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Search of human proteins with 8923173
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8923173 hypothetical protein LOC54848 [Homo sapiens]
(219 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8923173 hypothetical protein LOC54848 [Homo sapiens] 434 e-122
gi|39930351 dynamin binding protein [Homo sapiens] 118 3e-27
gi|83715966 hypothetical protein LOC389337 [Homo sapiens] 91 1e-18
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 62 4e-10
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 62 4e-10
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 55 5e-08
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 55 5e-08
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 55 5e-08
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 55 5e-08
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 55 5e-08
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 54 1e-07
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 53 2e-07
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 53 2e-07
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 49 3e-06
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 47 1e-05
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 47 1e-05
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 46 2e-05
gi|71274148 pleckstrin homology domain containing, family G (wit... 45 4e-05
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 45 5e-05
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 45 5e-05
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 44 1e-04
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 44 1e-04
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 44 1e-04
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 44 1e-04
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 43 2e-04
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 43 2e-04
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 43 2e-04
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 43 2e-04
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 42 3e-04
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 41 7e-04
>gi|8923173 hypothetical protein LOC54848 [Homo sapiens]
Length = 219
Score = 434 bits (1117), Expect = e-122
Identities = 219/219 (100%), Positives = 219/219 (100%)
Query: 1 MEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEY 60
MEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEY
Sbjct: 1 MEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEY 60
Query: 61 NQKLQEKMTPQGECSVAETLTPEEEHHMKRMMAKREKIIKELIQTEKDYLNDLELCVREV 120
NQKLQEKMTPQGECSVAETLTPEEEHHMKRMMAKREKIIKELIQTEKDYLNDLELCVREV
Sbjct: 61 NQKLQEKMTPQGECSVAETLTPEEEHHMKRMMAKREKIIKELIQTEKDYLNDLELCVREV 120
Query: 121 VQPLRNKKTDRLDVDSLFSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPL 180
VQPLRNKKTDRLDVDSLFSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPL
Sbjct: 121 VQPLRNKKTDRLDVDSLFSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPL 180
Query: 181 EDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLK 219
EDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLK
Sbjct: 181 EDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLK 219
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 118 bits (296), Expect = 3e-27
Identities = 62/175 (35%), Positives = 105/175 (60%), Gaps = 13/175 (7%)
Query: 50 LRRSQSDRTEYNQKLQEK-----MTPQGECSVAETLTPEEEHHMKRMMAKREKIIKELIQ 104
L+ +S+ N +LQ+ ++ Q VA + + E+ +RM+ KR K+I+EL+Q
