Search of human proteins with 94557301

Search of human proteins with 94557301

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
         (559 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub...  1137   0.0  
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub...  1127   0.0  
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   850   0.0  
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         290   2e-78
gi|116256471 SNF1-like kinase [Homo sapiens]                          280   2e-75
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               276   4e-74
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]              276   5e-74
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...   267   2e-71
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...   267   2e-71
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...   267   2e-71
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   266   5e-71
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   266   5e-71
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   266   5e-71
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   266   5e-71
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]        265   8e-71
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...   265   1e-70
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...   265   1e-70
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   263   4e-70
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]    255   9e-68
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   254   1e-67
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               247   2e-65
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]           244   2e-64
gi|156105707 SNF related kinase [Homo sapiens]                        216   3e-56
gi|156105705 SNF related kinase [Homo sapiens]                        216   3e-56
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]       213   5e-55
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa...   201   1e-51
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor...   181   1e-45
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo...   181   1e-45
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s...   176   4e-44
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca...   172   6e-43

>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 1 [Homo sapiens]
          Length = 559

 Score = 1137 bits (2942), Expect = 0.0
 Identities = 559/559 (100%), Positives = 559/559 (100%)

Query: 1   MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 60
           MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
Sbjct: 1   MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 60

Query: 61  QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 120
           QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
Sbjct: 61  QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 120

Query: 121 RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF 180
           RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
Sbjct: 121 RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF 180

Query: 181 LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG 240
           LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG
Sbjct: 181 LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG 240

Query: 241 IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID 300
           IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID
Sbjct: 241 IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID 300

Query: 301 DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS 360
           DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
Sbjct: 301 DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS 360

Query: 361 FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI 420
           FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI
Sbjct: 361 FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI 420

Query: 421 MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE 480
           MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE
Sbjct: 421 MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE 480

Query: 481 ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG 540
           ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG
Sbjct: 481 ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG 540

Query: 541 SHTIEFFEMCANLIKILAQ 559
           SHTIEFFEMCANLIKILAQ
Sbjct: 541 SHTIEFFEMCANLIKILAQ 559


>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 2 [Homo sapiens]
          Length = 574

 Score = 1127 bits (2916), Expect = 0.0
 Identities = 559/574 (97%), Positives = 559/574 (97%), Gaps = 15/574 (2%)

Query: 1   MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 60
           MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
Sbjct: 1   MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 60

Query: 61  QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 120
           QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
Sbjct: 61  QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 120

Query: 121 R---------------LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK 165
           R               LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK
Sbjct: 121 RKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK 180

Query: 166 IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF 225
           IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF
Sbjct: 181 IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF 240

Query: 226 DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK 285
           DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK
Sbjct: 241 DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK 300

Query: 286 YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM 345
           YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM
Sbjct: 301 YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM 360

Query: 346 NEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA 405
           NEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA
Sbjct: 361 NEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA 420

Query: 406 KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV 465
           KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV
Sbjct: 421 KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV 480

Query: 466 DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSV 525
           DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSV
Sbjct: 481 DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSV 540

Query: 526 TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ 559
           TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
Sbjct: 541 TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ 574


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  850 bits (2195), Expect = 0.0
 Identities = 421/553 (76%), Positives = 476/553 (86%), Gaps = 8/553 (1%)

Query: 13  AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72
           AEKQKHDGRVKIGHY+LGDTLGVGTFGKVK+G+H+LTGHKVAVKILNRQKIRSLDVVGKI
Sbjct: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61

Query: 73  RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 132
           +REIQNLKLFRHPHIIKLYQVISTP+D FMVMEYVSGGELFDYICK+GR++E E+RRLFQ
Sbjct: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121

Query: 133 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 192
           QILS VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA
Sbjct: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181

Query: 193 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 252
           PEVISGRLYAGPEVDIWS GVILYALLCGTLPFDD+HVPTLFKKI  G+FY P+YLN SV
Sbjct: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241

Query: 253 ISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFE 312
            +LL HMLQVDP+KRATIKDIREHEWFKQDLP YLFPEDPSY + +IDDEA+KEVCEKFE
Sbjct: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE 301

Query: 313 CSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-SFLDDHHL---- 367
           C+E EV++ LY+ + QD LAVAYHLIIDNRRIMN+A +FYLA+SPP  SF+DD  +    
Sbjct: 302 CTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPP 361

Query: 368 -TRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCR 426
             +PHPER+P L+A++P+AR  LD LN  K K   V+KAKWHLGIRSQS+P DIMAEV R
Sbjct: 362 GLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYR 421

Query: 427 AIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKS 486
           A+KQLD+EWKVVN Y+LRVRRKNPVT  Y KMSLQLY VD+R+YLLDF+SIDDE+ E +S
Sbjct: 422 AMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRS 481

Query: 487 GTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEF 546
           G++TPQRS S +     + S     A+  S   SLT S+T    S V  +PR GSHT++F
Sbjct: 482 GSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSV--SPRLGSHTMDF 539

