Search of human proteins with 94981556

Search of human proteins with 94981556

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|94981556 transglutaminase 5 isoform 1 [Homo sapiens]
         (720 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|94981556 transglutaminase 5 isoform 1 [Homo sapiens]              1476   0.0  
gi|4759230 transglutaminase 5 isoform 2 [Homo sapiens]               1181   0.0  
gi|16445035 transglutaminase 7 [Homo sapiens]                         664   0.0  
gi|148664232 transglutaminase 6 [Homo sapiens]                        623   e-178
gi|189458821 transglutaminase 3 precursor [Homo sapiens]              605   e-173
gi|39777597 transglutaminase 2 isoform a [Homo sapiens]               541   e-154
gi|39777599 transglutaminase 2 isoform b [Homo sapiens]               481   e-135
gi|4507475 transglutaminase 1 [Homo sapiens]                          446   e-125
gi|119395709 coagulation factor XIII A1 subunit precursor [Homo ...   404   e-112
gi|156627577 transglutaminase 4 (prostate) [Homo sapiens]             386   e-107
gi|166362737 erythrocyte membrane protein band 4.2 isoform 2 [Ho...   383   e-106
gi|166362735 erythrocyte membrane protein band 4.2 isoform 1 [Ho...   379   e-105
gi|154090979 hypothetical protein LOC57481 [Homo sapiens]              33   1.2  
gi|4507773 ubiquitin-conjugating enzyme E2D 1 [Homo sapiens]           32   2.7  
gi|5453952 beta isoform of regulatory subunit B56, protein phosp...    31   3.5  
gi|31541941 heat shock 70kDa protein 4-like [Homo sapiens]             31   4.6  
gi|151101459 SAPS domain family, member 1 [Homo sapiens]               31   4.6  
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]               30   6.0  
gi|22209009 protein kinase CHK2 isoform b [Homo sapiens]               30   6.0  
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]                30   6.0  

>gi|94981556 transglutaminase 5 isoform 1 [Homo sapiens]
          Length = 720

 Score = 1476 bits (3820), Expect = 0.0
 Identities = 720/720 (100%), Positives = 720/720 (100%)

Query: 1   MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60
           MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV
Sbjct: 1   MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60

Query: 61  VETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIH 120
           VETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIH
Sbjct: 61  VETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIH 120

Query: 121 IDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCP 180
           IDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCP
Sbjct: 121 IDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCP 180

Query: 181 WNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNG 240
           WNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNG
Sbjct: 181 WNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNG 240

Query: 241 NWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVIT 300
           NWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVIT
Sbjct: 241 NWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVIT 300

Query: 301 NFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLD 360
           NFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLD
Sbjct: 301 NFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLD 360

Query: 361 ATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDT 420
           ATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDT
Sbjct: 361 ATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDT 420

Query: 421 SSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQP 480
           SSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQP
Sbjct: 421 SSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQP 480

Query: 481 SRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLK 540
           SRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLK
Sbjct: 481 SRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLK 540

Query: 541 VNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALG 600
           VNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALG
Sbjct: 541 VNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALG 600

Query: 601 EEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGS 660
           EEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGS
Sbjct: 601 EEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGS 660

Query: 661 GLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL 720
           GLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL
Sbjct: 661 GLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL 720


>gi|4759230 transglutaminase 5 isoform 2 [Homo sapiens]
          Length = 638

 Score = 1181 bits (3056), Expect = 0.0
 Identities = 575/575 (100%), Positives = 575/575 (100%)

Query: 146 EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ 205
           EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ
Sbjct: 64  EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ 123

Query: 206 TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW 265
           TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW
Sbjct: 124 TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW 183

Query: 266 NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL 325
           NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL
Sbjct: 184 NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL 243

Query: 326 GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE 385
           GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE
Sbjct: 244 GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE 303

Query: 386 VDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYK 445
           VDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYK
Sbjct: 304 VDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYK 363

Query: 446 YEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVV 505
           YEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVV
Sbjct: 364 YEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDVV 423

Query: 506 QVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFI 565
           QVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFI
Sbjct: 424 QVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGSPLSPFWQDTAFI 483

Query: 566 TLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITIN 625
           TLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITIN
Sbjct: 484 TLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYPSITIN 543

Query: 626 VLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIILE 685
           VLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIILE
Sbjct: 544 VLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIILE 603

Query: 686 TVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL 720
           TVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL
Sbjct: 604 TVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL 638



 Score =  127 bits (320), Expect = 3e-29
 Identities = 63/63 (100%), Positives = 63/63 (100%)

Query: 1  MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60
          MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV
Sbjct: 1  MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60

Query: 61 VET 63
          VET
Sbjct: 61 VET 63


>gi|16445035 transglutaminase 7 [Homo sapiens]
          Length = 710

 Score =  664 bits (1713), Expect = 0.0
 Identities = 354/721 (49%), Positives = 448/721 (62%), Gaps = 26/721 (3%)

Query: 5   LEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETG 64
           L +   DLQSSRNN  HHT+E+ V  L VRRGQ F L L F +R FQ   D+I FV ETG
Sbjct: 7   LRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSF-SRPFQSQNDHITFVAETG 65

Query: 65  PLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSF 124
           P P   LGTRA F L R    + W A   T  + S +VSL  P  A +G Y LKI I   
Sbjct: 66  PKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKIEISQG 125

