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Search of human proteins with 93352554
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|93352554 GPR158-like 1 [Homo sapiens]
(2367 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|93352554 GPR158-like 1 [Homo sapiens] 4816 0.0
gi|239751284 PREDICTED: hypothetical protein XP_002347797 [Homo ... 2874 0.0
gi|93204867 G protein-coupled receptor 158 [Homo sapiens] 713 0.0
gi|38176300 nestin [Homo sapiens] 64 2e-09
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 62 5e-09
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 62 7e-09
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 62 7e-09
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 62 7e-09
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 62 7e-09
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 62 9e-09
gi|40255245 G protein-coupled receptor 51 [Homo sapiens] 60 3e-08
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 60 3e-08
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr... 59 6e-08
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s... 54 2e-06
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur... 52 9e-06
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso... 52 9e-06
gi|112821681 G protein-regulated inducer of neurite outgrowth 1 ... 50 3e-05
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 49 4e-05
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 48 1e-04
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform... 48 1e-04
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 48 1e-04
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 48 1e-04
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre... 47 2e-04
gi|157364934 fibrosin [Homo sapiens] 47 2e-04
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 47 2e-04
gi|38201621 eukaryotic translation initiation factor 4 gamma, 1 ... 47 3e-04
gi|38201627 eukaryotic translation initiation factor 4 gamma, 1 ... 47 3e-04
gi|38201625 eukaryotic translation initiation factor 4 gamma, 1 ... 47 3e-04
gi|38201623 eukaryotic translation initiation factor 4 gamma, 1 ... 47 3e-04
gi|38201619 eukaryotic translation initiation factor 4 gamma, 1 ... 47 3e-04
>gi|93352554 GPR158-like 1 [Homo sapiens]
Length = 2367
Score = 4816 bits (12493), Expect = 0.0
Identities = 2367/2367 (100%), Positives = 2367/2367 (100%)
Query: 1 MGTRGAVMPPPMWGLLGCCFVCAWALGGPRPIRSLPPLSSQVKPGSVPMQVPLEGAEAAL 60
MGTRGAVMPPPMWGLLGCCFVCAWALGGPRPIRSLPPLSSQVKPGSVPMQVPLEGAEAAL
Sbjct: 1 MGTRGAVMPPPMWGLLGCCFVCAWALGGPRPIRSLPPLSSQVKPGSVPMQVPLEGAEAAL 60
Query: 61 AYLYSGDAQQLSQVNCSERYEARGAGAMPGLPPSLQGAAGTLAQAANFLNMLLQANDIRE 120
AYLYSGDAQQLSQVNCSERYEARGAGAMPGLPPSLQGAAGTLAQAANFLNMLLQANDIRE
Sbjct: 61 AYLYSGDAQQLSQVNCSERYEARGAGAMPGLPPSLQGAAGTLAQAANFLNMLLQANDIRE 120
Query: 121 SSVEEDVEWYQALVRSVAEGDPRVYRALLTFNPPPGASHLQLALQATRTGEETILQDLSG 180
SSVEEDVEWYQALVRSVAEGDPRVYRALLTFNPPPGASHLQLALQATRTGEETILQDLSG
Sbjct: 121 SSVEEDVEWYQALVRSVAEGDPRVYRALLTFNPPPGASHLQLALQATRTGEETILQDLSG 180
Query: 181 NWVQEENPPGDLDTPALKKRVLTNDLGSLGSPKWPQADGYVGDTQQVRLSPPFLECQEGR 240
NWVQEENPPGDLDTPALKKRVLTNDLGSLGSPKWPQADGYVGDTQQVRLSPPFLECQEGR
Sbjct: 181 NWVQEENPPGDLDTPALKKRVLTNDLGSLGSPKWPQADGYVGDTQQVRLSPPFLECQEGR 240
Query: 241 LRPGWLITLSATFYGLKPDLSPEVRGQVQMDVDLQSVDINQCASGPGWYSNTHLCDLNST 300
LRPGWLITLSATFYGLKPDLSPEVRGQVQMDVDLQSVDINQCASGPGWYSNTHLCDLNST
Sbjct: 241 LRPGWLITLSATFYGLKPDLSPEVRGQVQMDVDLQSVDINQCASGPGWYSNTHLCDLNST 300
Query: 301 QCVPLESQGFVLGRYLCRCRPGFYGASPSGGLEESDFQTTGQFGFPEGRSGRLLQCLPCP 360
QCVPLESQGFVLGRYLCRCRPGFYGASPSGGLEESDFQTTGQFGFPEGRSGRLLQCLPCP
Sbjct: 301 QCVPLESQGFVLGRYLCRCRPGFYGASPSGGLEESDFQTTGQFGFPEGRSGRLLQCLPCP 360
Query: 361 EGCTSCMDATPCLVEEAAVLRAAVLACQACCMLAIFLSMLVSYRCRRNKRIWASGVVLLE 420
EGCTSCMDATPCLVEEAAVLRAAVLACQACCMLAIFLSMLVSYRCRRNKRIWASGVVLLE
Sbjct: 361 EGCTSCMDATPCLVEEAAVLRAAVLACQACCMLAIFLSMLVSYRCRRNKRIWASGVVLLE 420
Query: 421 TVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKLYRVLQLFLSRTAQ 480
TVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKLYRVLQLFLSRTAQ
Sbjct: 421 TVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKLYRVLQLFLSRTAQ 480
Query: 481 RSALLSSGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLVIRGHTPSGRHFYLCHHD 540
RSALLSSGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLVIRGHTPSGRHFYLCHHD
Sbjct: 481 RSALLSSGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLVIRGHTPSGRHFYLCHHD 540
Query: 541 RWDYIMVVAELLLLCWGSFLCYATRAVLSAFHEPRYMGIALHNELLLSAAFHTARFVLVP 600
RWDYIMVVAELLLLCWGSFLCYATRAVLSAFHEPRYMGIALHNELLLSAAFHTARFVLVP
Sbjct: 541 RWDYIMVVAELLLLCWGSFLCYATRAVLSAFHEPRYMGIALHNELLLSAAFHTARFVLVP 600
Query: 601 SLHPDWTLLLFFFHTHSTVTTTLALIFIPKFWKLGAPPREEMVDEVCEDELDLQHSGSYL 660
SLHPDWTLLLFFFHTHSTVTTTLALIFIPKFWKLGAPPREEMVDEVCEDELDLQHSGSYL
Sbjct: 601 SLHPDWTLLLFFFHTHSTVTTTLALIFIPKFWKLGAPPREEMVDEVCEDELDLQHSGSYL 660
Query: 661 GSSIASAWSEHSLDPGDIRDELKKLYAQLEVHKTKEMAANNPHLPKKRGSSCQGLGRSFM 720
GSSIASAWSEHSLDPGDIRDELKKLYAQLEVHKTKEMAANNPHLPKKRGSSCQGLGRSFM
Sbjct: 661 GSSIASAWSEHSLDPGDIRDELKKLYAQLEVHKTKEMAANNPHLPKKRGSSCQGLGRSFM 720
Query: 721 RYLAEFPEALARQHSRDSGSPGHGSLPGSSRRRLLSSSLQEPEGTPALHKSRSTYDQRRE 780
RYLAEFPEALARQHSRDSGSPGHGSLPGSSRRRLLSSSLQEPEGTPALHKSRSTYDQRRE
Sbjct: 721 RYLAEFPEALARQHSRDSGSPGHGSLPGSSRRRLLSSSLQEPEGTPALHKSRSTYDQRRE 780
Query: 781 QDPPLLDSLLRRKLAKKASRTESRESVEGPPALGFRSASAHNLTVGERLPRARPASLQKS 840
QDPPLLDSLLRRKLAKKASRTESRESVEGPPALGFRSASAHNLTVGERLPRARPASLQKS
Sbjct: 781 QDPPLLDSLLRRKLAKKASRTESRESVEGPPALGFRSASAHNLTVGERLPRARPASLQKS 840
Query: 841 LSVASSREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLS 900
LSVASSREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLS
Sbjct: 841 LSVASSREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLS 900
Query: 901 APPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPTSTL 960
APPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPTSTL
Sbjct: 901 APPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPTSTL 960
Query: 961 APALLPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHH 1020
APALLPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHH
Sbjct: 961 APALLPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHH 1020
Query: 1021 SPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQ 1080
SPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQ
Sbjct: 1021 SPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQ 1080
Query: 1081 QGSMRSLGLAIKALTRSRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSK 1140
QGSMRSLGLAIKALTRSRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSK
Sbjct: 1081 QGSMRSLGLAIKALTRSRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSK 1140
Query: 1141 QAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGL 1200
QAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGL
Sbjct: 1141 QAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGL 1200
Query: 1201 AMLRQVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGN 1260
AMLRQVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGN
Sbjct: 1201 AMLRQVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGN 1260
Query: 1261 KAEICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAV 1320
KAEICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAV
Sbjct: 1261 KAEICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAV 1320
Query: 1321 CPWESADRGGLSPGSAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEP 1380
CPWESADRGGLSPGSAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEP
Sbjct: 1321 CPWESADRGGLSPGSAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEP 1380
Query: 1381 CPWEASEGGEDGKPAQEAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFRGPSA 1440
CPWEASEGGEDGKPAQEAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFRGPSA
Sbjct: 1381 CPWEASEGGEDGKPAQEAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFRGPSA 1440
Query: 1441 VSIQAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTGRE 1500
VSIQAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTGRE
Sbjct: 1441 VSIQAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTGRE 1500
Query: 1501 SLQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPCLDNSSSKAGSQ 1560
SLQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPCLDNSSSKAGSQ
Sbjct: 1501 SLQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPCLDNSSSKAGSQ 1560
Query: 1561 FLCNGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSAQVPRGGESQKDK 1620
FLCNGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSAQVPRGGESQKDK
Sbjct: 1561 FLCNGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSAQVPRGGESQKDK 1620
Query: 1621 EKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMSGS 1680
EKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMSGS
Sbjct: 1621 EKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMSGS 1680
Query: 1681 VGSKAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPNDTGKVSADLGP 1740
VGSKAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPNDTGKVSADLGP
Sbjct: 1681 VGSKAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPNDTGKVSADLGP 1740
Query: 1741 RERAVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCRPGE 1800
RERAVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCRPGE
Sbjct: 1741 RERAVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCRPGE 1800
Query: 1801 VCPWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGRLTSLGEDVS 1860
VCPWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGRLTSLGEDVS
Sbjct: 1801 VCPWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGRLTSLGEDVS 1860
Query: 1861 KGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVAEGHSLEATEKGDLRQDP 1920
KGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVAEGHSLEATEKGDLRQDP
Sbjct: 1861 KGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVAEGHSLEATEKGDLRQDP 1920
Query: 1921 KTGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQRPDQP 1980
KTGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQRPDQP
Sbjct: 1921 KTGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQRPDQP 1980
Query: 1981 KASSQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGD 2040
KASSQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGD
Sbjct: 1981 KASSQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGD 2040
Query: 2041 SQEEKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGS 2100
SQEEKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGS
Sbjct: 2041 SQEEKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGS 2100
Query: 2101 SEAAGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKA 2160
SEAAGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKA
Sbjct: 2101 SEAAGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKA 2160
Query: 2161 GPGGTEEHFSKAAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAE 2220
GPGGTEEHFSKAAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAE
Sbjct: 2161 GPGGTEEHFSKAAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAE 2220
Query: 2221 LCQWEITDPEGNKIKGTMADICPGEETGVPSEESGLLALTATRREFFPTAPEKPLCLLVH 2280
LCQWEITDPEGNKIKGTMADICPGEETGVPSEESGLLALTATRREFFPTAPEKPLCLLVH
Sbjct: 2221 LCQWEITDPEGNKIKGTMADICPGEETGVPSEESGLLALTATRREFFPTAPEKPLCLLVH 2280
Query: 2281 GPLDHFFPESKIPCPKVSRPASTFTLEGVRELQGPSGLEPRTSLAPEPSLQEAESQSSSL 2340
GPLDHFFPESKIPCPKVSRPASTFTLEGVRELQGPSGLEPRTSLAPEPSLQEAESQSSSL
Sbjct: 2281 GPLDHFFPESKIPCPKVSRPASTFTLEGVRELQGPSGLEPRTSLAPEPSLQEAESQSSSL 2340
Query: 2341 TEDSGQVAFEAQYEEFTPPTVYPWDWE 2367
TEDSGQVAFEAQYEEFTPPTVYPWDWE
Sbjct: 2341 TEDSGQVAFEAQYEEFTPPTVYPWDWE 2367
>gi|239751284 PREDICTED: hypothetical protein XP_002347797 [Homo
sapiens]
Length = 1674
Score = 2874 bits (7451), Expect = 0.0
Identities = 1404/1404 (100%), Positives = 1404/1404 (100%)
Query: 964 LLPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPA 1023
LLPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPA
Sbjct: 271 LLPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPA 330
Query: 1024 PARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGS 1083
PARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGS
Sbjct: 331 PARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGS 390
Query: 1084 MRSLGLAIKALTRSRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQAA 1143
MRSLGLAIKALTRSRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQAA
Sbjct: 391 MRSLGLAIKALTRSRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQAA 450
Query: 1144 LIPSDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAML 1203
LIPSDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAML
Sbjct: 451 LIPSDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAML 510
Query: 1204 RQVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKAE 1263
RQVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKAE
Sbjct: 511 RQVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKAE 570
Query: 1264 ICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAVCPW 1323
ICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAVCPW
Sbjct: 571 ICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAVCPW 630
Query: 1324 ESADRGGLSPGSAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEPCPW 1383
ESADRGGLSPGSAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEPCPW
Sbjct: 631 ESADRGGLSPGSAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEPCPW 690
Query: 1384 EASEGGEDGKPAQEAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFRGPSAVSI 1443
EASEGGEDGKPAQEAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFRGPSAVSI
Sbjct: 691 EASEGGEDGKPAQEAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFRGPSAVSI 750
Query: 1444 QAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTGRESLQ 1503
QAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTGRESLQ
Sbjct: 751 QAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTGRESLQ 810
Query: 1504 EKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPCLDNSSSKAGSQFLC 1563
EKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPCLDNSSSKAGSQFLC
Sbjct: 811 EKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPCLDNSSSKAGSQFLC 870
Query: 1564 NGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSAQVPRGGESQKDKEKM 1623
NGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSAQVPRGGESQKDKEKM
Sbjct: 871 NGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSAQVPRGGESQKDKEKM 930
Query: 1624 PGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMSGSVGS 1683
PGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMSGSVGS
Sbjct: 931 PGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMSGSVGS 990
Query: 1684 KAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPNDTGKVSADLGPRER 1743
KAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPNDTGKVSADLGPRER
Sbjct: 991 KAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPNDTGKVSADLGPRER 1050
Query: 1744 AVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCRPGEVCP 1803
AVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCRPGEVCP
Sbjct: 1051 AVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCRPGEVCP 1110
Query: 1804 WEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGRLTSLGEDVSKGM 1863
WEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGRLTSLGEDVSKGM
Sbjct: 1111 WEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGRLTSLGEDVSKGM 1170
Query: 1864 AKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVAEGHSLEATEKGDLRQDPKTG 1923
AKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVAEGHSLEATEKGDLRQDPKTG
Sbjct: 1171 AKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVAEGHSLEATEKGDLRQDPKTG 1230
Query: 1924 SFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQRPDQPKAS 1983
SFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQRPDQPKAS
Sbjct: 1231 SFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQRPDQPKAS 1290
Query: 1984 SQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGDSQE 2043
SQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGDSQE
Sbjct: 1291 SQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGDSQE 1350
Query: 2044 EKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGSSEA 2103
EKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGSSEA
Sbjct: 1351 EKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGSSEA 1410
Query: 2104 AGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKAGPG 2163
AGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKAGPG
Sbjct: 1411 AGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKAGPG 1470
Query: 2164 GTEEHFSKAAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAELCQ 2223
GTEEHFSKAAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAELCQ
Sbjct: 1471 GTEEHFSKAAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAELCQ 1530
Query: 2224 WEITDPEGNKIKGTMADICPGEETGVPSEESGLLALTATRREFFPTAPEKPLCLLVHGPL 2283
WEITDPEGNKIKGTMADICPGEETGVPSEESGLLALTATRREFFPTAPEKPLCLLVHGPL
Sbjct: 1531 WEITDPEGNKIKGTMADICPGEETGVPSEESGLLALTATRREFFPTAPEKPLCLLVHGPL 1590
Query: 2284 DHFFPESKIPCPKVSRPASTFTLEGVRELQGPSGLEPRTSLAPEPSLQEAESQSSSLTED 2343
DHFFPESKIPCPKVSRPASTFTLEGVRELQGPSGLEPRTSLAPEPSLQEAESQSSSLTED
Sbjct: 1591 DHFFPESKIPCPKVSRPASTFTLEGVRELQGPSGLEPRTSLAPEPSLQEAESQSSSLTED 1650
Query: 2344 SGQVAFEAQYEEFTPPTVYPWDWE 2367
SGQVAFEAQYEEFTPPTVYPWDWE
Sbjct: 1651 SGQVAFEAQYEEFTPPTVYPWDWE 1674
Score = 543 bits (1398), Expect = e-153
Identities = 264/264 (100%), Positives = 264/264 (100%)
Query: 1 MGTRGAVMPPPMWGLLGCCFVCAWALGGPRPIRSLPPLSSQVKPGSVPMQVPLEGAEAAL 60
MGTRGAVMPPPMWGLLGCCFVCAWALGGPRPIRSLPPLSSQVKPGSVPMQVPLEGAEAAL
Sbjct: 1 MGTRGAVMPPPMWGLLGCCFVCAWALGGPRPIRSLPPLSSQVKPGSVPMQVPLEGAEAAL 60
Query: 61 AYLYSGDAQQLSQVNCSERYEARGAGAMPGLPPSLQGAAGTLAQAANFLNMLLQANDIRE 120
AYLYSGDAQQLSQVNCSERYEARGAGAMPGLPPSLQGAAGTLAQAANFLNMLLQANDIRE
Sbjct: 61 AYLYSGDAQQLSQVNCSERYEARGAGAMPGLPPSLQGAAGTLAQAANFLNMLLQANDIRE 120
Query: 121 SSVEEDVEWYQALVRSVAEGDPRVYRALLTFNPPPGASHLQLALQATRTGEETILQDLSG 180
SSVEEDVEWYQALVRSVAEGDPRVYRALLTFNPPPGASHLQLALQATRTGEETILQDLSG
Sbjct: 121 SSVEEDVEWYQALVRSVAEGDPRVYRALLTFNPPPGASHLQLALQATRTGEETILQDLSG 180
Query: 181 NWVQEENPPGDLDTPALKKRVLTNDLGSLGSPKWPQADGYVGDTQQVRLSPPFLECQEGR 240
NWVQEENPPGDLDTPALKKRVLTNDLGSLGSPKWPQADGYVGDTQQVRLSPPFLECQEGR
Sbjct: 181 NWVQEENPPGDLDTPALKKRVLTNDLGSLGSPKWPQADGYVGDTQQVRLSPPFLECQEGR 240
Query: 241 LRPGWLITLSATFYGLKPDLSPEV 264
LRPGWLITLSATFYGLKPDLSPEV
Sbjct: 241 LRPGWLITLSATFYGLKPDLSPEV 264
>gi|93204867 G protein-coupled receptor 158 [Homo sapiens]
Length = 1215
Score = 713 bits (1840), Expect = 0.0
Identities = 437/1062 (41%), Positives = 588/1062 (55%), Gaps = 131/1062 (12%)
Query: 50 QVPLEGAEAALAYLYSGDAQQLSQVNCSERYEARGA-GAMPGLP---PSLQGAAGTLAQA 105
+VP++ A +YLY+GD+ QL + NCS RYE G G P L PSL A TL A
Sbjct: 77 EVPMDVA----SYLYTGDSHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHA 132
Query: 106 ANFLNMLLQANDIRESSVEEDVEWYQALVRSVAEGDPRVYRALLTFNPPP-GASHLQLAL 164
NFLN++LQ+N RE ++++D++WYQALV S+ EG+P + RA +TF+ A Q+ L
Sbjct: 133 TNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFSTDSLSAPAPQVFL 192
Query: 165 QATRTGEETILQDLSGNWVQEENPPGDLD---------TPALKKRVLTNDLGSLGSPKWP 215
QATR +LQDLS + N + + P L +R LG W
