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Search of human proteins with 90652855
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|90652855 EF-hand calcium binding domain 5 isoform a [Homo
sapiens]
(1503 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|90652855 EF-hand calcium binding domain 5 isoform a [Homo sap... 3002 0.0
gi|223029500 EF-hand calcium binding domain 5 isoform b [Homo sa... 1601 0.0
gi|221219020 NYD-SP11 protein [Homo sapiens] 57 2e-07
gi|55770834 centromere protein F [Homo sapiens] 55 4e-07
gi|56676335 RAP1 interacting factor 1 [Homo sapiens] 49 3e-05
gi|71061468 centromere protein E [Homo sapiens] 49 5e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 49 5e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 49 5e-05
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 49 5e-05
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 49 5e-05
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 49 5e-05
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 49 5e-05
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 49 5e-05
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 49 5e-05
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 48 8e-05
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 47 1e-04
gi|222537747 hypothetical protein LOC342979 [Homo sapiens] 46 2e-04
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 46 2e-04
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 46 2e-04
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 45 4e-04
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 45 4e-04
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 45 4e-04
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 45 4e-04
gi|7706635 cornulin [Homo sapiens] 45 5e-04
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 45 7e-04
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 44 0.001
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 44 0.001
gi|21328446 hormone-sensitive lipase [Homo sapiens] 44 0.001
gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Hom... 43 0.002
gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Hom... 43 0.002
>gi|90652855 EF-hand calcium binding domain 5 isoform a [Homo sapiens]
Length = 1503
Score = 3002 bits (7783), Expect = 0.0
Identities = 1503/1503 (100%), Positives = 1503/1503 (100%)
Query: 1 MNESASQEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEI 60
MNESASQEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEI
Sbjct: 1 MNESASQEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEI 60
Query: 61 KSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLFE 120
KSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLFE
Sbjct: 61 KSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLFE 120
Query: 121 RMEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTAYLLDKLLP 180
RMEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTAYLLDKLLP
Sbjct: 121 RMEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTAYLLDKLLP 180
Query: 181 TLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNYIKDPGMSGYQRLMKE 240
TLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNYIKDPGMSGYQRLMKE
Sbjct: 181 TLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNYIKDPGMSGYQRLMKE 240
Query: 241 VTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKVANTRKQALQEQFDEWILDP 300
VTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKVANTRKQALQEQFDEWILDP
Sbjct: 241 VTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKVANTRKQALQEQFDEWILDP 300
Query: 301 KGMIPKSVIQNVLQEFFQNPDFKLGSHCKQLDITDSTEPRLNKMEFTEYISSHIKDLKSE 360
KGMIPKSVIQNVLQEFFQNPDFKLGSHCKQLDITDSTEPRLNKMEFTEYISSHIKDLKSE
Sbjct: 301 KGMIPKSVIQNVLQEFFQNPDFKLGSHCKQLDITDSTEPRLNKMEFTEYISSHIKDLKSE 360
Query: 361 MFEELLKHLCHSADEFREVIKADMRRQMFAELFLHCDHGKVGFLDRQRTLALLELFYDHS 420
MFEELLKHLCHSADEFREVIKADMRRQMFAELFLHCDHGKVGFLDRQRTLALLELFYDHS
Sbjct: 361 MFEELLKHLCHSADEFREVIKADMRRQMFAELFLHCDHGKVGFLDRQRTLALLELFYDHS 420
Query: 421 SQMLRSLLRNPRQWPFIEFEEINLTELWGDMDNQKHIYEGFDKVLLEMNTLLSANHASKT 480
SQMLRSLLRNPRQWPFIEFEEINLTELWGDMDNQKHIYEGFDKVLLEMNTLLSANHASKT
Sbjct: 421 SQMLRSLLRNPRQWPFIEFEEINLTELWGDMDNQKHIYEGFDKVLLEMNTLLSANHASKT 480
Query: 481 QSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQELYI 540
QSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQELYI
Sbjct: 481 QSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQELYI 540
Query: 541 ESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSR 600
ESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSR
Sbjct: 541 ESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSR 600
Query: 601 ESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEII 660
ESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEII
Sbjct: 601 ESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEII 660
Query: 661 SEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
SEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE
Sbjct: 661 SEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
Query: 721 VPTLSRKDHFPETTKKEVQKDKPCEPKSQKIEGKSWSGEFFTCNWKMKYVTFEDEEQANL 780
VPTLSRKDHFPETTKKEVQKDKPCEPKSQKIEGKSWSGEFFTCNWKMKYVTFEDEEQANL
Sbjct: 721 VPTLSRKDHFPETTKKEVQKDKPCEPKSQKIEGKSWSGEFFTCNWKMKYVTFEDEEQANL 780
Query: 781 IYGNSRFTDLHSIIRNIQSCKEVKGRTAFNGVSFNLLQFVQLLETFVGEDAPLSVSETLT 840
IYGNSRFTDLHSIIRNIQSCKEVKGRTAFNGVSFNLLQFVQLLETFVGEDAPLSVSETLT
Sbjct: 781 IYGNSRFTDLHSIIRNIQSCKEVKGRTAFNGVSFNLLQFVQLLETFVGEDAPLSVSETLT 840
Query: 841 SFFKEGYVETEQEKMNALEQFSQNAFQVRQRLLLEAIFQKWDSDGSGFLDLKEVDELLYT 900
SFFKEGYVETEQEKMNALEQFSQNAFQVRQRLLLEAIFQKWDSDGSGFLDLKEVDELLYT
Sbjct: 841 SFFKEGYVETEQEKMNALEQFSQNAFQVRQRLLLEAIFQKWDSDGSGFLDLKEVDELLYT 900
Query: 901 YKEGMEKESMKKAKLHIQFPKPHPGHEVRLSSKQFQNYIELVVSELRGNEDQVLESVVEF 960
YKEGMEKESMKKAKLHIQFPKPHPGHEVRLSSKQFQNYIELVVSELRGNEDQVLESVVEF
Sbjct: 901 YKEGMEKESMKKAKLHIQFPKPHPGHEVRLSSKQFQNYIELVVSELRGNEDQVLESVVEF 960
Query: 961 LMNALERSHIESLRNSARRKWLHQIQCAAETSGVSLEPVYSETFKALMQDAEAHGNKKIS 1020
LMNALERSHIESLRNSARRKWLHQIQCAAETSGVSLEPVYSETFKALMQDAEAHGNKKIS
Sbjct: 961 LMNALERSHIESLRNSARRKWLHQIQCAAETSGVSLEPVYSETFKALMQDAEAHGNKKIS 1020
Query: 1021 AHISLLEENLLLPEKGNVLLRNVACTLDDAQFVLNRVLYRDMKGISFTVVDEGKPIHVPQ 1080
AHISLLEENLLLPEKGNVLLRNVACTLDDAQFVLNRVLYRDMKGISFTVVDEGKPIHVPQ
Sbjct: 1021 AHISLLEENLLLPEKGNVLLRNVACTLDDAQFVLNRVLYRDMKGISFTVVDEGKPIHVPQ 1080
Query: 1081 VQYHGNIFFWNQSRNKHDYNGSFLALPLQDAYMRIFGVLAVDTLRDPHEINIFLPHEIRF 1140
VQYHGNIFFWNQSRNKHDYNGSFLALPLQDAYMRIFGVLAVDTLRDPHEINIFLPHEIRF
Sbjct: 1081 VQYHGNIFFWNQSRNKHDYNGSFLALPLQDAYMRIFGVLAVDTLRDPHEINIFLPHEIRF 1140
Query: 1141 YQGVANVFSTAYHYVHSREHILHIVITGIGWLYDVTSSITSITTYFVEPSPAQDSDYVLR 1200
YQGVANVFSTAYHYVHSREHILHIVITGIGWLYDVTSSITSITTYFVEPSPAQDSDYVLR
Sbjct: 1141 YQGVANVFSTAYHYVHSREHILHIVITGIGWLYDVTSSITSITTYFVEPSPAQDSDYVLR 1200
Query: 1201 NMMVTGQLGLTEIHKNPPTIHRKSCIFRDFLFKCTDSSEVVLASACGETHIVVPLRERTG 1260
NMMVTGQLGLTEIHKNPPTIHRKSCIFRDFLFKCTDSSEVVLASACGETHIVVPLRERTG
Sbjct: 1201 NMMVTGQLGLTEIHKNPPTIHRKSCIFRDFLFKCTDSSEVVLASACGETHIVVPLRERTG 1260
Query: 1261 EALGVLDFNIGQNRMLLCQEYKDLQKMMKVVQVACYEILGEFSGEIKKKYILEIENVREV 1320
EALGVLDFNIGQNRMLLCQEYKDLQKMMKVVQVACYEILGEFSGEIKKKYILEIENVREV
Sbjct: 1261 EALGVLDFNIGQNRMLLCQEYKDLQKMMKVVQVACYEILGEFSGEIKKKYILEIENVREV 1320
Query: 1321 QRAGILFFRIMLLELQESIQLLNSMEFVSLLLYDHTLVTEPNSPQDSKSMELEANVKLVR 1380
QRAGILFFRIMLLELQESIQLLNSMEFVSLLLYDHTLVTEPNSPQDSKSMELEANVKLVR
Sbjct: 1321 QRAGILFFRIMLLELQESIQLLNSMEFVSLLLYDHTLVTEPNSPQDSKSMELEANVKLVR 1380
Query: 1381 DILKAVILFFHPELEFSSDFGSWDKCKFYVNKYLVNNICAFDPTAKHVEVNVQLIDEYIR 1440
DILKAVILFFHPELEFSSDFGSWDKCKFYVNKYLVNNICAFDPTAKHVEVNVQLIDEYIR
Sbjct: 1381 DILKAVILFFHPELEFSSDFGSWDKCKFYVNKYLVNNICAFDPTAKHVEVNVQLIDEYIR 1440
Query: 1441 DHSRTEVWKFGNVVIEHLYHWIHICSALMKITKQLNSGITPPLPSKTDNYMYAKMPGEGL 1500
DHSRTEVWKFGNVVIEHLYHWIHICSALMKITKQLNSGITPPLPSKTDNYMYAKMPGEGL
Sbjct: 1441 DHSRTEVWKFGNVVIEHLYHWIHICSALMKITKQLNSGITPPLPSKTDNYMYAKMPGEGL 1500
Query: 1501 QEK 1503
QEK
Sbjct: 1501 QEK 1503
>gi|223029500 EF-hand calcium binding domain 5 isoform b [Homo
sapiens]
Length = 856
Score = 1601 bits (4146), Expect = 0.0
Identities = 805/806 (99%), Positives = 805/806 (99%)
Query: 57 MDEIKSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKK 116
MDEIKSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKK
Sbjct: 1 MDEIKSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKK 60
Query: 117 NLFERMEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTAYLLD 176
NLFERMEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTAYLLD
Sbjct: 61 NLFERMEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTAYLLD 120
Query: 177 KLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNYIKDPGMSGYQR 236
KLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNYIKDPGMSGYQR
Sbjct: 121 KLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNYIKDPGMSGYQR 180
Query: 237 LMKEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKVANTRKQALQEQFDEW 296
LMKEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKVANTRKQALQEQFDEW
Sbjct: 181 LMKEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKVANTRKQALQEQFDEW 240
Query: 297 ILDPKGMIPKSVIQNVLQEFFQNPDFKLGSHCKQLDITDSTEPRLNKMEFTEYISSHIKD 356
ILDPKGMIPKSVIQNVLQEFFQNPDFKLGSHCKQLDITDSTEPRLNKMEFTEYISSHIKD
Sbjct: 241 ILDPKGMIPKSVIQNVLQEFFQNPDFKLGSHCKQLDITDSTEPRLNKMEFTEYISSHIKD 300
Query: 357 LKSEMFEELLKHLCHSADEFREVIKADMRRQMFAELFLHCDHGKVGFLDRQRTLALLELF 416
LKSEMFEELLKHLCHSADEFREVIKADMRRQMFAELFLHCDHGKVGFLDRQRTLALLELF
Sbjct: 301 LKSEMFEELLKHLCHSADEFREVIKADMRRQMFAELFLHCDHGKVGFLDRQRTLALLELF 360
Query: 417 YDHSSQMLRSLLRNPRQWPFIEFEEINLTELWGDMDNQKHIYEGFDKVLLEMNTLLSANH 476
YDHSSQMLRSLLRNPRQWPFIEFEEINLTELWGDMDNQKHIYEGFDKVLLEMNTLLSANH
Sbjct: 361 YDHSSQMLRSLLRNPRQWPFIEFEEINLTELWGDMDNQKHIYEGFDKVLLEMNTLLSANH 420
Query: 477 ASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQ 536
ASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQ
Sbjct: 421 ASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQ 480
Query: 537 ELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQ 596
ELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQ
Sbjct: 481 ELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQ 540
Query: 597 GSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPY 656
GSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPY
Sbjct: 541 GSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPY 600
Query: 657 GEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSE 716
GEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSE
Sbjct: 601 GEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSE 660
Query: 717 LQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIEGKSWSGEFFTCNWKMKYVTFEDEE 776
LQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIEGKSWSGEFFTCNWKMKYVTFEDEE
Sbjct: 661 LQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIEGKSWSGEFFTCNWKMKYVTFEDEE 720
Query: 777 QANLIYGNSRFTDLHSIIRNIQSCKEVKGRTAFNGVSFNLLQFVQLLETFVGEDAPLSVS 836
QANLIYGNSRFTDLHSIIRNIQSCKEVKGRTAFNGVSFNLLQFVQLLETFVGEDAPLSVS
Sbjct: 721 QANLIYGNSRFTDLHSIIRNIQSCKEVKGRTAFNGVSFNLLQFVQLLETFVGEDAPLSVS 780
Query: 837 ETLTSFFKEGYVETEQEKMNALEQFS 862
ETLTSFFKEGYVETEQEKMNALEQ S
Sbjct: 781 ETLTSFFKEGYVETEQEKMNALEQVS 806
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 56.6 bits (135), Expect = 2e-07
Identities = 156/780 (20%), Positives = 307/780 (39%), Gaps = 122/780 (15%)
Query: 3 ESASQEELRPAQENRKEDKERKWN---------------LTEVKELHETLQSVPDVPVKE 47
E SQE + AQ+ +K K KW L EVK + Q V ++P +E
Sbjct: 1649 EKLSQEAEKLAQKRKKLAK--KWEKVAREEEKLAKKGGKLAEVKNI--LAQKVEELPQRE 1704
Query: 48 DTNSVVEKA-----------MDEI--KSQELNLEGQRKISPGSIKDSKTEASGNIAIRKS 94
EK M+E+ K +ELN E + + K E +A ++
Sbjct: 1705 QNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEE---KKKLAEEEEALAWQRE 1761
Query: 95 AKVIFALDETELKSKPEHTWKKNLFERMEARAQAMQQKIIDKENLKKELEKKAEKKLPRD 154
L E E K E ++ L + E AQ ++ ++E L ++ E+ EKK+
Sbjct: 1762 K-----LSEEETKLAQE---EELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLA 1813
Query: 155 NLAKEWFNTDSMTLNNTAYLLDKLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPINYL 214
+ W N+ N L K L Q +K + + + + Y
Sbjct: 1814 QKRERWINSMEELTKNKMILYQK----------KNLAQEKKNLAQEKEKLAQRKENLLYN 1863
Query: 215 GEYLIRNNPNYIKDPGMSG-YQRLMKEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRES 273
E L + ++ G + +++ +V E L +T+ + K+ E K+ + +S
Sbjct: 1864 KERLTHSKKQLVQVKNKLGMFNKILAQVEEKL-TQEKETVIKKKEKLAETEKKLVQVEDS 1922
Query: 274 IDKIKVKVANTR-KQALQEQFDEWILDPKGMIPKSVIQNVLQ-EFFQNPDFKLGSHCKQL 331
+ K + K+A + K AL++ + +G + + + L E + + K+ +
Sbjct: 1923 LAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKE 1982
Query: 332 DITDSTEPRLNKMEFTEYISSHIKDLKSEMFEELLKHLCHSADEFREVIKADMRRQMFAE 391
++ P ++ + + + K + E++L H + I A M A+
Sbjct: 1983 TLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLH--------EDRILA-MEESEIAK 2033
Query: 392 LFLHCDHGKVGFLDRQRTLALL--ELFYDHSS---------QMLRSLLRNPRQWPFIEFE 440
L G+ F+ QR LA +L S ++L++L + R + E
Sbjct: 2034 GKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQE 2093
Query: 441 EINLTELWGDMDNQKHIYEGFDKVLLEMNTL-LSANHASKTQSKLLESPDQPKLNEQRTS 499
EI +T++ ++ ++ ++ +E + L + S+ +S+L + D+ KL ++
