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Search of human proteins with 7705473
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo
sapiens]
(346 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 693 0.0
gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 684 0.0
gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo s... 478 e-135
gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo s... 478 e-135
gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens] 123 3e-28
gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens] 123 3e-28
gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo sa... 111 1e-24
gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo ... 102 5e-22
gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo... 93 4e-19
gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens] 85 8e-17
gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens] 58 1e-08
gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens] 56 5e-08
gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens] 56 5e-08
gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens] 48 1e-05
gi|66363688 NEDD8 activating enzyme E1 subunit 1 isoform c [Homo... 47 2e-05
gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens] 37 0.026
gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens] 37 0.026
gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens] 37 0.026
gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens] 35 0.13
gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens] 35 0.13
gi|193788653 hypothetical protein LOC100131897 [Homo sapiens] 30 4.1
gi|157426887 dedicator of cytokinesis 6 [Homo sapiens] 29 5.4
gi|54112429 dedicator of cytokinesis 7 [Homo sapiens] 29 7.1
gi|189027141 abhydrolase domain containing 6 [Homo sapiens] 28 9.2
gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens] 28 9.2
>gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo
sapiens]
Length = 346
Score = 693 bits (1788), Expect = 0.0
Identities = 346/346 (100%), Positives = 346/346 (100%)
Query: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
Sbjct: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60
Query: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
Sbjct: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120
Query: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEETD 180
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEETD
Sbjct: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEETD 180
Query: 181 VAKVSHGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240
VAKVSHGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
Sbjct: 181 VAKVSHGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240
Query: 241 FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA 300
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
Sbjct: 241 FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA 300
Query: 301 PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK 346
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
Sbjct: 301 PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK 346
>gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo
sapiens]
Length = 346
Score = 684 bits (1765), Expect = 0.0
Identities = 342/346 (98%), Positives = 343/346 (99%)
Query: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
Sbjct: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60
Query: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
Sbjct: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120
Query: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEETD 180
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGD FGYHGYTFANLGEHEFVEE+T
Sbjct: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK 180
Query: 181 VAKVSHGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240
VAKVS GVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
Sbjct: 181 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240
Query: 241 FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA 300
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
Sbjct: 241 FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA 300