Query: 125 QGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYG 184
           QG    Y LG FILLFNPW PED VYL SE   QEY+M DYGF+Y+G + +I   PWNYG
Sbjct: 126 QGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWNYG 185

Query: 185 QFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSE 244
           QFE+ IIDIC ++L+KSL+   +PA DC+ R   VYV RVV AMINSNDDNGVL GNW E
Sbjct: 186 QFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNWGE 245

Query: 245 NYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDS 304
           +Y+ G +P EW GSVAIL+QW+A G QPV+YGQCWVFA+VMCTVMRCLG+PTRV++NF S
Sbjct: 246 DYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFRS 305

Query: 305 GHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQ 364
            H+ D NL ID YYD    +L  +K+D IWNFHVWNECWM RKDLPP Y GWQVLD TPQ
Sbjct: 306 AHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTPQ 365

Query: 365 EMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQK-LHQDTSSV 423
           + S+G++CCGPASV+AI+EG+V L YDTPFV++ VNAD + WL+  G+ Q+ L  +TSS+
Sbjct: 366 QTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHNTSSI 425

Query: 424 GNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRP 483
           G  ISTK + SD+R  IT +YKY EGS +ER VF+KA +K+             L P R 
Sbjct: 426 GKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKM-------------LGPQRA 472

Query: 484 TSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFK-----D 538
           +    D    L +  LR        L+  L   P  GQD+  +L    +           
Sbjct: 473 SLPFLD---LLESGGLRDQ---PAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIG 526

Query: 539 LKVNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISA 598
           L V   AQ+LLH G    PFW+ T  + L   +   +P  + YS Y   L+ +KLIR+S 
Sbjct: 527 LVVRFCAQALLHGGGTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSG 586

Query: 599 LGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVE 658
           + E + +   +LV K I L  P ++I V   A V + L + V  +N L   +  C + +E
Sbjct: 587 IAEVEETGRSMLVLKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLE 646

Query: 659 GSGLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDF 718
           GSGL   Q    LG L   H   I L+  P K+G RQ+Q  + SN+ K+IKGY++++V  
Sbjct: 647 GSGLINGQIAKDLGTLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTV 706

Query: 719 A 719
           A
Sbjct: 707 A 707


>gi|148664232 transglutaminase 6 [Homo sapiens]
          Length = 706

 Score =  623 bits (1607), Expect = e-178
 Identities = 331/714 (46%), Positives = 467/714 (65%), Gaps = 15/714 (2%)

Query: 4   GLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVET 63
           G+ V   D Q SRN   HHT+E     L+VRRGQ+F+LTL   +R+     + +IF +ET
Sbjct: 3   GIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLEL-SRALDCE-EILIFTMET 60

Query: 64  GPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDS 123
           GP    AL T+AVF  +       W A  E     +  VSL +PP+A +GRYLL I + S
Sbjct: 61  GPRASEALHTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSIRLSS 120

Query: 124 FQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNY 183
            +      +LGEF+LLFNPWC ED V+L SE +RQEYV++D G I++G +  IR   WNY
Sbjct: 121 HRKHSNR-RLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNY 179

Query: 184 GQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWS 243
           GQFE+ I++ICL +LD+S   Q +PATD + R +P+YV+RV+ AM+NSN+D GV+ G W 
Sbjct: 180 GQFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQ 239

Query: 244 ENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFD 303
             Y  G +P  W GSVAIL++W     +PV+YGQCWVFA V+CTV+RCLGI TRV++NF+
Sbjct: 240 GKYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNFN 299

Query: 304 SGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATP 363
           S HDTD NL +D+Y D+ GR L +  +D++WNFHVWNE W AR+DL P+Y GWQVLDATP
Sbjct: 300 SAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATP 359

Query: 364 QEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWL-VQGGKEQKLHQDTSS 422
           QE S GV+ CGPASV AI+EG+V L +D PFVF+ VNAD ++WL  +    ++++ +T  
Sbjct: 360 QEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKK 419

Query: 423 VGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSR 482
           +G  ISTK++ SD R DIT+ YKY EGS +ERQV+ KA+ +L       S R   ++ + 
Sbjct: 420 IGRCISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRL--FGVEASGRRIWIRRAG 477

Query: 483 PTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVN 542
              L +D    L  P+ +PS    ++ KFK+L+PP +G D+   L   N++S+ + ++VN
Sbjct: 478 GRCLWRD---DLLEPATKPS----IAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVN 530

Query: 543 LSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEE 602
           LS  ++L+   P++    ++  + L P+E K  P  ISYS+Y + L+ DK I ++A+   
Sbjct: 531 LSGATILYTRKPVAEILHESHAVRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMC-L 589

Query: 603 KSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGL 662
            +  EK+LV K ITL    ITI VLG A+V   ++++V   NPL E+V+DC L VEGSGL
Sbjct: 590 VTKGEKLLVEKDITLE-DFITIKVLGPAMVGVAVTVEVTVVNPLIERVKDCALMVEGSGL 648

Query: 663 FKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 716
            ++Q  + +  L+PQ +AS+  +  P KSG RQ+Q ++ S  F DIKG+  V+V
Sbjct: 649 LQEQLSIDVPTLEPQERASVQFDITPSKSGPRQLQVDLVSPHFPDIKGFVIVHV 702


