 
Sbjct: 262 --GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319

Query: 139 VLAFIME---DLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTA 195
            +  +++   +++D+ LDH+     T  H AA  G       L+  G   N +   G T 
Sbjct: 320 CVRLLLQYDAEIDDITLDHL-----TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 374

Query: 196 LHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALT 255
           LH+A  + H+ V++ L+  G  ++     GLT LH A+   H   V+ LL+ G++ N   
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 256 QKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDS 315
            K  + LH AA +G  +V++ L+      N       +PLH A R     +V+LL+ +++
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494

Query: 316 DVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDM 375
           + N       TPLH+AA     +    LL          K+G T L VA +   V + ++
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554

Query: 376 IIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSVLWRLASRYLQPREWKKLAYSW 435
           +++ D        HP + +GK+             L  V      + L PR     + +W
Sbjct: 555 LLERDA-------HP-NAAGKNGLTPLHVAVHHNNLDIV------KLLLPRGGSPHSPAW 600

Query: 436 E-FTEAHVDAIEQQWTGTRSYQEHG 459
             +T  H+ A + Q    RS  ++G
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYG 625



 Score =  150 bits (378), Expect = 4e-36
 Identities = 105/362 (29%), Positives = 178/362 (49%), Gaps = 12/362 (3%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AAR ++      L+    N    +  G   LH AA   +    +LLL   A+V+   
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN--- 233

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                T      G+  L +++  G++ ++++L++ GA+I  ++KD LT LHCAA+ GHV 
Sbjct: 234 ----FTPQN---GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           +   +++      +    K G +  H AA+   LD +  L+    + +    +  T LH+
Sbjct: 287 ISEILLD--HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  GH  V + L+D G     +   G T LH A   +H   ++LLL+ G++++A+T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           L+ LH A+  G   + + L+  G   NV + +  +PLH+A R     + + L+ + + VN
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
           A     QTPLH AA     ++  +LL    + NL    G T L +A R  HV  V  +++
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524

Query: 379 AD 380
            +
Sbjct: 525 KE 526



 Score =  122 bits (306), Expect = 8e-28
 Identities = 93/359 (25%), Positives = 162/359 (45%), Gaps = 49/359 (13%)

Query: 22  AARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVG 81
           AAR  N+ +  + +   V+    N  G   LH A+  GH + V  LL  E          
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI--------- 69

Query: 82  ALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLA 141
            + E     G  AL ++A  G   +++ LVN GA ++ +S+ G T L+ AAQ+ H     
Sbjct: 70  -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH----- 123

Query: 142 FIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAG 201
                                         L+ + FL+ +G + NV  ++G T L +A  
Sbjct: 124 ------------------------------LEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 202 RGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSC 261
           +GH  V+  L++ G     +    L ALH AA         +LL+     + L++   + 
Sbjct: 154 QGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209

Query: 262 LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVD 321
           LH AA   + +V+++L++ G   N     G +PLH+A R     +VRLL++  + +    
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269

Query: 322 NRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKAD 380
             + TPLH AA +    I+++LL  G  +  + K G + + +A + +H+  V ++++ D
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328



 Score =  102 bits (253), Expect = 1e-21
 Identities = 74/247 (29%), Positives = 118/247 (47%), Gaps = 31/247 (12%)

Query: 161 TAFHRAAEHGQLD-ALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 219
           T+F RAA  G LD ALD L  +G D N  ++ G   LHLA+  GH+ ++  L+   + LE
Sbjct: 14  TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 220 EQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
               +G TALH AA     + V+ L+  G+ VNA +QK  + L+ AA     +V + L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 280 AGGCANVVDHQGASP-----------------------------LHLAVRHNFPALVRLL 310
            G   NV    G +P                             LH+A R++      +L
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           + +D + + +     TPLH+AA +   ++A +LL  G  +N   + G T L +A R  +V
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 371 SLVDMII 377
            +V +++
Sbjct: 253 IMVRLLL 259



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 46/157 (29%), Positives = 76/157 (48%)

Query: 221 QNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHA 280
           + A+  T+   AA   + D     LR G  +N   Q  L+ LH A+  G   +   L+H 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 281 GGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIA 340
                    +G + LH+A       +VR L+N  ++VNA   +  TPL++AA+    ++ 
Sbjct: 68  EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 341 DMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
             LL  G + N+  + G T LAVA++  H ++V  +I
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  157 bits (396), Expect = 3e-38
 Identities = 112/362 (30%), Positives = 165/362 (45%), Gaps = 12/362 (3%)

Query: 15  LERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           +E  LH AAR  +    + L+  +    A+    +  LH AA  GH   V+LLLE+ A  
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
           +     G             L ++A  GH+  +  L+   A   C +K G T LH AA+ 
Sbjct: 497 NLATTAGH----------TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKY 546

Query: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNT 194
           G V V   ++E   D   +   K G T  H A  H  LD +  L+  G   +     G T
Sbjct: 547 GKVRVAELLLE--RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604

Query: 195 ALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNAL 254
            LH+AA +  + V + L+  G     ++ +G+T LH AA   H + V LLL   +  N  
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 255 TQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSD 314
            +  L+ LH  A  G   V+ VLI  G   +     G +PLH+A  +    LV+ L+   
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724

Query: 315 SDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVD 374
           +DVNA      +PLH AA+    DI  +LL  G   N     G T LA+A R  ++S+ D
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784

Query: 375 MI 376
           ++
Sbjct: 785 VL 786



 Score =  154 bits (388), Expect = 2e-37
 Identities = 115/410 (28%), Positives = 191/410 (46%), Gaps = 23/410 (5%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A ++N+V  M+ L+    +  A    G   LH A+  GH   V+ LL+  A+ +  +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                           L ++A  GH  + + L+ + AK++ ++KD  T LHCAA+ GH  
Sbjct: 435 VKVE----------TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           ++  ++E+  +  L      G T  H AA  G ++ +  L+          K+G T LH+
Sbjct: 485 MVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  G + V + L++           GLT LH A   ++ D V+LLL  G + ++     
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
            + LH AA     +V+R L+  GG AN    QG +PLHLA +     +V LL++  ++ N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
             +    TPLHL A+     +AD+L+  GV ++   + G T L VA    ++ LV  +++
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722

Query: 379 ADRFYRWEKDHPSDPSGKS-LSFKQDHRQETQQLRSVLWRLASRYLQPRE 427
                     H +D + K+ L +   H+   Q    ++  L      P E
Sbjct: 723 ----------HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762



 Score =  152 bits (385), Expect = 5e-37
 Identities = 106/360 (29%), Positives = 178/360 (49%), Gaps = 16/360 (4%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A+++ +V  + EL+ + +        G  ALH AA AG ++ VR L+ +        
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNY-------- 100

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L ++A   HL +++ L+ +GA  +  ++DG T L  A Q+GH  
Sbjct: 101 --GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 158

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           V+A +      +      K+   A H AA +        L+ +  + +V  K G T LH+
Sbjct: 159 VVAHL------INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI 212

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA   ++ V Q L++ G  +      G+T LH A+   +   V+LLL  G+ +   T+  
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           L+ LH AA +G   +S +L+  G         G SP+H+A + +    VRLL+  D++++
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
            +     TPLH+AA      +A +LL  G   N R   G T L +A + NHV ++++++K
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392



 Score =  152 bits (383), Expect = 9e-37
 Identities = 124/445 (27%), Positives = 202/445 (45%), Gaps = 33/445 (7%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA   N+   Q L+ R  +       G   LH A+  G+   VRLLL+         
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-------- 261

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA  E +    +  L  +A  GH+RI +IL++ GA I  ++K+GL+ +H AAQ  H+ 
Sbjct: 262 --GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319

Query: 139 VLAFIME---DLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTA 195
            +  +++   +++D+ LDH+     T  H AA  G       L+  G   N +   G T 
Sbjct: 320 CVRLLLQYDAEIDDITLDHL-----TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 374

Query: 196 LHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALT 255
           LH+A  + H+ V++ L+  G  ++     GLT LH A+   H   V+ LL+ G++ N   
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 256 QKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDS 315
            K  + LH AA +G  +V++ L+      N       +PLH A R     +V+LL+ +++
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494

Query: 316 DVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDM 375
           + N       TPLH+AA     +    LL          K+G T L VA +   V + ++
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554

Query: 376 IIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSVLWRLASRYLQPREWKKLAYSW 435
           +++ D        HP + +GK+             L  V      + L PR     + +W
Sbjct: 555 LLERDA-------HP-NAAGKNGLTPLHVAVHHNNLDIV------KLLLPRGGSPHSPAW 600

Query: 436 E-FTEAHVDAIEQQWTGTRSYQEHG 459
             +T  H+ A + Q    RS  ++G
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYG 625



 Score =  150 bits (378), Expect = 4e-36
 Identities = 105/362 (29%), Positives = 178/362 (49%), Gaps = 12/362 (3%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AAR ++      L+    N    +  G   LH AA   +    +LLL   A+V+   
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN--- 233

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                T      G+  L +++  G++ ++++L++ GA+I  ++KD LT LHCAA+ GHV 
Sbjct: 234 ----FTPQN---GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           +   +++      +    K G +  H AA+   LD +  L+    + +    +  T LH+
Sbjct: 287 ISEILLD--HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  GH  V + L+D G     +   G T LH A   +H   ++LLL+ G++++A+T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           L+ LH A+  G   + + L+  G   NV + +  +PLH+A R     + + L+ + + VN
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
           A     QTPLH AA     ++  +LL    + NL    G T L +A R  HV  V  +++
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524

Query: 379 AD 380
            +
Sbjct: 525 KE 526



 Score =  122 bits (306), Expect = 8e-28
 Identities = 93/359 (25%), Positives = 162/359 (45%), Gaps = 49/359 (13%)

Query: 22  AARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVG 81
           AAR  N+ +  + +   V+    N  G   LH A+  GH + V  LL  E          
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI--------- 69

Query: 82  ALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLA 141
            + E     G  AL ++A  G   +++ LVN GA ++ +S+ G T L+ AAQ+ H     
Sbjct: 70  -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH----- 123

Query: 142 FIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAG 201
                                         L+ + FL+ +G + NV  ++G T L +A  
Sbjct: 124 ------------------------------LEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 202 RGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSC 261
           +GH  V+  L++ G     +    L ALH AA         +LL+     + L++   + 
Sbjct: 154 QGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209

Query: 262 LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVD 321
           LH AA   + +V+++L++ G   N     G +PLH+A R     +VRLL++  + +    
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269

Query: 322 NRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKAD 380
             + TPLH AA +    I+++LL  G  +  + K G + + +A + +H+  V ++++ D
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328



 Score =  102 bits (253), Expect = 1e-21
 Identities = 74/247 (29%), Positives = 118/247 (47%), Gaps = 31/247 (12%)

Query: 161 TAFHRAAEHGQLD-ALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 219
           T+F RAA  G LD ALD L  +G D N  ++ G   LHLA+  GH+ ++  L+   + LE
Sbjct: 14  TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 220 EQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
               +G TALH AA     + V+ L+  G+ VNA +QK  + L+ AA     +V + L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 280 AGGCANVVDHQGASP-----------------------------LHLAVRHNFPALVRLL 310
            G   NV    G +P                             LH+A R++      +L
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           + +D + + +     TPLH+AA +   ++A +LL  G  +N   + G T L +A R  +V
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 371 SLVDMII 377
            +V +++
Sbjct: 253 IMVRLLL 259



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 46/157 (29%), Positives = 76/157 (48%)

Query: 221 QNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHA 280
           + A+  T+   AA   + D     LR G  +N   Q  L+ LH A+  G   +   L+H 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 281 GGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIA 340
                    +G + LH+A       +VR L+N  ++VNA   +  TPL++AA+    ++ 
Sbjct: 68  EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 341 DMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
             LL  G + N+  + G T LAVA++  H ++V  +I
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  157 bits (396), Expect = 3e-38
 Identities = 112/362 (30%), Positives = 165/362 (45%), Gaps = 12/362 (3%)

Query: 15  LERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           +E  LH AAR  +    + L+  +    A+    +  LH AA  GH   V+LLLE+ A  
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
           +     G             L ++A  GH+  +  L+   A   C +K G T LH AA+ 
Sbjct: 497 NLATTAGH----------TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKY 546

Query: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNT 194
           G V V   ++E   D   +   K G T  H A  H  LD +  L+  G   +     G T
Sbjct: 547 GKVRVAELLLE--RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT 604

Query: 195 ALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNAL 254
            LH+AA +  + V + L+  G     ++ +G+T LH AA   H + V LLL   +  N  
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 255 TQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSD 314
            +  L+ LH  A  G   V+ VLI  G   +     G +PLH+A  +    LV+ L+   
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724

Query: 315 SDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVD 374
           +DVNA      +PLH AA+    DI  +LL  G   N     G T LA+A R  ++S+ D
Sbjct: 725 ADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784

Query: 375 MI 376
           ++
Sbjct: 785 VL 786



 Score =  154 bits (388), Expect = 2e-37
 Identities = 115/410 (28%), Positives = 191/410 (46%), Gaps = 23/410 (5%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A ++N+V  M+ L+    +  A    G   LH A+  GH   V+ LL+  A+ +  +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                           L ++A  GH  + + L+ + AK++ ++KD  T LHCAA+ GH  
Sbjct: 435 VKVE----------TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           ++  ++E+  +  L      G T  H AA  G ++ +  L+          K+G T LH+
Sbjct: 485 MVKLLLENNANPNL--ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  G + V + L++           GLT LH A   ++ D V+LLL  G + ++     
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
            + LH AA     +V+R L+  GG AN    QG +PLHLA +     +V LL++  ++ N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
             +    TPLHL A+     +AD+L+  GV ++   + G T L VA    ++ LV  +++
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722

Query: 379 ADRFYRWEKDHPSDPSGKS-LSFKQDHRQETQQLRSVLWRLASRYLQPRE 427
                     H +D + K+ L +   H+   Q    ++  L      P E
Sbjct: 723 ----------HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762



 Score =  152 bits (385), Expect = 5e-37
 Identities = 106/360 (29%), Positives = 178/360 (49%), Gaps = 16/360 (4%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A+++ +V  + EL+ + +        G  ALH AA AG ++ VR L+ +        
Sbjct: 49  LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNY-------- 100

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L ++A   HL +++ L+ +GA  +  ++DG T L  A Q+GH  
Sbjct: 101 --GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 158

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           V+A +      +      K+   A H AA +        L+ +  + +V  K G T LH+
Sbjct: 159 VVAHL------INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI 212

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA   ++ V Q L++ G  +      G+T LH A+   +   V+LLL  G+ +   T+  
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           L+ LH AA +G   +S +L+  G         G SP+H+A + +    VRLL+  D++++
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
            +     TPLH+AA      +A +LL  G   N R   G T L +A + NHV ++++++K
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392



 Score =  152 bits (383), Expect = 9e-37
 Identities = 124/445 (27%), Positives = 202/445 (45%), Gaps = 33/445 (7%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA   N+   Q L+ R  +       G   LH A+  G+   VRLLL+         
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-------- 261

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA  E +    +  L  +A  GH+RI +IL++ GA I  ++K+GL+ +H AAQ  H+ 
Sbjct: 262 --GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319

Query: 139 VLAFIME---DLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTA 195
            +  +++   +++D+ LDH+     T  H AA  G       L+  G   N +   G T 
Sbjct: 320 CVRLLLQYDAEIDDITLDHL-----TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 374

Query: 196 LHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALT 255
           LH+A  + H+ V++ L+  G  ++     GLT LH A+   H   V+ LL+ G++ N   
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434

Query: 256 QKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDS 315
            K  + LH AA +G  +V++ L+      N       +PLH A R     +V+LL+ +++
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494

Query: 316 DVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDM 375
           + N       TPLH+AA     +    LL          K+G T L VA +   V + ++
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554

Query: 376 IIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSVLWRLASRYLQPREWKKLAYSW 435
           +++ D        HP + +GK+             L  V      + L PR     + +W
Sbjct: 555 LLERDA-------HP-NAAGKNGLTPLHVAVHHNNLDIV------KLLLPRGGSPHSPAW 600

Query: 436 E-FTEAHVDAIEQQWTGTRSYQEHG 459
             +T  H+ A + Q    RS  ++G
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYG 625



 Score =  150 bits (378), Expect = 4e-36
 Identities = 105/362 (29%), Positives = 178/362 (49%), Gaps = 12/362 (3%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AAR ++      L+    N    +  G   LH AA   +    +LLL   A+V+   
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN--- 233

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                T      G+  L +++  G++ ++++L++ GA+I  ++KD LT LHCAA+ GHV 
Sbjct: 234 ----FTPQN---GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           +   +++      +    K G +  H AA+   LD +  L+    + +    +  T LH+
Sbjct: 287 ISEILLD--HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHV 344

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  GH  V + L+D G     +   G T LH A   +H   ++LLL+ G++++A+T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           L+ LH A+  G   + + L+  G   NV + +  +PLH+A R     + + L+ + + VN
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
           A     QTPLH AA     ++  +LL    + NL    G T L +A R  HV  V  +++
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524

Query: 379 AD 380
            +
Sbjct: 525 KE 526



 Score =  122 bits (306), Expect = 8e-28
 Identities = 93/359 (25%), Positives = 162/359 (45%), Gaps = 49/359 (13%)

Query: 22  AARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVG 81
           AAR  N+ +  + +   V+    N  G   LH A+  GH + V  LL  E          
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI--------- 69

Query: 82  ALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLA 141
            + E     G  AL ++A  G   +++ LVN GA ++ +S+ G T L+ AAQ+ H     
Sbjct: 70  -ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH----- 123

Query: 142 FIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAG 201
                                         L+ + FL+ +G + NV  ++G T L +A  
Sbjct: 124 ------------------------------LEVVKFLLENGANQNVATEDGFTPLAVALQ 153

Query: 202 RGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSC 261
           +GH  V+  L++ G     +    L ALH AA         +LL+     + L++   + 
Sbjct: 154 QGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 209

Query: 262 LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVD 321
           LH AA   + +V+++L++ G   N     G +PLH+A R     +VRLL++  + +    
Sbjct: 210 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 269

Query: 322 NRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKAD 380
             + TPLH AA +    I+++LL  G  +  + K G + + +A + +H+  V ++++ D
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328



 Score =  102 bits (253), Expect = 1e-21
 Identities = 74/247 (29%), Positives = 118/247 (47%), Gaps = 31/247 (12%)

