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Search of human proteins with 8923473
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
(1062 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 2154 0.0
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 1219 0.0
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 1194 0.0
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 1134 0.0
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 589 e-168
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 501 e-141
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 496 e-140
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 494 e-139
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 492 e-139
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 492 e-139
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 488 e-137
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 452 e-127
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 427 e-119
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 416 e-116
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 416 e-116
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 392 e-108
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 366 e-101
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 315 1e-85
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 315 1e-85
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 315 1e-85
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 310 6e-84
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 310 6e-84
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 261 2e-69
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 202 1e-51
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 179 2e-44
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 179 2e-44
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 179 2e-44
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 179 2e-44
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 179 2e-44
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 179 2e-44
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 2154 bits (5580), Expect = 0.0
Identities = 1062/1062 (100%), Positives = 1062/1062 (100%)
Query: 1 MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILT 60
MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILT
Sbjct: 1 MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILT 60
Query: 61 THCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDV 120
THCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDV
Sbjct: 61 THCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDV 120
Query: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSK 180
DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSK
Sbjct: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSK 180
Query: 181 EVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFK 240
EVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFK
Sbjct: 181 EVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFK 240
Query: 241 YAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGAL 300
YAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGAL
Sbjct: 241 YAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGAL 300
Query: 301 IEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFL 360
IEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFL
Sbjct: 301 IEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFL 360
Query: 361 EEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVP 420
EEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVP
Sbjct: 361 EEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVP 420
Query: 421 TCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDL 480
TCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDL
Sbjct: 421 TCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDL 480
Query: 481 RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS 540
RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS
Sbjct: 481 RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS 540
Query: 541 GVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHSTVT 600
GVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHSTVT
Sbjct: 541 GVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHSTVT 600
Query: 601 DLQELLGCLYESQEEELVKEVMAQFKEISLHLNAVDVVPSSFCVKHCRNLQKMSLQVIKE 660
DLQELLGCLYESQEEELVKEVMAQFKEISLHLNAVDVVPSSFCVKHCRNLQKMSLQVIKE
Sbjct: 601 DLQELLGCLYESQEEELVKEVMAQFKEISLHLNAVDVVPSSFCVKHCRNLQKMSLQVIKE 660
Query: 661 NLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILC 720
NLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILC
Sbjct: 661 NLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILC 720
Query: 721 EQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRH 780
EQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRH
Sbjct: 721 EQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRH 780
Query: 781 PECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKC 840
PECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKC
Sbjct: 781 PECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKC 840
Query: 841 FLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQ 900
FLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQ
Sbjct: 841 FLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQ 900
Query: 901 TLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLW 960
TLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLW
Sbjct: 901 TLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLW 960
Query: 961 LWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKI 1020
LWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKI
Sbjct: 961 LWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKI 1020
Query: 1021 DDFNDELNKLLEEIEEKNPQLIIDTEKHHPWAERPSSHDFMI 1062
DDFNDELNKLLEEIEEKNPQLIIDTEKHHPWAERPSSHDFMI
Sbjct: 1021 DDFNDELNKLLEEIEEKNPQLIIDTEKHHPWAERPSSHDFMI 1062
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 1219 bits (3153), Expect = 0.0
Identities = 656/1060 (61%), Positives = 767/1060 (72%), Gaps = 56/1060 (5%)
Query: 2 VSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTT 61
++S Q+ + LQ LLEQL++DEL FK L+ F L LQK P EV++ADGK+L EIL
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 62 HCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPL-DV 120
W+ A++ + E+M+ +L + AK E+ E + + P L D
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQ------------VQEIDNPELGDA 108
Query: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKS--WPGD 178
+E E K G+K N K +WK+ W GD
Sbjct: 109 EEDSELAKP---------------------GEKEGWRNSME-----KQSLVWKNTFWQGD 142
Query: 179 SKEVQV-MAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH 237
+ R + IPF NPR YTVVL+GPAG+GKTTLA+K MLDW + NL
Sbjct: 143 IDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSP 202
Query: 238 KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAP 297
+YAFYLSC+ELSR+GPCSFAEL+ +DWPELQDDIP ILAQA++ILFV+DG DEL P
Sbjct: 203 TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPP 262
Query: 298 GALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVE 357
GALI+DICGDWEKKKPVPVLLGSLL R MLP+AALLVTTRPRALRDL++LA++PIY+RVE
Sbjct: 263 GALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVE 322
Query: 358 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 417
GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED
Sbjct: 323 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 382
Query: 418 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQE 477
PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQ SV HREDLERLGVQE
Sbjct: 383 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE 442
Query: 478 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQK 537
SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY LEKEE EDRDGH WDIGDVQK
Sbjct: 443 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQK 502
Query: 538 LLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHS 597
LLSG ERL+NPDLIQ G++ FGLANEKRAKELEATFGCRMSPDIKQELL+C
Sbjct: 503 LLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKP 562
Query: 598 -TVTDLQELLGCLYESQEEELVKEVMAQFKEISLHL-NAVDVVPSSFCVKHCRNLQKMSL 655
+VTDL+E+LGCLYESQEEEL K V+A FKEIS+HL N +V+ SF +KHC++LQK+SL
Sbjct: 563 LSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSL 622
Query: 656 QVIKENLPENVTASESDAEVER---------SQDDQHMLPFWTDLCSIFGSNKDLMGLAI 706
QV K EN E D E ER ++ D L WTD CS+F SN +L L +
Sbjct: 623 QVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEV 682
Query: 707 NDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGND 766
SFLS S VRILC+ + TCHLQ+V KN++P A+R+ CLA G KT+T+LTL G+
Sbjct: 683 KQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHI 742
Query: 767 QDD--MFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELL 824
+ + M LC++LR+ +CNL+YL L AT +QWA+ L+ NQSL + LS N LL
Sbjct: 743 EWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLL 802
Query: 825 DEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTG 884
DEGA LLY T+ PK FLQ LSLENC LTEA+CKDLAAVLVVS++LTHLCLAKNPIG+TG
Sbjct: 803 DEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTG 862
Query: 885 VKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKF 944
VKFLCEGL YP+CKLQTLVL C IT GC L++ LQE SL LDL +N I +G+
Sbjct: 863 VKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWI 921
Query: 945 LCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFE 1004
LC+AL P CNL+ L LW CS+ PF C+ L SAL NQ L TLDLGQN L SG+ LF
Sbjct: 922 LCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFG 981
Query: 1005 TLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLIID 1044
L +G+L+ LRLK + N E+ KLLEE++EKNP+L ID
Sbjct: 982 VLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTID 1021
Score = 63.9 bits (154), Expect = 8e-10
Identities = 59/201 (29%), Positives = 85/201 (42%), Gaps = 1/201 (0%)
Query: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLC 748
DL ++ +K L L + + + + V+ LCE ++ C LQ +V + S R L
Sbjct: 837 DLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLS 896
Query: 749 LALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
AL+ ++T L L N LC+ L +P CNL++L L SCS L AL
Sbjct: 897 EALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALL 956
Query: 809 VNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSR 868
NQ L ++L N L G L+ LR L+ L L+ K L V +
Sbjct: 957 SNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNP 1016
Query: 869 ELTHLCLAKNPIGNTGVKFLC 889
+LT C A F C
Sbjct: 1017 KLTIDCNASGATAPPCCDFFC 1037
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform 1
[Homo sapiens]
Length = 1009
Score = 1194 bits (3088), Expect = 0.0
Identities = 647/1051 (61%), Positives = 755/1051 (71%), Gaps = 66/1051 (6%)
Query: 2 VSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTT 61
++S Q+ + LQ LLEQL++DEL FK L+ F L LQK P EV++ADGK+L EIL
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 62 HCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPL-DV 120
W+ A++ + E+M+ +L + AK E+ E + + P L D
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQ------------VQEIDNPELGDA 108
Query: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKS--WPGD 178
+E E K G+K N K +WK+ W GD
Sbjct: 109 EEDSELAKP---------------------GEKEGWRNSME-----KQSLVWKNTFWQGD 142
Query: 179 SKEVQV-MAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH 237
+ R + IPF NPR YTVVL+GPAG+GKTTLA+K MLDW + NL
Sbjct: 143 IDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSP 202
Query: 238 KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAP 297
+YAFYLSC+ELSR+GPCSFAEL+ +DWPELQDDIP ILAQA++ILFV+DG DEL P
Sbjct: 203 TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPP 262
Query: 298 GALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVE 357
GALI+DICGDWEKKKPVPVLLGSLL R MLP+AALLVTTRPRALRDL++LA++PIY+RVE
Sbjct: 263 GALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVE 322
Query: 358 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 417
GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED
Sbjct: 323 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 382
Query: 418 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQE 477
PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQ SV HREDLERLGVQE
Sbjct: 383 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE 442
Query: 478 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQK 537
SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY LEKEE EDRDGH WDIGDVQK
Sbjct: 443 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQK 502
Query: 538 LLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHS 597
LLSG ERL+NPDLIQ G++ FGLANEKRAKELEATFGCRMSPDIKQELL+C
Sbjct: 503 LLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKP 562
Query: 598 -TVTDLQELLGCLYESQEEELVKEVMAQFKEISLHL-NAVDVVPSSFCVKHCRNLQKMSL 655
+VTDL+E+LGCLYESQEEEL K V+A FKEIS+HL N +V+ SF +KHC++LQK+SL
Sbjct: 563 LSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSL 622
Query: 656 QVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASL 715
QV K EN E D E E SN +L L + SFLS S
Sbjct: 623 QVAKGVFLENYMDFELDIEFE-------------------SSNSNLKFLEVKQSFLSDSS 663
Query: 716 VRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQDD--MFPA 773
VRILC+ + TCHLQ+V KN++P A+R+ CLA G KT+T+LTL G+ + + M
Sbjct: 664 VRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLM 723
Query: 774 LCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYT 833
LC++LR+ +CNL+YL L AT +QWA+ L+ NQSL + LS N LLDEGA LLY
Sbjct: 724 LCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYK 783
Query: 834 TLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLR 893
T+ PK FLQ LSLENC LTEA+CKDLAAVLVVS++LTHLCLAKNPIG+TGVKFLCEGL
Sbjct: 784 TMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLS 843
Query: 894 YPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPL 953
YP+CKLQTLVL C IT GC L++ LQE SL LDL +N I +G+ LC+AL P
Sbjct: 844 YPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALENPN 902
Query: 954 CNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTL 1013
CNL+ L LW CS+ PF C+ L SAL NQ L TLDLGQN L SG+ LF L +G+L
Sbjct: 903 CNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSL 962
Query: 1014 RTLRLKIDDFNDELNKLLEEIEEKNPQLIID 1044
+ LRLK + N E+ KLLEE++EKNP+L ID
Sbjct: 963 KILRLKTYETNLEIKKLLEEVKEKNPKLTID 993
Score = 63.9 bits (154), Expect = 8e-10
Identities = 59/201 (29%), Positives = 85/201 (42%), Gaps = 1/201 (0%)
Query: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLC 748
DL ++ +K L L + + + + V+ LCE ++ C LQ +V + S R L
Sbjct: 809 DLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLS 868
Query: 749 LALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
AL+ ++T L L N LC+ L +P CNL++L L SCS L AL
Sbjct: 869 EALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALL 928
Query: 809 VNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSR 868
NQ L ++L N L G L+ LR L+ L L+ K L V +
Sbjct: 929 SNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNP 988
Query: 869 ELTHLCLAKNPIGNTGVKFLC 889
+LT C A F C
Sbjct: 989 KLTIDCNASGATAPPCCDFFC 1009
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 1134 bits (2933), Expect = 0.0
Identities = 610/977 (62%), Positives = 710/977 (72%), Gaps = 56/977 (5%)
Query: 2 VSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTT 61
++S Q+ + LQ LLEQL++DEL FK L+ F L LQK P EV++ADGK+L EIL
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 62 HCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPL-DV 120
W+ A++ + E+M+ +L + AK E+ E + + P L D
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQ------------VQEIDNPELGDA 108
Query: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKS--WPGD 178
