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Search of human proteins with 94536840
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94536840 transmembrane and coiled-coil domains 6 [Homo
sapiens]
(493 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens] 958 0.0
gi|224589129 karyopherin 7 [Homo sapiens] 65 1e-10
gi|6912478 karyopherin alpha 6 [Homo sapiens] 61 2e-09
gi|39812229 karyopherin alpha 5 [Homo sapiens] 59 1e-08
gi|4504897 karyopherin alpha 2 [Homo sapiens] 56 7e-08
gi|4504901 karyopherin alpha 4 [Homo sapiens] 52 2e-06
gi|222144293 karyopherin alpha 1 [Homo sapiens] 50 6e-06
gi|34485722 karyopherin alpha 3 [Homo sapiens] 50 6e-06
gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens] 44 3e-04
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [... 42 0.002
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [... 42 0.002
gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens] 41 0.002
gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens] 41 0.002
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [... 39 0.008
gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [... 39 0.008
gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [... 39 0.008
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 38 0.018
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] 37 0.041
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] 37 0.041
gi|194294548 hsp70-interacting protein [Homo sapiens] 37 0.054
gi|112363070 hsp70-interacting protein [Homo sapiens] 37 0.054
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa... 36 0.091
gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo sa... 35 0.12
gi|148746195 trichohyalin [Homo sapiens] 35 0.16
gi|55742693 zyg-11 homolog B [Homo sapiens] 34 0.27
gi|8922873 GTPase, IMAP family member 4 [Homo sapiens] 34 0.35
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 33 0.45
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 33 0.45
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 33 0.45
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 33 0.45
>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
Length = 493
Score = 958 bits (2477), Expect = 0.0
Identities = 493/493 (100%), Positives = 493/493 (100%)
Query: 1 MWSRRQGRLRPTVCGVEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAA 60
MWSRRQGRLRPTVCGVEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAA
Sbjct: 1 MWSRRQGRLRPTVCGVEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAA 60
Query: 61 ILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSN 120
ILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSN
Sbjct: 61 ILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSN 120
Query: 121 QALLQLEAARCLHELSHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVES 180
QALLQLEAARCLHELSHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVES
Sbjct: 121 QALLQLEAARCLHELSHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVES 180
Query: 181 EAVRRQLLPQGIVPALAACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQH 240
EAVRRQLLPQGIVPALAACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQH
Sbjct: 181 EAVRRQLLPQGIVPALAACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQH 240
Query: 241 MLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSNPLLIGHGALSTLGLLLLDLAGAVQKTE 300
MLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSNPLLIGHGALSTLGLLLLDLAGAVQKTE
Sbjct: 241 MLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSNPLLIGHGALSTLGLLLLDLAGAVQKTE 300
Query: 301 DAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSLLPEG 360
DAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSLLPEG
Sbjct: 301 DAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSLLPEG 360
Query: 361 LWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNVVSVMVLTVLCNVAEKGPAYCQRLW 420
LWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNVVSVMVLTVLCNVAEKGPAYCQRLW
Sbjct: 361 LWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNVVSVMVLTVLCNVAEKGPAYCQRLW 420
Query: 421 PGPLLPALLHTLAFSDTEVVGQSLELLHLLFLYQPEAVQVFLQQSGLQALERHQEEAQLQ 480
PGPLLPALLHTLAFSDTEVVGQSLELLHLLFLYQPEAVQVFLQQSGLQALERHQEEAQLQ
Sbjct: 421 PGPLLPALLHTLAFSDTEVVGQSLELLHLLFLYQPEAVQVFLQQSGLQALERHQEEAQLQ 480
Query: 481 DRVYALQQTALQG 493
DRVYALQQTALQG
Sbjct: 481 DRVYALQQTALQG 493
>gi|224589129 karyopherin 7 [Homo sapiens]
Length = 516
Score = 65.5 bits (158), Expect = 1e-10
Identities = 98/409 (23%), Positives = 173/409 (42%), Gaps = 62/409 (15%)
Query: 11 PTVCGVEELRR-----------RRREREAA---LRKARREQQLVSKRLLRNDAPEEAGEG 56
PT+ EE RR RR++R A LRKA++++Q + +R + + P+ E
Sbjct: 2 PTLDAPEERRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEK 61
Query: 57 CVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSM--RTLV 114
+ + + ++ ++ A + R+ L + + +E + R +
Sbjct: 62 TAKGVAVSLTLGEIIKGVN-SSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVE 120
Query: 115 GLLTSNQALLQLEAARCLHEL-SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTL 173
L +S LQ EAA L + S + + T A A L+ LSS + E ++ L
