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Search of human proteins with 85986601
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|85986601 relaxin/insulin-like family peptide receptor 1
[Homo sapiens]
(757 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 1557 0.0
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo... 796 0.0
gi|31657136 follicle stimulating hormone receptor isoform 2 prec... 175 1e-43
gi|106067657 luteinizing hormone/choriogonadotropin receptor pre... 169 7e-42
gi|31657138 follicle stimulating hormone receptor isoform 1 prec... 157 3e-38
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 150 3e-36
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 147 3e-35
gi|64085121 thyroid stimulating hormone receptor isoform 1 precu... 146 8e-35
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 124 3e-28
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 119 8e-27
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 119 8e-27
gi|198041768 synleurin [Homo sapiens] 119 1e-26
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 116 9e-26
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 115 2e-25
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 115 2e-25
gi|225579152 insulin-like growth factor binding protein, acid la... 114 3e-25
gi|4826772 insulin-like growth factor binding protein, acid labi... 114 3e-25
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 114 3e-25
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 114 4e-25
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 114 4e-25
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 114 4e-25
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 112 2e-24
gi|153251229 chondroadherin precursor [Homo sapiens] 106 9e-23
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 105 1e-22
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 105 1e-22
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 105 1e-22
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 105 2e-22
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 105 2e-22
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 103 6e-22
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 102 1e-21
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 1557 bits (4032), Expect = 0.0
Identities = 757/757 (100%), Positives = 757/757 (100%)
Query: 1 MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADED 60
MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADED
Sbjct: 1 MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADED 60
Query: 61 NCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRA 120
NCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRA
Sbjct: 61 NCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRA 120
Query: 121 VPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLY 180
VPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLY
Sbjct: 121 VPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLY 180
Query: 181 LSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDK 240
LSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDK
Sbjct: 181 LSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDK 240
Query: 241 PLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDEL 300
PLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDEL
Sbjct: 241 PLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDEL 300
Query: 301 DLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ 360
DLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ
Sbjct: 301 DLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ 360
Query: 361 RMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTC 420
RMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTC
Sbjct: 361 RMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTC 420
Query: 421 FGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWM 480
FGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWM
Sbjct: 421 FGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWM 480
Query: 481 ESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGF 540
ESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGF
Sbjct: 481 ESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGF 540
Query: 541 IVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYG 600
IVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYG
Sbjct: 541 IVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYG 600
Query: 601 SMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGT 660
SMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGT
Sbjct: 601 SMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGT 660
Query: 661 ITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWV 720
ITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWV
Sbjct: 661 ITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWV 720
Query: 721 EMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS 757
EMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
Sbjct: 721 EMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS 757
>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
sapiens]
Length = 754
Score = 796 bits (2055), Expect = 0.0
Identities = 394/716 (55%), Positives = 520/716 (72%), Gaps = 11/716 (1%)
Query: 8 FYILIFGKYFSHGGGQDV--KCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDN 65
F +LI K F+ G + C GYFPCGN+TKCLP+ HC+G DDCGN ADE+NCGD
Sbjct: 24 FIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDT 83
Query: 66 NGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVS 125
+GW+ F + + A T EC + P C C+ EL+C +L++VP +S
Sbjct: 84 SGWATIFGTVHGNANSV-------ALTQECFLKQYPQCCDCKETELECVNGDLKSVPMIS 136
Query: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
+NVT +SL+ N I LP F Y L+K++LQ+N I IS AF GL +L LYL+HN
Sbjct: 137 NNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNC 196
Query: 186 ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQH 245
IT L+PG+F+DLH+L WLI++DN ++RIS F GLNSL L ++NN L LP K +C
Sbjct: 197 ITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALP-KQMCAQ 255
Query: 246 MPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
MP+L+W+DLEGN I L N TF+SC +LTVL + +N+I + E TF+ L+ L ELDL SN
Sbjct: 256 MPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSN 315
Query: 306 KIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRP 365
I L P +FKDLK L +LNLS NP+ + NQF+ L +L+SL LE IEI NI RMF+P
Sbjct: 316 TITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQP 375
Query: 366 LMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIF 425
+ NLSHIYFK F+YC YAPHVR C P TDGISS E+LLA+ I R+FVWV++ +TCFGN+F
Sbjct: 376 MKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLF 435
Query: 426 VICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 485
VI MR +I++EN +AMSI LCCADCLMG+YLF +G FD+K+RG+Y K+A LWMES C
Sbjct: 436 VIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQC 495
Query: 486 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFI 545
+L+G LA+LSTEVSVLLLT+LTLEK++ IV+PF +RPGK +T +LI IW+ GF++A I
Sbjct: 496 RLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVI 555
Query: 546 PLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYS 605
P NK++F N+YG NGVCFPL+ + TE IG++ YS+ IFLG+NL AF+IIVFSY +MF S
Sbjct: 556 PFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCS 615
Query: 606 VHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWV 665
+ ++A+ TE+RN +E+ +A RFFFIVF+DA+CWIP+FVVK LSL +VEIP T+TSW+
Sbjct: 616 IQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWI 675
Query: 666 VIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVE 721
VIF LP+NSALNPILYTLTT FK+ + + + + QRKS+ +K+ + S +W+E
Sbjct: 676 VIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKH-QRKSIFKIKKKSLSTSIVWIE 730
>gi|31657136 follicle stimulating hormone receptor isoform 2
precursor [Homo sapiens]
Length = 633
Score = 175 bits (444), Expect = 1e-43
Identities = 148/567 (26%), Positives = 277/567 (48%), Gaps = 38/567 (6%)
Query: 134 QWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRIT-FLKPG 192
Q + + ++P D +N +L+ + K+ I AF G L K+ +S N + ++
Sbjct: 33 QESKVTEIPSDLPRNAIELRFVL---TKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEAD 89
Query: 193 VFEDLHRLEWLIIED-NHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHW 251
VF +L +L + IE N+L I+P F L +L L++ N + LPD + ++
Sbjct: 90 VFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKV-L 148
Query: 252 LDLEGN-HIHNLRNLTFISCSNLTVLV-MRKNKINHLNENTFAPLQKLDELDLG-SNKIE 308
LD++ N +IH + +F+ S +V++ + KN I ++ F Q LDEL+L +N +E
Sbjct: 149 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLE 207
Query: 309 NLPPLIFKDLKE---LSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRP 365
LP +F LS+L+ N + I + DY+ + + + ++ + +
Sbjct: 208 ELPNDVFHGASGPVILSELHPICN--KSILRQEVDYMTQARG---QRSSLAEDNESSYSR 262
Query: 366 LMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIF 425
++++ F + C V +C P D + E+++ I RV +W +S + GNI
Sbjct: 263 GFDMTYTEFD-YDLCNEVVDV-TCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNII 320
Query: 426 VICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 485
V+ + + + + + +L AD +GIYL +I D+ + +Y+ +A W C
Sbjct: 321 VLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGC 380
Query: 486 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCR-TITVLILIWITGFIVAF 544
G + ++E+SV LT +TLE++ I + + + R +V+++ WI F A
Sbjct: 381 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAAL 440
Query: 545 IPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFY 604
P+ F + Y +C P+ D +S +Q+Y +++ L +N+ AF++I Y ++
Sbjct: 441 FPI----FGISSYMKVSICLPM---DIDSPLSQLYVMSL-LVLNVLAFVVICGCYIHIYL 492
Query: 605 SVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSW 664
+V I ++ + +AKR ++FTD LC PI + L+V + T++
Sbjct: 493 TVRNPNIVSS------SSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI-TVSKA 545
Query: 665 VVIFIL--PINSALNPILYTLTTRPFK 689
++ +L PINS NP LY + T+ F+
Sbjct: 546 KILLVLFHPINSCANPFLYAIFTKNFR 572
>gi|106067657 luteinizing hormone/choriogonadotropin receptor
precursor [Homo sapiens]
Length = 699
Score = 169 bits (429), Expect = 7e-42
Identities = 140/603 (23%), Positives = 277/603 (45%), Gaps = 51/603 (8%)
Query: 122 PSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYL-QNNKITSISIYAFRGLNSLTKLY 180
P ++ +T +SL + ++ +P F+ +++ K+ + Q + + I AF L +L+++
Sbjct: 45 PGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEIL 104
Query: 181 LSHNR-ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPT--FYGLNSLILLVLMNNVLTRL 237
+ + + + +++PG F +L RL++L I + + + T F ++ IL + N +T +
Sbjct: 105 IQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTI 164
Query: 238 PDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKN-KINHLNENTFAPLQK 296
P L L GN +++ F + + LT L +++N + ++ F
Sbjct: 165 PGNAFQGMNNESVTLKLYGNGFEEVQSHAF-NGTTLTSLELKENVHLEKMHNGAFRGATG 223
Query: 297 LDELDLGSNKIENLPPLIFKDLKEL---SQLNLSYNPIQKIQANQFDYLVKLKSLSLEGI 353
LD+ S K++ LP + ++ L S +L P ++ N + + S
Sbjct: 224 PKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFR 283
Query: 354 EISNIQQR------------------------MFRPLMNLSHIYFKKFQYCGYAPHVRSC 389
+ +Q ++ ++ S + ++Y P C
Sbjct: 284 NLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRC 343
Query: 390 KPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCC 449
P D + E+++ RV +W+++ + GN+ V+ + R + + + +L
Sbjct: 344 APEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSF 403
Query: 450 ADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLE 509
AD MG+YL +I D + +G+Y HA W + C G + ++E+SV LT +TLE
Sbjct: 404 ADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLE 463
Query: 510 KYICIVYPFRCVRPGKCR-TITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHS 568
++ I Y + + R I +++ W+ ++A +PL NY + +CFP+
Sbjct: 464 RWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVG---VSNYMKVS-ICFPM-- 517
Query: 569 EDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAK 628
D E+ +Q+Y + I + +N+ AF II Y ++++V + AT K+ +AK
Sbjct: 518 -DVETTLSQVYILTILI-LNVVAFFIICACYIKIYFAVRNPELMAT------NKDTKIAK 569
Query: 629 RFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFIL--PINSALNPILYTLTTR 686
+ ++FTD C PI + +V + T+T+ V+ +L PINS NP LY + T+
Sbjct: 570 KMAILIFTDFTCMAPISFFAISAAFKVPLI-TVTNSKVLLVLFYPINSCANPFLYAIFTK 628
Query: 687 PFK 689
F+
Sbjct: 629 TFQ 631
>gi|31657138 follicle stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 695
Score = 157 bits (397), Expect = 3e-38
Identities = 150/627 (23%), Positives = 283/627 (45%), Gaps = 96/627 (15%)
Query: 134 QWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRIT-FLKPG 192
Q + + ++P D +N +L+ + K+ I AF G L K+ +S N + ++
Sbjct: 33 QESKVTEIPSDLPRNAIELRFVL---TKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEAD 89
Query: 193 VFEDLHRLEWLIIED-NHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHW 251
VF +L +L + IE N+L I+P F L +L L++ N + LPD + ++
Sbjct: 90 VFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKV-L 148
Query: 252 LDLEGN-HIHNLRNLTFISCSNLTVLV-MRKNKINHLNENTFAPLQKLDELDLGSN---- 305
LD++ N +IH + +F+ S +V++ + KN I ++ F Q LDEL+L N
Sbjct: 149 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLE 207
Query: 306 ---------------------KIENLPPLIFKDLKELS--------------------QL 324
+I +LP ++LK+L +
Sbjct: 208 ELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEA 267
Query: 325 NLSY-----------------NPI--QKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRP 365
+L+Y +PI + I + DY+ + + + ++ + +