Sbjct: 2094 EIKMTKM------KRALFVKERRLSIEQSKLDIKEWDFSEKRSEL--TKDEKKLARKQRK 2145
Query: 500 TPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSS 559
+ + +R + E ++++ EE + +K E+ ++ E G E +
Sbjct: 2146 LAN----KMRRMINKE---EKMTEEESKLARK---HSEVILDDEEEGGIEEEEVIP---- 2191
Query: 560 RRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRH 619
L + R+ + K Q S ES+ ++ ++ES++ ++
Sbjct: 2192 --FLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEE 2249
Query: 620 KGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSIL 679
+ E+ E+ +RE EE ++ E+G ++ EE+E + +K+ +
Sbjct: 2250 EREEEEE-------REEEEVREE--EEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQ 2300
Query: 680 KSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQ 739
+ E + E E+ + E+ + + EEE S L+EEV D E KKE Q
Sbjct: 2301 EK----EEVFEEKEEI-MSEEETESLSDEEEEEESCSLEEEV------DREKEILKKEKQ 2349
Score = 41.2 bits (95), Expect = 0.008
Identities = 66/321 (20%), Positives = 130/321 (40%), Gaps = 44/321 (13%)
Query: 8 EELRPAQENRKEDKERKW--------NLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDE 59
E+L P +E +EDK+ KW N+ K + + +V ++E+ + E+ +
Sbjct: 1501 EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQ 1560
Query: 60 IKSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLF 119
+ ++ +++ + K + K ++ E RK A+ L + E + E +
Sbjct: 1561 VTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAY 1620
Query: 120 ERMEARAQAMQQ---KIIDK--------ENLKKELEKKAEKKLPRDNLAKEWFNT--DSM 166
++ + M Q K K E L +E EK A+K R LAK+W +
Sbjct: 1621 VKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQK---RKKLAKKWEKVAREEE 1677
Query: 167 TLNNTAYLLDKLLPTLVPGVENMLTQV-----EKKKVLTEADTPS--------KFDPINY 213
L L ++ L VE + + ++K++ E + K + +N
Sbjct: 1678 KLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQ 1737
Query: 214 LGEYLIRNNPNYIKDPGMSGYQR--LMKEVT-----EDLKIYVPDTICNRVSKMKENVKQ 266
L+ ++ +QR L +E T E+L I + + KM E ++
Sbjct: 1738 EEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEER 1797
Query: 267 NRKQRESIDKIKVKVANTRKQ 287
++RE + + K+K+A R++
Sbjct: 1798 LGRKREQLIEKKMKLAQKRER 1818
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 55.5 bits (132), Expect = 4e-07
Identities = 205/1040 (19%), Positives = 386/1040 (37%), Gaps = 173/1040 (16%)
Query: 45 VKEDTNSVVEKAMDEIKSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDET 104
V ED + VE ++E+K + L Q + + + L++
Sbjct: 1789 VIEDRDRKVESLLNEMKELDSKLHLQE-----------------VQLMTKIEACIELEKI 1831
Query: 105 ELKSKPEHTWKKNLFERMEARAQAMQQKIIDKENLKKELEKKAEKKLPRD---NLAK--- 158
+ K E++ E Q + Q++ E L +LE A+K D N+AK
Sbjct: 1832 VGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVND 1891
Query: 159 ---EWF----NTDSMTLNNTAYLLDKLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPI 211
E F N S + A + + L +E L V+ +K+ E D +K I
Sbjct: 1892 SWKERFLDVENELSRIRSEKASIEHEALY-----LEADLEVVQTEKLCLEKDNENKQKVI 1946
Query: 212 NYLGEYL--IRNNPNYI---------KDPGMSGYQRLMKEVTEDLKIYVPDTI-CNRVSK 259
L E L + + N + K + MKE T++L+ + + + C +V++
Sbjct: 1947 VCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAE 2006
Query: 260 MKENVKQNRKQRESIDKIKVKVANTRKQALQEQFDEWILDPKGM-IPKSVIQNVLQEFFQ 318
+ K Q S D ++ T LQE+ D + + + K ++N + + +
Sbjct: 2007 AEVKEKTELLQTLSSDVSELLKDKTH---LQEKLQSLEKDSQALSLTKCELENQIAQLNK 2063
Query: 319 NPDFKLG-SHCKQLDITDSTEPRLNKMEFTE--YISSHIKDLKSEMFEELLKHLCHSADE 375
+ + S Q +++S +LN + E + L+ +E + L ++
Sbjct: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123
Query: 376 FREVIKADMRRQMFA-----------------------ELFLHCDHGKVGFLDRQRTLAL 412
R I+AD ++Q+ EL + ++ ++ LD + + A
Sbjct: 2124 LRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAE 2183
Query: 413 LELFYDHSSQMLRSLLRNPRQWPFIEFEEINLTELWGDMDNQKHIYEGFDKVLLEMNTLL 472
+E +M RSL + E+ NLT+ + Q DK+L +LL
Sbjct: 2184 VETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQ---LSELDKLLSSFKSLL 2240
Query: 473 SANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKP 532
++ Q K L Q E V A G Q I ++ +Q P
Sbjct: 2241 EEKEQAEIQIKEESKTAVEMLQNQLK--------ELNEAVAALCGDQEI-MKATEQSLDP 2291
Query: 533 TAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVS 592
E+E + + IE + LE ++L Q+ +ES KG +E R +
Sbjct: 2292 PIEEEHQLRNSIEK---LRARLEADEKKQLCVLQQL-KESEHHADLLKGRVENL-ERELE 2346
Query: 593 VSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSE 652
++ ++ + S+ E + + +G + S +E++ E ++ E
Sbjct: 2347 IARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQE 2406
Query: 653 QGPYGEIISEEQEDI--------------GSTSQSRKDSILK--------------STKY 684
+ EII+ E+I ST+ + LK + K
Sbjct: 2407 RISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA 2466
Query: 685 GEPITSEYIEVPLQEKRSWEQTYEEE----IFLSS-------ELQEEVPTLSRKDHFPET 733
E S +E EK Q +E I L S E+++ L +KD
Sbjct: 2467 KEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISR 2526
Query: 734 TKKEVQKDKPCEPKSQKIEGKS--WSGEFFTCNWKMKYVTFEDEEQANLIYG-NSRFTD- 789
K ++Q + K ++EG+ W + N +++ +T E E++ ++ N+ D
Sbjct: 2527 LKNQIQDQEQLVSKLSQVEGEHQLWKEQ----NLELRNLTVELEQKIQVLQSKNASLQDT 2582
Query: 790 ---LHSIIRNIQSCKEVKGRTAFNGVSFNLLQFVQLLETFVGEDAPLSVSETLTSFFKEG 846
L S +N+++ E+ + + FV+ + ++ L +
Sbjct: 2583 LEVLQSSYKNLENELEL--------TKMDKMSFVEKVNKMTAKETEL----------QRE 2624
Query: 847 YVETEQEKMNALEQFS--QNAFQVRQRLLLEAIFQKWDSDGSGFLDLKEVDELL-YTYKE 903
E Q+ E+ S +N +LLLE I D L+ E+ + L +K+
Sbjct: 2625 MHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKD 2684
Query: 904 GMEKESMKK---AKLHIQFPKPHPGHEVRL--SSKQFQNYIELVVSELRGNEDQVLESVV 958
+EKE + A+ ++ + H+ L ++KQ++ I+ +L E+ + +
Sbjct: 2685 QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKL 2744
Query: 959 EFLMNALERSHIESLRNSAR 978
E L +S E L NS +
Sbjct: 2745 EI---DLLKSSKEELNNSLK 2761
>gi|56676335 RAP1 interacting factor 1 [Homo sapiens]
Length = 2472
Score = 49.3 bits (116), Expect = 3e-05
Identities = 65/288 (22%), Positives = 125/288 (43%), Gaps = 33/288 (11%)
Query: 471 LLSANHASKTQSKLLESPDQPKL--NEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQ 528
++SA+ S++ +P+Q L + +R S + E Q + Q +R EE+
Sbjct: 1392 VISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPL 1451
Query: 529 GKKPT--AEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQ 586
K P + L + +I T E+ +E+GS+ T ET + TEQ + K E
Sbjct: 1452 QKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETEQNKKKADPE-- 1509
Query: 587 GPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEE 646
++ +G + + ++ S + + + R++ A QG +S+ E S +E
Sbjct: 1510 -----NIKSEGDGTQDIVDKSSEK-LVRGRTRYQTRRASQG--LLSSIENSESDSSEAKE 1561
Query: 647 PYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQT 706
+ ++ + S E DI Q +++ ++K E I +E + ++ T
Sbjct: 1562 EGSRKKRSGKWKNKSNESVDI----QDQEEKVVKQ----ECIKAE------NQSHDYKAT 1607
Query: 707 YEEEIFLSS---ELQEEVPTLSRKDHFPETTKKEVQKDKP--CEPKSQ 749
EE++ + S E Q+E T+ +D + +V D P CE K++
Sbjct: 1608 SEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNE 1655
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 48.5 bits (114), Expect = 5e-05
Identities = 106/528 (20%), Positives = 216/528 (40%), Gaps = 47/528 (8%)
Query: 255 NRVSKMKENVKQNRKQRESIDKIKVKVANTRKQALQEQFDEWILDPKGMIPKSVIQNVLQ 314
N + ++KE ++ +++++ K + +Q L+E + + K + + +Q LQ
Sbjct: 887 NEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV--KTLTQEKDDLKQ--LQESLQ 942
Query: 315 EFFQNPDFKLGSHCKQLDITDSTEPRLNKMEFTEYISSHIKDLKSEMFEELLKHL----- 369
+ K H D+ E N +E + I LKS++ EE+ ++L
Sbjct: 943 --IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEEN 1000
Query: 370 -CHSADEFRE-VIKADMRRQMFAE--LFLHCDHGKVGFLDRQRTLALLELFYDHSSQMLR 425
+ DEF++ ++ D ++ + A+ L D +++QR + L + QML
Sbjct: 1001 TGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLE 1060
Query: 426 SLLRNPRQWPFIEFEEINLTELWGDMDNQKHIYEGFDKVLLEMNTLL-SANHASKTQSKL 484
S++ Q E I +T ++NQ+ + D++ + + NHA K + +L
Sbjct: 1061 SVIAEKEQLKTDLKENIEMT-----IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGEL 1115
Query: 485 LESPDQPKLNEQRTSTPSPNPPEQQR---GVTAEQGPQRISIEEQQQGKKPTAEQELYIE 541
+ D+ E++ S E+Q+ V E + I E + K +EL +E
Sbjct: 1116 SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE 1175
Query: 542 SV----IEPGTHTESTLEQGSS----RRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSV 593
+ +E E+ S R++L +E + TE+ +G I R +
Sbjct: 1176 HMETERLELAQKLNENYEEVKSITKERKVL--KELQKSFETERDHLRGYI-----REIEA 1228
Query: 594 SEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEE---PYQK 650
+ + E +E D + SV+E+ ++ ++ + + EE +++
Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE 1288
Query: 651 SEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQ----T 706
E P + +SE QE + + S K + I E + + + + S E+ T
Sbjct: 1289 QELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLT 1348
Query: 707 YEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIEGK 754
E + + + EV K+H ET K +Q+ + + +S ++ K
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAK-IQESQSKQEQSLNMKEK 1395
Score = 36.2 bits (82), Expect = 0.25
Identities = 215/1120 (19%), Positives = 428/1120 (38%), Gaps = 184/1120 (16%)
Query: 27 LTEVKELHETLQSV--PDVPVKEDTNSVVEKAMDEIKSQELNLEGQRKISPGSIKDSKTE 84
+ E EL + L+SV +K D +E ++ +EL L G I +
Sbjct: 1049 IQEKNELQQMLESVIAEKEQLKTDLKENIEMTIEN--QEELRLLGDELKKQQEIVAQEK- 1105
Query: 85 ASGNIAIRKSAKVIFALD-----ETELKSKPEHTWKKNL-FERMEARAQAMQQKIIDKEN 138
N AI+K ++ D E +LK K + +K ++ MQ+KI + EN
Sbjct: 1106 ---NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIEN 1162
Query: 139 LKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTAYLLDKLLPTLVPGVENMLTQVEKKKV 198
LK EL+ K L E T+ + +L L E + + +++KV
Sbjct: 1163 LKNELKNK--------ELTLEHMETERL----------ELAQKLNENYEEVKSITKERKV 1204
Query: 199 LTEADTPSKFDPINYLGEYLIRNNPNYIKDPGMSGYQRLMKEVTEDLKIYVPDTICNRVS 258
L E + + + G YI++ +G Q E+LKI
Sbjct: 1205 LKELQKSFETERDHLRG---------YIREIEATGLQ-----TKEELKI--------AHI 1242
Query: 259 KMKENVKQNRKQRESIDKIKVKVANTR-----KQALQEQFDEWILDPKGMIPKSVIQNVL 313
+KE+ + + R S+ + ++ NT+ LQE+ + + + ++P +
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPV-LHEEQELLPNVKEVSET 1301
Query: 314 QEFFQNPDFKLGSHCKQLDITDSTEPRLNKMEFTEYISSHIKDLKS-----EMFEELLKH 368
QE + L D T + ++ E +++KS + + + +
Sbjct: 1302 QETMNELEL-LTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEA 1360
Query: 369 LCHSADEFREVIKADMRR----QMFAELFLHCDHGKVGFLDRQRTLALLELFYDHSSQML 424
L D+ +E I+ + + Q E L+ K + + ++ +E F S +L
Sbjct: 1361 LEVKHDQLKEHIRETLAKIQESQSKQEQSLNM---KEKDNETTKIVSEMEQFKPKDSALL 1417
Query: 425 RSLLRNPRQWPFIEFEEINLTE-LWGDMDNQKHIYEGFDKVLLEMNTLLSANHASKTQ-- 481
R IE E + L++ L D K + + D + L S + K
Sbjct: 1418 R-----------IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK 1466
Query: 482 ---SKLLESPDQPKL-------NEQRTSTPSPNPPEQQRGVTAEQGP------------Q 519
+K LE+ ++ K+ E+ + N E++ ++ Q Q
Sbjct: 1467 EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ 1526
Query: 520 RISIEEQQQGKKPTAEQELYIESVIEPGTH---TESTLEQGSSR------RLLTEQETHR 570
I +E+Q K +E + + + + H +S L+ S+ RL QE +
Sbjct: 1527 EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586
Query: 571 ESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRR 630
E+ + K E R + E +++E VA+ +E E K + + +
Sbjct: 1587 IMIKEKEEMKRVQEALQIERDQLKE--NTKEIVAKMKESQEK--EYQFLKMTAVNETQEK 1642
Query: 631 MSAAEQGSLRESVIEEPYQ----KSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGE 686
M E L+E + ++E +I+ E E++ S ++ R D L+S +
Sbjct: 1643 MCEIEH--LKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD--LRSVEETL 1698
Query: 687 PITSEYIEVPLQEKRSWEQTYEEEI-FLSSELQEEVPTLSRKDHFPETTKKEV---QKDK 742
+ + ++ L+E + + +EE+ + L+E T+ + E+ QKD
Sbjct: 1699 KVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL 1758
Query: 743 PCEPKSQKIEGKSWSGEFFTCNWKMKYVTFEDEEQANLIYG-NSRFTDLHSIIRNIQSCK 801
+ K + E + +K E +E + + G S TD S ++
Sbjct: 1759 EHSNDALKAQDLKIQEELRIAHMHLK----EQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814
Query: 802 EVKGRTAFNGVSFNLLQFVQLLETFVGEDAPLSVSETLTSFFKEGYV---ETEQEKMNAL 858
K + + N Q + L + +S E L K+ + + E E +N
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874
Query: 859 EQFSQNAFQVRQRLLLEAIFQKWDSDGSGFLDLKEVDELLYTYKEGMEKESMKKAK---L 915
++ +N + ++++ ++ D +L+ V+E L ++ + KES+++ K L
Sbjct: 1875 QKLHENLEE------MKSVMKERD-------NLRRVEETLKLERDQL-KESLQETKARDL 1920
Query: 916 HIQ--------FPKPHPGHEVRLSSKQFQNYIEL--VVSELRGNEDQVLESVVEFLMNAL 965
IQ K H +L K + I++ + +L ++D++ + + E L
Sbjct: 1921 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL 1980
Query: 966 ERSHIESLRNSARRK--WLHQIQCAAETSGVSLEPVYSETFKALMQDAEAHGNKKISAHI 1023
+ ++ N + +K + Q++ E +S++ V + F+ KK+ H
Sbjct: 1981 QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQL---------TKKL--HE 2029
Query: 1024 SLLEENLLLPEKGNVLLRNVACTLDDAQFV--LNRVLYRD 1061
SL E ++ E+ + + ++ QF+ L ++ RD
Sbjct: 2030 SLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARD 2069
Score = 34.7 bits (78), Expect = 0.71
Identities = 61/311 (19%), Positives = 120/311 (38%), Gaps = 59/311 (18%)
Query: 7 QEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEIKSQELN 66
+E + KE +E+++ ++ ++ET + + ++ E ++ ++Q+LN
Sbjct: 1610 KENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEI----------EHLKEQFETQKLN 1659
Query: 67 LEG--QRKISPGSIKDSKTEASGNIAIRK----SAKVIFALDETELKSKPEHTWKKNLFE 120
LE I I E ++ + S + ++ +LK T ++L +
Sbjct: 1660 LENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEK 1719