>gi|189458821 transglutaminase 3 precursor [Homo sapiens]
          Length = 693

 Score =  605 bits (1560), Expect = e-173
 Identities = 318/714 (44%), Positives = 451/714 (63%), Gaps = 28/714 (3%)

Query: 5   LEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETG 64
           L V   + Q++ N   HHT++ +   L++RRGQ F + L   N+      + + F+V TG
Sbjct: 4   LGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQV-LMIMNKGLGSN-ERLEFIVSTG 61

Query: 65  PLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSF 124
           P P  +  T+AVF L+ + S   W A L+ +   +  +S+ +P +A +GRY + + I S 
Sbjct: 62  PYPSESAMTKAVFPLS-NGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFS- 119

Query: 125 QGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYG 184
           QG +++ +LG FILLFNPW   D+V++ +  +R+EYV  D G I+ GS N I    WN+G
Sbjct: 120 QGGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFG 179

Query: 185 QFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSE 244
           QFE+ I+ ICL +LD+SL+F+ D ATD A R  P YV RV+ AMINSNDDNGVL GNWS 
Sbjct: 180 QFEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSG 239

Query: 245 NYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDS 304
            YT G +P  W GSV ILK W  +G  PVRYGQCWVFA  + T +R LGIP+RVITNF+S
Sbjct: 240 TYTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNS 299

Query: 305 GHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQ 364
            HDTD NL +D YYD  G  L +K  D++WNFHVWNE W  R DL P+YGGWQVLDATPQ
Sbjct: 300 AHDTDRNLSVDVYYDPMGNPL-DKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQ 358

Query: 365 EMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQG--GKEQKLHQDTSS 422
           E S GV+ CGPASV  ++EG+V LN+D PF+F+ VNAD ++WL     GK+ K   ++ +
Sbjct: 359 ERSQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHT 418

Query: 423 VGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSR 482
           +G +ISTK++ S+ R D+T+ YKY EGS QERQVF KAL KLK                 
Sbjct: 419 IGRYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPN--------------- 463

Query: 483 PTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVN 542
            T  +  S   L T    PS    +  K K+     +G+++  VLL  N+S   K + VN
Sbjct: 464 -TPFAATSSMGLETEEQEPS----IIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVN 518

Query: 543 LSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEE 602
           ++A +++++G+ +   W+D+A ++L P+E   +P KISY+QY +YL +D +IRI+A+ + 
Sbjct: 519 MTAWTIIYNGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKV 578

Query: 603 KSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGL 662
               E ++V + I L  P++T+ VL  A V +P+++Q++FSNPL E V DCVL VEGSGL
Sbjct: 579 PDESE-VVVERDIILDNPTLTLEVLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGL 637

Query: 663 FKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 716
                K+ +  L P+  + +  + +P +SG +Q+ A+   NKF  IK   ++ V
Sbjct: 638 LLGNLKIDVPTLGPKEGSRVRFDILPSRSGTKQLLADFSCNKFPAIKAMLSIDV 691


>gi|39777597 transglutaminase 2 isoform a [Homo sapiens]
          Length = 687

 Score =  541 bits (1395), Expect = e-154
 Identities = 296/721 (41%), Positives = 405/721 (56%), Gaps = 42/721 (5%)

Query: 1   MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60
           MA+ L +   DL+   N   HHT ++  + L+VRRGQ F LTL+F  R+++  +D++ F 
Sbjct: 1   MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS 60

Query: 61  VETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIH 120
           V TGP P    GT+A F L        W A +      +  + L  P  A +G Y L + 
Sbjct: 61  VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE 120

Query: 121 IDS-FQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPC 179
             + +QGS  ++ LG FILLFN WCP DAVYLDSE +RQEYV+   GFIYQGS  +I+  
Sbjct: 121 ASTGYQGS--SFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNI 178

Query: 180 PWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLN 239
           PWN+GQFED I+DICL LLD +  F  +   DC+ R SPVYV RVV  M+N NDD GVL 
Sbjct: 179 PWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLL 238

Query: 240 GNWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVI 299
           G W  NY DG +P  W GSV IL++W   GCQ V+YGQCWVFAAV CTV+RCLGIPTRV+
Sbjct: 239 GRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVV 298

Query: 300 TNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVL 359
           TN++S HD + NL+I+ + +  G I G+ K + IWNFH W E WM R DL P Y GWQ L
Sbjct: 299 TNYNSAHDQNSNLLIEYFRNEFGEIQGD-KSEMIWNFHCWVESWMTRPDLQPGYEGWQAL 357

Query: 360 DATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQ-GGKEQKLHQ 418
           D TPQE S G YCCGP  VRAIKEG++   YD PFVF+ VNAD + W+ Q  G   K   
Sbjct: 358 DPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSIN 417

Query: 419 DTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAEL 478
            +  VG  ISTKS+  DER+DIT  YKY EGS +ER+ F                     
Sbjct: 418 RSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAF--------------------- 456

Query: 479 QPSRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKD 538
                        R+ H   L   +   ++++ ++    NMG D        N +++   
Sbjct: 457 ------------TRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYV 504

Query: 539 LKVNLSAQSLLHDGSPLSPFWQDTAFITLS--PKEAKTYPCKISYSQYSQYLSTDKLIRI 596
            ++ L A+++ ++G  L P       + L+  P   K+ P  I Y +Y   L+   LI++
Sbjct: 505 CRLLLCARTVSYNGI-LGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKV 563