Sbjct: 268 SLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARG---QRSSLAEDNESSYSR 324
Query: 366 LMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIF 425
++++ F + C V +C P D + E+++ I RV +W +S + GNI
Sbjct: 325 GFDMTYTEFD-YDLCNEVVDV-TCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNII 382
Query: 426 VICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHC 485
V+ + + + + + +L AD +GIYL +I D+ + +Y+ +A W C
Sbjct: 383 VLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGC 442
Query: 486 QLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCR-TITVLILIWITGFIVAF 544
G + ++E+SV LT +TLE++ I + + + R +V+++ WI F A
Sbjct: 443 DAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAAL 502
Query: 545 IPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFY 604
P+ F + Y +C P+ D +S +Q+Y +++ L +N+ AF++I Y ++
Sbjct: 503 FPI----FGISSYMKVSICLPM---DIDSPLSQLYVMSL-LVLNVLAFVVICGCYIHIYL 554
Query: 605 SVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSW 664
+V I ++ + +AKR ++FTD LC PI + L+V + T++
Sbjct: 555 TVRNPNIVSS------SSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLI-TVSKA 607
Query: 665 VVIFIL--PINSALNPILYTLTTRPFK 689
++ +L PINS NP LY + T+ F+
Sbjct: 608 KILLVLFHPINSCANPFLYAIFTKNFR 634
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 150 bits (380), Expect = 3e-36
Identities = 160/679 (23%), Positives = 276/679 (40%), Gaps = 113/679 (16%)
Query: 105 LCQGLELDCDETNLRAVP----SVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNN 160
L Q L D+ +L VP S + A++L N I +P F N L L+L NN
Sbjct: 152 LVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNN 211
Query: 161 KITSISIYAFRGLNSLTKLYLSHNR-----------------------ITFLKPGVFEDL 197
KI S+S + F GL++L L L++N I+ + G F+
Sbjct: 212 KIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGN 271
Query: 198 HRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL--------------------TRL 237
L + + DN LS + F+ L+ L LV+ + T++
Sbjct: 272 PLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKI 331
Query: 238 PDKP--LCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQ 295
P LCQ L LDL N+I +L + F C L + +++N+I + E TF L
Sbjct: 332 SSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLI 389
Query: 296 KLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEI 355
L LDL N I + F L ++ L++S+N + + L +LK + ++
Sbjct: 390 SLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKE 449
Query: 356 SNIQQRMFRPLMNLSHIYFKKFQYCGY-----------------------------APHV 386
+ + + F L +LS Y +Q C + A +V
Sbjct: 450 A-LAAKDFVNLRSLSVPY--AYQCCAFWGCDSYANLNTEDNSLQDHSVAQEKGTADAANV 506
Query: 387 RS-------------CKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYI 433
S C P+T E LL S + R+ VW + V F N+ VI
Sbjct: 507 TSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFAS 566
Query: 434 RSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAI 493
+ + I + ++ MGIY ++ D G + + W + C++ G LA+
Sbjct: 567 CTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAV 626
Query: 494 LSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVA-FIPLSNKEF 552
S+E ++ LL T+E+ + + + + V L+ G VA PL F
Sbjct: 627 FSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPL----F 682
Query: 553 FKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAIT 612
+ Y + +C P + +T S+G ++V + L +N AF+++ Y ++ ++ + ++
Sbjct: 683 HRGEYSASPLCLPFPTGETPSLG---FTVTLVL-LNSLAFLLMAVIYTKLYCNLEKEDLS 738
Query: 613 ATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLL-QVEIPGTITSWVVIFILP 671
+ + K +++FT+ + + P+ F L+ + I I V + P
Sbjct: 739 E-------NSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFP 791
Query: 672 INSALNPILYTLTTRPFKE 690
+ + LNP+LY FKE
Sbjct: 792 LPACLNPVLYVFFNPKFKE 810
Score = 120 bits (301), Expect = 5e-27
Identities = 95/308 (30%), Positives = 144/308 (46%), Gaps = 10/308 (3%)
Query: 104 CLCQG-LELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNK 161
C C G +DC L AVP +S+ A+ + N I +LP D FKN+ L++L L N
Sbjct: 33 CSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGND 92
Query: 162 ITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGL 221
++ I A GL L L L +N++ + L L+ L ++ NH++ + +F GL
Sbjct: 93 LSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGL 152
Query: 222 NSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKN 281
L L L +N LT +P PL ++P L L L N I ++ + F + S+L VL + N
Sbjct: 153 VQLRHLWLDDNSLTEVPVHPL-SNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNN 211
Query: 282 KINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDY 341
KI L+++ F L L+ LDL N + P I K L L +L N I I FD
Sbjct: 212 KIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAI-KALPSLKELGFHSNSISVIPDGAFDG 270
Query: 342 LVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFK------KFQYCGYAPHVRSCKPNTDG 395
L+++ L +S + F L +L + + +F H+ S
Sbjct: 271 NPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTK 330
Query: 396 ISSLENLL 403
ISS+ N L
Sbjct: 331 ISSIPNNL 338
Score = 53.1 bits (126), Expect = 9e-07
Identities = 37/138 (26%), Positives = 59/138 (42%)
Query: 281 NKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFD 340
N I L E+ F L+EL L N + + P LKEL L L N ++ + +
Sbjct: 67 NNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIR 126
Query: 341 YLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLE 400
L L+SL L+ I+++ + F L+ L H++ H S P ++
Sbjct: 127 GLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLAL 186
Query: 401 NLLASIIQRVFVWVVSAV 418
N ++SI F + S V
Sbjct: 187 NKISSIPDFAFTNLSSLV 204
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 147 bits (372), Expect = 3e-35
Identities = 162/679 (23%), Positives = 270/679 (39%), Gaps = 128/679 (18%)
Query: 115 ETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLN 174
E ++A S+S+ + AM+L N I +P F N L L+L NN+I S+ F GL+
Sbjct: 176 EIPVQAFRSLSA-LQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLH 234
Query: 175 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL 234
SL L L++N + P L L+ L N++ I F G SLI + +N +
Sbjct: 235 SLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPI 293
Query: 235 -------------------------TRLPD---------------------KPLCQHMPR 248
T PD + +C +P
Sbjct: 294 QFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPN 353
Query: 249 LHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIE 308
L LDL N + +L + F C L + +R N+I + +TF L L L+L NKI
Sbjct: 354 LQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIA 411
Query: 309 NLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMN 368
+ P F L L +L+LS N + L LK ++ S I F L
Sbjct: 412 IIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQ-SLISSENFPELKV 470
Query: 369 LSHIYFKKFQYCGY---------------------------------------------- 382
+ Y +Q C +
Sbjct: 471 IEMPY--AYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLD 528
Query: 383 ------APHVRSCKPNTDGISSLENLLASIIQRVFVWVVS--AVTCFGNIFVICMR-PYI 433
A H C P+ E+LL + R+ VW ++ A+TC + R P
Sbjct: 529 FEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLY 588
Query: 434 RSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAI 493
S KL I + + L G+ V+ G D G + +H W C ++G L+I
Sbjct: 589 ISPIKLL---IGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSI 645
Query: 494 LSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIW-ITGFIVAFIPLSNKEF 552
++E SV LLT LE+ + Y + ++ V+IL+ + +A +PL
Sbjct: 646 FASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLG--- 702
Query: 553 FKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAIT 612
+ YG + +C PL + ++G Y VA+ L +N F+++ +Y ++ ++ +
Sbjct: 703 -GSKYGASPLCLPLPFGEPSTMG---YMVALIL-LNSLCFLMMTIAYTKLYCNLDKG--- 754
Query: 613 ATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVE-IPGTITSWVVIFILP 671
++ N M+ K ++FT+ + P+ + F SL+ + I + ++++ ++P
Sbjct: 755 --DLENIWDCSMV--KHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVP 810
Query: 672 INSALNPILYTLTTRPFKE 690
+ + LNP+LY L FKE
Sbjct: 811 LPACLNPLLYILFNPHFKE 829
Score = 102 bits (253), Expect = 2e-21
Identities = 78/287 (27%), Positives = 122/287 (42%), Gaps = 32/287 (11%)
Query: 96 LVGSVPVQCLCQG-----LELDCDETNLRAVPSVSSNVTA-------------------- 130
L+ P C C+ L +DC + L +PS S T+
Sbjct: 30 LLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSL 89
Query: 131 -----MSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
+ L N + +P F + L+ L LQNN++ + A + L SL L L N
Sbjct: 90 RFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANH 149
Query: 186 ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQH 245
I+++ P F LH L L ++DN L+ I F L++L + L N + +PD +
Sbjct: 150 ISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAF-GN 208
Query: 246 MPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
+ L L L N IH+L F +L L + N ++ L L EL SN
Sbjct: 209 LSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSN 267
Query: 306 KIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEG 352
I ++P F L ++ NPIQ + + F +L +L++L+L G
Sbjct: 268 NIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNG 314
Score = 45.8 bits (107), Expect = 1e-04
Identities = 47/178 (26%), Positives = 73/178 (41%), Gaps = 34/178 (19%)
Query: 251 WLDLEGNHIHNL------------------RNLTFI------SCSNLTVLVMRKNKINHL 286
+LDL N+I L LT+I +L VL+++ N++ H+
Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
Query: 287 NENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLK 346
L+ L L L +N I +PP F L L L L N + +I F L L+
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
Query: 347 SLSLEGIEISNIQQRMFRPLMNL--SHIYFKKFQYCGYAPHVRSCKPNTDGISSLENL 402
+++L +I +I F L +L H++ + G K DG+ SLE L
Sbjct: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLG--------KKCFDGLHSLETL 239
>gi|64085121 thyroid stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 764
Score = 146 bits (368), Expect = 8e-35
Identities = 144/566 (25%), Positives = 253/566 (44%), Gaps = 63/566 (11%)
Query: 141 LPPDCFKNY-HDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR-ITFLKPGVFEDLH 198
+P + F+ ++ L L NN TS+ YAF G L +YL+ N+ +T + F ++
Sbjct: 167 IPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNG-TKLDAVYLNKNKYLTVIDKDAFGGVY 225
Query: 199 RLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNN-VLTRLPDKPLCQHMPRLHWLDLE-G 256
L+ D + ++ GL L L+ N L +LP H+ R DL
Sbjct: 226 SGPSLL--DVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRA---DLSYP 280
Query: 257 NHIHNLRN-------LTFISCSNLTVLVMRKNK-INHLNENTFAPLQKLDELDLGSNKIE 308
+H +N L + C+ ++ +R+ K +N LN +PL + E +LG + +
Sbjct: 281 SHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALN----SPLHQEYEENLGDSIV- 335
Query: 309 NLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMN 368
KE S+ ++N A+ + + + + EI Q + P
Sbjct: 336 --------GYKEKSKFQDTHN-----NAHYYVFFEEQED------EIIGFGQELKNPQEE 376
Query: 369 LSHIYFKKFQY--CGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFV 426
+ + Y CG + + C P +D + E+++ R+ VW VS + GN+FV
Sbjct: 377 TLQAFDSHYDYTICGDSEDM-VCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFV 435
Query: 427 ICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQ 486
+ + + + + +L AD MG+YL +I DL EY HA W C
Sbjct: 436 LLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCN 495
Query: 487 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCR-TITVLILIWITGFIVAFI 545
G + ++E+SV LT +TLE++ I + R R + R +++ W+ F++A +
Sbjct: 496 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALL 555
Query: 546 PLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYS 605
PL + Y +C P+ DTE+ A Y V + L +N+ AF+I+ Y ++ +
Sbjct: 556 PLVG----ISSYAKVSICLPM---DTETPLALAYIVFV-LTLNIVAFVIVCCCYVKIYIT 607
Query: 606 VHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWV 665
V N K+ +AKR ++FTD +C PI ++L + T+++
Sbjct: 608 VRNPQY------NPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLI-TVSNSK 660
Query: 666 VIFIL--PINSALNPILYTLTTRPFK 689
++ +L P+NS NP LY + T+ F+
Sbjct: 661 ILLVLFYPLNSCANPFLYAIFTKAFQ 686
Score = 42.4 bits (98), Expect = 0.002
Identities = 43/215 (20%), Positives = 97/215 (45%), Gaps = 7/215 (3%)
Query: 117 NLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQ-NNKITSISIYAFRGLNS 175
+++ +PS+ + + L +R +P F N ++ ++Y+ + + + ++F L+
Sbjct: 43 DIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSK 102
Query: 176 LTKLYLSHNR-ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPT-FYGLNSLILLVLMNN- 232
+T + + + R +T++ P ++L L++L I + L T Y + +L + +N
Sbjct: 103 VTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNP 162
Query: 233 VLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNK-INHLNENTF 291
+T +P L L N +++ F + + L + + KNK + ++++ F
Sbjct: 163 YMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAF-NGTKLDAVYLNKNKYLTVIDKDAF 221
Query: 292 APLQKLDE-LDLGSNKIENLPPLIFKDLKELSQLN 325
+ LD+ + LP + LKEL N
Sbjct: 222 GGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARN 256
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 124 bits (311), Expect = 3e-28
Identities = 94/277 (33%), Positives = 132/277 (47%), Gaps = 9/277 (3%)
Query: 101 PVQCLCQGLE-LDCDETNLRAVPSVSS-----NVTAMSLQWNLIRKLPPDCFKNYHDLQK 154
P +C CQ + L C LR VP SS +V SL N I + F L++
Sbjct: 28 PERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRR 87
Query: 155 LYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRIS 214
L LQ N+I S+ F L+ L +LYL +N + L PG L +L L N +SR+S
Sbjct: 88 LDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLS 147
Query: 215 PPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLT 274
+F GL SL+ L L N L LPD + L +L LE N I L F L
Sbjct: 148 RGSFEGLESLVKLRLDGNALGALPDAVFAP-LGNLLYLHLESNRIRFLGKNAFAQLGKLR 206
