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Search of human proteins with 7705415
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705415 hook homolog 1 [Homo sapiens]
(728 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705415 hook homolog 1 [Homo sapiens] 1419 0.0
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 790 0.0
gi|154354985 hook homolog 2 isoform 1 [Homo sapiens] 639 0.0
gi|154354987 hook homolog 2 isoform 2 [Homo sapiens] 635 0.0
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 150 3e-36
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 150 3e-36
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 150 5e-36
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 107 4e-23
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 106 7e-23
gi|31982906 cingulin-like 1 [Homo sapiens] 105 1e-22
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 105 2e-22
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 104 3e-22
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 102 1e-21
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 102 2e-21
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 101 3e-21
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 101 3e-21
gi|55770834 centromere protein F [Homo sapiens] 101 3e-21
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 100 4e-21
gi|21735548 centrosomal protein 2 [Homo sapiens] 100 5e-21
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 100 5e-21
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 100 5e-21
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 99 1e-20
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 99 1e-20
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 99 2e-20
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 99 2e-20
gi|50083279 centrosome protein 4 [Homo sapiens] 99 2e-20
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 99 2e-20
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 98 2e-20
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 98 3e-20
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 97 4e-20
>gi|7705415 hook homolog 1 [Homo sapiens]
Length = 728
Score = 1419 bits (3673), Expect = 0.0
Identities = 728/728 (100%), Positives = 728/728 (100%)
Query: 1 MEETQPPPQPKLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWL 60
MEETQPPPQPKLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWL
Sbjct: 1 MEETQPPPQPKLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWL 60
Query: 61 SRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRL 120
SRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRL
Sbjct: 61 SRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRL 120
Query: 121 LQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQL 180
LQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQL
Sbjct: 121 LQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQL 180
Query: 181 KRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPN 240
KRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPN
Sbjct: 181 KRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPN 240
Query: 241 TVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETR 300
TVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETR
Sbjct: 241 TVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETR 300
Query: 301 ALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEE 360
ALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEE
Sbjct: 301 ALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEE 360
Query: 361 LKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQR 420
LKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQR
Sbjct: 361 LKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQR 420
Query: 421 DTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQ 480
DTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQ
Sbjct: 421 DTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQ 480
Query: 481 QEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEG 540
QEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEG
Sbjct: 481 QEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEG 540
Query: 541 ESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMK 600
ESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMK
Sbjct: 541 ESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMK 600
Query: 601 AMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDY 660
AMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDY
Sbjct: 601 AMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDY 660
Query: 661 EEKLIVSAWYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSV 720
EEKLIVSAWYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSV
Sbjct: 661 EEKLIVSAWYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSV 720
Query: 721 KVPATTSD 728
KVPATTSD
Sbjct: 721 KVPATTSD 728
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 790 bits (2041), Expect = 0.0
Identities = 421/718 (58%), Positives = 539/718 (75%), Gaps = 19/718 (2%)
Query: 14 LCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDNWRI 73
LC+SL+ W+QTFN +PCQ V+ LT+GV MAQVL +ID A+F+E+WL+RIK +VGDNWR+
Sbjct: 12 LCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRL 71
Query: 74 KASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAINCEK 133
K SN+KK+L+GI+ Y HE LGQQI++ +PD+N I E SD ELGR+LQLILGCA+NCE+
Sbjct: 72 KISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQ 131
Query: 134 KQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAE 193
KQE+IQ IM +EESVQHVVMTAIQELMSKE S NDA +L++QLK+ EEL EAL+
Sbjct: 132 KQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSA 191
Query: 194 KEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQ 253
KEE+ QRC ELDMQV LQ+EK+SL++EN+++ E+L+Q D S +DPN+ +++ Q Q
Sbjct: 192 KEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSD-SIEDPNSPAGRRHLQLQTQ 250
Query: 254 LEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATS 313
LEQLQEE FRLEAAKDDYR+ CEELEK++ E + +NDELT+LA+E ++LKDEIDVLR +S
Sbjct: 251 LEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSS 310
Query: 314 DKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLET 373
DK +KLE VE Y++KL+DL DLR+QVK L+E N MYM NTVSLEEEL+KANAAR+QLET
Sbjct: 311 DKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLET 370
Query: 374 YKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCS 433
YKRQV +L +LS ESK+AD L FE KRL+EK ++L KEK+RL +RD+LKET EELRC
Sbjct: 371 YKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCV 430
Query: 434 QVQQDHLNQ---TDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIE 490
Q Q+ L + +S ++LAAEI+ E RE IRLQHENKML+L QEGS+NE+I
Sbjct: 431 QAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIA 490
Query: 491 ELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKL 550
LQ L+ + + NELETE RL +R+ E+Q Q+E+LQKSLQ+QGSK+ E S LK+KL
Sbjct: 491 LLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKA--EDSVLLKKKL 548
Query: 551 EAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYL 610
E H+EKL E + ELQKK+ +IEDL+P N + KI EL+ AL+KK+E+MK MEERYK YL
Sbjct: 549 EEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYL 608
Query: 611 EKARNVIKTLDPKLNPASA-EIMLLRKQLAEKERRIEILESECKVAKF-RDYEEKLIVSA 668
EKA++VI+TLDPK N +A EI L+ QL E++R LE E + K R+ EEK IVSA
Sbjct: 609 EKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSA 668
Query: 669 WYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSVKV-PAT 725
WYN + K E RL S G +SFLA+QR T++RR+ V PAT
Sbjct: 669 WYNMGMTLHKKAAEDRLASTGS----------GQSFLARQRQATSSRRSYPGHVQPAT 716
>gi|154354985 hook homolog 2 isoform 1 [Homo sapiens]
Length = 719
Score = 639 bits (1647), Expect = 0.0
Identities = 347/714 (48%), Positives = 488/714 (68%), Gaps = 24/714 (3%)
Query: 11 KLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDN 70
K LC SL+ WLQTF+ SPC + L+SG+A+A VL+QID +WFNE+WL I ED G N
Sbjct: 5 KAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGPN 64
Query: 71 WRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAIN 130
W++K SN+K VL+ ++ Y + L +SE +PD++ I E SDP ELG+LLQL+LGCAI+
Sbjct: 65 WKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGCAIS 124
Query: 131 CEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEA 190
CEKKQ+HIQ IMTLEESVQHVVM AIQELM+K+ S + G + Q +R L E
Sbjct: 125 CEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYF-LSEE 183
Query: 191 LAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHA 250
E +EL+QRC +L+ Q+ L +EK SL EN + E++ + +G + + AKK
Sbjct: 184 AEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG--EGTPGLTAKKLLLL 241
Query: 251 QLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLR 310
Q QLEQLQEENFRLE+ ++D R+ C ELE+++ E QHRN LTSLA+E +ALKDE+D LR
Sbjct: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
Query: 311 ATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQ 370
+S++A +LE+T+ R++L +L +LR+QV+ L+E N + T LE+EL++A + R Q
Sbjct: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQ 361
Query: 371 LETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEEL 430
LE +RQVQ+L + E+ +A+ FE + LEEK+E++ KEKERL+ +RD+L+E NEEL
Sbjct: 362 LEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEEL 421
Query: 431 RCSQVQQDHLNQTDAS---ATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENE 487
RC+Q+Q L Q D S + +NLAAEI+P E RE +RLQ ENK L +QE ++ E
Sbjct: 422 RCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRL-CRQEAADRE 480
Query: 488 RIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLK 547
R EELQ LE +R + LET+ RL+++++ EL+ Q+EDLQK+LQEQG K+E S LK
Sbjct: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK 540
Query: 548 QKLEAHMEKLTEVHEELQKKQELIEDLQPDINQN-VQKINELEAALQKKDEDMKAMEERY 606
+KLE H++KL E ELQ+K+E IE+L+P + + ++I EL+ LQKKD D++AMEERY
Sbjct: 541 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 600
Query: 607 KMYLEKARNVIKTLDPKLNPASA---EIMLLRKQLAEKERRIEILESECKVAKF-RDYEE 662
+ Y++KAR V++T++PK PA+ E+ LR QL E++ RI LE + + ++ R+ EE
Sbjct: 601 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 660
Query: 663 KLIVSAWYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRR 716
KL++SAWYN +A Q+ E R A A+SFLAQQR TN+RR
Sbjct: 661 KLLISAWYNMGMALQQRAGEER------------APAHAQSFLAQQRLATNSRR 702
>gi|154354987 hook homolog 2 isoform 2 [Homo sapiens]
Length = 717
Score = 635 bits (1638), Expect = 0.0
Identities = 347/714 (48%), Positives = 488/714 (68%), Gaps = 26/714 (3%)
Query: 11 KLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDN 70
K LC SL+ WLQTF+ SPC + L+SG+A+A VL+QID +WFNE+WL I ED G N
Sbjct: 5 KAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGPN 64
Query: 71 WRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAIN 130
W++K SN+K VL+ ++ Y + L +SE +PD++ I E SDP ELG+LLQL+LGCAI+
Sbjct: 65 WKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGCAIS 124
Query: 131 CEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEA 190
CEKKQ+HIQ IMTLEESVQHVVM AIQELM+K+ S + G + Q +R L E
Sbjct: 125 CEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYF-LSEE 183
Query: 191 LAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHA 250
E +EL+QRC +L+ Q+ L +EK SL EN + E++ + +G + + AKK
Sbjct: 184 AEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG--EGTPGLTAKKLLLL 241
Query: 251 QLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLR 310
Q QLEQLQEENFRLE+ ++D R+ C ELE+++ E QHRN LTSLA+E +ALKDE+D LR
Sbjct: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
Query: 311 ATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQ 370
+S++A +LE+T+ R++L +L +LR+QV+ L+E N + T LE+EL++A + R Q
Sbjct: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQ 361
Query: 371 LETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEEL 430
LE +RQVQ+L + E+ +A+ FE + LEEK+E++ KEKERL+ +RD+L+E NEEL
Sbjct: 362 LEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEEL 421
Query: 431 RCSQVQQDHLNQTDAS---ATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENE 487
RC+Q+Q L Q D S + +NLAAEI+P E RE +RLQ ENK L +QE ++ E
Sbjct: 422 RCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRL-CRQEAADRE 480
Query: 488 RIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLK 547
R EELQ LE +R + LET+ RL+++++ EL+ Q+EDLQK+LQEQG K+ E S LK
Sbjct: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKT--EDSILLK 538
Query: 548 QKLEAHMEKLTEVHEELQKKQELIEDLQPDINQN-VQKINELEAALQKKDEDMKAMEERY 606
+KLE H++KL E ELQ+K+E IE+L+P + + ++I EL+ LQKKD D++AMEERY
Sbjct: 539 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 598
Query: 607 KMYLEKARNVIKTLDPKLNPASA---EIMLLRKQLAEKERRIEILESECKVAKF-RDYEE 662
+ Y++KAR V++T++PK PA+ E+ LR QL E++ RI LE + + ++ R+ EE
Sbjct: 599 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 658
Query: 663 KLIVSAWYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRR 716
KL++SAWYN +A Q+ E R A A+SFLAQQR TN+RR
Sbjct: 659 KLLISAWYNMGMALQQRAGEER------------APAHAQSFLAQQRLATNSRR 700
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 150 bits (380), Expect = 3e-36
Identities = 171/718 (23%), Positives = 303/718 (42%), Gaps = 107/718 (14%)
Query: 18 LMIWLQTFN-----TASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDNWR 72
L+ W++TF + + L GV + QV+ QI+ ++ R+ + V ++
Sbjct: 18 LVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQ----RVNKKVNNDAS 73
Query: 73 IKASNVKKVLQGIMSYYHEFLGQQIS----EALIPDLNQITECSDPVELGRLLQLILGCA 128
++ N+ +++ I YY E L Q I LI N +E E+ +LL L+LGCA
Sbjct: 74 LRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSE-QGTEEVKKLLLLLLGCA 132
Query: 129 INCEKKQEHIQNIMTLEESVQHVVMTAIQE----------LMSKEILSSPPNDAVGELEQ 178
+ C+KK+E I+ I L+ + V IQE L E+ D L+
Sbjct: 133 VQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKN 192
Query: 179 Q---LKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGS 235
LKR ++E E EL + + L ++ S E L
Sbjct: 193 MALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE 252
Query: 236 FDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSL 295
D + + + + EQL D + E++E +L Q N L S
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLL-----------DCKQELEQMEIELKRLQQENMNLLSD 301
Query: 296 AEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTV 355
A R +DE+D LR + + +KLES V Y+++L D+ + +V+ L+E N + +
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361
Query: 356 SLEEELKKANAARTQLE-------TYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEA 408
LE++L+ A +L K ++ D+ ++ + K+ + L E LE +
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 409 LLKEKERLIEQRDTLKETNEELRCSQVQQDH------------LNQTDASATKSYENLAA 456
+ E L + + + T+E Q H L + S TK+ E L
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 457 EIMPVE-YREVFIRLQHENKMLRLQQEGSENERIEELQ----------EQLEQKHRKMNE 505
+ VE ++++ EN+ L + E ENE ++E Q + +++K +
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKT 541
Query: 506 LETEQRLSKERIRELQQQIEDLQKSLQEQGSKSE---------------------GESSS 544
+ET + S+ +I+ L+Q+ E L +++ +S+ E+SS
Sbjct: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS 601
Query: 545 KLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMK---- 600
KL K+E ++ + E ++K E E+L+ +++ +++K NEL LQKK ++K
Sbjct: 602 KL-SKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKENEL---LQKKITNLKITCE 656
Query: 601 ---AME------ERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILE 649
A+E ER L+K + K L +L E L ++ E R +E L+
Sbjct: 657 KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK 714
Score = 92.0 bits (227), Expect = 2e-18
Identities = 111/576 (19%), Positives = 264/576 (45%), Gaps = 63/576 (10%)
Query: 136 EHIQNIMTLEESVQHVVMTAIQELMSKEILS-SPPNDAVGELEQQLKRALEELQEALAEK 194
E I L E+ Q + + EL S +L N ++ + ++L+ ++ ++ ++
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493
Query: 195 EELRQRCEELDMQVTTLQDE----KNSLVS----ENEMMNEKLDQLDGSFDDPNTVVAKK 246
++ + + L +V L++E K SL + ++M EK QL+ + +
Sbjct: 494 LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA-QLEKTIETLRE----- 547
Query: 247 YFHAQLQLEQLQEENFRLEAAKDDYRVHCE----------ELEKQLIE--FQHRNDELTS 294
+++ Q++ L++EN L R + E E +++ + + +L+
Sbjct: 548 --NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 605
Query: 295 LAEETRALKDEIDVLRATSDKANKLESTV-------EIYRQKLQDLNDLRKQVKTLQETN 347
+ E R +K E++ + ++A +LE+ + E+ ++K+ +L ++++ L++ N
Sbjct: 606 IEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN 665
Query: 348 MMYMHNTVSLEEELKKANAARTQLETYKR---QVQDLHVKLSSESKRADTLAFEMKRLEE 404
L++ L QLE+ ++ Q+ + +++L + + +M +L+
Sbjct: 666 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 405 KHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYR 464
+++ L EKE+L + + LK + ++ +V L+ + K+ EN +I +E
Sbjct: 726 ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
Query: 465 EVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQI 524
+ ++++ L++ ++R+E+L+++ + ++ ++LE +++ ++ + L+QQ
Sbjct: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 525 EDLQKSLQEQGSK--SEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNV 582
E +L+E K + + + L +++ + E + E ++ +EL++ DI V
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 583 QKINEL---EAALQKKDEDM-KAMEERYKMYLEKAR----------NVIKTLDPKLNPAS 628
+L + Q+ + D+ K E K+ L K R + K L+ KL
Sbjct: 906 TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST- 964
Query: 629 AEIMLLRKQLAEKERRIEILESECKVAKFRDYEEKL 664
L+K L KE +I LE+ ++ + +Y ++L
Sbjct: 965 -----LKKSLEIKEEKIAALEA--RLEESTNYNQQL 993
Score = 84.3 bits (207), Expect = 4e-16
Identities = 100/480 (20%), Positives = 208/480 (43%), Gaps = 56/480 (11%)
Query: 175 ELEQQ-LKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLD 233
E+E Q L++ LEEL+ + E+L + + L+ + + L+ +K L EN+ + ++ + D
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 234 GSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELT 293
+ ++ N +++ L++EN L Y+ C L+ E + N EL
Sbjct: 850 TTLEENN-----------VKIGNLEKENKTLSKEIGIYKESCVRLK----ELEKENKEL- 893
Query: 294 SLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKL---QDLNDLRKQVKTLQETNM-- 348
V RAT D + ++ +KL Q NDL K L++ +
Sbjct: 894 --------------VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 349 -MYMHNTVSLEE------ELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKR 401
+H+ S ++ E K + + LE + ++ L +L + L E+K
Sbjct: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
Query: 402 LEEKHEAL--LKEKERLIEQRDTL--KETNEELRCSQVQQDHLNQTDASATKSYENLAAE 457
+++ +EAL +++ER+++ + ++ E + ++ L D N +
Sbjct: 1000 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1059
Query: 458 IMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERI 517
+ +L+ +N L+ Q + + + LQEQ + +L+ E +
Sbjct: 1060 AEKQALKTQLKQLETQNNNLQAQILALQRQTV-SLQEQNTTLQTQNAKLQVENSTLNSQS 1118
Query: 518 RELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQ-P 576
L Q + Q +Q+ ++E ES K ++ L++ + L + HE+L EL+ + Q
Sbjct: 1119 TSLMNQ--NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL----ELLHERQAS 1172
Query: 577 DINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRK 636
+ + K L++A + + + + +E+RY L K + ++ L+ L +++L K
Sbjct: 1173 EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLL-KQKGQLEDLEKMLKVEQEKMLLENK 1231
Score = 76.3 bits (186), Expect = 1e-13
Identities = 96/458 (20%), Positives = 195/458 (42%), Gaps = 42/458 (9%)
Query: 135 QEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEK 194
Q+ Q + T++++ + + +E M + SSPP + + + E QE E
Sbjct: 991 QQLRQELKTVKKNYEALKQRQDEERM---VQSSPP------ISGEDNKWERESQETTREL 1041
Query: 195 EELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQL 254
+++ R E++ TLQ EK +L ++ L QL+ N + + Q Q
Sbjct: 1042 LKVKDRLIEVERNNATLQAEKQALKTQ-------LKQLETQ----NNNLQAQILALQRQT 1090
Query: 255 EQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDEL----TSLAEETRALKDEIDVLR 310
LQE+N L+ +V L Q ++N +L +SL E ++ E + L+
Sbjct: 1091 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1150
Query: 311 ATSDKANKLESTVEI-YRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAART 369
+ D K +E+ + ++ + L + TL+ + LE+ + +
Sbjct: 1151 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1210
Query: 370 QLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEE 429
QLE ++ ++ K+ E+K +T+A E K+L +++ L +L+++ + L+ ++
Sbjct: 1211 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1270
Query: 430 LRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERI 489
L+ S + L QT A + L + ++ + Q E L Q +G+ E
Sbjct: 1271 LK-SLLNNSKLEQTRLEA--EFSKLKEQYQQLDITSTKLNNQCE---LLSQLKGNLEEEN 1324
Query: 490 EELQEQ-----------LEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKS 538
L +Q LEQ + EQR +++ EL++Q E L++ + +Q
Sbjct: 1325 RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFY 1384
Query: 539 EGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQP 576
+ + + M KL + +++ ++++ L P
Sbjct: 1385 DPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTP 1422
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 150 bits (380), Expect = 3e-36
Identities = 171/718 (23%), Positives = 303/718 (42%), Gaps = 107/718 (14%)
Query: 18 LMIWLQTFN-----TASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDNWR 72
L+ W++TF + + L GV + QV+ QI+ ++ R+ + V ++
Sbjct: 18 LVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQ----RVNKKVNNDAS 73
Query: 73 IKASNVKKVLQGIMSYYHEFLGQQIS----EALIPDLNQITECSDPVELGRLLQLILGCA 128
++ N+ +++ I YY E L Q I LI N +E E+ +LL L+LGCA
Sbjct: 74 LRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSE-QGTEEVKKLLLLLLGCA 132
Query: 129 INCEKKQEHIQNIMTLEESVQHVVMTAIQE----------LMSKEILSSPPNDAVGELEQ 178
+ C+KK+E I+ I L+ + V IQE L E+ D L+
Sbjct: 133 VQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKN 192
Query: 179 Q---LKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGS 235
LKR ++E E EL + + L ++ S E L
Sbjct: 193 MALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE 252
Query: 236 FDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSL 295
D + + + + EQL D + E++E +L Q N L S
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLL-----------DCKQELEQMEIELKRLQQENMNLLSD 301
Query: 296 AEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTV 355
A R +DE+D LR + + +KLES V Y+++L D+ + +V+ L+E N + +
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361
Query: 356 SLEEELKKANAARTQLE-------TYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEA 408
LE++L+ A +L K ++ D+ ++ + K+ + L E LE +
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 409 LLKEKERLIEQRDTLKETNEELRCSQVQQDH------------LNQTDASATKSYENLAA 456
+ E L + + + T+E Q H L + S TK+ E L
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 457 EIMPVE-YREVFIRLQHENKMLRLQQEGSENERIEELQ----------EQLEQKHRKMNE 505
+ VE ++++ EN+ L + E ENE ++E Q + +++K +
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKT 541
Query: 506 LETEQRLSKERIRELQQQIEDLQKSLQEQGSKSE---------------------GESSS 544
+ET + S+ +I+ L+Q+ E L +++ +S+ E+SS
Sbjct: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS 601
Query: 545 KLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMK---- 600
KL K+E ++ + E ++K E E+L+ +++ +++K NEL LQKK ++K
Sbjct: 602 KL-SKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKENEL---LQKKITNLKITCE 656
Query: 601 ---AME------ERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILE 649
A+E ER L+K + K L +L E L ++ E R +E L+
Sbjct: 657 KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK 714
Score = 94.0 bits (232), Expect = 4e-19
Identities = 115/583 (19%), Positives = 265/583 (45%), Gaps = 69/583 (11%)
Query: 136 EHIQNIMTLEESVQHVVMTAIQELMSKEILS-SPPNDAVGELEQQLKRALEELQEALAEK 194
E I L E+ Q + + EL S +L N ++ + ++L+ ++ ++ ++
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI 493
Query: 195 EELRQRCEELDMQVTTLQDE----KNSLVS----ENEMMNEKLDQLDGSFDDPNTVVAKK 246
++ + + L +V L++E K SL + ++M EK QL+ + +
Sbjct: 494 LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA-QLEKTIETLRE----- 547
Query: 247 YFHAQLQLEQLQEENFRLEAAKDDYRVHCE----------ELEKQLIE--FQHRNDELTS 294
+++ Q++ L++EN L R + E E +++ + + +L+
Sbjct: 548 --NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 605
Query: 295 LAEETRALKDEIDVLRATSDKANKLESTV-------EIYRQKLQDLNDLRKQVKTLQETN 347
+ E R +K E++ + ++A +LE+ + E+ ++K+ +L ++++ L++ N
Sbjct: 606 IEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN 665
Query: 348 MMYMHNTVSLEEELKKANAARTQLETYKR---QVQDLHVKLSSESKRADTLAFEMKRLEE 404
L++ L QLE+ ++ Q+ + +++L + + +M +L+
Sbjct: 666 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 405 KHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYR 464
+++ L EKE+L + + LK + ++ +V L+ + K+ EN +I +E
Sbjct: 726 ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
Query: 465 EVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQI 524
+ ++++ L++ ++R+E+L+++ + ++ ++LE +++ ++ + L+QQ
Sbjct: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 525 EDLQKSLQEQG-------------SKSEG---ESSSKLKQKLEAHMEKLTEVHEELQKKQ 568
E +L+E SK G ES +LK+ + + E + +++
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 569 ELIEDLQPD------INQNVQKI-NELEAALQKKD---EDMKAMEERYKMYLEKARNVIK 618
L EDL + +N +++K+ +ELE K+ D ++ ++RYK+ K +
Sbjct: 906 TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES--- 962
Query: 619 TLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYE 661
TL L +I L +L E + L E K K ++YE
Sbjct: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK-KNYE 1004
Score = 84.7 bits (208), Expect = 3e-16
Identities = 100/479 (20%), Positives = 208/479 (43%), Gaps = 55/479 (11%)
Query: 175 ELEQQ-LKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLD 233
E+E Q L++ LEEL+ + E+L + + L+ + + L+ +K L EN+ + ++ + D
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 234 GSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELT 293
+ ++ N +++ L++EN L Y+ C L+ E + N EL
Sbjct: 850 TTLEENN-----------VKIGNLEKENKTLSKEIGIYKESCVRLK----ELEKENKEL- 893
Query: 294 SLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKL---QDLNDLRKQVKTLQETNM-- 348
V RAT D + ++ +KL Q NDL K L++ +
Sbjct: 894 --------------VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 349 -MYMHNTVSLEE-----ELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRL 402
+H+ S ++ E K + + LE + ++ L +L + L E+K +
Sbjct: 940 ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV 999
Query: 403 EEKHEAL--LKEKERLIEQRDTL--KETNEELRCSQVQQDHLNQTDASATKSYENLAAEI 458
++ +EAL +++ER+++ + ++ E + ++ L D N +
Sbjct: 1000 KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQA 1059
Query: 459 MPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIR 518
+ +L+ +N L+ Q + + + LQEQ + +L+ E +
Sbjct: 1060 EKQALKTQLKQLETQNNNLQAQILALQRQTV-SLQEQNTTLQTQNAKLQVENSTLNSQST 1118
Query: 519 ELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQ-PD 577
L Q + Q +Q+ ++E ES K ++ L++ + L + HE+L EL+ + Q +
Sbjct: 1119 SLMNQ--NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL----ELLHERQASE 1172
Query: 578 INQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRK 636
+ K L++A + + + + +E+RY L K + ++ L+ L +++L K
Sbjct: 1173 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLL-KQKGQLEDLEKMLKVEQEKMLLENK 1230
Score = 76.3 bits (186), Expect = 1e-13
Identities = 96/458 (20%), Positives = 195/458 (42%), Gaps = 42/458 (9%)
Query: 135 QEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEK 194
Q+ Q + T++++ + + +E M + SSPP + + + E QE E
Sbjct: 990 QQLRQELKTVKKNYEALKQRQDEERM---VQSSPP------ISGEDNKWERESQETTREL 1040
Query: 195 EELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQL 254
+++ R E++ TLQ EK +L ++ L QL+ N + + Q Q
Sbjct: 1041 LKVKDRLIEVERNNATLQAEKQALKTQ-------LKQLETQ----NNNLQAQILALQRQT 1089
Query: 255 EQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDEL----TSLAEETRALKDEIDVLR 310
LQE+N L+ +V L Q ++N +L +SL E ++ E + L+
Sbjct: 1090 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1149
Query: 311 ATSDKANKLESTVEI-YRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAART 369
+ D K +E+ + ++ + L + TL+ + LE+ + +
Sbjct: 1150 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1209
Query: 370 QLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEE 429
QLE ++ ++ K+ E+K +T+A E K+L +++ L +L+++ + L+ ++
Sbjct: 1210 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1269
Query: 430 LRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERI 489
L+ S + L QT A + L + ++ + Q E L Q +G+ E
Sbjct: 1270 LK-SLLNNSKLEQTRLEA--EFSKLKEQYQQLDITSTKLNNQCE---LLSQLKGNLEEEN 1323
Query: 490 EELQEQ-----------LEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKS 538
L +Q LEQ + EQR +++ EL++Q E L++ + +Q
Sbjct: 1324 RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFY 1383
Query: 539 EGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQP 576
+ + + M KL + +++ ++++ L P
Sbjct: 1384 DPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTP 1421
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 150 bits (378), Expect = 5e-36
Identities = 176/743 (23%), Positives = 341/743 (45%), Gaps = 90/743 (12%)
Query: 11 KLPLCDSLMIWLQTFNT-ASPCQD----VKQLTSGVAMAQVLHQIDAAWFNESWLSRIKE 65
+L L L+ W++TF S QD L G+ + Q++ QID N+ RI +
Sbjct: 10 ELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQ----RINK 65
Query: 66 DVGDNWRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPV------ELGR 119
V ++ ++ N+ +++ I +YY E L QQ+ +P++ I DP+ E+ +
Sbjct: 66 HVNNDVNLRIQNLTILVRNIKTYYQEVL-QQLIVMNLPNVLMIGR--DPLSGKSMEEIKK 122
Query: 120 LLQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEI------LSSPPNDAV 173
+L L+LGCA+ CE+K+E I+ I L+ Q ++ IQE+ + P+ A
Sbjct: 123 VLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAP 182
Query: 174 GELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLD 233
ELE + + L+ + +++E C EL + L E++ L +++ K D
Sbjct: 183 EELEALSRSMVLHLRRLIDQRDE----CTEL---IVDLTQERDYLQAQHPPSPIKSSSAD 235
Query: 234 GSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDY-------RVHCEELEKQLIEFQ 286
+ +++ ++ H ++L + R+ +D R ++L +L + +
Sbjct: 236 STPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVK 295
Query: 287 HRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQET 346
N +L + A RA +DE+D LR +++ +LE + ++KL D++ + +++ L+E
Sbjct: 296 QENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELRED 355
Query: 347 NMMYMHNTVSLEEELKKANAARTQLE-------TYKRQVQDLHVKLSSESKRADTLAFEM 399
N++ + LEE+L A A ++ K ++ DL + ++ KR + L E
Sbjct: 356 NIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEEN 415
Query: 400 KRLEEKHEALLKEKERL---IEQRDTLKETNEELRCSQVQQDHLNQTDASATKSY--ENL 454
LE + + E L +EQ + ++ R S V + LN+ +S EN
Sbjct: 416 MVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFE--LNECASSRILKLEKENQ 473
Query: 455 AAEIMPVEYREVFIRLQHEN-KMLRLQQEGSE-NERIEELQEQLEQKHRKMNELETEQRL 512
+ + R+ + L+ K L++E + +++IE+LQ QLE++ + +LET L
Sbjct: 474 SLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLET---L 530
Query: 513 SKERIRELQQ--------------QIEDLQK----------SLQEQGSKSEGESSSKLKQ 548
S+E IRE +Q QI+DL++ SL+E+ S +++
Sbjct: 531 SEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEK 590
Query: 549 KLEAHMEKLTEVHEELQ----KKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEE 604
+ +A + +TE + +L +K++L DL+ + ++ +LE LQ+ E+ +
Sbjct: 591 ENKALHQTVTEANGKLSQLEFEKRQLHRDLE-QAKEKGERAEKLERELQRLQEENGRLAR 649
Query: 605 RYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKER---RIEILESECKVAKFRDYE 661
+ LE A ++ L+ + E LRK L + ++E LE + K + E
Sbjct: 650 KVTS-LETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLE 708
Query: 662 EKLIVSAWYNKSLAFQKLGMESR 684
+ +V S ++ E++
Sbjct: 709 LRRLVETMRFTSTKLAQMERENQ 731
Score = 87.0 bits (214), Expect = 5e-17
Identities = 132/588 (22%), Positives = 250/588 (42%), Gaps = 64/588 (10%)
Query: 95 QQISEALIPDLNQITECSDPVELGRLLQLILGCAINCEKKQEHIQNIMTLEESVQHVVMT 154
+ +SE LI + Q+ + ++ + Q+ + E++++H+ M V
Sbjct: 528 ETLSEELIREKEQLQSDMETLKADKARQIK-----DLEQEKDHLNRAMWSLRERSQVSSE 582
Query: 155 AIQELMSKE--ILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQ 212
A + + KE L +A G+L Q L+ +L L + +E +R E+L+ ++ LQ
Sbjct: 583 ARMKDVEKENKALHQTVTEANGKLSQ-LEFEKRQLHRDLEQAKEKGERAEKLERELQRLQ 641
Query: 213 DEKNSL---VSENEMMNEKLDQLDGSFDD---PNTVVAKKYFHAQ---LQLEQLQEENFR 263
+E L V+ E EK++ L+ N + K Q LQLE L+ +N +
Sbjct: 642 EENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQ 701
Query: 264 LEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTV 323
L+A + R E + + E L E L+ +D+L+A K+ +LE +
Sbjct: 702 LDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSY 761
Query: 324 EIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHV 383
+ + + LQ++ H T +LE EL + A R L ++ +
Sbjct: 762 Q----------SVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANA 811
Query: 384 KLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRD----TLKETNEELRCSQVQQDH 439
+L K L E+ +LE+ + L KE +RL +Q + L ++ +L + +
Sbjct: 812 QLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRA 871
Query: 440 LNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQK 499
L++ A + L L+ +N+ L +Q + L+E L +
Sbjct: 872 LDKELARCRDAAGKLK-------------ELEKDNRDL-TKQVTVHARTLTTLREDLVLE 917
Query: 500 HRKMNELETE-QRLSKERIRELQQQIEDLQKSLQEQGSKS-------EGESSSKLKQKLE 551
K +L +E +LS +EL++ + + LQE S S EG + S LK L
Sbjct: 918 KLKSQQLSSELDKLS----QELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLA 973
Query: 552 AHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLE 611
EK+ + ++++K L L+ ++ Q ++K E E Q + E + ++ +K
Sbjct: 974 MKEEKIVLLEAQMEEKASLNRQLESEL-QMLKK--ECETLRQNQGEG-QHLQNSFKHPAG 1029
Query: 612 K---ARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAK 656
K + + P A+ E++ ++ + E ER L++E ++ K
Sbjct: 1030 KTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLK 1077
Score = 62.4 bits (150), Expect = 1e-09
Identities = 102/463 (22%), Positives = 179/463 (38%), Gaps = 75/463 (16%)
Query: 187 LQEALAEKEE----LRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQ---LDGSFDDP 239
L+ LA KEE L + EE L+ E L E E + + + L SF P
Sbjct: 968 LKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHP 1027
Query: 240 NTVVAKKYF--------HAQLQLE---------QLQEENFRLEAAKDDYRVHCEELEKQL 282
A + H + +E +L+ N L+A K + + LE Q
Sbjct: 1028 AGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQN 1087
Query: 283 IEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKT 342
+ F + ++ +L +++ L++ L+ + K ST+ L L + T
Sbjct: 1088 VTF---SSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHT 1144
Query: 343 LQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRA---------- 392
+ET SL+ + ++ AA L + LH + S+E +
Sbjct: 1145 AKETE------NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTL 1198
Query: 393 -DTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSY 451
L E K L E+H +LK K L E+ L E L+ Q +T+A A
Sbjct: 1199 HRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQ-------RTNALAMGEN 1251
Query: 452 ENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQR 511
+ L E+ V + L H+ K EEL ++ +N + E
Sbjct: 1252 QRLRGELDRVNF------LHHQLK-----------GEYEELHAHTKELKTSLNNAQLELN 1294
Query: 512 LSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELI 571
+ R EL++Q + + SL + + E S+LK LE L + L ++ +++
Sbjct: 1295 RWQARFDELKEQHQTMDISLTKLDNHC--ELLSRLKGNLEEENHHLLSQIQLLSQQNQML 1352
Query: 572 -----EDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMY 609
E+ + + Q I++L A + K++ + + ++YK Y
Sbjct: 1353 LEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFY 1395
Score = 33.1 bits (74), Expect = 0.94
Identities = 32/139 (23%), Positives = 61/139 (43%), Gaps = 12/139 (8%)
Query: 171 DAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLD 230
D V L QLK EEL A +EL+ +++ Q + L +++ M+ L
Sbjct: 1259 DRVNFLHHQLKGEYEELH---AHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLT 1315
Query: 231 QLDGSFDDPNTV---VAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQH 287
+LD + + + + ++ H Q++ L ++N L + + E +KQ I
Sbjct: 1316 KLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYI---- 1371
Query: 288 RNDELTSLAEETRALKDEI 306
D+L +L L+++I
Sbjct: 1372 --DKLNALRRHKEKLEEKI 1388
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 107 bits (267), Expect = 4e-23
Identities = 96/437 (21%), Positives = 212/437 (48%), Gaps = 34/437 (7%)
Query: 178 QQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFD 237
++LKR LE + L +++L+ + L ++ ++ + + V ENE+ N Q +
Sbjct: 306 KELKRKLERAK-LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMW 364
Query: 238 DPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAE 297
+ + Q Q E+++E+ ++ ++ R EE+ + E R +E+ E
Sbjct: 365 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ-EEMMWEKEEKMRRQEEMMWEKE 423
Query: 298 ETRALKDEI-----DVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMH 352
E ++E+ + +R +K ++ E E +K Q+ +R+Q K ++ M+
Sbjct: 424 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE-QEEKRQEEEKIREQEKRQEQEAKMWRQ 482
Query: 353 NTVSLEEELKKANAARTQLETYKRQVQDLHV--KLSSESKRADTLAFEMKRLEEK---HE 407
E+E K R Q E RQ + +H K+ E KR + EM R EEK E
Sbjct: 483 EEKIREQEEK----IREQEEKMWRQEEKIHEQEKIREEEKRQEQE--EMWRQEEKIREQE 536
Query: 408 ALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVF 467
+ ++KE++ EQ + +++ E++ Q++ ++ + + E + + + +E
Sbjct: 537 EIWRQKEKIHEQEEKIRKQEEKM---WRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEK 593
Query: 468 IRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDL 527
IR Q E + + + E++ E +E++ ++ KM E E + R +E+IRE +++I +
Sbjct: 594 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ 653
Query: 528 QKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINE 587
++ ++EQ ++ ++ EK+ E E++ +++E +++ + + + +K+ E
Sbjct: 654 EEKIREQ------------EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 701
Query: 588 LEAALQKKDEDMKAMEE 604
E L++++E M+ +E
Sbjct: 702 QEVRLRQQEEKMQEHQE 718
Score = 102 bits (253), Expect = 2e-21
Identities = 110/543 (20%), Positives = 261/543 (48%), Gaps = 52/543 (9%)
Query: 135 QEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEK 194
Q H I+T +++ + + Q + + L D + L K A EL++AL+
Sbjct: 189 QVHTIRILTCQKTELQMALYYSQHAVKQ--LEGEARDLISRLHDSWKFA-GELEQALSAV 245
Query: 195 EELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQL 254
+++ + ++T +D + + N + +E+L + + + +V + QL +
Sbjct: 246 ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV 305
Query: 255 EQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATS- 313
++L+ +LE AK + ++L+ E H EL S++ + +A +E ++ +
Sbjct: 306 KELKR---KLERAK--LLLPQQQLQA---EADHLGKELQSVSAKLQAQVEENELWNRLNQ 357
Query: 314 ---DKANKLESTVEIYRQKLQDLND-LRKQVKTLQETNMMYMHNTVSLEEELKKANAART 369
+K + E ++ + +K+Q+ + +R+Q + ++E EE++++
Sbjct: 358 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ-----------EEKMRRQEEMMW 406
Query: 370 QLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEE 429
+ E R+ +++ + + +R + + +E + + E + E+E++ EQ + +E E+
Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE-EEK 465
Query: 430 LRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERI 489
+R +Q+ + +A + E + + E IR Q E KM R +++ E E+I
Sbjct: 466 IR----EQEKRQEQEAKMWRQEEKIREQ-------EEKIREQEE-KMWRQEEKIHEQEKI 513
Query: 490 EELQEQLEQKH--RKMNELETEQRL--SKERIRELQQQIEDLQKSL--QEQGSKSEGESS 543
E +++ EQ+ R+ ++ ++ + KE+I E +++I ++ + QE+ + E
Sbjct: 514 REEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKI 573
Query: 544 SKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAME 603
+ ++K+ EK+ E E++++++E I + + + +K+ E E + +++E M+ E
Sbjct: 574 REQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 633
Query: 604 ERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRI-EILESEC-KVAKFRDYE 661
E+ + EK I+ + K+ +I + + E+E ++ E E C + K ++ E
Sbjct: 634 EKMRRQEEK----IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 689
Query: 662 EKL 664
EK+
Sbjct: 690 EKM 692
Score = 101 bits (251), Expect = 3e-21
Identities = 99/471 (21%), Positives = 226/471 (47%), Gaps = 40/471 (8%)
Query: 174 GELEQQLKRALEELQEALAEKEELRQRCEELDMQV--TTLQDEKNSLVSENEMMNEKLDQ 231
GELEQ L + ++A EEL + + L +++ T+ DE+ L +N + EKL
Sbjct: 236 GELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE--LKEKNAKLQEKLQL 293
Query: 232 LDGSFDDPNTVVA---KKYFHAQLQLEQ-------------LQEENFRLEAAKDDY---- 271
++ + V +K A+L L Q LQ + +L+A ++
Sbjct: 294 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 353
Query: 272 RVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQ 331
R++ ++ EK + + + + E+ ++++ + +R +K + E + +K++
Sbjct: 354 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 413