Sbjct: 121 FLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWAL 180
Query: 174 GNLIVESEAVRRQLLPQGIVPALAACIQSPHVAV--LEALGYALSQLLQ------AEEAP 225
GN+ + R ++ +P L A I SP + + L + + LS L + + A
Sbjct: 181 GNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAV 239
Query: 226 EKIIPSILASTLPQHMLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSNPLL---IGHGAL 282
++I+P++L H+LQ + V + W L Y+ + SN + + G L
Sbjct: 240 KQILPALL------HLLQ------HQDSEVLSDACWALSYL--TDGSNKRIGQVVNTGVL 285
Query: 283 STLGLLLLDLAGAVQKTEDAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAAL 342
L +L+ + L +L P LR + N++T +T QM + L
Sbjct: 286 PRLVVLMTS----------SELNVLT-PSLRTVGNIVTGTDEQT---QMAID----AGML 327
Query: 343 FILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLL 391
+L Q +PS+ E W L+N+ A LL+ D++ PL+ LL
Sbjct: 328 NVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALL 376
Score = 41.2 bits (95), Expect = 0.002
Identities = 53/218 (24%), Positives = 86/218 (39%), Gaps = 21/218 (9%)
Query: 247 PGPKLNPGVAVEFAWCLHYIICS-QVSNPLLIGHGALSTLGLLLLDLAGAVQKTEDAGL- 304
P K GVAV L II S+P+L + +L + ++ +AGL
Sbjct: 58 PSEKTAKGVAVSLT--LGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLI 115
Query: 305 ----ELLACPVLRCLSNLLTEAAVETVGGQM-QLRDERVVAALFILLQFFFQKQPSLLPE 359
E L + CL A G Q R A+ L++ ++ +
Sbjct: 116 PRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQ 175
Query: 360 GLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNVVSVMVLTVLCNVAEKGPAYCQRL 419
+W L N+ + P F ++++ + I LL L+ + + +T L N+ C+
Sbjct: 176 AVWALGNIAGDGPEFRDNVITSNAIPHLLALISPT-----LPITFLRNITWTLSNLCRNK 230
Query: 420 WPGP-------LLPALLHTLAFSDTEVVGQSLELLHLL 450
P P +LPALLH L D+EV+ + L L
Sbjct: 231 NPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYL 268
Score = 37.4 bits (85), Expect = 0.031
Identities = 36/138 (26%), Positives = 60/138 (43%), Gaps = 5/138 (3%)
Query: 354 PSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNV-VSVMVLTVLCNVAEKG 412
P L E W L N+ + + +++ I+PL++LL SNV V + L N+A G
Sbjct: 128 PCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDG 187
Query: 413 PAYCQRLWPGPLLPALLHTLA--FSDTEVVGQSLELLHLLFLYQPEAVQVFLQQ--SGLQ 468
P + + +P LL ++ T + + L +L P ++Q L
Sbjct: 188 PEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALL 247
Query: 469 ALERHQEEAQLQDRVYAL 486
L +HQ+ L D +AL
Sbjct: 248 HLLQHQDSEVLSDACWAL 265
>gi|6912478 karyopherin alpha 6 [Homo sapiens]
Length = 536
Score = 61.2 bits (147), Expect = 2e-09
Identities = 92/390 (23%), Positives = 159/390 (40%), Gaps = 42/390 (10%)
Query: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEA------GEGCVAAILGETEVQQF 70
EE+RRRR E LRK +REQQL +R + E A + V++ GE+ + +
Sbjct: 25 EEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITRE 84
Query: 71 LRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTL---VGLLTSNQ-ALLQL 126
+ + +++ + + A R L E + + R + V L N+ LQ
Sbjct: 85 MVE-MLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQF 143
Query: 127 EAARCLHEL-SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRR 185
EAA L + S + Q T A + L+S D E ++ LGN+ +S R
Sbjct: 144 EAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRD 203
Query: 186 QLLPQGIV-PALAACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQM 244
+L I+ P L +S + + +ALS L + + P + + ++ LP +
Sbjct: 204 YVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEF--AKVSPCLPVLSRLL 261
Query: 245 LQPGPKLNPGVAVEFAWCLHYIICSQVSN---PLLIGHGALSTLGLLLLDLAGAVQKTED 301
L + W L Y+ S N +I G L LL+ V
Sbjct: 262 FSSDSDL----LADACWALSYL--SDGPNEKIQAVIDSGVCRRLVELLMHNDYKV----- 310
Query: 302 AGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSLLPEGL 361
A P LR + N++T G +Q + +AL LL + S+ E
Sbjct: 311 ------ASPALRAVGNIVT-------GDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC 357
Query: 362 WLLNNLTANSPSFCTSLLSLDLIEPLLQLL 391
W ++N+TA + + +++ ++ L+++L
Sbjct: 358 WTISNITAGNRAQIQAVIDANIFPVLIEIL 387
>gi|39812229 karyopherin alpha 5 [Homo sapiens]
Length = 539
Score = 58.9 bits (141), Expect = 1e-08
Identities = 106/442 (23%), Positives = 169/442 (38%), Gaps = 57/442 (12%)
Query: 17 EELRRRRREREAALRKARREQQLVSKR---LLRNDAP------EEAGEGCVAAILGETEV 67
+E+RRRR E LRK +RE+QL +R L RND ++ I E V
Sbjct: 25 QEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDISSTVPIPEEEVV 84
Query: 68 QQFLRQAQRGTEEKEREGALVSLRRGLQ---HPETQQTFIRLEGSMRTLVGLLTSNQ-AL 123
+ Q ++ A R+ L +P Q I+ G ++ V L N+
Sbjct: 85 TTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQV-IQKPGVVQRFVKFLERNENCT 143
Query: 124 LQLEAARCLHEL-SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEA 182
LQ EAA L + S + T A + L+S D E ++ LGN+ ++
Sbjct: 144 LQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAE 203
Query: 183 VRRQLLPQGIVPALAACI-QSPHVAVLEALGYALSQLLQAEEAP---EKIIPSILASTLP 238
R +L I+P L + S + +ALS L + + P K+ P + + L
Sbjct: 204 CRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCL--NVLS 261
Query: 239 QHMLQMLQPGPKLNPGVAVEFAWCLHY-----------IICSQVSNPL--LIGHGALSTL 285
+ + +P V + W L Y +I S V L L+ H +
Sbjct: 262 RLLFSS-------DPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVV 314
