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Search of human proteins with 94557299
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
(574 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 1166 0.0
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 1127 0.0
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 840 0.0
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 280 2e-75
gi|116256471 SNF1-like kinase [Homo sapiens] 270 2e-72
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 266 4e-71
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 266 5e-71
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 257 2e-68
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 257 2e-68
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 257 2e-68
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 256 5e-68
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 256 5e-68
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 256 5e-68
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 256 5e-68
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 255 9e-68
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 254 1e-67
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 254 1e-67
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 253 4e-67
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 245 9e-65
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 244 2e-64
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 237 2e-62
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 236 6e-62
gi|156105707 SNF related kinase [Homo sapiens] 211 1e-54
gi|156105705 SNF related kinase [Homo sapiens] 211 1e-54
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 202 5e-52
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 192 9e-49
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 172 1e-42
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 172 1e-42
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 167 3e-41
gi|4507271 serine/threonine protein kinase 11 [Homo sapiens] 164 2e-40
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 1166 bits (3017), Expect = 0.0
Identities = 574/574 (100%), Positives = 574/574 (100%)
Query: 1 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 60
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
Sbjct: 1 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 60
Query: 61 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 120
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
Sbjct: 61 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 120
Query: 121 RKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK 180
RKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK
Sbjct: 121 RKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK 180
Query: 181 IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF 240
IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF
Sbjct: 181 IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF 240
Query: 241 DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK 300
DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK
Sbjct: 241 DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK 300
Query: 301 YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM 360
YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM
Sbjct: 301 YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM 360
Query: 361 NEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA 420
NEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA
Sbjct: 361 NEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA 420
Query: 421 KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV 480
KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV
Sbjct: 421 KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV 480
Query: 481 DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSV 540
DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSV
Sbjct: 481 DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSV 540
Query: 541 TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ 574
TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
Sbjct: 541 TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ 574
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 1127 bits (2916), Expect = 0.0
Identities = 559/574 (97%), Positives = 559/574 (97%), Gaps = 15/574 (2%)
Query: 1 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 60
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
Sbjct: 1 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 60
Query: 61 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 120
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
Sbjct: 61 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 120
Query: 121 RKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK 180
R LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK
Sbjct: 121 R---------------LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK 165
Query: 181 IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF 240
IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF
Sbjct: 166 IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF 225
Query: 241 DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK 300
DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK
Sbjct: 226 DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK 285
Query: 301 YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM 360
YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM
Sbjct: 286 YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM 345
Query: 361 NEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA 420
NEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA
Sbjct: 346 NEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA 405
