BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|83320070 gasdermin D [Homo sapiens] (484 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|83320070 gasdermin D [Homo sapiens] 968 0.0 gi|150456463 gasdermin 1 [Homo sapiens] 196 4e-50 gi|13899221 melanoma-derived leucine zipper, extra-nuclear facto... 174 1e-43 gi|109689703 gasdermin-like isoform 1 [Homo sapiens] 88 2e-17 gi|109689711 gasdermin-like isoform 2 [Homo sapiens] 85 2e-16 gi|4758154 deafness, autosomal dominant 5 protein isoform a [Hom... 58 2e-08 gi|188536092 deafness, autosomal dominant 5 protein isoform a [H... 58 2e-08 gi|111607457 deafness, autosomal recessive 59 [Homo sapiens] 50 6e-06 gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 34 0.26 gi|92091575 coiled-coil domain containing 57 [Homo sapiens] 33 0.76 gi|150421681 ATPase, class VI, type 11A isoform b [Homo sapiens] 32 0.99 gi|70780384 protease inhibitor 16 precursor [Homo sapiens] 32 0.99 gi|229892328 IQ motif containing C isoform 1 [Homo sapiens] 32 1.3 gi|238908495 similar to pleckstrin homology domain protein (5V32... 32 1.7 gi|239753475 PREDICTED: hypothetical protein [Homo sapiens] 32 1.7 gi|239748044 PREDICTED: hypothetical protein XP_002346500 [Homo ... 32 1.7 gi|239741935 PREDICTED: hypothetical protein XP_002342357 [Homo ... 32 1.7 gi|75677365 dynein heavy chain domain 3 [Homo sapiens] 32 1.7 gi|7705638 bolA-like 1 [Homo sapiens] 31 2.2 gi|109715835 HEAT repeat containing 6 [Homo sapiens] 30 3.8 gi|34452725 polypeptide N-acetylgalactosaminyltransferase 4 [Hom... 30 4.9 gi|73695473 roquin [Homo sapiens] 30 4.9 gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 30 6.4 gi|5901944 elastin microfibril interfacer 1 [Homo sapiens] 30 6.4 gi|66392157 RGD motif, leucine rich repeats, tropomodulin domain... 30 6.4 gi|187608767 E74-like factor 4 [Homo sapiens] 29 8.4 gi|4503555 E74-like factor 4 [Homo sapiens] 29 8.4 gi|47086907 lysophosphatidylcholine acyltransferase 2 [Homo sapi... 29 8.4 gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] 29 8.4 gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] 29 8.4 >gi|83320070 gasdermin D [Homo sapiens] Length = 484 Score = 968 bits (2503), Expect = 0.0 Identities = 484/484 (100%), Positives = 484/484 (100%) Query: 1 MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLS 60 MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLS Sbjct: 1 MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLS 60 Query: 61 IKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNV 120 IKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNV Sbjct: 61 IKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNV 120 Query: 121 YSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREG 180 YSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREG Sbjct: 121 YSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREG 180 Query: 181 SGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTF 240 SGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTF Sbjct: 181 SGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTF 240 Query: 241 QPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKE 300 QPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKE Sbjct: 241 QPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKE 300 Query: 301 LELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSS 360 LELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSS Sbjct: 301 LELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSS 360 Query: 361 GMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERST 420 GMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERST Sbjct: 361 GMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERST 420 Query: 421 MSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLS 480 MSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLS Sbjct: 421 MSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLS 480 Query: 481 QEPH 484 QEPH Sbjct: 481 QEPH 484 >gi|150456463 gasdermin 1 [Homo sapiens] Length = 445 Score = 196 bits (498), Expect = 4e-50 Identities = 156/480 (32%), Positives = 239/480 (49%), Gaps = 43/480 (8%) Query: 5 FERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDI 64 FE V R + ++L+ G+ P+ SL F P+CLV+RK S+ FW RY + ++ D+ Sbjct: 4 FENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTLLDV 63 Query: 65 LEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLS 124 LEP ++ D +F F + +D +++G V++ P K+ G A +S +S ++ V +LS Sbjct: 64 LEPGSSPSDPTDTGNFGFKNMLDTRVEGDVDV--PKTVKVKGTAGLSQNS--TLEVQTLS 119 Query: 125 VDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRF 184 V P +T + ER L +H L++++ +G+N+YVV EV++T +EV + R K E F Sbjct: 120 VAPKALET-VQERKL-AADHPFLKEMQDQGENLYVVMEVVETVQEVTLERAGKAEAC--F 175 Query: 185 SLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVI--DSDLDVLLFPDKKQRTFQP 242 SLP L QG ++ K+ VTIP G LAFRV QL++ + D+ + +TF P Sbjct: 176 SLPFFAPL--GLQGSINHKEAVTIPKGCVLAFRVRQLMVKGKDEWDIPHICNDNMQTFPP 233 Query: 243 PATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKELE 302 G K + Q G E F+ L+ EV+ ++++E Sbjct: 234 ---GEKSGEEKVILIQASD------------------VGDVHEGFRTLKEEVQRETQQVE 272 Query: 303 LLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGM 362 L R LL L +L + L+ LE ALE LD LE L + Sbjct: 273 KLSRVGQSSLLSSLSKLLGKKKELQDLELALEGA--------LDKGHEVTLEALP-KDVL 323 Query: 363 LVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMS 422 L E ++Y +GALT LSE Q KLL +++E + L L+LV S +EQ+ + Sbjct: 324 LSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFP 383 Query: 423 LPPGLLGNSWGEGAP-AWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQ 481 L P LL + E L+ GLE+ P W+P R+CALYA L+LL L++ Sbjct: 384 LQPELLSSLGDEELTLTEALVGLSGLEVQRSGPQYMWDPDTLPRLCALYAGLSLLQQLTK 443 >gi|13899221 melanoma-derived leucine zipper, extra-nuclear factor [Homo sapiens] Length = 508 Score = 174 bits (442), Expect = 1e-43 Identities = 157/520 (30%), Positives = 251/520 (48%), Gaps = 52/520 (10%) Query: 1 MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSS-SWFWKPR-YKCVN 58 M S ER+ + +V+E+ + PV L S+T + + ++ +K S S FW+ Y V Sbjct: 1 MPSMLERISKNLVKEIG-SKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVE 59 Query: 59 LSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSM 118 S+ DILEP ++ + FHF D M + + + + + ++G A+V S Sbjct: 60 FSLNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHGCSLEF 119 Query: 119 NVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKR 178 + ++ PN +R L PE L++ R RGDN+YVVTE ++ + + Sbjct: 120 QIVTIP-SPNLED--FQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSV 176 Query: 179 EGSGRFSLPGATCLQGEGQGHLSQ--KKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKK 236 G+ +L T +G+GQG + KK +T+ G +A++ QLVI + +L+ D + Sbjct: 177 NILGKIAL-WITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVI-KEKAILISDDDE 234 Query: 237 QRTFQPP-----ATGHKRSTSEGAWPQLPSGLSMMRCLHN-----------------FLT 274 QRTFQ G+ + SEG LPS ++ L N FL+ Sbjct: 235 QRTFQDEYEISEMVGYCAARSEGL---LPSFHTISPTLFNASSNDMKLKPELFLTQQFLS 