Query: 161 TAFHRAAEHGQLD-ALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 219
           T+F RAA  G LD ALD L  +G D N  ++ G   LHLA+  GH+ ++  L+   + LE
Sbjct: 14  TSFLRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 220 EQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
               +G TALH AA     + V+ L+  G+ VNA +QK  + L+ AA     +V + L+ 
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 280 AGGCANVVDHQGASP-----------------------------LHLAVRHNFPALVRLL 310
            G   NV    G +P                             LH+A R++      +L
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           + +D + + +     TPLH+AA +   ++A +LL  G  +N   + G T L +A R  +V
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 371 SLVDMII 377
            +V +++
Sbjct: 253 IMVRLLL 259



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 46/157 (29%), Positives = 76/157 (48%)

Query: 221 QNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHA 280
           + A+  T+   AA   + D     LR G  +N   Q  L+ LH A+  G   +   L+H 
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 281 GGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIA 340
                    +G + LH+A       +VR L+N  ++VNA   +  TPL++AA+    ++ 
Sbjct: 68  EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 341 DMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
             LL  G + N+  + G T LAVA++  H ++V  +I
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  156 bits (395), Expect = 4e-38
 Identities = 105/360 (29%), Positives = 179/360 (49%), Gaps = 12/360 (3%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A ++N +  M+ L+    + +A    G   +H AA  GH   V LLL++ A+ D   
Sbjct: 381 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD--- 437

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
               +T  R   G  AL ++A  G + +++ L+ +GA +   +++  T LH A++ G   
Sbjct: 438 ----VTNIR---GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 490

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           ++  +++ +     D     G T  H +A  GQ+D    L+ +G  H++  K+G T LH+
Sbjct: 491 IVQLLLQHMAHP--DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 548

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  G + V + L+      +     GLT LH AA   +     LLL  G++ +A  +  
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
            + LH AA      ++  L++ G   N+V  QG +PLHLA +     +V LL++  ++++
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
                  T LHLAA+    ++AD+L   G D +   K G T L VA    +V +V+ ++K
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 728



 Score =  153 bits (387), Expect = 3e-37
 Identities = 110/365 (30%), Positives = 181/365 (49%), Gaps = 22/365 (6%)

Query: 19  LHEAARQNNVGRMQELIGR--RVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDE 76
           LH AA   NV     L+ R   V+  ARN  G   LH A+  G+   V+LLL+    +D 
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAAVDFTARN--GITPLHVASKRGNTNMVKLLLDRGGQID- 272

Query: 77  EDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGH 136
                    A+   G+  L  +A  GH +++++L+  GA +   +K+GL+ LH AAQ  H
Sbjct: 273 ---------AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 323

Query: 137 VPVLAFIMED---LEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN 193
           V  +  +++    ++DV LD++     TA H AA  G       L+    + N +   G 
Sbjct: 324 VECVKHLLQHKAPVDDVTLDYL-----TALHVAAHCGHYRVTKLLLDKRANPNARALNGF 378

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           T LH+A  +  + V++ LV  G  ++     GLT +H AA   H + V LLL+ G++ + 
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
              +  + LH AA +G  +V R L+  G   +    +  +PLH+A R     +V+LL+  
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498

Query: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
            +  +A      TPLH++A     D+A +LL AG   +L  K+G T L VA +   + + 
Sbjct: 499 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 558

Query: 374 DMIIK 378
            ++++
Sbjct: 559 KLLLQ 563



 Score =  153 bits (387), Expect = 3e-37
 Identities = 113/363 (31%), Positives = 170/363 (46%), Gaps = 16/363 (4%)

Query: 16  ERQLHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAA 73
           E  LH AAR   V  ++ L+  G  V+ RAR    +  LH A+  G  + V+LLL+H A 
Sbjct: 444 ETALHMAARAGQVEVVRCLLRNGALVDARAREE--QTPLHIASRLGKTEIVQLLLQHMAH 501

Query: 74  VDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQ 133
            D          A    G   L +SA  G + +  +L+ +GA     +K G T LH AA+
Sbjct: 502 PD----------AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAK 551

Query: 134 KGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN 193
            G + V   +++     A D   K G T  H AA +        L+  G   +   K G 
Sbjct: 552 YGSLDVAKLLLQ--RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 609

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           T LH+AA +  M +   L++ G +      +G+T LH A+   H D V LLL  G+ ++ 
Sbjct: 610 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 669

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
            T+  L+ LH AA     +V+ +L   G   +     G +PL +A  +    +V  L+  
Sbjct: 670 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729

Query: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
            ++VNA      TPLH AA+     I ++LL  G   N     G TALA+A R  ++S+V
Sbjct: 730 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789

Query: 374 DMI 376
           D +
Sbjct: 790 DTL 792



 Score =  146 bits (368), Expect = 5e-35
 Identities = 118/428 (27%), Positives = 197/428 (46%), Gaps = 78/428 (18%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA++ +VG +QEL+GR  +  +    G  ALH A+ AG  + V++L++         
Sbjct: 47  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE-------- 98

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L ++A   H+ +++ L+ +GA     ++DG T L  A Q+GH  
Sbjct: 99  --GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQ 156

Query: 139 VLAFIME-------------------DLEDVAL----DH------------VDKLGRTAF 163
            +A ++E                   D +  AL    DH              + G T  
Sbjct: 157 AVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPL 216

Query: 164 HRAAEHGQLD----------ALDF-----------------------LVGSGCDHNVKDK 190
           H AA +G ++          A+DF                       L+  G   + K +
Sbjct: 217 HIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTR 276

Query: 191 EGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGST 250
           +G T LH AA  GH  V++ L++ G  L  +   GL+ LH AA G H +CV+ LL+  + 
Sbjct: 277 DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 336

Query: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
           V+ +T   L+ LH AA  G   V+++L+      N     G +PLH+A + N   ++ LL
Sbjct: 337 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 396

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           +   + + A+     TP+H+AA     +I  +LL  G   ++ + +G+TAL +A R+  V
Sbjct: 397 VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 456

Query: 371 SLVDMIIK 378
            +V  +++
Sbjct: 457 EVVRCLLR 464



 Score =  134 bits (338), Expect = 2e-31
 Identities = 102/369 (27%), Positives = 181/369 (49%), Gaps = 20/369 (5%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHV--------GRVALHWAAGAGHEQAVRLLLEH 70
           LH AAR+++      L+    N   ++ +        G   LH AA  G+     LLL  
Sbjct: 175 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 234

Query: 71  EAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHC 130
            AAVD          AR   G+  L +++  G+  ++++L++ G +I  +++DGLT LHC
Sbjct: 235 GAAVD--------FTARN--GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 284

Query: 131 AAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDK 190
           AA+ GH  V+  ++E      L    K G +  H AA+   ++ +  L+      +    
Sbjct: 285 AARSGHDQVVELLLE--RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 342

Query: 191 EGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGST 250
           +  TALH+AA  GH  V + L+D   +   +   G T LH A   +    ++LL++ G++
Sbjct: 343 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 402

Query: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
           + A+T+  L+ +H AA  G  ++  +L+  G   +V + +G + LH+A R     +VR L
Sbjct: 403 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           + + + V+A    +QTPLH+A+     +I  +LL      +     G T L ++ R   V
Sbjct: 463 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 522

Query: 371 SLVDMIIKA 379
            +  ++++A
Sbjct: 523 DVASVLLEA 531



 Score =  115 bits (288), Expect = 1e-25
 Identities = 83/322 (25%), Positives = 146/322 (45%), Gaps = 39/322 (12%)

Query: 94  ALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALD 153
           + L +A  G+L  +   +  G  I+  +++GL  LH AA++GHV ++  ++      ++D
Sbjct: 13  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG--RGSSVD 70

Query: 154 HVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD 213
              K G TA H A+  GQ + +  LV  G + N + + G T L++AA   H+ V++ L++
Sbjct: 71  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130

Query: 214 IGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL---------------------------- 245
            G +      +G T L  A    H   V +LL                            
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 190

Query: 246 ---------RAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLH 296
                    ++   VN  T+   + LH AA  G+ +V+ +L++ G   +     G +PLH
Sbjct: 191 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 250

Query: 297 LAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQ 356
           +A +     +V+LL++    ++A      TPLH AA      + ++LL  G  L  R K 
Sbjct: 251 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310

Query: 357 GKTALAVAVRSNHVSLVDMIIK 378
           G + L +A + +HV  V  +++
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQ 332



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 56/212 (26%), Positives = 101/212 (47%), Gaps = 12/212 (5%)

Query: 187 VKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLR 246
           ++  + N +   AA  G++  +   +  G+D+   N  GL ALH AA   H   VQ LL 
Sbjct: 5   LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64

Query: 247 AGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPAL 306
            GS+V++ T+K  + LH A+L+G  +V +VL+  G   N     G +PL++A + N   +
Sbjct: 65  RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124

Query: 307 VRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVR 366
           V+ L+ + ++ +       TPL +A +        +LL    + + + K    AL +A R
Sbjct: 125 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAAR 180

Query: 367 SNHVSLVDMIIKADRFYRWEKDHPSDPSGKSL 398
            +      +++        + DH +D   K +
Sbjct: 181 KDDTKSAALLL--------QNDHNADVQSKMM 204



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 10/132 (7%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA+++ V     L     +  A   +G   L  A   G+ + V  LL+         
Sbjct: 678 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-------- 729

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L  +A  GH  I+ +L+  GAK +  + +G T L  A + G++ 
Sbjct: 730 --GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYIS 787

Query: 139 VLAFIMEDLEDV 150
           V+  +    E+V
Sbjct: 788 VVDTLKVVTEEV 799


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  156 bits (395), Expect = 4e-38
 Identities = 105/360 (29%), Positives = 179/360 (49%), Gaps = 12/360 (3%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A ++N +  M+ L+    + +A    G   +H AA  GH   V LLL++ A+ D   
Sbjct: 402 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD--- 458

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
               +T  R   G  AL ++A  G + +++ L+ +GA +   +++  T LH A++ G   
Sbjct: 459 ----VTNIR---GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 511

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           ++  +++ +     D     G T  H +A  GQ+D    L+ +G  H++  K+G T LH+
Sbjct: 512 IVQLLLQHMAHP--DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  G + V + L+      +     GLT LH AA   +     LLL  G++ +A  +  
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
            + LH AA      ++  L++ G   N+V  QG +PLHLA +     +V LL++  ++++
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
                  T LHLAA+    ++AD+L   G D +   K G T L VA    +V +V+ ++K
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749



 Score =  153 bits (387), Expect = 3e-37
 Identities = 110/365 (30%), Positives = 181/365 (49%), Gaps = 22/365 (6%)

Query: 19  LHEAARQNNVGRMQELIGR--RVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDE 76
           LH AA   NV     L+ R   V+  ARN  G   LH A+  G+   V+LLL+    +D 
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARN--GITPLHVASKRGNTNMVKLLLDRGGQID- 293

Query: 77  EDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGH 136
                    A+   G+  L  +A  GH +++++L+  GA +   +K+GL+ LH AAQ  H
Sbjct: 294 ---------AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 344

Query: 137 VPVLAFIMED---LEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN 193
           V  +  +++    ++DV LD++     TA H AA  G       L+    + N +   G 
Sbjct: 345 VECVKHLLQHKAPVDDVTLDYL-----TALHVAAHCGHYRVTKLLLDKRANPNARALNGF 399

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           T LH+A  +  + V++ LV  G  ++     GLT +H AA   H + V LLL+ G++ + 
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
              +  + LH AA +G  +V R L+  G   +    +  +PLH+A R     +V+LL+  
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519

Query: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
            +  +A      TPLH++A     D+A +LL AG   +L  K+G T L VA +   + + 
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579

Query: 374 DMIIK 378
            ++++
Sbjct: 580 KLLLQ 584



 Score =  153 bits (387), Expect = 3e-37
 Identities = 113/363 (31%), Positives = 170/363 (46%), Gaps = 16/363 (4%)

Query: 16  ERQLHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAA 73
           E  LH AAR   V  ++ L+  G  V+ RAR    +  LH A+  G  + V+LLL+H A 
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREE--QTPLHIASRLGKTEIVQLLLQHMAH 522

Query: 74  VDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQ 133
            D          A    G   L +SA  G + +  +L+ +GA     +K G T LH AA+
Sbjct: 523 PD----------AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAK 572

Query: 134 KGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN 193
            G + V   +++     A D   K G T  H AA +        L+  G   +   K G 
Sbjct: 573 YGSLDVAKLLLQ--RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 630

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           T LH+AA +  M +   L++ G +      +G+T LH A+   H D V LLL  G+ ++ 
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
            T+  L+ LH AA     +V+ +L   G   +     G +PL +A  +    +V  L+  
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750

Query: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
            ++VNA      TPLH AA+     I ++LL  G   N     G TALA+A R  ++S+V
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810

Query: 374 DMI 376
           D +
Sbjct: 811 DTL 813



 Score =  146 bits (368), Expect = 5e-35
 Identities = 118/428 (27%), Positives = 197/428 (46%), Gaps = 78/428 (18%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA++ +VG +QEL+GR  +  +    G  ALH A+ AG  + V++L++         
Sbjct: 68  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE-------- 119

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L ++A   H+ +++ L+ +GA     ++DG T L  A Q+GH  
Sbjct: 120 --GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQ 177

Query: 139 VLAFIME-------------------DLEDVAL----DH------------VDKLGRTAF 163
            +A ++E                   D +  AL    DH              + G T  
Sbjct: 178 AVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPL 237

Query: 164 HRAAEHGQLD----------ALDF-----------------------LVGSGCDHNVKDK 190
           H AA +G ++          A+DF                       L+  G   + K +
Sbjct: 238 HIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTR 297

Query: 191 EGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGST 250
           +G T LH AA  GH  V++ L++ G  L  +   GL+ LH AA G H +CV+ LL+  + 
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357

Query: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
           V+ +T   L+ LH AA  G   V+++L+      N     G +PLH+A + N   ++ LL
Sbjct: 358 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 417

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           +   + + A+     TP+H+AA     +I  +LL  G   ++ + +G+TAL +A R+  V
Sbjct: 418 VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 477

Query: 371 SLVDMIIK 378
            +V  +++
Sbjct: 478 EVVRCLLR 485



 Score =  134 bits (338), Expect = 2e-31
 Identities = 102/369 (27%), Positives = 181/369 (49%), Gaps = 20/369 (5%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHV--------GRVALHWAAGAGHEQAVRLLLEH 70
           LH AAR+++      L+    N   ++ +        G   LH AA  G+     LLL  
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255

Query: 71  EAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHC 130
            AAVD          AR   G+  L +++  G+  ++++L++ G +I  +++DGLT LHC
Sbjct: 256 GAAVD--------FTARN--GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305

Query: 131 AAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDK 190
           AA+ GH  V+  ++E      L    K G +  H AA+   ++ +  L+      +    
Sbjct: 306 AARSGHDQVVELLLE--RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 363

Query: 191 EGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGST 250
           +  TALH+AA  GH  V + L+D   +   +   G T LH A   +    ++LL++ G++
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423

Query: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
           + A+T+  L+ +H AA  G  ++  +L+  G   +V + +G + LH+A R     +VR L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           + + + V+A    +QTPLH+A+     +I  +LL      +     G T L ++ R   V
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543

Query: 371 SLVDMIIKA 379
            +  ++++A
Sbjct: 544 DVASVLLEA 552



 Score =  115 bits (288), Expect = 1e-25
 Identities = 83/322 (25%), Positives = 146/322 (45%), Gaps = 39/322 (12%)

Query: 94  ALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALD 153
           + L +A  G+L  +   +  G  I+  +++GL  LH AA++GHV ++  ++      ++D
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG--RGSSVD 91

Query: 154 HVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD 213
              K G TA H A+  GQ + +  LV  G + N + + G T L++AA   H+ V++ L++
Sbjct: 92  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 214 IGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL---------------------------- 245
            G +      +G T L  A    H   V +LL                            
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 211

Query: 246 ---------RAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLH 296
                    ++   VN  T+   + LH AA  G+ +V+ +L++ G   +     G +PLH
Sbjct: 212 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 271

Query: 297 LAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQ 356
           +A +     +V+LL++    ++A      TPLH AA      + ++LL  G  L  R K 
Sbjct: 272 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331

Query: 357 GKTALAVAVRSNHVSLVDMIIK 378
           G + L +A + +HV  V  +++
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQ 353



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 57/211 (27%), Positives = 100/211 (47%), Gaps = 12/211 (5%)

Query: 188 KDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 247
           K  + N +   AA  G++  +   +  G+D+   N  GL ALH AA   H   VQ LL  
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 248 GSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALV 307
           GS+V++ T+K  + LH A+L+G  +V +VL+  G   N     G +PL++A + N   +V
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 308 RLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRS 367
           + L+ + ++ +       TPL +A +        +LL    + + + K    AL +A R 
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARK 202

Query: 368 NHVSLVDMIIKADRFYRWEKDHPSDPSGKSL 398
           +      +++        + DH +D   K +
Sbjct: 203 DDTKSAALLL--------QNDHNADVQSKMM 225



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 10/132 (7%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA+++ V     L     +  A   +G   L  A   G+ + V  LL+         
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-------- 750

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L  +A  GH  I+ +L+  GAK +  + +G T L  A + G++ 
Sbjct: 751 --GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYIS 808

Query: 139 VLAFIMEDLEDV 150
           V+  +    E+V
Sbjct: 809 VVDTLKVVTEEV 820


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  156 bits (395), Expect = 4e-38
 Identities = 105/360 (29%), Positives = 179/360 (49%), Gaps = 12/360 (3%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A ++N +  M+ L+    + +A    G   +H AA  GH   V LLL++ A+ D   
Sbjct: 402 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD--- 458

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
               +T  R   G  AL ++A  G + +++ L+ +GA +   +++  T LH A++ G   
Sbjct: 459 ----VTNIR---GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 511

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           ++  +++ +     D     G T  H +A  GQ+D    L+ +G  H++  K+G T LH+
Sbjct: 512 IVQLLLQHMAHP--DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  G + V + L+      +     GLT LH AA   +     LLL  G++ +A  +  
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
            + LH AA      ++  L++ G   N+V  QG +PLHLA +     +V LL++  ++++
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
                  T LHLAA+    ++AD+L   G D +   K G T L VA    +V +V+ ++K
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749



 Score =  153 bits (387), Expect = 3e-37
 Identities = 110/365 (30%), Positives = 181/365 (49%), Gaps = 22/365 (6%)

Query: 19  LHEAARQNNVGRMQELIGR--RVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDE 76
           LH AA   NV     L+ R   V+  ARN  G   LH A+  G+   V+LLL+    +D 
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARN--GITPLHVASKRGNTNMVKLLLDRGGQID- 293

Query: 77  EDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGH 136
                    A+   G+  L  +A  GH +++++L+  GA +   +K+GL+ LH AAQ  H
Sbjct: 294 ---------AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 344