Query: 332 DLNDL--RKQVKTLQETNMMYMHNTV--SLEEELKKANAARTQLETYKRQVQDLHVKLSS 387
++ K+ K ++ MM+ LEE++ + R Q E KRQ ++ K+
Sbjct: 414 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE--KRQEEE---KIRE 468
Query: 388 ESKRADTLAF---EMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQ-T 443
+ KR + A + +++ E+ E + +++E++ Q + + E E++R + +Q+
Sbjct: 469 QEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE-QEKIREEEKRQEQEEMWR 527
Query: 444 DASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKM 503
+ E + + + +E IR Q E + ++ + E+I E +E++ ++ K+
Sbjct: 528 QEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKI 587
Query: 504 NELETEQRLSKERIRELQQQIEDLQKSLQEQGSK--SEGESSSKLKQKLEAHMEKLTEVH 561
E E + R +E+IRE ++ ++ ++ + EQ K + E + ++K+ EK+ E
Sbjct: 588 REQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQE 647
Query: 562 EELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEK 612
+++++++E I + + + + +K+ E E + +++E M+ EE+ + EK
Sbjct: 648 KKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 698
Score = 74.7 bits (182), Expect = 3e-13
Identities = 69/370 (18%), Positives = 174/370 (47%), Gaps = 41/370 (11%)
Query: 178 QQLKRALEELQEALAEKEE-LRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSF 236
Q+ + ++E +E + E+EE +R++ E++ Q + +++ + + EMM EK +++
Sbjct: 371 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ- 429
Query: 237 DDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLA 296
+ + + ++ +L+E+ E ++ EE +++ E + R ++ +
Sbjct: 430 -------EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE--EKIREQEKRQEQEAKMW 480
Query: 297 EETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVS 356
+ ++++ + +R +K + E +K+ + +R++ K ++ M +
Sbjct: 481 RQEEKIREQEEKIREQEEKMWRQE-------EKIHEQEKIREEEKRQEQEEMWRQEEKIR 533
Query: 357 LEEEL--------KKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEA 408
+EE+ ++ R Q E RQ + +H + ++ + + + +++ E+ E
Sbjct: 534 EQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEK 593
Query: 409 LLKEKERLIEQRDTLKETNEELRCSQV----QQDHLNQTDASATKSYENLAAEIMPVEYR 464
+ +++E++ EQ + +E E++ + Q++ + + + + E + + + +
Sbjct: 594 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ 653
Query: 465 EVFIRLQHE------NKMLRLQQEGSENERIEELQEQLEQKHR---KMNELETEQRLSKE 515
E IR Q E KM +++ E E E++QEQ E+ R KM E E R +E
Sbjct: 654 EEKIREQEEMMQEQEEKMWEQEEKMCEQE--EKMQEQEEKMRRQEEKMWEQEVRLRQQEE 711
Query: 516 RIRELQQQIE 525
+++E Q+ +E
Sbjct: 712 KMQEHQEHLE 721
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/154 (19%), Positives = 78/154 (50%), Gaps = 9/154 (5%)
Query: 132 EKKQEHIQNIMTLEESV---QHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQ 188
EK +E + + EE + + + +++ +E ++ + +GE E+++ E++Q
Sbjct: 571 EKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ 630
Query: 189 EALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMM---NEKLDQLDGSFDDPNTVVAK 245
E ++E++R++ E++ Q +++++ + + EMM EK+ + + + + +
Sbjct: 631 E---QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 687
Query: 246 KYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELE 279
+ + Q E++ E+ RL ++ + H E LE
Sbjct: 688 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 106 bits (265), Expect = 7e-23
Identities = 112/515 (21%), Positives = 236/515 (45%), Gaps = 44/515 (8%)
Query: 174 GELEQQLKRALEEL----QEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKL 229
GE Q+LK L E+ Q AE ++L+Q+ EE + LQ E N L S+ +L
Sbjct: 371 GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL 430
Query: 230 DQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRN 289
+ G + + ++K + Q+ LQ + RLE + + EL+ QL + + ++
Sbjct: 431 GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH 490
Query: 290 DELTSLAEET-----RALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQ 344
E +L + T A D VLR DK K+++ + ++ ++++ L K+ + L
Sbjct: 491 QEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLY 550
Query: 345 ETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEM-KRLE 403
+ E E N + + T + QV L KL ++S+ + +++
Sbjct: 551 A-------KIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603
Query: 404 EKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEY 463
E+ L ++R++ ++ E N +L S+ + L+ + T+ L+AE
Sbjct: 604 EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELL--LSAEAAKTAQ 661
Query: 464 REVFIRLQH-----ENKMLRLQQEGSE-NERIEELQEQLEQKHRKMNELETEQRLSKERI 517
R LQ+ +N + QQE ++ +++++ +L+ K ++LE+ + KE+
Sbjct: 662 R---ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKY 718
Query: 518 RELQQQIEDLQ--------KSLQEQGSKSEGESSSKLKQKLEAHME-KLTEVHEELQKKQ 568
L+Q+ E+L+ SL+ + SK + + +++L +E + TE+ ++L+ ++
Sbjct: 719 LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK 778
Query: 569 ELIEDLQPDINQNVQKINELEAALQKKDE-------DMKAMEERYKMYLEKARNVIKTLD 621
E++ + D+ + + + ++ L K++E D + + + K+ E+ N I+T
Sbjct: 779 EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTV 838
Query: 622 PKLNPASAEIMLLRKQLAEKERRIEILESECKVAK 656
+L E L +L+ + ++ + K +K
Sbjct: 839 TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK 873
Score = 104 bits (259), Expect = 3e-22
Identities = 145/667 (21%), Positives = 295/667 (44%), Gaps = 83/667 (12%)
Query: 45 QVLHQIDAAWFNESW--LSRIKEDVGDNWRIKASNVKKVLQ------GIMSYYHEFLGQQ 96
Q L Q A E+ L ++ +GD + K N++ +LQ ++ E L +
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQ-KIQNLEALLQKSKENISLLEKEREDLYAK 552
Query: 97 IS--EALIPDLNQITECSDPVE--LGRLLQLILGCAINCEKKQEHIQNIMTLEESVQHV- 151
I E LNQ+ E + ++ + +L + + + + ++ QE++ + ++E H+
Sbjct: 553 IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD--QVQEQKAHLR 610
Query: 152 --------VMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEE 203
+ T++ EL S+ + + V +L+ Q+K E L A A K R +
Sbjct: 611 AAQDRVLSLETSVNELNSQ---LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667
Query: 204 -LDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENF 262
LD LQD++ L + +LDQ+ D ++ H L++ +E+
Sbjct: 668 HLDTAQNALQDKQQEL----NKITTQLDQVTAKLQDKQEHCSQLESH----LKEYKEKYL 719
Query: 263 RLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLEST 322
LE ++ ++LE +E + ++ ++ R L +++ LRAT + + +LE
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLE-LRAT-ELSKQLEME 777
Query: 323 VEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLH 382
EI DL + ++++++ L ++ ++ + ET ++ + H
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQ----------KLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 383 VKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQ 442
+L++ R T E+++++ + EAL+ E L +D L + ++ L+ S+ + + NQ
Sbjct: 828 EELNN---RIQTTVTELQKVKMEKEALMTE---LSTVKDKLSKVSDSLKNSKSEFEKENQ 881
Query: 443 TDASATKSYENLAAEI---MPVEYREVFIRLQHENKMLRLQQEGSENERIE--ELQEQLE 497
+A E E+ + V+ + K L ++E S ++E +QEQL
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLI 941
Query: 498 QKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAH---M 554
Q + + E E++ + I EL+Q E +K ++ +GE + QK E
Sbjct: 942 QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL----QGELKIAVLQKTELENKLQ 997
Query: 555 EKLTEVHEELQKKQELIEDLQPDINQNVQKINEL-------EAALQKKDEDMKAMEERYK 607
++LT+ +EL ++E I LQ + ++ + +L E+ L +D+K++EE+
Sbjct: 998 QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLS 1057
Query: 608 MYLE---KARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECK----VAKFRDY 660
+ E RN I + + L + A+KE++ L+ CK + K +
Sbjct: 1058 LAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQ---LQERCKALQDIQKEKSL 1114
Query: 661 EEKLIVS 667
+EK +V+
Sbjct: 1115 KEKELVN 1121
Score = 96.7 bits (239), Expect = 7e-20
Identities = 127/532 (23%), Positives = 241/532 (45%), Gaps = 108/532 (20%)
Query: 180 LKRALEELQEALAEK----EELRQRCEELDMQVTTLQDEK-NSLVSENEMMNEKLDQLDG 234
L++ +++LQ +L E+ EEL++ E+ Q Q+ K + LV+++ + L+Q
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKY--QGLQQQEAKPDGLVTDSSAELQSLEQ--- 142
Query: 235 SFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTS 294
QLE+ Q ENF ++ KD + +L ++ + + + DE S
Sbjct: 143 ------------------QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERS 184
Query: 295 LAEETRALKDEIDVLRATSDKANKLESTVE------IYRQKLQDLNDLRK---QVKTLQE 345
L E E V R T ++ NK + ++ + R ++D+ L+K QV+TL +
Sbjct: 185 LREAA-----EQKVTRLT-EELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMD 238
Query: 346 T-NMMYMHNTVSLEEELKK-------ANAARTQLET-----------YKRQVQDLHVKLS 386
+ + L++E KK + A +QL + Y +++Q L ++
Sbjct: 239 NMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVN 298
Query: 387 SESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKET--NEELRCSQVQQDHLNQTD 444
+++ TL + + E+ + L ++ + ++ T ++L C Q+ Q L+ ++
Sbjct: 299 ELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL-QSRLSASE 357
Query: 445 ASATKSYENL-----AAEIMPVEYREVFIRLQH---ENKMLRLQQEGSENERIEELQEQL 496
S + + L A + + E EV + QH E K L+ Q+E E + +LQ ++
Sbjct: 358 TSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGL-QLQSEI 416
Query: 497 EQKHRKMNE-----------LETEQRLSKERIRELQQQIEDLQKSLQ--EQGSKSEGESS 543
Q H K+ E L+ +++LS E++ + +QQ+ DLQ L E+ K + +S
Sbjct: 417 NQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNS 476
Query: 544 SKLKQKLEAHMEKLTEVHEE-----------LQKKQELIEDLQPDINQNVQKINELEAAL 592
++L+ +L +K + H+E L++ Q +E + I QKI LEA L
Sbjct: 477 TELQHQL----DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
Query: 593 QKKDEDMKAME-ERYKMYL-----EKARNVIKTLDPKLNPASAEIMLLRKQL 638
QK E++ +E ER +Y E V+ L K + ++ L ++L
Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL 584
Score = 92.4 bits (228), Expect = 1e-18
Identities = 129/589 (21%), Positives = 251/589 (42%), Gaps = 82/589 (13%)
Query: 122 QLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLK 181
Q + + + +E ++ +T +QH + Q+ ++ L + E + L+
Sbjct: 453 QQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE 512
Query: 182 RALEELQ---------EALAEKEE-----LRQRCEELDMQVTTLQDEK---NSLVSENEM 224
+ L ++ EAL +K + L + E+L ++ + E N L +N
Sbjct: 513 QVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHT 572
Query: 225 MNEKLDQLDGSFDDPNTVVAKKYFHAQLQL-EQLQEENFRLEAAKD---DYRVHCEELEK 280
+ E++ QL + + + + AQ L +Q+QE+ L AA+D EL
Sbjct: 573 LQEQVTQLTEKLKNQS----ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
Query: 281 QLIEFQHR----------NDELTSLAEETRA-----LKDEIDVLR-ATSDKA---NKLES 321
QL E + + EL AE + L++ +D + A DK NK+ +
Sbjct: 629 QLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
Query: 322 TVEIYRQKLQDLND----LRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQ 377
++ KLQD + L +K +E + T LE ++KK A +++ K Q
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 378 -VQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQ 436
+QDL + +R E+ R E + L EKE + R L++ +E L + +
Sbjct: 749 ALQDL------QQQRQLNTDLEL-RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
Query: 437 QDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERI------- 489
+ + +E L+ E +++ E+ R+Q + LQ+ E E +
Sbjct: 802 LTKQEEEKQILKQDFETLSQETK-IQHEELNNRIQ--TTVTELQKVKMEKEALMTELSTV 858
Query: 490 -EELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQ 548
++L + + +E E E + K I +L++ ++L+ LQ Q + E +LK+
Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK-ELKK 917
Query: 549 KLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQK-------INELEAALQKKDEDMKA 601
LE E ++ EL QE + Q + QN ++ INEL+ + ++K + ++A
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEA 977
Query: 602 MEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILES 650
++ K+ + + + L +L A+ E LA ++ +I +L++
Sbjct: 978 LQGELKIAVLQKTELENKLQQQLTQAAQE-------LAAEKEKISVLQN 1019
Score = 89.4 bits (220), Expect = 1e-17
Identities = 110/571 (19%), Positives = 248/571 (43%), Gaps = 46/571 (8%)
Query: 141 IMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQR 200
+ +LE+ ++ K++ E+ + EE A ++++ +
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196
Query: 201 CEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEE 260
EEL+ + T +QD K L+ + E + L T++ + + E+L++E
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGI--EDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 261 NFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLE 320
+L++ +L +L + E+ +E + LK ++ L K +
Sbjct: 255 CKKLQSQYASSEATISQLRSELAK---GPQEVAVYVQELQKLKSSVNEL------TQKNQ 305
Query: 321 STVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQD 380
+ E +K QD L ++ E ++ + +L ++ +++L + +
Sbjct: 306 TLTENLLKKEQDYTKLEEK---HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 381 LHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDH- 439
+HV+LS + + L E+ +E K++ L E ++L +QR+ ++ +L+ S++ Q H
Sbjct: 363 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQ-SEINQLHS 421
Query: 440 -LNQTDASATKSYENL-------AAEIMPVEYREVFIRLQHENKMLRLQQEGSEN-ERIE 490
L +T+ +++ L + ++M E + ++L K+ RL+++ E
Sbjct: 422 KLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL----KLSRLEEQLKEKVTNST 477
Query: 491 ELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKL 550
ELQ QL++ ++ E + Q+ + ++RE Q +E + + + ++ K ++ L QK
Sbjct: 478 ELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI--QNLEALLQKS 535
Query: 551 EAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYL 610
+ ++ L + E+L K + E +NQ +K + L+ + + E +K E +K
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 611 EKARNVIKTLDPKLNPASAEIML-------LRKQLAEKERRIEILESECKVAKFRDYEEK 663
E + ++ L A ++ L QL E + ++ L+ + K + +
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA------KTE 649
Query: 664 LIVSAWYNKSLAFQKLGMESRLVSGGGACSD 694
L++SA K+ Q+ +++ L + A D
Sbjct: 650 LLLSAEAAKTA--QRADLQNHLDTAQNALQD 678
Score = 85.9 bits (211), Expect = 1e-16
Identities = 110/524 (20%), Positives = 238/524 (45%), Gaps = 44/524 (8%)
Query: 99 EALIPDLNQITECSDPVELGRLLQLILGCAINCEKK-QEHIQNIMTLEES---VQHVVMT 154
EAL+ +L+ + + +L ++ + EK+ Q+ I+ LE++ ++H +
Sbjct: 849 EALMTELSTVKD-----KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
Query: 155 AIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDE 214
++ + ++ + E QLK L +QE L + + ++ E+ + Q LQ
Sbjct: 904 QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ---LQGN 960
Query: 215 KNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQ------LEQLQEENFRLEAAK 268
N L +E ++++ L G V+ K +LQ ++L E ++ +
Sbjct: 961 INELKQSSEQKKKQIEALQGELKI--AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 269 DDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEI-----DVLRATSDKANKLESTV 323
++Y E ++ +F R EL + ++ +++++++ D++ + N+ +
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 324 EIYRQKLQDLNDLRKQVKTLQET--NMMYMHNTVSLEE-ELKKANAARTQLETYKRQVQD 380
E+ K D K+ + LQE + + SL+E EL + ++E K + +
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138
Query: 381 LHVKLSSESKRADTLAF-EMKRLEEKHEALLKEKERLIEQRDTLKETNE-ELRCSQVQQD 438
KL+ E K + E+ L++ + L+++K L + D+LK E E R Q+ +D
Sbjct: 1139 EITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD 1198
Query: 439 HLNQTDASATKSYENLAAEI-MPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLE 497
+ + + K + A++ ++ +EV ++ EN+ Q + NE + ++++ +
Sbjct: 1199 QVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQ 1258
Query: 498 QKHRKMNELETEQRLSKERIRELQ---QQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHM 554
R+++ELE + + I L+ Q +D +++L E+ K EGE +E
Sbjct: 1259 SSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGE--------IEKLQ 1310
Query: 555 EKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDED 598
K+ E+ +L +++L + NQ++Q I +A +K ED
Sbjct: 1311 TKVLELQRKLDNTTAAVQELGRE-NQSLQ-IKHTQALNRKWAED 1352
Score = 62.8 bits (151), Expect = 1e-09
Identities = 86/434 (19%), Positives = 182/434 (41%), Gaps = 50/434 (11%)
Query: 257 LQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDE-------LTSLAEETRALKDEIDVL 309
L++E L+A+ + + + EEL+K+L ++Q + +T + E ++L+ +++
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147
Query: 310 RATSDKANKLESTVEIYRQKLQ-DLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAAR 368
+ + +++ E +L ++ D++ + + L EEL K
Sbjct: 148 QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVI 207
Query: 369 TQLETYKRQ---VQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKE 425
L+T Q ++D+ V L E + TL M E+ LK++
Sbjct: 208 QDLKTELLQRPGIEDVAV-LKKELVQVQTLMDNMTLERERESEKLKDE------------ 254
Query: 426 TNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSE 485
C ++Q + AS+ + L +E+ +EV + +Q K+ E ++
Sbjct: 255 ------CKKLQSQY-----ASSEATISQLRSELAKGP-QEVAVYVQELQKLKSSVNELTQ 302
Query: 486 -NERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSE----- 539
N+ + E + EQ + K+ E E+ +SK+ I+ Q + + LQ + S SE
Sbjct: 303 KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 540 --------GESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAA 591
GE++ KLK++L K + E ++ Q+ E+ + Q +IN+L +
Sbjct: 363 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 592 LQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESE 651
L + + + R K + + + + ++ ++ L +QL EK L+ +
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Query: 652 CKVAKFRDYEEKLI 665
K + E++ +
Sbjct: 483 LDKTKQQHQEQQAL 496
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 105 bits (262), Expect = 1e-22
Identities = 139/601 (23%), Positives = 264/601 (43%), Gaps = 89/601 (14%)
Query: 150 HVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVT 209
++V IQ L S+ S+ N+ ++K LE+ + E EL++ +L ++V
Sbjct: 579 NLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQR---QLQLEVK 635
Query: 210 TLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKD 269
Q+ K E E M L++L ++ ++E+ RLE ++
Sbjct: 636 NQQNIKE----ERERMRANLEELRSQHNE--------------KVEENSTLQQRLEESEG 677
Query: 270 DYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQK 329
+ R + EEL + +E + E+ L ++ + DE+D + + D+ + + +E Q
Sbjct: 678 ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDR--EKGALIEELLQA 735
Query: 330 LQDLNDL----RKQVKTLQETNMMYMHNTVSLEEELKKANAARTQL-ETYKRQVQDLHVK 384
QDL DL +Q L++ +L+EE+ + +L E Y ++Q L
Sbjct: 736 KQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRES 795
Query: 385 LSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEEL--RCSQVQQ--DHL 440
+ +K + LA E+ + L E+ + L+ +EEL R +Q+Q+ + L
Sbjct: 796 VEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDL 855
Query: 441 NQTDASATKSYENLAAEIMPVEYREVFIRLQHE------------------NKMLRLQQE 482
+A A ++ + EI +E V R + + N Q++
Sbjct: 856 KGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQ 915
Query: 483 GSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIED-----------LQKSL 531
+E+++E EQ EQ R NE+E E+ + I +LQ+++ D LQ L
Sbjct: 916 KQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQL 975
Query: 532 QEQGSKSE---GESSSKLKQK-LEAHMEKLT--EVHEELQKKQELIEDLQPDINQNVQKI 585
E K+ E +LK+K LEA +LT ++ +E++ +E + D Q ++ + K
Sbjct: 976 DEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKR 1035
Query: 586 N-----------ELEAALQKKDED---MKAMEER---YKMYLEKARNVIKTLDPKLNPAS 628
ELEA KD+ +K ME++ +M LE+ RN L +++ +
Sbjct: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR 1095
Query: 629 AEIMLLRKQLAEKERRIEILESECKVA---KFRDYEEKLI-VSAWYNKSLAFQKLGMESR 684
++ LR +L ++ + LE + K++ + +D + ++I + Y S + ME+R
Sbjct: 1096 EQMEQLRNELLQERAARQDLECD-KISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEAR 1154
Query: 685 L 685
+
Sbjct: 1155 I 1155
Score = 102 bits (253), Expect = 2e-21
Identities = 109/501 (21%), Positives = 226/501 (45%), Gaps = 58/501 (11%)
Query: 134 KQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAE 193
K+++ + L ESV+ E+++ +S + A E+ +L LQE E
Sbjct: 782 KEQYDAELQALRESVEEATKNV--EVLASRSNTSEQDQAGTEMRVKL------LQE---E 830
Query: 194 KEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSF------------DDPNT 241
E+L+ R EEL+ +V LQ + L + E L + +G ++
Sbjct: 831 NEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEA 890
Query: 242 VVAKKYFHAQLQ-----LEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLA 296
V A++ +L+ L Q +E +L + E+L + E ++ L
Sbjct: 891 VSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTI 950
Query: 297 EETRALKDEIDVLRATSDKANKLESTVEIYRQK-LQDLNDLRKQVK--TLQE-----TNM 348
E+ + K+ D++ A+ +L++ ++ Y++K ++L ++++Q+K TL+ T M
Sbjct: 951 EKLQ--KEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAM 1008
Query: 349 MYMHNTVSLEEELKKANAAR----TQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEE 404
+EEEL+ A+ T+ + ++ ++DL +L ++S D + +K++E+
Sbjct: 1009 KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMED 1068
Query: 405 KHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEY- 463
K L E E E+R+ +E + S+ Q + L + ++L + + +E
Sbjct: 1069 KVSQLEMELE---EERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQ 1125
Query: 464 -REVFIRLQHENKMLRLQQEG---SENERIEELQEQLEQKHRKMNELETEQRLSKERIRE 519
+++ R+ H R +EG RI EL+++LE + R L+ R + +++E
Sbjct: 1126 NKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKE 1185
Query: 520 LQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDIN 579
L Q++D SL +Q +L +L+A ++ E EE+ + + + LQ ++
Sbjct: 1186 LVMQVDDEHLSLTDQ--------KDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE 1237
Query: 580 QNVQKINELEAALQKKDEDMK 600
+ + L+ L +D++
Sbjct: 1238 EQMDMNEHLQGQLNSMKKDLR 1258
Score = 58.5 bits (140), Expect = 2e-08
Identities = 54/309 (17%), Positives = 135/309 (43%), Gaps = 16/309 (5%)
Query: 358 EEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFE-MKRLEEKHEALLKEKERL 416
++EL + T + +++ +KR L FE ++ L+ + + +
Sbjct: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQA 602
Query: 417 IEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKM 476
+K+ E+ ++ L + K+ +N+ E + +R QH K+
Sbjct: 603 CNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKV 662
Query: 477 LRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGS 536
++ + +R+EE + +L + ++ +++ E+ + IR+LQ Q+ ++ L +
Sbjct: 663 ---EENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDEL-DSAK 718
Query: 537 KSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKK- 595
+SE L +E+L + ++LQ E+ + + + +++ L+ AL+++
Sbjct: 719 RSEDREKGAL-------IEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEV 771
Query: 596 ---DEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESEC 652
D++M ++E+Y L+ R ++ + ++ + A E R+++L+ E
Sbjct: 772 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEEN 831
Query: 653 KVAKFRDYE 661
+ + R E
Sbjct: 832 EKLQGRSEE 840
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 105 bits (261), Expect = 2e-22
Identities = 138/641 (21%), Positives = 273/641 (42%), Gaps = 92/641 (14%)
Query: 141 IMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQR 200
+M ++E H+ +Q + V +L Q+L+ E+L+ ++ +E RQ+
Sbjct: 248 LMLVDERQMHIEQLGLQ------------SQKVQDLTQKLREEEEKLKAITSKSKEDRQK 295
Query: 201 CEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEE 260
+L++ + + + E+E MN KL + + N + K ++E+L+E
Sbjct: 296 LLKLEVD---FEHKASRFSQEHEEMNAKL----ANQESHNRQLRLKLVGLTQRIEELEET 348
Query: 261 NFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLE 320
N L+ A+++ +EL ++ + + N +SL E L+ + + ++ K E
Sbjct: 349 NKNLQKAEEEL----QELRDKIAKGECGN---SSLMAEVENLRKRVLEMEGKDEEITKTE 401
Query: 321 STVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQ----LETYKR 376
S R+KLQ+ K+++ E M LEE K+ + TQ LE K
Sbjct: 402 SQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKN 461
Query: 377 QVQDLHVKLSSESKRADTLAFEMKRLEEKH----EALLKEKERLIEQRDTLKETNEELRC 432
+DL +L R L RLE+ + L K K + D K E+++
Sbjct: 462 LTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQ 521
Query: 433 SQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSE-----NE 487
+ + D LN K+++ ++M V + ++ K+L+L+ E E
Sbjct: 522 EERKVDGLN-------KNFKVEQGKVMDVTEK----LIEESKKLLKLKSEMEEKVYNLTR 570
Query: 488 RIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLK 547
+EL +L+ + K +EL L K+R+ +++ ++ + +GS+ +K+K
Sbjct: 571 ERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIK 630
Query: 548 ------QKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDM-- 599
++L+ +++L V +L K ++ + L+ K N L L++ +
Sbjct: 631 ELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAK 690
Query: 600 -KAMEERYKMYLE-KARNVIKTLDPKLNPASAEIMLLRKQLAE---KERRIEILESECKV 654
KA+E+ + E + R+ + + K AE+ L++++ E KE ++ L+ + V
Sbjct: 691 NKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSV 750
Query: 655 AKFRDYEE----------------KLIVSAWYNKSL------------AFQKLGMESRLV 686
+ R EE +L +S Y+++L G+++ V
Sbjct: 751 LQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAV 810
Query: 687 SGGGACSDTGACTPARSFLAQQRHITNTRRNLSVKVPATTS 727
SG A +T A +SF ++ HI + R + +K P S
Sbjct: 811 SGEAAEEETPAVFIRKSF-QEENHIMSNLRQVGLKKPVERS 850
Score = 79.7 bits (195), Expect = 9e-15
Identities = 123/540 (22%), Positives = 224/540 (41%), Gaps = 120/540 (22%)
Query: 157 QELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCE-ELDMQVTTLQDEK 215
QE E + P + LE++ K + E L E+ +R EL+ + D
Sbjct: 135 QEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYM 194
Query: 216 NSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEA----AKDDY 271
N ++ ++ ++L + A+K +L +L++E +L++ D+
Sbjct: 195 NKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDER 254
Query: 272 RVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQ 331
++H E+L Q + Q + T+ L++E + L+A + K+ + RQKL
Sbjct: 255 QMHIEQLGLQSQKVQ----------DLTQKLREEEEKLKAITSKSKE-------DRQKLL 297
Query: 332 DLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKR 391
L + + H +E ++ NA E++ RQ L +KL ++R
Sbjct: 298 KL-------------EVDFEHKASRFSQEHEEMNAKLANQESHNRQ---LRLKLVGLTQR 341
Query: 392 ADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSY 451
++ LEE ++ L K +E L E RD + A
Sbjct: 342 -------IEELEETNKNLQKAEEELQELRDKI---------------------AKGECGN 373
Query: 452 ENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQR 511
+L AE+ EN R+ + ++E I + + Q + +K+ E E +
Sbjct: 374 SSLMAEV--------------ENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSK 419
Query: 512 LSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELI 571
+ + +LQ+++ +L+K L+E SKS+ E T++H L+K++ L
Sbjct: 420 ELRLEVEKLQKRMSELEK-LEEAFSKSKSE---------------CTQLHLNLEKEKNLT 463
Query: 572 EDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEI 631
+DL +NELE ++ + ++++ E R LEKA +K KL + +
Sbjct: 464 KDL----------LNELE-VVKSRVKELECSESR----LEKAELSLKDDLTKLKSFTVML 508
Query: 632 MLLRKQLAEK----ERRIEILESECKV--AKFRDYEEKLIVSAWYNKSLAFQKLGMESRL 685
+ RK + EK ER+++ L KV K D EKLI +K L K ME ++
Sbjct: 509 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEE---SKKLLKLKSEMEEKV 565
Score = 31.6 bits (70), Expect = 2.7
Identities = 38/162 (23%), Positives = 72/162 (44%), Gaps = 12/162 (7%)
Query: 513 SKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTE----VHEELQKKQ 568
+K++ + +++ + + ++ K+ GE K K+ LE E L + + ELQ ++
Sbjct: 36 AKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQARE 95
Query: 569 ELI-----EDLQPDINQNVQKINELEAALQKKDEDMKAMEERY--KMYLEKARNVIKTLD 621
++I E +P++ + E E L+ D +E+ + EK + + L+
Sbjct: 96 DVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLE 155
Query: 622 PKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEK 663
K + ML + LAEK R + E E + K DY K
Sbjct: 156 EK-QKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNK 196
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 104 bits (260), Expect = 3e-22
Identities = 98/440 (22%), Positives = 212/440 (48%), Gaps = 35/440 (7%)
Query: 178 QQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFD 237
++LKR LE + L +++L+ + L ++ ++ + + V ENE+ N Q +
Sbjct: 245 KELKRKLERAK-LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMW 303
Query: 238 DPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAE 297
+ + Q Q E+++E+ ++ ++ R EE+ + E R +E+ E
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ-EEMMWEKEEKMRRQEEMMWEKE 362
Query: 298 ETRALKDEI-----DVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMH 352
E +E+ + +R +K ++ E E +K Q+ +R+Q K ++ M+
Sbjct: 363 EKMRRLEEMMWEKEEKIRELEEKMHEQEKIRE-QEEKRQEEEKIREQEKRQEQEAKMWRQ 421
Query: 353 NTVSLEEELKKANAARTQLETYKRQVQDLHV--KLSSESKRADTLAFEMKRLEEK---HE 407
E+E K R Q + RQ + +H K+ E KR + EM R EEK E
Sbjct: 422 EEKIREQEEK----IREQEKKMWRQEEKIHEQEKIREEEKRQEQE--EMWRQEEKIREQE 475
Query: 408 ALLKEKERLIEQRDTLKETNEELRCSQV---QQDHLNQTDASATKSYENLAAEIMPVEYR 464
+ ++KE++ EQ K+ + R + Q++ + + + + E + + + +
Sbjct: 476 EIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQ 535
Query: 465 EVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQI 524
E IR Q E + ++ G + E+++E QE++ ++ K+ E E + R KE+IRE +++I
Sbjct: 536 EEKIREQEEMMQEQEEKMGEQEEKMQE-QEKMRRQEEKIREQEEKIREQKEKIREQEEKI 594
Query: 525 EDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQK 584
+ ++ ++EQ ++ ++ EK+ E E++ +++E +++ + + + +K
Sbjct: 595 WEQEEKIREQ------------EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 642
Query: 585 INELEAALQKKDEDMKAMEE 604
+ E E L++++E M+ +E
Sbjct: 643 MWEQEVRLRQQEEKMQEHQE 662
Score = 100 bits (250), Expect = 4e-21
Identities = 108/539 (20%), Positives = 253/539 (46%), Gaps = 53/539 (9%)
Query: 135 QEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEK 194
Q H I+T +++ + + Q + + L D + L K A EL++AL+
Sbjct: 128 QVHTIRILTCQKTELQMALYYSQHAVKQ--LEGEARDLISRLHDSWKFA-GELEQALSAV 184
Query: 195 EELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQL 254
+++ + ++T +D + + N + +E+L + + + +V + QL +
Sbjct: 185 ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV 244
Query: 255 EQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATS- 313
++L+ +LE AK + ++L+ E H EL S++ + +A +E ++ +
Sbjct: 245 KELKR---KLERAK--LLLPQQQLQA---EADHLGKELQSVSAKLQAQVEENELWNRLNQ 296
Query: 314 ---DKANKLESTVEIYRQKLQDLND-LRKQVKTLQETNMMYMHNTVSLEEELKKANAART 369
+K + E ++ + +K+Q+ + +R+Q + ++E EE++++
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ-----------EEKMRRQEEMMW 345
Query: 370 QLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEE 429
+ E R+ +++ + + +R + + +E + + E + E+E++ EQ + +E E+
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE-EEK 404
Query: 430 LRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERI 489
+R +Q+ + +A + E + + E IR Q E KM R +++ E E+I
Sbjct: 405 IR----EQEKRQEQEAKMWRQEEKIREQ-------EEKIREQ-EKKMWRQEEKIHEQEKI 452
Query: 490 EELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQK 549
E +++ EQ+ E +E+IRE ++ +K +++ + + E + ++K
Sbjct: 453 REEEKRQEQE---------EMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEK 503
Query: 550 LEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMY 609
+ EK+ E E++ +++E I + + I + +KI E E +Q+++E M EE+ +
Sbjct: 504 MHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQ 563
Query: 610 --LEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILES--ECKVAKFRDYEEKL 664
+ + I+ + K+ +I +++ E+E +I E + + K + EEK+
Sbjct: 564 EKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKM 622
Score = 99.0 bits (245), Expect = 1e-20
Identities = 115/513 (22%), Positives = 242/513 (47%), Gaps = 57/513 (11%)
Query: 174 GELEQQLKRALEELQEALAEKEELRQRCEELDMQV--TTLQDEKNSLVSENEMMNEKLDQ 231
GELEQ L + ++A EEL + + L +++ T+ DE+ L +N + EKL
Sbjct: 175 GELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE--LKEKNAKLQEKLQL 232
Query: 232 LDGSFDDPNTVVA---KKYFHAQLQLEQ-------------LQEENFRLEAAKDDY---- 271
++ + V +K A+L L Q LQ + +L+A ++
Sbjct: 233 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 292
Query: 272 RVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQ 331
R++ ++ EK + + + + E+ ++++ + +R +K + E + +K++
Sbjct: 293 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352
Query: 332 DLNDL----RKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSS 387
++ ++++ L+E LEE++ + R Q E KRQ ++ K+
Sbjct: 353 RQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEE--KRQEEE---KIRE 407
Query: 388 ESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQ-VQQDHLNQTDAS 446
+ KR + A +M R EEK + +++E++ EQ + E++ + ++++ Q
Sbjct: 408 QEKRQEQEA-KMWRQEEK---IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEE 463
Query: 447 ATKSYENLAAEIMPVEYREVFIRLQ--HENKMLRLQ------QEGSENERIEELQEQLEQ 498
+ E + E E++ + + HE + +R Q QE +++ E+++EQ E
Sbjct: 464 MWRQEEKIR------EQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEE- 516
Query: 499 KHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSK-SEGESSSKLKQKLEAHMEKL 557
KM E + R +E+IRE +++I + ++ +QEQ K E E + ++K+ EK+
Sbjct: 517 ---KMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKI 573
Query: 558 TEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVI 617
E E++++++E I + + I + +KI E E +Q+++E M EE+ EK +
Sbjct: 574 REQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 633
Query: 618 KTLDPKLNPASAEIMLLRKQLAEKERRIEILES 650
+ + + + + LR+Q + + E LE+
Sbjct: 634 EKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 102 bits (255), Expect = 1e-21
Identities = 130/517 (25%), Positives = 242/517 (46%), Gaps = 64/517 (12%)
Query: 158 ELMSKEILSSPPNDAVGELEQQLK-RALEELQEALAEKEELRQRCEELDM----QVTTLQ 212
E+ +KE +P +D +E + LE LQ+ + +E L +RC+E Q T L
Sbjct: 256 EVFTKE--ENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLT 313
Query: 213 DEKNSLVSENEMMNEKLDQLDGSFD---DPNTVVAKKYFHAQLQLEQL-QEENFRLEAAK 268
EK +L E ++E+L +L+ D T + + A+ +EQL Q++ + K
Sbjct: 314 SEKEAL---QEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETK 370
Query: 269 DDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQ 328
E E+++ + + R ++T+ EE R K++ + RA ++ K ST + +
Sbjct: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSE--RAAFEELEKALSTAQKTEE 428
Query: 329 KLQDLN-DLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSS 387
+ L ++ +Q+KT+++T+ +SL++EL + K++V D+ +K SS
Sbjct: 429 ARRKLKAEMDEQIKTIEKTSE---EERISLQQELSRV----------KQEVVDV-MKKSS 474
Query: 388 ESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASA 447
E + A K L K + L K+ + +R+ ++ L SQ + ++Q
Sbjct: 475 EEQIAKLQKLHEKELARKEQELTKKLQT--REREFQEQMKVALEKSQSEYLKISQEK--- 529
Query: 448 TKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSE-NERIEELQEQLE---QKHRKM 503
+ E+LA E +E ++ I + ENK+ LQQE RI EL+ LE Q+++
Sbjct: 530 -EQQESLALE--ELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586
Query: 504 NE-----LETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLT 558
++ LE E+ + I + ++ + +SL+ Q E LKQ+ + MEKL
Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646
Query: 559 EVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLE--KARNV 616
E E Q+K+ L++D + +++++N E L+K D +E E KAR+
Sbjct: 647 EKCE--QEKETLLKDKEIIFQAHIEEMN--EKTLEKLDVKQTELESLSSELSEVLKARHK 702
Query: 617 IKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECK 653
++ E+ +L+ Q + ++ +E E K
Sbjct: 703 LE----------EELSVLKDQTDKMKQELEAKMDEQK 729
Score = 98.6 bits (244), Expect = 2e-20
Identities = 133/621 (21%), Positives = 274/621 (44%), Gaps = 70/621 (11%)
Query: 79 KKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAINCEKKQEHI 138
++ L ++S + + L QQ E + ++++I E+ L Q IL CEK++ +
Sbjct: 1037 RRELNDVISIWEKKLNQQAEE--LQEIHEIQLQEKEQEVAELKQKIL--LFGCEKEEMNK 1092
Query: 139 QNIMTLEESV-QHVVMTAIQELMSKEI--LSSPPNDA------VGELEQQLKRALEE--- 186
+ EE V Q + +QE + ++ ++S D + +LE L ++L+E
Sbjct: 1093 EITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF 1152
Query: 187 LQEALAE----KEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTV 242
LQE L E EE +++ EL ++ T +E SL S +E N+ L+ F +
Sbjct: 1153 LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1212
Query: 243 VAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLI--EFQHRNDELTSLAEETR 300
+A +QL+ ++ L AK + ++ + I H T + E
Sbjct: 1213 LA-------IQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALL 1265
Query: 301 ALKDEIDVLRATSDKANKLESTVEI-YRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEE 359
+ L A + + ++T+ I ++Q L + Q+K+++ + +L++
Sbjct: 1266 IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQK 1325
Query: 360 ELKKANAARTQLET------------------YKRQVQDLHVKLSSESKRADTLAFEMKR 401
E A ++ E+ K ++++ V++SS SK+ L +++
Sbjct: 1326 EGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN 1385
Query: 402 ---LEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEI 458
L EK A+ +++ E++ L + ++L + D L++ SA + ++ + +
Sbjct: 1386 SISLSEKEAAISSLRKQYDEEKCELLDQVQDL---SFKVDTLSKEKISALEQVDDWSNKF 1442
Query: 459 MPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIR 518
+ + QH+N ++ELQ QLE K ++ E + + L KE +
Sbjct: 1443 SEWKKKAQSRFTQHQNT-------------VKELQIQLELKSKEAYEKDEQINLLKEELD 1489
Query: 519 ELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDI 578
+ ++ + L+ +++ SK E + S L+ +L++ ++ E+ + + +K IE L +
Sbjct: 1490 QQNKRFDCLKGEMEDDKSKME-KKESNLETELKSQTARIMELEDHITQKTIEIESLNEVL 1548
Query: 579 -NQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQ 637
N N QK E + +QK + EE+ +++A I TL+ ++ AE+ +K+
Sbjct: 1549 KNYNQQKDIEHKELVQKLQHFQELGEEKDNR-VKEAEEKILTLENQVYSMKAELETKKKE 1607
Query: 638 LAEKERRIEILESECKVAKFR 658
L ++ E E K + R
Sbjct: 1608 LEHVNLSVKSKEEELKALEDR 1628
Score = 87.0 bits (214), Expect = 5e-17
Identities = 139/614 (22%), Positives = 269/614 (43%), Gaps = 97/614 (15%)
Query: 133 KKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPND-----AVGELEQQLKRALEE- 186
K+QE + + T E Q + A+++ S+ + S + A+ ELE Q K L E
Sbjct: 492 KEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTES 551
Query: 187 ---LQEALAEKEELRQRCEELDMQVT-TLQDEKNS-------LVSENEMMNEKLD----- 230
L++ E E R R EL+ + +LQ+ KN L +E N+++
Sbjct: 552 ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK 611
Query: 231 ----------QLDGSFDDPNTVVAKKYFHAQLQLEQL-----QEENFRLEAAKDDYRVHC 275
Q D + + V+ ++Y Q ++E+L QE+ L+ + ++ H
Sbjct: 612 HKTELESLKHQQDALWTEKLQVLKQQY---QTEMEKLREKCEQEKETLLKDKEIIFQAHI 668
Query: 276 EEL-EKQLIEFQHRNDELTSLAEET-------RALKDEIDVLRATSDKANK-LESTVEIY 326
EE+ EK L + + EL SL+ E L++E+ VL+ +DK + LE+ ++
Sbjct: 669 EEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ 728
Query: 327 RQKLQDLND--LRKQVKTLQETNMMYMHNTVSLEEELKKANAA----RTQLETYKRQVQD 380
+ Q D +++ ++Q T LE LK+ + + +E + ++
Sbjct: 729 KNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788
Query: 381 LHVKLSSESKRAD------------TLAFEMKRLEEKHEALLKEKERLI------EQRDT 422
+L S + D T A+E + + + + L E ER++ E
Sbjct: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 848
Query: 423 LKETNEELRCSQVQ-QDHLNQTDA----------SATKSYENLAAEIMPVEYREVFIRLQ 471
K+ EL ++Q QD + Q + S T+ YE+ + + + I ++
Sbjct: 849 KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVE 908
Query: 472 HENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSL 531
EN +L+++ EG + E IE L ++L K ++ L E + + ++++ K +
Sbjct: 909 KENMILQMR-EGQKKE-IEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEM 966
Query: 532 QEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAA 591
QE K + +KLK++LE +L++ +E Q +++E Q + ++ LE
Sbjct: 967 QETLKKKLLDQEAKLKKELENTALELSQ--KEKQFNAKMLEMAQANSAGISDAVSRLETN 1024
Query: 592 LQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRK-QLAEKERRIEILES 650
+++ E + + R + +VI + KLN + E+ + + QL EKE+ E+ E
Sbjct: 1025 QKEQIESLTEVHRR------ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ--EVAEL 1076
Query: 651 ECKVAKFRDYEEKL 664
+ K+ F +E++
Sbjct: 1077 KQKILLFGCEKEEM 1090
Score = 83.2 bits (204), Expect = 8e-16
Identities = 125/553 (22%), Positives = 244/553 (44%), Gaps = 64/553 (11%)
Query: 138 IQNIMTLEESVQHVVMTAIQELMSKEILSS------PPNDAVGELEQQLKRALEELQEAL 191
I+ + S + +V T+ +E +++ L S PP+D E E + + ++L
Sbjct: 80 IKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNS-----DSL 134
Query: 192 AEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQ 251
KE+L QR ++ +++ + + + LV+ +M+ + +L G ++ A+
Sbjct: 135 -NKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRI--AE 191
Query: 252 LQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRA 311
L+ E+LQ + + ++++ EE ++ + Q +++ L + R +DVL+
Sbjct: 192 LR-EELQMDQQAKKHLQEEFDASLEEKDQYISVLQ---TQVSLLKQRLRNGPMNVDVLKP 247
Query: 312 TSDKANKLESTVEIYRQKLQDLNDLRK------QVKTLQETNMMYMHNTVSLEEELKKAN 365
+LE E++ ++ +D VKTL+ + V +E L K
Sbjct: 248 LP----QLEPQAEVFTKEENPESDGEPVVEDGTSVKTLET-----LQQRVKRQENLLKR- 297
Query: 366 AARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKE 425
+ ++++K Q L + + ++ D E++++++ H A EK +LI Q K
Sbjct: 298 -CKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA---EKTKLITQLRDAKN 353
Query: 426 TNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSE 485
E+L Q + + +T ++ E EI + R + Q E LR Q+E SE
Sbjct: 354 LIEQLE--QDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE--LREQKEKSE 409
Query: 486 NERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSK 545