291 Query: 275 DGVPA------------EGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRD 322 +P E F ++F+ L+ EV K L L +++ ++ + +LRD Sbjct: 292 GHLPKYEQVHILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRD 351 Query: 323 QLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLS 382 + AL+ L LE S LDGP GA+L+ L S P++YLL A+ +LS Sbjct: 352 RGALQDLMNMLELDSS----GHLDGPGGAILKKLQQDSNHAWFNPKDPILYLLEAIMVLS 407 Query: 383 ETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEG-APAWVL 441 + QH LLA ++E + LL ELV S+LE + + +L P LL EG A + L Sbjct: 408 DFQHDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGL 467 Query: 442 LDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQ 481 L+ECGL + D P W+ +A+ + ALY +L+LL L++ Sbjct: 468 LEECGLRMELDNPRSTWDVEAKMPLSALYGTLSLLQQLAE 507 >gi|109689703 gasdermin-like isoform 1 [Homo sapiens] Length = 403 Score = 88.2 bits (217), Expect = 2e-17 Identities = 122/494 (24%), Positives = 207/494 (41%), Gaps = 107/494 (21%) Query: 1 MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLS 60 M S FE + R VV+E+D GG+ I V SL + F+ + LV K + F+ R+ L+ Sbjct: 1 MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRT---FFGCRHYTTGLT 57 Query: 61 IKDILEPDAAE--PDVQRG-----RSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDS 113 + DIL+ D + ++ G F D +D G + + P + I+G Sbjct: 58 LMDILDTDGDKWLDELDSGLQGQKAEFQILDNVDS--TGELIVRLPKEITISGSFQGFHH 115 Query: 114 SSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVT 173 ++ +S + L R L++ + + +R +N+Y+VTE L+T KE + Sbjct: 116 QKIKISENRIS---QQYLATLENRKLKRELPFSFRSINTR-ENLYLVTETLETVKEETLK 171 Query: 174 RTHKREGSGRFSLPGATCLQGEGQGHLSQK----KTVTIPSGSTLAFRVAQLVIDSDLDV 229 + + + S QGHLS K + VTIP L++RV QLV Sbjct: 172 SDRQYKFWSQIS-----------QGHLSYKHKGQREVTIPPNRVLSYRVKQLV------- 213 Query: 230 LLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQG 289 FP+K + +GA L L +ED + Sbjct: 214 --FPNK------------ETMKKDGASSCLGKSLG-------------------SEDSRN 240 Query: 290 LRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPA 349 ++ ++E + L+ L E + +L L L + + LE+ + + G + ++ P Sbjct: 241 MKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELH-MEDPD 299 Query: 350 GAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLL 409 +L L ++G+LV A ++ L AL LSE Q + +AEALE TL + V S++ Sbjct: 300 KPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQ-QFVAEALEKGTLPLLKDQVKSVM 358 Query: 410 EQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCAL 469 EQ+ W EL P + ++P+A+ +CAL Sbjct: 359 EQN--WD-------------------------------ELASSPPDMDYDPEAR-ILCAL 384 Query: 470 YASLALLSGLSQEP 483 Y +++L L++ P Sbjct: 385 YVVVSILLELAEGP 398 >gi|109689711 gasdermin-like isoform 2 [Homo sapiens] Length = 394 Score = 84.7 bits (208), Expect = 2e-16 Identities = 120/494 (24%), Positives = 206/494 (41%), Gaps = 116/494 (23%) Query: 1 MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLS 60 M S FE + R VV+E+D GG+ I V SL + F+ + LV K + F+ R+ L+ Sbjct: 1 MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRT---FFGCRHYTTGLT 57 Query: 61 IKDILEPDAAE--PDVQRG-----RSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDS 113 + DIL+ D + ++ G F D +D G + + P + I+G Sbjct: 58 LMDILDTDGDKWLDELDSGLQGQKAEFQILDNVDS--TGELIVRLPKEITISGSFQGFHH 115 Query: 114 SSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVT 173 ++ +S + L R L++ + + +R +N+Y+VTE L+T KE + Sbjct: 116 QKIKISENRIS---QQYLATLENRKLKRELPFSFRSINTR-ENLYLVTETLETVKEETLK 171 Query: 174 RTHKREGSGRFSLPGATCLQGEGQGHLSQK----KTVTIPSGSTLAFRVAQLVIDSDLDV 229 + + + S QGHLS K + VTIP L++RV QLV Sbjct: 172 SDRQYKFWSQIS-----------QGHLSYKHKGQREVTIPPNRVLSYRVKQLV------- 213 Query: 230 LLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQG 289 FP+K+ +M + L +ED + Sbjct: 214 --FPNKE---------------------------TMRKSLG-------------SEDSRN 231 Query: 290 LRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPA 349 ++ ++E + L+ L E + +L L L + + LE+ + + G + ++ P Sbjct: 232 MKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELH-MEDPD 290 Query: 350 GAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLL 409 +L L ++G+LV A ++ L AL LSE Q + +AEALE TL + V S++ Sbjct: 291 KPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQ-QFVAEALEKGTLPLLKDQVKSVM 349 Query: 410 EQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCAL 469 EQ+ W EL P + ++P+A+ +CAL Sbjct: 350 EQN--WD-------------------------------ELASSPPDMDYDPEAR-ILCAL 375 Query: 470 YASLALLSGLSQEP 483 Y +++L L++ P Sbjct: 376 YVVVSILLELAEGP 389 >gi|4758154 deafness, autosomal dominant 5 protein isoform a [Homo sapiens] Length = 496 Score = 57.8 bits (138), Expect = 2e-08 Identities = 84/352 (23%), Positives = 150/352 (42%), Gaps = 55/352 (15%) Query: 5 FERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFW-KPRYKCVNLSIKD 63 F + R ++E+D G+ I V++L S Q LV +K W W +P+Y+ ++L++ D Sbjct: 2 FAKATRNFLREVDADGDLIAVSNLNDSDKLQLLSLVTKK-KRFWCWQRPKYQFLSLTLGD 60 Query: 64 ILEPDAAEPDVQRGRSFHFYDA-MDGQIQGSVELAAPGQAKI-AGGAAVSDSSSTSMNVY 121 +L D V F Y+ + G++E A G+ K+ GG++ +S S+ + Sbjct: 61 VLIEDQFPSPVVVESDFVKYEGKFANHVSGTLETAL-GKVKLNLGGSSRVESQSSFGTLR 119 Query: 122 SLSVDPNTWQTLLHER-----HLRQPEHKVLQQ-LRSRGDNVYVVTEVLQTQKEVEVTRT 175 VD Q L+ + +LR P VLQQ L R + + V+T+ + T ++ ++ Sbjct: 120 KQEVD---LQQLIRDSAERTINLRNP---VLQQVLEGRNEVLCVLTQKITTMQKCVISEH 173 Query: 176 HKREG--SGRFSLPGATC-LQGEGQGHLSQKKTVT--IPSGSTLAFRVAQLVIDSD---- 226 + E G + T + G++++ V IP+ +T+A+ V +L + D Sbjct: 174 MQVEEKCGGIVGIQTKTVQVSATEDGNVTKDSNVVLEIPAATTIAYGVIELYVKLDGQFE 233 Query: 227 ---------------------LDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSG-LS 264 LD L+F ++ P H S+ +G L L Sbjct: 234 FCLLRGKQGGFENKKRIDSVYLDPLVF--REFAFIDMPDAAHGISSQDGPLSVLKQATLL 291 Query: 265 MMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGL 316 + R H F P + A ++ FQ + EL ++ +C L+ GL Sbjct: 292 LERNFHPFAELPEPQQTALSDIFQAV-----LFDDELLMVLEPVCDDLVSGL 338 >gi|188536092 deafness, autosomal dominant 5 protein isoform a [Homo sapiens] Length = 496 Score = 57.8 bits (138), Expect = 2e-08 Identities = 84/352 (23%), Positives = 150/352 (42%), Gaps = 55/352 (15%) Query: 5 FERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFW-KPRYKCVNLSIKD 63 F + R ++E+D G+ I V++L S Q LV +K W W +P+Y+ ++L++ D Sbjct: 2 FAKATRNFLREVDADGDLIAVSNLNDSDKLQLLSLVTKK-KRFWCWQRPKYQFLSLTLGD 60 Query: 64 ILEPDAAEPDVQRGRSFHFYDA-MDGQIQGSVELAAPGQAKI-AGGAAVSDSSSTSMNVY 121 +L D V F Y+ + G++E A G+ K+ GG++ +S S+ + Sbjct: 61 VLIEDQFPSPVVVESDFVKYEGKFANHVSGTLETAL-GKVKLNLGGSSRVESQSSFGTLR 119 Query: 122 SLSVDPNTWQTLLHER-----HLRQPEHKVLQQ-LRSRGDNVYVVTEVLQTQKEVEVTRT 175 VD Q L+ + +LR P VLQQ L R + + V+T+ + T ++ ++ Sbjct: 120 KQEVD---LQQLIRDSAERTINLRNP---VLQQVLEGRNEVLCVLTQKITTMQKCVISEH 173 Query: 176 HKREG--SGRFSLPGATC-LQGEGQGHLSQKKTVT--IPSGSTLAFRVAQLVIDSD---- 226 + E G + T + G++++ V IP+ +T+A+ V +L + D Sbjct: 174 MQVEEKCGGIVGIQTKTVQVSATEDGNVTKDSNVVLEIPAATTIAYGVIELYVKLDGQFE 233 Query: 227 ---------------------LDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSG-LS 264 LD L+F ++ P H S+ +G L L Sbjct: 234 