Query: 275 VLVMRKNKI--NHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ 332
L + N++ + + TFAPL+ L L L +N +++L P IF+ L L L+L N +
Sbjct: 207 FLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLT 266
Query: 333 KIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNL 369
+ F L L+ L LEG +S + + PL +L
Sbjct: 267 HLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSL 303
Score = 70.1 bits (170), Expect = 7e-12
Identities = 47/131 (35%), Positives = 72/131 (54%), Gaps = 1/131 (0%)
Query: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
+++++ L N ++ L P F++ L L L+ N++T ++ AF GL +L +L L NR+
Sbjct: 230 SLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRL 289
Query: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHM 246
+ L + E LH LE L + N LS + P TF L L L L NN L+ L +
Sbjct: 290 SQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSAL-SGDIFAAS 348
Query: 247 PRLHWLDLEGN 257
P L+ LDL+GN
Sbjct: 349 PALYRLDLDGN 359
Score = 62.4 bits (150), Expect = 2e-09
Identities = 38/122 (31%), Positives = 62/122 (50%)
Query: 254 LEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPL 313
L GN I N+ F L L ++ N+I L+ TF L +L+EL LG+N ++ L P
Sbjct: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
Query: 314 IFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIY 373
L++L L + N I ++ F+ L L L L+G + + +F PL NL +++
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
Query: 374 FK 375
+
Sbjct: 186 LE 187
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 119 bits (299), Expect = 8e-27
Identities = 81/272 (29%), Positives = 140/272 (51%), Gaps = 6/272 (2%)
Query: 106 CQGL-ELDCDETNLRAVPSVSSN----VTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNN 160
C L EL +L +P + + +T ++L N + + P F++ +LQ L L N
Sbjct: 154 CSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYEN 213
Query: 161 KITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYG 220
++T I + F GL +L +L L N+I L PG+F + H L+ L + +NH+S++ P F
Sbjct: 214 RLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQ 273
Query: 221 LNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRK 280
L L L L N L L + MP L L L NHI +L + F + L VL++ +
Sbjct: 274 LPQLNRLTLFGNSLKEL-SLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSR 332
Query: 281 NKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFD 340
N+I+ ++ F L +L EL L +N +++L +F+ L L ++L N ++++ N F
Sbjct: 333 NQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFA 392
Query: 341 YLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
+ L ++ L+ ++ N+ +F L L +
Sbjct: 393 NVNGLMAIQLQNNQLENLPLGIFDHLGKLCEL 424
Score = 117 bits (294), Expect = 3e-26
Identities = 81/256 (31%), Positives = 128/256 (50%), Gaps = 1/256 (0%)
Query: 123 SVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLS 182
S SN+ + L N + +P F + L KL L N +T IS F+ L +L L L
Sbjct: 152 SQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLY 211
Query: 183 HNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPL 242
NR+T + G F+ L L+ L ++ N + +SP F+ ++L L L NN +++LP
Sbjct: 212 ENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIF 271
Query: 243 CQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDL 302
Q +P+L+ L L GN + L F NL L + N I+ L +N F+ L++L L L
Sbjct: 272 MQ-LPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL 330
Query: 303 GSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRM 362
N+I + P F L EL +L+L N +Q + N F L L+++SL+ + + +
Sbjct: 331 SRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNI 390
Query: 363 FRPLMNLSHIYFKKFQ 378
F + L I + Q
Sbjct: 391 FANVNGLMAIQLQNNQ 406
Score = 114 bits (286), Expect = 3e-25
Identities = 92/311 (29%), Positives = 150/311 (48%), Gaps = 12/311 (3%)
Query: 101 PVQCLC-QGLELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQ 158
P +C C + +++C + AVP+ + N ++ + I +L F N L L ++
Sbjct: 32 PSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIE 91
Query: 159 NNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTF 218
N+++ I+ AFR L SL L L++N++ L G+F+ L LE L++ N L +I P F
Sbjct: 92 KNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHF 151
Query: 219 YGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVM 278
++L L L N L +PD H+ L L+L N + ++ F NL VL +
Sbjct: 152 SQCSNLKELQLHGNHLEYIPDGAF-DHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 210
Query: 279 RKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQ 338
+N++ + TF L L EL L N+I L P +F + L +L LS N I ++ +
Sbjct: 211 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSI 270
Query: 339 FDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISS 398
F L +L L+L G + + +F P+ NL ++ Y H+ S N S+
Sbjct: 271 FMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWL-------YDNHISSLPDNV--FSN 321
Query: 399 LENLLASIIQR 409
L L I+ R
Sbjct: 322 LRQLQVLILSR 332
Score = 112 bits (280), Expect = 1e-24
Identities = 82/270 (30%), Positives = 131/270 (48%), Gaps = 2/270 (0%)
Query: 116 TNLRAVPSVS-SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLN 174
T L P ++ S + A+ ++ N + ++ P F+N L+ L L NNK+ + I F+GL+
Sbjct: 72 TELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLD 131
Query: 175 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL 234
SL L LS N++ ++P F L+ L + NHL I F L L L L N L
Sbjct: 132 SLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSL 191
Query: 235 TRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPL 294
T + + + QH+ L L L N + ++ TF NL L +++N+I L+ F
Sbjct: 192 THISPR-VFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNN 250
Query: 295 QKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIE 354
L L L +N I LPP IF L +L++L L N ++++ F + L+ L L
Sbjct: 251 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 310
Query: 355 ISNIQQRMFRPLMNLSHIYFKKFQYCGYAP 384
IS++ +F L L + + Q +P
Sbjct: 311 ISSLPDNVFSNLRQLQVLILSRNQISFISP 340
Score = 101 bits (251), Expect = 3e-21
Identities = 67/204 (32%), Positives = 102/204 (50%), Gaps = 1/204 (0%)
Query: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
N+ ++LQ N I L P F N H+LQ+LYL NN I+ + F L L +L L N +
Sbjct: 228 NLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSL 287
Query: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHM 246
L G+F + L L + DNH+S + F L L +L+L N ++ + +
Sbjct: 288 KELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAF-NGL 346
Query: 247 PRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNK 306
L L L N + +L F +NL + ++ N++ L N FA + L + L +N+
Sbjct: 347 TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQ 406
Query: 307 IENLPPLIFKDLKELSQLNLSYNP 330
+ENLP IF L +L +L L NP
Sbjct: 407 LENLPLGIFDHLGKLCELRLYDNP 430
Score = 95.5 bits (236), Expect = 2e-19
Identities = 71/233 (30%), Positives = 106/233 (45%), Gaps = 1/233 (0%)
Query: 179 LYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLP 238
L + + IT L F ++ L L IE N LSRI+P F L SL L L NN L LP
Sbjct: 64 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 123
Query: 239 DKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLD 298
L Q + L L L N + ++ F CSNL L + N + ++ + F L L
Sbjct: 124 IG-LFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLT 182
Query: 299 ELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNI 358
+L+LG N + ++ P +F+ L L L L N + I FD LV L+ L+L+ +I +
Sbjct: 183 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLL 242
Query: 359 QQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVF 411
+F NL +Y P + P + ++ N L + +F
Sbjct: 243 SPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIF 295
Score = 65.5 bits (158), Expect = 2e-10
Identities = 48/165 (29%), Positives = 71/165 (43%)
Query: 252 LDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLP 311
L + HI L F++ S L L + KN+++ + F L L L L +NK++ LP
Sbjct: 64 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 123
Query: 312 PLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSH 371
+F+ L L L LS N + +IQ F LK L L G + I F L+ L+
Sbjct: 124 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTK 183
Query: 372 IYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVS 416
+ K +P V N + EN L I F +V+
Sbjct: 184 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVN 228
Score = 40.0 bits (92), Expect = 0.008
Identities = 21/59 (35%), Positives = 35/59 (59%)
Query: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHN 184
+N+ +SLQ N +R+LP + F N + L + LQNN++ ++ + F L L +L L N
Sbjct: 371 ANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 119 bits (299), Expect = 8e-27
Identities = 81/272 (29%), Positives = 140/272 (51%), Gaps = 6/272 (2%)
Query: 106 CQGL-ELDCDETNLRAVPSVSSN----VTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNN 160
C L EL +L +P + + +T ++L N + + P F++ +LQ L L N
Sbjct: 148 CSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYEN 207
Query: 161 KITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYG 220
++T I + F GL +L +L L N+I L PG+F + H L+ L + +NH+S++ P F
Sbjct: 208 RLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQ 267
Query: 221 LNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRK 280
L L L L N L L + MP L L L NHI +L + F + L VL++ +
Sbjct: 268 LPQLNRLTLFGNSLKEL-SLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSR 326
Query: 281 NKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFD 340
N+I+ ++ F L +L EL L +N +++L +F+ L L ++L N ++++ N F
Sbjct: 327 NQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFA 386
Query: 341 YLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
+ L ++ L+ ++ N+ +F L L +
Sbjct: 387 NVNGLMAIQLQNNQLENLPLGIFDHLGKLCEL 418
Score = 117 bits (294), Expect = 3e-26
Identities = 81/256 (31%), Positives = 128/256 (50%), Gaps = 1/256 (0%)
Query: 123 SVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLS 182
S SN+ + L N + +P F + L KL L N +T IS F+ L +L L L
Sbjct: 146 SQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLY 205
Query: 183 HNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPL 242
NR+T + G F+ L L+ L ++ N + +SP F+ ++L L L NN +++LP
Sbjct: 206 ENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIF 265
Query: 243 CQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDL 302
Q +P+L+ L L GN + L F NL L + N I+ L +N F+ L++L L L
Sbjct: 266 MQ-LPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL 324
Query: 303 GSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRM 362
N+I + P F L EL +L+L N +Q + N F L L+++SL+ + + +
Sbjct: 325 SRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNI 384
Query: 363 FRPLMNLSHIYFKKFQ 378
F + L I + Q
Sbjct: 385 FANVNGLMAIQLQNNQ 400
Score = 114 bits (286), Expect = 3e-25
Identities = 92/311 (29%), Positives = 150/311 (48%), Gaps = 12/311 (3%)
Query: 101 PVQCLC-QGLELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQ 158
P +C C + +++C + AVP+ + N ++ + I +L F N L L ++
Sbjct: 26 PSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIE 85
Query: 159 NNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTF 218
N+++ I+ AFR L SL L L++N++ L G+F+ L LE L++ N L +I P F
Sbjct: 86 KNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHF 145
Query: 219 YGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVM 278
++L L L N L +PD H+ L L+L N + ++ F NL VL +
Sbjct: 146 SQCSNLKELQLHGNHLEYIPDGAF-DHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 204
Query: 279 RKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQ 338
+N++ + TF L L EL L N+I L P +F + L +L LS N I ++ +
Sbjct: 205 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSI 264
Query: 339 FDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISS 398
F L +L L+L G + + +F P+ NL ++ Y H+ S N S+
Sbjct: 265 FMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWL-------YDNHISSLPDNV--FSN 315
Query: 399 LENLLASIIQR 409
L L I+ R
Sbjct: 316 LRQLQVLILSR 326
Score = 112 bits (280), Expect = 1e-24
Identities = 82/270 (30%), Positives = 131/270 (48%), Gaps = 2/270 (0%)
Query: 116 TNLRAVPSVS-SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLN 174
T L P ++ S + A+ ++ N + ++ P F+N L+ L L NNK+ + I F+GL+
Sbjct: 66 TELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLD 125
Query: 175 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL 234
SL L LS N++ ++P F L+ L + NHL I F L L L L N L
Sbjct: 126 SLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSL 185
Query: 235 TRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPL 294
T + + + QH+ L L L N + ++ TF NL L +++N+I L+ F
Sbjct: 186 THISPR-VFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNN 244
Query: 295 QKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIE 354
L L L +N I LPP IF L +L++L L N ++++ F + L+ L L
Sbjct: 245 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 304
Query: 355 ISNIQQRMFRPLMNLSHIYFKKFQYCGYAP 384
IS++ +F L L + + Q +P
Sbjct: 305 ISSLPDNVFSNLRQLQVLILSRNQISFISP 334
Score = 101 bits (251), Expect = 3e-21
Identities = 67/204 (32%), Positives = 102/204 (50%), Gaps = 1/204 (0%)
Query: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
N+ ++LQ N I L P F N H+LQ+LYL NN I+ + F L L +L L N +
Sbjct: 222 NLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSL 281
Query: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHM 246
L G+F + L L + DNH+S + F L L +L+L N ++ + +
Sbjct: 282 KELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAF-NGL 340
Query: 247 PRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNK 306
L L L N + +L F +NL + ++ N++ L N FA + L + L +N+
Sbjct: 341 TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQ 400