Query: 597 SALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLT 656
            AL  E      +L  + + L  P I I +LG     + L  +V   NPL   +E C  T
Sbjct: 564 RALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFT 623

Query: 657 VEGSGLFKKQQKVFL-GVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVY 715
           VEG+GL ++Q+ V +   ++   +  + ++ +P   G  ++  N  S+K K +KG+RNV 
Sbjct: 624 VEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVI 683

Query: 716 V 716
           +
Sbjct: 684 I 684


>gi|39777599 transglutaminase 2 isoform b [Homo sapiens]
          Length = 548

 Score =  481 bits (1237), Expect = e-135
 Identities = 242/475 (50%), Positives = 303/475 (63%), Gaps = 7/475 (1%)

Query: 1   MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV 60
           MA+ L +   DL+   N   HHT ++  + L+VRRGQ F LTL+F  R+++  +D++ F 
Sbjct: 1   MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS 60

Query: 61  VETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIH 120
           V TGP P    GT+A F L        W A +      +  + L  P  A +G Y L + 
Sbjct: 61  VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE 120

Query: 121 IDS-FQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPC 179
             + +QGS  ++ LG FILLFN WCP DAVYLDSE +RQEYV+   GFIYQGS  +I+  
Sbjct: 121 ASTGYQGS--SFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNI 178

Query: 180 PWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLN 239
           PWN+GQFED I+DICL LLD +  F  +   DC+ R SPVYV RVV  M+N NDD GVL 
Sbjct: 179 PWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLL 238

Query: 240 GNWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVI 299
           G W  NY DG +P  W GSV IL++W   GCQ V+YGQCWVFAAV CTV+RCLGIPTRV+
Sbjct: 239 GRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVV 298

Query: 300 TNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVL 359
           TN++S HD + NL+I+ + +  G I G+ K + IWNFH W E WM R DL P Y GWQ L
Sbjct: 299 TNYNSAHDQNSNLLIEYFRNEFGEIQGD-KSEMIWNFHCWVESWMTRPDLQPGYEGWQAL 357

Query: 360 DATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQ-GGKEQKLHQ 418
           D TPQE S G YCCGP  VRAIKEG++   YD PFVF+ VNAD + W+ Q  G   K   
Sbjct: 358 DPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSIN 417

Query: 419 DTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKA--LQKLKARSFHG 471
            +  VG  ISTKS+  DER+DIT  YKY EGS +ER+ F +A  L KL  +   G
Sbjct: 418 RSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETG 472


>gi|4507475 transglutaminase 1 [Homo sapiens]
          Length = 817

 Score =  446 bits (1146), Expect = e-125
 Identities = 260/716 (36%), Positives = 387/716 (54%), Gaps = 50/716 (6%)

Query: 7   VALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETGPL 66
           V L   +S +N   HHT+E   D L+VRRGQ F++ L   +R+++   D I   +  G  
Sbjct: 115 VDLLSSRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLL-SRTYESS-DRITLELLIGNN 172

Query: 67  PDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSFQG 126
           P++  GT  +  + +  S   W A +      +  + +   P A +G++   +   S  G
Sbjct: 173 PEVGKGTHVIIPVGKGGSGG-WKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAG 231

Query: 127 SVTAYQL-----GEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPW 181
               +QL      E  +LFNPWCPED VY+D E  RQEYV+N+ G IY G++  I    W
Sbjct: 232 E---FQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTW 288

Query: 182 NYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGN 241
           NYGQF+  ++D CL +LD+              RG PV VSRV+ AM+NS DDNGVL GN
Sbjct: 289 NYGQFDHGVLDACLYILDRR-------GMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGN 341

Query: 242 WSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITN 301
           WS +Y+ G NP+ W GSV IL  +  TG   V YGQCWVFA V  TV+RCLG+ TR +TN
Sbjct: 342 WSGDYSRGTNPSAWVGSVEILLSYLRTGYS-VPYGQCWVFAGVTTTVLRCLGLATRTVTN 400

Query: 302 FDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDA 361
           F+S HDTD +L +D Y+D   + L +   D++WNFHVWN+CWM R DLP  + GWQV+DA
Sbjct: 401 FNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDA 460

Query: 362 TPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQG-GKEQKLHQDT 420
           TPQE S+G++CCGP SV +IK G V + YDTPF+F+ VN+D + W  Q  G  + ++ + 
Sbjct: 461 TPQETSSGIFCCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEE 520

Query: 421 SSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQP 480
            ++G  I TK+I S+ R+DIT  YK+ EGS  ER    KA++   A   HGS        
Sbjct: 521 KAIGTLIVTKAISSNMREDITYLYKHPEGSDAER----KAVETAAA---HGS-------- 565

Query: 481 SRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLK 540
            +P   +           +   D V             MGQD+   ++ +N SS  + +K
Sbjct: 566 -KPNVYANRGSAEDVAMQVEAQDAV-------------MGQDLMVSVMLINHSSSRRTVK 611

Query: 541 VNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALG 600
           ++L      + G   + F +    + L+P  +      ++Y +Y  +L     + ++  G
Sbjct: 612 LHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLVDQGAMLLNVSG 671

Query: 601 EEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGS 660
             K S + +       L  P +++ +LGAAVV Q   +Q++F NPL   + + V  +EGS
Sbjct: 672 HVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVTLTNVVFRLEGS 731

Query: 661 GLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 716
           GL ++ + + +G +      ++    VP + G RQ+ A++ S +   + G   V V
Sbjct: 732 GL-QRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHGVIQVDV 786


>gi|119395709 coagulation factor XIII A1 subunit precursor [Homo
           sapiens]
          Length = 732

 Score =  404 bits (1039), Expect = e-112
 Identities = 239/703 (33%), Positives = 363/703 (51%), Gaps = 40/703 (5%)

Query: 17  NNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETGPLPDLALGTRAV 76
           N V HHT++   + L+VRRGQ+F + + F +R + P  D        G  P    GT   
Sbjct: 61  NKVDHHTDKYENNKLIVRRGQSFYVQIDF-SRPYDPRRDLFRVEYVIGRYPQENKGTYIP 119

Query: 77  FSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSFQGSVTAYQLGEF 136
             +        W A +      S  +S+ + P   VG++ + + + +  G +   +  E 
Sbjct: 120 VPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPET 179

Query: 137 --ILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDIC 194
              +LFNPWC +DAVYLD+E +R+EYV+ND G I+ G  N I+   W+YGQFED I+D C
Sbjct: 180 DTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTC 239

Query: 195 LKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAE 254
           L ++D++         D + RG+P+ VSRV  AM+N+ DD GVL G+W   Y  G  P+ 
Sbjct: 240 LYVMDRA-------QMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSA 292

Query: 255 WTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLII 314
           WTGSV IL ++ ++   PVRYGQCWVFA V  T +RCLGIP R++TN+ S HD D NL +
Sbjct: 293 WTGSVDILLEYRSSE-NPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQM 351

Query: 315 DEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCG 374
           D + +  G +     KD++WN+H WNE WM R DLP  +GGWQ +D+TPQE S+G+Y CG
Sbjct: 352 DIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCG 411

Query: 375 PASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQ-GGKEQKLHQDTSSVGNFISTKSIQ 433
           PASV+AIK G V   +D PFVF+ VN+D +    +  G     + D + +G  I TK I 
Sbjct: 412 PASVQAIKHGHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIG 471

Query: 434 SDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRS 493
            D   DIT+ YK++EG  +ER                             T+L   + + 
Sbjct: 472 GDGMMDITDTYKFQEGQEEERLAL-------------------------ETALMYGAKKP 506

Query: 494 LHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHDGS 553
           L+T  +  S    V + F++ +   +G+D    +   N S     +   LSA    + G 
Sbjct: 507 LNTEGVMKSRS-NVDMDFEV-ENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGV 564

Query: 554 PLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNK 613
           P + F ++T  +TL P   K     I   +Y   L     +          + + +   K
Sbjct: 565 PKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINETRDVLAKQK 624

Query: 614 IITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGV 673
              L+ P I I V G  VV   +++ V F+NPL E + +  + ++G G+ +  +K+F  +
Sbjct: 625 STVLTIPEIIIKVRGTQVVGSDMTVTVEFTNPLKETLRNVWVHLDGPGVTRPMKKMFREI 684

Query: 674 LKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 716
            +P           P+ SG R++ A+M S+  + + G  +V +
Sbjct: 685 -RPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYGELDVQI 726


>gi|156627577 transglutaminase 4 (prostate) [Homo sapiens]
          Length = 684

 Score =  386 bits (992), Expect = e-107
 Identities = 239/718 (33%), Positives = 355/718 (49%), Gaps = 49/718 (6%)

Query: 5   LEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETG 64
           L+V   D  +  N V HHT E      + RRGQ F+L L   N+  Q     +     TG
Sbjct: 8   LQVLHIDFLNQDNAVSHHTWEFQTSSPVFRRGQVFHLRLVL-NQPLQ-SYHQLKLEFSTG 65

Query: 65  PLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSF 124
           P P +A  T  V           W A L+        V++ + P A +G+Y L +   + 
Sbjct: 66  PNPSIAKHTLVVLDPRTPSDHYNWQATLQNESGKEVTVAVTSSPNAILGKYQLNVKTGNH 125

Query: 125 QGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYG 184
              +   +     LLFNPWC ED V++  E +R+EY++ND G  Y G+   I+  PWN+G
Sbjct: 126 ---ILKSEENILYLLFNPWCKEDMVFMPDEDERKEYILNDTGCHYVGAARSIKCKPWNFG 182

Query: 185 QFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSE 244
           QFE  ++D C+ LL +S    TD       R  PV V R +CAM++     GVL GNW+ 
Sbjct: 183 QFEKNVLDCCISLLTESSLKPTD-------RRDPVLVCRAMCAMMSFEKGQGVLIGNWTG 235

Query: 245 NYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDS 304
           +Y  G  P +WTGS  IL+Q+  T  Q V +GQCWVFA ++ TV+R LGIP R +T FDS
Sbjct: 236 DYEGGTAPYKWTGSAPILQQYYNTK-QAVCFGQCWVFAGILTTVLRALGIPARSVTGFDS 294

Query: 305 GHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQ 364
            HDT+ NL +D Y +  G  + +   D++WNFHVW + WM R DLP  Y GWQ +DATPQ
Sbjct: 295 AHDTERNLTVDTYVNENGEKITSMTHDSVWNFHVWTDAWMKRPDLPKGYDGWQAVDATPQ 354

