Search of human proteins with 8051593

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8051593 GA binding protein transcription factor, beta
subunit 1 isoform beta 1 [Homo sapiens]
         (395 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8051593 GA binding protein transcription factor, beta subunit...   762   0.0  
gi|8051595 GA binding protein transcription factor, beta subunit...   732   0.0  
gi|8051597 GA binding protein transcription factor, beta subunit...   671   0.0  
gi|32483404 GA binding protein transcription factor, beta subuni...   641   0.0  
gi|8051599 GA binding protein transcription factor, beta subunit...   641   0.0  
gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens]          498   e-141
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    97   2e-20
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    96   6e-20
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        92   8e-19
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         92   8e-19
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         92   8e-19
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         92   8e-19
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         92   8e-19
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     92   8e-19
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        91   1e-18
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         91   1e-18
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         91   1e-18
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]             84   2e-16
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         84   2e-16
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]     84   2e-16
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                     83   5e-16
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...    82   6e-16
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...    82   6e-16
gi|89363047 death-associated protein kinase 1 [Homo sapiens]           82   1e-15
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]           82   1e-15
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso...    82   1e-15
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]     82   1e-15
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof...    82   1e-15
gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]          79   5e-15
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr...    79   7e-15

>gi|8051593 GA binding protein transcription factor, beta subunit 1
           isoform beta 1 [Homo sapiens]
          Length = 395

 Score =  762 bits (1968), Expect = 0.0
 Identities = 395/395 (100%), Positives = 395/395 (100%)

Query: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
           MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
           GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120

Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
           ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180

Query: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
           PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240

Query: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
           SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300

Query: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANRE 360
           MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANRE
Sbjct: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANRE 360

Query: 361 AQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV 395
           AQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV
Sbjct: 361 AQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV 395


>gi|8051595 GA binding protein transcription factor, beta subunit 1
           isoform beta 2 [Homo sapiens]
          Length = 383

 Score =  732 bits (1890), Expect = 0.0
 Identities = 383/395 (96%), Positives = 383/395 (96%), Gaps = 12/395 (3%)

Query: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
           MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
           GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120

Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
           ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180

Query: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
           PQFIIGPGGVVNL            TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 228

Query: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
           SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 229 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 288

Query: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANRE 360
           MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANRE
Sbjct: 289 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANRE 348

Query: 361 AQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV 395
           AQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV
Sbjct: 349 AQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV 383


>gi|8051597 GA binding protein transcription factor, beta subunit 1
           isoform gamma 1 [Homo sapiens]
          Length = 360

 Score =  671 bits (1731), Expect = 0.0
 Identities = 347/350 (99%), Positives = 347/350 (99%)

Query: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
           MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
           GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120

Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
           ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180

Query: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
           PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240

Query: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
           SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300

Query: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREAL 350
           MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIE R  L
Sbjct: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLL 350


>gi|32483404 GA binding protein transcription factor, beta subunit 1
           isoform gamma 2 [Homo sapiens]
          Length = 348

 Score =  641 bits (1653), Expect = 0.0
 Identities = 335/350 (95%), Positives = 335/350 (95%), Gaps = 12/350 (3%)

Query: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
           MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
           GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120

Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
           ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180

Query: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
           PQFIIGPGGVVNL            TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 228

Query: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
           SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 229 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 288

Query: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREAL 350
           MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIE R  L
Sbjct: 289 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLL 338


>gi|8051599 GA binding protein transcription factor, beta subunit 1
           isoform gamma 2 [Homo sapiens]
          Length = 348

 Score =  641 bits (1653), Expect = 0.0
 Identities = 335/350 (95%), Positives = 335/350 (95%), Gaps = 12/350 (3%)

Query: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
           MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
           GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120

Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
           ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180

Query: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
           PQFIIGPGGVVNL            TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 228

Query: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
           SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 229 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 288

Query: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREAL 350
           MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIE R  L
Sbjct: 289 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLL 338


>gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens]
          Length = 448

 Score =  498 bits (1283), Expect = e-141
 Identities = 274/400 (68%), Positives = 311/400 (77%), Gaps = 11/400 (2%)

Query: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
           MSLVDLGK+LLEAAR GQDDEVR LMANGAPFTTDWLGTSPLHLAAQYGHYST EVLLRA
Sbjct: 1   MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA 60

Query: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
           GVSRDARTKVDRTPLHMAA++GHA IVE+L+++GADVNAKDMLKMTALHWATE +H++VV
Sbjct: 61  GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV 120

Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT--IHA 178
           ELLIKYGADVH  SKF K+AFDI+++  N ++  ILQ AMQNQ+N NPE  + VT  +  
Sbjct: 121 ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM 180

Query: 179 ATPQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLS 238
           A P FI   G VVNL  L+SS N+   + +   S VQF NS+TSVLATLAALAEAS PLS
Sbjct: 181 AAP-FIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLS 239

Query: 239 NSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH-SIPTSGIGQPI 297
           NS       TEE++   SVD +IQQV+ SGGQ+VITIVTDG+ LGN+  SIPT GIGQP 
Sbjct: 240 NSHRA-TANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPF 298

Query: 298 IVTMPDGQQVLTVPATDIAEETVISEE-----PPAKRQCIEIIENRV-ESAEIEEREALQ 351
           IVT+ DGQQVLTVPA  +AEETVI EE     P  K+  I    N V ES E  ERE LQ
Sbjct: 299 IVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQ 358

Query: 352 KQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRLQTN 391
           +QL EANR AQ+YR QLLKKEQEAE YR KLEA+ R Q N
Sbjct: 359 QQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPN 398


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 55/138 (39%), Positives = 80/138 (57%), Gaps = 2/138 (1%)

Query: 9   KLLEAARAGQDDEVRILMA--NGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDA 66
           +LLE+AR+G ++++  L+   N     +D   ++PLHLAA Y      ++LL+ G    A
Sbjct: 180 ELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHA 239

Query: 67  RTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
           + K D  PLH A S GH  + E+L+KHGA VNA D+ + T LH A   N  EV  LL+ Y
Sbjct: 240 KDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSY 299

Query: 127 GADVHTQSKFCKTAFDIS 144
           GAD    +   K+A D++
Sbjct: 300 GADPTLLNCHNKSAIDLA 317



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 56/152 (36%), Positives = 86/152 (56%), Gaps = 3/152 (1%)

Query: 8   KKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRD 65
           ++LLEAA+AG  + V+ L    +    D  G  ++PLH AA Y   S  E LL+ G    
Sbjct: 494 RQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVH 553

Query: 66  ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
           A+ K    PLH A S GH  + E+L+KHGA VN  D+ K T LH A      E+ +LL++
Sbjct: 554 AKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613

Query: 126 YGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
           +GAD   +++   T  D+ + +G+ D+ ++L+
Sbjct: 614 HGADPTKKNRDGNTPLDL-VKDGDTDIQDLLR 644



 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 50/139 (35%), Positives = 76/139 (54%), Gaps = 2/139 (1%)

Query: 8   KKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRD 65
           ++L EA R G  + V+ L+      + D  G  ++PLH AA +G     E LL+ G +  
Sbjct: 26  RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ 85

Query: 66  ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
           AR      PLH A S GHA +V +LL+HGAD NA+D    T LH A      +V  +L++
Sbjct: 86  ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145

Query: 126 YGADVHTQSKFCKTAFDIS 144
           +GA+   ++   +TA D++
Sbjct: 146 HGAEPTIRNTDGRTALDLA 164



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 63/222 (28%), Positives = 107/222 (48%), Gaps = 19/222 (8%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
           LL+AA+ G    V+ L +       D  G  ++PLHLAA Y +    E LL+ G   +A+
Sbjct: 649 LLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQ 708

Query: 68  TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
            K    PLH AAS GH  +  +L+K+ A VNA D    T LH A +    ++  LL+ +G
Sbjct: 709 DKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 768

Query: 128 ADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQ-------------NQINTNPESPDTV 174
           AD   +++  +T  D+      +D++ +L  AM              N + +   + D +
Sbjct: 769 ADPTLKNQEGQTPLDLV---SADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADAL 825

Query: 175 TIHAATPQFIIGPGGVVNLTGLVSSENSSKATDET-GVSAVQ 215
           +   ++P  +     + NL+G  S  +S  ++  T G S+++
Sbjct: 826 SSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLE 867



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 57/157 (36%), Positives = 80/157 (50%), Gaps = 12/157 (7%)

Query: 7   GKKLLEAARAGQDDEVRI---LMANGAPFTTDWLGTSPLHLAAQYGH---YSTTEVLLRA 60
           G  LL+AAR  + D  RI   L      F       + LH AA   +       E+LLR 
Sbjct: 332 GHSLLQAAR--EADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRK 389

Query: 61  GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
           G + + +TK   TPLH+A+ + H  +VEV++KH A VNA D L  T+LH A    H +  
Sbjct: 390 GANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTC 449

Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
            LL+ YG D +  S    TA  +    GNE++ ++LQ
Sbjct: 450 RLLLSYGCDPNIISLQGFTALQM----GNENVQQLLQ 482



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 58/199 (29%), Positives = 82/199 (41%), Gaps = 55/199 (27%)

Query: 13  AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G+ D V  L+ NGA     D  G  PLH A  +GH     +LLR G   +AR   +
Sbjct: 65  AAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWN 124

Query: 72  RTPLHMAASEGHASIVEVLLKHG----------------ADVNAKDML------------ 103
            TPLH AA +G   +  VLL+HG                AD +AK +L            
Sbjct: 125 YTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLES 184

Query: 104 --------------------------KMTALHWATEHNHQEVVELLIKYGADVHTQSKFC 137
                                     K T LH A  +N  ++V+LL+++GADVH + K  
Sbjct: 185 ARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGD 244

Query: 138 KTAFDISIDNGNEDLAEIL 156
                 +   G+ ++ E+L
Sbjct: 245 LVPLHNACSYGHYEVTELL 263



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 32/84 (38%), Positives = 47/84 (55%)

Query: 73  TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
           TPLH AA  G   +VE LL++GA+V A+D   +  LH A    H EVV LL+++GAD + 
Sbjct: 60  TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119

Query: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
           +  +  T    +   G  D+  +L
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVL 143



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 47/173 (27%), Positives = 73/173 (42%), Gaps = 30/173 (17%)

Query: 13  AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           A+    +D V +++ + A     D LG + LH AA  GH  T  +LL  G   +  +   
Sbjct: 407 ASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG 466

Query: 72  RTPLHM--------------------------AASEGHASIVEVLLKHGADVNAKDM--L 103
            T L M                          AA  G    V+ L    + VN +D+   
Sbjct: 467 FTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGR 525

Query: 104 KMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           + T LH+A  +N   VVE L+++GADVH + K        +   G+ ++AE+L
Sbjct: 526 QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELL 578



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 33/112 (29%), Positives = 50/112 (44%), Gaps = 15/112 (13%)

Query: 40  SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNA 99
           +PLH+A++  H    EV+++     +A   + +T LH AA  GH     +LL +G D N 
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461

Query: 100 KDMLKMTALHWATEHNHQEVVELLIKYG--------------ADVHTQSKFC 137
             +   TAL    E N Q++++  I  G               DV T  K C
Sbjct: 462 ISLQGFTALQMGNE-NVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score = 95.9 bits (237), Expect = 6e-20
 Identities = 56/155 (36%), Positives = 86/155 (55%), Gaps = 3/155 (1%)

Query: 5   DLGKKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGV 62
           D+  +LLEA++AG  + V+ L ++      D  G  ++PLH AA Y   S  E LL  G 
Sbjct: 649 DVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGA 708

Query: 63  SRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVEL 122
              A+ K    PLH A S GH  + E+L++HGA VN  D+ K T LH A      E+ +L
Sbjct: 709 DVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKL 768

Query: 123 LIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
           L+K+GAD   +++   T  D+ +  G+ D+ ++L+
Sbjct: 769 LLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLLR 802



 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 55/138 (39%), Positives = 79/138 (57%), Gaps = 2/138 (1%)

Query: 9   KLLEAARAGQDDEVRILMA--NGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDA 66
           +LLEAAR+G ++++  L+   N     +D   ++PLHLAA Y      ++LL+ G    A
Sbjct: 338 ELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 397

Query: 67  RTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
           + K    PLH A S GH  + E+LLKHGA VNA D+ + T LH A   N  EV  LL+ +
Sbjct: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457

Query: 127 GADVHTQSKFCKTAFDIS 144
           GAD    +   K+A D++
Sbjct: 458 GADPTLVNCHGKSAVDMA 475



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 52/139 (37%), Positives = 74/139 (53%), Gaps = 2/139 (1%)

Query: 8   KKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRD 65
           ++LLEA R G    V+ L+        D  G  +SPLH AA +G     E LL+ G +  
Sbjct: 184 RELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH 243

Query: 66  ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
           AR      PLH A S GHA +V +LL  GAD NA+D    T LH A      +V  +L++
Sbjct: 244 ARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 303

Query: 126 YGADVHTQSKFCKTAFDIS 144
           +GAD + ++   K+A D++
Sbjct: 304 HGADPNIRNTDGKSALDLA 322



 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 60/194 (30%), Positives = 90/194 (46%), Gaps = 11/194 (5%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
           LL+AA+ G    V+ L         D  G  ++PLHLAA Y +    E LL  G   +A+
Sbjct: 807 LLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ 866

Query: 68  TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
            K    PLH AAS GH  I  +L+K+   VNA D    T LH A +    ++  LL+ +G
Sbjct: 867 DKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 926

Query: 128 ADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIH------AATP 181
           AD   +++  +T  D++     +D+  +L  AM  +       P    +       A+TP
Sbjct: 927 ADPTMKNQEGQTPLDLAT---ADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTP 983

Query: 182 QFIIGPGGVVNLTG 195
             +     + NLTG
Sbjct: 984 SCLSAASSIDNLTG 997



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 57/154 (37%), Positives = 76/154 (49%), Gaps = 8/154 (5%)

Query: 7   GKKLLEAARAGQDDEVRILMA-NGAPFTTDWLGTSPLHLAAQYGH---YSTTEVLLRAGV 62
           G  LL+AAR     +V+  +A     F       + LH A    H      TE+LLR G 
Sbjct: 490 GHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549

Query: 63  SRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVEL 122
           + + + K   TPLH+AA   H  ++EVL KHGA +NA D L  TALH A    H +   L
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609

Query: 123 LIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           L+ YG+D    S    TA  +    GNE + +IL
Sbjct: 610 LLSYGSDPSIISLQGFTAAQM----GNEAVQQIL 639