Query: 547 FEMCANLIKILAQ 559
           FEMCA+LI  LA+
Sbjct: 540 FEMCASLITTLAR 552


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  290 bits (743), Expect = 2e-78
 Identities = 143/335 (42%), Positives = 216/335 (64%), Gaps = 6/335 (1%)

Query: 10  MATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVV 69
           MA   +    G V++G Y +  TLG G F  VK+G+H +T  +VA+KI+++ ++ ++++ 
Sbjct: 3   MADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLE 62

Query: 70  GKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRR 129
            KI RE+Q +K+  HPHIIKLYQV+ T S +++V EY   GE+FDY+  +GRL+E E+RR
Sbjct: 63  -KIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARR 121

Query: 130 LFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 189
            F QILS VDYCH   +VHRDLK EN+LLD +MN KIADFG  N    GE L T CGSP 
Sbjct: 122 KFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPP 181

Query: 190 YAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLN 249
           YAAPEV  G+ Y GP++DIWS GV+LY L+CG LPFD   +P L +++ +G F  P +++
Sbjct: 182 YAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMS 241

Query: 250 PSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP---KYLFPEDPSYSSTMID-DEALK 305
                L++ ML +DP KR TI  I+EH+W   ++P     L+P++     ++ + +E + 
Sbjct: 242 EDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVL 301

Query: 306 EVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIID 340
            +       +++ +  L N+++ +  A  Y L+++
Sbjct: 302 RLMHSLGIDQQKTIESLQNKSY-NHFAAIYFLLVE 335


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  280 bits (717), Expect = 2e-75
 Identities = 143/333 (42%), Positives = 212/333 (63%), Gaps = 7/333 (2%)

Query: 22  VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKL 81
           +++G Y +  TLG G F  VK+ +H +T  +VA+KI+++ ++ S ++  KI RE+Q +KL
Sbjct: 22  LRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE-KIYREVQLMKL 80

Query: 82  FRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYC 141
             HPHIIKLYQV+ T   +++V E+   GE+FDY+  NG L E E+R+ F QILS V+YC
Sbjct: 81  LNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYC 140

Query: 142 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 201
           H H +VHRDLK EN+LLD +M+ K+ADFG  N    GE L T CGSP YAAPEV  G+ Y
Sbjct: 141 HDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEY 200

Query: 202 AGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQ 261
            GP++DIWS GV+LY L+CG+LPFD  ++PTL +++ +G F  P +++    SL++ ML 
Sbjct: 201 EGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLV 260

Query: 262 VDPMKRATIKDIREHEWFKQD--LPKYLFP--EDPSYSSTMID-DEALKEVCEKFECSEE 316
           VDP +R TI  IR+H W + +  LP    P     SY+S + D DE    + +      +
Sbjct: 261 VDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQ 320

Query: 317 EVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAK 349
             +  L N ++ +  A  Y+L+++  +    A+
Sbjct: 321 RTVESLQNSSY-NHFAAIYYLLLERLKEYRNAQ 352


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  276 bits (706), Expect = 4e-74
 Identities = 150/367 (40%), Positives = 221/367 (60%), Gaps = 16/367 (4%)

Query: 24  IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 83
           +G Y L  TLG G  G VK+G H +TG KVA+KI+NR+K+ S  V+ K+ REI  LKL  
Sbjct: 31  VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 89

Query: 84  HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 143
           HPH++KL+ V      +++V+E+VSGGELFDY+ K GRL  KE+R+ F+QI+S +D+CH 
Sbjct: 90  HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149

Query: 144 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 203
           + + HRDLKPEN+LLD   N +IADFG++++      L TSCGSP+YA PEVI G  Y G
Sbjct: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209

Query: 204 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVD 263
              D+WS GVIL+ALL G LPFDDD++  L +K+  G+F+ P ++ P   SLL+ M++V+
Sbjct: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269

Query: 264 PMKRATIKDIREHEWF---KQDLPKYLFPEDPSY-------SSTMIDDEALKEVCEKFEC 313
           P KR +++ I++H W+   K +    L P            S+  +D + L+ +      
Sbjct: 270 PEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCF 329

Query: 314 SEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLA----TSPPDSFLDDHHLTR 369
            + E L        ++   + Y+L++D +      +D  L       PP   +D   L+R
Sbjct: 330 RDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSR 389

Query: 370 PHPERVP 376
            H +R P
Sbjct: 390 -HGKRRP 395


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score =  276 bits (705), Expect = 5e-74
 Identities = 155/368 (42%), Positives = 220/368 (59%), Gaps = 20/368 (5%)

Query: 24  IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 83
           +G Y L  TLG G  G VK+G H +T  KVA+KI+NR+K+ S  V+ K+ REI  LKL  
Sbjct: 16  VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 74

Query: 84  HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 143
           HPH++KL+ V      +++V+E+VSGGELFDY+ K GRL  KE+R+ F+QI+S +D+CH 
Sbjct: 75  HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 134

