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Search of human proteins with 7706093
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7706093 toll-like receptor 7 [Homo sapiens]
(1049 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7706093 toll-like receptor 7 [Homo sapiens] 2120 0.0
gi|20302168 toll-like receptor 8 [Homo sapiens] 807 0.0
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 568 e-162
gi|4507531 toll-like receptor 3 [Homo sapiens] 196 1e-49
gi|16751843 toll-like receptor 5 [Homo sapiens] 192 2e-48
gi|19718734 toll-like receptor 2 [Homo sapiens] 169 2e-41
gi|19924149 toll-like receptor 4 precursor [Homo sapiens] 148 3e-35
gi|62865621 toll-like receptor 10 precursor [Homo sapiens] 133 8e-31
gi|62865618 toll-like receptor 10 precursor [Homo sapiens] 133 8e-31
gi|41350337 toll-like receptor 1 [Homo sapiens] 131 4e-30
gi|20143971 toll-like receptor 6 [Homo sapiens] 130 6e-30
gi|188528675 slit homolog 1 [Homo sapiens] 124 6e-28
gi|11321571 slit homolog 3 [Homo sapiens] 123 8e-28
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 115 3e-25
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 114 5e-25
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 107 4e-23
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 106 1e-22
gi|19743846 decorin isoform a preproprotein [Homo sapiens] 104 5e-22
gi|4503271 decorin isoform a preproprotein [Homo sapiens] 104 5e-22
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 103 8e-22
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 103 1e-21
gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens] 102 2e-21
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 100 7e-21
gi|4759146 slit homolog 2 [Homo sapiens] 99 2e-20
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 99 2e-20
gi|225579152 insulin-like growth factor binding protein, acid la... 98 5e-20
gi|4826772 insulin-like growth factor binding protein, acid labi... 98 5e-20
gi|41350214 asporin [Homo sapiens] 97 6e-20
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 97 8e-20
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 96 2e-19
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 2120 bits (5494), Expect = 0.0
Identities = 1049/1049 (100%), Positives = 1049/1049 (100%)
Query: 1 MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP 60
MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
Sbjct: 1 MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP 60
Query: 61 GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP 120
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
Sbjct: 61 GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP 120
Query: 121 RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG 180
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
Sbjct: 121 RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG 180
Query: 181 QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI 240
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
Sbjct: 181 QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI 240
Query: 241 QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN 300
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
Sbjct: 241 QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN 300
Query: 301 SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM 360
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
Sbjct: 301 SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM 360
Query: 361 NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF 420
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
Sbjct: 361 NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF 420
Query: 421 KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK 480
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
Sbjct: 421 KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK 480
Query: 481 EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP 540
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
Sbjct: 481 EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP 540
Query: 541 LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK 600
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
Sbjct: 541 LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK 600
Query: 601 LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN 660
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
Sbjct: 601 LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN 660
Query: 661 SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN 720
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
Sbjct: 661 SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN 720
Query: 721 CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL 780
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
Sbjct: 721 CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL 780
Query: 781 HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL 840
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
Sbjct: 781 HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL 840
Query: 841 ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK 900
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
Sbjct: 841 ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK 900
Query: 901 DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK 960
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
Sbjct: 901 DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK 960
Query: 961 YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ 1020
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
Sbjct: 961 YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ 1020
Query: 1021 AHPYFWQCLKNALATDNHVAYSQVFKETV 1049
AHPYFWQCLKNALATDNHVAYSQVFKETV
Sbjct: 1021 AHPYFWQCLKNALATDNHVAYSQVFKETV 1049
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 807 bits (2085), Expect = 0.0
Identities = 439/1023 (42%), Positives = 625/1023 (61%), Gaps = 17/1023 (1%)
Query: 30 FPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLD 89
F ++ PCD + VI +C+++ L E+P + T L L+ N I I+ SF L
Sbjct: 30 FSRSYPCDEKKQ--NDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQ 87
Query: 90 HLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPS 149
+L +I+ N + L I +F L L+ L L+ NQL +IP GLP S
Sbjct: 88 NLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPES 147
Query: 150 LQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVL 209
L LSL NNI++I KE ++ L N++ LYL NCY+ C + +IE F LT L++L
Sbjct: 148 LTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKT-NIEDGVFETLTNLELL 206
Query: 210 SLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFP 269
SL N+++ VP LPS+L +L+L N I I E+DF L L +LDLSGNCPRC+NAPFP
Sbjct: 207 SLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFP 266
Query: 270 CAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKE 329
C PC + + I AF LT+L+ L L S SL+ + WFKN+ L+ LDL N+L E
Sbjct: 267 CVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGE 326
Query: 330 IGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFN 389
I FL LP L LDLSFN+ Y +N+S+ FS L SL+ L +RGYVF+EL+ +
Sbjct: 327 IASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDD 386
Query: 390 LSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNAR 449
PL L NL ++LG NFIK + +F+ F L++I LS N+ISP + + +++
Sbjct: 387 FQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSS- 445
Query: 450 TSVESYEPQVLEQLHY-FRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFV 508
S++ + ++ F +D ++ F + C YG+ LDLS NSIFF+
Sbjct: 446 ----SFQRHIRKRRSTDFEFDPHSNFYHFTRP-----LIKPQCAAYGKALDLSLNSIFFI 496
Query: 509 KSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKL 568
+ F++L + CLNLS N +Q L+G+EF + ++YLD +NNRLD +++A EL L
Sbjct: 497 GPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDL 556
Query: 569 EVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSR-TMESESLRTLEFR 627
EVLD+S NSHYF+ G+TH L F +N L+ L ++ N+I + T + +ES+SL L F
Sbjct: 557 EVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFS 616
Query: 628 GNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGL 687
GN LD+LW + DNRY+ +FK L L LD+S N L +P+ F +P +L L + N L
Sbjct: 617 GNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNML 676
Query: 688 KSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAF 747
K F+W LQ LE LDL N+L + + LS+ + SL+ L+L +N+I L FL +
Sbjct: 677 KFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVS 736
Query: 748 QLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVN-HTEVTIP 806
L++LDLSSN ++ I K++ L ML LH N F CTCD F W++ H V IP
Sbjct: 737 SLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIP 796
Query: 807 YLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWD 866
L DV C PG +G+S++SL+L TC D+T +ILF + ++ +M+ A HL++WD
Sbjct: 797 RLV-DVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWD 855
Query: 867 VWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNL 926
VW+IY+ C AK+KGY+ L + YDA+I YDTKD +VT+WV+ EL LE+ R+K+ L
Sbjct: 856 VWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLL 915
Query: 927 CLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVI 986
CLEERDW PG +++NL QSI SKKTVFV+T KYAK+ NFK AFYL+ QRLMDE +DVI
Sbjct: 916 CLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVI 975
Query: 987 ILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFK 1046
I I LE Q S++L+LR+R+C SS+L+WP NP+A FWQ L+N + T+N Y+ ++
Sbjct: 976 IFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYV 1035
Query: 1047 ETV 1049
+++
Sbjct: 1036 DSI 1038
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 568 bits (1464), Expect = e-162
Identities = 372/1041 (35%), Positives = 551/1041 (52%), Gaps = 37/1041 (3%)
Query: 14 ILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP----GGIPTNTTN 69
+L I+++ L P LPC++ + H +V+C L +P N T+
Sbjct: 13 LLVQAIMLAMTLALGTLPAFLPCEL-----QPHGLVNCNWLFLKSVPHFSMAAPRGNVTS 67
Query: 70 LTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYL 129
L+L+ N I + + F L L ++ + NC P+ L + C + I+P +F + L
Sbjct: 68 LSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPC--HMTIEPSTFLAVPTL 125
Query: 130 KSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPC 189
+ L L N ++ +P LP SL LSL NI + +L L + L++ NCYY+NPC
Sbjct: 126 EELNLSYNNIMTVP-ALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPC 184
Query: 190 YVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLN 249
+ + A L L L LSLK NN+T VP LPS+L L L N I K+ +D NL
Sbjct: 185 RQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLT 244
Query: 250 QLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRW 309
L++LD+ GNC RC +AP PC C + P Q+ + F L+ L+ L L +SL + W
Sbjct: 245 ALRVLDVGGNCRRCDHAPNPCMECPRHFP-QLHPDTFSHLSRLEGLVLKDSSLSWLNASW 303
Query: 310 FKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSL 369
F+ + L+ LDLS+NFL K I K L L +L+LSFN++ +V A ++L+ +F SL
Sbjct: 304 FRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSL 363
Query: 370 KSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLS 429
+LK L + G F+ L L PL L L+ L L NFI A L +F+ F L+ +DLS
Sbjct: 364 VALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLS 423
Query: 430 VNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNE 489
N+IS + + + E E++ D + E
Sbjct: 424 DNRISGASE-----------LTATMGEADGGEKVWLQPGDLAPAPVDTPSSE----DFRP 468
Query: 490 SCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDF 549
+C TLDLS+N++ V+ F LS L+CL LS N ISQ +NGS+F PL L+ LD
Sbjct: 469 NCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDL 528
Query: 550 SNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDIS 609
S+N+LDL H +F EL +LE LD+S NS F +G+ H +F +L+ L+ L + N+I
Sbjct: 529 SHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIH 588
Query: 610 SSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGV 669
S S+ + S SLR L+F GN L +W EGD YL F+ L L LD+S+N L L
Sbjct: 589 SQVSQQLCSTSLRALDFSGNALGHMWAEGD-LYLHFFQGLSGLIWLDLSQNRLHTLLPQT 647
Query: 670 FDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLI 729
+P +L+ L L N L F W L L LE LDL+ NQL + L+ L
Sbjct: 648 LRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLD 707
Query: 730 LKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTC 789
+ N I + F A +LR L+LS+N ++ + + F + + L++L + N C C
Sbjct: 708 VSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGP-LASALQILDVSANPLHCAC 766
Query: 790 DAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLS-IS 848
A F+ ++ + +P L + V C PG +G S+ + DL C + + F+LS ++
Sbjct: 767 GAA-FMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLA 825
Query: 849 VSLFLMVMMTASHLYFWDVWYIYHFCKAKI--KGYQRLISPDCC-YDAFIVYDTKDPAVT 905
V+L L V M HL WD+WY +H C A + +G Q D YDAF+V+D AV
Sbjct: 826 VALGLGVPM-LHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVA 884
Query: 906 EWVLAELVAKLEDPREK-HFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKT 964
+WV EL +LE+ R + LCLEERDWLPG+ + ENL S+ S+KT+FV+ +
Sbjct: 885 DWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVS 944
Query: 965 ENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPY 1024
+ +F L+ QRL++++ DV++L+ L ++S++++LR+RLC SVL WP P
Sbjct: 945 GLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRS 1004
Query: 1025 FWQCLKNALATDNHVAYSQVF 1045
FW L AL DNH Y++ F
Sbjct: 1005 FWAQLGMALTRDNHHFYNRNF 1025
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 196 bits (497), Expect = 1e-49
Identities = 230/901 (25%), Positives = 390/901 (43%), Gaps = 116/901 (12%)
Query: 216 VTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNC------PRCYNAP-F 268
+T VP LP+ +T L L +N + ++ +F +QL LD+ N C P
Sbjct: 42 LTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPML 101
Query: 269 PCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAK 328
++N Q+ F T L L L SNS+Q + F L LDLS N L+
Sbjct: 102 KVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSS 161
Query: 329 -EIGDAKFLHFLPSLI------------QLDLSFNFELQVYRASMNLSQAFSSLKSLKIL 375
++G L L L+ +LD+ N L+ S N + FS I
Sbjct: 162 TKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIG 221
Query: 376 RIRGYVFKELK---SFNLSPLHNLQNLEVLDLGTNFIKIANLS----MFKQFKRLKVIDL 428
R+ G ++ S L N + +L + +++ S + ++ L ++DL
Sbjct: 222 RLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDL 281
Query: 429 SVNKISPSGDSS-----EVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKN-KEA 482
S N ++ G+ S ++ + +++ L L RY RS ++ A
Sbjct: 282 SYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLA 341
Query: 483 SFMSVNESCYKYGQTLD---LSKNSIFFVKSSDFQHLSFLKCLNLSGNLIS-QTLNGSEF 538
S +++ +++ + L+ + N I +KS+ F L LK L+LS + S +TL F
Sbjct: 342 SLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETF 401
Query: 539 QPLAE--LRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN--------SHYFQSEGITHM 588
LA L L+ + N++ + S AF L LEVLD+ N + E I +
Sbjct: 402 VSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEI 461
Query: 589 -LNFTKNLKV----------LQKLMMND---NDISSSTSRTMESESLRTLEFRGNHLDVL 634
L++ K L++ LQ+LM+ ++ SS S +L L+ N++
Sbjct: 462 YLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNI--- 518
Query: 635 WREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMP-------PNLKNLSLAKNGL 687
N + + L KLE LD+ N+L+ L G P +L L+L NG
Sbjct: 519 ----ANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGF 574
Query: 688 KSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAF 747
+ + L L+ +DL N L T+P + N SLK+L L+ N I S+ K AF
Sbjct: 575 DEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAF 634
Query: 748 QLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAV-WFVWWVNHTEVTIP 806
+ NL L + N F CTC+++ WFV W+N T IP
Sbjct: 635 R-------------------------NLTELDMRFNPFDCTCESIAWFVNWINETHTNIP 669
Query: 807 YLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWD 866
L++ C P + G V D +C+ + F ++ S+ L + ++ H W
Sbjct: 670 ELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWR 729
Query: 867 VWYIYHFCKAKIKGYQRL--ISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHF 924
+ + ++ ++ G++ + + Y A+I++ KD +WV + + ++
Sbjct: 730 ISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKD---KDWVWEHFSSM--EKEDQSL 784
Query: 925 NLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAK---TENFKIAFYLSHQRLMDE 981
CLEERD+ G LE + SI+ S+K +FV+T K + FK+ + + Q+ +++
Sbjct: 785 KFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKV--HHAVQQAIEQ 842
Query: 982 KVDVIILIFLEK--PFQKSKFLQLRKRLCGS-SVLEWPTNPQAHPYFWQCLKNALATDNH 1038
+D IIL+FLE+ ++ + L LR+ + S +L WP + F L+ AL + N
Sbjct: 843 NLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKNS 902
Query: 1039 V 1039
V
Sbjct: 903 V 903
Score = 116 bits (291), Expect = 1e-25
Identities = 171/721 (23%), Positives = 282/721 (39%), Gaps = 142/721 (19%)
Query: 45 NHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCN----- 99
+H + DC+ LT++P +PTN T L LT N + + A+F R L +D N
Sbjct: 31 SHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKL 90
Query: 100 ----CVPIPLGSKNNMCIKRL-QIKPRSFSGLTYLKSLYLDGNQLLEI---PQGLPPSLQ 151
C +P+ N+ L Q+ ++F+ T L L+L N + +I P +L
Sbjct: 91 EPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLI 150
Query: 152 LLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSL 211
L L N + S + +L N++ L L N S E D F N + LK L L
Sbjct: 151 TLDLSHNGLSSTKLGTQVQLENLQELLLS-----NNKIQALKSEELDIFAN-SSLKKLEL 204
Query: 212 KDNNVT--------AVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGN-CPR 262
N + A+ + L + L ++ K+ + N ++ L LS +
Sbjct: 205 SSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELAN--TSIRNLSLSNSQLST 262
Query: 263 CYNAPFPCAPCKNNSPLQIPVN--------AFDALTELKVLRLHSNSLQHVPPRWFKNIN 314
N F N + L + N +F L +L+ L N++QH+ +
Sbjct: 263 TSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLF 322
Query: 315 KLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNL---------SQA 365
++ L+L ++F + I L SL ++D F+F+ +N+ S
Sbjct: 323 NVRYLNLKRSFTKQSIS-------LASLPKID-DFSFQWLKCLEHLNMEDNDIPGIKSNM 374
Query: 366 FSSLKSLKILRIRGYVFKELKSFNLSPLHNLQN--LEVLDLGTNFIKIANLSMFKQFKRL 423
F+ L +LK L + F L++ +L + L +L+L N I F L
Sbjct: 375 FTGLINLKYLSLSN-SFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHL 433
Query: 424 KVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLH--YFRYDKYARSCRFKNKE 481
+V+DL +N+I + E + LE + Y Y+KY
Sbjct: 434 EVLDLGLNEIG---------------QELTGQEWRGLENIFEIYLSYNKY---------- 468
Query: 482 ASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPL 541
L L++NS V S L + N+ + S FQPL
Sbjct: 469 ----------------LQLTRNSFALVPSLQRLMLRRVALKNVDS-------SPSPFQPL 505
Query: 542 AELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN--SHYFQSEGITHMLNFTKNLKVLQ 599
L LD SNN + ++ E L KLE+LD+ N + ++ + F K L L
Sbjct: 506 RNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLH 565
Query: 600 KLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISK 659
L + N D +++FK+L +L+ +D+
Sbjct: 566 ILNLESNGF------------------------------DEIPVEVFKDLFELKIIDLGL 595
Query: 660 NSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKL-QCLKNLETLDLSHNQLTTVPERL 718
N+L+ LP+ VF+ +LK+L+L KN + S K +NL LD+ N E +
Sbjct: 596 NNLNTLPASVFNNQ-VSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESI 654
Query: 719 S 719
+
Sbjct: 655 A 655
Score = 43.5 bits (101), Expect = 0.001
Identities = 38/131 (29%), Positives = 56/131 (42%), Gaps = 6/131 (4%)
Query: 653 EELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLT 712
E D S L+ +P D +P N+ L+L N L+ L +LD+ N ++
Sbjct: 33 EVADCSHLKLTQVP----DDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTIS 88
Query: 713 TVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVL 772
+ L LK L L++N++ L+ L L L SN IQ I+ F +
Sbjct: 89 KLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQ-- 146
Query: 773 NNLKMLLLHHN 783
NL L L HN
Sbjct: 147 KNLITLDLSHN 157
Score = 38.9 bits (89), Expect = 0.026
Identities = 45/147 (30%), Positives = 65/147 (44%), Gaps = 11/147 (7%)
Query: 696 QCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLS 755
+C + E D SH +LT VP+ L ++ L L +NQ+R L QL LD+
Sbjct: 27 KCTVSHEVADCSHLKLTQVPDDLPT---NITVLNLTHNQLRRLPAANFTRYSQLTSLDVG 83
Query: 756 SNKIQMIQKTSFPE--NVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVT 813
N I ++ PE L LK+L L HN D F + N TE+ + +
Sbjct: 84 FNTISKLE----PELCQKLPMLKVLNLQHNELSQLSDKT-FAFCTNLTELHLMSNSIQKI 138
Query: 814 CVGPGAHKGQSVISLDLYTCELDLTNL 840
P K +++I+LDL L T L
Sbjct: 139 KNNPFV-KQKNLITLDLSHNGLSSTKL 164
>gi|16751843 toll-like receptor 5 [Homo sapiens]
Length = 858
Score = 192 bits (487), Expect = 2e-48
Identities = 214/859 (24%), Positives = 367/859 (42%), Gaps = 115/859 (13%)
Query: 215 NVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCK 274
N+T VP VL +T L L N I + F L QLQ+L+L
Sbjct: 37 NLTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQY-------------- 81
Query: 275 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAK 334
+PL I AF L L++L L S+ + + P F+ + L EL L L+ +
Sbjct: 82 --TPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDG 139
Query: 335 FLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLH 394
+ L +L +LDLS N +Y L +F L SLK + + L PL
Sbjct: 140 YFRNLKALTRLDLSKNQIRSLY-----LHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQ 194
Query: 395 NLQNLEVLDLGTNFI-KIANLSMFKQFKRLKVIDLSVNKISPSGDSSEV-GFCSNARTSV 452
+ L L N + ++ K + + L + +S +G + ++ G SNA +
Sbjct: 195 G-KTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKS 253
Query: 453 ESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSD 512
+++ L H+ + + +F + S ++ LDLS +F + S
Sbjct: 254 QAFS---LILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRH---LDLSHGFVFSLNSRV 307
Query: 513 FQHLSFLKCLNLSGNLIS-------------QTLN----------GSEFQPLAELRYLDF 549
F+ L LK LNL+ N I+ Q LN S F L ++ Y+D
Sbjct: 308 FETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDL 367
Query: 550 SNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDIS 609
N + ++ F+ L KL+ LD+ N+ L + + + ++ N +
Sbjct: 368 QKNHIAIIQDQTFKFLEKLQTLDLRDNA-----------LTTIHFIPSIPDIFLSGNKLV 416