EEL++ L + + E+I+ +++ E+ + SLQ++ S+ + E
Sbjct: 410 RAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDV 469
Query: 546 LKQKLEAHMEKLTEVHEE--LQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAME 603
+K+ E + KL ++HE+ +K+QEL + LQ E E Q K K+
Sbjct: 470 MKKSSEEQIAKLQKLHEKELARKEQELTKKLQ---------TREREFQEQMKVALEKSQS 520
Query: 604 ERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQ-LAEKERRIEILESECKVAKFR--DY 660
E K+ EK + L+ E+ L +K L E E ++ L+ E + + R +
Sbjct: 521 EYLKISQEKEQQESLALE--------ELELQKKAILTESENKLRDLQQEAETYRTRILEL 572
Query: 661 EEKLIVSAWYNKS 673
E L S NK+
Sbjct: 573 ESSLEKSLQENKN 585
Score = 72.8 bits (177), Expect = 1e-12
Identities = 128/585 (21%), Positives = 248/585 (42%), Gaps = 94/585 (16%)
Query: 135 QEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQ-EALAE 193
+E + I+TLE V M A E KE+ N +V E++LK + L+ E+ A+
Sbjct: 1581 KEAEEKILTLENQVYS--MKAELETKKKEL--EHVNLSVKSKEEELKALEDRLESESAAK 1636
Query: 194 KEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQ 253
EL+++ E+ ++ ++ + S + E E +K + + NT + ++ +
Sbjct: 1637 LAELKRKAEQ---KIAAIKKQLLSQMEEKEEQYKK--GTESHLSELNTKLQEREREVHIL 1691
Query: 254 LEQL------QEENFRLEAAKDDYRVHCEELEKQLIE-FQHRNDELTSLAEETRALKDEI 306
E+L Q E + + + + E+ E Q +E S+ + K+++
Sbjct: 1692 EEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL 1751
Query: 307 DVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKAN- 365
+ R +K + S E+ Q + L L E M H LEE+ KK +
Sbjct: 1752 -LQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810
Query: 366 --AARTQLETYKRQVQ----------DLHVKLSSESKRADTLAFEMKRLE-------EKH 406
A + E K +Q D+ L + L ++K L+ E H
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870
Query: 407 EALLKE------KERLIEQRD-------TLKETNEE-----------LRCSQVQQDHLNQ 442
++E K + ++Q D L+E EE L + Q + L
Sbjct: 1871 RVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEF 1930
Query: 443 TDASATKSYENLAAEIMPVEYREVFIRLQHENKM--LRLQQEGSENERIEELQEQLEQKH 500
A A + + L EI+ ++ +R +H+ ++ L+ + + E+I++ QE LE KH
Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKH 1990
Query: 501 RKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKS---EGESSSKLKQKLEAHMEKL 557
T ++L +E +L Q+ ++L+ +++E +K+ E E +++ ++K+
Sbjct: 1991 NS-----TLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKI 2045
Query: 558 TEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKA-MEERYKMYLEKARNV 616
E ++L++ + E++ ++ E + K D++ +EE K Y +K
Sbjct: 2046 AEKDDDLKRTAKRYEEI----------LDAREEEMTAKVRDLQTQLEELQKKYQQK---- 2091
Query: 617 IKTLDPKLNPA--SAEIMLLRKQLAEKERRIEILESECKVAKFRD 659
L+ + NP + IM L+ QLA+K I +S+ K +FR+
Sbjct: 2092 ---LEQEENPGNDNVTIMELQTQLAQKTTLIS--DSKLKEQEFRE 2131
Score = 32.7 bits (73), Expect = 1.2
Identities = 33/158 (20%), Positives = 68/158 (43%), Gaps = 16/158 (10%)
Query: 130 NCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQE 189
N + Q+ + MT++E++ + L S + ++ + E + LKR + +E
Sbjct: 2002 NTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE 2061
Query: 190 AL-AEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYF 248
L A +EE+ + +L Q+ LQ + +KL+Q + +D T++
Sbjct: 2062 ILDAREEEMTAKVRDLQTQLEELQ----------KKYQQKLEQEENPGNDNVTIM----- 2106
Query: 249 HAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQ 286
Q QL Q + + ++R LE +L +++
Sbjct: 2107 ELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 102 bits (253), Expect = 2e-21
Identities = 143/642 (22%), Positives = 285/642 (44%), Gaps = 95/642 (14%)
Query: 134 KQEHIQNIMTLEESVQHVVMTAIQE---LMSKEILSSPPNDAVGELEQQLKRALEELQEA 190
+QE+ + I E+ V +++ ++ + L D V +LE++ K E L+++
Sbjct: 254 EQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQS 313
Query: 191 LAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQL----DGSFDDPN------ 240
+ ++ L + E++ + + + +L + ++ + + QL + ++ N
Sbjct: 314 IEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAH 373
Query: 241 TVVAKKYFHAQLQLEQL-QEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLA--- 296
+ V ++ LE+L + E RLE +D ++ EL+K+ E + E+T L
Sbjct: 374 SFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELE----EMTKLTNNK 429
Query: 297 ----EETRALKDEIDVLRATSDKANKLESTVEIYRQKL--------QDLNDLRKQVKTLQ 344
EE + + E + L + + K+ ++ Q+L ++++DL Q+ +
Sbjct: 430 EVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAIT 489
Query: 345 ETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEE 404
+ Y L+ EL+ T+L ++ ++ + +L+ E+ + E+K +E
Sbjct: 490 TSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETS---DMTLELKNQQE 546
Query: 405 KHEALLKEKERLIEQRDTLKETNEELR--CSQVQQDHLNQTD---ASATKSYENLAAEIM 459
K++ER+++Q + L+ET +LR V+++ + D KS EN
Sbjct: 547 DINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRK 606
Query: 460 PVEYREVFIR-LQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIR 518
VE + +I LQ ENK L+ ++G+ + QL K+N+LE E +K++
Sbjct: 607 QVENKNKYIEELQQENKALK--KKGTAESK------QLNVYEIKVNKLELELESAKQKFG 658
Query: 519 EL----QQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDL 574
E+ Q++IED K + E+ E +EK + +E K L
Sbjct: 659 EITDTYQKEIED--KKISEENLLEE--------------VEKAKVIADEAVK-------L 695
Query: 575 QPDINQNVQ-KINELEAALQK-KDEDMKAMEER------YKMYLEKARNVIKTLDPKLNP 626
Q +I++ Q KI E+ A ++K K + K +EER YK ++ ++ +L+ +L+
Sbjct: 696 QKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSN 755
Query: 627 ASAEIMLLRKQLAEKERRIEILESECK--VAKFRDYEEKLIVSAWYNKSLAFQKL---GM 681
AE++ ++KQL + E L+ E K A ++ ++K + + KL +
Sbjct: 756 LKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAV 815
Query: 682 ESRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSVKVP 723
S+ VS D G R +L T+ + LS +P
Sbjct: 816 PSQTVSRNFTSVDHGISKDKRDYL-----WTSAKNTLSTPLP 852
Score = 94.0 bits (232), Expect = 4e-19
Identities = 143/679 (21%), Positives = 302/679 (44%), Gaps = 88/679 (12%)
Query: 57 ESWLSRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVE 116
E+ L + + + +N +I + K + + + + +E + ++ E + + + I E +
Sbjct: 124 EAELRQKESKLQENRKIIEAQRKAIQE--LQFGNEKVSLKLEEGIQENKDLIKENNATRH 181
Query: 117 LGRLLQLILGCAINCEK-------KQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPP 169
L LL+ CA + EK ++E Q M L +++ ++ TA +EL +
Sbjct: 182 LCNLLKET--CARSAEKTKKYEYEREETRQVYMDLNNNIEKMI-TAFEELRVQA------ 232
Query: 170 NDAVGELEQQLKRALEELQEALAE-KEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEK 228
++ E+ +LK E++Q E K+E+ + +++ + + + +++N + ++ E
Sbjct: 233 ENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEES 292
Query: 229 LDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEE---LEKQLIE- 284
D++ N + K ++ L+Q E+ L +D +V + +K L E
Sbjct: 293 RDKV-------NQLEEKTKLQSE-NLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEED 344
Query: 285 FQHRNDELTSLAEETRALKDEIDVLRAT-SDKANKLESTV----EIYRQKLQDLNDLRKQ 339
Q + L EE +E + RA S + E+TV E+ R + Q L Q
Sbjct: 345 LQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQ 404
Query: 340 VKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEM 399
+K L M + LEE K N +LE K+ + + L E+K+ + +A E+
Sbjct: 405 LKIL---TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLY-ENKQFEKIAEEL 460
Query: 400 KRLEEKHEALLKEKERLIEQRD---TLKETNEELRCSQV-------QQDHLNQTDASATK 449
K E++ LL+ +E+ + + T T+E+ +V + + L T+ ++
Sbjct: 461 KGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHC 520
Query: 450 SYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSEN-----ERIEELQEQL-------- 496
+ +L + + E ++ + L+++ + + ++ E E ++E + QL
Sbjct: 521 NKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVR 580
Query: 497 EQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEK 556
E+ +K +E++ + S+E L++Q+E+ K ++E L+Q+ +A +K
Sbjct: 581 EELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEE------------LQQENKALKKK 628
Query: 557 LTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNV 616
T ++L + + L+ ++ QK E+ QK+ ED K EE +EKA+ +
Sbjct: 629 GTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVI 688
Query: 617 I-------KTLDPKLNPASAE-IMLLRKQLAEKERRIEILESECKVAKFRDYEEKLIVSA 668
K +D + AE + L+ K + ++ IE +SE + K ++ E+ +
Sbjct: 689 ADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSL--- 745
Query: 669 WYNKSLAFQKLGMESRLVS 687
SL + +++ L+S
Sbjct: 746 --RASLEIELSNLKAELLS 762
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 101 bits (251), Expect = 3e-21
Identities = 105/505 (20%), Positives = 232/505 (45%), Gaps = 41/505 (8%)
Query: 178 QQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFD 237
++LKR LE + L +++L+ + L ++ ++ + + V ENE+ N Q +
Sbjct: 245 KELKRKLERAK-LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMW 303
Query: 238 DPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAE 297
+ + Q Q E+++E+ ++ ++ R EE+ + E R +E+ E
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ-EEMMWEKEEKMRRQEEMMWEKE 362
Query: 298 ETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSL 357
E ++E+ +K K+ E+ +K + + +L ++ MH +
Sbjct: 363 EKMRRQEEM-----MWEKEEKMRRQEEMMWEKEEKIRELEEK-----------MHEQEKI 406
Query: 358 EEELKKANAARTQLETYKRQVQDLHV-----KLSSESKRADTLAFEMKRLEEK--HEALL 410
E+ +K E KRQ Q+ + K+ + ++ +M R EEK + +
Sbjct: 407 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKI 466
Query: 411 KEKERLIEQRDTLKETNEELRCSQV--QQDHLNQTDASATKSYENLAAEIMPVEYREVFI 468
+E+E+ EQ + ++ + ++ Q++ +++ + K E + + + +E I
Sbjct: 467 REEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKI 526
Query: 469 RLQHENKMLRLQQEGSENERIEELQEQLEQKHR-----KMNELETEQRLSKERIRELQQQ 523
R Q E KM R +++ E E + +E++ ++ + K E E + +E+IRE +++
Sbjct: 527 REQEE-KMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEK 585
Query: 524 IEDLQKSLQEQGSKSEGESSSKLKQ--KLEAHMEKLTEVHEELQKKQELIEDLQPDINQN 581
+ ++ ++EQ K + + KQ K+ EK+ E E++++++E I + + +
Sbjct: 586 VWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQ 645
Query: 582 VQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEK 641
+K+ E E + +++E M+ EE EK I+ + K+ +I + + E+
Sbjct: 646 EEKMGEQEEKMCEQEEKMQEQEETMWRQEEK----IREQEKKIREQEEKIREQEEMMQEQ 701
Query: 642 ERRI-EILESEC-KVAKFRDYEEKL 664
E ++ E E C + K ++ EEK+
Sbjct: 702 EEKMWEQEEKMCEQEEKMQEQEEKM 726
Score = 97.8 bits (242), Expect = 3e-20
Identities = 80/437 (18%), Positives = 212/437 (48%), Gaps = 16/437 (3%)
Query: 178 QQLKRALEELQEALAEKEE-LRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSF 236
Q+ + ++E +E + E+EE +R++ E++ Q + +++ + + EMM EK +++
Sbjct: 310 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ- 368
Query: 237 DDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLA 296
++ +K + + + +E+ LE + E+ EK+ E + R E
Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ-E 427
Query: 297 EETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVS 356
+E + + E + +R +K + E + +K+ + +R++ K ++ M +
Sbjct: 428 QEAKMWRQE-EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIH 486
Query: 357 LEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERL 416
+EE+ + Q E Q + + + ++ + + + +++ E+ E + +++E++
Sbjct: 487 EQEEIWR------QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKI 540
Query: 417 IEQRDTLKETNEELRCSQVQQDHLNQTDASAT-KSYENLAAEIMPVEYREVFIRLQHENK 475
EQ + +E + ++ ++ Q + E + + V +E IR Q E +
Sbjct: 541 REQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKR 600
Query: 476 MLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQG 535
+ ++ + E+I E +E+++++ K+ E E + R +E +E ++++ + ++ + EQ
Sbjct: 601 QEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQE 660
Query: 536 SKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKK 595
K + + + +Q+ EK+ E +++++++E I + + + + +K+ E E + ++
Sbjct: 661 EKMQEQEETMWRQE-----EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 715
Query: 596 DEDMKAMEERYKMYLEK 612
+E M+ EE+ + EK
Sbjct: 716 EEKMQEQEEKMRRQEEK 732
Score = 95.1 bits (235), Expect = 2e-19
Identities = 95/472 (20%), Positives = 220/472 (46%), Gaps = 40/472 (8%)
Query: 132 EKKQEHIQNIMTLEESV--QHVVMTAIQELM-SKEILSSPPNDAVGELEQQLKRALEELQ 188
EK QE + I EE + Q M +E+M KE + + E E++++R +
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ----E 369
Query: 189 EALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYF 248
E + EKEE +R EE+ + ++EK + E EK+ + + + + ++
Sbjct: 370 EMMWEKEEKMRRQEEMMWE----KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR 425
Query: 249 HAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDV 308
Q QEE R + K E EK++ + + E + EE + + E ++
Sbjct: 426 QEQEAKMWRQEEKIREQEEK------IREQEKKMWRQEEKIHEQEKIREEEKRQEQE-EM 478
Query: 309 LRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAAR 368
R + K+ EI+RQK + +++ ++++ +E EE++++
Sbjct: 479 WR----QEEKIHEQEEIWRQK-EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKM 533
Query: 369 TQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNE 428
+ E R+ +++ + E +E ++ +E+ + + +++E++ EQ + + E
Sbjct: 534 WRQEEKIREQEEMWRE--EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEE 591
Query: 429 ELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENER 488
++R Q++ + + K E + + ++ +E IR Q E + + + E+
Sbjct: 592 KIR---EQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEK 648
Query: 489 IEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQ 548
+ E +E++ ++ KM E E +E+IRE +++I + ++ ++EQ ++
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQ------------EE 696
Query: 549 KLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMK 600
++ EK+ E E++ +++E +++ + + + +K+ E E L++++E M+
Sbjct: 697 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 94.7 bits (234), Expect = 3e-19
Identities = 110/567 (19%), Positives = 251/567 (44%), Gaps = 84/567 (14%)
Query: 174 GELEQQLKRALEELQEALAEKEELRQRCEELDMQV--TTLQDEKNSLVSENEMMNEKLDQ 231
GELEQ L + ++A EEL + + L +++ T+ DE+ L +N + EKL
Sbjct: 175 GELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE--LKEKNAKLQEKLQL 232
Query: 232 LDGSFDDPNTVV---AKKYFHAQLQLEQ-------------LQEENFRLEAAKDD----Y 271
++ + V +K A+L L Q LQ + +L+A ++
Sbjct: 233 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 292
Query: 272 RVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQ 331
R++ ++ EK + + + + E+ ++++ + +R +K + E + +K++
Sbjct: 293 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352
Query: 332 DLNDL--RKQVKTLQETNMMY--------------------------MHNTVSLEEELKK 363
++ K+ K ++ MM+ MH + E+ +K
Sbjct: 353 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 412
Query: 364 ANAARTQLETYKRQVQDLHV-----KLSSESKRADTLAFEMKRLEEK--HEALLKEKERL 416
E KRQ Q+ + K+ + ++ +M R EEK + ++E+E+
Sbjct: 413 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 472
Query: 417 IEQRDTLKETNEELRCSQV--QQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHEN 474
EQ + ++ + ++ Q++ +++ + K E + + + +E IR + E
Sbjct: 473 QEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIR-EQEE 531
Query: 475 KMLRLQQEGSENERIEELQEQLEQKHR-----KMNELETEQRLSKERIRELQQQIEDLQK 529
KM R +++ E E + +E++ ++ + K E E + +E+IRE ++++ ++
Sbjct: 532 KMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEE 591
Query: 530 SLQEQGSKSEGESSSKLKQ---------KLEAHMEKLTEVHEELQKKQELIEDLQPDINQ 580
++EQ K + + KQ K++ EK+ E E++++++E+ ++ + + +
Sbjct: 592 KIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGE 651
Query: 581 NVQKINELEAALQKKDEDMKAMEERYKMYLEKAR---NVIKTLDPKLNPASAEIMLLRKQ 637
+K+ E E +Q+++E M EE+ + +K R I+ + + ++ ++
Sbjct: 652 QEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK 711
Query: 638 LAEKERRIEILESECKVAKFRDYEEKL 664
+ E+E +++ E K R EEK+
Sbjct: 712 MCEQEEKMQEQEE-----KMRRQEEKM 733
Score = 35.0 bits (79), Expect = 0.25
Identities = 27/146 (18%), Positives = 72/146 (49%), Gaps = 10/146 (6%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEAL 191
EK +E + I EE ++ +++ +E ++ + +GE E+++ E++QE
Sbjct: 612 EKIREQEEKIQEQEEKIREQE----EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE-- 665
Query: 192 AEKEELRQRCEELDMQVTTLQDEKNSLVSENEMM---NEKLDQLDGSFDDPNTVVAKKYF 248
++E + ++ E++ Q +++++ + + EMM EK+ + + + + ++
Sbjct: 666 -QEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 724
Query: 249 HAQLQLEQLQEENFRLEAAKDDYRVH 274
+ Q E++ E+ RL ++ + H
Sbjct: 725 KMRRQEEKMWEQEVRLRQQEEKMQEH 750
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 101 bits (251), Expect = 3e-21
Identities = 131/545 (24%), Positives = 236/545 (43%), Gaps = 69/545 (12%)
Query: 133 KKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALA 192
+K ++ I LE + + E S+ D +GE + LK LE+ ++ A
Sbjct: 1098 QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRD-LGEELEALKTELEDTLDSTA 1156
Query: 193 EKEELR-QRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQ 251
++ELR +R +E+++ TL++E + ++ + M +K Q + + K A
Sbjct: 1157 AQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAE--QLEQTKRVKAN 1214
Query: 252 LQLEQLQEENFRLEAA---------KDDYRVHCEELEKQLIEFQHRNDE----LTSLAEE 298
L+ + EN R E A K D +++E QL E Q + +E T LA++
Sbjct: 1215 LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK 1274
Query: 299 TRALKDEID----VLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNT 354
L+ E+D +L + K++KL +LQD +L LQE N + +
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQEL------LQEENRQKLSLS 1328
Query: 355 VSLEEELKKANAARTQLE-------TYKRQVQDLHVKLSSESKRAD------TLAFEMKR 401
L++ + N+ R QLE ++Q+ LH +++ K+ + A E+KR
Sbjct: 1329 TKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKR 1388
Query: 402 -LEEKHEALLKEKERLIEQRDTLKET----NEELRCSQVQQDHLNQTDAS---ATKSYEN 453
L++ E L + E + D L++T +EL V DH Q+ + K ++
Sbjct: 1389 KLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQ 1448
Query: 454 LAAEIMPVEYREVFIRLQHENKMLRLQQEGSENE-RIEELQEQLEQKHRKMNELETEQRL 512
L AE E I ++ + R + E E E + L LE+ + ELE +
Sbjct: 1449 LLAE-------EKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 513 SKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIE 572
+ + +L +D+ KS+ E K K+ LE +E++ EEL+ + + E
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHE---------LEKSKRALEQQVEEMKTQLEELEDELQATE 1552
Query: 573 DLQPDINQNVQKIN-ELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEI 631
D + + N+Q + + E LQ +DE EE+ K + + R + L+ + S +
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQ---SEEKKKQLVRQVREMEAELEDERKQRSMAV 1609
Query: 632 MLLRK 636
+K
Sbjct: 1610 AARKK 1614
Score = 98.2 bits (243), Expect = 2e-20
Identities = 128/580 (22%), Positives = 250/580 (43%), Gaps = 78/580 (13%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEI-LSSPPNDAVGELE--QQLKRALEELQ 188
E ++ + + EE +H + I L ++ + D+VG LE +++KR L++
Sbjct: 1335 EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDL 1394
Query: 189 EALAEKEELRQRC-EELDMQVTTLQDEKNSLVSENEMMNEK---LDQLDGSFD----DPN 240
E L+++ E + ++L+ T LQ E + L+ + + + L++ FD +
Sbjct: 1395 EGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEK 1454
Query: 241 TVVAK-----------------KYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELE---- 279
T+ AK K LE+ E+ LE +R E+L
Sbjct: 1455 TISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKD 1514
Query: 280 ---KQLIEFQHRNDELTSLAEETRALKDEI-DVLRATSDKANKLESTVEIYRQKLQDLND 335
K + E + L EE + +E+ D L+AT D +LE V + K Q D
Sbjct: 1515 DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE--VNLQAMKAQFERD 1572
Query: 336 LRKQVKTLQETNMMYMHNTVSLEEELKK-------ANAARTQLETYKRQVQDLHVKLSSE 388
L+ + + +E + +E EL+ A AAR +LE ++DL + S
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM---DLKDLEAHIDSA 1629
Query: 389 SKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTL----KETNEELRCSQVQQDHLNQTD 444
+K D ++++L+ + + ++E + R+ + KE ++L+ + + L +
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL 1689
Query: 445 ASATKSY-------ENLAAEIMPV---------EYREVFIRLQHENKMLRLQQEGSE--N 486
A+A ++ + LA EI E R + R+ + L +Q +E N
Sbjct: 1690 AAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 487 ERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKL 546
+R+++ Q++Q + +N + + ++ ++L++Q ++L+ LQE EG SK
Sbjct: 1750 DRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEM----EGTVKSKY 1805
Query: 547 KQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERY 606
K + A K+ ++ E+L + + + + + +K+ ++ LQ DE A E+Y
Sbjct: 1806 KASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDV--LLQVDDERRNA--EQY 1861
Query: 607 KMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIE 646
K +KA +K L +L A E + +R +E
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
Score = 94.0 bits (232), Expect = 4e-19
Identities = 152/677 (22%), Positives = 280/677 (41%), Gaps = 64/677 (9%)
Query: 32 QDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDNWRIKASNVKKVLQGIMSYYHE 91
Q+++Q S A+ ++ Q++ ++ L + K+ + + A+ VK +LQG H+
Sbjct: 1188 QEMRQKHSQ-AVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246
Query: 92 FLGQQISEALIPDLNQI--------TECSDPV-ELGRLLQLILGCAINCEKKQEHIQNIM 142
++ EA + +L TE +D V +L L + G + K +
Sbjct: 1247 ---RKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDF 1303
Query: 143 TLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCE 202
+ ES +QE +++ S V + + + LEE +EA K L ++
Sbjct: 1304 SALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA---KHNLEKQIA 1360
Query: 203 ELDMQVTTL----QDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQ 258
L QV + +D L + E+ + L+G VA Y + +LQ
Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA-YDKLEKTKTRLQ 1419
Query: 259 EENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDV-LRATSDKAN 317
+E L D R LEK+ +F E +++ + +D + R KA
Sbjct: 1420 QELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKAL 1479
Query: 318 KLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAA-RTQLETYKR 376
L +E ++ +L L KQ +T E M + EL+K+ A Q+E K
Sbjct: 1480 SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT 1539
Query: 377 QVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQ 436
Q+++L +L + RLE +A+ + ER ++ RD E ++ QV+
Sbjct: 1540 QLEELEDELQATEDAK-------LRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR 1592
Query: 437 QDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENK--------MLRLQQEGSENER 488
+ D +S A + + ++ +++ + NK + +LQ + + R
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652
Query: 489 I--------EELQEQLEQKHRKMNELETEQRLSKERI-------RELQQQIEDLQKSLQE 533
EE+ Q ++ +K+ +E E +E + R+ QQ+ ++L +
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Query: 534 QGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKIN---ELEA 590
K G + + K++LEA + +L E EE Q ELI D N + +IN LE
Sbjct: 1713 SSGK--GALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLER 1770
Query: 591 ALQKKDEDMKAMEERYKMYLE-KARNVIKTLDPKLNPASAEIMLLRKQLAEKERRI--EI 647
+ +K+E+ + ER L+ K + + T+ K A I L ++A+ E ++ E
Sbjct: 1771 SHAQKNENARQQLERQNKELKVKLQEMEGTVKSKY---KASITALEAKIAQLEEQLDNET 1827
Query: 648 LESECKVAKFRDYEEKL 664
E + + R E+KL
Sbjct: 1828 KERQAACKQVRRTEKKL 1844
Score = 92.0 bits (227), Expect = 2e-18
Identities = 110/566 (19%), Positives = 252/566 (44%), Gaps = 59/566 (10%)
Query: 173 VGELEQQLKRALEELQEALAEKEE-------LRQRCEELDMQVTTLQDE-------KNSL 218
+ EL+ QL + EELQ ALA EE ++ EL+ Q++ LQ++ +N
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130
Query: 219 VSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEEL 278
+ + E+L+ L +D A + +L+ ++ QE N + +++ + H ++
Sbjct: 1131 EKQKRDLGEELEALKTELEDTLDSTAAQQ---ELRSKREQEVNILKKTLEEEAKTHEAQI 1187
Query: 279 EKQLIEFQHRNDELTSLAEETRALKDEIDVLRAT-SDKANKLESTVEIYRQKLQDLNDLR 337
++ + +EL E+T+ +K ++ + T ++ +L + V++ Q D R
Sbjct: 1188 QEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKR 1247
Query: 338 KQVKT-LQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLA 396
K+V+ LQE + + E K + +L+ + K S +K D A
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK--DFSA 1305
Query: 397 FEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAA 456
E +L++ E L +E + + LK+ +E + Q + + + K L A
Sbjct: 1306 LE-SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 457 EIMPVEYR------------EVFIRLQHENKML--RLQQEGSENERIEELQEQLEQK--- 499
++ ++ + EV +LQ + + L R +++ + +++E+ + +L+Q+
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424
Query: 500 ------HRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSK------LK 547
H++ + E++ +++ +L + + + E+ ++E E+ K L
Sbjct: 1425 LLVDLDHQRQSACNLEKK--QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLA 1482
Query: 548 QKLEAHMEKLTEVHEELQKKQELIEDL---QPDINQNVQKINELEAALQKKDEDMKAMEE 604
+ LE ME+ E+ ++ + +EDL + D+ ++V ++ + + AL+++ E+MK E
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE 1542
Query: 605 RYKMYLEKARNVIKTLDPKLNPASAEI---MLLRKQLAEKERRIEILESECKVAKFRDYE 661
+ L+ + L+ L A+ + R + +E++++ + + A+ D
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602
Query: 662 EKLIVSAWYNKSLAFQKLGMESRLVS 687
++ ++ K L +E+ + S
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDS 1628
Score = 92.0 bits (227), Expect = 2e-18
Identities = 116/502 (23%), Positives = 227/502 (45%), Gaps = 45/502 (8%)
Query: 128 AINCEKKQEHIQNIMTLEESVQHVVMT----AIQELMSKEILSSPPNDAVGELEQQLKRA 183
A N EKKQ+ ++ E+++ A E KE + A+ E +Q K
Sbjct: 1436 ACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQ-KAE 1494
Query: 184 LEELQEAL-AEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTV 242
LE L + E E+L +++ V L+ K +L + E M +L++L+ T
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQA--TE 1552
Query: 243 VAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLI--------EFQHRNDELTS 294
AK LQ + Q E R +D+ EE +KQL+ E + + +
Sbjct: 1553 DAKLRLEVNLQAMKAQFE--RDLQGRDE---QSEEKKKQLVRQVREMEAELEDERKQRSM 1607
Query: 295 LAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQ-DLNDLRKQVKTLQETNMMYMHN 353
+ L+ ++ L A D ANK +KLQ + D +++ + + +
Sbjct: 1608 AVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667
Query: 354 TVSLEEELKKANAARTQL-------ETYKRQVQDLHVKLSSE---SKRADTLAFEMKRLE 403
E++LK A QL E KRQ Q +L+ E S LA E KR
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 404 EKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSY----ENLAAEIM 459
E A L+E+ L E++ + N+ L+ + +Q D +N TD + +S+ EN A + +
Sbjct: 1728 EARIAQLEEE--LEEEQGNTELINDRLKKANLQIDQIN-TDLNLERSHAQKNEN-ARQQL 1783
Query: 460 PVEYREVFIRLQHENKMLRLQQEGSENE---RIEELQEQLEQKHRKMNELETEQRLSKER 516
+ +E+ ++LQ ++ + + S +I +L+EQL+ + ++ + R ++++
Sbjct: 1784 ERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKK 1843
Query: 517 IRELQQQIEDLQKSLQEQGSKSEGESS--SKLKQKLEAHMEKLTEVHEELQKKQELIEDL 574
++++ Q++D +++ ++ +++ S+ +LK++LE E+ + +K Q +ED
Sbjct: 1844 LKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903
Query: 575 QPDINQNVQKINELEAALQKKD 596
+ ++++ L+ L++ D
Sbjct: 1904 TETADAMNREVSSLKNKLRRGD 1925
Score = 89.7 bits (221), Expect = 8e-18
Identities = 135/578 (23%), Positives = 245/578 (42%), Gaps = 99/578 (17%)
Query: 144 LEESVQHVVMTAIQE----LMSKEILSSPPNDAVGELEQQLKRALEELQEALA------- 192
L+ S Q M A +E + K++ + + L+ QL +LQE L
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 193 -----------EKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNT 241
+K+EL + C +L+ +V ++ L +E + M + + +L+ ++ +
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957
Query: 242 VVAKKYFH---AQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEF-------QHRNDE 291
K + +L++L+EE LE + LE ++ EF + ++
Sbjct: 958 ARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKS 1017
Query: 292 LTSLAEETRALKDEIDV-LRATSDKANKLESTVEIYRQKLQ-DLNDLRKQVKTLQ----E 345
L L + A+ +++ LR + +LE T R+KL+ D DL Q+ LQ E
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKT----RRKLEGDSTDLSDQIAELQAQIAE 1073
Query: 346 TNMMYMHNTVSL-------EEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFE 398
M L EEE + N A ++ + Q+ +L L SE + +
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 399 MKRLEEKHEALLKEKERLIEQRDTLKET--NEELRCSQVQQDHLNQTDASATKSYENLAA 456
+ L E+ EAL E E DTL T +ELR + Q+ ++ K+ E A
Sbjct: 1134 KRDLGEELEALKTELE------DTLDSTAAQQELRSKREQEVNI------LKKTLEEEAK 1181
Query: 457 EIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHR-KMNELETEQRLSKE 515
HE ++ ++Q+ S + +EEL EQLEQ R K N + +Q L E
Sbjct: 1182 --------------THEAQIQEMRQKHS--QAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Query: 516 RIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIED-- 573
R EL +++ L + +G+S K ++K+EA +++L E ++ + + D
Sbjct: 1226 R-GELANEVKVL--------LQGKGDSEHK-RKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 574 --LQPDINQNVQKINELEAALQKKDEDMKAMEERY---KMYLEKARNVIKTLDPKLNPAS 628
LQ +++ +++ ++ K +D A+E + + L++ +L KL
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335
Query: 629 AEIMLLRKQLAEKERRIEILESECKV--AKFRDYEEKL 664
E R+QL E+E LE + A+ D ++K+
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKM 1373
Score = 86.3 bits (212), Expect = 9e-17
Identities = 112/562 (19%), Positives = 250/562 (44%), Gaps = 100/562 (17%)
Query: 173 VGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEK---- 228
+ ELE+QL+ Q+ EK + ++L+ + L+D+ L E +++ ++
Sbjct: 945 IQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEF 1004
Query: 229 -------------LDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHC 275
L +L + T + ++ + Q ++L++ +LE D
Sbjct: 1005 TTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 276 EELEKQLIEFQ----HRNDELTS---------------------LAEETRALKDEIDVLR 310
EL+ Q+ E + + +EL + L + L+++++ R
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 311 ATSDKANK---------------LESTV-------EIYRQKLQDLNDLRK----QVKT-- 342
A+ +KA K LE T+ E+ ++ Q++N L+K + KT
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Query: 343 --LQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMK 400
+QE + L E+L++ + LE K+ +++ +L++E K + +
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE 1244
Query: 401 RLEEKHEALLKEKERLIEQRDTLK-ETNEELRCSQVQQDH----LNQTDASATKSYENLA 455
+K EA L+E + + + ++ E +++ QV+ D+ L+Q+D+ ++K ++ +
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 456 AEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKE 515
A + + ++ LQ EN+ Q+ S + ++++++++ ++ E E + ++
Sbjct: 1305 A--LESQLQDTQELLQEENR-----QKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 516 RIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEE-------LQKK- 567
+I L Q+ D++K +++ S E++ ++K+KL+ +E L++ HEE L+K
Sbjct: 1358 QIATLHAQVADMKKKMED--SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTK 1415
Query: 568 ---QELIEDLQPDINQNVQKINELEAALQKKDE---DMKAMEERYKMYLEKARNVIKTLD 621
Q+ ++DL D++ Q LE +K D+ + K + +Y ++A + +
Sbjct: 1416 TRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKE 1475
Query: 622 PKLNPASAEIMLLRKQLAEKER 643
K + + +Q AE ER
Sbjct: 1476 TKALSLARALEEAMEQKAELER 1497
Score = 75.9 bits (185), Expect = 1e-13
Identities = 86/381 (22%), Positives = 170/381 (44%), Gaps = 40/381 (10%)
Query: 302 LKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNM---MYMHNTVSLE 358
+K + V R + K E V++ ++L N L +++TLQ M + + + E
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLT-EMETLQSQLMAEKLQLQEQLQAE 892
Query: 359 EEL-KKANAARTQLETYKRQVQ----DLHVKLSSESKRADTLAFEMKRLEEKHEALLK-- 411
EL +A R +L K++++ DL ++ E +R L E K++++ + L +
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 412 EKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQ 471
E+E Q+ L++ E + +++++ + D + + E E E+ +
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE 1012
Query: 472 HENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSL 531
++K L + + I +L+E+L ++ ++ ELE +R + +L QI +LQ +
Sbjct: 1013 EKSKSLA-KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 532 QEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAA 591
E LK +L + EELQ +E+ N ++KI ELE+
Sbjct: 1072 AE------------LKMQL-------AKKEEELQAALARVEEEAAQKNMALKKIRELESQ 1112
Query: 592 LQKKDEDMKA------MEERYKMYLEKARNVIKT-LDPKLNPASAEIMLLRKQLAEKERR 644
+ + ED+++ E+ K L + +KT L+ L+ +A+ L K+ E
Sbjct: 1113 ISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNIL 1172
Query: 645 IEILESECKV--AKFRDYEEK 663
+ LE E K A+ ++ +K
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQK 1193
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 101 bits (251), Expect = 3e-21
Identities = 121/540 (22%), Positives = 235/540 (43%), Gaps = 60/540 (11%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEAL 191
EK +E Q + + + H + A E+ K L + V EL + E+LQ
Sbjct: 1982 EKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLE 2041
Query: 192 AEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPN-------TVVA 244
+ + L EL+ Q+ L EK LV E+E + +L + D ++ N +V
Sbjct: 2042 KDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESD--YEKLNVSKALEAALVE 2099
Query: 245 KKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKD 304
K F L+L QEE +L + RV E EK+ + H ++L E +LKD
Sbjct: 2100 KGEF--ALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQL---HIAEKLKERERENDSLKD 2154
Query: 305 EIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKA 364
+++ L +L+ + E + D + + +V+TL +T + M ++ + E
Sbjct: 2155 KVENLE------RELQMSEENQELVILDAENSKAEVETL-KTQIEEMARSLKVFE--LDL 2205
Query: 365 NAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQ-RDTL 423
R++ E +Q+Q+ +LS K + ++ E+ + +E + +E ++ L
Sbjct: 2206 VTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQL 2265
Query: 424 KETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEG 483
KE NE + Q+ + T+ S P+E +L++ + LR + E
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDP----------PIEEEH---QLRNSIEKLRARLEA 2312
Query: 484 SENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIE-----DLQKSLQEQGSKS 538
E +++ LQ+ E +H L K R+ L++++E +L+ + SK
Sbjct: 2313 DEKKQLCVLQQLKESEH--------HADLLKGRVENLERELEIARTNQEHAALEAENSKG 2364
Query: 539 EGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEA-------A 591
E E+ LK K+E + L + ++ + E+L ++ + ++I+ELE
Sbjct: 2365 EVET---LKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENI 2421
Query: 592 LQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESE 651
LQ+K+++ M+E+ +E + +K L+ ++ + + + ++E LE E
Sbjct: 2422 LQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELE 2481
Score = 91.3 bits (225), Expect = 3e-18
Identities = 137/592 (23%), Positives = 252/592 (42%), Gaps = 103/592 (17%)
Query: 132 EKKQEHIQNIMTLEESVQHV----VMTAIQELMSKEILSSPPNDAVGELEQQLKRALEEL 187
++K E + N M +S H+ +MT I+ + E + VGEL+++ E+L
Sbjct: 1794 DRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKI-------VGELKKENSDLSEKL 1846
Query: 188 QEALAEKEELRQRCE---------ELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFD- 237
+ + +EL QR E E+ ++ +D +++ N+ E+ ++
Sbjct: 1847 EYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSR 1906
Query: 238 --DPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSL 295
+ + + + LE +Q E LE KD+ E +K ++ + +EL+ +
Sbjct: 1907 IRSEKASIEHEALYLEADLEVVQTEKLCLE--KDN-----ENKQKVIVCLE---EELSVV 1956
Query: 296 AEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTV 355
E L+ E+D + S K L+ E ++K Q+L + + +H
Sbjct: 1957 TSERNQLRGELDTM---SKKTTALDQLSEKMKEKTQELESHQSEC----------LHCIQ 2003
Query: 356 SLEEELK-KANAARTQLETYKRQVQD---LHVKLSSESKRADTLAFEMKRLEEKHEALLK 411
E E+K K +T ++D L KL S K + L+ LE + L K
Sbjct: 2004 VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNK 2063
Query: 412 EKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQ 471
EKE L+++ ++L + R S+ + LN + A E + +E +L+
Sbjct: 2064 EKELLVKESESL-----QARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLR 2118
Query: 472 HENKMLRLQQEGSENERI-------------EELQEQLEQKHRKMNELETEQRL------ 512
+ LR++ E E +++ + L++++E R++ E Q L
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAE 2178
Query: 513 -SKERIRELQQQIEDLQKSL-------------QEQGSKSEGESSSKLKQ--KLEAHMEK 556
SK + L+ QIE++ +SL +E +K E +L + KL + +
Sbjct: 2179 NSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKS 2238
Query: 557 LTEVHE--ELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLE--- 611
L E E E+Q K+E ++ NQ ++++NE AAL E MKA E+ +E
Sbjct: 2239 LLEEKEQAEIQIKEESKTAVEMLQNQ-LKELNEAVAALCGDQEIMKATEQSLDPPIEEEH 2297
Query: 612 KARNVIKTLDPKLNPASAEIMLLRKQLAEKER-------RIEILESECKVAK 656
+ RN I+ L +L + + + +QL E E R+E LE E ++A+
Sbjct: 2298 QLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIAR 2349
Score = 88.2 bits (217), Expect = 2e-17
Identities = 125/588 (21%), Positives = 264/588 (44%), Gaps = 81/588 (13%)
Query: 132 EKKQEHIQNIMTLEESVQHV-VMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEA 190
EKKQ + + L+ES H ++ E + +E+ + N LE + + E++
Sbjct: 2314 EKKQLCV--LQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKG--EVETL 2369
Query: 191 LAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLD---GSFDDPNTVVAKKY 247
A+ E + Q L++ V T++ EK +L +E + E++ +L+ SF+ N + K+
Sbjct: 2370 KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE--NILQEKEQ 2427
Query: 248 FHAQLQLE----------QLQEENFRLEAAKDDY------------RVHCEELEK-QLIE 284
Q++ + QL+E N R+ A +D +V C ELEK QL++
Sbjct: 2428 EKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQ 2487
Query: 285 -FQHRNDELTSLAEETRALKDEID----VLRATSDKANKLESTVEIYRQKLQDLNDLRKQ 339
+ L L E++ L ++ ++L++ ++ Q + L+ + +
Sbjct: 2488 GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGE 2547
Query: 340 VKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESK--RADTLAF 397
+ +E N+ + TV LE++++ + L+ +Q + L +E + + D ++F
Sbjct: 2548 HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF 2607
Query: 398 --EMKRLEEKHEALLKEKERLIEQRDTLKE--TNEELRCSQVQQDHLNQTDASATKSYEN 453
++ ++ K L +E + ++ L+E + E+ R + Q L + +S + E
Sbjct: 2608 VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKE- 2666
Query: 454 LAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLS 513
+ +E E+ L +K ++++EG E I E Q +L + +K Q L
Sbjct: 2667 -----LTLENSELKKSLDCMHKD-QVEKEGKVREEIAEYQLRLHEAEKK------HQALL 2714
Query: 514 KERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIED 573
+ ++ + +I+ ++ L SK E SS KL+ L ++ E++ L+ +++E+
Sbjct: 2715 LDTNKQYEVEIQTYREKLT---SKEECLSSQKLEIDLLKSSKE--ELNNSLKATTQILEE 2769
Query: 574 LQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIK--------------- 618
L+ N++ +N+L+ ++ MK + + K LE+ + +++
Sbjct: 2770 LKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQ-LEEEKEILQKELSQLQAAQEKQKT 2828
Query: 619 --TLDPKLNPASAEIMLLRKQLAEKERRI-EILESECKVAKFRDYEEK 663
+D K++ + EI L++ L EK + E L+ C + + EK
Sbjct: 2829 GTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEK 2876
Score = 84.3 bits (207), Expect = 4e-16
Identities = 112/514 (21%), Positives = 230/514 (44%), Gaps = 68/514 (13%)
Query: 166 SSPPN--DAVGELEQQLKRALEELQEALA--EKEELRQ--RCEELDMQVTTLQDEKNSLV 219
SS P+ D + Q+L+ + EL+ L EKE Q + +EL +Q L+ K L+
Sbjct: 274 SSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQ---LEKAKVELI 330
Query: 220 SENEMMNEKLDQL---DGSFDDPNTVVAKKYFHAQLQLEQLQEE----NFRLEAA----- 267
+ +++N+ D+L +D +T KY + +L++L E+ E+A
Sbjct: 331 EKEKVLNKCRDELVRTTAQYDQAST----KYTALEQKLKKLTEDLSCQRQNAESARCSLE 386
Query: 268 ---KDDYRVHCEELEKQLIEFQHRNDELTS----LAEETRALKDEIDVLRATSDKAN--- 317
K+ + EEL +Q FQ + E L +E + K+ +VL+A DK
Sbjct: 387 QKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVK 446
Query: 318 -KLESTVEIYRQKLQDL-----------NDLRKQVKTLQETNMMYMHNTVSLEEELKKAN 365
+LE+ +E ++QKL N+LR+ ++ +++ N + ++ E+
Sbjct: 447 QQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLE 506
Query: 366 AARTQLETYKRQVQDLHVKLSSESKRADTLAFEM-KRLEEKHEALLKEKERLIEQRDTLK 424
A ++ Q Q+ ++ +++ +T+ ++ +++ ++ +L EK +L +
Sbjct: 507 AELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKL-----AVA 561
Query: 425 ETNEELRCSQ----VQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQ 480
+ ++ CSQ ++ H+ Q + +K+ + A + +E ++ E K L
Sbjct: 562 DLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSC 621
Query: 481 QEGSENERIEELQEQLEQKHRKMNELET-------EQRLSKERIRELQQQIEDLQKSLQE 533
+ + + +++ + E K+N LET + ER+R L+ E+L ++
Sbjct: 622 WKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRN 681
Query: 534 QGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQ 593
+ + +S QKL A+ME + QK Q+ IE++ +Q ++ +LE LQ
Sbjct: 682 LHNVLDSKSVEVETQKL-AYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQ 740
Query: 594 KKDEDMKAMEERYK---MYLEKARNVIKTLDPKL 624
++ + Y+ E R+++K+ D L
Sbjct: 741 LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774
Score = 75.1 bits (183), Expect = 2e-13
Identities = 116/549 (21%), Positives = 224/549 (40%), Gaps = 55/549 (10%)
Query: 142 MTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEEL-------QEALAEK 194
M L++ + +E+ + + +S V +LE +L+ E+ Q+ AE
Sbjct: 701 MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY 760
Query: 195 EELRQRCEELDMQVTTLQDEKNSLVSENEM--MNEKLDQLDGSFDDPNTVVAKKYFHAQL 252
E LR + D + T +D + SL++ ++ M+ + G + + +L
