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Search of human proteins with 92087060
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
(588 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 1205 0.0
gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1... 456 e-128
gi|18390333 ankyrin repeat and SOCS box-containing 14 isoform 2 ... 332 6e-91
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 325 7e-89
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 189 8e-48
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 159 7e-39
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 150 4e-36
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 146 5e-35
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 146 5e-35
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 143 5e-34
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 139 7e-33
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 139 7e-33
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 139 7e-33
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 139 7e-33
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 139 7e-33
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 130 3e-30
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 127 2e-29
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 120 3e-27
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 119 1e-26
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 118 2e-26
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 115 9e-26
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 115 1e-25
gi|34304381 inversin isoform a [Homo sapiens] 114 3e-25
gi|34304379 inversin isoform b [Homo sapiens] 114 3e-25
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 114 3e-25
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 114 3e-25
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 107 2e-23
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 105 9e-23
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 105 9e-23
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 105 9e-23
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 1205 bits (3118), Expect = 0.0
Identities = 588/588 (100%), Positives = 588/588 (100%)
Query: 1 MDTNDDPDEDHLTSYDIQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQ 60
MDTNDDPDEDHLTSYDIQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQ
Sbjct: 1 MDTNDDPDEDHLTSYDIQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQ 60
Query: 61 EYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVK 120
EYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVK
Sbjct: 61 EYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVK 120
Query: 121 AGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSA 180
AGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSA
Sbjct: 121 AGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSA 180
Query: 181 MHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALA 240
MHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALA
Sbjct: 181 MHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALA 240
Query: 241 DDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTS 300
DDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTS
Sbjct: 241 DDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTS 300
Query: 301 KNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSN 360
KNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSN
Sbjct: 301 KNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSN 360
Query: 361 NDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPS 420
NDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPS
Sbjct: 361 NDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPS 420
Query: 421 VIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVWSEIQEEVLPGWTSCVIKDNP 480
VIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVWSEIQEEVLPGWTSCVIKDNP
Sbjct: 421 VIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVWSEIQEEVLPGWTSCVIKDNP 480
Query: 481 FCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHL 540
FCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHL
Sbjct: 481 FCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHL 540
Query: 541 CRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT 588
CRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT
Sbjct: 541 CRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT 588
>gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1
[Homo sapiens]
Length = 423
Score = 456 bits (1172), Expect = e-128
Identities = 226/425 (53%), Positives = 293/425 (68%), Gaps = 9/425 (2%)
Query: 159 MVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAA 218
M + LI + ++ C +A+HEAAK GR+D+V L+L G + + +G TPL +AA
Sbjct: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
Query: 219 EYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHL 278
+ GH +++E L+ KG + A D +S+L EAA GGNPD ++LLLEYG N+P +GHL
Sbjct: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
Query: 279 PIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLL 338
PIH AA GH LALK LIPVT AI++SG++P+H AA G + QCLELLI+ GFDVN +L
Sbjct: 121 PIHVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 180
Query: 339 ADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRL 398
I++ YDD RK+ALYF VSN+D+ ++LL+AGA PN DP+NCL +A+R NYE++ L
Sbjct: 181 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISL 240
Query: 399 LLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSF 458
LL HGANVN YF VN FPS +QY L DEVMLR+LLN GY E CFDC HGD S+
Sbjct: 241 LLRHGANVN-YFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSY 299
Query: 459 VWSEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSAL 518
+ GWTS VIKD FCE IT+ W++HL G+V RV++DY+D V +C+KLK+ L
Sbjct: 300 --------TVEGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVL 351
Query: 519 EVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEY 578
+ Q W EI IL NP SLKHLCRLKIR+ MG L P + LPLP ++ Y+L+KEY
Sbjct: 352 QKQGIWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEY 411
Query: 579 DLYGQ 583
DLYGQ
Sbjct: 412 DLYGQ 416
>gi|18390333 ankyrin repeat and SOCS box-containing 14 isoform 2
[Homo sapiens]
Length = 302
Score = 332 bits (851), Expect = 6e-91
Identities = 166/293 (56%), Positives = 208/293 (70%), Gaps = 9/293 (3%)
Query: 291 ALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDER 350
ALK LIPVT AI++SG++P+H AA G + QCLELLI+ GFDVN +L I++ YDD R
Sbjct: 12 ALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHR 71
Query: 351 KTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYF 410
K+ALYF VSN+D+ ++LL+AGA PN DP+NCL +A+R NYE++ LLL HGANVN YF
Sbjct: 72 KSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVN-YF 130
Query: 411 MHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVWSEIQEEVLPG 470
VN FPS +QY L DEVMLR+LLN GY E CFDC HGD S+ + G
Sbjct: 131 CRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSY--------TVEG 182
Query: 471 WTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQI 530
WTS VIKD FCE IT+ W++HL G+V RV++DY+D V +C+KLK+ L+ Q W EI I
Sbjct: 183 WTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFI 242
Query: 531 LENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQ 583
L NP SLKHLCRLKIR+ MG L P + LPLP ++ Y+L+KEYDLYGQ
Sbjct: 243 LTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQ 295
Score = 37.4 bits (85), Expect = 0.039
Identities = 38/138 (27%), Positives = 65/138 (47%), Gaps = 16/138 (11%)
Query: 74 EKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF-----KTCDG--ETPLTLAVKAGLVEN 126
+ G P+H A Q LE+++ A + + K D ++ L AV + +
Sbjct: 27 QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS 86
Query: 127 VRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMH--EA 184
V+ LL G PN L IA++ G+Y+++S L++H +++ C R + +H A
Sbjct: 87 VKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNYFC--RVNPLHFPSA 141
Query: 185 AKQGRKDIVAL--LLKHG 200
+ KD V L LL +G
Sbjct: 142 LQYTLKDEVMLRMLLNYG 159
Score = 30.0 bits (66), Expect = 6.2
Identities = 23/90 (25%), Positives = 45/90 (50%), Gaps = 6/90 (6%)
Query: 115 LTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPC 174
L L ++AG +V +L++ + + +D ++ L AV V L+ +Q
Sbjct: 45 LELLIQAGF--DVNFMLDQRINKHY-DDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDP 101
Query: 175 VKRWSAMHEAAKQGRKDIVALLLKHGGNVH 204
V + + A + G ++++LLL+HG NV+
Sbjct: 102 V---NCLQIALRMGNYELISLLLRHGANVN 128
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 325 bits (833), Expect = 7e-89
Identities = 183/532 (34%), Positives = 300/532 (56%), Gaps = 10/532 (1%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L++AIK G L+ +K + E +++GW PLHEA L+ VL +Y +
Sbjct: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK-VLQRAYPGTIDQ 119
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
+T ET + LA G ++ + +LL+ G P+ N ETPL A ++ + + V L++H
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
N + C + W+A+HE+ + +++ +L+ G V ++ +G+TPL VAA+ G + L
Sbjct: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE 286
L G D+ A D AS L+EA + + + LL G N N+ G LP+H A+ +
Sbjct: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
Query: 287 GHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSY 346
G+Y ++ L+PVTS+ IR+SG++P+H AA+ + + LE L+ FDVNT LA ++ Y
Sbjct: 300 GNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359
Query: 347 DDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANV 406
+D R +ALYF V NN+V+ TE+LL GADPN D ++ LLVA+R ++LLL HGAN+
Sbjct: 360 EDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANI 419
Query: 407 NCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVW--SEIQ 464
+ Y + T FP+ I +A+ +L+ L++ G E CF C++G+ S
Sbjct: 420 DAYIA-THPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFN 478
Query: 465 EEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREW 524
+ V++ FCEF++ P + G + VL+DY+ V LC++LK ++ +W
Sbjct: 479 DAPAADKEPSVVQ---FCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDW 535
Query: 525 PEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFK 576
I++ E P L HLCRL++R+ +G ++ ++ LPLP + RY+ ++
Sbjct: 536 AVIKEKAEPPRPLAHLCRLRVRKAIGKYRI---KLLDTLPLPGRLIRYLKYE 584
Score = 93.2 bits (230), Expect = 6e-19
Identities = 74/262 (28%), Positives = 119/262 (45%), Gaps = 20/262 (7%)
Query: 147 PLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLK-HGGNVHL 205
PL+ A+K G + + T+IK +L +P + W +HEAA G+ + +L + + G +
Sbjct: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
Query: 206 RDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEY 265
R T + +A GH D L L+ G + + L++A N + + +L+++
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
Query: 266 GGSGNVPNRAGHLPIHRAAYEGHYLALKYLI----PVTSKNAIRKSGLTPIHSAADGQNA 321
N G +H + ++ L+ V SKNA G+TP+ AA
Sbjct: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAY---GITPLFVAAQSGQL 236
Query: 322 QCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGAD---PNL 378
+ L L + G D+NT +D+ S ALY N E LL+ GAD N
Sbjct: 237 EALRFLAKYGADINTQASDNAS---------ALYEACKNEHEEVVEFLLSQGADANKTNK 287
Query: 379 DPLNCLLVAVRANNYEIVRLLL 400
D L L +A + NY IV++LL
Sbjct: 288 DGLLPLHIASKKGNYRIVQMLL 309
Score = 60.5 bits (145), Expect = 4e-09
Identities = 50/202 (24%), Positives = 86/202 (42%), Gaps = 47/202 (23%)
Query: 244 ASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGH--------------- 288
A L +A G+ + + +++ G + PN+ G LP+H AAY G
Sbjct: 58 ADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTI 117
Query: 289 -----------YLA---------LKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLI 328
YLA L L + KS TP++ A + +NA+ +++L+
Sbjct: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
Query: 329 ENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGA---DPNLDPLNCLL 385
++ D N + TAL+ VS ND+ ++L++ GA N + L
Sbjct: 178 QHNADTNHRC---------NRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLF 228
Query: 386 VAVRANNYEIVRLLLSHGANVN 407
VA ++ E +R L +GA++N
Sbjct: 229 VAAQSGQLEALRFLAKYGADIN 250
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 189 bits (479), Expect = 8e-48
Identities = 147/538 (27%), Positives = 260/538 (48%), Gaps = 62/538 (11%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDA-SYKTLWEFKT 108
A ++G++ L++ +K ++D AD +GW P+HEA + L+++++A S + + KT
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
Query: 109 CDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNT 168
+G L LA G + V+ LLE G PN + TPL +AV+ G D++ L++H
Sbjct: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
Query: 169 SLD-QPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLE 227
+++ + W+++H+A+ Q +I+ LLL+ G N +D FG+TPL VAA+YG + L
Sbjct: 137 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 196
Query: 228 HLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV--PNRAGHLPIHRAAY 285
LI G +V A D A+ LF AA G+ C+ LLL G ++ + LPIH AA
Sbjct: 197 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQ 256
Query: 286 EGHYLALKYLIPVTSKNA-IRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQ 344
GH L LIP+T++ + ++P++SA G + CLE+L+ NG
Sbjct: 257 MGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG------------- 303
Query: 345 SYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGA 404
Y + + L FG S+ P+ C+ + IV +LL +GA
Sbjct: 304 -YSPDAQACLVFGFSS-------------------PV-CMAFQKDCEFFGIVNILLKYGA 342
Query: 405 NVNCYFMHVNDTRFPSVIQYALNDE--VMLRLLLNNGYQV---EMCFDCMHGDIFGNSFV 459
+N +H + Y L E + R L G + ++ ++ I +
Sbjct: 343 QIN--ELH---------LAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKY 391
Query: 460 WSEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALE 519
+ ++ G+ ++ N + + +++ + T ++ P ++ SA
Sbjct: 392 KEWLPHLLVAGFDPLILLCNSWIDSVSIDTL-----IFTLEFTNWKTLAPAVERMLSA-R 445
Query: 520 VQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKE 577
W ++Q + SL HLCRL+IR + ++L + + +LPLP ++ Y+L+++
Sbjct: 446 ASNAW-ILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 502
Score = 86.3 bits (212), Expect = 7e-17
Identities = 61/234 (26%), Positives = 112/234 (47%), Gaps = 14/234 (5%)
Query: 150 IAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGN---VHLR 206
+A ++G+ ++ L+K S+D + W +HEAA + + +L+ + + ++
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 207 DGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYG 266
G L +AA GH +++ L+ G D A + + LF A G D + LLL++G
Sbjct: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
Query: 267 GSGN-VPNRAGHLPIHRAAYEGHYLALKYLI-PVTSKNAIRKSGLTPIHSAADGQNAQCL 324
+ N + G +H+A+++ + +K L+ +K G+TP+ AA + L
Sbjct: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
Query: 325 ELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNL 378
+LI +G +VN D + T L+ C E+LL++GADP+L
Sbjct: 196 SILISSGANVNCQALD---------KATPLFIAAQEGHTKCVELLLSSGADPDL 240
Score = 67.4 bits (163), Expect = 4e-11
Identities = 61/233 (26%), Positives = 102/233 (43%), Gaps = 18/233 (7%)
Query: 214 LGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGN--- 270
+G+AA G+ VL L+ KG V + G + EAA + +C+ +L+ S N
Sbjct: 14 VGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
Query: 271 VPNRAGHLPIHRAAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIE 329
+ G +H AA +GH+ ++ L+ NA TP+ A + L LL++
Sbjct: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
Query: 330 NGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDP---LNCLLV 386
+G +VN H ++ +L+ + ++LL GA+ + L V
Sbjct: 134 HGANVN---GSHSMCGWN-----SLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFV 185
Query: 387 AVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNG 439
A + E + +L+S GANVNC + D P I + LLL++G
Sbjct: 186 AAQYGKLESLSILISSGANVNCQAL---DKATPLFIAAQEGHTKCVELLLSSG 235
Score = 67.0 bits (162), Expect = 5e-11
Identities = 56/175 (32%), Positives = 80/175 (45%), Gaps = 17/175 (9%)
Query: 242 DGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPV-TS 300
D S + AA GN + LL+ G S +V + G +PIH AAY L+ LI +S
Sbjct: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
Query: 301 KNAIRK---SGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFG 357
+N I+ G +H AA + + +++L+E G D N E T L+
Sbjct: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL---------EETTPLFLA 119
Query: 358 VSNNDVHCTEVLLAAGADPN----LDPLNCLLVAVRANNYEIVRLLLSHGANVNC 408
V N + +LL GA+ N + N L A N EI++LLL GAN C
Sbjct: 120 VENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC 174
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 159 bits (402), Expect = 7e-39
Identities = 131/480 (27%), Positives = 225/480 (46%), Gaps = 61/480 (12%)
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
KT +G L LA G + V+ LLE G PN + TPL +AV+ G D++ L++H
Sbjct: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
Query: 167 NTSLD-QPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
+++ + W+++H+A+ Q +I+ LLL+ G N +D FG+TPL VAA+YG +
Sbjct: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV--PNRAGHLPIHRA 283
L LI G +V A D A+ LF AA G+ C+ LLL G ++ + LPIH A
Sbjct: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
Query: 284 AYEGHYLALKYLIPVTSKNA-IRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHI 342
A GH L LIP+T++ + ++P++SA G + CLE+L+ NG
Sbjct: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG----------- 230
Query: 343 SQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSH 402
Y + + L FG S+ P+ C+ + IV +LL +
Sbjct: 231 ---YSPDAQACLVFGFSS-------------------PV-CMAFQKDCEFFGIVNILLKY 267
Query: 403 GANVNCYFMHVNDTRFPSVIQYALNDE--VMLRLLLNNGYQV---EMCFDCMHGDIFGNS 457
GA +N +H + Y L E + R L G + ++ ++ I +
Sbjct: 268 GAQIN--ELH---------LAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQA 316
Query: 458 FVWSEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSA 517
+ ++ G+ ++ N + + +++ + T ++ P ++ SA
Sbjct: 317 KYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTL-----IFTLEFTNWKTLAPAVERMLSA 371
Query: 518 LEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKE 577
W ++Q + SL HLCRL+IR + ++L + + +LPLP ++ Y+L+++
Sbjct: 372 -RASNAW-ILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 429
Score = 60.1 bits (144), Expect = 6e-09
Identities = 51/222 (22%), Positives = 94/222 (42%), Gaps = 38/222 (17%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEK-GWFPLHEAVVQPIQQILEIVLDASYKTLWEFKT 108
A++ G I L+ +++ ++ + GW LH+A Q +I+++
Sbjct: 46 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKL-------------- 91
Query: 109 CDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNT 168
LL KG ++D G TPL +A + G + +S LI
Sbjct: 92 ---------------------LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGA 130
Query: 169 SLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGG--NVHLRDGFGVTPLGVAAEYGHCDVL 226
+++ + + + + AA++G V LLL G +++ + P+ AA+ GH +L
Sbjct: 131 NVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 190
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGS 268
+ LI + S ++ A GG+ DC+ +LL G S
Sbjct: 191 DLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYS 232
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 150 bits (378), Expect = 4e-36
Identities = 105/364 (28%), Positives = 187/364 (51%), Gaps = 25/364 (6%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A K+GH+ + E ++ + +D A +KG LH A + +++++++ ++
Sbjct: 81 ASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANV--NAQSQ 138
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
+G TPL +A + +E V+ LL+ G + + G TPL +A+++G +VS L++++T
Sbjct: 139 NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTK 198
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
R A+H AA++ ALLL++ N + G TPL +AA YG+ +V L
Sbjct: 199 ----GKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLL 254
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+++ V A + + L A+ GN + + LLL+ G + R G P+H A GH
Sbjct: 255 LNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHE 314
Query: 290 LALKYLI----PVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQS 345
++ L+ P+ SK K+GL+P+H A G + C++LL+++ V+ + D++
Sbjct: 315 QVVEMLLDRAAPILSKT---KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL--- 368
Query: 346 YDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSH 402
TAL+ +VLL A+PN LN L +A + N +++ LLL H
Sbjct: 369 ------TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH 422
Query: 403 GANV 406
GA++
Sbjct: 423 GASI 426
Score = 135 bits (340), Expect = 1e-31
Identities = 101/358 (28%), Positives = 163/358 (45%), Gaps = 15/358 (4%)
Query: 54 GHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGET 113
GH+ + + + + + + + +G LH A +++ ++ + E K D +T
Sbjct: 444 GHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV--EAKAKDDQT 501
Query: 114 PLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQP 173
PL ++ + G + V+ LL++G PN G TPL ++ ++G D+ + L+ H SL
Sbjct: 502 PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSIT 561
Query: 174 CVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKG 233
K ++ +H AAK G+ ++ LLL+ + G+TPL VAA Y + V L+ +G
Sbjct: 562 TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621
Query: 234 GDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALK 293
A A +G + L AA D + LLEYG N R G +H AA EGH +
Sbjct: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVS 681
Query: 294 YLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKT 352
L+ + N KSGLTP+H AA E+L+ G V+ Y T
Sbjct: 682 LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA----QTKMGY-----T 732
Query: 353 ALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGANVN 407
L+ G ++ LL A N N L A + + I+ +LL + A+ N
Sbjct: 733 PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Score = 126 bits (317), Expect = 5e-29
Identities = 101/362 (27%), Positives = 159/362 (43%), Gaps = 30/362 (8%)
Query: 74 EKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEK 133
+ G PLH A ++++L + + T D T L +A G + + LL+K
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPV--DDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 134 GVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIV 193
PN K G TPL IA KK ++ L+KH S+ + +H AA G +IV
Sbjct: 390 KANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
+ L+ HG + + + G T L +AA G +V+ +L+ G V A A D + L +A
Sbjct: 450 SQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARL 509
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIP-VTSKNAIRKSGLTPI 312
G D + LL+ G S N +G+ P+H +A EGH +L+ S + K G TP+
Sbjct: 510 GKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569
Query: 313 HSAADGQNAQCLELLIENGFDVNT-----LLADHISQSYDDER----------------- 350
H AA + LL++ + L H++ YD+++
Sbjct: 570 HVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK 629
Query: 351 --KTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGAN 405
T L+ N + LL GAD N + + +A + + ++V LLL AN
Sbjct: 630 NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 689
Query: 406 VN 407
VN
Sbjct: 690 VN 691
Score = 118 bits (296), Expect = 1e-26
Identities = 99/397 (24%), Positives = 175/397 (44%), Gaps = 22/397 (5%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L A ++ H+ ++ + + A E G+ PL A+ Q Q++ ++L+ K
Sbjct: 144 LYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRL 203
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
L +A + + LL+ + ++ G TPL IA G+ ++ + L+
Sbjct: 204 PA------LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
++D + +H A+K+G ++V LLL G + + G+TPL A GH V+
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE 286
E L+ + +L+ +G S L A G + +C+ LLL++ + +H AA+
Sbjct: 318 EMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHC 377
Query: 287 GHYLALKYLI-PVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQS 345
GHY K L+ + NA +G TP+H A + +ELL+++G + Q+
Sbjct: 378 GHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASI---------QA 428
Query: 346 YDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPL---NCLLVAVRANNYEIVRLLLSH 402
+ T ++ V+ L+ GA PN + L +A R+ E+VR L+
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
Query: 403 GANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNG 439
GA V D + P I L +++ LL G
Sbjct: 489 GAQVEA---KAKDDQTPLHISARLGKADIVQQLLQQG 522
Score = 111 bits (278), Expect = 2e-24
Identities = 94/355 (26%), Positives = 156/355 (43%), Gaps = 30/355 (8%)
Query: 79 PLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPN 138
PLH A + +++++LD K + KT DG TPL ++G + V LL++
Sbjct: 271 PLHVASKRGNANMVKLLLDRGAKI--DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
Query: 139 TKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLK 198
+K G +PL +A + + V L++HN +D +A+H AA G + +LL
Sbjct: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD 388
Query: 199 HGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDC 258
N + + G TPL +A + V+E L+ G + A+ + G + + AA G+ +
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
Query: 259 ISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPIHSAAD 317
+S L+ +G S N N G +H AA G ++YL+ ++ A K TP+H +A
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
Query: 318 GQNAQCLELLIENGF----------------------DVNTLLADHISQSYDDERK--TA 353
A ++ L++ G DV L DH + +K T
Sbjct: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
Query: 354 LYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGAN 405
L+ + +LL A P+ L L VA +N ++ LLL GA+
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGAS 623
Score = 108 bits (270), Expect = 1e-23
Identities = 93/394 (23%), Positives = 169/394 (42%), Gaps = 60/394 (15%)
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
K D A +AG +E ++ GV N N G L +A K+G ++VS L++
Sbjct: 37 KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
++D K +A+H A+ G+ ++V +L+ +G NV+ + G TPL +AA+ H +V+
Sbjct: 97 EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSG----------------- 269
+ L+ G +DG + L A G+ +SLLLE G
Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216
Query: 270 ------------NVPNRAGHLPIHRAAYEGHY-LALKYLIPVTSKNAIRKSGLTPIHSAA 316
+V +++G P+H AA+ G+ +A L + + ++ +TP+H A+
Sbjct: 217 AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVAS 276
Query: 317 DGQNAQCLELLIENGFDVNTLLADHISQSYDDERK------------------------T 352
NA ++LL++ G ++ D ++ + R +
Sbjct: 277 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336
Query: 353 ALYFGVSNNDVHCTEVLLAAGA---DPNLDPLNCLLVAVRANNYEIVRLLLSHGANVNCY 409
L+ + ++C ++LL D D L L VA +Y++ ++LL AN N
Sbjct: 337 PLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK 396
Query: 410 FMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVE 443
+ + P I N ++ LLL +G ++
Sbjct: 397 AL---NGFTPLHIACKKNRIKVMELLLKHGASIQ 427
Score = 90.5 bits (223), Expect = 4e-18
Identities = 68/264 (25%), Positives = 123/264 (46%), Gaps = 3/264 (1%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A K G + ++ + D A + G PLH A Q++ ++LD K
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK-- 629
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
+G TPL +A K ++ TLLE G N +G + +A ++G DMVS L+ N +
Sbjct: 630 NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 689
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
++ + +H AA++ R ++ +L+ G +V + G TPL V YG+ ++ L
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ V A +G + L +AA G+ I++LL+ S N G+ + A G Y