Query: 144 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 203
           H + HRDLKPEN+LLD   N +IADFG++++      L TSCGSP+YA PEVI G  Y G
Sbjct: 135 HSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 194

Query: 204 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVD 263
            + D+WS GVIL+ALL G LPFDDD++  L +K+  G+F+ P ++ P   SLL+ M++VD
Sbjct: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 254

Query: 264 PMKRATIKDIREHEWF--KQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSC 321
             +R T++ I++H W+   ++ P+   PE P      I      E  +         L C
Sbjct: 255 AARRLTLEHIQKHIWYIGGKNEPE---PEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGC 311

Query: 322 LYNRNH--QDPLA-------VAYHLIIDNRRIMNEAKDFYL----ATSPPDSFLDDHHLT 368
             +RN   QD L+       + Y L++D +      +D  L       PP   +D   L 
Sbjct: 312 FRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLN 371

Query: 369 RPHPERVP 376
           R H +R P
Sbjct: 372 R-HGKRRP 378


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score =  267 bits (682), Expect = 2e-71
 Identities = 153/389 (39%), Positives = 228/389 (58%), Gaps = 23/389 (5%)

Query: 12  TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
           +A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++ S  +  K
Sbjct: 43  SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96

Query: 72  IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 131
           + RE++ +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR+ EKE+R  F
Sbjct: 97  LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF 156

Query: 132 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 191
           +QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YA
Sbjct: 157 RQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 216

Query: 192 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 251
           APE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++  
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 276

Query: 252 VISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPEDPSYSSTMIDDEALKE 306
             +LLK  L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E
Sbjct: 277 CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDYK-----DPRRTE 330

Query: 307 VCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHH 366
           +      + EE+   L  + + + +A   +L++  +    E     L   P     D  +
Sbjct: 331 LMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTITLKPRPS---ADLTN 385

Query: 367 LTRPHP-ERVPFLVAETPRARHTLDELNP 394
            + P P  +V   V+  P+ R   D+  P
Sbjct: 386 SSAPSPSHKVQRSVSANPKQRRFSDQAGP 414


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score =  267 bits (682), Expect = 2e-71
 Identities = 153/389 (39%), Positives = 228/389 (58%), Gaps = 23/389 (5%)

Query: 12  TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
           +A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++ S  +  K
Sbjct: 43  SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96

Query: 72  IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 131
           + RE++ +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR+ EKE+R  F
Sbjct: 97  LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF 156

Query: 132 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 191
           +QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YA
Sbjct: 157 RQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 216

Query: 192 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 251
           APE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++  
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 276

Query: 252 VISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPEDPSYSSTMIDDEALKE 306
             +LLK  L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E
Sbjct: 277 CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDYK-----DPRRTE 330

Query: 307 VCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHH 366
           +      + EE+   L  + + + +A   +L++  +    E     L   P     D  +
Sbjct: 331 LMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTITLKPRPS---ADLTN 385

Query: 367 LTRPHP-ERVPFLVAETPRARHTLDELNP 394
            + P P  +V   V+  P+ R   D+  P
Sbjct: 386 SSAPSPSHKVQRSVSANPKQRRFSDQAGP 414


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score =  267 bits (682), Expect = 2e-71
 Identities = 153/389 (39%), Positives = 228/389 (58%), Gaps = 23/389 (5%)

Query: 12  TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
           +A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++ S  +  K
Sbjct: 10  SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 63

Query: 72  IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 131
           + RE++ +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR+ EKE+R  F
Sbjct: 64  LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF 123

Query: 132 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 191
           +QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YA
Sbjct: 124 RQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 183

Query: 192 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 251
           APE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++  
Sbjct: 184 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 243

Query: 252 VISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPEDPSYSSTMIDDEALKE 306
             +LLK  L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E
Sbjct: 244 CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDYK-----DPRRTE 297

Query: 307 VCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHH 366
           +      + EE+   L  + + + +A   +L++  +    E     L   P     D  +
Sbjct: 298 LMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTITLKPRPS---ADLTN 352

Query: 367 LTRPHP-ERVPFLVAETPRARHTLDELNP 394
            + P P  +V   V+  P+ R   D+  P
Sbjct: 353 SSAPSPSHKVQRSVSANPKQRRFSDQAGP 381


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  266 bits (679), Expect = 5e-71
 Identities = 146/386 (37%), Positives = 229/386 (59%), Gaps = 19/386 (4%)

Query: 19  DGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQN 78
           D +  IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++    +  K+ RE++ 
Sbjct: 52  DEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRI 110

Query: 79  LKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 138
           +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR+ EKE+R  F+QI+S V
Sbjct: 111 MKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 170

Query: 139 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 198
            YCH+  +VHRDLK EN+LLD  MN KIADFG SN  + G  L T CGSP YAAPE+  G
Sbjct: 171 QYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQG 230

Query: 199 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKH 258
           + Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++    +LLK 
Sbjct: 231 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 290

Query: 259 MLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFEC 313
           +L ++P+KR +++ I +  W      +++L  Y  P DP ++ T   D     +      
Sbjct: 291 LLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEP-DPDFNDTKRID-----IMVTMGF 344