Query: 421 KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV 480
KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV
Sbjct: 406 KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV 465
Query: 481 DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSV 540
DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSV
Sbjct: 466 DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSV 525
Query: 541 TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ 574
TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
Sbjct: 526 TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ 559
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 840 bits (2169), Expect = 0.0
Identities = 421/568 (74%), Positives = 476/568 (83%), Gaps = 23/568 (4%)
Query: 13 AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72
AEKQKHDGRVKIGHY+LGDTLGVGTFGKVK+G+H+LTGHKVAVKILNRQKIRSLDVVGKI
Sbjct: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
Query: 73 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTG 132
+REIQNLKLFRHPHIIKLYQVISTP+D FMVMEYVSGGELFDYICK+GR
Sbjct: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----------- 110
Query: 133 STKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 192
++E E+RRLFQQILS VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD
Sbjct: 111 ----VEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 166
Query: 193 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 252
GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS GVILYALLCGTLPFDD+HVPTLFKKI
Sbjct: 167 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI 226
Query: 253 CDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSST 312
G+FY P+YLN SV +LL HMLQVDP+KRATIKDIREHEWFKQDLP YLFPEDPSY +
Sbjct: 227 RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDAN 286
Query: 313 MIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSP 372
+IDDEA+KEVCEKFEC+E EV++ LY+ + QD LAVAYHLIIDNRRIMN+A +FYLA+SP
Sbjct: 287 VIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSP 346
Query: 373 PD-SFLDDHHL-----TRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGI 426
P SF+DD + +PHPER+P L+A++P+AR LD LN K K V+KAKWHLGI
Sbjct: 347 PSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGI 406
Query: 427 RSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYL 486
RSQS+P DIMAEV RA+KQLD+EWKVVN Y+LRVRRKNPVT Y KMSLQLY VD+R+YL
Sbjct: 407 RSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYL 466
Query: 487 LDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSS 546
LDF+SIDDE+ E +SG++TPQRS S + + S A+ S SLT S+T S
Sbjct: 467 LDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLS 526
Query: 547 PVDLTPRPGSHTIEFFEMCANLIKILAQ 574
V +PR GSHT++FFEMCA+LI LA+
Sbjct: 527 SV--SPRLGSHTMDFFEMCASLITTLAR 552
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 280 bits (717), Expect = 2e-75
Identities = 143/350 (40%), Positives = 216/350 (61%), Gaps = 21/350 (6%)
Query: 10 MATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVV 69
MA + G V++G Y + TLG G F VK+G+H +T +VA+KI+++ ++ ++++
Sbjct: 3 MADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLE 62
Query: 70 GKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVV 129
KI RE+Q +K+ HPHIIKLYQV+ T S +++V EY GE+FDY+ +GR
Sbjct: 63 -KIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGR-------- 113
Query: 130 KTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM 189
L+E E+RR F QILS VDYCH +VHRDLK EN+LLD +MN KIADFG N
Sbjct: 114 -------LNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNF 166
Query: 190 MSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLF 249
GE L T CGSP YAAPEV G+ Y GP++DIWS GV+LY L+CG LPFD +P L
Sbjct: 167 FKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILR 226
Query: 250 KKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP---KYLFPED 306
+++ +G F P +++ L++ ML +DP KR TI I+EH+W ++P L+P++
Sbjct: 227 QRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQE 286
Query: 307 PSYSSTMID-DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIID 355
++ + +E + + +++ + L N+++ + A Y L+++
Sbjct: 287 QENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSY-NHFAAIYFLLVE 335
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 270 bits (691), Expect = 2e-72
Identities = 143/348 (41%), Positives = 212/348 (60%), Gaps = 22/348 (6%)
Query: 22 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKL 81
+++G Y + TLG G F VK+ +H +T +VA+KI+++ ++ S ++ KI RE+Q +KL
Sbjct: 22 LRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE-KIYREVQLMKL 80
Query: 82 FRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKE 141
HPHIIKLYQV+ T +++V E+ GE+FDY+ NG L E E
Sbjct: 81 LNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH---------------LSENE 125
Query: 142 SRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCG 201
+R+ F QILS V+YCH H +VHRDLK EN+LLD +M+ K+ADFG N GE L T CG
Sbjct: 126 ARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCG 185
Query: 202 SPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ 261
SP YAAPEV G+ Y GP++DIWS GV+LY L+CG+LPFD ++PTL +++ +G F P
Sbjct: 186 SPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPF 245
Query: 262 YLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD--LPKYLFP--EDPSYSSTMID-D 316
+++ SL++ ML VDP +R TI IR+H W + + LP P SY+S + D D
Sbjct: 246 FMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYD 305
Query: 317 EALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAK 364
E + + + + L N ++ + A Y+L+++ + A+
Sbjct: 306 EQALGIMQTLGVDRQRTVESLQNSSY-NHFAAIYYLLLERLKEYRNAQ 352
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 266 bits (680), Expect = 4e-71
Identities = 150/382 (39%), Positives = 221/382 (57%), Gaps = 31/382 (8%)
Query: 24 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 83
+G Y L TLG G G VK+G H +TG KVA+KI+NR+K+ S V+ K+ REI LKL