Sbjct: 750 LQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG-Y 808
Query: 290 LALKYLIPVTSKNAIRKSGLTPIH 313
+++ + + ++ + + +T H
Sbjct: 809 ISVVDTLKIVTEETMTTTTVTEKH 832
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 146 bits (369), Expect = 5e-35
Identities = 106/369 (28%), Positives = 192/369 (52%), Gaps = 27/369 (7%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A K+GH+ +QE + ++D A +KG LH A + +++++++ ++
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI--NAQSQ 128
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
+G TPL +A + ++ V+ LLE G +T + G TPL +A+++G V+ L++++T
Sbjct: 129 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 188
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGF--------GVTPLGVAAEYG 221
R A+H AA++ ALLL++ N ++ G TPL +AA YG
Sbjct: 189 ----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244
Query: 222 HCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIH 281
+ +V L+++G V A +G + L A+ GN + + LLL+ GG + R G P+H
Sbjct: 245 NVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH 304
Query: 282 RAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
AA GH ++ L+ + R K+GL+P+H AA G + +C++ L+++ V+ + D
Sbjct: 305 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 364
Query: 341 HISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLVAVRANNYEIVR 397
++ TAL+ T++LL A+PN LN L +A + N +++
Sbjct: 365 YL---------TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVME 415
Query: 398 LLLSHGANV 406
LL+ +GA++
Sbjct: 416 LLVKYGASI 424
Score = 143 bits (360), Expect = 5e-34
Identities = 105/362 (29%), Positives = 173/362 (47%), Gaps = 15/362 (4%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A K+ I ++ VKY ++ E G P+H A I+ ++L +
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP--DVTNI 462
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
GET L +A +AG VE VR LL G + + + +TPL IA + G ++V L++H
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
D ++ +H +A++G+ D+ ++LL+ G L G TPL VAA+YG DV + L
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ + + +G + L AA N LLLE G S + + G+ P+H AA +
Sbjct: 583 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642
Query: 290 LALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDD 348
L+ ++ N + K G+TP+H A+ + + LL++ G ++ H+S
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI------HMSTK--- 693
Query: 349 ERKTALYFGVSNNDVHCTEVLLAAGADPNLDP---LNCLLVAVRANNYEIVRLLLSHGAN 405
T+L+ + V+ ++L GAD + L+VA N ++V LL GAN
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 753
Query: 406 VN 407
VN
Sbjct: 754 VN 755
Score = 115 bits (288), Expect = 1e-25
Identities = 89/309 (28%), Positives = 144/309 (46%), Gaps = 23/309 (7%)
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
K D A +AG ++ V L+ G+ NT N G L +A K+G +V L+
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
+S+D K +A+H A+ G+ ++V +L+K G N++ + G TPL +AA+ H DV+
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE 286
++L+ G + +DG + L A G+ +++LLE G V A H+ + +
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
Query: 287 GHYLALK--YLIPVTSK---NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADH 341
L L+ + V SK N +SG TP+H AA N LL+ G V+ +
Sbjct: 207 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266
Query: 342 ISQSYDDERKTALYFGVSNNDVHCTEVLLAAGAD------PNLDPLNCLLVAVRANNYEI 395
I T L+ + + ++LL G L PL+C A R+ + ++
Sbjct: 267 I---------TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC---AARSGHDQV 314
Query: 396 VRLLLSHGA 404
V LLL GA
Sbjct: 315 VELLLERGA 323
Score = 108 bits (269), Expect = 2e-23
Identities = 94/315 (29%), Positives = 141/315 (44%), Gaps = 17/315 (5%)
Query: 97 DASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGS 156
D K + T G TPL +A G V LL +G + G TPL +A K+G+
Sbjct: 219 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 278
Query: 157 YDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGV 216
+MV L+ +D + +H AA+ G +V LLL+ G + R G++PL +
Sbjct: 279 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHM 338
Query: 217 AAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAG 276
AA+ H + ++HL+ V + D + L AA G+ LLL+ + N G
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG 398
Query: 277 HLPIHRAAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGF--D 333
P+H A + ++ L+ S AI +SGLTPIH AA + + LL++NG D
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 334 VNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRA 390
V + + TAL+ V LL GA + + L +A R
Sbjct: 459 VTNIRGE-----------TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507
Query: 391 NNYEIVRLLLSHGAN 405
EIV+LLL H A+
Sbjct: 508 GKTEIVQLLLQHMAH 522
Score = 108 bits (269), Expect = 2e-23
Identities = 92/341 (26%), Positives = 156/341 (45%), Gaps = 15/341 (4%)
Query: 68 AMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENV 127
A+D G PLH A + +++++LD + + KT DG TPL A ++G + V
Sbjct: 258 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI--DAKTRDGLTPLHCAARSGHDQVV 315
Query: 128 RTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQ 187
LLE+G + G +PL +A + + V L++H +D + +A+H AA
Sbjct: 316 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375
Query: 188 GRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVL 247
G + LLL N + R G TPL +A + V+E L+ G + A+ + G + +
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
Query: 248 FEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTS-KNAIRK 306
AA G+ + + LLL+ G S +V N G +H AA G ++ L+ + +A +
Sbjct: 436 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR 495
Query: 307 SGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCT 366
TP+H A+ + ++LL+++ + + T L+ V
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY---------TPLHISAREGQVDVA 546
Query: 367 EVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGA 404
VLL AGA +L L VA + + ++ +LLL A
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Score = 106 bits (264), Expect = 7e-23
Identities = 72/292 (24%), Positives = 138/292 (47%), Gaps = 3/292 (1%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + G +Q +++ D A G+ PLH + + + ++L+A T
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG--AAHSLATK 561
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
G TPL +A K G ++ + LL++ ++ G TPL +A + + L++ S
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
++ +H AAK+ + I + LL +G ++ GVTPL +A++ GH D++ L
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ KG ++ G + L AA + +L ++G + + G+ P+ A + G+
Sbjct: 682 LDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 741
Query: 290 LALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
+ +L+ + NA K+G TP+H AA + + +L+++G N A+
Sbjct: 742 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTAN 793
Score = 105 bits (261), Expect = 2e-22
Identities = 75/262 (28%), Positives = 125/262 (47%), Gaps = 3/262 (1%)
Query: 52 KQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDG 111
++G + ++ A A +KG+ PLH A + +++L + + +G
Sbjct: 539 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR--RAAADSAGKNG 596
Query: 112 ETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLD 171
TPL +A + LLEKG P+ G TPL IA KK + STL+ + +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656
Query: 172 QPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIH 231
+ + +H A+++G D+V LLL G N+H+ G+T L +AA+ +V + L
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
Query: 232 KGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLA 291
G D A G + L A GN ++ LL+ G + N + G+ P+H+AA +GH
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776
Query: 292 LKYLIPVTSK-NAIRKSGLTPI 312
+ L+ +K NA +G T +
Sbjct: 777 INVLLQHGAKPNATTANGNTAL 798
Score = 104 bits (260), Expect = 2e-22
Identities = 77/288 (26%), Positives = 135/288 (46%), Gaps = 3/288 (1%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A K G + + ++ + A D A + G PLH A Q++ ++L+ K
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK-- 627
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
+G TPL +A K ++ TLL G N +G TPL +A ++G DMV+ L+ +
Sbjct: 628 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+ +++H AA++ + ++ +L KHG + G TPL VA YG+ ++ L
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ +G +V A +G + L +AA G+ I++LL++G N G+ + A G+
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYI 807
Query: 290 LALKYLIPVTSKNAIRKSGLTPIHSAADGQN-AQCLELLIENGFDVNT 336
+ L VT + + +T H + + L++ E G D T
Sbjct: 808 SVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMT 855
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 146 bits (369), Expect = 5e-35
Identities = 106/369 (28%), Positives = 192/369 (52%), Gaps = 27/369 (7%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A K+GH+ +QE + ++D A +KG LH A + +++++++ ++
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI--NAQSQ 128
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
+G TPL +A + ++ V+ LLE G +T + G TPL +A+++G V+ L++++T
Sbjct: 129 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 188
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGF--------GVTPLGVAAEYG 221
R A+H AA++ ALLL++ N ++ G TPL +AA YG
Sbjct: 189 ----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244
Query: 222 HCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIH 281
+ +V L+++G V A +G + L A+ GN + + LLL+ GG + R G P+H
Sbjct: 245 NVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH 304
Query: 282 RAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
AA GH ++ L+ + R K+GL+P+H AA G + +C++ L+++ V+ + D
Sbjct: 305 CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 364
Query: 341 HISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLVAVRANNYEIVR 397
++ TAL+ T++LL A+PN LN L +A + N +++
Sbjct: 365 YL---------TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVME 415
Query: 398 LLLSHGANV 406
LL+ +GA++
Sbjct: 416 LLVKYGASI 424
Score = 143 bits (360), Expect = 5e-34
Identities = 105/362 (29%), Positives = 173/362 (47%), Gaps = 15/362 (4%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A K+ I ++ VKY ++ E G P+H A I+ ++L +
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP--DVTNI 462
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
GET L +A +AG VE VR LL G + + + +TPL IA + G ++V L++H
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
D ++ +H +A++G+ D+ ++LL+ G L G TPL VAA+YG DV + L
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ + + +G + L AA N LLLE G S + + G+ P+H AA +
Sbjct: 583 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642
Query: 290 LALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDD 348
L+ ++ N + K G+TP+H A+ + + LL++ G ++ H+S
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI------HMSTK--- 693
Query: 349 ERKTALYFGVSNNDVHCTEVLLAAGADPNLDP---LNCLLVAVRANNYEIVRLLLSHGAN 405
T+L+ + V+ ++L GAD + L+VA N ++V LL GAN
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 753
Query: 406 VN 407
VN
Sbjct: 754 VN 755
Score = 115 bits (288), Expect = 1e-25
Identities = 89/309 (28%), Positives = 144/309 (46%), Gaps = 23/309 (7%)
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
K D A +AG ++ V L+ G+ NT N G L +A K+G +V L+
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
+S+D K +A+H A+ G+ ++V +L+K G N++ + G TPL +AA+ H DV+
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE 286
++L+ G + +DG + L A G+ +++LLE G V A H+ + +
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
Query: 287 GHYLALK--YLIPVTSK---NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADH 341
L L+ + V SK N +SG TP+H AA N LL+ G V+ +
Sbjct: 207 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 266
Query: 342 ISQSYDDERKTALYFGVSNNDVHCTEVLLAAGAD------PNLDPLNCLLVAVRANNYEI 395
I T L+ + + ++LL G L PL+C A R+ + ++
Sbjct: 267 I---------TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC---AARSGHDQV 314
Query: 396 VRLLLSHGA 404
V LLL GA
Sbjct: 315 VELLLERGA 323
Score = 108 bits (269), Expect = 2e-23
Identities = 94/315 (29%), Positives = 141/315 (44%), Gaps = 17/315 (5%)
Query: 97 DASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGS 156
D K + T G TPL +A G V LL +G + G TPL +A K+G+
Sbjct: 219 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 278
Query: 157 YDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGV 216
+MV L+ +D + +H AA+ G +V LLL+ G + R G++PL +
Sbjct: 279 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHM 338
Query: 217 AAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAG 276
AA+ H + ++HL+ V + D + L AA G+ LLL+ + N G
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG 398
Query: 277 HLPIHRAAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGF--D 333
P+H A + ++ L+ S AI +SGLTPIH AA + + LL++NG D
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 334 VNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRA 390
V + + TAL+ V LL GA + + L +A R
Sbjct: 459 VTNIRGE-----------TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507
Query: 391 NNYEIVRLLLSHGAN 405
EIV+LLL H A+
Sbjct: 508 GKTEIVQLLLQHMAH 522
Score = 108 bits (269), Expect = 2e-23
Identities = 92/341 (26%), Positives = 156/341 (45%), Gaps = 15/341 (4%)
Query: 68 AMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENV 127
A+D G PLH A + +++++LD + + KT DG TPL A ++G + V
Sbjct: 258 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI--DAKTRDGLTPLHCAARSGHDQVV 315
Query: 128 RTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQ 187
LLE+G + G +PL +A + + V L++H +D + +A+H AA
Sbjct: 316 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375
Query: 188 GRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVL 247
G + LLL N + R G TPL +A + V+E L+ G + A+ + G + +
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
Query: 248 FEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTS-KNAIRK 306
AA G+ + + LLL+ G S +V N G +H AA G ++ L+ + +A +
Sbjct: 436 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR 495
Query: 307 SGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCT 366
TP+H A+ + ++LL+++ + + T L+ V
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY---------TPLHISAREGQVDVA 546
Query: 367 EVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGA 404
VLL AGA +L L VA + + ++ +LLL A
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Score = 106 bits (264), Expect = 7e-23
Identities = 72/292 (24%), Positives = 138/292 (47%), Gaps = 3/292 (1%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + G +Q +++ D A G+ PLH + + + ++L+A T
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG--AAHSLATK 561
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
G TPL +A K G ++ + LL++ ++ G TPL +A + + L++ S
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
++ +H AAK+ + I + LL +G ++ GVTPL +A++ GH D++ L
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ KG ++ G + L AA + +L ++G + + G+ P+ A + G+
Sbjct: 682 LDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 741
Query: 290 LALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
+ +L+ + NA K+G TP+H AA + + +L+++G N A+
Sbjct: 742 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTAN 793
Score = 105 bits (261), Expect = 2e-22
Identities = 75/262 (28%), Positives = 125/262 (47%), Gaps = 3/262 (1%)
Query: 52 KQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDG 111
++G + ++ A A +KG+ PLH A + +++L + + +G
Sbjct: 539 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR--RAAADSAGKNG 596
Query: 112 ETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLD 171
TPL +A + LLEKG P+ G TPL IA KK + STL+ + +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656
Query: 172 QPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIH 231
+ + +H A+++G D+V LLL G N+H+ G+T L +AA+ +V + L
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
Query: 232 KGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLA 291
G D A G + L A GN ++ LL+ G + N + G+ P+H+AA +GH
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776
Query: 292 LKYLIPVTSK-NAIRKSGLTPI 312
+ L+ +K NA +G T +
Sbjct: 777 INVLLQHGAKPNATTANGNTAL 798
Score = 104 bits (260), Expect = 2e-22
Identities = 77/288 (26%), Positives = 135/288 (46%), Gaps = 3/288 (1%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A K G + + ++ + A D A + G PLH A Q++ ++L+ K
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK-- 627
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
+G TPL +A K ++ TLL G N +G TPL +A ++G DMV+ L+ +
Sbjct: 628 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+ +++H AA++ + ++ +L KHG + G TPL VA YG+ ++ L
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ +G +V A +G + L +AA G+ I++LL++G N G+ + A G+
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYI 807
Query: 290 LALKYLIPVTSKNAIRKSGLTPIHSAADGQN-AQCLELLIENGFDVNT 336
+ L VT + + +T H + + L++ E G D T
Sbjct: 808 SVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMT 855
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 143 bits (360), Expect = 5e-34
Identities = 105/362 (29%), Positives = 173/362 (47%), Gaps = 15/362 (4%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A K+ I ++ VKY ++ E G P+H A I+ ++L +
Sbjct: 384 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP--DVTNI 441
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
GET L +A +AG VE VR LL G + + + +TPL IA + G ++V L++H
Sbjct: 442 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 501
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
D ++ +H +A++G+ D+ ++LL+ G L G TPL VAA+YG DV + L
Sbjct: 502 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ + + +G + L AA N LLLE G S + + G+ P+H AA +
Sbjct: 562 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 621
Query: 290 LALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDD 348
L+ ++ N + K G+TP+H A+ + + LL++ G ++ H+S
Sbjct: 622 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI------HMSTK--- 672
Query: 349 ERKTALYFGVSNNDVHCTEVLLAAGADPNLDP---LNCLLVAVRANNYEIVRLLLSHGAN 405
T+L+ + V+ ++L GAD + L+VA N ++V LL GAN
Sbjct: 673 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 732
Query: 406 VN 407
VN
Sbjct: 733 VN 734
Score = 129 bits (325), Expect = 6e-30
Identities = 105/407 (25%), Positives = 189/407 (46%), Gaps = 52/407 (12%)
Query: 41 SAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASY 100
S N + A + G++ ++ EY+K ++ ++ G LH A + +++ +L
Sbjct: 8 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 67
Query: 101 KTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMV 160
+ T G T L +A AG E V+ L+++G N ++ G TPL +A ++ D+V
Sbjct: 68 SV--DSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
Query: 161 STLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHG--GNVHL------------- 205
L+++ + ++ + A +QG VA+LL++ G V L
Sbjct: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
Query: 206 ----------------------RDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDG 243
G TPL +AA YG+ +V L+++G V A +G
Sbjct: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
Query: 244 ASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNA 303
+ L A+ GN + + LLL+ GG + R G P+H AA GH ++ L+ +
Sbjct: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305
Query: 304 IR-KSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNND 362
R K+GL+P+H AA G + +C++ L+++ V+ + D++ TAL+
Sbjct: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL---------TALHVAAHCGH 356
Query: 363 VHCTEVLLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGANV 406
T++LL A+PN LN L +A + N +++ LL+ +GA++
Sbjct: 357 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 403
Score = 108 bits (269), Expect = 2e-23
Identities = 94/315 (29%), Positives = 141/315 (44%), Gaps = 17/315 (5%)
Query: 97 DASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGS 156
D K + T G TPL +A G V LL +G + G TPL +A K+G+
Sbjct: 198 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 257
Query: 157 YDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGV 216
+MV L+ +D + +H AA+ G +V LLL+ G + R G++PL +
Sbjct: 258 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHM 317
Query: 217 AAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAG 276
AA+ H + ++HL+ V + D + L AA G+ LLL+ + N G
Sbjct: 318 AAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG 377
Query: 277 HLPIHRAAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGF--D 333
P+H A + ++ L+ S AI +SGLTPIH AA + + LL++NG D
Sbjct: 378 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 437
Query: 334 VNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRA 390
V + + TAL+ V LL GA + + L +A R
Sbjct: 438 VTNIRGE-----------TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 486
Query: 391 NNYEIVRLLLSHGAN 405
EIV+LLL H A+
Sbjct: 487 GKTEIVQLLLQHMAH 501
Score = 108 bits (269), Expect = 2e-23
Identities = 92/341 (26%), Positives = 156/341 (45%), Gaps = 15/341 (4%)
Query: 68 AMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENV 127
A+D G PLH A + +++++LD + + KT DG TPL A ++G + V
Sbjct: 237 AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI--DAKTRDGLTPLHCAARSGHDQVV 294
Query: 128 RTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQ 187
LLE+G + G +PL +A + + V L++H +D + +A+H AA
Sbjct: 295 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 354
Query: 188 GRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVL 247
G + LLL N + R G TPL +A + V+E L+ G + A+ + G + +
Sbjct: 355 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 414
Query: 248 FEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTS-KNAIRK 306
AA G+ + + LLL+ G S +V N G +H AA G ++ L+ + +A +
Sbjct: 415 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR 474
Query: 307 SGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCT 366
TP+H A+ + ++LL+++ + + T L+ V
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY---------TPLHISAREGQVDVA 525
Query: 367 EVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGA 404
VLL AGA +L L VA + + ++ +LLL A
Sbjct: 526 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 566
Score = 106 bits (264), Expect = 7e-23
Identities = 72/292 (24%), Positives = 138/292 (47%), Gaps = 3/292 (1%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + G +Q +++ D A G+ PLH + + + ++L+A T
Sbjct: 483 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG--AAHSLATK 540
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
G TPL +A K G ++ + LL++ ++ G TPL +A + + L++ S
Sbjct: 541 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 600
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
++ +H AAK+ + I + LL +G ++ GVTPL +A++ GH D++ L
Sbjct: 601 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ KG ++ G + L AA + +L ++G + + G+ P+ A + G+
Sbjct: 661 LDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 720
Query: 290 LALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
+ +L+ + NA K+G TP+H AA + + +L+++G N A+
Sbjct: 721 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTAN 772
Score = 105 bits (261), Expect = 2e-22
Identities = 75/262 (28%), Positives = 125/262 (47%), Gaps = 3/262 (1%)
Query: 52 KQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDG 111
++G + ++ A A +KG+ PLH A + +++L + + +G
Sbjct: 518 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR--RAAADSAGKNG 575
Query: 112 ETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLD 171
TPL +A + LLEKG P+ G TPL IA KK + STL+ + +
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 635
Query: 172 QPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIH 231
+ + +H A+++G D+V LLL G N+H+ G+T L +AA+ +V + L
Sbjct: 636 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 695
Query: 232 KGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLA 291
G D A G + L A GN ++ LL+ G + N + G+ P+H+AA +GH
Sbjct: 696 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 755
Query: 292 LKYLIPVTSK-NAIRKSGLTPI 312
+ L+ +K NA +G T +
Sbjct: 756 INVLLQHGAKPNATTANGNTAL 777
Score = 104 bits (260), Expect = 2e-22
Identities = 77/288 (26%), Positives = 135/288 (46%), Gaps = 3/288 (1%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A K G + + ++ + A D A + G PLH A Q++ ++L+ K
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK-- 606
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
+G TPL +A K ++ TLL G N +G TPL +A ++G DMV+ L+ +
Sbjct: 607 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 666
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+ +++H AA++ + ++ +L KHG + G TPL VA YG+ ++ L
Sbjct: 667 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 726
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ +G +V A +G + L +AA G+ I++LL++G N G+ + A G+
Sbjct: 727 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYI 786
Query: 290 LALKYLIPVTSKNAIRKSGLTPIHSAADGQN-AQCLELLIENGFDVNT 336
+ L VT + + +T H + + L++ E G D T
Sbjct: 787 SVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMT 834
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 139 bits (350), Expect = 7e-33
Identities = 107/362 (29%), Positives = 167/362 (46%), Gaps = 15/362 (4%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + GH+ + + + + + G P+H A + ++L Y + T
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--YDAEIDDITL 369
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
D TPL +A G + LL+KG PN++ G TPL IA KK ++ L+K S
Sbjct: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+D + +H A+ G IV LL+ G + ++ + TPL +AA GH +V ++L
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ V A A D + L AA G+ + + LLLE + N+ AGH P+H AA EGH
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
Query: 290 -LALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDD 348
L L S+ + K G TP+H AA + ELL+E N + +
Sbjct: 550 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL------ 603
Query: 349 ERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGAN 405
T L+ V +N++ ++LL G P+ N L +A + N E+ R LL +G +
Sbjct: 604 ---TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 660
Query: 406 VN 407
N
Sbjct: 661 AN 662
Score = 125 bits (313), Expect = 1e-28
Identities = 107/360 (29%), Positives = 161/360 (44%), Gaps = 30/360 (8%)
Query: 74 EKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEK 133
+ G PLH A + ++ ++LD + E KT D TPL A + G V LL+
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQI--ETKTKDELTPLHCAARNGHVRISEILLDH 327
Query: 134 GVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIV 193
G K G +P+ +A + D V L++++ +D + + +H AA G +
Sbjct: 328 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 387
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
+LL G + R G TPL +A + H V+E L+ G + A+ + G + L A+
Sbjct: 388 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 447
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPI 312
G+ + LL+ G S NV N P+H AA GH KYL+ +K NA K TP+
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 507
Query: 313 HSAADGQNAQCLELLIENGFDVN-----------------------TLLADHISQSYDDE 349
H AA + ++LL+EN + N LL SQ+ +
Sbjct: 508 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 567
Query: 350 RK-TALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGAN 405
+ T L+ V E+LL A PN + L L VAV NN +IV+LLL G +