Query: 610 SSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGV 669
+ + + + E R +LD+L+ + L+ L +++N S
Sbjct: 417 TLPKINLTANLIHLSENRLENLDILY---------FLLRVPHLQILILNQNRFSSCSGDQ 467
Query: 670 FDGMPPNLKNLSLAKNGLK-----SFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRS 724
P+L+ L L +N L+ W + L +L+ L L+HN L ++P + + +
Sbjct: 468 TPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527
Query: 725 LKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNR 784
L+ L L +N++ L+ L L LD+S N++ +V +L +L + HN+
Sbjct: 528 LRGLSLNSNRLTVLSHNDLPA--NLEILDISRNQLLAPNP-----DVFVSLSVLDITHNK 580
Query: 785 FLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTC-ELDLTNLILF 843
F+C C+ F+ W+NHT VTI D+ CV P + G S+ SL C E ++ + F
Sbjct: 581 FICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKF 640
Query: 844 SL----SISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLI--------SPDCC- 890
SL +++++LFLM ++T V FC K QRL+ PD
Sbjct: 641 SLFIVCTVTLTLFLMTILT--------VTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYK 692
Query: 891 YDAFIVYDTKDPAVTEWVLAELVAKLED--PREKHFNLCLEERDWLPGQPVLENLSQSIQ 948
YDA++ + +KD WV L+ L+ + FNLC EERD++PG+ + N+ +I
Sbjct: 693 YDAYLCFSSKD---FTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIW 749
Query: 949 LSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLE--KPFQKSKFLQLRKR 1006
S+K V +++ + + AF + R + + +I++ + +Q K +R
Sbjct: 750 NSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGF 809
Query: 1007 LCGSSVLEWPTNPQAHPYF 1025
+ L WP + Q +F
Sbjct: 810 VQKQQYLRWPEDLQDVGWF 828
Score = 53.1 bits (126), Expect = 1e-06
Identities = 78/335 (23%), Positives = 128/335 (38%), Gaps = 42/335 (12%)
Query: 474 SCRFKNKEASFMSVN----ESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLI 529
SC F + A + N + L LS N I V +S F L L+ L L
Sbjct: 23 SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT 82
Query: 530 SQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVL--------DISSNSHYFQ 581
T++ F+ L LR LD ++++ LH AF+ L L L D YF+
Sbjct: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR 142
Query: 582 SEGITHMLNFTKN-------------LKVLQKLMMNDNDISSSTSRTMESESLRTLEFRG 628
+ L+ +KN L L+ + + N I +E +TL F
Sbjct: 143 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS 202
Query: 629 NHLDVLWREGD---NRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAK- 684
+ L+ + + F+N++ LE LD+S N + +G F + SL
Sbjct: 203 LAANSLYSRVSVDWGKCMNPFRNMV-LEILDVSGNGWTVDITGNFSNAISKSQAFSLILA 261
Query: 685 ----------NGLKSFSWKKLQCL--KNLETLDLSHNQLTTVPERLSNCSRSLKNLILKN 732
+ +K L ++ LDLSH + ++ R+ + LK L L
Sbjct: 262 HHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAY 321
Query: 733 NQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSF 767
N+I + L+ L+LS N + + ++F
Sbjct: 322 NKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNF 356
Score = 49.7 bits (117), Expect = 1e-05
Identities = 78/307 (25%), Positives = 121/307 (39%), Gaps = 38/307 (12%)
Query: 149 SLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKV 208
S++ L L +FS+ L ++++L L N + Y ++ LNL+ +
Sbjct: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
Query: 209 LSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPF 268
L +N +P V + L N IA IQ+ F L +LQ LDL N +
Sbjct: 349 GELYSSNFYGLPKV-----AYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHF-I 402
Query: 269 PCAP---CKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFK-NINKLQELDLSQN 324
P P N + +P A ++ L N L+++ +F + LQ L L+QN
Sbjct: 403 PSIPDIFLSGNKLVTLPKINLTA----NLIHLSENRLENLDILYFLLRVPHLQILILNQN 458
Query: 325 FLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKE 384
+ GD PSL QL L N LQ+ + F L L++L +
Sbjct: 459 RFSSCSGDQTPSEN-PSLEQLFLGENM-LQLAWETELCWDVFEGLSHLQVLYLNHNYLNS 516
Query: 385 LKSFNLSPLHNLQ-------------------NLEVLDLGTNFIKIANLSMFKQFKRLKV 425
L S L L+ NLE+LD+ N + N +F L V
Sbjct: 517 LPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVS---LSV 573
Query: 426 IDLSVNK 432
+D++ NK
Sbjct: 574 LDITHNK 580
Score = 40.0 bits (92), Expect = 0.012
Identities = 57/212 (26%), Positives = 92/212 (43%), Gaps = 25/212 (11%)
Query: 62 GIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVP----IPLGSKNNMCIKRLQ 117
G+P + L NHI I +F L+ L +D R N + IP + +L
Sbjct: 358 GLP-KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLV 416
Query: 118 IKPR--SFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENL-TELANI 174
P+ + L +L L+ +L + P LQ+L L N S + +E ++
Sbjct: 417 TLPKINLTANLIHLSENRLENLDILYFLLRV-PHLQILILNQNRFSSCSGDQTPSENPSL 475
Query: 175 EILYLGQN----CYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTE- 229
E L+LG+N + C+ D F L+ L+VL L N + ++P + S LT
Sbjct: 476 EQLFLGENMLQLAWETELCW-------DVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTAL 528
Query: 230 --LYLYNNMIAKIQEDDFNNLNQLQILDLSGN 259
L L +N + + +D L+ILD+S N
Sbjct: 529 RGLSLNSNRLTVLSHNDLP--ANLEILDISRN 558
>gi|19718734 toll-like receptor 2 [Homo sapiens]
Length = 784
Score = 169 bits (427), Expect = 2e-41
Identities = 216/785 (27%), Positives = 341/785 (43%), Gaps = 92/785 (11%)
Query: 289 LTE-LKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDL 347
LTE +K L L +N + ++ + LQ L L+ N + D+ L SL LDL
Sbjct: 50 LTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDS--FSSLGSLEHLDL 107
Query: 348 SFNFELQVYRASMNLSQA-FSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGT 406
S+N+ NLS + F L SL L + G +K L +L +L L++L +G
Sbjct: 108 SYNY-------LSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSL--FSHLTKLQILRVG- 157
Query: 407 NFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQ---- 462
N+ F + +R L+ + S + + S+++ +L
Sbjct: 158 ------NMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHI 211
Query: 463 --LHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFF-VKSSDFQHLSFL 519
L F + C + ++ + + S G+T L K F VK +D +
Sbjct: 212 LLLEIFVDVTSSVEC-LELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVM 270
Query: 520 KCLNLSGNLISQ-----TLNG-SEFQPLAELRYLD------FSNNRLDLLHSTAFEELHK 567
K LN L+ TLNG F+ R +D + RL + F +L
Sbjct: 271 KLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLST 330
Query: 568 LEVLD------ISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESE-- 619
L L NS F + +++LK L+ L +++N + + E
Sbjct: 331 LYSLTERVKRITVENSKVFLVPCL-----LSQHLKSLEYLDLSENLMVEEYLKNSACEDA 385
Query: 620 --SLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNL 677
SL+TL R NHL L + G+ L KNL + DISKNS +P P +
Sbjct: 386 WPSLQTLILRQNHLASLEKTGET--LLTLKNLTNI---DISKNSFHSMPETC--QWPEKM 438
Query: 678 KNLSLAKNGLKSFSWKKLQCL-KNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIR 736
K L+L+ + S + C+ K LE LD+S+N L L LK L + N++
Sbjct: 439 KYLNLSSTRIHSVTG----CIPKTLEILDVSNNNLNLFSLNLPQ----LKELYISRNKLM 490
Query: 737 SLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVW 796
+L L L L +S N I K + LK L N F+C+C+ + F
Sbjct: 491 TLPDASLLP--MLLVLKISRNAITTFSKEQLDS--FHTLKTLEAGGNNFICSCEFLSFTQ 546
Query: 797 WVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVM 856
+ + C P +GQ V + L E T L+ + +LFL+++
Sbjct: 547 EQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVS---GMCCALFLLIL 603
Query: 857 MTASHLY-FWDVWYI---YHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAEL 912
+T + F +WY+ + + +AK K ++ S + CYDAF+ Y +D WV +
Sbjct: 604 LTGVLCHRFHGLWYMKMMWAWLQAKRKP-RKAPSRNICYDAFVSYSERD---AYWVENLM 659
Query: 913 VAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFY 972
V +LE+ F LCL +RD++PG+ +++N+ SI+ S KTVFV+++ + K+E K
Sbjct: 660 VQELENFNPP-FKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELD 718
Query: 973 LSHQRLMDEKVDVIILIFLEKPFQK----SKFLQLRKRLCGSSVLEWPTNPQAHPYFWQC 1028
SH RL DE D ILI LE P +K +F +LRK + + LEWP + FW
Sbjct: 719 FSHFRLFDENNDAAILILLE-PIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN 777
Query: 1029 LKNAL 1033
L+ A+
Sbjct: 778 LRAAI 782
Score = 72.8 bits (177), Expect = 2e-12
Identities = 129/540 (23%), Positives = 228/540 (42%), Gaps = 76/540 (14%)
Query: 206 LKVLSLKDNNVTAVPTVLPS---TLTELYLYNNMIAKIQEDDFNNLNQLQILDLS----G 258
+K L L +N +T + L L L +N I I+ED F++L L+ LDLS
Sbjct: 54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLS 113
Query: 259 NCPRCYNAPFPCAPCKN--NSPLQI--PVNAFDALTELKVLRL-HSNSLQHVPPRWFKNI 313
N + P N +P + + F LT+L++LR+ + ++ + + F +
Sbjct: 114 NLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGL 173
Query: 314 NKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLK 373
L+EL++ + L + + K L + ++ L L + + ++++ S++
Sbjct: 174 TFLEELEIDASDL--QSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVT------SSVE 225
Query: 374 ILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGT-NFIKIANLSMFKQFKRLK----VIDL 428
L +R +L +F+ S L + ++ T +KI + S+F+ K L +++L
Sbjct: 226 CLELRD---TDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLEL 282
Query: 429 SVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLH----YFRYDKYARSCRFKNKEASF 484
+ + +G + ++ E + +LH Y YD
Sbjct: 283 EFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYD--------------- 327
Query: 485 MSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNL-ISQTLNGSEFQPL-A 542
+S S + + + + + +F V QHL L+ L+LS NL + + L S +
Sbjct: 328 LSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWP 387
Query: 543 ELRYLDFSNNRLDLLHST--AFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK 600
L+ L N L L T L L +DIS NS + E + + +K L
Sbjct: 388 SLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPE----TCQWPEKMKYL-- 441
Query: 601 LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFK-NLLKLEELDISK 659
++SS+ ++ +TLE LDV N L LF NL +L+EL IS+
Sbjct: 442 ------NLSSTRIHSVTGCIPKTLEI----LDV-----SNNNLNLFSLNLPQLKELYISR 486
Query: 660 NSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLS 719
N L LP + P L L +++N + +FS ++L L+TL+ N E LS
Sbjct: 487 NKLMTLPDA---SLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLS 543
Score = 56.2 bits (134), Expect = 2e-07
Identities = 87/363 (23%), Positives = 144/363 (39%), Gaps = 59/363 (16%)
Query: 478 KNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSE 537
K S S+ + ++LDLS N I ++ +SD Q L+ L L+ N I+ T+
Sbjct: 37 KGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGIN-TIEEDS 95
Query: 538 FQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN-----------SHY--FQSEG 584
F L L +LD S N L L S+ F+ L L L++ N SH Q
Sbjct: 96 FSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILR 155
Query: 585 ITHMLNFTK-------NLKVLQKLMMNDNDISSSTSRTMES------------------- 618
+ +M FTK L L++L ++ +D+ S ++++S
Sbjct: 156 VGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLE 215
Query: 619 ------ESLRTLEFRGNHLDVL----WREGDNRYL---QLFKNLLKLEE--LDISK--NS 661
S+ LE R LD G+ L F+N+ +E + K N
Sbjct: 216 IFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQ 275
Query: 662 LSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNC 721
+S L FD N A + + K++ L + L + L L +
Sbjct: 276 ISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETL-TIRRLHIPRFYLFYDLSTLYSL 334
Query: 722 SRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSN-KIQMIQKTSFPENVLNNLKMLLL 780
+ +K + ++N+++ + Q L YLDLS N ++ K S E+ +L+ L+L
Sbjct: 335 TERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLIL 394
Query: 781 HHN 783
N
Sbjct: 395 RQN 397
Score = 39.7 bits (91), Expect = 0.015
Identities = 42/143 (29%), Positives = 66/143 (46%), Gaps = 24/143 (16%)
Query: 128 YLKSL-YLDGNQLLEIPQGLP--------PSLQLLSLEANNIFSIRK--ENLTELANIEI 176
+LKSL YLD ++ L + + L PSLQ L L N++ S+ K E L L N+
Sbjct: 358 HLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTN 417
Query: 177 LYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNM 236
+ + +N ++ P + K+K L+L + +V +P TL L + NN
Sbjct: 418 IDISKNSFHSMPETCQWP---------EKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNN 468
Query: 237 IAKIQEDDFNNLNQLQILDLSGN 259
+ NL QL+ L +S N
Sbjct: 469 LNLFS----LNLPQLKELYISRN 487
Score = 39.3 bits (90), Expect = 0.020
Identities = 42/154 (27%), Positives = 63/154 (40%), Gaps = 27/154 (17%)
Query: 65 TNTTNLTLTINHIPDISPASFHRLDHLVE--------------IDFRCNCVPIPLG---- 106
T T LTL DIS SFH + + I C+P L
Sbjct: 405 TGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDV 464
Query: 107 SKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQ-GLPPSLQLLSLEANNIFSIRK 165
S NN+ + L L LK LY+ N+L+ +P L P L +L + N I + K
Sbjct: 465 SNNNLNLFSLN--------LPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSK 516
Query: 166 ENLTELANIEILYLGQNCYYRNPCYVSYSIEKDA 199
E L ++ L G N + + ++S++ E+ A
Sbjct: 517 EQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQA 550
Score = 38.9 bits (89), Expect = 0.026
Identities = 29/88 (32%), Positives = 48/88 (54%), Gaps = 6/88 (6%)
Query: 707 SHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTS 766
S L ++P S + ++K+L L NN+I ++ LQ L+ L L+SN I I++ S
Sbjct: 39 SSGSLNSIP---SGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDS 95
Query: 767 FPENVLNNLKMLLLHHNRFLCTCDAVWF 794
F + L +L+ L L +N +L + WF
Sbjct: 96 F--SSLGSLEHLDLSYN-YLSNLSSSWF 120
Score = 35.4 bits (80), Expect = 0.28
Identities = 29/109 (26%), Positives = 54/109 (49%), Gaps = 6/109 (5%)
Query: 676 NLKNLSLAKNGLKSFSWKKLQCLKN-----LETLDLSHNQLTTVPERLSNCSRSLKNLIL 730
N +LS +NG+ S L + + +++LDLS+N++T + +L+ L+L
Sbjct: 24 NQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVL 83
Query: 731 KNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSF-PENVLNNLKML 778
+N I ++ + L +LDLS N + + + F P + L L +L
Sbjct: 84 TSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLL 132
>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
Length = 839
Score = 148 bits (373), Expect = 3e-35
Identities = 204/841 (24%), Positives = 365/841 (43%), Gaps = 91/841 (10%)
Query: 215 NVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCK 274
N +P LP + L L N + + F + +LQ+LDLS RC
Sbjct: 44 NFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLS----RC----------- 88
Query: 275 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAK 334
I A+ +L+ L L L N +Q + F ++ LQ+L + LA + +
Sbjct: 89 --EIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLAS-LENFP 145
Query: 335 FLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLH 394
H L +L +L+++ N S L + FS+L +L+ L + + + +L LH
Sbjct: 146 IGH-LKTLKELNVAHNLI-----QSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLH 199
Query: 395 NLQNLEV-LDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEV-GFCSNARTSV 452
+ L + LDL N + FK+ + K+ + + DS V C +
Sbjct: 200 QMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLT------LRNNFDSLNVMKTCIQGLAGL 253
Query: 453 ESYEPQVLEQLHYFRYDKYARS-----CRFKNKEASFMSVNESCYKYGQTLDLSKNSIFF 507
E + + E + +K+ +S C +E ++ Y +DL N +
Sbjct: 254 EVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLD---YYLDDIIDLF-NCLTN 309
Query: 508 VKSSDFQHLSFLKCLNLSGN-------LISQTLNGSEFQPLAELRYLDFSNNRLDLLHST 560
V S ++ + + S N L++ L L+ L F++N+
Sbjct: 310 VSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNK----GGN 365
Query: 561 AFEE--LHKLEVLDISSNSHYFQSEGITHMLNF-TKNLKVLQKLMMNDNDISSSTSRTME 617
AF E L LE LD+S N F+ G +F T +LK L ++ N + + +S +
Sbjct: 366 AFSEVDLPSLEFLDLSRNGLSFK--GCCSQSDFGTTSLKYLD---LSFNGVITMSSNFLG 420
Query: 618 SESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNL 677
E L L+F+ ++L + +F +L L LDIS +G+F+G+ +L
Sbjct: 421 LEQLEHLDFQHSNLKQMSE------FSVFLSLRNLIYLDISHTHTRVAFNGIFNGLS-SL 473
Query: 678 KNLSLAKNGLK-SFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIR 736
+ L +A N + +F L+NL LDLS QL + N SL+ L + +N
Sbjct: 474 EVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFF 533
Query: 737 SLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVW 796
SL + + L+ LD S N I M K ++ ++L L L N F CTC+ F+
Sbjct: 534 SLDTFPYKCLNSLQVLDYSLNHI-MTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQ 592
Query: 797 WVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVM 856
W+ + + + C P +G V+SL++ TC+++ T + + LS+ V + V+
Sbjct: 593 WIKDQRQLLVEVER-MECATPSDKQGMPVLSLNI-TCQMNKTIIGVSVLSVLVVSVVAVL 650
Query: 857 MTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKL 916
+ Y ++F + G + + YDAF++Y ++D +WV ELV L
Sbjct: 651 V-----------YKFYFHLMLLAGCIKYGRGENIYDAFVIYSSQD---EDWVRNELVKNL 696
Query: 917 EDPREKHFNLCLEERDWLPGQPVLEN-LSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSH 975
E+ F LCL RD++PG + N + + S+K + V++ + ++ + ++
Sbjct: 697 EE-GVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQ 755
Query: 976 Q-RLMDEKVDVIILIF--LEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNA 1032
+ + + +I ++ +EK + + ++L + L ++ LEW + FW+ L+ A
Sbjct: 756 TWQFLSSRAGIIFIVLQKVEKTLLRQQ-VELYRLLSRNTYLEWEDSVLGRHIFWRRLRKA 814
Query: 1033 L 1033
L
Sbjct: 815 L 815
Score = 84.7 bits (208), Expect = 4e-16
Identities = 143/615 (23%), Positives = 229/615 (37%), Gaps = 127/615 (20%)
Query: 46 HVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDF-RCNCVPIP 104
++ C + + +IP +P +T NL L+ N + + SF L +D RC I
Sbjct: 35 NITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIE 94
Query: 105 LGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQLLSLEANNIF 161
G+ + L++L +L L GN + + G SLQ L N+
Sbjct: 95 DGA---------------YQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLA 139
Query: 162 SIRKENLTELANIEILYLGQNCY--YRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAV 219
S+ + L ++ L + N ++ P Y F NLT L+ L L N + ++
Sbjct: 140 SLENFPIGHLKTLKELNVAHNLIQSFKLPEY---------FSNLTNLEHLDLSSNKIQSI 190
Query: 220 PTVLPSTLTELYLYN-------NMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAP 272
L ++ L N N + IQ F + +L L L N
Sbjct: 191 YCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEI-RLHKLTLRNNF------------ 237
Query: 273 CKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQ-----NFLA 327
L + L L+V RL F+N L++ D S N
Sbjct: 238 ----DSLNVMKTCIQGLAGLEVHRLVLGE--------FRNEGNLEKFDKSALEGLCNLTI 285
Query: 328 KEIGDAKFLHFLPSLIQL---------------------DLSFNFELQVYRASMNLSQAF 366
+E A ++L +I L D S+NF Q ++ F
Sbjct: 286 EEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLEL---VNCKF 342
Query: 367 SSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF--KRLK 424
+LK+ ++ F K N +L +LE LDL N + F LK
Sbjct: 343 GQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLK 402
Query: 425 VIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHY--FRYDKYARSCRFKNKEA 482
+DLS N + S+ +G LEQL + F++ + F +
Sbjct: 403 YLDLSFNGVITMS-SNFLG----------------LEQLEHLDFQHSNLKQMSEF----S 441
Query: 483 SFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLA 542
F+S+ Y LD+S + F LS L+ L ++GN + F L
Sbjct: 442 VFLSLRNLIY-----LDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELR 496
Query: 543 ELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLM 602
L +LD S +L+ L TAF L L+VL++S N ++F + + K L LQ L
Sbjct: 497 NLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN-NFFSLDTFPY-----KCLNSLQVLD 550
Query: 603 MNDNDISSSTSRTME 617
+ N I +S + ++
Sbjct: 551 YSLNHIMTSKKQELQ 565
>gi|62865621 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 133 bits (335), Expect = 8e-31
Identities = 185/784 (23%), Positives = 334/784 (42%), Gaps = 92/784 (11%)
Query: 276 NSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKF 335
N Q+ + F ++++L+VL L N +Q + + F+ +L+ LDLS N L
Sbjct: 58 NLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTW---- 113
Query: 336 LHFLPSLIQLDLSFN-FELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLH 394
+ L L LDLSFN F+ +M + + ++ L+IL + G ++
Sbjct: 114 -YLLAGLRYLDLSFNDFD------TMPICEEAGNMSHLEILGLSGAKIQK---------S 157
Query: 395 NLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVES 454
+ Q + L L T F+ L +++ + ++ + P + V +TS
Sbjct: 158 DFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKIL 217
Query: 455 YEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIF----FVKS 510
+ + + Y+ R+ +N + S + +N+ +DL + +F FV
Sbjct: 218 EMTNIDGKSQFVSYEMQ-RNLSLENAKTSVLLLNK--------VDLLWDDLFLILQFVWH 268
Query: 511 SDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNN-----RLDLLHSTAF--- 562
+ +H + + T G + + D+SN +L+ +H F
Sbjct: 269 TSVEHFQ----------IRNVTFGGKAY---LDHNSFDYSNTVMRTIKLEHVHFRVFYIQ 315
Query: 563 EELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSST-SRTMESESL 621
++ L + + + + + HML F Q L +N ++ RT++ L
Sbjct: 316 QDKIYLLLTKMDIENLTISNAQMPHML-FPNYPTKFQYLNFANNILTDELFKRTIQLPHL 374
Query: 622 RTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLS 681
+TL GN L+ L + F N LE LD+S+N L + P + N++
Sbjct: 375 KTLILNGNKLETL------SLVSCFANNTPLEHLDLSQNLLQH-KNDENCSWPETVVNMN 427
Query: 682 LAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKY 741
L+ N L ++ L K+++ LDL++NQ+ TVP+ + +L+ L + N + L
Sbjct: 428 LSYNKLSDSVFRCLP--KSIQILDLNNNQIQTVPKETIHLM-ALRELNIAFNFLTDLPG- 483
Query: 742 FLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHT 801
+L L++ N I + F ++ +K L N F CTC+ F+ ++
Sbjct: 484 -CSHFSRLSVLNIEMNFI-LSPSLDFVQSC-QEVKTLNAGRNPFRCTCELKNFIQLETYS 540
Query: 802 EVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASH 861
EV + + TC P +G + + L+ EL +L + + L L + +
Sbjct: 541 EVMMVGWSDSYTCEYPLNLRGTRLKDVHLH--ELSCNTALLIVTIVVIMLVLGLAVAFCC 598
Query: 862 LYFWDVWYI---------YHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAEL 912
L+F WY+ +H + K Q + + + AFI Y D WV EL
Sbjct: 599 LHFDLPWYLRMLGQCTQTWHRVR---KTTQEQLKRNVRFHAFISYSEHDSL---WVKNEL 652
Query: 913 VAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFY 972
+ LE + +CL E + PG+ + EN+ I+ S K++FV++ + + E FY
Sbjct: 653 IPNLEK-EDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFY 711
Query: 973 LSHQRLMDEKVDVIILIFLEK-PFQ--KSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCL 1029
+H L E D IILI LE PF +++ +L+ L + LEWP + + FW L
Sbjct: 712 FAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANL 771
Query: 1030 KNAL 1033
+ A+
Sbjct: 772 RAAI 775
Score = 54.3 bits (129), Expect = 6e-07
Identities = 72/244 (29%), Positives = 112/244 (45%), Gaps = 16/244 (6%)
Query: 497 TLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDL 556
TLDLS N +F ++SSDF +S L+ L L N I Q L+ F+ ELRYLD SNNR
Sbjct: 52 TLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQ-LDLKTFEFNKELRYLDLSNNR--- 107