Sbjct: 193 QATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGH-SWR 251
Query: 216 QADGYVGDTQQVRLSPPFLECQEGRLRPGWLITLSATFYGLKPDLSPEVRGQVQMDVDLQ 275
+ DG GD + SPP+LEC+ G +PGWL+TLS+ YGL+P+L PE RG +++D++LQ
Sbjct: 252 RKDGLGGDKSHFKWSPPYLECENGSYKPGWLVTLSSAIYGLQPNLVPEFRGVMKVDINLQ 311
Query: 276 SVDINQCASGPGWYSNTHLCDLNSTQCVPLESQGFVLGRYLCRCRPGFYGASPSGGLEES 335
VDI+QC+S GW+S TH C LN+++C+P++ GFVLG Y C C+ GFY G L +
Sbjct: 312 KVDIDQCSSD-GWFSGTHKCHLNNSECMPIKGLGFVLGAYECICKAGFYHP---GVLPVN 367
Query: 336 DFQTTGQ----FGFPEGRSGRLLQCLPCPEGCTSCMDATPCLVEEAAVLRAAVLACQACC 391
+F+ G G + S CLPC EGC C D +PC V+E LR A+++ QA C
Sbjct: 368 NFRRRGPDQHISGSTKDVSEEAYVCLPCREGCPFCADDSPCFVQEDKYLRLAIISFQALC 427
Query: 392 MLAIFLSMLVSYRCRRNKRIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWV 451
ML F+SMLV Y R+ K I ASG++LLET+LFG LLLYFPV ILYF+PS FRCI LRW
Sbjct: 428 MLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWA 487
Query: 452 RLLGFAIVYGTIILKLYRVLQLFLSRTAQRSALLSSGRLLRRLGLLLLPVLGFLAVWTVG 511
RLLGFA VYGT+ LKL+RVL++FLSRTAQR ++ GR++R L ++LL V FL WT
Sbjct: 488 RLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVILLVVFWFLIGWTSS 547
Query: 512 ALERGIQHAPLVIRGHTPSGRHFYLCHHDRWDYIMVVAELLLLCWGSFLCYATRAVLSAF 571
+ + L+ +G T F +C DRWDY+ VAE L L WG +LCYA R V SAF
Sbjct: 548 VCQNLEKQISLIGQGKTSDHLIFNMCLIDRWDYMTAVAEFLFLLWGVYLCYAVRTVPSAF 607
Query: 572 HEPRYMGIALHNELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIFIPKF 631
HEPRYM +A+HNEL++SA FHT RFVL L DW L+L+F HTH TVT T+ L+ IPKF
Sbjct: 608 HEPRYMAVAVHNELIISAIFHTIRFVLASRLQSDWMLMLYFAHTHLTVTVTIGLLLIPKF 667
Query: 632 WKLGAPPREEMVDEVCEDELDLQHSGSYLGSSIASAWSEHSLDPGDIRDELKKLYAQLEV 691
PR+++ E EDELD+ SGSYL SSI SAWSEHSLDP DIRDELKKLYAQLE+
Sbjct: 668 SHSSNNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKKLYAQLEI 727
Query: 692 HKTKEMAANNPHLPKKRGSSCQGLGRSFMRYLAEFPEALARQHSR-DSGSPGHGSLPGSS 750
+K K+M NNPHL KKR S +GLGRS MR + E PE ++RQ S+ D HG+ G++
Sbjct: 728 YKRKKMITNNPHLQKKRCSK-KGLGRSIMRRITEIPETVSRQCSKEDKEGADHGTAKGTA 786
Query: 751 RRRLLSSSLQEPEGTP-------------ALHKSRSTYDQRREQ---------------- 781
L+ + E G +L KS STYD R+Q
Sbjct: 787 ---LIRKNPPESSGNTGKSKEETLKNRVFSLKKSHSTYDHVRDQTEESSSLPTESQEEET 843
Query: 782 -DPPLLDSLLRRKLAKKASRTESRESVEGPPALGFRSASAHNLTVGERLPRARPASLQKS 840
+ L+SL +KL +K ES E P L +SASAHNL+ ++ R + LQKS
Sbjct: 844 TENSTLESLSGKKLTQKLKEDSEAESTESVP-LVCKSASAHNLSSEKKTGHPRTSMLQKS 902
Query: 841 LSV-ASSREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPL 899
LSV AS++EK L +A + Q EER K
Sbjct: 903 LSVIASAKEKTLGLAGKT-------QTAGVEERTK------------------------- 930
Query: 900 SAPPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPTST 959
S P P K + +H++ + + P P + P G+ + + ++PT
Sbjct: 931 SQKPLP-KDKETNRNHSNS---DNTETKDPAPQNSNPAEEPRKPQKSGIMKQQRVNPT-- 984
Query: 960 LAPALLPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGH 1019
T L P + + +CPWE +L
Sbjct: 985 -----------TANSDLNPGTTQMKDNFDIGEVCPWEVYDLTP----------------- 1016
Query: 1020 HSPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDV 1061
P P+ +++ + +S+ + E +HH+ +A +V
Sbjct: 1017 -GPVPSESKVQKHVSIVASEMEKNPTFSLKEKSHHKPKAAEV 1057
Score = 51.2 bits (121), Expect = 1e-05
Identities = 106/476 (22%), Positives = 165/476 (34%), Gaps = 125/476 (26%)
Query: 1842 QREKALEKGRLTSLGEDVSKGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSE 1901
Q+++ +KG LG + + + ++ + C E+K+ + + S
Sbjct: 741 QKKRCSKKG----LGRSIMRRITEIPETVSRQCSKEDKEGADHGTAKGTALIRKNPPESS 796
Query: 1902 VAEGHSLEATEKGDLRQDPKTGSFPEHI---TQEKA--PAADTEEFTTED-------GEK 1949
G S E T K + K+ S +H+ T+E + P EE TTE+ G+K
Sbjct: 797 GNTGKSKEETLKNRVFSLKKSHSTYDHVRDQTEESSSLPTESQEEETTENSTLESLSGKK 856
Query: 1950 TSHELQSVCPWETT---------APADSVSHLDRQRPDQPKAS----SQRLVSTGGRAAD 1996
+ +L+ E+T A A ++S ++ P+ S S ++++
Sbjct: 857 LTQKLKEDSEAESTESVPLVCKSASAHNLS--SEKKTGHPRTSMLQKSLSVIASAKEKTL 914
Query: 1997 VCPWDVPDAGVYKSDSSAKAETCPWEVTERIPV-KGVSRQDGKGDSQEEKGRAPEKSEPK 2055
AGV + S K +P K +R D+ E K AP+ S P
Sbjct: 915 GLAGKTQTAGVEERTKSQKP----------LPKDKETNRNHSNSDNTETKDPAPQNSNPA 964
Query: 2056 GVPVQKKPEMADFRQQEAV-------------------------CPWESQDGKGLSPQPA 2090
P +KP+ + +Q+ V CPWE D L+P P
Sbjct: 965 EEP--RKPQKSGIMKQQRVNPTTANSDLNPGTTQMKDNFDIGEVCPWEVYD---LTPGPV 1019
Query: 2091 PDASDRSRGSSEAAGSVET--------------RVAEVCLWEVVEAPSAKKAEICPWEAG 2136
P S + S A +E + AEVC + KAE+C WE+
Sbjct: 1020 PSESKVQKHVSIVASEMEKNPTFSLKEKSHHKPKAAEVC--QQSNQKRIDKAEVCLWESQ 1077
Query: 2137 GGAAEEGE-----------QERESQGQGEMFLQKAGPGGTEEHFSKAAAKPREQEAVCPG 2185
G + E E + + + G+ G +EE KA A E E
Sbjct: 1078 GQSILEDEKLLISKTPVLPERAKEENGGQPRAANVCAGQSEELPPKAVASKTENEN---- 1133
Query: 2186 EGTGSGGLLPQSGALDPELKVSPKEAGSMGS------------RMAELCQWEITDP 2229
L Q G E K S E GS AE+C WE P
Sbjct: 1134 --------LNQIG--HQEKKTSSSEENVRGSYNSSNNFQQPLTSRAEVCPWEFETP 1179
Score = 50.4 bits (119), Expect = 2e-05
Identities = 104/527 (19%), Positives = 187/527 (35%), Gaps = 71/527 (13%)
Query: 1015 PERGHHSPAPARARLWRALSVAVEKSRAGE---NEMDAEDAHHQREANDVDEDRPKIFPK 1071
P+ H S P A ++ R+G + +++ + H + D+ ++ K++ +
Sbjct: 665 PKFSHSSNNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKKLYAQ 724
Query: 1072 SHSLKAPV--------------QQGSMRSLGLAIKALTRSRSTYREKESVEESPEGQNSG 1117
K ++G RS+ I + + S KE E + G G
Sbjct: 725 LEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGADHGTAKG 784
Query: 1118 TAGESMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQ---QNAHTSRMLQVCQREGSR 1174
TA P S G+ K + + + S + Q +S + Q E +
Sbjct: 785 TALIRKNPPESSGNTGKSKEETLKNRVFSLKKSHSTYDHVRDQTEESSSLPTESQEEETT 844
Query: 1175 EQED----RGRRMTQGLGERKAERAGKTGLAMLRQVSRDKNIKQSKETPVGWQELPKAGL 1230
E G+++TQ L E +E + ++ + + N+ K+T + + L
Sbjct: 845 ENSTLESLSGKKLTQKLKE-DSEAESTESVPLVCKSASAHNLSSEKKTGHPRTSMLQKSL 903
Query: 1231 QSLGSADHRVAEVCPW-------EVTESETRQPD----SGNKAEICPWETSEGAPESRAL 1279
+ SA + + E T+S+ P + N + ET + AP++
Sbjct: 904 SVIASAKEKTLGLAGKTQTAGVEERTKSQKPLPKDKETNRNHSNSDNTETKDPAPQNSNP 963
Query: 1280 RQDPGDSQK----KRGEARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPGS 1335
++P QK K+ + D+ P + + + VCPWE D L+PG
Sbjct: 964 AEEPRKPQKSGIMKQQRVNPTTANSDLNPGTTQMKDNF--DIGEVCPWEVYD---LTPGP 1018
Query: 1336 APQDPGRIRDKSEAGDSVEARKVEK-PGWEAAGPEAHTPD------------ITKAEPCP 1382
P + K + S+ A ++EK P + H P I KAE C
Sbjct: 1019 VPSE-----SKVQKHVSIVASEMEKNPTFSLKEKSHHKPKAAEVCQQSNQKRIDKAEVCL 1073
Query: 1383 WEASEGG--EDGKPAQEAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPW---ESTDFRG 1437
WE+ ED K LP+ ++ G E L P T+
Sbjct: 1074 WESQGQSILEDEKLLISKTPVLPERAKEENGGQPRAANVCAGQSEELPPKAVASKTENEN 1133
Query: 1438 PSAVSIQAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELD 1484
+ + Q +S ++ ++ P +AE+CPWE +
Sbjct: 1134 LNQIGHQEKKTSSSEENVRGSYNSSNNFQQ---PLTSRAEVCPWEFE 1177
Score = 46.2 bits (108), Expect = 4e-04
Identities = 101/486 (20%), Positives = 174/486 (35%), Gaps = 61/486 (12%)
Query: 1185 QGLGERKAERAGKTGLAMLRQVSRDKNIKQSKETPVGWQELPKAGLQSLGSAD------- 1237
+GLG R + + RQ S++ T G + K +S G+
Sbjct: 748 KGLGRSIMRRITEIPETVSRQCSKEDKEGADHGTAKGTALIRKNPPESSGNTGKSKEETL 807
Query: 1238 -HRVAEVCPWEVTESETRQPDSGNKAEICPWETSEG-APESRALRQDPGDSQKKRGEARG 1295
+RV + T R D ++ P E+ E E+ L G ++ +
Sbjct: 808 KNRVFSLKKSHSTYDHVR--DQTEESSSLPTESQEEETTENSTLESLSGKKLTQKLKEDS 865
Query: 1296 KSEPIDVVPMMRKKPE--RLVREQEAVCPWESADRGGLSP-GSAPQDPGRIRDKSEAGDS 1352
++E + VP++ K L E++ P S + LS SA + + K++
Sbjct: 866 EAESTESVPLVCKSASAHNLSSEKKTGHPRTSMLQKSLSVIASAKEKTLGLAGKTQTAGV 925
Query: 1353 VEARKVEKP---GWEAAGPEAHTPDITKAEPCPWEASEGGEDGKPAQEAVKDLPQEKQKT 1409
E K +KP E +++ + +P P ++ E KP + + ++Q+
Sbjct: 926 EERTKSQKPLPKDKETNRNHSNSDNTETKDPAPQNSNPAEEPRKPQKSGI----MKQQRV 981
Query: 1410 RKATFWKEQKPGG-------DLESLCPWESTDFRG---PSAVSIQAPGS---SECSGSLG 1456
T + PG D+ +CPWE D PS +Q S SE +
Sbjct: 982 NPTTANSDLNPGTTQMKDNFDIGEVCPWEVYDLTPGPVPSESKVQKHVSIVASEMEKNPT 1041
Query: 1457 SGI----------AEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTGRESLQEKE 1506
+ AEVC + + I KAE+C WE + ++ L + L E+
Sbjct: 1042 FSLKEKSHHKPKAAEVC--QQSNQKRIDKAEVCLWESQGQSILEDEKLLISKTPVLPERA 1099
Query: 1507 KASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPCLDNSSSKAGSQFLCNGG 1566
K G +A + Q E + P+ +S + + ++ G Q
Sbjct: 1100 KEENGGQ--------PRAANVCAGQSEELPPK-----AVASKTENENLNQIGHQEKKTSS 1146
Query: 1567 SRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTR-EEWTSAQVPRGGESQKDKEKMPG 1625
S V + Q+ ++ E+CPWE + S +P +K P
Sbjct: 1147 SE-ENVRGSYNSSNNFQQPLTSRAEVCPWEFETPAQPNAGRSVALPASSALSANKIAGPR 1205
Query: 1626 KSEIED 1631
K EI D
Sbjct: 1206 KEEIWD 1211
Score = 41.2 bits (95), Expect = 0.012
Identities = 69/320 (21%), Positives = 116/320 (36%), Gaps = 62/320 (19%)
Query: 1833 QKAGSESAEQREKALE-KGRLTSLG-EDVSKGMAKLCQQQETICIWENKDLRESPAQAPK 1890
QK+ S A +EK L G+ + G E+ +K L + +ET N D E+ AP+
Sbjct: 900 QKSLSVIASAKEKTLGLAGKTQTAGVEERTKSQKPLPKDKETNRNHSNSDNTETKDPAPQ 959
Query: 1891 ISDLPSSMSSEVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKT 1950
+S AE + R+ K+G + +D TT+ K
Sbjct: 960 --------NSNPAE----------EPRKPQKSGIMKQQRVNPTTANSDLNPGTTQ--MKD 999
Query: 1951 SHELQSVCPWE----TTAPADSVSHLDR-------QRPDQPKASSQRLVSTGGRAADVCP 1999
+ ++ VCPWE T P S S + + + P S + +AA+VC
Sbjct: 1000 NFDIGEVCPWEVYDLTPGPVPSESKVQKHVSIVASEMEKNPTFSLKEKSHHKPKAAEVCQ 1059
Query: 2000 WDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGDSQEEKGRAPEKSEPKGVPV 2059
KAE C WE + ++ K E+ + +P+ V
Sbjct: 1060 QS-------NQKRIDKAEVCLWESQGQSILEDEKLLISKTPVLPERAKEENGGQPRAANV 1112
Query: 2060 -----QKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGSSEAAGSVETRVAEV 2114
++ P A + E E+ + G + + + RGS ++ + +
Sbjct: 1113 CAGQSEELPPKAVASKTEN----ENLNQIGHQEKKTSSSEENVRGSYNSSNNFQQ----- 1163
Query: 2115 CLWEVVEAPSAKKAEICPWE 2134
P +AE+CPWE
Sbjct: 1164 --------PLTSRAEVCPWE 1175
Score = 39.7 bits (91), Expect = 0.036
Identities = 48/232 (20%), Positives = 82/232 (35%), Gaps = 45/232 (19%)
Query: 1803 PWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGRLTSLGEDV--S 1860
P Q + ++CPWEV + T G + + +EK SL E
Sbjct: 992 PGTTQMKDNFDIGEVCPWEVYDLTPGPVPSESKVQKHVSIVASEMEKNPTFSLKEKSHHK 1051
Query: 1861 KGMAKLCQQQET-------ICIWENKD--------------------LRESPAQAPKISD 1893
A++CQQ +C+WE++ +E P+ ++
Sbjct: 1052 PKAAEVCQQSNQKRIDKAEVCLWESQGQSILEDEKLLISKTPVLPERAKEENGGQPRAAN 1111
Query: 1894 LPSSMSSEVAEGHSLEATEKGDLRQ----DPKTGSFPEHITQEKAPAADTEEFTTEDGEK 1949
+ + S E+ TE +L Q + KT S E++ + + ++ T E
Sbjct: 1112 VCAGQSEELPPKAVASKTENENLNQIGHQEKKTSSSEENVRGSYNSSNNFQQPLTSRAE- 1170
Query: 1950 TSHELQSVCPWETTAPADSVSHLDRQRPDQPKASSQRLVSTGGRAADVCPWD 2001
VCPWE PA + P S+ ++ G R ++ WD
Sbjct: 1171 -------VCPWEFETPAQPNAGRSVALPASSALSANKI--AGPRKEEI--WD 1211
Score = 38.1 bits (87), Expect = 0.10
Identities = 92/433 (21%), Positives = 153/433 (35%), Gaps = 61/433 (14%)
Query: 1501 SLQEKEKASRKGSFGEMGEQTVK----AVQKLSQQQESVCPRESTVPGHSSPCLDNSSSK 1556
+L K G+ G+ E+T+K +++K + V R+ T S P
Sbjct: 786 ALIRKNPPESSGNTGKSKEETLKNRVFSLKKSHSTYDHV--RDQTEESSSLPTESQEEET 843
Query: 1557 AGSQFLCN-GGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSAQVPRGGE 1615
+ L + G + TQ +ED E+ E+ P +C E + PR
Sbjct: 844 TENSTLESLSGKKLTQKL-KEDSEAESTESVPL---VCKSASAHNLSSEKKTGH-PRTSM 898
Query: 1616 SQKD-------KEK---MPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRP 1665
QK KEK + GK++ V K + + K + S + + P P
Sbjct: 899 LQKSLSVIASAKEKTLGLAGKTQTAGVEERTKSQKPLPKDKETNRNHSNSDNTETKDPAP 958
Query: 1666 QDTERPQTLLQMSGSVGSKAADICPLDVEENLTAGKA---------EICPWEV-----GA 1711
Q++ + + S K + P +L G E+CPWEV G
Sbjct: 959 QNSNPAEEPRKPQKSGIMKQQRVNPTTANSDLNPGTTQMKDNFDIGEVCPWEVYDLTPGP 1018
Query: 1712 GAGEER-----ALGAEAIRKSPNDTGKVSADLGPRERAVTAPEKPQKPTPEWEVACPWGS 1766
E + ++ A + K+P + K + P+ A + QK + EV C W S
Sbjct: 1019 VPSESKVQKHVSIVASEMEKNPTFSLKEKSHHKPK-AAEVCQQSNQKRIDKAEV-CLWES 1076
Query: 1767 VGPGACSQHPGTLDADGPKAGFQELDHMGCRPGEVCPWEAQEAATSEKAKICPWEVSEGT 1826
G L + P + + G +P A + ++ P V+ T
Sbjct: 1077 QGQSILEDEK-LLISKTPVLPERAKEENGGQP------RAANVCAGQSEELPPKAVASKT 1129
Query: 1827 TGKGLDQKAGSESAEQREKALEKGRLTSLGEDVSKGMAKLCQQQETICIWENKDLRESPA 1886
+ L+Q E + +G S S + + +C WE E+PA
Sbjct: 1130 ENENLNQIGHQEKKTSSSEENVRGSYNS-----SNNFQQPLTSRAEVCPWE----FETPA 1180
Query: 1887 Q--APKISDLPSS 1897
Q A + LP+S
Sbjct: 1181 QPNAGRSVALPAS 1193
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 63.9 bits (154), Expect = 2e-09
Identities = 268/1213 (22%), Positives = 461/1213 (38%), Gaps = 169/1213 (13%)
Query: 704 LPKKRGSSCQGLGRSFMRYLAEFPEALARQHSRDSGSPGHGSLPGSSRRRLLSSSLQEPE 763
L ++ G + +G R + +A +L + R + + G+ RL LQ
Sbjct: 178 LARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRA-----VQGAREGRLELQQLQAER 232
Query: 764 GTPALHKSRSTYDQRRE-QDPPLLDSLLRRKLAKKASRTESRESVEGPPALGFRSASAHN 822
G L + R+ +QR E + L + + +LA +A E + G +S A
Sbjct: 233 G--GLLERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQ---------GLQSQIAQV 281
Query: 823 LTVGERLPRARPASLQKSLSVASSREKALLMASQAYLEETYRQAKEREERKKAKAAMASL 882
L ++L A L+ SLS+ + + LL A + L+ +K + K +
Sbjct: 282 LEGRQQL-----AHLKMSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLEL-QF 335
Query: 883 VRRPSARRLER--PRGAPLSAP-PSPAKSSSVDSSHTSGRLHEEARR----RLPHPPIRH 935
R P RRL P +P S P P PA + + + +AR P PP
Sbjct: 336 PRTPEGRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQ 395
Query: 936 QVSTPILALSGGLGEPRMLSPTS---TLAPALLPALAPTPAPA-LAPVPVSP--QSPNLL 989
S + A P L T AP L A A PA + P P P Q
Sbjct: 396 APSPAVDAEIRAQDAPLSLLQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEAS 455
Query: 990 TYICPWENAEL--PAKQENVPQEGPSGPERGHHSPAPARARLWRALSVAVEKSRAGENEM 1047
T P ++A L P ++ E G G + R + VEK A E ++
Sbjct: 456 TGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKV 515
Query: 1048 DAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGSMRSLGLAI----KALTRSRSTYRE 1103
+ E D++ + + P+++ +++SLG I K L E
Sbjct: 516 VSSLQQEIWEEEDLNRK------EIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLE 569
Query: 1104 KESVE------------ESPEGQNSGTAGE-SMGAPSRSPRLGRPKAVSKQAALIPSDDK 1150
+E+ E +S E +N + + P +G+ K K+ D
Sbjct: 570 RENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKE-------DT 622
Query: 1151 ESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAMLRQVSRDK 1210
++LQ+ Q + M + EG+ E + G ++ + + L L + ++
Sbjct: 623 QTLQSLQKENQELMKSL---EGNLETF-----LFPGTENQELVSSLQENLESLTALEKE- 673
Query: 1211 NIKQSKETPVGWQE----LPKAGLQSLGSADHRVAEVCPWEVTESETRQP----DSGNKA 1262
N + + VG +E L K + L S + E + E E ++P + +++
Sbjct: 674 NQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEA--FRSLEKENQEPLKTLEEEDQS 731
Query: 1263 EICPWETSEGAPESRALRQDPGDSQK-------KRGEARGKSEPIDVVPMMRKKPERLVR 1315
+ P ET E R+L + ++ + +R + G+ + + + P + E L
Sbjct: 732 IVRPLET-ENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKS 790
Query: 1316 -EQEAVCPWESADRGGLSPGSAPQDPGRIRDKS-EAGDSVEARKVEKPGWEAAGPE---- 1369
+QE P E+ ++ L ++++S EA S+E +E ++AG E
Sbjct: 791 LDQEIARPLENENQEFLKS---------LKEESVEAVKSLETEILES--LKSAGQENLET 839
Query: 1370 AHTPDITKAEPCPWEASEGGEDGKPAQEAVKDLPQEKQKTRKATF-WKEQKPGGDLESLC 1428
+P+ P E ++G + P ++ +++ P E + + TF E++ L SL
Sbjct: 840 LKSPETQAPLWTPEEINQGAMN--PLEKEIQE-PLESVEVNQETFRLLEEENQESLRSLG 896
Query: 1429 PWESTDFRGPSAVSIQAPGSSECSGSLGSGIAEVCL--WEAGDAPAIQKAEICPWE---L 1483
W + R P V ++ + E +LG G + L E Q A++ WE
Sbjct: 897 AWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVE 956
Query: 1484 DDNVMGQEMLSLGTGRESLQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCP----RE 1539
D + QE G E+ E E R+ G G++ V +L+ +E P E
Sbjct: 957 KDQELAQESPPGMAGVENEDEAELNLREQD-GFTGKEEVVEQGELNATEEVWIPGEGHPE 1015
Query: 1540 STVPGHSSPCLDNSSSKAGSQFLCNGGSRATQV------CPQEDLRPEAQEATPAKTEIC 1593
S P ++ +S K G++ L + ++ QV PQ PEA E + ++
Sbjct: 1016 SPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQG--LPEAIEPL-VEDDVA 1072
Query: 1594 PWEVNERTREEWTSAQVPRGGESQKDKEKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWES 1653
P ++ E P GES E PG + V P G + ++E + P
Sbjct: 1073 PG--GDQASPEVMLGSEPAMGESAAGAEPGPG----QGVGGLGDP-GHLTREEVMEP--P 1123
Query: 1654 VDPGSFSPQPRPQDTERPQTLLQMSGSVGSKAADI--CPLDVEENLTAGKAEICPWEVGA 1711
++ S + R Q E P+ L+ +G +G++ +++ D E G+ E E A
Sbjct: 1124 LEEESLEAK-RVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREES---EAEA 1179
Query: 1712 GAGEERALGAEAIRKSPNDTGKVSADLGPRERAVTAPEKPQKPTPEWEVACPWGSVGPGA 1771
G E A AE + + +D LG E P P+P + P PG
Sbjct: 1180 PRGAEEAFPAETLGHTGSDAPS-PWPLGSEEAEEDVPPVLVSPSPTY---TPILEDAPGP 1235
Query: 1772 CSQHPGTLDADGPKAGFQELDHMGCRPGEVCPWEAQEAATSEKAKICPWEVSEGTTGKGL 1831
Q G+ +A G EA SE+ ++ E+ EG +G
Sbjct: 1236 QPQAEGSQEASWGVQGRA---------------EALGKVESEQEELGSGEIPEGPQEEGE 1280
Query: 1832 DQKAGSESAEQRE 1844
+ + SE E E
Sbjct: 1281 ESREESEEDELGE 1293
Score = 38.5 bits (88), Expect = 0.079
Identities = 104/459 (22%), Positives = 172/459 (37%), Gaps = 71/459 (15%)
Query: 1692 DVEENLTAGKAEICP--WEVGAGAGEERALGAEAIRKSPNDTGKVSADLGPRERAVTAPE 1749
+V N A +AE C W A ER L A + G ++A R P
Sbjct: 108 EVARNRRAVEAEKCARAWLSSQVAELERELEALRVAHEEERVG-LNAQAACAPRCPAPPR 166
Query: 1750 KPQKPTPEWE-VACPWGSVGPGACSQHPGTLDADGPKAGFQE-LDHMGCRPGEVCPWEAQ 1807
P P PE E +A G GA G+QE + HM G+ +
Sbjct: 167 GPPAPAPEVEELARRLGEAWRGAVR-------------GYQERVAHMETSLGQARERLGR 213
Query: 1808 EAATSEKAKICPWEVSEGTTGKGLDQKAGSESA-----EQREKALEKGRLTSLG-EDVSK 1861
+ + ++ + + G L+++A E ++R +A EK +L E +
Sbjct: 214 AVQGAREGRL-ELQQLQAERGGLLERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQ 272
Query: 1862 GMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVAEGHSLEATEKGDLRQDPK 1921
G+ Q + + E + +++ L S+S EVA +L E L Q P
Sbjct: 273 GL-----QSQIAQVLEGRQ---------QLAHLKMSLSLEVATYRTLLEAENSRL-QTPG 317
Query: 1922 TGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQRPDQPK 1981
GS Q+ P + + T +G + L + P T+ P+ + L+ P K
Sbjct: 318 GGSKTSLSFQD--PKLELQFPRTPEGRRLGSLLPVLSP--TSLPSPLPATLETPVPAFLK 373
Query: 1982 ASSQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGDS 2041
T A+ P P A D+ +A+ P + + Q G+ +
Sbjct: 374 NQEFLQARTPTLASTPIP-PTPQAPSPAVDAEIRAQDAPLSLLQT--------QGGRKQA 424
Query: 2042 QEEKGRAPEKSEPK-GVP--VQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSR 2098
E P ++E + +P V PE ++QEA +D L+P +PD S
Sbjct: 425 PE-----PLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEA 479
Query: 2099 GSSEAAGSVETRVAEVC-------LWEVVEAPSAKKAEI 2130
E+ GS RV +C +W +VE +A + ++
Sbjct: 480 KDGESGGS---RVFSICRGEGEGQIWGLVEKETAIEGKV 515
Score = 32.0 bits (71), Expect = 7.4
Identities = 41/172 (23%), Positives = 69/172 (40%), Gaps = 13/172 (7%)
Query: 1338 QDPGRIRDKSEAGDSVEARKVEKPG--WEAAGPEAHTPDITKAEPCPWEASEGGEDGKPA 1395
++ GR D SE + + PG E A P P + +P W+ +G DG
Sbjct: 1357 EECGRDSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLL-LDPAAWDR-DGESDGFAD 1414
Query: 1396 QEAVKDLPQEKQKTRK---ATFWKEQKPGGDLESLCPWESTDFRGPSAVSIQAPGSSECS 1452
+E + +E Q+ + A W G L++L + +F +VS+ P
Sbjct: 1415 EEESGEEGEEDQEEGREPGAGRWGPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLR 1474
Query: 1453 GSLGSGIAEVCLWEAGDA--PAIQKAEICP--WELDDNVMGQEMLSLGTGRE 1500
G++ E+ D+ P+ + E P E +D V G L + +G E
Sbjct: 1475 GAVAGAPKTALETESQDSAEPSGSEEESDPVSLEREDKVPGP--LEIPSGME 1524
Score = 31.6 bits (70), Expect = 9.7
Identities = 48/217 (22%), Positives = 75/217 (34%), Gaps = 25/217 (11%)
Query: 1739 GPRERAVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCR- 1797
GP E E +PE S+ P H DG G + CR