Sbjct: 735 LKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQ 794
Query: 105 TEKDYLNDLELCVREVVQPLRNKKTDRLDVDSLFSNIESVHQISAKLLSLLEEATTDVEP 164
TE+DY+ DLE+C+ ++ P++ + +D + LF N++ V ++S +LL+ LE
Sbjct: 795 TERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQLLAALE-------- 846
Query: 165 AMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLK 219
+G VFL + LE YKIYC +HDEA ++LE YEK+E++++HL + LK
Sbjct: 847 ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLK 901
>gi|83715966 hypothetical protein LOC389337 [Homo sapiens]
Length = 675
Score = 90.5 bits (223), Expect = 1e-18
Identities = 42/129 (32%), Positives = 80/129 (62%), Gaps = 2/129 (1%)
Query: 90 RMMAKREKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLDVDSLFSNIESVHQISA 149
R + + ++ELI TE YL+ L+LC ++ L+ LDV LFSNI+ + ++++
Sbjct: 26 RSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQQLPQGDLDV--LFSNIDDIIKVNS 83
Query: 150 KLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKE 209
+ L L+E + E +Q++G +FL+ + LE +YK+YC +D+A ++++Y KE EL+
Sbjct: 84 RFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQR 143
Query: 210 HLSHCIQSL 218
H+ ++++
Sbjct: 144 HIQGIVEAV 152
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 62.0 bits (149), Expect = 4e-10
Identities = 38/140 (27%), Positives = 65/140 (46%), Gaps = 8/140 (5%)
Query: 83 EEEHHMKRMMAKREKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLD-------VD 135
E +++ + R ++ EL +TE+DY+ LE V + + ++D V
Sbjct: 12 ESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVK 71
Query: 136 SLFSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAH 195
LFSNIE + + + L ++EE A Q +G FL K IY YC +H++A
Sbjct: 72 MLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQ 130
Query: 196 SILESYEKEEELKEHLSHCI 215
+L K ++ L +C+
Sbjct: 131 KLLLELNKIRTIRTFLLNCM 150
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 62.0 bits (149), Expect = 4e-10
Identities = 38/140 (27%), Positives = 65/140 (46%), Gaps = 8/140 (5%)
Query: 83 EEEHHMKRMMAKREKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLD-------VD 135
E +++ + R ++ EL +TE+DY+ LE V + + ++D V
Sbjct: 12 ESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVK 71
Query: 136 SLFSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAH 195
LFSNIE + + + L ++EE A Q +G FL K IY YC +H++A
Sbjct: 72 MLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQ 130
Query: 196 SILESYEKEEELKEHLSHCI 215
+L K ++ L +C+
Sbjct: 131 KLLLELNKIRTIRTFLLNCM 150
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 55.1 bits (131), Expect = 5e-08
Identities = 31/115 (26%), Positives = 61/115 (53%), Gaps = 4/115 (3%)
Query: 98 IIKELIQTEKDYLNDLELCVREVVQPLR-NKKTDRLDVDSLFSNIESVHQISAKLLSLLE 156
+++ +++TE +Y +L+ + ++PL+ ++K ++ L N+E + L+ LE
Sbjct: 97 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 156
Query: 157 EATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHL 211
E T + A Q +G FL + ++ +Y YC +H A ++L E EEL E +
Sbjct: 157 EC-TKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLT--EHSEELGEFM 208
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 55.1 bits (131), Expect = 5e-08
Identities = 31/115 (26%), Positives = 61/115 (53%), Gaps = 4/115 (3%)
Query: 98 IIKELIQTEKDYLNDLELCVREVVQPLR-NKKTDRLDVDSLFSNIESVHQISAKLLSLLE 156
+++ +++TE +Y +L+ + ++PL+ ++K ++ L N+E + L+ LE
Sbjct: 225 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 284
Query: 157 EATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHL 211
E T + A Q +G FL + ++ +Y YC +H A ++L E EEL E +