Query: 365 EMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQ--GGKEQ--KLHQDT 420
           E S GV+CCGP+ + AI++G++ + YDT FVFS VN D + WLV+   G+E+   +  +T
Sbjct: 355 ERSQGVFCCGPSPLTAIRKGDIFIVYDTRFVFSEVNGDRLIWLVKMVNGQEELHVISMET 414

Query: 421 SSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQP 480
           +S+G  ISTK++  D R DIT  YKY EGS +ERQV   A   L +   H          
Sbjct: 415 TSIGKNISTKAVGQDRRRDITYEYKYPEGSSEERQVMDHAFLLLSSEREH---------- 464

Query: 481 SRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLK 540
            RP          LH  S++  DV+             +G  + F ++    ++  +++ 
Sbjct: 465 RRPV-----KENFLHM-SVQSDDVL-------------LGNSVNFTVILKRKTAALQNVN 505

Query: 541 VNLSAQSLLHDGSPLSPF--WQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISA 598
           +  S +  L+ G  ++       T+ I     E        +Y      L  + +IR   
Sbjct: 506 ILGSFELQLYTGKKMAKLCDLNKTSQIQGQVSEVTLTLDSKTYINSLAILDDEPVIRGFI 565

Query: 599 LGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVE 658
           + E   S E +      +  YP  +I +     + Q L    IF N L+  + D   ++E
Sbjct: 566 IAEIVESKEIMASEVFTSFQYPEFSIELPNTGRIGQLLVCNCIFKNTLAIPLTDVKFSLE 625

Query: 659 GSGLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 716
             G+   Q     G ++P       ++  P K+G ++    + S + K+I   + V +
Sbjct: 626 SLGISSLQTSDH-GTVQPGETIQSQIKCTPIKTGPKKFIVKLSSKQVKEINAQKIVLI 682


>gi|166362737 erythrocyte membrane protein band 4.2 isoform 2 [Homo
           sapiens]
          Length = 691

 Score =  383 bits (983), Expect = e-106
 Identities = 234/719 (32%), Positives = 359/719 (49%), Gaps = 38/719 (5%)

Query: 1   MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRN--RSFQPGLDNII 58
           M Q L +   D Q++RNN  HHT+ ++   L VRRGQ F + LYFR   R+F P L  + 
Sbjct: 1   MGQALGIKSCDFQAARNNEEHHTKALSSRRLFVRRGQPFTIILYFRAPVRAFLPALKKVA 60

Query: 59  FVVETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLK 118
              +TG  P     T+A F ++       W A +E   A S  +S+  P  A +G Y L 
Sbjct: 61  LTAQTGEQPSKINRTQATFPISSLGDRKWWSAVVEERDAQSWTISVTTPADAVIGHYSLL 120

Query: 119 IHIDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRP 178
           + +   +  +    LG+F LLFNPW  EDAV+L +E QR EY++N  G IY G+ + I+ 
Sbjct: 121 LQVSGRKQLL----LGQFTLLFNPWNREDAVFLKNEAQRMEYLLNQNGLIYLGTADCIQA 176

Query: 179 CPWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVL 238
             W++GQFE  +ID+ L+LL K    +            PV+V+RV+ A+++   +  VL
Sbjct: 177 ESWDFGQFEGDVIDLSLRLLSKDKQVEK--------WSQPVHVARVLGALLHFLKEQRVL 228

Query: 239 NGNWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRV 298
               ++   +GA   +  GSV IL+QW     +PV  GQ WV AAV CTV+RCLGIP RV
Sbjct: 229 PTPQTQATQEGALLNKRRGSVPILRQWLTGRGRPVYDGQAWVLAAVACTVLRCLGIPARV 288

Query: 299 ITNFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQV 358
           +T F S   T G L+IDEYY+  G   G  ++  IW F    ECWM R  LP  Y GWQ+
Sbjct: 289 VTTFASAQGTGGRLLIDEYYNEEGLQNGEGQRGRIWIFQTSTECWMTRPALPQGYDGWQI 348

Query: 359 LDATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSW-LVQGGKEQKLH 417
           L  +       +  C    VRA+KEG + L      +F+ +NA C+ W   + G  +   
Sbjct: 349 LHPSAPNGGGVLGSCDLVPVRAVKEGTLGLTPAVSDLFAAINASCVVWKCCEDGTLELTD 408

Query: 418 QDTSSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAE 477
            +T  VGN ISTK + SD  +DIT+NYKY EGSLQE++V  +  ++   R      R   
Sbjct: 409 SNTKYVGNNISTKGVGSDRCEDITQNYKYPEGSLQEKEVLERVEKEKMEREKDNGIRPPS 468

Query: 478 LQPSRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFK 537
           L+ + P  L   +P SL    LR    + V+L                    +N S Q K
Sbjct: 469 LETASPLYLLLKAPSSL---PLRGDAQISVTL--------------------VNHSEQEK 505

Query: 538 DLKVNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRIS 597
            +++ +  Q++ ++G   +  W+    +TLS    K     + +S + +    +  +R++
Sbjct: 506 AVQLAIGVQAVHYNGVLAAKLWRKKLHLTLSANLEKIITIGLFFSNFERNPPENTFLRLT 565

Query: 598 ALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTV 657
           A+     S       + I +  P + I +   A   QPL+  V   N L   +EDCV+++
Sbjct: 566 AMATHSESNLSCFAQEDIAICRPHLAIKMPEKAEQYQPLTASVSLQNSLDAPMEDCVISI 625