Query: 307 IENLPPLIFKDLKELSQLNLSYNP 330
+ENLP IF L +L +L L NP
Sbjct: 401 LENLPLGIFDHLGKLCELRLYDNP 424
Score = 95.5 bits (236), Expect = 2e-19
Identities = 71/233 (30%), Positives = 106/233 (45%), Gaps = 1/233 (0%)
Query: 179 LYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLP 238
L + + IT L F ++ L L IE N LSRI+P F L SL L L NN L LP
Sbjct: 58 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 117
Query: 239 DKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLD 298
L Q + L L L N + ++ F CSNL L + N + ++ + F L L
Sbjct: 118 IG-LFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLT 176
Query: 299 ELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNI 358
+L+LG N + ++ P +F+ L L L L N + I FD LV L+ L+L+ +I +
Sbjct: 177 KLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLL 236
Query: 359 QQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVF 411
+F NL +Y P + P + ++ N L + +F
Sbjct: 237 SPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIF 289
Score = 65.5 bits (158), Expect = 2e-10
Identities = 48/165 (29%), Positives = 71/165 (43%)
Query: 252 LDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLP 311
L + HI L F++ S L L + KN+++ + F L L L L +NK++ LP
Sbjct: 58 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 117
Query: 312 PLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSH 371
+F+ L L L LS N + +IQ F LK L L G + I F L+ L+
Sbjct: 118 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTK 177
Query: 372 IYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVS 416
+ K +P V N + EN L I F +V+
Sbjct: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVN 222
Score = 40.0 bits (92), Expect = 0.008
Identities = 21/59 (35%), Positives = 35/59 (59%)
Query: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHN 184
+N+ +SLQ N +R+LP + F N + L + LQNN++ ++ + F L L +L L N
Sbjct: 365 ANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 119 bits (298), Expect = 1e-26
Identities = 89/308 (28%), Positives = 144/308 (46%), Gaps = 33/308 (10%)
Query: 96 LVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKL 155
++G V LC G +++C L ++P T L
Sbjct: 29 ILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVF-----------------------L 65
Query: 156 YLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISP 215
YL N I+ I+ GL+SL LYL ++ I ++ P F L L +L + +N + R+ P
Sbjct: 66 YLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDP 125
Query: 216 PTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTV 275
F GL +L L L N ++ +P + + + + +L+L+ N + L + TF+ L +
Sbjct: 126 GIFKGLLNLRNLYLQYNQVSFVP-RGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
Query: 276 LVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQ 335
L + N I ++E+ F L+ L L LGSN + +P F+ LK L +L+LS+NPI+ IQ
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 336 ANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDG 395
F L L+ L L+ I N+ + F + NL H+ H N+D
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILS---------HNDLENLNSDT 295
Query: 396 ISSLENLL 403
S L+NL+
Sbjct: 296 FSLLKNLI 303
Score = 110 bits (275), Expect = 5e-24
Identities = 75/238 (31%), Positives = 121/238 (50%), Gaps = 2/238 (0%)
Query: 136 NLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFE 195
N I++L P FK +L+ LYLQ N+++ + F L S+ L L NR+T L G F
Sbjct: 118 NFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFV 177
Query: 196 DLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLE 255
+ L L + +N++ RIS F L +L L L +N LT++P + + L L L
Sbjct: 178 GMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAF-EVLKSLRRLSLS 236
Query: 256 GNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIF 315
N I ++ F +NL L+++ ++I ++ + F+ + L L L N +ENL F
Sbjct: 237 HNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTF 296
Query: 316 KDLKELSQLNLSYNPIQKIQANQFDYL-VKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
LK L L L N I I + F+ + LK L+L ++ + R+ +PL +L H+
Sbjct: 297 SLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHL 354
Score = 62.8 bits (151), Expect = 1e-09
Identities = 50/183 (27%), Positives = 84/183 (45%), Gaps = 26/183 (14%)
Query: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
N+ + L N + K+P + F+ L++L L +N I +I +AF+GL +L L L ++RI
Sbjct: 205 NLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRI 264
Query: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHM 246
+ F ++ L+ LI+ N L ++ TF L +LI
Sbjct: 265 RNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLI--------------------- 303
Query: 247 PRLHWLDLEGNHIHNLRNLTFISC-SNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
+L L+ N I ++ N TF + ++L +L + N + L+ PL L L SN
Sbjct: 304 ----YLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
Query: 306 KIE 308
E
Sbjct: 360 PWE 362
Score = 60.8 bits (146), Expect = 4e-09
Identities = 45/131 (34%), Positives = 67/131 (51%), Gaps = 5/131 (3%)
Query: 117 NLRAVPS----VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRG 172
NL VPS V ++ +SL N I + P FK +L+ L L+N++I +++ F G
Sbjct: 215 NLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSG 274
Query: 173 LNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLN-SLILLVLMN 231
+N+L L LSHN + L F L L +L ++ N + I TF + SL +L L
Sbjct: 275 INNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSF 334
Query: 232 NVLTRLPDKPL 242
N LT L + L
Sbjct: 335 NNLTALHPRVL 345
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 116 bits (290), Expect = 9e-26
Identities = 83/273 (30%), Positives = 136/273 (49%), Gaps = 2/273 (0%)
Query: 101 PVQCLCQGLELDCDETNLRAVPSVSSNVT-AMSLQWNLIRKLPPDCFKNYHDLQKLYLQN 159
P +C C+ L CD +VP+ + + +SL+ N I +L D F ++ L L+L +
Sbjct: 35 PPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDH 94
Query: 160 NKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFY 219
N+I+++ AF+GL L +L LS N+I +L F L L+ L + N LS + P FY
Sbjct: 95 NQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFY 154
Query: 220 GLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMR 279
GL L L L +N L +P + L L +LDL N + +L F L L +
Sbjct: 155 GLRKLQTLHLRSNSLRTIPVR-LFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLE 213
Query: 280 KNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQF 339
N++ +N F L L L L NKI NL + L +L+L+ N I+ I F
Sbjct: 214 HNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVF 273
Query: 340 DYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
+ + LK L ++ +++++ ++ L +L+ +
Sbjct: 274 ETMPNLKILLMDNNKLNSLDSKILNSLRSLTTV 306
Score = 75.5 bits (184), Expect = 2e-13
Identities = 57/179 (31%), Positives = 86/179 (48%), Gaps = 1/179 (0%)
Query: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
N+ + L +N + L P+ F LQ L+L++N + +I + F SL L LS NR+
Sbjct: 134 NLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRL 193
Query: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHM 246
L F L +L L +E N L++I+ F L+SL L L N ++ L +
Sbjct: 194 RSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCG-MEWTW 252
Query: 247 PRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
L LDL GN I + F + NL +L+M NK+N L+ L+ L + L N
Sbjct: 253 GTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
Score = 62.0 bits (149), Expect = 2e-09
Identities = 43/152 (28%), Positives = 72/152 (47%), Gaps = 1/152 (0%)
Query: 227 LVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHL 286
L L +N +T L ++ +L WL L+ N I ++ F L L++ NKI +L
Sbjct: 66 LSLRHNHITEL-ERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYL 124
Query: 287 NENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLK 346
TF L L LDL N++ +L P +F L++L L+L N ++ I F L+
Sbjct: 125 PNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLE 184
Query: 347 SLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQ 378
L L + ++ + F L+ L ++ + Q
Sbjct: 185 FLDLSTNRLRSLARNGFAGLIKLRELHLEHNQ 216
Score = 36.2 bits (82), Expect = 0.12
Identities = 22/83 (26%), Positives = 39/83 (46%)
Query: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
S++ + LQWN I L + L+KL L N+I +I + F + +L L + +N+
Sbjct: 229 SSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNK 288
Query: 186 ITFLKPGVFEDLHRLEWLIIEDN 208
+ L + L L + + N
Sbjct: 289 LNSLDSKILNSLRSLTTVGLSGN 311
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 115 bits (288), Expect = 2e-25
Identities = 161/699 (23%), Positives = 283/699 (40%), Gaps = 146/699 (20%)
Query: 114 DETNLRAVPSVSSN----VTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYA 169
D+ L +P + N + AM+L N I +P F+N L L+L NN+I + ++
Sbjct: 118 DDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHS 177
Query: 170 FRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYG--------- 220
F GL++L L L++N++ P L RL+ L +N++ I F G
Sbjct: 178 FEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 236
Query: 221 ------------------LNSLILLVLMN-------------NVLT------RLPDKPLC 243
L++L L M+ +LT RL +C
Sbjct: 237 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 296
Query: 244 QHMPRLHWLDLEGNHIHNLRNL----------------------TFISCSNLTVLVMRKN 281
Q +PRL L+L N I L +L TF S+L L + N
Sbjct: 297 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 356
Query: 282 KINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDY 341
I ++ F+ L L +LDL N++ LP L L L L N + QA D
Sbjct: 357 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN-LALSQAFSKDS 412
Query: 342 LVKLKSLSL------------------------EGIEISNIQQRMFRPLMNLSH------ 371
KL+ L + E + + + ++ RPL L+
Sbjct: 413 FPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDD-EESSKRPLGLLARQAENHY 471
Query: 372 ---IYFKKFQYCGYAPHVR-SCKPNTDGISSLENLLASIIQRVFVW--VVSAVTCFGNIF 425
+ + + PH C P E L S R+ VW V+ +V C G
Sbjct: 472 DQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNG--- 528
Query: 426 VICMRPYIRSENKLYAMSII--SLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMEST 483
++ + + L + + ++ A+ L GI ++ D G+++++ W
Sbjct: 529 LVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL 588
Query: 484 HCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRP-GKCRTI-----TVLILIWI 537
C+ G LA+L +E SVLLLT ++ + + CVR GK ++ VL + +
Sbjct: 589 GCRATGFLAVLGSEASVLLLTLAAVQCSVSV----SCVRAYGKSPSLGSVRAGVLGCLAL 644
Query: 538 TGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVF 597
G + A +PL++ YG + +C P + + A ++VA+ + +N F+++
Sbjct: 645 AG-LAAALPLAS----VGEYGASPLCLPYAPPEGQP-AALGFTVALVM-MNSFCFLVVAG 697
Query: 598 SYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQV-- 655
+Y ++ + + A + + + +++F D L + P+ + F S+L +
Sbjct: 698 AYIKLYCDLPRGDFEAV-------WDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 750
Query: 656 EIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHR 694
P + S V++ +LP+ + LNP+LY L F++ + R
Sbjct: 751 VTPEAVKS-VLLVVLPLPACLNPLLYLLFNPHFRDDLRR 788
Score = 92.0 bits (227), Expect = 2e-18
Identities = 92/306 (30%), Positives = 136/306 (44%), Gaps = 40/306 (13%)
Query: 97 VGSVPVQCL-----CQGLELDCDETNLRAVPSVS----SNVTAMSLQWNLIRKLPPDCFK 147
+G +P + L Q L LD + +L VP S S++ + L N + ++P
Sbjct: 74 LGGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTEIPVRALN 131
Query: 148 NYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIED 207
N LQ + L N+I+ I YAF+ L SL L+L +NRI L FE LH LE L +
Sbjct: 132 NLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNY 191
Query: 208 NHLSRISPPTFYGLNSLILLVLMNNVLTRLPDK-----PLC------------------Q 244
N L P L L L NN + +P+K PL Q
Sbjct: 192 NKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQ 250
Query: 245 HMPRLHWLDLEG-NHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLG 303
++P+LH L L G I +L ++L +L + + I L L +L L+L
Sbjct: 251 YLPKLHTLSLNGAMDIQEFPDLK--GTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 308
Query: 304 SNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMF 363
N+IE LP L ++L ++ L +N I +I A+ F L L++L L I +I F
Sbjct: 309 HNQIEELPSL--HRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAF 366
Query: 364 RPLMNL 369
L +L
Sbjct: 367 STLHSL 372
Score = 89.7 bits (221), Expect = 9e-18
Identities = 69/222 (31%), Positives = 101/222 (45%), Gaps = 2/222 (0%)
Query: 131 MSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLK 190
+ L N + +P F + L+ L LQNN++ I A L SL L L N I+ +
Sbjct: 43 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 102
Query: 191 PGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLH 250
FE L L L ++DN L+ I L +L + L N ++ +PD Q++ L
Sbjct: 103 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAF-QNLTSLV 161
Query: 251 WLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENL 310
L L N I +L +F NL L + NK+ L +L EL +N I+ +
Sbjct: 162 VLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAI 220
Query: 311 PPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEG 352
P F L ++ NPIQ + + F YL KL +LSL G
Sbjct: 221 PEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 262
Score = 87.4 bits (215), Expect = 4e-17
Identities = 77/263 (29%), Positives = 116/263 (44%), Gaps = 43/263 (16%)
Query: 181 LSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDK 240
LS N +T L+PG+F L LE L + NHLS I F GL SL +L+L NN L +P +
Sbjct: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
Query: 241 PLCQHMPRLHWLDLEGNHIHNLRNLTFISCSN------------------------LTVL 276
L + +P L L L+ N I + +F S+ L +
Sbjct: 81 ALWE-LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
Query: 277 VMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQA 336
+ N+I+H+ + F L L L L +N+I++L F+ L L L+L+YN +Q+
Sbjct: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199