Query: 301 PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK 346
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
Sbjct: 301 PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK 346
>gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo
sapiens]
Length = 266
Score = 478 bits (1229), Expect = e-135
Identities = 240/244 (98%), Positives = 241/244 (98%)
Query: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
Sbjct: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60
Query: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
Sbjct: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120
Query: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEETD 180
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGD FGYHGYTFANLGEHEFVEE+T
Sbjct: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK 180
Query: 181 VAKVSHGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240
VAKVS GVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
Sbjct: 181 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240
Query: 241 FLLQ 244
FLLQ
Sbjct: 241 FLLQ 244
>gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo
sapiens]
Length = 299
Score = 478 bits (1229), Expect = e-135
Identities = 240/244 (98%), Positives = 241/244 (98%)
Query: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
Sbjct: 1 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV 60
Query: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
Sbjct: 61 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE 120
Query: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEETD 180
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGD FGYHGYTFANLGEHEFVEE+T
Sbjct: 121 SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK 180
Query: 181 VAKVSHGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240
VAKVS GVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
Sbjct: 181 VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY 240
Query: 241 FLLQ 244
FLLQ
Sbjct: 241 FLLQ 244
>gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens]
Length = 1058
Score = 123 bits (308), Expect = 3e-28
Identities = 104/389 (26%), Positives = 162/389 (41%), Gaps = 65/389 (16%)
Query: 9 GGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDH 68
G ++ + Y RQ+ + G EA KRL+ S VL+ GL+GLG EIAKN+IL GVK +T+ D
Sbjct: 45 GSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQ 104
Query: 69 EQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDA 128
D +QF +R +G+NRAE S R LN V V T + E F + F
Sbjct: 105 GTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPL---VEDFLSGFQV 161
Query: 129 VCLTCCSRDVIVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEE---------- 178
V LT + ++V + CH IK D G G F + GE + +
Sbjct: 162 VVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMV 221
Query: 179 -----------TDVAKVSHGVEDGPDTKRAKL-------------------------DSS 202
T + + HG E G +++ D+S
Sbjct: 222 SMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTS 281
Query: 203 ETTMVKKKVVFCPVKEALEVDWSSEKAK-----------AALKRTTSDYFLLQVLLKFRT 251
+ + + VK ++ + S A A R + Q L +F
Sbjct: 282 NFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCA 341
Query: 252 DKGRDPSSDTYEEDSELLLQIRNDVLDSL-GISPDLLPEDFVR----YCFSEMAPVCAVV 306
GR P E+ +EL+ + +L + + L ED +R ++AP+ A +
Sbjct: 342 QHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFI 401
Query: 307 GGILAQEIVKALSQRDPPHNNFFFFDGMK 335
GG+ AQE++KA S + P + +FD ++
Sbjct: 402 GGLAAQEVMKACSGKFMPIMQWLYFDALE 430
Score = 48.5 bits (114), Expect = 9e-06
Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 14/141 (9%)
Query: 18 QYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV-----KGLTMLDHEQVT 72
+YD Q+ ++G + Q++L + LVG +G E+ KN + G+ + + D + +
Sbjct: 450 RYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIE 509
Query: 73 PEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVK-------VDTEDIEKKPESFFTQ 125
+ QFL R V + +++ + + +NP + V DTE I + FF
Sbjct: 510 KSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERI--YDDDFFQN 567
Query: 126 FDAVCLTCCSRDVIVKVDQIC 146
D V + D + +D+ C
Sbjct: 568 LDGVANALDNVDARMYMDRRC 588
>gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens]
Length = 1058
