Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 8051597
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8051597 GA binding protein transcription factor, beta
subunit 1 isoform gamma 1 [Homo sapiens]
(360 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8051597 GA binding protein transcription factor, beta subunit... 699 0.0
gi|8051593 GA binding protein transcription factor, beta subunit... 671 0.0
gi|32483404 GA binding protein transcription factor, beta subuni... 669 0.0
gi|8051599 GA binding protein transcription factor, beta subunit... 669 0.0
gi|8051595 GA binding protein transcription factor, beta subunit... 641 0.0
gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens] 440 e-123
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 97 2e-20
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 96 5e-20
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 92 7e-19
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 92 7e-19
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 92 7e-19
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 92 7e-19
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 92 7e-19
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 92 7e-19
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 91 1e-18
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 91 1e-18
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 91 1e-18
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 84 2e-16
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 84 2e-16
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 84 2e-16
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 83 4e-16
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 82 6e-16
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 82 6e-16
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 82 1e-15
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 82 1e-15
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 82 1e-15
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 82 1e-15
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 82 1e-15
gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens] 79 5e-15
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 79 6e-15
>gi|8051597 GA binding protein transcription factor, beta subunit 1
isoform gamma 1 [Homo sapiens]
Length = 360
Score = 699 bits (1805), Expect = 0.0
Identities = 360/360 (100%), Positives = 360/360 (100%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
Query: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
Query: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
Query: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 360
MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK
Sbjct: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 360
>gi|8051593 GA binding protein transcription factor, beta subunit 1
isoform beta 1 [Homo sapiens]
Length = 395
Score = 671 bits (1731), Expect = 0.0
Identities = 347/350 (99%), Positives = 347/350 (99%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
Query: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
Query: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
Query: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLL 350
MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIE R L
Sbjct: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREAL 350
>gi|32483404 GA binding protein transcription factor, beta subunit 1
isoform gamma 2 [Homo sapiens]
Length = 348
Score = 669 bits (1727), Expect = 0.0
Identities = 348/360 (96%), Positives = 348/360 (96%), Gaps = 12/360 (3%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
Query: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
PQFIIGPGGVVNL TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 228
Query: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 229 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 288
Query: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 360
MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK
Sbjct: 289 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 348
>gi|8051599 GA binding protein transcription factor, beta subunit 1
isoform gamma 2 [Homo sapiens]
Length = 348
Score = 669 bits (1727), Expect = 0.0
Identities = 348/360 (96%), Positives = 348/360 (96%), Gaps = 12/360 (3%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
Query: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
PQFIIGPGGVVNL TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 228
Query: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 229 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 288
Query: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 360
MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK
Sbjct: 289 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 348
>gi|8051595 GA binding protein transcription factor, beta subunit 1
isoform beta 2 [Homo sapiens]
Length = 383
Score = 641 bits (1653), Expect = 0.0
Identities = 335/350 (95%), Positives = 335/350 (95%), Gaps = 12/350 (3%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
Query: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
PQFIIGPGGVVNL TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 228
Query: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 229 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 288
Query: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLL 350
MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIE R L
Sbjct: 289 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREAL 338
>gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens]
Length = 448
Score = 440 bits (1131), Expect = e-123
Identities = 243/359 (67%), Positives = 277/359 (77%), Gaps = 11/359 (3%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGK+LLEAAR GQDDEVR LMANGAPFTTDWLGTSPLHLAAQYGHYST EVLLRA
Sbjct: 1 MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAA++GHA IVE+L+++GADVNAKDMLKMTALHWATE +H++VV
Sbjct: 61 GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT--IHA 178
ELLIKYGADVH SKF K+AFDI+++ N ++ ILQ AMQNQ+N NPE + VT +
Sbjct: 121 ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM 180
Query: 179 ATPQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLS 238
A P FI G VVNL L+SS N+ + + S VQF NS+TSVLATLAALAEAS PLS
Sbjct: 181 AAP-FIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLS 239
Query: 239 NSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH-SIPTSGIGQPI 297
NS TEE++ SVD +IQQV+ SGGQ+VITIVTDG+ LGN+ SIPT GIGQP
Sbjct: 240 NSHRA-TANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPF 298
Query: 298 IVTMPDGQQVLTVPATDIAEETVISEE-----PPAKRQCIEIIENRV-ESAEIEVRSLL 350
IVT+ DGQQVLTVPA +AEETVI EE P K+ I N V ES E R LL
Sbjct: 299 IVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELL 357
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 97.4 bits (241), Expect = 2e-20
Identities = 55/138 (39%), Positives = 80/138 (57%), Gaps = 2/138 (1%)
Query: 9 KLLEAARAGQDDEVRILMA--NGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDA 66
+LLE+AR+G ++++ L+ N +D ++PLHLAA Y ++LL+ G A
Sbjct: 180 ELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHA 239
Query: 67 RTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
+ K D PLH A S GH + E+L+KHGA VNA D+ + T LH A N EV LL+ Y
Sbjct: 240 KDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSY 299
Query: 127 GADVHTQSKFCKTAFDIS 144
GAD + K+A D++
Sbjct: 300 GADPTLLNCHNKSAIDLA 317
Score = 94.4 bits (233), Expect = 1e-19
Identities = 56/152 (36%), Positives = 86/152 (56%), Gaps = 3/152 (1%)
Query: 8 KKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRD 65
++LLEAA+AG + V+ L + D G ++PLH AA Y S E LL+ G
Sbjct: 494 RQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVH 553
Query: 66 ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
A+ K PLH A S GH + E+L+KHGA VN D+ K T LH A E+ +LL++
Sbjct: 554 AKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613
Query: 126 YGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
+GAD +++ T D+ + +G+ D+ ++L+
Sbjct: 614 HGADPTKKNRDGNTPLDL-VKDGDTDIQDLLR 644
Score = 82.8 bits (203), Expect = 4e-16
Identities = 50/139 (35%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
Query: 8 KKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRD 65
++L EA R G + V+ L+ + D G ++PLH AA +G E LL+ G +
Sbjct: 26 RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ 85
Query: 66 ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
AR PLH A S GHA +V +LL+HGAD NA+D T LH A +V +L++
Sbjct: 86 ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145
Query: 126 YGADVHTQSKFCKTAFDIS 144
+GA+ ++ +TA D++
Sbjct: 146 HGAEPTIRNTDGRTALDLA 164
Score = 80.1 bits (196), Expect = 3e-15
Identities = 63/222 (28%), Positives = 107/222 (48%), Gaps = 19/222 (8%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
LL+AA+ G V+ L + D G ++PLHLAA Y + E LL+ G +A+
Sbjct: 649 LLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQ 708
Query: 68 TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
K PLH AAS GH + +L+K+ A VNA D T LH A + ++ LL+ +G
Sbjct: 709 DKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 768
Query: 128 ADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQ-------------NQINTNPESPDTV 174
AD +++ +T D+ +D++ +L AM N + + + D +
Sbjct: 769 ADPTLKNQEGQTPLDLV---SADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADAL 825
Query: 175 TIHAATPQFIIGPGGVVNLTGLVSSENSSKATDET-GVSAVQ 215
+ ++P + + NL+G S +S ++ T G S+++
Sbjct: 826 SSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLE 867
Score = 75.1 bits (183), Expect = 9e-14
Identities = 57/157 (36%), Positives = 80/157 (50%), Gaps = 12/157 (7%)
Query: 7 GKKLLEAARAGQDDEVRI---LMANGAPFTTDWLGTSPLHLAAQYGH---YSTTEVLLRA 60
G LL+AAR + D RI L F + LH AA + E+LLR
Sbjct: 332 GHSLLQAAR--EADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRK 389
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
G + + +TK TPLH+A+ + H +VEV++KH A VNA D L T+LH A H +
Sbjct: 390 GANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTC 449
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
LL+ YG D + S TA + GNE++ ++LQ
Sbjct: 450 RLLLSYGCDPNIISLQGFTALQM----GNENVQQLLQ 482
Score = 70.1 bits (170), Expect = 3e-12
Identities = 58/199 (29%), Positives = 82/199 (41%), Gaps = 55/199 (27%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G+ D V L+ NGA D G PLH A +GH +LLR G +AR +
Sbjct: 65 AAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWN 124
Query: 72 RTPLHMAASEGHASIVEVLLKHG----------------ADVNAKDML------------ 103
TPLH AA +G + VLL+HG AD +AK +L
Sbjct: 125 YTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLES 184
Query: 104 --------------------------KMTALHWATEHNHQEVVELLIKYGADVHTQSKFC 137
K T LH A +N ++V+LL+++GADVH + K
Sbjct: 185 ARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGD 244
Query: 138 KTAFDISIDNGNEDLAEIL 156
+ G+ ++ E+L
Sbjct: 245 LVPLHNACSYGHYEVTELL 263
Score = 58.5 bits (140), Expect = 9e-09
Identities = 32/84 (38%), Positives = 47/84 (55%)
Query: 73 TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
TPLH AA G +VE LL++GA+V A+D + LH A H EVV LL+++GAD +
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
Query: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
+ + T + G D+ +L
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVL 143
Score = 49.3 bits (116), Expect = 5e-06
Identities = 47/173 (27%), Positives = 73/173 (42%), Gaps = 30/173 (17%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A+ +D V +++ + A D LG + LH AA GH T +LL G + +
Sbjct: 407 ASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG 466
Query: 72 RTPLHM--------------------------AASEGHASIVEVLLKHGADVNAKDM--L 103
T L M AA G V+ L + VN +D+
Sbjct: 467 FTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGR 525
Query: 104 KMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+ T LH+A +N VVE L+++GADVH + K + G+ ++AE+L
Sbjct: 526 QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELL 578
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/112 (29%), Positives = 50/112 (44%), Gaps = 15/112 (13%)
Query: 40 SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNA 99
+PLH+A++ H EV+++ +A + +T LH AA GH +LL +G D N
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 100 KDMLKMTALHWATEHNHQEVVELLIKYG--------------ADVHTQSKFC 137
+ TAL E N Q++++ I G DV T K C
Sbjct: 462 ISLQGFTALQMGNE-NVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 95.9 bits (237), Expect = 5e-20
Identities = 56/155 (36%), Positives = 86/155 (55%), Gaps = 3/155 (1%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGV 62
D+ +LLEA++AG + V+ L ++ D G ++PLH AA Y S E LL G
Sbjct: 649 DVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGA 708
Query: 63 SRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVEL 122
A+ K PLH A S GH + E+L++HGA VN D+ K T LH A E+ +L
Sbjct: 709 DVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKL 768
Query: 123 LIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
L+K+GAD +++ T D+ + G+ D+ ++L+
Sbjct: 769 LLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLLR 802
Score = 94.0 bits (232), Expect = 2e-19
Identities = 55/138 (39%), Positives = 79/138 (57%), Gaps = 2/138 (1%)
Query: 9 KLLEAARAGQDDEVRILMA--NGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDA 66
+LLEAAR+G ++++ L+ N +D ++PLHLAA Y ++LL+ G A
Sbjct: 338 ELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 397
Query: 67 RTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
+ K PLH A S GH + E+LLKHGA VNA D+ + T LH A N EV LL+ +
Sbjct: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457
Query: 127 GADVHTQSKFCKTAFDIS 144
GAD + K+A D++
Sbjct: 458 GADPTLVNCHGKSAVDMA 475
Score = 80.9 bits (198), Expect = 2e-15
Identities = 52/139 (37%), Positives = 74/139 (53%), Gaps = 2/139 (1%)
Query: 8 KKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRD 65
++LLEA R G V+ L+ D G +SPLH AA +G E LL+ G +
Sbjct: 184 RELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH 243
Query: 66 ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
AR PLH A S GHA +V +LL GAD NA+D T LH A +V +L++
Sbjct: 244 ARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 303
Query: 126 YGADVHTQSKFCKTAFDIS 144
+GAD + ++ K+A D++
Sbjct: 304 HGADPNIRNTDGKSALDLA 322
Score = 78.6 bits (192), Expect = 8e-15
Identities = 60/194 (30%), Positives = 90/194 (46%), Gaps = 11/194 (5%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
LL+AA+ G V+ L D G ++PLHLAA Y + E LL G +A+
Sbjct: 807 LLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ 866
Query: 68 TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
K PLH AAS GH I +L+K+ VNA D T LH A + ++ LL+ +G
Sbjct: 867 DKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 926
Query: 128 ADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIH------AATP 181
AD +++ +T D++ +D+ +L AM + P + A+TP