Query: 337 NQFDYLVKLKSLSLEGIEISNIQQRMF--RPLMNLSHIYFKKFQYCG-----YAPHVRSC 389
L +L+ L I I ++ F PL+ H Y Q+ G Y P + +
Sbjct: 200 -AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTL 258
Query: 390 K----------PNTDGISSLENL 402
P+ G +SLE L
Sbjct: 259 SLNGAMDIQEFPDLKGTTSLEIL 281
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 115 bits (288), Expect = 2e-25
Identities = 161/699 (23%), Positives = 283/699 (40%), Gaps = 146/699 (20%)
Query: 114 DETNLRAVPSVSSN----VTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYA 169
D+ L +P + N + AM+L N I +P F+N L L+L NN+I + ++
Sbjct: 170 DDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHS 229
Query: 170 FRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYG--------- 220
F GL++L L L++N++ P L RL+ L +N++ I F G
Sbjct: 230 FEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 288
Query: 221 ------------------LNSLILLVLMN-------------NVLT------RLPDKPLC 243
L++L L M+ +LT RL +C
Sbjct: 289 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 348
Query: 244 QHMPRLHWLDLEGNHIHNLRNL----------------------TFISCSNLTVLVMRKN 281
Q +PRL L+L N I L +L TF S+L L + N
Sbjct: 349 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 408
Query: 282 KINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDY 341
I ++ F+ L L +LDL N++ LP L L L L N + QA D
Sbjct: 409 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN-LALSQAFSKDS 464
Query: 342 LVKLKSLSL------------------------EGIEISNIQQRMFRPLMNLSH------ 371
KL+ L + E + + + ++ RPL L+
Sbjct: 465 FPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDD-EESSKRPLGLLARQAENHY 523
Query: 372 ---IYFKKFQYCGYAPHVR-SCKPNTDGISSLENLLASIIQRVFVW--VVSAVTCFGNIF 425
+ + + PH C P E L S R+ VW V+ +V C G
Sbjct: 524 DQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNG--- 580
Query: 426 VICMRPYIRSENKLYAMSII--SLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMEST 483
++ + + L + + ++ A+ L GI ++ D G+++++ W
Sbjct: 581 LVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL 640
Query: 484 HCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRP-GKCRTI-----TVLILIWI 537
C+ G LA+L +E SVLLLT ++ + + CVR GK ++ VL + +
Sbjct: 641 GCRATGFLAVLGSEASVLLLTLAAVQCSVSV----SCVRAYGKSPSLGSVRAGVLGCLAL 696
Query: 538 TGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVF 597
G + A +PL++ YG + +C P + + A ++VA+ + +N F+++
Sbjct: 697 AG-LAAALPLAS----VGEYGASPLCLPYAPPEGQP-AALGFTVALVM-MNSFCFLVVAG 749
Query: 598 SYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQV-- 655
+Y ++ + + A + + + +++F D L + P+ + F S+L +
Sbjct: 750 AYIKLYCDLPRGDFEAV-------WDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 802
Query: 656 EIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHR 694
P + S V++ +LP+ + LNP+LY L F++ + R
Sbjct: 803 VTPEAVKS-VLLVVLPLPACLNPLLYLLFNPHFRDDLRR 840
Score = 95.9 bits (237), Expect = 1e-19
Identities = 83/281 (29%), Positives = 116/281 (41%), Gaps = 31/281 (11%)
Query: 101 PVQCLCQG----LELDCDETNLRAVPSVSSNVTA-------------------------M 131
P C CQ L DC E L AVP +TA +
Sbjct: 36 PAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEEL 95
Query: 132 SLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKP 191
L N + +P F + L+ L LQNN++ I A L SL L L N I+ +
Sbjct: 96 RLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPE 155
Query: 192 GVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHW 251
FE L L L ++DN L+ I L +L + L N ++ +PD Q++ L
Sbjct: 156 RSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAF-QNLTSLVV 214
Query: 252 LDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLP 311
L L N I +L +F NL L + NK+ L +L EL +N I+ +P
Sbjct: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIP 273
Query: 312 PLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEG 352
F L ++ NPIQ + + F YL KL +LSL G
Sbjct: 274 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 314
Score = 92.0 bits (227), Expect = 2e-18
Identities = 92/306 (30%), Positives = 136/306 (44%), Gaps = 40/306 (13%)
Query: 97 VGSVPVQCL-----CQGLELDCDETNLRAVPSVS----SNVTAMSLQWNLIRKLPPDCFK 147
+G +P + L Q L LD + +L VP S S++ + L N + ++P
Sbjct: 126 LGGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTEIPVRALN 183
Query: 148 NYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIED 207
N LQ + L N+I+ I YAF+ L SL L+L +NRI L FE LH LE L +
Sbjct: 184 NLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNY 243
Query: 208 NHLSRISPPTFYGLNSLILLVLMNNVLTRLPDK-----PLC------------------Q 244
N L P L L L NN + +P+K PL Q
Sbjct: 244 NKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQ 302
Query: 245 HMPRLHWLDLEG-NHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLG 303
++P+LH L L G I +L ++L +L + + I L L +L L+L
Sbjct: 303 YLPKLHTLSLNGAMDIQEFPDLK--GTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 360
Query: 304 SNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMF 363
N+IE LP L ++L ++ L +N I +I A+ F L L++L L I +I F
Sbjct: 361 HNQIEELPSL--HRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAF 418
Query: 364 RPLMNL 369
L +L
Sbjct: 419 STLHSL 424
Score = 87.8 bits (216), Expect = 3e-17
Identities = 78/265 (29%), Positives = 117/265 (44%), Gaps = 43/265 (16%)
Query: 179 LYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLP 238
L LS N +T L+PG+F L LE L + NHLS I F GL SL +L+L NN L +P
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 239 DKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSN------------------------LT 274
+ L + +P L L L+ N I + +F S+ L
Sbjct: 131 AEALWE-LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQ 189
Query: 275 VLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKI 334
+ + N+I+H+ + F L L L L +N+I++L F+ L L L+L+YN +Q+
Sbjct: 190 AMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF 249
Query: 335 QANQFDYLVKLKSLSLEGIEISNIQQRMF--RPLMNLSHIYFKKFQYCG-----YAPHVR 387
L +L+ L I I ++ F PL+ H Y Q+ G Y P +
Sbjct: 250 PV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLH 308
Query: 388 SCK----------PNTDGISSLENL 402
+ P+ G +SLE L
Sbjct: 309 TLSLNGAMDIQEFPDLKGTTSLEIL 333
Score = 42.4 bits (98), Expect = 0.002
Identities = 38/142 (26%), Positives = 59/142 (41%), Gaps = 10/142 (7%)
Query: 247 PRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNK 306
P +LDL N++ L+ F L L + N ++H+ F+ L L L L +N+
Sbjct: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 125
Query: 307 IENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQ------- 359
+ +P +L L L L N I + F+ L L+ L L+ ++ I
Sbjct: 126 LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL 185
Query: 360 ---QRMFRPLMNLSHIYFKKFQ 378
Q M L +SHI FQ
Sbjct: 186 PALQAMTLALNRISHIPDYAFQ 207
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 114 bits (285), Expect = 3e-25
Identities = 92/293 (31%), Positives = 134/293 (45%), Gaps = 13/293 (4%)
Query: 87 PFEAETPECLVGSVPVQCLCQ------GLELDCDETNLRAVPS-VSSNVTAMSLQWNLIR 139
P EAE P C P C+C L + C NL +P V A+ L N +
Sbjct: 71 PGEAEGPAC-----PAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLS 125
Query: 140 KLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHR 199
+PP F+N L L LQ ++ S+ A GL +L L+L N++ L G F
Sbjct: 126 SVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPA 185
Query: 200 LEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHI 259
L L + +N LSR+ F GL SL L L N L LPD + + L L L GN +
Sbjct: 186 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF-RGLGSLRELVLAGNRL 244
Query: 260 HNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLK 319
L+ F + L L + +N + + N F L +L +L L N I + P F LK
Sbjct: 245 AYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLK 304
Query: 320 ELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
L L+LS+N + + + F L+ L+ L L I++++ R F+ L L +
Sbjct: 305 ALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEEL 357
Score = 111 bits (278), Expect = 2e-24
Identities = 79/272 (29%), Positives = 123/272 (45%), Gaps = 31/272 (11%)
Query: 131 MSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLK 190
++L WN + LP F+ L++L L N++ + F GL L +L LS N + +K
Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
Query: 191 PGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLH 250
VF L RL+ L ++ N ++ ++P F GL +L
Sbjct: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKAL-------------------------R 307
Query: 251 WLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENL 310
WLDL N + L TF L VL + N I L TF L L+EL LG N+I L
Sbjct: 308 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 367
Query: 311 PPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLS 370
F+ L +L L L +N +Q+++A F L + ++L G + N+ +++FR L L
Sbjct: 368 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 427
Query: 371 HIYFKKFQYCGYAPHVRSCKPNTDGISSLENL 402
++ + PH + G+S L L
Sbjct: 428 SLHLEGSCLGRIRPHTFT------GLSGLRRL 453
Score = 107 bits (268), Expect = 3e-23
Identities = 79/275 (28%), Positives = 134/275 (48%), Gaps = 6/275 (2%)
Query: 115 ETNLRAVPSVSSNVTAMSLQW-----NLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYA 169
+ NL A + + + +L+W N + L D F L+ L L +N I S+
Sbjct: 288 DRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRT 347
Query: 170 FRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVL 229
F+ L+ L +L L HNRI L FE L +LE L ++ N L + F GL ++ ++ L
Sbjct: 348 FKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNL 407
Query: 230 MNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNEN 289
N L LP++ + + + +LH L LEG+ + +R TF S L L ++ N + + E
Sbjct: 408 SGNCLRNLPEQ-VFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQ 466
Query: 290 TFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLS 349
+ L +L ELDL SN++ +LP +F+ L +L L LS N + ++ A+ L + L
Sbjct: 467 SLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLD 526
Query: 350 LEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAP 384
+ + + + PL L ++ + + P
Sbjct: 527 VSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 561
Score = 72.0 bits (175), Expect = 2e-12
Identities = 61/206 (29%), Positives = 90/206 (43%), Gaps = 9/206 (4%)
Query: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
+NV M+L N +R LP F+ L L+L+ + + I + F GL+ L +L+L N
Sbjct: 400 TNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNG 459
Query: 186 ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQH 245
+ ++ L L L + N L+ + F GL L L+L N L LP L
Sbjct: 460 LVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADAL-GP 518
Query: 246 MPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQK-LDELDLGS 304
+ R WLD+ N + L N L L +R N + TF P L+ L L
Sbjct: 519 LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL-----RTFTPQPPGLERLWLEG 573
Query: 305 NKIENLPPLIFKDLKELSQLNLSYNP 330
N + PL K L++ + N S P
Sbjct: 574 NPWDCGCPL--KALRDFALQNPSAVP 597
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 114 bits (285), Expect = 3e-25
Identities = 92/293 (31%), Positives = 134/293 (45%), Gaps = 13/293 (4%)
Query: 87 PFEAETPECLVGSVPVQCLCQ------GLELDCDETNLRAVPS-VSSNVTAMSLQWNLIR 139
P EAE P C P C+C L + C NL +P V A+ L N +
Sbjct: 33 PGEAEGPAC-----PAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLS 87
Query: 140 KLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHR 199
+PP F+N L L LQ ++ S+ A GL +L L+L N++ L G F
Sbjct: 88 SVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPA 147
Query: 200 LEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHI 259
L L + +N LSR+ F GL SL L L N L LPD + + L L L GN +
Sbjct: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF-RGLGSLRELVLAGNRL 206
Query: 260 HNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLK 319
L+ F + L L + +N + + N F L +L +L L N I + P F LK
Sbjct: 207 AYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLK 266
Query: 320 ELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
L L+LS+N + + + F L+ L+ L L I++++ R F+ L L +
Sbjct: 267 ALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEEL 319
Score = 111 bits (278), Expect = 2e-24
Identities = 79/272 (29%), Positives = 123/272 (45%), Gaps = 31/272 (11%)
Query: 131 MSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLK 190
++L WN + LP F+ L++L L N++ + F GL L +L LS N + +K
Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
Query: 191 PGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLH 250
VF L RL+ L ++ N ++ ++P F GL +L
Sbjct: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKAL-------------------------R 269
Query: 251 WLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENL 310
WLDL N + L TF L VL + N I L TF L L+EL LG N+I L
Sbjct: 270 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 329
Query: 311 PPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLS 370
F+ L +L L L +N +Q+++A F L + ++L G + N+ +++FR L L
Sbjct: 330 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 389
Query: 371 HIYFKKFQYCGYAPHVRSCKPNTDGISSLENL 402
++ + PH + G+S L L
Sbjct: 390 SLHLEGSCLGRIRPHTFT------GLSGLRRL 415
Score = 107 bits (268), Expect = 3e-23
Identities = 79/275 (28%), Positives = 134/275 (48%), Gaps = 6/275 (2%)
Query: 115 ETNLRAVPSVSSNVTAMSLQW-----NLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYA 169
+ NL A + + + +L+W N + L D F L+ L L +N I S+
Sbjct: 250 DRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRT 309
Query: 170 FRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVL 229
F+ L+ L +L L HNRI L FE L +LE L ++ N L + F GL ++ ++ L
Sbjct: 310 FKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNL 369