Sbjct: 31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 89
Query: 84 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESR 143
HPH++KL+ V +++V+E+VSGGELFDY+ K GR L KE+R
Sbjct: 90 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR---------------LTPKEAR 134
Query: 144 RLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP 203
+ F+QI+S +D+CH + + HRDLKPEN+LLD N +IADFG++++ L TSCGSP
Sbjct: 135 KFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSP 194
Query: 204 NYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL 263
+YA PEVI G Y G D+WS GVIL+ALL G LPFDDD++ L +K+ G+F+ P ++
Sbjct: 195 HYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFI 254
Query: 264 NPSVISLLKHMLQVDPMKRATIKDIREHEWF---KQDLPKYLFPEDPSY-------SSTM 313
P SLL+ M++V+P KR +++ I++H W+ K + L P S+
Sbjct: 255 PPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGE 314
Query: 314 IDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLA---- 369
+D + L+ + + E L ++ + Y+L++D + +D L
Sbjct: 315 LDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRND 374
Query: 370 TSPPDSFLDDHHLTRPHPERVP 391
PP +D L+R H +R P
Sbjct: 375 VDPPRKRVDSPMLSR-HGKRRP 395
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 266 bits (679), Expect = 5e-71
Identities = 155/383 (40%), Positives = 220/383 (57%), Gaps = 35/383 (9%)
Query: 24 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 83
+G Y L TLG G G VK+G H +T KVA+KI+NR+K+ S V+ K+ REI LKL
Sbjct: 16 VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 74
Query: 84 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESR 143
HPH++KL+ V +++V+E+VSGGELFDY+ K GR L KE+R
Sbjct: 75 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR---------------LTPKEAR 119
Query: 144 RLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP 203
+ F+QI+S +D+CH H + HRDLKPEN+LLD N +IADFG++++ L TSCGSP
Sbjct: 120 KFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSP 179
Query: 204 NYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL 263
+YA PEVI G Y G + D+WS GVIL+ALL G LPFDDD++ L +K+ G+F+ P ++
Sbjct: 180 HYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFI 239
Query: 264 NPSVISLLKHMLQVDPMKRATIKDIREHEWF--KQDLPKYLFPEDPSYSSTMIDDEALKE 321
P SLL+ M++VD +R T++ I++H W+ ++ P+ PE P I E
Sbjct: 240 PPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPE---PEQPIPRKVQIRSLPSLE 296
Query: 322 VCEKFECSEEEVLSCLYNRNH--QDPLA-------VAYHLIIDNRRIMNEAKDFYL---- 368
+ L C +RN QD L+ + Y L++D + +D L
Sbjct: 297 DIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRN 356
Query: 369 ATSPPDSFLDDHHLTRPHPERVP 391
PP +D L R H +R P
Sbjct: 357 EIDPPRKRVDSPMLNR-HGKRRP 378
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 257 bits (656), Expect = 2e-68
Identities = 153/404 (37%), Positives = 228/404 (56%), Gaps = 38/404 (9%)
Query: 12 TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
+A++Q H IG+Y L T+G G F KVK+ +H LTG +VAVKI+++ ++ S + K
Sbjct: 43 SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96
Query: 72 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKT 131
+ RE++ +K+ HP+I+KL++VI T +++VMEY SGGE+FDY+ +GR
Sbjct: 97 LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR---------- 146
Query: 132 GSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 191
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA MN KIADFG SN +
Sbjct: 147 -----MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT 201
Query: 192 DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKK 251
G L T CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L ++
Sbjct: 202 FGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER 261
Query: 252 ICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 306
+ G + P Y++ +LLK L ++P KR T++ I + W +L Y+ P
Sbjct: 262 VLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL- 320
Query: 307 PSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366
P Y D E+ + EE+ L + + + +A +L++ + E
Sbjct: 321 PDYK-----DPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTI 373
Query: 367 YLATSPPDSFLDDHHLTRPHP-ERVPFLVAETPRARHTLDELNP 409
L P D + + P P +V V+ P+ R D+ P
Sbjct: 374 TLKPRPS---ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGP 414
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 257 bits (656), Expect = 2e-68
Identities = 153/404 (37%), Positives = 228/404 (56%), Gaps = 38/404 (9%)
Query: 12 TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
+A++Q H IG+Y L T+G G F KVK+ +H LTG +VAVKI+++ ++ S + K
Sbjct: 43 SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96
Query: 72 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKT 131
+ RE++ +K+ HP+I+KL++VI T +++VMEY SGGE+FDY+ +GR
Sbjct: 97 LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR---------- 146
Query: 132 GSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 191
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA MN KIADFG SN +
Sbjct: 147 -----MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT 201
Query: 192 DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKK 251
G L T CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L ++
Sbjct: 202 FGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER 261
Query: 252 ICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 306
+ G + P Y++ +LLK L ++P KR T++ I + W +L Y+ P
Sbjct: 262 VLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL- 320
Query: 307 PSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366
P Y D E+ + EE+ L + + + +A +L++ + E
Sbjct: 321 PDYK-----DPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTI 373
Query: 367 YLATSPPDSFLDDHHLTRPHP-ERVPFLVAETPRARHTLDELNP 409
L P D + + P P +V V+ P+ R D+ P
Sbjct: 374 TLKPRPS---ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGP 414
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 257 bits (656), Expect = 2e-68
Identities = 153/404 (37%), Positives = 228/404 (56%), Gaps = 38/404 (9%)