Query: 286 GLLLLDLAGAVQKTEDAGLELLACPVLRCLSNLLTEAAVE------------TVGGQMQL 333
L + V + +L C L CL +LL+ T G + Q+
Sbjct: 315 SPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQI 374
Query: 334 RDERVVAALFILLQFFFQKQPSLLPEGLWLLNNLTA-NSPSFCTSLLSLDLIEPLLQLLP 392
+ +L++ + + E W + N T+ +P L++L I+PL LL
Sbjct: 375 QAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLT 434
Query: 393 V--SNVVSVMVLTVLCNVAEKG 412
V S +V V L L N+ G
Sbjct: 435 VMDSKIVQV-ALNGLENILRLG 455
>gi|4504897 karyopherin alpha 2 [Homo sapiens]
Length = 529
Score = 56.2 bits (134), Expect = 7e-08
Identities = 102/491 (20%), Positives = 198/491 (40%), Gaps = 64/491 (13%)
Query: 18 ELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQRG 77
E+RRRR E LRKA+++ Q++ +R + + P++A + V + +G
Sbjct: 26 EMRRRRIEVNVELRKAKKDDQMLKRRNV-SSFPDDATSPLQENRNNQGTVNWSVDDIVKG 84
Query: 78 TEEKEREGALVSLR--RGLQHPETQQTF--IRLEGSMRTLVGLL-TSNQALLQLEAARCL 132
E L + + R L E Q I G + V L ++ + +Q E+A L
Sbjct: 85 INSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWAL 144
Query: 133 HEL----SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLL 188
+ S ++ V +PA LL +H S E ++ LGN+ + R ++
Sbjct: 145 TNIASGTSEQTKAVVDGGAIPAFISLLASPHAHIS---EQAVWALGNIAGDGSVFRDLVI 201
Query: 189 PQGIVPALAACIQSPHVA-----VLEALGYALSQLLQAE------EAPEKIIPSILASTL 237
G V L A + P ++ L L + LS L + + +A E+I+P+++ L
Sbjct: 202 KYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLV--RL 259
Query: 238 PQHMLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSNPLLIGHGALSTLGLLLLDLAGAVQ 297
H +P V + W + Y+ IG + + L+ L GA +
Sbjct: 260 LHHD----------DPEVLADTCWAISYLTDGPNER---IGMVVKTGVVPQLVKLLGASE 306
Query: 298 KTEDAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSLL 357
+ P LR + N++T G Q + AL + + ++
Sbjct: 307 LP-------IVTPALRAIGNIVT-------GTDEQTQVVIDAGALAVFPSLLTNPKTNIQ 352
Query: 358 PEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNV-VSVMVLTVLCNVAEKGPA-Y 415
E W ++N+TA +++ L+ L+ +L ++ + + N G
Sbjct: 353 KEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQ 412
Query: 416 CQRLWPGPLLPALLHTLAFSDTEVVGQSLELLHLLF-----LYQPEAVQVFLQQSG---- 466
L ++ L++ L DT+++ L+ + +F L + E + + +++ G
Sbjct: 413 IVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDK 472
Query: 467 LQALERHQEEA 477
++AL+ H+ E+
Sbjct: 473 IEALQNHENES 483
>gi|4504901 karyopherin alpha 4 [Homo sapiens]
Length = 521
Score = 51.6 bits (122), Expect = 2e-06
Identities = 102/488 (20%), Positives = 187/488 (38%), Gaps = 65/488 (13%)
Query: 16 VEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQ 75
+E +RR+R E LRK +R++ L+ + RN E+ E + I G+ VQ +A
Sbjct: 22 LETMRRQRNEVVVELRKNKRDEHLLKR---RNVPHEDICED--SDIDGDYRVQNTSLEAI 76
Query: 76 RGTEEKEREG---ALVSLRRGLQHPETQQTFIRL--EGSMRTLVGLL-TSNQALLQLEAA 129
+ +G + V R L + L G + LV L + LQ EAA
Sbjct: 77 VQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAA 136
Query: 130 RCLHEL-SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLL 188
L + S + + T A A L L S + E ++ LGN+I + R ++
Sbjct: 137 WALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVI 196
Query: 189 PQGIV-PALAACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQMLQP 247
G+V P L+ S + L + + + L + ++ P P +Q + P
Sbjct: 197 SLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPP-----------PMETIQEILP 245
Query: 248 G-----PKLNPGVAVEFAWCLHYIICSQVSNPLLIGHGALSTLGLLLLDLAGAVQKTEDA 302
+ + V+ W L Y+ + N +Q D+
Sbjct: 246 ALCVLIHHTDVNILVDTVWALSYL--TDAGNE--------------------QIQMVIDS 283
Query: 303 GLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVA-----ALFILLQFFFQKQPSLL 357
G+ P+L + AA+ VG + DE+ AL + +
Sbjct: 284 GIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKIN 343
Query: 358 PEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNV-VSVMVLTVLCNVAEKG-PAY 415
E +W L+N+TA + +++ +L+ ++ LL + + N+ G
Sbjct: 344 KEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQ 403
Query: 416 CQRLWPGPLLPALLHTLAFSDTEVVGQSLE-LLHLLFLYQPEAVQV--FLQQSG----LQ 468
L ++P + L D +VV L+ L ++L + + EA + +++ G ++
Sbjct: 404 VAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIE 463
Query: 469 ALERHQEE 476
L+ H+ E
Sbjct: 464 QLQNHENE 471
>gi|222144293 karyopherin alpha 1 [Homo sapiens]
Length = 538
Score = 49.7 bits (117), Expect = 6e-06
Identities = 86/395 (21%), Positives = 145/395 (36%), Gaps = 47/395 (11%)
Query: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQR 76
+E+RRRR E LRK +RE+QL +R + E E E ++ + A
Sbjct: 22 DEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQISN-MEMAPG 80
Query: 77 GTEEKEREGALVSLRRGLQHPETQQ--------------TFIRLEGSMRTLVGLLTSNQ- 121
G + + S Q TQ+ I G + V L +
Sbjct: 81 GVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKEN 140
Query: 122 ALLQLEAARCLHEL-SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVES 180
LQ E+A L + S + T A + LSS D E ++ LGN+ +S
Sbjct: 141 CTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDS 200
Query: 181 EAVRRQLLPQGIVPALAACIQSPH-VAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQ 239
R +L I+P L + + + +ALS L + + P + +
Sbjct: 201 TMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLS 260