Score = 123 bits (308), Expect = 3e-28
Identities = 104/389 (26%), Positives = 162/389 (41%), Gaps = 65/389 (16%)
Query: 9 GGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDH 68
G ++ + Y RQ+ + G EA KRL+ S VL+ GL+GLG EIAKN+IL GVK +T+ D
Sbjct: 45 GSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQ 104
Query: 69 EQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDA 128
D +QF +R +G+NRAE S R LN V V T + E F + F
Sbjct: 105 GTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPL---VEDFLSGFQV 161
Query: 129 VCLTCCSRDVIVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEE---------- 178
V LT + ++V + CH IK D G G F + GE + +
Sbjct: 162 VVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMV 221
Query: 179 -----------TDVAKVSHGVEDGPDTKRAKL-------------------------DSS 202
T + + HG E G +++ D+S
Sbjct: 222 SMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTS 281
Query: 203 ETTMVKKKVVFCPVKEALEVDWSSEKAK-----------AALKRTTSDYFLLQVLLKFRT 251
+ + + VK ++ + S A A R + Q L +F
Sbjct: 282 NFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCA 341
Query: 252 DKGRDPSSDTYEEDSELLLQIRNDVLDSL-GISPDLLPEDFVR----YCFSEMAPVCAVV 306
GR P E+ +EL+ + +L + + L ED +R ++AP+ A +
Sbjct: 342 QHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFI 401
Query: 307 GGILAQEIVKALSQRDPPHNNFFFFDGMK 335
GG+ AQE++KA S + P + +FD ++
Sbjct: 402 GGLAAQEVMKACSGKFMPIMQWLYFDALE 430
Score = 48.5 bits (114), Expect = 9e-06
Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 14/141 (9%)
Query: 18 QYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV-----KGLTMLDHEQVT 72
+YD Q+ ++G + Q++L + LVG +G E+ KN + G+ + + D + +
Sbjct: 450 RYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIE 509
Query: 73 PEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVK-------VDTEDIEKKPESFFTQ 125
+ QFL R V + +++ + + +NP + V DTE I + FF
Sbjct: 510 KSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERI--YDDDFFQN 567
Query: 126 FDAVCLTCCSRDVIVKVDQIC 146
D V + D + +D+ C
Sbjct: 568 LDGVANALDNVDARMYMDRRC 588
>gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo
sapiens]
Length = 1012
Score = 111 bits (277), Expect = 1e-24
Identities = 65/171 (38%), Positives = 92/171 (53%), Gaps = 3/171 (1%)
Query: 19 YDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGA 78
Y RQ+ + G A +R++ +RVL+ GL+GLGAE+AKNL+L GV LT+ D D A
Sbjct: 15 YSRQLYVLGSPAMQRIQGARVLVSGLQGLGAEVAKNLVLMGVGSLTLHDPHPTCWSDLAA 74
Query: 79 QFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDV 138
QFL+ + R+RAEAS E LN V V V T DI E F V LT +
Sbjct: 75 QFLLSEQDLERSRAEASQELLAQLNRAVQVVVHTGDI---TEDLLLDFQVVVLTAAKLEE 131
Query: 139 IVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEETDVAKVSHGVE 189
+KV +CHK+ + F D G G F + GE V++ T+ ++ ++
Sbjct: 132 QLKVGTLCHKHGVCFLAADTRGLVGQLFCDFGEDFTVQDPTEAEPLTAAIQ 182
Score = 63.9 bits (154), Expect = 2e-10
Identities = 41/123 (33%), Positives = 65/123 (52%), Gaps = 10/123 (8%)
Query: 17 AQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVK-----GLTMLDHEQV 71
++YD QI ++G Q++LR LLVG +G E+ K L G+ GLT++D + +
Sbjct: 413 SRYDGQIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGLTVVDMDHI 472
Query: 72 TPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE-----SFFTQF 126
+ QFL R+ VGR +AE + A+ LNP + V T ++ E +FF++
Sbjct: 473 ERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPTTEHIYGDNFFSRV 532
Query: 127 DAV 129
D V
Sbjct: 533 DGV 535
Score = 34.7 bits (78), Expect = 0.13
Identities = 12/36 (33%), Positives = 27/36 (75%)
Query: 299 MAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGM 334
++P+ A++G + AQE++KA+S++ P + + +FD +
Sbjct: 357 LSPMVAMLGAVAAQEVLKAISRKFMPLDQWLYFDAL 392
>gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo
sapiens]
Length = 534
Score = 102 bits (254), Expect = 5e-22
Identities = 57/168 (33%), Positives = 86/168 (51%), Gaps = 3/168 (1%)
Query: 18 QYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPG 77
+YDRQ+RLWG Q+ L ++ V L+ G EI KNL+L G+ T++D QV+ ED G
Sbjct: 12 KYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAG 71
Query: 78 AQFLIRTGSVGRNRAEASLERAQNLNPMVD---VKVDTEDIEKKPESFFTQFDAVCLTCC 134
F ++ S+G+NRAEA++E Q LN V V+ E++ SFF +F V T
Sbjct: 72 NNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQL 131