Query: 557 LHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTM 616
L S + L L LD+S N F + I N+ L+ L ++ I S + +
Sbjct: 108 LKSVTWYLLAGLRYLDLSFND--FDTMPICEEAG---NMSHLEILGLSGAKIQKSDFQKI 162
Query: 617 ESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLE-ELDISKNSLSFLPSGVFDGMPP 675
L T+ F G + EG L N KL L + N L G+
Sbjct: 163 AHLHLNTV-FLGFRTLPHYEEGSLPIL----NTTKLHIVLPMDTNFWVLLRDGIKTSKIL 217
Query: 676 NLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQI 735
+ N+ K+ S+ ++ L+N +T L N++ + + L + + + +++ QI
Sbjct: 218 EMTNID-GKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQI 276
Query: 736 RSLT 739
R++T
Sbjct: 277 RNVT 280
Score = 42.7 bits (99), Expect = 0.002
Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 653 EELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLT 712
EE ++ N + V + P L L+ N L + L L L HN++
Sbjct: 26 EERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQ 85
Query: 713 TVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSN 757
+ + ++ L+ L L NN+++S+T Y L LRYLDLS N
Sbjct: 86 QLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAG---LRYLDLSFN 127
Score = 37.7 bits (86), Expect = 0.057
Identities = 22/60 (36%), Positives = 36/60 (60%)
Query: 703 TLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMI 762
TLDLS+N L + + L+ LIL +N+I+ L + +LRYLDLS+N+++ +
Sbjct: 52 TLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSV 111
Score = 33.1 bits (74), Expect = 1.4
Identities = 40/187 (21%), Positives = 78/187 (41%), Gaps = 21/187 (11%)
Query: 44 KNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPI 103
+ ++ +C++ L ++P + TT L L+ N + + + FH + L +
Sbjct: 27 ERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVL--------- 77
Query: 104 PLGSKNNMCIKRL-QIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFS 162
+C R+ Q+ ++F L+ L L N+L + L L+ L L N+ +
Sbjct: 78 ------ILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDT 131
Query: 163 IR-KENLTELANIEILYLG----QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVT 217
+ E ++++EIL L Q ++ ++ + F L + SL N T
Sbjct: 132 MPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTT 191
Query: 218 AVPTVLP 224
+ VLP
Sbjct: 192 KLHIVLP 198
>gi|62865618 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 133 bits (335), Expect = 8e-31
Identities = 185/784 (23%), Positives = 334/784 (42%), Gaps = 92/784 (11%)
Query: 276 NSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKF 335
N Q+ + F ++++L+VL L N +Q + + F+ +L+ LDLS N L
Sbjct: 58 NLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTW---- 113
Query: 336 LHFLPSLIQLDLSFN-FELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLH 394
+ L L LDLSFN F+ +M + + ++ L+IL + G ++
Sbjct: 114 -YLLAGLRYLDLSFNDFD------TMPICEEAGNMSHLEILGLSGAKIQK---------S 157
Query: 395 NLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVES 454
+ Q + L L T F+ L +++ + ++ + P + V +TS
Sbjct: 158 DFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKIL 217
Query: 455 YEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIF----FVKS 510
+ + + Y+ R+ +N + S + +N+ +DL + +F FV
Sbjct: 218 EMTNIDGKSQFVSYEMQ-RNLSLENAKTSVLLLNK--------VDLLWDDLFLILQFVWH 268
Query: 511 SDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNN-----RLDLLHSTAF--- 562
+ +H + + T G + + D+SN +L+ +H F
Sbjct: 269 TSVEHFQ----------IRNVTFGGKAY---LDHNSFDYSNTVMRTIKLEHVHFRVFYIQ 315
Query: 563 EELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSST-SRTMESESL 621
++ L + + + + + HML F Q L +N ++ RT++ L
Sbjct: 316 QDKIYLLLTKMDIENLTISNAQMPHML-FPNYPTKFQYLNFANNILTDELFKRTIQLPHL 374
Query: 622 RTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLS 681
+TL GN L+ L + F N LE LD+S+N L + P + N++
Sbjct: 375 KTLILNGNKLETL------SLVSCFANNTPLEHLDLSQNLLQH-KNDENCSWPETVVNMN 427
Query: 682 LAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKY 741
L+ N L ++ L K+++ LDL++NQ+ TVP+ + +L+ L + N + L
Sbjct: 428 LSYNKLSDSVFRCLP--KSIQILDLNNNQIQTVPKETIHLM-ALRELNIAFNFLTDLPG- 483
Query: 742 FLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHT 801
+L L++ N I + F ++ +K L N F CTC+ F+ ++
Sbjct: 484 -CSHFSRLSVLNIEMNFI-LSPSLDFVQSC-QEVKTLNAGRNPFRCTCELKNFIQLETYS 540
Query: 802 EVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASH 861
EV + + TC P +G + + L+ EL +L + + L L + +
Sbjct: 541 EVMMVGWSDSYTCEYPLNLRGTRLKDVHLH--ELSCNTALLIVTIVVIMLVLGLAVAFCC 598
Query: 862 LYFWDVWYI---------YHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAEL 912
L+F WY+ +H + K Q + + + AFI Y D WV EL
Sbjct: 599 LHFDLPWYLRMLGQCTQTWHRVR---KTTQEQLKRNVRFHAFISYSEHDSL---WVKNEL 652
Query: 913 VAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFY 972
+ LE + +CL E + PG+ + EN+ I+ S K++FV++ + + E FY
Sbjct: 653 IPNLEK-EDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFY 711
Query: 973 LSHQRLMDEKVDVIILIFLEK-PFQ--KSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCL 1029
+H L E D IILI LE PF +++ +L+ L + LEWP + + FW L
Sbjct: 712 FAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANL 771
Query: 1030 KNAL 1033
+ A+
Sbjct: 772 RAAI 775
Score = 54.3 bits (129), Expect = 6e-07
Identities = 72/244 (29%), Positives = 112/244 (45%), Gaps = 16/244 (6%)
Query: 497 TLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDL 556
TLDLS N +F ++SSDF +S L+ L L N I Q L+ F+ ELRYLD SNNR
Sbjct: 52 TLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQ-LDLKTFEFNKELRYLDLSNNR--- 107
Query: 557 LHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTM 616
L S + L L LD+S N F + I N+ L+ L ++ I S + +
Sbjct: 108 LKSVTWYLLAGLRYLDLSFND--FDTMPICEEAG---NMSHLEILGLSGAKIQKSDFQKI 162
Query: 617 ESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLE-ELDISKNSLSFLPSGVFDGMPP 675
L T+ F G + EG L N KL L + N L G+
Sbjct: 163 AHLHLNTV-FLGFRTLPHYEEGSLPIL----NTTKLHIVLPMDTNFWVLLRDGIKTSKIL 217
Query: 676 NLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQI 735
+ N+ K+ S+ ++ L+N +T L N++ + + L + + + +++ QI
Sbjct: 218 EMTNID-GKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQI 276
Query: 736 RSLT 739
R++T
Sbjct: 277 RNVT 280
Score = 42.7 bits (99), Expect = 0.002
Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 653 EELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLT 712
EE ++ N + V + P L L+ N L + L L L HN++
Sbjct: 26 EERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQ 85
Query: 713 TVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSN 757
+ + ++ L+ L L NN+++S+T Y L LRYLDLS N
Sbjct: 86 QLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAG---LRYLDLSFN 127
Score = 37.7 bits (86), Expect = 0.057
Identities = 22/60 (36%), Positives = 36/60 (60%)
Query: 703 TLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMI 762
TLDLS+N L + + L+ LIL +N+I+ L + +LRYLDLS+N+++ +
Sbjct: 52 TLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSV 111
Score = 33.1 bits (74), Expect = 1.4
Identities = 40/187 (21%), Positives = 78/187 (41%), Gaps = 21/187 (11%)
Query: 44 KNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPI 103
+ ++ +C++ L ++P + TT L L+ N + + + FH + L +
Sbjct: 27 ERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVL--------- 77
Query: 104 PLGSKNNMCIKRL-QIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFS 162
+C R+ Q+ ++F L+ L L N+L + L L+ L L N+ +
Sbjct: 78 ------ILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDT 131
Query: 163 IR-KENLTELANIEILYLG----QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVT 217
+ E ++++EIL L Q ++ ++ + F L + SL N T
Sbjct: 132 MPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTT 191
Query: 218 AVPTVLP 224
+ VLP
Sbjct: 192 KLHIVLP 198
>gi|41350337 toll-like receptor 1 [Homo sapiens]
Length = 786
Score = 131 bits (329), Expect = 4e-30
Identities = 188/803 (23%), Positives = 326/803 (40%), Gaps = 150/803 (18%)
Query: 288 ALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDL 347
+L++L++L + N +Q++ FK +L+ LDLS N L K H +L LDL
Sbjct: 67 SLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKIS-----CHPTVNLKHLDL 121
Query: 348 SFNF--ELQVYRASMNLSQA-----------------FSSLKSLKILRIRGYVFKE---- 384
SFN L + + N+SQ + L K+L + G + E
Sbjct: 122 SFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDP 181
Query: 385 --LKSFNLSPLH-----NLQNLEVLDLGTNFI---KIANLSMFKQFKRLKVIDLSVNKIS 434
L+ FN LH N + +LD+ + +++N+ + + + K+
Sbjct: 182 EGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQ 241
Query: 435 PSGDSSEVGFCSNARTSVESYEPQVLEQLH----YFRYDKYARSCRFKNKEASFMSVNES 490
+ S + +N T+ S+ + H YF + ++ + +
Sbjct: 242 TNPKLSNLTL-NNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLK 300
Query: 491 CYKYGQTLDLSKNSIF-FVKSSDFQHLSFLKCLN--LSGNLISQTLNGSEFQPLAELRYL 547
Q + + +F F +S ++ S + N +SG + L S+ P +L
Sbjct: 301 ALSIHQVV----SDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFL---HL 353
Query: 548 DFSNNRLDLLHSTAFEE---LHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMN 604
DFSNN LL T FE L +LE L + N Q + ++ + T +K LQ+L ++
Sbjct: 354 DFSNN---LLTDTVFENCGHLTELETLILQMN----QLKELSKIAEMTTQMKSLQQLDIS 406
Query: 605 DNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSF 664
N +S + D W K+LL L S +
Sbjct: 407 QNSVSYDEKKG----------------DCSWT----------KSLLSLNM------SSNI 434
Query: 665 LPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRS 724
L +F +PP +K L L N +KS K++ L+ L+ L+++ N LT +P S S S
Sbjct: 435 LTDTIFRCLPPRIKVLDLHSNKIKSIP-KQVVKLEALQELNVAFNSLTDLPGCGSFSSLS 493
Query: 725 LKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNR 784
+ LI+ +N + + F Q ++R + N Q
Sbjct: 494 V--LIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQ------------------------ 527
Query: 785 FLCTCDAVWFVWWVNHTEVTIPYLATD-VTCVGPGAHKGQSVISLDLYTCELDLTNLILF 843
CTC+ FV ++ + D C P +++G + D + EL +L
Sbjct: 528 --CTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRG--TLLKDFHMSELSCNITLLI 583
Query: 844 SLSISVSLFLMVMMTASHLYFWDVWYIYHFCK----------AKIKGYQRLISPDCCYDA 893
++ L L V +T+ Y WY+ C+ ++ QR + + A
Sbjct: 584 VTIVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQ----FHA 639
Query: 894 FIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKT 953
FI Y D + WV EL+ LE ++ +CL ER+++PG+ ++EN+ I+ S K+
Sbjct: 640 FISYSGHD---SFWVKNELLPNLE---KEGMQICLHERNFVPGKSIVENIITCIEKSYKS 693
Query: 954 VFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQ---KSKFLQLRKRLCGS 1010
+FV++ + ++E Y +H L E + +ILI LE Q S + +L+ +
Sbjct: 694 IFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARR 753
Query: 1011 SVLEWPTNPQAHPYFWQCLKNAL 1033
+ LEWP FW L+ A+
Sbjct: 754 TYLEWPKEKSKRGLFWANLRAAI 776
Score = 42.0 bits (97), Expect = 0.003
Identities = 107/474 (22%), Positives = 189/474 (39%), Gaps = 77/474 (16%)
Query: 343 IQLDLSFNFELQVYRASMNLSQAFSSL-KSLKILRIRGYVFKELKSFNLSPLHNLQNLEV 401
I++ LS E V R+ L L + IL I EL + S + +L L +
Sbjct: 17 IRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWT---SDILSLSKLRI 73
Query: 402 LDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLE 461
L + N I+ ++S+FK + L+ +DLS NK+ V + +++ +
Sbjct: 74 LIISHNRIQYLDISVFKFNQELEYLDLSHNKL--------VKISCHPTVNLKHLD----- 120
Query: 462 QLHYFRYDKYARSCRFKN-KEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLK 520
L + +D F N + F+ ++ T L K+S+ HL+ K
Sbjct: 121 -LSFNAFDALPICKEFGNMSQLKFLGLS--------TTHLEKSSVL-----PIAHLNISK 166
Query: 521 CLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEV-------LDI 573
L + G + + Q DF+ L ++ T E L+V L++
Sbjct: 167 VLLVLGETYGEKEDPEGLQ--------DFNTESLHIVFPTNKEFHFILDVSVKTVANLEL 218
Query: 574 SSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDV 633
S+ + ++ L+ L+ KL ++++ + T + +R L+ H V
Sbjct: 219 SNIKCVLEDNKCSYFLSILAKLQTNPKL----SNLTLNNIETTWNSFIRILQLVW-HTTV 273
Query: 634 LWREGDNRYLQLFKNLLKLEELDISKNSLSFLP-----SGVFDGMPPN-----LKNLSLA 683
+ N LQ L + D S SL L S VF G P + N+++
Sbjct: 274 WYFSISNVKLQ---GQLDFRDFDYSGTSLKALSIHQVVSDVF-GFPQSYIYEIFSNMNIK 329
Query: 684 KNGLKSFSWKKLQCLKNLET---LDLSHNQLT-TVPERLSNCSRSLKNLILKNNQIRSLT 739
+ + C + LD S+N LT TV E + + L+ LIL+ NQ++ L+
Sbjct: 330 NFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLT-ELETLILQMNQLKELS 388
Query: 740 KY--FLQDAFQLRYLDLSSNKIQMIQK---TSFPENVLN-NLKMLLLHHNRFLC 787
K L+ LD+S N + +K S+ +++L+ N+ +L F C
Sbjct: 389 KIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRC 442
Score = 33.1 bits (74), Expect = 1.4
Identities = 41/155 (26%), Positives = 67/155 (43%), Gaps = 16/155 (10%)
Query: 227 LTELYLYNNMIAKIQE--DDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVN 284
L L L N + ++ + + + LQ LD+S N C+ K+ L + N
Sbjct: 374 LETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSN 433
Query: 285 AF-DAL-----TELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHF 338
D + +KVL LHSN ++ +P + K + LQEL+++ N L G F
Sbjct: 434 ILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVK-LEALQELNVAFNSLTDLPGCGSF--- 489
Query: 339 LPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLK 373
SL L + N V S + Q+ ++S+K
Sbjct: 490 -SSLSVLIIDHN---SVSHPSADFFQSCQKMRSIK 520
>gi|20143971 toll-like receptor 6 [Homo sapiens]
Length = 796
Score = 130 bits (327), Expect = 6e-30
Identities = 186/815 (22%), Positives = 337/815 (41%), Gaps = 144/815 (17%)
Query: 280 QIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFL 339
++ V+ L+EL VLRL N +Q + FK L+ LDLS N L K H +
Sbjct: 66 ELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKIS-----CHPI 120
Query: 340 PSLIQLDLSFNF--ELQVYRASMNLSQA-FSSLKSLKILRIR---------GYVFKELKS 387
S LDLSFN L + + NLSQ F L ++K+ ++ Y+ +L++
Sbjct: 121 VSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRN 180
Query: 388 FNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSN 447
+ + + ++L++L+ T + S+F +++SVN + G
Sbjct: 181 YYIKE-NETESLQILNAKTLHLVFHPTSLFAI-----QVNISVNTL---------GCLQL 225
Query: 448 ARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFF 507
+ QV + + R N + + C
Sbjct: 226 TNIKLNDDNCQVFIKF----LSELTRGSTLLNFTLNHIETTWKC---------------L 266
Query: 508 VKSSDFQHLSFLKCLNLSGNLISQTLNGSEF---QPLAELRYLDFSNNRLDLLHSTA--- 561
V+ F ++ LN+ I +++ +F + + ++ N++ L TA
Sbjct: 267 VRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYT 326
Query: 562 -FEELHKLEVLDISSNSHYFQ----SEGITHMLNFTKN------------LKVLQKLMMN 604
F E++ + +L IS + LNFT+N L L+ L++
Sbjct: 327 VFSEMN-IMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQ 385
Query: 605 DNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSF 664
N + + ++ + +LE LDV W ++ + +N +E + + S +
Sbjct: 386 KNGLKDLFKVGLMTKDMPSLEI----LDVSWNSLESGRHK--ENCTWVESIVVLNLSSNM 439
Query: 665 LPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRS 724
L VF +PP +K L L N +KS K++ L+ L+ L+++ N LT +P S S S
Sbjct: 440 LTDSVFRCLPPRIKVLDLHSNKIKSVP-KQVVKLEALQELNVAFNSLTDLPGCGSFSSLS 498
Query: 725 LKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNR 784
+ LI+ +N + + F Q ++R + N Q
Sbjct: 499 V--LIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQ------------------------ 532
Query: 785 FLCTCDAVWFVWWVNHTEVTIPYLATD-VTCVGPGAHKGQSVISLDLYTCELDLTNLILF 843
CTC+ FV ++ + D C P +++G + D + EL N+ L
Sbjct: 533 --CTCELREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPL--KDFHMSELSC-NITLL 587
Query: 844 SLSISVSLFLMVMMTASHLYFWDV-WYIYHFCK----------AKIKGYQRLISPDCCYD 892
++I ++ ++ + S + D+ WY+ C+ ++ QR + +
Sbjct: 588 IVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQ----FH 643
Query: 893 AFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKK 952
AFI Y D A WV +ELV LE ++ +CL ER+++PG+ ++EN+ I+ S K
Sbjct: 644 AFISYSEHDSA---WVKSELVPYLE---KEDIQICLHERNFVPGKSIVENIINCIEKSYK 697
Query: 953 TVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKS---KFLQLRKRLCG 1009
++FV++ + ++E Y +H L E + +ILI LE Q S K+ +L+ +
Sbjct: 698 SIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQ 757
Query: 1010 SSVLEWPTNPQAHPYFWQCLKNA------LATDNH 1038
+ L+WP FW ++ A L T+N+
Sbjct: 758 RTYLQWPKEKSKRGLFWANIRAAFNMKLTLVTENN 792
Score = 38.5 bits (88), Expect = 0.033
Identities = 26/59 (44%), Positives = 36/59 (61%), Gaps = 1/59 (1%)
Query: 496 QTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRL 554
+ LD+S+N I ++ SD LS L L LS N I Q L+ S F+ +L YLD S+N+L
Sbjct: 55 KVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRI-QLLDLSVFKFNQDLEYLDLSHNQL 112
Score = 37.7 bits (86), Expect = 0.057
Identities = 27/108 (25%), Positives = 50/108 (46%), Gaps = 7/108 (6%)
Query: 655 LDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTV 714
+D SK L +P +P K L +++N + + L L L LSHN++ +
Sbjct: 36 VDKSKRGLIHVPKD----LPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLL 91
Query: 715 PERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMI 762
+ ++ L+ L L +NQ++ ++ R+LDLS N + +
Sbjct: 92 DLSVFKFNQDLEYLDLSHNQLQKIS---CHPIVSFRHLDLSFNDFKAL 136
Score = 36.6 bits (83), Expect = 0.13
Identities = 23/57 (40%), Positives = 34/57 (59%), Gaps = 1/57 (1%)
Query: 520 KCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN 576
K L++S N I++ L S+ L+EL L S+NR+ LL + F+ LE LD+S N
Sbjct: 55 KVLDMSQNYIAE-LQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHN 110
Score = 32.7 bits (73), Expect = 1.8
Identities = 44/177 (24%), Positives = 77/177 (43%), Gaps = 33/177 (18%)
Query: 203 LTKLKVLSLKDNNVTAVPTV------LPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDL 256
L KL+ L L+ N + + V +PS +N++ + +++ + + +L+L
Sbjct: 376 LVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNL 435
Query: 257 SGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKL 316
S N ++ F C P + +KVL LHSN ++ VP + K + L
Sbjct: 436 SSNM--LTDSVFRCLPPR-----------------IKVLDLHSNKIKSVPKQVVK-LEAL 475
Query: 317 QELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLK 373
QEL+++ N L G F SL L + N V S + Q+ ++S+K
Sbjct: 476 QELNVAFNSLTDLPGCGSF----SSLSVLIIDHN---SVSHPSADFFQSCQKMRSIK 525
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 124 bits (310), Expect = 6e-28
Identities = 212/933 (22%), Positives = 355/933 (38%), Gaps = 185/933 (19%)
Query: 25 LGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPAS 84
LGA P C T VDC L IP IP NT L L N+I I
Sbjct: 29 LGASACPALCTCTGTT--------VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKND 80
Query: 85 FHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQ 144
F L L + N + ++ +F + L+ L L+ NQL +P+
Sbjct: 81 FAGLKQLRVLQLMENQIG--------------AVERGAFDDMKELERLRLNRNQLHMLPE 126
Query: 145 GLPPSLQLLS---LEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFL 201
L + Q LS L N I +I ++ +++ L L +N + C IE+ AF
Sbjct: 127 LLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKN---QISC-----IEEGAFR 178
Query: 202 NLTKLKVLSLKDNNVTAVPTV----LPSTLTELYLYNNM--------------------- 236
L L+VL+L +NN+T +P +P T N++
Sbjct: 179 ALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGL 238
Query: 237 --------------IAKIQEDDFNNLNQLQILDL------SGNCPRCYNAPFPCAPCKNN 276
+A++Q+ +F+ Q + + SG+CP C+
Sbjct: 239 FTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGK 298
Query: 277 SPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFL 336
IP N + +TE +RL N ++ +PP F KL+ +DLS N +A+ DA
Sbjct: 299 GLTAIPANLPETMTE---IRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDA--F 353
Query: 337 HFLPSLIQLDLSFN-------------FELQVYRASMN-----LSQAFSSLKSLKILRIR 378
L SL L L N + LQ+ + N AF L++L +L +
Sbjct: 354 QGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLY 413
Query: 379 GYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSG- 437
+ L + L +Q L + FI NL F R I+ S + +
Sbjct: 414 DNKIQSLAKGTFTSLRAIQTLHLAQ--NPFICDCNLKWLADFLRTNPIETSGARCASPRR 471
Query: 438 -DSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARS---------CRFKNKEASFMSV 487
+ +G + + + E + ++ + S C E S + +
Sbjct: 472 LANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKL 531
Query: 488 NESCYKYGQT---LDLSKNSIFFVKSSD-FQHLSFLKCLNLSGNLISQTLNGSEFQPLAE 543
+ + Q+ L L+ N I ++++ F+ L+ LK +NLS N +S+ +G+ F+ A
Sbjct: 532 TKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGA-FEGAAS 590
Query: 544 LRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMM 603
+ L + N+L+ + S F L L L + +N H +FT L+ ++ L +
Sbjct: 591 VSELHLTANQLESIRSGMFRGLDGLRTLMLRNN-----RISCIHNDSFT-GLRNVRLLSL 644
Query: 604 NDNDISSSTSRTMES-ESLRTLEFRGN----HLDVLWREGDNRYLQL-----------FK 647
DN I++ + ++ +SL TL N + + W G R ++ F
Sbjct: 645 YDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFL 704
Query: 648 NLLKLEELDI---------------------------------SKNSLSFLPSGVFDGMP 674
+ L+++ S L LP G+ P
Sbjct: 705 RQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGI----P 760
Query: 675 PNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQ 734
N+ L L N + +L K L+ +DLS+N+++++ L LIL N
Sbjct: 761 KNVTELYLDGNQF-TLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNA 819
Query: 735 IRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWF 794
++ + Q LR L L N I +Q+ F + + +L L + N C C W
Sbjct: 820 LQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFAD--VTSLSHLAIGANPLYCDCHLRWL 877
Query: 795 VWWVNHTEVTIPYLATDVTCVGPGAHKGQSVIS 827
WV T P +A C GP +G+ +++
Sbjct: 878 SSWVK-TGYKEPGIA---RCAGPQDMEGKLLLT 906
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 123 bits (309), Expect = 8e-28
Identities = 198/880 (22%), Positives = 332/880 (37%), Gaps = 182/880 (20%)
Query: 49 VDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSK 108
VDC L +P GIP N L L N+I I+ F L +L + N V +
Sbjct: 45 VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSV----- 99
Query: 109 NNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQLLSLEANNIFSIRK 165
I+ +F L L+ L L+ N+L +P+ L P L L L N I I +
Sbjct: 100 ---------IERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPR 150
Query: 166 ENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAV------ 219
+ + +++ L L N ++S IE AF L L++L+L +NN++ +
Sbjct: 151 KAFRGITDVKNLQLDNN-------HIS-CIEDGAFRALRDLEILTLNNNNISRILVTSFN 202
Query: 220 --PTVLPSTLTELYLYNNMIAKIQEDDFN---------------NLNQLQILDLSGN--- 259
P + L +LY + D +L + D+
Sbjct: 203 HMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYV 262
Query: 260 CPRCYNAPFPC-----------------APCKNNSPLQIPVNAFDALTELKVLRLHSNSL 302