Sbjct: 568 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 627
Score = 123 bits (309), Expect = 4e-28
Identities = 99/355 (27%), Positives = 159/355 (44%), Gaps = 42/355 (11%)
Query: 54 GHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGET 113
GH+P ++ ++ + + ++ K PLH A ++ + +L K K D +T
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV--NAKAKDDQT 505
Query: 114 PLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQP 173
PL A + G V+ LLE PN G TPL IA ++G + V L++ S
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 565
Query: 174 CVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKG 233
K ++ +H AAK G+ + LLL+ + + G+TPL VA + + D+++ L+ +G
Sbjct: 566 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625
Query: 234 GDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALK 293
G + A +G + L AA + LL+YGGS N + G P+H AA EGH +
Sbjct: 626 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 685
Query: 294 YLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKT 352
L+ + N KSGLTP+H A + ++LI++G
Sbjct: 686 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG--------------------- 724
Query: 353 ALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
V++ A PL+ VA N ++V+ LL H A+VN
Sbjct: 725 ---------------VMVDATTRMGYTPLH---VASHYGNIKLVKFLLQHQADVN 761
Score = 122 bits (305), Expect = 1e-27
Identities = 104/402 (25%), Positives = 186/402 (46%), Gaps = 62/402 (15%)
Query: 48 VEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLH----EAVVQPIQQIL--EIVLDASYK 101
+ A + G++ + ++++ ++ ++ G LH E V+ + ++L EI+L+ + K
Sbjct: 50 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 109
Query: 102 TLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVS 161
G T L +A AG E VR L+ G N ++ KG TPL +A ++ ++V
Sbjct: 110 K--------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 161
Query: 162 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHG--GNVHL-------------- 205
L+++ + + ++ + A +QG +++VA L+ +G G V L
Sbjct: 162 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 221
Query: 206 -------------RDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAG 252
G TPL +AA Y + +V + L+++G V +G + L A+
Sbjct: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281
Query: 253 GGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY----LALKYLIPVTSKNAIRKSG 308
GN + LLL+ G + P+H AA GH + L + P+ +K K+G
Sbjct: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT---KNG 338
Query: 309 LTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEV 368
L+PIH AA G + C+ LL++ +++ + DH+ T L+ +V
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---------TPLHVAAHCGHHRVAKV 389
Query: 369 LLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGANVN 407
LL GA PN LN L +A + N+ ++ LLL GA+++
Sbjct: 390 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
Score = 119 bits (298), Expect = 8e-27
Identities = 93/322 (28%), Positives = 146/322 (45%), Gaps = 10/322 (3%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + GH + ++ K ++ + PLH A +++++L+ + T
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP--NLATT 534
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
G TPL +A + G VE V LLEK KG TPL +A K G + L++ +
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 594
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+ + +H A DIV LLL GG+ H G TPL +AA+ +V L
Sbjct: 595 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ GG A + G + L AA G+ + ++LLL +GN+ N++G P+H A EGH
Sbjct: 655 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 714
Query: 290 LALKYLIP-VTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVN-------TLLADH 341
LI +A + G TP+H A+ N + ++ L+++ DVN + L
Sbjct: 715 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 774
Query: 342 ISQSYDDERKTALYFGVSNNDV 363
Q + D L G S N+V
Sbjct: 775 AQQGHTDIVTLLLKNGASPNEV 796
Score = 119 bits (298), Expect = 8e-27
Identities = 87/296 (29%), Positives = 145/296 (48%), Gaps = 11/296 (3%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLH----EAVVQPIQQILEIVLDASYKTLWE 105
A + GH ++ ++ + A G PLH E V+ + +LE +AS +
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE--KEASQACM-- 565
Query: 106 FKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIK 165
T G TPL +A K G V LLE+ PN G TPL +AV + D+V L+
Sbjct: 566 --TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623
Query: 166 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
S P ++ +H AAKQ + ++ LL++GG+ + GVTPL +AA+ GH ++
Sbjct: 624 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 683
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAY 285
+ L+ K + G + L A G+ +L+++G + R G+ P+H A++
Sbjct: 684 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 743
Query: 286 EGHYLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
G+ +K+L+ + NA K G +P+H AA + + LL++NG N + +D
Sbjct: 744 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 799
Score = 117 bits (293), Expect = 3e-26
Identities = 109/429 (25%), Positives = 184/429 (42%), Gaps = 49/429 (11%)
Query: 44 NRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTL 103
N L A G ++E V Y ++ +KG+ PL+ A + ++++ +L+
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ- 170
Query: 104 WEFKTCDGETPLTLAVKAGLVENV------------------------------RTLLEK 133
T DG TPL +A++ G ENV LL+
Sbjct: 171 -NVATEDGFTPLAVALQQG-HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN 228
Query: 134 GVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIV 193
P+ + G TPL IA + ++ L+ S++ + +H A+++G +V
Sbjct: 229 DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 288
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
LLL G + + +TPL AA GH + E L+ G + A +G S + AA G
Sbjct: 289 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 348
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPI 312
+ DC+ LLL+Y + P+H AA+ GH+ K L+ +K N+ +G TP+
Sbjct: 349 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 408
Query: 313 HSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAA 372
H A + + +ELL++ G ++ + + T L+ + + LL
Sbjct: 409 HIACKKNHVRVMELLLKTGASIDAVTESGL---------TPLHVASFMGHLPIVKNLLQR 459
Query: 373 GADPNLDPLNC---LLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDE 429
GA PN+ + L +A RA + E+ + LL + A VN D + P +
Sbjct: 460 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA---KAKDDQTPLHCAARIGHT 516
Query: 430 VMLRLLLNN 438
M++LLL N
Sbjct: 517 NMVKLLLEN 525
Score = 112 bits (281), Expect = 7e-25
Identities = 92/334 (27%), Positives = 150/334 (44%), Gaps = 42/334 (12%)
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
K D T A ++G ++ L GV NT N G L +A K+G MV L+
Sbjct: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
L+ K +A+H AA G+ ++V L+ +G NV+ + G TPL +AA+ H +V+
Sbjct: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV--------------- 271
+ L+ G + +DG + L A G+ + ++ L+ YG G V
Sbjct: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 220
Query: 272 ---------PN-----RAGHLPIHRAA-YEGHYLALKYLIPVTSKNAIRKSGLTPIHSAA 316
PN + G P+H AA YE +A L S N ++G+TP+H A+
Sbjct: 221 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 280
Query: 317 DGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGAD- 375
N + LL++ G + T D + T L+ N V +E+LL GA
Sbjct: 281 RRGNVIMVRLLLDRGAQIETKTKDEL---------TPLHCAARNGHVRISEILLDHGAPI 331
Query: 376 --PNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
+ L+ + +A + ++ + VRLLL + A ++
Sbjct: 332 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365
Score = 104 bits (259), Expect = 3e-22
Identities = 81/281 (28%), Positives = 134/281 (47%), Gaps = 15/281 (5%)
Query: 26 EASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVV 85
EAS+ + + F PL A K G + + ++ + A + G PLH AV
Sbjct: 559 EASQACMTKKGFTPLHV-------AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 611
Query: 86 QPIQQILEIVLD---ASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKND 142
I++++L + + W +G TPL +A K VE R+LL+ G N ++
Sbjct: 612 HNNLDIVKLLLPRGGSPHSPAW-----NGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 666
Query: 143 KGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGN 202
+G TPL +A ++G +MV+ L+ + + + +H A++G + +L+KHG
Sbjct: 667 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 726
Query: 203 VHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLL 262
V G TPL VA+ YG+ +++ L+ DV A G S L +AA G+ D ++LL
Sbjct: 727 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 786
Query: 263 LEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNA 303
L+ G S N + G P+ A G+ L VT + +
Sbjct: 787 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 827
Score = 97.8 bits (242), Expect = 2e-20
Identities = 80/304 (26%), Positives = 136/304 (44%), Gaps = 19/304 (6%)
Query: 111 GETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSL 170
G TPL +A + + LL +G N G TPL IA ++G+ MV L+ +
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
Query: 171 DQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 230
+ + +H AA+ G I +LL HG + + G++P+ +AA+ H D + L+
Sbjct: 299 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 358
Query: 231 HKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYL 290
++ + D + L AA G+ +LL+ G N G P+H A + H
Sbjct: 359 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 418
Query: 291 ALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDE 349
++ L+ S +A+ +SGLTP+H A+ + ++ L++ G N + +
Sbjct: 419 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV---------SNVK 469
Query: 350 RKTALYFGVSNNDVHCTEVLLA------AGADPNLDPLNCLLVAVRANNYEIVRLLLSHG 403
+T L+ + LL A A + PL+C A R + +V+LLL +
Sbjct: 470 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC---AARIGHTNMVKLLLENN 526
Query: 404 ANVN 407
AN N
Sbjct: 527 ANPN 530
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 139 bits (350), Expect = 7e-33
Identities = 107/362 (29%), Positives = 167/362 (46%), Gaps = 15/362 (4%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + GH+ + + + + + G P+H A + ++L Y + T
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--YDAEIDDITL 336
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
D TPL +A G + LL+KG PN++ G TPL IA KK ++ L+K S
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+D + +H A+ G IV LL+ G + ++ + TPL +AA GH +V ++L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ V A A D + L AA G+ + + LLLE + N+ AGH P+H AA EGH
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 290 -LALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDD 348
L L S+ + K G TP+H AA + ELL+E N + +
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL------ 570
Query: 349 ERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGAN 405
T L+ V +N++ ++LL G P+ N L +A + N E+ R LL +G +
Sbjct: 571 ---TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 406 VN 407
N
Sbjct: 628 AN 629
Score = 125 bits (313), Expect = 1e-28
Identities = 107/360 (29%), Positives = 161/360 (44%), Gaps = 30/360 (8%)
Query: 74 EKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEK 133
+ G PLH A + ++ ++LD + E KT D TPL A + G V LL+
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQI--ETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 134 GVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIV 193
G K G +P+ +A + D V L++++ +D + + +H AA G +
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
+LL G + R G TPL +A + H V+E L+ G + A+ + G + L A+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPI 312
G+ + LL+ G S NV N P+H AA GH KYL+ +K NA K TP+
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 313 HSAADGQNAQCLELLIENGFDVN-----------------------TLLADHISQSYDDE 349
H AA + ++LL+EN + N LL SQ+ +
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 350 RK-TALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGAN 405
+ T L+ V E+LL A PN + L L VAV NN +IV+LLL G +
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Score = 123 bits (309), Expect = 4e-28
Identities = 99/355 (27%), Positives = 159/355 (44%), Gaps = 42/355 (11%)
Query: 54 GHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGET 113
GH+P ++ ++ + + ++ K PLH A ++ + +L K K D +T
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV--NAKAKDDQT 472
Query: 114 PLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQP 173
PL A + G V+ LLE PN G TPL IA ++G + V L++ S
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 174 CVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKG 233
K ++ +H AAK G+ + LLL+ + + G+TPL VA + + D+++ L+ +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 234 GDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALK 293
G + A +G + L AA + LL+YGGS N + G P+H AA EGH +
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 294 YLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKT 352
L+ + N KSGLTP+H A + ++LI++G
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG--------------------- 691
Query: 353 ALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
V++ A PL+ VA N ++V+ LL H A+VN
Sbjct: 692 ---------------VMVDATTRMGYTPLH---VASHYGNIKLVKFLLQHQADVN 728
Score = 122 bits (305), Expect = 1e-27
Identities = 104/402 (25%), Positives = 186/402 (46%), Gaps = 62/402 (15%)
Query: 48 VEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLH----EAVVQPIQQIL--EIVLDASYK 101
+ A + G++ + ++++ ++ ++ G LH E V+ + ++L EI+L+ + K
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 102 TLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVS 161
G T L +A AG E VR L+ G N ++ KG TPL +A ++ ++V
Sbjct: 77 K--------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 162 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHG--GNVHL-------------- 205
L+++ + + ++ + A +QG +++VA L+ +G G V L
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188
Query: 206 -------------RDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAG 252
G TPL +AA Y + +V + L+++G V +G + L A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 253 GGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY----LALKYLIPVTSKNAIRKSG 308
GN + LLL+ G + P+H AA GH + L + P+ +K K+G
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT---KNG 305
Query: 309 LTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEV 368
L+PIH AA G + C+ LL++ +++ + DH+ T L+ +V
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---------TPLHVAAHCGHHRVAKV 356
Query: 369 LLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGANVN 407
LL GA PN LN L +A + N+ ++ LLL GA+++
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Score = 119 bits (298), Expect = 8e-27
Identities = 93/322 (28%), Positives = 146/322 (45%), Gaps = 10/322 (3%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + GH + ++ K ++ + PLH A +++++L+ + T
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP--NLATT 501
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
G TPL +A + G VE V LLEK KG TPL +A K G + L++ +
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+ + +H A DIV LLL GG+ H G TPL +AA+ +V L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ GG A + G + L AA G+ + ++LLL +GN+ N++G P+H A EGH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 290 LALKYLIP-VTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVN-------TLLADH 341
LI +A + G TP+H A+ N + ++ L+++ DVN + L
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 342 ISQSYDDERKTALYFGVSNNDV 363
Q + D L G S N+V
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEV 763
Score = 119 bits (298), Expect = 8e-27
Identities = 87/296 (29%), Positives = 145/296 (48%), Gaps = 11/296 (3%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLH----EAVVQPIQQILEIVLDASYKTLWE 105
A + GH ++ ++ + A G PLH E V+ + +LE +AS +
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE--KEASQACM-- 532
Query: 106 FKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIK 165
T G TPL +A K G V LLE+ PN G TPL +AV + D+V L+
Sbjct: 533 --TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 166 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
S P ++ +H AAKQ + ++ LL++GG+ + GVTPL +AA+ GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAY 285
+ L+ K + G + L A G+ +L+++G + R G+ P+H A++
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 710
Query: 286 EGHYLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
G+ +K+L+ + NA K G +P+H AA + + LL++NG N + +D
Sbjct: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Score = 117 bits (293), Expect = 3e-26
Identities = 109/429 (25%), Positives = 184/429 (42%), Gaps = 49/429 (11%)
Query: 44 NRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTL 103
N L A G ++E V Y ++ +KG+ PL+ A + ++++ +L+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ- 137
Query: 104 WEFKTCDGETPLTLAVKAGLVENV------------------------------RTLLEK 133
T DG TPL +A++ G ENV LL+
Sbjct: 138 -NVATEDGFTPLAVALQQG-HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 134 GVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIV 193
P+ + G TPL IA + ++ L+ S++ + +H A+++G +V
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
LLL G + + +TPL AA GH + E L+ G + A +G S + AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPI 312
+ DC+ LLL+Y + P+H AA+ GH+ K L+ +K N+ +G TP+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Query: 313 HSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAA 372
H A + + +ELL++ G ++ + + T L+ + + LL
Sbjct: 376 HIACKKNHVRVMELLLKTGASIDAVTESGL---------TPLHVASFMGHLPIVKNLLQR 426
Query: 373 GADPNLDPLNC---LLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDE 429
GA PN+ + L +A RA + E+ + LL + A VN D + P +
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA---KAKDDQTPLHCAARIGHT 483
Query: 430 VMLRLLLNN 438
M++LLL N
Sbjct: 484 NMVKLLLEN 492
Score = 114 bits (284), Expect = 3e-25
Identities = 92/335 (27%), Positives = 151/335 (45%), Gaps = 42/335 (12%)
Query: 106 FKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIK 165
F+ D T A ++G ++ L GV NT N G L +A K+G MV L+
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 166 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
L+ K +A+H AA G+ ++V L+ +G NV+ + G TPL +AA+ H +V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV-------------- 271
++ L+ G + +DG + L A G+ + ++ L+ YG G V
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 272 ----------PN-----RAGHLPIHRAA-YEGHYLALKYLIPVTSKNAIRKSGLTPIHSA 315
PN + G P+H AA YE +A L S N ++G+TP+H A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 316 ADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGAD 375
+ N + LL++ G + T D + T L+ N V +E+LL GA
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDEL---------TPLHCAARNGHVRISEILLDHGAP 297
Query: 376 ---PNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
+ L+ + +A + ++ + VRLLL + A ++
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 104 bits (259), Expect = 3e-22
Identities = 81/281 (28%), Positives = 134/281 (47%), Gaps = 15/281 (5%)
Query: 26 EASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVV 85
EAS+ + + F PL A K G + + ++ + A + G PLH AV
Sbjct: 526 EASQACMTKKGFTPLHV-------AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Query: 86 QPIQQILEIVLD---ASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKND 142
I++++L + + W +G TPL +A K VE R+LL+ G N ++
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAW-----NGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
Query: 143 KGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGN 202
+G TPL +A ++G +MV+ L+ + + + +H A++G + +L+KHG
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 203 VHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLL 262
V G TPL VA+ YG+ +++ L+ DV A G S L +AA G+ D ++LL
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 263 LEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNA 303
L+ G S N + G P+ A G+ L VT + +
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Score = 97.8 bits (242), Expect = 2e-20
Identities = 80/304 (26%), Positives = 136/304 (44%), Gaps = 19/304 (6%)
Query: 111 GETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSL 170
G TPL +A + + LL +G N G TPL IA ++G+ MV L+ +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 171 DQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 230
+ + +H AA+ G I +LL HG + + G++P+ +AA+ H D + L+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
Query: 231 HKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYL 290
++ + D + L AA G+ +LL+ G N G P+H A + H
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 291 ALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDE 349
++ L+ S +A+ +SGLTP+H A+ + ++ L++ G N + +
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV---------SNVK 436
Query: 350 RKTALYFGVSNNDVHCTEVLLA------AGADPNLDPLNCLLVAVRANNYEIVRLLLSHG 403
+T L+ + LL A A + PL+C A R + +V+LLL +
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC---AARIGHTNMVKLLLENN 493
Query: 404 ANVN 407
AN N
Sbjct: 494 ANPN 497
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 139 bits (350), Expect = 7e-33
Identities = 107/362 (29%), Positives = 167/362 (46%), Gaps = 15/362 (4%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + GH+ + + + + + G P+H A + ++L Y + T
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--YDAEIDDITL 336
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
D TPL +A G + LL+KG PN++ G TPL IA KK ++ L+K S
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+D + +H A+ G IV LL+ G + ++ + TPL +AA GH +V ++L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ V A A D + L AA G+ + + LLLE + N+ AGH P+H AA EGH
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 290 -LALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDD 348
L L S+ + K G TP+H AA + ELL+E N + +
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL------ 570
Query: 349 ERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGAN 405
T L+ V +N++ ++LL G P+ N L +A + N E+ R LL +G +
Sbjct: 571 ---TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 406 VN 407
N
Sbjct: 628 AN 629
Score = 125 bits (313), Expect = 1e-28
Identities = 107/360 (29%), Positives = 161/360 (44%), Gaps = 30/360 (8%)
Query: 74 EKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEK 133
+ G PLH A + ++ ++LD + E KT D TPL A + G V LL+
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQI--ETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 134 GVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIV 193
G K G +P+ +A + D V L++++ +D + + +H AA G +
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
+LL G + R G TPL +A + H V+E L+ G + A+ + G + L A+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPI 312
G+ + LL+ G S NV N P+H AA GH KYL+ +K NA K TP+
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 313 HSAADGQNAQCLELLIENGFDVN-----------------------TLLADHISQSYDDE 349
H AA + ++LL+EN + N LL SQ+ +
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 350 RK-TALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGAN 405
+ T L+ V E+LL A PN + L L VAV NN +IV+LLL G +
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Score = 123 bits (309), Expect = 4e-28
Identities = 99/355 (27%), Positives = 159/355 (44%), Gaps = 42/355 (11%)
Query: 54 GHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGET 113
GH+P ++ ++ + + ++ K PLH A ++ + +L K K D +T
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV--NAKAKDDQT 472
Query: 114 PLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQP 173
PL A + G V+ LLE PN G TPL IA ++G + V L++ S
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 174 CVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKG 233
K ++ +H AAK G+ + LLL+ + + G+TPL VA + + D+++ L+ +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 234 GDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALK 293
G + A +G + L AA + LL+YGGS N + G P+H AA EGH +
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 294 YLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKT 352
L+ + N KSGLTP+H A + ++LI++G
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG--------------------- 691
Query: 353 ALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
V++ A PL+ VA N ++V+ LL H A+VN
Sbjct: 692 ---------------VMVDATTRMGYTPLH---VASHYGNIKLVKFLLQHQADVN 728
Score = 122 bits (305), Expect = 1e-27
Identities = 104/402 (25%), Positives = 186/402 (46%), Gaps = 62/402 (15%)
Query: 48 VEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLH----EAVVQPIQQIL--EIVLDASYK 101
+ A + G++ + ++++ ++ ++ G LH E V+ + ++L EI+L+ + K
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 102 TLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVS 161
G T L +A AG E VR L+ G N ++ KG TPL +A ++ ++V
Sbjct: 77 K--------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 162 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHG--GNVHL-------------- 205
L+++ + + ++ + A +QG +++VA L+ +G G V L
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188
Query: 206 -------------RDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAG 252
G TPL +AA Y + +V + L+++G V +G + L A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 253 GGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY----LALKYLIPVTSKNAIRKSG 308
GN + LLL+ G + P+H AA GH + L + P+ +K K+G
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT---KNG 305
Query: 309 LTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEV 368
L+PIH AA G + C+ LL++ +++ + DH+ T L+ +V
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---------TPLHVAAHCGHHRVAKV 356
Query: 369 LLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGANVN 407
LL GA PN LN L +A + N+ ++ LLL GA+++
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Score = 119 bits (298), Expect = 8e-27
Identities = 93/322 (28%), Positives = 146/322 (45%), Gaps = 10/322 (3%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + GH + ++ K ++ + PLH A +++++L+ + T
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP--NLATT 501
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
G TPL +A + G VE V LLEK KG TPL +A K G + L++ +
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+ + +H A DIV LLL GG+ H G TPL +AA+ +V L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ GG A + G + L AA G+ + ++LLL +GN+ N++G P+H A EGH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 290 LALKYLIP-VTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVN-------TLLADH 341
LI +A + G TP+H A+ N + ++ L+++ DVN + L
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 342 ISQSYDDERKTALYFGVSNNDV 363
Q + D L G S N+V
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEV 763
Score = 119 bits (298), Expect = 8e-27
Identities = 87/296 (29%), Positives = 145/296 (48%), Gaps = 11/296 (3%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLH----EAVVQPIQQILEIVLDASYKTLWE 105
A + GH ++ ++ + A G PLH E V+ + +LE +AS +
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE--KEASQACM-- 532
Query: 106 FKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIK 165
T G TPL +A K G V LLE+ PN G TPL +AV + D+V L+
Sbjct: 533 --TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 166 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
S P ++ +H AAKQ + ++ LL++GG+ + GVTPL +AA+ GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAY 285