Query: 314 SEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLA-----TSPPDSFLDDHHLT 368
           + +E+   L N+ + + +A   ++++  +    E  +   +      S P S L++  L 
Sbjct: 345 ARDEINDALINQKYDEVMAT--YILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQ 402

Query: 369 RPHPERVPFLVAETPRARHTLDELNP 394
            P   +V   ++   + R   D   P
Sbjct: 403 SPAHLKVQRSISANQKQRRFSDHAGP 428


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  266 bits (679), Expect = 5e-71
 Identities = 151/393 (38%), Positives = 230/393 (58%), Gaps = 26/393 (6%)

Query: 13  AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72
           A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VA+KI+++ ++    +  K+
Sbjct: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100

Query: 73  RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 132
            RE++ +K+  HP+I+KL++VI T   ++++MEY SGGE+FDY+  +GR+ EKE+R  F+
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160

Query: 133 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 192
           QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220

Query: 193 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 252
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++   
Sbjct: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 280

Query: 253 ISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDPSYSSTMIDDEALKEV 307
            +LLK  L ++P+KR T++ I +  W      + +L  ++ PE        I D+   ++
Sbjct: 281 ENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPE------LDISDQKRIDI 334

Query: 308 CEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKD------FYLATSPPDSF 361
                 S+EE+   L    + +    A +L++  +    +A D        LA   P S 
Sbjct: 335 MVGMGYSQEEIQESLSKMKYDE--ITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSD 392

Query: 362 LDDHHLTRPHPERVPFLVAETPRARHTLDELNP 394
           L++     PH  +V   V  + + R   D   P
Sbjct: 393 LNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGP 424


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  266 bits (679), Expect = 5e-71
 Identities = 151/393 (38%), Positives = 230/393 (58%), Gaps = 26/393 (6%)

Query: 13  AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72
           A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VA+KI+++ ++    +  K+
Sbjct: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100

Query: 73  RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 132
            RE++ +K+  HP+I+KL++VI T   ++++MEY SGGE+FDY+  +GR+ EKE+R  F+
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160

Query: 133 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 192
           QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220

Query: 193 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 252
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++   
Sbjct: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 280

Query: 253 ISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDPSYSSTMIDDEALKEV 307
            +LLK  L ++P+KR T++ I +  W      + +L  ++ PE        I D+   ++
Sbjct: 281 ENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPE------LDISDQKRIDI 334

Query: 308 CEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKD------FYLATSPPDSF 361
                 S+EE+   L    + +    A +L++  +    +A D        LA   P S 
Sbjct: 335 MVGMGYSQEEIQESLSKMKYDE--ITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSD 392

Query: 362 LDDHHLTRPHPERVPFLVAETPRARHTLDELNP 394
           L++     PH  +V   V  + + R   D   P
Sbjct: 393 LNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGP 424


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  266 bits (679), Expect = 5e-71
 Identities = 151/393 (38%), Positives = 230/393 (58%), Gaps = 26/393 (6%)

Query: 13  AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72
           A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VA+KI+++ ++    +  K+
Sbjct: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100

Query: 73  RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 132
            RE++ +K+  HP+I+KL++VI T   ++++MEY SGGE+FDY+  +GR+ EKE+R  F+
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160

Query: 133 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 192
           QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220

Query: 193 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 252
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++   
Sbjct: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 280

Query: 253 ISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDPSYSSTMIDDEALKEV 307
            +LLK  L ++P+KR T++ I +  W      + +L  ++ PE        I D+   ++
Sbjct: 281 ENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPE------LDISDQKRIDI 334

Query: 308 CEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKD------FYLATSPPDSF 361
                 S+EE+   L    + +    A +L++  +    +A D        LA   P S 
Sbjct: 335 MVGMGYSQEEIQESLSKMKYDE--ITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSD 392

Query: 362 LDDHHLTRPHPERVPFLVAETPRARHTLDELNP 394
           L++     PH  +V   V  + + R   D   P
Sbjct: 393 LNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGP 424


>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
          Length = 1263

 Score =  265 bits (677), Expect = 8e-71
 Identities = 132/298 (44%), Positives = 199/298 (66%), Gaps = 7/298 (2%)

Query: 23  KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 82
           +IG+Y +  T+G G F  VK   H +T  KVA+KI+++ ++   + + KI RE+Q +K+ 
Sbjct: 4   RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDE-ENLKKIFREVQIMKML 62

Query: 83  RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 142
            HPHII+LYQV+ T   I++V EY SGGE+FD++  +GR+ EKE+RR F+QI++ V +CH
Sbjct: 63  CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH 122

Query: 143 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 202
              +VHRDLK EN+LLDA++N KIADFG SN+ + G+ L+T CGSP YAAPE+  G+ Y 
Sbjct: 123 CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD 182

Query: 203 GPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQV 262
           GP+VDIWS GV+LY L+CG LPFD   +  L  ++  G F  P +++     L++HML +
Sbjct: 183 GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL 242