Query: 121 RMEARAQAMQ----QKIIDK------------ENLKKELEKKAEKKLPRDNLAKEWFNTD 164
+ E + M Q+ IDK N++K+LE + +D +E
Sbjct: 1720 QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIA 1779
Query: 165 SMTLNNTAYLLDKLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPN 224
M L +DK L +V + L+ ++K + A K + LI
Sbjct: 1780 HMHLKEQQETIDK-LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI----- 1833
Query: 225 YIKDPGMSGYQRLMKEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKVANT 284
L K+V E K +VS+M++ KQ + Q ++ K++++ N
Sbjct: 1834 -----------TLKKDVNETQK---------KVSEMEQLKKQIKDQSLTLSKLEIENLNL 1873
Query: 285 RKQALQEQFDE 295
Q L E +E
Sbjct: 1874 -AQKLHENLEE 1883
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 48.5 bits (114), Expect = 5e-05
Identities = 56/245 (22%), Positives = 110/245 (44%), Gaps = 32/245 (13%)
Query: 509 QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP----------------GTHTES 552
Q+ + AE+ ++++++Q + T +QE +SV++ ++
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQE---QSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 553 TLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRE- 611
E SRR + E E ++S EQ Q + + + +EQ ++R + AEQ + R+
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 612 --SIAEQDRHKGSVAEQGSRRMSAAEQ--GSLRESVIEEPYQKS-EQGPYGEIISEEQED 666
+ AE ++HK AEQ R+ + EQ +LR + E +QK+ + +E E
Sbjct: 2161 QAADAEMEKHK-KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 667 IGSTSQSRKD------SILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
SQ ++ + + +K I +E + L++K + ++ +EE ++ EE
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 721 VPTLS 725
LS
Sbjct: 2280 AARLS 2284
Score = 43.1 bits (100), Expect = 0.002
Identities = 60/294 (20%), Positives = 116/294 (39%), Gaps = 53/294 (18%)
Query: 469 NTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPE--QQRGVTAEQGPQRISIEEQ 526
N L TQ L E ++ K + + S E + R + E Q+ ++ E+
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310
Query: 527 QQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQ-HKGSIEG 585
+K A QE + L Q +RRL ++E + E+ Q + ++E
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 586 QGPRRVSVSEQGSSRESVAEQGSRRESIAEQDR--------------HKGSVAEQGS--- 628
+ R++ +S + + + SR ++ AE+D H+ +A Q
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 629 -------RRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQ--------- 672
R+ S + LRE++ E +K + +++ + E++ + Q
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 673 ------SRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
S KDS+L+ ++ E QEK EQ +++E+ + +L+EE
Sbjct: 2491 LQQSFLSEKDSLLQRERFIE-----------QEKAKLEQLFQDEVAKAQQLREE 2533
Score = 39.7 bits (91), Expect = 0.022
Identities = 56/273 (20%), Positives = 108/273 (39%), Gaps = 49/273 (17%)
Query: 472 LSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKK 531
L AN A + + + E Q L + E+Q+ + +R EEQ ++
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEA--------EKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 532 PTAEQELYIESVIEPGT------------HTESTLEQGSSRRLLTEQETHR--ESTTEQG 577
AEQEL + + GT + EQG +R L E+E R
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 578 QHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKG------SVAEQGSRRM 631
Q + +E + + + E + ++ AE+ SR S + R + +AE+ +R
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 632 SAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSE 691
+ AE+ + + EE + ++ +++E+ IG ++ + ++
Sbjct: 1808 ALAEEAKRQRQLAEEDAAR-QRAEAERVLAEKLAAIGEATRLKTEA-------------- 1852
Query: 692 YIEVPLQEKRSWEQTY----EEEIFLSSELQEE 720
E+ L+EK + + E+E F L+E+
Sbjct: 1853 --EIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1883
Score = 33.5 bits (75), Expect = 1.6
Identities = 52/296 (17%), Positives = 130/296 (43%), Gaps = 20/296 (6%)
Query: 462 DKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRI 521
++VL E + KT++++ + + + +R + + Q+R + + +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 522 SIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQH-K 580
IEE+ + ++ EL + + E TL Q RR + E+ +++ E+ K
Sbjct: 1890 DIEERLAQLRKASDSELERQKGL-----VEDTLRQ---RRQVEEEILALKASFEKAAAGK 1941
Query: 581 GSIEGQ-GPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSL 639
+E + G R + + S+E + +R+ +A ++ + AE+ ++ AAE+ +
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 640 RE--SVIEEPYQ-KSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVP 696
R+ + +EE + K++ + +++ Q +++ K + E + ++
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ-- 2059
Query: 697 LQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIE 752
Q+++ +QT ++E + +L+ E R E + VQ ++ +++E
Sbjct: 2060 -QKEQELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE 2112
Score = 32.7 bits (73), Expect = 2.7
Identities = 41/191 (21%), Positives = 85/191 (44%), Gaps = 14/191 (7%)
Query: 508 QQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLE--QGSSRRLLTE 565
QQ AE+ + I+ E+++ K + L ++S E L+ Q + L+E
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Query: 566 QETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHK-GSVA 624
+++ + Q K +E V+ ++Q + E+ R++ EQ+R + +
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ------LREEQQRQQQQMEQERQRLVASM 2552
Query: 625 EQGSRRMSAAEQGSLRESVIEEPYQKSEQ--GPYGEIISEEQEDIGSTSQSRKDSILKST 682
E+ RR AE+G R+ +E Q+ EQ E+++EE + + Q ++ +
Sbjct: 2553 EEARRRQHEAEEGVRRK---QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 683 KYGEPITSEYI 693
+ E +T+ +
Sbjct: 2610 AHSEEVTASQV 2620
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 48.5 bits (114), Expect = 5e-05
Identities = 56/245 (22%), Positives = 110/245 (44%), Gaps = 32/245 (13%)
Query: 509 QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP----------------GTHTES 552
Q+ + AE+ ++++++Q + T +QE +SV++ ++
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQE---QSVLDQLRGEAEAARRAAEEAEEARVQA 2104
Query: 553 TLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRE- 611
E SRR + E E ++S EQ Q + + + +EQ ++R + AEQ + R+
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2164
Query: 612 --SIAEQDRHKGSVAEQGSRRMSAAEQ--GSLRESVIEEPYQKS-EQGPYGEIISEEQED 666
+ AE ++HK AEQ R+ + EQ +LR + E +QK+ + +E E
Sbjct: 2165 QAADAEMEKHK-KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2223
Query: 667 IGSTSQSRKD------SILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
SQ ++ + + +K I +E + L++K + ++ +EE ++ EE
Sbjct: 2224 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283
Query: 721 VPTLS 725
LS
Sbjct: 2284 AARLS 2288
Score = 43.1 bits (100), Expect = 0.002
Identities = 60/294 (20%), Positives = 116/294 (39%), Gaps = 53/294 (18%)
Query: 469 NTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPE--QQRGVTAEQGPQRISIEEQ 526
N L TQ L E ++ K + + S E + R + E Q+ ++ E+
Sbjct: 2255 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2314
Query: 527 QQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQ-HKGSIEG 585
+K A QE + L Q +RRL ++E + E+ Q + ++E
Sbjct: 2315 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374
Query: 586 QGPRRVSVSEQGSSRESVAEQGSRRESIAEQDR--------------HKGSVAEQGS--- 628
+ R++ +S + + + SR ++ AE+D H+ +A Q
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2434
Query: 629 -------RRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQ--------- 672
R+ S + LRE++ E +K + +++ + E++ + Q
Sbjct: 2435 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494
Query: 673 ------SRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
S KDS+L+ ++ E QEK EQ +++E+ + +L+EE
Sbjct: 2495 LQQSFLSEKDSLLQRERFIE-----------QEKAKLEQLFQDEVAKAQQLREE 2537
Score = 39.7 bits (91), Expect = 0.022
Identities = 56/273 (20%), Positives = 108/273 (39%), Gaps = 49/273 (17%)
Query: 472 LSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKK 531
L AN A + + + E Q L + E+Q+ + +R EEQ ++
Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQAEA--------EKQKEEAEREARRRGKAEEQAVRQR 1691
Query: 532 PTAEQELYIESVIEPGT------------HTESTLEQGSSRRLLTEQETHR--ESTTEQG 577
AEQEL + + GT + EQG +R L E+E R
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1751
Query: 578 QHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKG------SVAEQGSRRM 631
Q + +E + + + E + ++ AE+ SR S + R + +AE+ +R
Sbjct: 1752 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1811
Query: 632 SAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSE 691
+ AE+ + + EE + ++ +++E+ IG ++ + ++
Sbjct: 1812 ALAEEAKRQRQLAEEDAAR-QRAEAERVLAEKLAAIGEATRLKTEA-------------- 1856
Query: 692 YIEVPLQEKRSWEQTY----EEEIFLSSELQEE 720
E+ L+EK + + E+E F L+E+
Sbjct: 1857 --EIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1887
Score = 33.5 bits (75), Expect = 1.6
Identities = 52/296 (17%), Positives = 130/296 (43%), Gaps = 20/296 (6%)
Query: 462 DKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRI 521
++VL E + KT++++ + + + +R + + Q+R + + +
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1893
Query: 522 SIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQH-K 580
IEE+ + ++ EL + + E TL Q RR + E+ +++ E+ K
Sbjct: 1894 DIEERLAQLRKASDSELERQKGL-----VEDTLRQ---RRQVEEEILALKASFEKAAAGK 1945
Query: 581 GSIEGQ-GPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSL 639
+E + G R + + S+E + +R+ +A ++ + AE+ ++ AAE+ +
Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2005
Query: 640 RE--SVIEEPYQ-KSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVP 696
R+ + +EE + K++ + +++ Q +++ K + E + ++
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ-- 2063
Query: 697 LQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIE 752
Q+++ +QT ++E + +L+ E R E + VQ ++ +++E
Sbjct: 2064 -QKEQELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE 2116
Score = 32.7 bits (73), Expect = 2.7
Identities = 41/191 (21%), Positives = 85/191 (44%), Gaps = 14/191 (7%)
Query: 508 QQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLE--QGSSRRLLTE 565
QQ AE+ + I+ E+++ K + L ++S E L+ Q + L+E
Sbjct: 2443 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2502
Query: 566 QETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHK-GSVA 624
+++ + Q K +E V+ ++Q + E+ R++ EQ+R + +
Sbjct: 2503 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ------LREEQQRQQQQMEQERQRLVASM 2556
Query: 625 EQGSRRMSAAEQGSLRESVIEEPYQKSEQ--GPYGEIISEEQEDIGSTSQSRKDSILKST 682
E+ RR AE+G R+ +E Q+ EQ E+++EE + + Q ++ +
Sbjct: 2557 EEARRRQHEAEEGVRRK---QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2613
Query: 683 KYGEPITSEYI 693
+ E +T+ +
Sbjct: 2614 AHSEEVTASQV 2624
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 48.5 bits (114), Expect = 5e-05
Identities = 56/245 (22%), Positives = 110/245 (44%), Gaps = 32/245 (13%)
Query: 509 QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP----------------GTHTES 552
Q+ + AE+ ++++++Q + T +QE +SV++ ++
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQE---QSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 553 TLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRE- 611
E SRR + E E ++S EQ Q + + + +EQ ++R + AEQ + R+
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 612 --SIAEQDRHKGSVAEQGSRRMSAAEQ--GSLRESVIEEPYQKS-EQGPYGEIISEEQED 666
+ AE ++HK AEQ R+ + EQ +LR + E +QK+ + +E E
Sbjct: 2161 QAADAEMEKHK-KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 667 IGSTSQSRKD------SILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
SQ ++ + + +K I +E + L++K + ++ +EE ++ EE
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 721 VPTLS 725
LS
Sbjct: 2280 AARLS 2284
Score = 43.1 bits (100), Expect = 0.002
Identities = 60/294 (20%), Positives = 116/294 (39%), Gaps = 53/294 (18%)
Query: 469 NTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPE--QQRGVTAEQGPQRISIEEQ 526
N L TQ L E ++ K + + S E + R + E Q+ ++ E+
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310
Query: 527 QQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQ-HKGSIEG 585
+K A QE + L Q +RRL ++E + E+ Q + ++E
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 586 QGPRRVSVSEQGSSRESVAEQGSRRESIAEQDR--------------HKGSVAEQGS--- 628
+ R++ +S + + + SR ++ AE+D H+ +A Q
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 629 -------RRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQ--------- 672
R+ S + LRE++ E +K + +++ + E++ + Q
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 673 ------SRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
S KDS+L+ ++ E QEK EQ +++E+ + +L+EE
Sbjct: 2491 LQQSFLSEKDSLLQRERFIE-----------QEKAKLEQLFQDEVAKAQQLREE 2533
Score = 39.7 bits (91), Expect = 0.022
Identities = 56/273 (20%), Positives = 108/273 (39%), Gaps = 49/273 (17%)
Query: 472 LSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKK 531
L AN A + + + E Q L + E+Q+ + +R EEQ ++
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEA--------EKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 532 PTAEQELYIESVIEPGT------------HTESTLEQGSSRRLLTEQETHR--ESTTEQG 577
AEQEL + + GT + EQG +R L E+E R
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 578 QHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKG------SVAEQGSRRM 631
Q + +E + + + E + ++ AE+ SR S + R + +AE+ +R