Query: 240 HMLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSN---PLLIGHGALSTLGLLLLDLAGAV 296
+L + + V + W L Y+ S N +I G L LL+ V
Sbjct: 261 WLLFV------SDTDVLADACWALSYL--SDGPNDKIQAVIDAGVCRRLVELLMHNDYKV 312
Query: 297 QKTEDAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSL 356
P LR + N++T G +Q + +AL LL + S+
Sbjct: 313 -----------VSPALRAVGNIVT-------GDDIQTQVILNCSALQSLLHLLSSPKESI 354
Query: 357 LPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLL 391
E W ++N+TA + + +++ ++ L+ +L
Sbjct: 355 KKEACWTISNITAGNRAQIQTVIDANIFPALISIL 389
Score = 37.0 bits (84), Expect = 0.041
Identities = 31/128 (24%), Positives = 53/128 (41%), Gaps = 8/128 (6%)
Query: 328 GGQMQLRDERVVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPL 387
G +Q R A+ I ++ + + + +W L N+ +S +L +++ PL
Sbjct: 157 GNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPL 216
Query: 388 LQLLPVSNVV-----SVMVLTVLCNVAEKGPAYCQRLWPGPLLPALLHTLAFSDTEVVGQ 442
LQL N + +V L+ LC P + + P L L L SDT+V+
Sbjct: 217 LQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAK---VSPCLNVLSWLLFVSDTDVLAD 273
Query: 443 SLELLHLL 450
+ L L
Sbjct: 274 ACWALSYL 281
>gi|34485722 karyopherin alpha 3 [Homo sapiens]
Length = 521
Score = 49.7 bits (117), Expect = 6e-06
Identities = 101/486 (20%), Positives = 190/486 (39%), Gaps = 61/486 (12%)
Query: 16 VEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQ 75
VE +RR R E LRK +R++ L+ KR + + E + ++ L+ A
Sbjct: 22 VETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNAT 81
Query: 76 RGTEEKEREGALVSLRRGLQHPETQQTFIRL--EGSMRTLVGLLT-SNQALLQLEAARCL 132
++ + + V R L + L G + LV L + LQ EAA L
Sbjct: 82 --SDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWAL 139
Query: 133 HEL-SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQG 191
+ S + T A A L L S + E ++ LGN+I + R ++ G
Sbjct: 140 TNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLG 199
Query: 192 IV-PALAACIQSPHVAVLEALGYALSQLLQAEEAP------EKIIPSILASTLPQHMLQM 244
+V P L+ S + L + + + L + ++ P ++I+P++ L H
Sbjct: 200 VVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPAL--CVLIYH---- 253
Query: 245 LQPGPKLNPGVAVEFAWCLHYIICSQVSNPLLIGHGALSTLGLLLLDLAGAVQKTEDAGL 304
+ + V+ W L Y+ + N +Q D+G+
Sbjct: 254 ------TDINILVDTVWALSYL--TDGGNE--------------------QIQMVIDSGV 285
Query: 305 ELLACPVLRCLSNLLTEAAVETVGGQMQLRDE--RVVAALFILLQF---FFQKQPSLLPE 359
P+L + AA+ VG + DE +VV +L F + + E
Sbjct: 286 VPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKE 345
Query: 360 GLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNV-VSVMVLTVLCNVAEKG-PAYCQ 417
+W L+N+TA + +++ LI ++ L + + N+ G +
Sbjct: 346 AVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVE 405
Query: 418 RLWPGPLLPALLHTLAFSDTEVVGQSLE-LLHLLFLYQPEA--VQVFLQQSG----LQAL 470
L ++P + L+ D++VV L+ L ++L + EA + +++ G ++ L
Sbjct: 406 YLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVL 465
Query: 471 ERHQEE 476
++H+ E
Sbjct: 466 QQHENE 471
>gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]
Length = 659
Score = 43.9 bits (102), Expect = 3e-04
Identities = 39/154 (25%), Positives = 68/154 (44%), Gaps = 3/154 (1%)
Query: 93 GLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLEAARCLHELSHS-EQSTVAEACLPAT 151
G + ++ I E M +V L+ + ++L A RCLH LS S +Q +
Sbjct: 355 GANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVW 414
Query: 152 SYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQSPHVAVLEAL 211
L+ L + + + + L NL++E + +L G V L QS + A+
Sbjct: 415 KPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNG 474
Query: 212 GYALSQLLQAEEAPEKIIPSILASTLPQHMLQML 245
+AL + A +A +KI IL S + + ++L
Sbjct: 475 IWALMNM--AFQAEQKIKADILRSLSTEQLFRLL 506
Score = 41.2 bits (95), Expect = 0.002
Identities = 37/150 (24%), Positives = 66/150 (44%), Gaps = 7/150 (4%)
Query: 148 LPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQSPHVAV 207
+P YLL +S S++ C LG+L + +E + LL I+PAL + SP +
Sbjct: 49 VPRLLYLLQQETS-STELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKF 107
Query: 208 LEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQMLQPGPKLNPGVAVEFAWCLHYII 267
+EA L + + PE+++ +T+ H++ +L + F+ C
Sbjct: 108 IEACLRCLRTIFTSPVTPEELL--YTDATVIPHLMALLSRSRYTQEYICQIFSHCCK--- 162
Query: 268 CSQVSNPLLIGHGALSTLGLLLLDLAGAVQ 297
+L HGA+ + LL L+ V+
Sbjct: 163 -GPDHQTILFNHGAVQNIAHLLTSLSYKVR 191
>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
[Homo sapiens]
Length = 558
Score = 41.6 bits (96), Expect = 0.002
Identities = 38/161 (23%), Positives = 71/161 (44%), Gaps = 4/161 (2%)
Query: 80 EKEREGALVSLRRGLQHPETQQTF-IRLEGSMRTLVGLLTSNQALLQLEAARCLHELSHS 138
E EG L L + L T+ + I+ G ++ LLT Q+ + + A + E++ +
Sbjct: 20 EDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTP-QSSCKAKVANIIAEVAKN 78
Query: 139 EQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAA 198
E + S L+ L+S + + LGN+ +S +++ QL+ G++P L
Sbjct: 79 EFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVK 138
Query: 199 C--IQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTL 237
I + A+ E A L + E + E+ + +A L
Sbjct: 139 LLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEEL 179
