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Search of human proteins with 7705696
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705696 thioredoxin domain containing 12 [Homo sapiens]
(172 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705696 thioredoxin domain containing 12 [Homo sapiens] 357 4e-99
gi|28827801 breast cancer membrane protein 11 [Homo sapiens] 89 1e-18
gi|5453541 anterior gradient 2 homolog [Homo sapiens] 87 5e-18
gi|94966757 protein disulfide isomerase A2 [Homo sapiens] 38 0.005
gi|5803121 protein disulfide isomerase A5 [Homo sapiens] 35 0.042
gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens] 35 0.042
gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo s... 33 0.093
gi|21361403 thioredoxin 2 precursor [Homo sapiens] 32 0.35
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 30 1.0
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 30 1.0
gi|50592994 thioredoxin [Homo sapiens] 29 1.8
gi|163644283 proteasome (prosome, macropain) activator subunit 4... 29 1.8
gi|148839372 thioredoxin domain containing 3 [Homo sapiens] 29 2.3
gi|5031973 protein disulfide isomerase A6 [Homo sapiens] 28 3.0
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 28 3.0
gi|157384971 cyclin G associated kinase [Homo sapiens] 28 3.0
gi|4758304 protein disulfide isomerase A4 [Homo sapiens] 28 3.9
gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens] 28 3.9
gi|110835708 solute carrier family 5 (inositol transporters), me... 28 5.1
gi|115392150 hypothetical protein LOC644815 [Homo sapiens] 28 5.1
gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens] 28 5.1
gi|11056016 GC-rich promoter binding protein 1-like 1 [Homo sapi... 27 6.7
gi|151101292 thioredoxin domain containing 1 [Homo sapiens] 27 8.7
>gi|7705696 thioredoxin domain containing 12 [Homo sapiens]
Length = 172
Score = 357 bits (915), Expect = 4e-99
Identities = 172/172 (100%), Positives = 172/172 (100%)
Query: 1 METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVI 60
METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVI
Sbjct: 1 METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVI 60
Query: 61 IHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDP 120
IHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDP
Sbjct: 61 IHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDP 120
Query: 121 SGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL 172
SGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL
Sbjct: 121 SGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL 172
>gi|28827801 breast cancer membrane protein 11 [Homo sapiens]
Length = 166
Score = 89.4 bits (220), Expect = 1e-18
Identities = 59/154 (38%), Positives = 83/154 (53%), Gaps = 14/154 (9%)
Query: 13 LGFSFLLLVISSD----------GHNGLGKGFGDHIHW-RTLEDGKKEAAASGLPLMVII 61
LG LL+ +SS+ L +G+GD I W +T E+G A S PLMVI
Sbjct: 7 LGLCLLLVTVSSNLAIAIKKEKRPPQTLSRGWGDDITWVQTYEEGLFYAQKSKKPLMVIH 66
Query: 62 HKSWCGACKALKPKFAESTEISELSHN-FVMVNLEDEEEPKDEDFSPDGGYIPRILFLDP 120
H C +ALK FA++ EI E++ N F+M+NL E D++ SPDG Y+PRI+F+DP
Sbjct: 67 HLEDCQYSQALKKVFAQNEEIQEMAQNKFIMLNLM--HETTDKNLSPDGQYVPRIMFVDP 124
Query: 121 SGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEA 154
S V +I N Y Y +++ MK+A
Sbjct: 125 SLTVRADIAGRYSNRLYTYEPRDLPLLIENMKKA 158