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 632 SAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSE 691
+ AE+ + + EE + ++ +++E+ IG ++ + ++
Sbjct: 1808 ALAEEAKRQRQLAEEDAAR-QRAEAERVLAEKLAAIGEATRLKTEA-------------- 1852
Query: 692 YIEVPLQEKRSWEQTY----EEEIFLSSELQEE 720
E+ L+EK + + E+E F L+E+
Sbjct: 1853 --EIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1883
Score = 33.5 bits (75), Expect = 1.6
Identities = 52/296 (17%), Positives = 130/296 (43%), Gaps = 20/296 (6%)
Query: 462 DKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRI 521
++VL E + KT++++ + + + +R + + Q+R + + +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 522 SIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQH-K 580
IEE+ + ++ EL + + E TL Q RR + E+ +++ E+ K
Sbjct: 1890 DIEERLAQLRKASDSELERQKGL-----VEDTLRQ---RRQVEEEILALKASFEKAAAGK 1941
Query: 581 GSIEGQ-GPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSL 639
+E + G R + + S+E + +R+ +A ++ + AE+ ++ AAE+ +
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 640 RE--SVIEEPYQ-KSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVP 696
R+ + +EE + K++ + +++ Q +++ K + E + ++
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ-- 2059
Query: 697 LQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIE 752
Q+++ +QT ++E + +L+ E R E + VQ ++ +++E
Sbjct: 2060 -QKEQELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE 2112
Score = 32.7 bits (73), Expect = 2.7
Identities = 41/191 (21%), Positives = 85/191 (44%), Gaps = 14/191 (7%)
Query: 508 QQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLE--QGSSRRLLTE 565
QQ AE+ + I+ E+++ K + L ++S E L+ Q + L+E
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Query: 566 QETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHK-GSVA 624
+++ + Q K +E V+ ++Q + E+ R++ EQ+R + +
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ------LREEQQRQQQQMEQERQRLVASM 2552
Query: 625 EQGSRRMSAAEQGSLRESVIEEPYQKSEQ--GPYGEIISEEQEDIGSTSQSRKDSILKST 682
E+ RR AE+G R+ +E Q+ EQ E+++EE + + Q ++ +
Sbjct: 2553 EEARRRQHEAEEGVRRK---QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 683 KYGEPITSEYI 693
+ E +T+ +
Sbjct: 2610 AHSEEVTASQV 2620
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 48.5 bits (114), Expect = 5e-05
Identities = 56/245 (22%), Positives = 110/245 (44%), Gaps = 32/245 (13%)
Query: 509 QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP----------------GTHTES 552
Q+ + AE+ ++++++Q + T +QE +SV++ ++
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQE---QSVLDQLRGEAEAARRAAEEAEEARVQA 2068
Query: 553 TLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRE- 611
E SRR + E E ++S EQ Q + + + +EQ ++R + AEQ + R+
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2128
Query: 612 --SIAEQDRHKGSVAEQGSRRMSAAEQ--GSLRESVIEEPYQKS-EQGPYGEIISEEQED 666
+ AE ++HK AEQ R+ + EQ +LR + E +QK+ + +E E
Sbjct: 2129 QAADAEMEKHK-KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2187
Query: 667 IGSTSQSRKD------SILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
SQ ++ + + +K I +E + L++K + ++ +EE ++ EE
Sbjct: 2188 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247
Query: 721 VPTLS 725
LS
Sbjct: 2248 AARLS 2252
Score = 43.1 bits (100), Expect = 0.002
Identities = 60/294 (20%), Positives = 116/294 (39%), Gaps = 53/294 (18%)
Query: 469 NTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPE--QQRGVTAEQGPQRISIEEQ 526
N L TQ L E ++ K + + S E + R + E Q+ ++ E+
Sbjct: 2219 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2278
Query: 527 QQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQ-HKGSIEG 585
+K A QE + L Q +RRL ++E + E+ Q + ++E
Sbjct: 2279 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338
Query: 586 QGPRRVSVSEQGSSRESVAEQGSRRESIAEQDR--------------HKGSVAEQGS--- 628
+ R++ +S + + + SR ++ AE+D H+ +A Q
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2398
Query: 629 -------RRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQ--------- 672
R+ S + LRE++ E +K + +++ + E++ + Q
Sbjct: 2399 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458
Query: 673 ------SRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
S KDS+L+ ++ E QEK EQ +++E+ + +L+EE
Sbjct: 2459 LQQSFLSEKDSLLQRERFIE-----------QEKAKLEQLFQDEVAKAQQLREE 2501
Score = 39.7 bits (91), Expect = 0.022
Identities = 56/273 (20%), Positives = 108/273 (39%), Gaps = 49/273 (17%)
Query: 472 LSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKK 531
L AN A + + + E Q L + E+Q+ + +R EEQ ++
Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQAEA--------EKQKEEAEREARRRGKAEEQAVRQR 1655
Query: 532 PTAEQELYIESVIEPGT------------HTESTLEQGSSRRLLTEQETHR--ESTTEQG 577
AEQEL + + GT + EQG +R L E+E R
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1715
Query: 578 QHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKG------SVAEQGSRRM 631
Q + +E + + + E + ++ AE+ SR S + R + +AE+ +R
Sbjct: 1716 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1775
Query: 632 SAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSE 691
+ AE+ + + EE + ++ +++E+ IG ++ + ++
Sbjct: 1776 ALAEEAKRQRQLAEEDAAR-QRAEAERVLAEKLAAIGEATRLKTEA-------------- 1820
Query: 692 YIEVPLQEKRSWEQTY----EEEIFLSSELQEE 720
E+ L+EK + + E+E F L+E+
Sbjct: 1821 --EIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1851
Score = 33.5 bits (75), Expect = 1.6
Identities = 52/296 (17%), Positives = 130/296 (43%), Gaps = 20/296 (6%)
Query: 462 DKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRI 521
++VL E + KT++++ + + + +R + + Q+R + + +
Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1857
Query: 522 SIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQH-K 580
IEE+ + ++ EL + + E TL Q RR + E+ +++ E+ K
Sbjct: 1858 DIEERLAQLRKASDSELERQKGL-----VEDTLRQ---RRQVEEEILALKASFEKAAAGK 1909
Query: 581 GSIEGQ-GPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSL 639
+E + G R + + S+E + +R+ +A ++ + AE+ ++ AAE+ +
Sbjct: 1910 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1969
Query: 640 RE--SVIEEPYQ-KSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVP 696
R+ + +EE + K++ + +++ Q +++ K + E + ++
Sbjct: 1970 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ-- 2027
Query: 697 LQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIE 752
Q+++ +QT ++E + +L+ E R E + VQ ++ +++E
Sbjct: 2028 -QKEQELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE 2080
Score = 32.7 bits (73), Expect = 2.7
Identities = 41/191 (21%), Positives = 85/191 (44%), Gaps = 14/191 (7%)
Query: 508 QQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLE--QGSSRRLLTE 565
QQ AE+ + I+ E+++ K + L ++S E L+ Q + L+E
Sbjct: 2407 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2466
Query: 566 QETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHK-GSVA 624
+++ + Q K +E V+ ++Q + E+ R++ EQ+R + +
Sbjct: 2467 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ------LREEQQRQQQQMEQERQRLVASM 2520
Query: 625 EQGSRRMSAAEQGSLRESVIEEPYQKSEQ--GPYGEIISEEQEDIGSTSQSRKDSILKST 682
E+ RR AE+G R+ +E Q+ EQ E+++EE + + Q ++ +
Sbjct: 2521 EEARRRQHEAEEGVRRK---QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2577
Query: 683 KYGEPITSEYI 693
+ E +T+ +
Sbjct: 2578 AHSEEVTASQV 2588
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 48.5 bits (114), Expect = 5e-05
Identities = 56/245 (22%), Positives = 110/245 (44%), Gaps = 32/245 (13%)
Query: 509 QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP----------------GTHTES 552
Q+ + AE+ ++++++Q + T +QE +SV++ ++
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQE---QSVLDQLRGEAEAARRAAEEAEEARVQA 2237
Query: 553 TLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRE- 611
E SRR + E E ++S EQ Q + + + +EQ ++R + AEQ + R+
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297
Query: 612 --SIAEQDRHKGSVAEQGSRRMSAAEQ--GSLRESVIEEPYQKS-EQGPYGEIISEEQED 666
+ AE ++HK AEQ R+ + EQ +LR + E +QK+ + +E E
Sbjct: 2298 QAADAEMEKHK-KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2356
Query: 667 IGSTSQSRKD------SILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
SQ ++ + + +K I +E + L++K + ++ +EE ++ EE
Sbjct: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416
Query: 721 VPTLS 725
LS
Sbjct: 2417 AARLS 2421
Score = 43.1 bits (100), Expect = 0.002
Identities = 60/294 (20%), Positives = 116/294 (39%), Gaps = 53/294 (18%)
Query: 469 NTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPE--QQRGVTAEQGPQRISIEEQ 526
N L TQ L E ++ K + + S E + R + E Q+ ++ E+
Sbjct: 2388 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2447
Query: 527 QQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQ-HKGSIEG 585
+K A QE + L Q +RRL ++E + E+ Q + ++E
Sbjct: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507
Query: 586 QGPRRVSVSEQGSSRESVAEQGSRRESIAEQDR--------------HKGSVAEQGS--- 628
+ R++ +S + + + SR ++ AE+D H+ +A Q
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2567
Query: 629 -------RRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQ--------- 672
R+ S + LRE++ E +K + +++ + E++ + Q
Sbjct: 2568 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627
Query: 673 ------SRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
S KDS+L+ ++ E QEK EQ +++E+ + +L+EE
Sbjct: 2628 LQQSFLSEKDSLLQRERFIE-----------QEKAKLEQLFQDEVAKAQQLREE 2670
Score = 39.7 bits (91), Expect = 0.022
Identities = 56/273 (20%), Positives = 108/273 (39%), Gaps = 49/273 (17%)
Query: 472 LSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKK 531
L AN A + + + E Q L + E+Q+ + +R EEQ ++
Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQAEA--------EKQKEEAEREARRRGKAEEQAVRQR 1824
Query: 532 PTAEQELYIESVIEPGT------------HTESTLEQGSSRRLLTEQETHR--ESTTEQG 577
AEQEL + + GT + EQG +R L E+E R
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1884
Query: 578 QHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKG------SVAEQGSRRM 631
Q + +E + + + E + ++ AE+ SR S + R + +AE+ +R
Sbjct: 1885 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1944
Query: 632 SAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSE 691
+ AE+ + + EE + ++ +++E+ IG ++ + ++
Sbjct: 1945 ALAEEAKRQRQLAEEDAAR-QRAEAERVLAEKLAAIGEATRLKTEA-------------- 1989
Query: 692 YIEVPLQEKRSWEQTY----EEEIFLSSELQEE 720
E+ L+EK + + E+E F L+E+
Sbjct: 1990 --EIALKEKEAENERLRRLAEDEAFQRRRLEEQ 2020
Score = 33.5 bits (75), Expect = 1.6
Identities = 52/296 (17%), Positives = 130/296 (43%), Gaps = 20/296 (6%)
Query: 462 DKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRI 521
++VL E + KT++++ + + + +R + + Q+R + + +
Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026
Query: 522 SIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQH-K 580
IEE+ + ++ EL + + E TL Q RR + E+ +++ E+ K
Sbjct: 2027 DIEERLAQLRKASDSELERQKGL-----VEDTLRQ---RRQVEEEILALKASFEKAAAGK 2078
Query: 581 GSIEGQ-GPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSL 639
+E + G R + + S+E + +R+ +A ++ + AE+ ++ AAE+ +
Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2138
Query: 640 RE--SVIEEPYQ-KSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVP 696
R+ + +EE + K++ + +++ Q +++ K + E + ++
Sbjct: 2139 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ-- 2196
Query: 697 LQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIE 752
Q+++ +QT ++E + +L+ E R E + VQ ++ +++E
Sbjct: 2197 -QKEQELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE 2249
Score = 32.7 bits (73), Expect = 2.7
Identities = 41/191 (21%), Positives = 85/191 (44%), Gaps = 14/191 (7%)
Query: 508 QQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLE--QGSSRRLLTE 565
QQ AE+ + I+ E+++ K + L ++S E L+ Q + L+E
Sbjct: 2576 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2635
Query: 566 QETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHK-GSVA 624
+++ + Q K +E V+ ++Q + E+ R++ EQ+R + +
Sbjct: 2636 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ------LREEQQRQQQQMEQERQRLVASM 2689
Query: 625 EQGSRRMSAAEQGSLRESVIEEPYQKSEQ--GPYGEIISEEQEDIGSTSQSRKDSILKST 682
E+ RR AE+G R+ +E Q+ EQ E+++EE + + Q ++ +
Sbjct: 2690 EEARRRQHEAEEGVRRK---QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2746
Query: 683 KYGEPITSEYI 693
+ E +T+ +
Sbjct: 2747 AHSEEVTASQV 2757
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 48.5 bits (114), Expect = 5e-05
Identities = 56/245 (22%), Positives = 110/245 (44%), Gaps = 32/245 (13%)
Query: 509 QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP----------------GTHTES 552
Q+ + AE+ ++++++Q + T +QE +SV++ ++
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQE---QSVLDQLRGEAEAARRAAEEAEEARVQA 2078
Query: 553 TLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRE- 611
E SRR + E E ++S EQ Q + + + +EQ ++R + AEQ + R+
Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2138
Query: 612 --SIAEQDRHKGSVAEQGSRRMSAAEQ--GSLRESVIEEPYQKS-EQGPYGEIISEEQED 666
+ AE ++HK AEQ R+ + EQ +LR + E +QK+ + +E E
Sbjct: 2139 QAADAEMEKHK-KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2197
Query: 667 IGSTSQSRKD------SILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
SQ ++ + + +K I +E + L++K + ++ +EE ++ EE
Sbjct: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257
Query: 721 VPTLS 725
LS
Sbjct: 2258 AARLS 2262