Query: 137 VPVLAFIMED---LEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN 193
           V  +  +++    ++DV LD++     TA H AA  G       L+    + N +   G 
Sbjct: 345 VECVKHLLQHKAPVDDVTLDYL-----TALHVAAHCGHYRVTKLLLDKRANPNARALNGF 399

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           T LH+A  +  + V++ LV  G  ++     GLT +H AA   H + V LLL+ G++ + 
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
              +  + LH AA +G  +V R L+  G   +    +  +PLH+A R     +V+LL+  
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519

Query: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
            +  +A      TPLH++A     D+A +LL AG   +L  K+G T L VA +   + + 
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579

Query: 374 DMIIK 378
            ++++
Sbjct: 580 KLLLQ 584



 Score =  153 bits (387), Expect = 3e-37
 Identities = 113/363 (31%), Positives = 170/363 (46%), Gaps = 16/363 (4%)

Query: 16  ERQLHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAA 73
           E  LH AAR   V  ++ L+  G  V+ RAR    +  LH A+  G  + V+LLL+H A 
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREE--QTPLHIASRLGKTEIVQLLLQHMAH 522

Query: 74  VDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQ 133
            D          A    G   L +SA  G + +  +L+ +GA     +K G T LH AA+
Sbjct: 523 PD----------AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAK 572

Query: 134 KGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN 193
            G + V   +++     A D   K G T  H AA +        L+  G   +   K G 
Sbjct: 573 YGSLDVAKLLLQ--RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 630

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           T LH+AA +  M +   L++ G +      +G+T LH A+   H D V LLL  G+ ++ 
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
            T+  L+ LH AA     +V+ +L   G   +     G +PL +A  +    +V  L+  
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750

Query: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
            ++VNA      TPLH AA+     I ++LL  G   N     G TALA+A R  ++S+V
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810

Query: 374 DMI 376
           D +
Sbjct: 811 DTL 813



 Score =  146 bits (368), Expect = 5e-35
 Identities = 118/428 (27%), Positives = 197/428 (46%), Gaps = 78/428 (18%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA++ +VG +QEL+GR  +  +    G  ALH A+ AG  + V++L++         
Sbjct: 68  LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE-------- 119

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L ++A   H+ +++ L+ +GA     ++DG T L  A Q+GH  
Sbjct: 120 --GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQ 177

Query: 139 VLAFIME-------------------DLEDVAL----DH------------VDKLGRTAF 163
            +A ++E                   D +  AL    DH              + G T  
Sbjct: 178 AVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPL 237

Query: 164 HRAAEHGQLD----------ALDF-----------------------LVGSGCDHNVKDK 190
           H AA +G ++          A+DF                       L+  G   + K +
Sbjct: 238 HIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTR 297

Query: 191 EGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGST 250
           +G T LH AA  GH  V++ L++ G  L  +   GL+ LH AA G H +CV+ LL+  + 
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357

Query: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
           V+ +T   L+ LH AA  G   V+++L+      N     G +PLH+A + N   ++ LL
Sbjct: 358 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 417

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           +   + + A+     TP+H+AA     +I  +LL  G   ++ + +G+TAL +A R+  V
Sbjct: 418 VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 477

Query: 371 SLVDMIIK 378
            +V  +++
Sbjct: 478 EVVRCLLR 485



 Score =  134 bits (338), Expect = 2e-31
 Identities = 102/369 (27%), Positives = 181/369 (49%), Gaps = 20/369 (5%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHV--------GRVALHWAAGAGHEQAVRLLLEH 70
           LH AAR+++      L+    N   ++ +        G   LH AA  G+     LLL  
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255

Query: 71  EAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHC 130
            AAVD          AR   G+  L +++  G+  ++++L++ G +I  +++DGLT LHC
Sbjct: 256 GAAVD--------FTARN--GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305

Query: 131 AAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDK 190
           AA+ GH  V+  ++E      L    K G +  H AA+   ++ +  L+      +    
Sbjct: 306 AARSGHDQVVELLLE--RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL 363

Query: 191 EGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGST 250
           +  TALH+AA  GH  V + L+D   +   +   G T LH A   +    ++LL++ G++
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS 423

Query: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
           + A+T+  L+ +H AA  G  ++  +L+  G   +V + +G + LH+A R     +VR L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           + + + V+A    +QTPLH+A+     +I  +LL      +     G T L ++ R   V
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543

Query: 371 SLVDMIIKA 379
            +  ++++A
Sbjct: 544 DVASVLLEA 552



 Score =  115 bits (288), Expect = 1e-25
 Identities = 83/322 (25%), Positives = 146/322 (45%), Gaps = 39/322 (12%)

Query: 94  ALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALD 153
           + L +A  G+L  +   +  G  I+  +++GL  LH AA++GHV ++  ++      ++D
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG--RGSSVD 91

Query: 154 HVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD 213
              K G TA H A+  GQ + +  LV  G + N + + G T L++AA   H+ V++ L++
Sbjct: 92  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 214 IGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL---------------------------- 245
            G +      +G T L  A    H   V +LL                            
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 211

Query: 246 ---------RAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLH 296
                    ++   VN  T+   + LH AA  G+ +V+ +L++ G   +     G +PLH
Sbjct: 212 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 271

Query: 297 LAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQ 356
           +A +     +V+LL++    ++A      TPLH AA      + ++LL  G  L  R K 
Sbjct: 272 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331

Query: 357 GKTALAVAVRSNHVSLVDMIIK 378
           G + L +A + +HV  V  +++
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQ 353



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 57/211 (27%), Positives = 100/211 (47%), Gaps = 12/211 (5%)

Query: 188 KDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 247
           K  + N +   AA  G++  +   +  G+D+   N  GL ALH AA   H   VQ LL  
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 248 GSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALV 307
           GS+V++ T+K  + LH A+L+G  +V +VL+  G   N     G +PL++A + N   +V
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 308 RLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRS 367
           + L+ + ++ +       TPL +A +        +LL    + + + K    AL +A R 
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARK 202

Query: 368 NHVSLVDMIIKADRFYRWEKDHPSDPSGKSL 398
           +      +++        + DH +D   K +
Sbjct: 203 DDTKSAALLL--------QNDHNADVQSKMM 225



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 10/132 (7%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA+++ V     L     +  A   +G   L  A   G+ + V  LL+         
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-------- 750

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA   A+   G   L  +A  GH  I+ +L+  GAK +  + +G T L  A + G++ 
Sbjct: 751 --GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYIS 808

Query: 139 VLAFIMEDLEDV 150
           V+  +    E+V
Sbjct: 809 VVDTLKVVTEEV 820


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  156 bits (394), Expect = 5e-38
 Identities = 111/375 (29%), Positives = 174/375 (46%), Gaps = 40/375 (10%)

Query: 36   GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNAL 95
            G  VN +A N  GR AL  AA  GH + V  LL+H A V+ ED  G     R    + AL
Sbjct: 667  GAEVN-KADNE-GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDG-----RTALSVAAL 719

Query: 96   LLSAWFGHLRILQILVNSGAKI-HCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDV---- 150
             + A  GH  ++ +L++ GA++ HC+ KDG+T L  AA +GHV V+  ++E   DV    
Sbjct: 720  CVPASKGHASVVSLLIDRGAEVDHCD-KDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTD 778

Query: 151  ---------------------------ALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGC 183
                                       A+D +D  GRT    A+  G ++ +  L+  G 
Sbjct: 779  NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 838

Query: 184  DHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQL 243
            D N +D  G T LH+AA  GH  + + L++ G    E + +G      A+   H DCVQ+
Sbjct: 839  DENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 898

Query: 244  LLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNF 303
            LL   S ++       + L  AAL G  D+  +L   G   N  D  G   L++    N 
Sbjct: 899  LLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958

Query: 304  PALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAV 363
              +    + + ++V A D   +T LH++      ++  +L+    D+N  D + ++AL  
Sbjct: 959  LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018

Query: 364  AVRSNHVSLVDMIIK 378
            A    HV +V ++I+
Sbjct: 1019 AAWQGHVKVVQLLIE 1033



 Score =  143 bits (361), Expect = 3e-34
 Identities = 103/365 (28%), Positives = 168/365 (46%), Gaps = 17/365 (4%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           L  AA   ++  +  L+ R  +    +  G   L  AA  GH + V  L+   A ++  D
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTD 608

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             G            AL  +AW GH  ++  L+ +G K+ C   D  T L  AA  GH  
Sbjct: 609 QDG----------WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHED 658

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           ++  +++   +V  +  D  GRTA   AA  G  + ++ L+  G + N +D +G TAL +
Sbjct: 659 IVLNLLQHGAEV--NKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSV 716

Query: 199 A-----AGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           A     A +GH +V+  L+D G +++  + +G+T L  AA   H D V LLL  G+ V+ 
Sbjct: 717 AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDH 776

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
                 + L  AA  G   V   L+  G   + +D +G + L +A       +VR L++ 
Sbjct: 777 TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836

Query: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
             D N  D+   TPLH+AA    + I + L+  G   N  D  G+    +A +  H   V
Sbjct: 837 GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCV 896

Query: 374 DMIIK 378
            ++++
Sbjct: 897 QILLE 901



 Score =  124 bits (312), Expect = 2e-28
 Identities = 83/278 (29%), Positives = 139/278 (50%), Gaps = 9/278 (3%)

Query: 106 ILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHR 165
           +LQ+LV +GA ++ E      ++  A ++     +  ++++    +++  D  GRT    
Sbjct: 496 VLQLLVKAGAHVNSEDDRTSCIVRQALEREDS--IRTLLDN--GASVNQCDSNGRTLLAN 551

Query: 166 AAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEG 225
           AA  G LD ++ LV  G D  ++D  G+T L LAA +GH  V+  L+  G ++   + +G
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611

Query: 226 LTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCAN 285
            TAL SAA G H + V  LL AG  V+     + + L  AA  G ED+   L+  G   N
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671

Query: 286 VVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLA-----AEHAWQDIA 340
             D++G + L  A       +V  L++  ++VN  D   +T L +A     A      + 
Sbjct: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731

Query: 341 DMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
            +L+  G +++  DK G T L VA    HV +VD++++
Sbjct: 732 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769



 Score =  115 bits (288), Expect = 1e-25
 Identities = 82/278 (29%), Positives = 141/278 (50%), Gaps = 14/278 (5%)

Query: 19   LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
            LH AA + +    + LI +   T   ++ GR+    A+  GH   V++LLE+++ +D+  
Sbjct: 851  LHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQ-- 908

Query: 79   AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                    R   G NAL ++A  GH  I+++L + GA ++C+  DG   L+  A +  + 
Sbjct: 909  --------RGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT 960

Query: 139  VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
            +  + +E+  +V  +  D  GRTA H +   G ++ +  L+    D N  D E  +AL  
Sbjct: 961  MAEYFLENGANV--EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018

Query: 199  AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
            AA +GH+ V+Q L++ G  ++    +G TAL  AA   H D VQ+LL  G+  N   Q  
Sbjct: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFG 1078

Query: 259  LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLH 296
             + +  AA +G   + ++L   G  A+ ++    SP+H
Sbjct: 1079 RTAMRVAAKNGHSQIIKLLEKYG--ASSLNGCSPSPVH 1114



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 75/264 (28%), Positives = 120/264 (45%), Gaps = 25/264 (9%)

Query: 8    ETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLL 67
            + DG +P       A+++ +   +Q L+  + N   R + GR AL  AA  GH   V LL
Sbjct: 877  DNDGRIPFIL----ASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 932

Query: 68   LEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTL 127
              H A V+ +DA G  T          L + A    L + +  + +GA +     +G T 
Sbjct: 933  FSHGADVNCKDADGRPT----------LYILALENQLTMAEYFLENGANVEASDAEGRTA 982

Query: 128  LHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNV 187
            LH +  +GH+ ++  ++    DV  +  D   R+A   AA  G +  +  L+  G   + 
Sbjct: 983  LHVSCWQGHMEMVQVLIAYHADV--NAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH 1040

Query: 188  KDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 247
               +G TAL +AA  GH+ V+Q L++ G D    +  G TA+  AA   H   ++LL + 
Sbjct: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY 1100

Query: 248  G---------STVNALTQKNLSCL 262
            G         S V+ + QK L  L
Sbjct: 1101 GASSLNGCSPSPVHTMEQKPLQSL 1124



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 44/141 (31%), Positives = 68/141 (48%), Gaps = 2/141 (1%)

Query: 239 DCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLA 298
           + +QLL++AG+ VN+   +  SC+   AL   ED  R L+  G   N  D  G + L  A
Sbjct: 495 EVLQLLVKAGAHVNSEDDRT-SCIVRQALE-REDSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 299 VRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGK 358
                  +V LL++  +D+   D    TPL LAA      + + L+  G ++N  D+ G 
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612

Query: 359 TALAVAVRSNHVSLVDMIIKA 379
           TAL  A    H  +V  ++ A
Sbjct: 613 TALRSAAWGGHTEVVSALLYA 633


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  154 bits (388), Expect = 2e-37
 Identities = 121/416 (29%), Positives = 192/416 (46%), Gaps = 46/416 (11%)

Query: 8   ETDGLLPLERQ--LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVR 65
           E   +L  ER+  LH AA   +V  +Q L+    N  A++ +    LH AA + +E+ + 
Sbjct: 32  ENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLG 91

Query: 66  LLLEHEAAVDEEDA-------VGALTEARLC----------------FGMNALLLSAWFG 102
           LLL H A V+  D        V A   A  C                 G +AL  +   G
Sbjct: 92  LLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSG 151

Query: 103 HLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTA 162
           HL  + +L+N GA ++   K     LH AA  GH+ VL  ++    D+     D+ G   
Sbjct: 152 HLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCK--DRKGYGL 209

Query: 163 FHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQN 222
            H AA  GQ++ + +L+  G + +  +  GNTALH+A   G  AV   LV+ G ++ + N
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269

Query: 223 AEGLTALHSAAGGSHPD-CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAG 281
            +G T LH AA  ++   C++LL+  G+ VN  +++  S LH AA+ G    S++LI  G
Sbjct: 270 DKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNG 329

Query: 282 GCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIA- 340
              +  D  G +PLH+A R+    L+  L+ + +D          PLHLA    + D   
Sbjct: 330 SEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCR 389

Query: 341 -----------------DMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
                            + +L AG D+N  D  G+T L  A    +V  +++++ +
Sbjct: 390 KLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS 445



 Score =  146 bits (368), Expect = 5e-35
 Identities = 110/370 (29%), Positives = 177/370 (47%), Gaps = 15/370 (4%)

Query: 11  GLLPLERQ--LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLL 68
           G+L +  Q  L +A    +V  ++ L+ ++ N    +   R  LH AA  G    ++LLL
Sbjct: 2   GILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLL 61

Query: 69  EHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLL 128
              A V+ +D +      R     N           ++L +L+   A ++   K   T L
Sbjct: 62  MSGANVNAKDTLWLTPLHRAAASRNE----------KVLGLLLAHSADVNARDKLWQTPL 111

Query: 129 HCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVK 188
           H AA          +   L   +L+  D+ GR+A H A   G L+ ++ L+  G   NV 
Sbjct: 112 HVAAANRATKCAEALAPLLS--SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVC 169

Query: 189 DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG 248
           DK+    LH AA  GH+ VL+ LV  G DL  ++ +G   LH+AA     + V+ LLR G
Sbjct: 170 DKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMG 229

Query: 249 STVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHL-AVRHNFPALV 307
           + ++       + LH A   G + V+  L++AG   N  + +G +PLH+ AV  N    +
Sbjct: 230 AEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCL 289

Query: 308 RLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRS 367
            LL+N+ +DVN      ++PLH+AA H     + +L+  G +++  DK G T L VA R 
Sbjct: 290 ELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARY 349

Query: 368 NHVSLVDMII 377
            H  L+  ++
Sbjct: 350 GHELLISTLM 359



 Score =  133 bits (335), Expect = 3e-31
 Identities = 113/380 (29%), Positives = 169/380 (44%), Gaps = 31/380 (8%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA        + L     +    +  GR ALH A  +GH + V LLL   A+++  D
Sbjct: 111 LHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCD 170

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                           L  +A+ GHL +L++LV  GA + C+ + G  LLH AA  G + 
Sbjct: 171 KKER----------QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIE 220

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           V+ +++       +D  +  G TA H A   GQ      LV +G + N  + +G T LH+
Sbjct: 221 VVKYLLR--MGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHV 278

Query: 199 AAGRGHMAV-LQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK 257
           AA   + A+ L+ LV+ G D+  Q+ EG + LH AA        Q+L++ GS ++   + 
Sbjct: 279 AAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKF 338

Query: 258 NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDS-- 315
             + LH AA  G E +   L+  G            PLHLAV   F    R L++S    
Sbjct: 339 GNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLY 398

Query: 316 ----------------DVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKT 359
                           D+N  DN  +T LH AA     +  ++LL +G DL  RDK G+T
Sbjct: 399 SIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRT 458

Query: 360 ALAVAVRSNHVSLVDMIIKA 379
            L  A  +        ++ A
Sbjct: 459 PLHYAAANGSYQCAVTLVTA 478



 Score =  130 bits (327), Expect = 3e-30
 Identities = 111/369 (30%), Positives = 168/369 (45%), Gaps = 22/369 (5%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA   +   ++ L    VN   R+H GR AL  A   G  + V +L  H A+   ++
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCES---KDGLTLLHCAAQKG 135
                T          L  +A  GH   L +L++SG +          G T L  A   G
Sbjct: 649 RKRKWTP---------LHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNG 699

Query: 136 HVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTA 195
           HV  +  ++E  +    D  D  GRTA HR A  G  D L  L+        +D +G T 
Sbjct: 700 HVDCVHLLLE--KGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTP 757

Query: 196 LHLAAGRGHMAVLQRLVDIGLDLEEQNA----EGLTALHSAAGGSHPDCVQLLLRAGSTV 251
           +HLA+  GH AVL+ L+   L  +  +A     G + +H A+   H DC++LLL   S  
Sbjct: 758 IHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPF 816

Query: 252 NALTQKNLSCLHYAALSGSEDVSRVLIHAGGC--ANVVDHQGASPLHLAVRHNFPALVRL 309
           + L     + LH A ++  +  + +L+ A G    N  D +G +PLH A   +  + +R+
Sbjct: 817 SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRM 876

Query: 310 LINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAG-VDLNLRDKQGKTALAVAVRSN 368
           L+   ++VNA D+  +T L  AAE+      + LL  G  DL + D+   TAL +A    
Sbjct: 877 LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKG 936

Query: 369 HVSLVDMII 377
           H     MI+
Sbjct: 937 HEKCALMIL 945



 Score =  119 bits (299), Expect = 5e-27
 Identities = 118/422 (27%), Positives = 173/422 (40%), Gaps = 64/422 (15%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH AA   NV  +  L+    + R R+  GR  LH+AA  G  Q    L+   A V+E D
Sbjct: 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486