Sbjct: 927 ADPTMKNQEGQTPLDLAT---ADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTP 983
Query: 182 QFIIGPGGVVNLTG 195
+ + NLTG
Sbjct: 984 SCLSAASSIDNLTG 997
Score = 75.1 bits (183), Expect = 9e-14
Identities = 57/154 (37%), Positives = 76/154 (49%), Gaps = 8/154 (5%)
Query: 7 GKKLLEAARAGQDDEVRILMA-NGAPFTTDWLGTSPLHLAAQYGH---YSTTEVLLRAGV 62
G LL+AAR +V+ +A F + LH A H TE+LLR G
Sbjct: 490 GHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549
Query: 63 SRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVEL 122
+ + + K TPLH+AA H ++EVL KHGA +NA D L TALH A H + L
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609
Query: 123 LIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
L+ YG+D S TA + GNE + +IL
Sbjct: 610 LLSYGSDPSIISLQGFTAAQM----GNEAVQQIL 639
Score = 63.2 bits (152), Expect = 4e-10
Identities = 56/199 (28%), Positives = 79/199 (39%), Gaps = 55/199 (27%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G+ D V L+ GA D G PLH A +GH +LL G +AR +
Sbjct: 223 AAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWN 282
Query: 72 RTPLHMAASEGHASIVEVLLKHG----------------ADVNAKDML------------ 103
TPLH AA +G + VLL+HG AD +AK +L
Sbjct: 283 YTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEA 342
Query: 104 --------------------------KMTALHWATEHNHQEVVELLIKYGADVHTQSKFC 137
K T LH A +N +V+LL+++GADVH + K
Sbjct: 343 ARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG 402
Query: 138 KTAFDISIDNGNEDLAEIL 156
+ G+ ++ E+L
Sbjct: 403 LVPLHNACSYGHYEVTELL 421
Score = 52.4 bits (124), Expect = 6e-07
Identities = 31/84 (36%), Positives = 45/84 (53%)
Query: 73 TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
+PLH AA G +VE LL+ GA+V+A+D + LH A H EVV LL+ GAD +
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 277
Query: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
+ + T + G D+ +L
Sbjct: 278 RDNWNYTPLHEAAIKGKIDVCIVL 301
Score = 47.8 bits (112), Expect = 2e-05
Identities = 27/82 (32%), Positives = 40/82 (48%)
Query: 40 SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNA 99
+PLH+AA+ H EVL + G +A + +T LH AA GH +LL +G+D +
Sbjct: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
Query: 100 KDMLKMTALHWATEHNHQEVVE 121
+ TA E Q + E
Sbjct: 620 ISLQGFTAAQMGNEAVQQILSE 641
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 92.0 bits (227), Expect = 7e-19
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G + V +L++ A + G +PLHL AQ GH +VL++ GV DA T++
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ G+ +V+ LL+H ADVNAK L + LH A + H ++V LL+K GA +
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
S T I+ G + ++L++
Sbjct: 795 EVSSDGTTPLAIAKRLGYISVTDVLKV 821
Score = 91.3 bits (225), Expect = 1e-18
Identities = 60/198 (30%), Positives = 99/198 (50%), Gaps = 14/198 (7%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ Q + R L+ G + + G +PLHLAAQ GH +LL + + K
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ A EGH + +VL+KHG V+A + T LH A+ + + ++V+ L+++ ADV+
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K + + G+ D+ +L N SP+ V+ TP I G +
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 813
Query: 192 NLTGLVSSENSSKATDET 209
++T ++ TDET
Sbjct: 814 SVTDVL-----KVVTDET 826
Score = 87.0 bits (214), Expect = 2e-17
Identities = 59/192 (30%), Positives = 93/192 (48%), Gaps = 9/192 (4%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G + V++L+ N A P G +PLH+AA+ GH T LL S+ TK
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA G + E+LL+ A NA +T LH A HN+ ++V+LL+ G H
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+ + T I+ ++ E+ + +Q + N ES + TP + G
Sbjct: 630 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAES-----VQGVTPLHLAAQEGHA 681
Query: 192 NLTGLVSSENSS 203
+ L+ S+ ++
Sbjct: 682 EMVALLLSKQAN 693
Score = 86.3 bits (212), Expect = 4e-17
Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 10/200 (5%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ GA P + G +PLH+A + H E+LL+ G S DA T+
Sbjct: 378 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 437
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ GH IV+ LL+ GA N ++ T LH A H EV + L++ A V+
Sbjct: 438 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 497
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIG-PGGV 190
++K +T + G+ ++ ++L ++N N P+ T TP I G V
Sbjct: 498 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 549
Query: 191 VNLTGLVSSENSSKATDETG 210
+ L+ E S + G
Sbjct: 550 ETVLALLEKEASQACMTKKG 569
Score = 84.0 bits (206), Expect = 2e-16
Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 4/152 (2%)
Query: 20 DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
D V++L+ G +P + W G +PLH+AA+ LL+ G S +A + TPLH+A
Sbjct: 616 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 675
Query: 79 ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
A EGHA +V +LL A+ N + +T LH + H V ++LIK+G V ++
Sbjct: 676 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 735
Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPES 170
T ++ GN L + L +Q+Q + N ++
Sbjct: 736 TPLHVASHYGNIKLVKFL---LQHQADVNAKT 764
Score = 83.6 bits (205), Expect = 3e-16
Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 23/243 (9%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AAR+G D+ + NG T + G + LHLA++ GH LL +
Sbjct: 44 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 103
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
+ TK T LH+AA G +V L+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
++ GA+ + ++ T +++ G+E++ L IA +N
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 223
Query: 164 -INTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAVQFGNSST 221
+ N +PD ++ TP I +N+ L+ + +S T + G++ + +
Sbjct: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283
Query: 222 SVL 224
+V+
Sbjct: 284 NVI 286
Score = 80.5 bits (197), Expect = 2e-15
Identities = 44/135 (32%), Positives = 75/135 (55%), Gaps = 1/135 (0%)
Query: 23 RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
++L+ GA T G +PLH+A++ G+ +LL G + +TK + TPLH AA
Sbjct: 256 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 315
Query: 82 GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
GH I E+LL HGA + AK ++ +H A + +H + V LL++Y A++ + T
Sbjct: 316 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 375
Query: 142 DISIDNGNEDLAEIL 156
++ G+ +A++L
Sbjct: 376 HVAAHCGHHRVAKVL 390
Score = 80.5 bits (197), Expect = 2e-15
Identities = 63/198 (31%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AA+ D VR+L+ A T D L +PLH+AA GH+ +VLL G ++R
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 402
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + H ++E+LLK GA ++A +T LH A+ H +V+ L++ GA
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 462
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
+ + +T ++ G+ ++A+ L +QN+ N ++ D T +H A IG
Sbjct: 463 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 516
Query: 189 GVVNLTGLVSSENSSKAT 206
+V L L ++ N + AT
Sbjct: 517 NMVKLL-LENNANPNLAT 533
Score = 78.6 bits (192), Expect = 8e-15
Identities = 56/162 (34%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G IL+ +GAP G SP+H+AAQ H +LL+ D T
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA GH + +VLL GA N++ + T LH A + NH V+ELL+K GA +
Sbjct: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP 171
++ T ++ G+ + + L + A N N E+P
Sbjct: 432 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 473
Score = 73.6 bits (179), Expect = 3e-13
Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 13/202 (6%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A+R G VR+L+ GA T +PLH AA+ GH +E+LL G A+TK
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+P+HMAA H V +LL++ A+++ + +T LH A H V ++L+ GA +
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG-- 189
+++ T I+ + + E+L + T S D VT TP + G
Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELL-------LKTG-ASIDAVTESGLTPLHVASFMGHL 450
Query: 190 --VVNLTGLVSSENSSKATDET 209
V NL +S N S ET
Sbjct: 451 PIVKNLLQRGASPNVSNVKVET 472
Score = 72.4 bits (176), Expect = 6e-13
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)
Query: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
+L +P ++ +PLH+AA+ GH + LL+ +A+ K D+TPLH AA GH
Sbjct: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 515
Query: 84 ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
++V++LL++ A+ N T LH A H E V L++ A +K T +
Sbjct: 516 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 575
Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
+ G +AE+L + A N N +P V +H
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 611
Score = 71.6 bits (174), Expect = 1e-12
Identities = 42/134 (31%), Positives = 71/134 (52%), Gaps = 5/134 (3%)
Query: 7 GKKLLEAAR-AGQDDEVR----ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
GK L A A ++D+ R +L + P G +PLH+AA Y + + ++LL G
Sbjct: 203 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 262
Query: 62 VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
S + + TPLH+A+ G+ +V +LL GA + K ++T LH A + H + E
Sbjct: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322
Query: 122 LLIKYGADVHTQSK 135
+L+ +GA + ++K
Sbjct: 323 ILLDHGAPIQAKTK 336
Score = 71.6 bits (174), Expect = 1e-12
Identities = 64/244 (26%), Positives = 101/244 (41%), Gaps = 11/244 (4%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
+S V + L AARAG + + L+ N A +PLH AA+ GH + ++LL
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+ + T TPLH+AA EGH V LL+ A T LH A ++ V
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 584
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
ELL++ A + K T +++ + N D+ ++L SP + +
Sbjct: 585 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 636
Query: 180 TPQFIIGPGGVVNLT-GLVSSENSSKATDETGVSAVQF-GNSSTSVLATLAALAEASAPL 237
TP I V + L+ S+ A GV+ + + + L +A+ L
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696
Query: 238 SNSS 241
N S
Sbjct: 697 GNKS 700
Score = 65.5 bits (158), Expect = 7e-11
Identities = 41/145 (28%), Positives = 71/145 (48%), Gaps = 1/145 (0%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G+ +L+ A P G +PLH+A + + ++LL G S +
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + + LL++G NA+ + +T LH A + H E+V LL+ A+ +
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
+K T + G+ +A++L
Sbjct: 696 LGNKSGLTPLHLVAQEGHVPVADVL 720
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/115 (33%), Positives = 62/115 (53%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
LH+AA+ T VLL+ + D +K TPLH+AA + ++ ++LL GA VN
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+T LH A+ + +V LL+ GA + T++K T + NG+ ++EIL
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324
Score = 58.5 bits (140), Expect = 9e-09
Identities = 49/174 (28%), Positives = 75/174 (43%), Gaps = 30/174 (17%)
Query: 13 AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA AGQD+ VR L+ GA G +PL++AAQ H + LL G +++ T+
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177
Query: 72 RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
TPL +A +GH ++V L+ +G D N + K
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237
Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
T LH A + + V +LL+ GA V+ + T I+ GN + +L
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 291
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 92.0 bits (227), Expect = 7e-19
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G + V +L++ A + G +PLHL AQ GH +VL++ GV DA T++
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ G+ +V+ LL+H ADVNAK L + LH A + H ++V LL+K GA +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
S T I+ G + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788
Score = 91.3 bits (225), Expect = 1e-18
Identities = 60/198 (30%), Positives = 99/198 (50%), Gaps = 14/198 (7%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ Q + R L+ G + + G +PLHLAAQ GH +LL + + K
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ A EGH + +VL+KHG V+A + T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K + + G+ D+ +L N SP+ V+ TP I G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 192 NLTGLVSSENSSKATDET 209
++T ++ TDET
Sbjct: 781 SVTDVL-----KVVTDET 793
Score = 87.0 bits (214), Expect = 2e-17
Identities = 59/192 (30%), Positives = 93/192 (48%), Gaps = 9/192 (4%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G + V++L+ N A P G +PLH+AA+ GH T LL S+ TK
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA G + E+LL+ A NA +T LH A HN+ ++V+LL+ G H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+ + T I+ ++ E+ + +Q + N ES + TP + G
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAES-----VQGVTPLHLAAQEGHA 648
Query: 192 NLTGLVSSENSS 203
+ L+ S+ ++
Sbjct: 649 EMVALLLSKQAN 660
Score = 86.3 bits (212), Expect = 4e-17
Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 10/200 (5%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ GA P + G +PLH+A + H E+LL+ G S DA T+
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ GH IV+ LL+ GA N ++ T LH A H EV + L++ A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIG-PGGV 190
++K +T + G+ ++ ++L ++N N P+ T TP I G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516
Query: 191 VNLTGLVSSENSSKATDETG 210
+ L+ E S + G
Sbjct: 517 ETVLALLEKEASQACMTKKG 536
Score = 84.0 bits (206), Expect = 2e-16
Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 4/152 (2%)
Query: 20 DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
D V++L+ G +P + W G +PLH+AA+ LL+ G S +A + TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 79 ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
A EGHA +V +LL A+ N + +T LH + H V ++LIK+G V ++
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPES 170
T ++ GN L + L +Q+Q + N ++
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKT 731
Score = 83.6 bits (205), Expect = 3e-16
Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 23/243 (9%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AAR+G D+ + NG T + G + LHLA++ GH LL +
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
+ TK T LH+AA G +V L+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
++ GA+ + ++ T +++ G+E++ L IA +N
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 164 -INTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAVQFGNSST 221
+ N +PD ++ TP I +N+ L+ + +S T + G++ + +
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 222 SVL 224
+V+
Sbjct: 251 NVI 253
Score = 80.5 bits (197), Expect = 2e-15
Identities = 44/135 (32%), Positives = 75/135 (55%), Gaps = 1/135 (0%)
Query: 23 RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
++L+ GA T G +PLH+A++ G+ +LL G + +TK + TPLH AA
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 82 GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
GH I E+LL HGA + AK ++ +H A + +H + V LL++Y A++ + T
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 142 DISIDNGNEDLAEIL 156
++ G+ +A++L