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 56/199 (28%), Positives = 79/199 (39%), Gaps = 55/199 (27%)

Query: 13  AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G+ D V  L+  GA     D  G  PLH A  +GH     +LL  G   +AR   +
Sbjct: 223 AAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWN 282

Query: 72  RTPLHMAASEGHASIVEVLLKHG----------------ADVNAKDML------------ 103
            TPLH AA +G   +  VLL+HG                AD +AK +L            
Sbjct: 283 YTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEA 342

Query: 104 --------------------------KMTALHWATEHNHQEVVELLIKYGADVHTQSKFC 137
                                     K T LH A  +N   +V+LL+++GADVH + K  
Sbjct: 343 ARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG 402

Query: 138 KTAFDISIDNGNEDLAEIL 156
                 +   G+ ++ E+L
Sbjct: 403 LVPLHNACSYGHYEVTELL 421



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 31/84 (36%), Positives = 45/84 (53%)

Query: 73  TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
           +PLH AA  G   +VE LL+ GA+V+A+D   +  LH A    H EVV LL+  GAD + 
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 277

Query: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
           +  +  T    +   G  D+  +L
Sbjct: 278 RDNWNYTPLHEAAIKGKIDVCIVL 301



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 27/82 (32%), Positives = 40/82 (48%)

Query: 40  SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNA 99
           +PLH+AA+  H    EVL + G   +A   + +T LH AA  GH     +LL +G+D + 
Sbjct: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619

Query: 100 KDMLKMTALHWATEHNHQEVVE 121
             +   TA     E   Q + E
Sbjct: 620 ISLQGFTAAQMGNEAVQQILSE 641


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 92.0 bits (227), Expect = 8e-19
 Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)

Query: 13  AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G  + V +L++  A     +  G +PLHL AQ GH    +VL++ GV  DA T++ 
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+A+  G+  +V+ LL+H ADVNAK  L  + LH A +  H ++V LL+K GA  +
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
             S    T   I+   G   + ++L++
Sbjct: 795 EVSSDGTTPLAIAKRLGYISVTDVLKV 821



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 60/198 (30%), Positives = 99/198 (50%), Gaps = 14/198 (7%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+  Q +  R L+  G     + + G +PLHLAAQ GH     +LL    + +   K  
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+ A EGH  + +VL+KHG  V+A   +  T LH A+ + + ++V+ L+++ ADV+
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
            ++K   +    +   G+ D+  +L          N  SP+ V+    TP  I    G +
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 813

Query: 192 NLTGLVSSENSSKATDET 209
           ++T ++        TDET
Sbjct: 814 SVTDVL-----KVVTDET 826



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 59/192 (30%), Positives = 93/192 (48%), Gaps = 9/192 (4%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G  + V++L+ N A P      G +PLH+AA+ GH  T   LL    S+   TK  
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA  G   + E+LL+  A  NA     +T LH A  HN+ ++V+LL+  G   H
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
           + +    T   I+     ++  E+ +  +Q   + N ES     +   TP  +    G  
Sbjct: 630 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAES-----VQGVTPLHLAAQEGHA 681

Query: 192 NLTGLVSSENSS 203
            +  L+ S+ ++
Sbjct: 682 EMVALLLSKQAN 693



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 10/200 (5%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G     ++L+  GA P +    G +PLH+A +  H    E+LL+ G S DA T+  
Sbjct: 378 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 437

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+A+  GH  IV+ LL+ GA  N  ++   T LH A    H EV + L++  A V+
Sbjct: 438 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 497

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIG-PGGV 190
            ++K  +T    +   G+ ++ ++L   ++N  N     P+  T    TP  I    G V
Sbjct: 498 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 549

Query: 191 VNLTGLVSSENSSKATDETG 210
             +  L+  E S     + G
Sbjct: 550 ETVLALLEKEASQACMTKKG 569



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 4/152 (2%)

Query: 20  DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
           D V++L+  G +P +  W G +PLH+AA+         LL+ G S +A +    TPLH+A
Sbjct: 616 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 675

Query: 79  ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
           A EGHA +V +LL   A+ N  +   +T LH   +  H  V ++LIK+G  V   ++   
Sbjct: 676 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 735

Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPES 170
           T   ++   GN  L + L   +Q+Q + N ++
Sbjct: 736 TPLHVASHYGNIKLVKFL---LQHQADVNAKT 764



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 23/243 (9%)

Query: 5   DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
           D     L AAR+G  D+    + NG    T +  G + LHLA++ GH      LL   + 
Sbjct: 44  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 103

Query: 64  RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
            +  TK   T LH+AA  G   +V  L+ +GA+VNA+     T L+ A + NH EVV+ L
Sbjct: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163

Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
           ++ GA+ +  ++   T   +++  G+E++                 L IA +N       
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 223

Query: 164 -INTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAVQFGNSST 221
            +  N  +PD ++    TP  I      +N+  L+ +  +S   T + G++ +   +   
Sbjct: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283

Query: 222 SVL 224
           +V+
Sbjct: 284 NVI 286



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 44/135 (32%), Positives = 75/135 (55%), Gaps = 1/135 (0%)

Query: 23  RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
           ++L+  GA    T   G +PLH+A++ G+     +LL  G   + +TK + TPLH AA  
Sbjct: 256 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 315

Query: 82  GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
           GH  I E+LL HGA + AK    ++ +H A + +H + V LL++Y A++   +    T  
Sbjct: 316 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 375

Query: 142 DISIDNGNEDLAEIL 156
            ++   G+  +A++L
Sbjct: 376 HVAAHCGHHRVAKVL 390



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 63/198 (31%), Positives = 103/198 (52%), Gaps = 13/198 (6%)

Query: 13  AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           AA+    D VR+L+   A     T D L  +PLH+AA  GH+   +VLL  G   ++R  
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 402

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
              TPLH+A  + H  ++E+LLK GA ++A     +T LH A+   H  +V+ L++ GA 
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 462

Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
            +  +   +T   ++   G+ ++A+ L   +QN+   N ++ D  T +H A     IG  
Sbjct: 463 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 516

Query: 189 GVVNLTGLVSSENSSKAT 206
            +V L  L ++ N + AT
Sbjct: 517 NMVKLL-LENNANPNLAT 533



 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 56/162 (34%), Positives = 81/162 (50%), Gaps = 3/162 (1%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G      IL+ +GAP       G SP+H+AAQ  H     +LL+     D  T   
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA  GH  + +VLL  GA  N++ +   T LH A + NH  V+ELL+K GA + 
Sbjct: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP 171
             ++   T   ++   G+  + + L  + A  N  N   E+P
Sbjct: 432 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 473



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 13/202 (6%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           A+R G    VR+L+  GA   T      +PLH AA+ GH   +E+LL  G    A+TK  
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            +P+HMAA   H   V +LL++ A+++   +  +T LH A    H  V ++L+  GA  +
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG-- 189
           +++    T   I+    +  + E+L       + T   S D VT    TP  +    G  
Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELL-------LKTG-ASIDAVTESGLTPLHVASFMGHL 450

Query: 190 --VVNLTGLVSSENSSKATDET 209
             V NL    +S N S    ET
Sbjct: 451 PIVKNLLQRGASPNVSNVKVET 472



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)

Query: 24  ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
           +L    +P  ++    +PLH+AA+ GH    + LL+     +A+ K D+TPLH AA  GH
Sbjct: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 515

Query: 84  ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
            ++V++LL++ A+ N       T LH A    H E V  L++  A     +K   T   +
Sbjct: 516 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 575

Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
           +   G   +AE+L  + A  N    N  +P  V +H
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 611



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 42/134 (31%), Positives = 71/134 (52%), Gaps = 5/134 (3%)

Query: 7   GKKLLEAAR-AGQDDEVR----ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
           GK  L A   A ++D+ R    +L  +  P      G +PLH+AA Y + +  ++LL  G
Sbjct: 203 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 262

Query: 62  VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
            S +   +   TPLH+A+  G+  +V +LL  GA +  K   ++T LH A  + H  + E
Sbjct: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322

Query: 122 LLIKYGADVHTQSK 135
           +L+ +GA +  ++K
Sbjct: 323 ILLDHGAPIQAKTK 336



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 64/244 (26%), Positives = 101/244 (41%), Gaps = 11/244 (4%)

Query: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
           +S V +   L  AARAG  +  + L+ N A          +PLH AA+ GH +  ++LL 
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524

Query: 60  AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
              + +  T    TPLH+AA EGH   V  LL+  A          T LH A ++    V
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 584

Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
            ELL++  A  +   K   T   +++ + N D+ ++L             SP +   +  
Sbjct: 585 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 636

Query: 180 TPQFIIGPGGVVNLT-GLVSSENSSKATDETGVSAVQF-GNSSTSVLATLAALAEASAPL 237
           TP  I      V +   L+    S+ A    GV+ +        + +  L    +A+  L
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696

Query: 238 SNSS 241
            N S
Sbjct: 697 GNKS 700



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 41/145 (28%), Positives = 71/145 (48%), Gaps = 1/145 (0%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G+     +L+   A P      G +PLH+A  + +    ++LL  G S  +     
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA +    +   LL++G   NA+ +  +T LH A +  H E+V LL+   A+ +
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
             +K   T   +    G+  +A++L
Sbjct: 696 LGNKSGLTPLHLVAQEGHVPVADVL 720



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 39/115 (33%), Positives = 62/115 (53%)

Query: 42  LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
           LH+AA+     T  VLL+   + D  +K   TPLH+AA   + ++ ++LL  GA VN   
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269

Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
              +T LH A+   +  +V LL+  GA + T++K   T    +  NG+  ++EIL
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 49/174 (28%), Positives = 75/174 (43%), Gaps = 30/174 (17%)

Query: 13  AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA AGQD+ VR L+  GA        G +PL++AAQ  H    + LL  G +++  T+  
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177

Query: 72  RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
            TPL +A  +GH ++V  L+ +G                            D N   + K
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237

Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
              T LH A  + +  V +LL+  GA V+   +   T   I+   GN  +  +L
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 291


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 92.0 bits (227), Expect = 8e-19
 Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)

Query: 13  AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G  + V +L++  A     +  G +PLHL AQ GH    +VL++ GV  DA T++ 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+A+  G+  +V+ LL+H ADVNAK  L  + LH A +  H ++V LL+K GA  +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
             S    T   I+   G   + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 60/198 (30%), Positives = 99/198 (50%), Gaps = 14/198 (7%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+  Q +  R L+  G     + + G +PLHLAAQ GH     +LL    + +   K  
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+ A EGH  + +VL+KHG  V+A   +  T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
            ++K   +    +   G+ D+  +L          N  SP+ V+    TP  I    G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 192 NLTGLVSSENSSKATDET 209
           ++T ++        TDET
Sbjct: 781 SVTDVL-----KVVTDET 793



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 59/192 (30%), Positives = 93/192 (48%), Gaps = 9/192 (4%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G  + V++L+ N A P      G +PLH+AA+ GH  T   LL    S+   TK  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA  G   + E+LL+  A  NA     +T LH A  HN+ ++V+LL+  G   H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
           + +    T   I+     ++  E+ +  +Q   + N ES     +   TP  +    G  
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAES-----VQGVTPLHLAAQEGHA 648

Query: 192 NLTGLVSSENSS 203
            +  L+ S+ ++
Sbjct: 649 EMVALLLSKQAN 660



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 10/200 (5%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G     ++L+  GA P +    G +PLH+A +  H    E+LL+ G S DA T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+A+  GH  IV+ LL+ GA  N  ++   T LH A    H EV + L++  A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIG-PGGV 190
            ++K  +T    +   G+ ++ ++L   ++N  N     P+  T    TP  I    G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516

Query: 191 VNLTGLVSSENSSKATDETG 210
             +  L+  E S     + G
Sbjct: 517 ETVLALLEKEASQACMTKKG 536



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 4/152 (2%)

Query: 20  DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
           D V++L+  G +P +  W G +PLH+AA+         LL+ G S +A +    TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 79  ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
           A EGHA +V +LL   A+ N  +   +T LH   +  H  V ++LIK+G  V   ++   
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPES 170
           T   ++   GN  L + L   +Q+Q + N ++
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKT 731



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 23/243 (9%)

Query: 5   DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
           D     L AAR+G  D+    + NG    T +  G + LHLA++ GH      LL   + 
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 64  RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
            +  TK   T LH+AA  G   +V  L+ +GA+VNA+     T L+ A + NH EVV+ L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
           ++ GA+ +  ++   T   +++  G+E++                 L IA +N       
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 164 -INTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAVQFGNSST 221
            +  N  +PD ++    TP  I      +N+  L+ +  +S   T + G++ +   +   
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 222 SVL 224
           +V+
Sbjct: 251 NVI 253



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 44/135 (32%), Positives = 75/135 (55%), Gaps = 1/135 (0%)

Query: 23  RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
           ++L+  GA    T   G +PLH+A++ G+     +LL  G   + +TK + TPLH AA  
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 82  GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
           GH  I E+LL HGA + AK    ++ +H A + +H + V LL++Y A++   +    T  
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342

Query: 142 DISIDNGNEDLAEIL 156
            ++   G+  +A++L
Sbjct: 343 HVAAHCGHHRVAKVL 357



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 63/198 (31%), Positives = 103/198 (52%), Gaps = 13/198 (6%)

Query: 13  AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           AA+    D VR+L+   A     T D L  +PLH+AA  GH+   +VLL  G   ++R  
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
              TPLH+A  + H  ++E+LLK GA ++A     +T LH A+   H  +V+ L++ GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
            +  +   +T   ++   G+ ++A+ L   +QN+   N ++ D  T +H A     IG  
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483

Query: 189 GVVNLTGLVSSENSSKAT 206
            +V L  L ++ N + AT
Sbjct: 484 NMVKLL-LENNANPNLAT 500



 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 56/162 (34%), Positives = 81/162 (50%), Gaps = 3/162 (1%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G      IL+ +GAP       G SP+H+AAQ  H     +LL+     D  T   
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA  GH  + +VLL  GA  N++ +   T LH A + NH  V+ELL+K GA + 
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP 171
             ++   T   ++   G+  + + L  + A  N  N   E+P
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 13/202 (6%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           A+R G    VR+L+  GA   T      +PLH AA+ GH   +E+LL  G    A+TK  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            +P+HMAA   H   V +LL++ A+++   +  +T LH A    H  V ++L+  GA  +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG-- 189
           +++    T   I+    +  + E+L       + T   S D VT    TP  +    G  
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL-------LKTG-ASIDAVTESGLTPLHVASFMGHL 417