Score = 43.1 bits (100), Expect = 0.002
Identities = 60/294 (20%), Positives = 116/294 (39%), Gaps = 53/294 (18%)
Query: 469 NTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPE--QQRGVTAEQGPQRISIEEQ 526
N L TQ L E ++ K + + S E + R + E Q+ ++ E+
Sbjct: 2229 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2288
Query: 527 QQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQ-HKGSIEG 585
+K A QE + L Q +RRL ++E + E+ Q + ++E
Sbjct: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
Query: 586 QGPRRVSVSEQGSSRESVAEQGSRRESIAEQDR--------------HKGSVAEQGS--- 628
+ R++ +S + + + SR ++ AE+D H+ +A Q
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2408
Query: 629 -------RRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQ--------- 672
R+ S + LRE++ E +K + +++ + E++ + Q
Sbjct: 2409 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468
Query: 673 ------SRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
S KDS+L+ ++ E QEK EQ +++E+ + +L+EE
Sbjct: 2469 LQQSFLSEKDSLLQRERFIE-----------QEKAKLEQLFQDEVAKAQQLREE 2511
Score = 39.7 bits (91), Expect = 0.022
Identities = 56/273 (20%), Positives = 108/273 (39%), Gaps = 49/273 (17%)
Query: 472 LSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKK 531
L AN A + + + E Q L + E+Q+ + +R EEQ ++
Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQAEA--------EKQKEEAEREARRRGKAEEQAVRQR 1665
Query: 532 PTAEQELYIESVIEPGT------------HTESTLEQGSSRRLLTEQETHR--ESTTEQG 577
AEQEL + + GT + EQG +R L E+E R
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1725
Query: 578 QHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKG------SVAEQGSRRM 631
Q + +E + + + E + ++ AE+ SR S + R + +AE+ +R
Sbjct: 1726 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1785
Query: 632 SAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSE 691
+ AE+ + + EE + ++ +++E+ IG ++ + ++
Sbjct: 1786 ALAEEAKRQRQLAEEDAAR-QRAEAERVLAEKLAAIGEATRLKTEA-------------- 1830
Query: 692 YIEVPLQEKRSWEQTY----EEEIFLSSELQEE 720
E+ L+EK + + E+E F L+E+
Sbjct: 1831 --EIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1861
Score = 33.5 bits (75), Expect = 1.6
Identities = 52/296 (17%), Positives = 130/296 (43%), Gaps = 20/296 (6%)
Query: 462 DKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRI 521
++VL E + KT++++ + + + +R + + Q+R + + +
Sbjct: 1810 ERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867
Query: 522 SIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQH-K 580
IEE+ + ++ EL + + E TL Q RR + E+ +++ E+ K
Sbjct: 1868 DIEERLAQLRKASDSELERQKGL-----VEDTLRQ---RRQVEEEILALKASFEKAAAGK 1919
Query: 581 GSIEGQ-GPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSL 639
+E + G R + + S+E + +R+ +A ++ + AE+ ++ AAE+ +
Sbjct: 1920 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1979
Query: 640 RE--SVIEEPYQ-KSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVP 696
R+ + +EE + K++ + +++ Q +++ K + E + ++
Sbjct: 1980 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ-- 2037
Query: 697 LQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIE 752
Q+++ +QT ++E + +L+ E R E + VQ ++ +++E
Sbjct: 2038 -QKEQELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE 2090
Score = 32.7 bits (73), Expect = 2.7
Identities = 41/191 (21%), Positives = 85/191 (44%), Gaps = 14/191 (7%)
Query: 508 QQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLE--QGSSRRLLTE 565
QQ AE+ + I+ E+++ K + L ++S E L+ Q + L+E
Sbjct: 2417 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2476
Query: 566 QETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHK-GSVA 624
+++ + Q K +E V+ ++Q + E+ R++ EQ+R + +
Sbjct: 2477 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ------LREEQQRQQQQMEQERQRLVASM 2530
Query: 625 EQGSRRMSAAEQGSLRESVIEEPYQKSEQ--GPYGEIISEEQEDIGSTSQSRKDSILKST 682
E+ RR AE+G R+ +E Q+ EQ E+++EE + + Q ++ +
Sbjct: 2531 EEARRRQHEAEEGVRRK---QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2587
Query: 683 KYGEPITSEYI 693
+ E +T+ +
Sbjct: 2588 AHSEEVTASQV 2598
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 48.5 bits (114), Expect = 5e-05
Identities = 56/245 (22%), Positives = 110/245 (44%), Gaps = 32/245 (13%)
Query: 509 QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP----------------GTHTES 552
Q+ + AE+ ++++++Q + T +QE +SV++ ++
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQTLQQE---QSVLDQLRGEAEAARRAAEEAEEARVQA 2086
Query: 553 TLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRE- 611
E SRR + E E ++S EQ Q + + + +EQ ++R + AEQ + R+
Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2146
Query: 612 --SIAEQDRHKGSVAEQGSRRMSAAEQ--GSLRESVIEEPYQKS-EQGPYGEIISEEQED 666
+ AE ++HK AEQ R+ + EQ +LR + E +QK+ + +E E
Sbjct: 2147 QAADAEMEKHK-KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2205
Query: 667 IGSTSQSRKD------SILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
SQ ++ + + +K I +E + L++K + ++ +EE ++ EE
Sbjct: 2206 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265
Query: 721 VPTLS 725
LS
Sbjct: 2266 AARLS 2270
Score = 43.1 bits (100), Expect = 0.002
Identities = 60/294 (20%), Positives = 116/294 (39%), Gaps = 53/294 (18%)
Query: 469 NTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPE--QQRGVTAEQGPQRISIEEQ 526
N L TQ L E ++ K + + S E + R + E Q+ ++ E+
Sbjct: 2237 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2296
Query: 527 QQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQ-HKGSIEG 585
+K A QE + L Q +RRL ++E + E+ Q + ++E
Sbjct: 2297 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356
Query: 586 QGPRRVSVSEQGSSRESVAEQGSRRESIAEQDR--------------HKGSVAEQGS--- 628
+ R++ +S + + + SR ++ AE+D H+ +A Q
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2416
Query: 629 -------RRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQ--------- 672
R+ S + LRE++ E +K + +++ + E++ + Q
Sbjct: 2417 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476
Query: 673 ------SRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
S KDS+L+ ++ E QEK EQ +++E+ + +L+EE
Sbjct: 2477 LQQSFLSEKDSLLQRERFIE-----------QEKAKLEQLFQDEVAKAQQLREE 2519
Score = 39.7 bits (91), Expect = 0.022
Identities = 56/273 (20%), Positives = 108/273 (39%), Gaps = 49/273 (17%)
Query: 472 LSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKK 531
L AN A + + + E Q L + E+Q+ + +R EEQ ++
Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQAEA--------EKQKEEAEREARRRGKAEEQAVRQR 1673
Query: 532 PTAEQELYIESVIEPGT------------HTESTLEQGSSRRLLTEQETHR--ESTTEQG 577
AEQEL + + GT + EQG +R L E+E R
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1733
Query: 578 QHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKG------SVAEQGSRRM 631
Q + +E + + + E + ++ AE+ SR S + R + +AE+ +R
Sbjct: 1734 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1793
Query: 632 SAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSE 691
+ AE+ + + EE + ++ +++E+ IG ++ + ++
Sbjct: 1794 ALAEEAKRQRQLAEEDAAR-QRAEAERVLAEKLAAIGEATRLKTEA-------------- 1838
Query: 692 YIEVPLQEKRSWEQTY----EEEIFLSSELQEE 720
E+ L+EK + + E+E F L+E+
Sbjct: 1839 --EIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1869
Score = 33.5 bits (75), Expect = 1.6
Identities = 52/296 (17%), Positives = 130/296 (43%), Gaps = 20/296 (6%)
Query: 462 DKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRI 521
++VL E + KT++++ + + + +R + + Q+R + + +
Sbjct: 1818 ERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1875
Query: 522 SIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQH-K 580
IEE+ + ++ EL + + E TL Q RR + E+ +++ E+ K
Sbjct: 1876 DIEERLAQLRKASDSELERQKGL-----VEDTLRQ---RRQVEEEILALKASFEKAAAGK 1927
Query: 581 GSIEGQ-GPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSL 639
+E + G R + + S+E + +R+ +A ++ + AE+ ++ AAE+ +
Sbjct: 1928 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1987
Query: 640 RE--SVIEEPYQ-KSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVP 696
R+ + +EE + K++ + +++ Q +++ K + E + ++
Sbjct: 1988 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ-- 2045
Query: 697 LQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIE 752
Q+++ +QT ++E + +L+ E R E + VQ ++ +++E
Sbjct: 2046 -QKEQELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE 2098
Score = 32.7 bits (73), Expect = 2.7
Identities = 41/191 (21%), Positives = 85/191 (44%), Gaps = 14/191 (7%)
Query: 508 QQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLE--QGSSRRLLTE 565
QQ AE+ + I+ E+++ K + L ++S E L+ Q + L+E
Sbjct: 2425 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2484
Query: 566 QETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHK-GSVA 624
+++ + Q K +E V+ ++Q + E+ R++ EQ+R + +
Sbjct: 2485 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ------LREEQQRQQQQMEQERQRLVASM 2538
Query: 625 EQGSRRMSAAEQGSLRESVIEEPYQKSEQ--GPYGEIISEEQEDIGSTSQSRKDSILKST 682
E+ RR AE+G R+ +E Q+ EQ E+++EE + + Q ++ +
Sbjct: 2539 EEARRRQHEAEEGVRRK---QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2595
Query: 683 KYGEPITSEYI 693
+ E +T+ +
Sbjct: 2596 AHSEEVTASQV 2606
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 48.5 bits (114), Expect = 5e-05
Identities = 56/245 (22%), Positives = 110/245 (44%), Gaps = 32/245 (13%)
Query: 509 QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP----------------GTHTES 552
Q+ + AE+ ++++++Q + T +QE +SV++ ++
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQE---QSVLDQLRGEAEAARRAAEEAEEARVQA 2127
Query: 553 TLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRE- 611
E SRR + E E ++S EQ Q + + + +EQ ++R + AEQ + R+
Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2187
Query: 612 --SIAEQDRHKGSVAEQGSRRMSAAEQ--GSLRESVIEEPYQKS-EQGPYGEIISEEQED 666
+ AE ++HK AEQ R+ + EQ +LR + E +QK+ + +E E
Sbjct: 2188 QAADAEMEKHK-KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2246
Query: 667 IGSTSQSRKD------SILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
SQ ++ + + +K I +E + L++K + ++ +EE ++ EE
Sbjct: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306
Query: 721 VPTLS 725
LS
Sbjct: 2307 AARLS 2311
Score = 43.1 bits (100), Expect = 0.002
Identities = 60/294 (20%), Positives = 116/294 (39%), Gaps = 53/294 (18%)
Query: 469 NTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPE--QQRGVTAEQGPQRISIEEQ 526
N L TQ L E ++ K + + S E + R + E Q+ ++ E+
Sbjct: 2278 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2337
Query: 527 QQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQ-HKGSIEG 585
+K A QE + L Q +RRL ++E + E+ Q + ++E
Sbjct: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
Query: 586 QGPRRVSVSEQGSSRESVAEQGSRRESIAEQDR--------------HKGSVAEQGS--- 628
+ R++ +S + + + SR ++ AE+D H+ +A Q
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2457
Query: 629 -------RRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQ--------- 672
R+ S + LRE++ E +K + +++ + E++ + Q
Sbjct: 2458 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
Query: 673 ------SRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
S KDS+L+ ++ E QEK EQ +++E+ + +L+EE
Sbjct: 2518 LQQSFLSEKDSLLQRERFIE-----------QEKAKLEQLFQDEVAKAQQLREE 2560
Score = 39.7 bits (91), Expect = 0.022
Identities = 56/273 (20%), Positives = 108/273 (39%), Gaps = 49/273 (17%)
Query: 472 LSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKK 531
L AN A + + + E Q L + E+Q+ + +R EEQ ++
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEA--------EKQKEEAEREARRRGKAEEQAVRQR 1714
Query: 532 PTAEQELYIESVIEPGT------------HTESTLEQGSSRRLLTEQETHR--ESTTEQG 577
AEQEL + + GT + EQG +R L E+E R
Sbjct: 1715 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1774
Query: 578 QHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKG------SVAEQGSRRM 631
Q + +E + + + E + ++ AE+ SR S + R + +AE+ +R
Sbjct: 1775 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1834
Query: 632 SAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSE 691
+ AE+ + + EE + ++ +++E+ IG ++ + ++
Sbjct: 1835 ALAEEAKRQRQLAEEDAAR-QRAEAERVLAEKLAAIGEATRLKTEA-------------- 1879
Query: 692 YIEVPLQEKRSWEQTY----EEEIFLSSELQEE 720
E+ L+EK + + E+E F L+E+
Sbjct: 1880 --EIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1910
Score = 33.5 bits (75), Expect = 1.6
Identities = 52/296 (17%), Positives = 130/296 (43%), Gaps = 20/296 (6%)
Query: 462 DKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRI 521
++VL E + KT++++ + + + +R + + Q+R + + +
Sbjct: 1859 ERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916
Query: 522 SIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQH-K 580
IEE+ + ++ EL + + E TL Q RR + E+ +++ E+ K
Sbjct: 1917 DIEERLAQLRKASDSELERQKGL-----VEDTLRQ---RRQVEEEILALKASFEKAAAGK 1968
Query: 581 GSIEGQ-GPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSL 639
+E + G R + + S+E + +R+ +A ++ + AE+ ++ AAE+ +
Sbjct: 1969 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2028
Query: 640 RE--SVIEEPYQ-KSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVP 696
R+ + +EE + K++ + +++ Q +++ K + E + ++
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ-- 2086
Query: 697 LQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIE 752
Q+++ +QT ++E + +L+ E R E + VQ ++ +++E