Query: 79  AVGALT-----------------------------------EARLCF------------- 90
             G                                      EA  C              
Sbjct: 487 CKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLR 546

Query: 91  ---GMNALLLSAWFGHLRILQILVNSGAKI--HCESKDGLTLLHCAAQKGHVPVLAFIME 145
              G  A+  +A +G+ + L++L+          ES   ++ LH AA  GH   L  + E
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606

Query: 146 DLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN-TALHLAAGRGH 204
            L  V LD  D  GRTA   A E G  + ++ L   G    +K+++   T LH AA  GH
Sbjct: 607 TL--VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGH 664

Query: 205 MAVLQRLVDIG--LDLEE-QNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSC 261
              L  L+D G   D+ +  +A G T L  A    H DCV LLL  GST +A   +  + 
Sbjct: 665 TDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTA 724

Query: 262 LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL----INSDSDV 317
           LH  A++G ED    L+         D +G +P+HLA      A++R L    +++D   
Sbjct: 725 LHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLD 784

Query: 318 NAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
             VD    +P+H A+    +D  + LL+     +  +    T L  AV +N  S  +M++
Sbjct: 785 AGVDYSGYSPMHWASYTGHEDCLE-LLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLL 843

Query: 378 KA 379
            A
Sbjct: 844 GA 845



 Score =  115 bits (288), Expect = 1e-25
 Identities = 126/495 (25%), Positives = 196/495 (39%), Gaps = 119/495 (24%)

Query: 16  ERQ-LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           ERQ LH AA   ++  ++ L+ R  +   ++  G   LH AA +G  + V+ LL   A +
Sbjct: 173 ERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEI 232

Query: 75  DEEDAVGALTEARLCF-GMNALLLSA-------------WFGHLRI----------LQIL 110
           DE +A G       C+ G +A+ +                F  L +          L++L
Sbjct: 233 DEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELL 292

Query: 111 VNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHG 170
           VN+GA ++ +SK+G + LH AA  G       ++++  ++  D  DK G T  H AA +G
Sbjct: 293 VNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI--DCADKFGNTPLHVAARYG 350

Query: 171 ---------------------------------------------QLDAL------DFLV 179
                                                        QL ++      + ++
Sbjct: 351 HELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVL 410

Query: 180 GSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPD 239
            +G D N  D  G T LH AA  G++  L  L+  G DL  ++  G T LH AA      
Sbjct: 411 SAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQ 470

Query: 240 CVQLLLRAGSTVNALTQKNLSCLHYAALS-----------GSEDVS-------------- 274
           C   L+ AG+ VN    K  S LHYAA S            S D                
Sbjct: 471 CAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAF 530

Query: 275 ---RVLIHAGGCANVVDHQGASPLHLAV----RHNFPALVRLLINSDSDVNAVDNRQQTP 327
                L+  G   ++ D QG + +H A     R N   L+ +  N   DV +      +P
Sbjct: 531 FCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVES--TIPVSP 588

Query: 328 LHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMI-------IKAD 380
           LHLAA +   +    L    V+L++RD +G+TAL +A        V+++       +  +
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648

Query: 381 RFYRWEKDHPSDPSG 395
           R  +W   H +  SG
Sbjct: 649 RKRKWTPLHAAAASG 663



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 82/310 (26%), Positives = 136/310 (43%), Gaps = 29/310 (9%)

Query: 48   GRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRIL 107
            GR ALH  A  G E  +  LL+H+A V   D  G             + L++  GH  +L
Sbjct: 721  GRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGR----------TPIHLASACGHTAVL 770

Query: 108  QILVNSGAKIHCESKD------GLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRT 161
            + L+   A +  +  D      G + +H A+  GH   L  +   LE     +++    T
Sbjct: 771  RTLLQ--AALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL---LEHSPFSYLEGNPFT 825

Query: 162  AFHRAAEHGQLDALDFLVGS--GCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 219
              H A  + Q    + L+G+      N +D +G T LH AA   +++ L+ L+    ++ 
Sbjct: 826  PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885

Query: 220  EQNAEGLTALHSAAGGSHPDCVQLLLRAGST-VNALTQKNLSCLHYAALSGSEDVSRVLI 278
              +  G TAL +AA       V+ LL  G   +  L +   + LH A   G E  + +++
Sbjct: 886  ATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMIL 945

Query: 279  HAG---GCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHA 335
                  G  N  +     PLH+A R+   ++V+ L++  + V AVD    TP    A + 
Sbjct: 946  AETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN- 1004

Query: 336  WQDIADMLLI 345
             +D+AD L +
Sbjct: 1005 -KDVADCLAL 1013



 Score = 82.8 bits (203), Expect = 7e-16
 Identities = 73/280 (26%), Positives = 112/280 (40%), Gaps = 11/280 (3%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH  A       +  L+        R+  GR  +H A+  GH   +R LL+   + D  D
Sbjct: 725 LHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLD 784

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
           A    +      G + +  +++ GH   L++L+      + E     T LHCA       
Sbjct: 785 AGVDYS------GYSPMHWASYTGHEDCLELLLEHSPFSYLEGNP-FTPLHCAVINNQDS 837

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
               ++  L    ++  D  GRT  H AA    +  L  L+    + N  D  G TAL  
Sbjct: 838 TTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMT 897

Query: 199 AAGRGHMAVLQRLVDIG-LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK 257
           AA  G  A ++ L+  G  DL   +    TALH A    H  C  ++L     +  +   
Sbjct: 898 AAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINAT 957

Query: 258 NLSC---LHYAALSGSEDVSRVLIHAGGCANVVDHQGASP 294
           N +    LH AA +G   V + L+  G     VD +G +P
Sbjct: 958 NSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  150 bits (378), Expect = 4e-36
 Identities = 113/363 (31%), Positives = 174/363 (47%), Gaps = 21/363 (5%)

Query: 15  LERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           L+R L  + R+N V R +EL          N V    LH+    G  + VRLLL HE  V
Sbjct: 337 LKRALQLSDRKNLVPRDEELC------IYENKV--TPLHFLVAQGSVEQVRLLLAHEVDV 388

Query: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
           D + A G             LL++A      +  +L+  GA  +   +DG   LH AAQ 
Sbjct: 389 DCQTASG----------YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQN 438

Query: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNT 194
           G       +++      +D  ++ G T  H AA++   +    LV    D N+ + EG T
Sbjct: 439 GDDGTARLLLD--HGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKT 496

Query: 195 ALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNAL 254
            LH+AA  GH+++++ L   G +L+ Q     T LH A        +Q LL++G+  +AL
Sbjct: 497 PLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDAL 556

Query: 255 TQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSD 314
            Q     LH AA  G   + ++L+  G    +  HQG +PLHLA       ++ LL  S 
Sbjct: 557 DQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESH 616

Query: 315 SDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAV-RSNHVSLV 373
           +++ A+     TPLHLAA H  + +   LL  G D N  ++ G T L +AV RS  +S++
Sbjct: 617 ANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVI 676

Query: 374 DMI 376
           +++
Sbjct: 677 NLL 679



 Score =  143 bits (360), Expect = 4e-34
 Identities = 104/329 (31%), Positives = 157/329 (47%), Gaps = 12/329 (3%)

Query: 48  GRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRIL 107
           G   LH+AA  G +   RLLL+H A VD ++  G             L L+A      + 
Sbjct: 428 GWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG----------WTPLHLAAQNNFENVA 477

Query: 108 QILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAA 167
           ++LV+  A  +    +G T LH AA  GHV ++  +    +   LD   +  RT  H A 
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTS--QGAELDAQQRNLRTPLHLAV 535

Query: 168 EHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLT 227
           E G++ A+  L+ SG   +  D+ G   LH AA RG   + + L+  G  LE    +G T
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWT 595

Query: 228 ALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVV 287
            LH AA   H + + LL  + + + AL   N + LH AA  G E V   L+  G   N  
Sbjct: 596 PLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655

Query: 288 DHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAG 347
           +  G +PLHLAV+ +    V  L+   ++V+A +    TP HLAA      I  +L+ AG
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAG 715

Query: 348 VDLNLRDKQGKTALAVAVRSNHVSLVDMI 376
             L+++D    T L +A+RS    ++  +
Sbjct: 716 AQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  105 bits (262), Expect = 1e-22
 Identities = 57/186 (30%), Positives = 100/186 (53%)

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           T LH    +G +  ++ L+   +D++ Q A G T L  AA    PD   LLL  G+  N 
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
           + +   + LH+AA +G +  +R+L+  G C +  + +G +PLHLA ++NF  + RLL++ 
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483

Query: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
            +D N  +   +TPLH+AA      +  +L   G +L+ + +  +T L +AV    V  +
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543

Query: 374 DMIIKA 379
             ++K+
Sbjct: 544 QHLLKS 549



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 93/314 (29%), Positives = 134/314 (42%), Gaps = 20/314 (6%)

Query: 6   AWETDGLLPLERQLHEAARQN--NVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQA 63
           A E +G  PL    H AA+ N  NV R+  L+ R+ +       G+  LH AA  GH   
Sbjct: 456 AQEREGWTPL----HLAAQNNFENVARL--LVSRQADPNLHEAEGKTPLHVAAYFGHVSL 509

Query: 64  VRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKD 123
           V+LL    A +D +       +  L      L L+   G +R +Q L+ SGA      + 
Sbjct: 510 VKLLTSQGAELDAQ-------QRNL---RTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559

Query: 124 GLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGC 183
           G   LH AA +G   +   ++      +L+     G T  H AA  G L+ +  L  S  
Sbjct: 560 GYGPLHTAAARGKYLICKMLLR--YGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHA 617

Query: 184 DHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQL 243
           +         T LHLAA  G  AV+  L+  G D       G T LH A   S    V  
Sbjct: 618 NMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677

Query: 244 LLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNF 303
           LL   + V+A  +   +  H AAL G+  + +VL+ AG   +V D    +PL LA+R   
Sbjct: 678 LLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRK 737

Query: 304 PALVRLLINSDSDV 317
             ++  L   +  V
Sbjct: 738 QGIMSFLEGKEPSV 751



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 74/261 (28%), Positives = 117/261 (44%), Gaps = 2/261 (0%)

Query: 119 CESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFL 178
           C  ++ +T LH    +G V  +  ++    +V +D     G T    AA+  Q D    L
Sbjct: 357 CIYENKVTPLHFLVAQGSVEQVRLLLA--HEVDVDCQTASGYTPLLIAAQDQQPDLCALL 414

Query: 179 VGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHP 238
           +  G D N  D++G   LH AA  G     + L+D G  ++ Q  EG T LH AA  +  
Sbjct: 415 LAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFE 474

Query: 239 DCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLA 298
           +  +LL+   +  N    +  + LH AA  G   + ++L   G   +       +PLHLA
Sbjct: 475 NVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLA 534

Query: 299 VRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGK 358
           V       ++ L+ S +  +A+D     PLH AA      I  MLL  G  L L   QG 
Sbjct: 535 VERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW 594

Query: 359 TALAVAVRSNHVSLVDMIIKA 379
           T L +A    H+ ++ ++ ++
Sbjct: 595 TPLHLAAYKGHLEIIHLLAES 615


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  147 bits (370), Expect = 3e-35
 Identities = 89/288 (30%), Positives = 146/288 (50%), Gaps = 2/288 (0%)

Query: 91  GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDV 150
           G   LL++A  G+++ILQ+L+  G++I  + K G   ++ AA+ GHV  L F+ E+    
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN--KC 436

Query: 151 ALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQR 210
            LD  DK G  A H AA +G  D    L   G + N++DKE  T LH AA  G+ +V + 
Sbjct: 437 PLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKA 496

Query: 211 LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 270
           L + G ++  +N EG T L +A+   + D V+ L   G+ +NA  +     LH A     
Sbjct: 497 LCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 556

Query: 271 EDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHL 330
            +V + L+  G   +  D  G +PLH+A +     +V  L  ++ +++  +   +TPLHL
Sbjct: 557 MEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHL 616

Query: 331 AAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
           AA +   D+   L + G  +      GKTA  +A    H  +  ++ +
Sbjct: 617 AANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLAR 664



 Score =  119 bits (297), Expect = 9e-27
 Identities = 93/302 (30%), Positives = 143/302 (47%), Gaps = 14/302 (4%)

Query: 74  VDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAK--IHCESKDGLTLLHCA 131
           +DEED+          F M A++ +    ++  LQ L+ S +   ++  +K G   L  A
Sbjct: 337 LDEEDS----------FVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIA 386

Query: 132 AQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE 191
           A  G++ +L  +++      +D  DK G  A + AA HG +D L FL  + C  +VKDK 
Sbjct: 387 AGCGNIQILQLLIK--RGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKS 444

Query: 192 GNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTV 251
           G  ALH+AA  GH  V Q L   G +   Q+ E  T LH AA   +    + L  AG  V
Sbjct: 445 GEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNV 504

Query: 252 NALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLI 311
           N   ++  + L  A+  G  D+   L   G   N  D  G   LHLAVR     +++ L+
Sbjct: 505 NIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL 564

Query: 312 NSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVS 371
           +    V+  D    TPLH+A +     I   L  A  +L++ +K G+T L +A  +  + 
Sbjct: 565 SQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILD 624

Query: 372 LV 373
           +V
Sbjct: 625 VV 626



 Score =  110 bits (276), Expect = 2e-24
 Identities = 74/250 (29%), Positives = 120/250 (48%)

Query: 131 AAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDK 190
           A    +VP L  ++  L +  ++  +K G      AA  G +  L  L+  G   +V+DK
Sbjct: 351 AINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDK 410

Query: 191 EGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGST 250
            G+ A++ AA  GH+  L+ L +    L+ ++  G  ALH AA   H D  QLL   GS 
Sbjct: 411 GGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSN 470

Query: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
            N   ++  + LH AA  G   V++ L  AG   N+ + +G +PL  A    +  +V  L
Sbjct: 471 PNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECL 530

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
               +D+NA D      LHLA      ++   LL  G  ++ +D+ G T L VA +  ++
Sbjct: 531 AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNM 590

Query: 371 SLVDMIIKAD 380
            +V  + +A+
Sbjct: 591 PIVVALCEAN 600



 Score =  109 bits (273), Expect = 5e-24
 Identities = 72/247 (29%), Positives = 116/247 (46%), Gaps = 2/247 (0%)

Query: 149 DVALDHVDKLGRTAFHRAAEHGQLDALDFLVGS--GCDHNVKDKEGNTALHLAAGRGHMA 206
           D  LD  D     A   A     +  L  L+GS    D N  +K G   L +AAG G++ 
Sbjct: 334 DDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQ 393

Query: 207 VLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAA 266
           +LQ L+  G  ++ Q+  G  A++ AA   H D ++ L      ++   +     LH AA
Sbjct: 394 ILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA 453

Query: 267 LSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQT 326
             G  DV+++L   G   N+ D +  +PLH A  H + ++ + L  +  +VN  +   +T
Sbjct: 454 RYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGET 513

Query: 327 PLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWE 386
           PL  A+   + DI + L   G DLN  DK G  AL +AVR   + ++  ++    F  ++
Sbjct: 514 PLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQ 573

Query: 387 KDHPSDP 393
             H + P
Sbjct: 574 DRHGNTP 580



 Score =  108 bits (269), Expect = 2e-23
 Identities = 85/297 (28%), Positives = 135/297 (45%), Gaps = 12/297 (4%)

Query: 22  AARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVG 81
           AA   N+  +Q LI R      ++  G  A++WAA  GH   ++ L E++  +D +D  G
Sbjct: 386 AAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSG 445

Query: 82  ALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLA 141
            +          AL ++A +GH  + Q+L + G+  + + K+  T LHCAA  G+  V  
Sbjct: 446 EM----------ALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAK 495

Query: 142 FIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAG 201
            + E   +V + + +  G T    A+  G  D ++ L   G D N  DK+G+ ALHLA  
Sbjct: 496 ALCEAGCNVNIKNRE--GETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVR 553

Query: 202 RGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSC 261
           R  M V++ L+  G  ++ Q+  G T LH A    +   V  L  A   ++   +   + 
Sbjct: 554 RCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTP 613

Query: 262 LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
           LH AA +G  DV R L   G     +   G +   LA       +  LL     D +
Sbjct: 614 LHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTH 670



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 62/231 (26%), Positives = 101/231 (43%), Gaps = 12/231 (5%)

Query: 16  ERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75
           E  LH AAR  +    Q L     N   ++      LH AA  G+    + L E    V+
Sbjct: 446 EMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVN 505

Query: 76  EEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKG 135
            ++  G             LL ++  G+  I++ L   GA ++   KDG   LH A ++ 
Sbjct: 506 IKNREGE----------TPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRC 555

Query: 136 HVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTA 195
            + V+  ++   +   +D+ D+ G T  H A + G +  +  L  + C+ ++ +K G T 
Sbjct: 556 QMEVIKTLLS--QGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTP 613

Query: 196 LHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLR 246
           LHLAA  G + V++ L  +G  +E    +G TA   A    H     LL R
Sbjct: 614 LHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLAR 664


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  143 bits (360), Expect = 4e-34
 Identities = 107/366 (29%), Positives = 179/366 (48%), Gaps = 24/366 (6%)

Query: 48  GRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRIL 107
           G   LH A  AG E+  + LL + A  +       L+  R   G   L ++       ++
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPN-------LSNRR---GSTPLHMAVERRVRGVV 487

Query: 108 QILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAA 167
           ++L+     ++ + +D  T LH AAQ G       ++E  ++ +++ VD  GRT  H A 
Sbjct: 488 ELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLE--KNASVNEVDFEGRTPMHVAC 545

Query: 168 EHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV-DIGLDLEEQNAEGL 226
           +HGQ + +  L+  G D +++ K+    LH AA +GH+ +++ L    G+ +  Q  +G 
Sbjct: 546 QHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR 605

Query: 227 TALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANV 286
           T LH AA   H    ++L+   S VN  +    + LH AA +G    +R+L+H G     
Sbjct: 606 TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA 665

Query: 287 VDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIA 346
           +   G + LHLA R+   A V+LL+   +DV A     QT LHLAA H   ++ + L+ A
Sbjct: 666 MTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSA 725

Query: 347 GVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSLSFKQDHRQ 406
            V ++L D+QG +AL +A +  H   V+ +++          H +  + +SL F+  H  
Sbjct: 726 DV-IDLFDEQGLSALHLAAQGRHAQTVETLLR----------HGAHINLQSLKFQGGHGP 774