Sbjct: 343 HVAAHCGHHRVAKVL 357
Score = 80.5 bits (197), Expect = 2e-15
Identities = 63/198 (31%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AA+ D VR+L+ A T D L +PLH+AA GH+ +VLL G ++R
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + H ++E+LLK GA ++A +T LH A+ H +V+ L++ GA
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
+ + +T ++ G+ ++A+ L +QN+ N ++ D T +H A IG
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483
Query: 189 GVVNLTGLVSSENSSKAT 206
+V L L ++ N + AT
Sbjct: 484 NMVKLL-LENNANPNLAT 500
Score = 78.6 bits (192), Expect = 8e-15
Identities = 56/162 (34%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G IL+ +GAP G SP+H+AAQ H +LL+ D T
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA GH + +VLL GA N++ + T LH A + NH V+ELL+K GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP 171
++ T ++ G+ + + L + A N N E+P
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Score = 73.6 bits (179), Expect = 3e-13
Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 13/202 (6%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A+R G VR+L+ GA T +PLH AA+ GH +E+LL G A+TK
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+P+HMAA H V +LL++ A+++ + +T LH A H V ++L+ GA +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG-- 189
+++ T I+ + + E+L + T S D VT TP + G
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL-------LKTG-ASIDAVTESGLTPLHVASFMGHL 417
Query: 190 --VVNLTGLVSSENSSKATDET 209
V NL +S N S ET
Sbjct: 418 PIVKNLLQRGASPNVSNVKVET 439
Score = 72.4 bits (176), Expect = 6e-13
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)
Query: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
+L +P ++ +PLH+AA+ GH + LL+ +A+ K D+TPLH AA GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 84 ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
++V++LL++ A+ N T LH A H E V L++ A +K T +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
+ G +AE+L + A N N +P V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 71.6 bits (174), Expect = 1e-12
Identities = 42/134 (31%), Positives = 71/134 (52%), Gaps = 5/134 (3%)
Query: 7 GKKLLEAAR-AGQDDEVR----ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
GK L A A ++D+ R +L + P G +PLH+AA Y + + ++LL G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 62 VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
S + + TPLH+A+ G+ +V +LL GA + K ++T LH A + H + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 122 LLIKYGADVHTQSK 135
+L+ +GA + ++K
Sbjct: 290 ILLDHGAPIQAKTK 303
Score = 71.6 bits (174), Expect = 1e-12
Identities = 64/244 (26%), Positives = 101/244 (41%), Gaps = 11/244 (4%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
+S V + L AARAG + + L+ N A +PLH AA+ GH + ++LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+ + T TPLH+AA EGH V LL+ A T LH A ++ V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
ELL++ A + K T +++ + N D+ ++L SP + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603
Query: 180 TPQFIIGPGGVVNLT-GLVSSENSSKATDETGVSAVQF-GNSSTSVLATLAALAEASAPL 237
TP I V + L+ S+ A GV+ + + + L +A+ L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 238 SNSS 241
N S
Sbjct: 664 GNKS 667
Score = 67.0 bits (162), Expect = 2e-11
Identities = 75/334 (22%), Positives = 143/334 (42%), Gaps = 34/334 (10%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G+ +L+ A P G +PLH+A + + ++LL G S +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + + LL++G NA+ + +T LH A + H E+V LL+ A+ +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+K T + G+ +A++L +++ + D T TP + G +
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVL---IKHGVMV-----DATTRMGYTPLHVASHYGNI 714
Query: 192 NLTG-LVSSENSSKATDETGVS----AVQFGNSSTSVLATLAALAEASAPLSNSSETPVV 246
L L+ + A + G S A Q G+ T ++ L + +S+ TP+
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTLLLKNGASPNEVSSDGTTPLA 772
Query: 247 ATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH--SIPTSGIGQPIIVTMPDG 304
+ + D +V+T T + + + H S P + + + + V+ +G
Sbjct: 773 IAKRLGYISVTDVL----------KVVTDETSFVLVSDKHRMSFPET-VDEILDVSEDEG 821
Query: 305 QQVLTVPA-----TDIAEETVISEEPPAKRQCIE 333
+++++ A D+ EE + + P Q +E
Sbjct: 822 EELISFKAERRDSRDVDEEKELLDFVPKLDQVVE 855
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/115 (33%), Positives = 62/115 (53%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
LH+AA+ T VLL+ + D +K TPLH+AA + ++ ++LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+T LH A+ + +V LL+ GA + T++K T + NG+ ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 58.5 bits (140), Expect = 9e-09
Identities = 49/174 (28%), Positives = 75/174 (43%), Gaps = 30/174 (17%)
Query: 13 AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA AGQD+ VR L+ GA G +PL++AAQ H + LL G +++ T+
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 72 RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
TPL +A +GH ++V L+ +G D N + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
T LH A + + V +LL+ GA V+ + T I+ GN + +L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 92.0 bits (227), Expect = 7e-19
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G + V +L++ A + G +PLHL AQ GH +VL++ GV DA T++
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ G+ +V+ LL+H ADVNAK L + LH A + H ++V LL+K GA +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
S T I+ G + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788
Score = 91.3 bits (225), Expect = 1e-18
Identities = 60/198 (30%), Positives = 99/198 (50%), Gaps = 14/198 (7%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ Q + R L+ G + + G +PLHLAAQ GH +LL + + K
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ A EGH + +VL+KHG V+A + T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K + + G+ D+ +L N SP+ V+ TP I G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 192 NLTGLVSSENSSKATDET 209
++T ++ TDET
Sbjct: 781 SVTDVL-----KVVTDET 793
Score = 87.0 bits (214), Expect = 2e-17
Identities = 59/192 (30%), Positives = 93/192 (48%), Gaps = 9/192 (4%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G + V++L+ N A P G +PLH+AA+ GH T LL S+ TK
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA G + E+LL+ A NA +T LH A HN+ ++V+LL+ G H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+ + T I+ ++ E+ + +Q + N ES + TP + G
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAES-----VQGVTPLHLAAQEGHA 648
Query: 192 NLTGLVSSENSS 203
+ L+ S+ ++
Sbjct: 649 EMVALLLSKQAN 660
Score = 86.3 bits (212), Expect = 4e-17
Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 10/200 (5%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ GA P + G +PLH+A + H E+LL+ G S DA T+
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ GH IV+ LL+ GA N ++ T LH A H EV + L++ A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIG-PGGV 190
++K +T + G+ ++ ++L ++N N P+ T TP I G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516
Query: 191 VNLTGLVSSENSSKATDETG 210
+ L+ E S + G
Sbjct: 517 ETVLALLEKEASQACMTKKG 536
Score = 84.0 bits (206), Expect = 2e-16
Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 4/152 (2%)
Query: 20 DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
D V++L+ G +P + W G +PLH+AA+ LL+ G S +A + TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 79 ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
A EGHA +V +LL A+ N + +T LH + H V ++LIK+G V ++
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPES 170
T ++ GN L + L +Q+Q + N ++
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKT 731
Score = 83.6 bits (205), Expect = 3e-16
Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 23/243 (9%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AAR+G D+ + NG T + G + LHLA++ GH LL +
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
+ TK T LH+AA G +V L+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
++ GA+ + ++ T +++ G+E++ L IA +N
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 164 -INTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAVQFGNSST 221
+ N +PD ++ TP I +N+ L+ + +S T + G++ + +
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 222 SVL 224
+V+
Sbjct: 251 NVI 253
Score = 80.5 bits (197), Expect = 2e-15
Identities = 44/135 (32%), Positives = 75/135 (55%), Gaps = 1/135 (0%)
Query: 23 RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
++L+ GA T G +PLH+A++ G+ +LL G + +TK + TPLH AA
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 82 GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
GH I E+LL HGA + AK ++ +H A + +H + V LL++Y A++ + T
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 142 DISIDNGNEDLAEIL 156
++ G+ +A++L
Sbjct: 343 HVAAHCGHHRVAKVL 357
Score = 80.5 bits (197), Expect = 2e-15
Identities = 63/198 (31%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AA+ D VR+L+ A T D L +PLH+AA GH+ +VLL G ++R
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + H ++E+LLK GA ++A +T LH A+ H +V+ L++ GA
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
+ + +T ++ G+ ++A+ L +QN+ N ++ D T +H A IG
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483
Query: 189 GVVNLTGLVSSENSSKAT 206
+V L L ++ N + AT
Sbjct: 484 NMVKLL-LENNANPNLAT 500
Score = 78.6 bits (192), Expect = 8e-15
Identities = 56/162 (34%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G IL+ +GAP G SP+H+AAQ H +LL+ D T
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA GH + +VLL GA N++ + T LH A + NH V+ELL+K GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP 171
++ T ++ G+ + + L + A N N E+P
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Score = 73.6 bits (179), Expect = 3e-13
Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 13/202 (6%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A+R G VR+L+ GA T +PLH AA+ GH +E+LL G A+TK
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+P+HMAA H V +LL++ A+++ + +T LH A H V ++L+ GA +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG-- 189
+++ T I+ + + E+L + T S D VT TP + G
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL-------LKTG-ASIDAVTESGLTPLHVASFMGHL 417
Query: 190 --VVNLTGLVSSENSSKATDET 209
V NL +S N S ET
Sbjct: 418 PIVKNLLQRGASPNVSNVKVET 439
Score = 72.4 bits (176), Expect = 6e-13
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)
Query: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
+L +P ++ +PLH+AA+ GH + LL+ +A+ K D+TPLH AA GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 84 ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
++V++LL++ A+ N T LH A H E V L++ A +K T +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
+ G +AE+L + A N N +P V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 71.6 bits (174), Expect = 1e-12
Identities = 42/134 (31%), Positives = 71/134 (52%), Gaps = 5/134 (3%)
Query: 7 GKKLLEAAR-AGQDDEVR----ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
GK L A A ++D+ R +L + P G +PLH+AA Y + + ++LL G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 62 VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
S + + TPLH+A+ G+ +V +LL GA + K ++T LH A + H + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 122 LLIKYGADVHTQSK 135
+L+ +GA + ++K
Sbjct: 290 ILLDHGAPIQAKTK 303
Score = 71.6 bits (174), Expect = 1e-12
Identities = 64/244 (26%), Positives = 101/244 (41%), Gaps = 11/244 (4%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
+S V + L AARAG + + L+ N A +PLH AA+ GH + ++LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+ + T TPLH+AA EGH V LL+ A T LH A ++ V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
ELL++ A + K T +++ + N D+ ++L SP + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603
Query: 180 TPQFIIGPGGVVNLT-GLVSSENSSKATDETGVSAVQF-GNSSTSVLATLAALAEASAPL 237
TP I V + L+ S+ A GV+ + + + L +A+ L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 238 SNSS 241
N S
Sbjct: 664 GNKS 667
Score = 67.0 bits (162), Expect = 2e-11
Identities = 75/334 (22%), Positives = 143/334 (42%), Gaps = 34/334 (10%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G+ +L+ A P G +PLH+A + + ++LL G S +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + + LL++G NA+ + +T LH A + H E+V LL+ A+ +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+K T + G+ +A++L +++ + D T TP + G +
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVL---IKHGVMV-----DATTRMGYTPLHVASHYGNI 714
Query: 192 NLTG-LVSSENSSKATDETGVS----AVQFGNSSTSVLATLAALAEASAPLSNSSETPVV 246
L L+ + A + G S A Q G+ T ++ L + +S+ TP+
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTLLLKNGASPNEVSSDGTTPLA 772
Query: 247 ATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH--SIPTSGIGQPIIVTMPDG 304
+ + D +V+T T + + + H S P + + + + V+ +G
Sbjct: 773 IAKRLGYISVTDVL----------KVVTDETSFVLVSDKHRMSFPET-VDEILDVSEDEG 821
Query: 305 QQVLTVPA-----TDIAEETVISEEPPAKRQCIE 333
+++++ A D+ EE + + P Q +E
Sbjct: 822 EELISFKAERRDSRDVDEEKELLDFVPKLDQVVE 855
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/115 (33%), Positives = 62/115 (53%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
LH+AA+ T VLL+ + D +K TPLH+AA + ++ ++LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+T LH A+ + +V LL+ GA + T++K T + NG+ ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 58.5 bits (140), Expect = 9e-09
Identities = 49/174 (28%), Positives = 75/174 (43%), Gaps = 30/174 (17%)
Query: 13 AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA AGQD+ VR L+ GA G +PL++AAQ H + LL G +++ T+
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 72 RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
TPL +A +GH ++V L+ +G D N + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
T LH A + + V +LL+ GA V+ + T I+ GN + +L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 92.0 bits (227), Expect = 7e-19
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G + V +L++ A + G +PLHL AQ GH +VL++ GV DA T++
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ G+ +V+ LL+H ADVNAK L + LH A + H ++V LL+K GA +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
S T I+ G + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788
Score = 91.3 bits (225), Expect = 1e-18
Identities = 60/198 (30%), Positives = 99/198 (50%), Gaps = 14/198 (7%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ Q + R L+ G + + G +PLHLAAQ GH +LL + + K
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ A EGH + +VL+KHG V+A + T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K + + G+ D+ +L N SP+ V+ TP I G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 192 NLTGLVSSENSSKATDET 209
++T ++ TDET
Sbjct: 781 SVTDVL-----KVVTDET 793
Score = 87.0 bits (214), Expect = 2e-17
Identities = 59/192 (30%), Positives = 93/192 (48%), Gaps = 9/192 (4%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G + V++L+ N A P G +PLH+AA+ GH T LL S+ TK
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA G + E+LL+ A NA +T LH A HN+ ++V+LL+ G H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+ + T I+ ++ E+ + +Q + N ES + TP + G