Query: 190 --VVNLTGLVSSENSSKATDET 209
             V NL    +S N S    ET
Sbjct: 418 PIVKNLLQRGASPNVSNVKVET 439



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)

Query: 24  ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
           +L    +P  ++    +PLH+AA+ GH    + LL+     +A+ K D+TPLH AA  GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 84  ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
            ++V++LL++ A+ N       T LH A    H E V  L++  A     +K   T   +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
           +   G   +AE+L  + A  N    N  +P  V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 42/134 (31%), Positives = 71/134 (52%), Gaps = 5/134 (3%)

Query: 7   GKKLLEAAR-AGQDDEVR----ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
           GK  L A   A ++D+ R    +L  +  P      G +PLH+AA Y + +  ++LL  G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 62  VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
            S +   +   TPLH+A+  G+  +V +LL  GA +  K   ++T LH A  + H  + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 122 LLIKYGADVHTQSK 135
           +L+ +GA +  ++K
Sbjct: 290 ILLDHGAPIQAKTK 303



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 64/244 (26%), Positives = 101/244 (41%), Gaps = 11/244 (4%)

Query: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
           +S V +   L  AARAG  +  + L+ N A          +PLH AA+ GH +  ++LL 
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 60  AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
              + +  T    TPLH+AA EGH   V  LL+  A          T LH A ++    V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
            ELL++  A  +   K   T   +++ + N D+ ++L             SP +   +  
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603

Query: 180 TPQFIIGPGGVVNLT-GLVSSENSSKATDETGVSAVQF-GNSSTSVLATLAALAEASAPL 237
           TP  I      V +   L+    S+ A    GV+ +        + +  L    +A+  L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 238 SNSS 241
            N S
Sbjct: 664 GNKS 667



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 83/365 (22%), Positives = 154/365 (42%), Gaps = 42/365 (11%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G+     +L+   A P      G +PLH+A  + +    ++LL  G S  +     
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA +    +   LL++G   NA+ +  +T LH A +  H E+V LL+   A+ +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
             +K   T   +    G+  +A++L   +++ +       D  T    TP  +    G +
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVL---IKHGVMV-----DATTRMGYTPLHVASHYGNI 714

Query: 192 NLTG-LVSSENSSKATDETGVS----AVQFGNSSTSVLATLAALAEASAPLSNSSETPVV 246
            L   L+  +    A  + G S    A Q G+  T ++  L     +   +S+   TP+ 
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 247 ATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH--SIPTSGIGQPIIVTMPDG 304
             + +      D            +V+T  T  + + + H  S P + + + + V+  +G
Sbjct: 773 IAKRLGYISVTDVL----------KVVTDETSFVLVSDKHRMSFPET-VDEILDVSEDEG 821

Query: 305 QQVLTVPA-----TDIAEETVISEEPPAKRQCIEI-IENRVESA-------EIEEREALQ 351
           +++++  A      D+ EE  + +  P   Q +E     R+  A         EE+E   
Sbjct: 822 EELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQAS 881

Query: 352 KQLDE 356
           K+ DE
Sbjct: 882 KEYDE 886



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 39/115 (33%), Positives = 62/115 (53%)

Query: 42  LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
           LH+AA+     T  VLL+   + D  +K   TPLH+AA   + ++ ++LL  GA VN   
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236

Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
              +T LH A+   +  +V LL+  GA + T++K   T    +  NG+  ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 49/174 (28%), Positives = 75/174 (43%), Gaps = 30/174 (17%)

Query: 13  AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA AGQD+ VR L+  GA        G +PL++AAQ  H    + LL  G +++  T+  
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 72  RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
            TPL +A  +GH ++V  L+ +G                            D N   + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
              T LH A  + +  V +LL+  GA V+   +   T   I+   GN  +  +L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 92.0 bits (227), Expect = 8e-19
 Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)

Query: 13  AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G  + V +L++  A     +  G +PLHL AQ GH    +VL++ GV  DA T++ 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+A+  G+  +V+ LL+H ADVNAK  L  + LH A +  H ++V LL+K GA  +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
             S    T   I+   G   + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 60/198 (30%), Positives = 99/198 (50%), Gaps = 14/198 (7%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+  Q +  R L+  G     + + G +PLHLAAQ GH     +LL    + +   K  
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+ A EGH  + +VL+KHG  V+A   +  T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
            ++K   +    +   G+ D+  +L          N  SP+ V+    TP  I    G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 192 NLTGLVSSENSSKATDET 209
           ++T ++        TDET
Sbjct: 781 SVTDVL-----KVVTDET 793



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 59/192 (30%), Positives = 93/192 (48%), Gaps = 9/192 (4%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G  + V++L+ N A P      G +PLH+AA+ GH  T   LL    S+   TK  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA  G   + E+LL+  A  NA     +T LH A  HN+ ++V+LL+  G   H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
           + +    T   I+     ++  E+ +  +Q   + N ES     +   TP  +    G  
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAES-----VQGVTPLHLAAQEGHA 648

Query: 192 NLTGLVSSENSS 203
            +  L+ S+ ++
Sbjct: 649 EMVALLLSKQAN 660



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 10/200 (5%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G     ++L+  GA P +    G +PLH+A +  H    E+LL+ G S DA T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+A+  GH  IV+ LL+ GA  N  ++   T LH A    H EV + L++  A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIG-PGGV 190
            ++K  +T    +   G+ ++ ++L   ++N  N     P+  T    TP  I    G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516

Query: 191 VNLTGLVSSENSSKATDETG 210
             +  L+  E S     + G
Sbjct: 517 ETVLALLEKEASQACMTKKG 536



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 4/152 (2%)

Query: 20  DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
           D V++L+  G +P +  W G +PLH+AA+         LL+ G S +A +    TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 79  ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
           A EGHA +V +LL   A+ N  +   +T LH   +  H  V ++LIK+G  V   ++   
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPES 170
           T   ++   GN  L + L   +Q+Q + N ++
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKT 731



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 23/243 (9%)

Query: 5   DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
           D     L AAR+G  D+    + NG    T +  G + LHLA++ GH      LL   + 
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 64  RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
            +  TK   T LH+AA  G   +V  L+ +GA+VNA+     T L+ A + NH EVV+ L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
           ++ GA+ +  ++   T   +++  G+E++                 L IA +N       
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 164 -INTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAVQFGNSST 221
            +  N  +PD ++    TP  I      +N+  L+ +  +S   T + G++ +   +   
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 222 SVL 224
           +V+
Sbjct: 251 NVI 253



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 44/135 (32%), Positives = 75/135 (55%), Gaps = 1/135 (0%)

Query: 23  RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
           ++L+  GA    T   G +PLH+A++ G+     +LL  G   + +TK + TPLH AA  
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 82  GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
           GH  I E+LL HGA + AK    ++ +H A + +H + V LL++Y A++   +    T  
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342

Query: 142 DISIDNGNEDLAEIL 156
            ++   G+  +A++L
Sbjct: 343 HVAAHCGHHRVAKVL 357



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 63/198 (31%), Positives = 103/198 (52%), Gaps = 13/198 (6%)

Query: 13  AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           AA+    D VR+L+   A     T D L  +PLH+AA  GH+   +VLL  G   ++R  
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
              TPLH+A  + H  ++E+LLK GA ++A     +T LH A+   H  +V+ L++ GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
            +  +   +T   ++   G+ ++A+ L   +QN+   N ++ D  T +H A     IG  
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483

Query: 189 GVVNLTGLVSSENSSKAT 206
            +V L  L ++ N + AT
Sbjct: 484 NMVKLL-LENNANPNLAT 500



 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 56/162 (34%), Positives = 81/162 (50%), Gaps = 3/162 (1%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G      IL+ +GAP       G SP+H+AAQ  H     +LL+     D  T   
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA  GH  + +VLL  GA  N++ +   T LH A + NH  V+ELL+K GA + 
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP 171
             ++   T   ++   G+  + + L  + A  N  N   E+P
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 13/202 (6%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           A+R G    VR+L+  GA   T      +PLH AA+ GH   +E+LL  G    A+TK  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            +P+HMAA   H   V +LL++ A+++   +  +T LH A    H  V ++L+  GA  +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG-- 189
           +++    T   I+    +  + E+L       + T   S D VT    TP  +    G  
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL-------LKTG-ASIDAVTESGLTPLHVASFMGHL 417

Query: 190 --VVNLTGLVSSENSSKATDET 209
             V NL    +S N S    ET
Sbjct: 418 PIVKNLLQRGASPNVSNVKVET 439



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)

Query: 24  ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
           +L    +P  ++    +PLH+AA+ GH    + LL+     +A+ K D+TPLH AA  GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 84  ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
            ++V++LL++ A+ N       T LH A    H E V  L++  A     +K   T   +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
           +   G   +AE+L  + A  N    N  +P  V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 42/134 (31%), Positives = 71/134 (52%), Gaps = 5/134 (3%)

Query: 7   GKKLLEAAR-AGQDDEVR----ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
           GK  L A   A ++D+ R    +L  +  P      G +PLH+AA Y + +  ++LL  G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 62  VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
            S +   +   TPLH+A+  G+  +V +LL  GA +  K   ++T LH A  + H  + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 122 LLIKYGADVHTQSK 135
           +L+ +GA +  ++K
Sbjct: 290 ILLDHGAPIQAKTK 303



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 64/244 (26%), Positives = 101/244 (41%), Gaps = 11/244 (4%)

Query: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
           +S V +   L  AARAG  +  + L+ N A          +PLH AA+ GH +  ++LL 
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 60  AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
              + +  T    TPLH+AA EGH   V  LL+  A          T LH A ++    V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
            ELL++  A  +   K   T   +++ + N D+ ++L             SP +   +  
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603

Query: 180 TPQFIIGPGGVVNLT-GLVSSENSSKATDETGVSAVQF-GNSSTSVLATLAALAEASAPL 237
           TP  I      V +   L+    S+ A    GV+ +        + +  L    +A+  L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 238 SNSS 241
            N S
Sbjct: 664 GNKS 667



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 83/365 (22%), Positives = 154/365 (42%), Gaps = 42/365 (11%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G+     +L+   A P      G +PLH+A  + +    ++LL  G S  +     
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA +    +   LL++G   NA+ +  +T LH A +  H E+V LL+   A+ +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
             +K   T   +    G+  +A++L   +++ +       D  T    TP  +    G +
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVL---IKHGVMV-----DATTRMGYTPLHVASHYGNI 714

Query: 192 NLTG-LVSSENSSKATDETGVS----AVQFGNSSTSVLATLAALAEASAPLSNSSETPVV 246
            L   L+  +    A  + G S    A Q G+  T ++  L     +   +S+   TP+ 
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 247 ATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH--SIPTSGIGQPIIVTMPDG 304
             + +      D            +V+T  T  + + + H  S P + + + + V+  +G
Sbjct: 773 IAKRLGYISVTDVL----------KVVTDETSFVLVSDKHRMSFPET-VDEILDVSEDEG 821

Query: 305 QQVLTVPA-----TDIAEETVISEEPPAKRQCIEI-IENRVESA-------EIEEREALQ 351
           +++++  A      D+ EE  + +  P   Q +E     R+  A         EE+E   
Sbjct: 822 EELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQAS 881

Query: 352 KQLDE 356
           K+ DE
Sbjct: 882 KEYDE 886



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 39/115 (33%), Positives = 62/115 (53%)

Query: 42  LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
           LH+AA+     T  VLL+   + D  +K   TPLH+AA   + ++ ++LL  GA VN   
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236

Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
              +T LH A+   +  +V LL+  GA + T++K   T    +  NG+  ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 49/174 (28%), Positives = 75/174 (43%), Gaps = 30/174 (17%)

Query: 13  AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA AGQD+ VR L+  GA        G +PL++AAQ  H    + LL  G +++  T+  
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 72  RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
            TPL +A  +GH ++V  L+ +G                            D N   + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
              T LH A  + +  V +LL+  GA V+   +   T   I+   GN  +  +L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 92.0 bits (227), Expect = 8e-19
 Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)

Query: 13  AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G  + V +L++  A     +  G +PLHL AQ GH    +VL++ GV  DA T++ 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+A+  G+  +V+ LL+H ADVNAK  L  + LH A +  H ++V LL+K GA  +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
             S    T   I+   G   + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 60/198 (30%), Positives = 99/198 (50%), Gaps = 14/198 (7%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+  Q +  R L+  G     + + G +PLHLAAQ GH     +LL    + +   K  
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+ A EGH  + +VL+KHG  V+A   +  T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
            ++K   +    +   G+ D+  +L          N  SP+ V+    TP  I    G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 192 NLTGLVSSENSSKATDET 209
           ++T ++        TDET
Sbjct: 781 SVTDVL-----KVVTDET 793



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 59/192 (30%), Positives = 93/192 (48%), Gaps = 9/192 (4%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G  + V++L+ N A P      G +PLH+AA+ GH  T   LL    S+   TK  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA  G   + E+LL+  A  NA     +T LH A  HN+ ++V+LL+  G   H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
           + +    T   I+     ++  E+ +  +Q   + N ES     +   TP  +    G  
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAES-----VQGVTPLHLAAQEGHA 648

Query: 192 NLTGLVSSENSS 203
            +  L+ S+ ++
Sbjct: 649 EMVALLLSKQAN 660



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 10/200 (5%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G     ++L+  GA P +    G +PLH+A +  H    E+LL+ G S DA T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+A+  GH  IV+ LL+ GA  N  ++   T LH A    H EV + L++  A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIG-PGGV 190
            ++K  +T    +   G+ ++ ++L   ++N  N     P+  T    TP  I    G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516

Query: 191 VNLTGLVSSENSSKATDETG 210
             +  L+  E S     + G
Sbjct: 517 ETVLALLEKEASQACMTKKG 536



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 4/152 (2%)

Query: 20  DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
           D V++L+  G +P +  W G +PLH+AA+         LL+ G S +A +    TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 79  ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
           A EGHA +V +LL   A+ N  +   +T LH   +  H  V ++LIK+G  V   ++   
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPES 170
           T   ++   GN  L + L   +Q+Q + N ++
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKT 731



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 23/243 (9%)

Query: 5   DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
           D     L AAR+G  D+    + NG    T +  G + LHLA++ GH      LL   + 
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 64  RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
            +  TK   T LH+AA  G   +V  L+ +GA+VNA+     T L+ A + NH EVV+ L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
           ++ GA+ +  ++   T   +++  G+E++                 L IA +N       
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 164 -INTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAVQFGNSST 221
            +  N  +PD ++    TP  I      +N+  L+ +  +S   T + G++ +   +   
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 222 SVL 224
           +V+
Sbjct: 251 NVI 253