>gi|5453541 anterior gradient 2 homolog [Homo sapiens]
Length = 175
Score = 87.4 bits (215), Expect = 5e-18
Identities = 50/130 (38%), Positives = 73/130 (56%), Gaps = 3/130 (2%)
Query: 30 LGKGFGDHIHW-RTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHN 88
L +G+GD + W +T E+ ++ S PLM+I H C +ALK FAE+ EI +L+
Sbjct: 44 LSRGWGDQLIWTQTYEEALYKSKTSNKPLMIIHHLDECPHSQALKKVFAENKEIQKLAEQ 103
Query: 89 FVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKYFYVSAEQVV 148
FV++NL E D+ SPDG Y+PRI+F+DPS V +I N Y Y ++
Sbjct: 104 FVLLNLV--YETTDKHLSPDGQYVPRIMFVDPSLTVRADITGRYSNRLYAYEPADTALLL 161
Query: 149 QGMKEAQERL 158
MK+A + L
Sbjct: 162 DNMKKALKLL 171
>gi|94966757 protein disulfide isomerase A2 [Homo sapiens]
Length = 525
Score = 37.7 bits (86), Expect = 0.005
Identities = 19/73 (26%), Positives = 37/73 (50%), Gaps = 4/73 (5%)
Query: 57 LMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGY--IPR 114
L+V + WCG C+AL P+++++ + L+ ++V L + P + + + G P
Sbjct: 62 LLVEFYAPWCGHCQALAPEYSKAAAV--LAAESMVVTLAKVDGPAQRELAEEFGVTEYPT 119
Query: 115 ILFLDPSGKVHPE 127
+ F + HPE
Sbjct: 120 LKFFRNGNRTHPE 132
>gi|5803121 protein disulfide isomerase A5 [Homo sapiens]
Length = 519
Score = 34.7 bits (78), Expect = 0.042
Identities = 11/25 (44%), Positives = 18/25 (72%)
Query: 57 LMVIIHKSWCGACKALKPKFAESTE 81
++V+ H WCG CK +KP+F ++ E
Sbjct: 296 VLVMFHAPWCGHCKKMKPEFEKAAE 320
Score = 34.3 bits (77), Expect = 0.055
Identities = 29/128 (22%), Positives = 56/128 (43%), Gaps = 21/128 (16%)
Query: 33 GFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMV 92
G D +H + +D ++ PL+++ + WC CK + P F ++ ++L + V+
Sbjct: 149 GAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAA--TQLRGHAVLA 206
Query: 93 NL---EDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKY--FYVSAEQV 147
+ E E E++S G P I + E G ++Y + +AE +
Sbjct: 207 GMNVYSSEFENIKEEYSVRG--FPTICYF------------EKGRFLFQYDNYGSTAEDI 252
Query: 148 VQGMKEAQ 155
V+ +K Q
Sbjct: 253 VEWLKNPQ 260
>gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]
Length = 505
Score = 34.7 bits (78), Expect = 0.042
Identities = 18/71 (25%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 57 LMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRIL 116
+++ + WCG CK L+PK+ E E N V+ ++ + G P I
Sbjct: 397 VLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRG--FPTIY 454
Query: 117 FLDPSGKVHPE 127
F + K++P+
Sbjct: 455 FSPANKKLNPK 465
>gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo
sapiens]
Length = 508
Score = 33.5 bits (75), Expect = 0.093
Identities = 14/31 (45%), Positives = 21/31 (67%)
Query: 49 EAAASGLPLMVIIHKSWCGACKALKPKFAES 79
EA A+ L+V + WCG CKAL P++A++
Sbjct: 36 EALAAHKYLLVEFYAPWCGHCKALAPEYAKA 66
>gi|21361403 thioredoxin 2 precursor [Homo sapiens]
Length = 166
Score = 31.6 bits (70), Expect = 0.35
Identities = 18/72 (25%), Positives = 31/72 (43%), Gaps = 3/72 (4%)
Query: 45 DGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDED 104
D + S P++V H WCG CK L P+ ++ H V++ D ++ D
Sbjct: 69 DFQDRVVNSETPVVVDFHAQWCGPCKILGPRL---EKMVAKQHGKVVMAKVDIDDHTDLA 125
Query: 105 FSPDGGYIPRIL 116
+ +P +L
Sbjct: 126 IEYEVSAVPTVL 137
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform
2 [Homo sapiens]
Length = 1562
Score = 30.0 bits (66), Expect = 1.0
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 55 LPLMVIIHKSWCGACKALKPKFAESTEISEL 85