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAES-----VQGVTPLHLAAQEGHA 648
Query: 192 NLTGLVSSENSS 203
+ L+ S+ ++
Sbjct: 649 EMVALLLSKQAN 660
Score = 86.3 bits (212), Expect = 4e-17
Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 10/200 (5%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ GA P + G +PLH+A + H E+LL+ G S DA T+
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ GH IV+ LL+ GA N ++ T LH A H EV + L++ A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIG-PGGV 190
++K +T + G+ ++ ++L ++N N P+ T TP I G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516
Query: 191 VNLTGLVSSENSSKATDETG 210
+ L+ E S + G
Sbjct: 517 ETVLALLEKEASQACMTKKG 536
Score = 84.0 bits (206), Expect = 2e-16
Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 4/152 (2%)
Query: 20 DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
D V++L+ G +P + W G +PLH+AA+ LL+ G S +A + TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 79 ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
A EGHA +V +LL A+ N + +T LH + H V ++LIK+G V ++
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPES 170
T ++ GN L + L +Q+Q + N ++
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKT 731
Score = 83.6 bits (205), Expect = 3e-16
Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 23/243 (9%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AAR+G D+ + NG T + G + LHLA++ GH LL +
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
+ TK T LH+AA G +V L+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
++ GA+ + ++ T +++ G+E++ L IA +N
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 164 -INTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAVQFGNSST 221
+ N +PD ++ TP I +N+ L+ + +S T + G++ + +
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 222 SVL 224
+V+
Sbjct: 251 NVI 253
Score = 80.5 bits (197), Expect = 2e-15
Identities = 44/135 (32%), Positives = 75/135 (55%), Gaps = 1/135 (0%)
Query: 23 RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
++L+ GA T G +PLH+A++ G+ +LL G + +TK + TPLH AA
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 82 GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
GH I E+LL HGA + AK ++ +H A + +H + V LL++Y A++ + T
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 142 DISIDNGNEDLAEIL 156
++ G+ +A++L
Sbjct: 343 HVAAHCGHHRVAKVL 357
Score = 80.5 bits (197), Expect = 2e-15
Identities = 63/198 (31%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AA+ D VR+L+ A T D L +PLH+AA GH+ +VLL G ++R
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + H ++E+LLK GA ++A +T LH A+ H +V+ L++ GA
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
+ + +T ++ G+ ++A+ L +QN+ N ++ D T +H A IG
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483
Query: 189 GVVNLTGLVSSENSSKAT 206
+V L L ++ N + AT
Sbjct: 484 NMVKLL-LENNANPNLAT 500
Score = 78.6 bits (192), Expect = 8e-15
Identities = 56/162 (34%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G IL+ +GAP G SP+H+AAQ H +LL+ D T
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA GH + +VLL GA N++ + T LH A + NH V+ELL+K GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP 171
++ T ++ G+ + + L + A N N E+P
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Score = 73.6 bits (179), Expect = 3e-13
Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 13/202 (6%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A+R G VR+L+ GA T +PLH AA+ GH +E+LL G A+TK
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+P+HMAA H V +LL++ A+++ + +T LH A H V ++L+ GA +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG-- 189
+++ T I+ + + E+L + T S D VT TP + G
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL-------LKTG-ASIDAVTESGLTPLHVASFMGHL 417
Query: 190 --VVNLTGLVSSENSSKATDET 209
V NL +S N S ET
Sbjct: 418 PIVKNLLQRGASPNVSNVKVET 439
Score = 72.4 bits (176), Expect = 6e-13
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)
Query: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
+L +P ++ +PLH+AA+ GH + LL+ +A+ K D+TPLH AA GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 84 ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
++V++LL++ A+ N T LH A H E V L++ A +K T +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
+ G +AE+L + A N N +P V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 71.6 bits (174), Expect = 1e-12
Identities = 42/134 (31%), Positives = 71/134 (52%), Gaps = 5/134 (3%)
Query: 7 GKKLLEAAR-AGQDDEVR----ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
GK L A A ++D+ R +L + P G +PLH+AA Y + + ++LL G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 62 VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
S + + TPLH+A+ G+ +V +LL GA + K ++T LH A + H + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 122 LLIKYGADVHTQSK 135
+L+ +GA + ++K
Sbjct: 290 ILLDHGAPIQAKTK 303
Score = 71.6 bits (174), Expect = 1e-12
Identities = 64/244 (26%), Positives = 101/244 (41%), Gaps = 11/244 (4%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
+S V + L AARAG + + L+ N A +PLH AA+ GH + ++LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+ + T TPLH+AA EGH V LL+ A T LH A ++ V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
ELL++ A + K T +++ + N D+ ++L SP + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603
Query: 180 TPQFIIGPGGVVNLT-GLVSSENSSKATDETGVSAVQF-GNSSTSVLATLAALAEASAPL 237
TP I V + L+ S+ A GV+ + + + L +A+ L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 238 SNSS 241
N S
Sbjct: 664 GNKS 667
Score = 67.0 bits (162), Expect = 2e-11
Identities = 75/334 (22%), Positives = 143/334 (42%), Gaps = 34/334 (10%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G+ +L+ A P G +PLH+A + + ++LL G S +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + + LL++G NA+ + +T LH A + H E+V LL+ A+ +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+K T + G+ +A++L +++ + D T TP + G +
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVL---IKHGVMV-----DATTRMGYTPLHVASHYGNI 714
Query: 192 NLTG-LVSSENSSKATDETGVS----AVQFGNSSTSVLATLAALAEASAPLSNSSETPVV 246
L L+ + A + G S A Q G+ T ++ L + +S+ TP+
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTLLLKNGASPNEVSSDGTTPLA 772
Query: 247 ATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH--SIPTSGIGQPIIVTMPDG 304
+ + D +V+T T + + + H S P + + + + V+ +G
Sbjct: 773 IAKRLGYISVTDVL----------KVVTDETSFVLVSDKHRMSFPET-VDEILDVSEDEG 821
Query: 305 QQVLTVPA-----TDIAEETVISEEPPAKRQCIE 333
+++++ A D+ EE + + P Q +E
Sbjct: 822 EELISFKAERRDSRDVDEEKELLDFVPKLDQVVE 855
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/115 (33%), Positives = 62/115 (53%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
LH+AA+ T VLL+ + D +K TPLH+AA + ++ ++LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+T LH A+ + +V LL+ GA + T++K T + NG+ ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 58.5 bits (140), Expect = 9e-09
Identities = 49/174 (28%), Positives = 75/174 (43%), Gaps = 30/174 (17%)
Query: 13 AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA AGQD+ VR L+ GA G +PL++AAQ H + LL G +++ T+
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 72 RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
TPL +A +GH ++V L+ +G D N + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
T LH A + + V +LL+ GA V+ + T I+ GN + +L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 92.0 bits (227), Expect = 7e-19
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G + V +L++ A + G +PLHL AQ GH +VL++ GV DA T++
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ G+ +V+ LL+H ADVNAK L + LH A + H ++V LL+K GA +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
S T I+ G + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788
Score = 91.3 bits (225), Expect = 1e-18
Identities = 60/198 (30%), Positives = 99/198 (50%), Gaps = 14/198 (7%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ Q + R L+ G + + G +PLHLAAQ GH +LL + + K
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ A EGH + +VL+KHG V+A + T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K + + G+ D+ +L N SP+ V+ TP I G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 192 NLTGLVSSENSSKATDET 209
++T ++ TDET
Sbjct: 781 SVTDVL-----KVVTDET 793
Score = 87.0 bits (214), Expect = 2e-17
Identities = 59/192 (30%), Positives = 93/192 (48%), Gaps = 9/192 (4%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G + V++L+ N A P G +PLH+AA+ GH T LL S+ TK
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA G + E+LL+ A NA +T LH A HN+ ++V+LL+ G H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+ + T I+ ++ E+ + +Q + N ES + TP + G
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAES-----VQGVTPLHLAAQEGHA 648
Query: 192 NLTGLVSSENSS 203
+ L+ S+ ++
Sbjct: 649 EMVALLLSKQAN 660
Score = 86.3 bits (212), Expect = 4e-17
Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 10/200 (5%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ GA P + G +PLH+A + H E+LL+ G S DA T+
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ GH IV+ LL+ GA N ++ T LH A H EV + L++ A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIG-PGGV 190
++K +T + G+ ++ ++L ++N N P+ T TP I G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516
Query: 191 VNLTGLVSSENSSKATDETG 210
+ L+ E S + G
Sbjct: 517 ETVLALLEKEASQACMTKKG 536
Score = 84.0 bits (206), Expect = 2e-16
Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 4/152 (2%)
Query: 20 DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
D V++L+ G +P + W G +PLH+AA+ LL+ G S +A + TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 79 ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
A EGHA +V +LL A+ N + +T LH + H V ++LIK+G V ++
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPES 170
T ++ GN L + L +Q+Q + N ++
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKT 731
Score = 83.6 bits (205), Expect = 3e-16
Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 23/243 (9%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AAR+G D+ + NG T + G + LHLA++ GH LL +
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
+ TK T LH+AA G +V L+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
++ GA+ + ++ T +++ G+E++ L IA +N
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 164 -INTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAVQFGNSST 221
+ N +PD ++ TP I +N+ L+ + +S T + G++ + +
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 222 SVL 224
+V+
Sbjct: 251 NVI 253
Score = 80.5 bits (197), Expect = 2e-15
Identities = 44/135 (32%), Positives = 75/135 (55%), Gaps = 1/135 (0%)
Query: 23 RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
++L+ GA T G +PLH+A++ G+ +LL G + +TK + TPLH AA
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 82 GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
GH I E+LL HGA + AK ++ +H A + +H + V LL++Y A++ + T
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 142 DISIDNGNEDLAEIL 156
++ G+ +A++L
Sbjct: 343 HVAAHCGHHRVAKVL 357
Score = 80.5 bits (197), Expect = 2e-15
Identities = 63/198 (31%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AA+ D VR+L+ A T D L +PLH+AA GH+ +VLL G ++R
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + H ++E+LLK GA ++A +T LH A+ H +V+ L++ GA
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
+ + +T ++ G+ ++A+ L +QN+ N ++ D T +H A IG
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483
Query: 189 GVVNLTGLVSSENSSKAT 206
+V L L ++ N + AT
Sbjct: 484 NMVKLL-LENNANPNLAT 500
Score = 78.6 bits (192), Expect = 8e-15
Identities = 56/162 (34%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G IL+ +GAP G SP+H+AAQ H +LL+ D T
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA GH + +VLL GA N++ + T LH A + NH V+ELL+K GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP 171
++ T ++ G+ + + L + A N N E+P
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440
Score = 73.6 bits (179), Expect = 3e-13
Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 13/202 (6%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A+R G VR+L+ GA T +PLH AA+ GH +E+LL G A+TK
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+P+HMAA H V +LL++ A+++ + +T LH A H V ++L+ GA +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG-- 189
+++ T I+ + + E+L + T S D VT TP + G
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL-------LKTG-ASIDAVTESGLTPLHVASFMGHL 417
Query: 190 --VVNLTGLVSSENSSKATDET 209
V NL +S N S ET
Sbjct: 418 PIVKNLLQRGASPNVSNVKVET 439
Score = 72.4 bits (176), Expect = 6e-13
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)
Query: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
+L +P ++ +PLH+AA+ GH + LL+ +A+ K D+TPLH AA GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 84 ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
++V++LL++ A+ N T LH A H E V L++ A +K T +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
+ G +AE+L + A N N +P V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 71.6 bits (174), Expect = 1e-12
Identities = 42/134 (31%), Positives = 71/134 (52%), Gaps = 5/134 (3%)
Query: 7 GKKLLEAAR-AGQDDEVR----ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
GK L A A ++D+ R +L + P G +PLH+AA Y + + ++LL G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 62 VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
S + + TPLH+A+ G+ +V +LL GA + K ++T LH A + H + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 122 LLIKYGADVHTQSK 135
+L+ +GA + ++K
Sbjct: 290 ILLDHGAPIQAKTK 303
Score = 71.6 bits (174), Expect = 1e-12
Identities = 64/244 (26%), Positives = 101/244 (41%), Gaps = 11/244 (4%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
+S V + L AARAG + + L+ N A +PLH AA+ GH + ++LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+ + T TPLH+AA EGH V LL+ A T LH A ++ V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
ELL++ A + K T +++ + N D+ ++L SP + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603
Query: 180 TPQFIIGPGGVVNLT-GLVSSENSSKATDETGVSAVQF-GNSSTSVLATLAALAEASAPL 237
TP I V + L+ S+ A GV+ + + + L +A+ L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 238 SNSS 241
N S
Sbjct: 664 GNKS 667
Score = 67.0 bits (162), Expect = 2e-11
Identities = 75/334 (22%), Positives = 143/334 (42%), Gaps = 34/334 (10%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G+ +L+ A P G +PLH+A + + ++LL G S +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + + LL++G NA+ + +T LH A + H E+V LL+ A+ +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+K T + G+ +A++L +++ + D T TP + G +
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVL---IKHGVMV-----DATTRMGYTPLHVASHYGNI 714
Query: 192 NLTG-LVSSENSSKATDETGVS----AVQFGNSSTSVLATLAALAEASAPLSNSSETPVV 246
L L+ + A + G S A Q G+ T ++ L + +S+ TP+
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTLLLKNGASPNEVSSDGTTPLA 772
Query: 247 ATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH--SIPTSGIGQPIIVTMPDG 304