>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
[Homo sapiens]
Length = 559
Score = 41.6 bits (96), Expect = 0.002
Identities = 38/161 (23%), Positives = 71/161 (44%), Gaps = 4/161 (2%)
Query: 80 EKEREGALVSLRRGLQHPETQQTF-IRLEGSMRTLVGLLTSNQALLQLEAARCLHELSHS 138
E EG L L + L T+ + I+ G ++ LLT Q+ + + A + E++ +
Sbjct: 21 EDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTP-QSSCKAKVANIIAEVAKN 79
Query: 139 EQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAA 198
E + S L+ L+S + + LGN+ +S +++ QL+ G++P L
Sbjct: 80 EFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVK 139
Query: 199 C--IQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTL 237
I + A+ E A L + E + E+ + +A L
Sbjct: 140 LLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEEL 180
>gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens]
Length = 385
Score = 41.2 bits (95), Expect = 0.002
Identities = 37/150 (24%), Positives = 66/150 (44%), Gaps = 7/150 (4%)
Query: 148 LPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQSPHVAV 207
+P YLL +S S++ C LG+L + +E + LL I+PAL + SP +
Sbjct: 49 VPRLLYLLQQETS-STELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKF 107
Query: 208 LEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQMLQPGPKLNPGVAVEFAWCLHYII 267
+EA L + + PE+++ +T+ H++ +L + F+ C
Sbjct: 108 IEACLRCLRTIFTSPVTPEELL--YTDATVIPHLMALLSRSRYTQEYICQIFSHCCK--- 162
Query: 268 CSQVSNPLLIGHGALSTLGLLLLDLAGAVQ 297
+L HGA+ + LL L+ V+
Sbjct: 163 -GPDHQTILFNHGAVQNIAHLLTSLSYKVR 191
>gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens]
Length = 385
Score = 41.2 bits (95), Expect = 0.002
Identities = 37/150 (24%), Positives = 66/150 (44%), Gaps = 7/150 (4%)
Query: 148 LPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQSPHVAV 207
+P YLL +S S++ C LG+L + +E + LL I+PAL + SP +
Sbjct: 49 VPRLLYLLQQETS-STELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKF 107
Query: 208 LEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQMLQPGPKLNPGVAVEFAWCLHYII 267
+EA L + + PE+++ +T+ H++ +L + F+ C
Sbjct: 108 IEACLRCLRTIFTSPVTPEELL--YTDATVIPHLMALLSRSRYTQEYICQIFSHCCK--- 162
Query: 268 CSQVSNPLLIGHGALSTLGLLLLDLAGAVQ 297
+L HGA+ + LL L+ V+
Sbjct: 163 -GPDHQTILFNHGAVQNIAHLLTSLSYKVR 191
>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
[Homo sapiens]
Length = 607
Score = 39.3 bits (90), Expect = 0.008
Identities = 49/218 (22%), Positives = 87/218 (39%), Gaps = 34/218 (15%)
Query: 48 DAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPET-------- 99
D E++ EGC+ +L Q L Q T EK + ++ L L P++
Sbjct: 17 DKTEDSLEGCLDCLL------QALAQNNTETSEKIQASGILQLFASLLTPQSSCKAKVAN 70
Query: 100 ------QQTFIRLE----GSMRTLVGLLTSNQALLQLEAARCLHEL---SHSEQSTV--- 143
+ F+R+ G + LV LL S + L+ R L + SH +S V
Sbjct: 71 IIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQA 130
Query: 144 --AEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAAC-- 199
A+ + L + + + + L N E+++++ QL+ G++P L
Sbjct: 131 GGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLG 190
Query: 200 IQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTL 237
I + A+ E A L + E + E+ + +A L
Sbjct: 191 IHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEEL 228
>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
[Homo sapiens]
Length = 607
Score = 39.3 bits (90), Expect = 0.008
Identities = 49/218 (22%), Positives = 87/218 (39%), Gaps = 34/218 (15%)
Query: 48 DAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPET-------- 99
D E++ EGC+ +L Q L Q T EK + ++ L L P++
Sbjct: 18 DKTEDSLEGCLDCLL------QALAQNNTETSEKIQASGILQLFASLLTPQSSCKAKVAN 71
Query: 100 ------QQTFIRLE----GSMRTLVGLLTSNQALLQLEAARCLHEL---SHSEQSTV--- 143
+ F+R+ G + LV LL S + L+ R L + SH +S V
Sbjct: 72 IIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQA 131
Query: 144 --AEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAAC-- 199
A+ + L + + + + L N E+++++ QL+ G++P L
Sbjct: 132 GGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLG 191
Query: 200 IQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTL 237
I + A+ E A L + E + E+ + +A L
Sbjct: 192 IHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEEL 229
>gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1
[Homo sapiens]
Length = 608
Score = 39.3 bits (90), Expect = 0.008
Identities = 49/218 (22%), Positives = 87/218 (39%), Gaps = 34/218 (15%)
Query: 48 DAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPET-------- 99
D E++ EGC+ +L Q L Q T EK + ++ L L P++
Sbjct: 18 DKTEDSLEGCLDCLL------QALAQNNTETSEKIQASGILQLFASLLTPQSSCKAKVAN 71
Query: 100 ------QQTFIRLE----GSMRTLVGLLTSNQALLQLEAARCLHEL---SHSEQSTV--- 143
+ F+R+ G + LV LL S + L+ R L + SH +S V
Sbjct: 72 IIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQA 131
Query: 144 --AEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAAC-- 199
A+ + L + + + + L N E+++++ QL+ G++P L
Sbjct: 132 GGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLG 191
Query: 200 IQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTL 237
I + A+ E A L + E + E+ + +A L
Sbjct: 192 IHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEEL 229