Query: 135 SRDVIVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEETDVA 182
+++ + + I +G GY + EH +E D A
Sbjct: 132 PESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA 179
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/100 (30%), Positives = 48/100 (48%), Gaps = 5/100 (5%)
Query: 240 YFLLQVLLKFRTDKGRDPSSDTY--EEDSELLLQIRNDVLDSLGIS---PDLLPEDFVRY 294
Y +L+ + +F +GR P Y EED L L G+S D +F RY
Sbjct: 426 YLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRY 485
Query: 295 CFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGM 334
+E + A +GG AQE++K ++++ NN + + GM
Sbjct: 486 GAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
>gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo
sapiens]
Length = 528
Score = 92.8 bits (229), Expect = 4e-19
Identities = 53/164 (32%), Positives = 81/164 (49%), Gaps = 3/164 (1%)
Query: 22 QIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFL 81
+ RLWG Q+ L ++ V L+ G EI KNL+L G+ T++D QV+ ED G F
Sbjct: 10 EARLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFF 69
Query: 82 IRTGSVGRNRAEASLERAQNLNPMVD---VKVDTEDIEKKPESFFTQFDAVCLTCCSRDV 138
++ S+G+NRAEA++E Q LN V V+ E++ SFF +F V T
Sbjct: 70 LQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPEST 129
Query: 139 IVKVDQICHKNSIKFFTGDAFGYHGYTFANLGEHEFVEEETDVA 182
+++ + + I +G GY + EH +E D A
Sbjct: 130 SLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA 173
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/100 (30%), Positives = 48/100 (48%), Gaps = 5/100 (5%)
Query: 240 YFLLQVLLKFRTDKGRDPSSDTY--EEDSELLLQIRNDVLDSLGIS---PDLLPEDFVRY 294
Y +L+ + +F +GR P Y EED L L G+S D +F RY
Sbjct: 420 YLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRY 479
Query: 295 CFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGM 334
+E + A +GG AQE++K ++++ NN + + GM
Sbjct: 480 GAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 519
>gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens]
Length = 1052
Score = 85.1 bits (209), Expect = 8e-17
Identities = 59/172 (34%), Positives = 84/172 (48%), Gaps = 5/172 (2%)
Query: 13 EEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVT 72
E + A Y RQ + G A +++ S V L G+ GLG EIAKNL+LAG+K +T+ D E+
Sbjct: 38 EIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQ 97
Query: 73 PEDPGAQFLIRTGSV--GRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE-SFFTQFDAV 129
D G F + V RNRAEA L+ LNP V V + + + SF ++ V
Sbjct: 98 AWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCV 157
Query: 130 CLTCCSRDVIVKVDQICHKN--SIKFFTGDAFGYHGYTFANLGEHEFVEEET 179
LT + K++ C IKF + D G F + G+ V + T
Sbjct: 158 VLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTT 209
Score = 39.3 bits (90), Expect = 0.005
Identities = 34/131 (25%), Positives = 67/131 (51%), Gaps = 15/131 (11%)
Query: 218 EALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVL 277
+ L VD+S+ +A + + + L +F+ R P+ ++DSE LL++ +
Sbjct: 310 KCLIVDFSNPEAPLEI------HTAMLALDQFQEKYSRKPNVGC-QQDSEELLKLATSIS 362
Query: 278 DSLGISPDLLPEDFVRYCF----SEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDG 333
++L PD+ D V + ++P+ A VGG+ +QE++KA++ + P + +
Sbjct: 363 ETLEEKPDV-NADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLY--- 418
Query: 334 MKGNGIVECLG 344
++ IVE LG
Sbjct: 419 LEAADIVESLG 429
Score = 39.3 bits (90), Expect = 0.005
Identities = 31/145 (21%), Positives = 59/145 (40%), Gaps = 11/145 (7%)
Query: 32 KRLRASRVLLVGLKGLGAEIAKNLILAGV-----KG-LTMLDHEQVTPEDPGAQFLIRTG 85
++L+ + LVG +G E+ KN L GV KG +T+ D + + + QFL R
Sbjct: 456 QKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPH 515
Query: 86 SVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPES-----FFTQFDAVCLTCCSRDVIV 140
+ + ++ + + +N + + + E+ F+T+ D + + +
Sbjct: 516 HIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARR 575
Query: 141 KVDQICHKNSIKFFTGDAFGYHGYT 165
VD C N G G+T
Sbjct: 576 YVDSRCLANLRPLLDSGTMGTKGHT 600
>gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens]
Length = 640
Score = 57.8 bits (138), Expect = 1e-08
Identities = 38/138 (27%), Positives = 63/138 (45%), Gaps = 4/138 (2%)
Query: 29 EAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVG 88