+ + D +V+T T + + + H S P + + + + V+ +G
Sbjct: 773 IAKRLGYISVTDVL----------KVVTDETSFVLVSDKHRMSFPET-VDEILDVSEDEG 821
Query: 305 QQVLTVPA-----TDIAEETVISEEPPAKRQCIE 333
+++++ A D+ EE + + P Q +E
Sbjct: 822 EELISFKAERRDSRDVDEEKELLDFVPKLDQVVE 855
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/115 (33%), Positives = 62/115 (53%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
LH+AA+ T VLL+ + D +K TPLH+AA + ++ ++LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+T LH A+ + +V LL+ GA + T++K T + NG+ ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 58.5 bits (140), Expect = 9e-09
Identities = 49/174 (28%), Positives = 75/174 (43%), Gaps = 30/174 (17%)
Query: 13 AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA AGQD+ VR L+ GA G +PL++AAQ H + LL G +++ T+
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 72 RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
TPL +A +GH ++V L+ +G D N + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
T LH A + + V +LL+ GA V+ + T I+ GN + +L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 92.0 bits (227), Expect = 7e-19
Identities = 53/154 (34%), Positives = 81/154 (52%)
Query: 6 LGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRD 65
L ++LL AA GQ + V L+ GA G +PLHLAA GH ++LL+AG D
Sbjct: 10 LSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLD 69
Query: 66 ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
+ D+T LH A G+ I+ L+ G ++ +D TALH A+ H + +LL+K
Sbjct: 70 VQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK 129
Query: 126 YGADVHTQSKFCKTAFDISIDNGNEDLAEILQIA 159
GA+V ++K TA ++ N + +L +A
Sbjct: 130 AGANVLAKNKAGNTALHLACQNSHSQSTRVLLLA 163
Score = 76.3 bits (186), Expect = 4e-14
Identities = 51/153 (33%), Positives = 78/153 (50%), Gaps = 1/153 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAP-FTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L EA+ G ++L+ GA + G + LHLA Q H +T VLL AG D +
Sbjct: 112 LHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKN 171
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
T LH+AA H SI+ +LL V+ K+ TALH A NH++V ++L++ GA
Sbjct: 172 NAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGA 231
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQ 161
D + +T + + + N ++A +L A Q
Sbjct: 232 DTTIVNNAGQTPLETARYHNNPEVALLLTKAPQ 264
Score = 68.2 bits (165), Expect = 1e-11
Identities = 46/126 (36%), Positives = 67/126 (53%), Gaps = 1/126 (0%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
L +AA G L+ G +R A TK RTPLH+AA++GH +V++LLK G D++ +D
Sbjct: 14 LLVAAYKGQTENVVQLINKG-ARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQ 161
TALH AT + E++ LI G + Q K TA + +G A++L A
Sbjct: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
Query: 162 NQINTN 167
N + N
Sbjct: 133 NVLAKN 138
Score = 65.5 bits (158), Expect = 7e-11
Identities = 35/119 (29%), Positives = 63/119 (52%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G + LH A+ +G + ++L++AG + A+ K T LH+A H+ VLL G+
Sbjct: 108 GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 167
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+ K+ T LH A +NH ++ LL+ VH +++ TA ++ ++ +A+IL
Sbjct: 168 DLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKIL 226
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 91.3 bits (225), Expect = 1e-18
Identities = 55/153 (35%), Positives = 83/153 (54%), Gaps = 1/153 (0%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AARAG D+V + G T + G + LHLAA+ GH + LL G S
Sbjct: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
D+ TK T LH+A+ G A +V+VL+K GA++NA+ T L+ A + NH +VV+ L
Sbjct: 69 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
++ GA+ T ++ T +++ G+ IL
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161
Score = 82.0 bits (201), Expect = 7e-16
Identities = 62/213 (29%), Positives = 100/213 (46%), Gaps = 12/213 (5%)
Query: 24 ILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
+L+ GA P T G +PLH+AA+ LL G + TK TPLH+A+ EG
Sbjct: 593 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 652
Query: 83 HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
H +V +LL GA+++ +T+LH A + + V ++L K+GAD +K T
Sbjct: 653 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLI 712
Query: 143 ISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPGGVVNLTGLVSSEN 201
++ GN + L ++ N N ++ + T +H A Q G ++N+ L+
Sbjct: 713 VACHYGNVKMVNFL---LKQGANVNAKTKNGYTPLHQAAQQ---GHTHIINV--LLQHGA 764
Query: 202 SSKATDETGVSAVQFGN--SSTSVLATLAALAE 232
AT G +A+ SV+ TL + E
Sbjct: 765 KPNATTANGNTALAIAKRLGYISVVDTLKVVTE 797
Score = 81.3 bits (199), Expect = 1e-15
Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 1/155 (0%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A++ G D V +L+ GA + G + LHLAAQ + ++L + G +DA TK+
Sbjct: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 707
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL +A G+ +V LLK GA+VNAK T LH A + H ++ +L+++GA +
Sbjct: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 767
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
+ TA I+ G + + L++ + T
Sbjct: 768 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 802
Score = 80.5 bits (197), Expect = 2e-15
Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 1/145 (0%)
Query: 13 AARAGQDDEVRILMAN-GAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G D ++L+ A + G +PLH+AA Y + +LL G S A K
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + I LL +GA+ N +T LH A++ H ++V LL+ GA++H
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
+K T+ ++ ++A+IL
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADIL 693
Score = 77.8 bits (190), Expect = 1e-14
Identities = 57/186 (30%), Positives = 93/186 (50%), Gaps = 9/186 (4%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ A P G +PLH+A + E+L++ G S A T+
Sbjct: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TP+H+AA GH +IV +LL++GA + ++ TALH A EVV L++ GA V
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+++ +T I+ G EI+Q+ +Q+ + PD T + TP I G V
Sbjct: 471 ARAREEQTPLHIASRLGK---TEIVQLLLQHMAH-----PDAATTNGYTPLHISAREGQV 522
Query: 192 NLTGLV 197
++ ++
Sbjct: 523 DVASVL 528
Score = 75.9 bits (185), Expect = 5e-14
Identities = 37/98 (37%), Positives = 60/98 (61%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +PLH+AA YG+ + +LL G + D + TPLH+A+ G+ ++V++LL G +
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSK 135
+AK +T LH A H +VVELL++ GA + ++K
Sbjct: 272 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309
Score = 75.9 bits (185), Expect = 5e-14
Identities = 74/284 (26%), Positives = 125/284 (44%), Gaps = 28/284 (9%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + V +L+ NGA P T+ G + LH+AA+ G LLR G DAR + +
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+TPLH+A+ G IV++LL+H A +A T LH + +V +L++ GA
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
+K T ++ G+ D+A++L + A + N +P V H + +
Sbjct: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL---- 592
Query: 190 VVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATE 249
L+ S AT + G + + + A + AS L+ +ET +V +
Sbjct: 593 -----LLLEKGASPHATAKNGYTPLH-------IAAKKNQMQIASTLLNYGAETNIVTKQ 640
Query: 250 EVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGI 293
V + G ++T++ D + N+H SG+
Sbjct: 641 GVT-------PLHLASQEGHTDMVTLLLD--KGANIHMSTKSGL 675
Score = 75.5 bits (184), Expect = 7e-14
Identities = 60/226 (26%), Positives = 108/226 (47%), Gaps = 10/226 (4%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + +L+ GA T G +PLH+A++ G+ + ++LL G DA+T+
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH AA GH +VE+LL+ GA + A+ ++ LH A + +H E V+ L+++ A V
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+ TA ++ G+ + ++L N P+ ++ TP I +
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKRAN--------PNARALNGFTPLHIACKKNRI 390
Query: 192 NLTGLVSSENSS-KATDETGVSAVQFGNSSTSVLATLAALAEASAP 236
+ L+ +S +A E+G++ + + L L ++P
Sbjct: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436
Score = 61.6 bits (148), Expect = 1e-09
Identities = 56/206 (27%), Positives = 96/206 (46%), Gaps = 13/206 (6%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G V+ L+ G+ + G + LH+A+ G +VL++ G + +A+++
Sbjct: 50 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL+MAA E H +V+ LL++GA+ + T L A + H + V +L+ +
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----END 165
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESP---DTVTIHAATPQFIIGPG 188
T+ K A I+ + A +L +QN N + +S + T TP I
Sbjct: 166 TKGKVRLPALHIAARKDDTKSAALL---LQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 222
Query: 189 GVVNLTGLVSSENSSKATDETGVSAV 214
G VN+ L+ N A D T + +
Sbjct: 223 GNVNVATLLL--NRGAAVDFTARNGI 246
Score = 55.8 bits (133), Expect = 6e-08
Identities = 42/155 (27%), Positives = 78/155 (50%), Gaps = 11/155 (7%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L A + G + V IL+ N T + LH+AA+ + +LL+ + D ++K
Sbjct: 146 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 202
Query: 70 --VDRT------PLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
V+RT PLH+AA G+ ++ +LL GA V+ +T LH A++ + +V+
Sbjct: 203 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262
Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
LL+ G + +++ T + +G++ + E+L
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 91.3 bits (225), Expect = 1e-18
Identities = 55/153 (35%), Positives = 83/153 (54%), Gaps = 1/153 (0%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AARAG D+V + G T + G + LHLAA+ GH + LL G S
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
D+ TK T LH+A+ G A +V+VL+K GA++NA+ T L+ A + NH +VV+ L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
++ GA+ T ++ T +++ G+ IL
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 82.0 bits (201), Expect = 7e-16
Identities = 62/213 (29%), Positives = 100/213 (46%), Gaps = 12/213 (5%)
Query: 24 ILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
+L+ GA P T G +PLH+AA+ LL G + TK TPLH+A+ EG
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673
Query: 83 HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
H +V +LL GA+++ +T+LH A + + V ++L K+GAD +K T
Sbjct: 674 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLI 733
Query: 143 ISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPGGVVNLTGLVSSEN 201
++ GN + L ++ N N ++ + T +H A Q G ++N+ L+
Sbjct: 734 VACHYGNVKMVNFL---LKQGANVNAKTKNGYTPLHQAAQQ---GHTHIINV--LLQHGA 785
Query: 202 SSKATDETGVSAVQFGN--SSTSVLATLAALAE 232
AT G +A+ SV+ TL + E
Sbjct: 786 KPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818
Score = 81.3 bits (199), Expect = 1e-15
Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 1/155 (0%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A++ G D V +L+ GA + G + LHLAAQ + ++L + G +DA TK+
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL +A G+ +V LLK GA+VNAK T LH A + H ++ +L+++GA +
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
+ TA I+ G + + L++ + T
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 823
Score = 80.5 bits (197), Expect = 2e-15
Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 1/145 (0%)
Query: 13 AARAGQDDEVRILMAN-GAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G D ++L+ A + G +PLH+AA Y + +LL G S A K
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + I LL +GA+ N +T LH A++ H ++V LL+ GA++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
+K T+ ++ ++A+IL
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 77.8 bits (190), Expect = 1e-14
Identities = 57/186 (30%), Positives = 93/186 (50%), Gaps = 9/186 (4%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ A P G +PLH+A + E+L++ G S A T+
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TP+H+AA GH +IV +LL++GA + ++ TALH A EVV L++ GA V
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+++ +T I+ G EI+Q+ +Q+ + PD T + TP I G V
Sbjct: 492 ARAREEQTPLHIASRLGK---TEIVQLLLQHMAH-----PDAATTNGYTPLHISAREGQV 543
Query: 192 NLTGLV 197
++ ++
Sbjct: 544 DVASVL 549
Score = 75.9 bits (185), Expect = 5e-14
Identities = 37/98 (37%), Positives = 60/98 (61%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +PLH+AA YG+ + +LL G + D + TPLH+A+ G+ ++V++LL G +
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSK 135
+AK +T LH A H +VVELL++ GA + ++K
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Score = 75.9 bits (185), Expect = 5e-14
Identities = 74/284 (26%), Positives = 125/284 (44%), Gaps = 28/284 (9%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + V +L+ NGA P T+ G + LH+AA+ G LLR G DAR + +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+TPLH+A+ G IV++LL+H A +A T LH + +V +L++ GA
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
+K T ++ G+ D+A++L + A + N +P V H + +
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL---- 613
Query: 190 VVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATE 249
L+ S AT + G + + + A + AS L+ +ET +V +
Sbjct: 614 -----LLLEKGASPHATAKNGYTPLH-------IAAKKNQMQIASTLLNYGAETNIVTKQ 661
Query: 250 EVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGI 293
V + G ++T++ D + N+H SG+
Sbjct: 662 GVT-------PLHLASQEGHTDMVTLLLD--KGANIHMSTKSGL 696
Score = 75.5 bits (184), Expect = 7e-14
Identities = 60/226 (26%), Positives = 108/226 (47%), Gaps = 10/226 (4%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + +L+ GA T G +PLH+A++ G+ + ++LL G DA+T+
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH AA GH +VE+LL+ GA + A+ ++ LH A + +H E V+ L+++ A V
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+ TA ++ G+ + ++L N P+ ++ TP I +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRAN--------PNARALNGFTPLHIACKKNRI 411
Query: 192 NLTGLVSSENSS-KATDETGVSAVQFGNSSTSVLATLAALAEASAP 236
+ L+ +S +A E+G++ + + L L ++P
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Score = 61.6 bits (148), Expect = 1e-09
Identities = 56/206 (27%), Positives = 96/206 (46%), Gaps = 13/206 (6%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G V+ L+ G+ + G + LH+A+ G +VL++ G + +A+++
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL+MAA E H +V+ LL++GA+ + T L A + H + V +L+ +
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----END 186
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESP---DTVTIHAATPQFIIGPG 188
T+ K A I+ + A +L +QN N + +S + T TP I
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALL---LQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 189 GVVNLTGLVSSENSSKATDETGVSAV 214
G VN+ L+ N A D T + +
Sbjct: 244 GNVNVATLLL--NRGAAVDFTARNGI 267
Score = 55.8 bits (133), Expect = 6e-08
Identities = 42/155 (27%), Positives = 78/155 (50%), Gaps = 11/155 (7%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L A + G + V IL+ N T + LH+AA+ + +LL+ + D ++K
Sbjct: 167 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223
Query: 70 --VDRT------PLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
V+RT PLH+AA G+ ++ +LL GA V+ +T LH A++ + +V+
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
LL+ G + +++ T + +G++ + E+L