Sbjct: 761 ESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGS----MPSERSECRL 816
Query: 253 QLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEET-----RALKDEID 307
+ +Q + + L+ D E ++ + Q + +EL + E +A +
Sbjct: 817 EADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQS 876
Query: 308 VLRATSDKANKLESTVEIYRQKLQD-LNDLRKQVKTLQETNMMYMHNTVSLEEELKKANA 366
+ TS + +KL+ ++ + + L+ L + K LQ N ++E LKK+N
Sbjct: 877 FVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQE-LKKSNH 935
Query: 367 ARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKET 426
LE +++Q L LS E K ++ KR E E L ++ TLKE
Sbjct: 936 L---LEDSLKELQLLSETLSLEKKEMSSIISLNKR----------EIEELTQENGTLKEI 982
Query: 427 NEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSEN 486
N L ++ +++ A+ E +E+ +E I LQ R ++ G+
Sbjct: 983 NASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQ------RCEETGNAY 1036
Query: 487 ERIEELQEQLEQKHRKMNELETE-QRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSK 545
E + + + ++K+ K+ L E L + R EL+Q L+E +K E +K
Sbjct: 1037 EDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ--------LKEAFAKEHQEFLTK 1088
Query: 546 LKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEER 605
L E + + E+ E +Q Q L ++ + N + + L+ + E+ M++
Sbjct: 1089 LAFAEERNQNLMLEL-ETVQ--QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKE 1145
Query: 606 YKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEKLI 665
L++ ++K + K + E +R + E+E ++C D E K I
Sbjct: 1146 VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESE----RNQCNFKPQMDLEVKEI 1201
Query: 666 VSAWYNKSL 674
YN L
Sbjct: 1202 SLDSYNAQL 1210
Score = 69.7 bits (169), Expect = 9e-12
Identities = 113/535 (21%), Positives = 230/535 (42%), Gaps = 83/535 (15%)
Query: 134 KQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGEL-------EQQLKRALEE 186
K E +N+M E+ Q V Q + + +S + V E E++L+ ++
Sbjct: 860 KGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDK 919
Query: 187 LQEALAEKEELRQ-------RCEELDMQVTTLQDEK---NSLVSENEMMNEKLDQLDGSF 236
++ AE +EL++ +EL + TL EK +S++S N+ E+L Q +G+
Sbjct: 920 VETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTL 979
Query: 237 DDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEF--QHRNDELTS 294
+ N L +E L + + + +E EK + E Q++ ++L
Sbjct: 980 KEINA--------------SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1025
Query: 295 L--AEET-RALKDEIDVLRATSDKANKLESTVEIYRQKLQD-LNDLRKQVKTLQETNMMY 350
L EET A +D +A +K +KLE + ++ N+L + + + + +
Sbjct: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
Query: 351 MHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESK-RADTLAFEMKRLEEKHEAL 409
+ EE + +LET ++ ++ + SK A L E+ L+E+ +
Sbjct: 1086 LTKLAFAEE---RNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKM 1142
Query: 410 LKEKERLIEQRDTL-KETNEELRCSQVQQDHLNQT--DASATKSYENLAAEIMPVEYREV 466
KE L+++ + L K + C ++ + + + + + ++ N + M +E +E+
Sbjct: 1143 QKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQ-MDLEVKEI 1201
Query: 467 FIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIED 526
+ S N ++ +L+ L K K+ E E E+ + ++ ++ +E
Sbjct: 1202 SL--------------DSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLE- 1246
Query: 527 LQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKIN 586
+LQ+ S+ E S +++A + ++ H EL Q LQ + + K+N
Sbjct: 1247 -TSNLQDMQSQ---EISGLKDCEIDAEEKYISGPH-ELSTSQNDNAHLQCSLQTTMNKLN 1301
Query: 587 ELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEK 641
ELE K E ++A E+Y++ E LN + +E + +++AE+
Sbjct: 1302 ELE----KICEILQA--EKYELVTE------------LNDSRSECITATRKMAEE 1338
Score = 68.2 bits (165), Expect = 3e-11
Identities = 105/549 (19%), Positives = 226/549 (41%), Gaps = 59/549 (10%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRA---LEELQ 188
++ E +++ ++ + H + ++ +E + + +LEQ+LKR LE Q
Sbjct: 70 QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQ 129
Query: 189 EALAEKEELRQRCEELDMQVTT-LQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKY 247
+A + C TT L + S+ E + EK ++ V +K
Sbjct: 130 QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNK---------EVEERKR 180
Query: 248 FHAQLQLEQLQEENFRLEAAKDDYR-VHCEELEKQLIEFQHRN--DELTSLAEETRALKD 304
A+++ Q ++ + L A ++R + + + +Q L+S ++ T +D
Sbjct: 181 LEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD 240
Query: 305 EIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVS--LEEELK 362
+ + ST++I + ++ N + N+ S L ++LK
Sbjct: 241 FSASYFSGEQEVTPSRSTLQIGK----------------RDANSSFFDNSSSPHLLDQLK 284
Query: 363 KANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDT 422
N + + ++ +L ++L K + ++ + +E L K K LIE+
Sbjct: 285 AQN------QELRNKINELELRLQGHEKE---MKGQVNKFQELQLQLEKAKVELIEKEKV 335
Query: 423 LKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQE 482
L + +EL + Q D A+ Y L ++ + R E+ L+Q+
Sbjct: 336 LNKCRDELVRTTAQYD-------QASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQK 388
Query: 483 GSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGES 542
E E+ E QE+L ++ R L+ E K R+ + QQ +++ LQ + K
Sbjct: 389 IKEKEK--EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLT-SV 445
Query: 543 SSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAM 602
+L+ LE +KL + Q Q +L+ + + ++ N L++ ++K ++ +
Sbjct: 446 KQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHL 505
Query: 603 E---ERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVA---K 656
E + K L +++N + + K + L++++ ++E + + + + VA K
Sbjct: 506 EAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEK 565
Query: 657 FRDYEEKLI 665
RD + L+
Sbjct: 566 QRDCSQDLL 574
Score = 65.9 bits (159), Expect = 1e-10
Identities = 109/540 (20%), Positives = 222/540 (41%), Gaps = 67/540 (12%)
Query: 182 RALEELQEALAE----KEELRQRCEELDMQVTTLQDEK----------NSLVSENEMMNE 227
RAL+++QE + K+E +QR +LD LQ +K +L EN+ + E
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLME 74
Query: 228 KLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQH 287
+ L+ + + + K Q QL ++E + + + ELE+ Q
Sbjct: 75 ICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQS 134
Query: 288 RNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETN 347
+ L + + + S +K E E Y +++++ L +VK LQ
Sbjct: 135 ADVSLNPCNTPQKIFTTPLTPSQYYS--GSKYEDLKEKYNKEVEERKRLEAEVKALQAKK 192
Query: 348 MMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLA-FEMKRLEEKH 406
++ + A + + +++++ H LSS S+R F +
Sbjct: 193 ASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSH--LSSNSQRTPIRRDFSASYFSGEQ 250
Query: 407 EALLKEKERLIEQRDT----------------LKETNEELRCSQVQQDHLNQTDASATKS 450
E I +RD LK N+ELR + + Q K
Sbjct: 251 EVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKG 310
Query: 451 YENLAAEIMPVEYREVFIRLQHENKML-----RLQQEGSENERIEELQEQLEQKHRKMNE 505
N E+ ++ + + L + K+L L + ++ ++ LEQK +K+ E
Sbjct: 311 QVNKFQELQ-LQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTE 369
Query: 506 LETEQRLSKERIR-ELQQQIEDLQKSLQEQGSKSE------GESSSKLKQKLEAHMEKLT 558
+ QR + E R L+Q+I++ +K QE+ S+ + + ++K +L +++
Sbjct: 370 DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAK 429
Query: 559 EVHEELQKKQELIEDLQPDINQNV----QKINELEAALQ----KKDEDMKAMEERYKMYL 610
+H LQ + + + ++ + N+ QK+ E A Q K++E ++MEE +
Sbjct: 430 NMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEE-----M 484
Query: 611 EKARNVIKTLDP----KLNPASAEIMLLRKQLAEKERRIEILESE--CKVAKFRDYEEKL 664
+K N++K+ ++ AE+ +++ L + + E ++++ + RD +EK+
Sbjct: 485 KKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKI 544
Score = 65.1 bits (157), Expect = 2e-10
Identities = 131/612 (21%), Positives = 248/612 (40%), Gaps = 89/612 (14%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMT--AIQELMSKEILSSPPNDA--VGELEQQLKRALEEL 187
++ QE + + EE Q++++ +Q+ + E+ + N G L+Q++ EE
Sbjct: 1080 KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQ 1139
Query: 188 QEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKY 247
+ E +L Q E+L M+V + E +L E+E + + + + + N
Sbjct: 1140 NKMQKEVNDLLQENEQL-MKVMKTKHECQNL--ESEPIRNSVKERESERNQCN------- 1189
Query: 248 FHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEID 307
F Q+ LE E + D Y +LE L +++ +L +E L+ E+
Sbjct: 1190 FKPQMDLEVK-------EISLDSYNAQLVQLEAML---RNKELKLQESEKEKECLQHELQ 1239
Query: 308 VLRATSDKANKLESTVEIYRQKLQDLNDLR-----------KQVKTLQETNMMYMHNTVS 356
+R + +N ++ Q++ L D ++ T Q N H S
Sbjct: 1240 TIRGDLETSN----LQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNA---HLQCS 1292
Query: 357 LEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERL 416
L+ + K N E + + +L +L+ T +++ E+ LL E + L
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITAT---RKMAEEVGKLLNEVKIL 1349
Query: 417 IEQRDTLK-ETNEELRCSQV-----QQDHLNQTDASATKSYENLAAEIMPV-----EYRE 465
+ L E E++ + +Q ++ + SYE+L V E +E
Sbjct: 1350 NDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQE 1409
Query: 466 VFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQR-LSKERIRELQQQI 524
F+ LQ E+K+L Q + ++ ELQ ++ + L T R + ++E+Q +
Sbjct: 1410 KFLSLQSEHKILH-DQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGL 1468
Query: 525 ED-----LQKSLQEQGSK--SEGESS---------------SKLKQKLEAHMEKLTEVHE 562
E+ L S S S G+SS S L+ + A+ + EV
Sbjct: 1469 EEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFC 1528
Query: 563 ELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDP 622
+++ L P + + + ELE+ + + ++ +EE+ + I+ L+
Sbjct: 1529 SSLQEENLTRKETP--SAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQ 1586
Query: 623 KLNPASAEIMLLRKQ-LAEKERRIE-----ILESECKVAKFRDYEEKLIVSAWYNKSLAF 676
L+ E+ LRKQ L+E E+ + LE E K+A + E+L + + L
Sbjct: 1587 LLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVAR-LQL 1645
Query: 677 QKLGMESRLVSG 688
Q L + SR + G
Sbjct: 1646 QGLDLSSRSLLG 1657
Score = 62.4 bits (150), Expect = 1e-09
Identities = 72/332 (21%), Positives = 143/332 (43%), Gaps = 37/332 (11%)
Query: 115 VELGRLLQLILGCAINCEKKQEHIQN-IMTLEESVQHVVMTAIQELMSKEILSSPPNDAV 173
VEL + +Q++ + + E +Q+ LE ++ M + + +++ +
Sbjct: 2563 VELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQ 2622
Query: 174 GELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLD 233
E+ + ++ E +E EK L + L ++ + +D+ L EN + + LD +
Sbjct: 2623 REMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMH 2682
Query: 234 GSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQL-IEFQHRNDEL 292
+ V E++ E RL A+ ++ + KQ +E Q ++L
Sbjct: 2683 KDQVEKEGKVR----------EEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKL 2732
Query: 293 TSLAEETRALKDEIDVLRATSDKANK-LESTVEIYRQ-------KLQDLNDLRKQVKTLQ 344
TS E + K EID+L+++ ++ N L++T +I + L+ +N L+K+ + Q
Sbjct: 2733 TSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQ 2792
Query: 345 ETNMMYMHNTVSLEEE-------LKKANAAR----------TQLETYKRQVQDLHVKLSS 387
+ + + LEEE L + AA+ T+++ ++++L L
Sbjct: 2793 GKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEE 2852
Query: 388 ESKRADTLAFEMKRLEEKHEALLKEKERLIEQ 419
++K AD + L HE L K KE L Q
Sbjct: 2853 KTKEADEYLDKYCSLLISHEKLEKAKEMLETQ 2884
Score = 55.5 bits (132), Expect = 2e-07
Identities = 126/581 (21%), Positives = 236/581 (40%), Gaps = 111/581 (19%)
Query: 110 ECSDPVELGRLLQLILGCAINCEK-KQEHIQNIMTLEESVQHVVMTAIQ-ELMSKEILSS 167
E +D ++ L ++ C+ + E I+N + ES ++ Q +L KEI
Sbjct: 1145 EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLD 1204
Query: 168 PPNDAVGELEQQLKRALEELQEALAEKEELRQRCEEL--DMQVTTLQDEKNSLVSENEMM 225
N + +LE L+ +LQE+ EKE L+ + + D++ + LQD ++ +S +
Sbjct: 1205 SYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG--LK 1262
Query: 226 NEKLDQLDGSFDDPNTVVAKKYFHAQLQL----------------EQLQEENFRLEAAKD 269
+ ++D + P+ + + +A LQ E LQ E + L +
Sbjct: 1263 DCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELN 1322
Query: 270 DYRVHC--------EELEKQLIEFQHRNDELTSLAEET----------RALKDEIDVLRA 311
D R C EE+ K L E + ND+ L E ++ V A
Sbjct: 1323 DSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLA 1382
Query: 312 TSDKANKLE------STVEIYRQKLQD----------------------LNDLRKQVKTL 343
D++N E V+++ +LQ+ +++L+ V +L
Sbjct: 1383 PLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSL 1442
Query: 344 QETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTL---AFEMK 400
+ N++ N + + +L K QL + V L +S +L +F
Sbjct: 1443 KAENLVLSTNLRNFQGDLVK----EMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRA 1498
Query: 401 RLEEKHE-ALLKEKERLIEQRDTLKETNEELRCSQVQQDHLN--QTDASATKSYENLAAE 457
LE+ + +LL E + + +E+ CS +Q+++L +T ++ K E L E
Sbjct: 1499 LLEQTGDMSLLSNLEGAVSANQC---SVDEVFCSSLQEENLTRKETPSAPAKGVEEL--E 1553
Query: 458 IMPVEYREVFIRLQHE--------NKMLRLQQE--GSENERIEELQEQL----EQKHRKM 503
+ YR+ +L+ + NK ++ ++ SE + ++ L++Q EQ +K+
Sbjct: 1554 SLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKL 1613
Query: 504 NE--LETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGES------SSKLKQKLEA--- 552
LE E +L+ E+ + Q +E LQ QG S ++ + E+
Sbjct: 1614 TSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDI 1673
Query: 553 ---HMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEA 590
H + TE + Q +D Q D+N +++KI E A
Sbjct: 1674 SKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGA 1714
Score = 54.3 bits (129), Expect = 4e-07
Identities = 50/195 (25%), Positives = 95/195 (48%), Gaps = 25/195 (12%)
Query: 489 IEELQEQLEQKH-RKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLK 547
+EE +E L + +K+ ELE + K+ ++ Q Q++ L+ +LQ+Q K E E +
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
Query: 548 QKLEAHMEKLTEVHEELQK-KQELIEDLQ---PDINQNVQKINELEAALQKKDEDMKAME 603
K E ++L E+ E L+K KQ++ +LQ +N ++N + ++K ++++K
Sbjct: 65 LKRE--NQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELK--- 119
Query: 604 ERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEK 663
R K LE+++ ++ D LNP + + L + +K+ D +EK
Sbjct: 120 -RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQ--------YYSGSKYEDLKEK 170
Query: 664 LIVSAWYNKSLAFQK 678
YNK + +K
Sbjct: 171 ------YNKEVEERK 179
Score = 50.8 bits (120), Expect = 4e-06
Identities = 112/590 (18%), Positives = 237/590 (40%), Gaps = 92/590 (15%)
Query: 146 ESVQHVVMTAIQELMSK-EILSSPPNDAVGELEQQLKRALEEL----QEALAEKEELRQR 200
ES+ V ++++L K E N + ELEQ L +EL ++ L+E E+ +Q+
Sbjct: 1553 ESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQK 1612
Query: 201 CE----ELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFD-----DPNTVVAKKYFHAQ 251
E++ ++ + + L E E+ +L LD S D + +
Sbjct: 1613 LTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCD 1672
Query: 252 LQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEI----- 306
+ E E R K D C++ +Q + T + T E
Sbjct: 1673 ISKEHTSETTER--TPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTN 1730
Query: 307 ------DVLRATSDKANKLE-----STVEI-YRQKLQDLNDLRKQVKTLQETNMMYMHNT 354
D + +S+ ++L + V + + +D+++L+ +VK N+ +H
Sbjct: 1731 YEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVI 1790
Query: 355 VSLEEELKKANAARTQLETYKRQVQDLHVKLSSES-----KRADTLAFEMKRLEEKHEAL 409
+ +++ +L++ K +Q++ + E+ K L E L EK E
Sbjct: 1791 EDRDRKVESLLNEMKELDS-KLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYF 1849
Query: 410 LKEKERLIEQRDTLKETNE--ELRCSQVQQDHLNQTDASATKSYEN-----------LAA 456
+ + L+++ +T + N E+ + ++ + A S++ + +
Sbjct: 1850 SCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRS 1909
Query: 457 EIMPVEYREVFIRLQHE---NKMLRLQQEGSENERIEE-LQEQLEQKHRKMNELETEQRL 512
E +E+ +++ E + L L+++ +++ L+E+L + N+L E
Sbjct: 1910 EKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDT 1969
Query: 513 SKERIRELQQQIEDLQKSLQE------------QGSKSEGESSSKLKQKLEAHMEKLTEV 560
++ L Q E +++ QE Q +++E + ++L Q L + + +L +
Sbjct: 1970 MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKD 2029
Query: 561 HEELQKK-QELIEDLQP------DINQNVQKINELEAALQKKDEDMKA--MEERYKMYLE 611
LQ+K Q L +D Q ++ + ++N+ + L K+ E ++A E Y+
Sbjct: 2030 KTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKL-- 2087
Query: 612 KARNVIKTLDP----------KLNPASAEIMLLRKQLAEKERRIEILESE 651
NV K L+ +L+ E+ LR+ + + RIE E +
Sbjct: 2088 ---NVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK 2134
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 100 bits (250), Expect = 4e-21
Identities = 121/503 (24%), Positives = 218/503 (43%), Gaps = 68/503 (13%)
Query: 175 ELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMN---EKLDQ 231
ELE+ K+ + LQEA E + +C L+ LQ+E L+ + E N LD+
Sbjct: 1388 ELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDK 1447
Query: 232 LDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDE 291
+FD + +KY Q +LE Q+E+ L EL K ++ D+
Sbjct: 1448 KQRNFDKVLSEWKQKYEETQAELEASQKESRSLST----------ELFKVKNVYEESLDQ 1497
Query: 292 LTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQ-ETNMMY 350
L +L E + L+ EI L + K ++ +L ++KQV+ + E
Sbjct: 1498 LETLRRENKNLQQEISDLTEQIAEGGK----------QIHELEKIKKQVEQEKCEIQAAL 1547
Query: 351 MHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALL 410
SLE E K + +L K +V K++ + + D L R+ E ++ L
Sbjct: 1548 EEAEASLEHEEGKILRIQLELNQVKSEVDR---KIAEKDEEIDQLKRNHTRVVETMQSTL 1604
Query: 411 KEKERLIEQRDTL---KETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVF 467
+ R + D L K+ +L ++Q +H N+ A + ++Y N + +
Sbjct: 1605 DAEIR--SRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQL---- 1658
Query: 468 IRLQHENKMLRLQQEGSENERIEE-----LQEQLEQKHRKMNELETEQRLSKERIRELQQ 522
H + LR Q++ E I E LQ ++E+ + + E ++++++ + + +
Sbjct: 1659 ----HLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASE 1714
Query: 523 QIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKL-TEVHEELQKKQELIEDLQPDINQN 581
+++ L ++ S K+KLE + +L +EV E +Q+ + E + I
Sbjct: 1715 RVQLLH---------TQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDA 1765
Query: 582 VQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLL---RKQL 638
EL KK++D A ER K LE+ +K L +L+ AE + L +KQ+
Sbjct: 1766 AMMAEEL-----KKEQDTSAHLERMKKNLEQ---TVKDLQHRLD--EAEQLALKGGKKQI 1815
Query: 639 AEKERRIEILESECKVAKFRDYE 661
+ E R+ LE E + + R+ E
Sbjct: 1816 QKLEARVRELEGEVENEQKRNAE 1838
Score = 94.4 bits (233), Expect = 3e-19
Identities = 119/514 (23%), Positives = 231/514 (44%), Gaps = 69/514 (13%)
Query: 175 ELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDG 234
E E+++ EE Q+ E + + +EL+ ++ TL EKN L + ++ +E
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDL--QLQVQSE------- 897
Query: 235 SFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTS 294
A A+ + EQL + +LEA +E+ ++ E + N ELT+
Sbjct: 898 ---------ADSLADAEERCEQLIKNKIQLEA-------KIKEVTERAEEEEEINAELTA 941
Query: 295 ----LAEETRALKDEIDVLRATSDKANK----LESTVEIYRQKLQDLND----LRKQVKT 342
L +E LK +ID L T K K E+ V+ +++ L++ L K+ K
Sbjct: 942 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKA 1001
Query: 343 LQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRL 402
LQET+ + + + E+++ A+T+LE +QV DL L E K L +++R
Sbjct: 1002 LQETHQQTLDDLQAEEDKVNILTKAKTKLE---QQVDDLEGSLEQEKK----LRMDLERA 1054
Query: 403 EEKHEALLK-EKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEI-MP 460
+ K E LK +E ++ + ++ +E+L + + +L +K + A EI +
Sbjct: 1055 KRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNL------ISKIEDEQAVEIQLQ 1108
Query: 461 VEYREVFIRLQ------HENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSK 514
+ +E+ R++ + R + E ++ EL+E E+ + L+K
Sbjct: 1109 KKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNK 1168
Query: 515 ERIRELQQQIEDLQK-SLQEQG-----SKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQ 568
+R E Q+ DL++ +LQ + K +S ++L +++ + L V ++L+K++
Sbjct: 1169 KREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQI----DNLQRVKQKLEKEK 1224
Query: 569 ELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPAS 628
++ D++ N + I++ + L+K ++ K E+ + +I L +
Sbjct: 1225 SELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQ 1284
Query: 629 AEIMLLRKQLAEKERRIEILESECKVAKFRDYEE 662
E +QL EK+ + L S K A + EE
Sbjct: 1285 TEAGEYSRQLDEKDALVSQL-SRSKQASTQQIEE 1317
Score = 84.3 bits (207), Expect = 4e-16
Identities = 109/547 (19%), Positives = 231/547 (42%), Gaps = 59/547 (10%)
Query: 136 EHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKE 195
E I + ++++Q + +L ++E + A +LEQQ+ ++L+ +L +++
Sbjct: 990 ETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQV----DDLEGSLEQEK 1045
Query: 196 ELRQRCE----ELDMQVTTLQDEKNSLVSENEMMNEKLDQ-------LDGSFDDPNTV-- 242
+LR E +L+ + Q+ + ++ + ++EKL++ L +D V
Sbjct: 1046 KLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEI 1105
Query: 243 -VAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDEL----TSLAE 297
+ KK Q ++E+L EE A++ +L ++L E R +E ++ E
Sbjct: 1106 QLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVE 1165
Query: 298 ETRALKDEIDVLRATSDKAN-KLESTVEIYRQKLQD--------LNDLRKQVKTLQETNM 348
+ + E LR ++A + E+ V R+K D +++L++ + L++
Sbjct: 1166 LNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKS 1225
Query: 349 MYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEA 408
T L + + A+ LE R ++D +L ++ + L ++ + +
Sbjct: 1226 ELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQT 1285
Query: 409 LLKEKERLIEQRDTL-KETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVF 467
E R ++++D L + + + S Q + L TK+ LA +
Sbjct: 1286 EAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSS------ 1339
Query: 468 IRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSK-ERIRELQQQIED 526
+H+ +LR Q E E E ELQ L + + ++ + T+ +R EL++ +
Sbjct: 1340 ---RHDCDLLREQYE-EEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1395
Query: 527 LQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKIN 586
L + LQE E H+E + L+K ++ +++ D+ +V++ N
Sbjct: 1396 LAQRLQEA----------------EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSN 1439
Query: 587 ELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIE 646
AAL KK + + +K E+ + ++ + S E+ ++ E ++E
Sbjct: 1440 AACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLE 1499
Query: 647 ILESECK 653
L E K
Sbjct: 1500 TLRRENK 1506
Score = 75.9 bits (185), Expect = 1e-13
Identities = 114/548 (20%), Positives = 238/548 (43%), Gaps = 71/548 (12%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKR--ALEELQE 189
E K++ Q + EE V+ V +K+ L + D + ++E+ AL++ Q
Sbjct: 1391 EAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQR 1450
Query: 190 ALAEK-EELRQRCEELDMQVTTLQDEKNSLVSE----NEMMNEKLDQLDG---------- 234
+ E +Q+ EE ++ Q E SL +E + E LDQL+
Sbjct: 1451 NFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQ 1510
Query: 235 SFDDPNTVVAK--KYFHAQLQLE-QLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDE 291
D +A+ K H +++ Q+++E ++AA ++ E E +++ Q ++
Sbjct: 1511 EISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQ 1570
Query: 292 LTSLAEETRALKDE------------IDVLRATSDKANKLESTVEIYRQKLQ-DLNDLRK 338
+ S + A KDE ++ +++T D + + ++K++ DLN++
Sbjct: 1571 VKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEI 1630
Query: 339 QVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFE 398
Q+ + N + + LK+ + L+ R +DL +L+ +RA+ L E
Sbjct: 1631 QLNHANRLAAESLRNYRNTQGILKET---QLHLDDALRGQEDLKEQLAIVERRANLLQAE 1687
Query: 399 MKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEI 458
++ L E E+ R I +++ L + +E ++ Q L T L +E+
Sbjct: 1688 IEELWATLEQT--ERSRKIAEQELL-DASERVQLLHTQNTSLINTKKKLENDVSQLQSEV 1744
Query: 459 MPV-----EYREVFIRLQHENKML--RLQQEGSENERIEELQEQLEQKHRKM-NELETEQ 510
V E + + M+ L++E + +E +++ LEQ + + + L+ +
Sbjct: 1745 EEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1804
Query: 511 RLS----KERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQK 566
+L+ K++I++L+ ++ +L+ ++ + K E+ L+ K E +++LT EE +K
Sbjct: 1805 QLALKGGKKQIQKLEARVRELEGEVENE-QKRNAEAVKGLR-KHERRVKELTYQTEEDRK 1862
Query: 567 K----QELIEDLQPDI--------------NQNVQKINELEAALQKKDEDMKAMEERYKM 608
Q+L++ LQ + N N+ K +L+ L++ +E E +
Sbjct: 1863 NVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNK 1922
Query: 609 YLEKARNV 616
K+R V
Sbjct: 1923 LRVKSREV 1930
Score = 66.6 bits (161), Expect = 8e-11
Identities = 82/354 (23%), Positives = 155/354 (43%), Gaps = 55/354 (15%)
Query: 361 LKKANAARTQLETYKRQVQDLHVKLS-SESKRADTLAFEMKRLEEKHEALLKEKERLIEQ 419
L K+ ++ T K + Q +L+ SE+KR K LEEK LLKEK L Q
Sbjct: 842 LLKSAETEKEMATMKEEFQKTKDELAKSEAKR--------KELEEKMVTLLKEKNDLQLQ 893
Query: 420 ----RDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHE-- 473
D+L + E RC Q+ ++ + + + +EV R + E
Sbjct: 894 VQSEADSLADAEE--RCEQLIKNKIQ-----------------LEAKIKEVTERAEEEEE 934
Query: 474 -NKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQ 532
N L ++ E+E EL++ ++ + ++E E+ ++ +++ L +++ L +++
Sbjct: 935 INAELTAKKRKLEDE-CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIA 993
Query: 533 EQGSKSEG--ESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEA 590
+ + + E+ + L+A +K+ + + K ++ ++DL+ + Q + +LE
Sbjct: 994 KLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLER 1053
Query: 591 ALQKKDEDMKAMEE----------RYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAE 640
A +K + D+K +E + LEK I L K+ A + L+K++ E
Sbjct: 1054 AKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKE 1113
Query: 641 KERRIEILESECKVAK-FRDYEEKLIVSAWYNKSLAFQKLGMESRLVSGGGACS 693
+ RIE L E + + R EK L+ + + RL GGA S
Sbjct: 1114 LQARIEELGEEIEAERASRAKAEK------QRSDLSRELEEISERLEEAGGATS 1161
Score = 55.5 bits (132), Expect = 2e-07
Identities = 80/382 (20%), Positives = 156/382 (40%), Gaps = 24/382 (6%)
Query: 176 LEQQLKRALEELQEALAEKEE-----LRQRCEELDMQVTTLQDE---KNSLVSENEMMNE 227
++ +L + E+ +AEK+E R ++ +TL E +N + + M
Sbjct: 1564 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEG 1623
Query: 228 KLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQH 287
L++++ + N + A+ + + L+E L DD E+L++QL +
Sbjct: 1624 DLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHL----DDALRGQEDLKEQLAIVER 1679
Query: 288 RNDELTSLAEETRALKDEIDVLR--ATSDKANKLESTVEIYRQKLQDLNDLRK---QVKT 342
R + L + EE A ++ + R A + + E ++ Q +N +K V
Sbjct: 1680 RANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQ 1739
Query: 343 LQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMK-R 401
LQ + + + EE+ KKA + ++ QD L K + +++ R
Sbjct: 1740 LQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1799
Query: 402 LEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEI--M 459
L+E + LK ++ I++ L+ EL + N + +E E+
Sbjct: 1800 LDEAEQLALKGGKKQIQK---LEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQ 1856
Query: 460 PVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRE 519
E R+ +RLQ L+ + + S + EE +EQ K +L+ E ++ER
Sbjct: 1857 TEEDRKNVLRLQDLVDKLQAKVK-SYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADI 1915
Query: 520 LQQQIEDLQKSLQEQGSKSEGE 541
+ Q+ L+ +E +K E
Sbjct: 1916 AESQVNKLRVKSREVHTKISAE 1937
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 100 bits (249), Expect = 5e-21
Identities = 125/587 (21%), Positives = 256/587 (43%), Gaps = 110/587 (18%)
Query: 176 LEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGS 235
L Q+++ E L + AEK ++ ++L Q++ Q+EK+ + + +L +L +
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 236 FDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIE----------- 284
+ + A+LQ + Q E L+AAK++ E L+ ++E
Sbjct: 1322 MAS----LQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGIL 1377
Query: 285 ----------FQHRNDELTSLAEETRALKD--EIDVLRATSDKAN---------KLESTV 323
+ +N+E+ S E +AL++ E+ V + + + N + E V
Sbjct: 1378 EEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEV 1437
Query: 324 EIYRQKLQDLNDLRKQVKTLQET---NMMYMHNTVSLEEE-LKKANAARTQLETYKRQVQ 379
E R ++Q+L R+ K E ++ + V L++E +++ R+ LE VQ
Sbjct: 1438 ETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ 1497
Query: 380 DLHVKLSSESKRADTLAF--EMKRLEEKHEAL-LKEKERLIEQRD--------------- 421
+ KL+ + ++ L E +R +H+ L L++K+++IE +
Sbjct: 1498 EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLEC 1557
Query: 422 ---TLKETNEELRCSQ-----------VQQDHLNQTDASATKSYENLAAEIMPVEYREVF 467
L+E + ++ C Q Q+ L + + L A+ + E
Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617
Query: 468 IRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQ---- 523
+ R Q+ S+ E+IEELQ Q E + + + E L KERI+ L+ Q
Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQ 1677
Query: 524 -------IEDLQKSLQEQGSK------------SEGESSSKLKQKLEAHMEK-LTEVHEE 563
+E ++ SL+E+G + EG+ SK ++ HM+ L + +E
Sbjct: 1678 TKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKE 1737
Query: 564 LQKKQELIEDLQP---DINQNVQ----KINELEAALQKKDEDMKAMEERYKMYLEKARNV 616
++ +QE I +LQ + Q +Q K+ E L ++++++ ++++ + E+
Sbjct: 1738 VECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELK 1797
Query: 617 IKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEK 663
++L +L+ A ++ LA++++ +E L+ E + A+ ++ K
Sbjct: 1798 EQSLQSQLDEA-------QRALAQRDQELEALQQEQQQAQGQEERVK 1837
Score = 97.4 bits (241), Expect = 4e-20
Identities = 128/511 (25%), Positives = 221/511 (43%), Gaps = 68/511 (13%)
Query: 174 GELEQQLKRALEE----LQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKL 229
GEL+ +AL+E L + LAE+EE +V TL+ + L + EM L
Sbjct: 1409 GELKVAQGKALQENLALLTQTLAEREE----------EVETLRGQIQELEKQREMQKAAL 1458
Query: 230 DQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRN 289
+ L S D + K+ LQ EQ+QE LE + LE + Q R
Sbjct: 1459 ELL--SLD-----LKKRNQEVDLQQEQIQE----LEKCRS-------VLEHLPMAVQERE 1500
Query: 290 DELTSLAEETRALKDEIDVLRATSD-KANKLESTVEIYRQKLQDLNDLRKQVKTLQETNM 348
+LT E+ R L+ + + R + + +LE ++ + + DL+KQ+ TL+ +
Sbjct: 1501 QKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL 1560
Query: 349 MYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEA 408
N +E + K Q ET + + L + L S+ + ++ LE
Sbjct: 1561 ELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTV 1620
Query: 409 LLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQ----TDASATKSYENL---------A 455
L +E L E+ +K E++ Q Q++HL Q D E +
Sbjct: 1621 LARE---LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQ 1677
Query: 456 AEIMPVEYREVFIRLQHENKML----RLQQEGSENERIEELQEQLEQKHRK--MNELETE 509
+I+ + ++ + L+ + L +L QE +E + ++ +H K + + E E
Sbjct: 1678 TKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKE 1737
Query: 510 QRLSKERIRELQQQIEDLQKSLQEQGSKSEGESS---SKLKQKLEAHMEKLTEVHEELQ- 565
+E I ELQ+ + L++ LQ K GE+S S+ +Q++ ++L E E+ +
Sbjct: 1738 VECQQEHIHELQELKDQLEQQLQGLHRK-VGETSLLLSQREQEIVVLQQQLQEAREQGEL 1796
Query: 566 KKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKM-------YLEKARNVIK 618
K+Q L L Q+ ELE ALQ++ + + EER K LE+A +K
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELE-ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855
Query: 619 TLDPKLNPASAEIMLLRKQLAEKERRIEILE 649
+L + L ++LA + RR++ LE
Sbjct: 1856 ERHGELQDHKEQARRLEEELAVEGRRVQALE 1886
Score = 92.4 bits (228), Expect = 1e-18
Identities = 107/491 (21%), Positives = 211/491 (42%), Gaps = 64/491 (13%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEE----L 187
E +QEHI + L++ ++ + +++ +L S + L+QQL+ A E+
Sbjct: 1739 ECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE 1798
Query: 188 QEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKY 247
Q ++ +E ++ + D ++ LQ E+ + E + EK D L G+ + + + ++
Sbjct: 1799 QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER- 1857
Query: 248 FHAQLQ---------LEQLQEENFRLEAAKD---DYRVHCEELEKQLIEFQHRNDELTSL 295
H +LQ E+L E R++A ++ D R E EK L+ Q + E
Sbjct: 1858 -HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
Query: 296 AE-ETRALKD--------------EIDVLRATSDKANKLESTVEIYRQKLQD-------- 332
E ETRAL+D E++ LRA S + E + LQ+
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAA 1976
Query: 333 LNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKR----QVQDLHVKLSSE 388
L + + E + +T +L+ L A QLE R ++QD ++ +
Sbjct: 1977 LQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQED 2036
Query: 389 SKRADTLAF----EMKRLEEKHEALLKE-----KERLIEQRDTLKETNEELRCSQVQQDH 439
++ E++ +E+ + L K +E +I+++ L + EE + Q
Sbjct: 2037 VQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSV 2096
Query: 440 LNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQK 499
A K E L E+ + R L H +K +++ ++ +++ L+ +L+
Sbjct: 2097 RELQLTLAQKEQEIL--ELRETQQRNNLEALPHSHKTSPMEE---QSLKLDSLEPRLQ-- 2149
Query: 500 HRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTE 559
R++ L+ R ++ R E +++ +DL SL + +K+ S ++ L+A + +
Sbjct: 2150 -RELERLQAALRQTEAREIEWREKAQDLALSLAQ--TKASVSSLQEVAMFLQASVLERDS 2206
Query: 560 VHEELQKKQEL 570
+ LQ + EL
Sbjct: 2207 EQQRLQDELEL 2217
Score = 86.7 bits (213), Expect = 7e-17
Identities = 129/624 (20%), Positives = 259/624 (41%), Gaps = 100/624 (16%)
Query: 71 WRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAIN 130
WR++ NV+ LQG + + Q+ + + ++ E +E + L +
Sbjct: 487 WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR 546
Query: 131 CEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEA 190
+ H++ + +E + A E E+ SS E LK + +L+ A
Sbjct: 547 EALESSHLEGELLRQEQTEVTAALARAEQSIAELSSS---------ENTLKTEVADLRAA 597
Query: 191 LAEKEELRQRCE----ELDMQVTTLQDEKNSLVSENEMMNEKLDQLD---GSFDDPNTVV 243
+ L + L+ Q+ L++E S+ S E + + L + +
Sbjct: 598 AVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREAL 657
Query: 244 AKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALK 303
+K H + QL++ +E L+A D + EE++K+L E +H+ + T+ E+
Sbjct: 658 WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQ----- 712
Query: 304 DEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKK 363
L ++ K +E + V +E L +
Sbjct: 713 --------------------------------LHQEAKRQEEV----LARAVQEKEALVR 736
Query: 364 ANAA-RTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDT 422
AA +L+ +R QDL +L S + L + ++++ + K +L Q T
Sbjct: 737 EKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796
Query: 423 LKETNE----ELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQ-----HE 473
+ + E E+RC +++ D T+ S + + AA + +E L+ HE
Sbjct: 797 VTQAKEVIQGEVRCLKLELD----TERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHE 852
Query: 474 NKMLRLQQEGSENERI---EELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKS 530
++ +L+++ E ER +EL + LE R+ ELE R++E Q ++E +Q
Sbjct: 853 KEVNQLREKW-EKERSWHQQELAKALESLEREKMELEM-------RLKEQQTEMEAIQAQ 904
Query: 531 LQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQEL------IEDLQPDINQNVQK 584
+E+ +++E S+ + +LE E+++ + LQ ++EL +E L+ D+ VQK
Sbjct: 905 REEERTQAE---SALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM--KVQK 959
Query: 585 INE------LEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQL 638
+ E L+ LQ+ ++K +++ L + +L ++ L+ QL
Sbjct: 960 LKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQL 1019
Query: 639 AEKERRIEILESECKVAKFRDYEE 662
++ ++E E + K R+ +E
Sbjct: 1020 VAQDDSQRLVEQEVQ-EKLRETQE 1042
Score = 85.1 bits (209), Expect = 2e-16
Identities = 105/494 (21%), Positives = 215/494 (43%), Gaps = 32/494 (6%)
Query: 175 ELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDG 234
E++++L + + + A + E+L Q + + + EK +LV E + +L ++
Sbjct: 691 EIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVER 750
Query: 235 SFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTS 294
D +A++ E L+ F + V +LE Q+ + +
Sbjct: 751 DRQD----LAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806
Query: 295 LAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNT 354
E R LK E+D R+ +++ ++ Q Q+ +Q K E + +
Sbjct: 807 ---EVRCLKLELDTERSQAEQER--DAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREK 861
Query: 355 VSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEA------ 408
E + A+ LE+ +R+ +L ++L + + A + +R EE+ +A
Sbjct: 862 WEKERSWHQQELAKA-LESLEREKMELEMRLKEQQTEME--AIQAQREEERTQAESALCQ 918
Query: 409 --LLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREV 466
L EKER + +TL +T +EL + Q + L Q D K E I+ + +E
Sbjct: 919 MQLETEKER-VSLLETLLQTQKELADASQQLERLRQ-DMKVQKLKEQETTGILQTQLQEA 976
Query: 467 FIRL-----QHENKMLRLQQEGSENERIE-ELQEQLEQKHRKMNELETEQRLSKERIREL 520
L QH + + LQ+E S + + +LQ+Q+E ++ + QRL ++ ++E
Sbjct: 977 QRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEK 1036
Query: 521 QQQIED---LQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPD 577
++ ++ +QK L+ + + S S + +Q+L E + +EL ++ +++ Q +
Sbjct: 1037 LRETQEYNRIQKELEREKA-SLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGE 1095
Query: 578 INQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQ 637
+ ++ L +++K+ D A E + LE + + L L A+ L+ +
Sbjct: 1096 QKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLR 1155
Query: 638 LAEKERRIEILESE 651
L E ++E L +E
Sbjct: 1156 LRSTESQLEALAAE 1169
Score = 83.6 bits (205), Expect = 6e-16
Identities = 140/664 (21%), Positives = 289/664 (43%), Gaps = 109/664 (16%)
Query: 60 LSRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGR 119
++++ + GDN + S + L+ S + +F Q +AL + +T V+
Sbjct: 348 ITQVMVEEGDNIA-QGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQ--D 404
Query: 120 LLQLILGC--AINCEKKQEHIQNIMTLEESVQHVVMTAIQELMS-KEILSSPPNDAVGEL 176
L Q + GC A+N +Q+H Q E + +Q+L ++ L+ D GE+
Sbjct: 405 LRQQLAGCQEAVNL-LQQQHDQ-----WEEEGKALRQRLQKLTGERDTLAGQTVDLQGEV 458
Query: 177 EQQLKRALEELQEALAEKEELRQRCEELDMQVTTL---------------------QDEK 215
+ L + E LQ+A +EELRQ+ E L+ + L Q+E
Sbjct: 459 DS-LSKERELLQKA---REELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL 514
Query: 216 NSLVSENEMMNEKLDQLDGSFDDPNT---VVAKKYFHAQLQLEQLQEENFRLEAA----- 267
+ V E E + E L L+ + + + + + L+ E L++E + AA
Sbjct: 515 HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAE 574
Query: 268 ---------KDDYRVHCEELEKQLIEFQHRNDEL----TSLAEETRALKDEIDVLRATSD 314
++ + +L ++ N+ L L ++ L++E + + +
Sbjct: 575 QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRME 634
Query: 315 KANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETY 374
A + + +++ DL + K+ + L E N LE +L+KA A +L+
Sbjct: 635 AAEQARNALQV------DLAEAEKRREALWEKN-------THLEAQLQKAEEAGAELQAD 681
Query: 375 KRQVQ----DLHVKLS-------SESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTL 423
R +Q ++ KLS + + + + L E KR EE ++EKE L+ ++ L
Sbjct: 682 LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAAL 741
Query: 424 KETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEG 483
E+R V++D ++LA ++ + + + E+ + QQ+
Sbjct: 742 -----EVRLQAVERDR------------QDLAEQLQGLSSAKELL----ESSLFEAQQQN 780
Query: 484 SENERIE-ELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGES 542
S E + +L+ Q++ + ++ E R K + + Q E + + Q +++E E
Sbjct: 781 SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEG 840
Query: 543 SSKLKQKLEAHMEKLTEVHEELQKKQEL-IEDLQPDINQNVQKINELEAALQKKDEDMKA 601
+ L+Q+ AH +++ ++ E+ +K++ ++L + ++ ELE L+++ +M+A
Sbjct: 841 KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEA 900
Query: 602 ME---ERYKMYLEKARNVIKTLDPKLNPASAEIML-LRKQLAEKERRIEILESECKVAKF 657
++ E + E A ++ K + E +L +K+LA+ +++E L + KV K
Sbjct: 901 IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960
Query: 658 RDYE 661
++ E
Sbjct: 961 KEQE 964
Score = 82.0 bits (201), Expect = 2e-15
Identities = 117/516 (22%), Positives = 225/516 (43%), Gaps = 82/516 (15%)
Query: 175 ELEQQLKRALEELQEALAEKEELRQ----RCEELDMQVTTLQDEKNSLVSENEMMNEKLD 230
E +Q++K E+++E +KE L Q R +EL +Q +Q ++ + +++ E L+
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Query: 231 QLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRND 290
Q+ S + + + QL +E R E K + LE + + +
Sbjct: 1687 QIKLSLRERGRELTTQ--------RQLMQE--RAEEGKGPSKAQRGSLEHMKLILRDKEK 1736
Query: 291 ELTSLAE---ETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETN 347
E+ E E + LKD+++ + K+ T + Q+ Q++ L++Q++ +E
Sbjct: 1737 EVECQQEHIHELQELKDQLE--QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794
Query: 348 MMYMHNTVSLEEELKKANAARTQ-LETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKH 406
+ + S +E ++A A R Q LE +++ Q + ++AD L LE+ H
Sbjct: 1795 ELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADAL---QGALEQAH 1851
Query: 407 EALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREV 466
TLKE + EL QDH Q A + E LA E V+ E
Sbjct: 1852 M--------------TLKERHGEL------QDHKEQ----ARRLEEELAVEGRRVQALEE 1887
Query: 467 FI------RLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIREL 520
+ + E +L LQQ+ +E + E++ + L+ ++ ++E
Sbjct: 1888 VLGDLRAESREQEKALLALQQQCAEQAQEHEVETR---------ALQDSWLQAQAVLKER 1938
Query: 521 QQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQ-KKQELIED------ 573
Q++E L+ + Q S+ + E++ + + EA E L + H LQ K+Q L+E
Sbjct: 1939 DQELEALR--AESQSSRHQEEAA---RARAEALQEALGKAHAALQGKEQHLLEQAELSRS 1993
Query: 574 -------LQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNP 626
LQ ++ +LE AL+ ++ +++ + RY+ +++ + + D +L
Sbjct: 1994 LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRH 2053