Sbjct: 2087 -QKEQELQQTLQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE 2139
Score = 32.7 bits (73), Expect = 2.7
Identities = 41/191 (21%), Positives = 85/191 (44%), Gaps = 14/191 (7%)
Query: 508 QQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLE--QGSSRRLLTE 565
QQ AE+ + I+ E+++ K + L ++S E L+ Q + L+E
Sbjct: 2466 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2525
Query: 566 QETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHK-GSVA 624
+++ + Q K +E V+ ++Q + E+ R++ EQ+R + +
Sbjct: 2526 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ------LREEQQRQQQQMEQERQRLVASM 2579
Query: 625 EQGSRRMSAAEQGSLRESVIEEPYQKSEQ--GPYGEIISEEQEDIGSTSQSRKDSILKST 682
E+ RR AE+G R+ +E Q+ EQ E+++EE + + Q ++ +
Sbjct: 2580 EEARRRQHEAEEGVRRK---QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2636
Query: 683 KYGEPITSEYI 693
+ E +T+ +
Sbjct: 2637 AHSEEVTASQV 2647
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 47.8 bits (112), Expect = 8e-05
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 24/325 (7%)
Query: 441 EINLTELWGDMDNQKHIYEGFDKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTST 500
++ ELW ++ Q+ E + + K+ E ++ + E++
Sbjct: 284 QVEENELWNRLNQQQ-----------EEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIRE 332
Query: 501 PSPNPPEQQRGVTAEQGPQRISIEEQ-QQGKKPTAEQELYIESVIEPGTHTESTLEQGSS 559
Q+ + ++ R E ++ +K ++E+ E + E E+
Sbjct: 333 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 392
Query: 560 RRLLTEQETHRESTTEQG---QHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQ 616
R L E+ +E EQ Q + I Q R+ ++ E + EQ E I EQ
Sbjct: 393 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ---EEKIREQ 449
Query: 617 DRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKD 676
++ E+ + E+ +E EE +++ E+ E I ++E + + +
Sbjct: 450 EKKMWRQEEKIHEQEKIREEEKRQEQ--EEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRK 507
Query: 677 SILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKK 736
K + E I + ++ QE++ W Q EE+I E+ E + ++ E K+
Sbjct: 508 QEEKVWRQEEKIREQEEKIREQEEKMWRQ--EEKIREQEEMWREEEKMHEQEKIWEEEKR 565
Query: 737 EVQKDKPC--EPKSQKIEGKSWSGE 759
+ Q+DK E K ++ E K W E
Sbjct: 566 QEQEDKMWRQEEKIREQEEKVWRQE 590
Score = 34.3 bits (77), Expect = 0.93
Identities = 47/285 (16%), Positives = 114/285 (40%), Gaps = 42/285 (14%)
Query: 18 KEDKERKWNLTE-VKELHETLQSVPDVPVKEDTNSVVEKAMDEIKSQELNLEGQRKISPG 76
++ +E+ W E ++E E +Q + ++E + E+ + +E+ E + K+
Sbjct: 296 QQQEEKMWRQEEKIQEWEEKIQEQEE-KIREQEEKIREQEEKMRRQEEMMWEKEEKMR-- 352
Query: 77 SIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLFERMEARAQAMQQKIIDK 136
+ + +R+ ++++ +E +++ + E W+K R Q+KI ++
Sbjct: 353 --RQEEMMWEKEEKMRRQEEMMWEKEE-KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 409
Query: 137 ENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTAYLLDKLLPTLVPGVENMLTQVEKK 196
E ++E EK E++ ++ AK W + + E + + EKK
Sbjct: 410 EEKRQEEEKIREQEKRQEQEAKMWRQEEK-----------------IREQEEKIREQEKK 452
Query: 197 KVLTEADTPSKFDPINYLGEYLIRNNPNYIKDPGMSGYQRLMKEVTEDLKIYVPDTICNR 256
+ E I ++ + + + ++ KI+ + I +
Sbjct: 453 M---------------WRQEEKIHEQEKIREEEKRQEQEEMWR---QEEKIHEQEEIWRQ 494
Query: 257 VSKMKENVKQNRKQRESIDKIKVKVANTRKQALQEQFDEWILDPK 301
KM E ++ RKQ E + + + K+ ++ +++ W + K
Sbjct: 495 KEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEK 539
Score = 34.3 bits (77), Expect = 0.93
Identities = 27/146 (18%), Positives = 69/146 (47%), Gaps = 8/146 (5%)
Query: 7 QEELRPAQENRKEDKERKWNLTE-VKELHETLQSVPDVPVKEDTNSVVEKAMDEIKSQEL 65
+E++R +E R+E +E+ W E ++E E +Q + ++E + E+ + +E
Sbjct: 590 EEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQE-QEEKIREQEEKIREQEEMTQEQEEK 648
Query: 66 NLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEH-TWKKNLFERMEA 124
E + K+ ++ K + R+ K+ E +++ + E ++ + + E
Sbjct: 649 MGEQEEKMCE---QEEKMQEQEETMWRQEEKI--REQEKKIREQEEKIREQEEMMQEQEE 703
Query: 125 RAQAMQQKIIDKENLKKELEKKAEKK 150
+ ++K+ ++E +E E+K ++
Sbjct: 704 KMWEQEEKMCEQEEKMQEQEEKMRRQ 729
Score = 33.9 bits (76), Expect = 1.2
Identities = 51/252 (20%), Positives = 104/252 (41%), Gaps = 16/252 (6%)
Query: 479 KTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQEL 538
+ + K+ E ++ + E++ EQ+ + EQ + EE+ + ++ +E
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIR-EQEEKMWRQEEKIREQEEMWREE- 550
Query: 539 YIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQ-G 597
E + E E Q ++ ++E RE + + + I Q +R E+
Sbjct: 551 --EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMW 608
Query: 598 SSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYG 657
E + EQ E I EQ+ + EQ + E +E + E Q+ +
Sbjct: 609 KQEEKIREQ---EEKIQEQEE---KIREQEEKIREQEEMTQEQEEKMGE--QEEKMCEQE 660
Query: 658 EIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSE- 716
E + E++E + + ++ K + E I + + QE++ WEQ EE++ E
Sbjct: 661 EKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ--EEKMCEQEEK 718
Query: 717 LQEEVPTLSRKD 728
+QE+ + R++
Sbjct: 719 MQEQEEKMRRQE 730
Score = 31.2 bits (69), Expect = 7.9
Identities = 28/140 (20%), Positives = 57/140 (40%), Gaps = 14/140 (10%)
Query: 7 QEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEIKSQELN 66
+E++R +E + +E W E E + + ++ + EK + +E+
Sbjct: 327 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 386
Query: 67 LEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLFERMEARA 126
E + KI K + E IR ++ E + + E ++ + EA+
Sbjct: 387 WEKEEKIRELEEKMHEQEK-----IR---------EQEEKRQEEEKIREQEKRQEQEAKM 432
Query: 127 QAMQQKIIDKENLKKELEKK 146
++KI ++E +E EKK
Sbjct: 433 WRQEEKIREQEEKIREQEKK 452
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 47.4 bits (111), Expect = 1e-04
Identities = 154/767 (20%), Positives = 315/767 (41%), Gaps = 112/767 (14%)
Query: 7 QEELRPAQENRKEDKERKWNLTE-VKELHETLQSVP---DVPVKEDTNSVVEKAMDEIKS 62
Q+ ++ Q + E ++ L + +K++++ L S D+ +E VEK +
Sbjct: 291 QKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEEC 350
Query: 63 QELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKV--IFALDETELKSKPEHTWKKNLFE 120
+ L LE K+ P ++K S T + +SA V +F L + ++ E +L
Sbjct: 351 ENLKLECS-KLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSL-- 407
Query: 121 RMEARAQAMQQKIIDKENLKKELEKKA-EKKLPRDNLAKEWFNTDSMTLNNTAYLLDKLL 179
Q + ++NLK ++ + EK+ + KE + LNN ++
Sbjct: 408 --------NQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTA 459
Query: 180 P---TLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNYIKDPGMSGYQR 236
+L + ++ +E K+ K I + E L R N K + Q
Sbjct: 460 TRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE-LDRQNQEATKHMILIKDQ- 517
Query: 237 LMKEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKVANTRKQALQEQFDEW 296
L K+ E I +SK+K+++ +K+ ++ K+ + T++ +Q++
Sbjct: 518 LSKQQNEGDSI---------ISKLKQDLNDEKKRVHQLEDDKMDI--TKELDVQKE---- 562
Query: 297 ILDPKGMIPKSVIQNVLQEFFQNPDFKLGSHCKQLDITDSTEPRLNK--MEFTEYISSHI 354
+I V N L Q + K+ + QL+ + + + K +E E+I +
Sbjct: 563 -----KLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNE 617
Query: 355 KDLKSEMFEELLKHLCHSADE-FREVI----KADMR--RQMFAELF-LHCDHGKVGFLDR 406
++L S + EL++ L ++ F++ + +A++R +Q +EL L+ + KV F +
Sbjct: 618 EEL-SRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVK 676
Query: 407 QRTLALLELFYDHSSQMLRSLLRNPR---------QWPFIEFEEINLTELWGDMDNQKHI 457
L+ D Q+ L N + + +E EI W +K +
Sbjct: 677 MENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWA----KKRL 732
Query: 458 YEGFDKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQG 517
E +K + L +A + + T + LE KLN+++ + ++ T +
Sbjct: 733 LEEANKYEKTIEELSNARNLN-TSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKE 791
Query: 518 PQRI---SIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTT 574
+ + S+EEQ+Q + ++E++IE + E + + L++ S + L + E R++
Sbjct: 792 TKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYS--QALRKNEILRQTIE 849
Query: 575 EQGQHKGSIEGQG-------------PRRVSVSEQGSSRESVAEQGSR-------RESIA 614
E+ + GS++ + R + + +SV E S +E +
Sbjct: 850 EKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLE 909
Query: 615 EQDRHKGSVAE-QGSRRMSAAEQGSLRESVIEEPYQKSEQ--GPYGEIISEEQEDIGSTS 671
E+ +H + E Q +M + ++ ++E + EQ + ++ E+ E+I S
Sbjct: 910 EEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQ 969
Query: 672 QSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQ 718
+ T E I+ L E+R QT +IF +++Q
Sbjct: 970 K----------------TIEQIKTQLHEERQDIQTDNSDIFQETKVQ 1000
>gi|222537747 hypothetical protein LOC342979 [Homo sapiens]
Length = 673
Score = 46.2 bits (108), Expect = 2e-04
Identities = 39/139 (28%), Positives = 70/139 (50%), Gaps = 8/139 (5%)
Query: 507 EQQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTE- 565
E++RG E+ + + +E++ ++P A +E +E+ + G T ++G L TE
Sbjct: 472 EEKRGAEEEEVEEPLGVEKKGGEEEPEATKEP-LEAERKGGEETLEAEKRGGEESLETEK 530
Query: 566 -QETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVA 624
Q T + EQG +GS E Q ++E G E+ E +E Q++ G++
Sbjct: 531 TQGTEGDLNLEQGSREGS-ESQAEE---MNEAGPPLEANTETRPEKEGPQPQEKPVGALE 586
Query: 625 EQGSRRMSAAE-QGSLRES 642
E+G + +AAE QG L ++
Sbjct: 587 EEGVKPQTAAEGQGPLGDA 605
Score = 33.5 bits (75), Expect = 1.6
Identities = 43/173 (24%), Positives = 68/173 (39%), Gaps = 27/173 (15%)
Query: 524 EEQQQGKKPTAEQELYIESVIEPGTHT--------------ESTLE---QGSSRRLLTEQ 566
EE + +K AE+ + I S +PGT E LE +GS+ +L TE+
Sbjct: 388 EETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTER 447
Query: 567 ETHRE----STTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGS 622
E E +G + EG +R + E+ V ++G E E +
Sbjct: 448 EGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEE--PEATKEPLE 505
Query: 623 VAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRK 675
+G AE+ ES+ E QG G++ E+ GS SQ+ +
Sbjct: 506 AERKGGEETLEAEKRGGEESLETE----KTQGTEGDLNLEQGSREGSESQAEE 554
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 46.2 bits (108), Expect = 2e-04
Identities = 70/292 (23%), Positives = 119/292 (40%), Gaps = 34/292 (11%)
Query: 463 KVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRIS 522
K+LLE + AN +S + P++ K + + +P E + V +E S
Sbjct: 1236 KMLLEE---IKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSE------S 1286
Query: 523 IEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGS 582
+ ++ KKP L + T S E G ++ T+ + H+E + S
Sbjct: 1287 DSDSEESKKPRYRHRLLRHKL------TVSDGESGEEKK--TKPKEHKEVKGRNRRKVSS 1338
Query: 583 IEGQGP--RRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLR 640
+ + + VSE+ S E +R AE + ++ S ++ RR ++ S
Sbjct: 1339 EDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSS 1398
Query: 641 ESVI---EEPYQKSEQGPYGEIISEEQEDIGSTSQS----RKD--SILKSTKYGEPITSE 691
E+ EE +K E+ E EE+ED S+S RK ILK K +
Sbjct: 1399 ENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNA 1458
Query: 692 YIEVPLQEKRSWEQTYE-EEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDK 742
E + KR E+ E E++ E+++ PT P TTK + +D+
Sbjct: 1459 LKEEEERRKRIAEREREREKLREVIEIEDASPT-----KCPITTKLVLDEDE 1505
Score = 39.7 bits (91), Expect = 0.022
Identities = 65/309 (21%), Positives = 123/309 (39%), Gaps = 37/309 (11%)
Query: 472 LSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKK 531
+ NH + K D K +R S+ S + + ++G +A+ SI ++ K+
Sbjct: 719 IHTNHKTLYDLKTQAGKDD-KGKRKRKSSTSGSDFDTKKGKSAKS-----SIISKK--KR 770
Query: 532 PTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRV 591
T + +S +E + S + + + +S+ ++ K ++ QG + +
Sbjct: 771 QTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNL 830
Query: 592 SVSEQGSS----RESVAEQGSRRESIAEQD------------RHKGSVAEQGSRRMSAAE 635
S++GSS R+ E S E ++D + + S + G ++S E
Sbjct: 831 KTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKE 890
Query: 636 QG--SLRESVIEEPYQKSE--QGPYGEIISEEQEDIGS--TSQSRKDSILKSTKYGEPIT 689
Q SL + E +KS+ + + + + DI + + D + K
Sbjct: 891 QSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKG 950
Query: 690 SEYIEVPLQEKR---SWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEP 746
+E + P K+ EQ YE SS+ E++P HFP+ K+ E
Sbjct: 951 TEEKKKPSDFKKKVIKMEQQYES----SSDGTEKLPEREEICHFPKGIKQIKNGTTDGEK 1006
Query: 747 KSQKIEGKS 755
KS+KI K+
Sbjct: 1007 KSKKIRDKT 1015
Score = 33.1 bits (74), Expect = 2.1
Identities = 33/126 (26%), Positives = 54/126 (42%), Gaps = 9/126 (7%)
Query: 4 SASQEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSV----VEKAMDE 59
S S++E RP + K K L E + ++ + + V+ED++S E+ +E
Sbjct: 1356 SESEDEQRPRTRSAK-----KAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEE 1410
Query: 60 IKSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLF 119
+ +E E + + DSK+ G IRK K ET+ K E +K +
Sbjct: 1411 KEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIA 1470
Query: 120 ERMEAR 125
ER R
Sbjct: 1471 ERERER 1476
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 46.2 bits (108), Expect = 2e-04
Identities = 70/292 (23%), Positives = 119/292 (40%), Gaps = 34/292 (11%)
Query: 463 KVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRIS 522
K+LLE + AN +S + P++ K + + +P E + V +E S
Sbjct: 1274 KMLLEE---IKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSE------S 1324
Query: 523 IEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGS 582
+ ++ KKP L + T S E G ++ T+ + H+E + S
Sbjct: 1325 DSDSEESKKPRYRHRLLRHKL------TVSDGESGEEKK--TKPKEHKEVKGRNRRKVSS 1376