Query: 407 ETQQLR 412
               LR
Sbjct: 775 AATLLR 780



 Score =  131 bits (329), Expect = 2e-30
 Identities = 93/300 (31%), Positives = 143/300 (47%), Gaps = 12/300 (4%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           LH A  +   G ++ L+ R+++  A++     ALH+AA  G E + RLLLE  A+V+E D
Sbjct: 475 LHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
                       G   + ++   G   I++IL+  G  +  + KD    LH AA +GH+P
Sbjct: 535 FE----------GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLP 584

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
           ++  + +    V+++     GRT  H AA+ G       L+    D NV      T LH+
Sbjct: 585 IVKLLAKQ-PGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHV 643

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           AA  GH +  + L+  G   E   ++G TALH AA   H   V+LL+   + V A    N
Sbjct: 644 AAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLN 703

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
            + LH AA  G  +V   L+ A    ++ D QG S LHLA +      V  L+   + +N
Sbjct: 704 QTALHLAAAHGHSEVVEELVSA-DVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  102 bits (254), Expect = 9e-22
 Identities = 81/301 (26%), Positives = 132/301 (43%), Gaps = 44/301 (14%)

Query: 149 DVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVL 208
           D+ALD     G +  H A E GQ +   +L+ +  + N+ ++ G+T LH+A  R    V+
Sbjct: 432 DLALDS----GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVV 487

Query: 209 QRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALS 268
           + L+   + +  ++ +  TALH AA        +LLL   ++VN +  +  + +H A   
Sbjct: 488 ELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQH 547

Query: 269 GSEDVSRVLI----------------------------------HAGGCANVVDHQGASP 294
           G E++ R+L+                                    G   N     G +P
Sbjct: 548 GQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTP 607

Query: 295 LHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRD 354
           LHLA +     + R+LI+  SDVN      QTPLH+AAE      A +LL  G       
Sbjct: 608 LHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMT 667

Query: 355 KQGKTALAVAVRSNHVSLVDMII--KADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLR 412
             G TAL +A R+ H++ V +++  KAD   R     P + +   L+    H +  ++L 
Sbjct: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLAR----GPLNQTALHLAAAHGHSEVVEELV 723

Query: 413 S 413
           S
Sbjct: 724 S 724



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 37/128 (28%), Positives = 66/128 (51%)

Query: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
           V+       S LH A  +G E+ ++ L+      N+ + +G++PLH+AV      +V LL
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490

Query: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
           +     VNA D  Q T LH AA++  +    +LL     +N  D +G+T + VA +    
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550

Query: 371 SLVDMIIK 378
           ++V ++++
Sbjct: 551 NIVRILLR 558



 Score = 33.5 bits (75), Expect = 0.49
 Identities = 22/72 (30%), Positives = 41/72 (56%), Gaps = 2/72 (2%)

Query: 306 LVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAV 365
           L+++L   D D+ A+D+     LHLA E   ++ A  LL+   + NL +++G T L +AV
Sbjct: 422 LMKILQPQDVDL-ALDSGASL-LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479

Query: 366 RSNHVSLVDMII 377
                 +V++++
Sbjct: 480 ERRVRGVVELLL 491


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  140 bits (354), Expect = 2e-33
 Identities = 107/361 (29%), Positives = 176/361 (48%), Gaps = 17/361 (4%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           L  AA   +V  ++ L+  + +  A++  G  AL +A   G+   V++LLE  A++++ +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGL-TLLHCAAQKGHV 137
             G             L+ +   GH+ + ++L+ +GA I+  S +   + L  A  KGH+
Sbjct: 365 ENGH----------TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414

Query: 138 PVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALH 197
            ++ F++E   D   +H      TA   A   G ++    L+ SG   N+      + L 
Sbjct: 415 EMVRFLLEAGADQ--EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472

Query: 198 LAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK 257
           LAA  GH+ +   L++ G  LEE N EG T L  AA   H + V LLL  G+ +NA T++
Sbjct: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532

Query: 258 NL-SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD 316
              + L  A   G  +V+  LI AG     ++   ++PL  A +     LV+ L+ + ++
Sbjct: 533 TQETALTLACCGGFLEVADFLIKAGAD---IELGCSTPLMEAAQEGHLELVKYLLAAGAN 589

Query: 317 VNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMI 376
           V+A      T L  A E+   D+AD+LL AG DL    + G+T L  A R+ HV  V  +
Sbjct: 590 VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649

Query: 377 I 377
           I
Sbjct: 650 I 650



 Score =  133 bits (334), Expect = 5e-31
 Identities = 107/367 (29%), Positives = 177/367 (48%), Gaps = 20/367 (5%)

Query: 17  RQLHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           R L EA  + +V  +++L+  GR VN       G   L  A  AG+ +  ++LL   A V
Sbjct: 236 RSLAEACSEGDVNAVRKLLIEGRSVNEHTEE--GESLLCLACSAGYYELAQVLLAMHANV 293

Query: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
           ++    G +T          L+ +A  GH++I+++L+   A ++ +S  G T L  A   
Sbjct: 294 EDRGIKGDITP---------LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344

Query: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE-GN 193
           G+V V+  ++E    +  DH +  G T    A   G ++    L+ +G   N    E   
Sbjct: 345 GYVDVVKVLLESGASIE-DHNEN-GHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE 402

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           +AL LA  +GH+ +++ L++ G D E +  E  TAL  A    H +  +LLL +G+ VN 
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
                 S L  AA  G  +++ +LI  G     V+ +G +PL  A R     +V LL+  
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522

Query: 314 DSDVNA-VDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSL 372
            +++NA  +  Q+T L LA    + ++AD L+ AG D+ L      T L  A +  H+ L
Sbjct: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLEL 579

Query: 373 VDMIIKA 379
           V  ++ A
Sbjct: 580 VKYLLAA 586



 Score =  127 bits (319), Expect = 2e-29
 Identities = 107/340 (31%), Positives = 159/340 (46%), Gaps = 18/340 (5%)

Query: 36  GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNAL 95
           G  +NT + N     AL  A   GH + VR LLE  A  D+E     +          AL
Sbjct: 390 GAGINTHS-NEFKESALTLACYKGHLEMVRFLLE--AGADQEHKTDEMH--------TAL 438

Query: 96  LLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHV 155
           + +   GH+ + ++L++SGA+++  +    + L  AA  GHV + A ++E     +L+ V
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE--RGASLEEV 496

Query: 156 DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN-TALHLAAGRGHMAVLQRLVDI 214
           +  G T    AA  G  + +  L+G G + N + +E   TAL LA   G + V   L+  
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556

Query: 215 GLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVS 274
           G D+E   +   T L  AA   H + V+ LL AG+ V+A T    + L YA  +G  DV+
Sbjct: 557 GADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVA 613

Query: 275 RVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN-AVDNRQQTPLHLAAE 333
            VL+ AG         G +PL  A R      V+ LI+  ++VN    N   T L LA  
Sbjct: 614 DVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACA 673

Query: 334 HAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
                + ++LL  G D   R K G T L  A +  H S+V
Sbjct: 674 GGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713



 Score =  116 bits (290), Expect = 6e-26
 Identities = 99/336 (29%), Positives = 154/336 (45%), Gaps = 22/336 (6%)

Query: 51   ALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQIL 110
            AL  A   GHE+ V+ LLE  A+++  D  G             L+L+A  GH+ +++IL
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKG----------FTPLILAATAGHVGVVEIL 1135

Query: 111  VNSGAKIHCES---KDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAA 167
            +++GA I  +S   KD  T L  A   G   V+  ++        +H +    T    AA
Sbjct: 1136 LDNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLA--RGANKEHRNVSDYTPLSLAA 1191

Query: 168  EHGQLDALDFLVGSGCDHNVK--DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQ-NAE 224
              G ++ +  L+ +G + N +   K G + L LAA  GH A ++ L+D+G D+  Q    
Sbjct: 1192 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1251

Query: 225  GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284
              TAL  A      + V LLL   + V    +  L+ L  AA  G  +V RVL+  G   
Sbjct: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311

Query: 285  NV--VDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADM 342
            N   V     + L +A          LLI   + ++  + +  TPL LAA     D+  +
Sbjct: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371

Query: 343  LLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
            L+ AG D++  D +  T L  A R  HV +V  ++K
Sbjct: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  113 bits (283), Expect = 4e-25
 Identities = 79/291 (27%), Positives = 144/291 (49%), Gaps = 6/291 (2%)

Query: 94   ALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALD 153
            AL L+   GH  ++Q L+  GA I    K G T L  AA  GHV V+  ++++  D+   
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145

Query: 154  HVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD 213
              ++   T    A   G+ + ++ L+  G +   ++    T L LAA  G++ +++ L++
Sbjct: 1146 S-ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204

Query: 214  IGLDLEEQNAE--GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLS-CLHYAALSGS 270
             G ++  +     G++ L  AA   H   V+LLL  GS +NA  + N +  L  A   G 
Sbjct: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264

Query: 271  EDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNA--VDNRQQTPL 328
             +V  +L+            G +PL  A    +  + R+L++  +DVNA  V + + T L
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1324

Query: 329  HLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
             +AA+       ++L+  G  +++R+K+G T L +A    H+ +V ++++A
Sbjct: 1325 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1375



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 72/248 (29%), Positives = 121/248 (48%), Gaps = 13/248 (5%)

Query: 34   LIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMN 93
            L+ R  N   RN      L  AA  G+   +++LL   A ++        T ++L  G++
Sbjct: 1169 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR------TGSKL--GIS 1220

Query: 94   ALLLSAWFGHLRILQILVNSGAKIHCESKDGL-TLLHCAAQKGHVPVLAFIMEDLEDVAL 152
             L+L+A  GH   +++L++ G+ I+ + +    T L  A  +G   V++ +++   +V  
Sbjct: 1221 PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANV-- 1278

Query: 153  DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKD--KEGNTALHLAAGRGHMAVLQR 210
            +H  K G T    AA  G  +    L+  G D N        +TAL +AA +GH    + 
Sbjct: 1279 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1338

Query: 211  LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 270
            L+  G  ++ +N +G T L  AA G H D VQLL++AG+ V+A   + ++ L  A   G 
Sbjct: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1398

Query: 271  EDVSRVLI 278
              V R L+
Sbjct: 1399 VKVVRYLV 1406



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 69/231 (29%), Positives = 111/231 (48%), Gaps = 13/231 (5%)

Query: 36   GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNAL 95
            G  +N+R  + +G   L  AA  GH  AV+LLL+  + ++ +      T         AL
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT---------AL 1256

Query: 96   LLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHV 155
             L+ + G   ++ +L++  A +   +K GLT L  AA  G+  V   +++   DV    V
Sbjct: 1257 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316

Query: 156  DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 215
                 TA   AA+ G     + L+G G   +V++K+GNT L LAA  GH+ V+Q LV  G
Sbjct: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376

Query: 216  LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAA 266
             D++  +   +T L +A    H   V+ L++    VN     +  C+ Y A
Sbjct: 1377 ADVDAADNRKITPLMAAFRKGHVKVVRYLVK---EVNQFPSDS-ECMRYIA 1423



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 66/216 (30%), Positives = 103/216 (47%), Gaps = 4/216 (1%)

Query: 161  TAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEE 220
            TA   A   G  + +  L+  G     +DK+G T L LAA  GH+ V++ L+D G D+E 
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 221  QNAEGL-TALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
            Q+     T L  A  G   + V+LLL  G+        + + L  AA  G  ++ ++L++
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204

Query: 280  AGGCAN--VVDHQGASPLHLAVRHNFPALVRLLINSDSDVNA-VDNRQQTPLHLAAEHAW 336
            AG   N       G SPL LA  +   A V+LL++  SD+NA ++  + T L LA     
Sbjct: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264

Query: 337  QDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSL 372
             ++  +LL    ++  R K G T L  A    +  +
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1300



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 79/253 (31%), Positives = 111/253 (43%), Gaps = 26/253 (10%)

Query: 16  ERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75
           E  L  AA   +V     LI R  +    N  G   L  AA  GHE+ V LLL   A ++
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527

Query: 76  ---EEDAVGALTEARLCFGM-------------------NALLLSAWFGHLRILQILVNS 113
              EE    ALT A  C G                      L+ +A  GHL +++ L+ +
Sbjct: 528 AQTEETQETALTLA-CCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAA 586

Query: 114 GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLD 173
           GA +H  +  G T L  A + GH  V   +++   D  L+H  + GRT   +AA  G + 
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGAD--LEHESEGGRTPLMKAARAGHVC 644

Query: 174 ALDFLVGSGCDHN-VKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSA 232
            + FL+  G + N       +T L LA   GH+AV++ L+  G D   +  +G T L  A
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704

Query: 233 AGGSHPDCVQLLL 245
           A G H   V  LL
Sbjct: 705 AKGGHTSVVCYLL 717



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 50/189 (26%), Positives = 95/189 (50%), Gaps = 4/189 (2%)

Query: 193  NTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVN 252
            +TAL LA   GH  ++Q L++ G  +E ++ +G T L  AA   H   V++LL  G+ + 
Sbjct: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 1143

Query: 253  ALTQKNLSC-LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLI 311
            A +++     L  A   G ++V  +L+  G      +    +PL LA    +  ++++L+
Sbjct: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203

Query: 312  NSDSDVNAVDNRQQ--TPLHLAAEHAWQDIADMLLIAGVDLNLR-DKQGKTALAVAVRSN 368
            N+ +++N+    +   +PL LAA +       +LL  G D+N + +    TAL +A    
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263

Query: 369  HVSLVDMII 377
               +V +++
Sbjct: 1264 RTEVVSLLL 1272



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 49/159 (30%), Positives = 73/159 (45%), Gaps = 11/159 (6%)

Query: 55  AAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSG 114
           AA  GH + V+ LL          A GA   A    G  AL  +   GH  +  +L+ +G
Sbjct: 571 AAQEGHLELVKYLL----------AAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620

Query: 115 AKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA 174
           A +  ES+ G T L  AA+ GHV  + F++    +V     +    T    A   G L  
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANN-DHTVLSLACAGGHLAV 679

Query: 175 LDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD 213
           ++ L+  G D   + K+G+T L  AA  GH +V+  L+D
Sbjct: 680 VELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 40/151 (26%), Positives = 66/151 (43%), Gaps = 24/151 (15%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           L EAA++ ++  ++ L+    N  A    G  AL +A   GH     +LL+  A ++ E 
Sbjct: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627

Query: 79  AVG------ALTEARLCF-------GMNA-----------LLLSAWFGHLRILQILVNSG 114
             G      A     +C        G N            L L+   GHL ++++L+  G
Sbjct: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687

Query: 115 AKIHCESKDGLTLLHCAAQKGHVPVLAFIME 145
           A      KDG T+L  AA+ GH  V+ ++++
Sbjct: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718



 Score = 37.0 bits (84), Expect = 0.044
 Identities = 19/63 (30%), Positives = 35/63 (55%), Gaps = 1/63 (1%)

Query: 316  DVNA-VDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVD 374
            D++A  ++   T L LA     +++   LL  G  +  RDK+G T L +A  + HV +V+
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 375  MII 377
            +++
Sbjct: 1134 ILL 1136


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  140 bits (354), Expect = 2e-33
 Identities = 107/361 (29%), Positives = 176/361 (48%), Gaps = 17/361 (4%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           L  AA   +V  ++ L+  + +  A++  G  AL +A   G+   V++LLE  A++++ +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGL-TLLHCAAQKGHV 137
             G             L+ +   GH+ + ++L+ +GA I+  S +   + L  A  KGH+
Sbjct: 365 ENGH----------TPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414

Query: 138 PVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALH 197
            ++ F++E   D   +H      TA   A   G ++    L+ SG   N+      + L 
Sbjct: 415 EMVRFLLEAGADQ--EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472

Query: 198 LAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK 257
           LAA  GH+ +   L++ G  LEE N EG T L  AA   H + V LLL  G+ +NA T++
Sbjct: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532

Query: 258 NL-SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD 316
              + L  A   G  +V+  LI AG     ++   ++PL  A +     LV+ L+ + ++
Sbjct: 533 TQETALTLACCGGFLEVADFLIKAGAD---IELGCSTPLMEAAQEGHLELVKYLLAAGAN 589

Query: 317 VNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMI 376
           V+A      T L  A E+   D+AD+LL AG DL    + G+T L  A R+ HV  V  +
Sbjct: 590 VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649

Query: 377 I 377
           I
Sbjct: 650 I 650



 Score =  133 bits (334), Expect = 5e-31
 Identities = 107/367 (29%), Positives = 177/367 (48%), Gaps = 20/367 (5%)

Query: 17  RQLHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           R L EA  + +V  +++L+  GR VN       G   L  A  AG+ +  ++LL   A V
Sbjct: 236 RSLAEACSEGDVNAVRKLLIEGRSVNEHTEE--GESLLCLACSAGYYELAQVLLAMHANV 293

Query: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
           ++    G +T          L+ +A  GH++I+++L+   A ++ +S  G T L  A   
Sbjct: 294 EDRGIKGDITP---------LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344

Query: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE-GN 193
           G+V V+  ++E    +  DH +  G T    A   G ++    L+ +G   N    E   
Sbjct: 345 GYVDVVKVLLESGASIE-DHNEN-GHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE 402

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           +AL LA  +GH+ +++ L++ G D E +  E  TAL  A    H +  +LLL +G+ VN 
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
                 S L  AA  G  +++ +LI  G     V+ +G +PL  A R     +V LL+  
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522

Query: 314 DSDVNA-VDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSL 372
            +++NA  +  Q+T L LA    + ++AD L+ AG D+ L      T L  A +  H+ L
Sbjct: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLEL 579

Query: 373 VDMIIKA 379
           V  ++ A
Sbjct: 580 VKYLLAA 586



 Score =  127 bits (319), Expect = 2e-29
 Identities = 107/340 (31%), Positives = 159/340 (46%), Gaps = 18/340 (5%)

Query: 36  GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNAL 95
           G  +NT + N     AL  A   GH + VR LLE  A  D+E     +          AL
Sbjct: 390 GAGINTHS-NEFKESALTLACYKGHLEMVRFLLE--AGADQEHKTDEMH--------TAL 438

Query: 96  LLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHV 155
           + +   GH+ + ++L++SGA+++  +    + L  AA  GHV + A ++E     +L+ V
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE--RGASLEEV 496

Query: 156 DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN-TALHLAAGRGHMAVLQRLVDI 214
           +  G T    AA  G  + +  L+G G + N + +E   TAL LA   G + V   L+  
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556

Query: 215 GLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVS 274
           G D+E   +   T L  AA   H + V+ LL AG+ V+A T    + L YA  +G  DV+
Sbjct: 557 GADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVA 613