+E E K G+K N K +WK+ W GD
Sbjct: 109 EEDSELAKP---------------------GEKEGWRNSME-----KQSLVWKNTFWQGD 142
Query: 179 SKEVQV-MAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH 237
+ R + IPF NPR YTVVL+GPAG+GKTTLA+K MLDW + NL
Sbjct: 143 IDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSP 202
Query: 238 KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAP 297
+YAFYLSC+ELSR+GPCSFAEL+ +DWPELQDDIP ILAQA++ILFV+DG DEL P
Sbjct: 203 TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPP 262
Query: 298 GALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVE 357
GALI+DICGDWEKKKPVPVLLGSLL R MLP+AALLVTTRPRALRDL++LA++PIY+RVE
Sbjct: 263 GALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVE 322
Query: 358 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 417
GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED
Sbjct: 323 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 382
Query: 418 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQE 477
PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQ SV HREDLERLGVQE
Sbjct: 383 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE 442
Query: 478 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQK 537
SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY LEKEE EDRDGH WDIGDVQK
Sbjct: 443 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQK 502
Query: 538 LLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHS 597
LLSG ERL+NPDLIQ G++ FGLANEKRAKELEATFGCRMSPDIKQELL+C
Sbjct: 503 LLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKP 562
Query: 598 -TVTDLQELLGCLYESQEEELVKEVMAQFKEISLHL-NAVDVVPSSFCVKHCRNLQKMSL 655
+VTDL+E+LGCLYESQEEEL K V+A FKEIS+HL N +V+ SF +KHC++LQK+SL
Sbjct: 563 LSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSL 622
Query: 656 QVIKENLPENVTASESDAEVER---------SQDDQHMLPFWTDLCSIFGSNKDLMGLAI 706
QV K EN E D E ER ++ D L WTD CS+F SN +L L +
Sbjct: 623 QVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEV 682
Query: 707 NDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGND 766
SFLS S VRILC+ + TCHLQ+V KN++P A+R+ CLA G KT+T+LTL G+
Sbjct: 683 KQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHI 742
Query: 767 QDD--MFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELL 824
+ + M LC++LR+ +CNL+YL L AT +QWA+ L+ NQSL + LS N LL
Sbjct: 743 EWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLL 802
Query: 825 DEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTG 884
DEGA LLY T+ PK FLQ LSLENC LTEA+CKDLAAVLVVS++LTHLCLAKNPIG+TG
Sbjct: 803 DEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTG 862
Query: 885 VKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKF 944
VKFLCEGL YP+CKLQTLVL C IT GC L++ LQE SL LDL +N I +G+
Sbjct: 863 VKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWI 921
Query: 945 LCEALRKPLCNLRCLWL 961
LC+AL P CNL+ L L
Sbjct: 922 LCQALENPNCNLKHLRL 938
Score = 43.9 bits (102), Expect = 8e-04
Identities = 36/126 (28%), Positives = 57/126 (45%), Gaps = 1/126 (0%)
Query: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLC 748
DL ++ +K L L + + + + V+ LCE ++ C LQ +V + S R L
Sbjct: 837 DLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLS 896
Query: 749 LALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
AL+ ++T L L N LC+ L +P CNL++L L + + L E
Sbjct: 897 EALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKE 956
Query: 809 VNQSLT 814
N LT
Sbjct: 957 KNPKLT 962
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 589 bits (1518), Expect = e-168
Identities = 399/1120 (35%), Positives = 586/1120 (52%), Gaps = 142/1120 (12%)
Query: 9 FNLQALLEQLSQDELSKFK-YLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYW 67
F L LE+L+++EL+ FK +L T H L P EV KA + L ++ +
Sbjct: 13 FGLLLYLEELNKEELNTFKLFLKETMEPEHGLT--PWNEVKKARREDLANLMKKYYPGEK 70
Query: 68 VEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDVDEMLERF 127
SL++F KM+ DL ERAK+E+ +A ++G
Sbjct: 71 AWSVSLKIFGKMNLKDLCERAKEEINWSAQ---------TIG------------------ 103
Query: 128 KTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMW--KSWPGDSKEVQ-- 183
+A+A ET+ + +E G + NR +K KF W KS G ++
Sbjct: 104 PDDAKA-GETQED-----QEAVLGDGTEYRNR----IKEKFCITWDKKSLAGKPEDFHHG 153
Query: 184 VMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH-KFKYA 242
+ + K+L + V G VVL G AG+GKTTL +K MLDWAE +L +FKY
Sbjct: 154 IAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYV 213
Query: 243 FYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGALIE 302
FYL+ RE+++L SFA+L+ +DWP + I I+ Q +LF+ID FDEL A
Sbjct: 214 FYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEF 273
Query: 303 DICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEE 362
+C DW ++ PV L+ SLL +VMLP+A+LLVTTR + L+ L + Y+ + G E+
Sbjct: 274 ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSED 333
Query: 363 DRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTC 422
R Y + F D+ AM+ F ++SN LF + P VCW CT LK QMEKG D TC
Sbjct: 334 AREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTC 393
Query: 423 LTRTGLFLRFLCSRF----------PQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLER 472
T T LF ++ S F P AQ LR L +AA+G+W T V +RE+L R
Sbjct: 394 QTTTALFTCYISSLFTPVDGGSPSLPNQAQ----LRRLCQVAAKGIWTMTYVFYRENLRR 449
Query: 473 LGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDI 532
LG+ +SD+ F+D +I+++D + CY F HL Q+F A+FY L K E +
Sbjct: 450 LGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYML-KGSWEAGNPSCQPF 508
Query: 533 GDVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRC-DIS 591
D++ LL ++P L Q + FGL NE R K+LE TF C+MS IK +LL+C ++
Sbjct: 509 EDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVL 567
Query: 592 CKGGHS-TVTDLQELLGCLYESQEEELVKEVMAQFKEISLHL-NAVDVVPSSFCVKHCRN 649
+S + EL CLYE+Q++ + + M F ++++++ + ++ SSFC+KHCR
Sbjct: 568 GNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIHLLVSSFCLKHCRC 627
Query: 650 LQKMSL--------QVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDL 701
L+ + L +++K +LP N + D + W DLCS+ +N+ L
Sbjct: 628 LRTIRLSVTVVFEKKILKTSLPTN------------TWDGDRITHCWQDLCSVLHTNEHL 675
Query: 702 MGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLT 761
L + S L S + IL ++ C LQ+++ K I+ D +++ +L +K + +L
Sbjct: 676 RELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHLD 735
Query: 762 LQGND-QDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSD 820
L+G+D D+ +LCE L+HPEC L+ L L SC+ T ++S AL +QSL +NLS
Sbjct: 736 LKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLST 795
Query: 821 NELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPI 880
N LLD+G +LL LRHPKC+L+RLSLE+C LTEA C+ L+ L+ ++ LTHLCLA N +
Sbjct: 796 NNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVL 855
Query: 881 GNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDL-TKLLQEKS-------------- 925
G+ GVK + + L++ +C L++LVL C TS L T LL KS
Sbjct: 856 GDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDN 915
Query: 926 --SLLC----------------------------------------LDLGLNHIGVKGMK 943
LLC LDLG N + G+K
Sbjct: 916 GVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVK 975
Query: 944 FLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLF 1003
LC+ALR P CN++ L L C + C+DL SAL CN+ L+ ++L QN LG G+ L+
Sbjct: 976 ILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLY 1035
Query: 1004 ETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043
+ L L+ L L + F++E KLLE + NP LII
Sbjct: 1036 KVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLII 1075
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 501 bits (1289), Expect = e-141
Identities = 346/1060 (32%), Positives = 530/1060 (50%), Gaps = 95/1060 (8%)
Query: 1 MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILT 60
M +S F L LE+L ++E KFK + +L EL++IP EV KA ++L +L
Sbjct: 1 MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLI 60
Query: 61 THCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDV 120
H + +L++F+ +MD RK L + + R
Sbjct: 61 KHYEEQQAWNITLRIFQ---KMD-------------------RKDLCMKVMR-------- 90
Query: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSK 180
E +T+T + K KF +W S
Sbjct: 91 ---------ERTGYTKTY----------------------QAHAKQKFSRLWSSKSVTEI 119
Query: 181 ----EVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLI 236
E +V E L P+ G TV++ GP G+GKTTL KLM+ W+++ +
Sbjct: 120 HLYFEEEVKQEECDHLDRLFAPKEA-GKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIF 178
Query: 237 H-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGA 295
+F Y FY CREL L P S A+L+ R+WP+ I I++Q ++LFVID F+EL
Sbjct: 179 RDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQG 238
Query: 296 APGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIR 355
D+CGD +K+PV VLL SLL + MLP+A+LL+ +P ++LR +
Sbjct: 239 GLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQ 298
Query: 356 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 415
GF E DR YF F D +AM AF L+R + LF + P +CWI+CT+LK +M+KG
Sbjct: 299 PRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKG 358
Query: 416 EDPVPTCLTRTGLFLRFLCSRF-PQGA-----QLRGALRTLSLLAAQGLWAQTSVLHRED 469
+D TC + T ++ F+ + F P+GA Q + L+ L LAA+G+W T +D
Sbjct: 359 KDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDD 418
Query: 470 LERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHT 529
L R GV ++D+ L IL + + Y F+H+ Q+F ALFY L+ +
Sbjct: 419 LRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPA-- 476
Query: 530 WDIGDVQKLL-SGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRC 588
+ VQ+LL + E+ R I G + GL N+K ++L+A FG ++S +IKQ++ +C
Sbjct: 477 --VRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQC 534
Query: 589 --DISCKGGHSTVTDLQELLGCLYESQEEELVKEVMAQFKEISLHL-NAVDVVPSSFCVK 645
+ +G D + CL+E Q+ VK+ + +E + H+ + VD+V S++C+K
Sbjct: 535 LKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLK 594
Query: 646 HCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLA 705
+C +L+K+ V +NV E E S + L W +CS+ ++ L L
Sbjct: 595 YCSSLRKLCFSV------QNVFKKED----EHSSTSDYSLICWHHICSVLTTSGHLRELQ 644
Query: 706 INDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYL--TLQ 763
+ DS LS S C Q+ +C LQ++ N+S + L L + YL TL
Sbjct: 645 VQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLT 704
Query: 764 GNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNEL 823
+DD+ +LC+ L +P N++ L LV+C + L+ L N+ LT +N+S N+L
Sbjct: 705 KLSRDDI-RSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL 763
Query: 824 LDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNT 883
D G LL L P L L L CHL+E C+ ++ +L+ ++ + +L L+ N + +
Sbjct: 764 -DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDE 822
Query: 884 GVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMK 943
G+K LCE L++P+C L +L L C IT+ GC DL L +L L +G N IG G++
Sbjct: 823 GLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQ 882
Query: 944 FLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLF 1003
LC AL C L L L C + C+DL S L+C+++L L+L N L +GV +L
Sbjct: 883 LLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLC 942
Query: 1004 ETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043
E L L+ L L+ DF++E LL EE+NP L I
Sbjct: 943 EALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982
Score = 129 bits (325), Expect = 1e-29
Identities = 94/252 (37%), Positives = 123/252 (48%), Gaps = 21/252 (8%)
Query: 691 LCSIFGSNKDLMGLAINDSFLSASLVRILCEQIAS-DT---------CHLQRVVFKNISP 740
L + +NK L L ++ + L V +LCE + S DT CHL + IS
Sbjct: 743 LAGLLTNNKKLTYLNVSCNQLDTG-VPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISE 801
Query: 741 ADAHRNLCLALRGHKTVTYLTLQGND-QDDMFPALCEVLRHPECNLRYLGLVSCSATTQQ 799
L +K+V YL L N +D+ LCE L+HP+C L L LV C T
Sbjct: 802 M---------LLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAG 852
Query: 800 WADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKD 859
DL+ AL NQ+L + + NE+ D G +LL L H C L+ L LE C LT CKD
Sbjct: 853 CEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKD 912
Query: 860 LAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTK 919
LA+VL S+ L L L N + +TGV LCE LR+PEC LQ L L D + LT
Sbjct: 913 LASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTA 972
Query: 920 LLQEKSSLLCLD 931
+ +L D
Sbjct: 973 EEERNPNLTITD 984
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/133 (30%), Positives = 60/133 (45%), Gaps = 2/133 (1%)
Query: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLC 748
DL S SN++L L I + + V++LC + C L+ + + + ++L
Sbjct: 855 DLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLA 914
Query: 749 LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807
L KT+ L L N D LCE LRHPEC L+ LGL + A L+
Sbjct: 915 SVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEE 974
Query: 808 EVNQSLTCVNLSD 820
E N +LT + D
Sbjct: 975 ERNPNLTITDDCD 987
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 496 bits (1277), Expect = e-140
Identities = 336/1036 (32%), Positives = 517/1036 (49%), Gaps = 48/1036 (4%)
Query: 15 LEQLSQDELSKFKYLITTFSLAH-------ELQKIPHKEVDKADGKQLVEILTTHCDSYW 67
L L Q +L +FK + L +IP + AD L +L H
Sbjct: 21 LMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHFPKGQ 80
Query: 68 VEMASLQVFEKMHRMDLSERAKDEVRE-AALKSFNKRKPLSLGITRKERPPLDVDEMLER 126
L +F+ M+ L E+ + E++E + L + + +
Sbjct: 81 AWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQDP 140
Query: 127 FKTEAQAFTETKGNVICLGKEVFKGKKPDK----DNRCRYI--LKTKFREMWK--SWPGD 178
+ E E GNV G + ++P+ D+R +Y +K + E W SWP D
Sbjct: 141 NQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPKD 200
Query: 179 SKEVQVMA----ERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDN 234
++ + E + L+ + R + T+VL G AG+GKTTLA + ML WA
Sbjct: 201 HVYIRNTSKDEHEELQRLLDPNRTRAQ----AQTIVLVGRAGVGKTTLAMQAMLHWANGV 256
Query: 235 LIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDEL 293
L +F Y FYLSC ++ + +FAEL+ DWP+ I ++Q K+LF+IDGF+E+
Sbjct: 257 LFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEI 316
Query: 294 --GAAPGALIED--ICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAE 349
+ ++D C DW ++ PV +L SLL + ++P A LL+T + +RDL+
Sbjct: 317 IISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLV 376
Query: 350 EPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLK 409
P ++++ GF +D R YF+RHF D + + + +R N LF SAP VCW VC+ LK
Sbjct: 377 NPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLK 436
Query: 410 LQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGA------QLRGALRTLSLLAAQGLWAQTS 463
+ D T T L+ F + F G R L LA +GLW+
Sbjct: 437 QPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNF 496
Query: 464 VLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEE 523
++ED E G++ + + +IL++ GC +F HLSFQ+F A+ + LE E
Sbjct: 497 TFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLE--EPR 554
Query: 524 DRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQ 583
+ H+ +++ LL V + + FGL N+ A+ELE T C++SP + +
Sbjct: 555 EFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVME 614
Query: 584 ELLRC--DISCKGGHSTVTDLQELLGCLYESQEEELVKEVMAQFKEISLH-LNAVDVVPS 640
ELL+ ++ S + L CL+ESQEE+ K+++ + E+ L+ L ++ S
Sbjct: 615 ELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQAS 674
Query: 641 SFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKD 700
SFC+KHC+ L K+ L V L E D E+ + + W +CS +N++
Sbjct: 675 SFCLKHCKRLNKLRLSVSSHIL-------ERDLEILETSKFDSRMHAWNSICSTLVTNEN 727
Query: 701 LMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYL 760
L L +++S L AS V+ LC + + C +Q++ K+++P ++L +AL+G+ +T+L
Sbjct: 728 LHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHL 787
Query: 761 TLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSD 820
N P + + LRH CNL+YL L C+ + DL+L L Q +T + L
Sbjct: 788 NFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGF 847