FCLLRGKQGGFENKKRIDSVYLDPLVF--REFAFIDMPDAAHGISSQDGPLSVLKQATLL 291 Query: 265 MMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGL 316 + R H F P + A ++ FQ + EL ++ +C L+ GL Sbjct: 292 LERNFHPFAELPEPQQTALSDIFQAV-----LFDDELLMVLEPVCDDLVSGL 338 >gi|111607457 deafness, autosomal recessive 59 [Homo sapiens] Length = 352 Score = 49.7 bits (117), Expect = 6e-06 Identities = 60/232 (25%), Positives = 104/232 (44%), Gaps = 24/232 (10%) Query: 5 FERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVN--LSIK 62 F + V+++ GG +PV SL + +QP LVV+K F PRYK + ++K Sbjct: 2 FAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLF--PRYKFTSTPFTLK 59 Query: 63 DILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYS 122 DIL D ++ G S Y ++ + + V L I ++ + S S+ V + Sbjct: 60 DILLGDR---EISAGIS--SYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKA 114 Query: 123 ----LSVDPNTWQTLLHERHLRQP--EHKVLQQLR-SRGDNVYVVTEVLQTQKEVEVT-R 174 ++ TLL E R+ +H +++Q R SR + VV E ++T ++ ++ Sbjct: 115 SFGIVTKHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVH 174 Query: 175 THKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSD 226 R + RF + Q + K + P+ +T+AF V +L I D Sbjct: 175 AGIRGEAMRFHFM-------DEQNPKGRDKAIVFPAHTTIAFSVFELFIYLD 219 >gi|18250298 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites [Homo sapiens] Length = 488 Score = 34.3 bits (77), Expect = 0.26 Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 6/98 (6%) Query: 109 AVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQK 168 A+ S +M + L+ + T + L HER +R L + S G+ VY+VTE+++ Sbjct: 256 AIKVIKSANMKLTDLAKEIQTLKGLRHERLIR------LHAVCSGGEPVYIVTELMRKGN 309 Query: 169 EVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTV 206 T + L G C EG +L +++ V Sbjct: 310 LQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVV 347 >gi|92091575 coiled-coil domain containing 57 [Homo sapiens] Length = 915 Score = 32.7 bits (73), Expect = 0.76 Identities = 44/158 (27%), Positives = 69/158 (43%), Gaps = 27/158 (17%) Query: 51 KPRYKCVNLSIKDILEP-------DAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAK 103 K ++K + ++D+L+P ++P V+ A GQ GSV QA Sbjct: 590 KHKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSV------QAG 643 Query: 104 IAGGAAVSDSSSTSMNVYSLSVDP---NTWQTLLHERHLRQP-EHKVLQ-QLRSRGDNVY 158 AGG+ + S+ + + L N T L ++ LR+P E LQ +L D V+ Sbjct: 644 QAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVH 703 Query: 159 VVTEVLQTQKEVEVTRTHKR-------EGSGRFSLPGA 189 + EVL+ +K+V H R E SGR P + Sbjct: 704 L--EVLELRKQVAELGKHLRIAQHGGAEPSGRKQPPAS 739 >gi|150421681 ATPase, class VI, type 11A isoform b [Homo sapiens] Length = 1191 Score = 32.3 bits (72), Expect = 0.99 Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 6/47 (12%) Query: 3 SAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWF 49 +A ERV Q D EF P+ SLQ S G+Q C PS++W+ Sbjct: 1103 TATERVQNGCAQPRDRDSEFTPLASLQ-SPGYQSTC-----PSAAWY 1143 >gi|70780384 protease inhibitor 16 precursor [Homo sapiens] Length = 463 Score = 32.3 bits (72), Expect = 0.99 Identities = 43/160 (26%), Positives = 69/160 (43%), Gaps = 27/160 (16%) Query: 119 NVYSLSVDPNTWQTLLHER-----------HLRQPEHKVLQQLRSRGDNVYVVTEVLQTQ 167 N+Y V P T +LH R + RQ ++ RG+N++ +T+ Sbjct: 41 NLYRAQVSP-TASDMLHMRWDEELAAFAKAYARQCVWGHNKERGRRGENLFAITDEGMDV 99 Query: 168 KEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQ---KKTVTIPSGSTLAFRVAQLVID 224 H+RE ++L ATC G+ GH +Q KT I GS ++ Q V + Sbjct: 100 PLAMEEWHHERE---HYNLSAATCSPGQMCGHYTQVVWAKTERIGCGSHFCEKL-QGVEE 155 Query: 225 