Sbjct: 443 GPEEPGGQRQEASTGQSPE-----DHASLAPPLSPDHSSLEAKDGESGGSRVFSI--CRG 495
Query: 1798 PGEVCPWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGRLTSLGE 1857
GE W E T+ + K+ E + L++K +S + LEK L SLGE
Sbjct: 496 EGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDS----QVPLEKETLKSLGE 551
Query: 1858 DVSKGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVAEGHSLEATEKGDLR 1917
++ + + L Q EN+ + P S+ ++ SLE K L+
Sbjct: 552 EIQESLKTLENQSHETLERENQ-------------ECPRSLEEDLETLKSLEKENKELLK 598
Query: 1918 QDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTSHEL 1954
+ + P + T + +K + EL
Sbjct: 599 DVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQEL 635
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 62.4 bits (150), Expect = 5e-09
Identities = 301/1477 (20%), Positives = 504/1477 (34%), Gaps = 277/1477 (18%)
Query: 846 SREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAP-PS 904
+ E A L A + + + ++ EE ++A+A A + RL + L A PS
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAK-----ATPRLASTNSSVLGADLPS 119
Query: 905 PAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPTSTLAPAL 964
K + + +G+ +PHP V+ LSG SP + P+
Sbjct: 120 SMKEKAKAETEKAGKTGNS----MPHPATGKTVAN---LLSGK-------SPRKSAEPSA 165
Query: 965 LPAL-APTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPA 1023
L + T P + P +++ + + E+ G S
Sbjct: 166 NTTLVSETEEEGSVPAFGAAAKPGMVSA------GQADSSSEDTSSSSDETDVEGKPSVK 219
Query: 1024 PARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGS 1083
PA+ + A SV+ ++S A R+A + P+ V+ G+
Sbjct: 220 PAQVK---ASSVSTKESPA-------------RKAAPAPGKVGDVTPQ-------VKGGA 256
Query: 1084 MRSLGLAIKALTRSRSTYREKESVEESPEGQNS-------------------GTAGE--- 1121
+ A K S S+ ES EE+P G S GT G+
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGAT 316
Query: 1122 -----SMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQ 1176
GA + + G+P+ S+ S +ES +++ ++ L + G Q
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSE------SSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 1177 EDRGRRMTQGLGERKAERA--GKTGLAMLRQVS--RDKNIKQSKETPVGWQELPKAGLQS 1232
+ + A A GKTG A+ + + R+++ + S E +E P S
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 1233 LGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAPESRALRQDPGDSQKKRGE 1292
+ R A + ++ A P +T A + + +Q+ DS+ E
Sbjct: 431 GKAPQVRAA--------SAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE-DSRSSSEE 481
Query: 1293 ARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPGSAPQDPGRIRDKSEAGDS 1352
+ E + + + KP + + V P + G L G+ P PG++ A S
Sbjct: 482 SDSDREALAAMNAAQVKP---LGKSPQVKPASTMGMGPLGKGAGPVPPGKV---GPATPS 535
Query: 1353 VEARKVEKPGWEAAGPEAHTPD---ITKAEPCPWEASEGGEDGKPAQEAVKDLPQEKQKT 1409
+ K E+ ++ + + D T P ++ KP K PQ+
Sbjct: 536 AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595
Query: 1410 RKATFWKEQKPGGDLESLCPWESTDFRGPSAVSIQAPGSSECSGSLGSGIAEVCLWEAGD 1469
A K +KP + ES ES+D SA S +AP + + +A
Sbjct: 596 --AVQVKAEKPMDNSES--SEESSD----SADSEEAPAAMTAA-------------QAKP 634
Query: 1470 APAIQKAEICPWELDDNVMGQEMLSLGTGRESLQEKEKA-SRKGSFGEMGEQTVKAVQKL 1528
A I + + CP + + ++ + G ++ ++ A S GS + T + +
Sbjct: 635 ALKIPQTKACP-KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS 693
Query: 1529 SQQQESVCPRESTVPGHSSPCLDNSSSKAGSQFLCNGGSRATQVCPQEDLRPEAQEATPA 1588
S +ES E T G + S G Q +A V + L P
Sbjct: 694 SSSEESDSEEEKT--GLAVTVGQAKSVGKGLQV------KAASVPVKGSLGQGTAPVLPG 745
Query: 1589 KTEICPWEVNERTREEWTSAQVPRGGESQKDKEKMPG-----KSEIEDVTAWEKP---EG 1640
KT +V +E+ S+ E + D E+ K+ ++ A P
Sbjct: 746 KTGPTVTQVKAEKQEDSESS------EEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799
Query: 1641 QIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMSGSVGSKAADICPLDVEENLTAG 1700
K P + V + + Q P + P Q S + A + P + TA
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV-PSVGKAVATAA 858
Query: 1701 KAEICPWEVGAGAGEERALGAE-----AIRKSPNDTGKVSADLGPRERAVTAPEKPQKPT 1755
+A+ P E +G+ EE + E A K T ++ A L P A +P K PT
Sbjct: 859 QAQTGP-EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP---AKESPRKGAAPT 914
Query: 1756 PEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCRPGEV-------------- 1801
P G GP A G D G + +E D G P V
Sbjct: 915 PP-------GKTGPSAA--QAGKQDDSGSSS--EESDSDGEAPAAVTSAQVIKPPLIFVD 963
Query: 1802 ----------CPWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGR 1851
P +AQ A+T KA+ + +T + ++ E + L G
Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKAR------ASESTARSSSSESEDEDVIPATQCLTPGI 1017
Query: 1852 LTSLGE--------DVSKGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVA 1903
T++ MA +E+ I + K +E P A ++ ++ +
Sbjct: 1018 RTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKK-QEGP--ATQVDSAVGTLPATSP 1074
Query: 1904 EGHSLEATEKGDLRQDPKTGSFPEHITQEKAP--------AADTEEFTTEDGE-----KT 1950
+ S++A LR+ PK PE KAP ++D+ + EDGE K+
Sbjct: 1075 QSTSVQAKGTNKLRK-PK---LPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKS 1130
Query: 1951 SHELQSVCPWETTAPADSVSHLDRQRPDQPKASSQRLVS---------TGGRAADVCPW- 2000
+H L P T + + D A SQ L+S +A+ P
Sbjct: 1131 AHTLVGPTPSRTETLVEETA--AESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKL 1188
Query: 2001 ----DVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGDSQEEKGRAPEKSEPKG 2056
V K D K E P + + K ++ G + +K R P+K
Sbjct: 1189 DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG-TTPQKSRKPKKG---- 1243
Query: 2057 VPVQKKPEMADFRQQEAVC------PWESQDGK----------GLSPQPAPDASDRSRGS 2100
P+ + Q + PW + + L Q D ++ S
Sbjct: 1244 ---AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKES 1300
Query: 2101 SEAAGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKA 2160
S R S KK ++ E GG A ++ + +G+ KA
Sbjct: 1301 SRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGE--GGEASVSPEKTSTTSKGKAKRDKA 1358
Query: 2161 GPGGTEEHFSKAA-----AKPREQEAVCPGEGTGSGG 2192
G +E K + AK +E + G GT GG
Sbjct: 1359 S-GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGG 1394
Score = 62.0 bits (149), Expect = 7e-09
Identities = 95/414 (22%), Positives = 153/414 (36%), Gaps = 33/414 (7%)
Query: 1892 SDLPSSMSSEVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTS 1951
+DLPSSM E A+ + +A + G+ P TG ++ K+P E +
Sbjct: 115 ADLPSSMK-EKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
Query: 1952 HELQSVCPWETTAPADSVSHLDRQRPDQPKASSQRLVSTGGRAADVCPWDVPDAGVYKSD 2011
E SV + A VS + +SS G+ + V P V + V +
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS-VKPAQVKASSVSTKE 232
Query: 2012 SSA-KAETCPW---EVTERI------PVKGVSRQDGKGDSQEEKGRAPEKSEPKGVPVQK 2061
S A KA P +VT ++ P K + + + +S EE G E+ P G Q
Sbjct: 233 SPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEE-GSESEEEAPAGTRSQV 291
Query: 2062 KPEMADFRQQEAVCPWESQDGKGLSPQP----APDASDRSRGSSEAAGSVETRVAEVCLW 2117
K + + A P + GKG +P P AS G E + +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 351
Query: 2118 EVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKAGP------GGTEEHFSK 2171
E A + +A+ + GAA +E +G K GP G E S+
Sbjct: 352 ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ 411
Query: 2172 AAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAELCQWEITDPEG 2231
++++ + E P + S G PQ A K SP++ + T P
Sbjct: 412 SSSEESDSEEEAPAQAKPS-GKAPQVRAASAPAKESPRKGAAPAPPRK-------TGPAA 463
Query: 2232 NKIK-GTMADICPGEETGVPSEESGLLALTATRREFFPTAPE-KPLCLLVHGPL 2283
+++ G + S+ L A+ A + + +P+ KP + GPL
Sbjct: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPL 517
Score = 50.1 bits (118), Expect = 3e-05
Identities = 203/1042 (19%), Positives = 346/1042 (33%), Gaps = 136/1042 (13%)
Query: 739 GSPGHGSLPGSSRRRLLSSSLQEPEGTPALHKSRSTYDQRREQDPPLLDSLLRRKLAKKA 798
G+PG G+ P + +S + +S S E++ P +LL+ K + K
Sbjct: 309 GTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKT 368
Query: 799 SRTESRESVEGPPALGFRSASAHNLTVGERLPRARPASLQKSLSVASSREKALLMASQAY 858
S+ + + PA A G+ P A A RE+ SQ+
Sbjct: 369 SQVGAASA----PAKESPRKGAAPAPPGKTGPAVAKAQ-------AGKREED----SQSS 413
Query: 859 LEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSPAKSSSVDSSHTSG 918
EE+ ++E + + A VR SA E PR AP P K+ + G
Sbjct: 414 SEES--DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA--APAPPRKTGPAAAQVQVG 469
Query: 919 RLHEEARRRLPHPPI-RHQVSTPILALSGGLGEPRMLSPTSTLAPALL-PALAPTPAPAL 976
+ E++R R ++ A LG+ + P ST+ L P P
Sbjct: 470 KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP---- 525
Query: 977 APVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPAPARARLWRALSVA 1036
P V P +P+ + WE + +E+ P A++ A
Sbjct: 526 -PGKVGPATPS--AQVGKWEEDSESSSEESSDSSDGEVP---------------TAVAPA 567
Query: 1037 VEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGSMRSLGLAIKALTR 1096
EKS N + A+ P S K P Q+ + +
Sbjct: 568 QEKSLG--NILQAK-------------------PTSSPAKGPPQKAG------PVAVQVK 600
Query: 1097 SRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQ 1156
+ ES EES + +S A +M A P L P Q P
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIP-----QTKACP---------- 645
Query: 1157 QNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAMLRQVSRDKNIKQSK 1216
+ +T+ +V + + T G A G ++ + D + +
Sbjct: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG------TQRPAEDSSSSEES 699
Query: 1217 ETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAPES 1276
++ E K GL V + + + A + P +T +
Sbjct: 700 DS-----EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754
Query: 1277 RALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPGSA 1336
+A +Q+ +S ++ ++ + V KK + A P SA +PG
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP--SAKGTISAPGKV 812
Query: 1337 PQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEPCPWEASEGGEDGKPAQ 1396
+ + +S + R + A GP A P + KA +A G E+ +
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP-ASVPSVGKAVATAAQAQTGPEEDSGSS 871
Query: 1397 EAVKDLPQEKQKTRKATFWKEQKPGGDLE----SLCPWESTDFRG--PSAVSIQAPGSSE 1450
E D +E + + KP G +L P + + +G P+ P +++
Sbjct: 872 EEESDSEEEAETLAQV------KPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 1451 CSGSLGSGIAEVCLWEAGDAP-AIQKAEICPWEL---DDN-------VMGQEMLSLGTGR 1499
SG + G+AP A+ A++ L D N + + T R
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 1500 ESLQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSP--CLDNSSSKA 1557
++ + E +R S E + A Q L+ + T +P + +SS
Sbjct: 986 KA-RASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSK 1044
Query: 1558 GSQFLCNGGSR---ATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSA-QVPRG 1613
S + +G + ATQV P +P T + N+ + + Q +
Sbjct: 1045 ESSRISDGKKQEGPATQVDSAVGTLP---ATSPQSTSVQAKGTNKLRKPKLPEVQQATKA 1101
Query: 1614 GESQKDKEKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDTERPQT 1673
ES D E S + E P+G VGP S + + + +E
Sbjct: 1102 PESSDDSEDSSDSSSGSEEDG-EGPQGAKSAHTLVGPTPS-RTETLVEETAAESSEDDVV 1159
Query: 1674 LLQMSGSVGSKAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPNDTGK 1733
S G + P + + + K + P A ++ G + K G
Sbjct: 1160 APSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQE-AKPQQAAGM 1218
Query: 1734 VSADLGPRERAV-TAPEKPQKP 1754
+S G +E A T P+K +KP
Sbjct: 1219 LSPKTGGKEAASGTTPQKSRKP 1240
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 62.0 bits (149), Expect = 7e-09
Identities = 95/414 (22%), Positives = 153/414 (36%), Gaps = 33/414 (7%)
Query: 1892 SDLPSSMSSEVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTS 1951
+DLPSSM E A+ + +A + G+ P TG ++ K+P E +
Sbjct: 115 ADLPSSMK-EKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
Query: 1952 HELQSVCPWETTAPADSVSHLDRQRPDQPKASSQRLVSTGGRAADVCPWDVPDAGVYKSD 2011
E SV + A VS + +SS G+ + V P V + V +
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS-VKPAQVKASSVSTKE 232
Query: 2012 SSA-KAETCPW---EVTERI------PVKGVSRQDGKGDSQEEKGRAPEKSEPKGVPVQK 2061
S A KA P +VT ++ P K + + + +S EE G E+ P G Q
Sbjct: 233 SPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEE-GSESEEEAPAGTRSQV 291
Query: 2062 KPEMADFRQQEAVCPWESQDGKGLSPQP----APDASDRSRGSSEAAGSVETRVAEVCLW 2117
K + + A P + GKG +P P AS G E + +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 351
Query: 2118 EVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKAGP------GGTEEHFSK 2171
E A + +A+ + GAA +E +G K GP G E S+
Sbjct: 352 ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ 411
Query: 2172 AAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAELCQWEITDPEG 2231
++++ + E P + S G PQ A K SP++ + T P
Sbjct: 412 SSSEESDSEEEAPAQAKPS-GKAPQVRAASAPAKESPRKGAAPAPPRK-------TGPAA 463
Query: 2232 NKIK-GTMADICPGEETGVPSEESGLLALTATRREFFPTAPE-KPLCLLVHGPL 2283
+++ G + S+ L A+ A + + +P+ KP + GPL
Sbjct: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPL 517
Score = 53.9 bits (128), Expect = 2e-06
Identities = 209/1006 (20%), Positives = 352/1006 (34%), Gaps = 171/1006 (16%)
Query: 846 SREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAP-PS 904
+ E A L A + + + ++ EE ++A+A A + RL + L A PS
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAK-----ATPRLASTNSSVLGADLPS 119
Query: 905 PAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPTSTLAPAL 964
K + + +G+ +PHP V+ LSG SP + P+
Sbjct: 120 SMKEKAKAETEKAGKTGNS----MPHPATGKTVAN---LLSGK-------SPRKSAEPSA 165
Query: 965 LPAL-APTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPA 1023
L + T P + P +++ + + E+ G S
Sbjct: 166 NTTLVSETEEEGSVPAFGAAAKPGMVSA------GQADSSSEDTSSSSDETDVEGKPSVK 219
Query: 1024 PARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGS 1083
PA+ + A SV+ ++S A R+A + P+ V+ G+
Sbjct: 220 PAQVK---ASSVSTKESPA-------------RKAAPAPGKVGDVTPQ-------VKGGA 256
Query: 1084 MRSLGLAIKALTRSRSTYREKESVEESPEGQNS-------------------GTAGE--- 1121
+ A K S S+ ES EE+P G S GT G+
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGAT 316
Query: 1122 -----SMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQ 1176
GA + + G+P+ S+ S +ES +++ ++ L + G Q
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSE------SSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 1177 EDRGRRMTQGLGERKAERA--GKTGLAMLRQVS--RDKNIKQSKETPVGWQELPKAGLQS 1232
+ + A A GKTG A+ + + R+++ + S E +E P S
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 1233 LGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAPESRALRQDPGDSQKKRGE 1292
+ R A + ++ A P +T A + + +Q+ DS+ E
Sbjct: 431 GKAPQVRAA--------SAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE-DSRSSSEE 481
Query: 1293 ARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPGSAPQDPGRIRDKSEAGDS 1352
+ E + + + KP + + V P + G L G+ P PG++ A S
Sbjct: 482 SDSDREALAAMNAAQVKP---LGKSPQVKPASTMGMGPLGKGAGPVPPGKV---GPATPS 535
Query: 1353 VEARKVEKPGWEAAGPEAHTPD---ITKAEPCPWEASEGGEDGKPAQEAVKDLPQEKQKT 1409
+ K E+ ++ + + D T P ++ KP K PQ+
Sbjct: 536 AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595
Query: 1410 RKATFWKEQKPGGDLESLCPWESTDFRGPSAVSIQAPGSSECSGSLGSGIAEVCLWEAGD 1469
A K +KP + ES ES+D SA S +AP + + +A
Sbjct: 596 --AVQVKAEKPMDNSES--SEESSD----SADSEEAPAAMTAA-------------QAKP 634
Query: 1470 APAIQKAEICPWELDDNVMGQEMLSLGTGRESLQEKEKA-SRKGSFGEMGEQTVKAVQKL 1528
A I + + CP + + ++ + G ++ ++ A S GS + T + +
Sbjct: 635 ALKIPQTKACP-KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS 693
Query: 1529 SQQQESVCPRESTVPGHSSPCLDNSSSKAGSQFLCNGGSRATQVCPQEDLRPEAQEATPA 1588
S +ES E T G + S G Q +A V + L P
Sbjct: 694 SSSEESDSEEEKT--GLAVTVGQAKSVGKGLQV------KAASVPVKGSLGQGTAPVLPG 745
Query: 1589 KTEICPWEVNERTREEWTSAQVPRGGESQKDKEKMPG-----KSEIEDVTAWEKP---EG 1640
KT +V +E+ S+ E + D E+ K+ ++ A P
Sbjct: 746 KTGPTVTQVKAEKQEDSESS------EEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799
Query: 1641 QIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMSGSVGSKAADICPLDVEENLTAG 1700
K P + V + + Q P + P Q S + A + P + TA
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV-PSVGKAVATAA 858
Query: 1701 KAEICPWEVGAGAGEERALGAE-----AIRKSPNDTGKVSADLGPRERAVTAPEKPQKPT 1755
+A+ P E +G+ EE + E A K T ++ A L P A +P K PT
Sbjct: 859 QAQTGP-EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP---AKESPRKGAAPT 914
Query: 1756 PEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCRPGEV 1801
P G GP A G D G + +E D G P V
Sbjct: 915 PP-------GKTGPSAA--QAGKQDDSGSSS--EESDSDGEAPAAV 949
Score = 46.2 bits (108), Expect = 4e-04
Identities = 198/1022 (19%), Positives = 340/1022 (33%), Gaps = 174/1022 (17%)
Query: 1431 ESTDFRG-PSAVSIQAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMG 1489
+ TD G PS Q SS + + A + GD K P
Sbjct: 208 DETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE 267
Query: 1490 QEMLSLGTGRESLQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPC 1549
+E S G ES +E +R VKA +K+ Q + + P + T ++P
Sbjct: 268 EESESSEEGSESEEEAPAGTRS---------QVKASEKILQVRAASAPAKGTPGKGATPA 318
Query: 1550 LDNSSSKAGSQFLCNGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSAQ 1609
+ SQ ++ +E +++E TPA + + + +T + ++
Sbjct: 319 PPGKAGAVASQTKAGKPEEDSESSSEES--SDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 1610 VPRGGESQKDKEKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDTE 1669
+ + PGK+ A K + +++++ E D +P +
Sbjct: 377 PAKESPRKGAAPAPPGKTG----PAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK 432
Query: 1670 RPQTLLQMSGSVGSKAADICPLDVEENLTAGKAEICPWEVGAGA-----GEERALGAEAI 1724
PQ +AA +E+ G A P + G A G++ +
Sbjct: 433 APQV----------RAASA---PAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSS 479
Query: 1725 RKSPNDTGKVSA-------DLGPRERAVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPG 1777
+S +D ++A LG + A P + P G VGP S G
Sbjct: 480 EESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVG 539
Query: 1778 TLDADGPKAGFQELDHM-GCRPGEVCPWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAG 1836
+ D + + D G P V P + + +AK + KG QKAG
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK------PTSSPAKGPPQKAG 593
Query: 1837 SESAEQR-EKAL---EKGRLTSLGEDVSKGMAKLCQQQETICIWENKDLRESPAQAPKIS 1892
+ + + EK + E +S D + A + Q + + ++ A K +
Sbjct: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL----KIPQTKACPKKTN 649
Query: 1893 DLPSSMSSEVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTSH 1952
S+ + V G +A K P GS P + PA D+ D E+
Sbjct: 650 TTASAKVAPVRVG--TQAPRKAGTATSP-AGSSPAVAGGTQRPAEDSSSSEESDSEEEKT 706
Query: 1953 EL----------------------------QSVCPWETTAPADSVSHLDRQRPDQPKASS 1984
L Q P +V+ + ++ + ++S
Sbjct: 707 GLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSE 766
Query: 1985 QRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWEVTERIP-VKGVSRQDGK--GDS 2041
+ S A+ A V S +A+ P R P KG GK +
Sbjct: 767 EESDSEEAAASP--------AQVKTSVKKTQAKANP--AAARAPSAKGTISAPGKVVTAA 816
Query: 2042 QEEKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPW---------ESQDGK---GLSPQP 2089
+ K R+P K +P PV+ + A P ++Q G S +
Sbjct: 817 AQAKQRSPSKVKP---PVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE 873
Query: 2090 APDASDRSRGSSEAAGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQE--- 2146
D+ + + ++ S +T L E+P A P + G AA+ G+Q+
Sbjct: 874 ESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
Query: 2147 ---RESQGQGE---------------MFL----QKAGPGGTEEHFSKAAAKPR-----EQ 2179
ES GE +F+ AGP T ++AA+ PR E
Sbjct: 934 SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ-AQAASTPRKARASES 992
Query: 2180 EAVCPGEGTGSGGLLPQSGALDPELKVS--------PKEAGSMGSRMAELCQWEITDPEG 2231
A + ++P + L P ++ + P+ A A + +G