Query: 821 NELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPI 880
N L D+G KLL L HPKC L+RL L C L CK L+ L+ +R LTHL L+KN +
Sbjct: 848 NRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSL 907
Query: 881 GNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVK 940
+ GVKFLCE L P+ LQ+L L C T +GC +L L ++ LDLG N +
Sbjct: 908 RDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDD 967
Query: 941 GMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVK 1000
G+K LCEAL KP L L L C++ C+ L S LS ++SLV L+L N L + GVK
Sbjct: 968 GVKLLCEAL-KPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVK 1026
Query: 1001 MLFETLTCSSGTLRTL 1016
ML + L S+ L+ L
Sbjct: 1027 MLCKALKKSTCRLQKL 1042
Score = 119 bits (297), Expect = 2e-26
Identities = 80/245 (32%), Positives = 122/245 (49%), Gaps = 2/245 (0%)
Query: 782 ECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCF 841
E +L L + W + L N++L ++LS+++L K L L++P+C
Sbjct: 697 ERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCK 756
Query: 842 LQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQT 901
+Q+L+ ++ E +DL L + +LTHL + N +G T V + + LR+ C L+
Sbjct: 757 VQKLTCKSV-TPEWVLQDLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKY 814
Query: 902 LVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWL 961
L L C++++ C DL L + L LG N + G+K LC AL P C L L L
Sbjct: 815 LCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLEL 874
Query: 962 WGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKID 1021
W C + +C+ L AL N+SL L+L +N L GVK L E L G L++L L
Sbjct: 875 WFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGC 934
Query: 1022 DFNDE 1026
F E
Sbjct: 935 SFTRE 939
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 494 bits (1272), Expect = e-139
Identities = 335/1066 (31%), Positives = 541/1066 (50%), Gaps = 98/1066 (9%)
Query: 1 MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILT 60
M S F L L++L ++E KFK L+ EL+ IP E+ KA + + ++L
Sbjct: 1 MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLD 60
Query: 61 THCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDV 120
H +L +F +++R KD +A + NK P RK
Sbjct: 61 KHYPGKQAWEVTLNLFLQINR-------KDLWTKAQEEMRNKLNPY-----RKH------ 102
Query: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSK 180
M E F+ + T C ++ + ++E K+ +
Sbjct: 103 --MKETFQLIWEKET------------------------CLHVPEHFYKETMKNEYKELN 136
Query: 181 EVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH-KF 239
+ A R +TVVL GP G+GKTTL +K+MLDWAE NL +F
Sbjct: 137 DAYTAAAR-----------------RHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRF 179
Query: 240 KYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGA 299
+ F+L+ E++ + S EL+ RDWPE + I I +Q +ILF++DGF++L
Sbjct: 180 TFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNL-Q 238
Query: 300 LIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGF 359
L D+ DW +++P+P++L SLL + MLP+++LL+ A++ + P I++ GF
Sbjct: 239 LKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGF 298
Query: 360 LEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPV 419
E ++++YF FG++ +A++ F +R N LF L P CW+VCT +K ++E+GED
Sbjct: 299 SESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLE 358
Query: 420 PTCLTRTGLFLRFLCSRFPQGAQL------RGALRTLSLLAAQGLWAQTSVLHREDLERL 473
T L+ FL + F G+Q R L++L LAA+G+W T V DL R
Sbjct: 359 INSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRN 418
Query: 474 GVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIG 533
G+ ES+ +++ +L++ C++F+HL Q+F A+FY L++ +++ IG
Sbjct: 419 GLSESEGVMWVGMRLLQR---RGDCFAFMHLCIQEFCAAMFYLLKRPKDDPNPA----IG 471
Query: 534 DVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDIS-- 591
+ +L+ L Q G + FG++ E+ LE +FG +S D+KQE+ +C S
Sbjct: 472 SITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLS 531
Query: 592 -CKGGHSTVTDLQELLGCLYESQEEELVKEVMAQFKEISLHLNAVD-VVPSSFCVKHCRN 649
C+ + QEL L+E+QE+E V +VM F+E+ +++ ++ +V +SFC+KHC++
Sbjct: 532 QCEADREAIA-FQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQH 590
Query: 650 LQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDS 709
L + + V EN+ +S D L +W +LCS+F +NK+ L + ++
Sbjct: 591 LTTLRMCV------ENIFPDDSGC----ISDYNEKLVYWRELCSMFITNKNFQILDMENT 640
Query: 710 FLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGND--Q 767
L + ILC+ +A C L++++F ++ L A+ + + L+L G Q
Sbjct: 641 SLDDPSLAILCKALAQPVCKLRKLIFTSVYFGH-DSELFKAVLHNPHLKLLSLYGTSLSQ 699
Query: 768 DDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEG 827
D+ LCE L+HP C + L L C +++ D++ L N L ++L +N L DEG
Sbjct: 700 SDI-RHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEG 758
Query: 828 AKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKF 887
LL L+H C L+RL L C LT +C ++ VL+ S+ L+ L L N + + GV
Sbjct: 759 MTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVAS 818
Query: 888 LCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCE 947
LC L++P C ++ L L C +TSD C D+ +L L L LG N IG G++ LC
Sbjct: 819 LCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCA 878
Query: 948 ALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLT 1007
AL+ P C L CL L C I C+D+ +AL ++L +L+L L + V +L E L+
Sbjct: 879 ALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALS 938
Query: 1008 CSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLIIDTEKHHPWAE 1053
L+ L L F++E K+L +EEK P L I H PW +
Sbjct: 939 HPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI---SHGPWID 981
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 492 bits (1266), Expect = e-139
Identities = 351/1068 (32%), Positives = 530/1068 (49%), Gaps = 82/1068 (7%)
Query: 11 LQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEM 70
L LE L +L KFK + + +P + +KAD L ++
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 71 ASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKER------------PPL 118
++ +F ++R DL E+AK + E S N R I +++ +
Sbjct: 70 MAVWIFAAINRRDLYEKAKRD--EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127
Query: 119 DVDEMLERFKTEAQAFTETKGNVI-----CLGKEVFKGKKPDKDNRCRYILKTKFREMWK 173
+ +M + ++ + + + ++ I LG+ V K+ + + + RE
Sbjct: 128 SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187
Query: 174 SWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAED 233
G +K + KM + F P +TVV G AG+GKT LA+K+MLDWA
Sbjct: 188 LAIGKTKTCESPVSPIKMELLFDPDDEHSEPV-HTVVFQGAAGIGKTILARKMMLDWASG 246
Query: 234 NLIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDE 292
L +F Y FY+ CRE+S + S +L+ P+ I I+ + +ILF++DGFDE
Sbjct: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
Query: 293 LGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPI 352
L A I +C DW+K + +LL SL+ + +LP+A+LL+TTRP AL L+ L + P
Sbjct: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 353 YIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQM 412
++ + GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QM
Sbjct: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
Query: 413 EKGEDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQTSVLHR 467
E G+ T T T +++ FL S P+G L L L LAA G+W Q +
Sbjct: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
Query: 468 EDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDG 527
DL G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E+E G
Sbjct: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKE----G 542
Query: 528 HTWDIG--------DVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSP 579
T G DV LL + LI + FGL N++R LE C++S
Sbjct: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
Query: 580 DIKQELLR-CDISCKGGHSTVTDLQ-ELLGCLYESQEEELVKEVMAQFKEISLHLNA-VD 636
I+ ELL+ ++ K + Q EL CLYE QEE+ V+ M F +I ++L+ +D
Sbjct: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
Query: 637 VVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFG 696
+ SSFC+++C ++ +SL + N+P+ E E ++ +H+
Sbjct: 663 HMVSSFCIENCHRVESLSLGFL-HNMPKE--------EEEEEKEGRHL------------ 701
Query: 697 SNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKT 756
D++ + S +A ++ + S C R L L ++
Sbjct: 702 ---DMVQCVLPSSSHAACSHGLVNSHLTSSFC----------------RGLFSVLSTSQS 742
Query: 757 VTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTC 815
+T L L N D LCE L+HP CN+R L L C + + D+SL L NQ L
Sbjct: 743 LTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVE 802
Query: 816 VNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCL 875
++LSDN L D G +LL L+H C L++L L +C LT A C+DLA+VL S LT L +
Sbjct: 803 LDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYV 862
Query: 876 AKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLN 935
+N +G++GV LCE + P+C LQ L L N +TS C L+ +L +L L L N
Sbjct: 863 GENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGN 922
Query: 936 HIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLG 995
+G KG+K LCE L P C L+ L L C++ C DL + L+ +QSL L LG N LG
Sbjct: 923 TLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLG 982
Query: 996 SSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043
GV M E L S L+ L L FN E LE ++E+ P+L +
Sbjct: 983 DLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 691 LCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLCL 749
L S+ +N++L L + + L +++LCE + C LQ + N + + +L
Sbjct: 904 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 963
Query: 750 ALRGHKTVTYLTLQGNDQDDMFPAL-CEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
L +++ L+L ND D+ + CEVL+ C L+ LGL + + L E
Sbjct: 964 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQE 1023
Query: 809 VNQSLTCV 816
LT V
Sbjct: 1024 EKPELTVV 1031
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 492 bits (1266), Expect = e-139
Identities = 351/1068 (32%), Positives = 530/1068 (49%), Gaps = 82/1068 (7%)
Query: 11 LQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEM 70
L LE L +L KFK + + +P + +KAD L ++
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 71 ASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKER------------PPL 118
++ +F ++R DL E+AK + E S N R I +++ +
Sbjct: 70 MAVWIFAAINRRDLYEKAKRD--EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127
Query: 119 DVDEMLERFKTEAQAFTETKGNVI-----CLGKEVFKGKKPDKDNRCRYILKTKFREMWK 173
+ +M + ++ + + + ++ I LG+ V K+ + + + RE
Sbjct: 128 SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187
Query: 174 SWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAED 233
G +K + KM + F P +TVV G AG+GKT LA+K+MLDWA
Sbjct: 188 LAIGKTKTCESPVSPIKMELLFDPDDEHSEPV-HTVVFQGAAGIGKTILARKMMLDWASG 246
Query: 234 NLIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDE 292
L +F Y FY+ CRE+S + S +L+ P+ I I+ + +ILF++DGFDE
Sbjct: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
Query: 293 LGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPI 352
L A I +C DW+K + +LL SL+ + +LP+A+LL+TTRP AL L+ L + P
Sbjct: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 353 YIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQM 412
++ + GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QM
Sbjct: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
Query: 413 EKGEDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQTSVLHR 467
E G+ T T T +++ FL S P+G L L L LAA G+W Q +
Sbjct: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
Query: 468 EDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDG 527
DL G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E+E G
Sbjct: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKE----G 542
Query: 528 HTWDIG--------DVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSP 579
T G DV LL + LI + FGL N++R LE C++S
Sbjct: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
Query: 580 DIKQELLR-CDISCKGGHSTVTDLQ-ELLGCLYESQEEELVKEVMAQFKEISLHLNA-VD 636
I+ ELL+ ++ K + Q EL CLYE QEE+ V+ M F +I ++L+ +D
Sbjct: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
Query: 637 VVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFG 696
+ SSFC+++C ++ +SL + N+P+ E E ++ +H+
Sbjct: 663 HMVSSFCIENCHRVESLSLGFL-HNMPKE--------EEEEEKEGRHL------------ 701
Query: 697 SNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKT 756
D++ + S +A ++ + S C R L L ++
Sbjct: 702 ---DMVQCVLPSSSHAACSHGLVNSHLTSSFC----------------RGLFSVLSTSQS 742
Query: 757 VTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTC 815
+T L L N D LCE L+HP CN+R L L C + + D+SL L NQ L
Sbjct: 743 LTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVE 802
Query: 816 VNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCL 875
++LSDN L D G +LL L+H C L++L L +C LT A C+DLA+VL S LT L +
Sbjct: 803 LDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYV 862
Query: 876 AKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLN 935
+N +G++GV LCE + P+C LQ L L N +TS C L+ +L +L L L N
Sbjct: 863 GENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGN 922
Query: 936 HIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLG 995
+G KG+K LCE L P C L+ L L C++ C DL + L+ +QSL L LG N LG
Sbjct: 923 TLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLG 982
Query: 996 SSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043
GV M E L S L+ L L FN E LE ++E+ P+L +
Sbjct: 983 DLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 691 LCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLCL 749
L S+ +N++L L + + L +++LCE + C LQ + N + + +L
Sbjct: 904 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 963
Query: 750 ALRGHKTVTYLTLQGNDQDDMFPAL-CEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
L +++ L+L ND D+ + CEVL+ C L+ LGL + + L E
Sbjct: 964 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQE 1023
Query: 809 VNQSLTCV 816
LT V
Sbjct: 1024 EKPELTVV 1031
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 488 bits (1256), Expect = e-137
Identities = 354/1071 (33%), Positives = 536/1071 (50%), Gaps = 62/1071 (5%)
Query: 11 LQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEM 70
L LE+L EL KFK + T + E KIP ++KA ++ ++L TH
Sbjct: 13 LSTYLEELEAVELKKFKLYLGTATELGE-GKIPWGSMEKAGPLEMAQLLITHFGPEEAWR 71
Query: 71 ASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDVDEMLERFKTE 130
+L FE+++R DL ER + RE ++ P SLG + L+V + R K
Sbjct: 72 LALSTFERINRKDLWERGQ---REDLVRDTPPGGPSSLG--NQSTCLLEVSLVTPR-KDP 125
Query: 131 AQAFTETKGNVICL--GKEVFKGKKPDKDNRCRYILKTKF--------REMWKSWPGDSK 180
+ + + L + G+ + +R +L K +++ + G ++
Sbjct: 126 QETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHAR 185
Query: 181 EVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH-KF 239
V A K+ F P P TVV+ G AG+GK+ LA K+MLDWA+ L +F
Sbjct: 186 TVGHQASPIKIETLFEPDEERPEP-PRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRF 244
Query: 240 KYAFYLSCRELSRLGP-CSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPG 298
Y FY++CRE+++ CS +L+F WPE + ++ ++LF+IDGFDEL +
Sbjct: 245 DYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFH 304
Query: 299 ALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEG 358
C WE+K+P +LL SL+ + +LP+ +LL+TTRP AL L L E P ++ + G
Sbjct: 305 DPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILG 364
Query: 359 FLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDP 418
F E +R+ YF ++F + +QA + F +R N LF + P VCW+VCT L+ Q+E G
Sbjct: 365 FSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLL 424
Query: 419 VPTCLTRTGLFLRFLCSRF---PQGAQLRGA--LRTLSLLAAQGLWAQTSVLHREDLERL 473
T T T +++ +L S P +L+ R L LAA GLW Q + +DL +
Sbjct: 425 RQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKH 484
Query: 474 GVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIG 533
G+ D+ FL+ +I ++D + YSFIHLSFQ+F A++Y L++ E G
Sbjct: 485 GLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGE-----GGAGPDQ 539
Query: 534 DVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCK 593
DV +LL+ L + FGL NE+ LE + ++SP IK +LL+ I K
Sbjct: 540 DVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQW-IQSK 598