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 44/135 (32%), Positives = 75/135 (55%), Gaps = 1/135 (0%)

Query: 23  RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
           ++L+  GA    T   G +PLH+A++ G+     +LL  G   + +TK + TPLH AA  
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 82  GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
           GH  I E+LL HGA + AK    ++ +H A + +H + V LL++Y A++   +    T  
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342

Query: 142 DISIDNGNEDLAEIL 156
            ++   G+  +A++L
Sbjct: 343 HVAAHCGHHRVAKVL 357



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 63/198 (31%), Positives = 103/198 (52%), Gaps = 13/198 (6%)

Query: 13  AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           AA+    D VR+L+   A     T D L  +PLH+AA  GH+   +VLL  G   ++R  
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
              TPLH+A  + H  ++E+LLK GA ++A     +T LH A+   H  +V+ L++ GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
            +  +   +T   ++   G+ ++A+ L   +QN+   N ++ D  T +H A     IG  
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483

Query: 189 GVVNLTGLVSSENSSKAT 206
            +V L  L ++ N + AT
Sbjct: 484 NMVKLL-LENNANPNLAT 500



 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 56/162 (34%), Positives = 81/162 (50%), Gaps = 3/162 (1%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G      IL+ +GAP       G SP+H+AAQ  H     +LL+     D  T   
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA  GH  + +VLL  GA  N++ +   T LH A + NH  V+ELL+K GA + 
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP 171
             ++   T   ++   G+  + + L  + A  N  N   E+P
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 13/202 (6%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           A+R G    VR+L+  GA   T      +PLH AA+ GH   +E+LL  G    A+TK  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            +P+HMAA   H   V +LL++ A+++   +  +T LH A    H  V ++L+  GA  +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG-- 189
           +++    T   I+    +  + E+L       + T   S D VT    TP  +    G  
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL-------LKTG-ASIDAVTESGLTPLHVASFMGHL 417

Query: 190 --VVNLTGLVSSENSSKATDET 209
             V NL    +S N S    ET
Sbjct: 418 PIVKNLLQRGASPNVSNVKVET 439



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)

Query: 24  ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
           +L    +P  ++    +PLH+AA+ GH    + LL+     +A+ K D+TPLH AA  GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 84  ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
            ++V++LL++ A+ N       T LH A    H E V  L++  A     +K   T   +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
           +   G   +AE+L  + A  N    N  +P  V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 42/134 (31%), Positives = 71/134 (52%), Gaps = 5/134 (3%)

Query: 7   GKKLLEAAR-AGQDDEVR----ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
           GK  L A   A ++D+ R    +L  +  P      G +PLH+AA Y + +  ++LL  G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 62  VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
            S +   +   TPLH+A+  G+  +V +LL  GA +  K   ++T LH A  + H  + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 122 LLIKYGADVHTQSK 135
           +L+ +GA +  ++K
Sbjct: 290 ILLDHGAPIQAKTK 303



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 64/244 (26%), Positives = 101/244 (41%), Gaps = 11/244 (4%)

Query: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
           +S V +   L  AARAG  +  + L+ N A          +PLH AA+ GH +  ++LL 
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 60  AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
              + +  T    TPLH+AA EGH   V  LL+  A          T LH A ++    V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
            ELL++  A  +   K   T   +++ + N D+ ++L             SP +   +  
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603

Query: 180 TPQFIIGPGGVVNLT-GLVSSENSSKATDETGVSAVQF-GNSSTSVLATLAALAEASAPL 237
           TP  I      V +   L+    S+ A    GV+ +        + +  L    +A+  L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 238 SNSS 241
            N S
Sbjct: 664 GNKS 667



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 83/365 (22%), Positives = 154/365 (42%), Gaps = 42/365 (11%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G+     +L+   A P      G +PLH+A  + +    ++LL  G S  +     
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA +    +   LL++G   NA+ +  +T LH A +  H E+V LL+   A+ +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
             +K   T   +    G+  +A++L   +++ +       D  T    TP  +    G +
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVL---IKHGVMV-----DATTRMGYTPLHVASHYGNI 714

Query: 192 NLTG-LVSSENSSKATDETGVS----AVQFGNSSTSVLATLAALAEASAPLSNSSETPVV 246
            L   L+  +    A  + G S    A Q G+  T ++  L     +   +S+   TP+ 
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 247 ATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH--SIPTSGIGQPIIVTMPDG 304
             + +      D            +V+T  T  + + + H  S P + + + + V+  +G
Sbjct: 773 IAKRLGYISVTDVL----------KVVTDETSFVLVSDKHRMSFPET-VDEILDVSEDEG 821

Query: 305 QQVLTVPA-----TDIAEETVISEEPPAKRQCIEI-IENRVESA-------EIEEREALQ 351
           +++++  A      D+ EE  + +  P   Q +E     R+  A         EE+E   
Sbjct: 822 EELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQAS 881

Query: 352 KQLDE 356
           K+ DE
Sbjct: 882 KEYDE 886



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 39/115 (33%), Positives = 62/115 (53%)

Query: 42  LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
           LH+AA+     T  VLL+   + D  +K   TPLH+AA   + ++ ++LL  GA VN   
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236

Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
              +T LH A+   +  +V LL+  GA + T++K   T    +  NG+  ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 49/174 (28%), Positives = 75/174 (43%), Gaps = 30/174 (17%)

Query: 13  AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA AGQD+ VR L+  GA        G +PL++AAQ  H    + LL  G +++  T+  
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 72  RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
            TPL +A  +GH ++V  L+ +G                            D N   + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
              T LH A  + +  V +LL+  GA V+   +   T   I+   GN  +  +L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 92.0 bits (227), Expect = 8e-19
 Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)

Query: 13  AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G  + V +L++  A     +  G +PLHL AQ GH    +VL++ GV  DA T++ 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+A+  G+  +V+ LL+H ADVNAK  L  + LH A +  H ++V LL+K GA  +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
             S    T   I+   G   + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 60/198 (30%), Positives = 99/198 (50%), Gaps = 14/198 (7%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+  Q +  R L+  G     + + G +PLHLAAQ GH     +LL    + +   K  
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+ A EGH  + +VL+KHG  V+A   +  T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
            ++K   +    +   G+ D+  +L          N  SP+ V+    TP  I    G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 192 NLTGLVSSENSSKATDET 209
           ++T ++        TDET
Sbjct: 781 SVTDVL-----KVVTDET 793



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 59/192 (30%), Positives = 93/192 (48%), Gaps = 9/192 (4%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G  + V++L+ N A P      G +PLH+AA+ GH  T   LL    S+   TK  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA  G   + E+LL+  A  NA     +T LH A  HN+ ++V+LL+  G   H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
           + +    T   I+     ++  E+ +  +Q   + N ES     +   TP  +    G  
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAES-----VQGVTPLHLAAQEGHA 648

Query: 192 NLTGLVSSENSS 203
            +  L+ S+ ++
Sbjct: 649 EMVALLLSKQAN 660



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 62/200 (31%), Positives = 97/200 (48%), Gaps = 10/200 (5%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G     ++L+  GA P +    G +PLH+A +  H    E+LL+ G S DA T+  
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+A+  GH  IV+ LL+ GA  N  ++   T LH A    H EV + L++  A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIG-PGGV 190
            ++K  +T    +   G+ ++ ++L   ++N  N     P+  T    TP  I    G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516

Query: 191 VNLTGLVSSENSSKATDETG 210
             +  L+  E S     + G
Sbjct: 517 ETVLALLEKEASQACMTKKG 536



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 50/152 (32%), Positives = 81/152 (53%), Gaps = 4/152 (2%)

Query: 20  DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
           D V++L+  G +P +  W G +PLH+AA+         LL+ G S +A +    TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642

Query: 79  ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
           A EGHA +V +LL   A+ N  +   +T LH   +  H  V ++LIK+G  V   ++   
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702

Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPES 170
           T   ++   GN  L + L   +Q+Q + N ++
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKT 731



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 23/243 (9%)

Query: 5   DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
           D     L AAR+G  D+    + NG    T +  G + LHLA++ GH      LL   + 
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 64  RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
            +  TK   T LH+AA  G   +V  L+ +GA+VNA+     T L+ A + NH EVV+ L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
           ++ GA+ +  ++   T   +++  G+E++                 L IA +N       
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 164 -INTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAVQFGNSST 221
            +  N  +PD ++    TP  I      +N+  L+ +  +S   T + G++ +   +   
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 222 SVL 224
           +V+
Sbjct: 251 NVI 253



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 44/135 (32%), Positives = 75/135 (55%), Gaps = 1/135 (0%)

Query: 23  RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
           ++L+  GA    T   G +PLH+A++ G+     +LL  G   + +TK + TPLH AA  
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 82  GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
           GH  I E+LL HGA + AK    ++ +H A + +H + V LL++Y A++   +    T  
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342

Query: 142 DISIDNGNEDLAEIL 156
            ++   G+  +A++L
Sbjct: 343 HVAAHCGHHRVAKVL 357



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 63/198 (31%), Positives = 103/198 (52%), Gaps = 13/198 (6%)

Query: 13  AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           AA+    D VR+L+   A     T D L  +PLH+AA  GH+   +VLL  G   ++R  
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
              TPLH+A  + H  ++E+LLK GA ++A     +T LH A+   H  +V+ L++ GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
            +  +   +T   ++   G+ ++A+ L   +QN+   N ++ D  T +H A     IG  
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483

Query: 189 GVVNLTGLVSSENSSKAT 206
            +V L  L ++ N + AT
Sbjct: 484 NMVKLL-LENNANPNLAT 500



 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 56/162 (34%), Positives = 81/162 (50%), Gaps = 3/162 (1%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G      IL+ +GAP       G SP+H+AAQ  H     +LL+     D  T   
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA  GH  + +VLL  GA  N++ +   T LH A + NH  V+ELL+K GA + 
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP 171
             ++   T   ++   G+  + + L  + A  N  N   E+P
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 13/202 (6%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           A+R G    VR+L+  GA   T      +PLH AA+ GH   +E+LL  G    A+TK  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            +P+HMAA   H   V +LL++ A+++   +  +T LH A    H  V ++L+  GA  +
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG-- 189
           +++    T   I+    +  + E+L       + T   S D VT    TP  +    G  
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELL-------LKTG-ASIDAVTESGLTPLHVASFMGHL 417

Query: 190 --VVNLTGLVSSENSSKATDET 209
             V NL    +S N S    ET
Sbjct: 418 PIVKNLLQRGASPNVSNVKVET 439



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)

Query: 24  ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
           +L    +P  ++    +PLH+AA+ GH    + LL+     +A+ K D+TPLH AA  GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 84  ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
            ++V++LL++ A+ N       T LH A    H E V  L++  A     +K   T   +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
           +   G   +AE+L  + A  N    N  +P  V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 42/134 (31%), Positives = 71/134 (52%), Gaps = 5/134 (3%)

Query: 7   GKKLLEAAR-AGQDDEVR----ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
           GK  L A   A ++D+ R    +L  +  P      G +PLH+AA Y + +  ++LL  G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229

Query: 62  VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
            S +   +   TPLH+A+  G+  +V +LL  GA +  K   ++T LH A  + H  + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 122 LLIKYGADVHTQSK 135
           +L+ +GA +  ++K
Sbjct: 290 ILLDHGAPIQAKTK 303



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 64/244 (26%), Positives = 101/244 (41%), Gaps = 11/244 (4%)

Query: 1   MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
           +S V +   L  AARAG  +  + L+ N A          +PLH AA+ GH +  ++LL 
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 60  AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
              + +  T    TPLH+AA EGH   V  LL+  A          T LH A ++    V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
            ELL++  A  +   K   T   +++ + N D+ ++L             SP +   +  
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603

Query: 180 TPQFIIGPGGVVNLT-GLVSSENSSKATDETGVSAVQF-GNSSTSVLATLAALAEASAPL 237
           TP  I      V +   L+    S+ A    GV+ +        + +  L    +A+  L
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 238 SNSS 241
            N S
Sbjct: 664 GNKS 667



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 83/365 (22%), Positives = 154/365 (42%), Gaps = 42/365 (11%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G+     +L+   A P      G +PLH+A  + +    ++LL  G S  +     
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA +    +   LL++G   NA+ +  +T LH A +  H E+V LL+   A+ +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
             +K   T   +    G+  +A++L   +++ +       D  T    TP  +    G +
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVL---IKHGVMV-----DATTRMGYTPLHVASHYGNI 714

Query: 192 NLTG-LVSSENSSKATDETGVS----AVQFGNSSTSVLATLAALAEASAPLSNSSETPVV 246
            L   L+  +    A  + G S    A Q G+  T ++  L     +   +S+   TP+ 
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 247 ATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH--SIPTSGIGQPIIVTMPDG 304
             + +      D            +V+T  T  + + + H  S P + + + + V+  +G
Sbjct: 773 IAKRLGYISVTDVL----------KVVTDETSFVLVSDKHRMSFPET-VDEILDVSEDEG 821

Query: 305 QQVLTVPA-----TDIAEETVISEEPPAKRQCIEI-IENRVESA-------EIEEREALQ 351
           +++++  A      D+ EE  + +  P   Q +E     R+  A         EE+E   
Sbjct: 822 EELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQAS 881

Query: 352 KQLDE 356
           K+ DE
Sbjct: 882 KEYDE 886



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 39/115 (33%), Positives = 62/115 (53%)

Query: 42  LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
           LH+AA+     T  VLL+   + D  +K   TPLH+AA   + ++ ++LL  GA VN   
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236

Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
              +T LH A+   +  +V LL+  GA + T++K   T    +  NG+  ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 49/174 (28%), Positives = 75/174 (43%), Gaps = 30/174 (17%)

Query: 13  AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA AGQD+ VR L+  GA        G +PL++AAQ  H    + LL  G +++  T+  
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 72  RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
            TPL +A  +GH ++V  L+ +G                            D N   + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
              T LH A  + +  V +LL+  GA V+   +   T   I+   GN  +  +L
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 92.0 bits (227), Expect = 8e-19
 Identities = 53/154 (34%), Positives = 81/154 (52%)

Query: 6   LGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRD 65
           L ++LL AA  GQ + V  L+  GA       G +PLHLAA  GH    ++LL+AG   D
Sbjct: 10  LSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLD 69

Query: 66  ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
            +   D+T LH A   G+  I+  L+  G  ++ +D    TALH A+ H   +  +LL+K
Sbjct: 70  VQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK 129