Query: 263 DPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLS 320
           DP KR +++ I +H+W K      L   DP++   + + + LKE  +    +E+ +L+
Sbjct: 243 DPNKRLSMEQICKHKWMK------LGDADPNFDRLIAECQQLKEERQVDPLNEDVLLA 294


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score =  265 bits (676), Expect = 1e-70
 Identities = 152/386 (39%), Positives = 227/386 (58%), Gaps = 23/386 (5%)

Query: 12  TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
           +A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++ S  +  K
Sbjct: 43  SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96

Query: 72  IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 131
           + RE++ +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR+ EKE+R  F
Sbjct: 97  LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF 156

Query: 132 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 191
           +QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YA
Sbjct: 157 RQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 216

Query: 192 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 251
           APE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++  
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 276

Query: 252 VISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPEDPSYSSTMIDDEALKE 306
             +LLK  L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E
Sbjct: 277 CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDYK-----DPRRTE 330

Query: 307 VCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHH 366
           +      + EE+   L  + + + +A   +L++  +    E     L   P     D  +
Sbjct: 331 LMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTITLKPRPS---ADLTN 385

Query: 367 LTRPHP-ERVPFLVAETPRARHTLDE 391
            + P P  +V   V+  P+ R   D+
Sbjct: 386 SSAPSPSHKVQRSVSANPKQRRFSDQ 411


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score =  265 bits (676), Expect = 1e-70
 Identities = 152/386 (39%), Positives = 227/386 (58%), Gaps = 23/386 (5%)

Query: 12  TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
           +A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VAVKI+++ ++ S  +  K
Sbjct: 43  SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96

Query: 72  IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 131
           + RE++ +K+  HP+I+KL++VI T   +++VMEY SGGE+FDY+  +GR+ EKE+R  F
Sbjct: 97  LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF 156

Query: 132 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 191
           +QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YA
Sbjct: 157 RQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 216

Query: 192 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 251
           APE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++  
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 276

Query: 252 VISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPEDPSYSSTMIDDEALKE 306
             +LLK  L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E
Sbjct: 277 CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDYK-----DPRRTE 330

Query: 307 VCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHH 366
           +      + EE+   L  + + + +A   +L++  +    E     L   P     D  +
Sbjct: 331 LMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTITLKPRPS---ADLTN 385

Query: 367 LTRPHP-ERVPFLVAETPRARHTLDE 391
            + P P  +V   V+  P+ R   D+
Sbjct: 386 SSAPSPSHKVQRSVSANPKQRRFSDQ 411


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  263 bits (671), Expect = 4e-70
 Identities = 138/331 (41%), Positives = 209/331 (63%), Gaps = 18/331 (5%)

Query: 13  AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72
           A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VA+KI+++ ++    +  K+
Sbjct: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100

Query: 73  RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 132
            RE++ +K+  HP+I+KL++VI T   ++++MEY SGGE+FDY+  +GR+ EKE+R  F+
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160

Query: 133 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 192
           QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220

Query: 193 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 252
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++   
Sbjct: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 280

Query: 253 ISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDPSYSSTMIDDEALKEV 307
            +LLK  L ++P+KR T++ I +  W      + +L  ++ PE        I D+   ++
Sbjct: 281 ENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPE------LDISDQKRIDI 334

Query: 308 CEKFECSEEEVLSCLYNRNHQDPLAVAYHLI 338
                 S+EE+   L ++   D +   Y L+
Sbjct: 335 MVGMGYSQEEIQESL-SKMKYDEITATYLLL 364


>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
          Length = 651

 Score =  255 bits (651), Expect = 9e-68
 Identities = 139/318 (43%), Positives = 195/318 (61%), Gaps = 10/318 (3%)

Query: 26  HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 85
           +Y L +T+G G F KVK+  H LTG  VA+KI+++  + S   + +I+ EI+ LK  RH 
Sbjct: 10  YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLRHQ 67

Query: 86  HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 145
           HI +LY V+ T + IFMV+EY  GGELFDYI    RL E+E+R +F+QI+S V Y H   
Sbjct: 68  HICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 127

Query: 146 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE--FLRTSCGSPNYAAPEVISGRLYAG 203
             HRDLKPEN+L D +   K+ DFGL       +   L+T CGS  YAAPE+I G+ Y G
Sbjct: 128 YAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLG 187

Query: 204 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVD 263
            E D+WS G++LY L+CG LPFDDD+V  L+KKI  G +  P++L+PS I LL+ MLQVD
Sbjct: 188 SEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVD 247

Query: 264 PMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMI--DDEALKEVCEKFECSEEEVLSC 321
           P KR ++K++  H W  QD   Y +P +    +  I  DD+ + E+      +  + +  
Sbjct: 248 PKKRISMKNLLNHPWIMQD---YNYPVEWQSKNPFIHLDDDCVTELSVHHR-NNRQTMED 303