Query: 12 TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
+A++Q H IG+Y L T+G G F KVK+ +H LTG +VAVKI+++ ++ S + K
Sbjct: 10 SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 63
Query: 72 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKT 131
+ RE++ +K+ HP+I+KL++VI T +++VMEY SGGE+FDY+ +GR
Sbjct: 64 LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR---------- 113
Query: 132 GSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 191
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA MN KIADFG SN +
Sbjct: 114 -----MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT 168
Query: 192 DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKK 251
G L T CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L ++
Sbjct: 169 FGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER 228
Query: 252 ICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 306
+ G + P Y++ +LLK L ++P KR T++ I + W +L Y+ P
Sbjct: 229 VLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL- 287
Query: 307 PSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366
P Y D E+ + EE+ L + + + +A +L++ + E
Sbjct: 288 PDYK-----DPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTI 340
Query: 367 YLATSPPDSFLDDHHLTRPHP-ERVPFLVAETPRARHTLDELNP 409
L P D + + P P +V V+ P+ R D+ P
Sbjct: 341 TLKPRPS---ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAGP 381
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 256 bits (653), Expect = 5e-68
Identities = 146/401 (36%), Positives = 229/401 (57%), Gaps = 34/401 (8%)
Query: 19 DGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQN 78
D + IG+Y L T+G G F KVK+ +H LTG +VAVKI+++ ++ + K+ RE++
Sbjct: 52 DEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRI 110
Query: 79 LKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELD 138
+K+ HP+I+KL++VI T +++VMEY SGGE+FDY+ +GR +
Sbjct: 111 MKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR---------------MK 155
Query: 139 EKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT 198
EKE+R F+QI+S V YCH+ +VHRDLK EN+LLD MN KIADFG SN + G L T
Sbjct: 156 EKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDT 215
Query: 199 SCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFY 258
CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L +++ G +
Sbjct: 216 FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR 275
Query: 259 TPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDPSYSSTM 313
P Y++ +LLK +L ++P+KR +++ I + W +++L Y P DP ++ T
Sbjct: 276 IPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEP-DPDFNDTK 334
Query: 314 IDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLA---- 369
D + + +E+ L N+ + + +A ++++ + E + +
Sbjct: 335 RID-----IMVTMGFARDEINDALINQKYDEVMAT--YILLGRKPPEFEGGESLSSGNLC 387
Query: 370 -TSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP 409
S P S L++ L P +V ++ + R D P
Sbjct: 388 QRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGP 428
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 256 bits (653), Expect = 5e-68
Identities = 151/408 (37%), Positives = 230/408 (56%), Gaps = 41/408 (10%)
Query: 13 AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72
A++Q H IG+Y L T+G G F KVK+ +H LTG +VA+KI+++ ++ + K+
Sbjct: 47 ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100
Query: 73 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTG 132
RE++ +K+ HP+I+KL++VI T ++++MEY SGGE+FDY+ +GR
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR----------- 149
Query: 133 STKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 192
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA MN KIADFG SN +
Sbjct: 150 ----MKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTV 205
Query: 193 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 252
G L T CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L +++
Sbjct: 206 GGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 265
Query: 253 CDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDP 307
G + P Y++ +LLK L ++P+KR T++ I + W + +L ++ PE
Sbjct: 266 LRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPE-- 323
Query: 308 SYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKD-- 365
I D+ ++ S+EE+ L + + A +L++ + +A D
Sbjct: 324 ----LDISDQKRIDIMVGMGYSQEEIQESLSKMKYDE--ITATYLLLGRKSSELDASDSS 377
Query: 366 ----FYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP 409
LA P S L++ PH +V V + + R D P
Sbjct: 378 SSSNLSLAKVRPSSDLNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGP 424
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 256 bits (653), Expect = 5e-68
Identities = 151/408 (37%), Positives = 230/408 (56%), Gaps = 41/408 (10%)
Query: 13 AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72
A++Q H IG+Y L T+G G F KVK+ +H LTG +VA+KI+++ ++ + K+
Sbjct: 47 ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100
Query: 73 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTG 132
RE++ +K+ HP+I+KL++VI T ++++MEY SGGE+FDY+ +GR
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR----------- 149
Query: 133 STKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 192
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA MN KIADFG SN +
Sbjct: 150 ----MKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTV 205
Query: 193 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 252
G L T CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L +++
Sbjct: 206 GGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 265
Query: 253 CDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDP 307
G + P Y++ +LLK L ++P+KR T++ I + W + +L ++ PE
Sbjct: 266 LRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPE-- 323
Query: 308 SYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKD-- 365
I D+ ++ S+EE+ L + + A +L++ + +A D