SDLDVLLFPDKKQRTFQPPA-TGHKRSTSEGA-WPQLPSG 262 +++++L+ ++PP KR EG Q PSG Sbjct: 156 TNIELLVC------NYEPPGNVKGKRPYQEGTPCSQCPSG 189 >gi|229892328 IQ motif containing C isoform 1 [Homo sapiens] Length = 546 Score = 32.0 bits (71), Expect = 1.3 Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 16/80 (20%) Query: 227 LDVLLFPDKKQRTFQP----PATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGA 282 L++ P++ + ++ P PA H T P +G S+ C+ FL Sbjct: 54 LEIPAVPNRAEESWDPRTPCPARPHSHHTLA---PDQGNGKSLKACVRGFLV-------- 102 Query: 283 FTEDFQGLRAEVETISKELE 302 FQ LRAE E I +E+E Sbjct: 103 -RRQFQSLRAEYEAIVREVE 121 >gi|238908495 similar to pleckstrin homology domain protein (5V327) [Homo sapiens] Length = 506 Score = 31.6 bits (70), Expect = 1.7 Identities = 43/150 (28%), Positives = 61/150 (40%), Gaps = 18/150 (12%) Query: 283 FTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPV 342 F E Q LR E E I +ELEL R C L+GV +++ LR L E+L+Q + Sbjct: 201 FEEVVQELRMEQEQIKRELELTAR--C------LKGVEQEKKELRHLTESLQQ-----TL 247 Query: 343 EPLDGPAGAVLECLVLSSGML-----VPELAIPVVYLLGALTMLSETQHKLLAEALESQT 397 E L LE L + L E P L L + E +LL E L ++ Sbjct: 248 EELSIEKKKTLEMLEENENHLQTLANQSEQPPPSGGLHSNLRQIEEKMQQLLEEKLLAEK 307 Query: 398 LLGPLELVGSLLEQSAPWQERSTMSLPPGL 427 + E LE+ + + +L L Sbjct: 308 RMKENEERSRALEEEREFYSSQSQALQNSL 337 >gi|239753475 PREDICTED: hypothetical protein [Homo sapiens] Length = 721 Score = 31.6 bits (70), Expect = 1.7 Identities = 18/63 (28%), Positives = 30/63 (47%), Gaps = 2/63 (3%) Query: 66 EPDAAEPDVQRGRSFHFYDAMDGQIQGSVE--LAAPGQAKIAGGAAVSDSSSTSMNVYSL 123 EP+ + P + +F FYD Q PG +K++G V+ ++ST + + Sbjct: 527 EPNGSTPSSRALPAFGFYDKSQRQATSPTGGYRRGPGLSKVSGAQDVTRATSTPSRTFDV 586 Query: 124 SVD 126 SVD Sbjct: 587 SVD 589 >gi|239748044 PREDICTED: hypothetical protein XP_002346500 [Homo sapiens] Length = 721 Score = 31.6 bits (70), Expect = 1.7 Identities = 18/63 (28%), Positives = 30/63 (47%), Gaps = 2/63 (3%) Query: 66 EPDAAEPDVQRGRSFHFYDAMDGQIQGSVE--LAAPGQAKIAGGAAVSDSSSTSMNVYSL 123 EP+ + P + +F FYD Q PG +K++G V+ ++ST + + Sbjct: 527 EPNGSTPSSRALPAFGFYDKSQRQATSPTGGYRRGPGLSKVSGAQDVTRATSTPSRTFDV 586 Query: 124 SVD 126 SVD Sbjct: 587 SVD 589 >gi|239741935 PREDICTED: hypothetical protein XP_002342357 [Homo sapiens] Length = 721 Score = 31.6 bits (70), Expect = 1.7 Identities = 18/63 (28%), Positives = 30/63 (47%), Gaps = 2/63 (3%) Query: 66 EPDAAEPDVQRGRSFHFYDAMDGQIQGSVE--LAAPGQAKIAGGAAVSDSSSTSMNVYSL 123 EP+ + P + +F FYD Q PG +K++G V+ ++ST + + Sbjct: 527 EPNGSTPSSRALPAFGFYDKSQRQATSPTGGYRRGPGLSKVSGAQDVTRATSTPSRTFDV 586 Query: 124 SVD 126 SVD Sbjct: 587 SVD 589 >gi|75677365 dynein heavy chain domain 3 [Homo sapiens] Length = 4427 Score = 31.6 bits (70), Expect = 1.7 Identities = 16/55 (29%), Positives = 30/55 (54%) Query: 292 AEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLD 346 AE + E+ + D+EL Q L + R + + +E +E G++LGP+E ++ Sbjct: 225 AEAMNMKPEMVIKDKELVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIE 279 >gi|7705638 bolA-like 1 [Homo sapiens] Length = 137 Score = 31.2 bits (69), Expect = 2.2 Identities = 32/110 (29%), Positives = 44/110 (40%), Gaps = 10/110 (9%) Query: 338 SLGPVEPL------DGPAGAVLECLVLSSGMLVP---ELAIPVVYLLGALTMLSETQHKL 388 ++GPVE + + VLE S G VP E V + LS Q Sbjct: 28 AIGPVEAAIRTKLEEALSPEVLELRNESGGHAVPPGSETHFRVAVVSSRFEGLSPLQRHR 87 Query: 389 LAEALESQTLLGPLELVGSLLEQSAPWQERSTM-SLPPGLLGNSWGEGAP 437 L A ++ L GP+ + A W+E S + + PP L GN G P Sbjct: 88 LVHAALAEELGGPVHALAIQARTPAQWRENSQLDTSPPCLGGNKKTLGTP 137 >gi|109715835 HEAT