Query: 230 MNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNEN 289
N L LP++ + + + +LH L LEG+ + +R TF S L L ++ N + + E
Sbjct: 370 SGNCLRNLPEQ-VFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQ 428
Query: 290 TFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLS 349
+ L +L ELDL SN++ +LP +F+ L +L L LS N + ++ A+ L + L
Sbjct: 429 SLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLD 488
Query: 350 LEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAP 384
+ + + + PL L ++ + + P
Sbjct: 489 VSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 523
Score = 72.0 bits (175), Expect = 2e-12
Identities = 61/206 (29%), Positives = 90/206 (43%), Gaps = 9/206 (4%)
Query: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
+NV M+L N +R LP F+ L L+L+ + + I + F GL+ L +L+L N
Sbjct: 362 TNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNG 421
Query: 186 ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQH 245
+ ++ L L L + N L+ + F GL L L+L N L LP L
Sbjct: 422 LVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADAL-GP 480
Query: 246 MPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQK-LDELDLGS 304
+ R WLD+ N + L N L L +R N + TF P L+ L L
Sbjct: 481 LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL-----RTFTPQPPGLERLWLEG 535
Query: 305 NKIENLPPLIFKDLKELSQLNLSYNP 330
N + PL K L++ + N S P
Sbjct: 536 NPWDCGCPL--KALRDFALQNPSAVP 559
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 114 bits (285), Expect = 3e-25
Identities = 78/227 (34%), Positives = 116/227 (51%), Gaps = 1/227 (0%)
Query: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
+++ ++L NL+ +LP + F LQ L L NN ++ + F L SL +L+L N
Sbjct: 169 THLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNN 228
Query: 186 ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQH 245
I+ L P VF L LE L ++ N ++ + F L +L L L N+L LP L H
Sbjct: 229 ISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLP-AGLFAH 287
Query: 246 MPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
P L L L N + + TF SNL L++ N I HL F L++L +L LGSN
Sbjct: 288 TPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSN 347
Query: 306 KIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEG 352
+ L P +F++L +L L+LS N + + FD L +L+L G
Sbjct: 348 NLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHG 394
Score = 102 bits (255), Expect = 1e-21
Identities = 77/243 (31%), Positives = 119/243 (48%), Gaps = 1/243 (0%)
Query: 130 AMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFL 189
++ LQ N ++ LP F+ L+ L L N + + F L SL L LS+N ++ L
Sbjct: 149 SLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGL 208
Query: 190 KPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRL 249
GVF L L+ L ++ N++S + P F L L L L N +T LP + + L
Sbjct: 209 PQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLP-LSIFASLGNL 267
Query: 250 HWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIEN 309
+L L+ N + L F L L + N++ + E TFA L L L L N I +
Sbjct: 268 TFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITH 327
Query: 310 LPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNL 369
LP IF+DL+EL +L L N + + F L KL+ LSL +++ + + +F NL
Sbjct: 328 LPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNL 387
Query: 370 SHI 372
++
Sbjct: 388 FNL 390
Score = 90.9 bits (224), Expect = 4e-18
Identities = 76/271 (28%), Positives = 126/271 (46%), Gaps = 1/271 (0%)
Query: 141 LPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRL 200
L + F N L KL L N + ++ F+ L +L L+L N++ L +F+ L L
Sbjct: 112 LSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHL 171
Query: 201 EWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIH 260
+ L + N L+++ F+ L SL L L NN L+ LP + + + L L L+ N+I
Sbjct: 172 KTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP-QGVFGKLGSLQELFLDSNNIS 230
Query: 261 NLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKE 320
L F L L +++N I HL + FA L L L L N + LP +F
Sbjct: 231 ELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPC 290
Query: 321 LSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYC 380
L L+L++N ++ + F +L L+SL L I+++ +FR L L +Y
Sbjct: 291 LVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLT 350
Query: 381 GYAPHVRSCKPNTDGISSLENLLASIIQRVF 411
P + + +S +N L ++ + +F
Sbjct: 351 ALHPALFQNLSKLELLSLSKNQLTTLPEGIF 381
Score = 89.4 bits (220), Expect = 1e-17
Identities = 81/311 (26%), Positives = 129/311 (41%), Gaps = 24/311 (7%)
Query: 101 PVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNN 160
P+ C C E+ C + L VP +PP + +
Sbjct: 23 PMGCDCFVQEVFCSDEELATVPL----------------DIPPYT-------KNIIFVET 59
Query: 161 KITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYG 220
T++ AF +LTK+ + ++ +P F L RLE L + + +S F
Sbjct: 60 SFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSN 119
Query: 221 LNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRK 280
L SL L L N+L LP+ L QH+ L L L+GN + L F ++L L + +
Sbjct: 120 LTSLGKLTLNFNMLEALPEG-LFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQ 178
Query: 281 NKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFD 340
N + L E F PL L L L +N + LP +F L L +L L N I ++ F
Sbjct: 179 NLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFS 238
Query: 341 YLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLE 400
L L+ L L+ I+++ +F L NL+ + + + + P G+S
Sbjct: 239 QLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTH 298
Query: 401 NLLASIIQRVF 411
N L ++ + F
Sbjct: 299 NQLETVAEGTF 309
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/83 (34%), Positives = 48/83 (57%)
Query: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
SN+ ++ L +N I LP F++ +L KLYL +N +T++ F+ L+ L L LS N+
Sbjct: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372
Query: 186 ITFLKPGVFEDLHRLEWLIIEDN 208
+T L G+F+ + L L + N
Sbjct: 373 LTTLPEGIFDTNYNLFNLALHGN 395
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 114 bits (284), Expect = 4e-25
Identities = 82/245 (33%), Positives = 124/245 (50%), Gaps = 19/245 (7%)
Query: 131 MSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLK 190
+ L N+I + P F N +L+ L L+ N++ + + F GL++LTKL +S N+I L
Sbjct: 86 IDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILL 145
Query: 191 PGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLH 250
+F+DLH L+ L + DN L IS F GL SL L L LT +P + L H+ L
Sbjct: 146 DYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEAL-SHLRSLI 204
Query: 251 WLDLEGNHIHNLRNLTFISCSNLTVL---------VMRKNKINHLNENTFAPLQKLDELD 301
L L+ +I+N+ F +L L +M N + LN L L
Sbjct: 205 SLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLN---------LTSLS 255
Query: 302 LGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQR 361
+ + + +P L FK L L+ LNLSYNPI I+A F L++L+ L + G ++ I+
Sbjct: 256 VTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPH 315
Query: 362 MFRPL 366
F+ L
Sbjct: 316 SFQGL 320
Score = 76.6 bits (187), Expect = 8e-14
Identities = 69/275 (25%), Positives = 115/275 (41%), Gaps = 28/275 (10%)
Query: 101 PVQCLC--QGLELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYL 157
P +C C Q + C L A+P + + L N ++ + P+ F +Y L+++ L
Sbjct: 29 PARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDL 88
Query: 158 QNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPT 217
+N I ++ AF L +L L L NR+ + GVF L L L I +N +
Sbjct: 89 SDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKI------- 141
Query: 218 FYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLV 277
+ILL M Q + L L++ N + + + F +L L
Sbjct: 142 ------VILLDYM------------FQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLT 183
Query: 278 MRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQAN 337
+ K + + + L+ L L L I N+P FK L L L + Y P+ +
Sbjct: 184 LEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPA 243
Query: 338 QFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
Y + L SLS+ +S + F+ L+ L+H+
Sbjct: 244 NSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHL 278
Score = 55.8 bits (133), Expect = 1e-07
Identities = 37/129 (28%), Positives = 60/129 (46%)
Query: 247 PRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNK 306
P L +DL N I N+ F + NL L ++ N++ + F L L +LD+ NK
Sbjct: 81 PLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENK 140
Query: 307 IENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPL 366
I L +F+DL L L + N + I F L+ L+ L+LE ++ + L
Sbjct: 141 IVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHL 200
Query: 367 MNLSHIYFK 375
+L ++ K
Sbjct: 201 RSLISLHLK 209
Score = 54.7 bits (130), Expect = 3e-07
Identities = 35/105 (33%), Positives = 56/105 (53%), Gaps = 1/105 (0%)
Query: 135 WNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVF 194
W L+ +P + + L L + N ++++ AF+ L LT L LS+N I+ ++ G+F
Sbjct: 235 WPLLDMMPANSLYGLN-LTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMF 293
Query: 195 EDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPD 239
DL RL+ L I L I P +F GL L +L + N+L L +
Sbjct: 294 SDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEE 338
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/125 (28%), Positives = 60/125 (48%)
Query: 252 LDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLP 311
LDL N + ++ FIS L + + N I ++ F L L L L N+++ +P
Sbjct: 62 LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVP 121
Query: 312 PLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSH 371
+F L L++L++S N I + F L LKSL + ++ I R F L++L
Sbjct: 122 LGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQ 181
Query: 372 IYFKK 376
+ +K
Sbjct: 182 LTLEK 186
Score = 38.1 bits (87), Expect = 0.030
Identities = 29/108 (26%), Positives = 51/108 (47%)
Query: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
N+T++S+ + +P FK+ L L L N I++I F L L +L++ ++
Sbjct: 250 NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQL 309
Query: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL 234
++P F+ L L L + N L + F +L +L + NN L
Sbjct: 310 RTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 114 bits (284), Expect = 4e-25
Identities = 83/273 (30%), Positives = 132/273 (48%), Gaps = 2/273 (0%)
Query: 101 PVQCLCQGLELDCDETNLRAVP-SVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQN 159
P C C G + C+ +P ++S +SL++N I+KL + F + L LYL +
Sbjct: 35 PKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDH 94
Query: 160 NKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFY 219
N I+S+ AF+G+ L +L LS N+IT+L F + L L + N L + F
Sbjct: 95 NYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFK 154
Query: 220 GLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMR 279
GL LI+L L +N L +P + + Q L +LDL N + +L F L L +
Sbjct: 155 GLRKLIILHLRSNSLKTVPIR-VFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLE 213
Query: 280 KNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQF 339
N+ + +N F L L + L N+I ++ + L L+LS N IQ I+ F
Sbjct: 214 HNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTF 273
Query: 340 DYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
L L+ L+L+ +++NI Q ++L I
Sbjct: 274 KCLPNLQKLNLDSNKLTNISQETVNAWISLISI 306
Score = 103 bits (258), Expect = 5e-22
Identities = 74/249 (29%), Positives = 119/249 (47%), Gaps = 3/249 (1%)
Query: 179 LYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLP 238
L L N I LK F L++L WL ++ N++S + F G+ L L+L +N +T L
Sbjct: 66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
Query: 239 DKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLD 298
+K +P L LDL N + L++ F L +L +R N + + F + LD
Sbjct: 126 NKTF-HPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLD 184
Query: 299 ELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNI 358
LDLG N++ +L F L +L +L+L +N KI F L L+S+ L+ I +I
Sbjct: 185 FLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSI 244
Query: 359 QQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQR-VFVWV-VS 416
Q + +L ++ G P C PN ++ N L +I Q V W+ +
Sbjct: 245 SQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLI 304
Query: 417 AVTCFGNIF 425
++T GN++
Sbjct: 305 SITLSGNMW 313
Score = 68.6 bits (166), Expect = 2e-11
Identities = 52/182 (28%), Positives = 86/182 (47%), Gaps = 1/182 (0%)
Query: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
N+ + L +N ++ L + FK L L+L++N + ++ I F+ +L L L +NR+
Sbjct: 134 NLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 193
Query: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHM 246
L F L +L+ L +E N S+I+ F L +L + L N + + + L
Sbjct: 194 RSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSI-SQGLTWTW 252
Query: 247 PRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNK 306
LH LDL GN I + TF NL L + NK+ ++++ T L + L N
Sbjct: 253 SSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNM 312
Query: 307 IE 308
E
Sbjct: 313 WE 314
Score = 53.5 bits (127), Expect = 7e-07
Identities = 50/167 (29%), Positives = 78/167 (46%), Gaps = 13/167 (7%)
Query: 99 SVPVQCLCQGLELDCDETNLRAVPSVSSNVTA-------MSLQWNLIRKLPPDCFKNYHD 151
+VP++ LD + + S+S N A + L+ N K+ F +
Sbjct: 171 TVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFN 230
Query: 152 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLS 211
L+ +YLQ N+I SIS +SL L LS N I ++PG F+ L L+ L ++ N L+
Sbjct: 231 LRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLT 290
Query: 212 RISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWL-DLEGN 257
IS T SLI + L N+ + +C P +WL + +GN
Sbjct: 291 NISQETVNAWISLISITLSGNMWE--CSRSIC---PLFYWLKNFKGN 332
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 114 bits (284), Expect = 4e-25