Query: 126 YGADVHTQSKFCKTAFDISIDNGNEDLAEILQIA 159
            GA+V  ++K   TA  ++  N +     +L +A
Sbjct: 130 AGANVLAKNKAGNTALHLACQNSHSQSTRVLLLA 163



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 51/153 (33%), Positives = 78/153 (50%), Gaps = 1/153 (0%)

Query: 10  LLEAARAGQDDEVRILMANGAP-FTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
           L EA+  G     ++L+  GA     +  G + LHLA Q  H  +T VLL AG   D + 
Sbjct: 112 LHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKN 171

Query: 69  KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
               T LH+AA   H SI+ +LL     V+ K+    TALH A   NH++V ++L++ GA
Sbjct: 172 NAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGA 231

Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQ 161
           D    +   +T  + +  + N ++A +L  A Q
Sbjct: 232 DTTIVNNAGQTPLETARYHNNPEVALLLTKAPQ 264



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 46/126 (36%), Positives = 67/126 (53%), Gaps = 1/126 (0%)

Query: 42  LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
           L +AA  G       L+  G +R A TK  RTPLH+AA++GH  +V++LLK G D++ +D
Sbjct: 14  LLVAAYKGQTENVVQLINKG-ARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72

Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQ 161
               TALH AT   + E++  LI  G  +  Q K   TA   +  +G    A++L  A  
Sbjct: 73  DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132

Query: 162 NQINTN 167
           N +  N
Sbjct: 133 NVLAKN 138



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 35/119 (29%), Positives = 63/119 (52%)

Query: 38  GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
           G + LH A+ +G   + ++L++AG +  A+ K   T LH+A    H+    VLL  G+  
Sbjct: 108 GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 167

Query: 98  NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           + K+    T LH A  +NH  ++ LL+     VH +++   TA  ++    ++ +A+IL
Sbjct: 168 DLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKIL 226


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 55/153 (35%), Positives = 83/153 (54%), Gaps = 1/153 (0%)

Query: 5   DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
           D     L AARAG  D+V   +  G    T +  G + LHLAA+ GH    + LL  G S
Sbjct: 9   DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68

Query: 64  RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
            D+ TK   T LH+A+  G A +V+VL+K GA++NA+     T L+ A + NH +VV+ L
Sbjct: 69  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           ++ GA+  T ++   T   +++  G+     IL
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161



 Score = 82.0 bits (201), Expect = 8e-16
 Identities = 62/213 (29%), Positives = 100/213 (46%), Gaps = 12/213 (5%)

Query: 24  ILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
           +L+  GA P  T   G +PLH+AA+         LL  G   +  TK   TPLH+A+ EG
Sbjct: 593 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 652

Query: 83  HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
           H  +V +LL  GA+++      +T+LH A + +   V ++L K+GAD    +K   T   
Sbjct: 653 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLI 712

Query: 143 ISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPGGVVNLTGLVSSEN 201
           ++   GN  +   L   ++   N N ++ +  T +H A  Q   G   ++N+  L+    
Sbjct: 713 VACHYGNVKMVNFL---LKQGANVNAKTKNGYTPLHQAAQQ---GHTHIINV--LLQHGA 764

Query: 202 SSKATDETGVSAVQFGN--SSTSVLATLAALAE 232
              AT   G +A+         SV+ TL  + E
Sbjct: 765 KPNATTANGNTALAIAKRLGYISVVDTLKVVTE 797



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 1/155 (0%)

Query: 13  AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           A++ G  D V +L+  GA    +   G + LHLAAQ    +  ++L + G  +DA TK+ 
Sbjct: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 707

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPL +A   G+  +V  LLK GA+VNAK     T LH A +  H  ++ +L+++GA  +
Sbjct: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 767

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
             +    TA  I+   G   + + L++  +    T
Sbjct: 768 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 802



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 1/145 (0%)

Query: 13  AARAGQDDEVRILMAN-GAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G  D  ++L+    A  +    G +PLH+AA Y +     +LL  G S  A  K  
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA +    I   LL +GA+ N      +T LH A++  H ++V LL+  GA++H
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
             +K   T+  ++      ++A+IL
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADIL 693



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 57/186 (30%), Positives = 93/186 (50%), Gaps = 9/186 (4%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G     ++L+   A P      G +PLH+A +       E+L++ G S  A T+  
Sbjct: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TP+H+AA  GH +IV +LL++GA  +  ++   TALH A      EVV  L++ GA V 
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
            +++  +T   I+   G     EI+Q+ +Q+  +     PD  T +  TP  I    G V
Sbjct: 471 ARAREEQTPLHIASRLGK---TEIVQLLLQHMAH-----PDAATTNGYTPLHISAREGQV 522

Query: 192 NLTGLV 197
           ++  ++
Sbjct: 523 DVASVL 528



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 37/98 (37%), Positives = 60/98 (61%)

Query: 38  GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
           G +PLH+AA YG+ +   +LL  G + D   +   TPLH+A+  G+ ++V++LL  G  +
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271

Query: 98  NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSK 135
           +AK    +T LH A    H +VVELL++ GA +  ++K
Sbjct: 272 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 74/284 (26%), Positives = 125/284 (44%), Gaps = 28/284 (9%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G  + V +L+ NGA P  T+  G + LH+AA+ G       LLR G   DAR + +
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
           +TPLH+A+  G   IV++LL+H A  +A      T LH +      +V  +L++ GA   
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
             +K   T   ++   G+ D+A++L  + A  +    N  +P  V  H    +  +    
Sbjct: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL---- 592

Query: 190 VVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATE 249
                 L+    S  AT + G + +        + A    +  AS  L+  +ET +V  +
Sbjct: 593 -----LLLEKGASPHATAKNGYTPLH-------IAAKKNQMQIASTLLNYGAETNIVTKQ 640

Query: 250 EVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGI 293
            V         +      G   ++T++ D  +  N+H    SG+
Sbjct: 641 GVT-------PLHLASQEGHTDMVTLLLD--KGANIHMSTKSGL 675



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 60/226 (26%), Positives = 108/226 (47%), Gaps = 10/226 (4%)

Query: 13  AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G  +   +L+  GA    T   G +PLH+A++ G+ +  ++LL  G   DA+T+  
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH AA  GH  +VE+LL+ GA + A+    ++ LH A + +H E V+ L+++ A V 
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
             +    TA  ++   G+  + ++L     N        P+   ++  TP  I      +
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKRAN--------PNARALNGFTPLHIACKKNRI 390

Query: 192 NLTGLVSSENSS-KATDETGVSAVQFGNSSTSVLATLAALAEASAP 236
            +  L+    +S +A  E+G++ +        +   L  L   ++P
Sbjct: 391 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 56/206 (27%), Positives = 96/206 (46%), Gaps = 13/206 (6%)

Query: 13  AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G    V+ L+  G+   +    G + LH+A+  G     +VL++ G + +A+++  
Sbjct: 50  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPL+MAA E H  +V+ LL++GA+ +       T L  A +  H + V +L+    +  
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----END 165

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESP---DTVTIHAATPQFIIGPG 188
           T+ K    A  I+    +   A +L   +QN  N + +S    +  T    TP  I    
Sbjct: 166 TKGKVRLPALHIAARKDDTKSAALL---LQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 222

Query: 189 GVVNLTGLVSSENSSKATDETGVSAV 214
           G VN+  L+   N   A D T  + +
Sbjct: 223 GNVNVATLLL--NRGAAVDFTARNGI 246



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 42/155 (27%), Positives = 78/155 (50%), Gaps = 11/155 (7%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           L  A + G +  V IL+ N    T   +    LH+AA+     +  +LL+   + D ++K
Sbjct: 146 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 202

Query: 70  --VDRT------PLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
             V+RT      PLH+AA  G+ ++  +LL  GA V+      +T LH A++  +  +V+
Sbjct: 203 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262

Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           LL+  G  +  +++   T    +  +G++ + E+L
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 55/153 (35%), Positives = 83/153 (54%), Gaps = 1/153 (0%)

Query: 5   DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
           D     L AARAG  D+V   +  G    T +  G + LHLAA+ GH    + LL  G S
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 64  RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
            D+ TK   T LH+A+  G A +V+VL+K GA++NA+     T L+ A + NH +VV+ L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           ++ GA+  T ++   T   +++  G+     IL
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182



 Score = 82.0 bits (201), Expect = 8e-16
 Identities = 62/213 (29%), Positives = 100/213 (46%), Gaps = 12/213 (5%)

Query: 24  ILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
           +L+  GA P  T   G +PLH+AA+         LL  G   +  TK   TPLH+A+ EG
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673

Query: 83  HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
           H  +V +LL  GA+++      +T+LH A + +   V ++L K+GAD    +K   T   
Sbjct: 674 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLI 733

Query: 143 ISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPGGVVNLTGLVSSEN 201
           ++   GN  +   L   ++   N N ++ +  T +H A  Q   G   ++N+  L+    
Sbjct: 734 VACHYGNVKMVNFL---LKQGANVNAKTKNGYTPLHQAAQQ---GHTHIINV--LLQHGA 785

Query: 202 SSKATDETGVSAVQFGN--SSTSVLATLAALAE 232
              AT   G +A+         SV+ TL  + E
Sbjct: 786 KPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 1/155 (0%)

Query: 13  AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           A++ G  D V +L+  GA    +   G + LHLAAQ    +  ++L + G  +DA TK+ 
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPL +A   G+  +V  LLK GA+VNAK     T LH A +  H  ++ +L+++GA  +
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
             +    TA  I+   G   + + L++  +    T
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 823



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 1/145 (0%)

Query: 13  AARAGQDDEVRILMAN-GAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G  D  ++L+    A  +    G +PLH+AA Y +     +LL  G S  A  K  
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA +    I   LL +GA+ N      +T LH A++  H ++V LL+  GA++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
             +K   T+  ++      ++A+IL
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADIL 714



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 57/186 (30%), Positives = 93/186 (50%), Gaps = 9/186 (4%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G     ++L+   A P      G +PLH+A +       E+L++ G S  A T+  
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TP+H+AA  GH +IV +LL++GA  +  ++   TALH A      EVV  L++ GA V 
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
            +++  +T   I+   G     EI+Q+ +Q+  +     PD  T +  TP  I    G V
Sbjct: 492 ARAREEQTPLHIASRLGK---TEIVQLLLQHMAH-----PDAATTNGYTPLHISAREGQV 543

Query: 192 NLTGLV 197
           ++  ++
Sbjct: 544 DVASVL 549



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 37/98 (37%), Positives = 60/98 (61%)

Query: 38  GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
           G +PLH+AA YG+ +   +LL  G + D   +   TPLH+A+  G+ ++V++LL  G  +
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292

Query: 98  NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSK 135
           +AK    +T LH A    H +VVELL++ GA +  ++K
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 74/284 (26%), Positives = 125/284 (44%), Gaps = 28/284 (9%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G  + V +L+ NGA P  T+  G + LH+AA+ G       LLR G   DAR + +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
           +TPLH+A+  G   IV++LL+H A  +A      T LH +      +V  +L++ GA   
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
             +K   T   ++   G+ D+A++L  + A  +    N  +P  V  H    +  +    
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL---- 613

Query: 190 VVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATE 249
                 L+    S  AT + G + +        + A    +  AS  L+  +ET +V  +
Sbjct: 614 -----LLLEKGASPHATAKNGYTPLH-------IAAKKNQMQIASTLLNYGAETNIVTKQ 661

Query: 250 EVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGI 293
            V         +      G   ++T++ D  +  N+H    SG+
Sbjct: 662 GVT-------PLHLASQEGHTDMVTLLLD--KGANIHMSTKSGL 696



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 60/226 (26%), Positives = 108/226 (47%), Gaps = 10/226 (4%)

Query: 13  AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G  +   +L+  GA    T   G +PLH+A++ G+ +  ++LL  G   DA+T+  
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH AA  GH  +VE+LL+ GA + A+    ++ LH A + +H E V+ L+++ A V 
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
             +    TA  ++   G+  + ++L     N        P+   ++  TP  I      +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRAN--------PNARALNGFTPLHIACKKNRI 411

Query: 192 NLTGLVSSENSS-KATDETGVSAVQFGNSSTSVLATLAALAEASAP 236
            +  L+    +S +A  E+G++ +        +   L  L   ++P
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 56/206 (27%), Positives = 96/206 (46%), Gaps = 13/206 (6%)

Query: 13  AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G    V+ L+  G+   +    G + LH+A+  G     +VL++ G + +A+++  
Sbjct: 71  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPL+MAA E H  +V+ LL++GA+ +       T L  A +  H + V +L+    +  
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----END 186

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESP---DTVTIHAATPQFIIGPG 188
           T+ K    A  I+    +   A +L   +QN  N + +S    +  T    TP  I    
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALL---LQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243

Query: 189 GVVNLTGLVSSENSSKATDETGVSAV 214
           G VN+  L+   N   A D T  + +
Sbjct: 244 GNVNVATLLL--NRGAAVDFTARNGI 267



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 42/155 (27%), Positives = 78/155 (50%), Gaps = 11/155 (7%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           L  A + G +  V IL+ N    T   +    LH+AA+     +  +LL+   + D ++K
Sbjct: 167 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223

Query: 70  --VDRT------PLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
             V+RT      PLH+AA  G+ ++  +LL  GA V+      +T LH A++  +  +V+
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283

Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           LL+  G  +  +++   T    +  +G++ + E+L
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 55/153 (35%), Positives = 83/153 (54%), Gaps = 1/153 (0%)

Query: 5   DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
           D     L AARAG  D+V   +  G    T +  G + LHLAA+ GH    + LL  G S
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 64  RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
            D+ TK   T LH+A+  G A +V+VL+K GA++NA+     T L+ A + NH +VV+ L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           ++ GA+  T ++   T   +++  G+     IL
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182



 Score = 82.0 bits (201), Expect = 8e-16
 Identities = 62/213 (29%), Positives = 100/213 (46%), Gaps = 12/213 (5%)

Query: 24  ILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
           +L+  GA P  T   G +PLH+AA+         LL  G   +  TK   TPLH+A+ EG
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673

Query: 83  HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
           H  +V +LL  GA+++      +T+LH A + +   V ++L K+GAD    +K   T   
Sbjct: 674 HTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLI 733

Query: 143 ISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPGGVVNLTGLVSSEN 201
           ++   GN  +   L   ++   N N ++ +  T +H A  Q   G   ++N+  L+    
Sbjct: 734 VACHYGNVKMVNFL---LKQGANVNAKTKNGYTPLHQAAQQ---GHTHIINV--LLQHGA 785