Sbjct: 324 ----LDISDQKRIDIMVGMGYSQEEIQESLSKMKYDE--ITATYLLLGRKSSELDASDSS 377
Query: 366 ----FYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP 409
LA P S L++ PH +V V + + R D P
Sbjct: 378 SSSNLSLAKVRPSSDLNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGP 424
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 256 bits (653), Expect = 5e-68
Identities = 151/408 (37%), Positives = 230/408 (56%), Gaps = 41/408 (10%)
Query: 13 AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72
A++Q H IG+Y L T+G G F KVK+ +H LTG +VA+KI+++ ++ + K+
Sbjct: 47 ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100
Query: 73 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTG 132
RE++ +K+ HP+I+KL++VI T ++++MEY SGGE+FDY+ +GR
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR----------- 149
Query: 133 STKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 192
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA MN KIADFG SN +
Sbjct: 150 ----MKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTV 205
Query: 193 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 252
G L T CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L +++
Sbjct: 206 GGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 265
Query: 253 CDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDP 307
G + P Y++ +LLK L ++P+KR T++ I + W + +L ++ PE
Sbjct: 266 LRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPE-- 323
Query: 308 SYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKD-- 365
I D+ ++ S+EE+ L + + A +L++ + +A D
Sbjct: 324 ----LDISDQKRIDIMVGMGYSQEEIQESLSKMKYDE--ITATYLLLGRKSSELDASDSS 377
Query: 366 ----FYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP 409
LA P S L++ PH +V V + + R D P
Sbjct: 378 SSSNLSLAKVRPSSDLNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGP 424
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 255 bits (651), Expect = 9e-68
Identities = 132/313 (42%), Positives = 199/313 (63%), Gaps = 22/313 (7%)
Query: 23 KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 82
+IG+Y + T+G G F VK H +T KVA+KI+++ ++ + + KI RE+Q +K+
Sbjct: 4 RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDE-ENLKKIFREVQIMKML 62
Query: 83 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKES 142
HPHII+LYQV+ T I++V EY SGGE+FD++ +GR + EKE+
Sbjct: 63 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMA---------------EKEA 107
Query: 143 RRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS 202
RR F+QI++ V +CH +VHRDLK EN+LLDA++N KIADFG SN+ + G+ L+T CGS
Sbjct: 108 RRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGS 167
Query: 203 PNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQY 262
P YAAPE+ G+ Y GP+VDIWS GV+LY L+CG LPFD + L ++ G F P +
Sbjct: 168 PPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFF 227
Query: 263 LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEV 322
++ L++HML +DP KR +++ I +H+W K L DP++ + + + LKE
Sbjct: 228 MSTECEHLIRHMLVLDPNKRLSMEQICKHKWMK------LGDADPNFDRLIAECQQLKEE 281
Query: 323 CEKFECSEEEVLS 335
+ +E+ +L+
Sbjct: 282 RQVDPLNEDVLLA 294
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 254 bits (650), Expect = 1e-67
Identities = 152/401 (37%), Positives = 227/401 (56%), Gaps = 38/401 (9%)
Query: 12 TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
+A++Q H IG+Y L T+G G F KVK+ +H LTG +VAVKI+++ ++ S + K
Sbjct: 43 SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96
Query: 72 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKT 131
+ RE++ +K+ HP+I+KL++VI T +++VMEY SGGE+FDY+ +GR
Sbjct: 97 LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR---------- 146
Query: 132 GSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 191
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA MN KIADFG SN +
Sbjct: 147 -----MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT 201
Query: 192 DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKK 251
G L T CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L ++
Sbjct: 202 FGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER 261
Query: 252 ICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 306
+ G + P Y++ +LLK L ++P KR T++ I + W +L Y+ P
Sbjct: 262 VLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL- 320
Query: 307 PSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366
P Y D E+ + EE+ L + + + +A +L++ + E
Sbjct: 321 PDYK-----DPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTI 373
Query: 367 YLATSPPDSFLDDHHLTRPHP-ERVPFLVAETPRARHTLDE 406
L P D + + P P +V V+ P+ R D+
Sbjct: 374 TLKPRPS---ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ 411
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 254 bits (650), Expect = 1e-67
Identities = 152/401 (37%), Positives = 227/401 (56%), Gaps = 38/401 (9%)
Query: 12 TAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 71
+A++Q H IG+Y L T+G G F KVK+ +H LTG +VAVKI+++ ++ S + K
Sbjct: 43 SADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-K 96
Query: 72 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKT 131
+ RE++ +K+ HP+I+KL++VI T +++VMEY SGGE+FDY+ +GR
Sbjct: 97 LFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR---------- 146
Query: 132 GSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 191
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA MN KIADFG SN +
Sbjct: 147 -----MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT 201
Query: 192 DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKK 251
G L T CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L ++
Sbjct: 202 FGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER 261
Query: 252 ICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 306
+ G + P Y++ +LLK L ++P KR T++ I + W +L Y+ P
Sbjct: 262 VLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL- 320
Query: 307 PSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366