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 91.3 bits (225), Expect = 1e-18
Identities = 55/153 (35%), Positives = 83/153 (54%), Gaps = 1/153 (0%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AARAG D+V + G T + G + LHLAA+ GH + LL G S
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
D+ TK T LH+A+ G A +V+VL+K GA++NA+ T L+ A + NH +VV+ L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
++ GA+ T ++ T +++ G+ IL
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 82.0 bits (201), Expect = 7e-16
Identities = 62/213 (29%), Positives = 100/213 (46%), Gaps = 12/213 (5%)
Query: 24 ILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
+L+ GA P T G +PLH+AA+ LL G + TK TPLH+A+ EG
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673
Query: 83 HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
H +V +LL GA+++ +T+LH A + + V ++L K+GAD +K T
Sbjct: 674 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLI 733
Query: 143 ISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPGGVVNLTGLVSSEN 201
++ GN + L ++ N N ++ + T +H A Q G ++N+ L+
Sbjct: 734 VACHYGNVKMVNFL---LKQGANVNAKTKNGYTPLHQAAQQ---GHTHIINV--LLQHGA 785
Query: 202 SSKATDETGVSAVQFGN--SSTSVLATLAALAE 232
AT G +A+ SV+ TL + E
Sbjct: 786 KPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818
Score = 81.3 bits (199), Expect = 1e-15
Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 1/155 (0%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A++ G D V +L+ GA + G + LHLAAQ + ++L + G +DA TK+
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL +A G+ +V LLK GA+VNAK T LH A + H ++ +L+++GA +
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
+ TA I+ G + + L++ + T
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 823
Score = 80.5 bits (197), Expect = 2e-15
Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 1/145 (0%)
Query: 13 AARAGQDDEVRILMAN-GAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G D ++L+ A + G +PLH+AA Y + +LL G S A K
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + I LL +GA+ N +T LH A++ H ++V LL+ GA++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
+K T+ ++ ++A+IL
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 77.8 bits (190), Expect = 1e-14
Identities = 57/186 (30%), Positives = 93/186 (50%), Gaps = 9/186 (4%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ A P G +PLH+A + E+L++ G S A T+
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TP+H+AA GH +IV +LL++GA + ++ TALH A EVV L++ GA V
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+++ +T I+ G EI+Q+ +Q+ + PD T + TP I G V
Sbjct: 492 ARAREEQTPLHIASRLGK---TEIVQLLLQHMAH-----PDAATTNGYTPLHISAREGQV 543
Query: 192 NLTGLV 197
++ ++
Sbjct: 544 DVASVL 549
Score = 75.9 bits (185), Expect = 5e-14
Identities = 37/98 (37%), Positives = 60/98 (61%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +PLH+AA YG+ + +LL G + D + TPLH+A+ G+ ++V++LL G +
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSK 135
+AK +T LH A H +VVELL++ GA + ++K
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Score = 75.9 bits (185), Expect = 5e-14
Identities = 74/284 (26%), Positives = 125/284 (44%), Gaps = 28/284 (9%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + V +L+ NGA P T+ G + LH+AA+ G LLR G DAR + +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+TPLH+A+ G IV++LL+H A +A T LH + +V +L++ GA
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
+K T ++ G+ D+A++L + A + N +P V H + +
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL---- 613
Query: 190 VVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATE 249
L+ S AT + G + + + A + AS L+ +ET +V +
Sbjct: 614 -----LLLEKGASPHATAKNGYTPLH-------IAAKKNQMQIASTLLNYGAETNIVTKQ 661
Query: 250 EVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGI 293
V + G ++T++ D + N+H SG+
Sbjct: 662 GVT-------PLHLASQEGHTDMVTLLLD--KGANIHMSTKSGL 696
Score = 75.5 bits (184), Expect = 7e-14
Identities = 60/226 (26%), Positives = 108/226 (47%), Gaps = 10/226 (4%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + +L+ GA T G +PLH+A++ G+ + ++LL G DA+T+
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH AA GH +VE+LL+ GA + A+ ++ LH A + +H E V+ L+++ A V
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+ TA ++ G+ + ++L N P+ ++ TP I +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRAN--------PNARALNGFTPLHIACKKNRI 411
Query: 192 NLTGLVSSENSS-KATDETGVSAVQFGNSSTSVLATLAALAEASAP 236
+ L+ +S +A E+G++ + + L L ++P
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Score = 61.6 bits (148), Expect = 1e-09
Identities = 56/206 (27%), Positives = 96/206 (46%), Gaps = 13/206 (6%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G V+ L+ G+ + G + LH+A+ G +VL++ G + +A+++
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL+MAA E H +V+ LL++GA+ + T L A + H + V +L+ +
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----END 186
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESP---DTVTIHAATPQFIIGPG 188
T+ K A I+ + A +L +QN N + +S + T TP I
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALL---LQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 189 GVVNLTGLVSSENSSKATDETGVSAV 214
G VN+ L+ N A D T + +
Sbjct: 244 GNVNVATLLL--NRGAAVDFTARNGI 267
Score = 55.8 bits (133), Expect = 6e-08
Identities = 42/155 (27%), Positives = 78/155 (50%), Gaps = 11/155 (7%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L A + G + V IL+ N T + LH+AA+ + +LL+ + D ++K
Sbjct: 167 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223
Query: 70 --VDRT------PLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
V+RT PLH+AA G+ ++ +LL GA V+ +T LH A++ + +V+
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
LL+ G + +++ T + +G++ + E+L
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 84.3 bits (207), Expect = 2e-16
Identities = 53/141 (37%), Positives = 73/141 (51%), Gaps = 1/141 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
LL AA AG+ +R L+A GA D G + L LAA G EVLL G R
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
+ R+ LH AA+ GH V++L+ GA+V+A+D L +T LH A+ H EV L+ GA
Sbjct: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGA 326
Query: 129 DVHTQSKFCKTAFDISIDNGN 149
V KT ++ + G+
Sbjct: 327 QVDATGWLRKTPLHLAAERGH 347
Score = 84.3 bits (207), Expect = 2e-16
Identities = 48/129 (37%), Positives = 68/129 (52%), Gaps = 1/129 (0%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G+ ++ +L+ +GA P D G S LH AA GH ++L+ G DAR +
Sbjct: 243 AAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLG 302
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH A+ EGH + LL GA V+A L+ T LH A E H V LL+ GA
Sbjct: 303 LTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPT 362
Query: 132 TQSKFCKTA 140
++++ + A
Sbjct: 363 LRTQWAEVA 371
Score = 70.1 bits (170), Expect = 3e-12
Identities = 37/78 (47%), Positives = 45/78 (57%)
Query: 57 LLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNH 116
LLR G S + R RTPLH+A GHA +V +LL+ GA V A D TALH A H H
Sbjct: 60 LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
Query: 117 QEVVELLIKYGADVHTQS 134
V ELL++ GA +S
Sbjct: 120 SRVAELLLQRGASAAARS 137
Score = 68.6 bits (166), Expect = 9e-12
Identities = 47/121 (38%), Positives = 59/121 (48%), Gaps = 5/121 (4%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A G VR+L+ GAP D G + LH AA +GH E+LL+ G S AR+
Sbjct: 81 AVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTG 140
Query: 72 RTPLHMAASEGHASIVEVLLKHG----ADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
TPLH AA+ GH + LL+ A A+D TA HWA V+ELL G
Sbjct: 141 LTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGG 200
Query: 128 A 128
A
Sbjct: 201 A 201
Score = 67.4 bits (163), Expect = 2e-11
Identities = 42/117 (35%), Positives = 57/117 (48%), Gaps = 1/117 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
LL+A G V L+ GA D G +PLHLA GH +LL+ G A
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
+ RT LH AA GH+ + E+LL+ GA A+ +T LHWA H + L++
Sbjct: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLE 161
Score = 60.5 bits (145), Expect = 2e-09
Identities = 46/144 (31%), Positives = 65/144 (45%), Gaps = 6/144 (4%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR 72
AA G+ + +L A GA L +AA G + LL G DAR
Sbjct: 184 AAAGGRLAVLELLAAGGAGLD------GALLVAAAAGRGAALRFLLARGARVDARDGAGA 237
Query: 73 TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
T L +AA+ G + +EVLL HGAD +D +ALH A H V+LL+ GA+V
Sbjct: 238 TALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDA 297
Query: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
+ T + G+ ++A L
Sbjct: 298 RDTLGLTPLHHASREGHVEVAGCL 321
Score = 44.7 bits (104), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%)
Query: 75 LHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQS 134
L A G A +V LL+ GA V +D T LH A H +V LL++ GA V
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
Query: 135 KFCKTAFDISIDNGNEDLAEIL 156
+ +TA + +G+ +AE+L
Sbjct: 105 RAGRTALHEAAWHGHSRVAELL 126
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 84.3 bits (207), Expect = 2e-16
Identities = 60/188 (31%), Positives = 91/188 (48%), Gaps = 6/188 (3%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ A P G +PLH+A + E+LL+ G S A T+
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TP+H+AA GH +IV L+ HGA N ++ TALH A EVV L++ GA V
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTI---HAATPQFIIG 186
++K +T IS G D+ + L Q A N T+ +P ++ H F++
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLD 553
Query: 187 PGGVVNLT 194
G +++T
Sbjct: 554 HGASLSIT 561
Score = 84.0 bits (206), Expect = 2e-16
Identities = 50/153 (32%), Positives = 80/153 (52%), Gaps = 1/153 (0%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AARAG ++ + NG + G + LHLA++ GH LL+ +
Sbjct: 40 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 99
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
DA TK T LH+A+ G A +V+VL+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+ GA ++ T +++ G++ + +L
Sbjct: 160 LDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Score = 84.0 bits (206), Expect = 2e-16
Identities = 52/155 (33%), Positives = 79/155 (50%), Gaps = 1/155 (0%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G D V +L+ A ++ G +PLHLAAQ + EVL+ G DA+TK+
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ G+ IV LL+H A VNAK T LH A + H ++ +L++ A +
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
+ TA I+ G + + L+I + + T
Sbjct: 791 ELTVNGNTALGIARRLGYISVVDTLKIVTEETMTT 825
Score = 81.6 bits (200), Expect = 1e-15
Identities = 71/288 (24%), Positives = 127/288 (44%), Gaps = 28/288 (9%)
Query: 24 ILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
+L+ GA P G +PLH+AA+ LL G +A T+ +H+AA EG
Sbjct: 616 LLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEG 675
Query: 83 HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
H +V +LL A+VN + +T LH A + + V E+L+ GA V Q+K T
Sbjct: 676 HVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLH 735
Query: 143 ISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPGGVVNLTGLVSSEN 201
+ GN +I+ +Q+ N ++ + T +H A Q G ++ ++ N
Sbjct: 736 VGCHYGN---IKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQ------GHTHIINVLLQNN 786
Query: 202 SSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAI 261
+S +E V+ GN++ + L ++ +T + TEE +T +V
Sbjct: 787 AS--PNELTVN----GNTALGIARRLGYISVV--------DTLKIVTEETMTTTTVTEKH 832
Query: 262 QQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLT 309
+ V +V+ + D ++ N + + G I + +G+ +T
Sbjct: 833 KMNVPETMNEVLDMSDDEVRKANAPEMLSDG---EYISDVEEGEDAMT 877
Score = 80.5 bits (197), Expect = 2e-15
Identities = 50/145 (34%), Positives = 77/145 (53%), Gaps = 1/145 (0%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + V LM +GA P TT+ G + LH+AA+ G L++ G +A+ K D
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+TPLH++A G A IV+ LL+ GA NA T LH + H++V L+ +GA +
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
+K T ++ G ++A +L
Sbjct: 560 ITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 80.5 bits (197), Expect = 2e-15
Identities = 65/232 (28%), Positives = 102/232 (43%), Gaps = 11/232 (4%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR+GQ + VR L+ +GA +PLH++A+ G + LL+ G S +A T
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH++A EGH + LL HGA ++ T LH A ++ EV LL++ A
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
K T ++ N+ +A +L SP + TP I +
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLL--------DQGASPHAAAKNGYTPLHIAAKKNQM 644
Query: 192 NL-TGLVSSENSSKATDETGVSAVQFGNSSTSV-LATLAALAEASAPLSNSS 241
++ T L+ + A G+++V V + +L A+ LSN S
Sbjct: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS 696
Score = 80.1 bits (196), Expect = 3e-15
Identities = 59/199 (29%), Positives = 97/199 (48%), Gaps = 12/199 (6%)
Query: 14 ARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR 72
AR+G + V +L+ AP + G SPLH+A Q H + ++LL+ V D T
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL 368
Query: 73 TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
T LH+AA GH + +VLL A+ NAK + T LH A + N +V+ELL+K+GA +
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 133 QSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG--- 189
++ T ++ G+ ++ +Q+ + SP+T + T + G
Sbjct: 429 VTESGLTPIHVAAFMGHVNIV--------SQLMHHGASPNTTNVRGETALHMAARSGQAE 480
Query: 190 VVNLTGLVSSENSSKATDE 208
VV ++ +KA D+
Sbjct: 481 VVRYLVQDGAQVEAKAKDD 499
Score = 77.0 bits (188), Expect = 2e-14
Identities = 43/143 (30%), Positives = 80/143 (55%), Gaps = 4/143 (2%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +PLH+AA YG+ + +LL + D + D TPLH+A+ G+A++V++LL GA +
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
+AK +T LH H++VVE+L+ A + +++K + ++ D +Q
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQG---DHLNCVQ 351
Query: 158 IAMQNQINTNPESPDTVT-IHAA 179
+ +Q+ + + + D +T +H A
Sbjct: 352 LLLQHNVPVDDVTNDYLTALHVA 374
Score = 76.6 bits (187), Expect = 3e-14
Identities = 46/145 (31%), Positives = 74/145 (51%), Gaps = 1/145 (0%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G+ + +L+ A P G +PLH+AA Y + +LL G S A K
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + I LL++GAD NA + ++H A + H ++V LL+ A+V+
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
+K T ++ ++AE+L
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVL 716
Score = 75.5 bits (184), Expect = 7e-14
Identities = 48/176 (27%), Positives = 89/176 (50%), Gaps = 9/176 (5%)
Query: 40 SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNA 99
+PLH+A++ G+ + ++LL G DA+T+ TPLH A GH +VE+LL A + +
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329
Query: 100 KDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIA 159
K ++ LH AT+ +H V+LL+++ V + TA ++ G+ +A++L
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 160 MQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAV 214
N P+ ++ TP I + + L+ +S +A E+G++ +