Sbjct: 285 EC-TKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLT--EHSEELGEFM 336
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 55.1 bits (131), Expect = 5e-08
Identities = 31/115 (26%), Positives = 61/115 (53%), Gaps = 4/115 (3%)
Query: 98 IIKELIQTEKDYLNDLELCVREVVQPLR-NKKTDRLDVDSLFSNIESVHQISAKLLSLLE 156
+++ +++TE +Y +L+ + ++PL+ ++K ++ L N+E + L+ LE
Sbjct: 275 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 334
Query: 157 EATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHL 211
E T + A Q +G FL + ++ +Y YC +H A ++L E EEL E +
Sbjct: 335 EC-TKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLT--EHSEELGEFM 386
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 55.1 bits (131), Expect = 5e-08
Identities = 31/115 (26%), Positives = 61/115 (53%), Gaps = 4/115 (3%)
Query: 98 IIKELIQTEKDYLNDLELCVREVVQPLR-NKKTDRLDVDSLFSNIESVHQISAKLLSLLE 156
+++ +++TE +Y +L+ + ++PL+ ++K ++ L N+E + L+ LE
Sbjct: 254 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 313
Query: 157 EATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHL 211
E T + A Q +G FL + ++ +Y YC +H A ++L E EEL E +
Sbjct: 314 EC-TKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLT--EHSEELGEFM 365
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 55.1 bits (131), Expect = 5e-08
Identities = 31/115 (26%), Positives = 61/115 (53%), Gaps = 4/115 (3%)
Query: 98 IIKELIQTEKDYLNDLELCVREVVQPLR-NKKTDRLDVDSLFSNIESVHQISAKLLSLLE 156
+++ +++TE +Y +L+ + ++PL+ ++K ++ L N+E + L+ LE
Sbjct: 97 VLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLE 156
Query: 157 EATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHL 211
E T + A Q +G FL + ++ +Y YC +H A ++L E EEL E +
Sbjct: 157 EC-TKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLT--EHSEELGEFM 208
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 53.5 bits (127), Expect = 1e-07
Identities = 34/134 (25%), Positives = 62/134 (46%), Gaps = 8/134 (5%)
Query: 89 KRMMAKREKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLD-------VDSLFSNI 141
+R + R ++ E++ TE+DY+ L + +R D ++ V LFSNI
Sbjct: 44 ERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNI 103
Query: 142 ESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESY 201
E + ++ L+ LE + +G VFL+ K +Y+ YC +H++A +L
Sbjct: 104 EDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKF-CVYEEYCSNHEKALRLLVEL 162
Query: 202 EKEEELKEHLSHCI 215
K ++ L C+
Sbjct: 163 NKIPTVRAFLLSCM 176
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 53.1 bits (126), Expect = 2e-07
Identities = 44/157 (28%), Positives = 65/157 (41%), Gaps = 15/157 (9%)
Query: 71 QGECSVAETLTPEEEH----------HMKRMMAKREKIIKELIQTEKDYLNDLELCVREV 120
Q E S + TP EE H + R +I+E++ TE+ Y+ L
Sbjct: 207 QEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGY 266
Query: 121 VQPLRNKKTDRLDVDSL---FSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIK 177
++ R K T V L F NIE +++ K L LE+ EP + IG FLQ +
Sbjct: 267 IRQCR-KHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQ 325
Query: 178 GPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLSHC 214
IY YC +H A L + K+ + + C
Sbjct: 326 EGFA-IYSEYCNNHPGACLELANLMKQGKYRHFFEAC 361
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 52.8 bits (125), Expect = 2e-07
Identities = 32/109 (29%), Positives = 64/109 (58%), Gaps = 9/109 (8%)
Query: 93 AKREKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLDVD---SLFSNIESVHQISA 149
++ E++ +E+++TE+ Y+ DL V + + PL + L V+ +LF+NIE +++ S+
Sbjct: 101 SRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSS 160