LP ++ IH SWC A K L+ + EIS+L
Sbjct: 822 LPELIEIHNSWCEAMKKLREEGPIIKEISDL 852
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform
1 [Homo sapiens]
Length = 1522
Score = 30.0 bits (66), Expect = 1.0
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 55 LPLMVIIHKSWCGACKALKPKFAESTEISEL 85
LP ++ IH SWC A K L+ + EIS+L
Sbjct: 782 LPELIEIHNSWCEAMKKLREEGPIIKEISDL 812
>gi|50592994 thioredoxin [Homo sapiens]
Length = 105
Score = 29.3 bits (64), Expect = 1.8
Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 6/55 (10%)
Query: 52 ASGLPLMVI-IHKSWCGACKALKPKFAESTEISELSHN--FVMVNLEDEEEPKDE 103
A+G L+V+ +WCG CK +KP F +SE N F+ V+++D ++ E
Sbjct: 17 AAGDKLVVVDFSATWCGPCKMIKPFF---HSLSEKYSNVIFLEVDVDDCQDVASE 68
>gi|163644283 proteasome (prosome, macropain) activator subunit 4
[Homo sapiens]
Length = 1843
Score = 29.3 bits (64), Expect = 1.8
Identities = 16/47 (34%), Positives = 28/47 (59%), Gaps = 2/47 (4%)
Query: 127 EIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRK-KHLEDEL 172
E++ ++ NPS +S E++ +G+K QE+ DA R ++L D L
Sbjct: 1105 ELLQQSKNPSINQILLSPEKIKEGIKRQQEK-NADALRNYENLVDTL 1150
>gi|148839372 thioredoxin domain containing 3 [Homo sapiens]
Length = 588
Score = 28.9 bits (63), Expect = 2.3
Identities = 9/28 (32%), Positives = 21/28 (75%), Gaps = 1/28 (3%)
Query: 58 MVIIHKSWCGACKALKPKFAE-STEISE 84
++ ++++WCG C+A++P F + E++E
Sbjct: 31 VIDVYQAWCGPCRAMQPLFRKLKNELNE 58
>gi|5031973 protein disulfide isomerase A6 [Homo sapiens]
Length = 440
Score = 28.5 bits (62), Expect = 3.0
Identities = 12/28 (42%), Positives = 19/28 (67%), Gaps = 1/28 (3%)
Query: 58 MVIIHKSWCGACKALKPKF-AESTEISE 84
MV + WCG CK L+P++ A ++E+ E
Sbjct: 182 MVEFYAPWCGHCKNLEPEWAAAASEVKE 209
>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
Length = 1522
Score = 28.5 bits (62), Expect = 3.0
Identities = 18/77 (23%), Positives = 34/77 (44%), Gaps = 6/77 (7%)
Query: 68 ACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDED------FSPDGGYIPRILFLDPS 121
AC+++ K + ++ ++L D+EE K + + G I +++ P+
Sbjct: 1195 ACRSVLHKDIGPCRAATITGTLSRISLNDDEEEKGTNPEGLSYSTLPGNVISKVIIQQPT 1254
Query: 122 GKVHPEIINENGNPSYK 138
G P +NE NP K
Sbjct: 1255 GLHMPMSMNELSNPCLK 1271
>gi|157384971 cyclin G associated kinase [Homo sapiens]
Length = 1311
Score = 28.5 bits (62), Expect = 3.0
Identities = 29/109 (26%), Positives = 48/109 (44%), Gaps = 14/109 (12%)
Query: 39 HWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFA----ESTEISELSHNFVMVNL 94
H R+ G+ +A + + + I + A KFA ++ +I E + VNL
Sbjct: 646 HARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNL 705
Query: 95 EDEEEPKDE--------DFSPDGGYIPRILFLDPSGKVHPEIINENGNP 135
E E EP+D + S G P+ILF S + +I+++ G P
Sbjct: 706 EVEVEPRDRPSREAPPWENSSMRGLNPKILF--SSREEQQDILSKFGKP 752
>gi|4758304 protein disulfide isomerase A4 [Homo sapiens]
Length = 645
Score = 28.1 bits (61), Expect = 3.9
Identities = 21/102 (20%), Positives = 40/102 (39%), Gaps = 2/102 (1%)
Query: 57 LMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRIL 116
+++ + WCG CK L+P + + + V+ ++ D G+ P I
Sbjct: 546 VLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGF-PTIY 604
Query: 117 FLDPSGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERL 158
F PSG + E G+ ++ E+ + +E L
Sbjct: 605 FA-PSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL 645
Score = 27.3 bits (59), Expect = 6.7