Query: 594 GGHSTVTDLQ---ELLGCLYESQEEELVKEVMAQFKEISLH--LNAVDVVPSSFCVKHCR 648
T Q E CLYE QEEE +++ ++ F+ I + + ++ + SSFC+K CR
Sbjct: 599 AQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCR 658
Query: 649 NLQKMSLQVIKENLPENVTASESDAEVERSQDDQHML------------PFWTDLCSIFG 696
+ Q + L T S + R H L + L +
Sbjct: 659 SAQVLHLY--------GATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALC 710
Query: 697 SNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLCLALRGHK 755
+N +L+ L++ + L + V++LC+ + C LQ + K + A +L AL +K
Sbjct: 711 TNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANK 770
Query: 756 TVTYLTLQGNDQDDMFPA---LCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQS 812
+T + L GN FP LCE LRHP+C L+ + L C + +++ L N
Sbjct: 771 NLTRMDLSGNGVG--FPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH 828
Query: 813 LTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTH 872
L ++L+ N L D G +LL LRHP C L+ L L+ C LT A C +LA+ L V++ L
Sbjct: 829 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE 888
Query: 873 LCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDL 932
L L+ N +G+ GV LCEGLR+P CKLQTL L C + S C L+ +LQ +L LDL
Sbjct: 889 LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL 948
Query: 933 GLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN 992
N +G G+ L E L+ P C L+ LWL C + +CE+L L NQ+L L L N
Sbjct: 949 SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN 1008
Query: 993 PLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043
LG +GV++L + L+ LR L L D N + L + P L I
Sbjct: 1009 ALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
Score = 76.3 bits (186), Expect = 1e-13
Identities = 63/188 (33%), Positives = 89/188 (47%), Gaps = 4/188 (2%)
Query: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQ--RVVFKNISPADAHRNL 747
+L S N+ L L ++ + L V +LCE + TC LQ R+ + A A L
Sbjct: 875 ELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSA-ACEGL 933
Query: 748 CLALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLA 806
+ L+ + + L L ND D L E L+HP C L+ L L SC T + +L
Sbjct: 934 SVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFT 993
Query: 807 LEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVV 866
L +NQ+LT + L++N L D G +LL L HP C L+ L L L + LAA+ V
Sbjct: 994 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVT 1053
Query: 867 SRELTHLC 874
L C
Sbjct: 1054 KPYLDIGC 1061
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 452 bits (1164), Expect = e-127
Identities = 332/1068 (31%), Positives = 522/1068 (48%), Gaps = 85/1068 (7%)
Query: 9 FNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWV 68
+ LQ L +L ++E FK L+ S IP E++ A+ + L +L + +
Sbjct: 63 YGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLA 122
Query: 69 EMASLQVFEKMHRMDLSERAKDEVR-------EAALKSFNKRKPLSLGI---------TR 112
S+ +FE M+ LSE+A+D+++ EA + K GI T
Sbjct: 123 WATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATA 182
Query: 113 KERPPLDVDEMLER-----FKTEAQAFT---ETKGNVICLGKEVFKGKKPDKDNRCRYIL 164
E ++ + +E+ +TE Q + E +G +E +G D + +++
Sbjct: 183 AETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEE--QGHGGDTWDYKSHVM 240
Query: 165 KTKF------REMWKSWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLG 218
TKF R +++ D E+Q +A + PR TVVL+G +G+G
Sbjct: 241 -TKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPR--------TVVLHGKSGIG 291
Query: 219 KTTLAQKLMLDWAEDNLIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHIL 277
K+ LA++++L WA+ L F Y F+L RE+ R S E + R+WP+ Q + I+
Sbjct: 292 KSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIM 351
Query: 278 AQARKILFVIDGFDELGAAPGALIED--ICGDWEKKKPVPVLLGSLLNRVMLPKAALLVT 335
++ ++LF+IDGFD+LG+ L D +C DW +K+P L+ SLL +V+LP++ L+VT
Sbjct: 352 SRPERLLFIIDGFDDLGSV---LNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVT 408
Query: 336 TRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 395
R L+ P Y+ V G E R L E Q + + +N L
Sbjct: 409 VRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQC 468
Query: 396 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-------QLRGAL 447
PAV ++C L+LQ GE P T TGL F+ + P+G + R L
Sbjct: 469 QVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVL 528
Query: 448 RTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQ 507
+ +A +G+W + SV +DL G+ ES+LR +IL D + Y+F HLS Q
Sbjct: 529 KRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQ 588
Query: 508 QFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERL-RNPDLIQAGY---------YS 557
F AL+Y LE E E + VE+ R+ +L QAG+ +
Sbjct: 589 DFCAALYYVLEGLEIEPALCPLY-----------VEKTKRSMELKQAGFHIHSLWMKRFL 637
Query: 558 FGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHSTVT---DLQELLGCLYESQE 614
FGL +E + LE GC + +KQ+LL +S G T D + CL+E+Q+
Sbjct: 638 FGLVSEDVRRPLEVLLGCPVPLGVKQKLLHW-VSLLGQQPNATTPGDTLDAFHCLFETQD 696
Query: 615 EELVKEVMAQFKEISLHLNA-VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDA 673
+E V+ + F+E+ L +N +D++ SSFC++HC L+K+ + V K P + +A
Sbjct: 697 KEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDV-KGIFPRDESAEACPV 755
Query: 674 EVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRV 733
+D + W D CS+ G++ L L + S L+ ++ LC ++ TC +Q +
Sbjct: 756 VPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTL 815
Query: 734 VFKNISPADAHRNLCLALRGHKTVTYLTLQGND--QDDMFPALCEVLRHPECNLRYLGLV 791
+F+N ++L + ++ + L L G ++D+ A CE L+HP+C L L L
Sbjct: 816 MFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMA-CEALKHPKCLLESLRLD 874
Query: 792 SCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCH 851
C T + +S L + SL ++L+ N++ D+G L LR +C LQ+L LE+C
Sbjct: 875 CCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCG 934
Query: 852 LTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITS 911
+T C+ LA+ LV +R LTHLCL+ N +GN GV LC +R P C LQ L+L C + +
Sbjct: 935 ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994
Query: 912 DGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSC 971
GC L L S L L L +N + G+K LCE +R+P C+L+ L L C + C
Sbjct: 995 AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054
Query: 972 EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLK 1019
E L +S ++ L +LDL N LG GV L E L + L L LK
Sbjct: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLK 1102
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 427 bits (1098), Expect = e-119
Identities = 279/872 (31%), Positives = 447/872 (51%), Gaps = 34/872 (3%)
Query: 156 KDNRCRYILKTKFREMWK--SWPGDSKEVQVMA-ERYKMLIP-FSNPRVLPGPFSYTVVL 211
K R + + KF +W +WPG+ ++ R++ +P P+ G TV +
Sbjct: 149 KIRRYKSNVMEKFFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAI 208
Query: 212 YGPAGLGKTTLAQKLMLDWAEDNLI-HKFKYAFYLSCRELSRLGPCSFAELVFRDWPELQ 270
G G+GKT LA+K+M +WA + HK AFY C+E+++ SF+EL+ + WP Q
Sbjct: 209 QGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQ 268
Query: 271 DDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKA 330
D + I+++ ++L ++DGF+EL + +ED+ DW +K P VLL SLL++ MLP+A
Sbjct: 269 DLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEA 328
Query: 331 ALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAA 390
LL+ R + + + L + P + + GF ++ YF +FG ++ + N
Sbjct: 329 TLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTI 388
Query: 391 LFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ------LR 444
LF + P VCW+VC+ LK QME+G + +C T +F+R++ S FP A+ +
Sbjct: 389 LFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQ 448
Query: 445 GALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHL 504
L L LAA +W + VL +EDLE + ++ + FL ILR+ + Y F +
Sbjct: 449 AQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLV 508
Query: 505 SFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFGLANEK 564
+FQ+F ALFY L + ++ H ++Q+L++ R L G + FG NE
Sbjct: 509 TFQEFFAALFYVL-CFPQRLKNFHVLSHVNIQRLIAS-PRGSKSYLSHMGLFLFGFLNEA 566
Query: 565 RAKELEATFGCRMSPDIKQELL-------RCDISCKGGHSTVTDLQELLGCLYESQEEEL 617
A +E +F C++S K++LL +CD G + + +L CL+E +EE
Sbjct: 567 CASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPG-----SGVPQLFYCLHEIREEAF 621
Query: 618 VKEVMAQFKEISLHL-NAVDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVE 676
V + + + ++ L + N +V S+FC+K C+ L ++ L V N S S
Sbjct: 622 VSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTL-NFMNVWKLSSSSHPGS 680
Query: 677 RSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFK 736
+ + + +W DLCS+F +N L L + +S L ++ L + C LQ+++ +
Sbjct: 681 EAPESNGLHRWWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLR 740
Query: 737 NISPADAHRNLCLALRGHKTVTYLTLQGND-QDDMFPALCEVLRHPECNLRYLGLVSCSA 795
++ +++L L G++ + YL +Q + + LC VLR P C L+ L L C A
Sbjct: 741 RVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLA 800
Query: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855
T + W DL L+ N L + L N L + GA L L+RLS+ENC+LT+
Sbjct: 801 TPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQ------LERLSIENCNLTQL 854
Query: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915
C+ LA+ L S+ LTHL LA+N + + G K + L + C LQ LVL CD+T + C
Sbjct: 855 TCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQ 914
Query: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLC 975
D+ L + +L LDL N + G+ LCEAL+ P C L+ L L C C+ +
Sbjct: 915 DMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMA 974
Query: 976 SALSCNQSLVTLDLGQNPLGSSGVKMLFETLT 1007
S L NQ L LDL +N +G G+ L E +
Sbjct: 975 SMLRKNQHLRHLDLSKNAIGVYGILTLCEAFS 1006
Score = 111 bits (278), Expect = 3e-24
Identities = 94/298 (31%), Positives = 136/298 (45%), Gaps = 8/298 (2%)
Query: 745 RNLCLALRGHKTVTYLTLQGNDQDDMF-PALCEVLRHPECNLRYLGLVSCSATTQQWADL 803
++LC + + LT+ + F AL LRHP+C L+ L L ++T DL
Sbjct: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDL 751
Query: 804 SLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAV 863
L NQ L + + E+ + KLL LR P+C LQ L LE+C T DL
Sbjct: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
Query: 864 LVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQE 923
L + L L L KN + N G +L +L+ L + NC++T C L L++
Sbjct: 812 LQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQ 865
Query: 924 KSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQS 983
L L L N + +G K + AL C L+ L L C + C+D+ SAL N++
Sbjct: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925
Query: 984 LVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQL 1041
L +LDL N L GV +L E L TL+ L L+ F + + + KN L
Sbjct: 926 LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHL 983
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 416 bits (1070), Expect = e-116
Identities = 307/970 (31%), Positives = 474/970 (48%), Gaps = 61/970 (6%)
Query: 11 LQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEM 70
L LE L +L KFK + + +P + +KAD L ++
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 71 ASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKER------------PPL 118
++ +F ++R DL E+AK + E S N R I +++ +
Sbjct: 70 MAVWIFAAINRRDLYEKAKRD--EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127
Query: 119 DVDEMLERFKTEAQAFTETKGNVI-----CLGKEVFKGKKPDKDNRCRYILKTKFREMWK 173
+ +M + ++ + + + ++ I LG+ V K+ + + + RE
Sbjct: 128 SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187
Query: 174 SWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAED 233
G +K + KM + F P +TVV G AG+GKT LA+K+MLDWA
Sbjct: 188 LAIGKTKTCESPVSPIKMELLFDPDDEHSEPV-HTVVFQGAAGIGKTILARKMMLDWASG 246
Query: 234 NLIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDE 292
L +F Y FY+ CRE+S + S +L+ P+ I I+ + +ILF++DGFDE
Sbjct: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
Query: 293 LGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPI 352
L A I +C DW+K + +LL SL+ + +LP+A+LL+TTRP AL L+ L + P
Sbjct: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 353 YIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQM 412
++ + GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QM
Sbjct: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
Query: 413 EKGEDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQTSVLHR 467
E G+ T T T +++ FL S P+G L L L LAA G+W Q +
Sbjct: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
Query: 468 EDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDG 527
DL G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E+E G
Sbjct: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKE----G 542
Query: 528 HTWDIG--------DVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSP 579
T G DV LL + LI + FGL N++R LE C++S
Sbjct: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
Query: 580 DIKQELLR-CDISCKGGHSTVTDLQ-ELLGCLYESQEEELVKEVMAQFKEISLHLNA-VD 636
I+ ELL+ ++ K + Q EL CLYE QEE+ V+ M F +I ++L+ +D
Sbjct: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
Query: 637 VVPSSFCVKHCRNLQKMSLQVIKENLPEN----------------VTASESDAEVERSQD 680
+ SSFC+++C ++ +SL + N+P+ V S S A
Sbjct: 663 HMVSSFCIENCHRVESLSLGFL-HNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLV 721
Query: 681 DQHML-PFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS 739
+ H+ F L S+ +++ L L ++D+ L +R+LCE + C+++R+
Sbjct: 722 NSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCG 781
Query: 740 PA-DAHRNLCLALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATT 797
+ + ++ L L ++ + L L N D LC L+H CNL+ L LV+ T+
Sbjct: 782 LSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTS 841
Query: 798 QQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANC 857
+ LS L NQ+LT + L N L D+G KLL L HP C LQ L L+NC+LT C
Sbjct: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901
Query: 858 KDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDL 917
DL+ +L S+ L L L N +G+ GV CE L+ C LQ L L + L
Sbjct: 902 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 961
Query: 918 TKLLQEKSSL 927
L +EK L
Sbjct: 962 ETLQEEKPEL 971
Score = 165 bits (417), Expect = 2e-40
Identities = 104/275 (37%), Positives = 148/275 (53%), Gaps = 3/275 (1%)
Query: 769 DMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGA 828
DM + H C+ GLV+ T+ L L +QSLT ++LSDN L D G
Sbjct: 702 DMVQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGM 758
Query: 829 KLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFL 888
++L TL+HP C ++RL L C L+ C D++ VL +++L L L+ N +G+ G++ L
Sbjct: 759 RVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLL 818
Query: 889 CEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEA 948
C GL++ C L+ L L N +TS C L+ +L +L L L N +G KG+K LCE
Sbjct: 819 CVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEG 878
Query: 949 LRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTC 1008
L P C L+ L L C++ C DL + L+ +QSL L LG N LG GV M E L
Sbjct: 879 LLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQ 938
Query: 1009 SSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043
S L+ L L FN E LE ++E+ P+L +
Sbjct: 939 QSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 691 LCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLCL 749
L S+ +N++L L + + L +++LCE + C LQ + N + + +L
Sbjct: 847 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 906
Query: 750 ALRGHKTVTYLTLQGNDQDDMFPAL-CEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
L +++ L+L ND D+ + CEVL+ C L+ LGL + + L E
Sbjct: 907 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQE 966
Query: 809 VNQSLTCV 816
LT V
Sbjct: 967 EKPELTVV 974
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 416 bits (1070), Expect = e-116
Identities = 309/972 (31%), Positives = 478/972 (49%), Gaps = 65/972 (6%)
Query: 11 LQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEM 70
L LE L +L KFK + + +P + +KAD L ++
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 71 ASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKER------------PPL 118