+ L+ K + G + L A G+ +L+++G + R G+ P+H A++
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 710
Query: 286 EGHYLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
G+ +K+L+ + NA K G +P+H AA + + LL++NG N + +D
Sbjct: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Score = 117 bits (293), Expect = 3e-26
Identities = 109/429 (25%), Positives = 184/429 (42%), Gaps = 49/429 (11%)
Query: 44 NRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTL 103
N L A G ++E V Y ++ +KG+ PL+ A + ++++ +L+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ- 137
Query: 104 WEFKTCDGETPLTLAVKAGLVENV------------------------------RTLLEK 133
T DG TPL +A++ G ENV LL+
Sbjct: 138 -NVATEDGFTPLAVALQQG-HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 134 GVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIV 193
P+ + G TPL IA + ++ L+ S++ + +H A+++G +V
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
LLL G + + +TPL AA GH + E L+ G + A +G S + AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPI 312
+ DC+ LLL+Y + P+H AA+ GH+ K L+ +K N+ +G TP+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Query: 313 HSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAA 372
H A + + +ELL++ G ++ + + T L+ + + LL
Sbjct: 376 HIACKKNHVRVMELLLKTGASIDAVTESGL---------TPLHVASFMGHLPIVKNLLQR 426
Query: 373 GADPNLDPLNC---LLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDE 429
GA PN+ + L +A RA + E+ + LL + A VN D + P +
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA---KAKDDQTPLHCAARIGHT 483
Query: 430 VMLRLLLNN 438
M++LLL N
Sbjct: 484 NMVKLLLEN 492
Score = 114 bits (284), Expect = 3e-25
Identities = 92/335 (27%), Positives = 151/335 (45%), Gaps = 42/335 (12%)
Query: 106 FKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIK 165
F+ D T A ++G ++ L GV NT N G L +A K+G MV L+
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 166 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
L+ K +A+H AA G+ ++V L+ +G NV+ + G TPL +AA+ H +V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV-------------- 271
++ L+ G + +DG + L A G+ + ++ L+ YG G V
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 272 ----------PN-----RAGHLPIHRAA-YEGHYLALKYLIPVTSKNAIRKSGLTPIHSA 315
PN + G P+H AA YE +A L S N ++G+TP+H A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 316 ADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGAD 375
+ N + LL++ G + T D + T L+ N V +E+LL GA
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDEL---------TPLHCAARNGHVRISEILLDHGAP 297
Query: 376 ---PNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
+ L+ + +A + ++ + VRLLL + A ++
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 104 bits (259), Expect = 3e-22
Identities = 81/281 (28%), Positives = 134/281 (47%), Gaps = 15/281 (5%)
Query: 26 EASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVV 85
EAS+ + + F PL A K G + + ++ + A + G PLH AV
Sbjct: 526 EASQACMTKKGFTPLHV-------AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Query: 86 QPIQQILEIVLD---ASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKND 142
I++++L + + W +G TPL +A K VE R+LL+ G N ++
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAW-----NGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
Query: 143 KGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGN 202
+G TPL +A ++G +MV+ L+ + + + +H A++G + +L+KHG
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 203 VHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLL 262
V G TPL VA+ YG+ +++ L+ DV A G S L +AA G+ D ++LL
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 263 LEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNA 303
L+ G S N + G P+ A G+ L VT + +
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Score = 97.8 bits (242), Expect = 2e-20
Identities = 80/304 (26%), Positives = 136/304 (44%), Gaps = 19/304 (6%)
Query: 111 GETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSL 170
G TPL +A + + LL +G N G TPL IA ++G+ MV L+ +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 171 DQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 230
+ + +H AA+ G I +LL HG + + G++P+ +AA+ H D + L+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
Query: 231 HKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYL 290
++ + D + L AA G+ +LL+ G N G P+H A + H
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 291 ALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDE 349
++ L+ S +A+ +SGLTP+H A+ + ++ L++ G N + +
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV---------SNVK 436
Query: 350 RKTALYFGVSNNDVHCTEVLLA------AGADPNLDPLNCLLVAVRANNYEIVRLLLSHG 403
+T L+ + LL A A + PL+C A R + +V+LLL +
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC---AARIGHTNMVKLLLENN 493
Query: 404 ANVN 407
AN N
Sbjct: 494 ANPN 497
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 139 bits (350), Expect = 7e-33
Identities = 107/362 (29%), Positives = 167/362 (46%), Gaps = 15/362 (4%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + GH+ + + + + + G P+H A + ++L Y + T
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--YDAEIDDITL 336
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
D TPL +A G + LL+KG PN++ G TPL IA KK ++ L+K S
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+D + +H A+ G IV LL+ G + ++ + TPL +AA GH +V ++L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ V A A D + L AA G+ + + LLLE + N+ AGH P+H AA EGH
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 290 -LALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDD 348
L L S+ + K G TP+H AA + ELL+E N + +
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL------ 570
Query: 349 ERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGAN 405
T L+ V +N++ ++LL G P+ N L +A + N E+ R LL +G +
Sbjct: 571 ---TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 406 VN 407
N
Sbjct: 628 AN 629
Score = 125 bits (313), Expect = 1e-28
Identities = 107/360 (29%), Positives = 161/360 (44%), Gaps = 30/360 (8%)
Query: 74 EKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEK 133
+ G PLH A + ++ ++LD + E KT D TPL A + G V LL+
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQI--ETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 134 GVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIV 193
G K G +P+ +A + D V L++++ +D + + +H AA G +
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
+LL G + R G TPL +A + H V+E L+ G + A+ + G + L A+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPI 312
G+ + LL+ G S NV N P+H AA GH KYL+ +K NA K TP+
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 313 HSAADGQNAQCLELLIENGFDVN-----------------------TLLADHISQSYDDE 349
H AA + ++LL+EN + N LL SQ+ +
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 350 RK-TALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGAN 405
+ T L+ V E+LL A PN + L L VAV NN +IV+LLL G +
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Score = 123 bits (309), Expect = 4e-28
Identities = 99/355 (27%), Positives = 159/355 (44%), Gaps = 42/355 (11%)
Query: 54 GHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGET 113
GH+P ++ ++ + + ++ K PLH A ++ + +L K K D +T
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV--NAKAKDDQT 472
Query: 114 PLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQP 173
PL A + G V+ LLE PN G TPL IA ++G + V L++ S
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 174 CVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKG 233
K ++ +H AAK G+ + LLL+ + + G+TPL VA + + D+++ L+ +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 234 GDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALK 293
G + A +G + L AA + LL+YGGS N + G P+H AA EGH +
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 294 YLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKT 352
L+ + N KSGLTP+H A + ++LI++G
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG--------------------- 691
Query: 353 ALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
V++ A PL+ VA N ++V+ LL H A+VN
Sbjct: 692 ---------------VMVDATTRMGYTPLH---VASHYGNIKLVKFLLQHQADVN 728
Score = 122 bits (305), Expect = 1e-27
Identities = 104/402 (25%), Positives = 186/402 (46%), Gaps = 62/402 (15%)
Query: 48 VEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLH----EAVVQPIQQIL--EIVLDASYK 101
+ A + G++ + ++++ ++ ++ G LH E V+ + ++L EI+L+ + K
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 102 TLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVS 161
G T L +A AG E VR L+ G N ++ KG TPL +A ++ ++V
Sbjct: 77 K--------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 162 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHG--GNVHL-------------- 205
L+++ + + ++ + A +QG +++VA L+ +G G V L
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188
Query: 206 -------------RDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAG 252
G TPL +AA Y + +V + L+++G V +G + L A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 253 GGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY----LALKYLIPVTSKNAIRKSG 308
GN + LLL+ G + P+H AA GH + L + P+ +K K+G
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT---KNG 305
Query: 309 LTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEV 368
L+PIH AA G + C+ LL++ +++ + DH+ T L+ +V
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---------TPLHVAAHCGHHRVAKV 356
Query: 369 LLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGANVN 407
LL GA PN LN L +A + N+ ++ LLL GA+++
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Score = 119 bits (298), Expect = 8e-27
Identities = 93/322 (28%), Positives = 146/322 (45%), Gaps = 10/322 (3%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + GH + ++ K ++ + PLH A +++++L+ + T
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP--NLATT 501
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
G TPL +A + G VE V LLEK KG TPL +A K G + L++ +
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+ + +H A DIV LLL GG+ H G TPL +AA+ +V L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ GG A + G + L AA G+ + ++LLL +GN+ N++G P+H A EGH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 290 LALKYLIP-VTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVN-------TLLADH 341
LI +A + G TP+H A+ N + ++ L+++ DVN + L
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 342 ISQSYDDERKTALYFGVSNNDV 363
Q + D L G S N+V
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEV 763
Score = 119 bits (298), Expect = 8e-27
Identities = 87/296 (29%), Positives = 145/296 (48%), Gaps = 11/296 (3%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLH----EAVVQPIQQILEIVLDASYKTLWE 105
A + GH ++ ++ + A G PLH E V+ + +LE +AS +
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE--KEASQACM-- 532
Query: 106 FKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIK 165
T G TPL +A K G V LLE+ PN G TPL +AV + D+V L+
Sbjct: 533 --TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 166 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
S P ++ +H AAKQ + ++ LL++GG+ + GVTPL +AA+ GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAY 285
+ L+ K + G + L A G+ +L+++G + R G+ P+H A++
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 710
Query: 286 EGHYLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
G+ +K+L+ + NA K G +P+H AA + + LL++NG N + +D
Sbjct: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Score = 117 bits (293), Expect = 3e-26
Identities = 109/429 (25%), Positives = 184/429 (42%), Gaps = 49/429 (11%)
Query: 44 NRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTL 103
N L A G ++E V Y ++ +KG+ PL+ A + ++++ +L+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ- 137
Query: 104 WEFKTCDGETPLTLAVKAGLVENV------------------------------RTLLEK 133
T DG TPL +A++ G ENV LL+
Sbjct: 138 -NVATEDGFTPLAVALQQG-HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 134 GVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIV 193
P+ + G TPL IA + ++ L+ S++ + +H A+++G +V
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
LLL G + + +TPL AA GH + E L+ G + A +G S + AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPI 312
+ DC+ LLL+Y + P+H AA+ GH+ K L+ +K N+ +G TP+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Query: 313 HSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAA 372
H A + + +ELL++ G ++ + + T L+ + + LL
Sbjct: 376 HIACKKNHVRVMELLLKTGASIDAVTESGL---------TPLHVASFMGHLPIVKNLLQR 426
Query: 373 GADPNLDPLNC---LLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDE 429
GA PN+ + L +A RA + E+ + LL + A VN D + P +
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA---KAKDDQTPLHCAARIGHT 483
Query: 430 VMLRLLLNN 438
M++LLL N
Sbjct: 484 NMVKLLLEN 492
Score = 114 bits (284), Expect = 3e-25
Identities = 92/335 (27%), Positives = 151/335 (45%), Gaps = 42/335 (12%)
Query: 106 FKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIK 165
F+ D T A ++G ++ L GV NT N G L +A K+G MV L+
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 166 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
L+ K +A+H AA G+ ++V L+ +G NV+ + G TPL +AA+ H +V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV-------------- 271
++ L+ G + +DG + L A G+ + ++ L+ YG G V
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 272 ----------PN-----RAGHLPIHRAA-YEGHYLALKYLIPVTSKNAIRKSGLTPIHSA 315
PN + G P+H AA YE +A L S N ++G+TP+H A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 316 ADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGAD 375
+ N + LL++ G + T D + T L+ N V +E+LL GA
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDEL---------TPLHCAARNGHVRISEILLDHGAP 297
Query: 376 ---PNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
+ L+ + +A + ++ + VRLLL + A ++
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 104 bits (259), Expect = 3e-22
Identities = 81/281 (28%), Positives = 134/281 (47%), Gaps = 15/281 (5%)
Query: 26 EASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVV 85
EAS+ + + F PL A K G + + ++ + A + G PLH AV
Sbjct: 526 EASQACMTKKGFTPLHV-------AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Query: 86 QPIQQILEIVLD---ASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKND 142
I++++L + + W +G TPL +A K VE R+LL+ G N ++
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAW-----NGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
Query: 143 KGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGN 202
+G TPL +A ++G +MV+ L+ + + + +H A++G + +L+KHG
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 203 VHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLL 262
V G TPL VA+ YG+ +++ L+ DV A G S L +AA G+ D ++LL
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 263 LEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNA 303
L+ G S N + G P+ A G+ L VT + +
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Score = 97.8 bits (242), Expect = 2e-20
Identities = 80/304 (26%), Positives = 136/304 (44%), Gaps = 19/304 (6%)
Query: 111 GETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSL 170
G TPL +A + + LL +G N G TPL IA ++G+ MV L+ +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 171 DQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 230
+ + +H AA+ G I +LL HG + + G++P+ +AA+ H D + L+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
Query: 231 HKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYL 290
++ + D + L AA G+ +LL+ G N G P+H A + H
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 291 ALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDE 349
++ L+ S +A+ +SGLTP+H A+ + ++ L++ G N + +
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV---------SNVK 436
Query: 350 RKTALYFGVSNNDVHCTEVLLA------AGADPNLDPLNCLLVAVRANNYEIVRLLLSHG 403
+T L+ + LL A A + PL+C A R + +V+LLL +
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC---AARIGHTNMVKLLLENN 493
Query: 404 ANVN 407
AN N
Sbjct: 494 ANPN 497
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 139 bits (350), Expect = 7e-33
Identities = 107/362 (29%), Positives = 167/362 (46%), Gaps = 15/362 (4%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + GH+ + + + + + G P+H A + ++L Y + T
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--YDAEIDDITL 336
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
D TPL +A G + LL+KG PN++ G TPL IA KK ++ L+K S
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+D + +H A+ G IV LL+ G + ++ + TPL +AA GH +V ++L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ V A A D + L AA G+ + + LLLE + N+ AGH P+H AA EGH
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 290 -LALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDD 348
L L S+ + K G TP+H AA + ELL+E N + +
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL------ 570
Query: 349 ERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGAN 405
T L+ V +N++ ++LL G P+ N L +A + N E+ R LL +G +
Sbjct: 571 ---TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 406 VN 407
N
Sbjct: 628 AN 629
Score = 125 bits (313), Expect = 1e-28
Identities = 107/360 (29%), Positives = 161/360 (44%), Gaps = 30/360 (8%)
Query: 74 EKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEK 133
+ G PLH A + ++ ++LD + E KT D TPL A + G V LL+
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQI--ETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 134 GVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIV 193
G K G +P+ +A + D V L++++ +D + + +H AA G +
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
+LL G + R G TPL +A + H V+E L+ G + A+ + G + L A+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPI 312
G+ + LL+ G S NV N P+H AA GH KYL+ +K NA K TP+
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 313 HSAADGQNAQCLELLIENGFDVN-----------------------TLLADHISQSYDDE 349
H AA + ++LL+EN + N LL SQ+ +
Sbjct: 475 HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTK 534
Query: 350 RK-TALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGAN 405
+ T L+ V E+LL A PN + L L VAV NN +IV+LLL G +
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Score = 123 bits (309), Expect = 4e-28
Identities = 99/355 (27%), Positives = 159/355 (44%), Gaps = 42/355 (11%)
Query: 54 GHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGET 113
GH+P ++ ++ + + ++ K PLH A ++ + +L K K D +T
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV--NAKAKDDQT 472
Query: 114 PLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQP 173
PL A + G V+ LLE PN G TPL IA ++G + V L++ S
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 174 CVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKG 233
K ++ +H AAK G+ + LLL+ + + G+TPL VA + + D+++ L+ +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 234 GDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALK 293
G + A +G + L AA + LL+YGGS N + G P+H AA EGH +
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 294 YLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKT 352
L+ + N KSGLTP+H A + ++LI++G
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG--------------------- 691
Query: 353 ALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
V++ A PL+ VA N ++V+ LL H A+VN
Sbjct: 692 ---------------VMVDATTRMGYTPLH---VASHYGNIKLVKFLLQHQADVN 728
Score = 122 bits (305), Expect = 1e-27
Identities = 104/402 (25%), Positives = 186/402 (46%), Gaps = 62/402 (15%)
Query: 48 VEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLH----EAVVQPIQQIL--EIVLDASYK 101
+ A + G++ + ++++ ++ ++ G LH E V+ + ++L EI+L+ + K
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 102 TLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVS 161
G T L +A AG E VR L+ G N ++ KG TPL +A ++ ++V
Sbjct: 77 K--------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 162 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHG--GNVHL-------------- 205
L+++ + + ++ + A +QG +++VA L+ +G G V L
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188
Query: 206 -------------RDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAG 252
G TPL +AA Y + +V + L+++G V +G + L A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 253 GGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY----LALKYLIPVTSKNAIRKSG 308
GN + LLL+ G + P+H AA GH + L + P+ +K K+G
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT---KNG 305
Query: 309 LTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEV 368
L+PIH AA G + C+ LL++ +++ + DH+ T L+ +V
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---------TPLHVAAHCGHHRVAKV 356
Query: 369 LLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLSHGANVN 407
LL GA PN LN L +A + N+ ++ LLL GA+++
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Score = 119 bits (298), Expect = 8e-27
Identities = 93/322 (28%), Positives = 146/322 (45%), Gaps = 10/322 (3%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A + GH + ++ K ++ + PLH A +++++L+ + T
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP--NLATT 501
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
G TPL +A + G VE V LLEK KG TPL +A K G + L++ +
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+ + +H A DIV LLL GG+ H G TPL +AA+ +V L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY 289
+ GG A + G + L AA G+ + ++LLL +GN+ N++G P+H A EGH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 290 LALKYLIP-VTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVN-------TLLADH 341
LI +A + G TP+H A+ N + ++ L+++ DVN + L
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 342 ISQSYDDERKTALYFGVSNNDV 363
Q + D L G S N+V
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEV 763
Score = 119 bits (298), Expect = 8e-27
Identities = 87/296 (29%), Positives = 145/296 (48%), Gaps = 11/296 (3%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLH----EAVVQPIQQILEIVLDASYKTLWE 105
A + GH ++ ++ + A G PLH E V+ + +LE +AS +
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE--KEASQACM-- 532
Query: 106 FKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIK 165
T G TPL +A K G V LLE+ PN G TPL +AV + D+V L+
Sbjct: 533 --TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 166 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
S P ++ +H AAKQ + ++ LL++GG+ + GVTPL +AA+ GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAY 285
+ L+ K + G + L A G+ +L+++G + R G+ P+H A++
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH 710
Query: 286 EGHYLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
G+ +K+L+ + NA K G +P+H AA + + LL++NG N + +D
Sbjct: 711 YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766
Score = 117 bits (293), Expect = 3e-26
Identities = 109/429 (25%), Positives = 184/429 (42%), Gaps = 49/429 (11%)
Query: 44 NRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTL 103
N L A G ++E V Y ++ +KG+ PL+ A + ++++ +L+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ- 137
Query: 104 WEFKTCDGETPLTLAVKAGLVENV------------------------------RTLLEK 133
T DG TPL +A++ G ENV LL+
Sbjct: 138 -NVATEDGFTPLAVALQQG-HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195
Query: 134 GVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIV 193
P+ + G TPL IA + ++ L+ S++ + +H A+++G +V
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
LLL G + + +TPL AA GH + E L+ G + A +G S + AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPI 312
+ DC+ LLL+Y + P+H AA+ GH+ K L+ +K N+ +G TP+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Query: 313 HSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAA 372
H A + + +ELL++ G ++ + + T L+ + + LL
Sbjct: 376 HIACKKNHVRVMELLLKTGASIDAVTESGL---------TPLHVASFMGHLPIVKNLLQR 426
Query: 373 GADPNLDPLNC---LLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDE 429
GA PN+ + L +A RA + E+ + LL + A VN D + P +
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA---KAKDDQTPLHCAARIGHT 483
Query: 430 VMLRLLLNN 438
M++LLL N
Sbjct: 484 NMVKLLLEN 492
Score = 114 bits (284), Expect = 3e-25
Identities = 92/335 (27%), Positives = 151/335 (45%), Gaps = 42/335 (12%)
Query: 106 FKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIK 165
F+ D T A ++G ++ L GV NT N G L +A K+G MV L+
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 166 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
L+ K +A+H AA G+ ++V L+ +G NV+ + G TPL +AA+ H +V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV-------------- 271
++ L+ G + +DG + L A G+ + ++ L+ YG G V
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 272 ----------PN-----RAGHLPIHRAA-YEGHYLALKYLIPVTSKNAIRKSGLTPIHSA 315
PN + G P+H AA YE +A L S N ++G+TP+H A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 316 ADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGAD 375
+ N + LL++ G + T D + T L+ N V +E+LL GA
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDEL---------TPLHCAARNGHVRISEILLDHGAP 297
Query: 376 ---PNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
+ L+ + +A + ++ + VRLLL + A ++
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 104 bits (259), Expect = 3e-22
Identities = 81/281 (28%), Positives = 134/281 (47%), Gaps = 15/281 (5%)
Query: 26 EASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVV 85
EAS+ + + F PL A K G + + ++ + A + G PLH AV
Sbjct: 526 EASQACMTKKGFTPLHV-------AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Query: 86 QPIQQILEIVLD---ASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKND 142
I++++L + + W +G TPL +A K VE R+LL+ G N ++
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAW-----NGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
Query: 143 KGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGN 202
+G TPL +A ++G +MV+ L+ + + + +H A++G + +L+KHG
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693
Query: 203 VHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLL 262
V G TPL VA+ YG+ +++ L+ DV A G S L +AA G+ D ++LL
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 263 LEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNA 303
L+ G S N + G P+ A G+ L VT + +
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Score = 97.8 bits (242), Expect = 2e-20
Identities = 80/304 (26%), Positives = 136/304 (44%), Gaps = 19/304 (6%)
Query: 111 GETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSL 170
G TPL +A + + LL +G N G TPL IA ++G+ MV L+ +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 171 DQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 230
+ + +H AA+ G I +LL HG + + G++P+ +AA+ H D + L+
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
Query: 231 HKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYL 290
++ + D + L AA G+ +LL+ G N G P+H A + H
Sbjct: 326 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 291 ALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDE 349
++ L+ S +A+ +SGLTP+H A+ + ++ L++ G N + +
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV---------SNVK 436
Query: 350 RKTALYFGVSNNDVHCTEVLLA------AGADPNLDPLNCLLVAVRANNYEIVRLLLSHG 403
+T L+ + LL A A + PL+C A R + +V+LLL +
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC---AARIGHTNMVKLLLENN 493
Query: 404 ANVN 407