Query: 150 KLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSIL 198
+LL LE ++ + I E F+Q + DIY +YC ++ + ++L
Sbjct: 161 ELLEDLENSS-----SAGGIAECFVQ-RSEDFDIYTLYCMNYPSSLALL 203
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 48.9 bits (115), Expect = 3e-06
Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 2/110 (1%)
Query: 98 IIKELIQTEKDYLNDLELCVREVVQPLR-NKKTDRLDVDSLFSNIESVHQISAKLLSLLE 156
+++ ++ TEK+Y +L+ + ++PL+ N ++V SL N E V L LE
Sbjct: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALE 304
Query: 157 EATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEE 206
E + E +V G L + + +Y YC +H A ++L + E E
Sbjct: 305 ECSKFPENQHKV-GGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELE 353
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 47.4 bits (111), Expect = 1e-05
Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 95 REKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLDVDSL---FSNIESVHQISAKL 151
R +I E++ TE+DY+ L V+ R K+ D + L F NIE +++
Sbjct: 285 RTNVINEILSTERDYIKHLRDICEGYVRQCR-KRADMFSEEQLRTIFGNIEDIYRCQKAF 343
Query: 152 LSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEA 194
+ LE+ P + +G FL+ + + IY YC +H A
Sbjct: 344 VKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNA 385
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 47.4 bits (111), Expect = 1e-05
Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 5/103 (4%)
Query: 95 REKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLDVDSL---FSNIESVHQISAKL 151
R +I E++ TE+DY+ L V+ R K+ D + L F NIE +++
Sbjct: 285 RTNVINEILSTERDYIKHLRDICEGYVRQCR-KRADMFSEEQLRTIFGNIEDIYRCQKAF 343
Query: 152 LSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEA 194
+ LE+ P + +G FL+ + + IY YC +H A
Sbjct: 344 VKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNA 385
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 46.2 bits (108), Expect = 2e-05
Identities = 47/191 (24%), Positives = 82/191 (42%), Gaps = 24/191 (12%)
Query: 38 VESSVSGDHSGTLRRSQSDRTEYNQKLQEKMTPQGECSVAETLTPEEEHHMKRMMA--KR 95
+ESS DHS +S + + L E M P + + T + M+++ K
Sbjct: 986 LESSDETDHSS---KSTEQVAAFCRSLHE-MNPSDQSPSPQDSTGPQLATMRQLSDADKL 1041
Query: 96 EKIIKELIQTEKDYLNDLELCVREVVQPLRNK---KTDRLDVDSLFSNIESVHQISAKLL 152
K+I EL++TE+ Y+ DL + ++PL+ + D LDV LF N+ + + + L
Sbjct: 1042 RKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDV--LFGNLTEMVEFQVEFL 1099
Query: 153 SLLEEA---TTDVEPAMQV---------IGEVFLQIKGPLEDIYKIYCYHHDEAHSILES 200
LE+ D+E +V +G FL + +Y +C H + +L
Sbjct: 1100 KTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFK-LYSAFCASHTKVPKVLVK 1158
Query: 201 YEKEEELKEHL 211
+ + K L
Sbjct: 1159 AKTDTAFKAFL 1169
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 45.4 bits (106), Expect = 4e-05
Identities = 30/127 (23%), Positives = 65/127 (51%), Gaps = 8/127 (6%)
Query: 96 EKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLDVD---SLFSNIESVHQISAKLL 152
+++++E+++TE+ Y+ DL+ V + + +R++ L + +LF NI+ ++ +++LL
Sbjct: 115 DRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELL 174
Query: 153 SLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLS 212
LE D I E F+ K IY YC ++ + ++L + + L +
Sbjct: 175 QDLENCEND----PVAIAECFVS-KSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFR 229
Query: 213 HCIQSLK 219
++LK
Sbjct: 230 ERQETLK 236
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
[Homo sapiens]
Length = 596
Score = 45.1 bits (105), Expect = 5e-05
Identities = 39/190 (20%), Positives = 89/190 (46%), Gaps = 10/190 (5%)