Query: 322 LYNRNHQDPLAVAYHLII 339
           L +    D L   Y L++
Sbjct: 304 LISLWQYDHLTATYLLLL 321


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  254 bits (649), Expect = 1e-67
 Identities = 128/283 (45%), Positives = 187/283 (66%), Gaps = 11/283 (3%)

Query: 14  EKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIR 73
           E+Q H     +G+Y L  T+G G F KVK+ +H LTG +VA+KI+++ ++    +  K+ 
Sbjct: 51  EEQPH-----VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLF 104

Query: 74  REIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQ 133
           RE++ +K   HP+I+KL++VI T   +++VMEY S GE+FDY+  +GR+ EKE+R  F+Q
Sbjct: 105 REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQ 164

Query: 134 ILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAP 193
           I+S V YCH+  +VHRDLK EN+LLDA  N KIADFG SN  + G  L T CGSP YAAP
Sbjct: 165 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAP 224

Query: 194 EVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVI 253
           E+  G+ Y GPEVDIWS GVILY L+ G+LPFD  ++  L +++  G +  P Y++    
Sbjct: 225 ELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCE 284

Query: 254 SLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 291
           S+L+  L ++P KR T++ I + +W       ++L  Y  PE+
Sbjct: 285 SILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEE 327


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  247 bits (630), Expect = 2e-65
 Identities = 135/315 (42%), Positives = 192/315 (60%), Gaps = 22/315 (6%)

Query: 16  QKHDGRVKIGH-YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
           ++H  +  + H Y L +TLG GT+GKVK      +G  VA+K + + KI+    +  IRR
Sbjct: 43  KRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRR 102

Query: 75  EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQI 134
           EI+ +    HPHII +Y+V      I ++MEY S GEL+DYI +  RL E+E+R  F+QI
Sbjct: 103 EIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQI 162

Query: 135 LSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 194
           +S V YCH++ VVHRDLK EN+LLD + N KIADFGLSN+    +FL+T CGSP YA+PE
Sbjct: 163 VSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPE 222

Query: 195 VISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS-VI 253
           +++GR Y GPEVD W+ GV+LY L+ GT+PFD      L ++I  G +  P    PS   
Sbjct: 223 IVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP--TQPSDAR 280

Query: 254 SLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFEC 313
            L++ ML V+P +RATI+DI  H W               Y S++ D +AL +       
Sbjct: 281 GLIRWMLMVNPDRRATIEDIANHWWVNW-----------GYKSSVCDCDALHD------- 322

Query: 314 SEEEVLSCLYNRNHQ 328
           SE  +L+ + + +H+
Sbjct: 323 SESPLLARIIDWHHR 337


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score =  244 bits (623), Expect = 2e-64
 Identities = 125/265 (47%), Positives = 178/265 (67%), Gaps = 5/265 (1%)

Query: 16  QKHDGRVKIGH-YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
           ++H  +  + H Y   +TLG GT+GKVK  + E +G  VA+K + + KI+    +  IRR
Sbjct: 41  KRHHHKHNLRHRYEFLETLGKGTYGKVKKAR-ESSGRLVAIKSIRKDKIKDEQDLMHIRR 99

Query: 75  EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQI 134
           EI+ +    HPHII +++V    S I +VMEY S G+L+DYI +  +L E+E+R  F+QI
Sbjct: 100 EIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQI 159

Query: 135 LSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 194
           +S V YCH++ VVHRDLK EN+LLDA+ N KIADFGLSN+   G+FL+T CGSP YA+PE
Sbjct: 160 VSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPE 219

Query: 195 VISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS-VI 253
           +++G+ Y GPEVD WS GV+LY L+ GT+PFD      L K+I +G +  P    PS   
Sbjct: 220 IVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPP--KPSDAC 277

Query: 254 SLLKHMLQVDPMKRATIKDIREHEW 278
            L++ +L V+P +RAT++D+  H W
Sbjct: 278 GLIRWLLMVNPTRRATLEDVASHWW 302


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  216 bits (551), Expect = 3e-56
 Identities = 123/350 (35%), Positives = 200/350 (57%), Gaps = 16/350 (4%)

Query: 15  KQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
           K+ +DG++  G Y L  TLG G F  VK+ +H  TG KVAVK++++ K+ +L   G + +
Sbjct: 5   KRGYDGKIA-GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQ 62

Query: 75  EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR-LDEKESRRLFQQ 133
           E++ +KL +HP+I++LY+VI T + +++++E   GG++FDYI K+   L+E  +++ F Q
Sbjct: 63  EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 122

Query: 134 ILSGVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAA 192
           I+  + YCH+  VVHRDLKPENV+        K+ DFG SN    G+ L TSCGS  Y+A
Sbjct: 123 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSA 182

Query: 193 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 252
           PE++ G  Y  P VDIWS GVIL+ L+CG  PF + +       I D  +  P +++   
Sbjct: 183 PEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKEC 242

Query: 253 ISLLKHMLQVDPMKRATIKDIREHEWFKQDLP----KYLFPEDPSYSSTMIDDEALKEVC 308
             L+  MLQ DP +RA++++I  H W +   P    KY     P  S   + +E    + 
Sbjct: 243 KDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKY---NIPLVSYKNLSEEEHNSII 299