AN N
Sbjct: 494 ANPN 497
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 130 bits (327), Expect = 3e-30
Identities = 106/350 (30%), Positives = 163/350 (46%), Gaps = 26/350 (7%)
Query: 73 DEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLE 132
D +G+ +H A +Q LE++L+ S+ L + ++ +PL LA G E ++TL E
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606
Query: 133 KGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS-LDQPCVKRWSAMHEAAKQGRKD 191
V + ++ KG T L +A ++GS + V L H S L + ++W+ +H AA G D
Sbjct: 607 TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTD 666
Query: 192 IVALLLKHGGNVHL---RDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLF 248
+ LL+ G + D +G TPL +A GH D + L+ KG A G + L
Sbjct: 667 SLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALH 726
Query: 249 EAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKN-----A 303
A G DC++ LL++ + G PIH A+ GH L+ L+
Sbjct: 727 RGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAG 786
Query: 304 IRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSY-DDERKTALYFGVSNND 362
+ SG +P+H A+ + CLELL+E H SY + T L+ V NN
Sbjct: 787 VDYSGYSPMHWASYTGHEDCLELLLE-----------HSPFSYLEGNPFTPLHCAVINNQ 835
Query: 363 VHCTEVLLAAGADPNLDPLNC-----LLVAVRANNYEIVRLLLSHGANVN 407
TE+LL A ++ + L A A+N +R+LL H A VN
Sbjct: 836 DSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885
Score = 107 bits (267), Expect = 3e-23
Identities = 108/408 (26%), Positives = 177/408 (43%), Gaps = 39/408 (9%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYK----- 101
LV+AI + E++ + K ++ D++ PLH A IL+++L +
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71
Query: 102 TLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVS 161
TLW TPL A + + + LL N ++ +TPL +A +
Sbjct: 72 TLWL-------TPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAE 124
Query: 162 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYG 221
L +SL+ SA+H A G + V LLL G ++++ D PL AA G
Sbjct: 125 ALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLG 184
Query: 222 HCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIH 281
H +VL+ L+ +G D+ G +L AA G + + LL G + PN G+ +H
Sbjct: 185 HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244
Query: 282 RAAYEGH-YLALKYLIPVTSKNAIRKSGLTPIHSAADGQN-AQCLELLIENGFDVNTLLA 339
A Y G +A++ + + N G TP+H AA N A CLELL+ NG DVN
Sbjct: 245 IACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVN---- 300
Query: 340 DHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNC--------LLVAVRAN 391
E K+ L+ + +++L+ G++ ++C L VA R
Sbjct: 301 -----YQSKEGKSPLHMAAIHGRFTRSQILIQNGSE-----IDCADKFGNTPLHVAARYG 350
Query: 392 NYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNG 439
+ ++ L+++GA+ +H FP + R LL++G
Sbjct: 351 HELLISTLMTNGADTARRGIH---DMFPLHLAVLFGFSDCCRKLLSSG 395
Score = 102 bits (255), Expect = 8e-22
Identities = 102/400 (25%), Positives = 166/400 (41%), Gaps = 47/400 (11%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A GH L+ + +D D KG L A + + +E++ L + +
Sbjct: 592 AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPN---TKNDKGETPLLIAVKKGSYDMVSTLIKH 166
TPL A +G +++ L++ G + + G+TPL++A+ G D V L++
Sbjct: 652 KW-TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
++ D ++ +A+H A G +D +A LL H V RD G TP+ +A+ GH VL
Sbjct: 711 GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVL 770
Query: 227 EHLIHK--GGDVLALADD--GASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHR 282
L+ D L D G S + A+ G+ DC+ LLLE+ + P+H
Sbjct: 771 RTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNP-FTPLHC 829
Query: 283 AAYEGHYLALKYLIPVTSKNAIRK---SGLTPIHSAADGQNAQCLELLIENGFDVNTLLA 339
A + L+ + G TP+H+AA N L +L+++ +VN
Sbjct: 830 AVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNA--T 887
Query: 340 DHISQS---------------------------YDDERKTALYFGVSNNDVHCTEVLLAA 372
DH ++ D+ + TAL+ S C ++LA
Sbjct: 888 DHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAE 947
Query: 373 GADPNL-DPLNCLL-----VAVRANNYEIVRLLLSHGANV 406
D L + N L +A R +V+ LLSHGA V
Sbjct: 948 TQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
Score = 91.7 bits (226), Expect = 2e-18
Identities = 96/378 (25%), Positives = 139/378 (36%), Gaps = 69/378 (18%)
Query: 54 GHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGET 113
GH+ L+ V + D KG+ LH A ++++ +L + + G T
Sbjct: 184 GHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEI--DEPNAFGNT 241
Query: 114 PLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIA-VKKGSYDMVSTLIKHNTSLDQ 172
L +A G L+ G N NDKG TPL +A V + L+ + ++
Sbjct: 242 ALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
Query: 173 PCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGH---------- 222
+ S +H AA GR +L+++G + D FG TPL VAA YGH
Sbjct: 302 QSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTN 361
Query: 223 --------------------------CDVL---------------EHLIHKGGDVLALAD 241
C L EH++ G D+ +
Sbjct: 362 GADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDN 421
Query: 242 DGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPV-TS 300
G + L AA GGN +C++LLL G ++ G P+H AA G Y L+
Sbjct: 422 LGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAG 481
Query: 301 KNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSN 360
N G +P+H AA + E H S+D E L
Sbjct: 482 VNEADCKGCSPLHYAAASDTYRRAE--------------PHTPSSHDAEEDEPLKESRRK 527
Query: 361 NDVHCTEVLLAAGADPNL 378
C E LL GADP+L
Sbjct: 528 EAFFCLEFLLDNGADPSL 545
Score = 90.5 bits (223), Expect = 4e-18
Identities = 90/357 (25%), Positives = 154/357 (43%), Gaps = 32/357 (8%)
Query: 112 ETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLD 171
+ PL A+ + VE VR+LL + N + + TPL A G ++ L+ +++
Sbjct: 9 QPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN 68
Query: 172 QPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIH 231
+ +H AA + ++ LLL H +V+ RD TPL VAA E L
Sbjct: 69 AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
Query: 232 KGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLA 291
+ G S L A G+ + ++LLL G S NV ++ P+H AA+ GH
Sbjct: 129 LLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEV 188
Query: 292 LKYLIPVTSKNAIR-KSGLTPIHSAADGQNAQCLELLIENGFDV-------NTLL--ADH 341
LK L+ + + + G +H+AA + ++ L+ G ++ NT L A +
Sbjct: 189 LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACY 248
Query: 342 ISQSY---------------DDERKTALYF-GVSNNDVHCTEVLLAAGADPNL---DPLN 382
+ Q +D+ T L+ VS N C E+L+ GAD N + +
Sbjct: 249 LGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKS 308
Query: 383 CLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNG 439
L +A + ++L+ +G+ ++C N P + E+++ L+ NG
Sbjct: 309 PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNT---PLHVAARYGHELLISTLMTNG 362
Score = 84.0 bits (206), Expect = 4e-16
Identities = 84/304 (27%), Positives = 129/304 (42%), Gaps = 19/304 (6%)
Query: 145 ETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVH 204
+ PL+ A+ + V +L+ +++ +R + +H AA G I+ LLL G NV+
Sbjct: 9 QPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN 68
Query: 205 LRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLE 264
+D +TPL AA + VL L+ DV A + L AA C L
Sbjct: 69 AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
Query: 265 YGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI-PVTSKNAIRKSGLTPIHSAADGQNAQC 323
S NV +R+G +H A + GH + L+ S N K P+H AA + +
Sbjct: 129 LLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEV 188
Query: 324 LELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGA---DPNLDP 380
L+LL+ G D+ D + L+ ++ + + LL GA +PN
Sbjct: 189 LKLLVARGADLG---------CKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
Query: 381 LNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFP--SVIQYALNDEVMLRLLLNN 438
L +A + L++ GANVN ND F V + N + L LL+NN
Sbjct: 240 NTALHIACYLGQDAVAIELVNAGANVN----QPNDKGFTPLHVAAVSTNGALCLELLVNN 295
Query: 439 GYQV 442
G V
Sbjct: 296 GADV 299
Score = 72.4 bits (176), Expect = 1e-12
Identities = 98/382 (25%), Positives = 146/382 (38%), Gaps = 57/382 (14%)
Query: 78 FPLHEAVVQPIQ----------QILEIVLDASYKTL----WEFKTCD--GETPLTLAVKA 121
FPLH AV+ Q+ IV S + + ++ T D G T L A
Sbjct: 374 FPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASG 433
Query: 122 GLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAM 181
G VE + LL G ++ G TPL A GSY TL+ +++ K S +
Sbjct: 434 GNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPL 493
Query: 182 HEAA------------------------KQGRKD----IVALLLKHGGNVHLRDGFGVTP 213
H AA K+ R+ + LL +G + LRD G T
Sbjct: 494 HYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTA 553
Query: 214 LGVAAEYGHCDVLEHLIHKGGDVLALADD--GASVLFEAAGGGNPDCISLLLEYGGSGNV 271
+ AA YG+ LE L+ + L + S L AA G+ + + L E + +V
Sbjct: 554 VHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDV 613
Query: 272 PNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAI--RKSGLTPIHSAADGQNAQCLELLIE 329
+ G + A G ++ L + I RK TP+H+AA + L LLI+
Sbjct: 614 RDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLID 673
Query: 330 NGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPL---NCLLV 386
+G + I+ D +T L + N V C +LL G+ + L L
Sbjct: 674 SGERAD------ITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHR 727
Query: 387 AVRANNYEIVRLLLSHGANVNC 408
+ + LL H A V C
Sbjct: 728 GAVTGCEDCLAALLDHDAFVLC 749
Score = 65.1 bits (157), Expect = 2e-10
Identities = 79/327 (24%), Positives = 135/327 (41%), Gaps = 48/327 (14%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLD-ASYKTLWE 105
L+ AI GH+ + ++ D AD +G LH V + L +LD ++ +
Sbjct: 692 LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRD 751
Query: 106 FKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKND----KGETPLLIAVKKGSYDMVS 161
FK G TP+ LA G +RTLL+ + + + G +P+ A G D +
Sbjct: 752 FK---GRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 808
Query: 162 TLIKHN----------------------------------TSLDQPCVKRWSAMHEAAKQ 187
L++H+ ++ K + +H AA
Sbjct: 809 LLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFA 868
Query: 188 GRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKG-GDVLALADDGASV 246
+ +LL+H V+ D G T L AAE G +E L+++G D+ L ++ +
Sbjct: 869 DNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTA 928
Query: 247 LFEAAGGGNPDCISLLL---EYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIP-VTSKN 302
L A G+ C ++L + G N N A +P+H AA G ++ L+ +
Sbjct: 929 LHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVL 988
Query: 303 AIRKSGLTPIHSAADGQN-AQCLELLI 328
A+ + G TP + A ++ A CL L++
Sbjct: 989 AVDEEGHTPALACAPNKDVADCLALIL 1015
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 127 bits (320), Expect = 2e-29
Identities = 110/406 (27%), Positives = 178/406 (43%), Gaps = 23/406 (5%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L A +QGH + + ++ D+ GW L A +++ +L A K +
Sbjct: 582 LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV--DC 639
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
D T L A G + V LL+ G N +++G T L+ A G ++V L+ H
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH 699
Query: 167 NTSLDQPCVKRWSAMHEAA-----KQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYG 221
++ V +A+ AA +G +V+LL+ G V D G+TPL VAA G
Sbjct: 700 GAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEG 759
Query: 222 HCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIH 281
H DV++ L+ G DV ++G + L AA G+ ++ LL +G + + + G +
Sbjct: 760 HVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLS 819
Query: 282 RAAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
A+ +G+ ++ L+ +N +G TP+H AA + E LIE G N +
Sbjct: 820 IASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEI--- 876
Query: 341 HISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPN---LDPLNCLLVAVRANNYEIVR 397
D++ + C ++LL ++ + D N L VA + +IV
Sbjct: 877 ------DNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930
Query: 398 LLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVE 443
LL SHGA+VNC T + ++ N M L NG VE
Sbjct: 931 LLFSHGADVNCKDADGRPTLYILALE---NQLTMAEYFLENGANVE 973
Score = 108 bits (269), Expect = 2e-23
Identities = 93/307 (30%), Positives = 143/307 (46%), Gaps = 23/307 (7%)
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
DG TPL +A G V+ V LLE G + ++ G TPLL A G +V+TL+ +
Sbjct: 747 DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 806
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
+D + + + A+ QG ++V LL G + + RD G TPL +AA GH + E L
Sbjct: 807 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRA--GHLPIHRAAYEG 287
I +G + +DG A+ G+ DC+ +LLE N+ R G + AA EG
Sbjct: 867 IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE--NKSNIDQRGYDGRNALRVAALEG 924
Query: 288 H----YLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHIS 343
H L + V K+A G ++ A E +ENG +V
Sbjct: 925 HRDIVELLFSHGADVNCKDA---DGRPTLYILALENQLTMAEYFLENGANV--------- 972
Query: 344 QSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLL 400
++ D E +TAL+ + +VL+A AD N + + L A + ++V+LL+
Sbjct: 973 EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLI 1032
Query: 401 SHGANVN 407
HGA V+
Sbjct: 1033 EHGAVVD 1039
Score = 106 bits (265), Expect = 5e-23
Identities = 89/362 (24%), Positives = 156/362 (43%), Gaps = 46/362 (12%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L+ A GH + + + A+D D +G L A Q +++ +LD
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE--NH 842
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
+ G TPL +A G L+E+G N ++ G P ++A ++G YD V L+++
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
+++DQ +A+ AA +G +DIV LL HG +V+ +D G L + A +
Sbjct: 903 KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE 286
E+ + G +V A +G + L + G+ + + +L+ Y N + + AA++
Sbjct: 963 EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQ 1022
Query: 287 GHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSY 346
GH + ++LLIE+G + DH
Sbjct: 1023 GH--------------------------------VKVVQLLIEHG-----AVVDHTC--- 1042
Query: 347 DDERKTALYFGVSNNDVHCTEVLLAAGADPN-LDPL--NCLLVAVRANNYEIVRLLLSHG 403
++ TAL + +VLL GADPN D + VA + + +I++LL +G
Sbjct: 1043 -NQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
Query: 404 AN 405
A+
Sbjct: 1102 AS 1103
Score = 105 bits (262), Expect = 1e-22
Identities = 87/359 (24%), Positives = 159/359 (44%), Gaps = 15/359 (4%)
Query: 53 QGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGE 112
+GH + + +D D+ G PL A + +++++L+ + +G
Sbjct: 725 KGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADV--DHTDNNGR 782
Query: 113 TPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQ 172
TPL A G V TLL G ++ + +G T L IA +G+ ++V TL+ +
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 173 PCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHK 232
W+ +H AA +G + I L++ G + D G P +A++ GH D ++ L+
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902
Query: 233 GGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLAL 292
++ DG + L AA G+ D + LL +G N + G ++ A E
Sbjct: 903 KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962
Query: 293 KYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERK 351
+Y + + A G T +H + + + +++LI DVN D+E++
Sbjct: 963 EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAA---------DNEKR 1013
Query: 352 TALYFGVSNNDVHCTEVLLAAGA--DPNLDP-LNCLLVAVRANNYEIVRLLLSHGANVN 407
+AL V ++L+ GA D + L +A + + ++V++LL HGA+ N
Sbjct: 1014 SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN 1072
Score = 96.7 bits (239), Expect = 5e-20
Identities = 92/328 (28%), Positives = 144/328 (43%), Gaps = 22/328 (6%)
Query: 89 QQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPL 148
Q++L++++ A E D T + +++RTLL+ G N + G T L
Sbjct: 494 QEVLQLLVKAGAHVNSE----DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLL 549
Query: 149 LIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDG 208
A GS D+V+ L+ L+ + + AA+QG +V L+ G N++ D
Sbjct: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQ 609
Query: 209 FGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGS 268
G T L AA GH +V+ L++ G V D + L AA GG+ D + LL++G
Sbjct: 610 DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE 669
Query: 269 GNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPIHSA-----ADGQNAQ 322
N + G + AAY GH +++L+ ++ N G T + A A +A
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHAS 729
Query: 323 CLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN 382
+ LLI+ G +V DH D + T L V ++LL GAD + N
Sbjct: 730 VVSLLIDRGAEV-----DHC----DKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN 780
Query: 383 ---CLLVAVRANNYEIVRLLLSHGANVN 407
LL A + +V LL GA V+
Sbjct: 781 GRTPLLAAASMGHASVVNTLLFWGAAVD 808
Score = 82.8 bits (203), Expect = 8e-16
Identities = 64/232 (27%), Positives = 106/232 (45%), Gaps = 4/232 (1%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A ++GH +Q ++ K +D+ G L A ++ + I+E++ S+ K
Sbjct: 887 ASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLF--SHGADVNCKDA 944
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS 169
DG L + + LE G + +G T L ++ +G +MV LI ++
Sbjct: 945 DGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHAD 1004
Query: 170 LDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 229
++ ++ SA+ AA QG +V LL++HG V G T L +AA+ GH DV++ L
Sbjct: 1005 VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
Query: 230 IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIH 281
+ G D G + + AA G+ I LL +YG S N P+H
Sbjct: 1065 LEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASS--LNGCSPSPVH 1114
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 120 bits (301), Expect = 3e-27
Identities = 111/420 (26%), Positives = 186/420 (44%), Gaps = 23/420 (5%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
LV+AI G E++ + K ++ D + PLH A +I+E+++ + +
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV--NA 69
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
K TPL AV + E V+ LL+ N ++ +TPL IA + L+
Sbjct: 70 KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
++++ +A+H AA G ++V LLL G N++ D + AA GH +V+
Sbjct: 130 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE 286
+ L+ G +V + L AA G + LL+ G N PN G+ P+H A Y
Sbjct: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
Query: 287 GHYLALKYLIPVTS-KNAIRKSGLTPIH-SAADGQNAQCLELLIENGFDVNTLLADHISQ 344
G + + LI + N + G TP+H +AA A CLELL+ NG DVN D
Sbjct: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD---- 305
Query: 345 SYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLVAVRANNYEIVRLLLS 401
KT L+ + ++ ++ +GA + + N L +A R + ++ L++
Sbjct: 306 -----GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT 360
Query: 402 HGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFD----CMHGDIFGNS 457
GA+ +H FP + R LL++G+ ++ D C+H G +
Sbjct: 361 SGADTAKRGIH---GMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGN 417
Score = 110 bits (275), Expect = 4e-24
Identities = 97/332 (29%), Positives = 141/332 (42%), Gaps = 14/332 (4%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A GHI ++ V + + D+K + PLH A + +++ +LD
Sbjct: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVD--MNEPNA 237
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDM-VSTLIKHNT 168
G TPL +A G V L++ G N KN+KG TPL A + + L+ +
Sbjct: 238 YGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGA 297
Query: 169 SLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEH 228
++ + +H A GR +++ G + D G TPL +AA YGH ++
Sbjct: 298 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 357
Query: 229 LIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGH 288
LI G D G L AA G DC LL G + P+ G +H AA G+
Sbjct: 358 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGN 417
Query: 289 YLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYD 347
L L+ + N K G +P+H AA N QCL L+ +G VN L D
Sbjct: 418 LECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDL---------D 468
Query: 348 DERKTAL-YFGVSNNDVHCTEVLLAAGADPNL 378
+ T L Y S+ D C E LL A+P +
Sbjct: 469 ERGCTPLHYAATSDTDGKCLEYLLRNDANPGI 500
Score = 103 bits (258), Expect = 3e-22
Identities = 91/335 (27%), Positives = 147/335 (43%), Gaps = 21/335 (6%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A GH L+ V+ +D + G PL A + + ++++++ L +
Sbjct: 557 AAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYIL 616
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNT---KNDKGETPLLIAVKKGSYDMVSTLIKH 166
TP+ A G E +R L+ N ++ G+TPL+++V G D V +L+
Sbjct: 617 K-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
++D +A+H A G ++ V LL+HG LRD G TP+ ++A GH VL
Sbjct: 676 GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735
Query: 227 EHLIHKGGDV---LALADD-GASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHR 282
L+ + A AD+ G + L A G+ C+ LLLE A P+H
Sbjct: 736 GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNA-FSPLHC 794
Query: 283 AAYEGHYLALKYLIPVTSK---NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLA 339
A + A + LI NA G TP+H+AA + +CL+LL+ + VN
Sbjct: 795 AVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN---- 850
Query: 340 DHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGA 374
S D KT L N + E+L+++ +
Sbjct: 851 -----SVDSTGKTPLMMAAENGQTNTVEMLVSSAS 880
Score = 100 bits (250), Expect = 3e-21
Identities = 96/363 (26%), Positives = 162/363 (44%), Gaps = 42/363 (11%)
Query: 73 DEKGWFPLHEAVVQPIQQILEIV-----LDASYKTLWEFKTCDGE-----TPLTLAVKAG 122
D++G+ +H + + L+++ LD +T D + +PL LA G
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHG 561
Query: 123 LVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTS-LDQPCVKRWSAM 181
+ + L++ + + +N G TPL +A KG + V LI S L + + + + +
Sbjct: 562 HHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPI 621
Query: 182 HEAAKQGRKDIVALLLKHG---GNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLA 238
H AA G + + LL+ + V ++DG G TPL ++ GH D + L++KG +V A
Sbjct: 622 HAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDA 681
Query: 239 LADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI-- 296
G + L A G+ +C+ LL++G + + G PIH +A GH L L+
Sbjct: 682 KDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQS 741
Query: 297 -------PVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDE 349
P T+ N G T +H A + C+ELL+E + Q +
Sbjct: 742 AASMDANPATADN----HGYTALHWACYNGHETCVELLLE----------QEVFQKTEGN 787
Query: 350 RKTALYFGVSNNDVHCTEVLL-AAGAD----PNLDPLNCLLVAVRANNYEIVRLLLSHGA 404
+ L+ V N++ E+L+ GA + L A ++ E ++LLLSH A
Sbjct: 788 AFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNA 847
Query: 405 NVN 407
VN
Sbjct: 848 QVN 850
Score = 94.7 bits (234), Expect = 2e-19
Identities = 101/457 (22%), Positives = 180/457 (39%), Gaps = 63/457 (13%)
Query: 39 PLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQI-LEIVLD 97
P + N L A G + E + +++ +EKG+ PLH A + LE+++
Sbjct: 235 PNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVG 294
Query: 98 ASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSY 157
K+ DG+TPL + G +T+++ G + ++ G TPL IA + G
Sbjct: 295 NGADV--NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352
Query: 158 DMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVA 217
+++TLI + + +H AA G D LL G ++ D FG T L A
Sbjct: 353 LLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAA 412
Query: 218 AEYGHCDVLEHLIHKGGD-----------------------VLALADDGASVL------- 247
A G+ + L L++ G D + AL GASV
Sbjct: 413 AAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGC 472
Query: 248 ----FEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNA 303
+ A + C+ LL + + ++ G+ +H +A GH L L+ + T +
Sbjct: 473 TPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDV 532
Query: 304 I-------------RKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDER 350
+ ++ ++P+H AA + Q LE+L+++ D++ +
Sbjct: 533 LMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDV---------RNSSG 583
Query: 351 KTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRA----NNYEIVRLLLSHGANV 406
+T L V C +VL+ GA + + A + E +RLL+ +
Sbjct: 584 RTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQ 643
Query: 407 NCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVE 443
N + + + P ++ + LLN G V+
Sbjct: 644 NAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVD 680
Score = 76.6 bits (187), Expect = 6e-14
Identities = 81/308 (26%), Positives = 131/308 (42%), Gaps = 19/308 (6%)
Query: 143 KGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGN 202
+ + L+ A+ G D V LI ++ ++ + +H AA G +I+ LL+ G
Sbjct: 7 RDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGAR 66
Query: 203 VHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLL 262
V+ +D +TPL A + ++ L+ DV A + + L AA C L
Sbjct: 67 VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
Query: 263 LEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNA 321
+ + NV +RAG +H AA+ GH +K L+ + NA K IH AA +
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
Query: 322 QCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGAD---PNL 378
+ ++LL+ +G +V D + T L+ S+ + + LL G D PN
Sbjct: 187 EVVKLLVSHGAEVT---------CKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNA 237
Query: 379 DPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSV--IQYALNDEVMLRLLL 436
L VA +V L+ GA VN N+ F + + + + L LL+
Sbjct: 238 YGNTPLHVACYNGQDVVVNELIDCGAIVN----QKNEKGFTPLHFAAASTHGALCLELLV 293
Query: 437 NNGYQVEM 444
NG V M
Sbjct: 294 GNGADVNM 301
Score = 61.2 bits (147), Expect = 3e-09
Identities = 79/334 (23%), Positives = 130/334 (38%), Gaps = 46/334 (13%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L+ ++ GH + + +D D+ G LH V ++ ++ +L K L
Sbjct: 657 LMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCL--L 714
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVW----PNTKNDKGETPLLIAVKKGSYDMVST 162
+ G TP+ L+ G + + LL+ P T ++ G T L A G V
Sbjct: 715 RDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVEL 774
Query: 163 LIKH--------NTSLDQPCV--------------------------KRWSAMHEAAKQG 188
L++ N C K + +H AA
Sbjct: 775 LLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTD 834
Query: 189 RKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGA-SVL 247
+ + LLL H V+ D G TPL +AAE G + +E L+ L L D+ + L
Sbjct: 835 HVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTAL 894
Query: 248 FEAAGGGNPDCISLLLEYGGSGNV---PNRAGHLPIHRAAYEGHYLALKYLI-PVTSKNA 303
A G+ L+LE N+ N A P+H AA G + ++ L+ S A
Sbjct: 895 HLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLA 954
Query: 304 IRKSGLTPIHSAADGQN-AQCLELLIENGFDVNT 336
+ ++G TP + A ++ A CL L++ V++
Sbjct: 955 VDENGYTPALACAPNKDVADCLALILATMMPVSS 988
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 119 bits (297), Expect = 1e-26
Identities = 102/369 (27%), Positives = 174/369 (47%), Gaps = 17/369 (4%)
Query: 44 NRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQ-PIQQILEIVLDASYKT 102
++ ++ +++ +IP L+ ++ +DE +E G PL A Q ++ + E++ + +
Sbjct: 6 SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65
Query: 103 LWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVST 162
L + D T L A K G V V LL+ GV ++ G T L+ A KG D+V
Sbjct: 66 L---EDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVEL 122
Query: 163 LIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGH 222