Query: 31 RRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQEKMTPQGECSV--AETLTPEEEHHM 88
RR T+ ++ GDH RS + +++ + + S +E L + +
Sbjct: 114 RRFGQTIQSFTLRGDH-----RSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESL 168
Query: 89 KRMMAKREKIIKELIQTEKDYLNDLELCVREVVQP-LRNKKTDRLDVDSLFSNIESVHQI 147
+R++ I E+ + E+D + DL+L + P L+ ++ +F +++S +
Sbjct: 169 TTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPL 228
Query: 148 SAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEEL 207
LL+ + EAT + ++ IG + + P + Y+ YC + A ++L+ +++ +
Sbjct: 229 HEDLLTRIGEATKP-DGTVEQIGHILVSWL-PRLNAYRGYCSNQLAAKALLDQKKQDPRV 286
Query: 208 KEHLSHCIQS 217
++ L C++S
Sbjct: 287 QDFLQRCLES 296
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
[Homo sapiens]
Length = 542
Score = 45.1 bits (105), Expect = 5e-05
Identities = 39/190 (20%), Positives = 89/190 (46%), Gaps = 10/190 (5%)
Query: 31 RRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQEKMTPQGECSV--AETLTPEEEHHM 88
RR T+ ++ GDH RS + +++ + + S +E L + +
Sbjct: 60 RRFGQTIQSFTLRGDH-----RSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESL 114
Query: 89 KRMMAKREKIIKELIQTEKDYLNDLELCVREVVQP-LRNKKTDRLDVDSLFSNIESVHQI 147
+R++ I E+ + E+D + DL+L + P L+ ++ +F +++S +
Sbjct: 115 TTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPL 174
Query: 148 SAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEEL 207
LL+ + EAT + ++ IG + + P + Y+ YC + A ++L+ +++ +
Sbjct: 175 HEDLLTRIGEATKP-DGTVEQIGHILVSWL-PRLNAYRGYCSNQLAAKALLDQKKQDPRV 232
Query: 208 KEHLSHCIQS 217
++ L C++S
Sbjct: 233 QDFLQRCLES 242
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
Length = 532
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/125 (23%), Positives = 64/125 (51%), Gaps = 3/125 (2%)
Query: 94 KREKIIKELIQTEKDYLNDLELCVREVVQP-LRNKKTDRLDVDSLFSNIESVHQISAKLL 152
KR++ I EL Q E+D + DL+L + P L+ +++ +F ++S+ + +LL
Sbjct: 128 KRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELL 187
Query: 153 SLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLS 212
S L + + + + +G + + P Y YC + A ++L+ +++ +++ L
Sbjct: 188 SQLRDVRKP-DGSTEHVGPILVGWL-PCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQ 245
Query: 213 HCIQS 217
C++S
Sbjct: 246 RCLES 250
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1
[Homo sapiens]
Length = 558
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/125 (23%), Positives = 64/125 (51%), Gaps = 3/125 (2%)
Query: 94 KREKIIKELIQTEKDYLNDLELCVREVVQP-LRNKKTDRLDVDSLFSNIESVHQISAKLL 152
KR++ I EL Q E+D + DL+L + P L+ +++ +F ++S+ + +LL
Sbjct: 154 KRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELL 213
Query: 153 SLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLS 212
S L + + + + +G + + P Y YC + A ++L+ +++ +++ L
Sbjct: 214 SQLRDVRKP-DGSTEHVGPILVGWL-PCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQ 271
Query: 213 HCIQS 217
C++S
Sbjct: 272 RCLES 276
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/125 (23%), Positives = 64/125 (51%), Gaps = 3/125 (2%)
Query: 94 KREKIIKELIQTEKDYLNDLELCVREVVQP-LRNKKTDRLDVDSLFSNIESVHQISAKLL 152
KR++ I EL Q E+D + DL+L + P L+ +++ +F ++S+ + +LL
Sbjct: 122 KRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELL 181
Query: 153 SLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLS 212
S L + + + + +G + + P Y YC + A ++L+ +++ +++ L
Sbjct: 182 SQLRDVRKP-DGSTEHVGPILVGWL-PCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQ 239
Query: 213 HCIQS 217
C++S
Sbjct: 240 RCLES 244
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 43.5 bits (101), Expect = 1e-04