Query: 309 EKF---ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLAT 355
           ++    + ++ + +      N  + +   Y L+ +  RI+ E ++  + T
Sbjct: 300 QRMVLGDIADRDAIVEALETNRYNHITATYFLLAE--RILREKQEKEIQT 347


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  216 bits (551), Expect = 3e-56
 Identities = 123/350 (35%), Positives = 200/350 (57%), Gaps = 16/350 (4%)

Query: 15  KQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
           K+ +DG++  G Y L  TLG G F  VK+ +H  TG KVAVK++++ K+ +L   G + +
Sbjct: 5   KRGYDGKIA-GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQ 62

Query: 75  EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR-LDEKESRRLFQQ 133
           E++ +KL +HP+I++LY+VI T + +++++E   GG++FDYI K+   L+E  +++ F Q
Sbjct: 63  EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 122

Query: 134 ILSGVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAA 192
           I+  + YCH+  VVHRDLKPENV+        K+ DFG SN    G+ L TSCGS  Y+A
Sbjct: 123 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSA 182

Query: 193 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 252
           PE++ G  Y  P VDIWS GVIL+ L+CG  PF + +       I D  +  P +++   
Sbjct: 183 PEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKEC 242

Query: 253 ISLLKHMLQVDPMKRATIKDIREHEWFKQDLP----KYLFPEDPSYSSTMIDDEALKEVC 308
             L+  MLQ DP +RA++++I  H W +   P    KY     P  S   + +E    + 
Sbjct: 243 KDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKY---NIPLVSYKNLSEEEHNSII 299

Query: 309 EKF---ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLAT 355
           ++    + ++ + +      N  + +   Y L+ +  RI+ E ++  + T
Sbjct: 300 QRMVLGDIADRDAIVEALETNRYNHITATYFLLAE--RILREKQEKEIQT 347


>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
          Length = 436

 Score =  213 bits (541), Expect = 5e-55
 Identities = 122/324 (37%), Positives = 183/324 (56%), Gaps = 9/324 (2%)

Query: 23  KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 82
           +IG Y +   +G G F +VK+G H LT  KVA+KIL++ K+        + REI +++  
Sbjct: 70  RIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQ-KTQRLLSREISSMEKL 128

Query: 83  RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 142
            HP+II+LY+V+ T S + +VMEY  GGELF  I   G+L E ES+ +F QI+S V + H
Sbjct: 129 HHPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMH 188

Query: 143 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 202
            + ++HRDLK ENV   ++   K+ DFG S +   GE L T CGSP YAAPE+     Y 
Sbjct: 189 ENQIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYI 248

Query: 203 GPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQV 262
           G  VDIW+ GV+LY ++ GT+PF  + V  L K I +G +  P +++     L++ +LQ 
Sbjct: 249 GIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQ 308

Query: 263 DPMKRATIKDIREHEWFK---QDLPKYLFPEDP---SYSSTMIDDE-ALKEVCEKFECSE 315
            P +R  I  I   EW +      P   F  DP   S +ST+ ++E  +K   E    +E
Sbjct: 309 IPTERYGIDCIMNDEWMQGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTLEHLGITE 368

Query: 316 EEVLSCLYNRNHQDPLAVAYHLII 339
           E + +    R+ +  +   Y +I+
Sbjct: 369 EHIRN-NQGRDARSSITGVYRIIL 391


>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
           sapiens]
          Length = 714

 Score =  201 bits (511), Expect = 1e-51
 Identities = 109/268 (40%), Positives = 171/268 (63%), Gaps = 9/268 (3%)

Query: 23  KIGHYILGDT-LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK-IRREIQNLK 80
           ++G+Y++G   LG G+F KV+ G H LTG KVA+K++++++ +    V K +RRE Q  +
Sbjct: 57  RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116

Query: 81  LFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 140
           + RHP+I +L  ++ T +  ++VME   GG L   I +  RL+E E+RR  +Q++S V++
Sbjct: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176

Query: 141 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVIS 197
            HR  VVHRDLK EN+LLD   N K+ DFGLSN   ++   +   T CGSP YAAPE+++
Sbjct: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236

Query: 198 GRLYAGPEVDIWSSGVILYALLCGTLPF--DDDHVPTLFKKICD-GIFYTPQYLNPSVIS 254
            + Y GP++D+WS GV +YA+L GTLPF  +   +  L++K+ D  +   P  L+   IS
Sbjct: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295

Query: 255 LLKHMLQVDPMKRATIKDIREHEWFKQD 282
            L+ +L+ DP+KR  I+    + W  ++
Sbjct: 296 FLRSLLEPDPVKRPNIQQALANRWLNEN 323


>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
           [Homo sapiens]
          Length = 357

 Score =  181 bits (460), Expect = 1e-45
 Identities = 104/285 (36%), Positives = 162/285 (56%), Gaps = 19/285 (6%)