Query: 658 EGSGLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 716
            G GL  +++      + P++      +  P   G +++   +  N F+++  Y++V V
Sbjct: 626 LGRGLIHRERSYRFRSVWPENTMCAKFQFTPTHVGLQRLTVEVDCNMFQNLTNYKSVTV 684


>gi|166362735 erythrocyte membrane protein band 4.2 isoform 1 [Homo
           sapiens]
          Length = 721

 Score =  379 bits (973), Expect = e-105
 Identities = 232/715 (32%), Positives = 357/715 (49%), Gaps = 38/715 (5%)

Query: 5   LEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRN--RSFQPGLDNIIFVVE 62
           L +   D Q++RNN  HHT+ ++   L VRRGQ F + LYFR   R+F P L  +    +
Sbjct: 35  LGIKSCDFQAARNNEEHHTKALSSRRLFVRRGQPFTIILYFRAPVRAFLPALKKVALTAQ 94

Query: 63  TGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHID 122
           TG  P     T+A F ++       W A +E   A S  +S+  P  A +G Y L + + 
Sbjct: 95  TGEQPSKINRTQATFPISSLGDRKWWSAVVEERDAQSWTISVTTPADAVIGHYSLLLQVS 154

Query: 123 SFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWN 182
             +  +    LG+F LLFNPW  EDAV+L +E QR EY++N  G IY G+ + I+   W+
Sbjct: 155 GRKQLL----LGQFTLLFNPWNREDAVFLKNEAQRMEYLLNQNGLIYLGTADCIQAESWD 210

Query: 183 YGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNW 242
           +GQFE  +ID+ L+LL K    +            PV+V+RV+ A+++   +  VL    
Sbjct: 211 FGQFEGDVIDLSLRLLSKDKQVEK--------WSQPVHVARVLGALLHFLKEQRVLPTPQ 262

Query: 243 SENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNF 302
           ++   +GA   +  GSV IL+QW     +PV  GQ WV AAV CTV+RCLGIP RV+T F
Sbjct: 263 TQATQEGALLNKRRGSVPILRQWLTGRGRPVYDGQAWVLAAVACTVLRCLGIPARVVTTF 322

Query: 303 DSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDAT 362
            S   T G L+IDEYY+  G   G  ++  IW F    ECWM R  LP  Y GWQ+L  +
Sbjct: 323 ASAQGTGGRLLIDEYYNEEGLQNGEGQRGRIWIFQTSTECWMTRPALPQGYDGWQILHPS 382

Query: 363 PQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSW-LVQGGKEQKLHQDTS 421
                  +  C    VRA+KEG + L      +F+ +NA C+ W   + G  +    +T 
Sbjct: 383 APNGGGVLGSCDLVPVRAVKEGTLGLTPAVSDLFAAINASCVVWKCCEDGTLELTDSNTK 442

Query: 422 SVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPS 481
            VGN ISTK + SD  +DIT+NYKY EGSLQE++V  +  ++   R      R   L+ +
Sbjct: 443 YVGNNISTKGVGSDRCEDITQNYKYPEGSLQEKEVLERVEKEKMEREKDNGIRPPSLETA 502

Query: 482 RPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKV 541
            P  L   +P SL    LR    + V+L                    +N S Q K +++
Sbjct: 503 SPLYLLLKAPSSL---PLRGDAQISVTL--------------------VNHSEQEKAVQL 539

Query: 542 NLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGE 601
            +  Q++ ++G   +  W+    +TLS    K     + +S + +    +  +R++A+  
Sbjct: 540 AIGVQAVHYNGVLAAKLWRKKLHLTLSANLEKIITIGLFFSNFERNPPENTFLRLTAMAT 599

Query: 602 EKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSG 661
              S       + I +  P + I +   A   QPL+  V   N L   +EDCV+++ G G
Sbjct: 600 HSESNLSCFAQEDIAICRPHLAIKMPEKAEQYQPLTASVSLQNSLDAPMEDCVISILGRG 659

Query: 662 LFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYV 716
           L  +++      + P++      +  P   G +++   +  N F+++  Y++V V
Sbjct: 660 LIHRERSYRFRSVWPENTMCAKFQFTPTHVGLQRLTVEVDCNMFQNLTNYKSVTV 714


>gi|154090979 hypothetical protein LOC57481 [Homo sapiens]
          Length = 1709

 Score = 32.7 bits (73), Expect = 1.2
 Identities = 31/124 (25%), Positives = 57/124 (45%), Gaps = 10/124 (8%)

Query: 406  WLVQGGKEQKLHQDTSSVGNFISTKSIQSDERDDITENYKYE-EGSLQERQVFLKALQKL 464
            W+    ++QK  +   SV   + TKS    + +  T+  KYE  GS  E Q      +K+
Sbjct: 1578 WITMAKQKQKSFKAHISVKE-LKTKSNAGADAE--TKEPKYEGAGSANENQP-----KKM 1629

Query: 465  KARSFHGSQRGAELQPSRPT-SLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDI 523
               S H  ++ A+++P +PT S+  ++ + L  P++        +L  K  +P    + +
Sbjct: 1630 FTSSVHKQEKTAQMKPPKPTKSVGFEAQKILQVPAMEKETKRSSTLPAKFQNPVEPIEPV 1689