Query: 627 ASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEE 662
LL K LA++ + I E + + + R+ EE
Sbjct: 2054 QQEREQLLEKSLAQRVQENMIQEKQ-NLGQEREEEE 2088
Score = 81.6 bits (200), Expect = 2e-15
Identities = 126/568 (22%), Positives = 234/568 (41%), Gaps = 67/568 (11%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEAL 191
++K Q +++ ++ + LM KE +A +Q+L +++QEA
Sbjct: 1034 QEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQ 1093
Query: 192 AEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFH-- 249
E++EL + E L +V + E + L E ++ L++L+ S + A +
Sbjct: 1094 GEQKELSAQMELLRQEVK--EKEADFLAQEAQL----LEELEASHITEQQLRASLWAQEA 1147
Query: 250 --AQLQLEQLQEENFRLEA-AKDDYRVHCEELEKQLIE-FQHRNDELTSLAEETRALKDE 305
AQLQL +L+ +LEA A + + + + QL + L S+ E L
Sbjct: 1148 KAAQLQL-RLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206
Query: 306 IDV------LRATSDKANKLES-----TVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNT 354
D L + A L T L+ L + + Q+T +
Sbjct: 1207 GDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQV 1266
Query: 355 VSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKE 414
LEE L A ++Q+ T ++QDL +LS + E + E K +L E
Sbjct: 1267 QKLEERLTDTEAEKSQVHT---ELQDLQRQLSQNQE-------EKSKWEGKQNSLESE-- 1314
Query: 415 RLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHE- 473
L+E +T+ LR +++Q+ + ENL A++ ++ V R Q
Sbjct: 1315 -LMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASA 1373
Query: 474 -----------NKMLRLQQEG--SENERIEELQEQLEQKHRKMNELETEQRLSKERIREL 520
L+L+ E SE ER + LQEQ E K + L+ L + + E
Sbjct: 1374 AGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAER 1433
Query: 521 QQQIEDLQKSLQEQGSKSEGESSS---------KLKQKLEAHMEKLTEVHEELQKKQELI 571
++++E L+ +QE + E + ++ K Q+++ E++ +EL+K + ++
Sbjct: 1434 EEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQI----QELEKCRSVL 1489
Query: 572 EDLQPDINQNVQKI---NELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPAS 628
E L + + QK+ E L+K E + + E + LEK +I++ ++
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLK 1549
Query: 629 AEIMLLRKQLAEKERRIEILESECKVAK 656
+++ L E E +E + K+ K
Sbjct: 1550 KQLVTLECLALELEENHHKMECQQKLIK 1577
Score = 66.6 bits (161), Expect = 8e-11
Identities = 97/419 (23%), Positives = 195/419 (46%), Gaps = 50/419 (11%)
Query: 253 QLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRAT 312
+L QL+ + LE A+ RV EL L + Q +N++ + +AL++ +++L
Sbjct: 266 ELIQLKSQG-DLEKAELQDRV--TELSALLTQSQKQNEDYEKMI---KALRETVEILE-- 317
Query: 313 SDKANKLESTVEIYRQKLQDLNDLRKQVKTLQET---------------NMMYMHNTVSL 357
++ +E + R ++ L++ +K + + N + + +++
Sbjct: 318 TNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFS 377
Query: 358 EEELKKANAARTQLE---TYKRQ-VQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEK 413
+ + + A+ A T + T +RQ VQDL +L+ + + L + + EE+ +AL +
Sbjct: 378 QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRL 437
Query: 414 ERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHE 473
++L +RDTL +L Q + D L++ K+ E L ++ +E +E + RL+
Sbjct: 438 QKLTGERDTLAGQTVDL---QGEVDSLSKERELLQKAREELRQQLEVLE-QEAW-RLRRV 492
Query: 474 NKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQ-KSLQ 532
N L+LQ + ++ ++ +EQ E+ H + E +ER++E+ +E Q +SL
Sbjct: 493 NVELQLQGDSAQGQK----EEQQEELHLAVRE--------RERLQEMLMGLEAKQSESLS 540
Query: 533 EQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAA- 591
E + E SS L+ +L ++ TEV L + ++ I +L N ++ +L AA
Sbjct: 541 ELITLREALESSHLEGEL--LRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAA 598
Query: 592 --LQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEIL 648
L +E + + L + +++ ++ A L+ LAE E+R E L
Sbjct: 599 VKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREAL 657
Score = 56.2 bits (134), Expect = 1e-07
Identities = 111/555 (20%), Positives = 230/555 (41%), Gaps = 89/555 (16%)
Query: 138 IQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDA----VGELEQQLKRALEELQEALAE 193
IQ + +E +Q V EL ++ + DA + + EQ+ K ALE Q+ A
Sbjct: 794 IQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE--QQKAAH 851
Query: 194 KEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQ 253
++E+ Q E+ + + + Q E + + L+ L+ ++ +++
Sbjct: 852 EKEVNQLREKWEKERSWHQQE----------LAKALESLE-----------REKMELEMR 890
Query: 254 LEQLQEENFRLEAAKDDYRVHCEEL--EKQLIEFQHRNDELTSLAEETRALKDEIDVLRA 311
L++ Q E ++A +++ R E + QL + R L +L + + L D
Sbjct: 891 LKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD------- 943
Query: 312 TSDKANKLESTVEIYRQKLQDLN-----DLRKQVKTLQETNMMYMHNTVSLEEELKKANA 366
S + +L +++ + K Q+ L++ + L+E + + +L+EE
Sbjct: 944 ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
Query: 367 ARTQLETYKRQVQDLHVKLSSESKRADTLAFEMK-RLEEKHEALLKEKERLIEQRD-TLK 424
+ L+ +QV+DL +L ++ + E++ +L E E +KE E+ TL
Sbjct: 1004 DKMDLQ---KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLS 1060
Query: 425 ETNEELRCSQVQQ-DHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEG 483
+E R +Q+ D + Q + SA + A E +E+ +++ L+QE
Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQG----EQKELSAQME------LLRQEV 1110
Query: 484 SENE-----RIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSL------Q 532
E E + +L E+LE H +L + + +LQ ++ + L Q
Sbjct: 1111 KEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQ 1170
Query: 533 EQGSKSEGESS-SKLKQKLEAHMEKLTEVHEELQ---KKQELIEDLQPDIN--------- 579
+ G++++ ++ + L L+ + + E EL + L+PD N
Sbjct: 1171 QPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRG 1230
Query: 580 --QNVQKINELEAALQKKDEDM-KAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRK 636
+ +AL K +D+ K + R + R+ ++ L+ +L AE +
Sbjct: 1231 PLLTALSAEAVASALHKLHQDLWKTQQTR-----DVLRDQVQKLEERLTDTEAEKSQVHT 1285
Query: 637 QLAEKERRIEILESE 651
+L + +R++ + E
Sbjct: 1286 ELQDLQRQLSQNQEE 1300
Score = 53.5 bits (127), Expect = 7e-07
Identities = 99/438 (22%), Positives = 193/438 (44%), Gaps = 59/438 (13%)
Query: 263 RLEAAKDDYRVHCEELEKQL------IEFQHRNDELTSLAEETRALKDEIDVLRATSDKA 316
+L+A YR C+ELEK+L I + N E +L E L++E + +
Sbjct: 58 KLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEE----QQRCESL 113
Query: 317 NKLESTVEIYRQKLQDLND-LRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYK 375
++ + + ++ +K +N LR+ V+ L + + + +E ++K + + + E +K
Sbjct: 114 AEVNTQLRLHMEKADVVNKALREDVEKLT------VDWSRARDELMRKESQWQMEQEFFK 167
Query: 376 RQVQDLHVKLSSESKRADTLA---FEMKRLEEKHEALLK-EKERLIEQRDTL-------- 423
++ H +L S + T EMK ++ LK E RL T
Sbjct: 168 GYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGA 227
Query: 424 --KETNEELRCSQVQQDH----LNQTDASATKSYENLAAEIM-----PVEYREVFIRLQH 472
+E N R + L +T +++E I +E E+ R+
Sbjct: 228 QSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTE 287
Query: 473 ENKMLRLQQEGSEN-----ERIEELQEQLEQKHRKMNELETE-QRLSKERIRELQQQIED 526
+ +L Q+ +E+ + + E E LE H ++ E E R ++E LQQ I+D
Sbjct: 288 LSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKD 347
Query: 527 LQKSLQEQGSK----SEGESSSKLKQKLEAHME------KLTEVHEELQKKQELIEDLQP 576
+ + + E+G S E+S +L + + + LT V L ++++ ++DL+
Sbjct: 348 ITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQ 407
Query: 577 DINQNVQKINELEAALQKKDEDMKAMEER-YKMYLEKARNVIKTLD--PKLNPASAEIML 633
+ + +N L+ + +E+ KA+ +R K+ E+ +T+D +++ S E L
Sbjct: 408 QLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKEREL 467
Query: 634 LRKQLAEKERRIEILESE 651
L+K E +++E+LE E
Sbjct: 468 LQKAREELRQQLEVLEQE 485
Score = 40.0 bits (92), Expect = 0.008
Identities = 36/149 (24%), Positives = 72/149 (48%), Gaps = 18/149 (12%)
Query: 512 LSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVH---------- 561
L+ + + LQ +E+ +LQ+Q ++++ S KLK EA + T V
Sbjct: 8 LNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYR 67
Query: 562 ---EELQKKQELIEDLQPDINQNVQK--INELEAALQKKDEDMKAMEE---RYKMYLEKA 613
+EL+K+ E P +NV++ ++EL L+++ + +++ E + ++++EKA
Sbjct: 68 SWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKA 127
Query: 614 RNVIKTLDPKLNPASAEIMLLRKQLAEKE 642
V K L + + + R +L KE
Sbjct: 128 DVVNKALREDVEKLTVDWSRARDELMRKE 156
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 100 bits (249), Expect = 5e-21
Identities = 130/572 (22%), Positives = 245/572 (42%), Gaps = 93/572 (16%)
Query: 175 ELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDG 234
E E+++ EE Q+ E + + +EL+ ++ TL EKN L + + +E L LD
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL--LDA 902
Query: 235 SFDDPNTVVAKKYFHAQL-----QLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQ--- 286
+ AK A++ + E +E N L A K C EL+K + + +
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962
Query: 287 ---------------HRNDELTSLAE-------ETRALKD----EIDVLRATSDKANKLE 320
+ +EL+ L E E +AL++ +D L+A DK N L
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLN 1022
Query: 321 STVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQD 380
T Q+++DL +Q K L+ + N LE +LK A + LE K+Q+ +
Sbjct: 1023 KTKSKLEQQVEDLESSLEQEKKLR---VDLERNKRKLEGDLKLAQESILDLENDKQQLDE 1079
Query: 381 L-------HVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCS 433
+ +L S+ + TL + ++ ++ +A ++E E IE + E+ R
Sbjct: 1080 RLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSD 1139
Query: 434 QVQQ-----DHLNQTDASATKSYE---NLAAEIMPVEYREVFIRLQHENKMLRLQQEGSE 485
++ + L + + E AE + + LQHE + L+++ ++
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199
Query: 486 NERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKS----------LQEQG 535
+ + EL EQ++ R +LE E+ K I +L +E + KS L++Q
Sbjct: 1200 S--VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQL 1257
Query: 536 SKSEGE------SSSKLKQKLEAHMEKLTEVHEELQKKQELI--------------EDLQ 575
S++ G+ S S+L + + E+ +L++K+ ++ E+L+
Sbjct: 1258 SEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELK 1317
Query: 576 PDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLR 635
+ + + N L ALQ D + E+Y E+ + L L+ A++E+ R
Sbjct: 1318 RQLEEENKAKNALAHALQSSRHDCDLLREQY----EEEQEGKAELQRALSKANSEVAQWR 1373
Query: 636 KQLAEK--ERRIEILESECKVA-KFRDYEEKL 664
+ +R E+ E++ K+A + +D EE++
Sbjct: 1374 TKYETDAIQRTEELEEAKKKLAQRLQDSEEQV 1405
Score = 94.0 bits (232), Expect = 4e-19
Identities = 123/565 (21%), Positives = 237/565 (41%), Gaps = 85/565 (15%)
Query: 129 INCEKKQEHIQNIMTLEES-VQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEEL 187
+N +++ E ++ LEE+ +QH M A L D+V EL +Q+
Sbjct: 1164 LNKKREAEFLKLRRDLEEATLQHEAMVAA--------LRKKHADSVAELGEQIDNLQRVK 1215
Query: 188 QEALAEKEELRQRCEELDMQVTTLQDEKNSL----------VSENEMMNEKLDQLDGSFD 237
Q+ EK E + ++L + ++ K +L +SE NE++ +
Sbjct: 1216 QKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELT 1275
Query: 238 DPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAE 297
+ + + QLE+ + +L +K + EEL++QL E N +LA
Sbjct: 1276 TQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE---ENKAKNALAH 1332
Query: 298 ETRALKDEIDVLRATSDKA-----------NKLESTVEIYRQKLQDLNDLRKQVKTLQET 346
++ + + D+LR ++ +K S V +R K + D ++ + L+E
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE--TDAIQRTEELEEA 1390
Query: 347 NMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKH 406
EE+++ NA LE K+++Q L + +RA++LA + + +
Sbjct: 1391 KKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNF 1450
Query: 407 EALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREV 466
+ +L E + E E+ EL S + L+ +YE ++ V+
Sbjct: 1451 DKVLAEWKTKCE------ESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK---- 1500
Query: 467 FIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIED 526
ENK L+QE I +L EQ+ + + ++ELE ++ +++ + D
Sbjct: 1501 -----RENK--NLEQE------IADLTEQIAENGKTIHELEKSRK-------QIELEKAD 1540
Query: 527 LQKSLQEQGSKSEGESSSKLKQKLEAHM------EKLTEVHEELQKK----QELIEDLQP 576
+Q +L+E + E E + L+ +LE K+ E EE+++ Q +E +Q
Sbjct: 1541 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQS 1600
Query: 577 DINQNVQKINELEAALQKKDEDMKAMEERYK----------MYLEKARNVIKTLDPKLNP 626
++ V+ NE +K + D+ +E + +L + +K L+
Sbjct: 1601 ALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDD 1660
Query: 627 ASAEIMLLRKQLAEKERRIEILESE 651
A L++QLA ERR +L++E
Sbjct: 1661 ALRGQEDLKEQLAIVERRANLLQAE 1685
Score = 87.4 bits (215), Expect = 4e-17
Identities = 120/573 (20%), Positives = 240/573 (41%), Gaps = 111/573 (19%)
Query: 136 EHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKE 195
E I + ++++Q A+ +L ++E + N +LEQQ+ E+L+ +L +++
Sbjct: 988 ETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQV----EDLESSLEQEK 1043
Query: 196 ELRQRCE----ELDMQVTTLQDEKNSLVSENEMMNEKLD-------QLDGSFDDPNTV-- 242
+LR E +L+ + Q+ L ++ + ++E+L QL +D T+
Sbjct: 1044 KLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGL 1103
Query: 243 -VAKKYFHAQLQLEQLQEE-------NFRLEAAKDDYRVHCEELEKQLIEF--------- 285
KK Q ++E+L+EE + E + DY EEL ++L E
Sbjct: 1104 QFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIE 1163
Query: 286 --QHRNDELTSL----------------------AEETRALKDEIDVLRATSDKANKLES 321
+ R E L A+ L ++ID L+ K K +S
Sbjct: 1164 LNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1223
Query: 322 TVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDL 381
++ +++DL ++++ ++ +LE++L +A R + E +R + +L
Sbjct: 1224 EFKL------EIDDLSSSMESVSKSKANLEKICRTLEDQLSEA---RGKNEEIQRSLSEL 1274
Query: 382 HVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLN 441
+++ R T A E+ R E+ E+++ + R + + EEL+ +++
Sbjct: 1275 ----TTQKSRLQTEAGELSRQLEEKESIVSQLSR---SKQAFTQQTEELKRQLEEENKAK 1327
Query: 442 QTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHR 501
A A +S +H+ +LR Q E E E ELQ L + +
Sbjct: 1328 NALAHALQSS-------------------RHDCDLLREQYE-EEQEGKAELQRALSKANS 1367
Query: 502 KMNELETEQRLSK-ERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEV 560
++ + T+ +R EL++ + L + LQ+ ++++EA K +
Sbjct: 1368 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDS------------EEQVEAVNAKCASL 1415
Query: 561 HEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTL 620
+ Q+ Q +EDL D V++ N L AAL KK + + +K E+++ ++
Sbjct: 1416 EKTKQRLQGEVEDLMVD----VERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAS 1471
Query: 621 DPKLNPASAEIMLLRKQLAEKERRIEILESECK 653
+ S E+ L+ E ++E ++ E K
Sbjct: 1472 LKESRSLSTELFKLKNAYEEALDQLETVKRENK 1504
Score = 68.2 bits (165), Expect = 3e-11
Identities = 115/537 (21%), Positives = 215/537 (40%), Gaps = 93/537 (17%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQ--QLKRALEELQE 189
E K++ Q + EE V+ V +K+ L D + ++E+ L AL++ Q
Sbjct: 1389 EAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQR 1448
Query: 190 ALAEK-EELRQRCEELDMQVTTLQDEKNSLVSE----NEMMNEKLDQLDG------SFDD 238
+ E + +CEE ++ E SL +E E LDQL+ + +
Sbjct: 1449 NFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ 1508
Query: 239 PNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEE 298
+ ++ + +L++ ++E K D ++ EE E L +H ++ + E
Sbjct: 1509 EIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL---EHEEAKILRIQLE 1565
Query: 299 TRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLND--------------LRKQVK-TL 343
+K EID R ++K ++E Y++ ++ + L+K+++ L
Sbjct: 1566 LTQVKSEID--RKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDL 1623
Query: 344 QETNMMYMHNTVSLEEELKKANAARTQLETYK-------RQVQDLHVKLSSESKRADTLA 396
E + H E LK + + QL+ + R +DL +L+ +RA+ L
Sbjct: 1624 NEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQ 1683
Query: 397 FEMKRLEEKHEA-----------LLKEKER---LIEQRDTLKETNEELRCSQVQ-QDHLN 441
E++ L E LL ER L Q +L T ++L +Q Q +
Sbjct: 1684 AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVE 1743
Query: 442 QTDASATKSYEN----------LAAEI------------MPVEYREVFIRLQHE-NKMLR 478
A + E +A E+ M + LQH ++ +
Sbjct: 1744 DASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1803
Query: 479 LQQEGSENE------RIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKS-- 530
L +G + + RI EL+ +LE + +K E R + R++EL Q E+ +K+
Sbjct: 1804 LALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1863
Query: 531 -LQEQGSKSEGESSSKLKQKLE------AHMEKLTEVHEELQKKQELIEDLQPDINQ 580
LQ+ K + + S +Q E AH+ K + EL++ +E + + +N+
Sbjct: 1864 RLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNK 1920
Score = 35.4 bits (80), Expect = 0.19
Identities = 26/114 (22%), Positives = 58/114 (50%), Gaps = 4/114 (3%)
Query: 543 SSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAM 602
S++ ++++ E+ + +EL K + ++L+ + VQ+ N+L+ +Q + E++
Sbjct: 843 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 603 EERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAK 656
EER L KA+ ++ ++ + + + +L K+R+ LE EC K
Sbjct: 903 EERCDQ-LIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRK---LEDECSELK 952
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 100 bits (249), Expect = 5e-21
Identities = 122/499 (24%), Positives = 222/499 (44%), Gaps = 60/499 (12%)
Query: 175 ELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDG 234
ELE+ K+ + LQ+A E + +C L+ LQ+E L+ + E N LD
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDK 1448
Query: 235 SFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTS 294
+ + ++A+ ++ +E + LEA++ + R EL K ++ D+L +
Sbjct: 1449 KQRNFDKILAE-------WKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLET 1501
Query: 295 LAEETRALKDEI-DVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHN 353
L E + L+ EI D+ ++ ++ +I +Q Q+ ++L+ ++ +
Sbjct: 1502 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAE--------- 1552
Query: 354 TVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEK 413
SLE E K + +L K +V K++ + + D + R+ E ++ L +
Sbjct: 1553 -ASLEHEEGKILRIQLELNQVKSEVDR---KIAEKDEEIDQMKRNHIRIVESMQSTLDAE 1608
Query: 414 ERLIEQRDTLKETNE-ELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQH 472
R LK+ E +L ++Q +H N+ A A ++Y N A + + H
Sbjct: 1609 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL--------H 1660
Query: 473 ENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETE-QRL-----SKERIRELQQQIED 526
+ LR Q E+L+EQL R+ N L+ E + L ER R++ +Q E
Sbjct: 1661 LDDALRSQ---------EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ-EL 1710
Query: 527 LQKSLQEQGSKSEGESSSKLKQKLEAHMEKLT-EVHEELQKKQELIEDLQPDINQNVQKI 585
L S + Q ++ S K+KLE + ++ E+ + +Q+ + E + I
Sbjct: 1711 LDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMA 1770
Query: 586 NELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLL---RKQLAEKE 642
EL KK++D A ER K LE+ +K L +L+ AE + L +KQ+ + E
Sbjct: 1771 EEL-----KKEQDTSAHLERMKKNLEQ---TVKDLQHRLD--EAEQLALKGGKKQIQKLE 1820
Query: 643 RRIEILESECKVAKFRDYE 661
R+ LE E + + R+ E
Sbjct: 1821 ARVRELEGEVESEQKRNVE 1839
Score = 93.6 bits (231), Expect = 6e-19
Identities = 107/501 (21%), Positives = 222/501 (44%), Gaps = 46/501 (9%)
Query: 176 LEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGS 235
L QL++ ++ELQ A EEL + E + +++ L E E ++E+L++ G+
Sbjct: 1104 LGMQLQKKIKELQ---ARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1160
Query: 236 FDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAK------------------DDYRVHCEE 277
+ K+ Q L+E + EA D+ + ++
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK 1220
Query: 278 LEKQLIEFQHRNDELTSLAEETRALKDEID-VLRATSDKANKLESTVEIYRQKLQDLNDL 336
LEK+ E + D+L S E K ++ + RA D+ +++++ E ++ + DL
Sbjct: 1221 LEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQ 1280
Query: 337 RKQVKTLQETNMMYMHNTVSLEEELKKANAART-QLETYKRQVQDLHVKLSSESKRADTL 395
R +++T + +L +L + A T Q+E KRQ+++ ++ ++S A L
Sbjct: 1281 RARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE---EIKAKSALAHAL 1337
Query: 396 AFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELR--CSQVQQDHLNQTDASATKSYEN 453
+ E +E+E E + + + N E+ ++ + D + +T+ ++ +
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE-ELEEAKKK 1396
Query: 454 LAAEIMPVEYREVFIRLQ---HENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQ 510
LA + E + + E RLQ E +E+L +E+ + L+ +Q
Sbjct: 1397 LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNE------VEDLMIDVERTNAACAALDKKQ 1450
Query: 511 RLSKERIRELQQQIEDLQKSLQEQGSKSEGESSS--KLKQKLEAHMEKLTEVHEELQKKQ 568
R + + E +Q+ E+ L+ +S S+ K+K E +++L + E + Q
Sbjct: 1451 RNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQ 1510
Query: 569 ELIEDLQPDINQNVQKINELE---AALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLN 625
+ I DL I + ++I+ELE ++++ +++A E + LE I + +LN
Sbjct: 1511 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELN 1570
Query: 626 PASAEIMLLRKQLAEKERRIE 646
+E+ +++AEK+ I+
Sbjct: 1571 QVKSEV---DRKIAEKDEEID 1588
Score = 89.4 bits (220), Expect = 1e-17
Identities = 113/525 (21%), Positives = 229/525 (43%), Gaps = 74/525 (14%)
Query: 175 ELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDG 234
E E+++ EE ++ E + + +EL+ ++ TL EKN L + + + L +
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 235 SFDDPNTVVAKKYFHAQL-----QLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQ--- 286
D + K A++ + E +E N L A K C EL+K + + +
Sbjct: 908 RCD--QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 287 -HRNDELTSLAEETRALKDEIDVLRATSDKANKLESTV-EIYRQKLQDLNDLRKQVKTLQ 344
E + + + L +E+ L T K K + + E ++Q L DL +V TL
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1025
Query: 345 ETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSES------------KRA 392
+ + LE L++ R LE KR+++ +KL+ ES ++
Sbjct: 1026 KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG-DLKLAQESTMDIENDKQQLDEKL 1084
Query: 393 DTLAFEMKRLEEK---HEAL-LKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASAT 448
FEM L+ K +AL ++ ++++ E + ++E EE+ + + + + +
Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144
Query: 449 KSYENL-----------AAEIMPVEYREVFIR----------LQHENKMLRLQQEGSENE 487
+ E + +A+I + RE + LQHE L+++ +++
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS- 1203
Query: 488 RIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLK 547
+ EL EQ++ R +Q+L KE+ E++ +I+DL ++ E SK++G L+
Sbjct: 1204 -VAELGEQIDNLQR------VKQKLEKEK-SEMKMEIDDLASNM-ETVSKAKG----NLE 1250
Query: 548 QKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYK 607
+ A ++L+E+ + +++Q LI DL + + E L +KD + + +
Sbjct: 1251 KMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQ 1310
Query: 608 MYLEKARNVIKTLDPKLNPASA----------EIMLLRKQLAEKE 642
+ ++ + + L+ ++ SA + LLR+Q E++
Sbjct: 1311 AFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQ 1355
Score = 84.3 bits (207), Expect = 4e-16
Identities = 116/548 (21%), Positives = 229/548 (41%), Gaps = 87/548 (15%)
Query: 177 EQQLKRALEE---LQEALA----EKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKL 229
E ++K EE L E +A EK+ L++ ++ + +D+ N+L + +++
Sbjct: 976 ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQV 1035
Query: 230 DQLDGSFDDPNTVV-----AKKYFHAQLQL----------------EQLQEENFR---LE 265
D L+GS + + AK+ L+L E+L+++ F L+
Sbjct: 1036 DDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQ 1095
Query: 266 AAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRAL-----KDEIDVLRATSDKANKLE 320
+ +D + +L+K++ E Q R +EL E RA K D+ R + + +LE
Sbjct: 1096 SKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE 1155
Query: 321 -----STVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAAR-TQLETY 374
++ +I K ++ + +K + L+E + + +L ++ + A Q++
Sbjct: 1156 EAGGATSAQIEMNKKREA-EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1214
Query: 375 KRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQ 434
+R Q L + S D LA M+ + + L K L +Q +K EE
Sbjct: 1215 QRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEE----- 1269
Query: 435 VQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSE--NERIEEL 492
QQ +N A + + E E +L ++ ++ G + ++IEEL
Sbjct: 1270 -QQRLINDLTAQRAR---------LQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEEL 1319
Query: 493 QEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKS---LQEQGSKSEGE-------- 541
+ QLE++ + + L + S+ L++Q E+ Q++ LQ SK+ E
Sbjct: 1320 KRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKY 1379
Query: 542 -------------SSSKLKQKL---EAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKI 585
+ KL Q+L E H+E + L+K ++ +++ D+ +V++
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERT 1439
Query: 586 NELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRI 645
N AAL KK + + +K E+ ++ + S E+ ++ E ++
Sbjct: 1440 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQL 1499
Query: 646 EILESECK 653
E L+ E K
Sbjct: 1500 ETLKRENK 1507
Score = 68.9 bits (167), Expect = 2e-11
Identities = 120/549 (21%), Positives = 227/549 (41%), Gaps = 93/549 (16%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQ------LKRALE 185
E K++ Q + EE V+ V +K+ L + D + ++E+ L +
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQR 1451
Query: 186 ELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSE----NEMMNEKLDQLDG------- 234
+ LAE +Q+CEE ++ Q E SL +E E LDQL+
Sbjct: 1452 NFDKILAE---WKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKN 1508
Query: 235 ---SFDDPNTVVA---KKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHR 288
D +A K+ + +Q+++E L+AA ++ E E +++ Q
Sbjct: 1509 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLE 1568
Query: 289 NDELTSLAEETRALKDE-IDVLRATSDK-ANKLESTVEIYRQKLQDLNDLRKQVK-TLQE 345
+++ S + A KDE ID ++ + ++ST++ + D L+K+++ L E
Sbjct: 1569 LNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1628
Query: 346 TNMMYMHNTVSLEEELKKANAARTQ---------LETYKRQVQDLHVKLSSESKRADTLA 396
+ H E L+ N TQ L+ R +DL +L+ +RA+ L
Sbjct: 1629 MEIQLNHANRMAAEALR--NYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQ 1686
Query: 397 FEMKRLEEKHEA-----------LLKEKER---LIEQRDTLKETNEELRC--SQVQ---Q 437
E++ L E LL ER L Q +L T ++L SQ+Q +
Sbjct: 1687 AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746
Query: 438 DHLNQ------------TDASAT----KSYENLAAEI--MPVEYREVFIRLQHE-NKMLR 478
D + + TDA+ K ++ +A + M + LQH ++ +
Sbjct: 1747 DIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1806
Query: 479 LQQEGSENE------RIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKS-- 530
L +G + + R+ EL+ ++E + ++ E R + +++EL Q E+ +K+
Sbjct: 1807 LALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNIL 1866
Query: 531 -LQEQGSKSEGESSSKLKQKLEA------HMEKLTEVHEELQKKQELIEDLQPDINQNVQ 583
LQ+ K + + S +Q EA ++ K + EL++ +E + + +N+
Sbjct: 1867 RLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRV 1926
Query: 584 KINELEAAL 592
K E+ +
Sbjct: 1927 KSREVHTKI 1935
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/250 (20%), Positives = 109/250 (43%), Gaps = 19/250 (7%)
Query: 139 QNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELR 198
Q ++ E VQ + + +K+ L + + GE+E ++ A ++A +
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAA 1767
Query: 199 QRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQ 258
EEL + QD L + + + + L D+ + K + Q+++L+
Sbjct: 1768 MMAEELKKE----QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKG---GKKQIQKLE 1820
Query: 259 EENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANK 318
LE + + E K L + + + ELT EE R ++LR D +K
Sbjct: 1821 ARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRK-----NILRL-QDLVDK 1874
Query: 319 LESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQV 378
L++ V+ Y+++ ++ + + V + + + LEE ++A+ A +Q+ + +
Sbjct: 1875 LQAKVKSYKRQAEEAEE-QSNVNLSKFRRIQH-----ELEEAEERADIAESQVNKLRVKS 1928
Query: 379 QDLHVKLSSE 388
+++H K+ SE
Sbjct: 1929 REVHTKIISE 1938
Score = 30.4 bits (67), Expect = 6.1
Identities = 24/114 (21%), Positives = 56/114 (49%), Gaps = 4/114 (3%)
Query: 543 SSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAM 602
S++ ++++ E+ + EEL K + ++L+ + +Q+ N+L+ +Q + + +
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADA 905
Query: 603 EERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAK 656
EER L K + ++ ++ + + + +L K+R+ LE EC K
Sbjct: 906 EERCDQ-LIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK---LEDECSELK 955
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 99.0 bits (245), Expect = 1e-20
Identities = 153/652 (23%), Positives = 277/652 (42%), Gaps = 88/652 (13%)
Query: 47 LHQIDAAWFNESWLSRIKEDVGDNWRIKASNVKKVLQGIMSYYHEF------LGQQISE- 99
+ QI A N + R ED + R KA ++ + + S + L +Q+ E
Sbjct: 1235 MEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEK 1294
Query: 100 -ALIPDLNQ--ITECSDPVELGRLLQ-----------LILGCAINCEKKQEHIQNIMTLE 145
ALI L + +T +L R L+ + +C+ +E + +
Sbjct: 1295 EALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAK 1354
Query: 146 ESVQHVVMTAIQELMSKEILSSPPNDAVG---ELEQQLKRALEELQEALAEKEELRQRCE 202
+Q V+ A E+ + DA+ ELE+ K+ + LQEA E + +C
Sbjct: 1355 AELQRVLSKANSEVAQWR--TKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 203 ELDMQVTTLQDEKNSLVSENEMMNEK---LDQLDGSFDDPNTVVAKKYFHAQLQLEQLQE 259
L+ LQ+E L+ + E N LD+ +FD +KY +Q +LE Q+
Sbjct: 1413 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472
Query: 260 ENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKL 319
E L EL K ++ + L + E + L++EI SD +L
Sbjct: 1473 EARSLST----------ELFKLKNAYEESLEHLETFKRENKNLQEEI------SDLTEQL 1516
Query: 320 ESTVEIYRQKLQDLNDLRKQVKTLQ-ETNMMYMHNTVSLEEELKKANAARTQLETYKRQV 378
S+ + + +L +RKQ++ + E SLE E K A+ + K ++
Sbjct: 1517 GSS----GKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI 1572
Query: 379 QDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNE-ELRCSQVQQ 437
+ KL+ + + + R+ + + L + R + +K+ E +L ++Q
Sbjct: 1573 ER---KLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQL 1629
Query: 438 DHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEE-----L 492
H N+ A A K ++L + + ++ I+L + +R + EN I E L
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLL-----KDTQIQL---DDAVRANDDLKENIAIVERRNNLL 1681
Query: 493 QEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEA 552
Q +LE+ + + E ++L+++ + E ++++ L S+ S K+K++A
Sbjct: 1682 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLH---------SQNTSLINQKKKMDA 1732
Query: 553 HMEKL-TEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLE 611
+ +L TEV E +Q+ + E + I EL KK++D A ER K +E
Sbjct: 1733 DLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL-----KKEQDTSAHLERMKKNME 1787
Query: 612 KARNVIKTLDPKLNPASAEIMLL--RKQLAEKERRIEILESECKVAKFRDYE 661
+ IK L +L+ A +I L +KQL + E R+ LE+E + + R+ E
Sbjct: 1788 QT---IKDLQHRLDEAE-QIALKGGKKQLQKLEARVRELENELEAEQKRNAE 1835
Score = 93.6 bits (231), Expect = 6e-19
Identities = 121/497 (24%), Positives = 212/497 (42%), Gaps = 60/497 (12%)
Query: 175 ELEQQLKRALEELQEALA-EKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLD 233
E E+ + +E+L+ L+ E EE+ +R EE T++Q E N E E + D +
Sbjct: 1123 EAERTARAKVEKLRSDLSRELEEISERLEEAG-GATSVQIEMNKK-REAEFQKMRRDLEE 1180
Query: 234 GSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELT 293
+ T A + HA + +L E+ L+ K ++LEK+ EF+ D++T
Sbjct: 1181 ATLQHEATAAALRKKHAD-SVAELGEQIDNLQRVK-------QKLEKEKSEFKLELDDVT 1232
Query: 294 SLAEETRALKDEIDVL-RATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMH 352
S E+ K ++ + R D+ N+ S E ++ + DL R +++T
Sbjct: 1233 SNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT---------- 1282
Query: 353 NTVSLEEELKKANAARTQLE----TYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEA 408
L +L + A +QL TY +Q++DL +L E K + LA ++ +
Sbjct: 1283 ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL 1342
Query: 409 LLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDA-----SATKSYENLAAEIMPVEY 463
L ++ E E + L+ + Q +TDA ++ + LA + E
Sbjct: 1343 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE- 1401
Query: 464 REVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQ 523
E + + L + +NE IE+L +E+ + L+ +QR + + E +Q+
Sbjct: 1402 -EAVEAVNAKCSSLEKTKHRLQNE-IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQK 1459
Query: 524 IEDLQKSLQEQGSKSEGESSS-----------KLKQKLEAHMEKLTEVHEELQKKQELIE 572
E+ S+SE ESS KLK E +E L E + QE I
Sbjct: 1460 YEE---------SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1510
Query: 573 DLQPDINQNVQKINELEAA---LQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASA 629
DL + + + I+ELE L+ + ++++ E + LE I + N A
Sbjct: 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570
Query: 630 EIMLLRKQLAEKERRIE 646
EI ++LAEK+ +E
Sbjct: 1571 EI---ERKLAEKDEEME 1584
Score = 92.4 bits (228), Expect = 1e-18
Identities = 115/490 (23%), Positives = 222/490 (45%), Gaps = 61/490 (12%)
Query: 180 LKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDP 239
+K L+EAL EK E R++ EL+ ++ +L EKN L QL +
Sbjct: 852 MKEEFTRLKEAL-EKSEARRK--ELEEKMVSLLQEKNDL------------QLQVQAEQD 896
Query: 240 NTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTS----L 295
N A++ + +QL + +LEA +E+ ++L + + N ELT+ L
Sbjct: 897 NLADAEE------RCDQLIKNKIQLEA-------KVKEMNERLEDEEEMNAELTAKKRKL 943
Query: 296 AEETRALKDEIDVLRATSDKANK----LESTVEIYRQKLQDLND----LRKQVKTLQETN 347
+E LK +ID L T K K E+ V+ +++ L++ L K+ K LQE +
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 348 MMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHE 407
+ + + E+++ A+ +LE +QV DL L E K + +++R + K E
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLE---QQVDDLEGSLEQEKK----VRMDLERAKRKLE 1056
Query: 408 ALLK-EKERLIEQRDTLKETNEELRCSQVQQDHLNQ--TDASATKSYENLAAEIMPVEYR 464
LK +E +++ + ++ +E L+ + + LN D A S + +
Sbjct: 1057 GDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIE 1116
Query: 465 EVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQI 524
E+ L+ E + R + E ++ EL+E E+ + ++K+R E Q+
Sbjct: 1117 ELEEELEAE-RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMR 1175
Query: 525 EDLQK-SLQEQGS-----KSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDI 578
DL++ +LQ + + K +S ++L +++ + L V ++L+K++ + D+
Sbjct: 1176 RDLEEATLQHEATAAALRKKHADSVAELGEQI----DNLQRVKQKLEKEKSEFKLELDDV 1231
Query: 579 NQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQL 638
N+++I + +A L+K ++ ++ E+ + + L + E L +QL
Sbjct: 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL 1291
Query: 639 AEKERRIEIL 648
EKE I L
Sbjct: 1292 DEKEALISQL 1301
Score = 85.5 bits (210), Expect = 2e-16
Identities = 122/549 (22%), Positives = 238/549 (43%), Gaps = 63/549 (11%)
Query: 136 EHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQ---LKRALEELQEALA 192
E I + ++++Q A+ +L ++E + A +LEQQ L+ +LE+ ++
Sbjct: 987 EIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRM 1046
Query: 193 EKEELRQRCE-ELDMQVTTLQDEKNSLVSENEMMNEK---LDQLDGSFDDPNTV---VAK 245
+ E +++ E +L + ++ D +N +E + +K L+ L+ +D + + K
Sbjct: 1047 DLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQK 1106
Query: 246 KYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDEL---TSLAEETRAL 302
K Q ++E+L+EE A+ +L ++L E R +E TS+ E
Sbjct: 1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKK 1166
Query: 303 KD-EIDVLRATSDKAN-KLESTVEIYRQKLQD-LNDLRKQVKTLQETNM----------M 349
++ E +R ++A + E+T R+K D + +L +Q+ LQ +
Sbjct: 1167 REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL 1226
Query: 350 YMHNTVSLEEELKKANAARTQL-ETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEA 408
+ + S E++ KA A ++ T + Q+ + K + + L + +L+ ++
Sbjct: 1227 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGE 1286
Query: 409 L---LKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYRE 465
L L EKE LI Q T +L +Q +D Q + K+ LA +
Sbjct: 1287 LSRQLDEKEALISQL-----TRGKLTYTQQLEDLKRQLEEEV-KAKNALAHALQSA---- 1336
Query: 466 VFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSK-ERIRELQQQI 524
+H+ +LR Q E E E ELQ L + + ++ + T+ +R EL++
Sbjct: 1337 -----RHDCDLLREQYE-EETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390
Query: 525 EDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQK 584
+ L + LQE ++ +EA K + + + + Q IEDL D V++
Sbjct: 1391 KKLAQRLQEA------------EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD----VER 1434
Query: 585 INELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERR 644
N AAL KK + + +K E++++ +++ + S E+ L+ E
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 645 IEILESECK 653
+E + E K
Sbjct: 1495 LETFKRENK 1503
Score = 84.7 bits (208), Expect = 3e-16
Identities = 134/574 (23%), Positives = 239/574 (41%), Gaps = 89/574 (15%)
Query: 179 QLKRALEELQEALAEKEE----LRQRCEELDMQVTTLQDE------------KNSLVSEN 222
+LK ALE+ + E EE L Q +L +QV QD KN + E
Sbjct: 858 RLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEA 917
Query: 223 EM--MNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQE--ENFRLEAAKDDYRVHCEEL 278
++ MNE+L+ ++ N + K + + +L+ ++ L AK + H E
Sbjct: 918 KVKEMNERLE----DEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATEN 973
Query: 279 E-KQLIEFQHRNDE-LTSLAEETRALKD----EIDVLRATSDKANKLESTVEIYRQKLQD 332
+ K L E DE + L +E +AL++ +D L+A DK N L Q++ D
Sbjct: 974 KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDD 1033
Query: 333 L------------------NDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETY 374
L L +K QE+ M ++ L+E LKK + +L
Sbjct: 1034 LEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKD---FELNAL 1090
Query: 375 KRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELR--- 431
+++D S K+ L ++ LEE+ EA + ++ + R L EE+
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Query: 432 -----CSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSEN 486
+ VQ + + +A K +L + E +R +H + + L G +
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL---GEQI 1207
Query: 487 ERIEELQEQLEQKHRKMNELETEQRLSK-ERIRELQQQIEDLQKSLQEQGS--KSEGESS 543
+ ++ ++++LE K + +LE + S E+I + + +E + ++L++Q + +S+ E +
Sbjct: 1208 DNLQRVKQKLE-KEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET 1266
Query: 544 SKLKQKLEAHMEKLT----EVHEELQKKQELI--------------EDLQPDINQNVQKI 585
+ L + KL E+ +L +K+ LI EDL+ + + V+
Sbjct: 1267 QRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAK 1326
Query: 586 NELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLR-KQLAEKERR 644
N L ALQ D + E+Y E+ L L+ A++E+ R K + +R
Sbjct: 1327 NALAHALQSARHDCDLLREQY----EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1382
Query: 645 IEILESECKVAKFRDYEEKLIVSAWYNKSLAFQK 678
E LE K R E + V A K + +K
Sbjct: 1383 TEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEK 1416
Score = 80.9 bits (198), Expect = 4e-15
Identities = 103/436 (23%), Positives = 204/436 (46%), Gaps = 65/436 (14%)
Query: 253 QLEQLQEENFRLEAAKDDYRVHCEELEKQLIE-FQHRNDELTSLAEETRALKDEIDVLRA 311
++ ++EE RL+ A + +ELE++++ Q +ND + E L D +
Sbjct: 848 EMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQ 907
Query: 312 TSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQL 371
+LE+ V+ ++L+D ++ ++ + LE+E +
Sbjct: 908 LIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKR----------KLEDECSE-------- 949
Query: 372 ETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEE-L 430
KR + DL + L+ K ++K L E+ L + +L +++ L+E +++ L
Sbjct: 950 --LKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL 1007
Query: 431 RCSQVQQDHLNQTDASATKSYENLAAEIMPVE---YREVFIRLQHENKM------LRLQQ 481
Q ++D +N + TK+ L ++ +E +E +R+ E L+L Q
Sbjct: 1008 DDLQAEEDKVN----TLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063
Query: 482 EG---SENERIEELQEQLEQKHRKMNEL----ETEQRLS---KERIRELQQQIEDLQKSL 531
E EN++ ++L E+L++K ++N L E EQ L +++++ELQ +IE+L++ L
Sbjct: 1064 ESIMDLENDK-QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL 1122
Query: 532 Q-EQGSKSEGES-SSKLKQKLEAHMEKL------TEVHEELQKKQEL-IEDLQPDINQNV 582
+ E+ ++++ E S L ++LE E+L T V E+ KK+E + ++ D+ +
Sbjct: 1123 EAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEAT 1182
Query: 583 QKINELEAALQKKDEDMKA-------MEERYKMYLEKARNVIKTLDPKLNPASAEIMLLR 635
+ AAL+KK D A +R K LEK ++ K +L+ ++ + +
Sbjct: 1183 LQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL---ELDDVTSNMEQII 1239
Query: 636 KQLAEKERRIEILESE 651
K A E+ LE +
Sbjct: 1240 KAKANLEKMCRTLEDQ 1255
Score = 70.5 bits (171), Expect = 5e-12
Identities = 93/474 (19%), Positives = 196/474 (41%), Gaps = 61/474 (12%)
Query: 175 ELEQQLKRALEELQEALAEKEELRQRCEELDMQVTT-------LQDEKNSLVSENEMMNE 227
+L+ + +LE L+ E + L++ +L Q+ + L+ + L +E +
Sbjct: 1483 KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQS 1542
Query: 228 KLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQH 287
L++ + S + K AQL+ Q++ E R A KD EE+E+
Sbjct: 1543 ALEEAEASLEHEEG----KILRAQLEFNQIKAEIERKLAEKD------EEMEQAKRNHLR 1592
Query: 288 RNDEL-TSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQET 346
D L TSL ETR+ + + V + N++E + + + K +++L +
Sbjct: 1593 VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1652
Query: 347 NMMYMHNTVSLEEELK--------KANAARTQLETYKRQVQDLHVKLSSESKRADTLAFE 398
+ + + V ++LK + N + +LE + V+ + +
Sbjct: 1653 TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER 1712