L+ H + + + AA +G DIV LLL++G V+ D +G TPL AA GH
Sbjct: 123 LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH 182
Query: 223 CDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHR 282
+ ++HL+ G DV + + L A GG + +L+ + N+ ++ G+ +
Sbjct: 183 LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMI 242
Query: 283 AAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADH 341
A+ EGH ++ L+ T N +SG T + A G + + + L++ D++ D+
Sbjct: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302
Query: 342 ISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRL 398
KTALY+ V + +L D + D L+ A + N E+V L
Sbjct: 303 ---------KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVEL 353
Query: 399 LLSHGANVN 407
LL GA V+
Sbjct: 354 LLDKGAKVS 362
Score = 103 bits (257), Expect = 4e-22
Identities = 84/333 (25%), Positives = 147/333 (44%), Gaps = 12/333 (3%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L+ A K+GH+ ++E +K ++ D GW L A + ++E++L S+
Sbjct: 75 LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL--SHGANPSV 132
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
P+ A G + V LL+ G N + G TPL+ A +KG + V L+
Sbjct: 133 TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
+DQ +A+ A K G V +LK NV+L D G T L +A++ GH +++
Sbjct: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIV 252
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE 286
+ L+ G V G +VL A GG+ + + LL+ ++ + ++ A +
Sbjct: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
Query: 287 GHYLALKYLIPVTSKNAI-RKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQS 345
G+ ++ ++ I K G TP+ A +N + +ELL++ G V+ +
Sbjct: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAV-------- 364
Query: 346 YDDERKTALYFGVSNNDVHCTEVLLAAGADPNL 378
D + T L+ + E+LL D L
Sbjct: 365 -DKKGDTPLHIAIRGRSRKLAELLLRNPKDGRL 396
Score = 75.5 bits (184), Expect = 1e-13
Identities = 86/324 (26%), Positives = 142/324 (43%), Gaps = 30/324 (9%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMD-EADEKGWFPLHEAVVQP----IQQILEIVLDASYK 101
LV A ++GH+ E VK+ AM + D++G + +V Q + EI+
Sbjct: 174 LVWAARKGHL----ECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNV 229
Query: 102 TLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVS 161
L + DG T L +A K G E V+ LL+ G + N + G+T L+ AV+ G ++V
Sbjct: 230 NLTDK---DGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVR 286
Query: 162 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYG 221
L++ +D +A++ A ++G +V +L+ + + G TPL A +
Sbjct: 287 ALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMR 346
Query: 222 HCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV---PNRAGHL 278
+ +V+E L+ KG V A+ G + L A G + LLL G + PN+AG
Sbjct: 347 NIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGET 406
Query: 279 PI-----HRAAYEGHYLALKYLIPVTSKN-----AIRKSGLTPIHSAADGQNAQCLELLI 328
P H+ + ++L P + + S L I S Q C+ L
Sbjct: 407 PYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYA 466
Query: 329 ENGFDVNTLLADHISQSYDDERKT 352
+ G + LL + +DE KT
Sbjct: 467 QWGSGKSFLL-----KKLEDEMKT 485
Score = 39.7 bits (91), Expect = 0.008
Identities = 42/158 (26%), Positives = 69/158 (43%), Gaps = 13/158 (8%)
Query: 255 NPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPIH 313
N + LLE + N G P+ AA +G+ +K LI + N T +
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 314 SAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAG 373
SA+ + +E L++ G ++ + D TAL + E+LL+ G
Sbjct: 77 SASKEGHVHIVEELLKCGVNL---------EHRDMGGWTALMWACYKGRTDVVELLLSHG 127
Query: 374 ADPNLDPLNC---LLVAVRANNYEIVRLLLSHGANVNC 408
A+P++ L ++ A + +IV LLL +GA VNC
Sbjct: 128 ANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC 165
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 118 bits (295), Expect = 2e-26
Identities = 99/370 (26%), Positives = 171/370 (46%), Gaps = 23/370 (6%)
Query: 45 RKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDA------ 98
R+L EA +Q ++ +QE + + + G LH A +Q + ++L+
Sbjct: 17 RQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDE 76
Query: 99 --SYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGS 156
+ L E + C G L L+ G + ++ L+ G + ++ G T L A +KG
Sbjct: 77 EDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGH 136
Query: 157 YDMVSTLIK--HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPL 214
+++ +++ + +LD +A H AA+ G+ D + L+ G + +++D G T L
Sbjct: 137 VPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTAL 196
Query: 215 GVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNR 274
+AA GH VL+ L+ G D+ +G + L AAGG +PDC+ LLL G + N +
Sbjct: 197 HLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQ 256
Query: 275 AGHLPIHRAAYEGHYLALKYLIPVTS-KNAIRKSGLTPIHSAADGQNAQCLELLIENGFD 333
+H AA G + LI N + G +P+H A + LLI + D
Sbjct: 257 KNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD 316
Query: 334 VNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRA 390
VN + D+ ++T L+ + ++LL AG D NL L VAVR+
Sbjct: 317 VNAV---------DNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRS 367
Query: 391 NNYEIVRLLL 400
N+ +V +++
Sbjct: 368 NHVSLVDMII 377
Score = 94.7 bits (234), Expect = 2e-19
Identities = 86/315 (27%), Positives = 139/315 (44%), Gaps = 31/315 (9%)
Query: 112 ETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLD 171
E L A + V ++ L+ + V +N G L A G V L++H ++D
Sbjct: 16 ERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75
Query: 172 QPCVKR----------WSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYG 221
+ +A+ +A G I+ +L+ G +H G+T L AA+ G
Sbjct: 76 EEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKG 135
Query: 222 HCDVLEHLIHKGGDVLALADD--GASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLP 279
H VL ++ DV D G + AA G D + L+ G NV ++ G+
Sbjct: 136 HVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTA 195
Query: 280 IHRAAYEGHYLALKYLIPV----TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVN 335
+H AA GH L+ L+ + +NA GLT +HSAA G + C++LL+ G VN
Sbjct: 196 LHLAAGRGHMAVLQRLVDIGLDLEEQNA---EGLTALHSAAGGSHPDCVQLLLRAGSTVN 252
Query: 336 TLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANN 392
L ++S L++ + + VL+ AG N+ + L +AVR N
Sbjct: 253 ALTQKNLS---------CLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNF 303
Query: 393 YEIVRLLLSHGANVN 407
+VRLL++ ++VN
Sbjct: 304 PALVRLLINSDSDVN 318
Score = 59.7 bits (143), Expect = 7e-09
Identities = 49/187 (26%), Positives = 88/187 (47%), Gaps = 2/187 (1%)
Query: 44 NRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTL 103
N L A +GH+ LQ V ++E + +G LH A ++++L A +
Sbjct: 193 NTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG--ST 250
Query: 104 WEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTL 163
T + L A +G + R L+ G N + +G +PL +AV+ +V L
Sbjct: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
Query: 164 IKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHC 223
I ++ ++ ++ + +H AA+ +DI +LL G +++LRD G T L VA H
Sbjct: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
Query: 224 DVLEHLI 230
+++ +I
Sbjct: 371 SLVDMII 377
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/250 (21%), Positives = 100/250 (40%), Gaps = 37/250 (14%)
Query: 50 AIKQGHIPELQEYVK--YKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFK 107
A ++GH+P L ++ A+D D+ G H A L+ ++ + K
Sbjct: 131 AAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDH--NVK 188
Query: 108 TCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHN 167
+G T L LA G + ++ L++ G+ +N +G T L A D V L++
Sbjct: 189 DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG 248
Query: 168 TSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGV---------------- 211
++++ K S +H AA G +D+ +L+ GG ++ D G
Sbjct: 249 STVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVR 308
Query: 212 -----------------TPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGG 254
TPL +AAE+ D+ + L+ G D+ G + L A
Sbjct: 309 LLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSN 368
Query: 255 NPDCISLLLE 264
+ + ++++
Sbjct: 369 HVSLVDMIIK 378
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 115 bits (289), Expect = 9e-26
Identities = 104/378 (27%), Positives = 166/378 (43%), Gaps = 32/378 (8%)
Query: 58 ELQEYVKYKYAMDEADEKGWF-PLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLT 116
E+ E + A A + W PLH AV ++ +++++ S K + +TPL
Sbjct: 30 EIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDK--NWQTPLH 87
Query: 117 LAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVK 176
+A V+ ++ N + G T L A G +MV+ L+ +++ K
Sbjct: 88 VAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKK 147
Query: 177 RWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDV 236
A+H AA G D+VALL+ HG V +D G TPL AA G +V++HL++ G ++
Sbjct: 148 DRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEI 207
Query: 237 LALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGH-YLALKYL 295
+ G + L A G ++ L++YG + N PN G P+H AA H L L+ L
Sbjct: 208 DEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL 267
Query: 296 I-PVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD-----HISQSYDDE 349
+ N K G +P+H A + LI+NG +++ + D H++ Y E
Sbjct: 268 VNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHE 327
Query: 350 ----------RKTA---------LYFGVSNNDVHCTEVLLAAGAD---PNLDPLNCLLVA 387
TA L+ N C LL++G + P+ CL A
Sbjct: 328 LLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAA 387
Query: 388 VRANNYEIVRLLLSHGAN 405
N E ++LL S GA+
Sbjct: 388 AAGGNVECIKLLQSSGAD 405
Score = 109 bits (272), Expect = 8e-24
Identities = 97/351 (27%), Positives = 164/351 (46%), Gaps = 29/351 (8%)
Query: 73 DEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLE 132
D++G+ +H A +Q LE++L+ + E + ++PL LA G + + LL+
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563
Query: 133 KGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSL-DQPCVKRWSAMHEAAKQGRKD 191
V + +++KG T L +A KG + V LI S+ + V + + +H + G
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTL 623
Query: 192 IVALLLKHGGN---VHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLF 248
+ LLL+ N V ++D G TPL +A YGH D + L+ K +V + G + L
Sbjct: 624 CLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALH 683
Query: 249 EAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI--PVTSKNAIRK 306
G+ +C+ +LLE S + G P+H AA GH L L+ ++ ++ K
Sbjct: 684 RGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFK 743
Query: 307 --SGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVH 364
G TP+H A N C+E+L+E + + T L+ + N+ +
Sbjct: 744 DNQGYTPLHWACYNGNENCIEVLLE----------QKCFRKFIGNPFTPLHCAIINDHGN 793
Query: 365 CTEVLLAAGADPNLDPLNC--------LLVAVRANNYEIVRLLLSHGANVN 407
C +LL A D ++ ++C L A A++ E ++LLL H A VN
Sbjct: 794 CASLLLGA-IDSSI--VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN 841
Score = 99.0 bits (245), Expect = 1e-20
Identities = 90/336 (26%), Positives = 146/336 (43%), Gaps = 21/336 (6%)
Query: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTC 109
A GH L+ ++ +D DEKG L A + + +E +++ +++
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPG-ASIFVKDNV 607
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWP---NTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
TPL +V G +R LLE P + K+ KG+TPL++AV G D VS L++
Sbjct: 608 TKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEK 667
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
++D + +A+H G ++ V +LL+ ++ +D G TPL AA GH L
Sbjct: 668 EANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWL 727
Query: 227 EHLIHKG---GDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRA 283
L+ D + G + L A GN +CI +LLE P+H A
Sbjct: 728 SELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP-FTPLHCA 786
Query: 284 AYEGHYLALKYLIPVTSKNAIR---KSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
H L+ + + G TP+ +AA + +CL+LL+ + VN +
Sbjct: 787 IINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAV--- 843
Query: 341 HISQSYDDERKTALYFGVSNNDVHCTEVLL-AAGAD 375
D+ KTAL N ++L+ +A AD
Sbjct: 844 ------DNSGKTALMMAAENGQAGAVDILVNSAQAD 873
Score = 95.5 bits (236), Expect = 1e-19
Identities = 92/349 (26%), Positives = 155/349 (44%), Gaps = 21/349 (6%)
Query: 105 EFKTCDGE--TPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVST 162
+ T D E TPL +A G E + L+ G N K++ TPL AV S + V
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 163 LIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGH 222
LIKH+ ++ + +H AA +++ +V++ D G T L AA GH
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 223 CDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHR 282
+++ L+ KG ++ A L AA G+ D ++LL+ +G ++ G+ P+H
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHA 187
Query: 283 AAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAA-DGQNAQCLELLIENGFDVNTLLAD 340
AA G +K+L+ + + I G T +H A +GQ+A E LI+ G +VN
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNE-LIDYGANVN----- 241
Query: 341 HISQSYDDERKTALYF-GVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIV 396
++ T L+F S + C E+L+ GAD N+ D + L + +
Sbjct: 242 ----QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRS 297
Query: 397 RLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMC 445
+ L+ +G ++C D P + E+++ L +G C
Sbjct: 298 QTLIQNGGEIDCV---DKDGNTPLHVAARYGHELLINTLRTSGADTAKC 343
Score = 94.4 bits (233), Expect = 3e-19
Identities = 85/323 (26%), Positives = 138/323 (42%), Gaps = 21/323 (6%)
Query: 45 RKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAV----VQPIQQILEIVLDASY 100
R L A GH+ + + + + D+KG+ PLH A + ++ +L + ++
Sbjct: 150 RALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDE 209
Query: 101 KTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDM- 159
++ G T L +A G V L++ G N N+ G TPL A +
Sbjct: 210 INVY------GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALC 263
Query: 160 VSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAE 219
+ L+ + ++ S +H A GR L+++GG + D G TPL VAA
Sbjct: 264 LELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAAR 323
Query: 220 YGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLP 279
YGH ++ L G D L AA + DC LL G + P++ G
Sbjct: 324 YGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTC 383
Query: 280 IHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLL 338
+H AA G+ +K L + + K G TP+H AA + C+E L+ G +VN
Sbjct: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN--- 440
Query: 339 ADHISQSYDDERKTALYFGVSNN 361
DD +TAL++ +++
Sbjct: 441 ------ETDDWGRTALHYAAASD 457
Score = 75.5 bits (184), Expect = 1e-13
Identities = 94/389 (24%), Positives = 158/389 (40%), Gaps = 60/389 (15%)
Query: 78 FPLHEAVVQPIQQILEIVLDASYKTLWEFKTCD--GETPLTLAVKAGLVENVRTLLEKGV 135
FPLH A + +L + + E T D G T L A G VE ++ L G
Sbjct: 349 FPLHLAALNAHSDCCRKLLSSGF----EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA 404
Query: 136 WPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQG---RKDI 192
+ K+ G TPL A + + TL+ ++++ +A+H AA K I
Sbjct: 405 DFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTI 464
Query: 193 VA-------------------------LLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLE 227
+ LL++ N +RD G + AA YGH LE
Sbjct: 465 LGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLE 524
Query: 228 HLIHKGGDVLALADDGA--SVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAY 285
L+ + +D GA S L AA G+ + +LL+ ++ + G + AA+
Sbjct: 525 LLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAF 584
Query: 286 EGHYLALKYLI----PVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADH 341
+GH ++ LI + K+ + K TP+H++ + CL LL+E +AD+
Sbjct: 585 KGHTECVEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLE--------IADN 634
Query: 342 --ISQSYDDERKTALYFGVSNNDVHCTEVLLAAGAD-PNLDPLNCLLV--AVRANNYEIV 396
D + +T L V+ + +LL A+ +D L C + + + E V
Sbjct: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
Query: 397 RLLLSHGANVNCYFMHVNDTRFPSVIQYA 425
++LL ++ C D+R + + YA
Sbjct: 695 QMLLEQEVSILC-----KDSRGRTPLHYA 718
Score = 67.0 bits (162), Expect = 5e-11
Identities = 68/282 (24%), Positives = 122/282 (43%), Gaps = 38/282 (13%)
Query: 195 LLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGG 254
+L+ +V+ D TPL VAA G +++E LI G V A + + L A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 255 NPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIP-VTSKNAIRKSGLTPIH 313
+ + + +L+++ N ++ P+H AA + +IP ++S N + G T +H
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 314 SAADGQNAQCLELLIENGFDVN----------------------TLLADHISQSYDDERK 351
AA + + + LL+ G ++N LL +H ++ ++K
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
Query: 352 --TALYFGVSNNDVHCTEVLLAAGADPNLDPLN-----CLLVAVRANNYEIVRLLLSHGA 404
T L+ SN ++ + LL G + +D +N L +A +V L+ +GA
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVE--IDEINVYGNTALHIACYNGQDAVVNELIDYGA 238
Query: 405 NVNCYFMHVNDTRFPSV--IQYALNDEVMLRLLLNNGYQVEM 444
NVN N+ F + + + + L LL+NNG V +
Sbjct: 239 NVN----QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNI 276
Score = 65.9 bits (159), Expect = 1e-10
Identities = 63/253 (24%), Positives = 111/253 (43%), Gaps = 19/253 (7%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L+ A+ GHI + ++ + +D D G LH ++ ++ ++++L+ L
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL--C 706
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNT---KNDKGETPLLIAVKKGSYDMVSTL 163
K G TPL A G + LL+ + K+++G TPL A G+ + + L
Sbjct: 707 KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
Query: 164 IKHNTSLDQPCVKR-----WSAMHEAAKQGRKDIVALLLK--HGGNVHLRDGFGVTPLGV 216
L+Q C ++ ++ +H A + +LLL V RD G TPL
Sbjct: 767 ------LEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRA 820
Query: 217 AAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSG-NVPNRA 275
AA H + L+ L+ V A+ + G + L AA G + +L+ + V ++
Sbjct: 821 AAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKD 880
Query: 276 GHLPIHRAAYEGH 288
+ P+H A +GH
Sbjct: 881 LNTPLHLACSKGH 893
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 115 bits (287), Expect = 1e-25
Identities = 105/393 (26%), Positives = 169/393 (43%), Gaps = 64/393 (16%)
Query: 43 QNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKT 102
Q +KLV+AI G +L + ++QP Q +++ LD+
Sbjct: 406 QKKKLVDAIVSGDTSKLMK----------------------ILQP--QDVDLALDS---- 437
Query: 103 LWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVST 162
G + L LAV+AG E + LL PN N +G TPL +AV++ +V
Sbjct: 438 --------GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
Query: 163 LIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGH 222
L+ S++ +W+A+H AA+ G + LLL+ +V+ D G TP+ VA ++G
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
Query: 223 CDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGG-SGNVPNRAGHLPIH 281
+++ L+ +G DV D L AA G+ + LL + G S N G P+H
Sbjct: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLH 609
Query: 282 RAAYEGHYLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 340
AA GHY + LI + S N TP+H AA+ + LL+ G + +D
Sbjct: 610 LAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD 669
Query: 341 HISQSYDDER------------------------KTALYFGVSNNDVHCTEVLLAAGADP 376
+ + R +TAL+ ++ E L++A
Sbjct: 670 GYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVID 729
Query: 377 NLDP--LNCLLVAVRANNYEIVRLLLSHGANVN 407
D L+ L +A + + + V LL HGA++N
Sbjct: 730 LFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 105 EFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLI 164
E T DG T L LA + G + V+ L+E+ + +T L +A G ++V L+
Sbjct: 664 EAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV 723
Query: 165 KHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLR 206
+ +D + SA+H AA+ V LL+HG +++L+
Sbjct: 724 SADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQ 764
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 114 bits (284), Expect = 3e-25
Identities = 99/339 (29%), Positives = 153/339 (45%), Gaps = 61/339 (17%)
Query: 79 PLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPN 138
PLH A + QI+ ++L+ + K+ G TPL A ++ E V+ L+ P+
Sbjct: 258 PLHWAALLGHAQIVHLLLERN-KSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH---PS 313
Query: 139 TKND---KGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRW--SAMHEAAKQGRKDIV 193
K+D +G T + A KGS D++ T++ + +D ++ +A+H AA G V
Sbjct: 314 VKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTV 373
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
LLL++ V D TPL A E GH DV++ LI G V + DG S+L AA G
Sbjct: 374 KLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALG 433
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIH 313
GN D +L+E + NV + AG P+ AAY G+
Sbjct: 434 GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY------------------------- 468
Query: 314 SAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAG 373
C+ +L+EN D N D E +TAL++ +N + ++LL
Sbjct: 469 -------INCMAVLMENNADPNI---------QDKEGRTALHWSCNNGYLDAIKLLLDFA 512
Query: 374 ADPN--------LDPLNCLLVAVRANNYEIVRLLLSHGA 404
A PN PL+ L+ R +E+++ +L HGA
Sbjct: 513 AFPNQMENNEERYTPLDYALLGER---HEVIQFMLEHGA 548
Score = 55.1 bits (131), Expect = 2e-07
Identities = 64/288 (22%), Positives = 118/288 (40%), Gaps = 21/288 (7%)
Query: 128 RTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQ 187
R ++ + ++ G TPL+ V D L+K +++ + +A+H AA++
Sbjct: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
Query: 188 GRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIH--KGGDVLALADDGAS 245
G + LLL N +D +TPL + + L L+ G+V + +
Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151
Query: 246 VLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLA---LKYLIPVTSKN 302
L +A NP+ + LL+++ + +P+ G +P+H AA A ++ ++
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 303 AIRK----SGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGV 358
++ G TP+H A N + DV T SYD+ +T L++
Sbjct: 212 SLLNWQDYEGRTPLHFAVADGNVTVV--------DVLTSYESCNITSYDNLFRTPLHWAA 263
Query: 359 SNNDVHCTEVLL---AAGADP-NLDPLNCLLVAVRANNYEIVRLLLSH 402
+LL +G P + L A ++N E V++ L H
Sbjct: 264 LLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Score = 35.8 bits (81), Expect = 0.11
Identities = 30/97 (30%), Positives = 45/97 (46%), Gaps = 11/97 (11%)
Query: 312 IHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLA 371
+H+AA + L+ LI N+ L D D +T L + V + + C + LL
Sbjct: 18 VHAAAVNGDKGALQRLIVG----NSALKD----KEDQFGRTPLMYCVLADRLDCADALLK 69
Query: 372 AGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGAN 405
AGAD N L +A + NY ++LLL+ AN
Sbjct: 70 AGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN 106
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 114 bits (284), Expect = 3e-25
Identities = 99/339 (29%), Positives = 153/339 (45%), Gaps = 61/339 (17%)
Query: 79 PLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPN 138
PLH A + QI+ ++L+ + K+ G TPL A ++ E V+ L+ P+
Sbjct: 258 PLHWAALLGHAQIVHLLLERN-KSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH---PS 313
Query: 139 TKND---KGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRW--SAMHEAAKQGRKDIV 193
K+D +G T + A KGS D++ T++ + +D ++ +A+H AA G V
Sbjct: 314 VKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTV 373
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
LLL++ V D TPL A E GH DV++ LI G V + DG S+L AA G
Sbjct: 374 KLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALG 433
Query: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIH 313
GN D +L+E + NV + AG P+ AAY G+
Sbjct: 434 GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY------------------------- 468
Query: 314 SAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAG 373
C+ +L+EN D N D E +TAL++ +N + ++LL
Sbjct: 469 -------INCMAVLMENNADPNI---------QDKEGRTALHWSCNNGYLDAIKLLLDFA 512
Query: 374 ADPN--------LDPLNCLLVAVRANNYEIVRLLLSHGA 404
A PN PL+ L+ R +E+++ +L HGA
Sbjct: 513 AFPNQMENNEERYTPLDYALLGER---HEVIQFMLEHGA 548
Score = 55.1 bits (131), Expect = 2e-07
Identities = 64/288 (22%), Positives = 118/288 (40%), Gaps = 21/288 (7%)
Query: 128 RTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQ 187
R ++ + ++ G TPL+ V D L+K +++ + +A+H AA++
Sbjct: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
Query: 188 GRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIH--KGGDVLALADDGAS 245
G + LLL N +D +TPL + + L L+ G+V + +
Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151
Query: 246 VLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLA---LKYLIPVTSKN 302
L +A NP+ + LL+++ + +P+ G +P+H AA A ++ ++
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 303 AIRK----SGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGV 358
++ G TP+H A N + DV T SYD+ +T L++
Sbjct: 212 SLLNWQDYEGRTPLHFAVADGNVTVV--------DVLTSYESCNITSYDNLFRTPLHWAA 263
Query: 359 SNNDVHCTEVLL---AAGADP-NLDPLNCLLVAVRANNYEIVRLLLSH 402
+LL +G P + L A ++N E V++ L H
Sbjct: 264 LLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Score = 35.8 bits (81), Expect = 0.11
Identities = 30/97 (30%), Positives = 45/97 (46%), Gaps = 11/97 (11%)
Query: 312 IHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLA 371
+H+AA + L+ LI N+ L D D +T L + V + + C + LL
Sbjct: 18 VHAAAVNGDKGALQRLIVG----NSALKD----KEDQFGRTPLMYCVLADRLDCADALLK 69
Query: 372 AGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGAN 405
AGAD N L +A + NY ++LLL+ AN
Sbjct: 70 AGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN 106
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 114 bits (284), Expect = 3e-25
Identities = 94/368 (25%), Positives = 167/368 (45%), Gaps = 11/368 (2%)
Query: 42 AQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYK 101
+ NR L EA +G + +++ + +++E E+G L A ++ +++L A +
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL-AMHA 291
Query: 102 TLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVS 161
+ + TPL A G V+ V+ LL N ++ G T L A G D+V
Sbjct: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
Query: 162 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDG-FGVTPLGVAAEY 220
L++ S++ + + EA G ++ LLL++G ++ F + L +A
Sbjct: 352 VLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK 411
Query: 221 GHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPI 280
GH +++ L+ G D D+ + L EA G+ + LLL+ G N+P + P+
Sbjct: 412 GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 471
Query: 281 HRAAYEGHY-LALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLA 339
AA GH LA + S + G TP+ AA + + + LL+ G ++N
Sbjct: 472 TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA--- 528
Query: 340 DHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLL 399
++ ++TAL + + L+ AGAD L L+ A + + E+V+ L
Sbjct: 529 -----QTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYL 583
Query: 400 LSHGANVN 407
L+ GANV+
Sbjct: 584 LAAGANVH 591
Score = 108 bits (271), Expect = 1e-23
Identities = 101/365 (27%), Positives = 166/365 (45%), Gaps = 16/365 (4%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L+ A GH+ ++ + +K ++ G L A +++++L++ E
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI--ED 362
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNT-KNDKGETPLLIAVKKGSYDMVSTLIK 165
+G TPL A AG VE R LLE G NT N+ E+ L +A KG +MV L++
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 166 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