Identities = 50/220 (22%), Positives = 90/220 (40%), Gaps = 40/220 (18%)
Query: 29 LERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQEKMTPQGECSVAETLTP------ 82
L+ K +T + S D + L+RSQ+D T +EKM + AE +T
Sbjct: 1012 LDNFKKNTANDFSNVPDITTGLKRSQTDGTLDQVSHREKM--EQTFRSAEQITALCRSFN 1069
Query: 83 -----------EEEHHMKRMMAKR-------EKIIKELIQTEKDYLNDLELCVREVVQPL 124
E + R +A+ K+I+EL+ TEK Y+ DL ++PL
Sbjct: 1070 DSQANGMEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPL 1129
Query: 125 RNKK-TDRLDVDSLFSNIESVHQISAKLLSLLE------------EATTDVEPAMQVIGE 171
+N+ + +++SLF ++ + + L LE E + + +G
Sbjct: 1130 QNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGG 1189
Query: 172 VFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHL 211
FL + +Y +C +H + +LE + ++ K L
Sbjct: 1190 SFLYYADHFK-LYSGFCANHIKVQKVLERAKTDKAFKAFL 1228
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 43.1 bits (100), Expect = 2e-04
Identities = 38/144 (26%), Positives = 67/144 (46%), Gaps = 19/144 (13%)
Query: 83 EEEHHMKRMMAKREKIIKELIQTEKDYLNDLELCV-------REVVQPLRNKKTDRLDVD 135
E E + +R +++EL++TE+DY+ DL V +E P K D++
Sbjct: 1958 EMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKI--- 2014
Query: 136 SLFSNIESVHQISAK-LLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEA 194
+F NI ++ L LE+ D E +G +F++ + L +Y YC + ++
Sbjct: 2015 -VFGNIHQIYDWHRDFFLGELEKCLEDPEK----LGSLFVKHERRLH-MYIAYCQNKPKS 2068
Query: 195 HSILESYEKE--EELKEHLSHCIQ 216
I+ Y E+LK+ L H +Q
Sbjct: 2069 EHIVSEYIDTFFEDLKQRLGHRLQ 2092
Score = 36.6 bits (83), Expect = 0.017
Identities = 49/186 (26%), Positives = 78/186 (41%), Gaps = 38/186 (20%)
Query: 55 SDRTEYNQKLQEKMTPQGECSVAETLTPEEEHHM---KRMMAKREK-IIKELIQTEKDYL 110
SD + ++ LQ + P +E + H + KR A+R++ I+ ELIQTEK Y+
Sbjct: 1250 SDSNKSSKSLQLDIIP-ASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYV 1308
Query: 111 NDLELC-----------VREVVQPLRNKKTDRLDVDSLFSNIESVHQ----ISAKLLSLL 155
DL C V E+ + NK+ +F N++ +++ I K L
Sbjct: 1309 RDLRECMDTYLWEMTSGVEEIPPGIVNKEL------IIFGNMQEIYEFHNNIFLKELEKY 1362
Query: 156 EEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHH-DEAHSILE---SYEKEEELKEHL 211
E+ DV + F +Y YC + D ILE SY E + + L
Sbjct: 1363 EQLPEDVGHCFVTWADKF--------QMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGL 1414
Query: 212 SHCIQS 217
++ I S
Sbjct: 1415 ANSISS 1420
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 42.7 bits (99), Expect = 2e-04
Identities = 37/136 (27%), Positives = 67/136 (49%), Gaps = 11/136 (8%)
Query: 82 PEEEHHMKRMMAKREKIIKELIQTEKDYLNDLELCVREVVQPLRNK--KTDRLDVDSL-F 138
PEEE K + R ++ EL+QTEKDY+ DL + V ++ + K D D + F
Sbjct: 1918 PEEEQKAKALRG-RMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVF 1976
Query: 139 SNIESVHQISAK-LLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSI 197
NI ++ L+ LE+ + + + ++F++ + L IY YC + + I
Sbjct: 1977 GNIHQIYDWHKDFFLAELEKCIQEQDR----LAQLFIKHERKLH-IYVWYCQNKPRSEYI 2031
Query: 198 LESYEKE-EELKEHLS 212
+ Y+ EE+K+ ++
Sbjct: 2032 VAEYDAYFEEVKQEIN 2047
Score = 38.9 bits (89), Expect = 0.003
Identities = 46/201 (22%), Positives = 81/201 (40%), Gaps = 40/201 (19%)
Query: 23 RSRLYMLERRKTDTVVE------SSVSGDHSGTLRRSQSDRTEYNQKLQEKMTPQGECSV 76
+ ++ E RK T V+ S G + +L ++ TE N+ L+ + P S
Sbjct: 1201 KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIP-ASLSD 1259
Query: 77 AETLTPEEEHHM----KRMMAKREKIIKELIQTEKDYLNDLELC-----------VREVV 121
E + H + ++ K+E I+ EL+QTEK Y+ DL C V E+
Sbjct: 1260 REVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIP 1319