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 38.1 bits (87), Expect = 0.018
Identities = 39/130 (30%), Positives = 65/130 (50%), Gaps = 25/130 (19%)
Query: 17 EELRRRRRER--EAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETE-VQQFLRQ 73
++L+++RRE+ + R+A +E++L+ + L+ + + L E E +Q+ RQ
Sbjct: 323 KDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERK---------LQELELLQEAQRQ 373
Query: 74 AQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQL---EAAR 130
A+R +E+E RR QH E QQ LEG +R S QA ++L EAAR
Sbjct: 374 AERLLQEEEE-------RRRSQHRELQQA---LEGQLREAEQARASMQAEMELKEEEAAR 423
Query: 131 CLHELSHSEQ 140
+ E+
Sbjct: 424 QRQRIKELEE 433
Score = 33.5 bits (75), Expect = 0.45
Identities = 28/98 (28%), Positives = 51/98 (52%), Gaps = 4/98 (4%)
Query: 8 RLRPTVCGVEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEV 67
R R + +EE+++R +E KARR+++ S R+ + EE E + + E
Sbjct: 423 RQRQRIKELEEMQQRLQEALQLEVKARRDEE--SVRIAQTRLLEEEEEKLKQLMQLKEEQ 480
Query: 68 QQFLRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIR 105
++++ +AQ+ EE ++E A S R LQ + Q +R
Sbjct: 481 ERYIERAQQEKEELQQEMAQQS--RSLQQAQQQLEEVR 516
>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
Length = 509
Score = 37.0 bits (84), Expect = 0.041
Identities = 31/116 (26%), Positives = 50/116 (43%), Gaps = 4/116 (3%)
Query: 137 HSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPAL 196
HS Q A A L+ L E + L + + + + ++ G VP L
Sbjct: 113 HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLL 172
Query: 197 AACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQM-LQPGPKL 251
CIQ P +A+ ALS + A+ +PE + +++ + H+ QM L P KL
Sbjct: 173 VLCIQEPEIALKRIAASALSDI--AKHSPE-LAQTVVDAGAVAHLAQMILNPDAKL 225
>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
Length = 458
Score = 37.0 bits (84), Expect = 0.041
Identities = 31/116 (26%), Positives = 50/116 (43%), Gaps = 4/116 (3%)
Query: 137 HSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPAL 196
HS Q A A L+ L E + L + + + + ++ G VP L
Sbjct: 113 HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLL 172
Query: 197 AACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQM-LQPGPKL 251
CIQ P +A+ ALS + A+ +PE + +++ + H+ QM L P KL
Sbjct: 173 VLCIQEPEIALKRIAASALSDI--AKHSPE-LAQTVVDAGAVAHLAQMILNPDAKL 225
>gi|194294548 hsp70-interacting protein [Homo sapiens]
Length = 359
Score = 36.6 bits (83), Expect = 0.054
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 25/178 (14%)
Query: 17 EELRRRRREREAALRKARREQQLVSK---RLLRNDAPEEAGEGCVAAILGETEVQQFLRQ 73
EE R+ +E +A + +RE+ K R+L P AGE
Sbjct: 69 EERRQWLQEAMSAAFRGQREEVEQMKSCLRVLSQPMPPTAGE------------------ 110
Query: 74 AQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVG-LLTSNQALLQLEAARCL 132
A++ +++EREGAL L ++ + F +L G M LVG L + A L+ AA+ +
Sbjct: 111 AEQAADQQEREGALELLADLCENMDNAADFCQLSG-MHLLVGRYLEAGAAGLRWRAAQLI 169
Query: 133 HELSHSEQSTVAEAC-LPATSYLLTYLSSHSSDFIEL-CLYTLGNLIVESEAVRRQLL 188
S + + + L A LL L + D + + L+ + L+ E EA Q L
Sbjct: 170 GTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLLQFL 227
>gi|112363070 hsp70-interacting protein [Homo sapiens]
Length = 359
Score = 36.6 bits (83), Expect = 0.054
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 25/178 (14%)
Query: 17 EELRRRRREREAALRKARREQQLVSK---RLLRNDAPEEAGEGCVAAILGETEVQQFLRQ 73
EE R+ +E +A + +RE+ K R+L P AGE
Sbjct: 69 EERRQWLQEAMSAAFRGQREEVEQMKSCLRVLSQPMPPTAGE------------------ 110
Query: 74 AQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVG-LLTSNQALLQLEAARCL 132
A++ +++EREGAL L ++ + F +L G M LVG L + A L+ AA+ +
Sbjct: 111 AEQAADQQEREGALELLADLCENMDNAADFCQLSG-MHLLVGRYLEAGAAGLRWRAAQLI 169
Query: 133 HELSHSEQSTVAEAC-LPATSYLLTYLSSHSSDFIEL-CLYTLGNLIVESEAVRRQLL 188
S + + + L A LL L + D + + L+ + L+ E EA Q L
Sbjct: 170 GTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLLQFL 227
>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
sapiens]
Length = 506
Score = 35.8 bits (81), Expect = 0.091
Identities = 46/185 (24%), Positives = 73/185 (39%), Gaps = 19/185 (10%)
Query: 298 KTEDAGLELLACPVLR----CLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQ 353
K + + +ELL CP LR CLS L + G M L+ V +++++ F
Sbjct: 321 KGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGV--SIYLIQVIFGAVD 378
Query: 354 PSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNVVSVMVLTVLCNVAEKGP 413
G ++N+L P+ +LL + L ++P + L VL
Sbjct: 379 LPAKLVGFLVINSL-GRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAAS 437
Query: 414 AYCQRLWPGPLLPALLHTLAFSDTEVVGQSLELLHLLFLYQPEAVQVFLQQSGLQALERH 473
C L+ G L P ++ + E +GQ L P+ VQ + G Q R
Sbjct: 438 FNCIFLYTGELYPTMIRAVTVLLPETLGQPL----------PDTVQDLESRKGKQT--RQ 485
Query: 474 QEEAQ 478
Q+E Q
Sbjct: 486 QQEHQ 490
>gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo
sapiens]
Length = 528
Score = 35.4 bits (80), Expect = 0.12
Identities = 37/138 (26%), Positives = 60/138 (43%), Gaps = 27/138 (19%)
Query: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEV--QQFLRQA 74
+E +RRRE E LR+ E++ + + LR E+ + +AA+ +T V QQ+ Q