Query: 524  CFVL 527
             F L
Sbjct: 1690 WFSL 1693


>gi|4507773 ubiquitin-conjugating enzyme E2D 1 [Homo sapiens]
          Length = 147

 Score = 31.6 bits (70), Expect = 2.7
 Identities = 26/80 (32%), Positives = 35/80 (43%), Gaps = 1/80 (1%)

Query: 493 SLHTPSLRPSDVVQVSLKFKLLDPP-NMGQDICFVLLALNMSSQFKDLKVNLSAQSLLHD 551
           ++H P+  P    +++   K+  P  N    IC  +L    S      KV LS  SLL D
Sbjct: 53  TVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCD 112

Query: 552 GSPLSPFWQDTAFITLSPKE 571
            +P  P   D A I  S KE
Sbjct: 113 PNPDDPLVPDIAQIYKSDKE 132


>gi|5453952 beta isoform of regulatory subunit B56, protein
           phosphatase 2A [Homo sapiens]
          Length = 497

 Score = 31.2 bits (69), Expect = 3.5
 Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 12/107 (11%)

Query: 390 YDTPFVFSMVNADC-------MSWLVQGGKEQKLHQDTSSVGNFIST-KSIQSDERDDIT 441
           ++  ++ S++  +C          L Q  KE       S + N + T   +     D++T
Sbjct: 381 WNNEYILSLIEDNCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELT 440

Query: 442 ENYKYE----EGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPT 484
            +YK E    +   QERQ   + L++L+ R   G+Q   E    R T
Sbjct: 441 ASYKLEKQQEQQKAQERQELWQGLEELRLRRLQGTQGAKEAPLQRLT 487


>gi|31541941 heat shock 70kDa protein 4-like [Homo sapiens]
          Length = 839

 Score = 30.8 bits (68), Expect = 4.6
 Identities = 13/25 (52%), Positives = 19/25 (76%)

Query: 441 TENYKYEEGSLQERQVFLKALQKLK 465
           TEN+ YE+G  Q +QV++  LQ+LK
Sbjct: 658 TENWLYEDGEDQPKQVYVDKLQELK 682


>gi|151101459 SAPS domain family, member 1 [Homo sapiens]
          Length = 881

 Score = 30.8 bits (68), Expect = 4.6
 Identities = 31/124 (25%), Positives = 54/124 (43%), Gaps = 17/124 (13%)

Query: 539 LKVNLSAQSLLHDGSP-LSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRIS 597
           L+  +S+   LH   P LS F Q    + L P   K  P ++++   +  L   +L  + 
Sbjct: 307 LESTVSSVGALHALRPRLSCFHQ----LLLEPP--KLEPLQMTWGMLAPPLGNTRLHVVK 360

Query: 598 ALGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTV 657
            L    S+ +  L ++++ L  P+  ++          L    +F+N L  QVE CV T+
Sbjct: 361 LLASALSANDAALTHELLALDVPNTMLD----------LFFHYVFNNFLHAQVEGCVSTM 410

Query: 658 EGSG 661
              G
Sbjct: 411 LSLG 414


>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
          Length = 586

 Score = 30.4 bits (67), Expect = 6.0
 Identities = 25/116 (21%), Positives = 43/116 (37%), Gaps = 13/116 (11%)

Query: 96  GATSTEVSLCAPPTAAVGRYLLKIHIDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEP 155
           G TS   +LC  PT      L+ +    +  +V  + LG  + +     P  + +     
Sbjct: 419 GETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVS 478

Query: 156 QRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLL--DKSLHFQTDPA 209
            + +     Y FI           P  + +  +K +D+  KLL  D    F T+ A
Sbjct: 479 LKDQITSGKYNFI-----------PEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 523


>gi|22209009 protein kinase CHK2 isoform b [Homo sapiens]
          Length = 514

 Score = 30.4 bits (67), Expect = 6.0
 Identities = 25/116 (21%), Positives = 43/116 (37%), Gaps = 13/116 (11%)

Query: 96  GATSTEVSLCAPPTAAVGRYLLKIHIDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEP 155
           G TS   +LC  PT      L+ +    +  +V  + LG  + +     P  + +     
Sbjct: 347 GETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVS 406

Query: 156 QRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLL--DKSLHFQTDPA 209
            + +     Y FI           P  + +  +K +D+  KLL  D    F T+ A
Sbjct: 407 LKDQITSGKYNFI-----------PEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 451


>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
          Length = 543

 Score = 30.4 bits (67), Expect = 6.0
 Identities = 25/116 (21%), Positives = 43/116 (37%), Gaps = 13/116 (11%)

Query: 96  GATSTEVSLCAPPTAAVGRYLLKIHIDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEP 155
           G TS   +LC  PT      L+ +    +  +V  + LG  + +     P  + +     
Sbjct: 376 GETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVS 435

Query: 156 QRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLL--DKSLHFQTDPA 209
            + +     Y FI           P  + +  +K +D+  KLL  D    F T+ A
Sbjct: 436 LKDQITSGKYNFI-----------PEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 480


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,535,819
Number of Sequences: 37866
Number of extensions: 1325999
Number of successful extensions: 2945
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2881
Number of HSP's gapped (non-prelim): 24
length of query: 720
length of database: 18,247,518
effective HSP length: 110
effective length of query: 610
effective length of database: 14,082,258
effective search space: 8590177380
effective search space used: 8590177380
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.