CP ++ P C C+ ++IP N + + E+ RL NS+
Sbjct: 263 CPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEI---RLEQNSI 319
Query: 303 QHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNL 362
+ +P F KL+ +D+S+N ++ DA L SL L L N ++ +
Sbjct: 320 KAIPAGAFTQYKKLKRIDISKNQISDIAPDA--FQGLKSLTSLVLYGNKITEIAKG---- 373
Query: 363 SQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKR 422
F L SL++L + ++ ++ +LQNL +L L N ++ + +F +
Sbjct: 374 --LFDGLVSLQLLLLNA---NKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQS 428
Query: 423 LKVIDLSVNK-------------ISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYD 469
++ + L+ N + + + CS+ R Q+ +
Sbjct: 429 IQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGS 488
Query: 470 KYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKS------------------- 510
+ RS RF ++ + E C G +D S + + S
Sbjct: 489 EDYRS-RFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVL 547
Query: 511 ---SDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHK 567
F+ L L+ +NLS N I + G+ F A ++ L + N+L+ +H F L
Sbjct: 548 EATGIFKKLPNLRKINLSNNKIKEVREGA-FDGAASVQELMLTGNQLETVHGRVFRGLSG 606
Query: 568 LEVLDISSNSHYFQSEGITHMLNFT-KNLKVLQKLMMNDNDISSSTSRTMES-ESLRTLE 625
L+ L + SN I + N T L ++ L + DN I++ T + SL T+
Sbjct: 607 LKTLMLRSNL-------IGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTIN 659
Query: 626 FRGN------HLDVLWR--------EGDNRYLQ-LFKNLLKLEELDI------------- 657
N HL L + G+ R + F + ++++ I
Sbjct: 660 LLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSC 719
Query: 658 -------------------SKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCL 698
S L LP G MP ++ L L N L + ++L L
Sbjct: 720 QLSPRCPEQCTCMETVVRCSNKGLRALPRG----MPKDVTELYLEGNHLTAVP-RELSAL 774
Query: 699 KNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNK 758
++L +DLS+N ++ + + L LIL N++R + + LR L L N
Sbjct: 775 RHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGND 834
Query: 759 IQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWV 798
I + + SF N L +L L L N C C W WV
Sbjct: 835 ISSVPEGSF--NDLTSLSHLALGTNPLHCDCSLRWLSEWV 872
Score = 90.1 bits (222), Expect = 1e-17
Identities = 116/473 (24%), Positives = 186/473 (39%), Gaps = 84/473 (17%)
Query: 397 QNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYE 456
+N E LDL N I F K L+V+ L N++S + R + +
Sbjct: 61 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK 120
Query: 457 PQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHL 516
QVL +L + K R LDLS+N I + F+ +
Sbjct: 121 LQVLPELLFQSTPKLTR------------------------LDLSENQIQGIPRKAFRGI 156
Query: 517 SFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN 576
+ +K L L N IS +G+ F+ L +L L +NN + + T+F + K+ L + SN
Sbjct: 157 TDVKNLQLDNNHISCIEDGA-FRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSN 215
Query: 577 SHYFQSE---------------------GITHMLNFTKNLKVLQKL------------MM 603
Y H+ F N+ +QK
Sbjct: 216 HLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGF--NVADVQKKEYVCPAPHSEPPSC 273
Query: 604 NDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLK-LEELDISKNSL 662
N N IS + T + ++ RG L +++ NL + + E+ + +NS+
Sbjct: 274 NANSISCPSPCTCSNN---IVDCRGKGL-----------MEIPANLPEGIVEIRLEQNSI 319
Query: 663 SFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCS 722
+P+G F LK + ++KN + + Q LK+L +L L N++T + + L +
Sbjct: 320 KAIPAGAFTQYK-KLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGL 378
Query: 723 RSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHH 782
SL+ L+L N+I L QD L L L NK+Q I K F L +++ L L
Sbjct: 379 VSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAP--LQSIQTLHLAQ 436
Query: 783 NRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPG--AHKGQSVISLDLYTC 833
N F+C C W ++ P + C P A+K S I + C
Sbjct: 437 NPFVCDCHLKWLADYLQDN----PIETSGARCSSPRRLANKRISQIKSKKFRC 485
Score = 85.1 bits (209), Expect = 3e-16
Identities = 146/597 (24%), Positives = 231/597 (38%), Gaps = 83/597 (13%)
Query: 48 IVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGS 107
IVDC K L EIP +P + L N I I +F + L ID S
Sbjct: 290 IVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDI----------S 339
Query: 108 KNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQLLSLEANNIFSIR 164
KN + I P +F GL L SL L GN++ EI +GL SLQLL L AN I +R
Sbjct: 340 KNQIS----DIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLR 395
Query: 165 KENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTA------ 218
+L N+ +L L N +I K F L ++ L L N
Sbjct: 396 VNTFQDLQNLNLLSLYDN--------KLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKW 447
Query: 219 ---------VPTVLPSTLTELYLYNNMIAKIQ---------EDDFNNLNQLQILDLSGNC 260
+ T + L N I++I+ ED + + +DL C
Sbjct: 448 LADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLV--C 505
Query: 261 PRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRW-FKNINKLQEL 319
P C N ++IP + + +T+ LRL+ N + + FK + L+++
Sbjct: 506 PEKCRCEGTIVDCSNQKLVRIPSHLPEYVTD---LRLNDNEVSVLEATGIFKKLPNLRKI 562
Query: 320 DLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRG 379
+LS N + KE+ + F S+ +L L+ N V+ + F L LK L +R
Sbjct: 563 NLSNNKI-KEVREGAF-DGAASVQELMLTGNQLETVH------GRVFRGLSGLKTLMLRS 614
Query: 380 YVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDS 439
+ + + + L ++ +L L N I F L I+L N + +
Sbjct: 615 NLIGCVSNDTFA---GLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHL 671
Query: 440 SEVGFCSNARTSVES----YEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVN--ESCYK 493
+ +G R V +P L+++ +C + + +S E C
Sbjct: 672 AWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTC 731
Query: 494 YGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNR 553
+ S + + + ++ L L GN + T E L L +D SNN
Sbjct: 732 METVVRCSNKGLRALPRGMPKDVTE---LYLEGNHL--TAVPRELSALRHLTLIDLSNNS 786
Query: 554 LDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISS 610
+ +L + F + L L +S N H N ++L+V L ++ NDISS
Sbjct: 787 ISMLTNYTFSNMSHLSTLILSYNRLRCIP---VHAFNGLRSLRV---LTLHGNDISS 837
Score = 80.9 bits (198), Expect = 6e-15
Identities = 86/358 (24%), Positives = 152/358 (42%), Gaps = 50/358 (13%)
Query: 492 YKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSN 551
YK + +D+SKN I + FQ L L L L GN I++ G F L L+ L +
Sbjct: 330 YKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGL-FDGLVSLQLLLLNA 388
Query: 552 NRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLM--------- 602
N+++ L F++L L +L + N S+G+ L + L + Q
Sbjct: 389 NKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWL 448
Query: 603 ---MNDNDISSSTSRTMESESL--------RTLEFRGN-------------HLDVLWRE- 637
+ DN I +S +R L ++ +FR + +D++ E
Sbjct: 449 ADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEK 508
Query: 638 ----------GDNRYLQLFKNLLK-LEELDISKNSLSFL-PSGVFDGMPPNLKNLSLAKN 685
+ + +++ +L + + +L ++ N +S L +G+F + PNL+ ++L+ N
Sbjct: 509 CRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKL-PNLRKINLSNN 567
Query: 686 GLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQD 745
+K +++ L L+ NQL TV R+ LK L+L++N I ++
Sbjct: 568 KIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAG 627
Query: 746 AFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEV 803
+R L L N+I I +F L +L + L N F C C W W+ +
Sbjct: 628 LSSVRLLSLYDNRITTITPGAF--TTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRI 683
Score = 65.1 bits (157), Expect = 3e-10
Identities = 88/351 (25%), Positives = 141/351 (40%), Gaps = 82/351 (23%)
Query: 48 IVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPAS-FHRLDHLVEIDFRCNCVP---- 102
IVDC+++ L IP +P T+L L N + + F +L +L +I+ N +
Sbjct: 515 IVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVRE 574
Query: 103 ---IPLGSKNNMCIKRLQIKP---RSFSGLTYLKSLYLDGNQLLEIPQ----GLPPSLQL 152
S + + Q++ R F GL+ LK+L L N + + GL S++L
Sbjct: 575 GAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGL-SSVRL 633
Query: 153 LSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSY---------------SIEK 197
LSL N I +I T L ++ + L N + N C++++ +K
Sbjct: 634 LSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCN-CHLAWLGKWLRKRRIVSGNPRCQK 692
Query: 198 DAFLNLTKLKVLSLKD------------------NNVTAVPTV--------------LPS 225
FL ++ ++++D T + TV +P
Sbjct: 693 PFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPK 752
Query: 226 TLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGN-CPRCYNAPFPCAPCKNNSPLQ---- 280
+TELYL N + + + + L L ++DLS N N F N S L
Sbjct: 753 DVTELYLEGNHLTAVPR-ELSALRHLTLIDLSNNSISMLTNYTF-----SNMSHLSTLIL 806
Query: 281 -------IPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQN 324
IPV+AF+ L L+VL LH N + VP F ++ L L L N
Sbjct: 807 SYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTN 857
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 115 bits (287), Expect = 3e-25
Identities = 111/365 (30%), Positives = 178/365 (48%), Gaps = 44/365 (12%)
Query: 496 QTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAE-LRYLDFSNNRL 554
++LDLS N I +K+S F + LK LNLS N I+ TL F L+ L + + NR+
Sbjct: 147 ESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRIT-TLEAGCFDNLSSSLLVVKLNRNRM 204
Query: 555 DLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSR 614
++ F+ H L+ L++ N EG+T + L L+ L M N IS
Sbjct: 205 SMIPPKIFKLPH-LQFLELKRNRIKIV-EGLTF-----QGLDSLRSLKMQRNGISKLKDG 257
Query: 615 TMES-ESLRTLEFRGNHLDVL---WREGDNRYLQLF--KNLL------------KLEELD 656
++ LE N+L + W G QL+ +N + +L ELD
Sbjct: 258 AFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELD 317
Query: 657 ISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPE 716
+S N L+ L F G+ L+ L+L N + + + L NL+TLDL +N+++ E
Sbjct: 318 LSYNQLTRLDESAFVGLSL-LERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIE 376
Query: 717 RLSNCSR---SLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLN 773
S SL LIL+ NQI+S+TK L +LDL++N I IQ+ +F +
Sbjct: 377 DASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQ---T 433
Query: 774 NLKMLLLHHNRFLCTCDAVWFVWWV--NHTEVTIPYLATDVTCVGPGAHKGQSVISLDL- 830
+LK L+L+ + LC C W + W+ N+ + ++ +V+C P GQS++++DL
Sbjct: 434 HLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSV-----NVSCAHPEWLAGQSILNVDLK 488
Query: 831 -YTCE 834
+ C+
Sbjct: 489 DFVCD 493
Score = 75.5 bits (184), Expect = 2e-13
Identities = 103/395 (26%), Positives = 161/395 (40%), Gaps = 75/395 (18%)
Query: 56 LTEIPG-GIPT-NTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVP-IPLGSKNNMC 112
LTEIP G PT N T L+L N IP+I+ + L +D N + I S M
Sbjct: 109 LTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQ 168
Query: 113 IKRLQIKPRSFSGL---------TYLKSLYLDGNQLLEIPQGL--PPSLQLLSLEANNIF 161
+K L + + L + L + L+ N++ IP + P LQ L L+ N I
Sbjct: 169 LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIK 228
Query: 162 SIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPT 221
+ L ++ L + +N + ++ AF L ++ L L+ NN+T V
Sbjct: 229 IVEGLTFQGLDSLRSLKMQRNGISK--------LKDGAFFGLNNMEELELEHNNLTRVNK 280
Query: 222 VLP---STLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSP 278
L +LY+ N I +I D + +L LDLS N
Sbjct: 281 GWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLS-----------------YNQL 323
Query: 279 LQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHF 338
++ +AF L+ L+ L L N + H+ F+ ++ LQ LDL N ++ I DA
Sbjct: 324 TRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDA----- 378
Query: 339 LPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQN 398
S+AF+ L SL L ++G ++KS L++
Sbjct: 379 ------------------------SEAFAGLTSLTKLILQG---NQIKSITKKAFIGLES 411
Query: 399 LEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKI 433
LE LDL N I + F Q LK + L+ + +
Sbjct: 412 LEHLDLNNNAIMSIQENAFSQ-THLKELILNTSSL 445
Score = 66.6 bits (161), Expect = 1e-10
Identities = 76/296 (25%), Positives = 124/296 (41%), Gaps = 65/296 (21%)
Query: 498 LDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL 557
L L N I + + Q L+ L+LS N+IS+ + S F P +L+YL+ SNNR+ L
Sbjct: 125 LSLVHNIIPEINAQALQFYPALESLDLSSNIISE-IKTSSF-PRMQLKYLNLSNNRITTL 182
Query: 558 HSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTME 617
+ F+ N + +L V++ +N N +S + +
Sbjct: 183 EAGCFD--------------------------NLSSSLLVVK---LNRNRMSMIPPKIFK 213
Query: 618 SESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNL 677
L+ LE + N + ++ EG F+ L L L + +N +S L G F G
Sbjct: 214 LPHLQFLELKRNRIKIV--EG-----LTFQGLDSLRSLKMQRNGISKLKDGAFFG----- 261
Query: 678 KNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRS 737
L N+E L+L HN LT V + R L+ L + N I
Sbjct: 262 --------------------LNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIER 301
Query: 738 LTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVW 793
++ + +L LDLS N++ + +++F L+ L+ L L NR D V+
Sbjct: 302 ISPDAWEFCQRLSELDLSYNQLTRLDESAFVG--LSLLERLNLGDNRVTHIADGVF 355
Score = 59.7 bits (143), Expect = 1e-08
Identities = 83/319 (26%), Positives = 128/319 (40%), Gaps = 58/319 (18%)
Query: 129 LKSLYLDGNQLLEIPQ-GLPPS-LQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYR 186
L+ + ++ N+L EIP G P S + LLSL N I I + L +E L L N
Sbjct: 99 LQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSN---- 154
Query: 187 NPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTV----LPSTLTELYLYNNMIAKIQE 242
+ I+ +F + +LK L+L +N +T + L S+L + L N ++ I
Sbjct: 155 ----IISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPP 209
Query: 243 DDFNNLNQLQILDLSGNCPRCYNA-------PFPCAPCKNNSPLQIPVNAFDALTELKVL 295
F L LQ L+L N + + N ++ AF L ++ L
Sbjct: 210 KIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEEL 268
Query: 296 RLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQV 355
L N+L V W + LQ+L +SQN + + DA F L +LDLS+N
Sbjct: 269 ELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDA--WEFCQRLSELDLSYN----- 321
Query: 356 YRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLS 415
+L + S L LE L+LG N +
Sbjct: 322 ----------------------------QLTRLDESAFVGLSLLERLNLGDNRVTHIADG 353
Query: 416 MFKQFKRLKVIDLSVNKIS 434
+F+ L+ +DL N+IS
Sbjct: 354 VFRFLSNLQTLDLRNNEIS 372
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 114 bits (285), Expect = 5e-25
Identities = 110/377 (29%), Positives = 174/377 (46%), Gaps = 30/377 (7%)
Query: 462 QLHYFRYDKYARSCRFKNKE---ASFMSVNESCYKYGQTLD---LSKNSIFFVKSSDFQH 515
QL FR D + R ++ E +SF++++ + + +L L+ N + + FQH
Sbjct: 84 QLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQH 143
Query: 516 LSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISS 575
L+ L+ L+L GN + Q L FQPL L+ L+ + N L L F L L+ L +S+
Sbjct: 144 LAALESLHLQGNQL-QALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSN 202
Query: 576 NSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLW 635
N+ +G+ F K L LQ+L ++ N+IS + L+ LW
Sbjct: 203 NALSGLPQGV-----FGK-LGSLQELFLDSNNISELPPQVFSQLFC---------LERLW 247
Query: 636 REGD---NRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSW 692
+ + + L +F +L L L + N L LP+G+F P L LSL N L++ +
Sbjct: 248 LQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLF-AHTPCLVGLSLTHNQLETVAE 306
Query: 693 KKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYL 752
L NL +L LS+N +T +P + L L L +N + +L Q+ +L L
Sbjct: 307 GTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELL 366
Query: 753 DLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDV 812
LS N++ + + F N NL L LH N + C C + W+ + T L
Sbjct: 367 SLSKNQLTTLPEGIFDTNY--NLFNLALHGNPWQCDCHLAYLFNWLQ--QYTDRLLNIQT 422
Query: 813 TCVGPGAHKGQSVISLD 829
C GP KGQ V +L+
Sbjct: 423 YCAGPAYLKGQVVPALN 439
Score = 72.4 bits (176), Expect = 2e-12
Identities = 69/216 (31%), Positives = 102/216 (47%), Gaps = 31/216 (14%)
Query: 117 QIKPRSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQLLSLEANNIFSIRKENLTELAN 173
Q+ F LT L++L L N L +PQG+ SLQ L L++NNI + + ++L
Sbjct: 183 QLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFC 242
Query: 174 IEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVL---PSTLTEL 230
+E L+L +N P + F +L L LSL+ N + +P L L L
Sbjct: 243 LERLWLQRNAITHLPLSI--------FASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGL 294
Query: 231 YLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALT 290
L +N + + E F +L+ L+ L LS YNA +P F L
Sbjct: 295 SLTHNQLETVAEGTFAHLSNLRSLMLS------YNAI-----------THLPAGIFRDLE 337
Query: 291 ELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFL 326
EL L L SN+L + P F+N++KL+ L LS+N L
Sbjct: 338 ELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQL 373
Score = 60.5 bits (145), Expect = 8e-09
Identities = 96/420 (22%), Positives = 163/420 (38%), Gaps = 81/420 (19%)
Query: 128 YLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANI-EILYLG-QNCYY 185
+++ ++ +L +P +PP + + + ++ N+ ++++L Q C +
Sbjct: 29 FVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQF 88
Query: 186 RNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLT---ELYLYNNMIAKIQE 242
R DAF L +L+ L + ++ + T + S LT +L L NM+ + E
Sbjct: 89 R----------PDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPE 138
Query: 243 DDFNNLNQLQILDLSGN----CPRCYNAPFPCAPCKN---NSPLQIPVNAFDALTELKVL 295
F +L L+ L L GN PR P N N Q+P F LT L+ L
Sbjct: 139 GLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTL 198
Query: 296 RLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQV 355
+L +N+L +P F + LQEL L N +++ LP
Sbjct: 199 KLSNNALSGLPQGVFGKLGSLQELFLDSNNISE----------LP--------------- 233
Query: 356 YRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLS 415
Q FS L L+ L ++ L LS +L NL L L N +++
Sbjct: 234 -------PQVFSQLFCLERLWLQRNAITHLP---LSIFASLGNLTFLSLQWNMLRVLPAG 283
Query: 416 MFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSC 475
+F L + L+ N++ + + SN R+ + SY
Sbjct: 284 LFAHTPCLVGLSLTHNQLETVAEGT-FAHLSNLRSLMLSYN------------------- 323
Query: 476 RFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNG 535
+ A E K L L N++ + + FQ+LS L+ L+LS N ++ G
Sbjct: 324 AITHLPAGIFRDLEELVK----LYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEG 379
Score = 45.8 bits (107), Expect = 2e-04
Identities = 49/196 (25%), Positives = 79/196 (40%), Gaps = 29/196 (14%)
Query: 65 TNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPI--PLGSKNNMCIKRLQIKPRS 122
T+ L L+ N + + F +L L E+ N + P C++RL ++ +
Sbjct: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNA 252
Query: 123 --------FSGLTYLKSLYLDGNQLLEIPQGL---PPSLQLLSLEANNIFSIRKENLTEL 171
F+ L L L L N L +P GL P L LSL N + ++ + L
Sbjct: 253 ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312
Query: 172 ANIEILYLGQNCYYRNPCYVSYSIEK----------------DAFLNLTKLKVLSLKDNN 215
+N+ L L N P + +E+ F NL+KL++LSL N
Sbjct: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372
Query: 216 VTAVPTVLPSTLTELY 231
+T +P + T L+
Sbjct: 373 LTTLPEGIFDTNYNLF 388
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 107 bits (268), Expect = 4e-23
Identities = 114/402 (28%), Positives = 170/402 (42%), Gaps = 60/402 (14%)
Query: 50 DCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKN 109
DC++ L+ +PG + T L L++N++ ++ P FH L L E+ N +
Sbjct: 51 DCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS------- 103
Query: 110 NMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQLLSLEANNIFSIRKE 166
I ++FSGL LK L L NQL IP PSLQ L L+AN I + +
Sbjct: 104 -------HIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPER 156
Query: 167 NLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPST 226
+ L+++ L+L N P A NL L+ ++L N ++ +P
Sbjct: 157 SFEGLSSLRHLWLDDNALTEIPV--------RALNNLPALQAMTLALNRISHIPDYAFQN 208
Query: 227 LTE---LYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCA----------PC 273
LT L+L+NN I + F L+ L+ LDL+ N + FP A
Sbjct: 209 LTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ----EFPVAIRTLGRLQELGF 264
Query: 274 KNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDA 333
NN+ IP AF L+ + + N +Q V F+ + KL L L+ +E D
Sbjct: 265 HNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDL 324
Query: 334 KFLHFLPSLIQLDLSFNFELQVYRASMNL--SQAFSSLKSLKILRIRGYVFKELKSFNLS 391
K L++ L + RA + L S L L++L + +EL S
Sbjct: 325 K------GTTSLEI-----LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS---- 369
Query: 392 PLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKI 433
LH Q LE + L N I F Q L+ +DLS N I
Sbjct: 370 -LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAI 410
Score = 75.9 bits (185), Expect = 2e-13
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 39/270 (14%)
Query: 498 LDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL 557
LDLS N++ ++ F HL FL+ L LSGN +S + G F L L+ L NN+L +
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH-IPGQAFSGLYSLKILMLQNNQLGGI 129
Query: 558 HSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTME 617
+ A EL L+ L + +N E + L L+ L ++DN ++ R +
Sbjct: 130 PAEALWELPSLQSLRLDANLISLVPE------RSFEGLSSLRHLWLDDNALTEIPVRAL- 182
Query: 618 SESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNL 677
NL L+ + ++ N +S +P F + +L
Sbjct: 183 -----------------------------NNLPALQAMTLALNRISHIPDYAFQNL-TSL 212
Query: 678 KNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRS 737
L L N ++ + L NLETLDL++N+L P + R L+ L NN I++
Sbjct: 213 VVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGR-LQELGFHNNNIKA 271
Query: 738 LTKYFLQDAFQLRYLDLSSNKIQMIQKTSF 767
+ + L+ + N IQ + +++F
Sbjct: 272 IPEKAFMGNPLLQTIHFYDNPIQFVGRSAF 301
Score = 72.8 bits (177), Expect = 2e-12
Identities = 116/429 (27%), Positives = 185/429 (43%), Gaps = 37/429 (8%)
Query: 276 NSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKF 335
N+ ++ F L L+ LRL N L H+P + F + L+ L L N L +A
Sbjct: 76 NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEA-- 133
Query: 336 LHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHN 395
L LPSL L L N S+ ++F L SL+ L + E+ + L+N
Sbjct: 134 LWELPSLQSLRLDANL------ISLVPERSFEGLSSLRHLWLDDNALTEIP---VRALNN 184
Query: 396 LQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESY 455
L L+ + L N I F+ L V+ L N+I G S G N T +Y
Sbjct: 185 LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGL-HNLETLDLNY 243