Query: 202 SSKATDETGVSAVQFGN--SSTSVLATLAALAE 232
              AT   G +A+         SV+ TL  + E
Sbjct: 786 KPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 1/155 (0%)

Query: 13  AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           A++ G  D V +L+  GA    +   G + LHLAAQ    +  ++L + G  +DA TK+ 
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPL +A   G+  +V  LLK GA+VNAK     T LH A +  H  ++ +L+++GA  +
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
             +    TA  I+   G   + + L++  +    T
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 823



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 1/145 (0%)

Query: 13  AARAGQDDEVRILMAN-GAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G  D  ++L+    A  +    G +PLH+AA Y +     +LL  G S  A  K  
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA +    I   LL +GA+ N      +T LH A++  H ++V LL+  GA++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
             +K   T+  ++      ++A+IL
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADIL 714



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 57/186 (30%), Positives = 93/186 (50%), Gaps = 9/186 (4%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G     ++L+   A P      G +PLH+A +       E+L++ G S  A T+  
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TP+H+AA  GH +IV +LL++GA  +  ++   TALH A      EVV  L++ GA V 
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
            +++  +T   I+   G     EI+Q+ +Q+  +     PD  T +  TP  I    G V
Sbjct: 492 ARAREEQTPLHIASRLGK---TEIVQLLLQHMAH-----PDAATTNGYTPLHISAREGQV 543

Query: 192 NLTGLV 197
           ++  ++
Sbjct: 544 DVASVL 549



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 37/98 (37%), Positives = 60/98 (61%)

Query: 38  GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
           G +PLH+AA YG+ +   +LL  G + D   +   TPLH+A+  G+ ++V++LL  G  +
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292

Query: 98  NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSK 135
           +AK    +T LH A    H +VVELL++ GA +  ++K
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 74/284 (26%), Positives = 125/284 (44%), Gaps = 28/284 (9%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G  + V +L+ NGA P  T+  G + LH+AA+ G       LLR G   DAR + +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
           +TPLH+A+  G   IV++LL+H A  +A      T LH +      +V  +L++ GA   
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
             +K   T   ++   G+ D+A++L  + A  +    N  +P  V  H    +  +    
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL---- 613

Query: 190 VVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATE 249
                 L+    S  AT + G + +        + A    +  AS  L+  +ET +V  +
Sbjct: 614 -----LLLEKGASPHATAKNGYTPLH-------IAAKKNQMQIASTLLNYGAETNIVTKQ 661

Query: 250 EVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGI 293
            V         +      G   ++T++ D  +  N+H    SG+
Sbjct: 662 GVT-------PLHLASQEGHTDMVTLLLD--KGANIHMSTKSGL 696



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 60/226 (26%), Positives = 108/226 (47%), Gaps = 10/226 (4%)

Query: 13  AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G  +   +L+  GA    T   G +PLH+A++ G+ +  ++LL  G   DA+T+  
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH AA  GH  +VE+LL+ GA + A+    ++ LH A + +H E V+ L+++ A V 
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
             +    TA  ++   G+  + ++L     N        P+   ++  TP  I      +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRAN--------PNARALNGFTPLHIACKKNRI 411

Query: 192 NLTGLVSSENSS-KATDETGVSAVQFGNSSTSVLATLAALAEASAP 236
            +  L+    +S +A  E+G++ +        +   L  L   ++P
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 56/206 (27%), Positives = 96/206 (46%), Gaps = 13/206 (6%)

Query: 13  AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G    V+ L+  G+   +    G + LH+A+  G     +VL++ G + +A+++  
Sbjct: 71  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPL+MAA E H  +V+ LL++GA+ +       T L  A +  H + V +L+    +  
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----END 186

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESP---DTVTIHAATPQFIIGPG 188
           T+ K    A  I+    +   A +L   +QN  N + +S    +  T    TP  I    
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALL---LQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243

Query: 189 GVVNLTGLVSSENSSKATDETGVSAV 214
           G VN+  L+   N   A D T  + +
Sbjct: 244 GNVNVATLLL--NRGAAVDFTARNGI 267



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 42/155 (27%), Positives = 78/155 (50%), Gaps = 11/155 (7%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           L  A + G +  V IL+ N    T   +    LH+AA+     +  +LL+   + D ++K
Sbjct: 167 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223

Query: 70  --VDRT------PLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
             V+RT      PLH+AA  G+ ++  +LL  GA V+      +T LH A++  +  +V+
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283

Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           LL+  G  +  +++   T    +  +G++ + E+L
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 53/141 (37%), Positives = 73/141 (51%), Gaps = 1/141 (0%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
           LL AA AG+   +R L+A GA     D  G + L LAA  G     EVLL  G     R 
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266

Query: 69  KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
           +  R+ LH AA+ GH   V++L+  GA+V+A+D L +T LH A+   H EV   L+  GA
Sbjct: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGA 326

Query: 129 DVHTQSKFCKTAFDISIDNGN 149
            V       KT   ++ + G+
Sbjct: 327 QVDATGWLRKTPLHLAAERGH 347



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 48/129 (37%), Positives = 68/129 (52%), Gaps = 1/129 (0%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G+  ++ +L+ +GA P   D  G S LH AA  GH    ++L+  G   DAR  + 
Sbjct: 243 AAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLG 302

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH A+ EGH  +   LL  GA V+A   L+ T LH A E  H   V LL+  GA   
Sbjct: 303 LTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPT 362

Query: 132 TQSKFCKTA 140
            ++++ + A
Sbjct: 363 LRTQWAEVA 371



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 37/78 (47%), Positives = 45/78 (57%)

Query: 57  LLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNH 116
           LLR G S + R    RTPLH+A   GHA +V +LL+ GA V A D    TALH A  H H
Sbjct: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119

Query: 117 QEVVELLIKYGADVHTQS 134
             V ELL++ GA    +S
Sbjct: 120 SRVAELLLQRGASAAARS 137



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 47/121 (38%), Positives = 59/121 (48%), Gaps = 5/121 (4%)

Query: 13  AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           A   G    VR+L+  GAP    D  G + LH AA +GH    E+LL+ G S  AR+   
Sbjct: 81  AVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTG 140

Query: 72  RTPLHMAASEGHASIVEVLLKHG----ADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
            TPLH AA+ GH  +   LL+      A   A+D    TA HWA       V+ELL   G
Sbjct: 141 LTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGG 200

Query: 128 A 128
           A
Sbjct: 201 A 201



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 42/117 (35%), Positives = 57/117 (48%), Gaps = 1/117 (0%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
           LL+A   G    V  L+  GA     D  G +PLHLA   GH     +LL+ G    A  
Sbjct: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104

Query: 69  KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
           +  RT LH AA  GH+ + E+LL+ GA   A+    +T LHWA    H  +   L++
Sbjct: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLE 161



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 46/144 (31%), Positives = 65/144 (45%), Gaps = 6/144 (4%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR 72
           AA  G+   + +L A GA           L +AA  G  +    LL  G   DAR     
Sbjct: 184 AAAGGRLAVLELLAAGGAGLD------GALLVAAAAGRGAALRFLLARGARVDARDGAGA 237

Query: 73  TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
           T L +AA+ G +  +EVLL HGAD   +D    +ALH A    H   V+LL+  GA+V  
Sbjct: 238 TALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDA 297

Query: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
           +     T    +   G+ ++A  L
Sbjct: 298 RDTLGLTPLHHASREGHVEVAGCL 321



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 28/82 (34%), Positives = 41/82 (50%)

Query: 75  LHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQS 134
           L  A   G A +V  LL+ GA V  +D    T LH A    H  +V LL++ GA V    
Sbjct: 45  LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104

Query: 135 KFCKTAFDISIDNGNEDLAEIL 156
           +  +TA   +  +G+  +AE+L
Sbjct: 105 RAGRTALHEAAWHGHSRVAELL 126


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 60/188 (31%), Positives = 91/188 (48%), Gaps = 6/188 (3%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G     ++L+   A P      G +PLH+A +       E+LL+ G S  A T+  
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TP+H+AA  GH +IV  L+ HGA  N  ++   TALH A      EVV  L++ GA V 
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTI---HAATPQFIIG 186
            ++K  +T   IS   G  D+ + L  Q A  N   T+  +P  ++    H     F++ 
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLD 553

Query: 187 PGGVVNLT 194
            G  +++T
Sbjct: 554 HGASLSIT 561



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 50/153 (32%), Positives = 80/153 (52%), Gaps = 1/153 (0%)

Query: 5   DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
           D     L AARAG  ++    + NG      +  G + LHLA++ GH      LL+   +
Sbjct: 40  DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 99

Query: 64  RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
            DA TK   T LH+A+  G A +V+VL+ +GA+VNA+     T L+ A + NH EVV+ L
Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159

Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           +  GA     ++   T   +++  G++ +  +L
Sbjct: 160 LDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 52/155 (33%), Positives = 79/155 (50%), Gaps = 1/155 (0%)

Query: 13  AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G  D V +L+   A    ++  G +PLHLAAQ    +  EVL+  G   DA+TK+ 
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+    G+  IV  LL+H A VNAK     T LH A +  H  ++ +L++  A  +
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
             +    TA  I+   G   + + L+I  +  + T
Sbjct: 791 ELTVNGNTALGIARRLGYISVVDTLKIVTEETMTT 825



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 71/288 (24%), Positives = 127/288 (44%), Gaps = 28/288 (9%)

Query: 24  ILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
           +L+  GA P      G +PLH+AA+         LL  G   +A T+     +H+AA EG
Sbjct: 616 LLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEG 675

Query: 83  HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
           H  +V +LL   A+VN  +   +T LH A + +   V E+L+  GA V  Q+K   T   
Sbjct: 676 HVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLH 735

Query: 143 ISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPGGVVNLTGLVSSEN 201
           +    GN    +I+   +Q+    N ++ +  T +H A  Q      G  ++  ++   N
Sbjct: 736 VGCHYGN---IKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQ------GHTHIINVLLQNN 786

Query: 202 SSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAI 261
           +S   +E  V+    GN++  +   L  ++          +T  + TEE +T  +V    
Sbjct: 787 AS--PNELTVN----GNTALGIARRLGYISVV--------DTLKIVTEETMTTTTVTEKH 832

Query: 262 QQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLT 309
           +  V     +V+ +  D ++  N   + + G     I  + +G+  +T
Sbjct: 833 KMNVPETMNEVLDMSDDEVRKANAPEMLSDG---EYISDVEEGEDAMT 877



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 50/145 (34%), Positives = 77/145 (53%), Gaps = 1/145 (0%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G  + V  LM +GA P TT+  G + LH+AA+ G       L++ G   +A+ K D
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
           +TPLH++A  G A IV+ LL+ GA  NA      T LH +    H++V   L+ +GA + 
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
             +K   T   ++   G  ++A +L
Sbjct: 560 ITTKKGFTPLHVAAKYGKLEVANLL 584



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 65/232 (28%), Positives = 102/232 (43%), Gaps = 11/232 (4%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR+GQ + VR L+ +GA          +PLH++A+ G     + LL+ G S +A T   
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH++A EGH  +   LL HGA ++       T LH A ++   EV  LL++  A   
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
              K   T   ++    N+ +A +L             SP     +  TP  I      +
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLL--------DQGASPHAAAKNGYTPLHIAAKKNQM 644

Query: 192 NL-TGLVSSENSSKATDETGVSAVQFGNSSTSV-LATLAALAEASAPLSNSS 241
           ++ T L+     + A    G+++V        V + +L     A+  LSN S
Sbjct: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS 696



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 59/199 (29%), Positives = 97/199 (48%), Gaps = 12/199 (6%)

Query: 14  ARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR 72
           AR+G +  V +L+   AP  +    G SPLH+A Q  H +  ++LL+  V  D  T    
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL 368

Query: 73  TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
           T LH+AA  GH  + +VLL   A+ NAK +   T LH A + N  +V+ELL+K+GA +  
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428

Query: 133 QSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG--- 189
            ++   T   ++   G+ ++         +Q+  +  SP+T  +   T   +    G   
Sbjct: 429 VTESGLTPIHVAAFMGHVNIV--------SQLMHHGASPNTTNVRGETALHMAARSGQAE 480

Query: 190 VVNLTGLVSSENSSKATDE 208
           VV       ++  +KA D+
Sbjct: 481 VVRYLVQDGAQVEAKAKDD 499



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 43/143 (30%), Positives = 80/143 (55%), Gaps = 4/143 (2%)

Query: 38  GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
           G +PLH+AA YG+ +   +LL    + D   + D TPLH+A+  G+A++V++LL  GA +
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294

Query: 98  NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
           +AK    +T LH      H++VVE+L+   A + +++K   +   ++      D    +Q
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQG---DHLNCVQ 351

Query: 158 IAMQNQINTNPESPDTVT-IHAA 179
           + +Q+ +  +  + D +T +H A
Sbjct: 352 LLLQHNVPVDDVTNDYLTALHVA 374



 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 46/145 (31%), Positives = 74/145 (51%), Gaps = 1/145 (0%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA+ G+ +   +L+   A P      G +PLH+AA Y +     +LL  G S  A  K  
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH+AA +    I   LL++GAD NA     + ++H A +  H ++V LL+   A+V+
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691

Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
             +K   T   ++      ++AE+L
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVL 716



 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 48/176 (27%), Positives = 89/176 (50%), Gaps = 9/176 (5%)

Query: 40  SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNA 99
           +PLH+A++ G+ +  ++LL  G   DA+T+   TPLH  A  GH  +VE+LL   A + +
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329

Query: 100 KDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIA 159
           K    ++ LH AT+ +H   V+LL+++   V   +    TA  ++   G+  +A++L   
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389

Query: 160 MQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSS-KATDETGVSAV 214
             N        P+   ++  TP  I      + +  L+    +S +A  E+G++ +
Sbjct: 390 KAN--------PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPI 437



 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 66/261 (25%), Positives = 113/261 (43%), Gaps = 18/261 (6%)

Query: 13  AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           A++ G  + V++L+  GA     T D  G +PLH  A+ GH    E+LL       ++TK
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRD--GLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
              +PLHMA    H + V++LL+H   V+      +TALH A    H +V ++L+   A+
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392

Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
            + ++    T   I+       + E+L          +  S   VT    TP  +    G
Sbjct: 393 PNAKALNGFTPLHIACKKNRIKVMELLL--------KHGASIQAVTESGLTPIHVAAFMG 444