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052
Query: 2232 NKIKGTMADICPGEETGVPSEESGLLALTATRREFFPTAPEKPLCLLVHGPLDHFFPESK 2291
K +G + +P ++ L L E P P+ P S
Sbjct: 1053 KKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP-------------PVARTQPSSG 1099
Query: 2292 I-----PCPKVSRPASTFTLEGVRELQGPSGLE-PRTSLAPEPS-LQEAESQSSSLTEDS 2344
+ P S +++ +G +L+ P E + + APE S E S SSS +E+
Sbjct: 1100 VDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEED 1159
Query: 2345 GQ 2346
G+
Sbjct: 1160 GE 1161
Score = 46.2 bits (108), Expect = 4e-04
Identities = 205/1074 (19%), Positives = 357/1074 (33%), Gaps = 163/1074 (15%)
Query: 739 GSPGHGSLPGSSRRRLLSSSLQEPEGTPALHKSRSTYDQRREQDPPLLDSLLRRKLAKKA 798
G+PG G+ P + +S + +S S E++ P +LL+ K + K
Sbjct: 309 GTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKT 368
Query: 799 SRTESRESVEGPPALGFRSASAHNLTVGERLPRARPASLQKSLSVASSREKALLMASQAY 858
S+ + + PA A G+ P A A RE+ SQ+
Sbjct: 369 SQVGAASA----PAKESPRKGAAPAPPGKTGPAVAKAQ-------AGKREED----SQSS 413
Query: 859 LEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSPAKSSSVDSSHTSG 918
EE+ ++E + + A VR SA E PR AP P K+ + G
Sbjct: 414 SEES--DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA--APAPPRKTGPAAAQVQVG 469
Query: 919 RLHEEARRRLPHPPI-RHQVSTPILALSGGLGEPRMLSPTSTLAPALL-PALAPTPAPAL 976
+ E++R R ++ A LG+ + P ST+ L P P
Sbjct: 470 KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP---- 525
Query: 977 APVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPAPARARLWRALSVA 1036
P V P +P+ + WE + +E+ P A++ A
Sbjct: 526 -PGKVGPATPS--AQVGKWEEDSESSSEESSDSSDGEVP---------------TAVAPA 567
Query: 1037 VEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGSMRSLGLAIKALTR 1096
EKS N + A+ P S K P Q+ + +
Sbjct: 568 QEKSLG--NILQAK-------------------PTSSPAKGPPQKAG------PVAVQVK 600
Query: 1097 SRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQ 1156
+ ES EES + +S A +M A P L P Q P
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIP-----QTKACP---------- 645
Query: 1157 QNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAMLRQVSRDKNIKQSK 1216
+ +T+ +V + + T G A G ++ + D + +
Sbjct: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG------TQRPAEDSSSSEES 699
Query: 1217 ETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAPES 1276
++ E K GL V + + + A + P +T +
Sbjct: 700 DS-----EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754
Query: 1277 RALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPGSA 1336
+A +Q+ +S ++ ++ + V KK + A P SA +PG
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP--SAKGTISAPGKV 812
Query: 1337 PQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEPCPWEASEGGEDGKPAQ 1396
+ + +S + R + A GP A P + KA +A G E+ +
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP-ASVPSVGKAVATAAQAQTGPEEDSGSS 871
Query: 1397 EAVKDLPQEKQKTRKATFWKEQKPGGDLE----SLCPWESTDFRG--PSAVSIQAPGSSE 1450
E D +E + + KP G +L P + + +G P+ P +++
Sbjct: 872 EEESDSEEEAETLAQV------KPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 1451 CSGSLGSGIAEVCLWEAGDAP-AIQKAEICPWEL---DDN-------VMGQEMLSLGTGR 1499
SG + G+AP A+ A++ L D N + + T R
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 1500 ESLQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSP--CLDNSSSKA 1557
++ + E +R S E + A Q L+ + T +P + +SS
Sbjct: 986 KA-RASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSK 1044
Query: 1558 GSQFLCNGGSR---ATQV---------CPQEDLRPEAQEATPAKTEICPWEVNE------ 1599
S + +G + ATQV Q L+ AQ+A+ A+ + + +
Sbjct: 1045 ESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAV 1104
Query: 1600 ----RTREEWTSAQVPRGGESQKDK----EKMPGKSEIEDVTAWEKPEGQIQKQEAVGPW 1651
T + TS Q + +K K ++ E D + +++ GP
Sbjct: 1105 GTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQ 1164
Query: 1652 ESVDPGSFSPQPRPQDTERPQTLLQMSGS----------VGSKAADICPLDVEENLTAGK 1701
+ + P P +T +T + S G + P + + + K
Sbjct: 1165 GAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPK 1224
Query: 1702 AEICPWEVGAGAGEERALGAEAIRKSPNDTGKVSADLGPRERAV-TAPEKPQKP 1754
+ P A ++ G + K G +S G +E A T P+K +KP
Sbjct: 1225 LDSSPSVSSTLAAKDDPDGKQE-AKPQQAAGMLSPKTGGKEAASGTTPQKSRKP 1277
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 62.0 bits (149), Expect = 7e-09
Identities = 95/414 (22%), Positives = 153/414 (36%), Gaps = 33/414 (7%)
Query: 1892 SDLPSSMSSEVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTS 1951
+DLPSSM E A+ + +A + G+ P TG ++ K+P E +
Sbjct: 115 ADLPSSMK-EKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
Query: 1952 HELQSVCPWETTAPADSVSHLDRQRPDQPKASSQRLVSTGGRAADVCPWDVPDAGVYKSD 2011
E SV + A VS + +SS G+ + V P V + V +
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS-VKPAQVKASSVSTKE 232
Query: 2012 SSA-KAETCPW---EVTERI------PVKGVSRQDGKGDSQEEKGRAPEKSEPKGVPVQK 2061
S A KA P +VT ++ P K + + + +S EE G E+ P G Q
Sbjct: 233 SPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEE-GSESEEEAPAGTRSQV 291
Query: 2062 KPEMADFRQQEAVCPWESQDGKGLSPQP----APDASDRSRGSSEAAGSVETRVAEVCLW 2117
K + + A P + GKG +P P AS G E + +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 351
Query: 2118 EVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKAGP------GGTEEHFSK 2171
E A + +A+ + GAA +E +G K GP G E S+
Sbjct: 352 ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ 411
Query: 2172 AAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAELCQWEITDPEG 2231
++++ + E P + S G PQ A K SP++ + T P
Sbjct: 412 SSSEESDSEEEAPAQAKPS-GKAPQVRAASAPAKESPRKGAAPAPPRK-------TGPAA 463
Query: 2232 NKIK-GTMADICPGEETGVPSEESGLLALTATRREFFPTAPE-KPLCLLVHGPL 2283
+++ G + S+ L A+ A + + +P+ KP + GPL
Sbjct: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPL 517
Score = 58.9 bits (141), Expect = 6e-08
Identities = 300/1477 (20%), Positives = 504/1477 (34%), Gaps = 278/1477 (18%)
Query: 846 SREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAP-PS 904
+ E A L A + + + ++ EE ++A+A A + RL + L A PS
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAK-----ATPRLASTNSSVLGADLPS 119
Query: 905 PAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPTSTLAPAL 964
K + + +G+ +PHP V+ LSG SP + P+
Sbjct: 120 SMKEKAKAETEKAGKTGNS----MPHPATGKTVAN---LLSGK-------SPRKSAEPSA 165
Query: 965 LPAL-APTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPA 1023
L + T P + P +++ + + E+ G S
Sbjct: 166 NTTLVSETEEEGSVPAFGAAAKPGMVSA------GQADSSSEDTSSSSDETDVEGKPSVK 219
Query: 1024 PARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGS 1083
PA+ + A SV+ ++S A R+A + P+ V+ G+
Sbjct: 220 PAQVK---ASSVSTKESPA-------------RKAAPAPGKVGDVTPQ-------VKGGA 256
Query: 1084 MRSLGLAIKALTRSRSTYREKESVEESPEGQNS-------------------GTAGE--- 1121
+ A K S S+ ES EE+P G S GT G+
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGAT 316
Query: 1122 -----SMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQ 1176
GA + + G+P+ S+ S +ES +++ ++ L + G Q
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSE------SSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 1177 EDRGRRMTQGLGERKAERA--GKTGLAMLRQVS--RDKNIKQSKETPVGWQELPKAGLQS 1232
+ + A A GKTG A+ + + R+++ + S E +E P S
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 1233 LGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAPESRALRQDPGDSQKKRGE 1292
+ R A + ++ A P +T A + + +Q+ DS+ E
Sbjct: 431 GKAPQVRAA--------SAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE-DSRSSSEE 481
Query: 1293 ARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPGSAPQDPGRIRDKSEAGDS 1352
+ E + + + KP + + V P + G L G+ P PG++ A S
Sbjct: 482 SDSDREALAAMNAAQVKP---LGKSPQVKPASTMGMGPLGKGAGPVPPGKV---GPATPS 535
Query: 1353 VEARKVEKPGWEAAGPEAHTPD---ITKAEPCPWEASEGGEDGKPAQEAVKDLPQEKQKT 1409
+ K E+ ++ + + D T P ++ KP K PQ+
Sbjct: 536 AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595
Query: 1410 RKATFWKEQKPGGDLESLCPWESTDFRGPSAVSIQAPGSSECSGSLGSGIAEVCLWEAGD 1469
A K +KP + ES ES+D SA S +AP + + +A
Sbjct: 596 --AVQVKAEKPMDNSES--SEESSD----SADSEEAPAAMTAA-------------QAKP 634
Query: 1470 APAIQKAEICPWELDDNVMGQEMLSLGTGRESLQEKEKA-SRKGSFGEMGEQTVKAVQKL 1528
A I + + CP + + ++ + G ++ ++ A S GS + T + +
Sbjct: 635 ALKIPQTKACP-KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS 693
Query: 1529 SQQQESVCPRESTVPGHSSPCLDNSSSKAGSQFLCNGGSRATQVCPQEDLRPEAQEATPA 1588
S +ES E T G + S G Q +A V + L P
Sbjct: 694 SSSEESDSEEEKT--GLAVTVGQAKSVGKGLQV------KAASVPVKGSLGQGTAPVLPG 745
Query: 1589 KTEICPWEVNERTREEWTSAQVPRGGESQKDKEKMPG-----KSEIEDVTAWEKP---EG 1640
KT +V +E+ S+ E + D E+ K+ ++ A P
Sbjct: 746 KTGPTVTQVKAEKQEDSESS------EEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799
Query: 1641 QIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMSGSVGSKAADICPLDVEENLTAG 1700
K P + V + + Q P + P Q S + A + P + TA
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV-PSVGKAVATAA 858
Query: 1701 KAEICPWEVGAGAGEERALGAE-----AIRKSPNDTGKVSADLGPRERAVTAPEKPQKPT 1755
+A+ P E +G+ EE + E A K T ++ A L P A +P K PT
Sbjct: 859 QAQTGP-EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP---AKESPRKGAAPT 914
Query: 1756 PEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCRPGEV-------------- 1801
P G GP A G D G + +E D G P V
Sbjct: 915 PP-------GKTGPSAA--QAGKQDDSGSSS--EESDSDGEAPAAVTSAQVIKPPLIFVD 963
Query: 1802 ----------CPWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGR 1851
P +AQ A+T KA+ + +T + ++ E + L G
Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKAR------ASESTARSSSSESEDEDVIPATQCLTPGI 1017
Query: 1852 LTSLGE--------DVSKGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVA 1903
T++ MA +E+ I + K +E P A ++ ++ +
Sbjct: 1018 RTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKK-QEGP--ATQVDSAVGTLPATSP 1074
Query: 1904 EGHSLEATEKGDLRQDPKTGSFPEHITQEKAP--------AADTEEFTTEDGE-----KT 1950
+ S++A LR+ PK PE KAP ++D+ + EDGE K+
Sbjct: 1075 QSTSVQAKGTNKLRK-PK---LPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKS 1130
Query: 1951 SHELQSVCPWETTAPADSVSHLDRQRPDQPKASSQRLVS---------TGGRAADVCPW- 2000
+H L T ++ + D A SQ L+S +A+ P
Sbjct: 1131 AHTLGPTPSRTETLVEETAA---ESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKL 1187
Query: 2001 ----DVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGDSQEEKGRAPEKSEPKG 2056
V K D K E P + + K ++ G + +K R P+K
Sbjct: 1188 DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG-TTPQKSRKPKKG---- 1242
Query: 2057 VPVQKKPEMADFRQQEAVC------PWESQDGK----------GLSPQPAPDASDRSRGS 2100
P+ + Q + PW + + L Q D ++ S
Sbjct: 1243 ---AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKES 1299
Query: 2101 SEAAGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKA 2160
S R S KK ++ E GG A ++ + +G+ KA
Sbjct: 1300 SRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGE--GGEASVSPEKTSTTSKGKAKRDKA 1357
Query: 2161 GPGGTEEHFSKAA-----AKPREQEAVCPGEGTGSGG 2192
G +E K + AK +E + G GT GG
Sbjct: 1358 S-GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGG 1393
Score = 50.8 bits (120), Expect = 2e-05
Identities = 190/997 (19%), Positives = 334/997 (33%), Gaps = 177/997 (17%)
Query: 739 GSPGHGSLPGSSRRRLLSSSLQEPEGTPALHKSRSTYDQRREQDPPLLDSLLRRKLAKKA 798
G+PG G+ P + +S + +S S E++ P +LL+ K + K
Sbjct: 309 GTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKT 368
Query: 799 SRTESRESVEGPPALGFRSASAHNLTVGERLPRARPASLQKSLSVASSREKALLMASQAY 858
S+ + + PA A G+ P A A RE+ SQ+
Sbjct: 369 SQVGAASA----PAKESPRKGAAPAPPGKTGPAVAKAQ-------AGKREED----SQSS 413
Query: 859 LEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSPAKSSSVDSSHTSG 918
EE+ ++E + + A VR SA E PR AP P K+ + G
Sbjct: 414 SEES--DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA--APAPPRKTGPAAAQVQVG 469
Query: 919 RLHEEARRRLPHPPI-RHQVSTPILALSGGLGEPRMLSPTSTLAPALL-PALAPTPAPAL 976
+ E++R R ++ A LG+ + P ST+ L P P
Sbjct: 470 KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP---- 525
Query: 977 APVPVSPQSPNLLTYICPWE--------------NAELPAKQENVPQEGPSGPERGHHSP 1022
P V P +P+ + WE + E+P ++ + +
Sbjct: 526 -PGKVGPATPS--AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS 582
Query: 1023 APARARLWRALSVAV--------EKSRAGENEMDAEDAHHQREANDVDEDRP-------K 1067
+PA+ +A VAV + S + E D+ D+ A + +P K
Sbjct: 583 SPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK 642
Query: 1068 IFPK-----SHSLKAPVQQGSM--RSLGLAIKALTRSRSTY-REKESVEESPEGQNSGTA 1119
PK + + APV+ G+ R G A S + + E+S + S +
Sbjct: 643 ACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSE 702
Query: 1120 GESMGAPSRSPRLGRPKAVSK----QAALIP----------------------------S 1147
E G + +G+ K+V K +AA +P
Sbjct: 703 EEKTGL---AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQ 759
Query: 1148 DDKESLQ----NQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAML 1203
+D ES + +++ A + ++ ++ + R G A T A
Sbjct: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA 819
Query: 1204 RQVSRDKNIKQSKETPVGWQELPK--AGLQSLGS--ADHRVAEVCPWEVTESETRQPDSG 1259
+Q S K +K P L + A + S+G A A+ P E + S + DS
Sbjct: 820 KQRSPSK-VKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE 878
Query: 1260 NKAEICPWETSEGAPESRALRQDPGDSQKKRGEA---RGKSEPIDVVPMMRKKPERLVRE 1316
+AE G P ++G A GK+ P + ++
Sbjct: 879 EEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP---------SAAQAGKQ 929
Query: 1317 QEAVCPWESADRGG------------------LSPGSAPQDPGRIRDKSEAGDSVEARKV 1358
++ E +D G + P +P P +++A + +
Sbjct: 930 DDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARA 989
Query: 1359 EKPGWEAAGPEAHTPDITKAEPCPWEASEGGEDGKPA-------QEAVKDLPQEKQKTRK 1411
+ ++ E+ D+ A C P + ++ K+ +R
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 1412 ATFWKEQKPGGDLESLCPWESTDFRGPSAVSIQAPGSSECSGSLGSGIAEVCLWEAGDAP 1471
+ K++ P ++S + P + S+QA G+++ P
Sbjct: 1050 SDGKKQEGPATQVDSAV--GTLPATSPQSTSVQAKGTNKL--------------RKPKLP 1093
Query: 1472 AIQKAEICPWELDDNVMGQEMLS-LGTGRESLQEKEKASRKGSFGEMGEQTVKAVQKLSQ 1530
+Q+A P DD+ + S E Q + A G E V+ S
Sbjct: 1094 EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESS 1153
Query: 1531 QQESVCPRESTVPGHSSPCLDNSSSKAGSQFLCNGGSRATQVCPQEDLRPEAQEATPAKT 1590
+ + V P +S + G+ +P L ++S+A S+AT P+ D P AK
Sbjct: 1154 EDDVVAPSQSLLSGYMTPGLTPANSQA---------SKAT---PKLDSSPSVSSTLAAKD 1201
Query: 1591 EICPWEVNERTREEWTSAQVPRGGESQKDKEKMPGKS 1627
+ P E ++ P+ G + P KS
Sbjct: 1202 D--PDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKS 1236
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c [Homo
sapiens]
Length = 958
Score = 62.0 bits (149), Expect = 7e-09
Identities = 95/414 (22%), Positives = 153/414 (36%), Gaps = 33/414 (7%)
Query: 1892 SDLPSSMSSEVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTS 1951
+DLPSSM E A+ + +A + G+ P TG ++ K+P E +
Sbjct: 115 ADLPSSMK-EKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
Query: 1952 HELQSVCPWETTAPADSVSHLDRQRPDQPKASSQRLVSTGGRAADVCPWDVPDAGVYKSD 2011
E SV + A VS + +SS G+ + V P V + V +
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS-VKPAQVKASSVSTKE 232
Query: 2012 SSA-KAETCPW---EVTERI------PVKGVSRQDGKGDSQEEKGRAPEKSEPKGVPVQK 2061
S A KA P +VT ++ P K + + + +S EE G E+ P G Q
Sbjct: 233 SPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEE-GSESEEEAPAGTRSQV 291
Query: 2062 KPEMADFRQQEAVCPWESQDGKGLSPQP----APDASDRSRGSSEAAGSVETRVAEVCLW 2117
K + + A P + GKG +P P AS G E + +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 351
Query: 2118 EVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKAGP------GGTEEHFSK 2171
E A + +A+ + GAA +E +G K GP G E S+
Sbjct: 352 ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ 411
Query: 2172 AAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAELCQWEITDPEG 2231
++++ + E P + S G PQ A K SP++ + T P
Sbjct: 412 SSSEESDSEEEAPAQAKPS-GKAPQVRAASAPAKESPRKGAAPAPPRK-------TGPAA 463
Query: 2232 NKIK-GTMADICPGEETGVPSEESGLLALTATRREFFPTAPE-KPLCLLVHGPL 2283
+++ G + S+ L A+ A + + +P+ KP + GPL
Sbjct: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPL 517
Score = 56.6 bits (135), Expect = 3e-07
Identities = 211/1015 (20%), Positives = 357/1015 (35%), Gaps = 171/1015 (16%)
Query: 846 SREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAP-PS 904
+ E A L A + + + ++ EE ++A+A A + RL + L A PS
Sbjct: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAK-----ATPRLASTNSSVLGADLPS 119
Query: 905 PAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPTSTLAPAL 964
K + + +G+ +PHP V+ LSG SP + P+
Sbjct: 120 SMKEKAKAETEKAGKTGNS----MPHPATGKTVAN---LLSGK-------SPRKSAEPSA 165
Query: 965 LPAL-APTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPA 1023
L + T P + P +++ + + E+ G S
Sbjct: 166 NTTLVSETEEEGSVPAFGAAAKPGMVSA------GQADSSSEDTSSSSDETDVEGKPSVK 219
Query: 1024 PARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGS 1083
PA+ + A SV+ ++S A R+A + P+ V+ G+
Sbjct: 220 PAQVK---ASSVSTKESPA-------------RKAAPAPGKVGDVTPQ-------VKGGA 256
Query: 1084 MRSLGLAIKALTRSRSTYREKESVEESPEGQNS-------------------GTAGE--- 1121
+ A K S S+ ES EE+P G S GT G+
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGAT 316
Query: 1122 -----SMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQ 1176
GA + + G+P+ S+ S +ES +++ ++ L + G Q
Sbjct: 317 PAPPGKAGAVASQTKAGKPEEDSE------SSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 1177 EDRGRRMTQGLGERKAERA--GKTGLAMLRQVS--RDKNIKQSKETPVGWQELPKAGLQS 1232
+ + A A GKTG A+ + + R+++ + S E +E P S
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 1233 LGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAPESRALRQDPGDSQKKRGE 1292
+ R A + ++ A P +T A + + +Q+ DS+ E
Sbjct: 431 GKAPQVRAA--------SAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE-DSRSSSEE 481
Query: 1293 ARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPGSAPQDPGRIRDKSEAGDS 1352
+ E + + + KP + + V P + G L G+ P PG++ A S
Sbjct: 482 SDSDREALAAMNAAQVKP---LGKSPQVKPASTMGMGPLGKGAGPVPPGKV---GPATPS 535
Query: 1353 VEARKVEKPGWEAAGPEAHTPD---ITKAEPCPWEASEGGEDGKPAQEAVKDLPQEKQKT 1409
+ K E+ ++ + + D T P ++ KP K PQ+
Sbjct: 536 AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595
Query: 1410 RKATFWKEQKPGGDLESLCPWESTDFRGPSAVSIQAPGSSECSGSLGSGIAEVCLWEAGD 1469
A K +KP + ES ES+D SA S +AP + + +A
Sbjct: 596 --AVQVKAEKPMDNSES--SEESSD----SADSEEAPAAMTAA-------------QAKP 634
Query: 1470 APAIQKAEICPWELDDNVMGQEMLSLGTGRESLQEKEKA-SRKGSFGEMGEQTVKAVQKL 1528
A I + + CP + + ++ + G ++ ++ A S GS + T + +
Sbjct: 635 ALKIPQTKACP-KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS 693
Query: 1529 SQQQESVCPRESTVPGHSSPCLDNSSSKAGSQFLCNGGSRATQVCPQEDLRPEAQEATPA 1588
S +ES E T G + S G Q +A V + L P
Sbjct: 694 SSSEESDSEEEKT--GLAVTVGQAKSVGKGLQV------KAASVPVKGSLGQGTAPVLPG 745
Query: 1589 KTEICPWEVNERTREEWTSAQVPRGGESQKDKEKMPG-----KSEIEDVTAWEKP---EG 1640
KT +V +E+ S+ E + D E+ K+ ++ A P
Sbjct: 746 KTGPTVTQVKAEKQEDSESS------EEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799
Query: 1641 QIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMSGSVGSKAADICPLDVEENLTAG 1700
K P + V + + Q P + P Q S + A + P + TA
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV-PSVGKAVATAA 858
Query: 1701 KAEICPWEVGAGAGEERALGAE-----AIRKSPNDTGKVSADLGPRERAVTAPEKPQKPT 1755
+A+ P E +G+ EE + E A K T ++ A L P A +P K PT
Sbjct: 859 QAQTGP-EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP---AKESPRKGAAPT 914
Query: 1756 PEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGCRPGEVCPWEAQEAA 1810
P G GP A G D G + +E D G P V + QE++
Sbjct: 915 PP-------GKTGPSAA--QAGKQDDSGSSS--EESDSDGEAPAAVTSAQDQESS 958
Score = 44.7 bits (104), Expect = 0.001
Identities = 144/742 (19%), Positives = 245/742 (33%), Gaps = 111/742 (14%)
Query: 739 GSPGHGSLPGSSRRRLLSSSLQEPEGTPALHKSRSTYDQRREQDPPLLDSLLRRKLAKKA 798
G+PG G+ P + +S + +S S E++ P +LL+ K + K
Sbjct: 309 GTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKT 368
Query: 799 SRTESRESVEGPPALGFRSASAHNLTVGERLPRARPASLQKSLSVASSREKALLMASQAY 858
S+ + + PA A G+ P A A RE+ SQ+
Sbjct: 369 SQVGAASA----PAKESPRKGAAPAPPGKTGPAVAKAQ-------AGKREED----SQSS 413
Query: 859 LEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSPAKSSSVDSSHTSG 918
EE+ ++E + + A VR SA E PR AP P K+ + G
Sbjct: 414 SEES--DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA--APAPPRKTGPAAAQVQVG 469
Query: 919 RLHEEARRRLPHPPI-RHQVSTPILALSGGLGEPRMLSPTSTLAPALL-PALAPTPAPAL 976
+ E++R R ++ A LG+ + P ST+ L P P
Sbjct: 470 KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP---- 525
Query: 977 APVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPAPARARLWRALSVA 1036
P V P +P+ + WE + +E+ P A++ A
Sbjct: 526 -PGKVGPATPS--AQVGKWEEDSESSSEESSDSSDGEVP---------------TAVAPA 567
Query: 1037 VEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGSMRSLGLAIKALTR 1096
EKS N + A+ P S K P Q+ + +
Sbjct: 568 QEKSLG--NILQAK-------------------PTSSPAKGPPQKAG------PVAVQVK 600
Query: 1097 SRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQ 1156
+ ES EES + +S A +M A P L P Q P
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIP-----QTKACP---------- 645
Query: 1157 QNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAMLRQVSRDKNIKQSK 1216
+ +T+ +V + + T G A G ++ + D + +
Sbjct: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG------TQRPAEDSSSSEES 699
Query: 1217 ETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAPES 1276
++ E K GL V + + + A + P +T +
Sbjct: 700 DS-----EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754
Query: 1277 RALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPGSA 1336
+A +Q+ +S ++ ++ + V KK + A P SA +PG
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAP--SAKGTISAPGKV 812
Query: 1337 PQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEPCPWEASEGGEDGKPAQ 1396
+ + +S + R + A GP A P + KA +A G E+ +
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP-ASVPSVGKAVATAAQAQTGPEEDSGSS 871
Query: 1397 EAVKDLPQEKQKTRKATFWKEQKPGGDLE----SLCPWESTDFRG--PSAVSIQAPGSSE 1450
E D +E + + KP G +L P + + +G P+ P +++
Sbjct: 872 EEESDSEEEAETLAQV------KPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 1451 CSGSLGSGIAEVCLWEAGDAPA 1472
SG + G+APA
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPA 947
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 62.0 bits (149), Expect = 7e-09
Identities = 349/1739 (20%), Positives = 574/1739 (33%), Gaps = 222/1739 (12%)
Query: 640 EEMVDEVCEDELDLQHSGSYLGSSIASAWSEHSLDPGDIRDELKKLYAQLEVHKTKEMAA 699
EEM++E +E +Q + + E ++PG + + A E H+ E+
Sbjct: 74 EEMMEEQGYEEQQIQEKVATFRLMLL----EKDVNPGGKEETPGQRPAVTETHQLAELNE 129
Query: 700 NNPHLPKKRGSSCQGLGRSFMRYLAEFPEALARQHSRDSGSPGHGSLPGSSRRRLLSSSL 759
+R + G+ S++ + P+ AR+ + + P P S R SSS
Sbjct: 130 KK----NERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPK---PYSLVRE--SSSS 180
Query: 760 QEPEGTPALHKSRSTYDQRREQDPPLLDSLLRRKLAKKASRTESRESVEGPPALGFRSAS 819
+ P K + +R E P + K K S +ES++ P + S
Sbjct: 181 RSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKS 240
Query: 820 AHNLTVGER----LPRARPASLQKSLSVASSRE--KALLMASQAYLEETYRQAKEREERK 873
R P++R A S ASS + ++ ++ A T +
Sbjct: 241 KDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPAS 300
Query: 874 KAKAAMASLVRRPSARRLERPRGAPLSA--PPSPAKSSSVDSSHTSGRLHEEARRRL--- 928
+ + P +RP + P SP + D S + R
Sbjct: 301 GRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTG 360
Query: 929 PHPPIRHQVSTPILALSGGLGEPRMLSPTSTLAPALLPALAPTPAPALAPVPVSPQSPNL 988
P PP TP+LA G G P+ L+ T + P +P +P P+SP
Sbjct: 361 PEPP----APTPLLAERHG-GSPQPLATTPLSQEPVNPPSEASPTRDRSP----PKSPEK 411
Query: 989 LTYICPWENAELPAKQENVPQEGPSGPERGHHSPAPARARLWRALSVAVEKSRAGENEMD 1048
L E++ + V + S PE +PAP R + S +N
Sbjct: 412 LPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHR-------EISSSPTSKNRS- 463
Query: 1049 AEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYREKESVE 1108
H R D KSHS + G RS A + +RSR+ + S
Sbjct: 464 -----HGRAKRD----------KSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRS 508
Query: 1109 ESPEGQNSGTA---GESMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHTSRML 1165
SP+ + S +A G S +P R R P+ + S ++ SR
Sbjct: 509 RSPQWRRSRSAQRWGRSR-SPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSP 567
Query: 1166 QVCQREGSREQEDRGRRMTQGLGERKA------ERAGKTGLAMLRQVSRDKNIKQSK--- 1216
R SR RGR ++ R++ R ++ R SR + + +
Sbjct: 568 ATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRT 627
Query: 1217 ETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAPES 1276
+PV + ++ + G + R P S +R P ++ G S
Sbjct: 628 RSPVRRRSRSRSPARRSGRSRSRT----PARRGRSRSRTPARRGRSRSRTPARRSGRSRS 683
Query: 1277 RALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPGSA 1336
R + + R RG+S +V R R + E ++ S +
Sbjct: 684 RTPAR--RGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRS 741
Query: 1337 PQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEPCPWEASEGGEDGKPAQ 1396
+ KS S +R + P +A + ++ + PCP + S+ P +
Sbjct: 742 RSNSSPEMKKSRI-SSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQ-----TPPR 795
Query: 1397 EAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFRGPSAVSIQAPGSSECSGSLG 1456
+ Q K K+R P S P + PS Q+ SS +
Sbjct: 796 RSRSGSSQPKAKSR-------TPPRRSRSSSSPPPKQKSKTPSR---QSHSSSSPHPKVK 845
Query: 1457 SGI----AEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTGRESLQEKEKAS--- 1509
SG + +A + + C D + S + S + K+S
Sbjct: 846 SGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPP 905
Query: 1510 -RKGSFGEMGEQTVKAVQKLSQQQE--SVCPRESTVPGHSSPCLDNSSSKAGS--QFLCN 1564
+ S + VKA+ Q+ S P S V ++P S S + L
Sbjct: 906 RQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLP 965
Query: 1565 GGSRATQVCPQEDLRPEAQEATPAKTEICPW-EVNERT--REEWTSAQVPRGGESQKDK- 1620
S + P ++PE I P+ +V +T + ++ P E KD
Sbjct: 966 RYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSL 1025
Query: 1621 -EKMPGKSEIEDVTAWEKPEG---------QIQKQEAVGPWESVDPGSFSPQPRPQDTER 1670
+ PG + P G Q++ Q P D + SP+ R +E
Sbjct: 1026 VQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSD--TSSPEVRQSHSES 1083
Query: 1671 PQTLLQMSGS-VGSKAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPN 1729
P + S G ++ P V E + E A + + E R +
Sbjct: 1084 PSLQSKSQTSPKGGRSRSSSP--VTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSD 1141
Query: 1730 DTGKVSAD---LGPRERAVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADGPKA 1786
+ + D L + R TA K + P E A S P D P++
Sbjct: 1142 SSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFP---VQDRPES 1198
Query: 1787 GFQELDHMGCRPGE---------------VCPWEAQEAATSEKAKICPWEVSEGTTGKGL 1831
D + P E P +Q+ E + + +
Sbjct: 1199 SLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSS 1258
Query: 1832 DQKAGSESAEQREKALEKGRLTSLGEDVSKGMAKLCQQQETICIWENKDLRESPAQAPKI 1891
+ K S S + +E+ SL D S+ A L E + + P +P+
Sbjct: 1259 ELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASL----EAVEVPSMASSWGGPHFSPEH 1314
Query: 1892 SDLPSSMSSEVAEGHSLEATEKGDLRQDPKTGSFPEHITQ----------EKAPAADTEE 1941
+L +S E + G LE G L + TG F + + E P+ D +E
Sbjct: 1315 KELSNSPLRENSFGSPLEFRNSGPLGTEMNTG-FSSEVKEDLNGPFLNQLETDPSLDMKE 1373
Query: 1942 FTTEDGEKTSHEL-------------QSV-------CPWETTAPADSVSHLDRQRPDQPK 1981
+T +S EL QS+ P + S + + P+
Sbjct: 1374 QSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPR 1433
Query: 1982 ASSQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKGDS 2041
S+R S G + + + S SS + P R P +G S D
Sbjct: 1434 TPSRR--SRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIP-----RTPSRGRSECD----- 1481
Query: 2042 QEEKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGSS 2101
EPK +P +P R + P + K L+PQ R R S
Sbjct: 1482 --------SSPEPKALPQTPRP-----RSRSPSSP--ELNNKCLTPQ-------RERSGS 1519
Query: 2102 EAAGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFL-QKA 2160
E++ +T VA L + + S+++ ++ P A E + +S+ + L Q++
Sbjct: 1520 ESSVDQKT-VARTPLGQRSRSGSSQELDVKP-SASPQERSESDSSPDSKAKTRTPLRQRS 1577
Query: 2161 GPGGTEEHFSKAAAKPREQEAVCPGEGTGSGGLLP--QSGA-LDPELKVSPKEAGSMGSR 2217
G + E SK+ PR + E P QSG+ PE K A SR
Sbjct: 1578 RSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSR 1637
Query: 2218 MAELCQWEITDPEGNKIKGTMADICPGEET----GVPSEESGLLALTATRREFFPTAPE 2272
+ PEG+ + + P T S E + T RR ++PE
Sbjct: 1638 SGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPE 1696
Score = 48.5 bits (114), Expect = 8e-05
Identities = 114/536 (21%), Positives = 178/536 (33%), Gaps = 107/536 (19%)
Query: 696 EMAANNPHLPKKRGSSCQGLGRSFMRYLAEFPEALARQHSRDSGSPGHGSLPGS-SRRRL 754
EM P P +R S G +R + P +HS SPG +P + SR R
Sbjct: 1426 EMKDGLPRTPSRRSRSGSSPG---LRDGSGTPS----RHSLSGSSPGMKDIPRTPSRGRS 1478
Query: 755 LSSSLQEPEGTPALHKSRSTYDQRREQDPPLLDSLLRRKLAKKASRTESRESVEGPPALG 814
S EP+ P + RS R P L + L + + S + + LG
Sbjct: 1479 ECDSSPEPKALPQTPRPRS----RSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLG 1534
Query: 815 FRSASAHNLTVGERLPRARPASLQKSLSVASSREKALLMASQAYLEETYRQAKEREERKK 874
RS S + + + P A P +S S S+ K ++ L + R E K
Sbjct: 1535 QRSRSGSSQELDVK-PSASPQERSESDSSPDSKAK-----TRTPLRQRSRSGSSPEVDSK 1588
Query: 875 AKAAMASLVRRPSARRLERPRGAPLSAPPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIR 934
++ + S ++PR AP + S DSS P P
Sbjct: 1589 SRLSPRRSRSGSSPEVKDKPRAAPRA-------QSGSDSS--------------PEPKAP 1627
Query: 935 HQVSTPILALSGGLGEPRMLSPTSTLAPALLPALAPTPAPALAPVPVSPQSPNLLTYICP 994
+ P + SG + R SP + + P
Sbjct: 1628 APRALPRRSRSGSSSKGRGPSPEGSSSTESSP---------------------------- 1659
Query: 995 WENAELPAKQENVPQEGPSGPERGHHSPAPARARLWRALSVAVEKSRAGENEMDAEDAHH 1054
E P K + S PE S P R R R+ K+R A +
Sbjct: 1660 ----EHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPE 1715
Query: 1055 QREANDVDEDRPKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYREKESVEESPEGQ 1114
R P +S S+ +P + +SRS+ R + + SP +
Sbjct: 1716 TRSRT------PPRHRRSPSVSSP-------------EPAEKSRSSRRRRSA--SSPRTK 1754
Query: 1115 NSGTAGESMGAPSRSPR-LGRPKAVSKQAALIPSDDKESLQNQQNAHTSRMLQVCQREGS 1173
+ G S PS PR L R ++ S++ + ++ + Q+ R QR S
Sbjct: 1755 TTSRRGRS---PSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRR-----QRSRS 1806
Query: 1174 REQEDRGRRMTQGLGERKAERAGKTGLAMLRQVSR------DKNIKQSKETPVGWQ 1223
R + R RR G R R + + R+ R + +S+ +P W+
Sbjct: 1807 RSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWK 1862
Score = 38.9 bits (89), Expect = 0.061
Identities = 103/518 (19%), Positives = 174/518 (33%), Gaps = 66/518 (12%)
Query: 861 ETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSPAKSSSVDSSHTSGRL 920
ET +E+ ++ +S + + + +S+P A + +S
Sbjct: 1364 ETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSAS 1423
Query: 921 HEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPTSTLAPALLPALAPTPAPALAPVP 980
E + LP P R S L G G P S S +P + + TP+ +
Sbjct: 1424 SPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHS-LSGSSPG-MKDIPRTPSRGRSECD 1481
Query: 981 VSPQSPNLLTYICPWENAELPAKQEN---VPQEGPSGPERGHHSPAPARARLWRALSVAV 1037
SP+ L P + + N PQ SG E AR L
Sbjct: 1482 SSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLG------- 1534
Query: 1038 EKSRAGEN-EMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGS---MRSLGLAIKA 1093
++SR+G + E+D + + +E ++ D L+ + GS + S
Sbjct: 1535 QRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPR 1594
Query: 1094 LTRSRSTYREKESVEESPEGQNSGTAGESMGAPS--RSPRLGRPKAVSKQAALIPSDDKE 1151
+RS S+ K+ +P Q+ + AP+ PR R + SK P
Sbjct: 1595 RSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSS 1654
Query: 1152 SLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAMLRQVSRDKN 1211
+ + ++ SR R GSR + + ++ R++ R+ R R ++
Sbjct: 1655 TESSPEHPPKSR----TARRGSRSSPE-PKTKSRTPPRRRSSRSSPELTRKARLSRRSRS 1709
Query: 1212 IKQSKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSE 1271
S ET +S HR P+ K+ S
Sbjct: 1710 ASSSPET------------RSRTPPRHR---------RSPSVSSPEPAEKSRSSRRRRSA 1748
Query: 1272 GAPESRAL-RQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGG 1330
+P ++ R+ S K RG R +S R++ R R + DR G
Sbjct: 1749 SSPRTKTTSRRGRSPSPKPRGLQRSRSR-------SRREKTRTTRRR---------DRSG 1792
Query: 1331 LSPGSAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGP 1368
S Q R R +S + V R+ G+ + P
Sbjct: 1793 SS-----QSTSRRRQRSRSRSRVTRRRRGGSGYHSRSP 1825
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 61.6 bits (148), Expect = 9e-09
Identities = 142/706 (20%), Positives = 258/706 (36%), Gaps = 103/706 (14%)
Query: 767 ALHKSRSTYDQRREQDPPL-------LDSLLRR-KLAKKASRTESRESVEGPPALGFRSA 818
+L + RS + R + D LD+ LR K A E ++ + AL A
Sbjct: 341 SLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIA 400
Query: 819 SAHNLTVGER-------LPRARPASLQK--------------SLSVASSREKALLMASQA 857
+ L GE +P + P L K + V EK ++ +
Sbjct: 401 AYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQ 460
Query: 858 YLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSPAKSSSVDSSHTS 917
E + EE K+AK + E G PA+ ++
Sbjct: 461 TEETQVTEEVTEEEEKEAKEEEG---KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAK 517
Query: 918 GRLHEEARRRLP-HPPIRHQVSTPILALSGGLGEPRMLSPTSTLAPALLPALAP----TP 972
+ EEA+ P + + +P + SP +PA A +P +P
Sbjct: 518 SPVKEEAKSPAEAKSPEKEEAKSPA----------EVKSPEKAKSPAKEEAKSPPEAKSP 567
Query: 973 APALAPVPVSPQSPNLLTYICPWENAELPAKQE-------NVPQEGPSGPERGHHSPAPA 1025
A P +SP E A+ PAK+E P++ S + SPA A
Sbjct: 568 EKEEAKSPAEVKSP---------EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA 618
Query: 1026 RARLWR-ALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGSM 1084
++ + A S A KS E+A +A +++ K K+ K+PV+ +
Sbjct: 619 KSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKA---KSPVKAEAK 675
Query: 1085 RSLGLAIKALTRSRSTYREKESVEE---SPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQ 1141
++S + K V+E SPE S E+ +P ++ + +A + +
Sbjct: 676 SPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK-SPEKAKSPVKEEAKTPE 734
Query: 1142 AALIP-SDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAE------R 1194
A P ++ +S + ++ ++ L V E ++ R E+ +
Sbjct: 735 KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK 794
Query: 1195 AGKTGLAMLRQVSR--DKNIKQSKE--TPVGWQELPKAGL--QSLGSADHRVAEVCPWEV 1248
+ + + L++ ++ +K I + +E +PV +E P+ + A+ A P
Sbjct: 795 SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE 854
Query: 1249 TESETRQPDSGNKAEICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRK 1308
+ ++++ ++ K P + P ++ +++K+ E + K VP K
Sbjct: 855 EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKK------VPTPEK 908
Query: 1309 KPERLVREQEAVCPWESADRGGLSPGSAP-QDPGRIRDKSEAGDSVEARKVEK------- 1360
+ V +E P E + P A ++P + +K EA + K EK
Sbjct: 909 EAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEK 968
Query: 1361 PGWEAAGPE-----AHTPDITKAEPCPWEASEGGEDGKPAQEAVKD 1401
P EA E + P KAE +S +D KP ++A +D
Sbjct: 969 PKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
Score = 52.4 bits (124), Expect = 5e-06
Identities = 135/619 (21%), Positives = 234/619 (37%), Gaps = 105/619 (16%)
Query: 1497 TGRESLQEKEKASRKGSFGEM-----GEQTVK---AVQKLSQQQESVCP--RESTVPGHS 1546
T E + KE+ ++ GE GE+ K A + S ++E+ P E+ P +
Sbjct: 471 TEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEA 530
Query: 1547 -SPCLDNSSSKAGSQFLCNGGSRATQVC--PQEDLRPEAQEATPAKTEICPWEVNERTRE 1603
SP + + S A + S A + P E PE +EA P + +E
Sbjct: 531 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE 590
Query: 1604 EWTSAQVPRGGESQKDKEKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQP 1663
E A+ P +S +K K P K E + + P K+EA P E P + P
Sbjct: 591 E---AKSPAEAKS-PEKAKSPVKEEAKSPAEAKSP----VKEEAKSPAEVKSPEK-AKSP 641
Query: 1664 RPQDTERPQTLLQMSGSVGSKAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEA 1723
++ + P+ KA + EE + KA+ P + A + E+ +A
Sbjct: 642 TKEEAKSPE-----------KAKS---PEKEEAKSPEKAK-SPVKAEAKSPEKAKSPVKA 686
Query: 1724 IRKSPNDTGKVSADLGPRERAVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADG 1783
KSP P + +PEK + P E +A
Sbjct: 687 EAKSPEKA------KSPVKEEAKSPEKAKSPVKE----------------------EAKS 718
Query: 1784 PKAGFQELDHMGCRPGEVCPWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQR 1843
P+ + P + +EA + EKAK K LD K S E +
Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAK-------SPEKAKTLDVK----SPEAK 767
Query: 1844 EKALEKGRLTSLGEDVSKGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVA 1903
A E+ R + D AK ++E + K + A+AP+ E+
Sbjct: 768 TPAKEEARSPA---DKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPE---------KEIP 815
Query: 1904 EGHSLEATEKGDLR-QDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWET 1962
+ +++ K + + Q+ K P+ +EKAPA E + ++ + + ++ P
Sbjct: 816 KKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVE 875
Query: 1963 TAPADSVSHLDRQRPDQPKASSQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWE 2022
+V ++P + K +++ + + + P K D+ K +T E
Sbjct: 876 EKKEPAV-----EKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKT---E 927
Query: 2023 VTERIPVKGVSRQDGKGDSQEEKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDG 2082
V ++ P +++ K E+K APEK + K KKPE + +A +D
Sbjct: 928 VAKKEPDDAKAKEPSK--PAEKKEAAPEKKDTKEEKA-KKPEEKPKTEAKA-----KEDD 979
Query: 2083 KGLSPQPAPDASDRSRGSS 2101
K LS +P+ ++++ SS
Sbjct: 980 KTLSKEPSKPKAEKAEKSS 998
Score = 48.1 bits (113), Expect = 1e-04
Identities = 81/382 (21%), Positives = 152/382 (39%), Gaps = 39/382 (10%)
Query: 1806 AQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGRLTSLGEDVSKGMAK 1865
A+EAA+ EK P + + + + + K+ EK + + E S AK
Sbjct: 506 AEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAK 565
Query: 1866 LCQQQETICIWENK--DLRESPAQ----APKISDLPSSMSSEVAEGHSLEATEKGDLRQD 1919
+++E E K + +SPA+ +P + P S V E A K ++++
Sbjct: 566 SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEE 625
Query: 1920 PKTGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQRPDQ 1979
K+ + E + EKA + EE + + K+ + ++ P + +P + + + P++
Sbjct: 626 AKSPA--EVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKA----EAKSPEK 679
Query: 1980 PKASSQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQDGKG 2039
K+ + + +A P KS AK+ PVK ++ K
Sbjct: 680 AKSPVKAEAKSPEKAKS------PVKEEAKSPEKAKS-----------PVKEEAKSPEKA 722
Query: 2040 DSQ-EEKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSR 2098
S +E+ + PEK++ K PE A ++ +S + K + + A +D+
Sbjct: 723 KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP 782
Query: 2099 GSSEAAGSVETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQ 2158
+++ E + E + E A + EI E +E E+ +E +
Sbjct: 783 EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVK-------V 835
Query: 2159 KAGPGGTEEHFSKAAAKPREQE 2180
K P EE KA A P+ +E
Sbjct: 836 KEPPKKAEE--EKAPATPKTEE 855
Score = 35.0 bits (79), Expect = 0.88
Identities = 61/252 (24%), Positives = 96/252 (38%), Gaps = 26/252 (10%)
Query: 2108 ETRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKAGPGGTEE 2167
ET+V E E E AK+ E G EEG +E E++G E K+ P