Query: 275 RVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN-AVDNRQQTPLHLAAE 333
            VL+ AG         G +PL  A R      V+ LI+  ++VN    N   T L LA  
Sbjct: 614 DVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACA 673

Query: 334 HAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
                + ++LL  G D   R K G T L  A +  H S+V
Sbjct: 674 GGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713



 Score =  116 bits (290), Expect = 6e-26
 Identities = 99/336 (29%), Positives = 154/336 (45%), Gaps = 22/336 (6%)

Query: 51   ALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQIL 110
            AL  A   GHE+ V+ LLE  A+++  D  G             L+L+A  GH+ +++IL
Sbjct: 835  ALTLACAGGHEELVQTLLERGASIEHRDKKG----------FTPLILAATAGHVGVVEIL 884

Query: 111  VNSGAKIHCES---KDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAA 167
            +++GA I  +S   KD  T L  A   G   V+  ++        +H +    T    AA
Sbjct: 885  LDNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLA--RGANKEHRNVSDYTPLSLAA 940

Query: 168  EHGQLDALDFLVGSGCDHNVK--DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQ-NAE 224
              G ++ +  L+ +G + N +   K G + L LAA  GH A ++ L+D+G D+  Q    
Sbjct: 941  SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1000

Query: 225  GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284
              TAL  A      + V LLL   + V    +  L+ L  AA  G  +V RVL+  G   
Sbjct: 1001 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1060

Query: 285  NV--VDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADM 342
            N   V     + L +A          LLI   + ++  + +  TPL LAA     D+  +
Sbjct: 1061 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120

Query: 343  LLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
            L+ AG D++  D +  T L  A R  HV +V  ++K
Sbjct: 1121 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156



 Score =  113 bits (283), Expect = 4e-25
 Identities = 79/291 (27%), Positives = 144/291 (49%), Gaps = 6/291 (2%)

Query: 94   ALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALD 153
            AL L+   GH  ++Q L+  GA I    K G T L  AA  GHV V+  ++++  D+   
Sbjct: 835  ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894

Query: 154  HVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD 213
              ++   T    A   G+ + ++ L+  G +   ++    T L LAA  G++ +++ L++
Sbjct: 895  S-ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 953

Query: 214  IGLDLEEQNAE--GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLS-CLHYAALSGS 270
             G ++  +     G++ L  AA   H   V+LLL  GS +NA  + N +  L  A   G 
Sbjct: 954  AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1013

Query: 271  EDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNA--VDNRQQTPL 328
             +V  +L+            G +PL  A    +  + R+L++  +DVNA  V + + T L
Sbjct: 1014 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1073

Query: 329  HLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
             +AA+       ++L+  G  +++R+K+G T L +A    H+ +V ++++A
Sbjct: 1074 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1124



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 72/248 (29%), Positives = 121/248 (48%), Gaps = 13/248 (5%)

Query: 34   LIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMN 93
            L+ R  N   RN      L  AA  G+   +++LL   A ++        T ++L  G++
Sbjct: 918  LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR------TGSKL--GIS 969

Query: 94   ALLLSAWFGHLRILQILVNSGAKIHCESKDGL-TLLHCAAQKGHVPVLAFIMEDLEDVAL 152
             L+L+A  GH   +++L++ G+ I+ + +    T L  A  +G   V++ +++   +V  
Sbjct: 970  PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANV-- 1027

Query: 153  DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKD--KEGNTALHLAAGRGHMAVLQR 210
            +H  K G T    AA  G  +    L+  G D N        +TAL +AA +GH    + 
Sbjct: 1028 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1087

Query: 211  LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 270
            L+  G  ++ +N +G T L  AA G H D VQLL++AG+ V+A   + ++ L  A   G 
Sbjct: 1088 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1147

Query: 271  EDVSRVLI 278
              V R L+
Sbjct: 1148 VKVVRYLV 1155



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 69/231 (29%), Positives = 111/231 (48%), Gaps = 13/231 (5%)

Query: 36   GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNAL 95
            G  +N+R  + +G   L  AA  GH  AV+LLL+  + ++ +      T         AL
Sbjct: 955  GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT---------AL 1005

Query: 96   LLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHV 155
             L+ + G   ++ +L++  A +   +K GLT L  AA  G+  V   +++   DV    V
Sbjct: 1006 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1065

Query: 156  DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 215
                 TA   AA+ G     + L+G G   +V++K+GNT L LAA  GH+ V+Q LV  G
Sbjct: 1066 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1125

Query: 216  LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAA 266
             D++  +   +T L +A    H   V+ L++    VN     +  C+ Y A
Sbjct: 1126 ADVDAADNRKITPLMAAFRKGHVKVVRYLVK---EVNQFPSDS-ECMRYIA 1172



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 66/216 (30%), Positives = 103/216 (47%), Gaps = 4/216 (1%)

Query: 161  TAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEE 220
            TA   A   G  + +  L+  G     +DK+G T L LAA  GH+ V++ L+D G D+E 
Sbjct: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893

Query: 221  QNAEGL-TALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
            Q+     T L  A  G   + V+LLL  G+        + + L  AA  G  ++ ++L++
Sbjct: 894  QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 953

Query: 280  AGGCAN--VVDHQGASPLHLAVRHNFPALVRLLINSDSDVNA-VDNRQQTPLHLAAEHAW 336
            AG   N       G SPL LA  +   A V+LL++  SD+NA ++  + T L LA     
Sbjct: 954  AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1013

Query: 337  QDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSL 372
             ++  +LL    ++  R K G T L  A    +  +
Sbjct: 1014 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1049



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 79/253 (31%), Positives = 111/253 (43%), Gaps = 26/253 (10%)

Query: 16  ERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75
           E  L  AA   +V     LI R  +    N  G   L  AA  GHE+ V LLL   A ++
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527

Query: 76  ---EEDAVGALTEARLCFGM-------------------NALLLSAWFGHLRILQILVNS 113
              EE    ALT A  C G                      L+ +A  GHL +++ L+ +
Sbjct: 528 AQTEETQETALTLA-CCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAA 586

Query: 114 GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLD 173
           GA +H  +  G T L  A + GH  V   +++   D  L+H  + GRT   +AA  G + 
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQAGAD--LEHESEGGRTPLMKAARAGHVC 644

Query: 174 ALDFLVGSGCDHN-VKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSA 232
            + FL+  G + N       +T L LA   GH+AV++ L+  G D   +  +G T L  A
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704

Query: 233 AGGSHPDCVQLLL 245
           A G H   V  LL
Sbjct: 705 AKGGHTSVVCYLL 717



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 98/421 (23%), Positives = 165/421 (39%), Gaps = 63/421 (14%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           L EAA++ ++  ++ L+    N  A    G  AL +A   GH     +LL+  A ++ E 
Sbjct: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627

Query: 79  AVG------ALTEARLCF-------GMNA-----------LLLSAWFGHLRILQILVNSG 114
             G      A     +C        G N            L L+   GHL ++++L+  G
Sbjct: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687

Query: 115 AKIHCESKDGLTLLHCAAQKGHVPVLAFIME-----------DLEDVA-----LDHVDKL 158
           A      KDG T+L  AA+ GH  V+ ++++           D+  +      L+   ++
Sbjct: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRV 747

Query: 159 GRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEG------NTALHLAAGR---------- 202
              A        + D     V +      K   G      NT  H  A            
Sbjct: 748 PVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPS 807

Query: 203 ---GHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNL 259
                 A+L     I +D + ++        + AGG H + VQ LL  G+++    +K  
Sbjct: 808 PIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGG-HEELVQTLLERGASIEHRDKKGF 866

Query: 260 SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGA-SPLHLAVRHNFPALVRLLINSDSDVN 318
           + L  AA +G   V  +L+  G        +   +PL LA       +V LL+   ++  
Sbjct: 867 TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE 926

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLR--DKQGKTALAVAVRSNHVSLVDMI 376
             +    TPL LAA   + +I  +LL AG ++N R   K G + L +A  + H + V ++
Sbjct: 927 HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986

Query: 377 I 377
           +
Sbjct: 987 L 987



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 50/189 (26%), Positives = 95/189 (50%), Gaps = 4/189 (2%)

Query: 193  NTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVN 252
            +TAL LA   GH  ++Q L++ G  +E ++ +G T L  AA   H   V++LL  G+ + 
Sbjct: 833  DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 892

Query: 253  ALTQKNLSC-LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLI 311
            A +++     L  A   G ++V  +L+  G      +    +PL LA    +  ++++L+
Sbjct: 893  AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 952

Query: 312  NSDSDVNAVDNRQQ--TPLHLAAEHAWQDIADMLLIAGVDLNLR-DKQGKTALAVAVRSN 368
            N+ +++N+    +   +PL LAA +       +LL  G D+N + +    TAL +A    
Sbjct: 953  NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012

Query: 369  HVSLVDMII 377
               +V +++
Sbjct: 1013 RTEVVSLLL 1021


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  139 bits (349), Expect = 8e-33
 Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 12/326 (3%)

Query: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
           L  A+++ +V  ++EL+   VN   R+  G  AL WA   G    V LLL H        
Sbjct: 75  LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSH-------- 126

Query: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
             GA       + +  ++ +A  GH  I+ +L+ +GAK++C  K G T L  AA+KGH+ 
Sbjct: 127 --GANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLE 184

Query: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198
            +  ++    DV  +  + +  TA   A + G   ++  ++    + N+ DK+GNTAL +
Sbjct: 185 CVKHLLAMGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMI 242

Query: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258
           A+  GH  ++Q L+D G  +   +  G T L  A  G H + V+ LL+  + ++   Q N
Sbjct: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302

Query: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318
            + L++A   G+  + R ++       +    G +PL  A +     +V LL++  + V+
Sbjct: 303 KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362

Query: 319 AVDNRQQTPLHLAAEHAWQDIADMLL 344
           AVD +  TPLH+A     + +A++LL
Sbjct: 363 AVDKKGDTPLHIAIRGRSRKLAELLL 388



 Score =  116 bits (291), Expect = 4e-26
 Identities = 86/353 (24%), Positives = 164/353 (46%), Gaps = 12/353 (3%)

Query: 25  QNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALT 84
           + N+  ++ L+ +  +   RN  G+  L  AA  G+ + V+ L+++ A  + ED      
Sbjct: 15  EENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDN--- 71

Query: 85  EARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIM 144
                    AL+ ++  GH+ I++ L+  G  +      G T L  A  KG   V+  ++
Sbjct: 72  -------WTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL 124

Query: 145 EDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGH 204
               + ++  +  +    +  AA  G  D +  L+ +G   N  DK G T L  AA +GH
Sbjct: 125 SHGANPSVTGLYSVYPIIW--AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH 182

Query: 205 MAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHY 264
           +  ++ L+ +G D++++ A  +TAL  A  G +   V+ +L+    VN   +   + L  
Sbjct: 183 LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMI 242

Query: 265 AALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQ 324
           A+  G  ++ + L+ AG   N+ D  G + L  AVR     +VR L+   +D++      
Sbjct: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302

Query: 325 QTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
           +T L+ A E     +   +L    D  +  K G+T L  A +  ++ +V++++
Sbjct: 303 KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLL 355



 Score =  108 bits (271), Expect = 9e-24
 Identities = 71/250 (28%), Positives = 126/250 (50%), Gaps = 2/250 (0%)

Query: 133 QKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEG 192
           ++ ++P L  ++E  +DV  D  ++ G+T    AAE G L+ +  L+ +G + N++D + 
Sbjct: 14  EEENIPALKALLEKCKDV--DERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDN 71

Query: 193 NTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVN 252
            TAL  A+  GH+ +++ L+  G++LE ++  G TAL  A      D V+LLL  G+  +
Sbjct: 72  WTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPS 131

Query: 253 ALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLIN 312
                ++  + +AA  G  D+  +L+  G   N  D  G +PL  A R      V+ L+ 
Sbjct: 132 VTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191

Query: 313 SDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSL 372
             +DV+       T L +A +  +      +L    ++NL DK G TAL +A +  H  +
Sbjct: 192 MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEI 251

Query: 373 VDMIIKADRF 382
           V  ++ A  +
Sbjct: 252 VQDLLDAGTY 261



 Score =  107 bits (268), Expect = 2e-23
 Identities = 86/318 (27%), Positives = 150/318 (47%), Gaps = 12/318 (3%)

Query: 63  AVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESK 122
           A++ LLE    VDE +  G             L+++A  G+L I++ L+ +GA  + E  
Sbjct: 20  ALKALLEKCKDVDERNECG----------QTPLMIAAEQGNLEIVKELIKNGANCNLEDL 69

Query: 123 DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG 182
           D  T L  A+++GHV ++  +++    V L+H D  G TA   A   G+ D ++ L+  G
Sbjct: 70  DNWTALISASKEGHVHIVEELLKC--GVNLEHRDMGGWTALMWACYKGRTDVVELLLSHG 127

Query: 183 CDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQ 242
            + +V        +  AAGRGH  ++  L+  G  +   +  G T L  AA   H +CV+
Sbjct: 128 ANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVK 187

Query: 243 LLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHN 302
            LL  G+ V+     +++ L  A   G     + ++      N+ D  G + L +A +  
Sbjct: 188 HLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEG 247

Query: 303 FPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALA 362
              +V+ L+++ + VN  D    T L  A      +I   LL    D+++R +  KTAL 
Sbjct: 248 HTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALY 307

Query: 363 VAVRSNHVSLVDMIIKAD 380
            AV   + ++V  I++ +
Sbjct: 308 WAVEKGNATMVRDILQCN 325


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  137 bits (345), Expect = 2e-32
 Identities = 114/363 (31%), Positives = 167/363 (46%), Gaps = 21/363 (5%)

Query: 2   QEELAWETDGLLPLERQLH--EAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAG 59
           +E L   T+G   ++   H  +A  +   G + +L+ +  +   R+H GR  LH A   G
Sbjct: 26  EEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRG 85

Query: 60  HEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHC 119
           H   VRLLL+  A V      GA+  A    G  AL  +AW GH R+ ++L+  GA    
Sbjct: 86  HAPLVRLLLQRGAPV------GAVDRA----GRTALHEAAWHGHSRVAELLLQRGASAAA 135

Query: 120 ESKDGLTLLHCAAQKGHVPVLAFIME--DLEDVALDHVDKLGRTAFHRAAEHGQLDALDF 177
            S  GLT LH AA  GH  + A ++E       A +  D  G TA H AA  G+L  L+ 
Sbjct: 136 RSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLEL 195

Query: 178 LVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSH 237
           L   G        +G   +  AAGRG  A L+ L+  G  ++ ++  G TAL  AA    
Sbjct: 196 LAAGGAG-----LDGALLVAAAAGRG--AALRFLLARGARVDARDGAGATALGLAAALGR 248

Query: 238 PDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHL 297
              +++LL  G+      +   S LH AA  G     ++L+  G   +  D  G +PLH 
Sbjct: 249 SQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHH 308

Query: 298 AVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQG 357
           A R     +   L++  + V+A    ++TPLHLAAE        +LL  G    LR +  
Sbjct: 309 ASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWA 368

Query: 358 KTA 360
           + A
Sbjct: 369 EVA 371



 Score =  119 bits (298), Expect = 7e-27
 Identities = 94/335 (28%), Positives = 140/335 (41%), Gaps = 33/335 (9%)

Query: 74  VDEEDAVGALTEA-RLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAA 132
           +D E+A+G  TE   +  G   LL + W G   ++  L+  GA +      G T LH A 
Sbjct: 23  LDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAV 82

Query: 133 QKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEG 192
            +GH P++  +++      +  VD+ GRTA H AA HG     + L+  G     +   G
Sbjct: 83  LRGHAPLVRLLLQ--RGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTG 140

Query: 193 NTALHLAAGRGHMAVLQRLVDIG----LDLEEQNAEGLTALHSAAGGSHPDCVQLL---- 244
            T LH AA  GH  +  RL++         E ++A G TA H AA G     ++LL    
Sbjct: 141 LTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGG 200

Query: 245 ----------------------LRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGG 282
                                 L  G+ V+A      + L  AA  G      VL+  G 
Sbjct: 201 AGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGA 260

Query: 283 CANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADM 342
              + D  G S LH A        V+LL+   ++V+A D    TPLH A+     ++A  
Sbjct: 261 DPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGC 320

Query: 343 LLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
           LL  G  ++      KT L +A    H   V +++
Sbjct: 321 LLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLL 355



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 38/103 (36%), Positives = 49/103 (47%)

Query: 277 LIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAW 336
           L+  G      DH G +PLHLAV      LVRLL+   + V AVD   +T LH AA H  
Sbjct: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119

Query: 337 QDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
             +A++LL  G     R   G T L  A    H  L   +++A
Sbjct: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 26/89 (29%), Positives = 41/89 (46%)

Query: 290 QGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVD 349
           QG   L  AV      LV  L+   + V   D+  +TPLHLA       +  +LL  G  
Sbjct: 40  QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAP 99

Query: 350 LNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
           +   D+ G+TAL  A    H  + +++++
Sbjct: 100 VGAVDRAGRTALHEAAWHGHSRVAELLLQ 128


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  136 bits (342), Expect = 5e-32
 Identities = 114/381 (29%), Positives = 173/381 (45%), Gaps = 49/381 (12%)

Query: 32  QELIGRRVNTRARNHVGRVA-LHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCF 90
           Q L+    N   R + G +  L  A+  G+   V+LLL H+A V+ + A G       C 
Sbjct: 255 QVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 314

Query: 91  GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDV 150
           G          G + I+++L+N GA I   +++G T L  AA  GHV V   +++    +
Sbjct: 315 G----------GFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364

Query: 151 ALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALH------------- 197
              H ++   +A   A   G LD + FL+ +G D   K  E +TAL              
Sbjct: 365 NT-HSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423

Query: 198 --------------------LAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSH 237
                               LAA  GH+ +   L++ G +LEE N EG T L  AA   H
Sbjct: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 483

Query: 238 PDCVQLLLRAGSTVNALTQKNL-SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLH 296
            + V LLL  G+ +NA T++   + L  A   G  +V+  LI AG     ++   ++PL 
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLM 540

Query: 297 LAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQ 356
            A +     LV+ L+ S ++V+A      T L  A E+   D+AD+LL AG DL    + 
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600

Query: 357 GKTALAVAVRSNHVSLVDMII 377
           G+T L  A R+ H+  V  +I
Sbjct: 601 GRTPLMKAARAGHLCTVQFLI 621



 Score =  123 bits (308), Expect = 5e-28
 Identities = 104/365 (28%), Positives = 174/365 (47%), Gaps = 20/365 (5%)

Query: 17  RQLHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           R L EA    +V  +++L+  GR VN       G   L  A  AG+ +  ++LL   A V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEE--GESLLCLACSAGYYELAQVLLAMHANV 264