Query: 190 VVNLTGLV----SSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPV 245
            VN+   +    +S N++    ET +        +  V   +   A+  A  +   +TP+
Sbjct: 445 HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK-AKDDQTPL 503

Query: 246 VATEEVVTAESVDGAIQQVVS 266
             +  +  A+ V   +QQ  S
Sbjct: 504 HISARLGKADIVQQLLQQGAS 524



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 41/147 (27%), Positives = 72/147 (48%), Gaps = 3/147 (2%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           L  A + G D  V +L+ N    T   +    LH+AA+        +LL+   + D  +K
Sbjct: 177 LAVALQQGHDQVVSLLLEND---TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK 233

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
              TPLH+AA  G+ ++  +LL   A V+      +T LH A++  +  +V+LL+  GA 
Sbjct: 234 SGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAK 293

Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEIL 156
           +  +++   T       +G+E + E+L
Sbjct: 294 IDAKTRDGLTPLHCGARSGHEQVVEML 320



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 51/172 (29%), Positives = 80/172 (46%), Gaps = 14/172 (8%)

Query: 38  GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
           G + LH+A+  G     +VL+  G + +A+++   TPL+MAA E H  +V+ LL +GA  
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166

Query: 98  NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
           +       T L  A +  H +VV LL+    +  T+ K    A  I+    +   A +L 
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLL----ENDTKGKVRLPALHIAARKDDTKAAALL- 221

Query: 158 IAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSSKATDET 209
             +QN  N + ES         TP  I    G +N+  L+   N + A D T
Sbjct: 222 --LQNDNNADVESKS-----GFTPLHIAAHYGNINVATLLL--NRAAAVDFT 264


>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 54/147 (36%), Positives = 78/147 (53%), Gaps = 3/147 (2%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWLGTS-PLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  G+ D + +L+ +GA         + PLHLA Q GH+   + LL +    + +    
Sbjct: 751 AALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSG 810

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPL  A S GH  +V +LL+HGA +NA +    TALH A    H  VVELL+ +GA V 
Sbjct: 811 NTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870

Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
             +K  +TA D +    N  + E+LQ+
Sbjct: 871 VLNKRQRTAVDCA--EQNSKIMELLQV 895



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 40/119 (33%), Positives = 64/119 (53%)

Query: 38  GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
           G+SPLH+AA +G      +LL+ G +  AR      PLH+A  +GH  +V+ LL   A  
Sbjct: 744 GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 803

Query: 98  NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           N KD+   T L +A    H E+V LL+++GA ++  +    TA   ++   +  + E+L
Sbjct: 804 NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELL 862



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 55/201 (27%), Positives = 96/201 (47%), Gaps = 11/201 (5%)

Query: 13  AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AA  GQ   + +L++ GA    TD+ G +PLHLA Q G+ S T +LL    S + +    
Sbjct: 470 AAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNG 529

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKM---TALHWATEHNHQEVVELLIKYGA 128
            TPLH+A + GH   V+ L+ +  +    D+      T LH A    +Q V+E L++ GA
Sbjct: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589

Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPG 188
               Q++  +T    ++++    + E   ++ + +   + E+P        +PQ  +   
Sbjct: 590 STEIQNRLKETPLKCALNSKILSVMEAYHLSFERR-QKSSEAP------VQSPQRSVDSI 642

Query: 189 GVVNLTGLVSSENSSKATDET 209
              + T   SS ++S   +ET
Sbjct: 643 SQESSTSSFSSMSASSRQEET 663



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 33/99 (33%), Positives = 53/99 (53%)

Query: 31  PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVL 90
           PF+ D  G +PLH+AA  G  S  ++L+  G   +A      TPLH+A  +G+ S+  +L
Sbjct: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515

Query: 91  LKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
           L + A    +D    T LH A  + H++ V+ L+ Y  +
Sbjct: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE 554



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 3/94 (3%)

Query: 63  SRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVEL 122
           SRD R     TPLH+AA  G AS++++L+  GA VNA D    T LH A +  +Q V  L
Sbjct: 458 SRDDR---GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLL 514

Query: 123 LIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           L+ Y A    Q     T   ++   G+ED  + L
Sbjct: 515 LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKAL 548



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 43/184 (23%), Positives = 84/184 (45%), Gaps = 7/184 (3%)

Query: 60  AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
           +G+  +  ++   +PLH+AA  G A ++ +LLKHGA+  A++  +   LH A +  H +V
Sbjct: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792

Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
           V+ L+   A  + +     T    +   G+ +L  +L +     IN +    +T    A 
Sbjct: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALL-LQHGASINASNNKGNTALHEAV 851

Query: 180 TPQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSN 239
             + +     VV L  L+    S +  ++   +AV     ++ ++  L  +    A L +
Sbjct: 852 IEKHVF----VVEL--LLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDD 905

Query: 240 SSET 243
            +ET
Sbjct: 906 VAET 909


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 57/160 (35%), Positives = 78/160 (48%), Gaps = 29/160 (18%)

Query: 37  LGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGAD 96
           L  +PLH+AA+ GH ST  +LL  G  ++A T    T LH+AA  GH + V++L++  AD
Sbjct: 636 LAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKAD 695

Query: 97  VNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           V A+  L  TALH A  H H EVVE L+   ADV              ID  +E     L
Sbjct: 696 VLARGPLNQTALHLAAAHGHSEVVEELV--SADV--------------IDLFDEQGLSAL 739

Query: 157 QIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGL 196
            +A Q +             HA T + ++  G  +NL  L
Sbjct: 740 HLAAQGR-------------HAQTVETLLRHGAHINLQSL 766



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 56/164 (34%), Positives = 80/164 (48%), Gaps = 16/164 (9%)

Query: 13  AARAGQDDEVRILMANGAPFTTD----WLGTSPLHLAAQYGHYSTTEVLLRA-GVSRDAR 67
           A + GQ++ VRIL+  G   +      WL   PLH AA  GH    ++L +  GVS +A+
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWL---PLHYAAWQGHLPIVKLLAKQPGVSVNAQ 600

Query: 68  TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
           T   RTPLH+AA  GH  +  +L+   +DVN   +L  T LH A E  H     LL+  G
Sbjct: 601 TLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG 660

Query: 128 ADVHTQSKFCKTAFDISIDNGN--------EDLAEILQIAMQNQ 163
           A     +    TA  ++  NG+        E+ A++L     NQ
Sbjct: 661 AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQ 704



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 43/119 (36%), Positives = 64/119 (53%)

Query: 38  GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
           G +PLHLAAQ GHY    +L+      +  + + +TPLH+AA  GH S   +LL  GA  
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGK 663

Query: 98  NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
            A      TALH A  + H   V+LL++  ADV  +    +TA  ++  +G+ ++ E L
Sbjct: 664 EAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL 722



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 55/179 (30%), Positives = 90/179 (50%), Gaps = 5/179 (2%)

Query: 4   VDLGKKLLE-AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
           +D G  LL  A  AGQ++  + L+ N A P  ++  G++PLH+A +       E+LL   
Sbjct: 435 LDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK 494

Query: 62  VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
           +S +A+ +   T LH AA  G  S   +LL+  A VN  D    T +H A +H  + +V 
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554

Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAA 179
           +L++ G DV  Q K        +   G+  + ++L  A Q  ++ N ++ D  T +H A
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL--AKQPGVSVNAQTLDGRTPLHLA 611



 Score = 32.3 bits (72), Expect = 0.76
 Identities = 21/49 (42%), Positives = 24/49 (48%)

Query: 13  AARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
           AA  G  + V  L++       D  G S LHLAAQ  H  T E LLR G
Sbjct: 710 AAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG 758


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 50/143 (34%), Positives = 77/143 (53%), Gaps = 1/143 (0%)

Query: 10   LLEAARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
            L  AA  G+ +   +L+ +GA  + T+  G  PL  AA+ GH+    +LL  G   +   
Sbjct: 1075 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD 1134

Query: 69   KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
            K  RTPL +AA EGH S VE LL  GA +++ D   ++AL WA    H+ VV+ L++ GA
Sbjct: 1135 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA 1194

Query: 129  DVHTQSKFCKTAFDISIDNGNED 151
             +    K  +T  D++   G+ +
Sbjct: 1195 AIDQTDKNGRTPLDLAAFYGDAE 1217



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 40/117 (34%), Positives = 59/117 (50%), Gaps = 1/117 (0%)

Query: 13   AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
            AAR G    VR+L+  G     +D  G +PL +AA  GH ST E LL  G +  +  K  
Sbjct: 1111 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1170

Query: 72   RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
             + L  A  +GH ++V+ L++ GA ++  D    T L  A  +   E V  L++ GA
Sbjct: 1171 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1227



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 57/200 (28%), Positives = 84/200 (42%), Gaps = 17/200 (8%)

Query: 6    LGKKLLEAARAGQDDEVRILMA---------NGAPFTTDWLGTSPLHLAAQYGHYSTTEV 56
            L + L  AA  G    V+ L+          NG    T W G + L  AA  G     E+
Sbjct: 1033 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTD--TLW-GETALTAAAGRGKLEVCEL 1089

Query: 57   LLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNH 116
            LL  G +     +    PL  AA +GH  IV +LL+ G DVN  D    T L  A    H
Sbjct: 1090 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1149

Query: 117  QEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP-DT 173
               VE L+  GA + +  K   +A   +   G+  + + L  + A  +Q + N  +P D 
Sbjct: 1150 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1209

Query: 174  VTIH--AATPQFIIGPGGVV 191
               +  A T  +++  G V+
Sbjct: 1210 AAFYGDAETVLYLVEKGAVI 1229



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 40/120 (33%), Positives = 56/120 (46%), Gaps = 1/120 (0%)

Query: 10   LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
            L+ AA  G    V  L++ GA  ++ D  G S L  A   GH +  + L+  G + D   
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1200

Query: 69   KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
            K  RTPL +AA  G A  V  L++ GA +   D   M  L  A    +  VV  L++ GA
Sbjct: 1201 KNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 13/149 (8%)

Query: 36   WLGTSPLHLAAQYG--------HYSTTEVLLRAGVSRDARTKV-DRTPLHMAASE-GHAS 85
            W+G S   L+A           +   + +L+  G + + RT+V +  P+    S  GH  
Sbjct: 882  WIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEE 941

Query: 86   IVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISI 145
            +V +LL+ GA ++      MTAL +A    H ++V LL K G  V    K  + A   S 
Sbjct: 942  VVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSA 1001

Query: 146  DNGNEDLAEILQIAMQNQINTNPESPDTV 174
              G+ D   ILQ  +  + +  P  P T+
Sbjct: 1002 LRGHGD---ILQYLLTCEWSPGPPQPGTL 1027



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 30/105 (28%), Positives = 50/105 (47%), Gaps = 3/105 (2%)

Query: 23   RILMANGAP--FTTDWLGTSP-LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAA 79
            R+L+  GA   + T+ L  +P L + +  GH     +LL  G   D  ++   T L  AA
Sbjct: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968

Query: 80   SEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLI 124
            + GH  +V +L K G  V+  D     AL  +    H ++++ L+
Sbjct: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1013


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 50/143 (34%), Positives = 77/143 (53%), Gaps = 1/143 (0%)

Query: 10   LLEAARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
            L  AA  G+ +   +L+ +GA  + T+  G  PL  AA+ GH+    +LL  G   +   
Sbjct: 1083 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD 1142

Query: 69   KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
            K  RTPL +AA EGH S VE LL  GA +++ D   ++AL WA    H+ VV+ L++ GA
Sbjct: 1143 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA 1202

Query: 129  DVHTQSKFCKTAFDISIDNGNED 151
             +    K  +T  D++   G+ +
Sbjct: 1203 AIDQTDKNGRTPLDLAAFYGDAE 1225



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 40/117 (34%), Positives = 59/117 (50%), Gaps = 1/117 (0%)

Query: 13   AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
            AAR G    VR+L+  G     +D  G +PL +AA  GH ST E LL  G +  +  K  
Sbjct: 1119 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEG 1178

Query: 72   RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
             + L  A  +GH ++V+ L++ GA ++  D    T L  A  +   E V  L++ GA
Sbjct: 1179 LSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGA 1235



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 57/200 (28%), Positives = 84/200 (42%), Gaps = 17/200 (8%)

Query: 6    LGKKLLEAARAGQDDEVRILMA---------NGAPFTTDWLGTSPLHLAAQYGHYSTTEV 56
            L + L  AA  G    V+ L+          NG    T W G + L  AA  G     E+
Sbjct: 1041 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTD--TLW-GETALTAAAGRGKLEVCEL 1097

Query: 57   LLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNH 116
            LL  G +     +    PL  AA +GH  IV +LL+ G DVN  D    T L  A    H
Sbjct: 1098 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1157

Query: 117  QEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP-DT 173
               VE L+  GA + +  K   +A   +   G+  + + L  + A  +Q + N  +P D 
Sbjct: 1158 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1217

Query: 174  VTIH--AATPQFIIGPGGVV 191
               +  A T  +++  G V+
Sbjct: 1218 AAFYGDAETVLYLVEKGAVI 1237



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 40/120 (33%), Positives = 56/120 (46%), Gaps = 1/120 (0%)

Query: 10   LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
            L+ AA  G    V  L++ GA  ++ D  G S L  A   GH +  + L+  G + D   
Sbjct: 1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1208

Query: 69   KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
            K  RTPL +AA  G A  V  L++ GA +   D   M  L  A    +  VV  L++ GA
Sbjct: 1209 KNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 13/149 (8%)

Query: 36   WLGTSPLHLAAQYG--------HYSTTEVLLRAGVSRDARTKV-DRTPLHMAASE-GHAS 85
            W+G S   L+A           +   + +L+  G + + RT+V +  P+    S  GH  
Sbjct: 890  WIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEE 949

Query: 86   IVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISI 145
            +V +LL+ GA ++      MTAL +A    H ++V LL K G  V    K  + A   S 
Sbjct: 950  VVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSA 1009

Query: 146  DNGNEDLAEILQIAMQNQINTNPESPDTV 174
              G+ D   ILQ  +  + +  P  P T+
Sbjct: 1010 LRGHGD---ILQYLLTCEWSPGPPQPGTL 1035



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 30/105 (28%), Positives = 50/105 (47%), Gaps = 3/105 (2%)

Query: 23   RILMANGAP--FTTDWLGTSP-LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAA 79
            R+L+  GA   + T+ L  +P L + +  GH     +LL  G   D  ++   T L  AA
Sbjct: 917  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976