repeat containing 6 [Homo sapiens] Length = 1181 Score = 30.4 bits (67), Expect = 3.8 Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 7/81 (8%) Query: 385 QHKLLAEALESQTLLG-------PLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAP 437 +HK + + S TLLG PL V LL+Q ++ S P L W + AP Sbjct: 572 RHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLGNSNSATPHLSPPDWWKKAP 631 Query: 438 AWVLLDECGLELGEDTPHVCW 458 A L+E + + + CW Sbjct: 632 AGPSLEETSVSSPKGSSEPCW 652 >gi|34452725 polypeptide N-acetylgalactosaminyltransferase 4 [Homo sapiens] Length = 578 Score = 30.0 bits (66), Expect = 4.9 Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 8/74 (10%) Query: 130 WQTLLHERH--LRQPEHKVLQQL---RSRGDNVYVVTEV---LQTQKEVEVTRTHKREGS 181 W TLL H L +L+++ D VY+ T++ + V + RT+KREG Sbjct: 148 WSTLLRTIHSVLETSPAVLLKEIILVDDLSDRVYLKTQLETYISNLDRVRLIRTNKREGL 207 Query: 182 GRFSLPGATCLQGE 195 R L GAT G+ Sbjct: 208 VRARLIGATFATGD 221 >gi|73695473 roquin [Homo sapiens] Length = 1133 Score = 30.0 bits (66), Expect = 4.9 Identities = 18/54 (33%), Positives = 29/54 (53%) Query: 277 VPAEGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALE 330 +P++G F+E + +EV + K L +RE +L L+ L + Q LR LE Sbjct: 934 IPSQGHFSERERISMSEVASHGKPLPSAEREQLRLELQQLNHQISQQTQLRGLE 987 >gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapiens] Length = 1341 Score = 29.6 bits (65), Expect = 6.4 Identities = 28/94 (29%), Positives = 47/94 (50%), Gaps = 12/94 (12%) Query: 342 VEPLDGPAGAVLECL------VLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALES 395 +EP++GPA VL L + +LV + + +V L L+ S+T+ + AE + Sbjct: 438 IEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPE 497 Query: 396 QTLLGPLELVGSLLEQSA-----PWQERSTMSLP 424 +++L PL +L + SA P +RS LP Sbjct: 498 ESVL-PLVQKSTLADYSAQKDLEPESDRSAQPLP 530 >gi|5901944 elastin microfibril interfacer 1 [Homo sapiens] Length = 1016 Score = 29.6 bits (65), Expect = 6.4 Identities = 51/197 (25%), Positives = 77/197 (39%), Gaps = 39/197 (19%) Query: 295 ETISKELELLDRELCQLLLEGLEGVLR----DQLALRALEEALEQ---------GQSLGP 341 E + ++LE +E C + L GL+G R D+ LRA+E+ L G ++G Sbjct: 288 EELLRQLEQRLQESCSVCLAGLDGFRRQQQEDRERLRAMEKLLASVEERQRHLAGLAVGR 347 Query: 342 VEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGP 401 P EC G + EL + + G++T+LS + L A G Sbjct: 348 RPP--------QECCSPELGRRLAELERRLDVVAGSVTVLSGRRGTELGGAAGQG---GH 396 Query: 402 LELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQ 461 SL + + ++R +L P GAP GL W P Sbjct: 397 PPGYTSLASRLSRLEDRFNSTLGPSEEQEESWPGAPG-------GLS--------HWLPA 441 Query: 462 AQGRMCALYASLALLSG 478 A+GR+ L LA +SG Sbjct: 442 ARGRLEQLGGLLANVSG 458 >gi|66392157 RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing [Homo sapiens] Length = 1435 Score = 29.6 bits (65), Expect = 6.4 Identities = 21/95 (22%), Positives = 44/95 (46%), Gaps = 7/95 (7%) Query: 185 SLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVID-SDLDVLLFPDKKQRTFQPP 243 +L G + + + L+Q+ TVT+P +++ +L+ L FP++K+ + Sbjct: 881 ALAGLSAARDQLVESLAQQATVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKE-- 938 Query: 244 ATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVP 278 K + WP+L GL ++ +H+ + P Sbjct: 939 ----KDDSPPQKWPELSHGLHLVPFIHSAAEEAEP 969 >gi|187608767 E74-like factor 4 [Homo sapiens] Length = 663 Score = 29.3 bits (64), Expect = 8.4 Identities = 40/125 (32%), Positives = 48/125 (38%), Gaps = 14/125 (11%) Query: 311 LLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIP 370 L+L GL +L A R A GP P P G V+ + +SG A