Query: 399 MKRLEEKHEALLKEKERLIEQRDTLKETNEEL--RCSQVQQDHLNQ-TDASAT----KSY 451
++ L ++ +L+ +K+++ L+ EE C ++ TDA+ K
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE 1772
Query: 452 ENLAAEI--MPVEYREVFIRLQHE-NKMLRLQQEGSENE------RIEELQEQLEQKHRK 502
++ +A + M + LQH ++ ++ +G + + R+ EL+ +LE + ++
Sbjct: 1773 QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKR 1832
Query: 503 MNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHE 562
E R S+ RI+EL Q E+ +K+L + KL+ K++A+ + E E
Sbjct: 1833 NAESVKGMRKSERRIKELTYQTEEDRKNLLRL-----QDLVDKLQLKVKAYKRQAEEAEE 1887
Query: 563 ELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNV 616
+ N N+ K +++ L + +E E + K+R++
Sbjct: 1888 Q--------------ANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1927
Score = 62.8 bits (151), Expect = 1e-09
Identities = 99/459 (21%), Positives = 191/459 (41%), Gaps = 62/459 (13%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMS------------------KEILSSPPNDAV 173
E+ EH++ +++Q + ++L S K L S +A
Sbjct: 1489 EESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAE 1548
Query: 174 GELEQQ----LKRALE------ELQEALAEKEELRQRCEELDMQV-----TTLQDE---K 215
LE + L+ LE E++ LAEK+E ++ + ++V T+L E +
Sbjct: 1549 ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSR 1608
Query: 216 NSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHC 275
N + + M L++++ N + A+ AQ Q++ LQ + DD
Sbjct: 1609 NEALRVKKKMEGDLNEMEIQLSHANRMAAE----AQKQVKSLQSLLKDTQIQLDDAVRAN 1664
Query: 276 EELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRA--------TSDKANKLES-TVEIY 326
++L++ + + RN+ L + EE RA+ ++ + R TS++ L S +
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724
Query: 327 RQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLS 386
QK + DL Q++T E + N EE+ KKA + ++ QD L
Sbjct: 1725 NQKKKMDADL-SQLQTEVEEAVQECRNA---EEKAKKAITDAAMMAEELKKEQDTSAHLE 1780
Query: 387 SESKRADTLAFEMK-RLEEKHEALLKEKERLIEQRDT-LKETNEELRCSQVQQDHLNQTD 444
K + +++ RL+E + LK ++ +++ + ++E EL Q + N
Sbjct: 1781 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKR----NAES 1836
Query: 445 ASATKSYENLAAEI--MPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRK 502
+ E E+ E R+ +RLQ L+L+ + + + EE +EQ K
Sbjct: 1837 VKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQA-EEAEEQANTNLSK 1895
Query: 503 MNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGE 541
+++ E ++ER + Q+ L+ ++ G+K E
Sbjct: 1896 FRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLNE 1934
Score = 45.8 bits (107), Expect = 1e-04
Identities = 47/227 (20%), Positives = 107/227 (47%), Gaps = 21/227 (9%)
Query: 388 ESKRADTLAFEMKRLEEKHEALLKEKE--RLIEQRDTLKETNEELRCSQVQQDHLNQTDA 445
E R + L+ + R++ + +L E +L+E+RD+L +R + +
Sbjct: 774 EEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRA------FMGVKNW 827
Query: 446 SATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNE 505
K Y + + E + ++ E L+ E SE R +EL+E++ ++ N+
Sbjct: 828 PWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARR-KELEEKMVSLLQEKND 886
Query: 506 LETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQ 565
L+ + + ++ + + +++ + L K++ + +K+K+ E +E E++ EL
Sbjct: 887 LQLQVQAEQDNLADAEERCDQL--------IKNKIQLEAKVKEMNE-RLEDEEEMNAELT 937
Query: 566 KKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEK 612
K+ +ED ++ ++ I++LE L K +++ A E + K E+
Sbjct: 938 AKKRKLEDECSELKRD---IDDLELTLAKVEKEKHATENKVKNLTEE 981
Score = 35.8 bits (81), Expect = 0.14
Identities = 27/120 (22%), Positives = 63/120 (52%), Gaps = 5/120 (4%)
Query: 543 SSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAM 602
S++ ++++ + E+ T + E L+K + ++L+ + +Q+ N+L+ +Q + +++
Sbjct: 842 SAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA 901
Query: 603 EERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEE 662
EER L K + ++ ++N + + +L K+R+ LE EC K RD ++
Sbjct: 902 EERCDQ-LIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRK---LEDECSELK-RDIDD 956
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 99.0 bits (245), Expect = 1e-20
Identities = 126/612 (20%), Positives = 265/612 (43%), Gaps = 60/612 (9%)
Query: 93 LGQQISEALIPDLNQITECSDPVELGRLLQLILGCAINCEKKQEHIQNIMTLEESVQ--H 150
+ ++ A+ L I+E S +E ++ Q L + +KQE +++ EE + H
Sbjct: 1846 ISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL-MRESFRQKQEATESLKCQEELRERLH 1904
Query: 151 VVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEE----LRQRCEELDM 206
A ++L + + D + + +R ++E + + E+ R +EL+
Sbjct: 1905 EESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA 1964
Query: 207 QVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEA 266
+ +Q+E+ L + E M + ++ + K+ Q Q E+++++ L+
Sbjct: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDD---LQK 2021
Query: 267 AKDDYRVHCEELEKQLIEF-QHRNDELTSLAEETRALKDEIDVLRATSDK-ANKLESTVE 324
+ EE + IE Q +N EL L ++ +AL+ +++ +R D+ A E +
Sbjct: 2022 QVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERD 2081
Query: 325 IYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVK 384
+++Q++Q L K V Q + L LK+ ++L K Q+Q
Sbjct: 2082 VFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR---D 2138
Query: 385 LSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTD 444
+ ++ + L F ++ LE+ ALL E + + E + E++ Q ++D +++ +
Sbjct: 2139 IQERNEEIEKLEFRVRELEQ---ALLVEDRKHFGAVEAKPELSLEVQL-QAERDAIDRKE 2194
Query: 445 ASATKSYENLAA-------EIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLE 497
T E L + V+ + + +Q + RLQ+ EN+ ++ E+L
Sbjct: 2195 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLG 2254
Query: 498 QKHRKMNELETEQR-----------LSKE-RIRELQQQIEDLQKSLQEQGSKSEGESSSK 545
++ + + T+ + KE I +L +Q+ LQ+ L+ E ++
Sbjct: 2255 LAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNE 2314
Query: 546 LKQKLEAHMEKLTEVHE--------ELQKKQELIEDLQPDINQNVQKINELEAALQKKDE 597
L + LE +E L E E+++ E+IE LQ ++ QK + +L ++ +
Sbjct: 2315 LIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEAD 2374
Query: 598 DMK-----------AMEERYKMYLEKA---RNVIKTLDPKLNPASAEIMLLRKQLAEKER 643
+K A+E++ + E+ +NV+K + K+N + E+ L+++ E+
Sbjct: 2375 SLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEK 2434
Query: 644 RIEILESECKVA 655
I E+ VA
Sbjct: 2435 IQSIPENSVNVA 2446
Score = 98.6 bits (244), Expect = 2e-20
Identities = 127/594 (21%), Positives = 259/594 (43%), Gaps = 72/594 (12%)
Query: 118 GRLLQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVG--- 174
G + QL +K E ++ + L E Q + + Q+L + E L + + +
Sbjct: 205 GIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ-FQQLQASETLRNSTHSSTAADL 263
Query: 175 -ELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMM-----NEK 228
+ +QQ+ ++L+E E+ +++ E+ MQ++ LQ++ E + E+
Sbjct: 264 LQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE 323
Query: 229 LDQLDGSFDDPNTVVAK----------KYFHAQLQLEQLQEE---------NFRLEA--A 267
+ + + ++ NT + + K A L +LQE+ N +LE +
Sbjct: 324 IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383
Query: 268 KDDYRVHCEELEKQLI----EFQHRN--------DELTSLAEETRALKDEIDVLRATSDK 315
K R EE+ KQL+ E Q RN D + + +ET+ +++ LRA D+
Sbjct: 384 KQKERQSSEEI-KQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR---KLEQLRAELDE 439
Query: 316 A---NKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLE 372
++ E+ RQ + + +++ + K E + N E+++K N A
Sbjct: 440 MYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA----- 494
Query: 373 TYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRC 432
+ +L++KL + + + L E+ + E+ AL ++ E L+E+ +E + R
Sbjct: 495 -----INELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549
Query: 433 SQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKM--LRLQQEGSENERIE 490
+ +Q+ + + E+L AEI+ + L+HE ++ +++ E E E+
Sbjct: 550 TIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609
Query: 491 ELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKL 550
L E + ++ L T+ S E EL + EDL+ + K + KQ++
Sbjct: 610 VLDRMAESQEAELERLRTQLLFSHE--EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQI 667
Query: 551 EAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAAL-QKKDEDMKAMEERYKMY 609
+ ++++ E +Q +++ + Q + + K+ +L+ +L K E+M +
Sbjct: 668 DGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKE 727
Query: 610 LEKARNVIK---TLDPKLNPASAEIMLLRKQLAEKERRIE----ILESECKVAK 656
+E R K TL+ ++ + LL KQ+ EKE ++ LE+E + K
Sbjct: 728 IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781
Score = 75.9 bits (185), Expect = 1e-13
Identities = 122/573 (21%), Positives = 240/573 (41%), Gaps = 98/573 (17%)
Query: 172 AVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMN----- 226
A+ + + + + LQ+A EK+E + EL Q LQ + L + + N
Sbjct: 199 AIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSS 258
Query: 227 ----------------EKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDD 270
++L++ D +D K+ F Q+ Q + + + +E K
Sbjct: 259 TAADLLQAKQQILTHQQQLEEQDHLLEDYQK--KKEDFTMQISFLQEKIKVYEMEQDKKV 316
Query: 271 YRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDK------ANKLESTVE 324
+ EE++++ + N ++ ++T LKD++ T+DK ++ E
Sbjct: 317 ENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKL----TTADKLLGELQEQIVQKNQE 372
Query: 325 IYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVK 384
I KL+ N +K+ ++ +E + + EEL+K N +Q ET Q + +
Sbjct: 373 IKNMKLELTNSKQKERQSSEEIKQL-----MGTVEELQKRNHKDSQFETDIVQRMEQETQ 427
Query: 385 LSSESKRADTLAFEMKRLEEKH-EALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQT 443
E RA+ L+E + + +++ K+ LI Q E +++ H +
Sbjct: 428 RKLEQLRAE--------LDEMYGQQIVQMKQELIRQHMAQME--------EMKTRHKGEM 471
Query: 444 DASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERI-EELQEQLEQK--- 499
+ +A +SY N+ ++ V I ++LQ S+ E++ EEL LE+K
Sbjct: 472 E-NALRSYSNITVNEDQIKLMNVAI----NELNIKLQDTNSQKEKLKEELGLILEEKCAL 526
Query: 500 HRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSK------------SEGESSSKLK 547
R++ +L E S+E+I+ +Q I + + L E S ES +L+
Sbjct: 527 QRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELE 586
Query: 548 QKLEAHMEKLTEVHEELQKKQELIEDLQPDINQ------NVQKINELEAALQKKDEDMKA 601
K EA + E L+K++ + D + + Q + E L K ED
Sbjct: 587 LKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED--- 643
Query: 602 MEERYKMYLEKARNVI-----KTLDPKLNPASAEIMLL---RKQLAEKERRIEILESECK 653
+E +++ +EK ++ + + +D N S +I + + L K+ ++ ILE
Sbjct: 644 LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQL-ILE---- 698
Query: 654 VAKFRDYEEKLIVSAWYNKSLAFQKLGMESRLV 686
++K +D ++ L+ S +L +L E ++
Sbjct: 699 ISKLKDLQQSLVNSKSEEMTLQINELQKEIEIL 731
Score = 75.5 bits (184), Expect = 2e-13
Identities = 97/467 (20%), Positives = 208/467 (44%), Gaps = 64/467 (13%)
Query: 257 LQEENFRL-----EAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETR----------- 300
L+EE F + E D H E +E +L QH +EL EE R
Sbjct: 134 LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQL 193
Query: 301 -----ALKDE---IDVLRATSDKANK-LESTVEIYRQKLQDLNDLRKQVKTLQETNMMYM 351
A+K I L A +A + + T+ + + + L+ Q + LQ + +
Sbjct: 194 QEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRN 253
Query: 352 HNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLK 411
S +L + A+ Q+ T+++Q+++ L K+ + ++ L+EK +
Sbjct: 254 STHSSTAADLLQ---AKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEM 310
Query: 412 EKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQ 471
E+++ +E + + +E ++ + + + + A+ + E +E ++
Sbjct: 311 EQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370
Query: 472 HENKMLRL------QQEGSENERIEELQ---EQLEQKHRKMNELETE--QRLSKERIREL 520
E K ++L Q+E +E I++L E+L++++ K ++ ET+ QR+ +E R+L
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKL 430
Query: 521 QQQIEDLQKSLQEQGSKSEGESSSKLKQKL-EAHMEKLTEVHEELQKKQELIEDLQPDIN 579
+Q L+ + + G+ ++KQ+L HM ++ E+ + + K E+ L+ N
Sbjct: 431 EQ--------LRAELDEMYGQQIVQMKQELIRQHMAQMEEM--KTRHKGEMENALRSYSN 480
Query: 580 QNVQK---------INELEAALQKKDEDMKAMEERYKMYLEK---ARNVIKTLDPKLNPA 627
V + INEL LQ + + ++E + LE+ + ++ L +L+ +
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
Query: 628 SAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEKLIVSAWYNKSL 674
+I R+ +AE+E ++ E+ ++ D + +++ ++ K L
Sbjct: 541 REQIQRARQTIAEQESKLN--EAHKSLSTVEDLKAEIVSASESRKEL 585
Score = 74.7 bits (182), Expect = 3e-13
Identities = 105/509 (20%), Positives = 224/509 (44%), Gaps = 39/509 (7%)
Query: 145 EESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQE-ALAEKEELRQRCEE 203
+E +Q + ++L + + + + V E E+ L LE L++ +LA +E+L CE
Sbjct: 1623 QEQLQEEIKRLNRQLAQRSSIDN--ENLVSERERVLLEELEALKQLSLAGREKLC--CEL 1678
Query: 204 LDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDD-PNTVVAKKYFHAQLQLEQLQEENF 262
+ T +N E + EK +LD +D P +++ + + Q +L +
Sbjct: 1679 RNSSTQTQNGNENQGEVEEQTFKEK--ELDRKPEDVPPEILSNERYALQKANNRLLK--I 1734
Query: 263 RLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKL-ES 321
LE K V E + + ++ R+ + S A + E V ++ ++ +
Sbjct: 1735 LLEVVKTTAAVE-ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE 1793
Query: 322 TVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDL 381
++ Y ND+ K +E L + L ++ A T+++ + ++L
Sbjct: 1794 SIPSYSGSDMPRNDINMWSKVTEEGT--------ELSQRLVRSGFAGTEIDP---ENEEL 1842
Query: 382 HVKLSSESKRADTLAFEM--KRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDH 439
+ +SS + A E + + A + + E + E +E E L+C + ++
Sbjct: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRER 1902
Query: 440 LNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQK 499
L++ +++ E LA E+ E I + K L +Q + + I+ L+++L
Sbjct: 1903 LHEE----SRAREQLAVELSKAEG---VIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
Query: 500 HRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTE 559
++ ELE EQ+ +E L +Q E ++ + E+ +K+KLE + +
Sbjct: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA-EK 2014
Query: 560 VHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKT 619
V ++LQK+ ++ L+ D+ + V + ELE + D++ + + LEK R K
Sbjct: 2015 VRDDLQKQ---VKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR---KF 2068
Query: 620 LDPKLNPASAEIMLLRKQLAEKERRIEIL 648
LD + E + ++++ + E++++++
Sbjct: 2069 LDEQAIDREHERDVFQQEIQKLEQQLKVV 2097
Score = 73.9 bits (180), Expect = 5e-13
Identities = 106/519 (20%), Positives = 234/519 (45%), Gaps = 77/519 (14%)
Query: 163 EILSSPPNDAVGELEQQLKRALEELQEAL--AEKEELRQRCEELDMQ----VTTLQDE-- 214
E+L N + + + + LE L+ L + +EEL + E+L+++ + L+D
Sbjct: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
Query: 215 ---KNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQL-QLEQLQEENFRLEAAKDD 270
K + M++K++ + F+ N + + ++ +L+ LQ+ + + ++
Sbjct: 661 IHYKQQIDGLQNEMSQKIETMQ--FEKDNLITKQNQLILEISKLKDLQQS--LVNSKSEE 716
Query: 271 YRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVL-RATSDKANKLESTVEIYRQK 329
+ EL+K++ + E +L +E + L+ + ++L + +K N L+ E + Q
Sbjct: 717 MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ---EKFAQL 773
Query: 330 LQDLNDLRKQVKTLQETNMMYMHNTVSLEEEL---------KKANAARTQLETYKRQVQD 380
+ + L+ + KTL++ M+ +H VS EE L K + ++E + +D
Sbjct: 774 EAENSILKDEKKTLED--MLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 381 LH---VKLSSE-SKRADTLAFEMKR-------LEEKHEALLKEKERL--------IEQRD 421
L ++L+ E K+ +T +F K L+E++ LLK K+ L +E +
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKS 891
Query: 422 TLKETNEELRCSQVQQDHLNQT----DASATKSYENLA-AEIMPVEYREVFIRLQ-HENK 475
LK NEEL ++ + D T E L E++ + E+ +L+ + +
Sbjct: 892 KLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKRE 951
Query: 476 MLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQG 535
L L Q R+ +L EQL+QKH +++ L E + K+ ++ + +L+ +
Sbjct: 952 KLELSQ------RLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 536 SKSEGESSSKLKQKLEAHME--------KLTEVHEEL-QKKQELIEDLQPDINQNVQKIN 586
+++ +++ L+ + +++V++ ++ + ++ED N V + +
Sbjct: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
Query: 587 ELEAAL------QKKDEDMKAMEERYKMYLEKARNVIKT 619
+ E + K+ ++A + L+K NV+K+
Sbjct: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS 1104
Score = 73.9 bits (180), Expect = 5e-13
Identities = 115/591 (19%), Positives = 249/591 (42%), Gaps = 89/591 (15%)
Query: 144 LEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEE 203
L E +H + +S E+ DA+ E+++ E+L++ E E + ++
Sbjct: 2161 LVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ 2220
Query: 204 LDMQVTTLQDEKNS----LVSENEMMNEKLDQLDGSFDDPNTV-----------VAKKYF 248
L MQ+ + E + L EN++ + +++L + + + + A+
Sbjct: 2221 LHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ 2280
Query: 249 HAQLQLEQLQEENFRL-----------------EAAKD-DYRVHCEELEKQLIEFQHRND 290
+++++QL E+ +L E +D + ++ C +++ ++ ++R +
Sbjct: 2281 EKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK-RNREE 2339
Query: 291 ELTSLAEETRALKDEI-DVLRATSDKANKLESTVEIYRQKLQ----DLNDLRKQVKTLQE 345
E+ L E L+ E+ ++ + TS A+ L + + +L + L +QV+T E
Sbjct: 2340 EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE 2399
Query: 346 TNMMYMHNTV---------------SLEEELKKA--------NAARTQLETYKRQVQDLH 382
M +M N + SL+ E + N+ ++ + +L
Sbjct: 2400 -EMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELE 2458
Query: 383 VKLSSESKRADTLAFEMKRLEEKHE-ALLKEKERLIEQRDTLKETNEELRCSQVQQDHLN 441
V L+ ++ ++ K EE + +++ + RL++ T+ + EL Q +
Sbjct: 2459 VVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518
Query: 442 QTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKH- 500
+ T+ + + + +V L + ++ +Q+ + + + + E+ +
Sbjct: 2519 EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNI 2578
Query: 501 RKMNELETEQRLSKE------RIRELQQQIEDLQKSL---QEQGSKSEGESSSKLKQKLE 551
+ +N+L E L + RI EL+ Q+ ++ SL +EQ +E K K+ LE
Sbjct: 2579 QNLNQLR-EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE 2637
Query: 552 AHMEKLTEVHEELQKKQEL------IEDLQPDI-----NQNVQKINELEAALQKKDEDMK 600
++KL E +E+ Q+++E +E L+ N+ NELE AL+ + K
Sbjct: 2638 --LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELE-ALRAESVATK 2694
Query: 601 AMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESE 651
A YK EK + + + + ++ +R LAE + ++ ILE E
Sbjct: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE 2745
Score = 72.4 bits (176), Expect = 1e-12
Identities = 119/562 (21%), Positives = 239/562 (42%), Gaps = 83/562 (14%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRA-LEELQEA 190
E+++ +I I +L++ + + + E+ +D GEL L++ LEE
Sbjct: 2974 EERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVL 3033
Query: 191 LAEKEE----------------LRQRCEELDMQVTTLQD-----EKNSLVSENEMMNEKL 229
LA L QR +E ++ + ++ SL+SE + ++
Sbjct: 3034 LAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA-- 3091
Query: 230 DQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRN 289
Q++G + K+ ++ ++L E N + + + + LE Q +E
Sbjct: 3092 -QMNG-----RKITLKREQESEKPSQELLEYNIQQKQS--------QMLEMQ-VELSSMK 3136
Query: 290 DELTSLAEETRALKDEIDVLRATSDKAN-KLESTVEIYRQKLQDLNDLRKQVKTLQETNM 348
D T L E+ + K + L++ + +LE+T++ + L++L R +VK +T+
Sbjct: 3137 DRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK--DKTDE 3194
Query: 349 MYMHNTVSLEEELK-----------KANAARTQLETYKRQVQDLHVKLSSESKRADTLAF 397
+++ N E+ K KA R++ E K +++DL L S+ +R
Sbjct: 3195 VHLLNDTLASEQKKSRELQWALEKEKAKLGRSE-ERDKEELEDLKFSLESQKQRN----L 3249
Query: 398 EMKRLEEKHEALLKEKERLIEQRDTLKET--NEELRCSQVQQDHLNQTDASATKSYENLA 455
++ L E+ + LL E ++ IE + L + +EE + Q L + L
Sbjct: 3250 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309
Query: 456 AEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKE 515
E RE+ +LQ + + + + ++ELQ+QLE+KH ++ EL E K
Sbjct: 3310 RE------RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3363
Query: 516 RIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQ 575
+ +QQ+E + ++ L+ E TE +++ + Q +EDLQ
Sbjct: 3364 DSLQTRQQME---------------KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQ 3408
Query: 576 PDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLN-PASAEIMLL 634
+ + Q++ +L+ Q+ M+ +++ ++ E+ R + L LN P + +
Sbjct: 3409 RQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ-ELEREEKRESRRILYQNLNEPTTWSLTSD 3467
Query: 635 RKQLAEKERRIEILESECKVAK 656
R + +++IE E AK
Sbjct: 3468 RTRNWVLQQKIEGETKESNYAK 3489
Score = 67.4 bits (163), Expect = 4e-11
Identities = 112/506 (22%), Positives = 224/506 (44%), Gaps = 65/506 (12%)
Query: 193 EKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQL 252
E EL QR T + E L+ ++ +L + + + + HA++
Sbjct: 1817 EGTELSQRLVRSGFAGTEIDPENEELMLN---ISSRLQAAVEKLLEAISETSSQLEHAKV 1873
Query: 253 QLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELT-----------SLAEETRA 301
+L E+FR + + EEL ++L E ++L A+E
Sbjct: 1874 TQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTL 1933
Query: 302 LKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEEL 361
+ +I + +D ++LE + +LQ+L ++Q++ +E +S ++E
Sbjct: 1934 FERQI---QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL--------LSRQKEA 1982
Query: 362 KKANAARTQL----ETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLI 417
KA A + ET K + L V+ +E R D L ++K LE E ++ R I
Sbjct: 1983 MKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR-DDLQKQVKALEIDVE---EQVSRFI 2038
Query: 418 EQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFI----RLQHE 473
E +E N EL + Q L + K + A + R+VF +L+ +
Sbjct: 2039 ELE---QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID--REHERDVFQQEIQKLEQQ 2093
Query: 474 NKMLRLQQEGSENE--RIEELQEQLEQKHRKMNEL----ETEQRLSKER---IRELQQQI 524
K++ Q SE++ +E+L L++K K +EL E QR +ER I +L+ ++
Sbjct: 2094 LKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV 2153
Query: 525 EDLQKSLQEQGSKSEGESSSK----LKQKLEAHMEKLTEVHEELQKKQELIEDLQPDI-- 578
+L+++L + K G +K L+ +L+A + + +E+ +E +E + ++
Sbjct: 2154 RELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2213
Query: 579 -NQNVQKINELEAALQKKDED--MKAMEERYKMY---LEKARNVIKTLDPKLNPASAEIM 632
N+ VQ+++ ++ +QKK+ ++ +E+ K++ +EK IK D ++ ++
Sbjct: 2214 KNEEVQQLH-MQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVL 2271
Query: 633 LLRKQLAEKERRIEILESECKVAKFR 658
+ +E+ +EI + +V K +
Sbjct: 2272 FGKFAQIIQEKEVEIDQLNEQVTKLQ 2297
Score = 57.0 bits (136), Expect = 6e-08
Identities = 122/617 (19%), Positives = 248/617 (40%), Gaps = 125/617 (20%)
Query: 149 QHVVMTAIQELMS-KEILSSPPNDAVGELEQQLK-----RALEELQEALAE--------- 193
QHV+ +++ KE+ N+ V +L+QQLK + +EE E + +
Sbjct: 2268 QHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLM 2327
Query: 194 ------KEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKY 247
K + E+L+ + LQ E ++ + M L + S VV +
Sbjct: 2328 SDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEK 2387
Query: 248 FHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRND---ELTSLAEETRAL-- 302
+ Q+E EE ++ + +L ++L + + ++ S+ E + +
Sbjct: 2388 LALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAI 2447
Query: 303 ------KDEIDVLRATSDKANKLE--------------STVEIYRQKLQ----------D 332
K E++V+ T D LE S + + + LQ +
Sbjct: 2448 DHLSKDKPELEVV-LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLE 2506
Query: 333 LNDLRKQVKTLQETNM----MYMHNTVSL----EEELKKANAARTQLET---YKRQVQDL 381
L KQ+K +QE M V+L EE++ A ++ QLE Y + QD
Sbjct: 2507 LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQD- 2565
Query: 382 HVKLSSESKRAD-----------------TLAFEMKRLE----EKHEALLKEKERL-IEQ 419
+ +SSE +R + L + LE E H +L+ EKE++ I +
Sbjct: 2566 NQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAE 2625
Query: 420 RDTLKETNEELRCSQVQQ-DHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENK--- 475
++ L++ + L ++ + + Q + +S ++ VE + L H N+
Sbjct: 2626 KNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQD-------VEVLKTTTELFHSNEESG 2678
Query: 476 ------MLRLQ------QEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQ 523
LR + + S E+ E+LQE+L K M L+ + ++ + E +++
Sbjct: 2679 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2738
Query: 524 IEDLQKSLQEQGSKSEGES-----SSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDI 578
+ L+K + + +S+ KL + + + + ++ Q Q L+++ I
Sbjct: 2739 LSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQI 2798
Query: 579 NQ----NVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLL 634
N + +++ E+ + +K E M+ + + +E +R++ +T K A + LL
Sbjct: 2799 NLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDME-SRHISETETLKREHYVA-VQLL 2856
Query: 635 RKQLAEKERRIEILESE 651
+++ + I+ L S+
Sbjct: 2857 KEECGTLKAVIQCLRSK 2873
Score = 36.2 bits (82), Expect = 0.11
Identities = 85/527 (16%), Positives = 218/527 (41%), Gaps = 57/527 (10%)
Query: 180 LKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSEN---EMMNEKLDQLDGSF 236
L++ L ++++ LAE +E E+ D T +Q+ K + + E ++ Q DG+
Sbjct: 2721 LQKDLSQVRDHLAEAKEKLSILEKEDE--TEVQESKKACMFEPLPIKLSKSIASQTDGTL 2778
Query: 237 ------DDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEK-QLIEFQHRN 289
P +V LQ E EE + + + +EL ++++ + R+
Sbjct: 2779 KISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRH 2838
Query: 290 -DELTSLAEE----TRALKDEIDVLRATSD--KANKLESTVEIYRQKLQDLNDLRKQVKT 342
E +L E + LK+E L+A ++ + S E+ ++
Sbjct: 2839 ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSG 2898
Query: 343 LQETNMMYMHNTVSLEEELK-KANAARTQLETYKRQVQDLHVKLSSESKRADTLAF---- 397
+Y+ ++ + + + + + +++ ++++ L + +E + +L
Sbjct: 2899 SDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYS 2958
Query: 398 --EMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLA 455
E +++ E L+E++ I +LK+ ++ Q+Q++ + + +S+ +
Sbjct: 2959 DGEDHSIQQVSEPWLEERKAYINTISSLKDLITKM---QLQREAEVYDSSQSHESFSDWR 3015
Query: 456 AEIMPVEYREVFIRLQHENKML------------------------RLQQEGSENERIEE 491
E++ + ++VF L+ + +L R+Q++G E + E
Sbjct: 3016 GELL-LALQQVF--LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAME 3072
Query: 492 LQEQLEQKHRKMNELETEQRLSKERIR-ELQQQIEDLQKSLQEQGSKSEGESSSKLKQKL 550
++ +++ +++ +I + +Q+ E + L E + + +++ +L
Sbjct: 3073 CLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVEL 3132
Query: 551 EAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYL 610
+ ++ TE+ E+L ++ ++ +L+ ++ Q ++ A K ++++A K
Sbjct: 3133 SSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKT 3192
Query: 611 EKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKF 657
++ + TL + + L K+ A+ R E + E + KF
Sbjct: 3193 DEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKF 3239
Score = 30.8 bits (68), Expect = 4.6
Identities = 106/561 (18%), Positives = 221/561 (39%), Gaps = 103/561 (18%)
Query: 117 LGRLLQLILGCAINCEKK---------------QEHIQNIMTLEESVQHVVMTAIQELMS 161
LG L C +N E K Q++ + +E++ ++ +E
Sbjct: 1210 LGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNK 1269
Query: 162 KEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQD----EKNS 217
+L + + G+ +K E E E L + Q+T L+D K+
Sbjct: 1270 LLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL-----SIHSQMTNLEDIDVNHKSK 1324
Query: 218 LVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEE 277
L S ++ KL++ + ++++ Q QL++ E+N+ E +HC
Sbjct: 1325 LSSLQDLEKTKLEE---QVQELESLISS----LQQQLKET-EQNYEAE-------IHC-- 1367
Query: 278 LEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLR 337
L+K+L +++E T +D + T A + ++ + +
Sbjct: 1368 LQKRL----------QAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFS 1417
Query: 338 KQVKTLQETNMMYM---HNTVSLEEELKK-------ANAARTQLETYKRQVQDLHVKLSS 387
+ +ETN++ + LEEE+ K A A +T+L ++ ++
Sbjct: 1418 GEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKEN-----TA 1472
Query: 388 ESKRADTLA------FEMKRLEEKHEALLKEKERLIEQRDTLKETNEEL--RCSQVQQDH 439
SK+A + F +L + + ++ ++ K ++EL ++ +
Sbjct: 1473 SSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSN 1532
Query: 440 LNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQ- 498
+ D +K +E M + + +R +++ + S + E EQLE
Sbjct: 1533 SDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE--EQLEDM 1590
Query: 499 ---------KHRKMNELETEQRLSK-ERIRELQQQIEDLQKSLQEQ-GSKSEGESSSKLK 547
+H++ EL + + + ER RE Q+Q+++ K L Q +S ++ + +
Sbjct: 1591 RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVS 1650
Query: 548 QKLEAHMEKLTEVHE-ELQKKQELIEDLQ------PDINQNVQKINE---LEAALQKKDE 597
++ +E+L + + L +++L +L+ + N+N ++ E E L +K E
Sbjct: 1651 ERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPE 1710
Query: 598 DMK---AMEERYKMYLEKARN 615
D+ ERY L+KA N
Sbjct: 1711 DVPPEILSNERYA--LQKANN 1729
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 98.6 bits (244), Expect = 2e-20
Identities = 96/459 (20%), Positives = 214/459 (46%), Gaps = 40/459 (8%)
Query: 176 LEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGS 235
L ++L+ ++ ++ +K EL+ V L+ E L+S +++ + G
Sbjct: 109 LRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR---LHDSW-KFAGE 164
Query: 236 FDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHR----NDE 291
+ + VA + A +E+L +E L + EEL+++ + Q + E
Sbjct: 165 LEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESE 224
Query: 292 LTSLAEETRALKDEID---------VLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKT 342
+ + + LK +++ L+A +D K +V Q + N+L ++
Sbjct: 225 KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ 284
Query: 343 LQETNMMYMHNTVSLEEEL--KKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMK 400
QE M + EE ++ R Q E +RQ + + K + +R + + +E +
Sbjct: 285 QQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEK-EEKMRRQEEMMWEKE 343
Query: 401 RLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMP 460
+ E + E+E++ EQ + +E E++R +Q+ + +A + E +
Sbjct: 344 EKIRELEEKMHEQEKIREQEEKRQE-EEKIR----EQEKRQEQEAKMWRQEEKI------ 392
Query: 461 VEYREVFIRLQHENKMLRLQQE--GSENERIEELQEQLEQKHRKMNELETEQRLSKERIR 518
RE +++ + +M++ Q+E G + E++ E +E+++++ KM E + R +++IR
Sbjct: 393 ---REQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIR 449
Query: 519 ELQQQIEDLQKSLQEQGSKSEGESSSKL---KQKLEAHMEKLTEVHEELQKKQELIEDLQ 575
E +++I + ++ +QEQ K GE K+ + K++ EK+ E+++++++ I + +
Sbjct: 450 EQEEKIREQEEMMQEQEEKM-GEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQE 508
Query: 576 PDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKAR 614
I + + + E E + +++E M EE+ + EK R
Sbjct: 509 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 547
Score = 96.3 bits (238), Expect = 9e-20
Identities = 91/478 (19%), Positives = 230/478 (48%), Gaps = 35/478 (7%)
Query: 135 QEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEK 194
+ +Q I L + M + + L D + L K A EL++AL+
Sbjct: 114 EAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFA-GELEQALSAV 172
Query: 195 EELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQL 254
+++ + ++T +D + + N + +E+L + + + +V + QL +
Sbjct: 173 ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV 232
Query: 255 EQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATS- 313
++L+ +LE AK + ++L+ E H EL S++ + +A +E ++ +
Sbjct: 233 KELKR---KLERAK--LLLPQQQLQA---EADHLGKELQSVSAKLQAQVEENELWNRLNQ 284
Query: 314 ---DKANKLESTVEIYRQKLQDLND-LRKQVKTLQETNMMYMHNTVSLEEELKKANAART 369
+K + E ++ +K+Q+ + +R+Q + ++ M EE++++
Sbjct: 285 QQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEK----EEKMRRQEEMMW 340
Query: 370 QLETYKRQVQD-LH----VKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLK 424
+ E R++++ +H ++ E ++ + E ++ +E+ + +++E++ EQ + ++
Sbjct: 341 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 400
Query: 425 ETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEG- 483
E E + Q Q++ + + + + E + + + +E IR Q K +R Q+E
Sbjct: 401 EQEEMM---QEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQE--KKIREQEEKI 455
Query: 484 -SENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGES 542
+ E ++E +E++ ++ KM E E + + +E++R +++I + +K ++EQ K +
Sbjct: 456 REQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 515
Query: 543 SSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMK 600
+Q+ EK+ E E++ +++E +++ + + + +K+ E E L++++E M+
Sbjct: 516 EMMQEQE-----EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Score = 92.4 bits (228), Expect = 1e-18
Identities = 93/435 (21%), Positives = 203/435 (46%), Gaps = 49/435 (11%)
Query: 174 GELEQQLKRALEELQEALAEKEELRQRCEELDMQV--TTLQDEKNSLVSENEMMNEKLDQ 231
GELEQ L + ++A EEL + + L +++ T+ DE+ L +N + EKL
Sbjct: 163 GELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE--LKEKNAKLQEKLQL 220
Query: 232 LDGSFDDPNTVVA---KKYFHAQLQL--EQLQEE----NFRLEAAKDDYRVHCEE----- 277
++ + V +K A+L L +QLQ E L++ + EE
Sbjct: 221 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 280
Query: 278 -LEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDL 336
L +Q E R +E + E ++++ + +R +K + E + +K++ ++
Sbjct: 281 RLNQQQEEKMWRQEE--KIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM 338
Query: 337 ----RKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRA 392
++++ L+E MH + E+ +K E KRQ Q+ + E R
Sbjct: 339 MWEKEEKIRELEEK----MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 394
Query: 393 DTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYE 452
+ +++ E+ E + +++E++ EQ + + E EE+ Q Q++ + + + E
Sbjct: 395 -----QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEM---QEQEEKMRRQE-------E 439
Query: 453 NLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRL 512
+ + + +E IR Q E + ++ G + ++ E + +++++ KM E + R
Sbjct: 440 KIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE 499
Query: 513 SKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIE 572
+++IRE +++I + ++ +QEQ K + +Q+ EK+ E E++++++E +
Sbjct: 500 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE-----EKMQEQEEKMRRQEEKMR 554
Query: 573 DLQPDINQNVQKINE 587
+ + + Q +K+ E
Sbjct: 555 EQEVRLRQQEEKMQE 569
Score = 85.1 bits (209), Expect = 2e-16
Identities = 93/469 (19%), Positives = 214/469 (45%), Gaps = 48/469 (10%)
Query: 212 QDEKNSLVSENEMMNEKLD---QLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAK 268
+DE+ + E + +L+ Q T + +++Q ++QL+ E L +
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 155
Query: 269 DDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQ 328
D ELE+ L + + EE L E D L + + ++
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEE---LTKERDALSLELYRNTITDEELKEKNA 212
Query: 329 KLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSE 388
KLQ+ L + K+ + N+ + + + L + + + +++Q + KL ++
Sbjct: 213 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 272
Query: 389 SKRADTLAFEMKRL-EEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASA 447
+ + RL +++ E + +++E++ E+ + ++E E++R Q++ + + +
Sbjct: 273 VEENEL----WNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIR---EQEEKMRRQEEMM 325
Query: 448 TKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHR-----K 502
+ E + R+ + + E K+ L+++ E E+I E +E+ +++ + K
Sbjct: 326 WEKEEKMR--------RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 377
Query: 503 MNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHE 562
E E + +E+IRE +++I + ++ +QEQ ++K+ EK+ E E
Sbjct: 378 RQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ------------EEKMGEQEEKMWEQEE 425
Query: 563 ELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERY-----KMYLEKARNVI 617
E+Q+++E + + I + +KI E E +++++E M+ EE+ KM ++A+ +
Sbjct: 426 EMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAK--M 483
Query: 618 KTLDPKLNPASAEIMLLRKQLAEKERRIEILES--ECKVAKFRDYEEKL 664
+ + K+ +I K++ E+E +I E + + K + EEK+
Sbjct: 484 QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 532
Score = 35.8 bits (81), Expect = 0.14
Identities = 38/236 (16%), Positives = 106/236 (44%), Gaps = 11/236 (4%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEAL 191
E E + I LEE + QE +E + E E ++ R E+++E
Sbjct: 337 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE-- 394
Query: 192 AEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNE---KLDQLDGSFDDPNTVVAKKYF 248
++E++R++ E + Q + +++ + + E M E K+ + + + + ++
Sbjct: 395 -QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEE 453
Query: 249 HAQLQLEQLQEENFRL---EAAKDDYRVHCEELEKQLIEFQHR-NDELTSLAEETRALKD 304
+ Q E +QE+ ++ E + +E E+++ + + ++ + E+ +++
Sbjct: 454 KIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 513
Query: 305 EIDVLRATSDKANKLESTVEIYRQKLQDLND-LRKQVKTLQETNMMYMHNTVSLEE 359
+ ++++ +K + E + +K+Q+ + +R+Q + ++E + ++E
Sbjct: 514 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 34.7 bits (78), Expect = 0.32
Identities = 25/149 (16%), Positives = 74/149 (49%), Gaps = 9/149 (6%)
Query: 132 EKKQEHIQNIMTLEESVQHV---VMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQ 188
E+ QE + + EE ++ + +++ +E + + +GE E ++ ++Q
Sbjct: 425 EEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQ 484
Query: 189 EALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQL---DGSFDDPNTVVAK 245
E ++E++R++ E++ Q +++++ + + EMM E+ +++ + + + +
Sbjct: 485 E---QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 541
Query: 246 KYFHAQLQLEQLQEENFRLEAAKDDYRVH 274
+ + Q E+++E+ RL ++ + H
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 98.6 bits (244), Expect = 2e-20
Identities = 127/594 (21%), Positives = 259/594 (43%), Gaps = 72/594 (12%)
Query: 118 GRLLQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVG--- 174
G + QL +K E ++ + L E Q + + Q+L + E L + + +
Sbjct: 205 GIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ-FQQLQASETLRNSTHSSTAADL 263
Query: 175 -ELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMM-----NEK 228
+ +QQ+ ++L+E E+ +++ E+ MQ++ LQ++ E + E+
Sbjct: 264 LQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE 323
Query: 229 LDQLDGSFDDPNTVVAK----------KYFHAQLQLEQLQEE---------NFRLEA--A 267
+ + + ++ NT + + K A L +LQE+ N +LE +
Sbjct: 324 IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383
Query: 268 KDDYRVHCEELEKQLI----EFQHRN--------DELTSLAEETRALKDEIDVLRATSDK 315
K R EE+ KQL+ E Q RN D + + +ET+ +++ LRA D+
Sbjct: 384 KQKERQSSEEI-KQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR---KLEQLRAELDE 439
Query: 316 A---NKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLE 372
++ E+ RQ + + +++ + K E + N E+++K N A
Sbjct: 440 MYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA----- 494
Query: 373 TYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRC 432
+ +L++KL + + + L E+ + E+ AL ++ E L+E+ +E + R
Sbjct: 495 -----INELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549
Query: 433 SQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKM--LRLQQEGSENERIE 490
+ +Q+ + + E+L AEI+ + L+HE ++ +++ E E E+
Sbjct: 550 TIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609
Query: 491 ELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKL 550
L E + ++ L T+ S E EL + EDL+ + K + KQ++
Sbjct: 610 VLDRMAESQEAELERLRTQLLFSHE--EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQI 667
Query: 551 EAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAAL-QKKDEDMKAMEERYKMY 609
+ ++++ E +Q +++ + Q + + K+ +L+ +L K E+M +
Sbjct: 668 DGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKE 727
Query: 610 LEKARNVIK---TLDPKLNPASAEIMLLRKQLAEKERRIE----ILESECKVAK 656
+E R K TL+ ++ + LL KQ+ EKE ++ LE+E + K
Sbjct: 728 IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781
Score = 94.4 bits (233), Expect = 3e-19
Identities = 127/619 (20%), Positives = 263/619 (42%), Gaps = 66/619 (10%)
Query: 93 LGQQISEALIPDLNQITECSDPVELGRLLQLILGCAINCEKKQEHIQNIMTLEESVQ--H 150
+ ++ A+ L I+E S +E ++ Q L + +KQE +++ EE + H
Sbjct: 1846 ISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL-MRESFRQKQEATESLKCQEELRERLH 1904
Query: 151 VVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEE----LRQRCEELDM 206
A ++L + + D + + +R ++E + + E+ R +EL+
Sbjct: 1905 EESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA 1964
Query: 207 QVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEA 266
+ +Q+E+ L + E M + ++ + K+ Q Q E+++++ L+
Sbjct: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDD---LQK 2021
Query: 267 AKDDYRVHCEELEKQLIEF-QHRNDELTSLAEETRALKDEIDVLRATSDK-ANKLESTVE 324
+ EE + IE Q +N EL L ++ +AL+ +++ +R D+ A E +
Sbjct: 2022 QVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERD 2081
Query: 325 IYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVK 384
+++Q++Q L K V Q + L LK+ ++L K Q+Q
Sbjct: 2082 VFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR---D 2138
Query: 385 LSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLK----ETNEELRCS---QVQQ 437
+ ++ + L F ++ LE+ ALL + + D E EL Q ++
Sbjct: 2139 IQERNEEIEKLEFRVRELEQ---ALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAER 2195
Query: 438 DHLNQTDASATKSYENLAA-------EIMPVEYREVFIRLQHENKMLRLQQEGSENERIE 490
D +++ + T E L + V+ + + +Q + RLQ+ EN+ +
Sbjct: 2196 DAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2255
Query: 491 ELQEQLEQKHRKMNELETEQR-----------LSKE-RIRELQQQIEDLQKSLQEQGSKS 538