Query: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
           ++    G +T          L+ ++  G+L I+++L+   A ++ +S  G T L  A   
Sbjct: 265 EDRGNKGDITP---------LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAG 315

Query: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE-GN 193
           G V ++  ++ +  ++  DH +  G T    AA  G ++    L+  G   N    E   
Sbjct: 316 GFVDIVKVLLNEGANIE-DHNEN-GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 373

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           +AL LA  +GH+ +++ L++ G D E +  E  TAL  A    H +  +LLL +G+ VN 
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
                 S L  AA  G  +++ +LI  G     V+ +G +PL  A R     +V LL+  
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493

Query: 314 DSDVNA-VDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSL 372
            +++NA  +  Q+T L LA    + ++AD L+ AG D+ L      T L  A +  H+ L
Sbjct: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLEL 550

Query: 373 VDMII 377
           V  ++
Sbjct: 551 VKYLL 555



 Score =  123 bits (308), Expect = 5e-28
 Identities = 106/370 (28%), Positives = 166/370 (44%), Gaps = 31/370 (8%)

Query: 34  LIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD------EEDAV------- 80
           L+    N    N  G   L  AA AGH +  R+LL+H A ++      +E A+       
Sbjct: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 81  -----------GALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLH 129
                      GA  E +      AL+ +   GH+ + ++L++SGA+++  +    + L 
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 130 CAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKD 189
            AA  GHV + A ++E      L+ V+  G T    AA  G  + +  L+  G + N + 
Sbjct: 444 LAACGGHVELAALLIE--RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501

Query: 190 KEGN-TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG 248
           +E   TAL LA   G   V   L+  G D+E   +   T L  A+   H + V+ LL +G
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 558

Query: 249 STVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVR 308
           + V+A T    + L YA  +G  DV+ VL+ AG         G +PL  A R      V+
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618

Query: 309 LLINSDSDVN-AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRS 367
            LI+  ++VN A  N   T + LA       + ++LL  G D   R K G T L  A + 
Sbjct: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678

Query: 368 NHVSLVDMII 377
            H ++V  ++
Sbjct: 679 GHTNVVSYLL 688



 Score =  111 bits (278), Expect = 1e-24
 Identities = 79/291 (27%), Positives = 142/291 (48%), Gaps = 6/291 (2%)

Query: 94   ALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALD 153
            AL L+   GH  ++ +L+   AKI    K G T L  AA  GHV V+  +++   D+   
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117

Query: 154  HVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD 213
              ++   T    A   G+ + +D L+  G +   ++    T L LAA  G++ +++ L++
Sbjct: 1118 S-ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 214  IGLDLEEQNAE--GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLS-CLHYAALSGS 270
             G ++  +     G++ L  AA   H   V+LLL  GS +NA  + N +  L  A   G 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 271  EDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNA--VDNRQQTPL 328
             +V  +L+            G +PL  A    +  + R+L++  +DVNA  V + + T L
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 329  HLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
             +AA+       ++L+  G  +++R+K+G T L +A    H  +V ++++A
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA 1347



 Score =  109 bits (272), Expect = 7e-24
 Identities = 94/336 (27%), Positives = 152/336 (45%), Gaps = 22/336 (6%)

Query: 51   ALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQIL 110
            AL  A   GHE+ V +L+  +A ++  D  G             L+L+A  GH+ +++IL
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKG----------FTPLILAATAGHVGVVEIL 1107

Query: 111  VNSGAKIHCES---KDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAA 167
            ++ G  I  +S   KD  T L  A   G   V+  ++        +H +    T    AA
Sbjct: 1108 LDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLA--RGANKEHRNVSDYTPLSLAA 1163

Query: 168  EHGQLDALDFLVGSGCDHNVK--DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQ-NAE 224
              G ++ +  L+ +G + N +   K G + L LAA  GH+  ++ L+D+G D+  Q    
Sbjct: 1164 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETN 1223

Query: 225  GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284
              TAL  A      + V LLL   + V    +  L+ L  AA  G  +V RVL+  G   
Sbjct: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 285  NV--VDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADM 342
            N   V     + L +A          LLI+  + ++  + +  TPL LA+     D+  +
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 343  LLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
            L+ AG D++  D +  T L  A R  HV +V  ++K
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 88/287 (30%), Positives = 128/287 (44%), Gaps = 27/287 (9%)

Query: 16  ERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75
           E  L  AA   +V     LI R  N    N  G   L  AA  GHE+ V LLL   A ++
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498

Query: 76  ---EEDAVGALTEARLCFGMNA-------------------LLLSAWFGHLRILQILVNS 113
              EE    ALT A  C G +                    L+ ++  GHL +++ L+ S
Sbjct: 499 AQTEETQETALTLA-CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAS 557

Query: 114 GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLD 173
           GA +H  +  G T L  A + GH  V   +++   D  L+H  + GRT   +AA  G L 
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGAD--LEHESEGGRTPLMKAARAGHLC 615

Query: 174 ALDFLVGSGCDHN-VKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSA 232
            + FL+  G + N       +T + LA   GH+AV++ L+  G D   +  +G T L  A
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 675

Query: 233 AGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
           A G H + V  LL   + V ++   ++S L   +   S+ V RV  H
Sbjct: 676 AKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQ-VPRVPTH 721



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 70/248 (28%), Positives = 122/248 (49%), Gaps = 13/248 (5%)

Query: 34   LIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMN 93
            L+ R  N   RN      L  AA  G+   +++LL   A ++        T ++L  G++
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR------TGSKL--GIS 1192

Query: 94   ALLLSAWFGHLRILQILVNSGAKIHCESKDGL-TLLHCAAQKGHVPVLAFIMEDLEDVAL 152
             L+L+A  GH+  +++L++ G+ I+ + +    T L  A  +G   V++ +++   +V  
Sbjct: 1193 PLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANV-- 1250

Query: 153  DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKD--KEGNTALHLAAGRGHMAVLQR 210
            +H  K G T    AA  G  +    L+  G D N        +TAL +AA +GH    + 
Sbjct: 1251 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1310

Query: 211  LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 270
            L+  G  ++ +N +G T L  A+ G H D VQLL++AG+ V+A   + ++ L  A   G 
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGH 1370

Query: 271  EDVSRVLI 278
              V + L+
Sbjct: 1371 VKVVQYLV 1378



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 69/231 (29%), Positives = 110/231 (47%), Gaps = 13/231 (5%)

Query: 36   GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNAL 95
            G  +N+R  + +G   L  AA  GH  AV+LLL+  + ++ +      T         AL
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT---------AL 1228

Query: 96   LLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHV 155
             L+ + G   ++ +L++  A +   +K GLT L  AA  G+  V   +++   DV    V
Sbjct: 1229 TLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1288

Query: 156  DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 215
                 TA   AA+ G     + L+  G   +V++K+GNT L LA+  GH  V+Q LV  G
Sbjct: 1289 PSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 1348

Query: 216  LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAA 266
             D++  +   +T L SA    H   VQ L++    VN     ++ C+ Y A
Sbjct: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVNQF-PSDIECMRYIA 1395



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 99/348 (28%), Positives = 144/348 (41%), Gaps = 80/348 (22%)

Query: 19  LHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDE 76
           L EAA   +V   + L+  G  +NT + N     AL  A   GH   VR LLE  A  D+
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHLDMVRFLLE--AGADQ 398

Query: 77  EDAV-------------GALTEARLCFGMNA------------LLLSAWFGHLRILQILV 111
           E                G +  ARL     A            L L+A  GH+ +  +L+
Sbjct: 399 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 458

Query: 112 NSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIM----------EDLEDVAL--------- 152
             GA +   + +G T L  AA++GH  ++A ++          E+ ++ AL         
Sbjct: 459 ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFS 518

Query: 153 ---DHVDKLGR-------TAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGR 202
              D + K G        T    A++ G L+ + +L+ SG + +     G+TAL  A   
Sbjct: 519 EVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578

Query: 203 GHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN---- 258
           GH  V   L+  G DLE ++  G T L  AA   H   VQ L+  G+ VN  T  N    
Sbjct: 579 GHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTV 638

Query: 259 --LSCL--HYAALS-----GSE------DVSRVLIHA--GGCANVVDH 289
             L+C   H A +      G++      D S +LI A  GG  NVV +
Sbjct: 639 VSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSY 686



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 65/223 (29%), Positives = 102/223 (45%), Gaps = 4/223 (1%)

Query: 154  HVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD 213
            H +    TA   A   G  + +  L+        +DK+G T L LAA  GH+ V++ L+D
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109

Query: 214  IGLDLEEQNAEGL-TALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSED 272
             G D+E Q+     T L  A  G   + V LLL  G+        + + L  AA  G  +
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVN 1169

Query: 273  VSRVLIHAGGCAN--VVDHQGASPLHLAVRHNFPALVRLLINSDSDVNA-VDNRQQTPLH 329
            + ++L++AG   N       G SPL LA  +     V+LL++  SD+NA ++  + T L 
Sbjct: 1170 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALT 1229

Query: 330  LAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSL 372
            LA      ++  +LL    ++  R K G T L  A    +  +
Sbjct: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 36/126 (28%), Positives = 56/126 (44%), Gaps = 10/126 (7%)

Query: 28   VGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEAR 87
            VGR+    G  VN          AL  AA  GH +   LL+   A +D           R
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHID----------VR 1321

Query: 88   LCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDL 147
               G   L L++  GH  ++Q+LV +GA +       +T L  A +KGHV V+ ++++++
Sbjct: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381

Query: 148  EDVALD 153
                 D
Sbjct: 1382 NQFPSD 1387



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 17/63 (26%), Positives = 35/63 (55%), Gaps = 1/63 (1%)

Query: 316  DVNA-VDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVD 374
            D++A  ++   T L LA     +++  +L+     +  RDK+G T L +A  + HV +V+
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 375  MII 377
            +++
Sbjct: 1106 ILL 1108


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  136 bits (342), Expect = 5e-32
 Identities = 114/381 (29%), Positives = 173/381 (45%), Gaps = 49/381 (12%)

Query: 32  QELIGRRVNTRARNHVGRVA-LHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCF 90
           Q L+    N   R + G +  L  A+  G+   V+LLL H+A V+ + A G       C 
Sbjct: 255 QVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 314

Query: 91  GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDV 150
           G          G + I+++L+N GA I   +++G T L  AA  GHV V   +++    +
Sbjct: 315 G----------GFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364

Query: 151 ALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALH------------- 197
              H ++   +A   A   G LD + FL+ +G D   K  E +TAL              
Sbjct: 365 NT-HSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423

Query: 198 --------------------LAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSH 237
                               LAA  GH+ +   L++ G +LEE N EG T L  AA   H
Sbjct: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 483

Query: 238 PDCVQLLLRAGSTVNALTQKNL-SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLH 296
            + V LLL  G+ +NA T++   + L  A   G  +V+  LI AG     ++   ++PL 
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLM 540

Query: 297 LAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQ 356
            A +     LV+ L+ S ++V+A      T L  A E+   D+AD+LL AG DL    + 
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600

Query: 357 GKTALAVAVRSNHVSLVDMII 377
           G+T L  A R+ H+  V  +I
Sbjct: 601 GRTPLMKAARAGHLCTVQFLI 621



 Score =  123 bits (308), Expect = 5e-28
 Identities = 104/365 (28%), Positives = 174/365 (47%), Gaps = 20/365 (5%)

Query: 17  RQLHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           R L EA    +V  +++L+  GR VN       G   L  A  AG+ +  ++LL   A V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEE--GESLLCLACSAGYYELAQVLLAMHANV 264

Query: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
           ++    G +T          L+ ++  G+L I+++L+   A ++ +S  G T L  A   
Sbjct: 265 EDRGNKGDITP---------LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAG 315

Query: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE-GN 193
           G V ++  ++ +  ++  DH +  G T    AA  G ++    L+  G   N    E   
Sbjct: 316 GFVDIVKVLLNEGANIE-DHNEN-GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 373

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           +AL LA  +GH+ +++ L++ G D E +  E  TAL  A    H +  +LLL +G+ VN 
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
                 S L  AA  G  +++ +LI  G     V+ +G +PL  A R     +V LL+  
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493

Query: 314 DSDVNA-VDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSL 372
            +++NA  +  Q+T L LA    + ++AD L+ AG D+ L      T L  A +  H+ L
Sbjct: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLEL 550

Query: 373 VDMII 377
           V  ++
Sbjct: 551 VKYLL 555



 Score =  123 bits (308), Expect = 5e-28
 Identities = 106/370 (28%), Positives = 166/370 (44%), Gaps = 31/370 (8%)

Query: 34  LIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD------EEDAV------- 80
           L+    N    N  G   L  AA AGH +  R+LL+H A ++      +E A+       
Sbjct: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 81  -----------GALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLH 129
                      GA  E +      AL+ +   GH+ + ++L++SGA+++  +    + L 
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 130 CAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKD 189
            AA  GHV + A ++E      L+ V+  G T    AA  G  + +  L+  G + N + 
Sbjct: 444 LAACGGHVELAALLIE--RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501

Query: 190 KEGN-TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG 248
           +E   TAL LA   G   V   L+  G D+E   +   T L  A+   H + V+ LL +G
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 558

Query: 249 STVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVR 308
           + V+A T    + L YA  +G  DV+ VL+ AG         G +PL  A R      V+
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618

Query: 309 LLINSDSDVN-AVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRS 367
            LI+  ++VN A  N   T + LA       + ++LL  G D   R K G T L  A + 
Sbjct: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678

Query: 368 NHVSLVDMII 377
            H ++V  ++
Sbjct: 679 GHTNVVSYLL 688



 Score =  111 bits (278), Expect = 1e-24
 Identities = 79/291 (27%), Positives = 142/291 (48%), Gaps = 6/291 (2%)

Query: 94   ALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALD 153
            AL L+   GH  ++ +L+   AKI    K G T L  AA  GHV V+  +++   D+   
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117

Query: 154  HVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD 213
              ++   T    A   G+ + +D L+  G +   ++    T L LAA  G++ +++ L++
Sbjct: 1118 S-ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 214  IGLDLEEQNAE--GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLS-CLHYAALSGS 270
             G ++  +     G++ L  AA   H   V+LLL  GS +NA  + N +  L  A   G 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 271  EDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNA--VDNRQQTPL 328
             +V  +L+            G +PL  A    +  + R+L++  +DVNA  V + + T L
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 329  HLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
             +AA+       ++L+  G  +++R+K+G T L +A    H  +V ++++A
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA 1347



 Score =  109 bits (272), Expect = 7e-24
 Identities = 94/336 (27%), Positives = 152/336 (45%), Gaps = 22/336 (6%)

Query: 51   ALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQIL 110
            AL  A   GHE+ V +L+  +A ++  D  G             L+L+A  GH+ +++IL
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKG----------FTPLILAATAGHVGVVEIL 1107

Query: 111  VNSGAKIHCES---KDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAA 167
            ++ G  I  +S   KD  T L  A   G   V+  ++        +H +    T    AA
Sbjct: 1108 LDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLA--RGANKEHRNVSDYTPLSLAA 1163

Query: 168  EHGQLDALDFLVGSGCDHNVK--DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQ-NAE 224
              G ++ +  L+ +G + N +   K G + L LAA  GH+  ++ L+D+G D+  Q    
Sbjct: 1164 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETN 1223

Query: 225  GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284
              TAL  A      + V LLL   + V    +  L+ L  AA  G  +V RVL+  G   
Sbjct: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 285  NV--VDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADM 342
            N   V     + L +A          LLI+  + ++  + +  TPL LA+     D+  +
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 343  LLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
            L+ AG D++  D +  T L  A R  HV +V  ++K
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 88/287 (30%), Positives = 128/287 (44%), Gaps = 27/287 (9%)

Query: 16  ERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75
           E  L  AA   +V     LI R  N    N  G   L  AA  GHE+ V LLL   A ++
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498

Query: 76  ---EEDAVGALTEARLCFGMNA-------------------LLLSAWFGHLRILQILVNS 113
              EE    ALT A  C G +                    L+ ++  GHL +++ L+ S
Sbjct: 499 AQTEETQETALTLA-CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAS 557

Query: 114 GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLD 173
           GA +H  +  G T L  A + GH  V   +++   D  L+H  + GRT   +AA  G L 
Sbjct: 558 GANVHATTATGDTALTYACENGHTDVADVLLQAGAD--LEHESEGGRTPLMKAARAGHLC 615

Query: 174 ALDFLVGSGCDHN-VKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSA 232
            + FL+  G + N       +T + LA   GH+AV++ L+  G D   +  +G T L  A
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 675

Query: 233 AGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
           A G H + V  LL   + V ++   ++S L   +   S+ V RV  H
Sbjct: 676 AKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQ-VPRVPTH 721



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 70/248 (28%), Positives = 122/248 (49%), Gaps = 13/248 (5%)

Query: 34   LIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMN 93
            L+ R  N   RN      L  AA  G+   +++LL   A ++        T ++L  G++
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR------TGSKL--GIS 1192

Query: 94   ALLLSAWFGHLRILQILVNSGAKIHCESKDGL-TLLHCAAQKGHVPVLAFIMEDLEDVAL 152
             L+L+A  GH+  +++L++ G+ I+ + +    T L  A  +G   V++ +++   +V  
Sbjct: 1193 PLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANV-- 1250

Query: 153  DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKD--KEGNTALHLAAGRGHMAVLQR 210
            +H  K G T    AA  G  +    L+  G D N        +TAL +AA +GH    + 
Sbjct: 1251 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1310

Query: 211  LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 270
            L+  G  ++ +N +G T L  A+ G H D VQLL++AG+ V+A   + ++ L  A   G 
Sbjct: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGH 1370

Query: 271  EDVSRVLI 278
              V + L+
Sbjct: 1371 VKVVQYLV 1378



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 69/231 (29%), Positives = 110/231 (47%), Gaps = 13/231 (5%)

Query: 36   GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNAL 95
            G  +N+R  + +G   L  AA  GH  AV+LLL+  + ++ +      T         AL
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT---------AL 1228

Query: 96   LLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHV 155
             L+ + G   ++ +L++  A +   +K GLT L  AA  G+  V   +++   DV    V
Sbjct: 1229 TLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1288

Query: 156  DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 215
                 TA   AA+ G     + L+  G   +V++K+GNT L LA+  GH  V+Q LV  G
Sbjct: 1289 PSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 1348

Query: 216  LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAA 266
             D++  +   +T L SA    H   VQ L++    VN     ++ C+ Y A
Sbjct: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVNQF-PSDIECMRYIA 1395



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 99/348 (28%), Positives = 144/348 (41%), Gaps = 80/348 (22%)