E + + RVL+VG G+G E+ KNL+L G + ++D + + + QFL + VG
Sbjct: 10 ELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVG 69
Query: 89 RNRAEASLERAQNLNPMVDVKVDTEDIEKKPE---SFFTQFDAVCLTCCSRDVIVKVDQI 145
R++A+ + E P ++ V D P+ FF QF V +R V+++
Sbjct: 70 RSKAQVAKESVLQFYPKANI-VAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRM 128
Query: 146 CHKNSIKFFTGDAFGYHG 163
C + GY G
Sbjct: 129 CLAADVPLIESGTAGYLG 146
>gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens]
Length = 449
Score = 55.8 bits (133), Expect = 5e-08
Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%)
Query: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93
L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE
Sbjct: 53 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 112
Query: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140
+ E + P +V I+ ++F+ QF + C D I+
Sbjct: 113 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 156
>gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens]
Length = 463
Score = 55.8 bits (133), Expect = 5e-08
Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 3/107 (2%)
Query: 34 LRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAE 93
L +VL++G GLG E+ KNL L+G + + ++D + + + QFL R +GR +AE
Sbjct: 67 LDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAE 126
Query: 94 ASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIV 140
+ E + P +V I+ ++F+ QF + C D I+
Sbjct: 127 VAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHII---VCGLDSII 170
>gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens]
Length = 460
Score = 48.1 bits (113), Expect = 1e-05
Identities = 32/99 (32%), Positives = 52/99 (52%), Gaps = 2/99 (2%)
Query: 11 ISEEEAAQYDRQIRL--WGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDH 68
+S +E +Y RQ+ L G+ Q RL + VL+VG GLG +A+ L AGV L ++D+
Sbjct: 55 LSRDEILRYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDY 114
Query: 69 EQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD 107
+ V + Q L G+ +A ++ + LN V+
Sbjct: 115 DVVEMSNLARQVLHGEALAGQAKAFSAAASLRRLNSAVE 153
>gi|66363688 NEDD8 activating enzyme E1 subunit 1 isoform c [Homo
sapiens]
Length = 445
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/100 (30%), Positives = 48/100 (48%), Gaps = 5/100 (5%)
Query: 240 YFLLQVLLKFRTDKGRDPSSDTY--EEDSELLLQIRNDVLDSLGIS---PDLLPEDFVRY 294
Y +L+ + +F +GR P Y EED L L G+S D +F RY
Sbjct: 337 YLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRY 396
Query: 295 CFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGM 334
+E + A +GG AQE++K ++++ NN + + GM
Sbjct: 397 GAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 436
Score = 29.3 bits (64), Expect = 5.4
Identities = 22/90 (24%), Positives = 35/90 (38%), Gaps = 3/90 (3%)
Query: 96 LERAQNLNPMVD---VKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIK 152
+E Q LN V V+ E++ SFF +F V T +++ + + I
Sbjct: 1 MEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIP 60
Query: 153 FFTGDAFGYHGYTFANLGEHEFVEEETDVA 182
+G GY + EH +E D A
Sbjct: 61 LLICRTYGLVGYMRIIIKEHPVIESHPDNA 90
>gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens]
Length = 623
Score = 37.0 bits (84), Expect = 0.026
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 6/123 (4%)
Query: 38 RVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSV---GRNRAEA 94
+ LL+G LG +A+ L+ GV+ +T +D+ +++ +P Q L G+ +A A
Sbjct: 318 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 377
Query: 95 SLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFF 154
+ +R Q + P V+ + I F +V L RDV +++Q+ + + F
Sbjct: 378 AADRLQKIFPGVNARGFNMSIPMPGHP--VNFSSVTLEQARRDV-EQLEQLIESHDVVFL 434
Query: 155 TGD 157
D
Sbjct: 435 LMD 437
>gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens]
Length = 676
Score = 37.0 bits (84), Expect = 0.026
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 6/123 (4%)
Query: 38 RVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSV---GRNRAEA 94
+ LL+G LG +A+ L+ GV+ +T +D+ +++ +P Q L G+ +A A
Sbjct: 357 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 416
Query: 95 SLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFF 154
+ +R Q + P V+ + I F +V L RDV +++Q+ + + F