Query: 456 EPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYG---QTLDLSKNSIFFVKSSD 512
++ E R + F N + ++ E + QT+ N I FV S
Sbjct: 244 N-KLQEFPVAIRTLGRLQELGFHNN--NIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA 300
Query: 513 FQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLD 572
FQ+L L L+L+G + Q + + L L + + LL S ++L +L VL+
Sbjct: 301 FQYLPKLHTLSLNGAMDIQEF--PDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLE 358
Query: 573 ISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLD 632
+S N Q E + + K L+++ + N I + T L +L+ LD
Sbjct: 359 LSHN----QIEELPSLHRCQK----LEEIGLQHNRIWEIGADTF--SQLSSLQ----ALD 404
Query: 633 VLWREGDNRYLQLFKNLLKLEELDISKNSLSFLP-SGVFDGMPPNLK-NLSLAKNGLKSF 690
+ W + + + F L L +LD++ N L+ LP +G+ M LK NL+L++ K
Sbjct: 405 LSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKD- 463
Query: 691 SWKKLQCLK 699
S+ KL+ L+
Sbjct: 464 SFPKLRILE 472
Score = 72.4 bits (176), Expect = 2e-12
Identities = 78/286 (27%), Positives = 132/286 (46%), Gaps = 22/286 (7%)
Query: 500 LSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHS 559
L N++ + +L L+ + L+ N IS + FQ L L L NNR+ L +
Sbjct: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISH-IPDYAFQNLTSLVVLHLHNNRIQHLGT 227
Query: 560 TAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRT-MES 618
+FE LH LE LD++ N + + L LQ+L ++N+I + + M +
Sbjct: 228 HSFEGLHNLETLDLNYNK-------LQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN 280
Query: 619 ESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLK 678
L+T+ F N + + R F+ L KL L ++ ++ G +L+
Sbjct: 281 PLLQTIHFYDNPIQFVGRSA-------FQYLPKLHTLSLN-GAMDIQEFPDLKG-TTSLE 331
Query: 679 NLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSL 738
L+L + G++ Q L L L+LSHNQ+ +P L C + L+ + L++N+I +
Sbjct: 332 ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS-LHRCQK-LEEIGLQHNRIWEI 389
Query: 739 TKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNR 784
L+ LDLS N I+ I +F + L++L L L N+
Sbjct: 390 GADTFSQLSSLQALDLSWNAIRSIHPEAF--STLHSLVKLDLTDNQ 433
Score = 61.2 bits (147), Expect = 5e-09
Identities = 60/221 (27%), Positives = 99/221 (44%), Gaps = 32/221 (14%)
Query: 571 LDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMES-ESLRTLEFRGN 629
LD+S N+ G+ H L F L++L ++ N +S + SL+ L + N
Sbjct: 71 LDLSMNNLTELQPGLFHHLRF------LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNN 124
Query: 630 HL-----DVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAK 684
L + LW L L+ L + N +S +P F+G+ +L++L L
Sbjct: 125 QLGGIPAEALWE------------LPSLQSLRLDANLISLVPERSFEGLS-SLRHLWLDD 171
Query: 685 NGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQ 744
N L + L L L+ + L+ N+++ +P+ SL L L NN+I+ L + +
Sbjct: 172 NALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE 231
Query: 745 DAFQLRYLDLSSNKIQMIQKTSFPENV--LNNLKMLLLHHN 783
L LDL+ NK+Q FP + L L+ L H+N
Sbjct: 232 GLHNLETLDLNYNKLQ-----EFPVAIRTLGRLQELGFHNN 267
Score = 57.8 bits (138), Expect = 5e-08
Identities = 49/163 (30%), Positives = 75/163 (46%), Gaps = 25/163 (15%)
Query: 645 LFKNLLKLEELDISKNSLSFLPSGVFDGMP-----------------------PNLKNLS 681
LF +L LEEL +S N LS +P F G+ P+L++L
Sbjct: 85 LFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLR 144
Query: 682 LAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKY 741
L N + + + L +L L L N LT +P R N +L+ + L N+I + Y
Sbjct: 145 LDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDY 204
Query: 742 FLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNR 784
Q+ L L L +N+IQ + SF L+NL+ L L++N+
Sbjct: 205 AFQNLTSLVVLHLHNNRIQHLGTHSF--EGLHNLETLDLNYNK 245
Score = 48.5 bits (114), Expect = 3e-05
Identities = 80/321 (24%), Positives = 116/321 (36%), Gaps = 79/321 (24%)
Query: 53 DKHLTEIPGGIPTNTTNL---TLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKN 109
D LTEIP N L TL +N I I +F L LV + N +
Sbjct: 171 DNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQ------- 223
Query: 110 NMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPP--SLQLLSLEANNIFSIRKE- 166
+ SF GL L++L L+ N+L E P + LQ L NNI +I ++
Sbjct: 224 -------HLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKA 276
Query: 167 -------NLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLN----------------- 202
+ I ++G++ + P + S+ +
Sbjct: 277 FMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLT 336
Query: 203 --------------LTKLKVLSLKDNNVTAVPTVLP-STLTELYLYNNMIAKIQEDDFNN 247
L +L+VL L N + +P++ L E+ L +N I +I D F+
Sbjct: 337 RAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQ 396
Query: 248 LNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPP 307
L+ LQ LDLS N R I AF L L L L N L +P
Sbjct: 397 LSSLQALDLSWNAIR-----------------SIHPEAFSTLHSLVKLDLTDNQLTTLPL 439
Query: 308 RWFKNINKLQ---ELDLSQNF 325
+ L+ L LSQ F
Sbjct: 440 AGLGGLMHLKLKGNLALSQAF 460
Score = 46.2 bits (108), Expect = 2e-04
Identities = 40/128 (31%), Positives = 62/128 (48%), Gaps = 6/128 (4%)
Query: 656 DISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVP 715
D S+ LS +P + P L L+ N L L+ LE L LS N L+ +P
Sbjct: 51 DCSELGLSAVPGD----LDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIP 106
Query: 716 ERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNL 775
+ + SLK L+L+NNQ+ + L + L+ L L +N I ++ + SF L++L
Sbjct: 107 GQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSF--EGLSSL 164
Query: 776 KMLLLHHN 783
+ L L N
Sbjct: 165 RHLWLDDN 172
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 106 bits (265), Expect = 1e-22
Identities = 134/504 (26%), Positives = 218/504 (43%), Gaps = 89/504 (17%)
Query: 339 LPSLI-QLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSF-NLSPLHNL 396
LPS + +LDLS N R S + + S L+SL+ +++ EL++ NL P+
Sbjct: 72 LPSWVARLDLSHN------RLSFIKASSMSHLQSLREVKLNN---NELETIPNLGPVS-- 120
Query: 397 QNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYE 456
N+ +L L N I K+F+ L+ +DLS N IS +++
Sbjct: 121 ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS----------------ELQTAF 164
Query: 457 PQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHL 516
P + QL Y Y S R + E + ++ L L++N I + F+ L
Sbjct: 165 PAL--QLKYL----YLNSNRVTSMEPGYF---DNLANTLLVLKLNRNRISAIPPKMFK-L 214
Query: 517 SFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN 576
L+ L L+ N I + ++G FQ L L+ L N + L AF L +E+L + N
Sbjct: 215 PQLQHLELNRNKI-KNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHN 273
Query: 577 SHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTME-SESLRTLEFRGNHLDVLW 635
+ ++G + L +LQ+L ++ N I+ + E + L L+ NHL
Sbjct: 274 NLTEITKGWLY------GLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLS--- 324
Query: 636 REGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKL 695
R D+ +L L L L I N +S++ F G
Sbjct: 325 RLDDSSFL----GLSLLNTLHIGNNRVSYIADCAFRG----------------------- 357
Query: 696 QCLKNLETLDLSHNQLTTVPERLSNCSRSL---KNLILKNNQIRSLTKYFLQDAFQLRYL 752
L +L+TLDL +N+++ E ++ L + LIL+ N+IRS+TK L +L
Sbjct: 358 --LSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHL 415
Query: 753 DLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDV 812
DLS N I +Q +F + + L+ L L+ + LC C W WV +
Sbjct: 416 DLSDNAIMSLQGNAFSQ--MKKLQQLHLNTSSLLCDCQLKWLPQWVAENNF---QSFVNA 470
Query: 813 TCVGPGAHKGQSV--ISLDLYTCE 834
+C P KG+S+ +S D + C+
Sbjct: 471 SCAHPQLLKGRSIFAVSPDGFVCD 494
Score = 90.1 bits (222), Expect = 1e-17
Identities = 101/395 (25%), Positives = 169/395 (42%), Gaps = 50/395 (12%)
Query: 195 IEKDAFLNLTKLKVLSLKDNNVTAVPTVLP--STLTELYLYNNMIAKIQEDDFNNLNQLQ 252
I+ + +L L+ + L +N + +P + P + +T L L N I +I + L+
Sbjct: 89 IKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLE 148
Query: 253 ILDLSGNCPRCYNAPFPCAPCK-----NNSPLQIPVNAFDALTE-LKVLRLHSNSLQHVP 306
LDLS N FP K +N + FD L L VL+L+ N + +P
Sbjct: 149 TLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIP 208
Query: 307 PRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAF 366
P+ FK + +LQ L+L++N + D L +L L + N ++ + AF
Sbjct: 209 PKMFK-LPQLQHLELNRNKIKNV--DGLTFQGLGALKSLKMQRNGVTKL------MDGAF 259
Query: 367 SSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVI 426
L +++IL++ L L+ L L+ L L N I + ++ ++L +
Sbjct: 260 WGLSNMEILQLD---HNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 316
Query: 427 DLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYD-KYARSCRFKNKEASFM 485
DL+ N +S DSS +G +L LH Y C F+ +
Sbjct: 317 DLTFNHLSRLDDSSFLGL-------------SLLNTLHIGNNRVSYIADCAFRGLSSL-- 361
Query: 486 SVNESCYKYGQTLDLSKNSIFFV---KSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLA 542
+TLDL N I + + F L L+ L L GN I +++ F L
Sbjct: 362 ----------KTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI-RSITKKAFTGLD 410
Query: 543 ELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNS 577
L +LD S+N + L AF ++ KL+ L ++++S
Sbjct: 411 ALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSS 445
Score = 84.0 bits (206), Expect = 7e-16
Identities = 111/435 (25%), Positives = 171/435 (39%), Gaps = 94/435 (21%)
Query: 48 IVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGS 107
++DC+ K L +P +P+ L L+ N + I +S L L E+ N
Sbjct: 57 LLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNN-------- 108
Query: 108 KNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEI-PQGLPP--SLQLLSLEANNIFSIR 164
L+ P + L L GN+++EI P+ L SL+ L L +NNI ++
Sbjct: 109 -------ELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ 161
Query: 165 KENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTK-LKVLSLKDNNVTAVPTV- 222
T +++ YL Y N V+ S+E F NL L VL L N ++A+P
Sbjct: 162 ----TAFPALQLKYL-----YLNSNRVT-SMEPGYFDNLANTLLVLKLNRNRISAIPPKM 211
Query: 223 --LPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQ 280
LP L L L N I + F L L+ L + + N +
Sbjct: 212 FKLPQ-LQHLELNRNKIKNVDGLTFQGLGALKSLKM-----------------QRNGVTK 253
Query: 281 IPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLP 340
+ AF L+ +++L+L N+L + W + LQEL LSQN + + DA F
Sbjct: 254 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDA--WEFCQ 311
Query: 341 SLIQLDLSFN------------------FELQVYRASMNLSQAFSSLKSLKIL------- 375
L +LDL+FN + R S AF L SLK L
Sbjct: 312 KLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEI 371
Query: 376 ---------------RIRGYVFK--ELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFK 418
++R + + ++S L LE LDL N I + F
Sbjct: 372 SWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFS 431
Query: 419 QFKRLKVIDLSVNKI 433
Q K+L+ + L+ + +
Sbjct: 432 QMKKLQQLHLNTSSL 446
Score = 52.4 bits (124), Expect = 2e-06
Identities = 43/130 (33%), Positives = 66/130 (50%), Gaps = 9/130 (6%)
Query: 655 LDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTV 714
LD S+ L+ LP + +P + L L+ N L + L++L + L++N+L T+
Sbjct: 58 LDCSRKRLARLP----EPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI 113
Query: 715 PERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNN 774
P L S ++ L L N+I + L++ L LDLSSN I +Q T+FP
Sbjct: 114 P-NLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ-TAFP---ALQ 168
Query: 775 LKMLLLHHNR 784
LK L L+ NR
Sbjct: 169 LKYLYLNSNR 178
>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 104 bits (259), Expect = 5e-22
Identities = 79/259 (30%), Positives = 115/259 (44%), Gaps = 37/259 (14%)
Query: 48 IVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGS 107
+V C+D L ++P +P +TT L L N I +I F L +L + N
Sbjct: 64 VVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNN-------- 115
Query: 108 KNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEN 167
K ++ P +F+ L L+ LYL NQL E+P+ +P +LQ L N I +RK
Sbjct: 116 ------KISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
Query: 168 LTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTL 227
L + ++ LG N S IE AF + KL + + D N+T++P LP +L
Sbjct: 170 FNGLNQMIVIELGTNPLK------SSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSL 223
Query: 228 TELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFD 287
TEL+L N I+++ LN L L LS N + N S P
Sbjct: 224 TELHLDGNKISRVDAASLKGLNNLAKLGLSFN---------SISAVDNGSLANTP----- 269
Query: 288 ALTELKVLRLHSNSLQHVP 306
L+ L L +N L VP
Sbjct: 270 ---HLRELHLDNNKLTRVP 285
Score = 60.8 bits (146), Expect = 6e-09
Identities = 67/276 (24%), Positives = 112/276 (40%), Gaps = 55/276 (19%)
Query: 498 LDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL 557
LDL N I +K DF++L L L L N IS+ G+ F PL +L L S N+L L
Sbjct: 86 LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGA-FTPLVKLERLYLSKNQLKEL 144
Query: 558 HSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTME 617
K K LQ+L ++N+I+
Sbjct: 145 PE---------------------------------KMPKTLQELRAHENEIT-------- 163
Query: 618 SESLRTLEFRGNHLDVLWREGDNRYLQ------LFKNLLKLEELDISKNSLSFLPSGVFD 671
+R + F G + ++ G N F+ + KL + I+ +++ +P
Sbjct: 164 --KVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIP----Q 217
Query: 672 GMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILK 731
G+PP+L L L N + L+ L NL L LS N ++ V + L+ L L
Sbjct: 218 GLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLD 277
Query: 732 NNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSF 767
NN++ + + + ++ + L +N I ++ + F
Sbjct: 278 NNKLTRVPGGLAEHKY-IQVVYLHNNNISVVGSSDF 312
Score = 58.2 bits (139), Expect = 4e-08
Identities = 84/335 (25%), Positives = 125/335 (37%), Gaps = 72/335 (21%)
Query: 179 LGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIA 238
LG C +R C+ L+V+ D + VP LP T L L NN I
Sbjct: 50 LGPVCPFRCQCH---------------LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKIT 94
Query: 239 KIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLH 298
+I++ DF NL L L L NN ++ AF L +L+ L L
Sbjct: 95 EIKDGDFKNLKNLHALIL-----------------VNNKISKVSPGAFTPLVKLERLYLS 137
Query: 299 SNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRA 358
N L+ +P + K LQEL +N + K + F + L +I ++L N ++
Sbjct: 138 KNQLKELPEKMPKT---LQELRAHENEITK-VRKVTF-NGLNQMIVIELGTN----PLKS 188
Query: 359 SMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFK 418
S + AF +K L +RI + L P +L L L N I + + K
Sbjct: 189 SGIENGAFQGMKKLSYIRIADTNITSIPQ-GLPP-----SLTELHLDGNKISRVDAASLK 242
Query: 419 QFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFK 478
L + LS N IS + S + R
Sbjct: 243 GLNNLAKLGLSFNSISAVDNGS-------------------------LANTPHLRELHLD 277
Query: 479 NKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDF 513
N + + + + +KY Q + L N+I V SSDF
Sbjct: 278 NNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDF 312
Score = 45.8 bits (107), Expect = 2e-04
Identities = 31/110 (28%), Positives = 51/110 (46%), Gaps = 16/110 (14%)
Query: 53 DKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMC 112
D ++T IP G+P + T L L N I + AS L++L ++ N +
Sbjct: 209 DTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISA--------- 259
Query: 113 IKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPS--LQLLSLEANNI 160
+ S + +L+ L+LD N+L +P GL +Q++ L NNI
Sbjct: 260 -----VDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNI 304
Score = 36.6 bits (83), Expect = 0.13
Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 5/111 (4%)
Query: 673 MPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKN 732
+PP+ L L N + + LKNL L L +N+++ V L+ L L
Sbjct: 79 LPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSK 138
Query: 733 NQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHN 783
NQ++ L + + +LR N+I ++K +F N LN + ++ L N
Sbjct: 139 NQLKELPEKMPKTLQELR---AHENEITKVRKVTF--NGLNQMIVIELGTN 184
>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 104 bits (259), Expect = 5e-22
Identities = 79/259 (30%), Positives = 115/259 (44%), Gaps = 37/259 (14%)
Query: 48 IVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGS 107
+V C+D L ++P +P +TT L L N I +I F L +L + N
Sbjct: 64 VVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNN-------- 115
Query: 108 KNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEN 167
K ++ P +F+ L L+ LYL NQL E+P+ +P +LQ L N I +RK
Sbjct: 116 ------KISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
Query: 168 LTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTL 227
L + ++ LG N S IE AF + KL + + D N+T++P LP +L
Sbjct: 170 FNGLNQMIVIELGTNPLK------SSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSL 223
Query: 228 TELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFD 287
TEL+L N I+++ LN L L LS N + N S P
Sbjct: 224 TELHLDGNKISRVDAASLKGLNNLAKLGLSFN---------SISAVDNGSLANTP----- 269
Query: 288 ALTELKVLRLHSNSLQHVP 306
L+ L L +N L VP
Sbjct: 270 ---HLRELHLDNNKLTRVP 285
Score = 60.8 bits (146), Expect = 6e-09
Identities = 67/276 (24%), Positives = 112/276 (40%), Gaps = 55/276 (19%)
Query: 498 LDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL 557
LDL N I +K DF++L L L L N IS+ G+ F PL +L L S N+L L
Sbjct: 86 LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGA-FTPLVKLERLYLSKNQLKEL 144
Query: 558 HSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTME 617
K K LQ+L ++N+I+
Sbjct: 145 PE---------------------------------KMPKTLQELRAHENEIT-------- 163
Query: 618 SESLRTLEFRGNHLDVLWREGDNRYLQ------LFKNLLKLEELDISKNSLSFLPSGVFD 671
+R + F G + ++ G N F+ + KL + I+ +++ +P
Sbjct: 164 --KVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIP----Q 217
Query: 672 GMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILK 731
G+PP+L L L N + L+ L NL L LS N ++ V + L+ L L
Sbjct: 218 GLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLD 277
Query: 732 NNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSF 767
NN++ + + + ++ + L +N I ++ + F
Sbjct: 278 NNKLTRVPGGLAEHKY-IQVVYLHNNNISVVGSSDF 312
Score = 58.2 bits (139), Expect = 4e-08
Identities = 84/335 (25%), Positives = 125/335 (37%), Gaps = 72/335 (21%)
Query: 179 LGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIA 238
LG C +R C+ L+V+ D + VP LP T L L NN I
Sbjct: 50 LGPVCPFRCQCH---------------LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKIT 94
Query: 239 KIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLH 298
+I++ DF NL L L L NN ++ AF L +L+ L L
Sbjct: 95 EIKDGDFKNLKNLHALIL-----------------VNNKISKVSPGAFTPLVKLERLYLS 137
Query: 299 SNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRA 358
N L+ +P + K LQEL +N + K + F + L +I ++L N ++
Sbjct: 138 KNQLKELPEKMPKT---LQELRAHENEITK-VRKVTF-NGLNQMIVIELGTN----PLKS 188
Query: 359 SMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFK 418
S + AF +K L +RI + L P +L L L N I + + K
Sbjct: 189 SGIENGAFQGMKKLSYIRIADTNITSIPQ-GLPP-----SLTELHLDGNKISRVDAASLK 242
Query: 419 QFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFK 478
L + LS N IS + S + R
Sbjct: 243 GLNNLAKLGLSFNSISAVDNGS-------------------------LANTPHLRELHLD 277
Query: 479 NKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDF 513
N + + + + +KY Q + L N+I V SSDF
Sbjct: 278 NNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDF 312
Score = 45.8 bits (107), Expect = 2e-04
Identities = 31/110 (28%), Positives = 51/110 (46%), Gaps = 16/110 (14%)
Query: 53 DKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMC 112
D ++T IP G+P + T L L N I + AS L++L ++ N +
Sbjct: 209 DTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISA--------- 259
Query: 113 IKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPS--LQLLSLEANNI 160
+ S + +L+ L+LD N+L +P GL +Q++ L NNI
Sbjct: 260 -----VDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNI 304
Score = 36.6 bits (83), Expect = 0.13
Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 5/111 (4%)
Query: 673 MPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKN 732
+PP+ L L N + + LKNL L L +N+++ V L+ L L
Sbjct: 79 LPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSK 138
Query: 733 NQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHN 783
NQ++ L + + +LR N+I ++K +F N LN + ++ L N
Sbjct: 139 NQLKELPEKMPKTLQELR---AHENEITKVRKVTF--NGLNQMIVIELGTN 184
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 103 bits (257), Expect = 8e-22
Identities = 106/398 (26%), Positives = 171/398 (42%), Gaps = 50/398 (12%)
Query: 49 VDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSK 108
VDC+ K LT +P G+ T L +++N+I + +F L E+ N +
Sbjct: 41 VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSF----- 95
Query: 109 NNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIP----QGLPPSLQLLSLEANNIFSIR 164
I P++ SGL LK L L NQL +P +GL +LQ L L+AN+I S+
Sbjct: 96 ---------IHPKALSGLKELKVLTLQNNQLKTVPSEAIRGL-SALQSLRLDANHITSVP 145
Query: 165 KENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVL- 223
+++ L + L+L N P + NL L+ L+L N ++++P
Sbjct: 146 EDSFEGLVQLRHLWLDDNSLTEVPVH--------PLSNLPTLQALTLALNKISSIPDFAF 197
Query: 224 --PSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPC------KN 275
S+L L+L+NN I + + F+ L+ L+ LDL+ N + P +
Sbjct: 198 TNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHS 257
Query: 276 NSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKF 335
NS IP AFD L+ + L+ N L V F N++ L L + + ++ +
Sbjct: 258 NSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPN--- 314
Query: 336 LHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHN 395
L + L+ ++ NL Q K L+ L + ++L SFN
Sbjct: 315 ---LTGTVHLESLTLTGTKISSIPNNLCQ---EQKMLRTLDLSYNNIRDLPSFN-----G 363
Query: 396 LQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKI 433
LE + L N I F+ L+++DLS N I
Sbjct: 364 CHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLI 401
Score = 89.7 bits (221), Expect = 1e-17
Identities = 116/450 (25%), Positives = 181/450 (40%), Gaps = 66/450 (14%)
Query: 136 GNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSI 195
G L +P+GL Q L + NNI + ++ +E L L N +S+ I
Sbjct: 45 GKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGND-------LSF-I 96
Query: 196 EKDAFLNLTKLKVLSLKDNNVTAVPTVLP---STLTELYLYNNMIAKIQEDDFNNLNQLQ 252
A L +LKVL+L++N + VP+ S L L L N I + ED F L QL+
Sbjct: 97 HPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLR 156
Query: 253 ILDLSGNCPRCYNAPFPCAPCKNNSPLQ-----------IPVNAFDALTELKVLRLHSNS 301
L L N P P N LQ IP AF L+ L VL LH+N
Sbjct: 157 HLWLDDNSL----TEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNK 212