Query: 19  LHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDE 76
           L EAA   +V   + L+  G  +NT + N     AL  A   GH   VR LLE  A  D+
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHLDMVRFLLE--AGADQ 398

Query: 77  EDAV-------------GALTEARLCFGMNA------------LLLSAWFGHLRILQILV 111
           E                G +  ARL     A            L L+A  GH+ +  +L+
Sbjct: 399 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 458

Query: 112 NSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIM----------EDLEDVAL--------- 152
             GA +   + +G T L  AA++GH  ++A ++          E+ ++ AL         
Sbjct: 459 ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFS 518

Query: 153 ---DHVDKLGR-------TAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGR 202
              D + K G        T    A++ G L+ + +L+ SG + +     G+TAL  A   
Sbjct: 519 EVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578

Query: 203 GHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN---- 258
           GH  V   L+  G DLE ++  G T L  AA   H   VQ L+  G+ VN  T  N    
Sbjct: 579 GHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTV 638

Query: 259 --LSCL--HYAALS-----GSE------DVSRVLIHA--GGCANVVDH 289
             L+C   H A +      G++      D S +LI A  GG  NVV +
Sbjct: 639 VSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSY 686



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 65/223 (29%), Positives = 102/223 (45%), Gaps = 4/223 (1%)

Query: 154  HVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD 213
            H +    TA   A   G  + +  L+        +DK+G T L LAA  GH+ V++ L+D
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109

Query: 214  IGLDLEEQNAEGL-TALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSED 272
             G D+E Q+     T L  A  G   + V LLL  G+        + + L  AA  G  +
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVN 1169

Query: 273  VSRVLIHAGGCAN--VVDHQGASPLHLAVRHNFPALVRLLINSDSDVNA-VDNRQQTPLH 329
            + ++L++AG   N       G SPL LA  +     V+LL++  SD+NA ++  + T L 
Sbjct: 1170 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALT 1229

Query: 330  LAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSL 372
            LA      ++  +LL    ++  R K G T L  A    +  +
Sbjct: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 36/126 (28%), Positives = 56/126 (44%), Gaps = 10/126 (7%)

Query: 28   VGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEAR 87
            VGR+    G  VN          AL  AA  GH +   LL+   A +D           R
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHID----------VR 1321

Query: 88   LCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDL 147
               G   L L++  GH  ++Q+LV +GA +       +T L  A +KGHV V+ ++++++
Sbjct: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381

Query: 148  EDVALD 153
                 D
Sbjct: 1382 NQFPSD 1387



 Score = 34.7 bits (78), Expect = 0.22
 Identities = 17/63 (26%), Positives = 35/63 (55%), Gaps = 1/63 (1%)

Query: 316  DVNA-VDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVD 374
            D++A  ++   T L LA     +++  +L+     +  RDK+G T L +A  + HV +V+
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 375  MII 377
            +++
Sbjct: 1106 ILL 1108


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score =  134 bits (338), Expect = 2e-31
 Identities = 97/341 (28%), Positives = 165/341 (48%), Gaps = 51/341 (14%)

Query: 74  VDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQ 133
           + ++DAV AL+E         LL++A+ G    +  L+N GA++                
Sbjct: 1   MSQQDAVAALSER--------LLVAAYKGQTENVVQLINKGARVA--------------- 37

Query: 134 KGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN 193
                                V K GRT  H AA  G L  +  L+ +GCD +V+D    
Sbjct: 38  ---------------------VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQ 76

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           TALH A   G+  ++  L+  G  L+ Q+ +G TALH A+        +LL++AG+ V A
Sbjct: 77  TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLA 136

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
             +   + LH A  +     +RVL+ AG  A++ ++ G + LH+A R+N  +++RLL+ +
Sbjct: 137 KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA 196

Query: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
              V+  +    T LH+AA    + +A +LL AG D  + +  G+T L  A   N+  + 
Sbjct: 197 FCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVA 256

Query: 374 DMIIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSV 414
            ++ KA +  R+ +       G+SL  K++  +E ++ +SV
Sbjct: 257 LLLTKAPQVLRFSR-------GRSLRKKRERLKEERRAQSV 290



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 72/263 (27%), Positives = 114/263 (43%), Gaps = 26/263 (9%)

Query: 8   ETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLL 67
           + D +  L  +L  AA +     + +LI +        H GR  LH AA  GH   V++L
Sbjct: 3   QQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKH-GRTPLHLAANKGHLPVVQIL 61

Query: 68  LEHEAAVDEED-----------------AVGALTEARLCF------GMNALLLSAWFGHL 104
           L+    +D +D                  + AL             G  AL  ++W G  
Sbjct: 62  LKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFS 121

Query: 105 RILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH 164
           +  ++LV +GA +  ++K G T LH A Q  H      ++  L     D  +  G T  H
Sbjct: 122 QSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLL--LAGSRADLKNNAGDTCLH 179

Query: 165 RAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE 224
            AA +  L  +  L+ + C  + K++ G+TALH+AA   H  V + L++ G D    N  
Sbjct: 180 VAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNA 239

Query: 225 GLTALHSAAGGSHPDCVQLLLRA 247
           G T L +A   ++P+   LL +A
Sbjct: 240 GQTPLETARYHNNPEVALLLTKA 262


>gi|30348954 mindbomb homolog 1 [Homo sapiens]
          Length = 1006

 Score =  132 bits (333), Expect = 6e-31
 Identities = 87/254 (34%), Positives = 132/254 (51%), Gaps = 10/254 (3%)

Query: 124 GLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGC 183
           G T +  A+Q GHV +L  +++   DV  +  DK G  A H AA   +   ++ L     
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAE--DKDGDRAVHHAAFGDEGAVIEVLHRGSA 521

Query: 184 DHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQL 243
           D N ++K   T LH+A  +GH+ V++ L+D G     Q++EG T LH A      D + +
Sbjct: 522 DLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAV 581

Query: 244 LLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQ---GASPLHLAVR 300
           LL AG+ V        + LH+AAL G+    RVL+       +VD +   G + LHLA  
Sbjct: 582 LLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAAL 641

Query: 301 HNFPALVRLLI---NSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQG 357
           +N   +  LL+   N++ D+  V+  QQT LHLA E     I  +L+ AG  L+++DK G
Sbjct: 642 NNHVEVAELLVHQGNANLDIQNVN--QQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDG 699

Query: 358 KTALAVAVRSNHVS 371
            T L  A+R + +S
Sbjct: 700 DTPLHEALRHHTLS 713



 Score =  114 bits (286), Expect = 2e-25
 Identities = 101/368 (27%), Positives = 167/368 (45%), Gaps = 26/368 (7%)

Query: 7   WETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRL 66
           +ET     L  +L +AA   +V ++++L+ R          G  A+  A+  GH   ++L
Sbjct: 423 FETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKL 482

Query: 67  LLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLT 126
           LL+    V+ ED  G        FG              ++++L    A ++  +K   T
Sbjct: 483 LLKQNVDVEAEDKDGDRAVHHAAFGDEGA----------VIEVLHRGSADLNARNKRRQT 532

Query: 127 LLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHN 186
            LH A  KGH+ V+  +++     +L   D  G T  H A    + D L  L+ +G D  
Sbjct: 533 PLHIAVNKGHLQVVKTLLDFGCHPSLQ--DSEGDTPLHDAISKKRDDILAVLLEAGADVT 590

Query: 187 VKDKEGNTALHLAAGRGH---MAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQL 243
           + +  G  ALH AA RG+   M VL   +     ++E+  +G TALH AA  +H +  +L
Sbjct: 591 ITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAEL 650

Query: 244 LLRAGSTVNALTQKNL-SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHN 302
           L+  G+    +   N  + LH A       + R+L+ AG   ++ D  G +PLH A+RH+
Sbjct: 651 LVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHH 710

Query: 303 FPALVRLLINSDSDVNAVDNRQQTPLHL---------AAEHAWQDIADMLLIAGVDLNLR 353
             + +R L     DV  VD   +   +          A + +   IA  L   G DL++R
Sbjct: 711 TLSQLRQL-QDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIR 769

Query: 354 DKQGKTAL 361
           +K+G++ L
Sbjct: 770 NKKGQSPL 777



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 52/189 (27%), Positives = 98/189 (51%), Gaps = 3/189 (1%)

Query: 192 GNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTV 251
           G+TA+  A+  GH+ +L+ L+   +D+E ++ +G  A+H AA G     +++L R  + +
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523

Query: 252 NALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLI 311
           NA  ++  + LH A   G   V + L+  G   ++ D +G +PLH A+      ++ +L+
Sbjct: 524 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL 583

Query: 312 NSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQ---GKTALAVAVRSN 368
            + +DV   +N     LH AA         +LL       + D++   G TAL +A  +N
Sbjct: 584 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN 643

Query: 369 HVSLVDMII 377
           HV + ++++
Sbjct: 644 HVEVAELLV 652



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 59/202 (29%), Positives = 93/202 (46%), Gaps = 5/202 (2%)

Query: 193 NTALHLAAGRGHMAVLQRLVDI-GLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTV 251
           N  L  AA  G +A ++ L+    +D+  Q A G TA+ +A+   H D ++LLL+    V
Sbjct: 432 NEELVKAAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQNVDV 490

Query: 252 NALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLI 311
            A  +     +H+AA      V  VL       N  + +  +PLH+AV      +V+ L+
Sbjct: 491 EAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLL 550

Query: 312 NSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTAL-AVAVRSNHV 370
           +     +  D+   TPLH A      DI  +LL AG D+ + +  G  AL   A+R N  
Sbjct: 551 DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610

Query: 371 SLVDMIIKADRFYRWEKDHPSD 392
           ++  ++ K  R   W  D   D
Sbjct: 611 AMRVLLSKLPR--PWIVDEKKD 630



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 50/190 (26%), Positives = 82/190 (43%), Gaps = 20/190 (10%)

Query: 19  LHEAARQNNVGRMQELIGRRVN---TRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75
           LH AA + N   M+ L+ +         +   G  ALH AA   H +   LL+    A  
Sbjct: 600 LHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANL 659

Query: 76  EEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKG 135
           +   V   T         AL L+    H +I+++LV +GAK+  + KDG T LH  A + 
Sbjct: 660 DIQNVNQQT---------ALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLH-EALRH 709

Query: 136 HVPVLAFIMEDLEDVA-LDHVDKLGRTAF------HRAAEHGQLDALDFLVGSGCDHNVK 188
           H       ++D++DV  +D   +  +           A +        FL  +G D +++
Sbjct: 710 HTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIR 769

Query: 189 DKEGNTALHL 198
           +K+G + L L
Sbjct: 770 NKKGQSPLDL 779


>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
           isoform 1 [Homo sapiens]
          Length = 1298

 Score =  127 bits (318), Expect = 3e-29
 Identities = 85/249 (34%), Positives = 132/249 (53%), Gaps = 5/249 (2%)

Query: 87  RLCFGMNALLLSAWFGHLRILQILVNSGA--KIHCESKDGLTLLHCAAQKGHVPVLAFIM 144
           +L F    L  SA  G L+ + +++  G       E ++  + LH AA+ GHV +   ++
Sbjct: 734 KLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV 793

Query: 145 EDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGH 204
           +      +D   +  RT    AAE+  L+A+ +L+ +G   + KD EG+T LHLAA +GH
Sbjct: 794 Q--AGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGH 851

Query: 205 MAVLQRLVDIG-LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLH 263
             V+Q L+  G +D+  Q+  G T +  A    H D V+LLL  GS +N    +   CLH
Sbjct: 852 YEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLH 911

Query: 264 YAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNR 323
           +AA SG  D++ +L+ A    + V+  G SPLH+A R N    V L ++ DSDV   +  
Sbjct: 912 WAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKE 971

Query: 324 QQTPLHLAA 332
            +TPL  A+
Sbjct: 972 GETPLQCAS 980



 Score =  107 bits (266), Expect = 3e-23
 Identities = 75/239 (31%), Positives = 120/239 (50%), Gaps = 9/239 (3%)

Query: 150 VALDHVDKLGRTAFHR-----AAEHGQLDALDFLVGSGCDHNVKDKEGN--TALHLAAGR 202
           +ALD  +K  +  FH      +A  G+L  +  ++  G D N K +  N  + LH AA  
Sbjct: 725 IALDS-EKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEA 783

Query: 203 GHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCL 262
           GH+ +   LV  G +++  + +  T L  AA  +H + V+ L++AG+ V+    +  +CL
Sbjct: 784 GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCL 843

Query: 263 HYAALSGSEDVSRVLIHAGGC-ANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVD 321
           H AA  G  +V + L+  G    N  D  G +P+  A  +    LV+LL++  SD+N  D
Sbjct: 844 HLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 903

Query: 322 NRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKAD 380
           N +   LH AA     DIA++LL A  DL+  +  G + L +A R N    V + +  D
Sbjct: 904 NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRD 962



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 76/256 (29%), Positives = 124/256 (48%), Gaps = 17/256 (6%)

Query: 17  RQLHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           +QL+ +ARQ  + ++  ++  G   N +  +   R  LH AA AGH     +L++  A +
Sbjct: 740 KQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799

Query: 75  D--EEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAA 132
           D   ED    L EA            A   HL  ++ L+ +GA +  +  +G T LH AA
Sbjct: 800 DTCSEDQRTPLMEA------------AENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAA 847

Query: 133 QKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEG 192
           +KGH  V+ +++ + + + ++  D  G T    A E+  +D +  L+  G D N++D E 
Sbjct: 848 KKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEE 906

Query: 193 NTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVN 252
           N  LH AA  G + + + L+    DL   N  G + LH AA  +  DCV L L   S V 
Sbjct: 907 NICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVT 966

Query: 253 ALTQKNLSCLHYAALS 268
              ++  + L  A+L+
Sbjct: 967 LKNKEGETPLQCASLN 982



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 36/170 (21%), Positives = 71/170 (41%), Gaps = 13/170 (7%)

Query: 22   AARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVG 81
            A    +V  ++ L+ +  +   R++   + LHWAA +G      +LL   AA  +  AV 
Sbjct: 880  ATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILL---AAKCDLHAVN 936

Query: 82   ALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLA 141
                     G + L ++A       + + ++  + +  ++K+G T L CA+    V    
Sbjct: 937  I-------HGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSAL 989

Query: 142  FIMEDLEDVALDH---VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVK 188
             + + L+D A D    V+++      R  E   +  ++ +    C  N K
Sbjct: 990  QMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYK 1039


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  123 bits (308), Expect = 5e-28
 Identities = 104/365 (28%), Positives = 174/365 (47%), Gaps = 20/365 (5%)

Query: 17  RQLHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
           R L EA    +V  +++L+  GR VN       G   L  A  AG+ +  ++LL   A V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEE--GESLLCLACSAGYYELAQVLLAMHANV 264

Query: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134
           ++    G +T          L+ ++  G+L I+++L+   A ++ +S  G T L  A   
Sbjct: 265 EDRGNKGDITP---------LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAG 315

Query: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE-GN 193
           G V ++  ++ +  ++  DH +  G T    AA  G ++    L+  G   N    E   
Sbjct: 316 GFVDIVKVLLNEGANIE-DHNEN-GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 373

Query: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
           +AL LA  +GH+ +++ L++ G D E +  E  TAL  A    H +  +LLL +G+ VN 
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433

Query: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
                 S L  AA  G  +++ +LI  G     V+ +G +PL  A R     +V LL+  
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493

Query: 314 DSDVNA-VDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSL 372
            +++NA  +  Q+T L LA    + ++AD L+ AG D+ L      T L  A +  H+ L
Sbjct: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLEL 550

Query: 373 VDMII 377
           V  ++
Sbjct: 551 VKYLL 555



 Score =  123 bits (308), Expect = 5e-28
 Identities = 106/358 (29%), Positives = 163/358 (45%), Gaps = 49/358 (13%)

Query: 32  QELIGRRVNTRARNHVGRVA-LHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCF 90
           Q L+    N   R + G +  L  A+  G+   V+LLL H+A V+ + A G       C 
Sbjct: 255 QVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 314

Query: 91  GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDV 150
           G          G + I+++L+N GA I   +++G T L  AA  GHV V   +++    +
Sbjct: 315 G----------GFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364

Query: 151 ALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALH------------- 197
              H ++   +A   A   G LD + FL+ +G D   K  E +TAL              
Sbjct: 365 NT-HSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423

Query: 198 --------------------LAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSH 237
                               LAA  GH+ +   L++ G +LEE N EG T L  AA   H
Sbjct: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 483

Query: 238 PDCVQLLLRAGSTVNALTQKNL-SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLH 296
            + V LLL  G+ +NA T++   + L  A   G  +V+  LI AG     ++   ++PL 
Sbjct: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLM 540

Query: 297 LAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRD 354
            A +     LV+ L+ S ++V+A      T L  A E+   D+AD+LL AG DL+ ++
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 70/259 (27%), Positives = 107/259 (41%), Gaps = 59/259 (22%)

Query: 19  LHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDE 76
           L EAA   +V   + L+  G  +NT + N     AL  A   GH   VR LLE  A  D+
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHLDMVRFLLE--AGADQ 398

Query: 77  EDAV-------------GALTEARLCFGMNA------------LLLSAWFGHLRILQILV 111
           E                G +  ARL     A            L L+A  GH+ +  +L+
Sbjct: 399 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 458

Query: 112 NSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIM----------EDLEDVAL--------- 152
             GA +   + +G T L  AA++GH  ++A ++          E+ ++ AL         
Sbjct: 459 ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFS 518

Query: 153 ---DHVDKLGR-------TAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGR 202
              D + K G        T    A++ G L+ + +L+ SG + +     G+TAL  A   
Sbjct: 519 EVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578

Query: 203 GHMAVLQRLVDIGLDLEEQ 221
           GH  V   L+  G DL++Q
Sbjct: 579 GHTDVADVLLQAGADLDKQ 597



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 49/169 (28%), Positives = 70/169 (41%), Gaps = 14/169 (8%)

Query: 16  ERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75
           E  L  AA   +V     LI R  N    N  G   L  AA  GHE+ V LLL   A ++
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498

Query: 76  EEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKG 135
            +      T         AL L+   G   +   L+ +GA I        T L  A+Q+G
Sbjct: 499 AQTEETQET---------ALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEG 546

Query: 136 HVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCD 184
           H+ ++ +++    +V        G TA   A E+G  D  D L+ +G D
Sbjct: 547 HLELVKYLLASGANV--HATTATGDTALTYACENGHTDVADVLLQAGAD 593


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.133    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,297,171
Number of Sequences: 37866
Number of extensions: 800218
Number of successful extensions: 8372
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 369
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 2011
Number of HSP's gapped (non-prelim): 2492
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.