++ +F ++R DL E+AK + E S N R I +++ +
Sbjct: 70 MAVWIFAAINRRDLYEKAKRD--EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127
Query: 119 DVDEMLERFKTEAQAFTETKGNVI-----CLGKEVFKGKKPDKDNRCRYILKTKFREMWK 173
+ +M + ++ + + + ++ I LG+ V K+ + + + RE
Sbjct: 128 SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187
Query: 174 SWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAED 233
G +K + KM + F P +TVV G AG+GKT LA+K+MLDWA
Sbjct: 188 LAIGKTKTCESPVSPIKMELLFDPDDEHSEPV-HTVVFQGAAGIGKTILARKMMLDWASG 246
Query: 234 NLIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDE 292
L +F Y FY+ CRE+S + S +L+ P+ I I+ + +ILF++DGFDE
Sbjct: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
Query: 293 LGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPI 352
L A I +C DW+K + +LL SL+ + +LP+A+LL+TTRP AL L+ L + P
Sbjct: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 353 YIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQM 412
++ + GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QM
Sbjct: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
Query: 413 EKGEDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQTSVLHR 467
E G+ T T T +++ FL S P+G L L L LAA G+W Q +
Sbjct: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
Query: 468 EDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDG 527
DL G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E+E G
Sbjct: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKE----G 542
Query: 528 HTWDIG--------DVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSP 579
T G DV LL + LI + FGL N++R LE C++S
Sbjct: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
Query: 580 DIKQELLR-CDISCKGGHSTVTDLQ-ELLGCLYESQEEELVKEVMAQFKEISLHLNA-VD 636
I+ ELL+ ++ K + Q EL CLYE QEE+ V+ M F +I ++L+ +D
Sbjct: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
Query: 637 VVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWT------- 689
+ SSFC+++C ++ +SL + N+P+ E + E Q +LP +
Sbjct: 663 HMVSSFCIENCHRVESLSLGFL-HNMPKE--EEEEEKEGRHLDMVQCVLPSSSHAACSHG 719
Query: 690 ------------DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKN 737
D+ + SN+ L+ L ++D+ L +R+LC + C+L+++ +
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
Query: 738 ISPADA-HRNLCLALRGHKTVTYLTLQGNDQDDMFPA-LCEVLRHPECNLRYLGLVSCSA 795
A ++L L ++T L + N D A LCE ++P+CNL+ LGLV+
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
Query: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855
T+ + LS L NQ+LT + L N L D+G KLL L HP C LQ L L+NC+LT
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
Query: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915
C DL+ +L S+ L L L N +G+ GV CE L+ C LQ L L +
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
Query: 916 DLTKLLQEKSSL 927
L L +EK L
Sbjct: 960 ALETLQEEKPEL 971
Score = 176 bits (445), Expect = 1e-43
Identities = 110/275 (40%), Positives = 149/275 (54%), Gaps = 3/275 (1%)
Query: 769 DMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGA 828
DM + H C+ GL C + + D+SL L NQ L ++LSDN L D G
Sbjct: 702 DMVQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGI 758
Query: 829 KLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFL 888
+LL L+H C L++L L +C LT A C+DLA+VL S LT L + +N +G++GV L
Sbjct: 759 RLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAIL 818
Query: 889 CEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEA 948
CE + P+C LQ L L N +TS C L+ +L +L L L N +G KG+K LCE
Sbjct: 819 CEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEG 878
Query: 949 LRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTC 1008
L P C L+ L L C++ C DL + L+ +QSL L LG N LG GV M E L
Sbjct: 879 LLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQ 938
Query: 1009 SSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043
S L+ L L FN E LE ++E+ P+L +
Sbjct: 939 QSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 691 LCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLCL 749
L S+ +N++L L + + L +++LCE + C LQ + N + + +L
Sbjct: 847 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 906
Query: 750 ALRGHKTVTYLTLQGNDQDDMFPAL-CEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
L +++ L+L ND D+ + CEVL+ C L+ LGL + + L E
Sbjct: 907 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQE 966
Query: 809 VNQSLTCV 816
LT V
Sbjct: 967 EKPELTVV 974
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 392 bits (1006), Expect = e-108
Identities = 300/952 (31%), Positives = 456/952 (47%), Gaps = 82/952 (8%)
Query: 11 LQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEM 70
L LE L +L KFK + + +P + +KAD L ++
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 71 ASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKER------------PPL 118
++ +F ++R DL E+AK + E S N R I +++ +
Sbjct: 70 MAVWIFAAINRRDLYEKAKRD--EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127
Query: 119 DVDEMLERFKTEAQAFTETKGNVI-----CLGKEVFKGKKPDKDNRCRYILKTKFREMWK 173
+ +M + ++ + + + ++ I LG+ V K+ + + + RE
Sbjct: 128 SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187
Query: 174 SWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAED 233
G +K + KM + F P +TVV G AG+GKT LA+K+MLDWA
Sbjct: 188 LAIGKTKTCESPVSPIKMELLFDPDDEHSEPV-HTVVFQGAAGIGKTILARKMMLDWASG 246
Query: 234 NLIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDE 292
L +F Y FY+ CRE+S + S +L+ P+ I I+ + +ILF++DGFDE
Sbjct: 247 TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
Query: 293 LGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPI 352
L A I +C DW+K + +LL SL+ + +LP+A+LL+TTRP AL L+ L + P
Sbjct: 307 LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
Query: 353 YIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQM 412
++ + GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QM
Sbjct: 367 HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
Query: 413 EKGEDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQTSVLHR 467
E G+ T T T +++ FL S P+G L L L LAA G+W Q +
Sbjct: 427 ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
Query: 468 EDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDG 527
DL G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E+E G
Sbjct: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKE----G 542
Query: 528 HTWDIG--------DVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSP 579
T G DV LL + LI + FGL N++R LE C++S
Sbjct: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
Query: 580 DIKQELLR-CDISCKGGHSTVTDLQ-ELLGCLYESQEEELVKEVMAQFKEISLHLNA-VD 636
I+ ELL+ ++ K + Q EL CLYE QEE+ V+ M F +I ++L+ +D
Sbjct: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
Query: 637 VVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFG 696
+ SSFC+++C ++ +SL + N+P+ E E ++ +H+
Sbjct: 663 HMVSSFCIENCHRVESLSLGFL-HNMPKE--------EEEEEKEGRHL------------ 701
Query: 697 SNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKT 756
D++ + S +A C C L +IS L L ++
Sbjct: 702 ---DMVQCVLPSSSHAA------CSH-GLGRCGLSHECCFDIS---------LVLSSNQK 742
Query: 757 VTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTC 815
+ L L N D LC L+H CNL+ L LV+ T+ + LS L NQ+LT
Sbjct: 743 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTH 802
Query: 816 VNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCL 875
+ L N L D+G KLL L HP C LQ L L+NC+LT C DL+ +L S+ L L L
Sbjct: 803 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 862
Query: 876 AKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSL 927
N +G+ GV CE L+ C LQ L L + L L +EK L
Sbjct: 863 GNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPEL 914
Score = 137 bits (345), Expect = 5e-32
Identities = 81/193 (41%), Positives = 109/193 (56%), Gaps = 3/193 (1%)
Query: 769 DMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGA 828
DM + H C+ GL C + + D+SL L NQ L ++LSDN L D G
Sbjct: 702 DMVQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGI 758
Query: 829 KLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFL 888
+LL L+H C L++L L N LT C L++VL ++ LTHL L N +G+ G+K L
Sbjct: 759 RLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLL 818
Query: 889 CEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEA 948
CEGL +P+CKLQ L L NC++TS C DL+ LL SL L LG N +G G+ CE
Sbjct: 819 CEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEV 878
Query: 949 LRKPLCNLRCLWL 961
L++ C L+ L L
Sbjct: 879 LKQQSCLLQNLGL 891
Score = 124 bits (311), Expect = 5e-28
Identities = 75/197 (38%), Positives = 107/197 (54%)
Query: 847 LENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWN 906
L C L+ C D++ VL +++L L L+ N +G+ G++ LC GL++ C L+ L L N
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 907 CDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSI 966
+TS C L+ +L +L L L N +G KG+K LCE L P C L+ L L C++
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 967 PPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDE 1026
C DL + L+ +QSL L LG N LG GV M E L S L+ L L FN E
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYE 899
Query: 1027 LNKLLEEIEEKNPQLII 1043
LE ++E+ P+L +
Sbjct: 900 TKSALETLQEEKPELTV 916
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 691 LCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLCL 749
L S+ +N++L L + + L +++LCE + C LQ + N + + +L
Sbjct: 790 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 849
Query: 750 ALRGHKTVTYLTLQGNDQDDMFPAL-CEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
L +++ L+L ND D+ + CEVL+ C L+ LGL + + L E
Sbjct: 850 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQE 909
Query: 809 VNQSLTCV 816
LT V
Sbjct: 910 EKPELTVV 917
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 366 bits (940), Expect = e-101
Identities = 267/923 (28%), Positives = 426/923 (46%), Gaps = 55/923 (5%)
Query: 151 GKKPDKDNRCRYILKTKFREMWKSWPGDSKEVQ----VMAERYKMLIPFSNPRVLPGPFS 206
G++ C+ +++ KF W+S + V ++ + +L + +
Sbjct: 87 GRRNRNQEACKAVMRRKFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANN 146
Query: 207 YTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKF-KYAFYLSCRELSRLGPCSFAELVFRD 265
V L G GKT + +L W + + Y +L+ E++++ S AEL+ +D
Sbjct: 147 LNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKD 206
Query: 266 WPELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRV 325
WP+ Q I IL+ +K+LF+++ D + +C + +K P+PVLL SLL R
Sbjct: 207 WPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRK 266
Query: 326 MLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELM 385
M P L+++RP +++ +E R YF F D +A A +L+
Sbjct: 267 MAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLV 326
Query: 386 RSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLR- 444
+ L L +CWI CT LK QM+KG D C T T L FL A L
Sbjct: 327 HEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTA 386
Query: 445 -----GALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCY 499
G L+ L LLAA GL+ T EDL +G E+D+ + +IL K Y
Sbjct: 387 NQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRY 446
Query: 500 SFIHLSFQQFLTALFYTL----------EKEEEEDRDGHTWDIGDVQKLLSGVERLRNPD 549
FIHL+ Q+F TA+ + + +E +E R+ ++ D
Sbjct: 447 KFIHLNVQEFCTAIAFLMAVPNYLIPSGSREYKEKREQYS-------------------D 487
Query: 550 LIQAGYYSFGLANEKRAKELEATFGCR--MSPDIKQELLRCDISCKGGHSTVTDLQELLG 607
Q + FGL N R K LE +FG + M K + +T L
Sbjct: 488 FNQVFTFIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFY 547
Query: 608 CLYESQEEELVKEVMAQFKEISLHLNA-VDVVPSSFCVKHCRNLQ--KMSLQVIKENLPE 664
CLYE++EEE VK ++ E++++L + D++ S +C+ +C +L+ K+S+Q I +N
Sbjct: 548 CLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEP 607
Query: 665 NVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIA 724
+ + S + L +W ++CS+F + + L L I D+ L+ RIL + +
Sbjct: 608 LIRPTASQMK---------SLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALE 658
Query: 725 SDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQD-DMFPALCEVLRHPEC 783
+C L+ + +S A +L AL ++++TYL++ +MF L ++L P C
Sbjct: 659 HSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTC 718
Query: 784 NLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQ 843
+ +L L+ C + +++ L SL + LS N L +G +L L HP C L
Sbjct: 719 QISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLI 778
Query: 844 RLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLV 903
L L C LTE C L VL+ S L L L N + N GV + L +P C+L+ L
Sbjct: 779 SLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELH 838
Query: 904 LWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWG 963
L C +SD C + ++ L L++G N I GM+ LC LR P C L + L
Sbjct: 839 LSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEE 898
Query: 964 CSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDF 1023
C + C L S L+ N++L L+L QN LG+ GV L E+L L+ + L +
Sbjct: 899 CMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGL 958
Query: 1024 NDELNKLLEEIEEKNPQLIIDTE 1046
N + +LL ++E+ P LI +E
Sbjct: 959 NTQTQQLLMTVKERKPSLIFLSE 981
Score = 31.2 bits (69), Expect = 5.4
Identities = 25/106 (23%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 1 MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILT 60
M S F+L LE LS E FK + L +L + P ++ K ++L +L
Sbjct: 1 MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTK---EELANVLP 57
Query: 61 THCDSYWVEMASLQVFEKMHRMDLSER--AKDEVREAALKSFNKRK 104
+ ++ +F M + DL + + + A K+ +RK
Sbjct: 58 ISYEGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRRK 103
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 315 bits (808), Expect = 1e-85
Identities = 221/663 (33%), Positives = 351/663 (52%), Gaps = 26/663 (3%)
Query: 209 VVLYGPAGLGKTTLAQKLMLDWAEDNLI-HKFKYAFYLSCRELSRLGPCSFAELVFRDWP 267
V+L G AG+GK+TLA+++ W L +F++ FY SCREL++ S AEL+ +D
Sbjct: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
Query: 268 ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVML 327
I IL++ ++LF++DG DE G ++C W + +P LLGSLL + +L
Sbjct: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
Query: 328 PKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRS 387
P+A+ L+T R AL++L E+ ++ V GF E R+ YF R+F DE QA+RAF L++S
Sbjct: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
Query: 388 NAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGAL 447
N L+ L P V W+ CT L QM++ E T T T L L +L Q L L
Sbjct: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL-QAQPLGPQL 568
Query: 448 RTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQ 507
R L LAA+G+W + ++ +DL + G+ + + FL IL++ + YSFIHL FQ
Sbjct: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLS-YSFIHLCFQ 627
Query: 508 QFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS--GVERLRNPDLIQAGYYSFGLANEKR 565
+F A+ Y L E+E+ R H+ I D++K L G+ L + + GL +++
Sbjct: 628 EFFAAMSYVL--EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTR---FLLGLLSDEG 682
Query: 566 AKELEATFGCRMSP--DIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMA 623
+E+E F CR+S ++ Q + + + HS E L CLYE++ + + +VMA
Sbjct: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQ-PHSL-----ESLHCLYETRNKTFLTQVMA 736
Query: 624 QFKEISLHLNA-VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQ 682
F+E+ + + ++++ +FC+K R+++K+ L E T S + + R
Sbjct: 737 HFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL---IEGRQHRSTWSPTMVVLFRWVPVT 793
Query: 683 HMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PA 741
+W L S+ ++L L ++ + LS S V+ LC+ + C L+ + A
Sbjct: 794 D--AYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 742 DAHRNLCLALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQW 800
+ ++L LR ++T+T L L N D LC+ LR P C L+ L LVSC T+
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 801 ADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDL 860
DL+ L + SL ++L N L D G +LL LRHP C L RL L+ L++ ++L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 861 AAV 863