Query: 122 QPLRNKKTDRLDVDSLFSNIESVH----QISAKLLSLLEEATTDVEPAMQVIGEVFLQIK 177
+ NK+ +F NI+ ++ I K L E+ DV + F
Sbjct: 1320 PGILNKE------HIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKF---- 1369
Query: 178 GPLEDIYKIYCYHHDEAHSIL 198
+Y YC + +++ ++
Sbjct: 1370 ----QMYVTYCKNKPDSNQLI 1386
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 42.7 bits (99), Expect = 2e-04
Identities = 37/136 (27%), Positives = 67/136 (49%), Gaps = 11/136 (8%)
Query: 82 PEEEHHMKRMMAKREKIIKELIQTEKDYLNDLELCVREVVQPLRNK--KTDRLDVDSL-F 138
PEEE K + R ++ EL+QTEKDY+ DL + V ++ + K D D + F
Sbjct: 221 PEEEQKAKALRG-RMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVF 279
Query: 139 SNIESVHQISAK-LLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSI 197
NI ++ L+ LE+ + + + ++F++ + L IY YC + + I
Sbjct: 280 GNIHQIYDWHKDFFLAELEKCIQEQDR----LAQLFIKHERKLH-IYVWYCQNKPRSEYI 334
Query: 198 LESYEKE-EELKEHLS 212
+ Y+ EE+K+ ++
Sbjct: 335 VAEYDAYFEEVKQEIN 350
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 42.7 bits (99), Expect = 2e-04
Identities = 29/122 (23%), Positives = 55/122 (45%), Gaps = 3/122 (2%)
Query: 95 REKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLD--VDSLFSNIESVHQISAKLL 152
R +I E++ TE+ Y+ L+ ++ R ++ D + +F NIE +++ +
Sbjct: 104 RANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFV 163
Query: 153 SLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLS 212
LE+ + +P + IG FL+ + IY YC +H +A L K+ +
Sbjct: 164 RDLEKQYNNDDPHLSEIGPCFLEHQDGFW-IYSEYCNNHLDACMELSKLMKDSRYQHFFE 222
Query: 213 HC 214
C
Sbjct: 223 AC 224
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 42.4 bits (98), Expect = 3e-04
Identities = 30/128 (23%), Positives = 58/128 (45%), Gaps = 14/128 (10%)
Query: 97 KIIKELIQTEKDYLNDLELCVREVVQPLRNKK-TDRLDVDSLFSNIESVHQISAKLLSLL 155
K+I+EL+ TEK Y+ DL ++PL+N+ + +++SLF ++ + + L L
Sbjct: 27 KVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETL 86
Query: 156 E------------EATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEK 203
E E + + +G FL + +Y +C +H + +LE +
Sbjct: 87 EDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGFCANHIKVQKVLERAKT 145
Query: 204 EEELKEHL 211
++ K L
Sbjct: 146 DKAFKAFL 153
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 41.2 bits (95), Expect = 7e-04
Identities = 41/142 (28%), Positives = 65/142 (45%), Gaps = 7/142 (4%)
Query: 76 VAETLTPEEEHHMKRMMAK--REKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLD 133
V E L EE H + R + E+ QTE+ Y LE + + PL+ T +
Sbjct: 172 VYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLT-AAE 230
Query: 134 VDSLFSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDE 193
DS+F NI + ++ L+ + ++ V Q + +VF+ K L IY YC +
Sbjct: 231 FDSVFINIPELVKLHRNLMQEIHDSI--VNKNDQNLYQVFINYKERLV-IYGQYCSGVES 287
Query: 194 AHSILESYEK-EEELKEHLSHC 214
A S L+ K +E++K L C
Sbjct: 288 AISSLDYISKTKEDVKLKLEEC 309
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.349
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,791,974
Number of Sequences: 37866
Number of extensions: 320124
Number of successful extensions: 1477
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 176
Number of HSP's that attempted gapping in prelim test: 1340
Number of HSP's gapped (non-prelim): 293
length of query: 219
length of database: 18,247,518
effective HSP length: 98
effective length of query: 121
effective length of database: 14,536,650
effective search space: 1758934650
effective search space used: 1758934650
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.