Sbjct: 417 AADRLQKIFPGVNARGFNMSIPMPGHP--VNFSSVTLEQARRDV-EQLEQLIESHDVVFL 473
Query: 155 TGD 157
D
Sbjct: 474 LMD 476
>gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens]
Length = 703
Score = 37.0 bits (84), Expect = 0.026
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 6/123 (4%)
Query: 38 RVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSV---GRNRAEA 94
+ LL+G LG +A+ L+ GV+ +T +D+ +++ +P Q L G+ +A A
Sbjct: 357 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALA 416
Query: 95 SLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFF 154
+ +R Q + P V+ + I F +V L RDV +++Q+ + + F
Sbjct: 417 AADRLQKIFPGVNARGFNMSIPMPGHP--VNFSSVTLEQARRDV-EQLEQLIESHDVVFL 473
Query: 155 TGD 157
D
Sbjct: 474 LMD 476
>gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens]
Length = 348
Score = 34.7 bits (78), Expect = 0.13
Identities = 21/84 (25%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 32 KRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNR 91
+++R V +VG+ G+G+ A+ L G+ L + D+++V + F + G ++
Sbjct: 13 EKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSK 71
Query: 92 AEASLERAQNLNPMVDVKVDTEDI 115
+A+ +N+NP V +V +I
Sbjct: 72 VQAAEHTLRNINPDVLFEVHNYNI 95
>gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens]
Length = 404
Score = 34.7 bits (78), Expect = 0.13
Identities = 21/84 (25%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 32 KRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNR 91
+++R V +VG+ G+G+ A+ L G+ L + D+++V + F + G ++
Sbjct: 69 EKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSK 127
Query: 92 AEASLERAQNLNPMVDVKVDTEDI 115
+A+ +N+NP V +V +I
Sbjct: 128 VQAAEHTLRNINPDVLFEVHNYNI 151
>gi|193788653 hypothetical protein LOC100131897 [Homo sapiens]
Length = 535
Score = 29.6 bits (65), Expect = 4.1
Identities = 23/69 (33%), Positives = 34/69 (49%), Gaps = 4/69 (5%)
Query: 168 NLGEHEFVEEETDVAKVSHGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEV-DWSS 226
NL E + V + +++ +EDGP +R K+ + V K PV LE W S
Sbjct: 137 NLSEQDIVSSDLAYLRLAQHLEDGP--RRVKVSHAFLPRVPKVQSNGPVSICLEAGTWRS 194
Query: 227 -EKAKAALK 234
EKA AA++
Sbjct: 195 LEKATAAIQ 203
>gi|157426887 dedicator of cytokinesis 6 [Homo sapiens]
Length = 2047
Score = 29.3 bits (64), Expect = 5.4
Identities = 14/34 (41%), Positives = 23/34 (67%), Gaps = 3/34 (8%)
Query: 160 GYHGYTFANLGEHEFVEEE---TDVAKVSHGVED 190
G++G F +L E EFV +E T +A++SH +E+
Sbjct: 1755 GFYGAHFGDLDEQEFVYKEPSITKLAEISHRLEE 1788
>gi|54112429 dedicator of cytokinesis 7 [Homo sapiens]
Length = 2109
Score = 28.9 bits (63), Expect = 7.1
Identities = 14/33 (42%), Positives = 22/33 (66%), Gaps = 3/33 (9%)
Query: 160 GYHGYTFANLGEHEFVEEE---TDVAKVSHGVE 189
G++G F +L E EFV +E T +A++SH +E
Sbjct: 1815 GFYGTKFGDLDEQEFVYKEPAITKLAEISHRLE 1847
>gi|189027141 abhydrolase domain containing 6 [Homo sapiens]
Length = 337
Score = 28.5 bits (62), Expect = 9.2
Identities = 19/77 (24%), Positives = 39/77 (50%), Gaps = 10/77 (12%)
Query: 257 PSSDTYEEDSELLLQIR----NDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQ 312
P+ Y D++ + +++ + ++ + + P PE+ SEM +C+ V + Q
Sbjct: 173 PAGLQYSTDNQFVQRLKELQGSAAVEKIPLIPST-PEEM-----SEMLQLCSYVRFKVPQ 226
Query: 313 EIVKALSQRDPPHNNFF 329
+I++ L PHNNF+
Sbjct: 227 QILQGLVDVRIPHNNFY 243
>gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]
Length = 1626
Score = 28.5 bits (62), Expect = 9.2
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 256 DPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIV 315
D SS +ED E + Q +++D+ + PD VRY S+ +G +QE V
Sbjct: 44 DTSSSVGKEDFEKVRQWVANLVDTFEVGPDRTRVGVVRY--SDRPTTAFELGLFGSQEEV 101
Query: 316 KALSQR 321
KA ++R
Sbjct: 102 KAAARR 107
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,018,867
Number of Sequences: 37866
Number of extensions: 550797
Number of successful extensions: 1508
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1463
Number of HSP's gapped (non-prelim): 42
length of query: 346
length of database: 18,247,518
effective HSP length: 103
effective length of query: 243
effective length of database: 14,347,320
effective search space: 3486398760
effective search space used: 3486398760
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.