Query: 302 LQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMN 361
++ + F ++ L+ LDL+ N L + + + LPSL +L N S+
Sbjct: 213 IRSLSQHCFDGLDNLETLDLNYNNLGE---FPQAIKALPSLKELGFHSN------SISVI 263
Query: 362 LSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFK 421
AF L+ + + L S HNL +L L I SM +QF
Sbjct: 264 PDGAFDGNPLLRTIHLYD---NPLSFVGNSAFHNLSDLHSL-------VIRGASMVQQFP 313
Query: 422 RLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKE 481
L + + ++ +G T + S + ++ K R+
Sbjct: 314 NL-TGTVHLESLTLTG------------TKISSIPNNLCQE------QKMLRTLDLSYNN 354
Query: 482 ASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPL 541
+ C+ + + L +N I+ +K FQ L L+ L+LS NLI + ++ F L
Sbjct: 355 IRDLPSFNGCHAL-EEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHE-IHSRAFATL 412
Query: 542 AELRYLDFSNNRLDLLHSTAFEELHKLEVL 571
+ LD S N L + L++L+++
Sbjct: 413 GPITNLDVSFNELTSFPTEGLNGLNQLKLV 442
Score = 81.6 bits (200), Expect = 3e-15
Identities = 110/431 (25%), Positives = 164/431 (38%), Gaps = 123/431 (28%)
Query: 486 SVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELR 545
+V E + Q LD+S N+I + F++ FL+ L L+GN +S ++ L EL+
Sbjct: 50 AVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLS-FIHPKALSGLKELK 108
Query: 546 YLDFSNNRLDLLHSTAFEELHKLEVLDISSN----------------------------- 576
L NN+L + S A L L+ L + +N
Sbjct: 109 VLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEV 168
Query: 577 -----SHYFQSEGITHMLN---------FTKNLKVLQKLMMNDNDISSSTSRTMES-ESL 621
S+ + +T LN FT NL L L +++N I S + + ++L
Sbjct: 169 PVHPLSNLPTLQALTLALNKISSIPDFAFT-NLSSLVVLHLHNNKIRSLSQHCFDGLDNL 227
Query: 622 RTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMP------- 674
TL+ N+L + Q K L L+EL NS+S +P G FDG P
Sbjct: 228 ETLDLNYNNL--------GEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHL 279
Query: 675 ---------------------------------PN------LKNLSLAKNGLKSFSWKKL 695
PN L++L+L + S
Sbjct: 280 YDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLC 339
Query: 696 QCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLS 755
Q K L TLDLS+N + +P N +L+ + L+ NQI + + Q LR LDLS
Sbjct: 340 QEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLS 397
Query: 756 SNKIQMI-------------------QKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVW 796
N I I + TSFP LN L L L N L +A+
Sbjct: 398 RNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKL--KEALAAKD 455
Query: 797 WVNHTEVTIPY 807
+VN +++PY
Sbjct: 456 FVNLRSLSVPY 466
Score = 38.5 bits (88), Expect = 0.033
Identities = 27/113 (23%), Positives = 54/113 (47%), Gaps = 4/113 (3%)
Query: 655 LDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTV 714
+D S L+ +P +G+ + L ++ N + + LE L L+ N L+ +
Sbjct: 41 VDCSGKGLTAVP----EGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFI 96
Query: 715 PERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSF 767
+ + + LK L L+NNQ++++ ++ L+ L L +N I + + SF
Sbjct: 97 HPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSF 149
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 103 bits (256), Expect = 1e-21
Identities = 130/496 (26%), Positives = 212/496 (42%), Gaps = 88/496 (17%)
Query: 346 DLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSF-NLSPLHNLQNLEVLDL 404
DLS N R S + + S L+SL+ +++ EL++ NL P+ N+ +L L
Sbjct: 20 DLSHN------RLSFIKASSMSHLQSLREVKLNN---NELETIPNLGPVS--ANITLLSL 68
Query: 405 GTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLH 464
N I K+F+ L+ +DLS N IS +++ P + QL
Sbjct: 69 AGNRIVEILPEHLKEFQSLETLDLSSNNIS----------------ELQTAFPAL--QLK 110
Query: 465 YFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNL 524
Y Y S R + E + ++ L L++N I + F+ L L+ L L
Sbjct: 111 YL----YLNSNRVTSMEPGYF---DNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLEL 162
Query: 525 SGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEG 584
+ N I + ++G FQ L L+ L N + L AF L +E+L + N+ ++G
Sbjct: 163 NRNKI-KNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKG 221
Query: 585 ITHMLNFTKNLKVLQKLMMNDNDISSSTSRTME-SESLRTLEFRGNHLDVLWREGDNRYL 643
+ L +LQ+L ++ N I+ + E + L L+ NHL R D+ +L
Sbjct: 222 WLY------GLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLS---RLDDSSFL 272
Query: 644 QLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLET 703
L L L I N +S++ F G L +L+T
Sbjct: 273 ----GLSLLNTLHIGNNRVSYIADCAFRG-------------------------LSSLKT 303
Query: 704 LDLSHNQLTTVPERLSNCSRSL---KNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQ 760
LDL +N+++ E ++ L + LIL+ N+IRS+TK L +LDLS N I
Sbjct: 304 LDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIM 363
Query: 761 MIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAH 820
+Q +F + + L+ L L+ + LC C W WV + +C P
Sbjct: 364 SLQGNAFSQ--MKKLQQLHLNTSSLLCDCQLKWLPQWVAENNF---QSFVNASCAHPQLL 418
Query: 821 KGQSV--ISLDLYTCE 834
KG+S+ +S D + C+
Sbjct: 419 KGRSIFAVSPDGFVCD 434
Score = 82.4 bits (202), Expect = 2e-15
Identities = 104/371 (28%), Positives = 152/371 (40%), Gaps = 68/371 (18%)
Query: 118 IKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPS--LQLLSLEANNIFSIRKENLTELANIE 175
IK S S L L+ + L+ N+L IP P S + LLSL N I I E+L E ++E
Sbjct: 29 IKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLE 88
Query: 176 ILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTV----LPSTLTELY 231
L L N + S + AF L +LK L L N VT++ L +TL L
Sbjct: 89 TLDLSSN---------NISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLK 138
Query: 232 LYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNA-------PFPCAPCKNNSPLQIPVN 284
L N I+ I F L QLQ L+L+ N + + + N ++
Sbjct: 139 LNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDG 197
Query: 285 AFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQ 344
AF L+ +++L+L N+L + W + LQEL LSQN + + DA F L +
Sbjct: 198 AFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDA--WEFCQKLSE 255
Query: 345 LDLSFN------------------FELQVYRASMNLSQAFSSLKSLKIL----------- 375
LDL+FN + R S AF L SLK L
Sbjct: 256 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 315
Query: 376 -----------RIRGYVFK--ELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKR 422
++R + + ++S L LE LDL N I + F Q K+
Sbjct: 316 EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 375
Query: 423 LKVIDLSVNKI 433
L+ + L+ + +
Sbjct: 376 LQQLHLNTSSL 386
Score = 66.6 bits (161), Expect = 1e-10
Identities = 74/302 (24%), Positives = 133/302 (44%), Gaps = 39/302 (12%)
Query: 49 VDCTDKHLTEIPGGIPT-NTTNLTLTINHIPDISPASFHRLDHLVEI----DFRCNCVP- 102
+D + +++E+ P L L N + + P F L + + + R + +P
Sbjct: 90 LDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPP 149
Query: 103 --IPLGSKNNMCIKRLQIKP---RSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQLLS 154
L ++ + R +IK +F GL LKSL + N + ++ G ++++L
Sbjct: 150 KMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQ 209
Query: 155 LEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDN 214
L+ NN+ I K L L ++ L+L QN R I DA+ KL L L N
Sbjct: 210 LDHNNLTEITKGWLYGLLMLQELHLSQNAINR--------ISPDAWEFCQKLSELDLTFN 261
Query: 215 NVTAVPT---VLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCA 271
+++ + + S L L++ NN ++ I + F L+ L+ LDL N
Sbjct: 262 HLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN------------ 309
Query: 272 PCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIG 331
+ + ++ AF L +L+ L L N ++ + + F ++ L+ LDLS N + G
Sbjct: 310 --EISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQG 367
Query: 332 DA 333
+A
Sbjct: 368 NA 369
>gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]
Length = 699
Score = 102 bits (253), Expect = 2e-21
Identities = 114/402 (28%), Positives = 177/402 (44%), Gaps = 41/402 (10%)
Query: 31 PKTLPCDVTLDVPK----NHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFH 86
P P TL +P ++ + C + LT+IP T+L LT N I I +F+
Sbjct: 305 PLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFN 364
Query: 87 RLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL 146
L +L +D SKNN I I P++F L L L +DGN L++IP L
Sbjct: 365 GLPNLERLDL----------SKNN--ITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQL 412
Query: 147 PPSLQLLSLEANNIFSIRKENLTELANIEILYL-GQNCYYRNPCYVSYSIEKDAFLNLTK 205
P +L+ L + NN+ +I +E+L++L + L L G N N + AF L
Sbjct: 413 PSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEAN-------VNPLAFKPLKS 465
Query: 206 LKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGN-CPRCY 264
L L L N +P LP ++ ELYL NN I +I E FN+ ++ ++ L N
Sbjct: 466 LAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENR 525
Query: 265 NAPFPCAPCKNNSPLQIPVNAFDAL-----TELKVLRLHSNSLQHVPPRWFKNINK-LQE 318
AP +N + + N + L L L N ++ +P F ++ L+
Sbjct: 526 IAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEY 585
Query: 319 LDLSQNFLAKEIGD-AKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRI 377
L LS N LA + D F SL +L L N +L+ ++ +K+L LR+
Sbjct: 586 LYLSFNKLADDGMDRVSFYGAYHSLRELFLDHN-DLK------SIPPGIQEMKALHFLRL 638
Query: 378 RGYVFKELKSFNL--SPLHNLQNLEVLDLGTNFIKIANLSMF 417
+ + + + + NLE L L N+IKI + +
Sbjct: 639 NNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSY 680
Score = 65.9 bits (159), Expect = 2e-10
Identities = 80/295 (27%), Positives = 129/295 (43%), Gaps = 57/295 (19%)
Query: 522 LNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDL--LHSTAFEELHKLEVLDISSNSHY 579
L L+GN I+ ++ F L L LD S N + + AF+ L KL L++ N+
Sbjct: 348 LELTGNSIA-SIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNN-- 404
Query: 580 FQSEGITHMLNFTKNL-KVLQKLMMNDNDISSSTSRTMES-ESLRTLEFRGNHLDVLWRE 637
++ L L++L +N+N++ + ++ L TLE GN+L
Sbjct: 405 --------LIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEA--- 453
Query: 638 GDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFS------ 691
N FK L L L + KN +P G +P +++ L L N ++ +
Sbjct: 454 --NVNPLAFKPLKSLAYLRLGKNKFRIIPQG----LPGSIEELYLENNQIEEITEICFNH 507
Query: 692 WKKLQCL--------------------KNLETLDLSHNQLTTVPERLSNCSRSLKNLILK 731
+K+ + +NLE++DLS+N+L VP L +SL +L+L
Sbjct: 508 TRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYL---PKSLLHLVLL 564
Query: 732 NNQIRSLTKY-FLQDAFQLRYLDLSSNKI--QMIQKTSFPENVLNNLKMLLLHHN 783
NQI + Y F L YL LS NK+ + + SF ++L+ L L HN
Sbjct: 565 GNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSF-YGAYHSLRELFLDHN 618
Score = 58.5 bits (140), Expect = 3e-08
Identities = 39/137 (28%), Positives = 70/137 (51%), Gaps = 6/137 (4%)
Query: 651 KLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKS--FSWKKLQCLKNLETLDLSH 708
++ L+++ NS++ +P F+G+ PNL+ L L+KN + S K + LK L L++
Sbjct: 344 QITSLELTGNSIASIPDEAFNGL-PNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDG 402
Query: 709 NQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFP 768
N L +P +L + +L+ L + N ++++ + L D QL L+L N +
Sbjct: 403 NNLIQIPSQLPS---TLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLA 459
Query: 769 ENVLNNLKMLLLHHNRF 785
L +L L L N+F
Sbjct: 460 FKPLKSLAYLRLGKNKF 476
Score = 47.0 bits (110), Expect = 9e-05
Identities = 62/245 (25%), Positives = 102/245 (41%), Gaps = 45/245 (18%)
Query: 543 ELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLM 602
++ L+ + N + + AF L LE LD+S N+ S GI K K+L+KLM
Sbjct: 344 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNN--ITSSGIG-----PKAFKLLKKLM 396
Query: 603 MNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLK-LEELDISKNS 661
+ D GN+L +Q+ L LEEL +++N+
Sbjct: 397 RLNMD--------------------GNNL-----------IQIPSQLPSTLEELKVNENN 425
Query: 662 LSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKL--QCLKNLETLDLSHNQLTTVPERLS 719
L + + L L L N L + L + LK+L L L N+ +P+ L
Sbjct: 426 LQAIDEESLSDLN-QLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLP 484
Query: 720 NCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLL 779
S++ L L+NNQI +T+ ++ + L NKI+ + NL+ +
Sbjct: 485 G---SIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESID 541
Query: 780 LHHNR 784
L +N+
Sbjct: 542 LSYNK 546
Score = 38.1 bits (87), Expect = 0.044
Identities = 62/285 (21%), Positives = 116/285 (40%), Gaps = 46/285 (16%)
Query: 496 QTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQT-LNGSEFQPLAELRYLDFSNNRL 554
+ L +++N++ + L+ L L L GN +S+ +N F+PL L YL N+
Sbjct: 417 EELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKF 476
Query: 555 DLLHST---AFEELH----KLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDND 607
++ + EEL+ ++E + +H + I N + ++ +N +
Sbjct: 477 RIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQEN 536
Query: 608 ISS---STSRTME-----SESLRTLEFRGNHLDVL------WREGDNRYLQLFKNLL--- 650
+ S S ++ +SL L GN ++ + E YL L N L
Sbjct: 537 LESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADD 596
Query: 651 ------------KLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCL 698
L EL + N L +P G+ + L L L N +++ +++
Sbjct: 597 GMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKA--LHFLRLNNNKIRNILPEEICNA 654
Query: 699 K-----NLETLDLSHN--QLTTVPERLSNCSRSLKNLILKNNQIR 736
+ NLE L L +N ++ +P +C RS +++LK I+
Sbjct: 655 EEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNIK 699
>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
sapiens]
Length = 674
Score = 100 bits (249), Expect = 7e-21
Identities = 90/318 (28%), Positives = 143/318 (44%), Gaps = 62/318 (19%)
Query: 18 IILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHI 77
I +++++ + P CD + + C D+ LT IP IP + T L L N I
Sbjct: 42 IAFLTEVIDSTTCPSVCRCD--------NGFIYCNDRGLTSIPADIPDDATTLYLQNNQI 93
Query: 78 PDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGN 137
+ +P L +K N+ + +YL N
Sbjct: 94 NNAG-------------------IPQDLKTKVNVQV------------------IYLYEN 116
Query: 138 QLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEK 197
L E P LP SL+ L L+ NN+ +I +++L + +E L+L N + SIE+
Sbjct: 117 DLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDN------SVSTVSIEE 170
Query: 198 DAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLS 257
DAF + +LK+L L N+++++P+ LP TL EL L +N I+ I F LN L+ L L
Sbjct: 171 DAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLD 230
Query: 258 GNC---PRCYNAPFPCAPCKNNSPLQIPVNAFDA------LTELKVLRLHSNSLQHVPPR 308
GN R + F + +N + L + N+ A L+ L L N++ H+P
Sbjct: 231 GNLLANQRIADDTF--SRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYN 288
Query: 309 WFKNINKLQELDLSQNFL 326
+ +L+ LDLS N L
Sbjct: 289 TLAKMRELERLDLSNNNL 306
Score = 71.6 bits (174), Expect = 4e-12
Identities = 68/247 (27%), Positives = 111/247 (44%), Gaps = 25/247 (10%)
Query: 595 LKVLQKLMMNDNDISSSTSRT---MESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLK 651
+ +L+KL ++DN +S+ + +S+ L+ L NHL + +
Sbjct: 150 IPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHT---------- 199
Query: 652 LEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKS--FSWKKLQCLKNLETLDLSHN 709
LEEL + N +S +P F G+ +L+ L L N L + + L+NL L L N
Sbjct: 200 LEELRLDDNRISTIPLHAFKGLN-SLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRN 258
Query: 710 QLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPE 769
L P L S L+ L L++N I + L +L LDLS+N + + + F +
Sbjct: 259 SLAAPPLNLP--SAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDD 316
Query: 770 NVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLD 829
L NL LLL +N + C C+ +W WV + + C GP +G ++ +
Sbjct: 317 --LGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVN--VRGLMCQGPEKVRGMAIKDI- 371
Query: 830 LYTCELD 836
T E+D
Sbjct: 372 --TSEMD 376
Score = 65.5 bits (158), Expect = 3e-10
Identities = 59/195 (30%), Positives = 92/195 (47%), Gaps = 18/195 (9%)
Query: 540 PLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQ 599
PL E +LD ++ + AF + +L++L +S N G+ H L+
Sbjct: 151 PLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPH---------TLE 201
Query: 600 KLMMNDNDISSSTSRTMES-ESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDIS 658
+L ++DN IS+ + SLR L GN L R D+ F L L EL +
Sbjct: 202 ELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLL-ANQRIADDT----FSRLQNLTELSLV 256
Query: 659 KNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERL 718
+NSL+ P + +L+ L L N + + L ++ LE LDLS+N LTT+P L
Sbjct: 257 RNSLAAPPLNLPSA---HLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGL 313
Query: 719 SNCSRSLKNLILKNN 733
+ +L L+L+NN
Sbjct: 314 FDDLGNLAQLLLRNN 328
Score = 55.8 bits (133), Expect = 2e-07
Identities = 80/309 (25%), Positives = 130/309 (42%), Gaps = 54/309 (17%)
Query: 132 LYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIR-KENLTELANIEILYLGQNCYYRNPCY 190
+Y + L IP +P L L+ N I + ++L N++++YL +N
Sbjct: 65 IYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNVQVIYLYEN-------- 116
Query: 191 VSYSIEKDAF-LNLTK-LKVLSLKDNNVTAVPT---VLPSTLTELYLYNNMIA--KIQED 243
+ D F +NL + L+ L L+DNNV + L +L+L +N ++ I+ED
Sbjct: 117 -----DLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEED 171
Query: 244 DFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQ 303
F + QL++L LS N ++ P +P L+ LRL N +
Sbjct: 172 AFADSKQLKLLFLSRNH-------------LSSIPSGLPHT-------LEELRLDDNRIS 211
Query: 304 HVPPRWFKNINKLQELDLSQNFLAKE-IGDAKFLHFLPSLIQLDLSFNFELQVYRASMNL 362
+P FK +N L+ L L N LA + I D F L +L +L L N + +NL
Sbjct: 212 TIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSR-LQNLTELSLVRN---SLAAPPLNL 267
Query: 363 SQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKR 422
A L+ L ++ + + L ++ LE LDL N + +F
Sbjct: 268 PSA-----HLQKLYLQDNAISHIP---YNTLAKMRELERLDLSNNNLTTLPRGLFDDLGN 319
Query: 423 LKVIDLSVN 431
L + L N
Sbjct: 320 LAQLLLRNN 328
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 99.4 bits (246), Expect = 2e-20
Identities = 185/831 (22%), Positives = 306/831 (36%), Gaps = 146/831 (17%)
Query: 49 VDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSK 108
VDC L +P IP NT L L N+I I+ F L HL + N
Sbjct: 39 VDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMEN--------- 89
Query: 109 NNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQLLSLEANNIFSIRK 165
K I+ +F L L+ L L+ N L P+ L L L L N I +I +
Sbjct: 90 -----KISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPR 144
Query: 166 ENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTV--- 222
+ +I+ L L N + C IE AF L L+VL+L +NN+T +
Sbjct: 145 KAFRGAVDIKNLQLDYN---QISC-----IEDGAFRALRDLEVLTLNNNNITRLSVASFN 196
Query: 223 -LPSTLTELYLYNNM-----------------------------------IAKIQEDDFN 246
+P T NN+ +A++Q+ +F
Sbjct: 197 HMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFV 256
Query: 247 NLNQLQILDLSGN---CPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQ 303
+ S + CP C+ +IP N + +TE+ RL N+++
Sbjct: 257 CSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEI---RLEQNTIK 313
Query: 304 HVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLS 363
+PP F KL+ +DLS N +++ DA L SL L L N ++ ++
Sbjct: 314 VIPPGAFSPYKKLRRIDLSNNQISELAPDA--FQGLRSLNSLVLYGNKITELPKS----- 366
Query: 364 QAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRL 423
F L SL++L + L+ LHNL L + D I S + + +
Sbjct: 367 -LFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTM 425
Query: 424 KVID---------------LSVNKISPSGD--SSEVGFCSNARTSVESYEPQVLEQLHYF 466
+ L N I SG +S + ++S + + + YF
Sbjct: 426 HLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYF 485
Query: 467 RYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSG 526
+ + ++ E C G T+D S + + Q+ + L+ N
Sbjct: 486 IPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEF 545
Query: 527 NLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGIT 586
++ T F+ L +LR ++FSNN++ + AFE + + ++SN + E +
Sbjct: 546 TVLEAT---GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSN----RLENVQ 598
Query: 587 HMLNFTKNLKVLQKLMMNDNDISS-STSRTMESESLRTLEFRGNHLDVLWREGDNRYLQL 645
H + K L+ L+ LM+ N I+ + S+R L N + +
Sbjct: 599 HKM--FKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGA------- 649
Query: 646 FKNLLKLEELDISKNSLS-----------FLPSGVFDGMPPNLKNLSLAKNGLKSFSWKK 694
F L L L++ N + + G P K L + ++ + +
Sbjct: 650 FDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQD 709
Query: 695 LQCLKNLETLDLSHNQLTTVP------ERLSNCS------------RSLKNLILKNNQIR 736
C + D S + L+ P + + CS R + L L NQ
Sbjct: 710 FTCDDGND--DNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFT 767
Query: 737 SLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLC 787
+ K L + L +DLS+N+I + SF + L L+L +NR C
Sbjct: 768 LVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSN--MTQLLTLILSYNRLRC 815
Score = 86.7 bits (213), Expect = 1e-16
Identities = 168/700 (24%), Positives = 265/700 (37%), Gaps = 114/700 (16%)
Query: 136 GNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSI 195
G L EIP LP ++ + LE N I I + + + L N +S +
Sbjct: 288 GKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNN-------QIS-EL 339
Query: 196 EKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLY---NNMIAKIQEDDFNNLNQLQ 252
DAF L L L L N +T +P L L L L N I ++ D F +L+ L
Sbjct: 340 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLN 399
Query: 253 ILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLR--LHSNSLQHVPPRWF 310
+L L N + A +P + + + N F LK L LH+N ++ R
Sbjct: 400 LLSLYDNKLQTI-AKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARC- 457
Query: 311 KNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLK 370
+ +L + Q K AK +F+P + YR+ ++ F+ L
Sbjct: 458 TSPRRLANKRIGQIKSKKFRCSAKEQYFIPGT-----------EDYRSKLS-GDCFADLA 505
Query: 371 SLKILRIRGYVFK-ELKSFNLSPLHNLQNLEVLDLGTN-FIKIANLSMFKQFKRLKVIDL 428
+ R G + N P H Q L L N F + +FK+ +L+
Sbjct: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLR---- 561
Query: 429 SVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASF---M 485
++ F +N T +E E +F
Sbjct: 562 ------------KINFSNNKITDIE---------------------------EGAFEGAS 582
Query: 486 SVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELR 545
VNE + L+ N + V+ F+ L LK L L N I+ N S F L+ +R
Sbjct: 583 GVNE--------ILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDS-FIGLSSVR 633
Query: 546 YLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMND 605
L +N++ + AF+ LH L L++ +N N L L + +