Query: 583 IEGQGP--RRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLR 640
+ + + VSE+ S E +R AE + ++ S ++ RR ++ S
Sbjct: 1377 EDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSS 1436
Query: 641 ESVI---EEPYQKSEQGPYGEIISEEQEDIGSTSQS----RKD--SILKSTKYGEPITSE 691
E+ EE +K E+ E EE+ED S+S RK ILK K +
Sbjct: 1437 ENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNA 1496
Query: 692 YIEVPLQEKRSWEQTYE-EEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDK 742
E + KR E+ E E++ E+++ PT P TTK + +D+
Sbjct: 1497 LKEEEERRKRIAEREREREKLREVIEIEDASPT-----KCPITTKLVLDEDE 1543
Score = 39.7 bits (91), Expect = 0.022
Identities = 65/309 (21%), Positives = 123/309 (39%), Gaps = 37/309 (11%)
Query: 472 LSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKK 531
+ NH + K D K +R S+ S + + ++G +A+ SI ++ K+
Sbjct: 757 IHTNHKTLYDLKTQAGKDD-KGKRKRKSSTSGSDFDTKKGKSAKS-----SIISKK--KR 808
Query: 532 PTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRV 591
T + +S +E + S + + + +S+ ++ K ++ QG + +
Sbjct: 809 QTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNL 868
Query: 592 SVSEQGSS----RESVAEQGSRRESIAEQD------------RHKGSVAEQGSRRMSAAE 635
S++GSS R+ E S E ++D + + S + G ++S E
Sbjct: 869 KTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKE 928
Query: 636 QG--SLRESVIEEPYQKSE--QGPYGEIISEEQEDIGS--TSQSRKDSILKSTKYGEPIT 689
Q SL + E +KS+ + + + + DI + + D + K
Sbjct: 929 QSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKG 988
Query: 690 SEYIEVPLQEKR---SWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEP 746
+E + P K+ EQ YE SS+ E++P HFP+ K+ E
Sbjct: 989 TEEKKKPSDFKKKVIKMEQQYES----SSDGTEKLPEREEICHFPKGIKQIKNGTTDGEK 1044
Query: 747 KSQKIEGKS 755
KS+KI K+
Sbjct: 1045 KSKKIRDKT 1053
Score = 33.1 bits (74), Expect = 2.1
Identities = 33/126 (26%), Positives = 54/126 (42%), Gaps = 9/126 (7%)
Query: 4 SASQEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSV----VEKAMDE 59
S S++E RP + K K L E + ++ + + V+ED++S E+ +E
Sbjct: 1394 SESEDEQRPRTRSAK-----KAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEE 1448
Query: 60 IKSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLF 119
+ +E E + + DSK+ G IRK K ET+ K E +K +
Sbjct: 1449 KEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIA 1508
Query: 120 ERMEAR 125
ER R
Sbjct: 1509 ERERER 1514
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 45.4 bits (106), Expect = 4e-04
Identities = 138/767 (17%), Positives = 295/767 (38%), Gaps = 76/767 (9%)
Query: 7 QEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEIKSQELN 66
+E + N E++E+ NLT++K HE++ S +V +K++ EK+ E++ +
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-----EKSRQELEKLKRK 1059
Query: 67 LEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKS-----KPEHTWKKNLFER 121
LEG I D + + + K+ A E EL++ E K N ++
Sbjct: 1060 LEGDASDFHEQIADLQAQIA-------ELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 122 ---MEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTA------ 172
+E +Q+ +D E + +K ++ L + A + D TL++TA
Sbjct: 1113 IRELEGHISDLQED-LDSERAARNKAEKQKRDLGEELEALKTELED--TLDSTATQQELR 1169
Query: 173 -------YLLDKLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNY 225
+L K L E + ++ +K + + + L +N
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 226 IKD-PGMSGYQRLM---KEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKV 281
K+ ++G R++ K+ E K + + SK + + + + + K++ +V
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 282 ANTRKQALQEQFDEWILDPKGMIPKSVIQNVLQEFFQ---NPDFKLGSHCKQL-DITDST 337
+ L E + I K + S QE Q + + +QL + +S
Sbjct: 1290 ESVTGM-LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1348
Query: 338 EPRLN-KMEFTEYISSHIKDLKSEMFEELLKHLCHSADEFREVIKADMRRQMFAELFLHC 396
+ +L+ +ME + + HI L ++ + K L A + + R Q E
Sbjct: 1349 QDQLDEEMEAKQNLERHISTLNIQL-SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407
Query: 397 DHGKVGFLDR--------QRTLALLELFYDHSSQMLRSLLRNPRQWPFIEFEEINLTELW 448
K D+ Q+ L L + D+ Q++ +L + R++ + EE N++ +
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 449 GDMDNQKHIYEGFDK------VLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPS 502
D + + E +K + + L A + +K+L++ + ++ + +
Sbjct: 1468 AD-ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 503 PNPPEQ-QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP-----GTHTESTLEQ 556
+ E+ +R + + + +EE + + T + +L +E ++ ++ EQ
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 557 GSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQ 616
+R +++ H T + + K ++ + RE +Q
Sbjct: 1587 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1646
Query: 617 DRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEI-ISEEQEDIGSTSQSRK 675
R + + R + A + R+ + + ++ E + + QED+ + ++RK
Sbjct: 1647 LRKLQAQMKDFQRELEDAR--ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 676 DSILKSTKYGEPITSEYI--EVPLQEKRSWEQTYEEEIFLSSELQEE 720
+ L+ + E + S EKR E + L EL+EE
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ---LEEELEEE 1748
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 45.4 bits (106), Expect = 4e-04
Identities = 138/767 (17%), Positives = 295/767 (38%), Gaps = 76/767 (9%)
Query: 7 QEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEIKSQELN 66
+E + N E++E+ NLT++K HE++ S +V +K++ EK+ E++ +
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-----EKSRQELEKLKRK 1066
Query: 67 LEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKS-----KPEHTWKKNLFER 121
LEG I D + + + K+ A E EL++ E K N ++
Sbjct: 1067 LEGDASDFHEQIADLQAQIA-------ELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 122 ---MEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTA------ 172
+E +Q+ +D E + +K ++ L + A + D TL++TA
Sbjct: 1120 IRELEGHISDLQED-LDSERAARNKAEKQKRDLGEELEALKTELED--TLDSTATQQELR 1176
Query: 173 -------YLLDKLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNY 225
+L K L E + ++ +K + + + L +N
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 226 IKD-PGMSGYQRLM---KEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKV 281
K+ ++G R++ K+ E K + + SK + + + + + K++ +V
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 282 ANTRKQALQEQFDEWILDPKGMIPKSVIQNVLQEFFQ---NPDFKLGSHCKQL-DITDST 337
+ L E + I K + S QE Q + + +QL + +S
Sbjct: 1297 ESVTGM-LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355
Query: 338 EPRLN-KMEFTEYISSHIKDLKSEMFEELLKHLCHSADEFREVIKADMRRQMFAELFLHC 396
+ +L+ +ME + + HI L ++ + K L A + + R Q E
Sbjct: 1356 QDQLDEEMEAKQNLERHISTLNIQL-SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1414
Query: 397 DHGKVGFLDR--------QRTLALLELFYDHSSQMLRSLLRNPRQWPFIEFEEINLTELW 448
K D+ Q+ L L + D+ Q++ +L + R++ + EE N++ +
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 449 GDMDNQKHIYEGFDK------VLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPS 502
D + + E +K + + L A + +K+L++ + ++ + +
Sbjct: 1475 AD-ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 503 PNPPEQ-QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP-----GTHTESTLEQ 556
+ E+ +R + + + +EE + + T + +L +E ++ ++ EQ
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 557 GSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQ 616
+R +++ H T + + K ++ + RE +Q
Sbjct: 1594 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1653
Query: 617 DRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEI-ISEEQEDIGSTSQSRK 675
R + + R + A + R+ + + ++ E + + QED+ + ++RK
Sbjct: 1654 LRKLQAQMKDFQRELEDAR--ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 676 DSILKSTKYGEPITSEYI--EVPLQEKRSWEQTYEEEIFLSSELQEE 720
+ L+ + E + S EKR E + L EL+EE
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ---LEEELEEE 1755
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 45.4 bits (106), Expect = 4e-04
Identities = 138/767 (17%), Positives = 295/767 (38%), Gaps = 76/767 (9%)
Query: 7 QEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEIKSQELN 66
+E + N E++E+ NLT++K HE++ S +V +K++ EK+ E++ +
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-----EKSRQELEKLKRK 1066
Query: 67 LEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKS-----KPEHTWKKNLFER 121
LEG I D + + + K+ A E EL++ E K N ++
Sbjct: 1067 LEGDASDFHEQIADLQAQIA-------ELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 122 ---MEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTA------ 172
+E +Q+ +D E + +K ++ L + A + D TL++TA
Sbjct: 1120 IRELEGHISDLQED-LDSERAARNKAEKQKRDLGEELEALKTELED--TLDSTATQQELR 1176
Query: 173 -------YLLDKLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNY 225
+L K L E + ++ +K + + + L +N
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 226 IKD-PGMSGYQRLM---KEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKV 281
K+ ++G R++ K+ E K + + SK + + + + + K++ +V
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 282 ANTRKQALQEQFDEWILDPKGMIPKSVIQNVLQEFFQ---NPDFKLGSHCKQL-DITDST 337
+ L E + I K + S QE Q + + +QL + +S
Sbjct: 1297 ESVTGM-LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355
Query: 338 EPRLN-KMEFTEYISSHIKDLKSEMFEELLKHLCHSADEFREVIKADMRRQMFAELFLHC 396
+ +L+ +ME + + HI L ++ + K L A + + R Q E
Sbjct: 1356 QDQLDEEMEAKQNLERHISTLNIQL-SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1414
Query: 397 DHGKVGFLDR--------QRTLALLELFYDHSSQMLRSLLRNPRQWPFIEFEEINLTELW 448
K D+ Q+ L L + D+ Q++ +L + R++ + EE N++ +
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 449 GDMDNQKHIYEGFDK------VLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPS 502
D + + E +K + + L A + +K+L++ + ++ + +
Sbjct: 1475 AD-ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 503 PNPPEQ-QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP-----GTHTESTLEQ 556
+ E+ +R + + + +EE + + T + +L +E ++ ++ EQ
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 557 GSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQ 616
+R +++ H T + + K ++ + RE +Q
Sbjct: 1594 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1653
Query: 617 DRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEI-ISEEQEDIGSTSQSRK 675
R + + R + A + R+ + + ++ E + + QED+ + ++RK
Sbjct: 1654 LRKLQAQMKDFQRELEDAR--ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 676 DSILKSTKYGEPITSEYI--EVPLQEKRSWEQTYEEEIFLSSELQEE 720
+ L+ + E + S EKR E + L EL+EE
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ---LEEELEEE 1755
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 45.4 bits (106), Expect = 4e-04
Identities = 138/767 (17%), Positives = 295/767 (38%), Gaps = 76/767 (9%)
Query: 7 QEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEIKSQELN 66
+E + N E++E+ NLT++K HE++ S +V +K++ EK+ E++ +
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-----EKSRQELEKLKRK 1059
Query: 67 LEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKS-----KPEHTWKKNLFER 121
LEG I D + + + K+ A E EL++ E K N ++
Sbjct: 1060 LEGDASDFHEQIADLQAQIA-------ELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 122 ---MEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTA------ 172
+E +Q+ +D E + +K ++ L + A + D TL++TA
Sbjct: 1113 IRELEGHISDLQED-LDSERAARNKAEKQKRDLGEELEALKTELED--TLDSTATQQELR 1169
Query: 173 -------YLLDKLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNY 225
+L K L E + ++ +K + + + L +N
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 226 IKD-PGMSGYQRLM---KEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIKVKV 281
K+ ++G R++ K+ E K + + SK + + + + + K++ +V
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 282 ANTRKQALQEQFDEWILDPKGMIPKSVIQNVLQEFFQ---NPDFKLGSHCKQL-DITDST 337
+ L E + I K + S QE Q + + +QL + +S
Sbjct: 1290 ESVTGM-LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1348
Query: 338 EPRLN-KMEFTEYISSHIKDLKSEMFEELLKHLCHSADEFREVIKADMRRQMFAELFLHC 396
+ +L+ +ME + + HI L ++ + K L A + + R Q E
Sbjct: 1349 QDQLDEEMEAKQNLERHISTLNIQL-SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407
Query: 397 DHGKVGFLDR--------QRTLALLELFYDHSSQMLRSLLRNPRQWPFIEFEEINLTELW 448
K D+ Q+ L L + D+ Q++ +L + R++ + EE N++ +
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 449 GDMDNQKHIYEGFDK------VLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPS 502
D + + E +K + + L A + +K+L++ + ++ + +
Sbjct: 1468 AD-ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 503 PNPPEQ-QRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP-----GTHTESTLEQ 556
+ E+ +R + + + +EE + + T + +L +E ++ ++ EQ
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 557 GSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQ 616
+R +++ H T + + K ++ + RE +Q
Sbjct: 1587 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1646
Query: 617 DRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEI-ISEEQEDIGSTSQSRK 675
R + + R + A + R+ + + ++ E + + QED+ + ++RK
Sbjct: 1647 LRKLQAQMKDFQRELEDAR--ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 676 DSILKSTKYGEPITSEYI--EVPLQEKRSWEQTYEEEIFLSSELQEE 720
+ L+ + E + S EKR E + L EL+EE
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ---LEEELEEE 1748
>gi|7706635 cornulin [Homo sapiens]
Length = 495
Score = 45.1 bits (105), Expect = 5e-04
Identities = 50/184 (27%), Positives = 89/184 (48%), Gaps = 19/184 (10%)
Query: 495 EQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTES-- 552
EQ +S + +Q + T +Q E QG+ T++ + I+ GTHT++