P Y D E+ + EE+ L + + + +A +L++ + E
Sbjct: 321 PDYK-----DPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT--YLLLGYKSSELEGDTI 373
Query: 367 YLATSPPDSFLDDHHLTRPHP-ERVPFLVAETPRARHTLDE 406
L P D + + P P +V V+ P+ R D+
Sbjct: 374 TLKPRPS---ADLTNSSAPSPSHKVQRSVSANPKQRRFSDQ 411
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 253 bits (645), Expect = 4e-67
Identities = 138/346 (39%), Positives = 209/346 (60%), Gaps = 33/346 (9%)
Query: 13 AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72
A++Q H IG+Y L T+G G F KVK+ +H LTG +VA+KI+++ ++ + K+
Sbjct: 47 ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100
Query: 73 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTG 132
RE++ +K+ HP+I+KL++VI T ++++MEY SGGE+FDY+ +GR
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR----------- 149
Query: 133 STKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 192
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA MN KIADFG SN +
Sbjct: 150 ----MKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTV 205
Query: 193 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 252
G L T CGSP YAAPE+ G+ Y GPEVD+WS GVILY L+ G+LPFD ++ L +++
Sbjct: 206 GGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 265
Query: 253 CDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDP 307
G + P Y++ +LLK L ++P+KR T++ I + W + +L ++ PE
Sbjct: 266 LRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPE-- 323
Query: 308 SYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLI 353
I D+ ++ S+EE+ L ++ D + Y L+
Sbjct: 324 ----LDISDQKRIDIMVGMGYSQEEIQESL-SKMKYDEITATYLLL 364
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 245 bits (625), Expect = 9e-65
Identities = 139/333 (41%), Positives = 195/333 (58%), Gaps = 25/333 (7%)
Query: 26 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 85
+Y L +T+G G F KVK+ H LTG VA+KI+++ + S + +I+ EI+ LK RH
Sbjct: 10 YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLRHQ 67
Query: 86 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRL 145
HI +LY V+ T + IFMV+EY GGELFDYI R L E+E+R +
Sbjct: 68 HICQLYHVLETANKIFMVLEYCPGGELFDYIISQDR---------------LSEEETRVV 112
Query: 146 FQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE--FLRTSCGSP 203
F+QI+S V Y H HRDLKPEN+L D + K+ DFGL + L+T CGS
Sbjct: 113 FRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSL 172
Query: 204 NYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL 263
YAAPE+I G+ Y G E D+WS G++LY L+CG LPFDDD+V L+KKI G + P++L
Sbjct: 173 AYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWL 232
Query: 264 NPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMI--DDEALKE 321
+PS I LL+ MLQVDP KR ++K++ H W QD Y +P + + I DD+ + E
Sbjct: 233 SPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD---YNYPVEWQSKNPFIHLDDDCVTE 289
Query: 322 VCEKFECSEEEVLSCLYNRNHQDPLAVAYHLII 354
+ + + + L + D L Y L++
Sbjct: 290 LSVHHR-NNRQTMEDLISLWQYDHLTATYLLLL 321
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 244 bits (623), Expect = 2e-64
Identities = 128/298 (42%), Positives = 187/298 (62%), Gaps = 26/298 (8%)
Query: 14 EKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIR 73
E+Q H +G+Y L T+G G F KVK+ +H LTG +VA+KI+++ ++ + K+
Sbjct: 51 EEQPH-----VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLF 104
Query: 74 REIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGS 133
RE++ +K HP+I+KL++VI T +++VMEY S GE+FDY+ +GR
Sbjct: 105 REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR------------ 152
Query: 134 TKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG 193
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA N KIADFG SN + G
Sbjct: 153 ---MKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLG 209
Query: 194 EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKIC 253
L T CGSP YAAPE+ G+ Y GPEVDIWS GVILY L+ G+LPFD ++ L +++
Sbjct: 210 SKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVL 269
Query: 254 DGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 306
G + P Y++ S+L+ L ++P KR T++ I + +W ++L Y PE+
Sbjct: 270 RGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEE 327
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 237 bits (604), Expect = 2e-62
Identities = 135/330 (40%), Positives = 192/330 (58%), Gaps = 37/330 (11%)
Query: 16 QKHDGRVKIGH-YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
++H + + H Y L +TLG GT+GKVK +G VA+K + + KI+ + IRR
Sbjct: 43 KRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRR 102
Query: 75 EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGST 134
EI+ + HPHII +Y+V I ++MEY S GEL+DYI + R
Sbjct: 103 EIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRR------------- 149
Query: 135 KELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE 194
L E+E+R F+QI+S V YCH++ VVHRDLK EN+LLD + N KIADFGLSN+ +
Sbjct: 150 --LSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDK 207
Query: 195 FLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICD 254
FL+T CGSP YA+PE+++GR Y GPEVD W+ GV+LY L+ GT+PFD L ++I
Sbjct: 208 FLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISS 267
Query: 255 GIFYTPQYLNPS-VISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTM 313
G + P PS L++ ML V+P +RATI+DI H W Y S++
Sbjct: 268 GEYREP--TQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNW-----------GYKSSV 314
Query: 314 IDDEALKEVCEKFECSEEEVLSCLYNRNHQ 343
D +AL + SE +L+ + + +H+
Sbjct: 315 CDCDALHD-------SESPLLARIIDWHHR 337
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 236 bits (601), Expect = 6e-62
Identities = 125/280 (44%), Positives = 179/280 (63%), Gaps = 20/280 (7%)
Query: 16 QKHDGRVKIGH-YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
++H + + H Y +TLG GT+GKVK + E +G VA+K + + KI+ + IRR
Sbjct: 41 KRHHHKHNLRHRYEFLETLGKGTYGKVKKAR-ESSGRLVAIKSIRKDKIKDEQDLMHIRR 99