Query: 80   SEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLI 124
            + GH  +V +L K G  V+  D     AL  +    H ++++ L+
Sbjct: 977  AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1021


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 49/138 (35%), Positives = 73/138 (52%), Gaps = 1/138 (0%)

Query: 13  AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G  D  ++L + G+ P   D    +PLH AA +G+YS  + L  AG + + + +  
Sbjct: 452 AARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREG 511

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPL  A++ G+  IVE L +HGAD+NA D     ALH A      EV++ L+  G  V 
Sbjct: 512 ETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVD 571

Query: 132 TQSKFCKTAFDISIDNGN 149
            Q +   T   ++  +GN
Sbjct: 572 YQDRHGNTPLHVACKDGN 589



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 1/134 (0%)

Query: 13  AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           AAR G  D ++ L  N  P    D  G   LH+AA+YGH    ++L   G + + + K +
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE 478

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
            TPLH AA  G+ S+ + L + G +VN K+    T L  A+   + ++VE L ++GAD++
Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLN 538

Query: 132 TQSKFCKTAFDISI 145
              K    A  +++
Sbjct: 539 ACDKDGHIALHLAV 552



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 42/148 (28%), Positives = 74/148 (50%), Gaps = 1/148 (0%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
           LL AA  G    +++L+  G+     D  G++ ++ AA++GH  T + L       D + 
Sbjct: 383 LLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKD 442

Query: 69  KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
           K     LH+AA  GHA + ++L   G++ N +D  + T LH A  H +  V + L + G 
Sbjct: 443 KSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGC 502

Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           +V+ +++  +T    +   G  D+ E L
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVECL 530



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 45/148 (30%), Positives = 67/148 (45%), Gaps = 1/148 (0%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
           LL A+  G  D V  L  +GA     D  G   LHLA +       + LL  G   D + 
Sbjct: 515 LLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQD 574

Query: 69  KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
           +   TPLH+A  +G+  IV  L +   +++  +    T LH A  +   +VV  L   GA
Sbjct: 575 RHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGA 634

Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEIL 156
            V   +   KTA D++    +E +A +L
Sbjct: 635 SVEALTTDGKTAEDLARSEQHEHVAGLL 662



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 39/120 (32%), Positives = 54/120 (45%), Gaps = 1/120 (0%)

Query: 13  AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
           A R  Q + ++ L++ G      D  G +PLH+A + G+      L  A  + D   K  
Sbjct: 551 AVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYG 610

Query: 72  RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
           RTPLH+AA+ G   +V  L   GA V A      TA   A    H+ V  LL +   D H
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTH 670



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 33/119 (27%), Positives = 60/119 (50%)

Query: 38  GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
           GT PL +AA  G+    ++L++ G   D + K     ++ AA  GH   ++ L ++   +
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPL 438

Query: 98  NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           + KD     ALH A  + H +V +LL  +G++ + Q K  +T    +  +G   +A+ L
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497


>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
          Length = 360

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 47/129 (36%), Positives = 67/129 (51%), Gaps = 1/129 (0%)

Query: 45  AAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLK 104
           AA  G     E  L  G S D   +  RT LH A+ EGH  I+E LL +GA V+ +D L 
Sbjct: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214

Query: 105 MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQI 164
            TA+HWA    H EVV+LL  +GAD + + K   T   +++  G  ++ E   +++  +I
Sbjct: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF-LSLGLEI 273

Query: 165 NTNPESPDT 173
           N      DT
Sbjct: 274 NARDREGDT 282



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 46/135 (34%), Positives = 71/135 (52%), Gaps = 1/135 (0%)

Query: 10  LLEAARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
           L  A+  G  + +  L+ NGA     D L  + +H A + GH    ++L   G   + R 
Sbjct: 185 LHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRD 244

Query: 69  KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
           K+  TPLH+A   G   IVE  L  G ++NA+D    TALH A   N  ++++LL+ +GA
Sbjct: 245 KLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGA 304

Query: 129 DVHTQSKFCKTAFDI 143
           D+ T++   KT  D+
Sbjct: 305 DMMTKNLAGKTPTDL 319



 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 45/158 (28%), Positives = 76/158 (48%), Gaps = 1/158 (0%)

Query: 11  LEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           L+AA  G+   +   +A+G    T D    + LH A+  GH    E LL  G + D + +
Sbjct: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
           +D T +H A   GH  +V++L  HGAD N +D L  T LH A      E+VE  +  G +
Sbjct: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE 272

Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTN 167
           ++ + +   TA   ++      + ++L +   + +  N
Sbjct: 273 INARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKN 310



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 28/88 (31%), Positives = 43/88 (48%)

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
           VD      AA EG   ++E  L  G   +  D  + TALH A+   H E++E L+  GA 
Sbjct: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206

Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQ 157
           V  Q +   TA   +   G+ ++ ++LQ
Sbjct: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQ 234


>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
           isoform b [Homo sapiens]
          Length = 445

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 53/166 (31%), Positives = 82/166 (49%), Gaps = 9/166 (5%)

Query: 38  GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
           G   LHLAA  GH+   ++LL AG   +A T  + TPL +A   G   ++ +LL+HGA+V
Sbjct: 6   GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65

Query: 98  N-AKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           N +  M    +LH A+   + E+++LL++ GA+   Q  F  T   ++   G     E L
Sbjct: 66  NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK---LESL 122

Query: 157 QIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENS 202
            I + +  N N ++ D      ATP FI    G      L+ S  +
Sbjct: 123 SILISSGANVNCQALD-----KATPLFIAAQEGHTKCVELLLSSGA 163



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 2/122 (1%)

Query: 10  LLEAARAGQDDEVRILMANGAPF--TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
           L  A   GQ D +R+L+ +GA    +    G + LH A+   +    ++LLR G +++ +
Sbjct: 43  LFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQ 102

Query: 68  TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
                TPL +AA  G    + +L+  GA+VN + + K T L  A +  H + VELL+  G
Sbjct: 103 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 162

Query: 128 AD 129
           AD
Sbjct: 163 AD 164



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 3/128 (2%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTTDWLG-TSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
           L  AA+ G+ + + IL+++GA      L   +PL +AAQ GH    E+LL +G   D   
Sbjct: 110 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYC 169

Query: 69  KVD--RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
             D  + P+H AA  GH  I+++L+          + K++ ++ A    H++ +E+L++ 
Sbjct: 170 NEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRN 229

Query: 127 GADVHTQS 134
           G     Q+
Sbjct: 230 GYSPDAQA 237



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 35/137 (25%), Positives = 68/137 (49%), Gaps = 10/137 (7%)

Query: 4   VDLGKKLLEAARAGQDDEVRILMANGAP---FTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
           +D    L  AA+ G    V +L+++GA    +  +     P+H AAQ GH    ++L+  
Sbjct: 137 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL 196

Query: 61  GVSRDARTKVDR-TPLHMAASEGHASIVEVLLKHGADVNAKDML-----KMTALHWATEH 114
             +R   T +++ +P++ A   GH   +E+LL++G   +A+  L         + +  + 
Sbjct: 197 -TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC 255

Query: 115 NHQEVVELLIKYGADVH 131
               +V +L+KYGA ++
Sbjct: 256 EFFGIVNILLKYGAQIN 272


>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
          Length = 305

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 55/164 (33%), Positives = 83/164 (50%), Gaps = 6/164 (3%)

Query: 11  LEAARAGQDDEV-RILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           L+AA   Q+  + + L   G P   D L  + LH A   GH      LL AG + DAR  
Sbjct: 116 LKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDL 175

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
           +DRTP+  A   GH  I++ LL  GA VNA+D +  T LH A    H + +E LI+ GA 
Sbjct: 176 LDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAH 235

Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEIL-----QIAMQNQINTNP 168
           ++ Q K   TA   ++ +G+    ++L     ++ ++N  +  P
Sbjct: 236 LNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTP 279



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 40/124 (32%), Positives = 65/124 (52%)

Query: 23  RILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
           ++L+A       D L  +P+  A + GH    + LL  G   +AR K+  TPLH+A    
Sbjct: 162 KLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTR 221

Query: 83  HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
           H   +E L++ GA +NA+D    TALH A  H   + ++LL+ YGA++  ++    T   
Sbjct: 222 HPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQ 281

Query: 143 ISID 146
           ++ D
Sbjct: 282 LARD 285


>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
           a [Homo sapiens]
          Length = 518

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 53/166 (31%), Positives = 82/166 (49%), Gaps = 9/166 (5%)

Query: 38  GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
           G   LHLAA  GH+   ++LL AG   +A T  + TPL +A   G   ++ +LL+HGA+V
Sbjct: 79  GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 138

Query: 98  N-AKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
           N +  M    +LH A+   + E+++LL++ GA+   Q  F  T   ++   G     E L
Sbjct: 139 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK---LESL 195

Query: 157 QIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENS 202
            I + +  N N ++ D      ATP FI    G      L+ S  +
Sbjct: 196 SILISSGANVNCQALD-----KATPLFIAAQEGHTKCVELLLSSGA 236



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 2/122 (1%)

Query: 10  LLEAARAGQDDEVRILMANGAPF--TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
           L  A   GQ D +R+L+ +GA    +    G + LH A+   +    ++LLR G +++ +
Sbjct: 116 LFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQ 175

Query: 68  TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
                TPL +AA  G    + +L+  GA+VN + + K T L  A +  H + VELL+  G
Sbjct: 176 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 235

Query: 128 AD 129
           AD
Sbjct: 236 AD 237



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 3/128 (2%)

Query: 10  LLEAARAGQDDEVRILMANGAPFTTDWLG-TSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
           L  AA+ G+ + + IL+++GA      L   +PL +AAQ GH    E+LL +G   D   
Sbjct: 183 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYC 242

Query: 69  KVD--RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
             D  + P+H AA  GH  I+++L+          + K++ ++ A    H++ +E+L++ 
Sbjct: 243 NEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRN 302

Query: 127 GADVHTQS 134
           G     Q+
Sbjct: 303 GYSPDAQA 310



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 56/206 (27%), Positives = 90/206 (43%), Gaps = 45/206 (21%)

Query: 32  FTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTP---------------- 74
           FT  +  T S + LAA+ G+      LL+ G S D        P                
Sbjct: 3   FTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQML 62

Query: 75  --------------------LHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEH 114
                               LH+AAS+GH  IV++LL+ GAD NA  + + T L  A E+
Sbjct: 63  INADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVEN 122

Query: 115 NHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTV 174
              +V+ LL+++GA+V+     C   ++       ++ AEI+++ ++     N E  D  
Sbjct: 123 GQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKLLLRK--GANKECQDDF 178

Query: 175 TIHAATPQFIIGP-GGVVNLTGLVSS 199
            I   TP F+    G + +L+ L+SS
Sbjct: 179 GI---TPLFVAAQYGKLESLSILISS 201



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 35/137 (25%), Positives = 68/137 (49%), Gaps = 10/137 (7%)

Query: 4   VDLGKKLLEAARAGQDDEVRILMANGAP---FTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
           +D    L  AA+ G    V +L+++GA    +  +     P+H AAQ GH    ++L+  
Sbjct: 210 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL 269

Query: 61  GVSRDARTKVDR-TPLHMAASEGHASIVEVLLKHGADVNAKDML-----KMTALHWATEH 114
             +R   T +++ +P++ A   GH   +E+LL++G   +A+  L         + +  + 
Sbjct: 270 -TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC 328

Query: 115 NHQEVVELLIKYGADVH 131
               +V +L+KYGA ++
Sbjct: 329 EFFGIVNILLKYGAQIN 345


>gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
          Length = 327

 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 47/134 (35%), Positives = 73/134 (54%), Gaps = 1/134 (0%)

Query: 11  LEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
           L+AA  G+   +   +A+G    T D    + LH A+  GH    E LL  G + D + +
Sbjct: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
           +D T +H A   GH  +V++L  HGAD N +D    TALH A   N  ++++LL+ +GAD
Sbjct: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGAD 272

Query: 130 VHTQSKFCKTAFDI 143
           + T++   KT  D+
Sbjct: 273 MMTKNLAGKTPTDL 286



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 44/123 (35%), Positives = 63/123 (51%)

Query: 45  AAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLK 104
           AA  G     E  L  G S D   +  RT LH A+ EGH  I+E LL +GA V+ +D L 
Sbjct: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214

Query: 105 MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQI 164
            TA+HWA    H EVV+LL  +GAD + + K   TA   ++      + ++L +   + +
Sbjct: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274

Query: 165 NTN 167
             N
Sbjct: 275 TKN 277



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 28/88 (31%), Positives = 43/88 (48%)

Query: 70  VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
           VD      AA EG   ++E  L  G   +  D  + TALH A+   H E++E L+  GA 
Sbjct: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206

Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQ 157
           V  Q +   TA   +   G+ ++ ++LQ
Sbjct: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQ 234


>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
           repeats isoform 2 [Homo sapiens]
          Length = 1403

 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 49/133 (36%), Positives = 72/133 (54%), Gaps = 1/133 (0%)

Query: 25  LMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
           ++ +G   TT D  G + LHLAA+YGH    + LL+     +      RT LH AA    
Sbjct: 74  ILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADC 133

Query: 84  ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
            S +++L  HGA VNAKD+   T L  AT+ +   + +LLI  GADV+++ K  +TA  +
Sbjct: 134 PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALML 193

Query: 144 SIDNGNEDLAEIL 156
             + G  D  E+L
Sbjct: 194 GCEYGCRDAVEVL 206



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 43/140 (30%), Positives = 69/140 (49%)

Query: 23  RILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
           ++L  N      D  G + LH AA     S+ ++L   G S +A+    RTPL +A    
Sbjct: 106 KLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMS 165

Query: 83  HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
             +I ++L+  GADVN++D    TAL    E+  ++ VE+LIK GAD+         +  
Sbjct: 166 RPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSY 225

Query: 143 ISIDNGNEDLAEILQIAMQN 162
            +    N D+  +L+ A +N
Sbjct: 226 YARIGDNLDILTLLKTASEN 245


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.126    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,311,880
Number of Sequences: 37866
Number of extensions: 569245
Number of successful extensions: 7229
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 422
Number of HSP's successfully gapped in prelim test: 249
Number of HSP's that attempted gapping in prelim test: 3514
Number of HSP's gapped (non-prelim): 2769
length of query: 395
length of database: 18,247,518
effective HSP length: 104
effective length of query: 291
effective length of database: 14,309,454
effective search space: 4164051114
effective search space used: 4164051114
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.