Sbjct: 634 LLSLYDNQITTVAPGAFDTLHSLSTLNLLANP-----------FNCNCYLAWLGEWLRKK 682
Query: 606 NDISSSTSRTMESESLRTLEFRGNHL-DVLWREG--DNRYLQLFKNLLKLEELDI----S 658
I + R + L+ + + + D +G DN L + + LD S
Sbjct: 683 R-IVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCS 741
Query: 659 KNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERL 718
L LP G+ P ++ L L N K+L K+L +DLS+N+++T+ +
Sbjct: 742 NKGLKVLPKGI----PRDVTELYLDGNQFTLVP-KELSNYKHLTLIDLSNNRISTLSNQS 796
Query: 719 SNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKML 778
+ L LIL N++R + LR L L N I ++ + +F N L+ L L
Sbjct: 797 FSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAF--NDLSALSHL 854
Query: 779 LLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPG 818
+ N C C+ W WV +E P +A C GPG
Sbjct: 855 AIGANPLYCDCNMQWLSDWVK-SEYKEPGIA---RCAGPG 890
Score = 84.7 bits (208), Expect = 4e-16
Identities = 142/615 (23%), Positives = 220/615 (35%), Gaps = 118/615 (19%)
Query: 48 IVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGS 107
IVDC K LTEIP +P T + L N I I P +F L ID N +
Sbjct: 283 IVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQIS----- 337
Query: 108 KNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPP---SLQLLSLEANNIFSIR 164
++ P +F GL L SL L GN++ E+P+ L SLQLL L AN I +R
Sbjct: 338 ---------ELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLR 388
Query: 165 KENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDN---------- 214
+ +L N+ +L L N +I K F L ++ + L N
Sbjct: 389 VDAFQDLHNLNLLSLYDN--------KLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKW 440
Query: 215 -----NVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQIL---------DLSGNC 260
+ + T + L N I +I+ F + Q LSG+C
Sbjct: 441 LADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDC 500
Query: 261 ---------PRCYNAPFPCAPCK-NNSPLQIP------------------VNAFDALTEL 292
RC C+ K N P IP F L +L
Sbjct: 501 FADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQL 560
Query: 293 KVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFE 352
+ + +N + + F+ + + E+ L+ N L E K L SL L L N
Sbjct: 561 RKINFSNNKITDIEEGAFEGASGVNEILLTSNRL--ENVQHKMFKGLESLKTLMLRSN-- 616
Query: 353 LQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLD--------- 403
R + + +F L S+++L + + LH+L L +L
Sbjct: 617 ----RITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYL 672
Query: 404 ------LGTNFIKIANLSMFKQF--KRLKVIDLSV-----------NKISPSGDSSEVGF 444
L I N K + K + + D+++ N SP
Sbjct: 673 AWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECT 732
Query: 445 CSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNS 504
C + + +VL + + + + + S YK+ +DLS N
Sbjct: 733 CLDTVVRCSNKGLKVLPK----GIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNR 788
Query: 505 IFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEE 564
I + + F +++ L L LS N + + + F L LR L N + ++ AF +
Sbjct: 789 ISTLSNQSFSNMTQLLTLILSYNRL-RCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFND 847
Query: 565 LHKLEVLDISSNSHY 579
L L L I +N Y
Sbjct: 848 LSALSHLAIGANPLY 862
Score = 65.1 bits (157), Expect = 3e-10
Identities = 50/195 (25%), Positives = 81/195 (41%), Gaps = 27/195 (13%)
Query: 653 EELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLT 712
E LD++ N+++ + F G+ +L+ L L +N + + Q LK LE L L+ N L
Sbjct: 58 ERLDLNGNNITRITKTDFAGLR-HLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQ 116
Query: 713 TVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPE--- 769
PE L + L L L NQI+++ + + A ++ L L N+I I+ +F
Sbjct: 117 LFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRD 176
Query: 770 -------------------NVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLAT 810
N + L+ LH N C C W W+ P +
Sbjct: 177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQR----PRVGL 232
Query: 811 DVTCVGPGAHKGQSV 825
C+GP +G +V
Sbjct: 233 YTQCMGPSHLRGHNV 247
Score = 47.4 bits (111), Expect = 7e-05
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 673 MPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKN 732
+P N + L L N + + L++L L L N+++T+ + L+ L L
Sbjct: 53 IPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNR 112
Query: 733 NQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAV 792
N ++ + +L LDLS N+IQ I + +F V ++K L L +N+ C D
Sbjct: 113 NHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAV--DIKNLQLDYNQISCIEDGA 170
Query: 793 W 793
+
Sbjct: 171 F 171
Score = 37.7 bits (86), Expect = 0.057
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 5/88 (5%)
Query: 696 QCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLS 755
QC + T+D L +VP N R+ + L L N I +TK LR L L
Sbjct: 31 QCSCSGSTVDCHGLALRSVPR---NIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLM 87
Query: 756 SNKIQMIQKTSFPENVLNNLKMLLLHHN 783
NKI I++ +F + L L+ L L+ N
Sbjct: 88 ENKISTIERGAFQD--LKELERLRLNRN 113
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 99.0 bits (245), Expect = 2e-20
Identities = 108/393 (27%), Positives = 176/393 (44%), Gaps = 64/393 (16%)
Query: 49 VDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVP-IPLGS 107
VDC+D L+E+P + T+ L L++N+I + P L L E+ N + IP G
Sbjct: 50 VDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKG- 108
Query: 108 KNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIP----QGLPPSLQLLSLEANNIFSI 163
+F+GL LK L L NQL +P Q L SLQ L L+AN+I +
Sbjct: 109 --------------AFTGLYSLKVLMLQNNQLRHVPTEALQNL-RSLQSLRLDANHISYV 153
Query: 164 RKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVL 223
+ L ++ L+L N P AF +L+ L+ ++L N + +P
Sbjct: 154 PPSCFSGLHSLRHLWLDDNALTEIPV--------QAFRSLSALQAMTLALNKIHHIPDYA 205
Query: 224 ---PSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQ 280
S+L L+L+NN I + + F+ L+ L+ LDL N + L
Sbjct: 206 FGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDL------------------NYNNLD 247
Query: 281 IPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLP 340
A L+ LK L HSN+++ +P + F L + N + + +G + F H LP
Sbjct: 248 EFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPI-QFVGRSAFQH-LP 305
Query: 341 SLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLE 400
L L L+ ++ + + +L+ L + G ++ S + + L NL+
Sbjct: 306 ELRTLTLNGASQITEF-------PDLTGTANLESLTLTG---AQISSLPQTVCNQLPNLQ 355
Query: 401 VLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKI 433
VLDL N ++ +L F ++L+ IDL N+I
Sbjct: 356 VLDLSYNLLE--DLPSFSVCQKLQKIDLRHNEI 386
Score = 85.1 bits (209), Expect = 3e-16
Identities = 124/464 (26%), Positives = 187/464 (40%), Gaps = 89/464 (19%)
Query: 213 DNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAP 272
D ++ +P+ L + L L N I+++ + +L L+ L L+GN
Sbjct: 54 DLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGN------------- 100
Query: 273 CKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGD 332
+ IP AF L LKVL L +N L+HVP +N+ LQ L L N ++ +
Sbjct: 101 ----ALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHIS-YVPP 155
Query: 333 AKF--LHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNL 390
+ F LH L L LD + E+ V QAF SL +L+ + + + +
Sbjct: 156 SCFSGLHSLRHL-WLDDNALTEIPV--------QAFRSLSALQAMTLALNKIHHIPDYAF 206
Query: 391 SPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNK-------ISPSGDSSEVG 443
NL +L VL L N I F L+ +DL+ N I + E+G
Sbjct: 207 G---NLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELG 263
Query: 444 FCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKN 503
F SN S+ E +F+ N S T+ N
Sbjct: 264 FHSNNIRSI---------------------------PEKAFVG-NPSLI----TIHFYDN 291
Query: 504 SIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFE 563
I FV S FQHL L+ L L+G SQ + A L L + ++ L T
Sbjct: 292 PIQFVGRSAFQHLPELRTLTLNG--ASQITEFPDLTGTANLESLTLTGAQISSLPQTVCN 349
Query: 564 ELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMES-ESLR 622
+L L+VLD+S N + + +F+ K LQK+ + N+I T + SLR
Sbjct: 350 QLPNLQVLDLSYNL-------LEDLPSFSVCQK-LQKIDLRHNEIYEIKVDTFQQLLSLR 401
Query: 623 TLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLP 666
+L N + ++ + F L L +LD+S N LS P
Sbjct: 402 SLNLAWNKIAII-------HPNAFSTLPSLIKLDLSSNLLSSFP 438
Score = 77.8 bits (190), Expect = 5e-14
Identities = 107/397 (26%), Positives = 178/397 (44%), Gaps = 50/397 (12%)
Query: 396 LQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKIS---PSGDSS-----EVGFCSN 447
L ++ DLG + + +NLS+F + +DLS+N IS P+ S E+ N
Sbjct: 47 LLRVDCSDLGLSELP-SNLSVFTSY-----LDLSMNNISQLLPNPLPSLRFLEELRLAGN 100
Query: 448 ARTSVES------YEPQVL----EQLHYFRYD--KYARSCRFKNKEASFMS-VNESCYKY 494
A T + Y +VL QL + + + RS + +A+ +S V SC+
Sbjct: 101 ALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSG 160
Query: 495 GQTLD---LSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSN 551
+L L N++ + F+ LS L+ + L+ N I + F L+ L L N
Sbjct: 161 LHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHH-IPDYAFGNLSSLVVLHLHN 219
Query: 552 NRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSS 611
NR+ L F+ LH LE LD++ N+ + + L L++L + N+I S
Sbjct: 220 NRIHSLGKKCFDGLHSLETLDLNYNN-------LDEFPTAIRTLSNLKELGFHSNNIRSI 272
Query: 612 TSRT-MESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVF 670
+ + + SL T+ F N + + R F++L +L L + N S +
Sbjct: 273 PEKAFVGNPSLITIHFYDNPIQFVGRSA-------FQHLPELRTLTL--NGASQITEFPD 323
Query: 671 DGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLIL 730
NL++L+L + S L NL+ LDLS+N L +P S C + L+ + L
Sbjct: 324 LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS-FSVCQK-LQKIDL 381
Query: 731 KNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSF 767
++N+I + Q LR L+L+ NKI +I +F
Sbjct: 382 RHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAF 418
Score = 61.2 bits (147), Expect = 5e-09
Identities = 65/240 (27%), Positives = 102/240 (42%), Gaps = 44/240 (18%)
Query: 546 YLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMND 605
YLD S N + L L LE L ++ N+ + +G FT L L+ LM+ +
Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGA-----FT-GLYSLKVLMLQN 123
Query: 606 NDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFL 665
N + R + +E+L+ NL L+ L + N +S++
Sbjct: 124 NQL-----RHVPTEALQ-------------------------NLRSLQSLRLDANHISYV 153
Query: 666 PSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSL 725
P F G+ +L++L L N L + + L L+ + L+ N++ +P+ SL
Sbjct: 154 PPSCFSGLH-SLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL 212
Query: 726 KNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENV--LNNLKMLLLHHN 783
L L NN+I SL K L LDL+ N + FP + L+NLK L H N
Sbjct: 213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLD-----EFPTAIRTLSNLKELGFHSN 267
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/132 (32%), Positives = 64/132 (48%), Gaps = 6/132 (4%)
Query: 652 LEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQL 711
L +D S LS LPS + L L+ N + L L+ LE L L+ N L
Sbjct: 47 LLRVDCSDLGLSELPSN----LSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNAL 102
Query: 712 TTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENV 771
T +P+ SLK L+L+NNQ+R + LQ+ L+ L L +N I + + F +
Sbjct: 103 TYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCF--SG 160
Query: 772 LNNLKMLLLHHN 783
L++L+ L L N
Sbjct: 161 LHSLRHLWLDDN 172
Score = 40.0 bits (92), Expect = 0.012
Identities = 60/233 (25%), Positives = 96/233 (41%), Gaps = 40/233 (17%)
Query: 49 VDCTDKHLTEIPGGIPT--NTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLG 106
+D +L E P I T N L N+I I +F L+ I F N PI
Sbjct: 239 LDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDN--PIQFV 296
Query: 107 SKNNMCIKRLQIKPRSFSGLTYLKSLYLDG-NQLLEIPQGL-PPSLQLLSLEANNIFSIR 164
++ +F L L++L L+G +Q+ E P +L+ L+L I S+
Sbjct: 297 GRS------------AFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLP 344
Query: 165 KENLTELANIEILYLGQNCYYRNPCYVS--------------YSIEKDAFLNLTKLKVLS 210
+ +L N+++L L N P + Y I+ D F L L+ L+
Sbjct: 345 QTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLN 404
Query: 211 LKDNNVTAVP----TVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGN 259
L N + + + LPS L +L L +N+++ L+ L L L+GN
Sbjct: 405 LAWNKIAIIHPNAFSTLPS-LIKLDLSSNLLSSF---PITGLHGLTHLKLTGN 453
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 97.8 bits (242), Expect = 5e-20
Identities = 123/438 (28%), Positives = 184/438 (42%), Gaps = 33/438 (7%)
Query: 365 AFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLK 424
AF +L SL L ++G +L S L L+NL L L N ++ L F L
Sbjct: 131 AFQNLSSLGFLNLQG---GQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 187
Query: 425 VIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASF 484
+ LS N++S D G S ++ VL + N+ A
Sbjct: 188 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 247
Query: 485 MSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAEL 544
S + LDLS+N++ +K++ F L L+ L L NLI+ G+ F L L
Sbjct: 248 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGA-FLGLKAL 306
Query: 545 RYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFT-KNLKVLQKLMM 603
R+LD S+NR+ L F L L VL +S N+ I + T K+L L++L +
Sbjct: 307 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA-------IASLRPRTFKDLHFLEELQL 359
Query: 604 NDNDISSSTSRTMES-ESLRTLEFRGNHLD--------------VLWREGD---NRYLQL 645
N I R+ E L L N L V+ G+ N Q+
Sbjct: 360 GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQV 419
Query: 646 FKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLD 705
F+ L KL L + + L + F G+ L+ L L NGL + L L L LD
Sbjct: 420 FRGLGKLHSLHLEGSCLGRIRPHTFTGLS-GLRRLFLKDNGLVGIEEQSLWGLAELLELD 478
Query: 706 LSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKT 765
L+ NQLT +P RL L+ L+L N++ L L + +LD+S N+++ + +
Sbjct: 479 LTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNS 538
Query: 766 SFPENVLNNLKMLLLHHN 783
L L+ L L +N
Sbjct: 539 LLAP--LGRLRYLSLRNN 554
Score = 95.5 bits (236), Expect = 2e-19
Identities = 137/551 (24%), Positives = 217/551 (39%), Gaps = 87/551 (15%)
Query: 36 CDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEID 95
C + D + + V C+ ++LT +P G+P T L L N++ + PA+F L L ++
Sbjct: 83 CVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLN 142
Query: 96 FRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQL 152
+ LGS ++P++ GL L L+L+ NQL + G P+L
Sbjct: 143 LQGG----QLGS----------LEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALAS 188
Query: 153 LSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKD-AFLNLTKLKVLSL 211
L L N + + L ++ L LG N S ++ D AF L
Sbjct: 189 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWN---------SLAVLPDAAFRGL-------- 231
Query: 212 KDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCA 271
+L EL L N +A +Q F+ L +L+ LDLS N R
Sbjct: 232 -------------GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRA-------- 270
Query: 272 PCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIG 331
I N F L L+ L L N + V P F + L+ LDLS N +A +
Sbjct: 271 ---------IKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLE 321
Query: 332 DAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAF--SSLKSLKILRIRGYVFKELKSFN 389
D P L+ L+V R S N + + K L L ++
Sbjct: 322 DT-----FPGLL--------GLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 368
Query: 390 LSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNAR 449
L LEVL L N ++ F + V++LS N + + E F +
Sbjct: 369 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR---NLPEQVFRGLGK 425
Query: 450 TSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNE-SCYKYGQTLDL--SKNSIF 506
E L ++ + + R K+ + + E S + + L+L + N +
Sbjct: 426 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 485
Query: 507 FVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELH 566
+ FQ L L+ L LS N +++ L PL +LD S+NRL+ L ++ L
Sbjct: 486 HLPHRLFQGLGKLEYLLLSRNRLAE-LPADALGPLQRAFWLDVSHNRLEALPNSLLAPLG 544
Query: 567 KLEVLDISSNS 577
+L L + +NS
Sbjct: 545 RLRYLSLRNNS 555
Score = 95.1 bits (235), Expect = 3e-19
Identities = 141/552 (25%), Positives = 220/552 (39%), Gaps = 75/552 (13%)
Query: 189 CYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNL 248
C SY + D +L V N+T +P +P L+L N ++ + F NL
Sbjct: 83 CVCSYDDDAD------ELSVFC-SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNL 135
Query: 249 NQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPR 308
+ L L+L G + A L L L L N L+ +
Sbjct: 136 SSLGFLNLQGG-----------------QLGSLEPQALLGLENLCHLHLERNQLRSLALG 178
Query: 309 WFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSS 368
F + L L LS N L++ + D F L SL L+L +N ++ AF
Sbjct: 179 TFAHTPALASLGLSNNRLSR-LEDGLF-EGLGSLWDLNLGWN------SLAVLPDAAFRG 230
Query: 369 LKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDL 428
L SL+ L + G L+ S L L+ L DL N ++ ++F Q RL+ + L
Sbjct: 231 LGSLRELVLAGNRLAYLQPALFSGLAELREL---DLSRNALRAIKANVFVQLPRLQKLYL 287
Query: 429 SVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVN 488
N I+ + +G L+ L + N+ A +
Sbjct: 288 DRNLIAAVAPGAFLG----------------LKALRWLDLSH--------NRVAGLLEDT 323
Query: 489 ESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLD 548
+ L LS N+I ++ F+ L FL+ L L N I Q S F+ L +L L
Sbjct: 324 FPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERS-FEGLGQLEVLT 382
Query: 549 FSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDI 608
+N+L + + AF L + V+++S N E + + L L L + + +
Sbjct: 383 LDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVF------RGLGKLHSLHLEGSCL 436
Query: 609 SSSTSRTMESES-LRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPS 667
T S LR L + N L + Q L +L ELD++ N L+ LP
Sbjct: 437 GRIRPHTFTGLSGLRRLFLKDNGLVGIEE-------QSLWGLAELLELDLTSNQLTHLPH 489
Query: 668 GVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKN 727
+F G+ L+ L L++N L L L+ LD+SHN+L +P L L+
Sbjct: 490 RLFQGLG-KLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRY 548
Query: 728 LILKNNQIRSLT 739
L L+NN +R+ T
Sbjct: 549 LSLRNNSLRTFT 560
Score = 84.0 bits (206), Expect = 7e-16
Identities = 89/292 (30%), Positives = 130/292 (44%), Gaps = 22/292 (7%)
Query: 496 QTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLD 555
Q L L N++ V + FQ+LS L LNL G + +L L L +L N+L
Sbjct: 115 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLG-SLEPQALLGLENLCHLHLERNQLR 173
Query: 556 LLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRT 615
L F L L +S+N +G+ + L L L + N ++
Sbjct: 174 SLALGTFAHTPALASLGLSNNRLSRLEDGL------FEGLGSLWDLNLGWNSLAVLPDAA 227
Query: 616 MES-ESLRTLEFRGNHLDVLWREGDNRYLQ--LFKNLLKLEELDISKNSLSFLPSGVFDG 672
SLR L GN L YLQ LF L +L ELD+S+N+L + + VF
Sbjct: 228 FRGLGSLRELVLAGNRL---------AYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 278
Query: 673 MPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKN 732
+ P L+ L L +N + + + LK L LDLSHN++ + E L+ L L +
Sbjct: 279 L-PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 337
Query: 733 NQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNR 784
N I SL +D L L L N+I+ + + SF L L++L L HN+
Sbjct: 338 NAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSF--EGLGQLEVLTLDHNQ 387
Score = 37.7 bits (86), Expect = 0.057
Identities = 35/117 (29%), Positives = 55/117 (47%), Gaps = 6/117 (5%)
Query: 653 EELDI--SKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQ 710
+EL + S +L+ LP DG+P + L L N L S Q L +L L+L Q
Sbjct: 92 DELSVFCSSRNLTRLP----DGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQ 147
Query: 711 LTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSF 767
L ++ + +L +L L+ NQ+RSL L L LS+N++ ++ F
Sbjct: 148 LGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLF 204
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 97.8 bits (242), Expect = 5e-20
Identities = 123/438 (28%), Positives = 184/438 (42%), Gaps = 33/438 (7%)
Query: 365 AFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLK 424
AF +L SL L ++G +L S L L+NL L L N ++ L F L
Sbjct: 93 AFQNLSSLGFLNLQG---GQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 149
Query: 425 VIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASF 484
+ LS N++S D G S ++ VL + N+ A
Sbjct: 150 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 209
Query: 485 MSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAEL 544
S + LDLS+N++ +K++ F L L+ L L NLI+ G+ F L L
Sbjct: 210 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGA-FLGLKAL 268
Query: 545 RYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFT-KNLKVLQKLMM 603
R+LD S+NR+ L F L L VL +S N+ I + T K+L L++L +
Sbjct: 269 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA-------IASLRPRTFKDLHFLEELQL 321
Query: 604 NDNDISSSTSRTMES-ESLRTLEFRGNHLD--------------VLWREGD---NRYLQL 645
N I R+ E L L N L V+ G+ N Q+
Sbjct: 322 GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQV 381
Query: 646 FKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLD 705
F+ L KL L + + L + F G+ L+ L L NGL + L L L LD
Sbjct: 382 FRGLGKLHSLHLEGSCLGRIRPHTFTGLS-GLRRLFLKDNGLVGIEEQSLWGLAELLELD 440
Query: 706 LSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKT 765
L+ NQLT +P RL L+ L+L N++ L L + +LD+S N+++ + +
Sbjct: 441 LTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNS 500
Query: 766 SFPENVLNNLKMLLLHHN 783
L L+ L L +N
Sbjct: 501 LLAP--LGRLRYLSLRNN 516
Score = 95.5 bits (236), Expect = 2e-19
Identities = 137/551 (24%), Positives = 217/551 (39%), Gaps = 87/551 (15%)
Query: 36 CDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEID 95
C + D + + V C+ ++LT +P G+P T L L N++ + PA+F L L ++
Sbjct: 45 CVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLN 104
Query: 96 FRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQL 152
+ LGS ++P++ GL L L+L+ NQL + G P+L
Sbjct: 105 LQGG----QLGS----------LEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALAS 150
Query: 153 LSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKD-AFLNLTKLKVLSL 211
L L N + + L ++ L LG N S ++ D AF L
Sbjct: 151 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWN---------SLAVLPDAAFRGL-------- 193
Query: 212 KDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCA 271
+L EL L N +A +Q F+ L +L+ LDLS N R
Sbjct: 194 -------------GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRA-------- 232