Sbjct: 243 EQDSSHQTGRTSKQTQEATNDQNR---GTETHGQGRSQTSQAVTGGHAQIQAGTHTQTPT 299
Query: 553 -TLEQGSSRRLLTEQETHRESTTEQGQHKGS-IEGQGPRRVSVSEQGSSRESVAEQGSRR 610
T+EQ SS + + +EST GQ++G+ I GQG + S + G + + GS
Sbjct: 300 QTVEQDSSHQTGSTSTQTQEST--NGQNRGTEIHGQGRSQTSQAVTGGHTQ--IQAGSHT 355
Query: 611 ESIAEQDRHKGSVAEQGSRRMSAAEQGSLR-ESVIEEPYQKSEQGPYGEIISEEQEDIGS 669
E++ EQDR + +V+ G+R EQG + + + + + GE + Q G+
Sbjct: 356 ETV-EQDRSQ-TVSHGGAR-----EQGQTQTQPGSGQRWMQVSNPEAGETVPGGQAQTGA 408
Query: 670 TSQS 673
+++S
Sbjct: 409 STES 412
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 44.7 bits (104), Expect = 7e-04
Identities = 61/315 (19%), Positives = 116/315 (36%), Gaps = 40/315 (12%)
Query: 481 QSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQELYI 540
+ K ES ++ + + S P+Q+ EE++QG + E
Sbjct: 213 EEKTTESQEETVVMSLKNGQISSEEPKQE--------------EEREQGSDEISHHEKME 258
Query: 541 ESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSR 600
E E + LE R+ EQ+ + + + Q R E+ R
Sbjct: 259 EEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMR 318
Query: 601 ESVAEQGSRRESIAEQDRHKGSVAEQ-GSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEI 659
E R+ I E+++ ++ AAE+ R+ + EE + +E+
Sbjct: 319 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE---RQRIKEEEKRAAEERQRARA 375
Query: 660 ISEEQEDIGSTSQSR----KDSILKSTKY-GEPITSEYIEVPLQEKRSWEQTYEEEIFLS 714
EE+ + +++ K ++ TK GE + + + EK++ E + +
Sbjct: 376 EEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKK 435
Query: 715 -------------SELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIEG----KSWS 757
+LQE+ PT +++ E KK+ + + + + +G KS +
Sbjct: 436 QGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 495
Query: 758 GEFFTCNWKMKYVTF 772
GEF T K TF
Sbjct: 496 GEFMTHKLKHTENTF 510
Score = 34.7 bits (78), Expect = 0.71
Identities = 37/148 (25%), Positives = 69/148 (46%), Gaps = 15/148 (10%)
Query: 1 MNESASQEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKE-DTNSVVEKAMDE 59
+ +S + + R A+EN+KEDKE++ E + ++ +V V+E T S E +
Sbjct: 168 VTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMS 227
Query: 60 IKSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLF 119
+K+ +++ E ++ ++ + + S I+ + E E K + E +
Sbjct: 228 LKNGQISSEEPKQ------EEEREQGSDEISHHEKM-------EEEDKERAEAERARLEA 274
Query: 120 ERMEARAQAMQQKIIDKENLKKELEKKA 147
E E R +A Q K I E + E E+KA
Sbjct: 275 EERE-RIKAEQDKKIADERARIEAEEKA 301
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 44.3 bits (103), Expect = 0.001
Identities = 106/512 (20%), Positives = 191/512 (37%), Gaps = 83/512 (16%)
Query: 284 TRKQALQEQFDEWILDPKGMIPKSVIQNV------LQEFFQNP--DFKLGSHCKQLDITD 335
+R + EQ DE + + +S Q + ++ F++P + S K+ +
Sbjct: 37 SRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRT 96
Query: 336 STEPRLNKMEFTEYISSHIKDLKSEMFEELLKHLCHSADEFREVIKADMRRQMFAELFLH 395
S+ LN+++ +S D S+M E + +S +E + +RR E L
Sbjct: 97 SSRESLNRLDLDSSTASF--DPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRM---ERSLS 151
Query: 396 CDHGKVGFLDRQRTLALLELFYDHSSQMLRSLLRNPRQWPFIEFEEINLTELWGDMDNQK 455
GK L + L+ +L + E+ EL D +K
Sbjct: 152 SYRGKYS------ELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELR-EELQMDQQAKK 204
Query: 456 HIYEGFDKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAE 515
H+ E FD L E + +S +TQ LL+ + P P Q T E
Sbjct: 205 HLQEEFDASLEEKDQYIS---VLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKE 261
Query: 516 QGPQRISIEEQQQGKKPTAEQELYIESVIEPGT--HTESTLEQGSSR------RLLTEQE 567
+ P+ E V+E GT T TL+Q R R +
Sbjct: 262 ENPESDG------------------EPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ 303
Query: 568 THRESTTEQGQHKGSIEGQGPRRVSVSEQ------GSSRESVAEQGSRRESIAEQDRHKG 621
+H+E T K +++ Q R+ E+ + + + + I + ++ KG
Sbjct: 304 SHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKG 363
Query: 622 SVAEQGSRRM---------------SAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQED 666
V + R+M S +Q + + + E +KSE+ + EE E
Sbjct: 364 MVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAF-----EELEK 418
Query: 667 IGSTSQSRKDSILK-STKYGEPI-----TSEYIEVPLQEKRSWEQTYEEEIFLSSELQEE 720
ST+Q +++ K + E I TSE + LQ++ S + +E + + + EE
Sbjct: 419 ALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELS--RVKQEVVDVMKKSSEE 476
Query: 721 VPTLSRKDHFPETTKKEVQKDKPCEPKSQKIE 752
+K H E +KE + K + + ++ +
Sbjct: 477 QIAKLQKLHEKELARKEQELTKKLQTREREFQ 508
Score = 40.4 bits (93), Expect = 0.013
Identities = 122/654 (18%), Positives = 252/654 (38%), Gaps = 120/654 (18%)
Query: 462 DKVLLEMNTLLSANHASKTQS---KLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGP 518
+K+ +++N L N + Q K+L D+ K++E + + + E+ + + +
Sbjct: 1137 EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTD--EEFQSLKSSHEK 1194
Query: 519 QRISIEEQQQGKKPTAEQ---ELYI-----ESVIEPGTHTESTLEQGSSRRLLTEQETHR 570
S+E++ K +E+ +L I E+++E T+ + + +L+ +
Sbjct: 1195 SNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQ 1254
Query: 571 ESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRR 630
TT+ E + +VSE + + E+ + +Q H+ E +
Sbjct: 1255 HRTTKVK------EALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKS 1308
Query: 631 MSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITS 690
M A + V E+ + E G + SE++ I + ++I T E +
Sbjct: 1309 MKA----DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364
Query: 691 EYIEVPLQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQ- 749
+ +E+ K+ + L+ +LQ + +LS K+ + +K+ ++K CE Q
Sbjct: 1365 KKVEISSLSKQLTD--------LNVQLQNSI-SLSEKEAAISSLRKQYDEEK-CELLDQV 1414
Query: 750 -----KIEGKS------------WSGEFFTCNWKMKYVTFEDEEQANLIYGNSRFTDLHS 792
K++ S WS +F WK K SRFT +
Sbjct: 1415 QDLSFKVDTLSKEKISALEQVDDWSNKF--SEWKKK--------------AQSRFTQHQN 1458
Query: 793 IIRNIQSCKEVKGRTAFN-GVSFNLL-----QFVQLLETFVGE-----------DAPLSV 835
++ +Q E+K + A+ NLL Q + + GE ++ L
Sbjct: 1459 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
Query: 836 ---SETLTSFFKEGYVETEQEKMNALEQFSQNAFQ---VRQRLLLEAI--FQKWDSDGSG 887
S+T E ++ + ++ +L + +N Q + + L++ + FQ+ +
Sbjct: 1519 ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDN 1578
Query: 888 FLDLKEVDELLYT-----YKEGMEKESMKKAKLHIQFPKPHPGHEVRLSSKQFQNYIELV 942
+KE +E + T Y E E+ KK H+ E++ + ++
Sbjct: 1579 --RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAK 1636
Query: 943 VSELRGNEDQVLESVVEFLMNALE----------RSHIESLRN--SARRKWLHQIQ---- 986
++EL+ +Q + ++ + L++ +E SH+ L R + +H ++
Sbjct: 1637 LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK 1696
Query: 987 -CAAETSGVSLEPVYSETFKALMQDAEAHG----NKKISAHISLLEENLLLPEK 1035
+ S + P ++ A + EA K IS+L+ NL EK
Sbjct: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750
Score = 37.0 bits (84), Expect = 0.14
Identities = 43/210 (20%), Positives = 86/210 (40%), Gaps = 11/210 (5%)
Query: 7 QEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEIKSQELN 66
Q++LR ++ +++ E + + + Q D+ +K NS +++ M E +Q
Sbjct: 1950 QKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKH--NSTLKQLMREFNTQLAQ 2007
Query: 67 LEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLFERMEARA 126
E + +++ + E + + L + K K E ++AR
Sbjct: 2008 KEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDARE 2067
Query: 127 QAMQQKIIDKENLKKELEKKAEKKLPR------DNLAKEWFNT---DSMTLNNTAYLLDK 177
+ M K+ D + +EL+KK ++KL + DN+ T TL + + L ++
Sbjct: 2068 EEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQ 2127
Query: 178 LLPTLVPGVENMLTQVEKKKVLTEADTPSK 207
+ +E+ L + EK T TP K
Sbjct: 2128 EFREQIHNLEDRLKKYEKNVYATTVGTPYK 2157
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 44.3 bits (103), Expect = 0.001
Identities = 62/294 (21%), Positives = 109/294 (37%), Gaps = 33/294 (11%)
Query: 472 LSANHASKTQSKLLESPDQPKLNEQRTSTPSPNP---------PEQQRGVT--------- 513
LSA+ AS+ K P P + R ++P P+P P RG T
Sbjct: 451 LSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRR 510
Query: 514 ---AEQGPQRISIEEQQQGKKPTA-EQELYIESVIEPGTHTESTLEQGSSRRLLTEQETH 569
A++ P E++ Q K+ + E+E + P T + E T
Sbjct: 511 KEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTD 570
Query: 570 RESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSR 629
T + P + + ++R +AE+ RR++ +++R E+ R
Sbjct: 571 AAVLTSPPAPAPPVTPSKPMAGTTDREEATR-LLAEK--RRQAREQRER------EEQER 621
Query: 630 RMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQE--DIGSTSQSRKDSILKSTKYGEP 687
R+ A +RE + + + EEQE + Q ++ + K + E
Sbjct: 622 RLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEA 681
Query: 688 ITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKD 741
+ E E E+ Q E+E + EE+ +RK ET +K+ K+
Sbjct: 682 RSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKE 735
Score = 40.0 bits (92), Expect = 0.017
Identities = 53/281 (18%), Positives = 105/281 (37%), Gaps = 32/281 (11%)
Query: 473 SANHASKTQSKLLESPDQPKL---NEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQG 529
+A K+QSK S ++ + + PSP P Q+ + P ++
Sbjct: 520 AAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPA 579
Query: 530 KKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPR 589
P + P T ++ + RLL E+ E+ + + ++ + +
Sbjct: 580 PAPP----------VTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDK 629
Query: 590 RVSVSEQGSSRESVAEQGSRRESIAEQD-RHKGSVAEQGSRRMSAAEQGSLRESVIEEPY 648
R+ + E+ AE+ + EQ+ R K ++ R+ ++ + S E
Sbjct: 630 RMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAER 689
Query: 649 QKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYE 708
Q+ E+ E ++QE + R + I+K T+ E + E + + + E
Sbjct: 690 QRLER----EKHFQQQEQERQERRKRLEEIMKRTRKSE----------VSETKQKQDSKE 735
Query: 709 EEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQ 749
SS P + + P K+ VQK++P + Q
Sbjct: 736 ANANGSS----PEPVKAVEARSPGLQKEAVQKEEPIPQEPQ 772
Score = 33.1 bits (74), Expect = 2.1
Identities = 35/169 (20%), Positives = 64/169 (37%), Gaps = 20/169 (11%)
Query: 487 SPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEP 546
SP P ++ TP PP + +++Q P Q G +P QE
Sbjct: 34 SPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQE--------- 84
Query: 547 GTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQ 606
ES + SR R++ + + S P V S+ +++ V +
Sbjct: 85 ----ESPSSEAKSRGPTPPAMGPRDARPPRRSSQPS-----PTAVPASDSPPTKQEVKKA 135
Query: 607 GSRRESIAE--QDRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQ 653
G R + E ++R K A++ + +LRE ++E ++ E+
Sbjct: 136 GERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEE 184
>gi|21328446 hormone-sensitive lipase [Homo sapiens]
Length = 1076
Score = 43.9 bits (102), Expect = 0.001
Identities = 58/210 (27%), Positives = 92/210 (43%), Gaps = 24/210 (11%)
Query: 478 SKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQE 537
S TQ K + +Q L +Q T P+ + E Q+ A+Q + S EE +KP +Q
Sbjct: 45 SNTQQK--PASNQRPLTQQET--PAQHDAESQKEPRAQQ--KSASQEEFLAPQKPAPQQS 98
Query: 538 LYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQG 597
YI+ V+ T E+ +QG L E T +E Q G G + E
Sbjct: 99 PYIQRVLL--TQQEAASQQGPG--LGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAE 154
Query: 598 SSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRM-----SAAEQGSLRE-----SVIEEP 647
S+ + A+ G++RE A + EQ ++ + ++QGSL E + E
Sbjct: 155 STPAAQAKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELS 214
Query: 648 YQKS--EQGPYGEII--SEEQEDIGSTSQS 673
Q+S E E + SE + D+GS+S +
Sbjct: 215 IQRSALEWKALSEWVTDSESESDVGSSSDT 244
>gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Homo
sapiens]
Length = 1194
Score = 43.1 bits (100), Expect = 0.002
Identities = 33/128 (25%), Positives = 63/128 (49%), Gaps = 7/128 (5%)
Query: 27 LTEVKELHETLQSVPDVPVK-----EDTNSVVEKAMDEIKSQELNLEGQRKISPGSIKDS 81
L +KEL E ++++P + VK E+ +V + ++ + ++N+ G RK S + S
Sbjct: 113 LKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNAS 172
Query: 82 KTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLFERMEARAQAMQQKIIDKE-NLK 140
+ E A R ++ +E E+++ + T + F ++ A QA++QKI D
Sbjct: 173 QLEQLSR-ARRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEAS 231
Query: 141 KELEKKAE 148
EL + E
Sbjct: 232 SELRENGE 239
>gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Homo
sapiens]
Length = 1352
Score = 43.1 bits (100), Expect = 0.002
Identities = 33/128 (25%), Positives = 63/128 (49%), Gaps = 7/128 (5%)
Query: 27 LTEVKELHETLQSVPDVPVK-----EDTNSVVEKAMDEIKSQELNLEGQRKISPGSIKDS 81
L +KEL E ++++P + VK E+ +V + ++ + ++N+ G RK S + S
Sbjct: 271 LKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNAS 330
Query: 82 KTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLFERMEARAQAMQQKIIDKE-NLK 140
+ E A R ++ +E E+++ + T + F ++ A QA++QKI D
Sbjct: 331 QLEQLSR-ARRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEAS 389
Query: 141 KELEKKAE 148
EL + E
Sbjct: 390 SELRENGE 397
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,830,481
Number of Sequences: 37866
Number of extensions: 2542723
Number of successful extensions: 12900
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 349
Number of HSP's that attempted gapping in prelim test: 11045
Number of HSP's gapped (non-prelim): 1759
length of query: 1503
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1388
effective length of database: 13,892,928
effective search space: 19283384064
effective search space used: 19283384064
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.