+ E+L ++ + + T+ + KE I +L +Q+ LQ+ L+
Sbjct: 2256 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2315
Query: 539 EGESSSKLKQKLEAHMEKLTEVHE--------ELQKKQELIEDLQPDINQNVQKINELEA 590
E ++L + LE +E L E E+++ E+IE LQ ++ QK +
Sbjct: 2316 VIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH 2375
Query: 591 ALQKKDEDMK-----------AMEERYKMYLEKA---RNVIKTLDPKLNPASAEIMLLRK 636
+L ++ + +K A+E++ + E+ +NV+K + K+N + E+ L++
Sbjct: 2376 SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKR 2435
Query: 637 QLAEKERRIEILESECKVA 655
+ E+ I E+ VA
Sbjct: 2436 ERESVEKIQSIPENSVNVA 2454
Score = 75.9 bits (185), Expect = 1e-13
Identities = 122/573 (21%), Positives = 240/573 (41%), Gaps = 98/573 (17%)
Query: 172 AVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMN----- 226
A+ + + + + LQ+A EK+E + EL Q LQ + L + + N
Sbjct: 199 AIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSS 258
Query: 227 ----------------EKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDD 270
++L++ D +D K+ F Q+ Q + + + +E K
Sbjct: 259 TAADLLQAKQQILTHQQQLEEQDHLLEDYQK--KKEDFTMQISFLQEKIKVYEMEQDKKV 316
Query: 271 YRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDK------ANKLESTVE 324
+ EE++++ + N ++ ++T LKD++ T+DK ++ E
Sbjct: 317 ENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKL----TTADKLLGELQEQIVQKNQE 372
Query: 325 IYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVK 384
I KL+ N +K+ ++ +E + + EEL+K N +Q ET Q + +
Sbjct: 373 IKNMKLELTNSKQKERQSSEEIKQL-----MGTVEELQKRNHKDSQFETDIVQRMEQETQ 427
Query: 385 LSSESKRADTLAFEMKRLEEKH-EALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQT 443
E RA+ L+E + + +++ K+ LI Q E +++ H +
Sbjct: 428 RKLEQLRAE--------LDEMYGQQIVQMKQELIRQHMAQME--------EMKTRHKGEM 471
Query: 444 DASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERI-EELQEQLEQK--- 499
+ +A +SY N+ ++ V I ++LQ S+ E++ EEL LE+K
Sbjct: 472 E-NALRSYSNITVNEDQIKLMNVAI----NELNIKLQDTNSQKEKLKEELGLILEEKCAL 526
Query: 500 HRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSK------------SEGESSSKLK 547
R++ +L E S+E+I+ +Q I + + L E S ES +L+
Sbjct: 527 QRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELE 586
Query: 548 QKLEAHMEKLTEVHEELQKKQELIEDLQPDINQ------NVQKINELEAALQKKDEDMKA 601
K EA + E L+K++ + D + + Q + E L K ED
Sbjct: 587 LKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED--- 643
Query: 602 MEERYKMYLEKARNVI-----KTLDPKLNPASAEIMLL---RKQLAEKERRIEILESECK 653
+E +++ +EK ++ + + +D N S +I + + L K+ ++ ILE
Sbjct: 644 LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQL-ILE---- 698
Query: 654 VAKFRDYEEKLIVSAWYNKSLAFQKLGMESRLV 686
++K +D ++ L+ S +L +L E ++
Sbjct: 699 ISKLKDLQQSLVNSKSEEMTLQINELQKEIEIL 731
Score = 75.5 bits (184), Expect = 2e-13
Identities = 97/467 (20%), Positives = 208/467 (44%), Gaps = 64/467 (13%)
Query: 257 LQEENFRL-----EAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETR----------- 300
L+EE F + E D H E +E +L QH +EL EE R
Sbjct: 134 LREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQL 193
Query: 301 -----ALKDE---IDVLRATSDKANK-LESTVEIYRQKLQDLNDLRKQVKTLQETNMMYM 351
A+K I L A +A + + T+ + + + L+ Q + LQ + +
Sbjct: 194 QEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRN 253
Query: 352 HNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLK 411
S +L + A+ Q+ T+++Q+++ L K+ + ++ L+EK +
Sbjct: 254 STHSSTAADLLQ---AKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEM 310
Query: 412 EKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQ 471
E+++ +E + + +E ++ + + + + A+ + E +E ++
Sbjct: 311 EQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370
Query: 472 HENKMLRL------QQEGSENERIEELQ---EQLEQKHRKMNELETE--QRLSKERIREL 520
E K ++L Q+E +E I++L E+L++++ K ++ ET+ QR+ +E R+L
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKL 430
Query: 521 QQQIEDLQKSLQEQGSKSEGESSSKLKQKL-EAHMEKLTEVHEELQKKQELIEDLQPDIN 579
+Q L+ + + G+ ++KQ+L HM ++ E+ + + K E+ L+ N
Sbjct: 431 EQ--------LRAELDEMYGQQIVQMKQELIRQHMAQMEEM--KTRHKGEMENALRSYSN 480
Query: 580 QNVQK---------INELEAALQKKDEDMKAMEERYKMYLEK---ARNVIKTLDPKLNPA 627
V + INEL LQ + + ++E + LE+ + ++ L +L+ +
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
Query: 628 SAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEKLIVSAWYNKSL 674
+I R+ +AE+E ++ E+ ++ D + +++ ++ K L
Sbjct: 541 REQIQRARQTIAEQESKLN--EAHKSLSTVEDLKAEIVSASESRKEL 585
Score = 74.7 bits (182), Expect = 3e-13
Identities = 105/509 (20%), Positives = 224/509 (44%), Gaps = 39/509 (7%)
Query: 145 EESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQE-ALAEKEELRQRCEE 203
+E +Q + ++L + + + + V E E+ L LE L++ +LA +E+L CE
Sbjct: 1623 QEQLQEEIKRLNRQLAQRSSIDN--ENLVSERERVLLEELEALKQLSLAGREKLC--CEL 1678
Query: 204 LDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDD-PNTVVAKKYFHAQLQLEQLQEENF 262
+ T +N E + EK +LD +D P +++ + + Q +L +
Sbjct: 1679 RNSSTQTQNGNENQGEVEEQTFKEK--ELDRKPEDVPPEILSNERYALQKANNRLLK--I 1734
Query: 263 RLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKL-ES 321
LE K V E + + ++ R+ + S A + E V ++ ++ +
Sbjct: 1735 LLEVVKTTAAVE-ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE 1793
Query: 322 TVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDL 381
++ Y ND+ K +E L + L ++ A T+++ + ++L
Sbjct: 1794 SIPSYSGSDMPRNDINMWSKVTEEGT--------ELSQRLVRSGFAGTEIDP---ENEEL 1842
Query: 382 HVKLSSESKRADTLAFEM--KRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDH 439
+ +SS + A E + + A + + E + E +E E L+C + ++
Sbjct: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRER 1902
Query: 440 LNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQK 499
L++ +++ E LA E+ E I + K L +Q + + I+ L+++L
Sbjct: 1903 LHEE----SRAREQLAVELSKAEG---VIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
Query: 500 HRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTE 559
++ ELE EQ+ +E L +Q E ++ + E+ +K+KLE + +
Sbjct: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA-EK 2014
Query: 560 VHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKT 619
V ++LQK+ ++ L+ D+ + V + ELE + D++ + + LEK R K
Sbjct: 2015 VRDDLQKQ---VKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR---KF 2068
Query: 620 LDPKLNPASAEIMLLRKQLAEKERRIEIL 648
LD + E + ++++ + E++++++
Sbjct: 2069 LDEQAIDREHERDVFQQEIQKLEQQLKVV 2097
Score = 73.9 bits (180), Expect = 5e-13
Identities = 106/519 (20%), Positives = 234/519 (45%), Gaps = 77/519 (14%)
Query: 163 EILSSPPNDAVGELEQQLKRALEELQEAL--AEKEELRQRCEELDMQ----VTTLQDE-- 214
E+L N + + + + LE L+ L + +EEL + E+L+++ + L+D
Sbjct: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
Query: 215 ---KNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQL-QLEQLQEENFRLEAAKDD 270
K + M++K++ + F+ N + + ++ +L+ LQ+ + + ++
Sbjct: 661 IHYKQQIDGLQNEMSQKIETMQ--FEKDNLITKQNQLILEISKLKDLQQS--LVNSKSEE 716
Query: 271 YRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVL-RATSDKANKLESTVEIYRQK 329
+ EL+K++ + E +L +E + L+ + ++L + +K N L+ E + Q
Sbjct: 717 MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ---EKFAQL 773
Query: 330 LQDLNDLRKQVKTLQETNMMYMHNTVSLEEEL---------KKANAARTQLETYKRQVQD 380
+ + L+ + KTL++ M+ +H VS EE L K + ++E + +D
Sbjct: 774 EAENSILKDEKKTLED--MLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 381 LH---VKLSSE-SKRADTLAFEMKR-------LEEKHEALLKEKERL--------IEQRD 421
L ++L+ E K+ +T +F K L+E++ LLK K+ L +E +
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKS 891
Query: 422 TLKETNEELRCSQVQQDHLNQT----DASATKSYENLA-AEIMPVEYREVFIRLQ-HENK 475
LK NEEL ++ + D T E L E++ + E+ +L+ + +
Sbjct: 892 KLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKRE 951
Query: 476 MLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQG 535
L L Q R+ +L EQL+QKH +++ L E + K+ ++ + +L+ +
Sbjct: 952 KLELSQ------RLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 536 SKSEGESSSKLKQKLEAHME--------KLTEVHEEL-QKKQELIEDLQPDINQNVQKIN 586
+++ +++ L+ + +++V++ ++ + ++ED N V + +
Sbjct: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
Query: 587 ELEAAL------QKKDEDMKAMEERYKMYLEKARNVIKT 619
+ E + K+ ++A + L+K NV+K+
Sbjct: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS 1104
Score = 73.2 bits (178), Expect = 8e-13
Identities = 114/589 (19%), Positives = 248/589 (42%), Gaps = 89/589 (15%)
Query: 146 ESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELD 205
E +H + +S E+ DA+ E+++ E+L++ E E + ++L
Sbjct: 2171 EDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 2230
Query: 206 MQVTTLQDEKNS----LVSENEMMNEKLDQLDGSFDDPNTV-----------VAKKYFHA 250
MQ+ + E + L EN++ + +++L + + + + A+
Sbjct: 2231 MQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEK 2290
Query: 251 QLQLEQLQEENFRL-----------------EAAKD-DYRVHCEELEKQLIEFQHRNDEL 292
+++++QL E+ +L E +D + ++ C +++ ++ ++R +E+
Sbjct: 2291 EVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK-RNREEEI 2349
Query: 293 TSLAEETRALKDEI-DVLRATSDKANKLESTVEIYRQKLQ----DLNDLRKQVKTLQETN 347
L E L+ E+ ++ + TS A+ L + + +L + L +QV+T E
Sbjct: 2350 EQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE-E 2408
Query: 348 MMYMHNTV---------------SLEEELKKA--------NAARTQLETYKRQVQDLHVK 384
M +M N + SL+ E + N+ ++ + +L V
Sbjct: 2409 MTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVV 2468
Query: 385 LSSESKRADTLAFEMKRLEEKHE-ALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQT 443
L+ ++ ++ K EE + +++ + RL++ T+ + EL Q + +
Sbjct: 2469 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2528
Query: 444 DASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKH-RK 502
T+ + + + +V L + ++ +Q+ + + + + E+ + +
Sbjct: 2529 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588
Query: 503 MNELETEQRLSKE------RIRELQQQIEDLQKSL---QEQGSKSEGESSSKLKQKLEAH 553
+N+L E L + RI EL+ Q+ ++ SL +EQ +E K K+ LE
Sbjct: 2589 LNQLR-EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE-- 2645
Query: 554 MEKLTEVHEELQKKQEL------IEDLQPDI-----NQNVQKINELEAALQKKDEDMKAM 602
++KL E +E+ Q+++E +E L+ N+ NELE AL+ + KA
Sbjct: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELE-ALRAESVATKAE 2704
Query: 603 EERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESE 651
YK EK + + + + ++ +R LAE + ++ ILE E
Sbjct: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE 2753
Score = 72.4 bits (176), Expect = 1e-12
Identities = 119/562 (21%), Positives = 239/562 (42%), Gaps = 83/562 (14%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRA-LEELQEA 190
E+++ +I I +L++ + + + E+ +D GEL L++ LEE
Sbjct: 2982 EERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVL 3041
Query: 191 LAEKEE----------------LRQRCEELDMQVTTLQD-----EKNSLVSENEMMNEKL 229
LA L QR +E ++ + ++ SL+SE + ++
Sbjct: 3042 LAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA-- 3099
Query: 230 DQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRN 289
Q++G + K+ ++ ++L E N + + + + LE Q +E
Sbjct: 3100 -QMNG-----RKITLKREQESEKPSQELLEYNIQQKQS--------QMLEMQ-VELSSMK 3144
Query: 290 DELTSLAEETRALKDEIDVLRATSDKAN-KLESTVEIYRQKLQDLNDLRKQVKTLQETNM 348
D T L E+ + K + L++ + +LE+T++ + L++L R +VK +T+
Sbjct: 3145 DRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK--DKTDE 3202
Query: 349 MYMHNTVSLEEELK-----------KANAARTQLETYKRQVQDLHVKLSSESKRADTLAF 397
+++ N E+ K KA R++ E K +++DL L S+ +R
Sbjct: 3203 VHLLNDTLASEQKKSRELQWALEKEKAKLGRSE-ERDKEELEDLKFSLESQKQRN----L 3257
Query: 398 EMKRLEEKHEALLKEKERLIEQRDTLKET--NEELRCSQVQQDHLNQTDASATKSYENLA 455
++ L E+ + LL E ++ IE + L + +EE + Q L + L
Sbjct: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317
Query: 456 AEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKE 515
E RE+ +LQ + + + + ++ELQ+QLE+KH ++ EL E K
Sbjct: 3318 RE------RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3371
Query: 516 RIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQ 575
+ +QQ+E + ++ L+ E TE +++ + Q +EDLQ
Sbjct: 3372 DSLQTRQQME---------------KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQ 3416
Query: 576 PDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLN-PASAEIMLL 634
+ + Q++ +L+ Q+ M+ +++ ++ E+ R + L LN P + +
Sbjct: 3417 RQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ-ELEREEKRESRRILYQNLNEPTTWSLTSD 3475
Query: 635 RKQLAEKERRIEILESECKVAK 656
R + +++IE E AK
Sbjct: 3476 RTRNWVLQQKIEGETKESNYAK 3497
Score = 65.9 bits (159), Expect = 1e-10
Identities = 112/493 (22%), Positives = 209/493 (42%), Gaps = 69/493 (13%)
Query: 193 EKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQL 252
E EL QR T + E L+ ++ +L + + + + HA++
Sbjct: 1817 EGTELSQRLVRSGFAGTEIDPENEELMLN---ISSRLQAAVEKLLEAISETSSQLEHAKV 1873
Query: 253 QLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELT-----------SLAEETRA 301
+L E+FR + + EEL ++L E ++L A+E
Sbjct: 1874 TQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTL 1933
Query: 302 LKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEEL 361
+ +I + +D ++LE + +LQ+L ++Q++ +E +S ++E
Sbjct: 1934 FERQI---QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL--------LSRQKEA 1982
Query: 362 KKANAARTQL----ETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLI 417
KA A + ET K + L V+ +E R D L ++K LE E ++ R I
Sbjct: 1983 MKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR-DDLQKQVKALEIDVE---EQVSRFI 2038
Query: 418 EQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFI----RLQHE 473
E +E N EL + Q L + K + A + R+VF +L+ +
Sbjct: 2039 ELE---QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID--REHERDVFQQEIQKLEQQ 2093
Query: 474 NKMLRLQQEGSENE--RIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSL 531
K++ Q SE++ +E+L L++K K +EL + + I+E ++IE L+ +
Sbjct: 2094 LKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV 2153
Query: 532 QEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAA 591
+E L+Q L + +V + +K + +P+++ VQ E + A
Sbjct: 2154 RE------------LEQALLVSADTFQKVED---RKHFGAVEAKPELSLEVQLQAERD-A 2197
Query: 592 LQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESE 651
+ +K++++ +EE+ + + E+ N K M L Q E R++ LE E
Sbjct: 2198 IDRKEKEITNLEEQLEQFREELEN-------KNEEVQQLHMQLEIQKKESTTRLQELEQE 2250
Query: 652 CKVAKFRDYEEKL 664
K+ F+D EKL
Sbjct: 2251 NKL--FKDDMEKL 2261
Score = 57.0 bits (136), Expect = 6e-08
Identities = 122/617 (19%), Positives = 248/617 (40%), Gaps = 125/617 (20%)
Query: 149 QHVVMTAIQELMS-KEILSSPPNDAVGELEQQLK-----RALEELQEALAE--------- 193
QHV+ +++ KE+ N+ V +L+QQLK + +EE E + +
Sbjct: 2276 QHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLM 2335
Query: 194 ------KEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKY 247
K + E+L+ + LQ E ++ + M L + S VV +
Sbjct: 2336 SDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEK 2395
Query: 248 FHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRND---ELTSLAEETRAL-- 302
+ Q+E EE ++ + +L ++L + + ++ S+ E + +
Sbjct: 2396 LALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAI 2455
Query: 303 ------KDEIDVLRATSDKANKLE--------------STVEIYRQKLQ----------D 332
K E++V+ T D LE S + + + LQ +
Sbjct: 2456 DHLSKDKPELEVV-LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLE 2514
Query: 333 LNDLRKQVKTLQETNM----MYMHNTVSL----EEELKKANAARTQLET---YKRQVQDL 381
L KQ+K +QE M V+L EE++ A ++ QLE Y + QD
Sbjct: 2515 LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQD- 2573
Query: 382 HVKLSSESKRAD-----------------TLAFEMKRLE----EKHEALLKEKERL-IEQ 419
+ +SSE +R + L + LE E H +L+ EKE++ I +
Sbjct: 2574 NQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAE 2633
Query: 420 RDTLKETNEELRCSQVQQ-DHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENK--- 475
++ L++ + L ++ + + Q + +S ++ VE + L H N+
Sbjct: 2634 KNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQD-------VEVLKTTTELFHSNEESG 2686
Query: 476 ------MLRLQ------QEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQ 523
LR + + S E+ E+LQE+L K M L+ + ++ + E +++
Sbjct: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
Query: 524 IEDLQKSLQEQGSKSEGES-----SSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDI 578
+ L+K + + +S+ KL + + + + ++ Q Q L+++ I
Sbjct: 2747 LSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQI 2806
Query: 579 NQ----NVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLL 634
N + +++ E+ + +K E M+ + + +E +R++ +T K A + LL
Sbjct: 2807 NLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDME-SRHISETETLKREHYVA-VQLL 2864
Query: 635 RKQLAEKERRIEILESE 651
+++ + I+ L S+
Sbjct: 2865 KEECGTLKAVIQCLRSK 2881
Score = 36.2 bits (82), Expect = 0.11
Identities = 85/527 (16%), Positives = 218/527 (41%), Gaps = 57/527 (10%)
Query: 180 LKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSEN---EMMNEKLDQLDGSF 236
L++ L ++++ LAE +E E+ D T +Q+ K + + E ++ Q DG+
Sbjct: 2729 LQKDLSQVRDHLAEAKEKLSILEKEDE--TEVQESKKACMFEPLPIKLSKSIASQTDGTL 2786
Query: 237 ------DDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEK-QLIEFQHRN 289
P +V LQ E EE + + + +EL ++++ + R+
Sbjct: 2787 KISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRH 2846
Query: 290 -DELTSLAEE----TRALKDEIDVLRATSD--KANKLESTVEIYRQKLQDLNDLRKQVKT 342
E +L E + LK+E L+A ++ + S E+ ++
Sbjct: 2847 ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSG 2906
Query: 343 LQETNMMYMHNTVSLEEELK-KANAARTQLETYKRQVQDLHVKLSSESKRADTLAF---- 397
+Y+ ++ + + + + + +++ ++++ L + +E + +L
Sbjct: 2907 SDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYS 2966
Query: 398 --EMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLA 455
E +++ E L+E++ I +LK+ ++ Q+Q++ + + +S+ +
Sbjct: 2967 DGEDHSIQQVSEPWLEERKAYINTISSLKDLITKM---QLQREAEVYDSSQSHESFSDWR 3023
Query: 456 AEIMPVEYREVFIRLQHENKML------------------------RLQQEGSENERIEE 491
E++ + ++VF L+ + +L R+Q++G E + E
Sbjct: 3024 GELL-LALQQVF--LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAME 3080
Query: 492 LQEQLEQKHRKMNELETEQRLSKERIR-ELQQQIEDLQKSLQEQGSKSEGESSSKLKQKL 550
++ +++ +++ +I + +Q+ E + L E + + +++ +L
Sbjct: 3081 CLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVEL 3140
Query: 551 EAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYL 610
+ ++ TE+ E+L ++ ++ +L+ ++ Q ++ A K ++++A K
Sbjct: 3141 SSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKT 3200
Query: 611 EKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKF 657
++ + TL + + L K+ A+ R E + E + KF
Sbjct: 3201 DEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKF 3247
Score = 30.8 bits (68), Expect = 4.6
Identities = 106/561 (18%), Positives = 221/561 (39%), Gaps = 103/561 (18%)
Query: 117 LGRLLQLILGCAINCEKK---------------QEHIQNIMTLEESVQHVVMTAIQELMS 161
LG L C +N E K Q++ + +E++ ++ +E
Sbjct: 1210 LGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNK 1269
Query: 162 KEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQD----EKNS 217
+L + + G+ +K E E E L + Q+T L+D K+
Sbjct: 1270 LLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL-----SIHSQMTNLEDIDVNHKSK 1324
Query: 218 LVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEE 277
L S ++ KL++ + ++++ Q QL++ E+N+ E +HC
Sbjct: 1325 LSSLQDLEKTKLEE---QVQELESLISS----LQQQLKET-EQNYEAE-------IHC-- 1367
Query: 278 LEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLR 337
L+K+L +++E T +D + T A + ++ + +
Sbjct: 1368 LQKRL----------QAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFS 1417
Query: 338 KQVKTLQETNMMYM---HNTVSLEEELKK-------ANAARTQLETYKRQVQDLHVKLSS 387
+ +ETN++ + LEEE+ K A A +T+L ++ ++
Sbjct: 1418 GEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKEN-----TA 1472
Query: 388 ESKRADTLA------FEMKRLEEKHEALLKEKERLIEQRDTLKETNEEL--RCSQVQQDH 439
SK+A + F +L + + ++ ++ K ++EL ++ +
Sbjct: 1473 SSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSN 1532
Query: 440 LNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQ- 498
+ D +K +E M + + +R +++ + S + E EQLE
Sbjct: 1533 SDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE--EQLEDM 1590
Query: 499 ---------KHRKMNELETEQRLSK-ERIRELQQQIEDLQKSLQEQ-GSKSEGESSSKLK 547
+H++ EL + + + ER RE Q+Q+++ K L Q +S ++ + +
Sbjct: 1591 RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVS 1650
Query: 548 QKLEAHMEKLTEVHE-ELQKKQELIEDLQ------PDINQNVQKINE---LEAALQKKDE 597
++ +E+L + + L +++L +L+ + N+N ++ E E L +K E
Sbjct: 1651 ERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPE 1710
Query: 598 DMK---AMEERYKMYLEKARN 615
D+ ERY L+KA N
Sbjct: 1711 DVPPEILSNERYA--LQKANN 1729
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 98.6 bits (244), Expect = 2e-20
Identities = 139/643 (21%), Positives = 283/643 (44%), Gaps = 92/643 (14%)
Query: 104 DLNQITECSDPVELGRLLQLILGCAINCEKKQEHIQN---IMTLEESVQHVVMTAIQELM 160
+++QIT D EL R+L+ EK E IQ+ ++T E V+ QE +
Sbjct: 497 EIHQITRERD--ELQRMLERF-------EKYMEDIQSNVKLLTAERDKLSVLYNEAQEEL 547
Query: 161 S----KEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEEL---------DMQ 207
S + ++ P++ V +E++ + AL +L+ +AEKE LR++ E + +++
Sbjct: 548 SALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELE 607
Query: 208 VT---------TLQDEKNSLVSENEMMNEKLDQLDGSFD---DPNTVVAKKYFHAQLQLE 255
T L+ EK L S+ +M E ++ L+ + VA H + ++
Sbjct: 608 KTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVN 667
Query: 256 QLQEENFRLEAAKDDY-------RVHCEELEKQLIEFQHRNDEL----TSLAEETRALKD 304
L+ N +L+ + DDY R E + Q+ + + DEL TS EE +K
Sbjct: 668 SLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKK 727
Query: 305 EIDVLRATSDKANKLESTVEIYRQKLQDLND-LRKQVKTLQETNMMYMHNTVSLEEELKK 363
I V+ D L+ TV+ +K+ +L + L + K + + +M S+ + +
Sbjct: 728 TIGVIDKEKD---FLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKET 784
Query: 364 ANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTL 423
++ + +RQ+ H +L + + E +RL++ + +E + + + +
Sbjct: 785 LVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAA 844
Query: 424 KETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEG 483
+ EE++ + H T+ S +E+L A E +++ R Q ML + E
Sbjct: 845 VQEKEEMK----SRVHKYITEVS---RWESLMA-AKEKENQDLLDRFQ----MLHNRAED 892
Query: 484 SENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKS--LQEQGSKSEGE 541
E + + + + ++ ++TE+R +ER+ L+++I++ + E S +
Sbjct: 893 WE-VKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAK 951
Query: 542 SSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQK---KDED 598
+ S+L+++L ++ V +L +EL L + Q++N ++ + E+
Sbjct: 952 AMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELEN 1011
Query: 599 MKAMEERYKMYLEKARNVIKTLDPKL--------------NPASAEIMLLRKQLAEKERR 644
+K+ + K L R+ +K L+ L + EI LL+++L E +
Sbjct: 1012 VKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESK 1071
Query: 645 IEILESE-----CKVAKFR-DYE--EKLIVSAWYNKSLAFQKL 679
+ E KVA+ + DY+ ++ I + Y + A Q++
Sbjct: 1072 LTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEM 1114
Score = 76.3 bits (186), Expect = 1e-13
Identities = 126/584 (21%), Positives = 249/584 (42%), Gaps = 61/584 (10%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEAL 191
E + +++ + E S QHV +EL + + + L Q L+ L++
Sbjct: 81 ENNELYLELMKLREHSDQHV-----KELKTSLKKCARETADLKFLNNQYAHKLKLLEKES 135
Query: 192 AEKEELRQRCEELDMQ--VTTLQDEKNSLVSENEMM--NEKLDQLDGSF------DDPNT 241
K E Q+ +E ++ V T +K S+ + M +E + + S DDP
Sbjct: 136 KAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYI 195
Query: 242 -----VVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLA 296
V + Q ++ QLQE+ +E+ DY + IE + R E S+A
Sbjct: 196 ADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDY--------SKQIELREREIERLSVA 247
Query: 297 EETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLN-DLRKQVKTLQETNMMYMHNTV 355
+ D + L + + KL + + I LQ N DL K+++ L ET V
Sbjct: 248 LDGGRSPDVLS-LESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVV 306
Query: 356 SLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKER 415
+L + +K T+++ +Q+ E + + L K L E + + ++
Sbjct: 307 NLSNKNEKLCQELTEIDQLAQQL---------ERHKEEVLETADKELGEAKKEIKRKLSE 357
Query: 416 LIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENK 475
+ + +T+ + EL Q +++ L+ D KS +L + +E + + + E+
Sbjct: 358 MQDLEETMAKLQLELNLCQKEKERLS--DELLVKS--DLETVVHQLEQEKQRLSKKVESF 413
Query: 476 MLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQG 535
+ +Q E ER+ L+ ++++ R + L+T + +E ++++E LQ +Q +
Sbjct: 414 AVTERQLTLEVERMR-LEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRS 472
Query: 536 ---SKSEGESSSKL----KQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKI--- 585
S S E SS K + + ++T +ELQ+ E E DI NV+ +
Sbjct: 473 CSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAE 532
Query: 586 -NELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERR 644
++L + E++ A+ + N++ ++ + A ++ LR+ +AEKE
Sbjct: 533 RDKLSVLYNEAQEELSALRKE-STQTTAPHNIVSLMEKEKELALSD---LRRIMAEKEAL 588
Query: 645 IEILESECKVAKF--RDYEEKLIVSAWYNKSLAFQKLGMESRLV 686
E LE +V+ F + E+ + N L +K ++S+++
Sbjct: 589 REKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVL 632
Score = 63.2 bits (152), Expect = 8e-10
Identities = 102/441 (23%), Positives = 189/441 (42%), Gaps = 67/441 (15%)
Query: 241 TVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETR 300
T V +KY + + +L+QL + V C L ++L +L E R
Sbjct: 3 TAVERKYINIRKRLDQL--------GYRQTLTVECLPLVEKLFS------DLVHTTESLR 48
Query: 301 ALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEE 360
K + ++A + AN + +E Y+ + L+ +E N +Y+ E
Sbjct: 49 QSK--LSAVKAEKESAN-FDFVLEPYKLENARLS---------RENNELYLELMKLREHS 96
Query: 361 LKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQR 420
+ +T L+ R+ DL + + + L E K E+ + L ++ + Q
Sbjct: 97 DQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQT 156
Query: 421 DTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQ 480
K+ + R ++Q D S SY PV Q ++ +
Sbjct: 157 PGGKKRSIAFRRQRMQID--EPVPPSEVSSY--------PVP--------QPDDPYIADL 198
Query: 481 QEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEG 540
+ ++N RI+ELQ+++ Q K+ +E+ R ++I +++IE L +L G +S
Sbjct: 199 LQVADN-RIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVAL--DGGRSPD 255
Query: 541 ----ESSSKLKQKLEAHM----EKLTEVHEELQKK-QELIEDLQPDINQNVQKINELEAA 591
ES +K +KL AH+ + L + +++L+K+ +EL+E + ++ V N+ E
Sbjct: 256 VLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKL 315
Query: 592 LQKKDE-DMKAME-ERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILE 649
Q+ E D A + ER+K V++T D +L A EI ++ + E + L+
Sbjct: 316 CQELTEIDQLAQQLERHK------EEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQ 369
Query: 650 SE---CKVAKFRDYEEKLIVS 667
E C+ K R +E L+ S
Sbjct: 370 LELNLCQKEKERLSDELLVKS 390
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 98.6 bits (244), Expect = 2e-20
Identities = 147/681 (21%), Positives = 285/681 (41%), Gaps = 132/681 (19%)
Query: 117 LGRLLQLILGCAINCEKKQEHIQN-IMTLEESVQHV--VMTAIQELMSKE--ILSSPPND 171
L LQ + C+ + +++Q+ + + + TL++S + MT +Q ++ + L+S ND
Sbjct: 445 LSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNND 504
Query: 172 --AVGELEQQLKRALEELQEALAEKE----ELRQRCEELDMQVTTLQDEKNSLVSENEMM 225
E Q+L +E++Q ++ K+ +LRQ+ L Q+ +Q E+ +L S+ +
Sbjct: 505 LQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKAS 564
Query: 226 NEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQ-----LQEENFRLEAAK-------DDYRV 273
++ L ++++ QL L Q LQ E ++ + + ++
Sbjct: 565 QAEISSLQS---------VRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKL 615
Query: 274 HCEELEKQLIEFQHRN----------------------------DELTSLAEET--RALK 303
L +QL E QHR+ E ++ EE R L+
Sbjct: 616 ENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLE 675
Query: 304 D---EIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEE 360
+ E + L+ +D A LE +E + L + +Q++ LQ+ ++ M +E
Sbjct: 676 EFEGERERLQRMADSAASLEQQLEQVKLTLLQRD---QQLEALQQEHLDLMKQLTLTQEA 732
Query: 361 LKKANAARTQLETYKRQVQDLHVKLSSES-KRADTLAF---EMKRLEEKHEALLKEKERL 416
L+ + L+T+ ++Q +L E+ R DT+ E LE +A KE L
Sbjct: 733 LQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEEL 792
Query: 417 I-----------EQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYRE 465
E +TL++ EEL Q +HL Q A+ K + + + + +
Sbjct: 793 DRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMV 852
Query: 466 VFIRLQHENKMLRLQQEGSENERIE----ELQEQLEQKHRKMNELETEQRLSKERIRELQ 521
R +K + + + +R++ EL+++L Q H + E E + +++
Sbjct: 853 EAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVR 912
Query: 522 QQIEDLQKSLQE-QGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKK-QELIEDLQPDIN 579
Q + DL+ LQ Q + E E+ + Q + M +TE +E L+K+ +EL ++ + I
Sbjct: 913 QHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAIT 972
Query: 580 QNVQKINELEAALQKKDEDMKAMEERYK-------------MYLEKARNV---------- 616
+ QK+ L + L ++MK + Y+ + ++A +
Sbjct: 973 EQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGG 1032
Query: 617 -----------IKTLDPKLNPASAEIMLLRKQLAE---------KERRIEILESECKVAK 656
I+ L+ +L S LL K+L E +E R ++LE E ++ +
Sbjct: 1033 SSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQE 1092
Query: 657 FRDYEEKLIVSAWYNKSLAFQ 677
R + +K+ NK LA +
Sbjct: 1093 SRGFRKKIKRLEESNKKLALE 1113
Score = 97.8 bits (242), Expect = 3e-20
Identities = 141/676 (20%), Positives = 288/676 (42%), Gaps = 107/676 (15%)
Query: 75 ASNVKKVLQGIMSYYHEFLGQQISEALIPDLN--------QITECS--DPVELGRLLQLI 124
A + LQG M+ H +GQ L+ L Q+TE E GR+ +
Sbjct: 585 AQEARVRLQGEMA--HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQL 642
Query: 125 LGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRAL 184
G + ++ I + V+ + ++E + D+ LEQQL++
Sbjct: 643 QGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVK 702
Query: 185 EELQEALAEKEELRQRCEELDMQVTTLQDEKNS-------LVSENEMMNEKLDQLDGSFD 237
L + + E L+Q +L Q+T Q+ S L + + + +L +L G
Sbjct: 703 LTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAA 762
Query: 238 DPNTVVA-----KKYFHAQLQL-----EQLQEENFRLEAAKDDYRVHCEELEKQLI---- 283
+ K A LQ E+L RLE ++ E+L ++L
Sbjct: 763 SREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSG 822
Query: 284 EFQHRNDELTSLAEETRALKDE-------IDVLRATSDKANKLESTVEIYRQKL-QDLND 335
+ +H E +L ++ + +K++ ++ R + ++L S ++ R++L +L +
Sbjct: 823 QVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKE 882
Query: 336 LRKQV------KTLQETNMMYMHNTVS--------LEEELKKANAARTQLETYKRQVQDL 381
LR+++ K E + +H V+ LE L+ A R ++ET+ + +Q
Sbjct: 883 LRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFD 942
Query: 382 HVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLN 441
++ + ++ + L +++ L++ + ++ + EQ+ ++ +L +Q +
Sbjct: 943 KEQMVAVTEANEALKKQIEELQQ------EARKAITEQKQKMRRLGSDLTSAQKEM---- 992
Query: 442 QTDASATKSYENLAAEIMPVEYREVFIRLQ---HENKMLRLQQEGSE-----NERIEELQ 493
+ K+YEN A I+ +E + E LR Q S+ +ERI+ L+
Sbjct: 993 ---KTKHKAYEN-AVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALE 1048
Query: 494 EQLEQKHRKMNELETEQR----LSKERIRELQQQIEDLQKSLQEQGS-----KSEGESSS 544
+L+ LE E + L+ + + E ++++ +L+ LQE K ES+
Sbjct: 1049 AELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNK 1108
Query: 545 KLKQKLEAHMEKLT---EVHEELQKKQELIEDLQPDINQNVQKIN-ELEAALQKKDED-- 598
KL +LE KLT + + L++ ++E ++ ++N +++A LQ+K+E+
Sbjct: 1109 KLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDR 1168
Query: 599 -MKAMEERYKMYLEKARNVIKTLDPKL--------------NPASAEIMLLRKQLAEKER 643
MK + + + LEK + + +L ++ AS E+ ++K+L KE
Sbjct: 1169 QMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEH 1228
Query: 644 RIEILESECKVAKFRD 659
++ L++E + R+
Sbjct: 1229 LVQKLQAEADDLQIRE 1244
Score = 90.9 bits (224), Expect = 4e-18
Identities = 134/624 (21%), Positives = 261/624 (41%), Gaps = 68/624 (10%)
Query: 77 NVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAINCEKKQE 136
++K VLQ + H+ GQ+++ + + I CS + L A E+ +
Sbjct: 360 SIKDVLQAAAAE-HQDQGQEVNGEVRSRRDSI--CSS-------VSLESSAAETQEEMLQ 409
Query: 137 HIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEE 196
++ M LE ++ + + A Q L K EL+ QL +LQ +
Sbjct: 410 VLKEKMRLEGQLEALSLEASQALKEK-----------AELQAQLAALSTKLQAQVECSHS 458
Query: 197 LRQRCEELDMQVTTLQ----DEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQL 252
+QR + L +V TL+ D + ++ M+ K L S +D V ++Y
Sbjct: 459 SQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQ-VAEEQYQRLMA 517
Query: 253 QLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRAT 312
++E +Q + D R L+ QL + Q LTS L+A+
Sbjct: 518 KVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTS-------------KLKAS 564
Query: 313 SDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLE 372
+ + L+S + Y+Q+L + R +++ + L E LK N + +Q
Sbjct: 565 QAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQL 624
Query: 373 TYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRC 432
T + H + + + A L + ++ A ++ +E + L+ EE
Sbjct: 625 T-----ETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEG 679
Query: 433 SQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHEN--KMLRLQQEG--SENER 488
+ + + + AS + E + ++ + + ++ +H + K L L QE S +
Sbjct: 680 ERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQS 739
Query: 489 IEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQ--EQGSKSEGESSSKL 546
++ LQ ++ ++ EL+ E ++ I LQ + L+ +LQ + G + + +L
Sbjct: 740 LDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRL 799
Query: 547 KQKLEAHMEKLTEVHEELQKKQELIEDLQPD---INQNVQKINE--------LEAALQ-- 593
++ E E L ++ EEL K +E LQ + + + +QKI E +EA +
Sbjct: 800 EEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDA 859
Query: 594 -KKDE---DMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILE 649
KD+ ++KA +R L++ R + + + A AE+ L +++A+ + + LE
Sbjct: 860 TSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLE 919
Query: 650 SECKVA-KFRDYEEKLIVSAWYNK 672
+ A K RD E + S ++K
Sbjct: 920 GHLQSAQKERDEMETHLQSLQFDK 943
Score = 82.8 bits (203), Expect = 1e-15
Identities = 118/562 (20%), Positives = 245/562 (43%), Gaps = 54/562 (9%)
Query: 122 QLILGCAINCEK--KQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQ 179
++IL A+ K K+E + LEE + T +++L + + S + + +
Sbjct: 775 KIILEAALQAAKSGKEELDRGARRLEEGTEETSET-LEKLREELAIKSGQVEHLQQETAA 833
Query: 180 LKRALEELQEALAEK----EELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGS 235
LK+ +++++E ++ E R+ D ++ L+ + L SE + + ++L Q+ G
Sbjct: 834 LKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGE 893
Query: 236 FDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSL 295
+++ + ++ Q+++ LE + +E+E L Q +++ ++
Sbjct: 894 KRTAEAELSRLH----REVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAV 949
Query: 296 AEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDL-NDLRKQVKTLQETNMMYMHNT 354
E ALK +I+ L+ + KA + +QK++ L +DL K ++ + Y +
Sbjct: 950 TEANEALKKQIEELQQEARKA------ITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAV 1003
Query: 355 VSLEEELKKANAARTQLETYKRQVQD----------LHVKLSSESKRADTLAFEMKRLE- 403
L L++A AA+ + Q++ LH ++ + ++ LE
Sbjct: 1004 GILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEK 1063
Query: 404 EKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEY 463
E E + + L E R+ + E +EL+ S+ + + + + S K L E
Sbjct: 1064 ELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHE------ 1117
Query: 464 REVFIRLQHENKMLRLQQEGSEN---ERIEELQEQLEQKHRKMNELETEQRLSKERIREL 520
+ L N LR E +R +L + Q + E E R K ++ L
Sbjct: 1118 KGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQAL 1177
Query: 521 QQQIEDLQK---SLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQEL------- 570
Q +E ++ SL+EQ + ++ E+ + A +E L+EV +ELQ K+ L
Sbjct: 1178 QASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLE-LSEVKKELQAKEHLVQKLQAE 1236
Query: 571 IEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEK---ARNVIKTLDPKLNPA 627
+DLQ ++ Q+I + +A L + ++ ++++ L K ++ L +++
Sbjct: 1237 ADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQK 1296
Query: 628 SAEIMLLRKQ--LAEKERRIEI 647
EI L++Q L E++ R E+
Sbjct: 1297 EREIQSLKQQLDLTEQQGRKEL 1318
Score = 70.1 bits (170), Expect = 7e-12
Identities = 109/528 (20%), Positives = 215/528 (40%), Gaps = 64/528 (12%)
Query: 183 ALEELQEALAEKEE-LRQRCEELDMQVTTLQDEKNSLVS-ENEMMNEKLDQLDGSFDDPN 240
A ++QEA EE L++R EE + + LQ +S S E ++ KL L D
Sbjct: 655 AFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQR--DQQL 712
Query: 241 TVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETR 300
+ +++ QL QE E + D + H +EL+ +L E Q E S +
Sbjct: 713 EALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQ---GEAASREDTIC 769
Query: 301 ALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEE 360
L++E +L A A + ++ ++L++ + + +TL++ + +E
Sbjct: 770 LLQNEKIILEAALQAAKSGKEELDRGARRLEEGTE--ETSETLEKLREELAIKSGQVEHL 827
Query: 361 LKKANAARTQLETYKRQVQDLHVKLSSESKRA---DTLAFEMKRLEEKHEALLKEKERLI 417
++ A + Q++ K Q V + + + A D L E+K ++ ++ LKE
Sbjct: 828 QQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKEL---- 883
Query: 418 EQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKML 477
R L + + E R ++ + L++ A + +L + + + ++
Sbjct: 884 --RQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQF 941
Query: 478 RLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSK 537
+Q + E E L++Q+E+ ++ + TEQ K+++R L + QK ++ +
Sbjct: 942 DKEQMVAVTEANEALKKQIEELQQEARKAITEQ---KQKMRRLGSDLTSAQKEMKTKHKA 998
Query: 538 SE-------------------------------GESSSKLK-----QKLEAHMEKLTEVH 561
E G S S L Q LEA ++ ++
Sbjct: 999 YENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSK 1058
Query: 562 EELQKK-QELIEDLQPDINQNVQKINELEAALQ------KKDEDMKAMEERYKMYLEKAR 614
L+K+ QE+I ++ ++ +K+ ELE LQ KK + ++ ++ + LE +
Sbjct: 1059 TLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEK 1118
Query: 615 NVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEE 662
+ L +L LA++E + L + + R EE
Sbjct: 1119 GKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEE 1166
Score = 68.9 bits (167), Expect = 2e-11
Identities = 96/466 (20%), Positives = 200/466 (42%), Gaps = 44/466 (9%)
Query: 132 EKKQEHIQNIMTLEESVQHVVMTAIQELMSKEI--LSSPPNDAVGELEQQLKRALEELQE 189
++ + H+Q++ +E Q V +T E + K+I L A+ E +Q+++R +L
Sbjct: 930 DEMETHLQSLQFDKE--QMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTS 987
Query: 190 ALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFH 249
A ++E++ + + + V L ++ E + +L QL ++ +A
Sbjct: 988 A---QKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALH--- 1041
Query: 250 AQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIE-FQHRNDELTSLAEETRALKDEIDV 308
E++Q L+A + LEK+L E + EL E+ L+DE+
Sbjct: 1042 -----ERIQALEAELQAVSHSKTL----LEKELQEVIALTSQELEESREKVLELEDELQE 1092
Query: 309 LRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAAR 368
R K +LE E ++ +L + ++ L ++N + LE L K A
Sbjct: 1093 SRGFRKKIKRLE---ESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADL 1149
Query: 369 TQLETYKRQVQDLHVKLSSESKRADTLAFEMKR-LEEKHEALLKEKERLIEQRDTLKETN 427
QL QVQ + + E ++ L ++ LE++ E + KE++ +
Sbjct: 1150 VQLNL---QVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNR 1206
Query: 428 EELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENE 487
+ + ++ + + + + L AE ++ RE +H ++ + Q E +E
Sbjct: 1207 RHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREG----KHSQEIAQFQAELAEAR 1262
Query: 488 RI-----EELQEQLEQK---HRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSE 539
++L EQL ++ +++M L+ E + I+ L+QQ++ L EQ + E
Sbjct: 1263 AQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD-----LTEQQGRKE 1317
Query: 540 GESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKI 585
E +L Q +++ +E E QK + +++ ++ N++ +
Sbjct: 1318 LEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTL 1363
Score = 39.7 bits (91), Expect = 0.010
Identities = 72/320 (22%), Positives = 140/320 (43%), Gaps = 39/320 (12%)
Query: 341 KTLQETNMMYMHNTVSLEEE-LKKANAARTQLETYKRQVQDLHVKLSSESK-RADTL--- 395
KT+ + YM N + + L + + + L+ + QD +++ E + R D++
Sbjct: 334 KTVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSS 393
Query: 396 -AFEMKRLEEKHEAL--LKEKERLIEQRDTLKETNEELRCSQVQQDHLN---QTDASATK 449
+ E E + E L LKEK RL Q + L L SQ ++ Q A +TK
Sbjct: 394 VSLESSAAETQEEMLQVLKEKMRLEGQLEALS-----LEASQALKEKAELQAQLAALSTK 448
Query: 450 SYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENER-IEELQEQLEQKHRKMNELET 508
+ + ++ +++ L+Q + ER + +LQ LE K+ +
Sbjct: 449 LQAQVECSHSSQQRQDSL-----SSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNN 503
Query: 509 EQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQ 568
+ ++++E+ + L ++ED+Q+S+ S+ + L+Q++ A +L +V E
Sbjct: 504 DLQVAEEQYQRLMAKVEDMQRSM-----LSKDNTVHDLRQQMTALQSQLQQVQLERTTLT 558
Query: 569 ELIEDLQPDIN--QNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVI--KTLDPKL 624
++ Q +I+ Q+V++ + + AL A E R ++ E A + T L
Sbjct: 559 SKLKASQAEISSLQSVRQWYQQQLAL--------AQEARVRLQGEMAHIQVGQMTQAGLL 610