Sbjct: 463 ETQVTEEVTEE--EEKEAKEEE--------GKEEEGGEEEEAEGGEEE--TKSPPAEEAA 510
Query: 2168 HFSKAAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAELCQWEIT 2227
K A P ++EA P E + A P SP++A S A+ E
Sbjct: 511 SPEKEAKSPVKEEAKSPAEAKSP----EKEEAKSPAEVKSPEKAKSPAKEEAK-SPPEAK 565
Query: 2228 DPEGNKIKGTMADICPGEETGVPSEESGLLALTATRREFFPTAPEKPLCLLVHGPLDHFF 2287
PE + K + A++ E+ P++E A P + P+ P +
Sbjct: 566 SPEKEEAK-SPAEVKSPEKAKSPAKEEAKSPAEAKS----PEKAKSPVKEEAKSPAEAKS 620
Query: 2288 P---ESKIPCP-KVSRPASTFTLEGVRELQGPSGLEPRTSLAPEPSLQEAESQSSSLTED 2343
P E+K P K A + T E + + E + +PE + ++++ S +
Sbjct: 621 PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKA 680
Query: 2344 SGQVAFEAQYEE 2355
V EA+ E
Sbjct: 681 KSPVKAEAKSPE 692
>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
Length = 941
Score = 60.1 bits (144), Expect = 3e-08
Identities = 58/251 (23%), Positives = 106/251 (42%), Gaps = 24/251 (9%)
Query: 406 RRNKRIWASGVVLLETVLFGFLLLYFPVFIL-----YFKPSVFR--CIALRWVRLLGFAI 458
R K I S + ++ G +L Y +F+ + F C W+ +G+
Sbjct: 507 RNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTT 566
Query: 459 VYGTIILKLYRVLQLFLSRTAQRSALLSSGRLLRRLGLLLLPVLGFLAVW-TVGALERGI 517
+G + K +RV +F + ++ +LL +G +LL L L W V L R +
Sbjct: 567 AFGAMFAKTWRVHAIF-KNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTV 625
Query: 518 QHAPLVIRGHTPSGR---------HFYLCHHDRWDYIMVVAELLLLCWGSFLCYATRAV- 567
+ + P+GR H H W I+ + LL+ +G FL + TR V
Sbjct: 626 EKYSM---EPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVS 682
Query: 568 LSAFHEPRYMGIALHNELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIF 627
+ A ++ +Y+G++++N ++ F+ + + ++ ST+ TL L+F
Sbjct: 683 IPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTI--TLCLVF 740
Query: 628 IPKFWKLGAPP 638
+PK L P
Sbjct: 741 VPKLITLRTNP 751
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 60.1 bits (144), Expect = 3e-08
Identities = 254/1255 (20%), Positives = 406/1255 (32%), Gaps = 262/1255 (20%)
Query: 1097 SRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQ 1156
+ +T +E+ +EE+ EG T GE + + + + ++ + + KE+
Sbjct: 1293 AENTVQEEVQLEETKEG----TEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEG 1348
Query: 1157 QNAHTSRMLQVCQREGSREQED---------------RGRRMTQGLGERKAERAGKTGLA 1201
Q +++ ++ + G QE+ +G + +GL E G
Sbjct: 1349 QQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQ 1408
Query: 1202 MLRQVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNK 1261
L + S ++ PV +E +A AE CP E TE T P
Sbjct: 1409 ELSEASSPDGKGSQEDDPVQEEEAGRASAS---------AEPCPAEGTEEPTEPP----- 1454
Query: 1262 AEICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAVC 1321
S DP S+++ G + P + K P + QE
Sbjct: 1455 --------------SHLSETDPSASERQSGS--------QLEPGLEKPPGATMMGQEHT- 1491
Query: 1322 PWESADRGGLSPGSAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEPC 1381
++ G + S+ D SV +K EK AH
Sbjct: 1492 --QAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFL------AHLASAVAELRA 1543
Query: 1382 PWEASEGGEDGKPAQEAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFRGPSAV 1441
W + + A E +D+ Q Q + K K Q G + P E+ G +
Sbjct: 1544 RWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREA--LTGELLL 1601
Query: 1442 SIQAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTGRES 1501
Q Q+ + + + L LG +
Sbjct: 1602 QTQ-----------------------------QRRHRLRGLRNLSAFSERTLGLGPLSFT 1632
Query: 1502 LQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPCLDNSSSKAGSQF 1561
L++ E A ++GE+ + E CP E+ V SP + ++ ++
Sbjct: 1633 LED-EPALSTALGSQLGEEA---------EGEEFCPCEACVRKKVSP-MSPKATMGATRG 1681
Query: 1562 LCNGGSRATQVCPQ---EDLRPEAQEATPAKTEICPWEVNERTREEWTSAQVPRGGESQK 1618
Q+ + E EA E P KT P TS + +G E
Sbjct: 1682 PIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDP-----------TSTRTVQGAEGGL 1730
Query: 1619 DKEKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMS 1678
PG S+ V E EG + P G Q R T +T
Sbjct: 1731 G----PGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSET----- 1781
Query: 1679 GSVGSKAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPNDTGKVSADL 1738
S GS+ + + E + + E G G+G E L EA D G+
Sbjct: 1782 -SAGSELGEA---EQEGEGISERGETG----GQGSGHEDNLQGEAAAGGDQDPGQSDGAE 1833
Query: 1739 GPRERAVTAPEKPQKPTPEWE-VACPW--GSVGPGACSQHPGTLDADGPKAGFQELDHMG 1795
G + APE + PE E V P G P + D + P+A +
Sbjct: 1834 G-----IEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESE 1888
Query: 1796 CRPGEVCPWEAQ------EAATSEKAKICPWEVSEGTTGKGLDQ--KAGSESAEQREKAL 1847
WE Q EA +EK E E +G D+ G+E+ E E A
Sbjct: 1889 DVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQ 1948
Query: 1848 EKGRLTSLGEDVSKGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVAEGHS 1907
E T Q E+ I + E+ ++ + L + ++ AEG +
Sbjct: 1949 EAEGQT---------------QPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
Query: 1908 ------LEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWE 1961
+EA E Q+ + + PE E P ++ EE +GE E
Sbjct: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTE-------- 2045
Query: 1962 TTAPADSVSHLDRQRPDQPKASSQRLVSTGGRAADVCPWDVPDAGVYKSDSSAKAET--- 2018
D+ D + + +Q A + D +++ A+ E+
Sbjct: 2046 ----GDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGV 2101
Query: 2019 -CPWEVTERIPVKGVSRQDGKGDSQEEKG--RAPE-----KSEPKGVPVQK-----KPEM 2065
P E +G+ + +G++Q E APE + E +GV Q +PE
Sbjct: 2102 EAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPES 2161
Query: 2066 ADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGSSEAAGSVETRVAEVCLWEVVEAPSA 2125
QEA E + L AP+A ++ SE + E E VEAP A
Sbjct: 2162 EGIEAQEA----EEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEA 2217
Query: 2126 KKAEICPWEAGGGAAE-EGEQERESQG--QGEMFLQ---KAGPGGTEEHFSKAAAKPREQ 2179
++ E P G E EGE + ES+G QGE G G +EE ++ P ++
Sbjct: 2218 EE-EAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDR 2276
Query: 2180 EAVCPGEG----------------------------------------------TGSGGL 2193
P G TG+
Sbjct: 2277 PTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHA 2336
Query: 2194 LPQSGALDPELKVSPKEAGSMGSRMAELCQWEITDPEGNKIKGTMADICPGEETG 2248
++ + PE S +E +GSR E E D + ++ G++A P E G
Sbjct: 2337 ERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQALGSLA---PTEAVG 2388
Score = 51.2 bits (121), Expect = 1e-05
Identities = 336/1630 (20%), Positives = 568/1630 (34%), Gaps = 281/1630 (17%)
Query: 796 KKASRTESRESVEG----PPALGFRSASAHNLTVGERLPRARPASLQKSLSVASSREKAL 851
K + T +E+ EG PAL S + +L + +++ A +RE +
Sbjct: 558 KARAETSQQEASEGGDPASPALSLSSLRSDDLQA-----ETQGQGTEQATGAAVTREPLV 612
Query: 852 LMASQAYLEE-------TYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPS 904
L S ++ E T +++ + R +++A+ S P R+ PRG P +
Sbjct: 613 LGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVA-PRGHPRHSHYR 671
Query: 905 PAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTP--ILALSGGLGEPR------MLSP 956
S +DSS T +++P PP R + + SG R + P
Sbjct: 672 KDTHSPLDSSVT---------KQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPP 722
Query: 957 TSTLAPA--LLPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSG 1014
+S P+ LL + T PA+ VS SP+ N P G +G
Sbjct: 723 SSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPH------------------NAPSAGWAG 764
Query: 1015 PERGHH-SPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDEDRPK---IFP 1070
SPAP S + KS A +A D + RP+ + P
Sbjct: 765 DAGSRTCSPAPIPPHT----SDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGP 820
Query: 1071 -KSHSLKAPVQQGSMRSL-GLAIKALTRSRSTYREKESVEESPEGQNS--GTAGESMGAP 1126
+SH P Q + + G + +A P+ ++S G+ G S +
Sbjct: 821 HRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQST 880
Query: 1127 SRSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQG 1186
+R P G P+ ++Q PS N+ SR Q GSR G
Sbjct: 881 ARGPG-GSPQEGTRQPGPTPSPGP-------NSGASRRSSASQGAGSR-----------G 921
Query: 1187 LGERKAERA--GKTGLAMLRQVSRDKNIKQSKETPVG-WQE-LPKAGLQSLGSADHRVAE 1242
L E K R+ G G VS + S E V W + +P+ +
Sbjct: 922 LSEEKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPI------------ 969
Query: 1243 VCPWEVTESETRQPDSGNKA-EICPWE--TSEGAPE-----SRALRQDPGDSQKKRGEAR 1294
+ +E+ + T G + E+ P + + EG E ++L DPG + G
Sbjct: 970 LMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALL 1029
Query: 1295 GKSEPIDVVPMMRKK-PERLVREQEAVCPWESADRGGLSPG---SAPQDPGRIRDKSEAG 1350
G S D P + P+ E + P E+ G S PGR+ S +
Sbjct: 1030 GSS---DTGPQSGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGRV---SAST 1083
Query: 1351 DSVEARKVEKPGWEAAGPEAHTPDITKAE-------PCPWEASEGGED-GKPAQEA-VKD 1401
+ A K G ++ PE P + C ED G PA + KD
Sbjct: 1084 QIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKD 1143
Query: 1402 LPQEKQKTR-KATFWKEQKPGGDLESLCPWEST------DFRGPSAVSIQAPGSSE---- 1450
P+ ++ W G D WE T D + P SS
Sbjct: 1144 SPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGVDI 1203
Query: 1451 CSGSLGSGIAEV-------CLWEAGDAP---AIQKAEICPWELDDNVMGQEMLSLGT--- 1497
SGS GSG + V + + + P + Q+ + +E ++ Q+ T
Sbjct: 1204 SSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLN 1263
Query: 1498 ---------GRESLQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSP 1548
E+ ++ E+ + ++ E TV+ +L + +E E +
Sbjct: 1264 ARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGT---EGEGLQEEAV 1320
Query: 1549 CLDNSSSKAGSQFLCNGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSA 1608
L+ + ++ G Q Q+ ++ E Q+ A+ E E +EE
Sbjct: 1321 QLEETKTEEGLQ------EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQL 1374
Query: 1609 QV----PRGG------ESQKDKEKMPGKSEI--EDVTAWEKPEGQIQKQEAVGPWESVDP 1656
+ P GG E +E +P + + ++++ P+G+ +++ E
Sbjct: 1375 EEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGR 1434
Query: 1657 GSFSPQPRPQD-----TERPQTLLQM--SGSVGSKAADICP-LDVEENLTAGKAEICPWE 1708
S S +P P + TE P L + S S + + P L+ T E +
Sbjct: 1435 ASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQ 1494
Query: 1709 VGAGAGEERALGAEAIRKSPNDTGKVSADLGPRERAVTAPEKPQKPTPEWEVACPWGSVG 1768
GA E R+ D VS L E+A A + E+ WG
Sbjct: 1495 PTQGAAE-RSSSVACSAALDCDPIWVSVLLKKTEKAFLA----HLASAVAELRARWGLQD 1549
Query: 1769 PGACSQHPGTLDADGPK----AGFQELDHMGCRPGEVCPWEAQEAATSEKAKICPWE--- 1821
Q L D + + +EL + R G + +EA T E
Sbjct: 1550 NDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHR 1609
Query: 1822 ---------VSEGTTGKG-----------LDQKAGSESAEQRE-------KALEKGRLTS 1854
SE T G G L GS+ E+ E +A + +++
Sbjct: 1610 LRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSP 1669
Query: 1855 LGEDVSKGMAK--LCQQQETICIWENKDLRESPAQAPKIS------DLPSSMSSEVAEGH 1906
+ + G + + + + I + K + +A +++ D S+ + + AEG
Sbjct: 1670 MSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGG 1729
Query: 1907 SLEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWETTAPA 1966
+G + + G + + ++K P E G+ + E + T+
Sbjct: 1730 LGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAE-----GDAMAQEREGKTHNSETSAG 1784
Query: 1967 DSVSHLDRQRPDQPKASSQRLVSTGGRAA--------DVCPWDVPDAGVYKSDSSAKAET 2018
+ +++ + S+R TGG+ + + D G +SD + E
Sbjct: 1785 SELGEAEQEG----EGISER-GETGGQGSGHEDNLQGEAAAGGDQDPG--QSDGAEGIEA 1837
Query: 2019 CPWEVTERIPVKGVSRQDGKGDSQEEKGRAPEKSEPKGVPV---QKKPEMADFRQQEAVC 2075
E + +GV + +GD+QE +G A +SE P + +PE D EA
Sbjct: 1838 PEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEA-- 1895
Query: 2076 PWESQ-DGKGLSPQPAPDASDRSRGSSEAAGSVETRVAEVCLWEVVEAPSAKKAEICPWE 2134
WE Q + +G AP+A ++ +E+ ++ET + E A++AE E
Sbjct: 1896 EWEVQPESEGAE---APEAEKEAQPETESVEALETEGEDE---PESEGAEAQEAEEAAQE 1949
Query: 2135 AGGGAAEEGE----QERESQGQGEMFLQKAGPGGTEEHFSKAAAKPREQEAVCPGEGTGS 2190
A G E E QE E + Q E +A E ++ A+P ++ P
Sbjct: 1950 AEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAP---EAE 2006
Query: 2191 GGLLPQSGALDPE---LKVSPKEAGSMGSRMAELCQWEITD--PEGNKIKGTMADICPGE 2245
G + PE ++ PK G + Q D PE + ++ A+ E
Sbjct: 2007 GEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQE 2066
Query: 2246 ETGVPSEESG 2255
G E G
Sbjct: 2067 AEGEVQEAEG 2076
Score = 43.9 bits (102), Expect = 0.002
Identities = 102/478 (21%), Positives = 176/478 (36%), Gaps = 56/478 (11%)
Query: 1043 GENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYR 1102
GE + ++E D E + P+S ++AP +G +
Sbjct: 1842 GEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQP---------------- 1885
Query: 1103 EKESVEESPEGQNSGTAGESMGAPS-RSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHT 1161
E E V E+PE + ES GA + + + +P+ S +A +D+ + +
Sbjct: 1886 ESEDV-ETPEAEWE-VQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEA 1943
Query: 1162 SRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAMLRQVSRDKNIKQSK----E 1217
Q + EG + E + E + E L + + + Q + E
Sbjct: 1944 EEAAQ--EAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVE 2001
Query: 1218 TPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAPESR 1277
P E+ +A ++ +D A+ E + + P APE+
Sbjct: 2002 APEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE 2061
Query: 1278 ALRQD-PGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPG-S 1335
Q+ G+ Q+ GEA +SE +D ++ E E V E+ + G
Sbjct: 2062 EEAQEAEGEVQEAEGEAHPESEDVDA----QEAEGEAQPESEGVEAPEAEGEAQKAEGIE 2117
Query: 1336 APQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAEPCPWEASEGGEDGKPA 1395
AP+ G + +SE ++ EA +P E+ G EA + +A+P SEG E A
Sbjct: 2118 APETEGEAQPESEGIEAPEAEGEAQP--ESEGVEAQDAE-GEAQP----ESEGIE----A 2166
Query: 1396 QEAVKDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFRGPSAVSIQAPGSSECSGSL 1455
QEA ++ E + E +P + E + E+ P ++AP + E +
Sbjct: 2167 QEAEEEAQPELEGVEAPEAEGEAQP--ESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224
Query: 1456 GSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTGRESLQEKEKASRKGS 1513
G+ E +A + E E G +SLG G + E+AS S
Sbjct: 2225 PEGV------ETPEAEGEAQPE-SEGETQGEKKGSPQVSLGDG-----QSEEASESSS 2270
Score = 43.1 bits (100), Expect = 0.003
Identities = 228/1062 (21%), Positives = 346/1062 (32%), Gaps = 223/1062 (20%)
Query: 1261 KAEICPWETSEGA-PESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQEA 1319
+AE E SEG P S AL S + E +G+ + ++P L
Sbjct: 560 RAETSQQEASEGGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVTREPLVLGLS--- 616
Query: 1320 VCPWESADRGGLSPGSAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDITKAE 1379
C W+S G+ R +S A PG P H
Sbjct: 617 -CSWDSEGASSTPSTCTSSQQGQRRHRSRAS---AMSSPSSPGLGRVAPRGH-------- 664
Query: 1380 PCPWEASEGGEDGKPAQEAV-KDLPQEKQKTRKATFWKEQKPGGDLESLCPWESTDFRGP 1438
P + + P +V K +P+ ++ R + G S S + R P
Sbjct: 665 --PRHSHYRKDTHSPLDSSVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPP 722
Query: 1439 SAVSIQAPGSSECSGSLGSGIAEVCLWEAGDAPAIQKAEICPWELDDNVMGQEMLSLGTG 1498
S+ S+ S + G+ + + + + A W D G S
Sbjct: 723 SSGSLP---SQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGD---AGSRTCSPAPI 776
Query: 1499 RESLQEKEKASRKGSFGEMGEQTVKAVQKLSQQQESVCPRESTVPGHSSPCLDNSSSKAG 1558
+ S S GE T + L Q P + V H S C S+ G
Sbjct: 777 PPHTSDSCSKSGAASLGEEARDTPQPSSPLVLQVGR--PEQGAVGPHRSHCC----SQPG 830
Query: 1559 SQFLCNGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTREEWTSAQVPRGGESQK 1618
+Q QE R + EA+ CP PRG +
Sbjct: 831 TQ------------PAQEAQRGPSPEASWLCGRYCPTP--------------PRGRPCPQ 864
Query: 1619 DKEKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQDTERPQTLLQMS 1678
+ G + G + A GP S G+ P P P + S
Sbjct: 865 RRSSSCGST------------GSSHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSS 912
Query: 1679 GSVGSKAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPNDTGKVSADL 1738
S G+ + L E+ L +G G G+E A G SP+ + S +
Sbjct: 913 ASQGAGSRG---LSEEKTLRSG---------GGPQGQEEASGV-----SPSSLPRSSPEA 955
Query: 1739 GPRERAVTAPEKPQKPT----PEWEVACPWGSVGPGACSQHPGTLDADGP--KAGFQELD 1792
RE PE+P T E A G GP +L+ G +AG Q L+
Sbjct: 956 VVREWLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLE 1015
Query: 1793 HMGCRPGEVCPWEAQEAATSEKAK---------ICPWEVSEGTTGKGLDQKAGS------ 1837
PG+ E +S+ P VSE G D++A +
Sbjct: 1016 G---DPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSL 1072
Query: 1838 -------ESAEQREKAL---EKGRLTSLGEDVSKGMAKL--CQQQETICIWENKDLRE-- 1883
++ Q +AL ++GR +S+ E VS+ MA+ C I + L E
Sbjct: 1073 RALPGRVSASTQIMRALMGSKQGRPSSVPE-VSRPMARRLSCSAGALITCLASLQLFEED 1131
Query: 1884 --SPAQAPKISDLPS-----SMSSEVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPA 1936
SPA + D P S+S ++ G D+ +D E + P
Sbjct: 1132 LGSPASKVRFKDSPRYQELLSISKDLWPGC--------DVGEDQLDSGLWELTWSQALPD 1183
Query: 1937 ----ADTEEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQRPDQP-KASSQRLVSTG 1991
A TE FT S E++ P L Q + P K S+QR
Sbjct: 1184 LGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQR----- 1238
Query: 1992 GRAADVCPWDVPDAGVYKS--DSSAKAETC-PWEVTERIPVKGVSRQDGKGDSQEEKGRA 2048
PD+ Y+S D + + C P + R + + + DS+E++ +
Sbjct: 1239 -----------PDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASS 1287
Query: 2049 PEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGSSEAAGSVE 2108
+ + VQ++ ++ + + E +G+GL EA E
Sbjct: 1288 NLEQLAENT-VQEEVQLEETK--------EGTEGEGLQ--------------EEAVQLEE 1324
Query: 2109 TRVAEVCLWEVVEAPSAKKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKAGPGGTEEH 2168
T+ E E V+ K+ E GE ++E + Q E + G G EE
Sbjct: 1325 TKTEEGLQEEGVQLEETKETE-------------GEGQQEEEAQLEEIEETGGEGLQEEG 1371
Query: 2169 FSKAAAKPREQEAVCPGEGTGSGGLLPQSGALDPELKVS--PKEAGSMGSRMAELCQ--- 2223
K EG GGL Q AL+ LK P+E G ++E
Sbjct: 1372 VQLEEVK----------EGP-EGGL--QGEALEEGLKEEGLPEEGSVHGQELSEASSPDG 1418
Query: 2224 --WEITDPEGNKIKG---TMADICPGEETGVPSEESGLLALT 2260
+ DP + G A+ CP E T P+E L+ T
Sbjct: 1419 KGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSET 1460
Score = 40.8 bits (94), Expect = 0.016
Identities = 110/491 (22%), Positives = 179/491 (36%), Gaps = 108/491 (21%)
Query: 983 PQSPNLLTYICPWE------NAELP-AKQENVPQ---------EGPSGPERGHHSPAPAR 1026
P+S ++ T WE AE P A++E P+ EG PE A
Sbjct: 1885 PESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAE 1944
Query: 1027 ARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVD---------EDRPKIFPKSHSLKA 1077
A +S E++ E+A Q E+ DV+ E + P+S ++A
Sbjct: 1945 EAAQEAEGQTQPESEVIESQEAEEEA--QPESEDVEALEVEVETQEAEGEAQPESEDVEA 2002
Query: 1078 PVQQGSMRSLGLAIKALTRSRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKA 1137
P +G M+ E + VE P+ + A E G ++ +P+
Sbjct: 2003 PEAEGEMQE---------AEEEAQPESDGVEAQPKSEGE-EAQEVEGETQKTEGDAQPE- 2051
Query: 1138 VSKQAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGK 1197
SD E+ + ++ A + +V + EG E + GE + E G
Sbjct: 2052 ---------SDGVEAPEAEEEAQEAEG-EVQEAEGEAHPESEDVDAQEAEGEAQPESEG- 2100
Query: 1198 TGLAMLRQVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPD 1257
E P+A + + AE TE E +
Sbjct: 2101 -------------------------VEAPEA------EGEAQKAEGIEAPETEGEAQPES 2129
Query: 1258 SGNKAEICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKPERLVREQ 1317
G +A P E PES + ++Q GEA+ +SE I+ ++ E E
Sbjct: 2130 EGIEA---PEAEGEAQPESEGV-----EAQDAEGEAQPESEGIEA----QEAEEEAQPEL 2177
Query: 1318 EAV-CPWESADRGGLSPG-SAPQDPGRIRDKSEAGDSVEARKVEKPGWEAAGPEAHTPDI 1375
E V P + S G AP+ G + + E ++ EA + +P E G E TP+
Sbjct: 2178 EGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQP--EPEGVE--TPEA 2233
Query: 1376 T-KAEPCPWEASEGGEDGKPAQEAVKDLPQEKQKTRKATFWKEQ-----KPGGDLESLCP 1429
+A+P ++G + G P Q ++ D E+ + +++ PGGD P
Sbjct: 2234 EGEAQPESEGETQGEKKGSP-QVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRP 2292
Query: 1430 WESTDFRGPSA 1440