+ + +A+ EA G ++ LLL G V++ +PL +AA GH ++
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAY 285
LI +G + + D+G + L EAA G+ + ++LLL G + N A
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
Query: 286 EGHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQS 345
G +L + + + + I TP+ AA + + ++ L+ G +V H + +
Sbjct: 543 CGGFLEVADFL-IKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANV------HATTA 595
Query: 346 YDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDP---LNCLLVAVRANNYEIVRLLLSH 402
D TAL + N +VLL AGAD + L+ A RA + V+ L+S
Sbjct: 596 TGD---TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Query: 403 GANVN 407
GANVN
Sbjct: 653 GANVN 657
Score = 106 bits (265), Expect = 5e-23
Identities = 90/308 (29%), Positives = 149/308 (48%), Gaps = 23/308 (7%)
Query: 112 ETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLD 171
+T LTLA G E V+TLLE+G ++ KG TPL++A G +V L+ + ++
Sbjct: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 1143
Query: 172 QPCVK-RWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 230
+ + + + A GR+++V LLL G N R+ TPL +AA G+ ++++ L+
Sbjct: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203
Query: 231 HKGGDVLALADD--GASVLFEAAGGGNPDCISLLLEYGGSGNV---PNRAGHLPIHRAAY 285
+ G ++ + G S L AA G+ + LLL+ G N NR L + A +
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL--ACF 1261
Query: 286 EGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQ 344
+G + L+ + R K+GLTP+ AA G A+ +L++ G DVN +
Sbjct: 1262 QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN-------AP 1314
Query: 345 SYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN-----CLLVAVRANNYEIVRLL 399
R TAL E+L+ GA ++D N L +A + ++V+LL
Sbjct: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGA--HIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
Query: 400 LSHGANVN 407
+ GA+V+
Sbjct: 1373 VQAGADVD 1380
Score = 96.7 bits (239), Expect = 5e-20
Identities = 98/374 (26%), Positives = 171/374 (45%), Gaps = 25/374 (6%)
Query: 41 SAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLD--A 98
S N L A G++ ++ ++ ++++ +E G PL EA ++ ++L+ A
Sbjct: 332 STGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGA 391
Query: 99 SYKT-LWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSY 157
T EFK E+ LTLA G +E VR LLE G K D+ T L+ A G
Sbjct: 392 GINTHSNEFK----ESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447
Query: 158 DMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVA 217
++ L+ ++ P S + AA G ++ ALL++ G ++ + G TPL A
Sbjct: 448 EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507
Query: 218 AEYGHCDVLEHLIHKGGDVLALADD-GASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAG 276
A GH +++ L+ +G ++ A ++ + L A GG + L++ G +
Sbjct: 508 AREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GC 564
Query: 277 HLPIHRAAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVN 335
P+ AA EGH +KYL+ + +A +G T + A + + ++L++ G D+
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL- 623
Query: 336 TLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN----CLLVAVRAN 391
+H S+ +T L V + L++ GA+ N N L +A
Sbjct: 624 ----EHESEG----GRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGG 675
Query: 392 NYEIVRLLLSHGAN 405
+ +V LLL+HGA+
Sbjct: 676 HLAVVELLLAHGAD 689
Score = 93.2 bits (230), Expect = 6e-19
Identities = 81/308 (26%), Positives = 135/308 (43%), Gaps = 15/308 (4%)
Query: 115 LTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPC 174
L A G V VR LL +G N ++GE+ L +A G Y++ L+ + +++
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 175 VKR-WSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKG 233
+K + + AA G IV LLL H +V+ + G T L A G+ DV++ L+ G
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
Query: 234 GDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV-PNRAGHLPIHRAAYEGHYLAL 292
+ ++G + L EA G+ + LLLE G N N + A Y+GH +
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417
Query: 293 KYLIPVTSKNAIRKSGL-TPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERK 351
++L+ + + + T + A + + LL+++G VN D +
Sbjct: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---------DSFE 468
Query: 352 TALYFGVSNNDVHCTEVLLAAGA---DPNLDPLNCLLVAVRANNYEIVRLLLSHGANVNC 408
+ L V +L+ GA + N + L+ A R + E+V LLL GAN+N
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 409 YFMHVNDT 416
+T
Sbjct: 529 QTEETQET 536
Score = 88.6 bits (218), Expect = 1e-17
Identities = 86/303 (28%), Positives = 141/303 (46%), Gaps = 11/303 (3%)
Query: 41 SAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASY 100
S + L A GH +Q ++ +++ D+KG+ PL A ++EI+LD
Sbjct: 1081 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 1140
Query: 101 KTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMV 160
+ + +TPL+LA G E V LL +G +N TPL +A G +++
Sbjct: 1141 DIEAQSERTK-DTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
Query: 161 STLIKHNTSLDQPCVKRW--SAMHEAAKQGRKDIVALLLKHGGNVHLR-DGFGVTPLGVA 217
L+ ++ + S + AA G V LLL G +++ + + T L +A
Sbjct: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259
Query: 218 AEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVP----N 273
G +V+ L+ + +V A G + L EAA GG + +LL+ G N P +
Sbjct: 1260 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1319
Query: 274 RAGHLPIHRAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADGQNAQCLELLIENGF 332
R L I AA +GHY + LI + +R K G TP+ AA+G + ++LL++ G
Sbjct: 1320 RDTALTI--AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1377
Query: 333 DVN 335
DV+
Sbjct: 1378 DVD 1380
Score = 84.7 bits (208), Expect = 2e-16
Identities = 79/316 (25%), Positives = 134/316 (42%), Gaps = 35/316 (11%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L A +GH+ ++ ++ + ++ L EA + ++ ++LD+ +
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV--NM 462
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLI-- 164
E+PLTLA G VE L+E+G ND+G TPL+ A ++G +MV+ L+
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 165 ----------KHNTSLDQPCVKRW-------------------SAMHEAAKQGRKDIVAL 195
T+L C + + + EAA++G ++V
Sbjct: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKY 582
Query: 196 LLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGN 255
LL G NVH G T L A E GH DV + L+ G D+ ++ G + L +AA G+
Sbjct: 583 LLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 642
Query: 256 PDCISLLLEYGGSGN-VPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIH 313
+ L+ G + N H + A GH ++ L+ + R K G T +
Sbjct: 643 VCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 702
Query: 314 SAADGQNAQCLELLIE 329
AA G + + L++
Sbjct: 703 EAAKGGHTSVVCYLLD 718
Score = 83.6 bits (205), Expect = 5e-16
Identities = 97/373 (26%), Positives = 154/373 (41%), Gaps = 37/373 (9%)
Query: 89 QQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETP- 147
Q LE +L+A+ + + T DG+ V L +V L++ T+ T
Sbjct: 172 QARLEALLEAA--GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTAN 229
Query: 148 --------LLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKH 199
L A +G + V L+ S+++ + S + A G ++ +LL
Sbjct: 230 AGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM 289
Query: 200 GGNVHLRDGFG-VTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDC 258
NV R G +TPL AA GH +++ L+ DV A + G + L A GG D
Sbjct: 290 HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDV 349
Query: 259 ISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIP-----VTSKNAIRKSGLTPIH 313
+ +LLE G S N GH P+ A GH + L+ T N ++S LT
Sbjct: 350 VKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT--- 406
Query: 314 SAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAG 373
A + + + L+E G D + DE TAL + V +LL +G
Sbjct: 407 LACYKGHLEMVRFLLEAGAD---------QEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
Query: 374 ADPNLDP---LNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYAL-NDE 429
A N+ + L +A + E+ LL+ GA++ VND + +++ A E
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLE----EVNDEGYTPLMEAAREGHE 513
Query: 430 VMLRLLLNNGYQV 442
M+ LLL G +
Sbjct: 514 EMVALLLGQGANI 526
Score = 74.3 bits (181), Expect = 3e-13
Identities = 67/256 (26%), Positives = 108/256 (42%), Gaps = 40/256 (15%)
Query: 79 PLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPN 138
PL A Q+++E++L E + TPL+LA G V ++ LL G N
Sbjct: 1153 PLSLACSGGRQEVVELLLARGANK--EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1210
Query: 139 TKNDK--GETPLLIAVKKGSYDMVSTLIKHNTSLD-QPCVKRWSAMHEAAKQGRKDIVAL 195
++ G +PL++A G V L+ + ++ Q R +A+ A QGR ++V+L
Sbjct: 1211 SRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSL 1270
Query: 196 LLKHGGNVHLRDGFGVTPL-----------------------------------GVAAEY 220
LL NV R G+TPL +AA+
Sbjct: 1271 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1330
Query: 221 GHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPI 280
GH E LI +G + G + L+ AA GG+ D + LL++ G + + P+
Sbjct: 1331 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1390
Query: 281 HRAAYEGHYLALKYLI 296
A +GH ++YL+
Sbjct: 1391 MAAFRKGHVKVVRYLV 1406
Score = 72.4 bits (176), Expect = 1e-12
Identities = 62/258 (24%), Positives = 109/258 (42%), Gaps = 30/258 (11%)
Query: 38 VPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVL- 96
+P + L A GH+ ++ +++E +++G+ PL EA + ++++ ++L
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG 521
Query: 97 ---------DASYKTLWEFKTCDG-------------------ETPLTLAVKAGLVENVR 128
+ + +T C G TPL A + G +E V+
Sbjct: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVK 581
Query: 129 TLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQG 188
LL G + G+T L A + G D+ L++ L+ + + +AA+ G
Sbjct: 582 YLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 641
Query: 189 RKDIVALLLKHGGNVHLRDGFGV-TPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVL 247
V L+ G NV+ T L +A GH V+E L+ G D DG+++L
Sbjct: 642 HVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 701
Query: 248 FEAAGGGNPDCISLLLEY 265
EAA GG+ + LL+Y
Sbjct: 702 IEAAKGGHTSVVCYLLDY 719
Score = 62.4 bits (150), Expect = 1e-09
Identities = 54/191 (28%), Positives = 89/191 (46%), Gaps = 3/191 (1%)
Query: 76 GWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGV 135
G PL A + ++++LD + +T + T LTLA G E V LL++
Sbjct: 1218 GISPLMLAAMNGHTAAVKLLLDMGSDINAQIET-NRNTALTLACFQGRTEVVSLLLDRKA 1276
Query: 136 WPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCV--KRWSAMHEAAKQGRKDIV 193
+ G TPL+ A G ++ L+ ++ P V R +A+ AA +G
Sbjct: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
LL+ G ++ +R+ G TPL +AA GH DV++ L+ G DV A + + L A
Sbjct: 1337 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1396
Query: 254 GNPDCISLLLE 264
G+ + L++
Sbjct: 1397 GHVKVVRYLVK 1407
Score = 50.8 bits (120), Expect = 3e-06
Identities = 44/161 (27%), Positives = 74/161 (45%), Gaps = 3/161 (1%)
Query: 79 PLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPN 138
PL EA + ++++ +L A T G+T LT A + G + LL+ G
Sbjct: 567 PLMEAAQEGHLELVKYLLAAGANV--HATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 139 TKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKR-WSAMHEAAKQGRKDIVALLL 197
+++ G TPL+ A + G V LI ++++ + + A G +V LLL
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
Query: 198 KHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLA 238
HG + R G T L AA+ GH V+ +L+ ++L+
Sbjct: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLS 725
Score = 50.1 bits (118), Expect = 6e-06
Identities = 37/156 (23%), Positives = 67/156 (42%)
Query: 43 QNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKT 102
+N L A QG + + K ++ + G PL EA ++ ++LD
Sbjct: 1252 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
Query: 103 LWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVST 162
+T LT+A G + L+ +G + +N KG TPL +A G D+V
Sbjct: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
Query: 163 LIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLK 198
L++ +D ++ + + A ++G +V L+K
Sbjct: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 114 bits (284), Expect = 3e-25
Identities = 94/368 (25%), Positives = 167/368 (45%), Gaps = 11/368 (2%)
Query: 42 AQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYK 101
+ NR L EA +G + +++ + +++E E+G L A ++ +++L A +
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLL-AMHA 291
Query: 102 TLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVS 161
+ + TPL A G V+ V+ LL N ++ G T L A G D+V
Sbjct: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
Query: 162 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDG-FGVTPLGVAAEY 220
L++ S++ + + EA G ++ LLL++G ++ F + L +A
Sbjct: 352 VLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK 411
Query: 221 GHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPI 280
GH +++ L+ G D D+ + L EA G+ + LLL+ G N+P + P+
Sbjct: 412 GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 471
Query: 281 HRAAYEGHY-LALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLA 339
AA GH LA + S + G TP+ AA + + + LL+ G ++N
Sbjct: 472 TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA--- 528
Query: 340 DHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLL 399
++ ++TAL + + L+ AGAD L L+ A + + E+V+ L
Sbjct: 529 -----QTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYL 583
Query: 400 LSHGANVN 407
L+ GANV+
Sbjct: 584 LAAGANVH 591
Score = 108 bits (271), Expect = 1e-23
Identities = 101/365 (27%), Positives = 166/365 (45%), Gaps = 16/365 (4%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L+ A GH+ ++ + +K ++ G L A +++++L++ E
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI--ED 362
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNT-KNDKGETPLLIAVKKGSYDMVSTLIK 165
+G TPL A AG VE R LLE G NT N+ E+ L +A KG +MV L++
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 166 HNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
+ + +A+ EA G ++ LLL G V++ +PL +AA GH ++
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAY 285
LI +G + + D+G + L EAA G+ + ++LLL G + N A
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
Query: 286 EGHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQS 345
G +L + + + + I TP+ AA + + ++ L+ G +V H + +
Sbjct: 543 CGGFLEVADFL-IKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANV------HATTA 595
Query: 346 YDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDP---LNCLLVAVRANNYEIVRLLLSH 402
D TAL + N +VLL AGAD + L+ A RA + V+ L+S
Sbjct: 596 TGD---TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Query: 403 GANVN 407
GANVN
Sbjct: 653 GANVN 657
Score = 106 bits (265), Expect = 5e-23
Identities = 90/308 (29%), Positives = 149/308 (48%), Gaps = 23/308 (7%)
Query: 112 ETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLD 171
+T LTLA G E V+TLLE+G ++ KG TPL++A G +V L+ + ++
Sbjct: 833 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 892
Query: 172 QPCVK-RWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 230
+ + + + A GR+++V LLL G N R+ TPL +AA G+ ++++ L+
Sbjct: 893 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 952
Query: 231 HKGGDVLALADD--GASVLFEAAGGGNPDCISLLLEYGGSGNV---PNRAGHLPIHRAAY 285
+ G ++ + G S L AA G+ + LLL+ G N NR L + A +
Sbjct: 953 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL--ACF 1010
Query: 286 EGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQ 344
+G + L+ + R K+GLTP+ AA G A+ +L++ G DVN +
Sbjct: 1011 QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN-------AP 1063
Query: 345 SYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN-----CLLVAVRANNYEIVRLL 399
R TAL E+L+ GA ++D N L +A + ++V+LL
Sbjct: 1064 PVPSSRDTALTIAADKGHYKFCELLIGRGA--HIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
Query: 400 LSHGANVN 407
+ GA+V+
Sbjct: 1122 VQAGADVD 1129
Score = 96.7 bits (239), Expect = 5e-20
Identities = 98/374 (26%), Positives = 171/374 (45%), Gaps = 25/374 (6%)
Query: 41 SAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLD--A 98
S N L A G++ ++ ++ ++++ +E G PL EA ++ ++L+ A
Sbjct: 332 STGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGA 391
Query: 99 SYKT-LWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSY 157
T EFK E+ LTLA G +E VR LLE G K D+ T L+ A G
Sbjct: 392 GINTHSNEFK----ESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447
Query: 158 DMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVA 217
++ L+ ++ P S + AA G ++ ALL++ G ++ + G TPL A
Sbjct: 448 EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507
Query: 218 AEYGHCDVLEHLIHKGGDVLALADD-GASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAG 276
A GH +++ L+ +G ++ A ++ + L A GG + L++ G +
Sbjct: 508 AREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GC 564
Query: 277 HLPIHRAAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVN 335
P+ AA EGH +KYL+ + +A +G T + A + + ++L++ G D+
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL- 623
Query: 336 TLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN----CLLVAVRAN 391
+H S+ +T L V + L++ GA+ N N L +A
Sbjct: 624 ----EHESEG----GRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGG 675
Query: 392 NYEIVRLLLSHGAN 405
+ +V LLL+HGA+
Sbjct: 676 HLAVVELLLAHGAD 689
Score = 93.2 bits (230), Expect = 6e-19
Identities = 81/308 (26%), Positives = 135/308 (43%), Gaps = 15/308 (4%)
Query: 115 LTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPC 174
L A G V VR LL +G N ++GE+ L +A G Y++ L+ + +++
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 175 VKR-WSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKG 233
+K + + AA G IV LLL H +V+ + G T L A G+ DV++ L+ G
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
Query: 234 GDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV-PNRAGHLPIHRAAYEGHYLAL 292
+ ++G + L EA G+ + LLLE G N N + A Y+GH +
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417
Query: 293 KYLIPVTSKNAIRKSGL-TPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERK 351
++L+ + + + T + A + + LL+++G VN D +
Sbjct: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---------DSFE 468
Query: 352 TALYFGVSNNDVHCTEVLLAAGA---DPNLDPLNCLLVAVRANNYEIVRLLLSHGANVNC 408
+ L V +L+ GA + N + L+ A R + E+V LLL GAN+N
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 409 YFMHVNDT 416
+T
Sbjct: 529 QTEETQET 536
Score = 88.6 bits (218), Expect = 1e-17
Identities = 86/303 (28%), Positives = 141/303 (46%), Gaps = 11/303 (3%)
Query: 41 SAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASY 100
S + L A GH +Q ++ +++ D+KG+ PL A ++EI+LD
Sbjct: 830 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
Query: 101 KTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMV 160
+ + +TPL+LA G E V LL +G +N TPL +A G +++
Sbjct: 890 DIEAQSERTK-DTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
Query: 161 STLIKHNTSLDQPCVKRW--SAMHEAAKQGRKDIVALLLKHGGNVHLR-DGFGVTPLGVA 217
L+ ++ + S + AA G V LLL G +++ + + T L +A
Sbjct: 949 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1008
Query: 218 AEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVP----N 273
G +V+ L+ + +V A G + L EAA GG + +LL+ G N P +
Sbjct: 1009 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1068
Query: 274 RAGHLPIHRAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADGQNAQCLELLIENGF 332
R L I AA +GHY + LI + +R K G TP+ AA+G + ++LL++ G
Sbjct: 1069 RDTALTI--AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1126
Query: 333 DVN 335
DV+
Sbjct: 1127 DVD 1129
Score = 84.7 bits (208), Expect = 2e-16
Identities = 79/316 (25%), Positives = 134/316 (42%), Gaps = 35/316 (11%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L A +GH+ ++ ++ + ++ L EA + ++ ++LD+ +
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV--NM 462
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLI-- 164
E+PLTLA G VE L+E+G ND+G TPL+ A ++G +MV+ L+
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 165 ----------KHNTSLDQPCVKRW-------------------SAMHEAAKQGRKDIVAL 195
T+L C + + + EAA++G ++V
Sbjct: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKY 582
Query: 196 LLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGN 255
LL G NVH G T L A E GH DV + L+ G D+ ++ G + L +AA G+
Sbjct: 583 LLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 642
Query: 256 PDCISLLLEYGGSGN-VPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIH 313
+ L+ G + N H + A GH ++ L+ + R K G T +
Sbjct: 643 VCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 702
Query: 314 SAADGQNAQCLELLIE 329
AA G + + L++
Sbjct: 703 EAAKGGHTSVVCYLLD 718
Score = 83.6 bits (205), Expect = 5e-16
Identities = 97/373 (26%), Positives = 154/373 (41%), Gaps = 37/373 (9%)
Query: 89 QQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETP- 147
Q LE +L+A+ + + T DG+ V L +V L++ T+ T
Sbjct: 172 QARLEALLEAA--GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTAN 229
Query: 148 --------LLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKH 199
L A +G + V L+ S+++ + S + A G ++ +LL
Sbjct: 230 AGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM 289
Query: 200 GGNVHLRDGFG-VTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDC 258
NV R G +TPL AA GH +++ L+ DV A + G + L A GG D
Sbjct: 290 HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDV 349
Query: 259 ISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIP-----VTSKNAIRKSGLTPIH 313
+ +LLE G S N GH P+ A GH + L+ T N ++S LT
Sbjct: 350 VKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT--- 406
Query: 314 SAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAG 373
A + + + L+E G D + DE TAL + V +LL +G
Sbjct: 407 LACYKGHLEMVRFLLEAGAD---------QEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
Query: 374 ADPNLDP---LNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYAL-NDE 429
A N+ + L +A + E+ LL+ GA++ VND + +++ A E
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLE----EVNDEGYTPLMEAAREGHE 513
Query: 430 VMLRLLLNNGYQV 442
M+ LLL G +
Sbjct: 514 EMVALLLGQGANI 526
Score = 81.6 bits (200), Expect = 2e-15
Identities = 117/501 (23%), Positives = 188/501 (37%), Gaps = 100/501 (19%)
Query: 38 VPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVL- 96
+P + L A GH+ ++ +++E +++G+ PL EA + ++++ ++L
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG 521
Query: 97 ---------DASYKTLWEFKTCDG-------------------ETPLTLAVKAGLVENVR 128
+ + +T C G TPL A + G +E V+
Sbjct: 522 QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVK 581
Query: 129 TLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQG 188
LL G + G+T L A + G D+ L++ L+ + + +AA+ G
Sbjct: 582 YLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 641
Query: 189 RKDIVALLLKHGGNVHLRDGFGV-TPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVL 247
V L+ G NV+ T L +A GH V+E L+ G D DG+++L
Sbjct: 642 HVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 701
Query: 248 FEAAGGGNPDCISLLLEY----------------------GGSGNVP------------- 272
EAA GG+ + LL+Y + VP
Sbjct: 702 IEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEP 761
Query: 273 -----NRAGHLPIHRAAYEG----------HYLALKYLIPVTSKNA--IRKSGLTPIHSA 315
N A LPI A G H +A P T + I S + PI+ A
Sbjct: 762 DKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPA 821
Query: 316 AD------GQNAQCLELLIENGFD--VNTLLADHISQSYDDERK-TALYFGVSNNDVHCT 366
D + L L G + V TLL S + D++ T L + V
Sbjct: 822 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 881
Query: 367 EVLLAAGADPNLDPLNC----LLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVI 422
E+LL GAD L +A E+V LLL+ GAN H N + + +
Sbjct: 882 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE----HRNVSDYTPLS 937
Query: 423 QYALNDEV-MLRLLLNNGYQV 442
A V ++++LLN G ++
Sbjct: 938 LAASGGYVNIIKILLNAGAEI 958
Score = 74.3 bits (181), Expect = 3e-13
Identities = 67/256 (26%), Positives = 108/256 (42%), Gaps = 40/256 (15%)
Query: 79 PLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPN 138
PL A Q+++E++L E + TPL+LA G V ++ LL G N
Sbjct: 902 PLSLACSGGRQEVVELLLARGANK--EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 959
Query: 139 TKNDK--GETPLLIAVKKGSYDMVSTLIKHNTSLD-QPCVKRWSAMHEAAKQGRKDIVAL 195
++ G +PL++A G V L+ + ++ Q R +A+ A QGR ++V+L
Sbjct: 960 SRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSL 1019
Query: 196 LLKHGGNVHLRDGFGVTPL-----------------------------------GVAAEY 220
LL NV R G+TPL +AA+
Sbjct: 1020 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1079
Query: 221 GHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPI 280
GH E LI +G + G + L+ AA GG+ D + LL++ G + + P+
Sbjct: 1080 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1139
Query: 281 HRAAYEGHYLALKYLI 296
A +GH ++YL+
Sbjct: 1140 MAAFRKGHVKVVRYLV 1155
Score = 62.4 bits (150), Expect = 1e-09
Identities = 54/191 (28%), Positives = 89/191 (46%), Gaps = 3/191 (1%)
Query: 76 GWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGV 135
G PL A + ++++LD + +T + T LTLA G E V LL++
Sbjct: 967 GISPLMLAAMNGHTAAVKLLLDMGSDINAQIET-NRNTALTLACFQGRTEVVSLLLDRKA 1025
Query: 136 WPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCV--KRWSAMHEAAKQGRKDIV 193
+ G TPL+ A G ++ L+ ++ P V R +A+ AA +G
Sbjct: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
LL+ G ++ +R+ G TPL +AA GH DV++ L+ G DV A + + L A
Sbjct: 1086 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRK 1145
Query: 254 GNPDCISLLLE 264
G+ + L++
Sbjct: 1146 GHVKVVRYLVK 1156
Score = 50.1 bits (118), Expect = 6e-06
Identities = 37/156 (23%), Positives = 67/156 (42%)
Query: 43 QNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKT 102
+N L A QG + + K ++ + G PL EA ++ ++LD
Sbjct: 1001 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1060
Query: 103 LWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVST 162
+T LT+A G + L+ +G + +N KG TPL +A G D+V
Sbjct: 1061 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120
Query: 163 LIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLK 198
L++ +D ++ + + A ++G +V L+K
Sbjct: 1121 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 107 bits (268), Expect = 2e-23
Identities = 91/333 (27%), Positives = 151/333 (45%), Gaps = 15/333 (4%)
Query: 79 PLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPN 138
PLH V Q + + ++L +++ + +T G TPL +A + + LL G N
Sbjct: 365 PLHFLVAQGSVEQVRLLL--AHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 139 TKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLK 198
++ G PL A + G L+ H +D + W+ +H AA+ +++ LL+
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482
Query: 199 HGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDC 258
+ +L + G TPL VAA +GH +++ L +G ++ A + + L A G
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542
Query: 259 ISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAAD 317
I LL+ G + +++G+ P+H AA G YL K L+ S G TP+H AA
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602
Query: 318 GQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPN 377
+ + + LL E+ ++ L A T L+ + + LL GADPN
Sbjct: 603 KGHLEIIHLLAESHANMGALGA---------VNWTPLHLAARHGEEAVVSALLQCGADPN 653
Query: 378 L---DPLNCLLVAVRANNYEIVRLLLSHGANVN 407
L +AV+ + + V LL H ANV+
Sbjct: 654 AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH 686
Score = 105 bits (261), Expect = 2e-22