Identities = 83/273 (30%), Positives = 132/273 (48%), Gaps = 2/273 (0%)
Query: 101 PVQCLCQGLELDCDETNLRAVP-SVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQN 159
P C C G + C+ +P ++S +SL++N I+KL + F + L LYL +
Sbjct: 35 PKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDH 94
Query: 160 NKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFY 219
N I+S+ AF+G+ L +L LS N+IT+L F + L L + N L + F
Sbjct: 95 NYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFK 154
Query: 220 GLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMR 279
GL LI+L L +N L +P + + Q L +LDL N + +L F L L +
Sbjct: 155 GLRKLIILHLRSNSLKTVPIR-VFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLE 213
Query: 280 KNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQF 339
N+ + +N F L L + L N+I ++ + L L+LS N IQ I+ F
Sbjct: 214 HNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTF 273
Query: 340 DYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
L L+ L+L+ +++NI Q ++L I
Sbjct: 274 KCLPNLQKLNLDSNKLTNISQETVNAWISLISI 306
Score = 103 bits (258), Expect = 5e-22
Identities = 74/249 (29%), Positives = 119/249 (47%), Gaps = 3/249 (1%)
Query: 179 LYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLP 238
L L N I LK F L++L WL ++ N++S + F G+ L L+L +N +T L
Sbjct: 66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
Query: 239 DKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLD 298
+K +P L LDL N + L++ F L +L +R N + + F + LD
Sbjct: 126 NKTF-HPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLD 184
Query: 299 ELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNI 358
LDLG N++ +L F L +L +L+L +N KI F L L+S+ L+ I +I
Sbjct: 185 FLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSI 244
Query: 359 QQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQR-VFVWV-VS 416
Q + +L ++ G P C PN ++ N L +I Q V W+ +
Sbjct: 245 SQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLI 304
Query: 417 AVTCFGNIF 425
++T GN++
Sbjct: 305 SITLSGNMW 313
Score = 68.6 bits (166), Expect = 2e-11
Identities = 52/182 (28%), Positives = 86/182 (47%), Gaps = 1/182 (0%)
Query: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
N+ + L +N ++ L + FK L L+L++N + ++ I F+ +L L L +NR+
Sbjct: 134 NLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 193
Query: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHM 246
L F L +L+ L +E N S+I+ F L +L + L N + + + L
Sbjct: 194 RSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSI-SQGLTWTW 252
Query: 247 PRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNK 306
LH LDL GN I + TF NL L + NK+ ++++ T L + L N
Sbjct: 253 SSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNM 312
Query: 307 IE 308
E
Sbjct: 313 WE 314
Score = 53.5 bits (127), Expect = 7e-07
Identities = 50/167 (29%), Positives = 78/167 (46%), Gaps = 13/167 (7%)
Query: 99 SVPVQCLCQGLELDCDETNLRAVPSVSSNVTA-------MSLQWNLIRKLPPDCFKNYHD 151
+VP++ LD + + S+S N A + L+ N K+ F +
Sbjct: 171 TVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFN 230
Query: 152 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLS 211
L+ +YLQ N+I SIS +SL L LS N I ++PG F+ L L+ L ++ N L+
Sbjct: 231 LRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLT 290
Query: 212 RISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWL-DLEGN 257
IS T SLI + L N+ + +C P +WL + +GN
Sbjct: 291 NISQETVNAWISLISITLSGNMWE--CSRSIC---PLFYWLKNFKGN 332
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 112 bits (279), Expect = 2e-24
Identities = 92/307 (29%), Positives = 144/307 (46%), Gaps = 14/307 (4%)
Query: 101 PVQCLCQGLELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQN 159
P C C+G + C+ L+ +PS +S+ +SL++N ++KL + FK + L LYL +
Sbjct: 35 PKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDH 94
Query: 160 NKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFY 219
N I++I AF G+ L +L LS NRI++ F + L L + N L + F
Sbjct: 95 NHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFR 154
Query: 220 GLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMR 279
GL L+ L L +N L +P + + Q L LDL N I +L F L L +
Sbjct: 155 GLRKLLSLHLRSNSLRTIPVR-IFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLE 213
Query: 280 KNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQA-NQ 338
N+ + LN F L L L L NKI + + L +L+LS N I+ +
Sbjct: 214 HNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSV 273
Query: 339 FDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISS 398
F + L+ L+L+ +++ I Q + ++L+ I A ++ C N I S
Sbjct: 274 FQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDI--------SLAGNIWECSRN---ICS 322
Query: 399 LENLLAS 405
L N L S
Sbjct: 323 LVNWLKS 329
>gi|153251229 chondroadherin precursor [Homo sapiens]
Length = 359
Score = 106 bits (264), Expect = 9e-23
Identities = 74/282 (26%), Positives = 126/282 (44%), Gaps = 28/282 (9%)
Query: 97 VGSVPVQCLCQG--LELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQK 154
+ + P C C + CD+ L+ +P VS ++LQ N L + F+ +L
Sbjct: 20 LAACPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVS 79
Query: 155 LYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRIS 214
L+LQ+ +I ++ AFRGL L LYLSHN I L+ G F+DL L +L ++
Sbjct: 80 LHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLD-------- 131
Query: 215 PPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLT 274
+N +T LP + L + L L L N I LR F +L
Sbjct: 132 ----------------HNKVTELP-RGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLR 174
Query: 275 VLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKI 334
L + +N ++ L ++ L + + N++ + P L+ + +L LS+NP++ I
Sbjct: 175 WLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSI 234
Query: 335 QANQFDYLVK-LKSLSLEGIEISNIQQRMFRPLMNLSHIYFK 375
N F + L++L L+ + F + L H++ +
Sbjct: 235 PDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLE 276
Score = 70.1 bits (170), Expect = 7e-12
Identities = 50/180 (27%), Positives = 80/180 (44%), Gaps = 2/180 (1%)
Query: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
+ +T + L N + +LP +L L L NNKI + AF+G L LYLS N
Sbjct: 123 TELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENA 182
Query: 186 ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQH 245
++ L+PG +D+ L ++ N LS L + L L +N L +PD
Sbjct: 183 LSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSF 242
Query: 246 MPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
L L L+ ++ + F+ + L + + N++N L N P L+ L L +N
Sbjct: 243 GRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSN--FPFDSLETLALTNN 300
Score = 48.1 bits (113), Expect = 3e-05
Identities = 44/166 (26%), Positives = 65/166 (39%)
Query: 246 MPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
MP L L L+ I + F L L + N I L F L +L L L N
Sbjct: 74 MPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHN 133
Query: 306 KIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRP 365
K+ LP + L L L L+ N I++++A F L+ L L +S++Q
Sbjct: 134 KVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDD 193
Query: 366 LMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVF 411
+ NL+ + + Q Y S + + N L SI F
Sbjct: 194 VENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAF 239
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 105 bits (263), Expect = 1e-22
Identities = 82/273 (30%), Positives = 133/273 (48%), Gaps = 17/273 (6%)
Query: 111 LDCDETNLRAVPSVS----SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSIS 166
LD + NL +V +++ + ++ L+ N + +LP C +LQ+LY+ +N +++IS
Sbjct: 97 LDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTIS 156
Query: 167 IYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLIL 226
AF GL++L +L+L+ NR+ + F+ L LE L+I +N + RI F L +L
Sbjct: 157 PGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRS 216
Query: 227 LVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHL 286
LV+ LT +PD L + L + N + + ++ NL L + KN IN +
Sbjct: 217 LVIAGINLTEIPDNALV-GLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRI 275
Query: 287 NENTFAPLQKLDELDLGSNKIENLPPLIFKD------LKELSQLNLSYNP-IQKIQANQF 339
F+ + L EL I N+P LI D L +L ++ + NP + I N F
Sbjct: 276 RRGDFSNMLHLKELG-----INNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAF 330
Query: 340 DYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
L KL+SL L +S + L NL I
Sbjct: 331 FRLPKLESLMLNSNALSALYHGTIESLPNLKEI 363
Score = 63.2 bits (152), Expect = 9e-10
Identities = 50/174 (28%), Positives = 83/174 (47%), Gaps = 6/174 (3%)
Query: 203 LIIEDNHLSRISPPTFYGLNSLILLVLMNNV--LTRLPDKPLCQHMPRLHWLDLEGNHIH 260
L+++ N++++I T + +N L + NN+ +T + K MP+L + LE N +
Sbjct: 74 LLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKK----MPQLLSVYLEENKLT 129
Query: 261 NLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKE 320
L SNL L + N ++ ++ F L L L L SN+++ + F L
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
Query: 321 LSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYF 374
L L + NPI +I+ F L+ L+SL + GI ++ I L NL I F
Sbjct: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISF 243
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 105 bits (263), Expect = 1e-22
Identities = 82/273 (30%), Positives = 133/273 (48%), Gaps = 17/273 (6%)
Query: 111 LDCDETNLRAVPSVS----SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSIS 166
LD + NL +V +++ + ++ L+ N + +LP C +LQ+LY+ +N +++IS
Sbjct: 97 LDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTIS 156
Query: 167 IYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLIL 226
AF GL++L +L+L+ NR+ + F+ L LE L+I +N + RI F L +L
Sbjct: 157 PGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRS 216
Query: 227 LVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHL 286
LV+ LT +PD L + L + N + + ++ NL L + KN IN +
Sbjct: 217 LVIAGINLTEIPDNALV-GLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRI 275
Query: 287 NENTFAPLQKLDELDLGSNKIENLPPLIFKD------LKELSQLNLSYNP-IQKIQANQF 339
F+ + L EL I N+P LI D L +L ++ + NP + I N F
Sbjct: 276 RRGDFSNMLHLKELG-----INNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAF 330
Query: 340 DYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
L KL+SL L +S + L NL I
Sbjct: 331 FRLPKLESLMLNSNALSALYHGTIESLPNLKEI 363
Score = 63.2 bits (152), Expect = 9e-10
Identities = 50/174 (28%), Positives = 83/174 (47%), Gaps = 6/174 (3%)
Query: 203 LIIEDNHLSRISPPTFYGLNSLILLVLMNNV--LTRLPDKPLCQHMPRLHWLDLEGNHIH 260
L+++ N++++I T + +N L + NN+ +T + K MP+L + LE N +
Sbjct: 74 LLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKK----MPQLLSVYLEENKLT 129
Query: 261 NLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKE 320
L SNL L + N ++ ++ F L L L L SN+++ + F L
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
Query: 321 LSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYF 374
L L + NPI +I+ F L+ L+SL + GI ++ I L NL I F
Sbjct: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISF 243
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 105 bits (263), Expect = 1e-22
Identities = 82/273 (30%), Positives = 133/273 (48%), Gaps = 17/273 (6%)
Query: 111 LDCDETNLRAVPSVS----SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSIS 166
LD + NL +V +++ + ++ L+ N + +LP C +LQ+LY+ +N +++IS
Sbjct: 97 LDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTIS 156
Query: 167 IYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLIL 226
AF GL++L +L+L+ NR+ + F+ L LE L+I +N + RI F L +L
Sbjct: 157 PGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRS 216
Query: 227 LVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHL 286
LV+ LT +PD L + L + N + + ++ NL L + KN IN +
Sbjct: 217 LVIAGINLTEIPDNALV-GLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRI 275
Query: 287 NENTFAPLQKLDELDLGSNKIENLPPLIFKD------LKELSQLNLSYNP-IQKIQANQF 339
F+ + L EL I N+P LI D L +L ++ + NP + I N F
Sbjct: 276 RRGDFSNMLHLKELG-----INNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAF 330
Query: 340 DYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
L KL+SL L +S + L NL I
Sbjct: 331 FRLPKLESLMLNSNALSALYHGTIESLPNLKEI 363
Score = 63.2 bits (152), Expect = 9e-10
Identities = 50/174 (28%), Positives = 83/174 (47%), Gaps = 6/174 (3%)
Query: 203 LIIEDNHLSRISPPTFYGLNSLILLVLMNNV--LTRLPDKPLCQHMPRLHWLDLEGNHIH 260
L+++ N++++I T + +N L + NN+ +T + K MP+L + LE N +
Sbjct: 74 LLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKK----MPQLLSVYLEENKLT 129
Query: 261 NLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKE 320
L SNL L + N ++ ++ F L L L L SN+++ + F L
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
Query: 321 LSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYF 374
L L + NPI +I+ F L+ L+SL + GI ++ I L NL I F
Sbjct: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISF 243
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 105 bits (262), Expect = 2e-22
Identities = 77/237 (32%), Positives = 124/237 (52%), Gaps = 3/237 (1%)
Query: 131 MSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLK 190
+ L N++ + P F N +L+ L L++N++ I + F GL++LTKL +S N+I L
Sbjct: 100 LELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILL 159
Query: 191 PGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLH 250
+F+DL+ L+ L + DN L IS F GLNSL L L LT +P + L H+ L
Sbjct: 160 DYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEAL-SHLHGLI 218
Query: 251 WLDLEGNHIHNLRNLTFISCSNLTVL-VMRKNKINHLNENTFAPLQKLDELDLGSNKIEN 309
L L +I+ +R+ +F L VL + ++ + N L L L + +
Sbjct: 219 VLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL-NLTSLSITHCNLTA 277