Query: 625 NPASAEIMLLRKQLAEKERR 644
E + L +QL E + R
Sbjct: 611 EHLKLENVSLSQQLTETQHR 630
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 98.2 bits (243), Expect = 2e-20
Identities = 135/650 (20%), Positives = 276/650 (42%), Gaps = 61/650 (9%)
Query: 41 VAMAQVLHQIDAAWFNESWLSRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFLGQQIS-- 98
V +A+ ++ N S L E G + A++++ LQ E Q+++
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 99 ---EALIPDLNQITECSDPVELGR------LLQLILGCAINCEKKQEHIQNIMTLEESVQ 149
L + N + E + E R +L L A +K + + I +LEE+ +
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 150 HVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVT 209
++ A E +S+ + A +LE+ R +EL + + + RQ L+ +
Sbjct: 1396 KLLKDA--EALSQRLEEKAL--AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK-- 1449
Query: 210 TLQDEKNSLVSENEMMN----EKLDQLDGSFDDPNTV---VAKKYFHAQLQLEQLQEENF 262
Q + + L++E + ++ E+ D+ + + T +A+ A E+ + +N
Sbjct: 1450 --QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK 1507
Query: 263 RLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEI-DVLRATSDKANKLES 321
+L A +D +++ K + E + L EE R +E+ D L+AT D +LE
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE- 1566
Query: 322 TVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQ-- 379
V + K Q DL+ + + +E + + LE EL+ R K++++
Sbjct: 1567 -VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625
Query: 380 --DLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTL----KETNEELRCS 433
DL ++ + +K D + ++++L+ + + +E E RD + KE+ ++L+
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL 1685
Query: 434 QVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQ 493
+ + L + AS+ ++ + E + I K L ++ RI +L+
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADE---ITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 494 EQLEQKHRKMNELETE-----------------QRLSKERIRELQQQIEDLQKSLQEQGS 536
E+LE++ M L +R + ++ +QQ+E K L+ +
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 537 KSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKD 596
+ EG SK K + A K+ ++ E+L+++ + + + +K+ E+ +Q +D
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEI--FMQVED 1860
Query: 597 EDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIE 646
E A ++YK +EKA +K L +L A E + +R ++
Sbjct: 1861 ERRHA--DQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD 1908
Score = 91.7 bits (226), Expect = 2e-18
Identities = 140/668 (20%), Positives = 280/668 (41%), Gaps = 66/668 (9%)
Query: 23 QTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDNWRIKASNVKKVL 82
+T N + QD++Q A+ ++ Q++ A ++ L + K+ + + + A VK VL
Sbjct: 1186 ETKNHEAQIQDMRQ-RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK-VL 1243
Query: 83 QGIMSYYHEFLGQQISEALIPDLN-QITECSDPVELGRLLQLILGCAINCEKKQEHIQNI 141
Q + + SE L+ Q+ E V G L++ L A K Q + N+
Sbjct: 1244 QQVKAE---------SEHKRKKLDAQVQELHAKVSEGDRLRVEL--AEKASKLQNELDNV 1292
Query: 142 MTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRC 201
TL E + + ++ S E + + E +Q +++ EK L+++
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Query: 202 EE-------LDMQVTTLQD---EKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQ 251
EE L+ QV LQ + V ++ E L++ ++++
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 252 LQLEQLQEENFRLEAAKDDYRV---HCEELEKQLIEFQHRNDELTSLAEE---TRALKDE 305
L ++L++ RL+ DD V H ++ L + Q + D+L LAEE + +E
Sbjct: 1413 LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL--LAEEKSISARYAEE 1470
Query: 306 IDVLRATS-DKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEEL-KK 363
D A + +K K S + L+ + +Q K L+ M + +S ++++ K
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRAD----MEDLMSSKDDVGKN 1526
Query: 364 ANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTL 423
+ ++QV+++ +L RLE +A+ + ER ++ RD
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 424 KETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLR--LQQ 481
E + L QV++ D ++ + + M ++ +++ +++ NK ++Q
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646
Query: 482 EGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSL--QEQGSKSE 539
++++ Q +LE+ +E+ + + S+++++ L+ +I LQ+ L E+ +
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1706
Query: 540 GESSSKL-----------------KQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNV 582
+ +L K++LEA + +L E EE Q EL+ D V
Sbjct: 1707 EQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQV 1766
Query: 583 QKIN-ELEA---ALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQL 638
+N EL A A QK D + +E + K K + + + K A I L ++
Sbjct: 1767 DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF---KATISALEAKI 1823
Query: 639 AEKERRIE 646
+ E ++E
Sbjct: 1824 GQLEEQLE 1831
Score = 91.3 bits (225), Expect = 3e-18
Identities = 119/572 (20%), Positives = 248/572 (43%), Gaps = 63/572 (11%)
Query: 173 VGELEQQLKRALEELQEALAE-------KEELRQRCEELDMQVTTLQDE-------KNSL 218
+ EL+ QL + EELQ ALA K + EL Q+ LQ++ +N
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 219 VSENEMMNEKLDQLDGSFDDP-NTVVAKKYFHAQLQLE------QLQEENFRLEAAKDDY 271
+ ++E+L+ L +D +T A++ + + E L+EE EA D
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 272 RVH----CEELEKQLIEFQHRNDELTS----LAEETRALKDEIDVLRA----TSDKANKL 319
R EEL +QL + + L L + + L E+ VL+ + K KL
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 320 ESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEEL-KKANAARTQLETYKRQV 378
++ V+ K+ + + LR ++ + N +L EE KK + + Q+
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317
Query: 379 QDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQD 438
QD L E+++ L+ +++LEE+ +L +++E E+ + K +++ Q Q
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE---EEEEARKNLEKQVLALQSQL- 1373
Query: 439 HLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQ 498
A K ++ I +E + + E RL+++ +++E+ + +L+Q
Sbjct: 1374 ------ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 499 KHRKMNELETEQRLSKERIRELQQQIEDL---QKSLQ----EQGSKSEGESSSK------ 545
+ + QR + + Q++ + L +KS+ E+ ++E E+ K
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1487
Query: 546 LKQKLEAHMEKLTEVHEELQKKQELIEDL---QPDINQNVQKINELEAALQKKDEDMKAM 602
L + LE +E E + ++ + +EDL + D+ +NV ++ + + AL+++ E+M+
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547
Query: 603 EERYKMYLEKARNVIKTLDPKLNPASAEI---MLLRKQLAEKERRIEILESECKVAKFRD 659
E + L+ + L+ + A+ + R + E+++R+ I + A+ D
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 660 YEEKLIVSAWYNKSLAFQKLGMESRLVSGGGA 691
++ ++ K + +E+++ + A
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Score = 90.5 bits (223), Expect = 5e-18
Identities = 125/593 (21%), Positives = 258/593 (43%), Gaps = 99/593 (16%)
Query: 133 KKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDA---VGELEQQLKRALEELQE 189
KKQE + + LE V+ +E +IL + + +LE+QL Q+
Sbjct: 916 KKQELEEILHDLESRVE-------EEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQK 968
Query: 190 ALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFH 249
EK + ++++ ++ L+D+ + + E ++M +++ +
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS--------------- 1013
Query: 250 AQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDEL----TSLAEETRALKDE 305
QL + +E+ L ++ V +LE++L + + EL L ET L+D+
Sbjct: 1014 ---QLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070
Query: 306 IDVLRATSD--------KANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSL 357
I L+A D K +L+ + + N+ K V+ LQ L
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA-------QIAEL 1123
Query: 358 EEELKKANAARTQLETYKRQVQDLHVKLSSE---------------SKRADTLAFEMKRL 402
+E+ + A+R + E KR + + L +E +KR +A K L
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 403 EEK---HEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIM 459
EE+ HEA +++ + L+E +E+L ++ + +L + + LA E+
Sbjct: 1184 EEETKNHEAQIQDMRQ--RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 460 PVEYREVFIRLQHENKML--RLQQEGSENERIEELQEQLEQKHRKM-NELETEQRLSKER 516
++ +V +H+ K L ++Q+ ++ + L+ +L +K K+ NEL+ L +E
Sbjct: 1242 VLQ--QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299
Query: 517 IRE----------LQQQIEDLQKSLQEQGSKSEGESSSKLKQ------KLEAHMEKLTEV 560
++ L+ Q++D Q+ LQE+ ++ + SS+++Q L+ E+ E
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEE-TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 561 HEELQKK----QELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYK---MYLEKA 613
+ L+K+ Q + D + ++ ++ I LE A +K +D +A+ +R + + +K
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 614 RNVIKTLDPKLNPASAEIMLLRK---QLAEKERRIEILESECKVAKFRDYEEK 663
L +L+ + ++ R+ L +K+++ + L +E K R EE+
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471
Score = 88.2 bits (217), Expect = 2e-17
Identities = 95/417 (22%), Positives = 200/417 (47%), Gaps = 50/417 (11%)
Query: 173 VGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQ- 231
V ELE+ KRALE+ + EE+R + EEL+ ++ +D K L + M + ++
Sbjct: 1527 VHELEKS-KRALEQ------QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERD 1579
Query: 232 ---LDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHR 288
D ++ ++ K+ + +LE +++ A+K + ++LE Q+
Sbjct: 1580 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 289 NDELTSLAEETRA-LKD---EIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQ 344
DE+ + +A +KD E++ RA+ D EI+ Q + K++K+L+
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRD---------EIFAQSKES----EKKLKSLE 1686
Query: 345 ETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEE 404
+ L+EEL + AR E + ++ D ++++ + L E +RLE
Sbjct: 1687 A-------EILQLQEELASSERARRHAEQERDELAD---EITNSASGKSALLDEKRRLEA 1736
Query: 405 KHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQ---TDASATKSYENLAAEIMPV 461
+ L +E L E++ ++ N+ R + +Q D LN + SA + +N A + +
Sbjct: 1737 RIAQL---EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDN-ARQQLER 1792
Query: 462 EYREVFIRLQHENKMLRLQQEGSENE---RIEELQEQLEQKHRKMNELETEQRLSKERIR 518
+ +E+ +LQ ++ + + + + +I +L+EQLEQ+ ++ R ++++++
Sbjct: 1793 QNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLK 1852
Query: 519 ELQQQIEDLQKSLQEQGSKSEGESS--SKLKQKLEAHMEKLTEVHEELQKKQELIED 573
E+ Q+ED ++ + + E ++ +LK++LE E+ T + +K Q ++D
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Score = 87.4 bits (215), Expect = 4e-17
Identities = 117/582 (20%), Positives = 255/582 (43%), Gaps = 93/582 (15%)
Query: 177 EQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNE---KLDQLD 233
E++L+ EEL + ++ ++ EE++ + L +EKN L + + E + +++
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 234 GSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQ--HRNDE 291
+ + + ++E+ +E N L+ K + H ++LE+QL E + + +
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 292 LTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQD----LNDLRKQVKTLQETN 347
L + E + K E ++L D+ +K ++ ++ + L + ++ K L +
Sbjct: 971 LEKVTAEAKIKKMEEEIL-LLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIR 1029
Query: 348 MMYMHNTVSLEEELKKANAARTQLETYKRQVQ----DLHVKLSSESKRADTLAFEM-KRL 402
LEE LKK R +LE KR++ DL +++ + D L ++ K+
Sbjct: 1030 NKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKE 1089
Query: 403 EEKHEALLKEKERLIEQRDTLKETNE-ELRCSQVQQDHLNQTDA--SATKSYENLAAEI- 458
EE AL + + + + + LK E + + +++Q+D ++ + A K +L+ E+
Sbjct: 1090 EELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELE 1149
Query: 459 -MPVEYREVF--------IRLQHENKMLRLQQEGSENER----------------IEELQ 493
+ E + +R + E ++ L++ E + +EEL
Sbjct: 1150 ALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELS 1209
Query: 494 EQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSK---------------S 538
EQLEQ R LE ++ + +EL +++ LQ+ E K S
Sbjct: 1210 EQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS 1269
Query: 539 EGE----SSSKLKQKLEAHMEKLTEVHEELQKK-----------QELIEDLQPDINQNVQ 583
EG+ ++ KL+ ++ ++ + EE +KK + ++D Q + + +
Sbjct: 1270 EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETR 1329
Query: 584 KINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKER 643
+ L + +++ +E+ +++E+ + E +N+ K +++ L+ QLA+ ++
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK-----------QVLALQSQLADTKK 1378
Query: 644 RIE----ILES--ECKVAKFRDYEEKLIVSAWYNKSLAFQKL 679
+++ +ES E K +D E + K+LA+ KL
Sbjct: 1379 KVDDDLGTIESLEEAKKKLLKDAE--ALSQRLEEKALAYDKL 1418
Score = 65.9 bits (159), Expect = 1e-10
Identities = 94/410 (22%), Positives = 174/410 (42%), Gaps = 41/410 (10%)
Query: 291 ELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMY 350
++T EE +A +E L +K K+E +E +K Q L L+E N++
Sbjct: 846 QVTRQEEELQAKDEE---LLKVKEKQTKVEGELEEMERKHQQL---------LEEKNILA 893
Query: 351 MHNTVSLEEEL-KKANAARTQLETYKRQVQ----DLHVKLSSESKRADTLAFEMKRLEEK 405
+ E EL +A R +L K++++ DL ++ E +R L E K+++
Sbjct: 894 --EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAH 951
Query: 406 HEALLKE--KERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEY 463
+ L ++ +E Q+ L++ E + +++++ L D ++ E ++M
Sbjct: 952 IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK---KLMEDRI 1008
Query: 464 REVFIRL-QHENKMLRLQQEGSENE-RIEELQEQLEQKHRKMNELETEQRLSKERIRELQ 521
E +L + E K L + ++ E I +L+E+L+++ + ELE +R +LQ
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 522 QQIEDLQKSLQE---QGSKSEGESSSKLKQKLE--AHMEKLTEVHEELQKKQELIEDLQP 576
QI +LQ + E Q +K E E L + + H +V ELQ + I +LQ
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ---IAELQE 1125
Query: 577 DINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRK 636
D N+ E K+ D+ E K LE + E+ L+K
Sbjct: 1126 DFESEKASRNKAE----KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Query: 637 QLAEKERRIEILESECK---VAKFRDYEEKLIVSAWYNKSLAFQKLGMES 683
L E+ + E + + + E+L + + +L K G+E+
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET 1231
Score = 47.4 bits (111), Expect = 5e-05
Identities = 42/165 (25%), Positives = 81/165 (49%), Gaps = 7/165 (4%)
Query: 527 LQKSLQEQGSKSEGESSSKLKQK---LEAHMEKLTEVHEE-LQKKQELIEDLQPDINQNV 582
LQ + QE+ +++ E K+K+K +E +E++ H++ L++K L E LQ + +
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE-TELF 903
Query: 583 QKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKE 642
+ E+ A L K ++++ + + +E+ + L + A I L +QL E+E
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 643 --RRIEILESECKVAKFRDYEEKLIVSAWYNKSLAFQKLGMESRL 685
R+ LE AK + EE++++ N +K ME R+
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008
Score = 43.9 bits (102), Expect = 5e-04
Identities = 49/248 (19%), Positives = 102/248 (41%), Gaps = 24/248 (9%)
Query: 178 QQLKRALEELQEALAEKEELRQRCE----ELDMQVTTLQDEKNSLVSENEMMNEKLDQLD 233
+ L+ + +LQE LA E R+ E EL ++T K++L+ E + ++ QL+
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 234 GSFDDPNT---VVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRND 290
++ + ++ ++ LQ++ L E +A ++LE+Q E + +
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 291 EL------------TSLAEETRALKDEIDVLRATSDKANKL-----ESTVEIYRQKLQDL 333
EL ++L + L+++++ ANKL + EI+ Q +
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER 1862
Query: 334 NDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRAD 393
+ + +++ N LEE ++A A +R++ D S+
Sbjct: 1863 RHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVS 1922
Query: 394 TLAFEMKR 401
TL ++R
Sbjct: 1923 TLKNRLRR 1930
Score = 38.9 bits (89), Expect = 0.017
Identities = 38/185 (20%), Positives = 77/185 (41%), Gaps = 8/185 (4%)
Query: 132 EKKQEHIQNIMTLEESVQHVVM---TAIQELMSKEILSSPPNDAVGELEQQ---LKRALE 185
E+ +E N+ L + + + T EL ++ + ++A +LE+Q LK L+
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 186 ELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAK 245
EL+ A+ K + + L+ ++ L+++ E N+ + + + + V
Sbjct: 1803 ELEGAV--KSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVED 1860
Query: 246 KYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDE 305
+ HA EQ+++ N R++ K EE + + EL E L E
Sbjct: 1861 ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSRE 1920
Query: 306 IDVLR 310
+ L+
Sbjct: 1921 VSTLK 1925
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 97.8 bits (242), Expect = 3e-20
Identities = 128/586 (21%), Positives = 256/586 (43%), Gaps = 52/586 (8%)
Query: 135 QEHIQNIMTLEE-------SVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEEL 187
+EH+ N M +E SV + +EL + L A+ +LE++ +
Sbjct: 453 EEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKN 512
Query: 188 QEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENE---MMNEKLDQLDGSFDDPNTVVA 244
E + + + L+ V +L+D+ L N+ + EK++QL D+ N ++
Sbjct: 513 AEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLR 572
Query: 245 ----------KKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQ-----HRN 289
K + Q++QL+ N L+ +LEK+ I Q R
Sbjct: 573 TESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERR 632
Query: 290 DELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQD-LNDLRKQVKTLQETNM 348
D T +E L+ I L L + VE+ +++LQ+ DL K+ K+ E +M
Sbjct: 633 DR-THGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKE-KSNMEIDM 690
Query: 349 MYMHNTV--SLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKH 406
Y + SLE+E + A + +L + + + S K + E + L++K
Sbjct: 691 TYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKV 750
Query: 407 EALLKEKERLIEQRDT-LKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYRE 465
E LL E E+ D LK++ +++ Q+D LN+ + T E + + +
Sbjct: 751 ENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQ-ETQKRCLTQND 809
Query: 466 VFIRLQHENKM-LRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQI 524
+ ++ Q N + + +Q EN + E++ LE+++ EL E++ + +++ELQ Q+
Sbjct: 810 LKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNA---ELRKERQDADGQMKELQDQL 866
Query: 525 EDLQK-----SLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELI------ED 573
E Q Q + K E E +KL ++L+ ++L + + L + E+ E
Sbjct: 867 EAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQ 926
Query: 574 LQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIML 633
L I + ++ ++LE K+ ++K M R+K L + I +L+ ++++
Sbjct: 927 LARSIAE--EQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVAN 984
Query: 634 LRKQLAEKERRIEILESECKVAKFRDYE-EKLIVSAWYNKSLAFQK 678
L + E +++ ++ + +++ +D E + A + K L ++
Sbjct: 985 LANEKEELNNKLKDVQEQ--LSRLKDEEISAAAIKAQFEKQLLTER 1028
Score = 90.1 bits (222), Expect = 6e-18
Identities = 124/562 (22%), Positives = 243/562 (43%), Gaps = 100/562 (17%)
Query: 165 LSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEM 224
+ S N+ E++++L E L + KEEL Q+C+ ++ ++ E ++ +
Sbjct: 434 IQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKS 493
Query: 225 MNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIE 284
+ L QL+ ++ K Q + + ++ LE + + E+L+K+
Sbjct: 494 VESALRQLERE----KALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQN 549
Query: 285 FQHRNDELTSL---AEETRAL----KDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLR 337
Q +++ L +ET AL D LR T +++K +E + LQD N L
Sbjct: 550 SQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLL 609
Query: 338 KQVKTLQETNMMYMHNTV----------------------SLEEELKKANAARTQLETYK 375
+ K E + + + + LEE+LK ++E K
Sbjct: 610 ETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEK 669
Query: 376 RQVQDLHVKLSSESKRAD-TLAFEMKRL-----------------------------EEK 405
RQ+Q+ L E + + +++K + E K
Sbjct: 670 RQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAK 729
Query: 406 HEALLKEKERLIEQRDTLKETNEEL------RCSQVQQDHLNQTDASATKSYENLAAEIM 459
EA+ + +++L+E+R TLK+ E L RCS + D L Q+ + + +++
Sbjct: 730 SEAMKEMEKKLLEER-TLKQKVENLLLEAEKRCSLLDCD-LKQSQQKINELLKQ--KDVL 785
Query: 460 PVEYREVFIRLQHENKMLRLQQEG--SENERIEEL---QEQLEQKHRKMNELETEQRLSK 514
+ R + ++++ E + L Q + +++ L ++QL+Q++ + E++
Sbjct: 786 NEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQN 845
Query: 515 ERIRELQQQIEDLQKSLQEQGSKSEGESSSKLK---QKLEAHMEKLTEVHEELQKKQELI 571
+R+ +Q + K LQ+Q ++E S+ K ++L+ E+ T++ +ELQ+K++ +
Sbjct: 846 AELRKERQDADGQMKELQDQ-LEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQEL 904
Query: 572 EDLQPDINQNVQKINELEAALQKKDEDMKA---MEERYKMYLEKARNVIKTLDPKLNPAS 628
+D + + +LE L K D + A EE+Y LEK + ++K L+ K
Sbjct: 905 QDERDSL------AAQLEITLTKADSEQLARSIAEEQYS-DLEKEK-IMKELEIK----- 951
Query: 629 AEIMLLRKQ-LAEKERRIEILE 649
E+M KQ L EK+ I LE
Sbjct: 952 -EMMARHKQELTEKDATIASLE 972
Score = 75.9 bits (185), Expect = 1e-13
Identities = 99/498 (19%), Positives = 213/498 (42%), Gaps = 79/498 (15%)
Query: 132 EKKQEHIQNIMTLE-ESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEA 190
EK++ +++ MT + + +Q + E + + + N +E+ A++E+++
Sbjct: 680 EKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKK 739
Query: 191 LAEKEELRQ-----------RCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDP 239
L E+ L+Q RC LD + Q + N L+ + +++NE + L
Sbjct: 740 LLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLT------ 793
Query: 240 NTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLI---EFQHRNDELTSLA 296
L++EQ E +K+ + + + + ++ +L
Sbjct: 794 ------------LKIEQ--------------------ETQKRCLTQNDLKMQTQQVNTLK 821
Query: 297 EETRALKDEIDVLRATSDKANKLESTVEIYRQKLQ-DLNDLRKQVKTLQETNMMYMHNTV 355
+ LK E + L K + + RQ + +L+ Q++ Q + +Y
Sbjct: 822 MSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVR 881
Query: 356 SLEEELKKANAARTQLETYKRQVQDLHVKLSSESK----RADTLAFEMKRLEEKHEALLK 411
L+EE ++ +L+ K+++QD L+++ + +AD+ EE++ L K
Sbjct: 882 ELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEK 941
Query: 412 EK-ERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRL 470
EK + +E ++ + +EL L +T+ + T NLA E +
Sbjct: 942 EKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANE-----------KE 990
Query: 471 QHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKE---RIRELQQQIEDL 527
+ NK+ +Q++ S + E ++ + K +L TE+ L + ++ E+ + E +
Sbjct: 991 ELNNKLKDVQEQLSRLKDEEISAAAIKAQFEK--QLLTERTLKTQAVNKLAEIMNRKEPV 1048
Query: 528 QKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINE 587
++ + E E+ KL +L++ EKLT+ ++ K Q+ + ++Q I + Q E
Sbjct: 1049 KRGNDTDVRRKEKENR-KLHMELKSEREKLTQ---QMIKYQKELNEMQAQIAEESQIRIE 1104
Query: 588 LEAALQKKDEDMKAMEER 605
L+ L KD D++ + +
Sbjct: 1105 LQMTLDSKDSDIEQLRSQ 1122
Score = 61.2 bits (147), Expect = 3e-09
Identities = 88/416 (21%), Positives = 176/416 (42%), Gaps = 57/416 (13%)
Query: 322 TVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEEL-KKANAARTQLETYKRQVQD 380
T I +K ++ +++K++ TL+E ++ N + +EEL +K + T+LE ++++
Sbjct: 431 TDSIQSRKNEESQEIQKKLYTLEE----HLSNEMQAKEELEQKCKSVNTRLEKTAKELE- 485
Query: 381 LHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHL 440
E L + E+ L++ ER ++ L+ N E Q + DH
Sbjct: 486 -----------------EEITLRKSVESALRQLER---EKALLQHKNAEY---QRKADH- 521
Query: 441 NQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKH 500
+A ++ EN ++ Q E+ R Q E++ +LQ QL++ +
Sbjct: 522 ---EADKKRNLENDVNS----------LKDQLEDLKKRNQNSQISTEKVNQLQRQLDETN 568
Query: 501 RKM-NELETEQRLSKERIRELQ--QQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKL 557
+ E +T RL K + + QQ+E + LQ++ E + KL+++ L
Sbjct: 569 ALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLE-TAKLKLEKEFINLQSAL 627
Query: 558 TEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNV- 616
+ E+I DLQ I + + + L K + + + ++ER+ ++ N+
Sbjct: 628 ESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNME 687
Query: 617 ------IKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEKLIVSAWY 670
+K + L AE + +LA+K + E +E E K ++ E+KL+
Sbjct: 688 IDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIE-EAKSEAMKEMEKKLLEERTL 746
Query: 671 NKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSVKVPATT 726
+ + + L +E+ C + L Q+ + RNL++K+ T
Sbjct: 747 KQKV--ENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQET 800
Score = 39.3 bits (90), Expect = 0.013
Identities = 40/191 (20%), Positives = 86/191 (45%), Gaps = 25/191 (13%)
Query: 156 IQELMSKEILSSPPNDA-VGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDE 214
I+E+M++ DA + LE+ + ++ EKEEL + +++ Q++ L+DE
Sbjct: 950 IKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDE 1009
Query: 215 KNS-----------LVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFR 263
+ S L++E + + +++L + V + + ++EN +
Sbjct: 1010 EISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGN----DTDVRRKEKENRK 1065
Query: 264 LEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTV 323
L R E+L +Q+I++Q +E+ + E ++ E+ + + D S +
Sbjct: 1066 LHMELKSER---EKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKD------SDI 1116
Query: 324 EIYRQKLQDLN 334
E R +LQ L+
Sbjct: 1117 EQLRSQLQALH 1127
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 97.4 bits (241), Expect = 4e-20
Identities = 114/515 (22%), Positives = 219/515 (42%), Gaps = 48/515 (9%)
Query: 173 VGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQL 232
V L +++ E + + EK+ L++ ++ + +D+ N L+ N + ++ D L
Sbjct: 979 VKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL 1038
Query: 233 DGSFDDPNTVVA-----KKYFHAQLQL----------------EQLQEENF---RLEAAK 268
+GS + + A K+ L++ E+L+++ F +L+A
Sbjct: 1039 EGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKI 1098
Query: 269 DDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQ 328
DD +VH + +K++ E Q R +EL E L+ +I+ R SD A +LE E +
Sbjct: 1099 DDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQR--SDLARELEEISE-RLE 1155
Query: 329 KLQDLNDLRKQVKTLQETNMMYMHNTV---SLEEELKKANAARTQLETYK---RQVQDLH 382
+ + ++ +E M + +L+ E A + Q ++ Q+ +L
Sbjct: 1156 EASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215
Query: 383 VKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQ 442
K L E+ + EAL K K + T+++ E++ QQ L
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275
Query: 443 TDASATKSYENLAAEIM-PVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHR 501
+ E+ VE +E I ++K QQ +EEL+ Q+E++ +
Sbjct: 1276 DLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQ-------LEELKRQMEEETK 1328
Query: 502 KMNELETEQRLSKERIRELQQQIEDLQKS---LQEQGSKSEGESSSKLKQKLEAHMEKLT 558
N + + S+ L++Q E+ Q++ LQ SK+ E ++ + K E + T
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSE-VAQWRTKYETDAIQRT 1387
Query: 559 EVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIK 618
E EE +KK L + LQ + +N + N A+L+K + ++ E LE++
Sbjct: 1388 EELEEAKKK--LAQRLQ-EAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACA 1444
Query: 619 TLDPKLNPASAEIMLLRKQLAEKERRIEILESECK 653
TLD K + +++L E + +E + E +
Sbjct: 1445 TLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESR 1479
Score = 97.4 bits (241), Expect = 4e-20
Identities = 119/546 (21%), Positives = 240/546 (43%), Gaps = 57/546 (10%)
Query: 139 QNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELR 198
++IM LE Q + ++L KE S + + + + ++++E A EEL
Sbjct: 1068 ESIMDLENDKQQIE----EKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE 1123
Query: 199 QRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQ 258
+ E ++ +++ L E E ++E+L++ G+ + K+ Q L+
Sbjct: 1124 EEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 259 EENFRLEAAK------------------DDYRVHCEELEKQLIEFQHRNDELTSLAEETR 300
E + EA D+ + ++LEK+ E + D++ S E
Sbjct: 1184 EATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALS 1243
Query: 301 ALKDEID-VLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEE 359
K I+ R D+ +++++ E Q + DLN + +++T + SL
Sbjct: 1244 KSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLIS 1303
Query: 360 ELKKANAART-QLETYKRQVQDLHVKLSSESKRADTLAFEMKR-----LEEKHEALLKEK 413
+L K+ A T QLE KRQ+++ +++K A A + R L E++E +E+
Sbjct: 1304 QLTKSKQALTQQLEELKRQMEE-----ETKAKNAMAHALQSSRHDCDLLREQYE---EEQ 1355
Query: 414 ERLIEQRDTLKETNEELR--CSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIR-- 469
E E + L + N E+ ++ + D + +T+ ++ + LA + E
Sbjct: 1356 EAKAELQRALSKANSEVAQWRTKYETDAIQRTE-ELEEAKKKLAQRLQEAEENTETANSK 1414
Query: 470 -LQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQ 528
E RLQ E +E+L LE+ H L+ +QR + + E +Q++++ Q
Sbjct: 1415 CASLEKTKQRLQGE------VEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQ 1468
Query: 529 KSLQ--EQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDI---NQNVQ 583
L+ ++ S+S K++ E +++L + E + QE I DL I +N+Q
Sbjct: 1469 AELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQ 1528
Query: 584 KINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKER 643
+ + + ++++ D++ E + LE + I + +L+ +E L +++ EK+
Sbjct: 1529 EAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSE---LDRKVIEKDE 1585
Query: 644 RIEILE 649
IE L+
Sbjct: 1586 EIEQLK 1591
Score = 95.9 bits (237), Expect = 1e-19
Identities = 127/501 (25%), Positives = 212/501 (42%), Gaps = 64/501 (12%)
Query: 175 ELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDG 234
ELE+ K+ + LQEA E +C L+ LQ E L+ + E + LD
Sbjct: 1389 ELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDK 1448
Query: 235 SFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTS 294
+ + V+A+ ++L E LEAA+ + R EL K ++ D+L +
Sbjct: 1449 KQRNFDKVLAE-------WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 295 LAEETRALKDEI----DVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTL---QETN 347
L E + L++EI + + T + E T ++ Q+ DL ++V+ +E+
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Query: 348 MMYMHNTVS-LEEEL-KKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEK 405
++ + +S ++ EL +K ++E KR Q L S + RL++K
Sbjct: 1562 ILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKK 1621
Query: 406 HEALLKEKE-RLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYR 464
E L E E +L + ET + LR Q Q A +S E+L ++ VE R
Sbjct: 1622 MEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERR 1681
Query: 465 EVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQI 524
G E +EE++ LEQ R +RLS++ + + ++
Sbjct: 1682 N-----------------GLLLEELEEMKVALEQTER-------TRRLSEQELLDASDRV 1717
Query: 525 EDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKL-TEVHEELQKKQELIEDLQPDINQNVQ 583
+ L S+ S K+KLEA + + EV +Q+ + E + I
Sbjct: 1718 QLLH---------SQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAM 1768
Query: 584 KINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLL---RKQLAE 640
EL KK++D A ER K LE+ +K L +L+ AE + L +KQ+ +
Sbjct: 1769 MAEEL-----KKEQDTSAHLERMKKNLEQ---TVKDLQHRLD--EAEQLALKGGKKQIQK 1818
Query: 641 KERRIEILESECKVAKFRDYE 661
E R+ LE+E V + R E
Sbjct: 1819 LENRVRELENELDVEQKRGAE 1839
Score = 91.7 bits (226), Expect = 2e-18
Identities = 110/520 (21%), Positives = 225/520 (43%), Gaps = 64/520 (12%)
Query: 175 ELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSL----VSENEMMNEKLD 230
E E+++ E+ + E R +EL+ ++ +L EKN L SE E + + +
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEE 907
Query: 231 QLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQ---- 286
+ +G ++ K +LE+ +E N L A K + C L++ + + +
Sbjct: 908 RCEGLIKS-KILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLT 966
Query: 287 -------HRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQ 339
+++ +L+EE AL++ I L T +K +S E ++Q L DL +
Sbjct: 967 KVEKEKHATENKVKNLSEEMTALEENISKL--TKEK----KSLQEAHQQTLDDLQVEEDK 1020
Query: 340 VKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSES---------- 389
V L + N T LE L++ R LE KR+++ +K+S ES
Sbjct: 1021 VNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEG-DLKMSQESIMDLENDKQQ 1079
Query: 390 --KRADTLAFEMKRLEEKHE----ALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQT 443
++ FE+ +L+ K + L+ ++++ E + ++E EE+ + + +
Sbjct: 1080 IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ 1139
Query: 444 DASATKSYENL-----------AAEIMPVEYREV-FIRLQHENKMLRLQQEGS------- 484
+ + E + +A+I + RE F +++ + + LQ E +
Sbjct: 1140 RSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 485 ENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQ--EQGSKSEGES 542
+ + + EL EQ++ R +LE E+ K I ++ IE L KS E+ ++ +
Sbjct: 1200 QADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQ 1259
Query: 543 SSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAM 602
S++K K E+ T++ +L ++ ++ +++ V++ L + L K + +
Sbjct: 1260 FSEIKAK----DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQ 1315
Query: 603 EERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKE 642
E K +E+ + L + + LLR+Q E++
Sbjct: 1316 LEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQ 1355
Score = 90.5 bits (223), Expect = 5e-18
Identities = 110/516 (21%), Positives = 213/516 (41%), Gaps = 54/516 (10%)
Query: 171 DAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLD 230
D+V EL +Q+ Q+ EK EL+ +++ + L K+++ + ++
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFS 1261
Query: 231 QLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRND 290
++ + ++ +Q +LQ +N L ++ +L K + +
Sbjct: 1262 EIKAKDEQQTQLI----HDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLE 1317
Query: 291 ELT-SLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLND-LRKQVKTLQETNM 348
EL + EET+A L+++ + L E ++ +L L K + +
Sbjct: 1318 ELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRT 1377
Query: 349 MYMHNTVSLEEELKKANAARTQ-LETYKRQVQDLHVKLSSESKRADTLAFE----MKRLE 403
Y + + EEL++A Q L+ + + + K +S K L E M+ LE
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE 1437
Query: 404 EKHEAL--LKEKER-----LIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAA 456
H A L +K+R L E + L E+ EL +Q + L+ +YE +
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 457 EIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKER 516
++ L+ ENK L+ E I +L EQ+ + + + E E ++L ++
Sbjct: 1498 QLET---------LRRENKNLQ--------EEISDLTEQIAETGKNLQEAEKTKKLVEQE 1540
Query: 517 IRELQQQIEDLQKSLQEQGSK------SEGESSSKLKQKLEAHMEKLTEVHEELQKKQEL 570
+LQ +E+++ SL+ + SK + S+L +K+ +EK E+ + + Q
Sbjct: 1541 KSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKV---IEKDEEIEQLKRNSQRA 1597
Query: 571 IEDLQPDINQNVQKINELEAALQKKDEDMKAME----------ERYKMYLEKARNVIKTL 620
E LQ ++ ++ N+ +K + D+ ME + +L + +K
Sbjct: 1598 AEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDS 1657
Query: 621 DPKLNPASAEIMLLRKQLAEKERRIEILESECKVAK 656
L+ A L++QLA ERR +L E + K
Sbjct: 1658 QLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMK 1693
Score = 70.5 bits (171), Expect = 5e-12
Identities = 85/382 (22%), Positives = 176/382 (46%), Gaps = 51/382 (13%)
Query: 280 KQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQ 339
K L++ E+ ++ E+ K+E+ R+ + + E V + LQ+ NDL+ Q
Sbjct: 841 KPLLKSAEAEKEMATMKEDFERTKEEL--ARSEARRKELEEKMVSL----LQEKNDLQLQ 894
Query: 340 VKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEM 399
V++ E N + EE + ++ LE +V++L +L E + L +
Sbjct: 895 VQSETE-------NLMDAEERCEGLIKSKILLEA---KVKELTERLEEEEEMNSELVAKK 944
Query: 400 KRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIM 459
+ LE+K +L ++ + L TL + +E ++ + +L++ + ++ L E
Sbjct: 945 RNLEDKCSSLKRDIDDL---ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKK 1001
Query: 460 PVE--YREVFIRLQHENKMLR--LQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKE 515
++ +++ LQ E + ++ ++ ++L+ LEQ+ + +LE +R +
Sbjct: 1002 SLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEG 1061
Query: 516 RIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQ 575
++ Q+ I DL+ KQ++E EKL + EL + Q I+D Q
Sbjct: 1062 DLKMSQESIMDLEND----------------KQQIE---EKLKKKEFELSQLQAKIDDEQ 1102
Query: 576 PDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARN--------VIKTLDPKLNPA 627
Q +KI EL+A +++ +E+++A E + +EK R+ + + L+
Sbjct: 1103 VHSLQFQKKIKELQARIEELEEEIEA-EHTLRAKIEKQRSDLARELEEISERLEEASGAT 1161
Query: 628 SAEIMLLRKQLAEKERRIEILE 649
SA+I + +K+ AE ++ LE
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLE 1183
Score = 62.8 bits (151), Expect = 1e-09
Identities = 89/414 (21%), Positives = 175/414 (42%), Gaps = 48/414 (11%)
Query: 173 VGELEQQLKRALEELQEALAEKE--------ELRQRCEELDMQVTTLQDEKNSLVSENEM 224
V + + L+ ALEE++ +L +E EL Q ELD +V +E L ++
Sbjct: 1537 VEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQR 1596
Query: 225 MNEKLDQ-LDGSFDDPNTVV-AKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQL 282
E L LD N + KK L ++Q + + A + + H ++ QL
Sbjct: 1597 AAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMA--ETQKHLRTVQGQL 1654
Query: 283 IEFQ-HRNDELTSLAEETRALKDEIDV--------LRATSDKANKLESTVEIYRQKLQDL 333
+ Q H +D L S LK+++ + L + LE T R Q+L
Sbjct: 1655 KDSQLHLDDALRS----NEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQEL 1710
Query: 334 NDLRKQVKTLQETNMMYMHNTVSLEEELKKANA--------ARTQLETYKRQVQDLHVKL 385
D +V+ L N ++ LE ++ + A +R E K+ + D +
Sbjct: 1711 LDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMA 1770
Query: 386 SSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQ---QDHLNQ 442
K DT A ++R+++ E +K+ + +++ + L + + +++ ++ N+
Sbjct: 1771 EELKKEQDTSA-HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENE 1829
Query: 443 TDASATKSYENL-AAEIMPVEYREVFIRLQHENK-MLRLQQEGSENERIEELQEQLEQKH 500
D + E L A + +E+ + + ++K +LRLQ + +++LQ +++
Sbjct: 1830 LDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQ------DLVDKLQAKVKSYK 1883
Query: 501 RKMNELETEQRLSKERIRELQQQIEDLQKS---LQEQGSKSEGESSSKLKQKLE 551
R+ E E + R R +Q ++E+ + + Q +K +S QK+E
Sbjct: 1884 RQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
Score = 52.4 bits (124), Expect = 1e-06
Identities = 64/326 (19%), Positives = 140/326 (42%), Gaps = 29/326 (8%)
Query: 130 NCEKKQEHIQNIMTLEESVQHVVMTAIQ----ELMSKEILSSPPNDAVGELEQQLKRALE 185
N ++ E +Q+++ E ++ + + +L EI N + E ++ L+
Sbjct: 1593 NSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG 1652
Query: 186 ELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAK 245
+L+++ ++ + E+L Q+ ++ L+ E E M L+Q + + + +
Sbjct: 1653 QLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERT----RRLSEQ 1708
Query: 246 KYFHAQLQLEQLQEENFRLEAAKDDYR---VHCE-ELEKQLIEFQHRNDE----LTSLAE 297
+ A +++ L +N L K C+ E+E + E ++ ++ +T A
Sbjct: 1709 ELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAM 1768
Query: 298 ETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDL-----RKQVKTLQETNMMYMH 352
LK E D LE TV+ + +L + L +KQ++ L E + +
Sbjct: 1769 MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL-ENRVRELE 1827
Query: 353 NTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKE 412
N + +E+ K+ A Y+R+V+++ + + K L + +L+ K ++ ++
Sbjct: 1828 NELDVEQ--KRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQ 1885
Query: 413 KERLIEQRDTLKETNEELRCSQVQQD 438
E EQ +T + RC +VQ +
Sbjct: 1886 AEEAEEQANT-----QLSRCRRVQHE 1906
Score = 48.1 bits (113), Expect = 3e-05
Identities = 46/206 (22%), Positives = 95/206 (46%), Gaps = 11/206 (5%)
Query: 463 YREVFIRLQHENKMLRLQQE-GSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQ 521
+ +F +++ K ++E + E E +E+L + + ELE + + +LQ
Sbjct: 833 WMNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQ 892
Query: 522 QQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTE-VHEELQKKQELI---EDLQPD 577
Q++ ++L + + EG SK+ LEA +++LTE + EE + EL+ +L+
Sbjct: 893 LQVQSETENLMDAEERCEGLIKSKI--LLEAKVKELTERLEEEEEMNSELVAKKRNLEDK 950
Query: 578 INQNVQKINELEAALQKKDEDMKAMEERYKMYLEK----ARNVIKTLDPKLNPASAEIML 633
+ + I++LE L K +++ A E + K E+ N+ K K + A
Sbjct: 951 CSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQT 1010
Query: 634 LRKQLAEKERRIEILESECKVAKFRD 659
L E+++ +++ K+ + D
Sbjct: 1011 LDDLQVEEDKVNGLIKINAKLEQQTD 1036
Score = 33.1 bits (74), Expect = 0.94
Identities = 27/120 (22%), Positives = 60/120 (50%), Gaps = 5/120 (4%)
Query: 543 SSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAM 602
S++ ++++ E EEL + + ++L+ + +Q+ N+L+ +Q + E++
Sbjct: 846 SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905
Query: 603 EERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEE 662
EER + L K++ +++ +L E + +L K+R LE +C K RD ++
Sbjct: 906 EERCE-GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRN---LEDKCSSLK-RDIDD 960
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.339
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,206,191
Number of Sequences: 37866
Number of extensions: 1145120
Number of successful extensions: 27785
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 677
Number of HSP's successfully gapped in prelim test: 1410
Number of HSP's that attempted gapping in prelim test: 7541
Number of HSP's gapped (non-prelim): 8172
length of query: 728
length of database: 18,247,518
effective HSP length: 110
effective length of query: 618
effective length of database: 14,082,258
effective search space: 8702835444
effective search space used: 8702835444
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.