Identities = 74/264 (28%), Positives = 124/264 (46%), Gaps = 3/264 (1%)
Query: 69 MDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVR 128
+D + +GW PLH A + + +++ +G+TPL +A G V V+
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADP--NLHEAEGKTPLHVAAYFGHVSLVK 511
Query: 129 TLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQG 188
L +G + + TPL +AV++G + L+K D + +H AA +G
Sbjct: 512 LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARG 571
Query: 189 RKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLF 248
+ I +LL++G ++ L G TPL +AA GH +++ L ++ AL + L
Sbjct: 572 KYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLH 631
Query: 249 EAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-NAIRKS 307
AA G +S LL+ G N ++G P+H A +L++ L+ + +A K
Sbjct: 632 LAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKV 691
Query: 308 GLTPIHSAADGQNAQCLELLIENG 331
G TP H AA N L++L+E G
Sbjct: 692 GWTPAHLAALKGNTAILKVLVEAG 715
Score = 71.2 bits (173), Expect = 2e-12
Identities = 48/177 (27%), Positives = 87/177 (49%), Gaps = 2/177 (1%)
Query: 63 VKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAG 122
++Y +++ +GW PLH A + +I+ ++ + S+ + + TPL LA + G
Sbjct: 580 LRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAE-SHANMGALGAVNW-TPLHLAARHG 637
Query: 123 LVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMH 182
V LL+ G PN G TPL +AV++ ++ V L++H+ ++ W+ H
Sbjct: 638 EEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAH 697
Query: 183 EAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLAL 239
AA +G I+ +L++ G + ++DG TPL +A ++ L K V L
Sbjct: 698 LAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATL 754
Score = 55.1 bits (131), Expect = 2e-07
Identities = 53/198 (26%), Positives = 78/198 (39%), Gaps = 13/198 (6%)
Query: 211 VTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGN 270
VTPL G + + L+ DV G + L AA PD +LLL +G N
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 271 VPNRAGHLPIHRAAYEGHYLALKYLIP-VTSKNAIRKSGLTPIHSAADGQNAQCLELLIE 329
+ G P+H AA G + L+ +A + G TP+H AA LL+
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482
Query: 330 NGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNC---LLV 386
D N ++ E KT L+ V ++L + GA+ + N L +
Sbjct: 483 RQADPNL---------HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533
Query: 387 AVRANNYEIVRLLLSHGA 404
AV ++ LL GA
Sbjct: 534 AVERGKVRAIQHLLKSGA 551
Score = 32.7 bits (73), Expect = 0.96
Identities = 32/118 (27%), Positives = 49/118 (41%), Gaps = 12/118 (10%)
Query: 293 KYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKT 352
K L+P + I ++ +TP+H + + + LL+ + DV+ A T
Sbjct: 347 KNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGY---------T 397
Query: 353 ALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGANVN 407
L + +LLA GAD N D L A + + RLLL HGA V+
Sbjct: 398 PLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVD 455
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 105 bits (263), Expect = 9e-23
Identities = 91/303 (30%), Positives = 142/303 (46%), Gaps = 16/303 (5%)
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNT-KNDKGETPLLIAVKKGSYDMVSTLIKHNT 168
+G TPL A AG VE R LL+ G NT N+ E+ L +A KG DMV L++
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396
Query: 169 SLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEH 228
+ + +A+ EA G ++ LLL G V++ +PL +AA GH ++
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 229 LIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV-PNRAGHLPIHRAAYEG 287
LI +G ++ + D+G + L EAA G+ + ++LLL G + N + A G
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
Query: 288 HYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYD 347
+LI + I TP+ A+ + + ++ L+ +G +V H + +
Sbjct: 517 FSEVADFLIKAGAD--IELGCSTPLMEASQEGHLELVKYLLASGANV------HATTATG 568
Query: 348 DERKTALYFGVSNNDVHCTEVLLAAGADPNLDP---LNCLLVAVRANNYEIVRLLLSHGA 404
D TAL + N +VLL AGAD + L+ A RA + V+ L+S GA
Sbjct: 569 D---TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGA 625
Query: 405 NVN 407
NVN
Sbjct: 626 NVN 628
Score = 100 bits (250), Expect = 3e-21
Identities = 92/336 (27%), Positives = 143/336 (42%), Gaps = 44/336 (13%)
Query: 108 TCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGE-TPLLIAVKKGSYDMVSTLIKH 166
T +GE+ L LA AG E + LL + +KG+ TPL+ A G D+V L+ H
Sbjct: 235 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLH 294
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV- 225
+ ++ +A+ A G DIV +LL G N+ + G TPL AA GH +V
Sbjct: 295 DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 354
Query: 226 ---LEH------------------------------LIHKGGDVLALADDGASVLFEAAG 252
L+H L+ G D D+ + L EA
Sbjct: 355 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414
Query: 253 GGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY-LALKYLIPVTSKNAIRKSGLTP 311
G+ + LLL+ G N+P + P+ AA GH LA + + + G TP
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
Query: 312 IHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLA 371
+ AA + + + LL+ G ++N ++ ++TAL + L+
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINA--------QTEETQETALTLACCGGFSEVADFLIK 526
Query: 372 AGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
AGAD L L+ A + + E+V+ LL+ GANV+
Sbjct: 527 AGADIELGCSTPLMEASQEGHLELVKYLLASGANVH 562
Score = 95.9 bits (237), Expect = 9e-20
Identities = 85/308 (27%), Positives = 139/308 (45%), Gaps = 18/308 (5%)
Query: 105 EFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLI 164
E KT + T L A G VE R LL+ G N D E+PL +A G ++ + LI
Sbjct: 399 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 458
Query: 165 KHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLR-DGFGVTPLGVAAEYGHC 223
+ +L++ + ++ + EAA++G +++VALLL G N++ + + T L +A G
Sbjct: 459 ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFS 518
Query: 224 DVLEHLIHKGGDVLALADDGASV-LFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHR 282
+V + LI G D+ + G S L EA+ G+ + + LL G + + G +
Sbjct: 519 EVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTY 574
Query: 283 AAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADH 341
A GH L+ + G TP+ AA + ++ LI G +VN A++
Sbjct: 575 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634
Query: 342 ISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPN---LDPLNCLLVAVRANNYEIVRL 398
T + + + E+LLA GADP D L+ A + + +V
Sbjct: 635 --------DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSY 686
Query: 399 LLSHGANV 406
LL + NV
Sbjct: 687 LLDYPNNV 694
Score = 95.5 bits (236), Expect = 1e-19
Identities = 102/426 (23%), Positives = 183/426 (42%), Gaps = 31/426 (7%)
Query: 8 DEDHLTSYDIQLSIQESIEASKTALCPERFVPLSAQNRKL--VEAIKQGHIPELQEYVKY 65
DED ++ + + QE ++ E F+ +A+ L V+ Q + L E
Sbjct: 96 DEDEVSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGI 155
Query: 66 KYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETP-------LTLA 118
+ AD K + V++ + + LD + L K + L A
Sbjct: 156 G-KLSTADGKAF--ADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEA 212
Query: 119 VKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVK-R 177
G V VR LL++G N ++GE+ L +A G Y++ L+ + +++ K
Sbjct: 213 CSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
Query: 178 WSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVL 237
+ + A+ G DIV LLL H +V+ + G T L A G D+++ L+++G ++
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 238 ALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV-PNRAGHLPIHRAAYEGHYLALKYLI 296
++G + L EAA G+ + +LL++G N N + A Y+GH +++L+
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 297 PVTSKNAIRKSGL-TPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALY 355
+ + + T + A + + LL+++G VN D ++ L
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---------DSFESPLT 443
Query: 356 FGVSNNDVHCTEVLLAAGADPNLDPLN-----CLLVAVRANNYEIVRLLLSHGANVNCYF 410
V +L+ GA NL+ +N L+ A R + E+V LLL+ GAN+N
Sbjct: 444 LAACGGHVELAALLIERGA--NLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 411 MHVNDT 416
+T
Sbjct: 502 EETQET 507
Score = 84.0 bits (206), Expect = 4e-16
Identities = 84/303 (27%), Positives = 138/303 (45%), Gaps = 11/303 (3%)
Query: 41 SAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASY 100
S + L A GH + + ++ D+KG+ PL A ++EI+LD
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112
Query: 101 KTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMV 160
+ + +TPL+LA G E V LL +G +N TPL +A G +++
Sbjct: 1113 DIEAQSERTK-DTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 161 STLIKHNTSLDQPCVKRW--SAMHEAAKQGRKDIVALLLKHGGNVHLR-DGFGVTPLGVA 217
L+ ++ + S + AA G V LLL G +++ + + T L +A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
Query: 218 AEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVP----N 273
G +V+ L+ + +V A G + L EAA GG + +LL+ G N P +
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
Query: 274 RAGHLPIHRAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADGQNAQCLELLIENGF 332
R L I AA +GHY + LI + +R K G TP+ A++G + ++LL++ G
Sbjct: 1292 RDTALTI--AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 333 DVN 335
DV+
Sbjct: 1350 DVD 1352
Score = 81.6 bits (200), Expect = 2e-15
Identities = 67/236 (28%), Positives = 110/236 (46%), Gaps = 15/236 (6%)
Query: 179 SAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLA 238
+A+ A G +++V++L+ + RD G TPL +AA GH V+E L+ KGGD+ A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 239 LADDGASV-LFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIP 297
++ L A GG + + LLL G + N + + P+ AA G+ +K L+
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 298 VTSKNAIR---KSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTAL 354
++ R K G++P+ AA + ++LL++ G D+N + + R TAL
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI--------ETNRNTAL 1228
Query: 355 YFGVSNNDVHCTEVLLAAGADPN---LDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
+LL A+ L L+ A E+ R+LL GA+VN
Sbjct: 1229 TLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Score = 75.9 bits (185), Expect = 1e-13
Identities = 66/256 (25%), Positives = 109/256 (42%), Gaps = 40/256 (15%)
Query: 79 PLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPN 138
PL A Q++++++L E + TPL+LA G V ++ LL G N
Sbjct: 1125 PLSLACSGGRQEVVDLLLARGANK--EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1182
Query: 139 TKNDK--GETPLLIAVKKGSYDMVSTLIKHNTSLD-QPCVKRWSAMHEAAKQGRKDIVAL 195
++ G +PL++A G V L+ + ++ Q R +A+ A QGR ++V+L
Sbjct: 1183 SRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSL 1242
Query: 196 LLKHGGNVHLRDGFGVTPL-----------------------------------GVAAEY 220
LL NV R G+TPL +AA+
Sbjct: 1243 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
Query: 221 GHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPI 280
GH E LIH+G + G + L+ A+ GG+ D + LL++ G + + P+
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
Query: 281 HRAAYEGHYLALKYLI 296
A +GH ++YL+
Sbjct: 1363 MSAFRKGHVKVVQYLV 1378
Score = 61.6 bits (148), Expect = 2e-09
Identities = 53/191 (27%), Positives = 89/191 (46%), Gaps = 3/191 (1%)
Query: 76 GWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGV 135
G PL A + ++++LD + +T + T LTLA G E V LL++
Sbjct: 1190 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIET-NRNTALTLACFQGRAEVVSLLLDRKA 1248
Query: 136 WPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCV--KRWSAMHEAAKQGRKDIV 193
+ G TPL+ A G ++ L+ ++ P V R +A+ AA +G
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
LL+ G ++ +R+ G TPL +A+ GH DV++ L+ G DV A + + L A
Sbjct: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
Query: 254 GNPDCISLLLE 264
G+ + L++
Sbjct: 1369 GHVKVVQYLVK 1379
Score = 52.8 bits (125), Expect = 9e-07
Identities = 41/141 (29%), Positives = 66/141 (46%), Gaps = 1/141 (0%)
Query: 108 TCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHN 167
T G+T LT A + G + LL+ G +++ G TPL+ A + G V LI
Sbjct: 565 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG 624
Query: 168 TSLDQPCVKR-WSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
++++ + + A G +V LLL HG + R G T L AA+ GH +V+
Sbjct: 625 ANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVV 684
Query: 227 EHLIHKGGDVLALADDGASVL 247
+L+ +VL++ S L
Sbjct: 685 SYLLDYPNNVLSVPTTDVSQL 705
Score = 52.0 bits (123), Expect = 2e-06
Identities = 37/156 (23%), Positives = 68/156 (43%)
Query: 43 QNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKT 102
+N L A QG + + K ++ + G PL EA ++ ++LD
Sbjct: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Query: 103 LWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVST 162
+T LT+A G + L+ +G + +N KG TPL +A G +D+V
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
Query: 163 LIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLK 198
L++ +D ++ + + A ++G +V L+K
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 105 bits (263), Expect = 9e-23
Identities = 91/303 (30%), Positives = 142/303 (46%), Gaps = 16/303 (5%)
Query: 110 DGETPLTLAVKAGLVENVRTLLEKGVWPNT-KNDKGETPLLIAVKKGSYDMVSTLIKHNT 168
+G TPL A AG VE R LL+ G NT N+ E+ L +A KG DMV L++
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396
Query: 169 SLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEH 228
+ + +A+ EA G ++ LLL G V++ +PL +AA GH ++
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
Query: 229 LIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV-PNRAGHLPIHRAAYEG 287
LI +G ++ + D+G + L EAA G+ + ++LLL G + N + A G
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
Query: 288 HYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYD 347
+LI + I TP+ A+ + + ++ L+ +G +V H + +
Sbjct: 517 FSEVADFLIKAGAD--IELGCSTPLMEASQEGHLELVKYLLASGANV------HATTATG 568
Query: 348 DERKTALYFGVSNNDVHCTEVLLAAGADPNLDP---LNCLLVAVRANNYEIVRLLLSHGA 404
D TAL + N +VLL AGAD + L+ A RA + V+ L+S GA
Sbjct: 569 D---TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGA 625
Query: 405 NVN 407
NVN
Sbjct: 626 NVN 628
Score = 100 bits (250), Expect = 3e-21
Identities = 92/336 (27%), Positives = 143/336 (42%), Gaps = 44/336 (13%)
Query: 108 TCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGE-TPLLIAVKKGSYDMVSTLIKH 166
T +GE+ L LA AG E + LL + +KG+ TPL+ A G D+V L+ H
Sbjct: 235 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLH 294
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV- 225
+ ++ +A+ A G DIV +LL G N+ + G TPL AA GH +V
Sbjct: 295 DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 354
Query: 226 ---LEH------------------------------LIHKGGDVLALADDGASVLFEAAG 252
L+H L+ G D D+ + L EA
Sbjct: 355 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414
Query: 253 GGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY-LALKYLIPVTSKNAIRKSGLTP 311
G+ + LLL+ G N+P + P+ AA GH LA + + + G TP
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
Query: 312 IHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLA 371
+ AA + + + LL+ G ++N ++ ++TAL + L+
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINA--------QTEETQETALTLACCGGFSEVADFLIK 526
Query: 372 AGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
AGAD L L+ A + + E+V+ LL+ GANV+
Sbjct: 527 AGADIELGCSTPLMEASQEGHLELVKYLLASGANVH 562
Score = 95.9 bits (237), Expect = 9e-20
Identities = 85/308 (27%), Positives = 139/308 (45%), Gaps = 18/308 (5%)
Query: 105 EFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLI 164
E KT + T L A G VE R LL+ G N D E+PL +A G ++ + LI
Sbjct: 399 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 458
Query: 165 KHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLR-DGFGVTPLGVAAEYGHC 223
+ +L++ + ++ + EAA++G +++VALLL G N++ + + T L +A G
Sbjct: 459 ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFS 518
Query: 224 DVLEHLIHKGGDVLALADDGASV-LFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHR 282
+V + LI G D+ + G S L EA+ G+ + + LL G + + G +
Sbjct: 519 EVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTY 574
Query: 283 AAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADH 341
A GH L+ + G TP+ AA + ++ LI G +VN A++
Sbjct: 575 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634
Query: 342 ISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPN---LDPLNCLLVAVRANNYEIVRL 398
T + + + E+LLA GADP D L+ A + + +V
Sbjct: 635 --------DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSY 686
Query: 399 LLSHGANV 406
LL + NV
Sbjct: 687 LLDYPNNV 694
Score = 95.5 bits (236), Expect = 1e-19
Identities = 102/426 (23%), Positives = 183/426 (42%), Gaps = 31/426 (7%)
Query: 8 DEDHLTSYDIQLSIQESIEASKTALCPERFVPLSAQNRKL--VEAIKQGHIPELQEYVKY 65
DED ++ + + QE ++ E F+ +A+ L V+ Q + L E
Sbjct: 96 DEDEVSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGI 155
Query: 66 KYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETP-------LTLA 118
+ AD K + V++ + + LD + L K + L A
Sbjct: 156 G-KLSTADGKAF--ADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEA 212
Query: 119 VKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVK-R 177
G V VR LL++G N ++GE+ L +A G Y++ L+ + +++ K
Sbjct: 213 CSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
Query: 178 WSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVL 237
+ + A+ G DIV LLL H +V+ + G T L A G D+++ L+++G ++
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
Query: 238 ALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV-PNRAGHLPIHRAAYEGHYLALKYLI 296
++G + L EAA G+ + +LL++G N N + A Y+GH +++L+
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 297 PVTSKNAIRKSGL-TPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALY 355
+ + + T + A + + LL+++G VN D ++ L
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---------DSFESPLT 443
Query: 356 FGVSNNDVHCTEVLLAAGADPNLDPLN-----CLLVAVRANNYEIVRLLLSHGANVNCYF 410
V +L+ GA NL+ +N L+ A R + E+V LLL+ GAN+N
Sbjct: 444 LAACGGHVELAALLIERGA--NLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 411 MHVNDT 416
+T
Sbjct: 502 EETQET 507
Score = 84.0 bits (206), Expect = 4e-16
Identities = 84/303 (27%), Positives = 138/303 (45%), Gaps = 11/303 (3%)
Query: 41 SAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASY 100
S + L A GH + + ++ D+KG+ PL A ++EI+LD
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112
Query: 101 KTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMV 160
+ + +TPL+LA G E V LL +G +N TPL +A G +++
Sbjct: 1113 DIEAQSERTK-DTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 161 STLIKHNTSLDQPCVKRW--SAMHEAAKQGRKDIVALLLKHGGNVHLR-DGFGVTPLGVA 217
L+ ++ + S + AA G V LLL G +++ + + T L +A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
Query: 218 AEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVP----N 273
G +V+ L+ + +V A G + L EAA GG + +LL+ G N P +
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
Query: 274 RAGHLPIHRAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADGQNAQCLELLIENGF 332
R L I AA +GHY + LI + +R K G TP+ A++G + ++LL++ G
Sbjct: 1292 RDTALTI--AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 333 DVN 335
DV+
Sbjct: 1350 DVD 1352
Score = 81.6 bits (200), Expect = 2e-15
Identities = 67/236 (28%), Positives = 110/236 (46%), Gaps = 15/236 (6%)
Query: 179 SAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLA 238
+A+ A G +++V++L+ + RD G TPL +AA GH V+E L+ KGGD+ A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 239 LADDGASV-LFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIP 297
++ L A GG + + LLL G + N + + P+ AA G+ +K L+
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 298 VTSKNAIR---KSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTAL 354
++ R K G++P+ AA + ++LL++ G D+N + + R TAL
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI--------ETNRNTAL 1228
Query: 355 YFGVSNNDVHCTEVLLAAGADPN---LDPLNCLLVAVRANNYEIVRLLLSHGANVN 407
+LL A+ L L+ A E+ R+LL GA+VN
Sbjct: 1229 TLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Score = 75.9 bits (185), Expect = 1e-13
Identities = 66/256 (25%), Positives = 109/256 (42%), Gaps = 40/256 (15%)
Query: 79 PLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPN 138
PL A Q++++++L E + TPL+LA G V ++ LL G N
Sbjct: 1125 PLSLACSGGRQEVVDLLLARGANK--EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1182
Query: 139 TKNDK--GETPLLIAVKKGSYDMVSTLIKHNTSLD-QPCVKRWSAMHEAAKQGRKDIVAL 195
++ G +PL++A G V L+ + ++ Q R +A+ A QGR ++V+L
Sbjct: 1183 SRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSL 1242
Query: 196 LLKHGGNVHLRDGFGVTPL-----------------------------------GVAAEY 220
LL NV R G+TPL +AA+
Sbjct: 1243 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
Query: 221 GHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPI 280
GH E LIH+G + G + L+ A+ GG+ D + LL++ G + + P+
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
Query: 281 HRAAYEGHYLALKYLI 296
A +GH ++YL+
Sbjct: 1363 MSAFRKGHVKVVQYLV 1378
Score = 61.6 bits (148), Expect = 2e-09
Identities = 53/191 (27%), Positives = 89/191 (46%), Gaps = 3/191 (1%)
Query: 76 GWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGV 135
G PL A + ++++LD + +T + T LTLA G E V LL++
Sbjct: 1190 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIET-NRNTALTLACFQGRAEVVSLLLDRKA 1248
Query: 136 WPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCV--KRWSAMHEAAKQGRKDIV 193
+ G TPL+ A G ++ L+ ++ P V R +A+ AA +G
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
Query: 194 ALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGG 253
LL+ G ++ +R+ G TPL +A+ GH DV++ L+ G DV A + + L A
Sbjct: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
Query: 254 GNPDCISLLLE 264
G+ + L++
Sbjct: 1369 GHVKVVQYLVK 1379
Score = 52.8 bits (125), Expect = 9e-07
Identities = 41/141 (29%), Positives = 66/141 (46%), Gaps = 1/141 (0%)
Query: 108 TCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHN 167
T G+T LT A + G + LL+ G +++ G TPL+ A + G V LI
Sbjct: 565 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG 624
Query: 168 TSLDQPCVKR-WSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
++++ + + A G +V LLL HG + R G T L AA+ GH +V+
Sbjct: 625 ANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVV 684
Query: 227 EHLIHKGGDVLALADDGASVL 247
+L+ +VL++ S L
Sbjct: 685 SYLLDYPNNVLSVPTTDVSQL 705
Score = 52.0 bits (123), Expect = 2e-06
Identities = 37/156 (23%), Positives = 68/156 (43%)
Query: 43 QNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKT 102
+N L A QG + + K ++ + G PL EA ++ ++LD
Sbjct: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Query: 103 LWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVST 162
+T LT+A G + L+ +G + +N KG TPL +A G +D+V
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
Query: 163 LIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLK 198
L++ +D ++ + + A ++G +V L+K
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 105 bits (263), Expect = 9e-23
Identities = 94/305 (30%), Positives = 138/305 (45%), Gaps = 34/305 (11%)
Query: 112 ETPLT----LAVKAGLVENVRTLLEKG-VWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
ETPL A + G + ++ LL G V + ++ G T L++A G D V L+
Sbjct: 9 ETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQ 68
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
++ +A+ AA+QG D+V L G + R G T L A++YGH V+
Sbjct: 69 GADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVV 128
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE 286
E L+ G ++ DGA+ LF AA GG D I LLL G N P + G P+ A+
Sbjct: 129 ETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQM 188
Query: 287 GHYLALK-YLIPVTSKNAIRKSGLTPIHSAAD-GQNAQCLELL--------IENGFDVNT 336
GH ++ L+ ++A R G T + AA+ G N ELL ++NG
Sbjct: 189 GHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNG----- 243
Query: 337 LLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIV 396
+AL+ V + ++ +LL AGADP+L L A N I+
Sbjct: 244 --------------TSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERIL 289
Query: 397 RLLLS 401
RLL S
Sbjct: 290 RLLRS 294
Score = 99.0 bits (245), Expect = 1e-20
Identities = 66/223 (29%), Positives = 112/223 (50%)
Query: 111 GETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSL 170
G T L +A AG ++ VR L+ +G N + + G T L A ++G D+V L S
Sbjct: 46 GTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGAST 105
Query: 171 DQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 230
+ +A+ A++ G +V LLKHG N+H + G T L +AA+ G+ DV+ L+
Sbjct: 106 EFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLL 165
Query: 231 HKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYL 290
G V DG + L+ A+ G+ + + ++L G + G + +AA +G+
Sbjct: 166 ASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYND 225
Query: 291 ALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFD 333
+K L+ + I K+G + +H+A N + + LL+E G D
Sbjct: 226 VIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGAD 268
Score = 85.9 bits (211), Expect = 1e-16
Identities = 74/261 (28%), Positives = 118/261 (45%), Gaps = 9/261 (3%)
Query: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
L+ A GHI ++E V ++ E G L A Q ++ + T EF
Sbjct: 50 LMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGAST--EF 107
Query: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
+T DG T L A + G ++ V TLL+ G + + G T L +A + G D++ L+
Sbjct: 108 RTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLAS 167
Query: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
++QP + + A++ G ++V ++L G + G T L AA G+ DV+
Sbjct: 168 GAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVI 227
Query: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE 286
+ L+ K L + +G S L A GN ++LLLE G ++ N+A LP E
Sbjct: 228 KELL-KFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNE 286
Query: 287 GHYLALKYLIPVTSKNAIRKS 307
+ L + SK RKS
Sbjct: 287 ------RILRLLRSKEGPRKS 301
Score = 63.9 bits (154), Expect = 4e-10
Identities = 54/194 (27%), Positives = 94/194 (48%), Gaps = 14/194 (7%)
Query: 217 AAEYGHCDVLEHLIHKGG-DVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRA 275
AA G+ +L+ L++ G DV G ++L AA G+ DC+ L+ G N+ +
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
Query: 276 GHLPIHRAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADGQNAQCLELLIENGFDV 334
G + AA +GH +++L + R K G T + +A+ + Q +E L+++G ++
Sbjct: 79 GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
Query: 335 NTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGA---DPNLDPLNCLLVAVRAN 391
+ Q YD TAL+ + +LLA+GA P D L +A +
Sbjct: 139 H-------DQLYDGA--TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMG 189
Query: 392 NYEIVRLLLSHGAN 405
+ E+VR++L GA+
Sbjct: 190 HSEVVRVMLLRGAD 203
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,570,589
Number of Sequences: 37866
Number of extensions: 1014714
Number of successful extensions: 6721
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 334
Number of HSP's successfully gapped in prelim test: 54
Number of HSP's that attempted gapping in prelim test: 2034
Number of HSP's gapped (non-prelim): 2043
length of query: 588
length of database: 18,247,518
effective HSP length: 108
effective length of query: 480
effective length of database: 14,157,990
effective search space: 6795835200
effective search space used: 6795835200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.