Sbjct: 209 KEEEKRRREEEERLRREEEERRRIEEERLR---LEQQKQQIMAALNSQTAVQFQQYAAQQ 265
Query: 75 QRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLEAARCLHE 134
G E+++ L R LQ QQ Q L Q++ A+
Sbjct: 266 YPGNYEQQQ-----ILIRQLQEQHYQQYM-----------------QQLYQVQLAQQQAA 303
Query: 135 LSHSEQSTVAEACLPATS 152
L ++ VA + LP +S
Sbjct: 304 LQKQQEVVVAGSSLPTSS 321
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 35.0 bits (79), Expect = 0.16
Identities = 35/105 (33%), Positives = 48/105 (45%), Gaps = 14/105 (13%)
Query: 17 EELRRRRREREAALRKARREQQLVSKR-LLRNDAPEEAGEGCVAAILGETEVQQFLR--- 72
+ELRR R+E E ++ RREQQL K+ R + EE E E +Q LR
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ 343
Query: 73 ------QAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMR 111
Q +R EE+ RE L R Q E ++ +R E +R
Sbjct: 344 EERREQQLRREQEEERREQQL----RREQEEERREQQLRREQQLR 384
Score = 31.6 bits (70), Expect = 1.7
Identities = 35/118 (29%), Positives = 57/118 (48%), Gaps = 15/118 (12%)
Query: 4 RRQGRLRPTVCGVEELRRRRR-EREAALRKA---RREQQLVSKRLLRNDAPEE------A 53
RR+ +LR ++LRR ++ RE LR+ RREQQL ++ LR + EE
Sbjct: 384 RREQQLRRE----QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 54 GEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMR 111
E + E E ++ + + TE E+E L+R Q E ++ +++LE R
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD-QEEERRERWLKLEEEER 496
Score = 31.2 bits (69), Expect = 2.3
Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 9/97 (9%)
Query: 18 ELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQRG 77
ELRR+ RE + R+ R++ R+ + + +E + E ++Q+ Q QR
Sbjct: 217 ELRRKGREEKQQQRRERQD------RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE 270
Query: 78 TEEKE---REGALVSLRRGLQHPETQQTFIRLEGSMR 111
+E+E R+ LRR Q E QQ +R E +R
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307
Score = 30.4 bits (67), Expect = 3.8
Identities = 29/97 (29%), Positives = 44/97 (45%), Gaps = 3/97 (3%)
Query: 15 GVEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQA 74
G E +RRR+ERE R+ E Q ++LLR + + + + E+QQ Q
Sbjct: 975 GEEPEKRRRQEREKKYRE-EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL 1033
Query: 75 QRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMR 111
R EE+E+ R+ + E QQ +L G R
Sbjct: 1034 LR--EEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Score = 30.0 bits (66), Expect = 5.0
Identities = 18/51 (35%), Positives = 26/51 (50%)
Query: 4 RRQGRLRPTVCGVEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAG 54
+R+ R P E+ RR+RRERE L+ E+QL + + EE G
Sbjct: 805 QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG 855
Score = 29.3 bits (64), Expect = 8.6
Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 1/67 (1%)
Query: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQR 76
E +RRR+ERE RK ++ QQ ++LL + + + E E+QQ Q R
Sbjct: 947 EREKRRRQERERQYRKDKKLQQ-KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR 1005
Query: 77 GTEEKER 83
EK R
Sbjct: 1006 EEREKRR 1012
Score = 29.3 bits (64), Expect = 8.6
Identities = 25/85 (29%), Positives = 35/85 (41%), Gaps = 2/85 (2%)
Query: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQR 76
EE +RRR+ + E Q ++LLR + + + E EVQQ Q R
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 77 GTEEKEREGALVSLRRGLQHPETQQ 101
EK R L R+ + E QQ
Sbjct: 1156 EEPEKRRRQELE--RQYREEEELQQ 1178
Score = 29.3 bits (64), Expect = 8.6
Identities = 29/95 (30%), Positives = 46/95 (48%), Gaps = 16/95 (16%)
Query: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQR 76
+E R+ E E LR+ REQQ LR+D + E +L E E QQ LR+ +R
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQ------LRHDRDRKFRE--EEQLLQEGEEQQ-LRRQER 1689
Query: 77 GTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMR 111
+ +E E + L+ E ++ F++ E +R
Sbjct: 1690 DRKFREEE-------QQLRRQERERKFLQEEQQLR 1717
>gi|55742693 zyg-11 homolog B [Homo sapiens]
Length = 744
Score = 34.3 bits (77), Expect = 0.27
Identities = 34/143 (23%), Positives = 64/143 (44%), Gaps = 18/143 (12%)
Query: 300 EDAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQ-----P 354
ED ++ +A ++ L+ L+ +G ++ + + LLQ QK
Sbjct: 460 EDQNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRQ--------LLQIVKQKTNQNSVD 511
Query: 355 SLLPEGLWLLNNLTANSPSFCTSLLS---LDLIEPLLQLLPVSNVVSVMVLTVLCNVAEK 411
+ L L L NLT SP+ C + L+L +L+ P + + VL +L N+AE
Sbjct: 512 TTLKFTLSALWNLTDESPTTCRHFIENQGLELFMRVLESFPTESSIQQKVLGLLNNIAEV 571
Query: 412 GPAYCQRLWPGPL--LPALLHTL 432
+ + +W + + +LLH++
Sbjct: 572 QELHSELMWKDFIDHISSLLHSV 594
>gi|8922873 GTPase, IMAP family member 4 [Homo sapiens]
Length = 329
Score = 33.9 bits (76), Expect = 0.35
Identities = 24/95 (25%), Positives = 44/95 (46%), Gaps = 3/95 (3%)
Query: 1 MWSRRQGRLRPTVCGVEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAA 60
M+ R + ++ ++EL R ERE A + E+++ R L + +E + +
Sbjct: 225 MYQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKI---RKLEDKVEQEKRKKQMEK 281
Query: 61 ILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQ 95
L E E +RQ + TE + ++G L + LQ
Sbjct: 282 KLAEQEAHYAVRQQRARTEVESKDGILELIMTALQ 316
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 33.5 bits (75), Expect = 0.45