A+
Sbjct: 972 RAL 974
Score = 128 bits (322), Expect = 2e-29
Identities = 80/198 (40%), Positives = 108/198 (54%), Gaps = 2/198 (1%)
Query: 733 VVFKNISPADAHRNLCLA-LRGHKTVTYLTLQGND-QDDMFPALCEVLRHPECNLRYLGL 790
V+F+ + DA+ + + L+ + + L L GN +LC+ LR P C L L L
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 791 VSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENC 850
C T + DL+ L NQ+LT ++LS N L D GAK L LR P C LQRL L +C
Sbjct: 845 AGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Query: 851 HLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDIT 910
LT C+DLA+VL S L L L +N + + GV+ LCEGLR+P CKL L L ++
Sbjct: 905 GLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
Query: 911 SDGCCDLTKLLQEKSSLL 928
+ +L L QEK LL
Sbjct: 965 DEMRQELRALEQEKPQLL 982
Score = 126 bits (316), Expect = 1e-28
Identities = 76/192 (39%), Positives = 109/192 (56%)
Query: 852 LTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITS 911
+T+A + L +VL V+R L L L+ N + ++ VK LC+ LR P C L+TL L C +T+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 912 DGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSC 971
+ C DL L+ +L LDL N + G K LC+ LR+P C L+ L L C + C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 972 EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLL 1031
+DL S LS + SL LDL QN L GV++L E L + L L L +DE+ + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 1032 EEIEEKNPQLII 1043
+E++ PQL+I
Sbjct: 972 RALEQEKPQLLI 983
Score = 125 bits (313), Expect = 3e-28
Identities = 70/161 (43%), Positives = 91/161 (56%)
Query: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855
T W L L+V ++L ++LS N L K L TLR P+C L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915
+CKDLA L ++ LT L L+ N + + G K LC+ LR P CKLQ L L +C +TSD C
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNL 956
DL +L SL LDL N++ G++ LCE LR P C L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 315 bits (808), Expect = 1e-85
Identities = 221/663 (33%), Positives = 351/663 (52%), Gaps = 26/663 (3%)
Query: 209 VVLYGPAGLGKTTLAQKLMLDWAEDNLI-HKFKYAFYLSCRELSRLGPCSFAELVFRDWP 267
V+L G AG+GK+TLA+++ W L +F++ FY SCREL++ S AEL+ +D
Sbjct: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
Query: 268 ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVML 327
I IL++ ++LF++DG DE G ++C W + +P LLGSLL + +L
Sbjct: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
Query: 328 PKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRS 387
P+A+ L+T R AL++L E+ ++ V GF E R+ YF R+F DE QA+RAF L++S
Sbjct: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
Query: 388 NAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGAL 447
N L+ L P V W+ CT L QM++ E T T T L L +L Q L L
Sbjct: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL-QAQPLGPQL 568
Query: 448 RTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQ 507
R L LAA+G+W + ++ +DL + G+ + + FL IL++ + YSFIHL FQ
Sbjct: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLS-YSFIHLCFQ 627
Query: 508 QFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS--GVERLRNPDLIQAGYYSFGLANEKR 565
+F A+ Y L E+E+ R H+ I D++K L G+ L + + GL +++
Sbjct: 628 EFFAAMSYVL--EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTR---FLLGLLSDEG 682
Query: 566 AKELEATFGCRMSP--DIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMA 623
+E+E F CR+S ++ Q + + + HS E L CLYE++ + + +VMA
Sbjct: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQ-PHSL-----ESLHCLYETRNKTFLTQVMA 736
Query: 624 QFKEISLHLNA-VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQ 682
F+E+ + + ++++ +FC+K R+++K+ L E T S + + R
Sbjct: 737 HFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL---IEGRQHRSTWSPTMVVLFRWVPVT 793
Query: 683 HMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PA 741
+W L S+ ++L L ++ + LS S V+ LC+ + C L+ + A
Sbjct: 794 D--AYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 742 DAHRNLCLALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQW 800
+ ++L LR ++T+T L L N D LC+ LR P C L+ L LVSC T+
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 801 ADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDL 860
DL+ L + SL ++L N L D G +LL LRHP C L RL L+ L++ ++L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 861 AAV 863
A+
Sbjct: 972 RAL 974
Score = 128 bits (322), Expect = 2e-29
Identities = 80/198 (40%), Positives = 108/198 (54%), Gaps = 2/198 (1%)
Query: 733 VVFKNISPADAHRNLCLA-LRGHKTVTYLTLQGND-QDDMFPALCEVLRHPECNLRYLGL 790
V+F+ + DA+ + + L+ + + L L GN +LC+ LR P C L L L
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 791 VSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENC 850
C T + DL+ L NQ+LT ++LS N L D GAK L LR P C LQRL L +C
Sbjct: 845 AGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Query: 851 HLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDIT 910
LT C+DLA+VL S L L L +N + + GV+ LCEGLR+P CKL L L ++
Sbjct: 905 GLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
Query: 911 SDGCCDLTKLLQEKSSLL 928
+ +L L QEK LL
Sbjct: 965 DEMRQELRALEQEKPQLL 982
Score = 126 bits (316), Expect = 1e-28
Identities = 76/192 (39%), Positives = 109/192 (56%)
Query: 852 LTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITS 911
+T+A + L +VL V+R L L L+ N + ++ VK LC+ LR P C L+TL L C +T+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 912 DGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSC 971
+ C DL L+ +L LDL N + G K LC+ LR+P C L+ L L C + C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 972 EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLL 1031
+DL S LS + SL LDL QN L GV++L E L + L L L +DE+ + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 1032 EEIEEKNPQLII 1043
+E++ PQL+I
Sbjct: 972 RALEQEKPQLLI 983
Score = 125 bits (313), Expect = 3e-28
Identities = 70/161 (43%), Positives = 91/161 (56%)
Query: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855
T W L L+V ++L ++LS N L K L TLR P+C L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915
+CKDLA L ++ LT L L+ N + + G K LC+ LR P CKLQ L L +C +TSD C
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNL 956
DL +L SL LDL N++ G++ LCE LR P C L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 315 bits (808), Expect = 1e-85
Identities = 221/663 (33%), Positives = 351/663 (52%), Gaps = 26/663 (3%)
Query: 209 VVLYGPAGLGKTTLAQKLMLDWAEDNLI-HKFKYAFYLSCRELSRLGPCSFAELVFRDWP 267
V+L G AG+GK+TLA+++ W L +F++ FY SCREL++ S AEL+ +D
Sbjct: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
Query: 268 ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVML 327
I IL++ ++LF++DG DE G ++C W + +P LLGSLL + +L
Sbjct: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
Query: 328 PKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRS 387
P+A+ L+T R AL++L E+ ++ V GF E R+ YF R+F DE QA+RAF L++S
Sbjct: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
Query: 388 NAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGAL 447
N L+ L P V W+ CT L QM++ E T T T L L +L Q L L
Sbjct: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL-QAQPLGPQL 568
Query: 448 RTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQ 507
R L LAA+G+W + ++ +DL + G+ + + FL IL++ + YSFIHL FQ
Sbjct: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLS-YSFIHLCFQ 627
Query: 508 QFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS--GVERLRNPDLIQAGYYSFGLANEKR 565
+F A+ Y L E+E+ R H+ I D++K L G+ L + + GL +++
Sbjct: 628 EFFAAMSYVL--EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTR---FLLGLLSDEG 682
Query: 566 AKELEATFGCRMSP--DIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMA 623
+E+E F CR+S ++ Q + + + HS E L CLYE++ + + +VMA
Sbjct: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQ-PHSL-----ESLHCLYETRNKTFLTQVMA 736
Query: 624 QFKEISLHLNA-VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQ 682
F+E+ + + ++++ +FC+K R+++K+ L E T S + + R
Sbjct: 737 HFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL---IEGRQHRSTWSPTMVVLFRWVPVT 793
Query: 683 HMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PA 741
+W L S+ ++L L ++ + LS S V+ LC+ + C L+ + A
Sbjct: 794 D--AYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 742 DAHRNLCLALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQW 800
+ ++L LR ++T+T L L N D LC+ LR P C L+ L LVSC T+
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 801 ADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDL 860
DL+ L + SL ++L N L D G +LL LRHP C L RL L+ L++ ++L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 861 AAV 863
A+
Sbjct: 972 RAL 974
Score = 128 bits (322), Expect = 2e-29
Identities = 80/198 (40%), Positives = 108/198 (54%), Gaps = 2/198 (1%)
Query: 733 VVFKNISPADAHRNLCLA-LRGHKTVTYLTLQGND-QDDMFPALCEVLRHPECNLRYLGL 790
V+F+ + DA+ + + L+ + + L L GN +LC+ LR P C L L L
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 791 VSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENC 850
C T + DL+ L NQ+LT ++LS N L D GAK L LR P C LQRL L +C
Sbjct: 845 AGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Query: 851 HLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDIT 910
LT C+DLA+VL S L L L +N + + GV+ LCEGLR+P CKL L L ++
Sbjct: 905 GLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
Query: 911 SDGCCDLTKLLQEKSSLL 928
+ +L L QEK LL
Sbjct: 965 DEMRQELRALEQEKPQLL 982
Score = 126 bits (316), Expect = 1e-28
Identities = 76/192 (39%), Positives = 109/192 (56%)
Query: 852 LTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITS 911
+T+A + L +VL V+R L L L+ N + ++ VK LC+ LR P C L+TL L C +T+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 912 DGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSC 971
+ C DL L+ +L LDL N + G K LC+ LR+P C L+ L L C + C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 972 EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLL 1031
+DL S LS + SL LDL QN L GV++L E L + L L L +DE+ + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 1032 EEIEEKNPQLII 1043
+E++ PQL+I
Sbjct: 972 RALEQEKPQLLI 983
Score = 125 bits (313), Expect = 3e-28
Identities = 70/161 (43%), Positives = 91/161 (56%)
Query: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855
T W L L+V ++L ++LS N L K L TLR P+C L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915
+CKDLA L ++ LT L L+ N + + G K LC+ LR P CKLQ L L +C +TSD C
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNL 956
DL +L SL LDL N++ G++ LCE LR P C L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 310 bits (793), Expect = 6e-84
Identities = 217/645 (33%), Positives = 341/645 (52%), Gaps = 26/645 (4%)
Query: 209 VVLYGPAGLGKTTLAQKLMLDWAEDNLI-HKFKYAFYLSCRELSRLGPCSFAELVFRDWP 267
V+L G AG+GK+TLA+++ W L +F++ FY SCREL++ S AEL+ +D
Sbjct: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
Query: 268 ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVML 327
I IL++ ++LF++DG DE G ++C W + +P LLGSLL + +L
Sbjct: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
Query: 328 PKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRS 387
P+A+ L+T R AL++L E+ ++ V GF E R+ YF R+F DE QA+RAF L++S
Sbjct: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
Query: 388 NAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGAL 447
N L+ L P V W+ CT L QM++ E T T T L L +L Q L L
Sbjct: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL-QAQPLGPQL 568
Query: 448 RTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQ 507
R L LAA+G+W + ++ +DL + G+ + + FL IL++ + YSFIHL FQ
Sbjct: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLS-YSFIHLCFQ 627
Query: 508 QFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS--GVERLRNPDLIQAGYYSFGLANEKR 565
+F A+ Y L E+E+ R H+ I D++K L G+ L + + GL +++
Sbjct: 628 EFFAAMSYVL--EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTR---FLLGLLSDEG 682
Query: 566 AKELEATFGCRMSP--DIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMA 623
+E+E F CR+S ++ Q + + + HS E L CLYE++ + + +VMA
Sbjct: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQ-PHSL-----ESLHCLYETRNKTFLTQVMA 736
Query: 624 QFKEISLHLNA-VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQ 682
F+E+ + + ++++ +FC+K R+++K+ L E T S + + R
Sbjct: 737 HFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL---IEGRQHRSTWSPTMVVLFRWVPVT 793
Query: 683 HMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PA 741
+W L S+ ++L L ++ + LS S V+ LC+ + C L+ + A
Sbjct: 794 D--AYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 742 DAHRNLCLALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQW 800
+ ++L LR ++T+T L L N D LC+ LR P C L+ L LVSC T+
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 801 ADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRL 845
DL+ L + SL ++L N L D G +LL LRHP C L RL
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 125 bits (313), Expect = 3e-28
Identities = 70/161 (43%), Positives = 91/161 (56%)
Query: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855
T W L L+V ++L ++LS N L K L TLR P+C L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915
+CKDLA L ++ LT L L+ N + + G K LC+ LR P CKLQ L L +C +TSD C
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNL 956
DL +L SL LDL N++ G++ LCE LR P C L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 122 bits (306), Expect = 2e-27
Identities = 82/219 (37%), Positives = 114/219 (52%), Gaps = 7/219 (3%)
Query: 733 VVFKNISPADAHRNLCLA-LRGHKTVTYLTLQGND-QDDMFPALCEVLRHPECNLRYLGL 790
V+F+ + DA+ + + L+ + + L L GN +LC+ LR P C L L L
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 791 VSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENC 850
C T + DL+ L NQ+LT ++LS N L D GAK L LR P C LQRL L +C
Sbjct: 845 AGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Query: 851 HLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDIT 910
LT C+DLA+VL S L L L +N + + GV+ LCEGLR+P CKL L +
Sbjct: 905 GLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTP 964
Query: 911 SDGCCDLTKLLQEKSSLLCLDLG----LNHIGVKGMKFL 945
++G D ++ SSL LG +H+ +K L
Sbjct: 965 TEG-LDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLL 1002
Score = 111 bits (277), Expect = 4e-24
Identities = 65/155 (41%), Positives = 90/155 (58%)
Query: 852 LTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITS 911
+T+A + L +VL V+R L L L+ N + ++ VK LC+ LR P C L+TL L C +T+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 912 DGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSC 971
+ C DL L+ +L LDL N + G K LC+ LR+P C L+ L L C + C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 972 EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETL 1006
+DL S LS + SL LDL QN L GV++L E L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGL 946
Score = 63.5 bits (153), Expect = 1e-09
Identities = 42/125 (33%), Positives = 60/125 (48%)
Query: 917 LTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCS 976
L +L+ +L LDL N + +K LC+ LR+P C L L L GC + C+DL
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 977 ALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEE 1036
L NQ+L LDL N L +G K L + L S L+ L+L + + L +
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 1037 KNPQL 1041
+P L
Sbjct: 920 ASPSL 924
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 310 bits (793), Expect = 6e-84
Identities = 217/645 (33%), Positives = 341/645 (52%), Gaps = 26/645 (4%)
Query: 209 VVLYGPAGLGKTTLAQKLMLDWAEDNLI-HKFKYAFYLSCRELSRLGPCSFAELVFRDWP 267
V+L G AG+GK+TLA+++ W L +F++ FY SCREL++ S AEL+ +D
Sbjct: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
Query: 268 ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVML 327
I IL++ ++LF++DG DE G ++C W + +P LLGSLL + +L