Sbjct: 390 KAN--------PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPI 437
Score = 68.9 bits (167), Expect = 7e-12
Identities = 66/261 (25%), Positives = 113/261 (43%), Gaps = 18/261 (6%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
A++ G + V++L+ GA T D G +PLH A+ GH E+LL ++TK
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRD--GLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
+PLHMA H + V++LL+H V+ +TALH A H +V ++L+ A+
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
+ ++ T I+ + E+L + S VT TP + G
Sbjct: 393 PNAKALNGFTPLHIACKKNRIKVMELLL--------KHGASIQAVTESGLTPIHVAAFMG 444
Query: 190 VVNLTGLV----SSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPV 245
VN+ + +S N++ ET + + V + A+ A + +TP+
Sbjct: 445 HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK-AKDDQTPL 503
Query: 246 VATEEVVTAESVDGAIQQVVS 266
+ + A+ V +QQ S
Sbjct: 504 HISARLGKADIVQQLLQQGAS 524
Score = 60.5 bits (145), Expect = 2e-09
Identities = 41/147 (27%), Positives = 72/147 (48%), Gaps = 3/147 (2%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L A + G D V +L+ N T + LH+AA+ +LL+ + D +K
Sbjct: 177 LAVALQQGHDQVVSLLLEND---TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK 233
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+AA G+ ++ +LL A V+ +T LH A++ + +V+LL+ GA
Sbjct: 234 SGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAK 293
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEIL 156
+ +++ T +G+E + E+L
Sbjct: 294 IDAKTRDGLTPLHCGARSGHEQVVEML 320
Score = 59.7 bits (143), Expect = 4e-09
Identities = 51/172 (29%), Positives = 80/172 (46%), Gaps = 14/172 (8%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G + LH+A+ G +VL+ G + +A+++ TPL+MAA E H +V+ LL +GA
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
+ T L A + H +VV LL+ + T+ K A I+ + A +L
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLL----ENDTKGKVRLPALHIAARKDDTKAAALL- 221
Query: 158 IAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSSKATDET 209
+QN N + ES TP I G +N+ L+ N + A D T
Sbjct: 222 --LQNDNNADVESKS-----GFTPLHIAAHYGNINVATLLL--NRAAAVDFT 264
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 84.0 bits (206), Expect = 2e-16
Identities = 54/147 (36%), Positives = 78/147 (53%), Gaps = 3/147 (2%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGTS-PLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G+ D + +L+ +GA + PLHLA Q GH+ + LL + + +
Sbjct: 751 AALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSG 810
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL A S GH +V +LL+HGA +NA + TALH A H VVELL+ +GA V
Sbjct: 811 NTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
+K +TA D + N + E+LQ+
Sbjct: 871 VLNKRQRTAVDCA--EQNSKIMELLQV 895
Score = 74.7 bits (182), Expect = 1e-13
Identities = 40/119 (33%), Positives = 64/119 (53%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G+SPLH+AA +G +LL+ G + AR PLH+A +GH +V+ LL A
Sbjct: 744 GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 803
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
N KD+ T L +A H E+V LL+++GA ++ + TA ++ + + E+L
Sbjct: 804 NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELL 862
Score = 72.8 bits (177), Expect = 5e-13
Identities = 55/201 (27%), Positives = 96/201 (47%), Gaps = 11/201 (5%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA GQ + +L++ GA TD+ G +PLHLA Q G+ S T +LL S + +
Sbjct: 470 AAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNG 529
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKM---TALHWATEHNHQEVVELLIKYGA 128
TPLH+A + GH V+ L+ + + D+ T LH A +Q V+E L++ GA
Sbjct: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPG 188
Q++ +T ++++ + E ++ + + + E+P +PQ +
Sbjct: 590 STEIQNRLKETPLKCALNSKILSVMEAYHLSFERR-QKSSEAP------VQSPQRSVDSI 642
Query: 189 GVVNLTGLVSSENSSKATDET 209
+ T SS ++S +ET
Sbjct: 643 SQESSTSSFSSMSASSRQEET 663
Score = 62.4 bits (150), Expect = 6e-10
Identities = 33/99 (33%), Positives = 53/99 (53%)
Query: 31 PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVL 90
PF+ D G +PLH+AA G S ++L+ G +A TPLH+A +G+ S+ +L
Sbjct: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515
Query: 91 LKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
L + A +D T LH A + H++ V+ L+ Y +
Sbjct: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE 554
Score = 58.9 bits (141), Expect = 7e-09
Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 3/94 (3%)
Query: 63 SRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVEL 122
SRD R TPLH+AA G AS++++L+ GA VNA D T LH A + +Q V L
Sbjct: 458 SRDDR---GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLL 514
Query: 123 LIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
L+ Y A Q T ++ G+ED + L
Sbjct: 515 LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKAL 548
Score = 54.7 bits (130), Expect = 1e-07
Identities = 43/184 (23%), Positives = 84/184 (45%), Gaps = 7/184 (3%)
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+G+ + ++ +PLH+AA G A ++ +LLKHGA+ A++ + LH A + H +V
Sbjct: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
V+ L+ A + + T + G+ +L +L + IN + +T A
Sbjct: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALL-LQHGASINASNNKGNTALHEAV 851
Query: 180 TPQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSN 239
+ + VV L L+ S + ++ +AV ++ ++ L + A L +
Sbjct: 852 IEKHVF----VVEL--LLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDD 905
Query: 240 SSET 243
+ET
Sbjct: 906 VAET 909
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 82.8 bits (203), Expect = 4e-16
Identities = 57/160 (35%), Positives = 78/160 (48%), Gaps = 29/160 (18%)
Query: 37 LGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGAD 96
L +PLH+AA+ GH ST +LL G ++A T T LH+AA GH + V++L++ AD
Sbjct: 636 LAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKAD 695
Query: 97 VNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
V A+ L TALH A H H EVVE L+ ADV ID +E L
Sbjct: 696 VLARGPLNQTALHLAAAHGHSEVVEELV--SADV--------------IDLFDEQGLSAL 739
Query: 157 QIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGL 196
+A Q + HA T + ++ G +NL L
Sbjct: 740 HLAAQGR-------------HAQTVETLLRHGAHINLQSL 766
Score = 80.5 bits (197), Expect = 2e-15
Identities = 56/164 (34%), Positives = 80/164 (48%), Gaps = 16/164 (9%)
Query: 13 AARAGQDDEVRILMANGAPFTTD----WLGTSPLHLAAQYGHYSTTEVLLRA-GVSRDAR 67
A + GQ++ VRIL+ G + WL PLH AA GH ++L + GVS +A+
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWL---PLHYAAWQGHLPIVKLLAKQPGVSVNAQ 600
Query: 68 TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
T RTPLH+AA GH + +L+ +DVN +L T LH A E H LL+ G
Sbjct: 601 TLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG 660
Query: 128 ADVHTQSKFCKTAFDISIDNGN--------EDLAEILQIAMQNQ 163
A + TA ++ NG+ E+ A++L NQ
Sbjct: 661 AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQ 704
Score = 77.4 bits (189), Expect = 2e-14
Identities = 43/119 (36%), Positives = 64/119 (53%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +PLHLAAQ GHY +L+ + + + +TPLH+AA GH S +LL GA
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGK 663
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
A TALH A + H V+LL++ ADV + +TA ++ +G+ ++ E L
Sbjct: 664 EAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL 722
Score = 77.0 bits (188), Expect = 2e-14
Identities = 55/179 (30%), Positives = 90/179 (50%), Gaps = 5/179 (2%)
Query: 4 VDLGKKLLE-AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
+D G LL A AGQ++ + L+ N A P ++ G++PLH+A + E+LL
Sbjct: 435 LDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK 494
Query: 62 VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
+S +A+ + T LH AA G S +LL+ A VN D T +H A +H + +V
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAA 179
+L++ G DV Q K + G+ + ++L A Q ++ N ++ D T +H A
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL--AKQPGVSVNAQTLDGRTPLHLA 611
Score = 32.3 bits (72), Expect = 0.68
Identities = 21/49 (42%), Positives = 24/49 (48%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
AA G + V L++ D G S LHLAAQ H T E LLR G
Sbjct: 710 AAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG 758
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 82.4 bits (202), Expect = 6e-16
Identities = 50/143 (34%), Positives = 77/143 (53%), Gaps = 1/143 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L AA G+ + +L+ +GA + T+ G PL AA+ GH+ +LL G +
Sbjct: 1075 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD 1134
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
K RTPL +AA EGH S VE LL GA +++ D ++AL WA H+ VV+ L++ GA
Sbjct: 1135 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA 1194
Query: 129 DVHTQSKFCKTAFDISIDNGNED 151
+ K +T D++ G+ +
Sbjct: 1195 AIDQTDKNGRTPLDLAAFYGDAE 1217
Score = 60.1 bits (144), Expect = 3e-09
Identities = 40/117 (34%), Positives = 59/117 (50%), Gaps = 1/117 (0%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G VR+L+ G +D G +PL +AA GH ST E LL G + + K
Sbjct: 1111 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1170
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
+ L A +GH ++V+ L++ GA ++ D T L A + E V L++ GA
Sbjct: 1171 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1227
Score = 54.7 bits (130), Expect = 1e-07
Identities = 57/200 (28%), Positives = 84/200 (42%), Gaps = 17/200 (8%)
Query: 6 LGKKLLEAARAGQDDEVRILMA---------NGAPFTTDWLGTSPLHLAAQYGHYSTTEV 56
L + L AA G V+ L+ NG T W G + L AA G E+
Sbjct: 1033 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTD--TLW-GETALTAAAGRGKLEVCEL 1089
Query: 57 LLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNH 116
LL G + + PL AA +GH IV +LL+ G DVN D T L A H
Sbjct: 1090 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1149
Query: 117 QEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP-DT 173
VE L+ GA + + K +A + G+ + + L + A +Q + N +P D
Sbjct: 1150 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1209
Query: 174 VTIH--AATPQFIIGPGGVV 191
+ A T +++ G V+
Sbjct: 1210 AAFYGDAETVLYLVEKGAVI 1229
Score = 51.2 bits (121), Expect = 1e-06
Identities = 40/120 (33%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L+ AA G V L++ GA ++ D G S L A GH + + L+ G + D
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1200
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
K RTPL +AA G A V L++ GA + D M L A + VV L++ GA
Sbjct: 1201 KNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 13/149 (8%)
Query: 36 WLGTSPLHLAAQYG--------HYSTTEVLLRAGVSRDARTKV-DRTPLHMAASE-GHAS 85
W+G S L+A + + +L+ G + + RT+V + P+ S GH
Sbjct: 882 WIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEE 941
Query: 86 IVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISI 145
+V +LL+ GA ++ MTAL +A H ++V LL K G V K + A S
Sbjct: 942 VVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSA 1001
Query: 146 DNGNEDLAEILQIAMQNQINTNPESPDTV 174
G+ D ILQ + + + P P T+
Sbjct: 1002 LRGHGD---ILQYLLTCEWSPGPPQPGTL 1027
Score = 41.6 bits (96), Expect = 0.001
Identities = 30/105 (28%), Positives = 50/105 (47%), Gaps = 3/105 (2%)
Query: 23 RILMANGAP--FTTDWLGTSP-LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAA 79
R+L+ GA + T+ L +P L + + GH +LL G D ++ T L AA
Sbjct: 909 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968
Query: 80 SEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLI 124
+ GH +V +L K G V+ D AL + H ++++ L+
Sbjct: 969 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1013
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 82.4 bits (202), Expect = 6e-16
Identities = 50/143 (34%), Positives = 77/143 (53%), Gaps = 1/143 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L AA G+ + +L+ +GA + T+ G PL AA+ GH+ +LL G +
Sbjct: 1083 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD 1142
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
K RTPL +AA EGH S VE LL GA +++ D ++AL WA H+ VV+ L++ GA
Sbjct: 1143 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA 1202
Query: 129 DVHTQSKFCKTAFDISIDNGNED 151
+ K +T D++ G+ +
Sbjct: 1203 AIDQTDKNGRTPLDLAAFYGDAE 1225
Score = 60.1 bits (144), Expect = 3e-09
Identities = 40/117 (34%), Positives = 59/117 (50%), Gaps = 1/117 (0%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G VR+L+ G +D G +PL +AA GH ST E LL G + + K
Sbjct: 1119 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1178
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
+ L A +GH ++V+ L++ GA ++ D T L A + E V L++ GA
Sbjct: 1179 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1235
Score = 54.7 bits (130), Expect = 1e-07
Identities = 57/200 (28%), Positives = 84/200 (42%), Gaps = 17/200 (8%)
Query: 6 LGKKLLEAARAGQDDEVRILMA---------NGAPFTTDWLGTSPLHLAAQYGHYSTTEV 56
L + L AA G V+ L+ NG T W G + L AA G E+
Sbjct: 1041 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTD--TLW-GETALTAAAGRGKLEVCEL 1097
Query: 57 LLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNH 116
LL G + + PL AA +GH IV +LL+ G DVN D T L A H
Sbjct: 1098 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1157
Query: 117 QEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP-DT 173
VE L+ GA + + K +A + G+ + + L + A +Q + N +P D
Sbjct: 1158 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1217
Query: 174 VTIH--AATPQFIIGPGGVV 191
+ A T +++ G V+
Sbjct: 1218 AAFYGDAETVLYLVEKGAVI 1237
Score = 51.2 bits (121), Expect = 1e-06
Identities = 40/120 (33%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L+ AA G V L++ GA ++ D G S L A GH + + L+ G + D
Sbjct: 1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1208
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
K RTPL +AA G A V L++ GA + D M L A + VV L++ GA
Sbjct: 1209 KNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 13/149 (8%)
Query: 36 WLGTSPLHLAAQYG--------HYSTTEVLLRAGVSRDARTKV-DRTPLHMAASE-GHAS 85
W+G S L+A + + +L+ G + + RT+V + P+ S GH
Sbjct: 890 WIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEE 949
Query: 86 IVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISI 145
+V +LL+ GA ++ MTAL +A H ++V LL K G V K + A S
Sbjct: 950 VVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSA 1009
Query: 146 DNGNEDLAEILQIAMQNQINTNPESPDTV 174
G+ D ILQ + + + P P T+
Sbjct: 1010 LRGHGD---ILQYLLTCEWSPGPPQPGTL 1035
Score = 41.6 bits (96), Expect = 0.001
Identities = 30/105 (28%), Positives = 50/105 (47%), Gaps = 3/105 (2%)
Query: 23 RILMANGAP--FTTDWLGTSP-LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAA 79
R+L+ GA + T+ L +P L + + GH +LL G D ++ T L AA
Sbjct: 917 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976
Query: 80 SEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLI 124
+ GH +V +L K G V+ D AL + H ++++ L+
Sbjct: 977 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1021
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 81.6 bits (200), Expect = 1e-15
Identities = 49/138 (35%), Positives = 73/138 (52%), Gaps = 1/138 (0%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G D ++L + G+ P D +PLH AA +G+YS + L AG + + + +