Identities = 45/145 (31%), Positives = 67/145 (46%), Gaps = 17/145 (11%)
Query: 17 EELRRRRREREAALRKAR----REQQLVSKRLLRNDAPEEAGEGCVAAIL--GETEVQQF 70
EE RR+RE+E ALR+ R R+QQ + R L EE +L E E ++
Sbjct: 785 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 844
Query: 71 LR---QAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLE 127
R +AQR EE + R L+H E ++ R E ++ L+ Q Q E
Sbjct: 845 AREEEEAQRRLEENRLRMEEEAAR--LRHEEEERK--RKELEVQRQKELMRQRQQ--QQE 898
Query: 128 AARCLHELSHSEQSTVAEACLPATS 152
A R L + +Q +A+ LP++S
Sbjct: 899 ALRRLQQ--QQQQQQLAQMKLPSSS 921
Score = 30.0 bits (66), Expect = 5.0
Identities = 33/118 (27%), Positives = 51/118 (43%), Gaps = 20/118 (16%)
Query: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQR 76
EE RR++E ALR+ +REQ++ +R + ++ E R +R
Sbjct: 775 EEEELARRKQEEALRR-QREQEIALRRQREEEERQQQEEA-------------LRRLEER 820
Query: 77 GTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLEAARCLHE 134
EE+ER LR+ Q E + E + R L N+ ++ EAAR HE
Sbjct: 821 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRR----LEENRLRMEEEAARLRHE 872
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 33.5 bits (75), Expect = 0.45
Identities = 45/145 (31%), Positives = 67/145 (46%), Gaps = 17/145 (11%)
Query: 17 EELRRRRREREAALRKAR----REQQLVSKRLLRNDAPEEAGEGCVAAIL--GETEVQQF 70
EE RR+RE+E ALR+ R R+QQ + R L EE +L E E ++
Sbjct: 812 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 871
Query: 71 LR---QAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLE 127
R +AQR EE + R L+H E ++ R E ++ L+ Q Q E
Sbjct: 872 AREEEEAQRRLEENRLRMEEEAAR--LRHEEEERK--RKELEVQRQKELMRQRQQ--QQE 925
Query: 128 AARCLHELSHSEQSTVAEACLPATS 152
A R L + +Q +A+ LP++S
Sbjct: 926 ALRRLQQ--QQQQQQLAQMKLPSSS 948
Score = 30.0 bits (66), Expect = 5.0
Identities = 33/118 (27%), Positives = 51/118 (43%), Gaps = 20/118 (16%)
Query: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQR 76
EE RR++E ALR+ +REQ++ +R + ++ E R +R
Sbjct: 802 EEEELARRKQEEALRR-QREQEIALRRQREEEERQQQEEA-------------LRRLEER 847
Query: 77 GTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLEAARCLHE 134
EE+ER LR+ Q E + E + R L N+ ++ EAAR HE
Sbjct: 848 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRR----LEENRLRMEEEAARLRHE 899
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 33.5 bits (75), Expect = 0.45
Identities = 45/145 (31%), Positives = 67/145 (46%), Gaps = 17/145 (11%)
Query: 17 EELRRRRREREAALRKAR----REQQLVSKRLLRNDAPEEAGEGCVAAIL--GETEVQQF 70
EE RR+RE+E ALR+ R R+QQ + R L EE +L E E ++
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 850
Query: 71 LR---QAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLE 127
R +AQR EE + R L+H E ++ R E ++ L+ Q Q E
Sbjct: 851 AREEEEAQRRLEENRLRMEEEAAR--LRHEEEERK--RKELEVQRQKELMRQRQQ--QQE 904
Query: 128 AARCLHELSHSEQSTVAEACLPATS 152
A R L + +Q +A+ LP++S
Sbjct: 905 ALRRLQQ--QQQQQQLAQMKLPSSS 927
Score = 30.0 bits (66), Expect = 5.0
Identities = 33/118 (27%), Positives = 51/118 (43%), Gaps = 20/118 (16%)
Query: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQR 76
EE RR++E ALR+ +REQ++ +R + ++ E R +R
Sbjct: 781 EEEELARRKQEEALRR-QREQEIALRRQREEEERQQQEEA-------------LRRLEER 826
Query: 77 GTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLEAARCLHE 134
EE+ER LR+ Q E + E + R L N+ ++ EAAR HE
Sbjct: 827 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRR----LEENRLRMEEEAARLRHE 878
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 33.5 bits (75), Expect = 0.45
Identities = 45/145 (31%), Positives = 67/145 (46%), Gaps = 17/145 (11%)
Query: 17 EELRRRRREREAALRKAR----REQQLVSKRLLRNDAPEEAGEGCVAAIL--GETEVQQF 70
EE RR+RE+E ALR+ R R+QQ + R L EE +L E E ++
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 850
Query: 71 LR---QAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLE 127
R +AQR EE + R L+H E ++ R E ++ L+ Q Q E
Sbjct: 851 AREEEEAQRRLEENRLRMEEEAAR--LRHEEEERK--RKELEVQRQKELMRQRQQ--QQE 904
Query: 128 AARCLHELSHSEQSTVAEACLPATS 152
A R L + +Q +A+ LP++S
Sbjct: 905 ALRRLQQ--QQQQQQLAQMKLPSSS 927
Score = 30.0 bits (66), Expect = 5.0
Identities = 33/118 (27%), Positives = 51/118 (43%), Gaps = 20/118 (16%)
Query: 17 EELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQR 76
EE RR++E ALR+ +REQ++ +R + ++ E R +R
Sbjct: 781 EEEELARRKQEEALRR-QREQEIALRRQREEEERQQQEEA-------------LRRLEER 826
Query: 77 GTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLEAARCLHE 134
EE+ER LR+ Q E + E + R L N+ ++ EAAR HE
Sbjct: 827 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRR----LEENRLRMEEEAARLRHE 878
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,171,792
Number of Sequences: 37866
Number of extensions: 807252
Number of successful extensions: 3276
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 3093
Number of HSP's gapped (non-prelim): 218
length of query: 493
length of database: 18,247,518
effective HSP length: 106
effective length of query: 387
effective length of database: 14,233,722
effective search space: 5508450414
effective search space used: 5508450414
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.