Sbjct: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
Query: 328 PKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRS 387
P+A+ L+T R AL++L E+ ++ V GF E R+ YF R+F DE QA+RAF L++S
Sbjct: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
Query: 388 NAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGAL 447
N L+ L P V W+ CT L QM++ E T T T L L +L Q L L
Sbjct: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL-QAQPLGPQL 568
Query: 448 RTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQ 507
R L LAA+G+W + ++ +DL + G+ + + FL IL++ + YSFIHL FQ
Sbjct: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLS-YSFIHLCFQ 627
Query: 508 QFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS--GVERLRNPDLIQAGYYSFGLANEKR 565
+F A+ Y L E+E+ R H+ I D++K L G+ L + + GL +++
Sbjct: 628 EFFAAMSYVL--EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTR---FLLGLLSDEG 682
Query: 566 AKELEATFGCRMSP--DIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMA 623
+E+E F CR+S ++ Q + + + HS E L CLYE++ + + +VMA
Sbjct: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQ-PHSL-----ESLHCLYETRNKTFLTQVMA 736
Query: 624 QFKEISLHLNA-VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQ 682
F+E+ + + ++++ +FC+K R+++K+ L E T S + + R
Sbjct: 737 HFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL---IEGRQHRSTWSPTMVVLFRWVPVT 793
Query: 683 HMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PA 741
+W L S+ ++L L ++ + LS S V+ LC+ + C L+ + A
Sbjct: 794 D--AYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 742 DAHRNLCLALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQW 800
+ ++L LR ++T+T L L N D LC+ LR P C L+ L LVSC T+
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 801 ADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRL 845
DL+ L + SL ++L N L D G +LL LRHP C L RL
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 125 bits (313), Expect = 3e-28
Identities = 70/161 (43%), Positives = 91/161 (56%)
Query: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855
T W L L+V ++L ++LS N L K L TLR P+C L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915
+CKDLA L ++ LT L L+ N + + G K LC+ LR P CKLQ L L +C +TSD C
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNL 956
DL +L SL LDL N++ G++ LCE LR P C L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 122 bits (306), Expect = 2e-27
Identities = 82/219 (37%), Positives = 114/219 (52%), Gaps = 7/219 (3%)
Query: 733 VVFKNISPADAHRNLCLA-LRGHKTVTYLTLQGND-QDDMFPALCEVLRHPECNLRYLGL 790
V+F+ + DA+ + + L+ + + L L GN +LC+ LR P C L L L
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 791 VSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENC 850
C T + DL+ L NQ+LT ++LS N L D GAK L LR P C LQRL L +C
Sbjct: 845 AGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Query: 851 HLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDIT 910
LT C+DLA+VL S L L L +N + + GV+ LCEGLR+P CKL L +
Sbjct: 905 GLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTP 964
Query: 911 SDGCCDLTKLLQEKSSLLCLDLG----LNHIGVKGMKFL 945
++G D ++ SSL LG +H+ +K L
Sbjct: 965 TEG-LDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLL 1002
Score = 111 bits (277), Expect = 4e-24
Identities = 65/155 (41%), Positives = 90/155 (58%)
Query: 852 LTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITS 911
+T+A + L +VL V+R L L L+ N + ++ VK LC+ LR P C L+TL L C +T+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 912 DGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSC 971
+ C DL L+ +L LDL N + G K LC+ LR+P C L+ L L C + C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 972 EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETL 1006
+DL S LS + SL LDL QN L GV++L E L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGL 946
Score = 63.5 bits (153), Expect = 1e-09
Identities = 42/125 (33%), Positives = 60/125 (48%)
Query: 917 LTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCS 976
L +L+ +L LDL N + +K LC+ LR+P C L L L GC + C+DL
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 977 ALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEE 1036
L NQ+L LDL N L +G K L + L S L+ L+L + + L +
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 1037 KNPQL 1041
+P L
Sbjct: 920 ASPSL 924
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 261 bits (667), Expect = 2e-69
Identities = 229/713 (32%), Positives = 336/713 (47%), Gaps = 68/713 (9%)
Query: 208 TVVLYGPAGLGKTTLAQKLMLDWAEDNLIH-KFKYAFYLSCREL-SRLGPCSFAELVFRD 265
TVVL GPAG+GKT A+K++ DWA L + +AF++ C EL R G S A+L+
Sbjct: 197 TVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQ 256
Query: 266 WPELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRV 325
P+ +P +LAQ +++LF++DG DEL A G +E VL G LL++
Sbjct: 257 CPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVL-GGLLSKA 315
Query: 326 MLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELM 385
+LP A LLVTTR A L+ P V GF ++D++ YF + F DE +A RA+ +
Sbjct: 316 LLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFV 375
Query: 386 RSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCS-----RFPQG 440
+ N LF L P VCWIVCT L+ Q+E G D T T T ++L F+ S G
Sbjct: 376 KENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADG 435
Query: 441 AQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLR-LFLDGDILRQDRVSKGCY 499
+L+G LR L LA +G+ + + ++LE+L ++ S ++ LFL L ++ Y
Sbjct: 436 PRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTY 495
Query: 500 SFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFG 559
FI SFQ+FL AL Y L ED G V LL G + + L+ + FG
Sbjct: 496 QFIDQSFQEFLAALSYLL-----EDGGVPRTAAGGVGTLLRG-DAQPHSHLVLTTRFLFG 549
Query: 560 LANEKRAKELEATFGCRMSPDIKQELLRC----DISCKGGHSTVTD-------------- 601
L + +R +++E FGC +S +KQE LR C G VT+
Sbjct: 550 LLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEE 609
Query: 602 --------LQELLGCLYESQEEELVKEVMAQFKEISL---HLNAVDVVPSSFCVKHCRNL 650
ELL CLYE+QE+ V++ + +F E++L +DV S+CV+ C
Sbjct: 610 EEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAG 669
Query: 651 QKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSF 710
Q +L++I L V A E + L + G G
Sbjct: 670 Q--ALRLISCRL---VAAQEKKKK-----------SLGKRLQASLGGGSSSQG---TTKQ 710
Query: 711 LSASLVRILCEQIASDTCHLQRVVFKNISPADA-HRNLCLALRGHKTVTYLTLQGNDQDD 769
L ASL+ L + + CHL + + DA R+L ALR +T L L N +
Sbjct: 711 LPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSE 770
Query: 770 M-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGA 828
L E L P+C ++ + V + L L + +LT ++LS +L
Sbjct: 771 AGLRMLSEGLAWPQCRVQTV-RVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMV 829
Query: 829 KLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSREL--THLCLAKNP 879
L L+H C LQ LSL + L+E + ++L AV +L TH L +P
Sbjct: 830 TYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHP 882
Score = 74.3 bits (181), Expect = 6e-13
Identities = 58/202 (28%), Positives = 92/202 (45%), Gaps = 5/202 (2%)
Query: 788 LGLVSCS-ATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLL---YTTLRHPKCFLQ 843
L L+SC Q+ SL + SL + S A LL + + P C L
Sbjct: 672 LRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLS 731
Query: 844 RLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLV 903
L+L +C L +A C+DL+ L + LT L L N + G++ L EGL +P+C++QT+
Sbjct: 732 SLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVR 791
Query: 904 LWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWG 963
+ D G L +L++ +L LDL + + +LC L+ C L+ L L
Sbjct: 792 VQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLAS 850
Query: 964 CSIPPFSCEDLCSALSCNQSLV 985
+ S ++L + LV
Sbjct: 851 VELSEQSLQELQAVKRAKPDLV 872
Score = 51.2 bits (121), Expect = 5e-06
Identities = 28/78 (35%), Positives = 42/78 (53%)
Query: 945 LCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFE 1004
L +A+ PLC+L L L C +P C DL AL +L L L N L +G++ML E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 1005 TLTCSSGTLRTLRLKIDD 1022
L ++T+R+++ D
Sbjct: 779 GLAWPQCRVQTVRVQLPD 796
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 202 bits (515), Expect = 1e-51
Identities = 148/465 (31%), Positives = 234/465 (50%), Gaps = 36/465 (7%)
Query: 209 VVLYGPAGLGKTTLAQKLMLDWAEDNLIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWP 267
VVL G AG GKTTLA+K++LDWA L +F Y FY+SC+E+ L +L+F
Sbjct: 169 VVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCG 228
Query: 268 ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVML 327
+ Q + IL Q ++LF++DGFDEL ++ P LL L+ R L
Sbjct: 229 DNQAPVTEILRQPERLLFILDGFDELQRPFEEKLKK-----RGLSPKESLLHLLIRRHTL 283
Query: 328 PKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRS 387
P +LL+TTRP ALR+L L ++ ++ + GF EE+R YF +F DE QA RAF++++
Sbjct: 284 PTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQK 343
Query: 388 NAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP-------QG 440
N L++ P +CW+VC+ L+ QME+G+ + T T +F+ ++ + P
Sbjct: 344 NDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSE 403
Query: 441 AQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYS 500
LR+L LAA+G+ Q + +L + + L FL + + K YS
Sbjct: 404 LSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYS 463
Query: 501 FIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFGL 560
F H+SFQ F A+ Y + +E++ R G +VQ+LL E+ N ++ + +
Sbjct: 464 FRHISFQDFFHAMSYLV--KEDQSRLGKE-SRREVQRLLEVKEQEGNDEMTLTMQFLLDI 520
Query: 561 ANEKRAKELEATFGCRMSPDIKQELLRCDISCKG-GHSTVTDLQELLGCLYESQEEELVK 619
+ + LE F R+SP + Q+L + H+ DL+ LYE++ + LVK
Sbjct: 521 SKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDLE---FSLYEAKIKNLVK 577
Query: 620 EVMAQFKEISLHLNAVDVVPSSFCVKHC--RNLQKMSLQVIKENL 662
+ +N V SF +KH + Q +L +K +L
Sbjct: 578 ---------GIQMNNV-----SFKIKHSNEKKSQSQNLFSVKSSL 608
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 179 bits (453), Expect = 2e-44
Identities = 119/331 (35%), Positives = 167/331 (50%), Gaps = 16/331 (4%)
Query: 700 DLMGLAINDSFLS----ASLVRIL--CEQIASDTCHLQRVVFKNISPADAHRNLCLALRG 753
D+ L I LS A L+ +L C+ + D C L K+IS A LR
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSA---------LRV 54
Query: 754 HKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQS 812
+ + L L+ N+ D+ + + L+ P C ++ L L +C T LS L +
Sbjct: 55 NPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 813 LTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTH 872
L ++LSDN L D G +LL L P+C L++L LE C L+ A+C+ LA+VL +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 873 LCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDL 932
L ++ N I GV+ LC+GL+ C+L+ L L +C +TSD C DL ++ K+SL L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 933 GLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN 992
G N +G GM LC L P LR LW+W C I C DLC L +SL L L N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 993 PLGSSGVKMLFETLTCSSGTLRTLRLKIDDF 1023
LG G ++L ETL L +L +K F
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Score = 171 bits (434), Expect = 3e-42
Identities = 108/338 (31%), Positives = 163/338 (48%), Gaps = 2/338 (0%)
Query: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRN-LC 748
D+ S N L L + + L V + + + + +C +Q++ +N A L
Sbjct: 47 DISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLS 106
Query: 749 LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807
LR T+ L L N D LCE L P+C L L L CS + L+ L
Sbjct: 107 STLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVL 166
Query: 808 EVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVS 867
+ +S+N++ + G ++L L+ C L+ L LE+C +T NC+DL ++
Sbjct: 167 RAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK 226
Query: 868 RELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSL 927
L L L N +G+ G+ LC GL +P +L+TL +W C IT+ GC DL ++L+ K SL
Sbjct: 227 ASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESL 286
Query: 928 LCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTL 987
L L N +G +G + LCE L +P C L LW+ CS C S L+ N+ L+ L
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 988 DLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFND 1025
+ N L +GV+ L + L LR L L D +D
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Score = 161 bits (408), Expect = 3e-39
Identities = 108/343 (31%), Positives = 164/343 (47%), Gaps = 2/343 (0%)
Query: 701 LMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLCLALRGHKTVTY 759
L L ++D+ L + +++LCE + C L+++ + S + A L LR
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 760 LTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNL 818
LT+ ND ++ LC+ L+ C L L L SC T+ DL + SL + L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 819 SDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKN 878
N+L D G L L HP L+ L + C +T C DL VL L L LA N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 879 PIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIG 938
+G+ G + LCE L P C+L++L + +C T+ C + +L + LL L + N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLE 354
Query: 939 VKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSG 998
G++ LC+ L +P LR LWL C + SC L + L N SL LDL N LG +G
Sbjct: 355 DAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 999 VKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQL 1041
+ L E++ L L L +++E+ L+ +E+ P L
Sbjct: 415 ILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 179 bits (453), Expect = 2e-44
Identities = 119/331 (35%), Positives = 167/331 (50%), Gaps = 16/331 (4%)
Query: 700 DLMGLAINDSFLS----ASLVRIL--CEQIASDTCHLQRVVFKNISPADAHRNLCLALRG 753
D+ L I LS A L+ +L C+ + D C L K+IS A LR
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSA---------LRV 54
Query: 754 HKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQS 812
+ + L L+ N+ D+ + + L+ P C ++ L L +C T LS L +
Sbjct: 55 NPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 813 LTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTH 872
L ++LSDN L D G +LL L P+C L++L LE C L+ A+C+ LA+VL +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 873 LCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDL 932
L ++ N I GV+ LC+GL+ C+L+ L L +C +TSD C DL ++ K+SL L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 933 GLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN 992
G N +G GM LC L P LR LW+W C I C DLC L +SL L L N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 993 PLGSSGVKMLFETLTCSSGTLRTLRLKIDDF 1023
LG G ++L ETL L +L +K F
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Score = 171 bits (434), Expect = 3e-42
Identities = 108/338 (31%), Positives = 163/338 (48%), Gaps = 2/338 (0%)
Query: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRN-LC 748
D+ S N L L + + L V + + + + +C +Q++ +N A L
Sbjct: 47 DISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLS 106
Query: 749 LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807
LR T+ L L N D LCE L P+C L L L CS + L+ L
Sbjct: 107 STLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVL 166
Query: 808 EVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVS 867
+ +S+N++ + G ++L L+ C L+ L LE+C +T NC+DL ++
Sbjct: 167 RAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK 226
Query: 868 RELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSL 927
L L L N +G+ G+ LC GL +P +L+TL +W C IT+ GC DL ++L+ K SL
Sbjct: 227 ASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESL 286
Query: 928 LCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTL 987
L L N +G +G + LCE L +P C L LW+ CS C S L+ N+ L+ L
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 988 DLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFND 1025
+ N L +GV+ L + L LR L L D +D
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Score = 161 bits (408), Expect = 3e-39