Query: 75 EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGST 134
EI+ + HPHII +++V S I +VMEY S G+L+DYI +
Sbjct: 100 EIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISER--------------- 144
Query: 135 KELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE 194
++L E+E+R F+QI+S V YCH++ VVHRDLK EN+LLDA+ N KIADFGLSN+ G+
Sbjct: 145 QQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGK 204
Query: 195 FLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICD 254
FL+T CGSP YA+PE+++G+ Y GPEVD WS GV+LY L+ GT+PFD L K+I +
Sbjct: 205 FLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISN 264
Query: 255 GIFYTPQYLNPS-VISLLKHMLQVDPMKRATIKDIREHEW 293
G + P PS L++ +L V+P +RAT++D+ H W
Sbjct: 265 GAYREPP--KPSDACGLIRWLLMVNPTRRATLEDVASHWW 302
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 211 bits (538), Expect = 1e-54
Identities = 123/364 (33%), Positives = 201/364 (55%), Gaps = 29/364 (7%)
Query: 15 KQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
K+ +DG++ G Y L TLG G F VK+ +H TG KVAVK++++ K+ +L G + +
Sbjct: 5 KRGYDGKIA-GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQ 62
Query: 75 EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGST 134
E++ +KL +HP+I++LY+VI T + +++++E GG++FDYI K+
Sbjct: 63 EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKH--------------E 108
Query: 135 KELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDG 193
+ L+E +++ F QI+ + YCH+ VVHRDLKPENV+ K+ DFG SN G
Sbjct: 109 EGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPG 168
Query: 194 EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKIC 253
+ L TSCGS Y+APE++ G Y P VDIWS GVIL+ L+CG PF + + I
Sbjct: 169 KKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIM 228
Query: 254 DGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP----KYLFPEDPSY 309
D + P +++ L+ MLQ DP +RA++++I H W + P KY P
Sbjct: 229 DCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKY---NIPLV 285
Query: 310 SSTMIDDEALKEVCEKF---ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366
S + +E + ++ + ++ + + N + + Y L+ + RI+ E ++
Sbjct: 286 SYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAE--RILREKQEK 343
Query: 367 YLAT 370
+ T
Sbjct: 344 EIQT 347
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 211 bits (538), Expect = 1e-54
Identities = 123/364 (33%), Positives = 201/364 (55%), Gaps = 29/364 (7%)
Query: 15 KQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
K+ +DG++ G Y L TLG G F VK+ +H TG KVAVK++++ K+ +L G + +
Sbjct: 5 KRGYDGKIA-GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQ 62
Query: 75 EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGST 134
E++ +KL +HP+I++LY+VI T + +++++E GG++FDYI K+
Sbjct: 63 EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKH--------------E 108
Query: 135 KELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDG 193
+ L+E +++ F QI+ + YCH+ VVHRDLKPENV+ K+ DFG SN G
Sbjct: 109 EGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPG 168
Query: 194 EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKIC 253
+ L TSCGS Y+APE++ G Y P VDIWS GVIL+ L+CG PF + + I
Sbjct: 169 KKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIM 228
Query: 254 DGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP----KYLFPEDPSY 309
D + P +++ L+ MLQ DP +RA++++I H W + P KY P
Sbjct: 229 DCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKY---NIPLV 285
Query: 310 SSTMIDDEALKEVCEKF---ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 366
S + +E + ++ + ++ + + N + + Y L+ + RI+ E ++
Sbjct: 286 SYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAE--RILREKQEK 343
Query: 367 YLAT 370
+ T
Sbjct: 344 EIQT 347
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 202 bits (515), Expect = 5e-52
Identities = 122/339 (35%), Positives = 183/339 (53%), Gaps = 24/339 (7%)
Query: 23 KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 82
+IG Y + +G G F +VK+G H LT KVA+KIL++ K+ + REI +++
Sbjct: 70 RIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQ-KTQRLLSREISSMEKL 128
Query: 83 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKES 142
HP+II+LY+V+ T S + +VMEY GGELF I G+ L E ES
Sbjct: 129 HHPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGK---------------LSEPES 173
Query: 143 RRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS 202
+ +F QI+S V + H + ++HRDLK ENV ++ K+ DFG S + GE L T CGS
Sbjct: 174 KLIFSQIVSAVKHMHENQIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGS 233
Query: 203 PNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQY 262
P YAAPE+ Y G VDIW+ GV+LY ++ GT+PF + V L K I +G + P +
Sbjct: 234 PPYAAPELFRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPH 293
Query: 263 LNPSVISLLKHMLQVDPMKRATIKDIREHEWFK---QDLPKYLFPEDP---SYSSTMIDD 316
++ L++ +LQ P +R I I EW + P F DP S +ST+ ++
Sbjct: 294 VSEPCHRLIRGVLQQIPTERYGIDCIMNDEWMQGVPYPTPLEPFQLDPKHLSETSTLKEE 353
Query: 317 E-ALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLII 354
E +K E +EE + + R+ + + Y +I+
Sbjct: 354 ENEVKSTLEHLGITEEHIRN-NQGRDARSSITGVYRIIL 391
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 192 bits (487), Expect = 9e-49
Identities = 109/283 (38%), Positives = 171/283 (60%), Gaps = 24/283 (8%)
Query: 23 KIGHYILGDT-LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK-IRREIQNLK 80
++G+Y++G LG G+F KV+ G H LTG KVA+K++++++ + V K +RRE Q +
Sbjct: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
Query: 81 LFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEK 140
+ RHP+I +L ++ T + ++VME GG L I + K L+E
Sbjct: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEK---------------KRLEES 161
Query: 141 ESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLR 197
E+RR +Q++S V++ HR VVHRDLK EN+LLD N K+ DFGLSN ++ +
Sbjct: 162 EARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFS 221