T GPS+
Sbjct: 2293 GSQT---GPSS 2300
Score = 39.7 bits (91), Expect = 0.036
Identities = 58/252 (23%), Positives = 97/252 (38%), Gaps = 33/252 (13%)
Query: 996 ENAELPAKQ-ENVPQ-EGPSGPE-RGHHSPAPARARLWRALSVAVEKSRAGENEMDAEDA 1052
E E P + E P+ EG PE G P A A +S E + E+A
Sbjct: 2114 EGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEA 2173
Query: 1053 HHQREANDVDEDRPKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYREKESVEESPE 1112
+ E + E + P+S ++AP +G + ++A E E VE +PE
Sbjct: 2174 QPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVE-TPE 2232
Query: 1113 GQNSG-------TAGESMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHTSRML 1165
+ T GE G+P S G+ + S+ ++ +P +D+ + T
Sbjct: 2233 AEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVP-EDRPTPPPSPGGDTPH-- 2289
Query: 1166 QVCQREGSREQEDRGRRMTQG------------LGERKAERAGKTGLAML-RQVSR---D 1209
QR GS+ R + G LG+ ++ A TG R+ +R +
Sbjct: 2290 ---QRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPE 2346
Query: 1210 KNIKQSKETPVG 1221
+ + +E P+G
Sbjct: 2347 SSTSEQEEAPLG 2358
>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
precursor [Homo sapiens]
Length = 1194
Score = 58.9 bits (141), Expect = 6e-08
Identities = 104/488 (21%), Positives = 174/488 (35%), Gaps = 71/488 (14%)
Query: 356 CLPCPEGCTSCMDATPC------LVEEAAVLRAAVLACQACCMLAIFLSMLVSYRCRRNK 409
C C G D T C +E + + +A +L L+ R
Sbjct: 562 CKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTP 621
Query: 410 RIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKLYR 469
+ +S L +L G L Y F L KP+ C R + L A+ Y ++ K R
Sbjct: 622 VVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNR 681
Query: 470 VLQLFLS---RTAQRSALLSSGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLVIRG 526
+ ++ + R S + +L+ V L V + I P+ I
Sbjct: 682 IARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLI------IMEPPMPILS 735
Query: 527 HTPSGRHFYLCHHDRWDYIMVVAEL----LLLCWGSFLCYATRAVLSAFHEPRYMGIALH 582
+ + +C+ + VVA L LL+ ++ + TR V + F+E +Y+ ++
Sbjct: 736 YPSIKEVYLICNTSN---LGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMY 792
Query: 583 NELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIFIPKFWKLGAPPREEM 642
++ AF F ++ ++ F +VT L +F PK + + A P +
Sbjct: 793 TTCIIWLAFVPIYF------GSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNV 846
Query: 643 VDEVCEDELDLQH-----------------------SGSYLGSSIASAWSEHSLDPGDIR 679
++ H +G+ + + +WSE G
Sbjct: 847 RSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPG---GGQV 903
Query: 680 DELKKLYAQLEVH-KTKEMAANNPHLPKKRGSSCQGLGRSF--------MRYLAEFPEAL 730
+ + ++ +L VH KT E A N + K S QG G+S Y E E
Sbjct: 904 PKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDA 963
Query: 731 ARQHSRDSGSPG---HGSLPGSSRRRLLSSSLQEPE-----GTPALHKSRSTYDQRREQD 782
GSP H +P ++ L S L E PAL K Q+++Q
Sbjct: 964 QPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQP 1023
Query: 783 PPLLDSLL 790
PP SL+
Sbjct: 1024 PPQQKSLM 1031
>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
sapiens]
Length = 879
Score = 53.5 bits (127), Expect = 2e-06
Identities = 66/302 (21%), Positives = 119/302 (39%), Gaps = 26/302 (8%)
Query: 356 CLPCPEGCTSCMDATPCLV--------EEAAVLRAAVLACQACCMLAIFLSMLVSYRCRR 407
C+ C G D T C E+A + +AC + +++ + +
Sbjct: 546 CMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHN--N 603
Query: 408 NKRIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKL 467
+ ASG L +LFG L Y F KPS C R FAI Y ++ K
Sbjct: 604 TPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKT 663
Query: 468 YRVLQLF--LSRTAQRSALLS-SGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLVI 524
+ ++F + AQR +S S ++ LGL+L+ ++ ++VW I AP
Sbjct: 664 NCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIV-MVSVWL-------ILEAPGTR 715
Query: 525 RGHTPSGRHFYLCHHDRWDYIMVVA---ELLLLCWGSFLCYATRAVLSAFHEPRYMGIAL 581
R R + + D M+++ +++L+ + + TR F+E +++G +
Sbjct: 716 RYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTM 775
Query: 582 HNELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIFIPKFWKLGAPPREE 641
+ ++ AF +V T + V L +F PK + P++
Sbjct: 776 YTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFV--VLGCLFAPKVHIILFQPQKN 833
Query: 642 MV 643
+V
Sbjct: 834 VV 835
>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
[Homo sapiens]
Length = 1212
Score = 51.6 bits (122), Expect = 9e-06
Identities = 72/323 (22%), Positives = 118/323 (36%), Gaps = 26/323 (8%)
Query: 356 CLPCPEGCTSCMDATPCLVEEAAVLR--------AAVLACQACCMLAIFLSMLVSYRCRR 407
C C G D T C + LR A V AC +LA +V R
Sbjct: 549 CKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLG--LLATLFVTVVFIIYRD 606
Query: 408 NKRIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKL 467
+ +S L +L G L Y F L KP C R L A+ Y ++ K
Sbjct: 607 TPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKT 666
Query: 468 YRVLQLFLSRTAQRSALLSSGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLVIRGH 527
R+ ++ +++ R + L++ + L +G + P I
Sbjct: 667 NRIARILAG--SKKKICTKKPRFMSACAQLVIAFI--LICIQLGIIVALFIMEPPDIMHD 722
Query: 528 TPSGRHFYL-CHHDRWDYIMVVAE---LLLLCWGSFLCYATRAVLSAFHEPRYMGIALHN 583
PS R YL C+ + + L+L C +F + TR V + F+E +Y+ ++
Sbjct: 723 YPSIREVYLICNTTNLGVVTPLGYNGLLILSC--TFYAFKTRNVPANFNEAKYIAFTMYT 780
Query: 584 ELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIFIPKFWKLGAPPREEMV 643
++ AF F ++ ++ F + T L +F+PK + + A P +
Sbjct: 781 TCIIWLAFVPIYF------GSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVR 834
Query: 644 DEVCEDELDLQHSGSYLGSSIAS 666
+ H G SS AS
Sbjct: 835 SAFTTSTVVRMHVGDGKSSSAAS 857
>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
[Homo sapiens]
Length = 1180
Score = 51.6 bits (122), Expect = 9e-06
Identities = 72/323 (22%), Positives = 118/323 (36%), Gaps = 26/323 (8%)
Query: 356 CLPCPEGCTSCMDATPCLVEEAAVLR--------AAVLACQACCMLAIFLSMLVSYRCRR 407
C C G D T C + LR A V AC +LA +V R
Sbjct: 549 CKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLG--LLATLFVTVVFIIYRD 606
Query: 408 NKRIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKL 467
+ +S L +L G L Y F L KP C R L A+ Y ++ K
Sbjct: 607 TPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKT 666
Query: 468 YRVLQLFLSRTAQRSALLSSGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLVIRGH 527
R+ ++ +++ R + L++ + L +G + P I
Sbjct: 667 NRIARILAG--SKKKICTKKPRFMSACAQLVIAFI--LICIQLGIIVALFIMEPPDIMHD 722
Query: 528 TPSGRHFYL-CHHDRWDYIMVVAE---LLLLCWGSFLCYATRAVLSAFHEPRYMGIALHN 583
PS R YL C+ + + L+L C +F + TR V + F+E +Y+ ++
Sbjct: 723 YPSIREVYLICNTTNLGVVTPLGYNGLLILSC--TFYAFKTRNVPANFNEAKYIAFTMYT 780
Query: 584 ELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIFIPKFWKLGAPPREEMV 643
++ AF F ++ ++ F + T L +F+PK + + A P +
Sbjct: 781 TCIIWLAFVPIYF------GSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVR 834
Query: 644 DEVCEDELDLQHSGSYLGSSIAS 666
+ H G SS AS
Sbjct: 835 SAFTTSTVVRMHVGDGKSSSAAS 857
>gi|112821681 G protein-regulated inducer of neurite outgrowth 1 [Homo
sapiens]
Length = 1008
Score = 50.1 bits (118), Expect = 3e-05
Identities = 92/403 (22%), Positives = 139/403 (34%), Gaps = 60/403 (14%)
Query: 1067 KIFPKSHSLKAPVQQG--SMRSLGLA--IKALTRSRSTYREKESVEESPEGQNSGTAGES 1122
K+ P+S PV G RSLG A A+ +T + + + + +G
Sbjct: 478 KVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSS----EKAGLVASG 533
Query: 1123 MGAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGRR 1182
AP+ S + P AV K+ + S K + + +V G G+
Sbjct: 534 KAAPTASGK-AEPLAVGKEDPV--SKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKV 590
Query: 1183 MTQGLGERKAERAGKTGLAMLRQVS------RDKNIKQSKETPVGWQELPKAGLQSLGSA 1236
LG+ +A GK G L + S D + G + K Q +A
Sbjct: 591 DPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAA 650
Query: 1237 DHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAPESRALRQDPGDSQKKRGEARGK 1296
VC + T + + D G+ + P + +G P S + D S+K + GK
Sbjct: 651 PGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLG-KADSAPSRKTESPSLGK 709
Query: 1297 SEPIDVVPMMRKKPERLVREQEAVCPWESADRGGLSPGSAPQDPGRIRDKSEAGDSVEAR 1356
P+ + + KP R+ + A SP A GR+ K+E S EA
Sbjct: 710 VVPLS---LEKTKPSSSSRQLD-----RKALGSARSPEGARGSEGRVEPKAEPVSSTEAS 761
Query: 1357 KVEKPGWEAAGPEAHTPDITKAEPCPWEASEGGEDGKPAQEAVKDLPQEKQKTRKATFWK 1416
+ + EAAG E PCP A A P+ + KA W+
Sbjct: 762 SLGQKDLEAAGAE--------RSPCPEAA------------APPPGPRTRDNFTKAPSWE 801
Query: 1417 EQKPGGDLE--------------SLCPWESTDFRGPSAVSIQA 1445
P E ++ P D G SA S QA
Sbjct: 802 ASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQA 844
Score = 42.7 bits (99), Expect = 0.004
Identities = 210/914 (22%), Positives = 305/914 (33%), Gaps = 120/914 (13%)
Query: 1245 PWEVTESETRQPDSGNKA--EICPWETSEGAPESRALRQDPGDSQKKRGEARGKSEPI-- 1300
P ++E + D N E +++S+ A + ++DPG S+K GK+EP
Sbjct: 131 PVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEIL 190
Query: 1301 ---DVVPMMRKKPERLVREQEA----VCPWESADRGGLSPGSAPQDPGRIRD----KSEA 1349
D V R P + +E V P S+ +SP +DPG +R S+
Sbjct: 191 GKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRK--EDPGSLRKVDPVSSDK 248
Query: 1350 GDSVEARKVEKPGWEAAGPEAHTPDITKAEPCPWEASEGGEDGK--PAQEAVKDLPQEKQ 1407
D V RK E+P + + H K P E + GK P D P +
Sbjct: 249 VDPVFPRK-EEPRYSG---KEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKAD-PMPLE 303
Query: 1408 KTRKATFWKEQKPGGDLESLCPWESTDFRGPSAVSIQAPGSSECSGSLGSGIAEVCLWEA 1467
A+ K + G L L P S GP + APGS LG + CL A
Sbjct: 304 SMDSASTGKTEP--GLLGKLIPGSSGK-NGPVSSGTGAPGS------LGR-LDPTCLGMA 353
Query: 1468 GDAPAIQKAEICPWELDDNVMGQEM--LSLGTGRE----------------SLQEKEKAS 1509
D ++ E P +D+ +M S G GR SL+ + S
Sbjct: 354 -DPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMS 412
Query: 1510 RKG----SFGEMGEQTVKAVQKLSQQQE---SVCPRESTVPGHSSPCLDNSSSKAGSQFL 1562
S G+M + LS Q SV + PG P +
Sbjct: 413 SGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISA--- 469
Query: 1563 CNGGSRATQVCPQEDLRPEAQEATPAKTEIC--PWEVNERTREEWTSAQVPRGGESQKDK 1620
GSR T E + PE+ T + P + A+ GG+
Sbjct: 470 ---GSRKTS---SEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLS 523
Query: 1621 EKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQPRPQ-DTERPQTLLQMSG 1679
+ G + A G+ + AVG + V G P Q D+ ++ G
Sbjct: 524 SEKAGL--VASGKAAPTASGKAEPL-AVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPG 580
Query: 1680 S---VGSKAADICPLDVEENLTAGKAEICPWEVGAGAGEERALGAEAIRKSPNDTGKVSA 1736
V S D L E + GK P E G+ +A + + P GK
Sbjct: 581 KTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAET 640
Query: 1737 DLGPRERAVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPGTLDADGPKAGFQELDHMGC 1796
L P + AP + + E V PG+C + G + D
Sbjct: 641 KL-PGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPS 699
Query: 1797 RPGEVCPWEAQEAATSEKAKICPWEVSEGTTGKGLDQKAGSESAEQREKALEKGRLTSLG 1856
R E + EK K ++ + LD+KA + +GR+
Sbjct: 700 RKTESPSLGKVVPLSLEKTK-------PSSSSRQLDRKALGSARSPEGARGSEGRVEPKA 752
Query: 1857 EDVSKGMAKLCQQQETICIWENKDLRESPAQAPKISDLPSSMSSEVAEGHSLEATEKGDL 1916
E VS A Q++ E SP + S EA+
Sbjct: 753 EPVSSTEASSLGQKDL----EAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPP 808
Query: 1917 RQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQR 1976
R+D T + + + +DG S P + P S D
Sbjct: 809 REDAGT-----QAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPP----SRRDAGL 859
Query: 1977 PDQPKASSQRLVSTGGRAAD-VCPWDVPDAGVYKSDSSAKAETCPWEVTERIPVKGVSRQ 2035
A+ R V+TG P P+ V + S+ A P E E PV+ VS
Sbjct: 860 QVSLGAAETRSVATGPMTPQAAAPPAFPEVRV-RPGSALAAAVAPPEPAE--PVRDVS-W 915
Query: 2036 DGKGDSQEEKGRAPEKSEPKGVPVQKKPEMADFRQQEAVCPWESQDGKGLSPQPAPDASD 2095
D KG + E G A E E G+ +QK E RQ E + G+ +P P P A
Sbjct: 916 DEKGMTWEVYGAAME-VEVLGMAIQKHLE----RQIE-------EHGRQGAPAPPPAA-- 961
Query: 2096 RSRGSSEAAGSVET 2109
R +GSV T
Sbjct: 962 --RAGPGRSGSVRT 973
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 49.3 bits (116), Expect = 4e-05
Identities = 84/334 (25%), Positives = 125/334 (37%), Gaps = 54/334 (16%)
Query: 736 RDSGSPGHGSLPGSSRRRLLSSSLQEPEGTPALHKSRSTYDQRREQDPPL----LDSLLR 791
R SG+ G L R ++ + T A +S + RR+ P ++ R
Sbjct: 110 RASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMAR 169
Query: 792 RK--------LAKKASRTESRESVEGPPALGFRSASAHNLTVGERLPRARPAS---LQK- 839
R L + A R EGP SAS H+ T R RP++ LQ+
Sbjct: 170 RSRAAGTEVGLPRPAPSARPRPPTEGPRK-SVSSASEHSTTEPSPAARRRPSAGGGLQRP 228
Query: 840 -SLSVASSREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSA---RRLERPR 895
S S++SS A +A + K K A +R P R+ P
Sbjct: 229 ASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQA--LRPPQVTPPRKDAAPA 286
Query: 896 GAPLSAPPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRM-- 953
PLS+ P S S S ++ + + LP PP +TP + LG P +
Sbjct: 287 LGPLSSSPLATPSPSAPPSPSA----PPSLQTLPSPP-----ATPPSQATTSLGSPTLQA 337
Query: 954 ---------LSPTSTLAPALLPALA---------PTPAPALAPVPV-SPQSPN-LLTYIC 993
LSP +T P PALA P +P L+P+ SPQ+PN L ++
Sbjct: 338 THSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLL 397
Query: 994 PWENAELPAKQENVPQEGPSGPERGHHSPAPARA 1027
+ P+ P P+ P + P++A
Sbjct: 398 QAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQA 431
Score = 35.0 bits (79), Expect = 0.88
Identities = 39/122 (31%), Positives = 49/122 (40%), Gaps = 18/122 (14%)
Query: 894 PRGAPLSAPPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRM 953
P P+ AP SP S V S T +A L PP++ S P P M
Sbjct: 404 PPSPPVQAPFSPPASPPVSPSATPP---SQAPPSLAAPPLQVPPSPP--------ASPPM 452
Query: 954 LSPTSTLAPALLPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPS 1013
SP++T P P LA P P P +P P L T P A LP+ + P + P
Sbjct: 453 -SPSATPPPQAPPPLAAPPLQLAKPPPQAP--PALAT---PPLQA-LPSPPASFPGQAPF 505
Query: 1014 GP 1015
P
Sbjct: 506 SP 507
Score = 32.3 bits (72), Expect = 5.7
Identities = 27/99 (27%), Positives = 36/99 (36%), Gaps = 13/99 (13%)
Query: 898 PLSAPPSPAKSSSVDSSHTSG---------RLHEEARRRLPHPPIRHQVSTPILALSGGL 948
PL APPSP S + T L + P PP++ S P
Sbjct: 365 PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS 424
Query: 949 GEPRMLSPTSTLAPAL----LPALAPTPAPALAPVPVSP 983
P +P S AP L P +P +P+ P P +P
Sbjct: 425 ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 463
Score = 32.0 bits (71), Expect = 7.4
Identities = 67/301 (22%), Positives = 102/301 (33%), Gaps = 79/301 (26%)
Query: 871 ERKKAKAAMASLVRRPSARR----LERPRGAPLSAPP-SPAKSSSVDSSHTSGRLHEEAR 925
+R KAKA A+ R P+AR RP G+P PP +PA + ++ GR
Sbjct: 4 KRDKAKAGAAA--RTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGR------ 55
Query: 926 RRLPHPPIRHQVSTPILALSGGLG-------EPRMLSPTSTLAPALLPALAPTPAPALAP 978
P+ +GG+G PR ++ PA PA +P
Sbjct: 56 -------------KPLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSP 102
Query: 979 VPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPE-----------RGHHSPAPARA 1027
PVS P + + GP G + RG + AP R+
Sbjct: 103 GPVSS-----------------PGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
Query: 1028 RLWRALSVAVEKSRAGENEMDAEDAHHQR-EANDVDEDRPKIFPKSHSLKAPVQQGSMRS 1086
ALS + +G A +R A + P+ P + P +G +S
Sbjct: 146 ----ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR--PAPSARPRPPTEGPRKS 199
Query: 1087 LGLAIKALTRSRSTYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQAALIP 1146
+ S+ E + E SP + +AG + P+ +S A P
Sbjct: 200 V-----------SSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGP 248
Query: 1147 S 1147
S
Sbjct: 249 S 249
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 48.1 bits (113), Expect = 1e-04
Identities = 114/546 (20%), Positives = 207/546 (37%), Gaps = 110/546 (20%)
Query: 792 RKLAKKASRTESRES------VEGPPALGFRSASAHNLTVGERLPRARPASLQKSLSVAS 845
+K KKAS ++S +S V+GPPA + A+ VG LP
Sbjct: 76 KKAKKKASSSDSEDSSEEEEEVQGPPA---KKAAVPAKRVG--LPPG------------- 117
Query: 846 SREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSP 905
KA AS++ E + E++KK ++ +P+ APP
Sbjct: 118 ---KAAAKASESSSSEESSDDDDEEDQKKQPV-----------QKGVKPQAKAAKAPPKK 163
Query: 906 AKSSSVDSSHTS------------GRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRM 953
AKSS DS +S + +A+ + P P R + P +A
Sbjct: 164 AKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPAR---AAPKIANGKAASSSSS 220
Query: 954 LSPTSTLAPALLPALAPTPAPALAPVPVSPQSP--NLLTYICPWENAELPAKQENVPQEG 1011
S +S+ + A TP + V ++P T ++E + E Q+
Sbjct: 221 SSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKK 280
Query: 1012 PSGPERGHHS-------PAPARARLWRALSVAVEKSRAGENEMDAEDAHHQREANDVDED 1064
P + G +S P P ++ + AVEK + E+ +ED+ + +++ +E
Sbjct: 281 PMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVES---SEDSSDESDSSSEEEK 337
Query: 1065 RPKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYREKESVEESPEGQNSGTAGESMG 1124
+P KA V + + + A + S S+ + +E+P + +GT S
Sbjct: 338 KP-------PTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAP-SKPAGTTKNSSN 389
Query: 1125 AP---SRSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHTSRMLQVCQREGSREQEDRGR 1181
P ++SP + +P A KQ P + L ++ +S + E S +E++ +
Sbjct: 390 KPAVTTKSPAV-KPAAAPKQ----PVGGGQKLLTRKADSSS-----SEEESSSSEEEKTK 439
Query: 1182 RMTQGLGERKAERAGKTGLAMLRQVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVA 1241
+M + K + K L++ +K+ P G ++ S +D +
Sbjct: 440 KM---VATTKPKATAKAALSL-----------PAKQAPQGSRD-------SSSDSDSSSS 478
Query: 1242 EVCPWEVTESETR---QPDSGNKAEICPWETSEGAPESRALRQDPGDSQKKRGEARGKSE 1298
E + ++S + Q +G A P +G ES S+++ + +GK
Sbjct: 479 EEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGS 538
Query: 1299 PIDVVP 1304
P P
Sbjct: 539 PRPQAP 544
Score = 35.8 bits (81), Expect = 0.51
Identities = 85/423 (20%), Positives = 139/423 (32%), Gaps = 64/423 (15%)
Query: 1543 PGHSSPCLDNSSSKAGSQFLCNGGSRATQVCPQEDLRPEAQEATPAKTEICPWEVNERTR 1602
P ++P + N KA S + S ++ +E ++ P K + V T
Sbjct: 202 PARAAPKIANG--KAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATT 259
Query: 1603 EEWTSAQVPRGGESQKDKEKMPGKSEIEDVTAWEKPEGQIQKQEAVGPWESVDPGSFSPQ 1662
S+ +++++K P K+ KP GP+ SV P S P
Sbjct: 260 PTRKSSSSEDSSSDEEEEQKKPMKN---------KP----------GPYSSVPPPSAPPP 300
Query: 1663 PRPQDTERPQTLLQMSGSVGSKAADICPLD---VEENLTAGKAEICPWEVGAGAGEERAL 1719
+ T+ P+ ++ V S D EE KA + A A
Sbjct: 301 KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSK----ATTKPPPAK 356
Query: 1720 GAEAIRKSPNDTGKVSADLGPRERAVTAPEKPQKPTPEWEVACPWGSVGPGACSQHPG-- 1777
A +D+ D P + A T KP V +V P A + P
Sbjct: 357 KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPA----VTTKSPAVKPAAAPKQPVGG 412
Query: 1778 -----TLDADG----PKAGFQELDHMGCRPGEVCPWEAQEAATSEKAKICPWEVSEGTTG 1828
T AD ++ E + P +AA S AK P +G+
Sbjct: 413 GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAP----QGSRD 468
Query: 1829 KGLDQKAGSESAEQREKALEKGRLTSLGEDVSKGMAKLCQQQETICIWENKDLRESPAQA 1888
D + S S+E+ E+ K + + V+ G A + + A+
Sbjct: 469 SSSD--SDSSSSEEEEEKTSKSAVKKKPQKVAGGAA---------------PSKPASAKK 511
Query: 1889 PKISDLPSSMSSEVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGE 1948
K SS S + +E + KG R + +T + AA E E+ +
Sbjct: 512 GKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKK 571
Query: 1949 KTS 1951
K +
Sbjct: 572 KAA 574
Score = 32.0 bits (71), Expect = 7.4
Identities = 66/335 (19%), Positives = 120/335 (35%), Gaps = 39/335 (11%)
Query: 1901 EVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPAADTEEFTTEDGEKTSHELQSVC-- 1958
E +E S E+ + + P T + T + PA E +++ + S E
Sbjct: 320 ESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK 379