Query: 310 LPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPL 366
+P L + L L LNLSYNPI I+ + L++L+ + L G +++ ++ FR L
Sbjct: 278 VPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGL 334
Score = 55.5 bits (132), Expect = 2e-07
Identities = 56/209 (26%), Positives = 81/209 (38%), Gaps = 26/209 (12%)
Query: 172 GLNSLTKLY-LSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLM 230
G+ + T+L L NRI L F LE L + +N +S + P F L +L L L
Sbjct: 68 GIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLR 127
Query: 231 NNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENT 290
+N L +P F SNLT L + +NKI L +
Sbjct: 128 SNRLKLIPLG-------------------------VFTGLSNLTKLDISENKIVILLDYM 162
Query: 291 FAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSL 350
F L L L++G N + + F L L QL L + I +L L L L
Sbjct: 163 FQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRL 222
Query: 351 EGIEISNIQQRMFRPLMNLSHIYFKKFQY 379
+ I+ I+ F+ L L + + Y
Sbjct: 223 RHLNINAIRDYSFKRLYRLKVLEISHWPY 251
Score = 54.7 bits (130), Expect = 3e-07
Identities = 40/133 (30%), Positives = 63/133 (47%), Gaps = 12/133 (9%)
Query: 84 SQYPF-EAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSN----VTAMSLQWNLI 138
S +P+ + TP CL G L NL AVP ++ + ++L +N I
Sbjct: 247 SHWPYLDTMTPNCLYG-------LNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPI 299
Query: 139 RKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLH 198
+ LQ++ L ++ + YAFRGLN L L +S N++T L+ VF +
Sbjct: 300 STIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVG 359
Query: 199 RLEWLIIEDNHLS 211
LE LI++ N L+
Sbjct: 360 NLETLILDSNPLA 372
Score = 49.7 bits (117), Expect = 1e-05
Identities = 48/199 (24%), Positives = 82/199 (41%), Gaps = 21/199 (10%)
Query: 275 VLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKI 334
+L + KN+I LN++ FA L+EL+L N + + P F +L L L L N ++ I
Sbjct: 75 LLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLI 134
Query: 335 QANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSH--------IYFKKFQYCGYAP-- 384
F L L L + +I + MF+ L NL +Y + G
Sbjct: 135 PLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLE 194
Query: 385 --HVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFG-------NIFVICMRPYI-- 433
+ C + +L +L I+ R+ ++A+ + + I PY+
Sbjct: 195 QLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDT 254
Query: 434 RSENKLYAMSIISLCCADC 452
+ N LY +++ SL C
Sbjct: 255 MTPNCLYGLNLTSLSITHC 273
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 105 bits (262), Expect = 2e-22
Identities = 82/286 (28%), Positives = 128/286 (44%), Gaps = 21/286 (7%)
Query: 82 MTSQYPFEAETPECLVGSVPVQCLCQ-------------GLELDCDETNLRAVPS-VSSN 127
MTS + EC P C+C+ +DC++ L +PS +SS+
Sbjct: 19 MTSLTESSIQNSEC-----PQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSD 73
Query: 128 VTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRIT 187
+ LQ N I K D + +L +L N T+I L LT L+L N+IT
Sbjct: 74 TQVLLLQSNNIAKTV-DELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQIT 132
Query: 188 FLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMP 247
+ +DL L+ L I N +S IS F GL +L+ L L +N L ++ D P
Sbjct: 133 EMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKL-KVIDSRWFDSTP 191
Query: 248 RLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKI 307
L L + N + + ++ F +NL LV+ + + N L L+ L NK+
Sbjct: 192 NLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKL 251
Query: 308 ENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGI 353
+P L + + L L+L+ NPI KIQ F +++LK L + +
Sbjct: 252 VKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNM 297
Score = 99.0 bits (245), Expect = 1e-20
Identities = 76/269 (28%), Positives = 131/269 (48%), Gaps = 7/269 (2%)
Query: 110 ELDCDETNLRAVPSVS----SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSI 165
ELD + N + V + +T + L+ N I ++ C ++ +LQ+LY+ +N+I++I
Sbjct: 99 ELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTI 158
Query: 166 SIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLI 225
S +AF GL +L +L+L+ N++ + F+ LE L+I +N + I F L +L
Sbjct: 159 SAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLR 218
Query: 226 LLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINH 285
LVL LT +P L + L L N + + L NL L + KN I+
Sbjct: 219 SLVLAGMYLTDIPGNALV-GLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHK 277
Query: 286 LNENTFAPLQKLDELDLGS-NKIENLPPLIFKDLKELSQLNLSYNP-IQKIQANQFDYLV 343
+ E F + +L EL + + ++ ++ +L EL++L + NP + I F +
Sbjct: 278 IQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVP 337
Query: 344 KLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
L+SL L ++ I Q+ L NL I
Sbjct: 338 ALESLMLNNNALNAIYQKTVESLPNLREI 366
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/163 (26%), Positives = 78/163 (47%), Gaps = 5/163 (3%)
Query: 207 DNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLT 266
D L+RI P+ ++ +LL+ NN+ + + Q + L LD N+ N++ +
Sbjct: 60 DLRLTRI--PSNLSSDTQVLLLQSNNIAKTVDE---LQQLFNLTELDFSQNNFTNIKEVG 114
Query: 267 FISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNL 326
+ + LT L + +N+I + + L L EL + N+I + F LK L +L+L
Sbjct: 115 LANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHL 174
Query: 327 SYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNL 369
+ N ++ I + FD L+ L + + I F+PL NL
Sbjct: 175 NSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANL 217
Score = 54.7 bits (130), Expect = 3e-07
Identities = 46/172 (26%), Positives = 81/172 (47%), Gaps = 2/172 (1%)
Query: 203 LIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNL 262
L+++ N++++ + L +L L N T + + L ++ +L L LE N I +
Sbjct: 77 LLLQSNNIAK-TVDELQQLFNLTELDFSQNNFTNIKEVGLA-NLTQLTTLHLEENQITEM 134
Query: 263 RNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELS 322
+ SNL L + N+I+ ++ + FA L+ L L L SNK++ + F L
Sbjct: 135 TDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLE 194
Query: 323 QLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYF 374
L + NP+ I F L L+SL L G+ +++I L +L + F
Sbjct: 195 ILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSF 246
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 103 bits (257), Expect = 6e-22
Identities = 82/293 (27%), Positives = 138/293 (47%), Gaps = 29/293 (9%)
Query: 104 CLCQGLELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKI 162
C C G LDC L A+P + S +++L +N + ++ P F++ +LQ++YL NN++
Sbjct: 45 CTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNEL 104
Query: 163 TSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRI-------SP 215
T++ + + L+L HN+I ++ + LE L + N+++ + P
Sbjct: 105 TAVPSLGAAS-SHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGP 163
Query: 216 P-----------------TFYGLN-SLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGN 257
P F GL+ SL+ L L N +T+LP + +PRL LDL N
Sbjct: 164 PIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAF--KLPRLTQLDLNRN 221
Query: 258 HIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKD 317
I + LTF ++L VL +++N I+ L + F L K+ L L N + +
Sbjct: 222 RIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYG 281
Query: 318 LKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLS 370
L L QL+LS N I +I + + KL L L ++ + + L +LS
Sbjct: 282 LTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLS 334
Score = 99.0 bits (245), Expect = 1e-20
Identities = 84/260 (32%), Positives = 120/260 (46%), Gaps = 36/260 (13%)
Query: 118 LRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLT 177
L A +S ++ + L N I +LP FK L +L L N+I I F+GLNSL
Sbjct: 180 LGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLE 238
Query: 178 KLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRL 237
L L N I+ L G F L ++ L +E N L ++ + YGL +L L L NN + R+
Sbjct: 239 VLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARI 298
Query: 238 PDK--PLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQ 295
K CQ +LH L L N++ L + S+L+VL + N I+H+ E F L+
Sbjct: 299 HRKGWSFCQ---KLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLR 355
Query: 296 KLDELDLG---------------------------SNKIENLPPLIFKDLKELSQLNLSY 328
L LDL NKI+++ F L+ L LNL
Sbjct: 356 SLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGG 415
Query: 329 NPIQKIQANQFDYLVKLKSL 348
N I+ + QFD VK+K+L
Sbjct: 416 NAIRSV---QFDAFVKMKNL 432
Score = 94.7 bits (234), Expect = 3e-19
Identities = 103/352 (29%), Positives = 149/352 (42%), Gaps = 51/352 (14%)
Query: 33 PCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAET 92
PC C L DCG + GD W+ + SY K++ P E
Sbjct: 40 PCAAACTCAGDSL------DCGGRGLAALPGDLPSWTRSLN---LSYNKLSEIDPAGFED 90
Query: 93 PECLVGSVPVQCLCQGLELDCDETNLRAVPSV---SSNVTAMSLQWNLIRKLPPD----- 144
L E+ + L AVPS+ SS+V ++ LQ N IR +
Sbjct: 91 LPNLQ------------EVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAY 138
Query: 145 -------------------CFKNYHDLQKLYLQNNKITSISIYAFRGLN-SLTKLYLSHN 184
CF + +++L L N+I ++ + AF GL+ SL L LS N
Sbjct: 139 LSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKN 198
Query: 185 RITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQ 244
RIT L F+ L RL L + N + I TF GLNSL +L L N +++L D
Sbjct: 199 RITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWG 257
Query: 245 HMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGS 304
+ ++H L LE N + + + + + L L + N I ++ ++ QKL EL L
Sbjct: 258 -LSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSF 316
Query: 305 NKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEIS 356
N + L +L LS L LS+N I I F L L+ L L+ EIS
Sbjct: 317 NNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEIS 368
Score = 32.7 bits (73), Expect = 1.3
Identities = 22/63 (34%), Positives = 29/63 (46%)
Query: 146 FKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLII 205
F L KL L NKI S++ AF GL L L L N I ++ F + L+ L I
Sbjct: 378 FSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHI 437
Query: 206 EDN 208
+
Sbjct: 438 SSD 440
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 102 bits (254), Expect = 1e-21
Identities = 75/254 (29%), Positives = 124/254 (48%), Gaps = 31/254 (12%)
Query: 123 SVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLS 182
++SS++ + L N + +PP FK H LQ L L+ N+I + F+GL+SL L +
Sbjct: 189 NLSSSLLVVKLNRNRMSMIPPKIFKLPH-LQFLELKRNRIKIVEGLTFQGLDSLRSLKMQ 247
Query: 183 HNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRL-PDKP 241
N I+ LK G F L+ +E L +E N+L+R++ YGL L L + N + R+ PD
Sbjct: 248 RNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPD-- 305
Query: 242 LCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELD 301
+ C L+ L + N++ L+E+ F L L+ L+
Sbjct: 306 ------------------------AWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLN 341
Query: 302 LGSNKIENLPPLIFKDLKELSQLNLSYNPIQ---KIQANQFDYLVKLKSLSLEGIEISNI 358
LG N++ ++ +F+ L L L+L N I + + F L L L L+G +I +I
Sbjct: 342 LGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSI 401
Query: 359 QQRMFRPLMNLSHI 372
++ F L +L H+
Sbjct: 402 TKKAFIGLESLEHL 415
Score = 91.7 bits (226), Expect = 2e-18
Identities = 75/269 (27%), Positives = 127/269 (47%), Gaps = 50/269 (18%)
Query: 125 SSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHN 184
+SN+T +SL N+I ++ + Y L+ L L +N I+ I +F + L L LS+N
Sbjct: 119 TSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNN 177
Query: 185 RITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQ 244
RIT L+ G F++L +SL+++ L N ++ +P K
Sbjct: 178 RITTLEAGCFDNLS-----------------------SSLLVVKLNRNRMSMIPPKIF-- 212
Query: 245 HMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDL-- 302
+P L +L+L+ N I + LTF +L L M++N I+ L + F L ++EL+L
Sbjct: 213 KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEH 272
Query: 303 ----------------------GSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFD 340
N IE + P ++ + LS+L+LSYN + ++ + F
Sbjct: 273 NNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFV 332
Query: 341 YLVKLKSLSLEGIEISNIQQRMFRPLMNL 369
L L+ L+L +++I +FR L NL
Sbjct: 333 GLSLLERLNLGDNRVTHIADGVFRFLSNL 361
Score = 66.6 bits (161), Expect = 8e-11
Identities = 54/198 (27%), Positives = 91/198 (45%), Gaps = 24/198 (12%)
Query: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
+N+ + L+ N + ++ LQ+LY+ N I IS A+ L++L LS+N+
Sbjct: 263 NNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQ 322
Query: 186 ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQH 245
+T L F L LE L + DN ++ I+ F L++L L L NN
Sbjct: 323 LTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNN------------- 369
Query: 246 MPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
+ W + + F ++LT L+++ N+I + + F L+ L+ LDL +N
Sbjct: 370 --EISWAIEDASE-------AFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNN 420
Query: 306 KIENLPPLIFKD--LKEL 321
I ++ F LKEL
Sbjct: 421 AIMSIQENAFSQTHLKEL 438
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.141 0.443
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,456,321
Number of Sequences: 37866
Number of extensions: 1248682
Number of successful extensions: 7191
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 274
Number of HSP's successfully gapped in prelim test: 407
Number of HSP's that attempted gapping in prelim test: 3900
Number of HSP's gapped (non-prelim): 1880
length of query: 757
length of database: 18,247,518
effective HSP length: 110
effective length of query: 647
effective length of database: 14,082,258
effective search space: 9111220926
effective search space used: 9111220926
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.