Query: 272 PCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIG 331
I N F L L+ L L N + V P F + L+ LDLS N +A +
Sbjct: 233 ---------IKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLE 283
Query: 332 DAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAF--SSLKSLKILRIRGYVFKELKSFN 389
D P L+ L+V R S N + + K L L ++
Sbjct: 284 DT-----FPGLL--------GLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 330
Query: 390 LSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNAR 449
L LEVL L N ++ F + V++LS N + + E F +
Sbjct: 331 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR---NLPEQVFRGLGK 387
Query: 450 TSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNE-SCYKYGQTLDL--SKNSIF 506
E L ++ + + R K+ + + E S + + L+L + N +
Sbjct: 388 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 447
Query: 507 FVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELH 566
+ FQ L L+ L LS N +++ L PL +LD S+NRL+ L ++ L
Sbjct: 448 HLPHRLFQGLGKLEYLLLSRNRLAE-LPADALGPLQRAFWLDVSHNRLEALPNSLLAPLG 506
Query: 567 KLEVLDISSNS 577
+L L + +NS
Sbjct: 507 RLRYLSLRNNS 517
Score = 95.1 bits (235), Expect = 3e-19
Identities = 141/552 (25%), Positives = 220/552 (39%), Gaps = 75/552 (13%)
Query: 189 CYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNL 248
C SY + D +L V N+T +P +P L+L N ++ + F NL
Sbjct: 45 CVCSYDDDAD------ELSVFC-SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNL 97
Query: 249 NQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPR 308
+ L L+L G + A L L L L N L+ +
Sbjct: 98 SSLGFLNLQGG-----------------QLGSLEPQALLGLENLCHLHLERNQLRSLALG 140
Query: 309 WFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSS 368
F + L L LS N L++ + D F L SL L+L +N ++ AF
Sbjct: 141 TFAHTPALASLGLSNNRLSR-LEDGLF-EGLGSLWDLNLGWN------SLAVLPDAAFRG 192
Query: 369 LKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDL 428
L SL+ L + G L+ S L L+ L DL N ++ ++F Q RL+ + L
Sbjct: 193 LGSLRELVLAGNRLAYLQPALFSGLAELREL---DLSRNALRAIKANVFVQLPRLQKLYL 249
Query: 429 SVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVN 488
N I+ + +G L+ L + N+ A +
Sbjct: 250 DRNLIAAVAPGAFLG----------------LKALRWLDLSH--------NRVAGLLEDT 285
Query: 489 ESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLD 548
+ L LS N+I ++ F+ L FL+ L L N I Q S F+ L +L L
Sbjct: 286 FPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERS-FEGLGQLEVLT 344
Query: 549 FSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDI 608
+N+L + + AF L + V+++S N E + + L L L + + +
Sbjct: 345 LDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVF------RGLGKLHSLHLEGSCL 398
Query: 609 SSSTSRTMESES-LRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPS 667
T S LR L + N L + Q L +L ELD++ N L+ LP
Sbjct: 399 GRIRPHTFTGLSGLRRLFLKDNGLVGIEE-------QSLWGLAELLELDLTSNQLTHLPH 451
Query: 668 GVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKN 727
+F G+ L+ L L++N L L L+ LD+SHN+L +P L L+
Sbjct: 452 RLFQGLG-KLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRY 510
Query: 728 LILKNNQIRSLT 739
L L+NN +R+ T
Sbjct: 511 LSLRNNSLRTFT 522
Score = 84.0 bits (206), Expect = 7e-16
Identities = 89/292 (30%), Positives = 130/292 (44%), Gaps = 22/292 (7%)
Query: 496 QTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLD 555
Q L L N++ V + FQ+LS L LNL G + +L L L +L N+L
Sbjct: 77 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLG-SLEPQALLGLENLCHLHLERNQLR 135
Query: 556 LLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRT 615
L F L L +S+N +G+ + L L L + N ++
Sbjct: 136 SLALGTFAHTPALASLGLSNNRLSRLEDGL------FEGLGSLWDLNLGWNSLAVLPDAA 189
Query: 616 MES-ESLRTLEFRGNHLDVLWREGDNRYLQ--LFKNLLKLEELDISKNSLSFLPSGVFDG 672
SLR L GN L YLQ LF L +L ELD+S+N+L + + VF
Sbjct: 190 FRGLGSLRELVLAGNRL---------AYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 240
Query: 673 MPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKN 732
+ P L+ L L +N + + + LK L LDLSHN++ + E L+ L L +
Sbjct: 241 L-PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 299
Query: 733 NQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNR 784
N I SL +D L L L N+I+ + + SF L L++L L HN+
Sbjct: 300 NAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSF--EGLGQLEVLTLDHNQ 349
Score = 37.7 bits (86), Expect = 0.057
Identities = 35/117 (29%), Positives = 55/117 (47%), Gaps = 6/117 (5%)
Query: 653 EELDI--SKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQ 710
+EL + S +L+ LP DG+P + L L N L S Q L +L L+L Q
Sbjct: 54 DELSVFCSSRNLTRLP----DGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQ 109
Query: 711 LTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSF 767
L ++ + +L +L L+ NQ+RSL L L LS+N++ ++ F
Sbjct: 110 LGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLF 166
>gi|41350214 asporin [Homo sapiens]
Length = 380
Score = 97.4 bits (241), Expect = 6e-20
Identities = 81/265 (30%), Positives = 118/265 (44%), Gaps = 29/265 (10%)
Query: 48 IVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGS 107
+V C+D LT +P IP +T L L N I +I F L L + N
Sbjct: 85 VVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNN-------- 136
Query: 108 KNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEN 167
K +I P++F L+ LYL NQL EIP LP SL L + N + I+K+
Sbjct: 137 ------KLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDT 190
Query: 168 LTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTL 227
+ + +L + N N IE AF +T + + + +T+VP LP TL
Sbjct: 191 FKGMNALHVLEMSANPLDNN------GIEPGAFEGVTVFHI-RIAEAKLTSVPKGLPPTL 243
Query: 228 TELYLYNNMIAKIQEDDFNNLNQLQILDLSGN-CPRCYNAPFPCAP------CKNNSPLQ 280
EL+L N I+ ++ +DF +LQ L L N N P +NN +
Sbjct: 244 LELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKK 303
Query: 281 IPVNAFDALTELKVLRLHSNSLQHV 305
IP + L L+++ LHSNS+ V
Sbjct: 304 IP-SGLPELKYLQIIFLHSNSIARV 327
Score = 70.5 bits (171), Expect = 8e-12
Identities = 57/217 (26%), Positives = 89/217 (41%), Gaps = 43/217 (19%)
Query: 128 YLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRN 187
Y + ++ L +P +P ++L L+ N I I++ + L ++ L L N +
Sbjct: 82 YSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTK- 140
Query: 188 PCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNN 247
I AFL KL+ L L N ++ +P LP +L EL ++ N + KIQ+D F
Sbjct: 141 -------IHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKG 193
Query: 248 LNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKV------------- 294
+N L +L++S N P NN I AF+ +T +
Sbjct: 194 MNALHVLEMSAN------------PLDNNG---IEPGAFEGVTVFHIRIAEAKLTSVPKG 238
Query: 295 -------LRLHSNSLQHVPPRWFKNINKLQELDLSQN 324
L L N + V FK +LQ L L N
Sbjct: 239 LPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNN 275
Score = 55.1 bits (131), Expect = 3e-07
Identities = 67/263 (25%), Positives = 116/263 (44%), Gaps = 28/263 (10%)
Query: 520 KCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHY 579
+ L+L N I + + ++F+ L L L +NN+L +H AF KL L +S N
Sbjct: 105 RMLDLQNNKIKE-IKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQ-- 161
Query: 580 FQSEGITHMLNFTKNL-KVLQKLMMNDNDISSSTSRTMES-ESLRTLEFRGNHLDVLWRE 637
+ NL K L +L +++N + T + +L LE N LD E
Sbjct: 162 --------LSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIE 213
Query: 638 -GDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQ 696
G + +F + I++ L+ +P G +PP L L L N + + + +
Sbjct: 214 PGAFEGVTVF-------HIRIAEAKLTSVPKG----LPPTLLELHLDYNKISTVELEDFK 262
Query: 697 CLKNLETLDLSHNQLTTVPE-RLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLS 755
K L+ L L +N++T + L+N R ++ + L+NN+++ + L + L+ + L
Sbjct: 263 RYKELQRLGLGNNKITDIENGSLANIPR-VREIHLENNKLKKIPS-GLPELKYLQIIFLH 320
Query: 756 SNKIQMIQKTSFPENVLNNLKML 778
SN I + F V K L
Sbjct: 321 SNSIARVGVNDFCPTVPKMKKSL 343
Score = 50.1 bits (118), Expect = 1e-05
Identities = 78/327 (23%), Positives = 121/327 (37%), Gaps = 77/327 (23%)
Query: 255 DLSGNCP---RCYNAPFPCAPCKNNS-PLQIPVNAFDALTELKVLRLHSNSLQHVPPRWF 310
DL CP +CY+ C+ S P IP FD ++L L +N ++ + F
Sbjct: 70 DLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIP---FDT----RMLDLQNNKIKEIKENDF 122
Query: 311 KNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLK 370
K + L L L+ N L K +H +AF + K
Sbjct: 123 KGLTSLYGLILNNNKLTK-------IH-------------------------PKAFLTTK 150
Query: 371 SLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSV 430
L+ L + E+ PL+ ++L L + N +K FK L V+++S
Sbjct: 151 KLRRLYLSHNQLSEI------PLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSA 204
Query: 431 NKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNES 490
N + +G EP E + F + EA SV +
Sbjct: 205 NPLDNNG-----------------IEPGAFEGVTVFH---------IRIAEAKLTSVPKG 238
Query: 491 CYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFS 550
L L N I V+ DF+ L+ L L N I+ NGS + +R +
Sbjct: 239 LPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGS-LANIPRVREIHLE 297
Query: 551 NNRLDLLHSTAFEELHKLEVLDISSNS 577
NN+L + S EL L+++ + SNS
Sbjct: 298 NNKLKKIPS-GLPELKYLQIIFLHSNS 323
Score = 40.4 bits (93), Expect = 0.009
Identities = 29/106 (27%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 673 MPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKN 732
+P + + L L N +K + L +L L L++N+LT + + ++ L+ L L +
Sbjct: 100 IPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSH 159
Query: 733 NQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFP-ENVLNNLKM 777
NQ+ + + +LR + NK++ IQK +F N L+ L+M
Sbjct: 160 NQLSEIPLNLPKSLAELR---IHENKVKKIQKDTFKGMNALHVLEM 202
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 97.1 bits (240), Expect = 8e-20
Identities = 117/447 (26%), Positives = 187/447 (41%), Gaps = 67/447 (14%)
Query: 426 IDLSVNKIS---PSG-----DSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRF 477
++LS NK+S P+G + EV +N T+V S + F RS
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEG 132
Query: 478 KNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSE 537
+A Y + LDLS N+I V+++ F H +K LNL+GN I TL
Sbjct: 133 SQLKA---------YLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIG-TLELGA 182
Query: 538 FQPLA------------------------ELRYLDFSNNRLDLLHSTAFEELHKLEVLDI 573
F L+ L LD + NR+ L+ F+ L+ LEVL +
Sbjct: 183 FDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKL 242
Query: 574 SSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMES-ESLRTLEFRGNHLD 632
N+ ++G L + L + N + S ++ +L L N +
Sbjct: 243 QRNNISKLTDGAFW------GLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIA 296
Query: 633 VLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSW 692
+ R+G + KL EL +S N+L+ L + +L L L+ N + +
Sbjct: 297 RIHRKG-------WSFCQKLHELVLSFNNLTRLDEESLAEL-SSLSVLRLSHNSISHIAE 348
Query: 693 KKLQCLKNLETLDLSHNQLTTVPERLSNCSR---SLKNLILKNNQIRSLTKYFLQDAFQL 749
+ L++L LDL HN+++ E S SL L L N+I+S+ K L
Sbjct: 349 GAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGL 408
Query: 750 RYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLA 809
+L+L N I+ +Q +F + + NLK L + + FLC C W W+ + A
Sbjct: 409 EHLNLGGNAIRSVQFDAFVK--MKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTA 466
Query: 810 TDVTCVGPGAHKGQSVISL--DLYTCE 834
TC P + KGQS+ S+ + + C+
Sbjct: 467 ---TCAHPESLKGQSIFSVPPESFVCD 490
Score = 93.2 bits (230), Expect = 1e-18
Identities = 113/417 (27%), Positives = 172/417 (41%), Gaps = 66/417 (15%)
Query: 49 VDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSK 108
+DC + L +PG +P+ T +L L+ N + +I PA F L +L E+ N
Sbjct: 52 LDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNN--------- 102
Query: 109 NNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPP---SLQLLSLEANNIFSIRK 165
L P + +++ SL+L N++ + SL++L L NNI +R
Sbjct: 103 ------ELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRN 156
Query: 166 ENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTK-LKVLSLKDNNVTAVPT--- 221
I+ L L N ++E AF L++ L L L N +T +P
Sbjct: 157 TCFPHGPPIKELNLAGNRI--------GTLELGAFDGLSRSLLTLRLSKNRITQLPVRAF 208
Query: 222 VLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLS-GNCPRCYNAPF------PCAPCK 274
LP LT+L L N I I+ F LN L++L L N + + F +
Sbjct: 209 KLP-RLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLE 267
Query: 275 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAK------ 328
NS +++ + LT L L L +NS+ + + + KL EL LS N L +
Sbjct: 268 YNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESL 327
Query: 329 -EIGDAKFLHF---------------LPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSL 372
E+ L L SL LDL N ++ + S AFS L SL
Sbjct: 328 AELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHN---EISGTIEDTSGAFSGLDSL 384
Query: 373 KILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLS 429
L + G ++KS L+ LE L+LG N I+ F + K LK + +S
Sbjct: 385 SKLTLFG---NKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHIS 438
Score = 54.7 bits (130), Expect = 5e-07
Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 5/116 (4%)
Query: 653 EELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLT 712
+ LD L+ LP +P ++L+L+ N L + L NL+ + L++N+LT
Sbjct: 50 DSLDCGGRGLAALPGD----LPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELT 105
Query: 713 TVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFP 768
VP L S + +L L++N+IRS+ L+ L LDLS N I ++ T FP
Sbjct: 106 AVPS-LGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFP 160
Score = 50.4 bits (119), Expect = 9e-06
Identities = 62/240 (25%), Positives = 102/240 (42%), Gaps = 42/240 (17%)
Query: 545 RYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMN 604
R L+ S N+L + FE+L LQ++ +N
Sbjct: 71 RSLNLSYNKLSEIDPAGFEDLPN------------------------------LQEVYLN 100
Query: 605 DNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSF 664
+N++++ S S + +L + N + + EG K L LE LD+S N+++
Sbjct: 101 NNELTAVPSLGAASSHVVSLFLQHNKIRSV--EGSQ-----LKAYLSLEVLDLSLNNITE 153
Query: 665 LPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCL-KNLETLDLSHNQLTTVPERLSNCSR 723
+ + F PP +K L+LA N + + L ++L TL LS N++T +P R R
Sbjct: 154 VRNTCFPHGPP-IKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPR 212
Query: 724 SLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHN 783
L L L N+IR + Q L L L N I + +F L+ + +L L +N
Sbjct: 213 -LTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWG--LSKMHVLHLEYN 269
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 95.9 bits (237), Expect = 2e-19
Identities = 90/318 (28%), Positives = 125/318 (39%), Gaps = 84/318 (26%)
Query: 32 KTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDIS-PASFHRLDH 90
K L C +N V C ++ LT +P GIP T L L N I + PA H +
Sbjct: 32 KLLACPSVCRCDRNFVY--CNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQS 89
Query: 91 LVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSL 150
+ ++YL GNQL E P LP ++
Sbjct: 90 V--------------------------------------HTVYLYGNQLDEFPMNLPKNV 111
Query: 151 QLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLS 210
++L L+ NNI +I + L +L +E L+L N + +E AF LK+L
Sbjct: 112 RVLHLQENNIQTISRAALAQLLKLEELHLDDN------SISTVGVEDGAFREAISLKLLF 165
Query: 211 LKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPC 270
L N++++VP LP L EL + N IA I + F NL L+ L + GN
Sbjct: 166 LSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNL---------- 215
Query: 271 APCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPP----------------------R 308
N I F LT+LK + NSL H PP
Sbjct: 216 --LTNKG---IAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLT 270
Query: 309 WFKNINKLQELDLSQNFL 326
F N+ KL+ LD+S N L
Sbjct: 271 AFSNLRKLERLDISNNQL 288
Score = 80.9 bits (198), Expect = 6e-15
Identities = 74/246 (30%), Positives = 105/246 (42%), Gaps = 36/246 (14%)
Query: 56 LTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKR 115
L E P +P N L L N+I IS A+ +L L E+ N I
Sbjct: 100 LDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNS------------IST 147
Query: 116 LQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIE 175
+ ++ +F LK L+L N L +P GLP LQ L ++ N I I L ++E
Sbjct: 148 VGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLE 207
Query: 176 ILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPST-LTELYLYN 234
L + N + I + F +LTKLK S+ N+++ P LP T L LYL +
Sbjct: 208 RLIVDGN------LLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQD 261
Query: 235 NMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKV 294
N I I F+NL +L+ LD+S NN + FD L+ LK
Sbjct: 262 NQINHIPLTAFSNLRKLERLDIS-----------------NNQLRMLTQGVFDNLSNLKQ 304
Query: 295 LRLHSN 300
L +N
Sbjct: 305 LTARNN 310
Score = 61.2 bits (147), Expect = 5e-09
Identities = 80/332 (24%), Positives = 133/332 (40%), Gaps = 77/332 (23%)
Query: 519 LKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL--HSTAFEELHKLEVLDISSN 576
++ L+L N I QT++ + L +L L +N + + AF E L++L +S N
Sbjct: 111 VRVLHLQENNI-QTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKN 169
Query: 577 SHYFQSEGITHMLNFTKNLKV-LQKLMMNDNDISSSTSRTMES-ESLRTLEFRGNHLDVL 634
H+ + L V LQ+L +++N I+ + ++ SL L GN +L
Sbjct: 170 ----------HLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGN---LL 216
Query: 635 WREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKK 694
+G F +L KL+E I +NSLS PP+L L +
Sbjct: 217 TNKGIAE--GTFSHLTKLKEFSIVRNSLSH--------PPPDLPGTHLIR---------- 256
Query: 695 LQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDL 754
L L NQ+ +P + R L+ L + NNQ+R LT+ +
Sbjct: 257 ---------LYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDN--------- 298
Query: 755 SSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTC 814
L+NLK L +N + C C W W+ + ++ C
Sbjct: 299 -----------------LSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLN--VRGFMC 339
Query: 815 VGPGAHKGQSV--ISLDLYTCELDLTNLILFS 844
GP +G +V ++++L +C L LF+
Sbjct: 340 QGPEQVRGMAVRELNMNLLSCPTTTPGLPLFT 371
Score = 55.8 bits (133), Expect = 2e-07
Identities = 62/196 (31%), Positives = 85/196 (43%), Gaps = 27/196 (13%)
Query: 496 QTLDLSKNSIFFVKSSD--FQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNR 553
+ L L NSI V D F+ LK L LS N +S G +L+ L NR
Sbjct: 136 EELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLP----VDLQELRVDENR 191
Query: 554 LDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTS 613
+ ++ AF+ L LE L + N ++GI +L L++ + N +S
Sbjct: 192 IAVISDMAFQNLTSLERLIVDGN--LLTNKGIAE--GTFSHLTKLKEFSIVRNSLSHPPP 247
Query: 614 RTMESESLRTLEFRGNHLDVLWREGDNRY----LQLFKNLLKLEELDISKNSLSFLPSGV 669
+ G HL L+ + DN+ L F NL KLE LDIS N L L GV
Sbjct: 248 -----------DLPGTHLIRLYLQ-DNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGV 295
Query: 670 FDGMPPNLKNLSLAKN 685
FD + NLK L+ N
Sbjct: 296 FDNL-SNLKQLTARNN 310
Score = 55.1 bits (131), Expect = 3e-07
Identities = 72/302 (23%), Positives = 127/302 (42%), Gaps = 54/302 (17%)
Query: 132 LYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIR-KENLTELANIEILYLGQNCYYRNPCY 190
+Y + L +P G+P + +L L N I + L + ++ +YL
Sbjct: 47 VYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYL----------- 95
Query: 191 VSYSIEKDAF-LNLTK-LKVLSLKDNNVTAVPTVLPSTLT---ELYLYNNMIAKIQEDD- 244
Y + D F +NL K ++VL L++NN+ + + L EL+L +N I+ + +D
Sbjct: 96 --YGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDG 153
Query: 245 -FNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQ 303
F L++L LS N ++ P+ +PV +L+ LR+ N +
Sbjct: 154 AFREAISLKLLFLSKNH-------------LSSVPVGLPV-------DLQELRVDENRIA 193
Query: 304 HVPPRWFKNINKLQELDLSQNFLA-KEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNL 362
+ F+N+ L+ L + N L K I + F H L+ E + R S L
Sbjct: 194 VISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSH---------LTKLKEFSIVRNS--L 242
Query: 363 SQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKR 422
S L ++R+ ++ L+ NL+ LE LD+ N +++ +F
Sbjct: 243 SHPPPDLPGTHLIRLY-LQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSN 301
Query: 423 LK 424
LK
Sbjct: 302 LK 303
Score = 43.9 bits (102), Expect = 8e-04
Identities = 61/258 (23%), Positives = 108/258 (41%), Gaps = 57/258 (22%)
Query: 213 DNNVTAVPTVLPSTLTELYLYNNMIAKIQ-EDDFNNLNQLQILDLSGNCPRCYNAPFPCA 271
+ ++T+VP +P +T LYL+NN I + +N+ + + L GN
Sbjct: 51 ERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGN------------ 98
Query: 272 PCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAK-EI 330
+ P+ +P N ++VL L N++Q + + KL+EL L N ++ +
Sbjct: 99 -QLDEFPMNLPKN-------VRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGV 150
Query: 331 GDAKF-------LHFLPS--LIQLDLSFNFELQVYRASMN-----LSQAFSSLKSLKILR 376
D F L FL L + + +LQ R N AF +L SL+ L
Sbjct: 151 EDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLI 210
Query: 377 IRGYVF--KELKSFNLSPLHNLQNLEVL---------DL-GTNFIKI---------ANLS 415
+ G + K + S L L+ ++ DL GT+ I++ L+
Sbjct: 211 VDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLT 270
Query: 416 MFKQFKRLKVIDLSVNKI 433
F ++L+ +D+S N++
Sbjct: 271 AFSNLRKLERLDISNNQL 288
Score = 39.3 bits (90), Expect = 0.020
Identities = 43/161 (26%), Positives = 64/161 (39%), Gaps = 21/161 (13%)
Query: 55 HLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIK 114
HL+ +P G+P + L + N I IS +F L L + N +
Sbjct: 170 HLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGN------------LLT 217
Query: 115 RLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPS-LQLLSLEANNIFSIRKENLTELAN 173
I +FS LT LK + N L P LP + L L L+ N I I + L
Sbjct: 218 NKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRK 277
Query: 174 IEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDN 214
+E L + N + + F NL+ LK L+ ++N
Sbjct: 278 LERLDISNN--------QLRMLTQGVFDNLSNLKQLTARNN 310
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,514,973
Number of Sequences: 37866
Number of extensions: 1613266
Number of successful extensions: 8802
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 3971
Number of HSP's gapped (non-prelim): 2039
length of query: 1049
length of database: 18,247,518
effective HSP length: 113
effective length of query: 936
effective length of database: 13,968,660
effective search space: 13074665760
effective search space used: 13074665760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.