Sbjct: 452 AARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREG 511
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL A++ G+ IVE L +HGAD+NA D ALH A EV++ L+ G V
Sbjct: 512 ETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVD 571
Query: 132 TQSKFCKTAFDISIDNGN 149
Q + T ++ +GN
Sbjct: 572 YQDRHGNTPLHVACKDGN 589
Score = 75.9 bits (185), Expect = 5e-14
Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 1/134 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G D ++ L N P D G LH+AA+YGH ++L G + + + K +
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE 478
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH AA G+ S+ + L + G +VN K+ T L A+ + ++VE L ++GAD++
Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLN 538
Query: 132 TQSKFCKTAFDISI 145
K A +++
Sbjct: 539 ACDKDGHIALHLAV 552
Score = 66.2 bits (160), Expect = 4e-11
Identities = 42/148 (28%), Positives = 74/148 (50%), Gaps = 1/148 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
LL AA G +++L+ G+ D G++ ++ AA++GH T + L D +
Sbjct: 383 LLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKD 442
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
K LH+AA GHA + ++L G++ N +D + T LH A H + V + L + G
Sbjct: 443 KSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGC 502
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+V+ +++ +T + G D+ E L
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVECL 530
Score = 59.7 bits (143), Expect = 4e-09
Identities = 45/148 (30%), Positives = 67/148 (45%), Gaps = 1/148 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
LL A+ G D V L +GA D G LHLA + + LL G D +
Sbjct: 515 LLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQD 574
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
+ TPLH+A +G+ IV L + +++ + T LH A + +VV L GA
Sbjct: 575 RHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGA 634
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEIL 156
V + KTA D++ +E +A +L
Sbjct: 635 SVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 58.2 bits (139), Expect = 1e-08
Identities = 39/120 (32%), Positives = 54/120 (45%), Gaps = 1/120 (0%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A R Q + ++ L++ G D G +PLH+A + G+ L A + D K
Sbjct: 551 AVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYG 610
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
RTPLH+AA+ G +V L GA V A TA A H+ V LL + D H
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTH 670
Score = 57.0 bits (136), Expect = 3e-08
Identities = 33/119 (27%), Positives = 60/119 (50%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
GT PL +AA G+ ++L++ G D + K ++ AA GH ++ L ++ +
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPL 438
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+ KD ALH A + H +V +LL +G++ + Q K +T + +G +A+ L
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 81.6 bits (200), Expect = 1e-15
Identities = 47/129 (36%), Positives = 67/129 (51%), Gaps = 1/129 (0%)
Query: 45 AAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLK 104
AA G E L G S D + RT LH A+ EGH I+E LL +GA V+ +D L
Sbjct: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
Query: 105 MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQI 164
TA+HWA H EVV+LL +GAD + + K T +++ G ++ E +++ +I
Sbjct: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF-LSLGLEI 273
Query: 165 NTNPESPDT 173
N DT
Sbjct: 274 NARDREGDT 282
Score = 74.3 bits (181), Expect = 2e-13
Identities = 46/135 (34%), Positives = 71/135 (52%), Gaps = 1/135 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L A+ G + + L+ NGA D L + +H A + GH ++L G + R
Sbjct: 185 LHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRD 244
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
K+ TPLH+A G IVE L G ++NA+D TALH A N ++++LL+ +GA
Sbjct: 245 KLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGA 304
Query: 129 DVHTQSKFCKTAFDI 143
D+ T++ KT D+
Sbjct: 305 DMMTKNLAGKTPTDL 319
Score = 72.8 bits (177), Expect = 5e-13
Identities = 45/158 (28%), Positives = 76/158 (48%), Gaps = 1/158 (0%)
Query: 11 LEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L+AA G+ + +A+G T D + LH A+ GH E LL G + D + +
Sbjct: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
+D T +H A GH +V++L HGAD N +D L T LH A E+VE + G +
Sbjct: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE 272
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTN 167
++ + + TA ++ + ++L + + + N
Sbjct: 273 INARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKN 310
Score = 49.7 bits (117), Expect = 4e-06
Identities = 28/88 (31%), Positives = 43/88 (48%)
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
VD AA EG ++E L G + D + TALH A+ H E++E L+ GA
Sbjct: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQ 157
V Q + TA + G+ ++ ++LQ
Sbjct: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQ 234
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 81.6 bits (200), Expect = 1e-15
Identities = 53/166 (31%), Positives = 82/166 (49%), Gaps = 9/166 (5%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G LHLAA GH+ ++LL AG +A T + TPL +A G ++ +LL+HGA+V
Sbjct: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
Query: 98 N-AKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
N + M +LH A+ + E+++LL++ GA+ Q F T ++ G E L
Sbjct: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK---LESL 122
Query: 157 QIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENS 202
I + + N N ++ D ATP FI G L+ S +
Sbjct: 123 SILISSGANVNCQALD-----KATPLFIAAQEGHTKCVELLLSSGA 163
Score = 63.9 bits (154), Expect = 2e-10
Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 2/122 (1%)
Query: 10 LLEAARAGQDDEVRILMANGAPF--TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
L A GQ D +R+L+ +GA + G + LH A+ + ++LLR G +++ +
Sbjct: 43 LFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQ 102
Query: 68 TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
TPL +AA G + +L+ GA+VN + + K T L A + H + VELL+ G
Sbjct: 103 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 162
Query: 128 AD 129
AD
Sbjct: 163 AD 164
Score = 56.2 bits (134), Expect = 4e-08
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 3/128 (2%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLG-TSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L AA+ G+ + + IL+++GA L +PL +AAQ GH E+LL +G D
Sbjct: 110 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYC 169
Query: 69 KVD--RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
D + P+H AA GH I+++L+ + K++ ++ A H++ +E+L++
Sbjct: 170 NEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRN 229
Query: 127 GADVHTQS 134
G Q+
Sbjct: 230 GYSPDAQA 237
Score = 46.6 bits (109), Expect = 3e-05
Identities = 35/137 (25%), Positives = 68/137 (49%), Gaps = 10/137 (7%)
Query: 4 VDLGKKLLEAARAGQDDEVRILMANGAP---FTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
+D L AA+ G V +L+++GA + + P+H AAQ GH ++L+
Sbjct: 137 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL 196
Query: 61 GVSRDARTKVDR-TPLHMAASEGHASIVEVLLKHGADVNAKDML-----KMTALHWATEH 114
+R T +++ +P++ A GH +E+LL++G +A+ L + + +
Sbjct: 197 -TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC 255
Query: 115 NHQEVVELLIKYGADVH 131
+V +L+KYGA ++
Sbjct: 256 EFFGIVNILLKYGAQIN 272
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 81.6 bits (200), Expect = 1e-15
Identities = 55/164 (33%), Positives = 83/164 (50%), Gaps = 6/164 (3%)
Query: 11 LEAARAGQDDEV-RILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L+AA Q+ + + L G P D L + LH A GH LL AG + DAR
Sbjct: 116 LKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDL 175
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
+DRTP+ A GH I++ LL GA VNA+D + T LH A H + +E LI+ GA
Sbjct: 176 LDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAH 235
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEIL-----QIAMQNQINTNP 168
++ Q K TA ++ +G+ ++L ++ ++N + P
Sbjct: 236 LNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTP 279
Score = 70.5 bits (171), Expect = 2e-12
Identities = 40/124 (32%), Positives = 65/124 (52%)
Query: 23 RILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
++L+A D L +P+ A + GH + LL G +AR K+ TPLH+A
Sbjct: 162 KLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTR 221
Query: 83 HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
H +E L++ GA +NA+D TALH A H + ++LL+ YGA++ ++ T
Sbjct: 222 HPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQ 281
Query: 143 ISID 146
++ D
Sbjct: 282 LARD 285
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 81.6 bits (200), Expect = 1e-15
Identities = 53/166 (31%), Positives = 82/166 (49%), Gaps = 9/166 (5%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G LHLAA GH+ ++LL AG +A T + TPL +A G ++ +LL+HGA+V
Sbjct: 79 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 138
Query: 98 N-AKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
N + M +LH A+ + E+++LL++ GA+ Q F T ++ G E L
Sbjct: 139 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK---LESL 195
Query: 157 QIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENS 202
I + + N N ++ D ATP FI G L+ S +
Sbjct: 196 SILISSGANVNCQALD-----KATPLFIAAQEGHTKCVELLLSSGA 236
Score = 63.9 bits (154), Expect = 2e-10
Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 2/122 (1%)
Query: 10 LLEAARAGQDDEVRILMANGAPF--TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
L A GQ D +R+L+ +GA + G + LH A+ + ++LLR G +++ +
Sbjct: 116 LFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQ 175
Query: 68 TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
TPL +AA G + +L+ GA+VN + + K T L A + H + VELL+ G
Sbjct: 176 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 235
Query: 128 AD 129
AD
Sbjct: 236 AD 237
Score = 56.2 bits (134), Expect = 4e-08
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 3/128 (2%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLG-TSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L AA+ G+ + + IL+++GA L +PL +AAQ GH E+LL +G D
Sbjct: 183 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYC 242
Query: 69 KVD--RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
D + P+H AA GH I+++L+ + K++ ++ A H++ +E+L++
Sbjct: 243 NEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRN 302
Query: 127 GADVHTQS 134
G Q+
Sbjct: 303 GYSPDAQA 310
Score = 54.7 bits (130), Expect = 1e-07
Identities = 56/206 (27%), Positives = 90/206 (43%), Gaps = 45/206 (21%)
Query: 32 FTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTP---------------- 74
FT + T S + LAA+ G+ LL+ G S D P
Sbjct: 3 FTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQML 62
Query: 75 --------------------LHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEH 114
LH+AAS+GH IV++LL+ GAD NA + + T L A E+
Sbjct: 63 INADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVEN 122
Query: 115 NHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTV 174
+V+ LL+++GA+V+ C ++ ++ AEI+++ ++ N E D
Sbjct: 123 GQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKLLLRK--GANKECQDDF 178
Query: 175 TIHAATPQFIIGP-GGVVNLTGLVSS 199
I TP F+ G + +L+ L+SS
Sbjct: 179 GI---TPLFVAAQYGKLESLSILISS 201
Score = 46.6 bits (109), Expect = 3e-05
Identities = 35/137 (25%), Positives = 68/137 (49%), Gaps = 10/137 (7%)
Query: 4 VDLGKKLLEAARAGQDDEVRILMANGAP---FTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
+D L AA+ G V +L+++GA + + P+H AAQ GH ++L+
Sbjct: 210 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL 269
Query: 61 GVSRDARTKVDR-TPLHMAASEGHASIVEVLLKHGADVNAKDML-----KMTALHWATEH 114
+R T +++ +P++ A GH +E+LL++G +A+ L + + +
Sbjct: 270 -TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC 328
Query: 115 NHQEVVELLIKYGADVH 131
+V +L+KYGA ++
Sbjct: 329 EFFGIVNILLKYGAQIN 345
>gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
Length = 327
Score = 79.3 bits (194), Expect = 5e-15
Identities = 47/134 (35%), Positives = 73/134 (54%), Gaps = 1/134 (0%)
Query: 11 LEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L+AA G+ + +A+G T D + LH A+ GH E LL G + D + +
Sbjct: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
+D T +H A GH +V++L HGAD N +D TALH A N ++++LL+ +GAD
Sbjct: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGAD 272
Query: 130 VHTQSKFCKTAFDI 143
+ T++ KT D+
Sbjct: 273 MMTKNLAGKTPTDL 286
Score = 73.2 bits (178), Expect = 3e-13
Identities = 44/123 (35%), Positives = 63/123 (51%)
Query: 45 AAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLK 104
AA G E L G S D + RT LH A+ EGH I+E LL +GA V+ +D L
Sbjct: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
Query: 105 MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQI 164
TA+HWA H EVV+LL +GAD + + K TA ++ + ++L + + +
Sbjct: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
Query: 165 NTN 167
N
Sbjct: 275 TKN 277
Score = 49.7 bits (117), Expect = 4e-06
Identities = 28/88 (31%), Positives = 43/88 (48%)
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
VD AA EG ++E L G + D + TALH A+ H E++E L+ GA
Sbjct: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQ 157
V Q + TA + G+ ++ ++LQ
Sbjct: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQ 234
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 79.0 bits (193), Expect = 6e-15
Identities = 49/133 (36%), Positives = 72/133 (54%), Gaps = 1/133 (0%)
Query: 25 LMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
++ +G TT D G + LHLAA+YGH + LL+ + RT LH AA
Sbjct: 74 ILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADC 133
Query: 84 ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
S +++L HGA VNAKD+ T L AT+ + + +LLI GADV+++ K +TA +
Sbjct: 134 PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALML 193
Query: 144 SIDNGNEDLAEIL 156
+ G D E+L
Sbjct: 194 GCEYGCRDAVEVL 206
Score = 63.5 bits (153), Expect = 3e-10
Identities = 43/140 (30%), Positives = 69/140 (49%)
Query: 23 RILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
++L N D G + LH AA S+ ++L G S +A+ RTPL +A
Sbjct: 106 KLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMS 165
Query: 83 HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
+I ++L+ GADVN++D TAL E+ ++ VE+LIK GAD+ +
Sbjct: 166 RPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSY 225
Query: 143 ISIDNGNEDLAEILQIAMQN 162
+ N D+ +L+ A +N
Sbjct: 226 YARIGDNLDILTLLKTASEN 245
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,612,216
Number of Sequences: 37866
Number of extensions: 522976
Number of successful extensions: 3977
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 360
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 1254
Number of HSP's gapped (non-prelim): 1638
length of query: 360
length of database: 18,247,518
effective HSP length: 103
effective length of query: 257
effective length of database: 14,347,320
effective search space: 3687261240
effective search space used: 3687261240
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.