P Sbjct: 481 LILSGLPQLLAG--ANRPTNPAPPTVTGAGPAGPSSQPPGTVIAAFIRTSG----TTAAP 534 Query: 371 VVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSA-----PWQERSTMSLPP 425 V G L S Q + +E LL P E + LL A P Q S S P Sbjct: 535 RV-KEGPLRSSSYVQGMVTGAPMEG--LLVPEETLRELLRDQAHLQPLPTQVVSRGSHNP 591 Query: 426 GLLGN 430 LLGN Sbjct: 592 SLLGN 596 >gi|4503555 E74-like factor 4 [Homo sapiens] Length = 663 Score = 29.3 bits (64), Expect = 8.4 Identities = 40/125 (32%), Positives = 48/125 (38%), Gaps = 14/125 (11%) Query: 311 LLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIP 370 L+L GL +L A R A GP P P G V+ + +SG A P Sbjct: 481 LILSGLPQLLAG--ANRPTNPAPPTVTGAGPAGPSSQPPGTVIAAFIRTSG----TTAAP 534 Query: 371 VVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSA-----PWQERSTMSLPP 425 V G L S Q + +E LL P E + LL A P Q S S P Sbjct: 535 RV-KEGPLRSSSYVQGMVTGAPMEG--LLVPEETLRELLRDQAHLQPLPTQVVSRGSHNP 591 Query: 426 GLLGN 430 LLGN Sbjct: 592 SLLGN 596 >gi|47086907 lysophosphatidylcholine acyltransferase 2 [Homo sapiens] Length = 544 Score = 29.3 bits (64), Expect = 8.4 Identities = 30/101 (29%), Positives = 42/101 (41%), Gaps = 16/101 (15%) Query: 188 GATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGH 247 G C+ +S+ + +P L R Q V+ S +D PD ++ T Sbjct: 152 GIACVVAGLPSMVSRNENAQVPLIGRL-LRAVQPVLVSRVD----PDSRKNTINEII--- 203 Query: 248 KRSTSEGAWPQL---PSGLSMMR-CLHNF----LTDGVPAE 280 KR+TS G WPQ+ P G R CL F GVP + Sbjct: 204 KRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQ 244 >gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] Length = 1113 Score = 29.3 bits (64), Expect = 8.4 Identities = 32/128 (25%), Positives = 55/128 (42%), Gaps = 10/128 (7%) Query: 85 AMDGQIQGSVELAAPGQAKIAGGAAVSDS--SSTSMNVYSLSVDPNTWQTLLHERHLRQP 142 ++ +Q ++PG + G+ V+ S SSTS + L DP E+ + Sbjct: 425 SLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDP-------FEQLDSEL 477 Query: 143 EHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQ 202 + KV + L G + + + T E EV +T K EG GR + + LS Sbjct: 478 QSKV-EFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSP 536 Query: 203 KKTVTIPS 210 + +++ PS Sbjct: 537 RSSLSSPS 544 >gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] Length = 1118 Score = 29.3 bits (64), Expect = 8.4 Identities = 32/128 (25%), Positives = 55/128 (42%), Gaps = 10/128 (7%) Query: 85 AMDGQIQGSVELAAPGQAKIAGGAAVSDS--SSTSMNVYSLSVDPNTWQTLLHERHLRQP 142 ++ +Q ++PG + G+ V+ S SSTS + L DP E+ + Sbjct: 425 SLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDP-------FEQLDSEL 477 Query: 143 EHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQ 202 + KV + L G + + + T E EV +T K EG GR + + LS Sbjct: 478 QSKV-EFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSP 536 Query: 203 KKTVTIPS 210 + +++ PS Sbjct: 537 RSSLSSPS 544 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.133 0.396 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,749,170 Number of Sequences: 37866 Number of extensions: 937539 Number of successful extensions: 2685 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 10 Number of HSP's successfully gapped in prelim test: 25 Number of HSP's that attempted gapping in prelim test: 2653 Number of HSP's gapped (non-prelim): 41 length of query: 484 length of database: 18,247,518 effective HSP length: 106 effective length of query: 378 effective length of database: 14,233,722 effective search space: 5380346916 effective search space used: 5380346916 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.