Identities = 11/31 (35%), Positives = 20/31 (64%), Gaps = 1/31 (3%)
Query: 57 LMVIIHKSWCGACKALKPKFAEST-EISELS 86
++V + WCG CK L P++ ++ E+S+ S
Sbjct: 197 ILVEFYAPWCGHCKKLAPEYEKAAKELSKRS 227
>gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens]
Length = 1226
Score = 28.1 bits (61), Expect = 3.9
Identities = 18/71 (25%), Positives = 33/71 (46%), Gaps = 10/71 (14%)
Query: 45 DGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDED 104
+ ++E A SG + W A K ++P + ++ H + N D+E+ KDE
Sbjct: 519 EAEEEKAKSG-------YDEWIKADKIVRPA---DKNVPKIKHRKKIKNKLDKEKDKDEK 568
Query: 105 FSPDGGYIPRI 115
+SP + R+
Sbjct: 569 YSPKNCKLRRL 579
>gi|110835708 solute carrier family 5 (inositol transporters),
member 3 [Homo sapiens]
Length = 718
Score = 27.7 bits (60), Expect = 5.1
Identities = 20/64 (31%), Positives = 26/64 (40%), Gaps = 13/64 (20%)
Query: 120 PSGK-------VHPEIIN------ENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKK 166
P+GK + PE +N E GNP + AE V Q L G+ RKK
Sbjct: 587 PNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKK 646
Query: 167 HLED 170
+D
Sbjct: 647 ETDD 650
>gi|115392150 hypothetical protein LOC644815 [Homo sapiens]
Length = 823
Score = 27.7 bits (60), Expect = 5.1
Identities = 20/77 (25%), Positives = 38/77 (49%), Gaps = 11/77 (14%)
Query: 81 EISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKYF 140
E+ +SH+ + + E+EP+ E +P ++ L P+G V +++N KY
Sbjct: 302 ELYLMSHSVSLKGIPMEKEPEPEPI-----VLPSVVPLVPAGTVAKKLVNP------KYA 350
Query: 141 YVSAEQVVQGMKEAQER 157
V A+ V + K + E+
Sbjct: 351 LVKAKSVDEIAKISSEK 367
>gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens]
Length = 1312
Score = 27.7 bits (60), Expect = 5.1
Identities = 19/90 (21%), Positives = 39/90 (43%), Gaps = 11/90 (12%)
Query: 34 FGDHIHWRTLEDGKKEAAASGLPLMVIIH--------KSWCGACKALKPKFAESTEISEL 85
+G + + E K++ G ++ ++H W A K ++P + ++
Sbjct: 579 YGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPA---DKNVPKI 635
Query: 86 SHNFVMVNLEDEEEPKDEDFSPDGGYIPRI 115
H + N D+E+ KDE +SP + R+
Sbjct: 636 KHRKKIKNKLDKEKDKDEKYSPKNCKLRRL 665
>gi|11056016 GC-rich promoter binding protein 1-like 1 [Homo
sapiens]
Length = 474
Score = 27.3 bits (59), Expect = 6.7
Identities = 16/42 (38%), Positives = 20/42 (47%), Gaps = 4/42 (9%)
Query: 23 SSDGHNGL----GKGFGDHIHWRTLEDGKKEAAASGLPLMVI 60
SS GH+G+ G G G+H HW +K A P M I
Sbjct: 99 SSRGHDGMSQRSGGGTGNHRHWNGSFHSRKGCAFQEKPPMEI 140
>gi|151101292 thioredoxin domain containing 1 [Homo sapiens]
Length = 280
Score = 26.9 bits (58), Expect = 8.7
Identities = 16/60 (26%), Positives = 28/60 (46%), Gaps = 10/60 (16%)
Query: 39 HWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISE-LSHNFVMVNLEDE 97
+WR L +G M+ + WC AC+ L+P++ E E L N V++ ++
Sbjct: 38 NWRELLEGD---------WMIEFYAPWCPACQNLQPEWESFAEWGEDLEVNIAKVDVTEQ 88
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,429,178
Number of Sequences: 37866
Number of extensions: 358227
Number of successful extensions: 855
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 826
Number of HSP's gapped (non-prelim): 35
length of query: 172
length of database: 18,247,518
effective HSP length: 95
effective length of query: 77
effective length of database: 14,650,248
effective search space: 1128069096
effective search space used: 1128069096
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.