Identities = 108/343 (31%), Positives = 164/343 (47%), Gaps = 2/343 (0%)
Query: 701 LMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLCLALRGHKTVTY 759
L L ++D+ L + +++LCE + C L+++ + S + A L LR
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 760 LTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNL 818
LT+ ND ++ LC+ L+ C L L L SC T+ DL + SL + L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 819 SDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKN 878
N+L D G L L HP L+ L + C +T C DL VL L L LA N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 879 PIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIG 938
+G+ G + LCE L P C+L++L + +C T+ C + +L + LL L + N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLE 354
Query: 939 VKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSG 998
G++ LC+ L +P LR LWL C + SC L + L N SL LDL N LG +G
Sbjct: 355 DAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 999 VKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQL 1041
+ L E++ L L L +++E+ L+ +E+ P L
Sbjct: 415 ILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 179 bits (453), Expect = 2e-44
Identities = 119/331 (35%), Positives = 167/331 (50%), Gaps = 16/331 (4%)
Query: 700 DLMGLAINDSFLS----ASLVRIL--CEQIASDTCHLQRVVFKNISPADAHRNLCLALRG 753
D+ L I LS A L+ +L C+ + D C L K+IS A LR
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSA---------LRV 54
Query: 754 HKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQS 812
+ + L L+ N+ D+ + + L+ P C ++ L L +C T LS L +
Sbjct: 55 NPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 813 LTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTH 872
L ++LSDN L D G +LL L P+C L++L LE C L+ A+C+ LA+VL +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 873 LCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDL 932
L ++ N I GV+ LC+GL+ C+L+ L L +C +TSD C DL ++ K+SL L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 933 GLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN 992
G N +G GM LC L P LR LW+W C I C DLC L +SL L L N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 993 PLGSSGVKMLFETLTCSSGTLRTLRLKIDDF 1023
LG G ++L ETL L +L +K F
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Score = 171 bits (434), Expect = 3e-42
Identities = 108/338 (31%), Positives = 163/338 (48%), Gaps = 2/338 (0%)
Query: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRN-LC 748
D+ S N L L + + L V + + + + +C +Q++ +N A L
Sbjct: 47 DISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLS 106
Query: 749 LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807
LR T+ L L N D LCE L P+C L L L CS + L+ L
Sbjct: 107 STLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVL 166
Query: 808 EVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVS 867
+ +S+N++ + G ++L L+ C L+ L LE+C +T NC+DL ++
Sbjct: 167 RAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK 226
Query: 868 RELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSL 927
L L L N +G+ G+ LC GL +P +L+TL +W C IT+ GC DL ++L+ K SL
Sbjct: 227 ASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESL 286
Query: 928 LCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTL 987
L L N +G +G + LCE L +P C L LW+ CS C S L+ N+ L+ L
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 988 DLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFND 1025
+ N L +GV+ L + L LR L L D +D
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Score = 161 bits (408), Expect = 3e-39
Identities = 108/343 (31%), Positives = 164/343 (47%), Gaps = 2/343 (0%)
Query: 701 LMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLCLALRGHKTVTY 759
L L ++D+ L + +++LCE + C L+++ + S + A L LR
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 760 LTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNL 818
LT+ ND ++ LC+ L+ C L L L SC T+ DL + SL + L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 819 SDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKN 878
N+L D G L L HP L+ L + C +T C DL VL L L LA N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 879 PIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIG 938
+G+ G + LCE L P C+L++L + +C T+ C + +L + LL L + N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLE 354
Query: 939 VKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSG 998
G++ LC+ L +P LR LWL C + SC L + L N SL LDL N LG +G
Sbjct: 355 DAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 999 VKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQL 1041
+ L E++ L L L +++E+ L+ +E+ P L
Sbjct: 415 ILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 179 bits (453), Expect = 2e-44
Identities = 119/331 (35%), Positives = 167/331 (50%), Gaps = 16/331 (4%)
Query: 700 DLMGLAINDSFLS----ASLVRIL--CEQIASDTCHLQRVVFKNISPADAHRNLCLALRG 753
D+ L I LS A L+ +L C+ + D C L K+IS A LR
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSA---------LRV 54
Query: 754 HKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQS 812
+ + L L+ N+ D+ + + L+ P C ++ L L +C T LS L +
Sbjct: 55 NPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 813 LTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTH 872
L ++LSDN L D G +LL L P+C L++L LE C L+ A+C+ LA+VL +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 873 LCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDL 932
L ++ N I GV+ LC+GL+ C+L+ L L +C +TSD C DL ++ K+SL L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 933 GLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN 992
G N +G GM LC L P LR LW+W C I C DLC L +SL L L N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 993 PLGSSGVKMLFETLTCSSGTLRTLRLKIDDF 1023
LG G ++L ETL L +L +K F
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Score = 171 bits (434), Expect = 3e-42
Identities = 108/338 (31%), Positives = 163/338 (48%), Gaps = 2/338 (0%)
Query: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRN-LC 748
D+ S N L L + + L V + + + + +C +Q++ +N A L
Sbjct: 47 DISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLS 106
Query: 749 LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807
LR T+ L L N D LCE L P+C L L L CS + L+ L
Sbjct: 107 STLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVL 166
Query: 808 EVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVS 867
+ +S+N++ + G ++L L+ C L+ L LE+C +T NC+DL ++
Sbjct: 167 RAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK 226
Query: 868 RELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSL 927
L L L N +G+ G+ LC GL +P +L+TL +W C IT+ GC DL ++L+ K SL
Sbjct: 227 ASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESL 286
Query: 928 LCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTL 987
L L N +G +G + LCE L +P C L LW+ CS C S L+ N+ L+ L
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 988 DLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFND 1025
+ N L +GV+ L + L LR L L D +D
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Score = 161 bits (408), Expect = 3e-39
Identities = 108/343 (31%), Positives = 164/343 (47%), Gaps = 2/343 (0%)
Query: 701 LMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLCLALRGHKTVTY 759
L L ++D+ L + +++LCE + C L+++ + S + A L LR
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 760 LTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNL 818
LT+ ND ++ LC+ L+ C L L L SC T+ DL + SL + L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 819 SDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKN 878
N+L D G L L HP L+ L + C +T C DL VL L L LA N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 879 PIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIG 938
+G+ G + LCE L P C+L++L + +C T+ C + +L + LL L + N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLE 354
Query: 939 VKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSG 998
G++ LC+ L +P LR LWL C + SC L + L N SL LDL N LG +G
Sbjct: 355 DAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 999 VKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQL 1041
+ L E++ L L L +++E+ L+ +E+ P L
Sbjct: 415 ILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 179 bits (453), Expect = 2e-44
Identities = 119/331 (35%), Positives = 167/331 (50%), Gaps = 16/331 (4%)
Query: 700 DLMGLAINDSFLS----ASLVRIL--CEQIASDTCHLQRVVFKNISPADAHRNLCLALRG 753
D+ L I LS A L+ +L C+ + D C L K+IS A LR
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSA---------LRV 54
Query: 754 HKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQS 812
+ + L L+ N+ D+ + + L+ P C ++ L L +C T LS L +
Sbjct: 55 NPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 813 LTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTH 872
L ++LSDN L D G +LL L P+C L++L LE C L+ A+C+ LA+VL +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 873 LCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDL 932
L ++ N I GV+ LC+GL+ C+L+ L L +C +TSD C DL ++ K+SL L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 933 GLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN 992
G N +G GM LC L P LR LW+W C I C DLC L +SL L L N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 993 PLGSSGVKMLFETLTCSSGTLRTLRLKIDDF 1023
LG G ++L ETL L +L +K F
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Score = 171 bits (434), Expect = 3e-42
Identities = 108/338 (31%), Positives = 163/338 (48%), Gaps = 2/338 (0%)
Query: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRN-LC 748
D+ S N L L + + L V + + + + +C +Q++ +N A L
Sbjct: 47 DISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLS 106
Query: 749 LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807
LR T+ L L N D LCE L P+C L L L CS + L+ L
Sbjct: 107 STLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVL 166
Query: 808 EVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVS 867
+ +S+N++ + G ++L L+ C L+ L LE+C +T NC+DL ++
Sbjct: 167 RAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK 226
Query: 868 RELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSL 927
L L L N +G+ G+ LC GL +P +L+TL +W C IT+ GC DL ++L+ K SL
Sbjct: 227 ASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESL 286
Query: 928 LCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTL 987
L L N +G +G + LCE L +P C L LW+ CS C S L+ N+ L+ L
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 988 DLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFND 1025
+ N L +GV+ L + L LR L L D +D
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Score = 161 bits (408), Expect = 3e-39
Identities = 108/343 (31%), Positives = 164/343 (47%), Gaps = 2/343 (0%)
Query: 701 LMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLCLALRGHKTVTY 759
L L ++D+ L + +++LCE + C L+++ + S + A L LR
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 760 LTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNL 818
LT+ ND ++ LC+ L+ C L L L SC T+ DL + SL + L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 819 SDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKN 878
N+L D G L L HP L+ L + C +T C DL VL L L LA N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 879 PIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIG 938
+G+ G + LCE L P C+L++L + +C T+ C + +L + LL L + N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLE 354
Query: 939 VKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSG 998
G++ LC+ L +P LR LWL C + SC L + L N SL LDL N LG +G
Sbjct: 355 DAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 999 VKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQL 1041
+ L E++ L L L +++E+ L+ +E+ P L
Sbjct: 415 ILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 179 bits (453), Expect = 2e-44
Identities = 119/331 (35%), Positives = 167/331 (50%), Gaps = 16/331 (4%)
Query: 700 DLMGLAINDSFLS----ASLVRIL--CEQIASDTCHLQRVVFKNISPADAHRNLCLALRG 753
D+ L I LS A L+ +L C+ + D C L K+IS A LR
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSA---------LRV 54
Query: 754 HKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQS 812
+ + L L+ N+ D+ + + L+ P C ++ L L +C T LS L +
Sbjct: 55 NPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 813 LTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTH 872
L ++LSDN L D G +LL L P+C L++L LE C L+ A+C+ LA+VL +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 873 LCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDL 932
L ++ N I GV+ LC+GL+ C+L+ L L +C +TSD C DL ++ K+SL L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 933 GLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN 992
G N +G GM LC L P LR LW+W C I C DLC L +SL L L N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 993 PLGSSGVKMLFETLTCSSGTLRTLRLKIDDF 1023
LG G ++L ETL L +L +K F
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Score = 171 bits (434), Expect = 3e-42
Identities = 108/338 (31%), Positives = 163/338 (48%), Gaps = 2/338 (0%)
Query: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRN-LC 748
D+ S N L L + + L V + + + + +C +Q++ +N A L
Sbjct: 47 DISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLS 106
Query: 749 LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807
LR T+ L L N D LCE L P+C L L L CS + L+ L
Sbjct: 107 STLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVL 166
Query: 808 EVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVS 867
+ +S+N++ + G ++L L+ C L+ L LE+C +T NC+DL ++
Sbjct: 167 RAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK 226
Query: 868 RELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSL 927
L L L N +G+ G+ LC GL +P +L+TL +W C IT+ GC DL ++L+ K SL
Sbjct: 227 ASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESL 286
Query: 928 LCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTL 987
L L N +G +G + LCE L +P C L LW+ CS C S L+ N+ L+ L
Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
Query: 988 DLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFND 1025
+ N L +GV+ L + L LR L L D +D
Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Score = 161 bits (408), Expect = 3e-39
Identities = 108/343 (31%), Positives = 164/343 (47%), Gaps = 2/343 (0%)
Query: 701 LMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLCLALRGHKTVTY 759
L L ++D+ L + +++LCE + C L+++ + S + A L LR
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 760 LTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNL 818
LT+ ND ++ LC+ L+ C L L L SC T+ DL + SL + L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 819 SDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKN 878
N+L D G L L HP L+ L + C +T C DL VL L L LA N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 879 PIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIG 938
+G+ G + LCE L P C+L++L + +C T+ C + +L + LL L + N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLE 354
Query: 939 VKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSG 998
G++ LC+ L +P LR LWL C + SC L + L N SL LDL N LG +G
Sbjct: 355 DAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 999 VKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQL 1041
+ L E++ L L L +++E+ L+ +E+ P L
Sbjct: 415 ILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,091,457
Number of Sequences: 37866
Number of extensions: 1875131
Number of successful extensions: 5893
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 5088
Number of HSP's gapped (non-prelim): 279
length of query: 1062
length of database: 18,247,518
effective HSP length: 113
effective length of query: 949
effective length of database: 13,968,660
effective search space: 13256258340
effective search space used: 13256258340
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.