Query: 198 TSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF--DDDHVPTLFKKICD- 254
T CGSP YAAPE+++ + Y GP++D+WS GV +YA+L GTLPF + + L++K+ D
Sbjct: 222 TQCGSPAYAAPELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDK 280
Query: 255 GIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD 297
+ P L+ IS L+ +L+ DP+KR I+ + W ++
Sbjct: 281 EMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNEN 323
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 172 bits (435), Expect = 1e-42
Identities = 104/300 (34%), Positives = 163/300 (54%), Gaps = 34/300 (11%)
Query: 5 SSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIR 64
SSW+K A K+ + + +TLG G F +V + + + TG AVK + ++ ++
Sbjct: 10 SSWKKQAEDIKKIFEFK---------ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 60
Query: 65 SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSD 124
+ I EI L+ +H +I+ L + +P+ +++VM+ VSGGELFD I + G +
Sbjct: 61 GKE--SSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYT- 117
Query: 125 VPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL---DAHMNAKI 181
EK++ L +Q+L V Y HR +VHRDLKPEN+L D I
Sbjct: 118 --------------EKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMI 163
Query: 182 ADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFD 241
+DFGLS M G+ + T+CG+P Y APEV++ + Y+ VD WS GVI Y LLCG PF
Sbjct: 164 SDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYS-KAVDCWSIGVIAYILLCGYPPFY 222
Query: 242 DDHVPTLFKKI--CDGIFYTPQY--LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD 297
D++ LF++I + F +P + ++ S ++++++ DP KR T + H W D
Sbjct: 223 DENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGD 282
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 172 bits (435), Expect = 1e-42
Identities = 104/300 (34%), Positives = 163/300 (54%), Gaps = 34/300 (11%)
Query: 5 SSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIR 64
SSW+K A K+ + + +TLG G F +V + + + TG AVK + ++ ++
Sbjct: 10 SSWKKQAEDIKKIFEFK---------ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 60
Query: 65 SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSD 124
+ I EI L+ +H +I+ L + +P+ +++VM+ VSGGELFD I + G +
Sbjct: 61 GKE--SSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYT- 117
Query: 125 VPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL---DAHMNAKI 181
EK++ L +Q+L V Y HR +VHRDLKPEN+L D I
Sbjct: 118 --------------EKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMI 163
Query: 182 ADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFD 241
+DFGLS M G+ + T+CG+P Y APEV++ + Y+ VD WS GVI Y LLCG PF
Sbjct: 164 SDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYS-KAVDCWSIGVIAYILLCGYPPFY 222
Query: 242 DDHVPTLFKKI--CDGIFYTPQY--LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD 297
D++ LF++I + F +P + ++ S ++++++ DP KR T + H W D
Sbjct: 223 DENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGD 282
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 167 bits (422), Expect = 3e-41
Identities = 99/278 (35%), Positives = 151/278 (54%), Gaps = 25/278 (8%)
Query: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
Y D LG G F +V + + + T VA+K + ++ + + G + EI L +HP+
Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE--GSMENEIAVLHKIKHPN 77
Query: 87 IIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLF 146
I+ L + + ++++M+ VSGGELFD I + G + E+++ RL
Sbjct: 78 IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYT---------------ERDASRLI 122
Query: 147 QQILSGVDYCHRHMVVHRDLKPENVL---LDAHMNAKIADFGLSNMMSDGEFLRTSCGSP 203
Q+L V Y H +VHRDLKPEN+L LD I+DFGLS M G L T+CG+P
Sbjct: 123 FQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTP 182
Query: 204 NYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI--CDGIFYTPQ 261
Y APEV++ + Y+ VD WS GVI Y LLCG PF D++ LF++I + F +P
Sbjct: 183 GYVAPEVLAQKPYS-KAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPY 241
Query: 262 Y--LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD 297
+ ++ S ++H+++ DP KR T + +H W D
Sbjct: 242 WDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGD 279
>gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]
Length = 433
Score = 164 bits (416), Expect = 2e-40
Identities = 99/283 (34%), Positives = 159/283 (56%), Gaps = 21/283 (7%)
Query: 24 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSL-DVVGKIRREIQNLKLF 82
IG Y++GD LG G++GKVK T + AVKIL ++K+R + + +++EIQ L+
Sbjct: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
Query: 83 RHPHIIKLYQVI--STPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEK 140
RH ++I+L V+ ++MVMEY C G + + V + K
Sbjct: 106 RHKNVIQLVDVLYNEEKQKMYMVMEY----------CVCGMQEMLDSVPE----KRFPVC 151
Query: 141 ESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLR 197
++ F Q++ G++Y H +VH+D+KP N+LL KI+D G++ + + + R
Sbjct: 152 QAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCR 211
Query: 198 TSCGSPNYAAPEVISGR-LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI 256
TS GSP + PE+ +G ++G +VDIWS+GV LY + G PF+ D++ LF+ I G
Sbjct: 212 TSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGS 271
Query: 257 FYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP 299
+ P P + LLK ML+ +P KR +I+ IR+H WF++ P
Sbjct: 272 YAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 314
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,795,908
Number of Sequences: 37866
Number of extensions: 1035491
Number of successful extensions: 5276
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 726
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 2667
Number of HSP's gapped (non-prelim): 1013
length of query: 574
length of database: 18,247,518
effective HSP length: 108
effective length of query: 466
effective length of database: 14,157,990
effective search space: 6597623340
effective search space used: 6597623340
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.