Query: 1959 PWETTAPADSVSHLDRQRPDQPKASSQRLVSTGG-----RAADVCPWDVPDAGVYKSDSS 2013
P TT + + + + P A++ + GG R AD + + + +
Sbjct: 380 PAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTK 439
Query: 2014 AKAETCPWEVTER----IPVKGVSR--QDGKGDSQEEKGRAPEKSEPKGVPVQKKPEMAD 2067
T + T + +P K + +D DS E+ K V+KKP+
Sbjct: 440 KMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA-VKKKPQKVA 498
Query: 2068 FRQQEAVCPWESQDGKGLSPQPAP--DASDRSRGSSEAAGSVETRVAEVCLWEVVEAPSA 2125
+ P ++ GK S + D+S+ + GS + + SA
Sbjct: 499 GGAAPSK-PASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKA------NGTSA 551
Query: 2126 KKAEICPWEAGGGAAEEGEQERESQGQGEMFLQKAGPGGTEEHFSKAAAKPREQEAVCPG 2185
A+ G AA+ E+E E + + + + K+G + K ++ EA
Sbjct: 552 LTAQ------NGKAAKNSEEEEEEKKKAAVVVSKSG----------SLKKRKQNEAAKEA 595
Query: 2186 EGTGSGGLLPQSGALDPELKVSPKEAGSMGSRMAE 2220
E + + Q+ P+ K K A S R+ E
Sbjct: 596 ETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVRE 630
>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
precursor [Homo sapiens]
Length = 899
Score = 47.8 bits (112), Expect = 1e-04
Identities = 52/202 (25%), Positives = 88/202 (43%), Gaps = 12/202 (5%)
Query: 443 FRCIALRWVRLLGFAIVYGTIILKLYRVLQLFLSRTAQRS--ALLSSGRLLRRLGLLLLP 500
F C A W+ LGF++ YG++ K++ V +F + ++ L +L +GLL+
Sbjct: 599 FVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGM 658
Query: 501 VLGFLAVW-TVGALERGIQHAPL------VIRGHTPSGRHFYLCHHDRWDYIMVVAELLL 553
+ LA+W V L R I+ + P H + W I + LL
Sbjct: 659 DVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLL 718
Query: 554 LCWGSFLCYATRAV-LSAFHEPRYMGIALHNELLLSAAFHTARFVLVPSLHPDWTLLLFF 612
L G FL Y T++V ++ R +G+A++N +L TA ++ S D
Sbjct: 719 LLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVL--CLITAPVTMILSSQQDAAFAFAS 776
Query: 613 FHTHSTVTTTLALIFIPKFWKL 634
+ TL ++F+PK +L
Sbjct: 777 LAIVFSSYITLVVLFVPKMRRL 798
>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
precursor [Homo sapiens]
Length = 844
Score = 47.8 bits (112), Expect = 1e-04
Identities = 52/202 (25%), Positives = 88/202 (43%), Gaps = 12/202 (5%)
Query: 443 FRCIALRWVRLLGFAIVYGTIILKLYRVLQLFLSRTAQRS--ALLSSGRLLRRLGLLLLP 500
F C A W+ LGF++ YG++ K++ V +F + ++ L +L +GLL+
Sbjct: 544 FVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGM 603
Query: 501 VLGFLAVW-TVGALERGIQHAPL------VIRGHTPSGRHFYLCHHDRWDYIMVVAELLL 553
+ LA+W V L R I+ + P H + W I + LL
Sbjct: 604 DVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLL 663
Query: 554 LCWGSFLCYATRAV-LSAFHEPRYMGIALHNELLLSAAFHTARFVLVPSLHPDWTLLLFF 612
L G FL Y T++V ++ R +G+A++N +L TA ++ S D
Sbjct: 664 LLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVL--CLITAPVTMILSSQQDAAFAFAS 721
Query: 613 FHTHSTVTTTLALIFIPKFWKL 634
+ TL ++F+PK +L
Sbjct: 722 LAIVFSSYITLVVLFVPKMRRL 743
>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
precursor [Homo sapiens]
Length = 961
Score = 47.8 bits (112), Expect = 1e-04
Identities = 52/202 (25%), Positives = 88/202 (43%), Gaps = 12/202 (5%)
Query: 443 FRCIALRWVRLLGFAIVYGTIILKLYRVLQLFLSRTAQRS--ALLSSGRLLRRLGLLLLP 500
F C A W+ LGF++ YG++ K++ V +F + ++ L +L +GLL+
Sbjct: 661 FVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGM 720
Query: 501 VLGFLAVW-TVGALERGIQHAPL------VIRGHTPSGRHFYLCHHDRWDYIMVVAELLL 553
+ LA+W V L R I+ + P H + W I + LL
Sbjct: 721 DVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLL 780
Query: 554 LCWGSFLCYATRAV-LSAFHEPRYMGIALHNELLLSAAFHTARFVLVPSLHPDWTLLLFF 612
L G FL Y T++V ++ R +G+A++N +L TA ++ S D
Sbjct: 781 LLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVL--CLITAPVTMILSSQQDAAFAFAS 838
Query: 613 FHTHSTVTTTLALIFIPKFWKL 634
+ TL ++F+PK +L
Sbjct: 839 LAIVFSSYITLVVLFVPKMRRL 860
>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
precursor [Homo sapiens]
Length = 906
Score = 47.4 bits (111), Expect = 2e-04
Identities = 64/315 (20%), Positives = 115/315 (36%), Gaps = 28/315 (8%)
Query: 356 CLPCPEGCTSCMDATPC------LVEEAAVLRAAVLACQACCMLAIFLSMLVSYRCRRNK 409
C C G D T C +E + + +A +L L+ R
Sbjct: 562 CKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTP 621
Query: 410 RIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKLYR 469
+ +S L +L G L Y F L KP+ C R + L A+ Y ++ K R
Sbjct: 622 VVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNR 681
Query: 470 VLQLFLS---RTAQRSALLSSGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLVIRG 526
+ ++ + R S + +L+ V L V + I P+ I
Sbjct: 682 IARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLI------IMEPPMPILS 735
Query: 527 HTPSGRHFYLCHHDRWDYIMVVAEL----LLLCWGSFLCYATRAVLSAFHEPRYMGIALH 582
+ + +C+ + VVA L LL+ ++ + TR V + F+E +Y+ ++
Sbjct: 736 YPSIKEVYLICNTSN---LGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMY 792
Query: 583 NELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIFIPKFWKLGAPPREEM 642
++ AF F ++ ++ F +VT L +F PK + + A P +
Sbjct: 793 TTCIIWLAFVPIYF------GSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNV 846
Query: 643 VDEVCEDELDLQHSG 657
++ H G
Sbjct: 847 RSAFTTSDVVRMHVG 861
>gi|157364934 fibrosin [Homo sapiens]
Length = 460
Score = 47.4 bits (111), Expect = 2e-04
Identities = 55/175 (31%), Positives = 71/175 (40%), Gaps = 21/175 (12%)
Query: 860 EETYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPL--SAPPSPAKSSSVDSSHTS 917
+E+ R +ER+E A AA A+ +A P+G L P P +
Sbjct: 298 KESVRVKEERKEEAAAAAAAAAAAAAAAAAAATGPQGLHLLFERPRPPPFLGPSPPDRCA 357
Query: 918 GRLHE---EARRRLPHPPIRHQVSTPILALSGGLGEPRM--LSPTSTLAPALLPALAPTP 972
G L A RL PP ++ + G + R+ L P P L LAP P
Sbjct: 358 GFLEPTWLAAPPRLARPPRFYEAGEELTG-PGAVAAARLYGLEPAH---PLLYSRLAPPP 413
Query: 973 APALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGHHSPAPARA 1027
PA A P +P+LL+ P A L A VP PS P RG P PARA
Sbjct: 414 PPAAA-----PGTPHLLSKTPP--GALLGAPPPLVPAPRPSSPPRG---PGPARA 458
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 47.4 bits (111), Expect = 2e-04
Identities = 153/715 (21%), Positives = 241/715 (33%), Gaps = 103/715 (14%)
Query: 756 SSSLQEPEGTPALHKSRSTYDQRREQDPPLLDSLLRRKLAKKASRTESR------ESVEG 809
S +E +P KSRS +RR P+ R RT+SR E E
Sbjct: 162 SREKRERSRSPRRRKSRSPSPRRRSS--PVRRERKRSHSRSPRHRTKSRSPSPAPEKKEK 219
Query: 810 PPALGFRSASAHNLTVGE--------RLPRARPASLQKSLSVASSREKALLMASQAYLEE 861
P L S +V E ++P+ P K S + +K + E+
Sbjct: 220 TPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKK------EKEKEK 273
Query: 862 TYRQAKEREERKKAKAAMASLVRRPSARRLERPRGAPLSAPPSPAKSSSVDSSHTSGRLH 921
T +++ R + + + + RP R R R PSP + S R+
Sbjct: 274 TRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMP 333
Query: 922 EEARRRLPHPPI--RHQVSTPILALSGGLGEPRMLSP--------------TSTLAP-AL 964
R R P+ R + S + S R SP T L+P A
Sbjct: 334 PPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSAS 393
Query: 965 LPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPERGH----- 1019
P P+P P P + SP P ++ + +V SG H
Sbjct: 394 PPRRRHRPSPPATPPPKTRHSPT------PQQSNRTRKSRVSVSPGRTSGKVTKHKGTEK 447
Query: 1020 -HSPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQR---------------EANDVDE 1063
SP+PA LS + E+ + G +M A D+ QR ++ ++
Sbjct: 448 RESPSPAPKPRKVELSES-EEDKGG--KMAAADSVQQRRQYRRQNQQSSSDSGSSSSSED 504
Query: 1064 DRPKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYREKESVEESPEGQNSGTAGESM 1123
+RPK +SH V + S +RS S K E SP G+ +
Sbjct: 505 ERPK---RSHVKNGEVGRRRRHS-------PSRSASPSPRKRQKETSPRGRRRRSPSPPP 554
Query: 1124 GAPSRSPRLGRPKAVSKQAALIPSDDKESLQNQQNAHTSRMLQ-VCQREGSREQEDRGRR 1182
RSP P + P S ++ + + R QR S + R
Sbjct: 555 TRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRT 614
Query: 1183 MTQGLGERKAERAGKTGLAMLRQVSRDKNIKQSKETPVGWQELPKAGLQSLGSADHRVAE 1242
+ +R R+VS KQ + +PV + P S+ HR
Sbjct: 615 ASP---PPPPKRRASPSPPPKRRVSHSPPPKQ-RSSPVTKRRSPSL------SSKHRKGS 664
Query: 1243 VCPWEVTESETRQPDSGNKAEICPW--ETSEGAPESRALRQDPGDSQKKRGEARGKSEPI 1300
E+ + QP+ + P +TS P +R+ S ++R + PI
Sbjct: 665 SPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPP---PVRRGASSSPQRRQSPSPSTRPI 721
Query: 1301 DVVPMMRKKPERLVREQEAVCPWESADRGGLSPGSAPQDPGRIRDKSEAGDSVEARKVEK 1360
V +P+++ ++A P + R S S P K A S +
Sbjct: 722 RRV-SRTPEPKKI---KKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPS 777
Query: 1361 PGWEAAGP--EAHTPDITKAEPCPWEASEGGEDGKPAQEA--VKDLPQEKQKTRK 1411
W A P +A +P + + P + GG+ K ++ KD +K K K
Sbjct: 778 TNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHK 832
Score = 42.7 bits (99), Expect = 0.004
Identities = 77/309 (24%), Positives = 117/309 (37%), Gaps = 39/309 (12%)
Query: 1884 SPAQAP----KISDLPSSMSSEVAEGHSLEATEKGDLRQDPKTGSFPEHITQEKAPAADT 1939
SP+ AP K +LP S +V E EAT D+ + PK PE I + K P+ +
Sbjct: 209 SPSPAPEKKEKTPELPEP-SVKVKEPSVQEATSTSDILKVPK----PEPIPEPKEPSPEK 263
Query: 1940 EEFTTEDGEKTSHELQSVCPWETTAPADSVSHLDRQRPDQPKASSQRLVSTGGRAADVCP 1999
++ EKT +S + + S SH RP + S R S R + P
Sbjct: 264 NSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSH---TRPRRRHRSRSRSYSPRRRPS---P 317
Query: 2000 WDVPDAGVYKSDSSAKAETCPWEVTERIPVK-----GVSRQDGKGDSQEEKGRAPEKSEP 2054
P + + P R PV+ S S + R+P K P
Sbjct: 318 RRRPSP--RRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPP 375
Query: 2055 K--GVPVQK----KPEMADFRQQEAVCPWESQDGKGLSPQPAPDASDRSRGS--SEAAGS 2106
K P +K P + R++ P + K P P S+R+R S S + G
Sbjct: 376 KRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPK-TRHSPTPQQSNRTRKSRVSVSPGR 434
Query: 2107 VETRVAEVCLWEVVEAPS----AKKAEICPWEAGGG----AAEEGEQERESQGQGEMFLQ 2158
+V + E E+PS +K E+ E G AA+ +Q R+ + Q +
Sbjct: 435 TSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSS 494
Query: 2159 KAGPGGTEE 2167
+G + E
Sbjct: 495 DSGSSSSSE 503
Score = 40.8 bits (94), Expect = 0.016
Identities = 97/446 (21%), Positives = 156/446 (34%), Gaps = 65/446 (14%)
Query: 732 RQHSRDSGS-PGHGSLPGSSRRRLLSS-----SLQEPEGTPALHKSRSTYDQRREQDPPL 785
R+ R S S G S SSR R + P T L S S +R PP
Sbjct: 346 RRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPA 405
Query: 786 LDSLLRRKLAKKASRTESRES-VEGPPALGFRSASAHNLTVGERLPRARPASLQKSLSVA 844
R +R+S V P + H T P P + LS +
Sbjct: 406 TPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSES 465
Query: 845 SSREKALLMASQAYLEETYRQAKEREERKKAKAAMASLVRRPSARRLE------RPRGAP 898
+ + A+ + + + + ++ + ++ +S RP ++ R R +P
Sbjct: 466 EEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSP 525
Query: 899 L-SAPPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGLGEPRMLSPT 957
SA PSP K S GR RRR P PP + +P S R +PT
Sbjct: 526 SRSASPSPRKRQKETSPR--GR-----RRRSPSPPPTRRRRSP----SPAPPPRRRRTPT 574
Query: 958 STLAPALLPALAPTPAPALAPVPVSPQSPNLLTYICPWENAELPAKQENVPQEGPSGPER 1017
P TP+P P +SP+ Y P + P+ P P +
Sbjct: 575 P-------PPRRRTPSP-----PPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPK 622
Query: 1018 GHHSPAPARARLW------RALSVAVEKSR----AGENEMDAEDAHHQREANDVDED--- 1064
SP+P R + S V K R + ++ + + REA +
Sbjct: 623 RRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRH 682
Query: 1065 ----RPKIFPKSHSLKAPVQQGSMRS---------LGLAIKALTRSRSTYREKESVEESP 1111
RP+ P++ S PV++G+ S I+ ++R+ + K++ SP
Sbjct: 683 SPSPRPRA-PQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSP 741
Query: 1112 EGQNSGTAGESMGAPSRSPRLGRPKA 1137
+ ++ S+ S P +P A
Sbjct: 742 QSVRRVSSSRSVSG-SPEPAAKKPPA 766
Score = 33.5 bits (75), Expect = 2.5
Identities = 79/401 (19%), Positives = 142/401 (35%), Gaps = 40/401 (9%)
Query: 1038 EKSRAGENEMDAEDAHHQREANDVDEDRPKIFPKSHSLKAPVQQGSMRSLGLAIKALTRS 1097
++ + ++ + E + +RE + R P +PV++ RS + + T+S
Sbjct: 148 DEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKS 207
Query: 1098 RS---TYREKESVEESPEGQNSGTAGESMGAPSRSPRLGRPKAVSKQAALIPSDDKESLQ 1154
RS +KE E PE A S S L PK PS +K S +
Sbjct: 208 RSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKK 267
Query: 1155 NQQNAHTSRMLQVCQREGSREQEDRGRRMTQGLGERKAERAGKTGLAMLRQVSRDKNIKQ 1214
++ T + R S+ + R R+ R+ + R+ S +
Sbjct: 268 EKEKEKT----RPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSP 323
Query: 1215 SKETPVGWQELPKAGLQSLGSADHRVAEVCPWEVTESETRQPDSGNKAEICPWETSEGAP 1274
+ TP P +S R + S + S + + P TS +P
Sbjct: 324 RRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTS--SP 381
Query: 1275 ESRALRQDPGDSQKKRGEARGKSEPIDVVPMMRKKP-----ERLVREQEAVCPWESADR- 1328
+ R P S +R S P P R P R + + +V P ++ +
Sbjct: 382 PRKTRRLSPSASPPRR--RHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKV 439
Query: 1329 -------GGLSPGSAPQDPGRIR---------DKSEAGDSVEARKVEKPGWEAAGPEAHT 1372
SP AP+ P ++ K A DSV+ R+ + + + ++ +
Sbjct: 440 TKHKGTEKRESPSPAPK-PRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGS 498
Query: 1373 PDITKAEPCPWEASEGGEDGK-----PAQEAVKDLPQEKQK 1408
++ E + GE G+ P++ A P+++QK
Sbjct: 499 SSSSEDERPKRSHVKNGEVGRRRRHSPSRSA-SPSPRKRQK 538
>gi|38201621 eukaryotic translation initiation factor 4 gamma, 1
isoform 1 [Homo sapiens]
Length = 1599
Score = 46.6 bits (109), Expect = 3e-04
Identities = 66/281 (23%), Positives = 103/281 (36%), Gaps = 60/281 (21%)
Query: 891 LERPRGAP--LSAPPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGL 948
+ R G P LS P+P ++ T + E+ P+ Q TP+ + + +
Sbjct: 303 ISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESE--FSSSPL--QAPTPLASHTVEI 358
Query: 949 GEPRMLSPTSTLAPAL--LPALAPTPA-PALAPVPVSP--QSPNLL--------TYICPW 995
EP + P+ L P + P LAP PA P+ +PVP++P Q LL + P
Sbjct: 359 HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPV 418
Query: 996 ENAELPAKQENVPQEGPSGPERGHHSPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQ 1055
E AK+ P+ P S PA A S A E EM+ E+ +
Sbjct: 419 SEPEEQAKEVTASMAPPTIP-----SATPATA--------PSATSPAQEEEMEEEEEEEE 465
Query: 1056 REANDVDEDR----------PKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYREKE 1105
EA + E P+ P +L ++ + + +++ R +KE
Sbjct: 466 GEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKE 525
Query: 1106 SV------------------EESPEGQNSGTAGESMGAPSR 1128
+V + P G N G E G P R
Sbjct: 526 AVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPR 566
>gi|38201627 eukaryotic translation initiation factor 4 gamma, 1
isoform 2 [Homo sapiens]
Length = 1512
Score = 46.6 bits (109), Expect = 3e-04
Identities = 66/281 (23%), Positives = 103/281 (36%), Gaps = 60/281 (21%)
Query: 891 LERPRGAP--LSAPPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGL 948
+ R G P LS P+P ++ T + E+ P+ Q TP+ + + +
Sbjct: 216 ISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESE--FSSSPL--QAPTPLASHTVEI 271
Query: 949 GEPRMLSPTSTLAPAL--LPALAPTPA-PALAPVPVSP--QSPNLL--------TYICPW 995
EP + P+ L P + P LAP PA P+ +PVP++P Q LL + P
Sbjct: 272 HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPV 331
Query: 996 ENAELPAKQENVPQEGPSGPERGHHSPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQ 1055
E AK+ P+ P S PA A S A E EM+ E+ +
Sbjct: 332 SEPEEQAKEVTASMAPPTIP-----SATPATA--------PSATSPAQEEEMEEEEEEEE 378
Query: 1056 REANDVDEDR----------PKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYREKE 1105
EA + E P+ P +L ++ + + +++ R +KE
Sbjct: 379 GEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKE 438
Query: 1106 SV------------------EESPEGQNSGTAGESMGAPSR 1128
+V + P G N G E G P R
Sbjct: 439 AVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPR 479
>gi|38201625 eukaryotic translation initiation factor 4 gamma, 1
isoform 3 [Homo sapiens]
Length = 1435
Score = 46.6 bits (109), Expect = 3e-04
Identities = 66/281 (23%), Positives = 103/281 (36%), Gaps = 60/281 (21%)
Query: 891 LERPRGAP--LSAPPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGL 948
+ R G P LS P+P ++ T + E+ P+ Q TP+ + + +
Sbjct: 139 ISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESE--FSSSPL--QAPTPLASHTVEI 194
Query: 949 GEPRMLSPTSTLAPAL--LPALAPTPA-PALAPVPVSP--QSPNLL--------TYICPW 995
EP + P+ L P + P LAP PA P+ +PVP++P Q LL + P
Sbjct: 195 HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPV 254
Query: 996 ENAELPAKQENVPQEGPSGPERGHHSPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQ 1055
E AK+ P+ P S PA A S A E EM+ E+ +
Sbjct: 255 SEPEEQAKEVTASMAPPTIP-----SATPATA--------PSATSPAQEEEMEEEEEEEE 301
Query: 1056 REANDVDEDR----------PKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYREKE 1105
EA + E P+ P +L ++ + + +++ R +KE
Sbjct: 302 GEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKE 361
Query: 1106 SV------------------EESPEGQNSGTAGESMGAPSR 1128
+V + P G N G E G P R
Sbjct: 362 AVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPR 402
>gi|38201623 eukaryotic translation initiation factor 4 gamma, 1
isoform 1 [Homo sapiens]
Length = 1599
Score = 46.6 bits (109), Expect = 3e-04
Identities = 66/281 (23%), Positives = 103/281 (36%), Gaps = 60/281 (21%)
Query: 891 LERPRGAP--LSAPPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGL 948
+ R G P LS P+P ++ T + E+ P+ Q TP+ + + +
Sbjct: 303 ISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESE--FSSSPL--QAPTPLASHTVEI 358
Query: 949 GEPRMLSPTSTLAPAL--LPALAPTPA-PALAPVPVSP--QSPNLL--------TYICPW 995
EP + P+ L P + P LAP PA P+ +PVP++P Q LL + P
Sbjct: 359 HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPV 418
Query: 996 ENAELPAKQENVPQEGPSGPERGHHSPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQ 1055
E AK+ P+ P S PA A S A E EM+ E+ +
Sbjct: 419 SEPEEQAKEVTASMAPPTIP-----SATPATA--------PSATSPAQEEEMEEEEEEEE 465
Query: 1056 REANDVDEDR----------PKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYREKE 1105
EA + E P+ P +L ++ + + +++ R +KE
Sbjct: 466 GEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKE 525
Query: 1106 SV------------------EESPEGQNSGTAGESMGAPSR 1128
+V + P G N G E G P R
Sbjct: 526 AVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPR 566
>gi|38201619 eukaryotic translation initiation factor 4 gamma, 1
isoform 4 [Homo sapiens]
Length = 1403
Score = 46.6 bits (109), Expect = 3e-04
Identities = 66/281 (23%), Positives = 103/281 (36%), Gaps = 60/281 (21%)
Query: 891 LERPRGAP--LSAPPSPAKSSSVDSSHTSGRLHEEARRRLPHPPIRHQVSTPILALSGGL 948
+ R G P LS P+P ++ T + E+ P+ Q TP+ + + +
Sbjct: 107 ISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESE--FSSSPL--QAPTPLASHTVEI 162
Query: 949 GEPRMLSPTSTLAPAL--LPALAPTPA-PALAPVPVSP--QSPNLL--------TYICPW 995
EP + P+ L P + P LAP PA P+ +PVP++P Q LL + P
Sbjct: 163 HEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPV 222
Query: 996 ENAELPAKQENVPQEGPSGPERGHHSPAPARARLWRALSVAVEKSRAGENEMDAEDAHHQ 1055
E AK+ P+ P S PA A S A E EM+ E+ +
Sbjct: 223 SEPEEQAKEVTASMAPPTIP-----SATPATA--------PSATSPAQEEEMEEEEEEEE 269
Query: 1056 REANDVDEDR----------PKIFPKSHSLKAPVQQGSMRSLGLAIKALTRSRSTYREKE 1105
EA + E P+ P +L ++ + + +++ R +KE
Sbjct: 270 GEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKE 329
Query: 1106 SV------------------EESPEGQNSGTAGESMGAPSR 1128
+V + P G N G E G P R
Sbjct: 330 AVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPR 370
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,532,577
Number of Sequences: 37866
Number of extensions: 5879537
Number of successful extensions: 25058
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 708
Number of HSP's that attempted gapping in prelim test: 20943
Number of HSP's gapped (non-prelim): 3773
length of query: 2367
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2248
effective length of database: 13,741,464
effective search space: 30890811072
effective search space used: 30890811072
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.