Query: 5   SSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIR 64
           SSW+K A   K+  + +         +TLG G F +V + + + TG   AVK + ++ ++
Sbjct: 10  SSWKKQAEDIKKIFEFK---------ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 60

Query: 65  SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDE 124
             +    I  EI  L+  +H +I+ L  +  +P+ +++VM+ VSGGELFD I + G   E
Sbjct: 61  GKE--SSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTE 118

Query: 125 KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFL 181
           K++  L +Q+L  V Y HR  +VHRDLKPEN+L    D      I+DFGLS M   G+ +
Sbjct: 119 KDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVM 178

Query: 182 RTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI--CD 239
            T+CG+P Y APEV++ + Y+   VD WS GVI Y LLCG  PF D++   LF++I   +
Sbjct: 179 STACGTPGYVAPEVLAQKPYS-KAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAE 237

Query: 240 GIFYTPQY--LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD 282
             F +P +  ++ S    ++++++ DP KR T +    H W   D
Sbjct: 238 YEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGD 282


>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
           2 [Homo sapiens]
          Length = 385

 Score =  181 bits (460), Expect = 1e-45
 Identities = 104/285 (36%), Positives = 162/285 (56%), Gaps = 19/285 (6%)

Query: 5   SSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIR 64
           SSW+K A   K+  + +         +TLG G F +V + + + TG   AVK + ++ ++
Sbjct: 10  SSWKKQAEDIKKIFEFK---------ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 60

Query: 65  SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDE 124
             +    I  EI  L+  +H +I+ L  +  +P+ +++VM+ VSGGELFD I + G   E
Sbjct: 61  GKE--SSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTE 118

Query: 125 KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFL 181
           K++  L +Q+L  V Y HR  +VHRDLKPEN+L    D      I+DFGLS M   G+ +
Sbjct: 119 KDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVM 178

Query: 182 RTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI--CD 239
            T+CG+P Y APEV++ + Y+   VD WS GVI Y LLCG  PF D++   LF++I   +
Sbjct: 179 STACGTPGYVAPEVLAQKPYS-KAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAE 237

Query: 240 GIFYTPQY--LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD 282
             F +P +  ++ S    ++++++ DP KR T +    H W   D
Sbjct: 238 YEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGD 282


>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
           sapiens]
          Length = 370

 Score =  176 bits (447), Expect = 4e-44
 Identities = 99/263 (37%), Positives = 150/263 (57%), Gaps = 10/263 (3%)

Query: 27  YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
           Y   D LG G F +V + + + T   VA+K + ++ +   +  G +  EI  L   +HP+
Sbjct: 20  YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE--GSMENEIAVLHKIKHPN 77

Query: 87  IIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMV 146
           I+ L  +  +   ++++M+ VSGGELFD I + G   E+++ RL  Q+L  V Y H   +
Sbjct: 78  IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137

Query: 147 VHRDLKPENVL---LDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 203
           VHRDLKPEN+L   LD      I+DFGLS M   G  L T+CG+P Y APEV++ + Y+ 
Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYS- 196

Query: 204 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI--CDGIFYTPQY--LNPSVISLLKHM 259
             VD WS GVI Y LLCG  PF D++   LF++I   +  F +P +  ++ S    ++H+
Sbjct: 197 KAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHL 256

Query: 260 LQVDPMKRATIKDIREHEWFKQD 282
           ++ DP KR T +   +H W   D
Sbjct: 257 MEKDPEKRFTCEQALQHPWIAGD 279


>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform b [Homo sapiens]
          Length = 360

 Score =  172 bits (437), Expect = 6e-43
 Identities = 98/263 (37%), Positives = 148/263 (56%), Gaps = 11/263 (4%)

Query: 27  YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
           Y + + LG G F +V + +   + H VA+K + ++ +R  + +  +  EI  L+   HP+
Sbjct: 32  YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEAL--VENEIAVLRRISHPN 89

Query: 87  IIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMV 146
           I+ L  V  +PS +++ ME V+GGELFD I + G   EK++  L  Q+L  V Y H   +
Sbjct: 90  IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGI 149

Query: 147 VHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 203
           VHRDLKPEN+L           ++DFGLS + + G  L T+CG+P Y APE++  + Y G
Sbjct: 150 VHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPELLEQKPY-G 207

Query: 204 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI--FYTPQY--LNPSVISLLKHM 259
             VD+W+ GVI Y LLCG  PF D+  P LF +I      F +P +  ++ S    ++H+
Sbjct: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267

Query: 260 LQVDPMKRATIKDIREHEWFKQD 282
           L+ DP KR T +    H W   D
Sbjct: 268 LERDPQKRFTCQQALRHLWISGD 290


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,156,859
Number of Sequences: 37866
Number of extensions: 1004458
Number of successful extensions: 5061
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 733
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 2633
Number of HSP's gapped (non-prelim): 991
length of query: 559
length of database: 18,247,518
effective HSP length: 107
effective length of query: 452
effective length of database: 14,195,856
effective search space: 6416526912
effective search space used: 6416526912
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.