Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 139948432
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|139948432 adlican [Homo sapiens]
(2828 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|139948432 adlican [Homo sapiens] 5705 0.0
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 940 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 328 4e-89
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 309 3e-83
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 307 1e-82
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 307 1e-82
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 245 5e-64
gi|110349719 titin isoform N2-A [Homo sapiens] 225 5e-58
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 208 7e-53
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 177 2e-43
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 174 1e-42
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 171 7e-42
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 171 7e-42
gi|109150416 peroxidasin [Homo sapiens] 171 7e-42
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 171 1e-41
gi|19743806 roundabout 1 isoform b [Homo sapiens] 168 6e-41
gi|4506569 roundabout 1 isoform a [Homo sapiens] 168 6e-41
gi|224994173 roundabout 1 isoform d [Homo sapiens] 156 3e-37
gi|224994171 roundabout 1 isoform c [Homo sapiens] 156 3e-37
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 156 3e-37
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 156 3e-37
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 152 6e-36
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 152 6e-36
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 151 8e-36
gi|7657359 contactin 5 isoform long [Homo sapiens] 150 1e-35
gi|28373129 contactin 5 isoform short [Homo sapiens] 150 1e-35
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 147 1e-34
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 147 2e-34
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 145 4e-34
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 140 1e-32
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 5705 bits (14801), Expect = 0.0
Identities = 2828/2828 (100%), Positives = 2828/2828 (100%)
Query: 1 MPKRAHWGALSVVLILLWGHPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERI 60
MPKRAHWGALSVVLILLWGHPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERI
Sbjct: 1 MPKRAHWGALSVVLILLWGHPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERI 60
Query: 61 NLGFNSIQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITG 120
NLGFNSIQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITG
Sbjct: 61 NLGFNSIQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITG 120
Query: 121 QTLQGLSNLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYF 180
QTLQGLSNLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYF
Sbjct: 121 QTLQGLSNLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYF 180
Query: 181 RLSTIRHLYLAENMVRTLPASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILK 240
RLSTIRHLYLAENMVRTLPASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILK
Sbjct: 181 RLSTIRHLYLAENMVRTLPASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILK 240
Query: 241 CKKDKAYEGGQLCAMCFSPKKLYKHEIHKLKDMTCLKPSIESPLRQNRSRSIEEEQEQEE 300
CKKDKAYEGGQLCAMCFSPKKLYKHEIHKLKDMTCLKPSIESPLRQNRSRSIEEEQEQEE
Sbjct: 241 CKKDKAYEGGQLCAMCFSPKKLYKHEIHKLKDMTCLKPSIESPLRQNRSRSIEEEQEQEE 300
Query: 301 DGGSQLILEKFQLPQWSISLNMTDEHGNMVNLVCDIKKPMDVYKIHLNQTDPPDIDINAT 360
DGGSQLILEKFQLPQWSISLNMTDEHGNMVNLVCDIKKPMDVYKIHLNQTDPPDIDINAT
Sbjct: 301 DGGSQLILEKFQLPQWSISLNMTDEHGNMVNLVCDIKKPMDVYKIHLNQTDPPDIDINAT 360
Query: 361 VALDFECPMTRENYEKLWKLIAYYSEVPVKLHRELMLSKDPRVSYQYRQDADEEALYYTG 420
VALDFECPMTRENYEKLWKLIAYYSEVPVKLHRELMLSKDPRVSYQYRQDADEEALYYTG
Sbjct: 361 VALDFECPMTRENYEKLWKLIAYYSEVPVKLHRELMLSKDPRVSYQYRQDADEEALYYTG 420
Query: 421 VRAQILAEPEWVMQPSIDIQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIE 480
VRAQILAEPEWVMQPSIDIQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIE
Sbjct: 421 VRAQILAEPEWVMQPSIDIQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIE 480
Query: 481 PSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWL 540
PSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWL
Sbjct: 481 PSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWL 540
Query: 541 RIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCN 600
RIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCN
Sbjct: 541 RIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCN 600
Query: 601 ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD 660
ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD
Sbjct: 601 ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD 660
Query: 661 HFTVGITVTKKGSGLPSKRGRRPGAKALSRVREDIVEDEGGSGMGDEENTSRRLLHPKDQ 720
HFTVGITVTKKGSGLPSKRGRRPGAKALSRVREDIVEDEGGSGMGDEENTSRRLLHPKDQ
Sbjct: 661 HFTVGITVTKKGSGLPSKRGRRPGAKALSRVREDIVEDEGGSGMGDEENTSRRLLHPKDQ 720
Query: 721 EVFLKTKDDAINGDKKAKKGRRKLKLWKHSEKEPETNVAEGRRVFESRRRINMANKQINP 780
EVFLKTKDDAINGDKKAKKGRRKLKLWKHSEKEPETNVAEGRRVFESRRRINMANKQINP
Sbjct: 721 EVFLKTKDDAINGDKKAKKGRRKLKLWKHSEKEPETNVAEGRRVFESRRRINMANKQINP 780
Query: 781 ERWADILAKVRGKNLPKGTEVPPLIKTTSPPSLSLEVTPPFPAISPPSASPVQTVTSAEE 840
ERWADILAKVRGKNLPKGTEVPPLIKTTSPPSLSLEVTPPFPAISPPSASPVQTVTSAEE
Sbjct: 781 ERWADILAKVRGKNLPKGTEVPPLIKTTSPPSLSLEVTPPFPAISPPSASPVQTVTSAEE 840
Query: 841 SSADVPLLGEEEHVLGTISSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITS 900
SSADVPLLGEEEHVLGTISSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITS
Sbjct: 841 SSADVPLLGEEEHVLGTISSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITS 900
Query: 901 TEGDLKGTAAPTLISEPYEPSPTLHTLDTVYEKPTHEETATEGWSAADVGSSPEPTSSEY 960
TEGDLKGTAAPTLISEPYEPSPTLHTLDTVYEKPTHEETATEGWSAADVGSSPEPTSSEY
Sbjct: 901 TEGDLKGTAAPTLISEPYEPSPTLHTLDTVYEKPTHEETATEGWSAADVGSSPEPTSSEY 960
Query: 961 EPPLDAVSLAESEPMQYFDPDLETKSQPDEDKMKEDTFAHLTPTPTIWVNDSSTSQLFED 1020
EPPLDAVSLAESEPMQYFDPDLETKSQPDEDKMKEDTFAHLTPTPTIWVNDSSTSQLFED
Sbjct: 961 EPPLDAVSLAESEPMQYFDPDLETKSQPDEDKMKEDTFAHLTPTPTIWVNDSSTSQLFED 1020
Query: 1021 STIGEPGVPGQSHLQGLTDNIHLVKSSLSTQDTLLIKKGMKEMSQTLQGGNMLEGDPTHS 1080
STIGEPGVPGQSHLQGLTDNIHLVKSSLSTQDTLLIKKGMKEMSQTLQGGNMLEGDPTHS
Sbjct: 1021 STIGEPGVPGQSHLQGLTDNIHLVKSSLSTQDTLLIKKGMKEMSQTLQGGNMLEGDPTHS 1080
Query: 1081 RSSESEGQESKSITLPDSTLGIMSSMSPVKKPAETTVGTLLDKDTTTATTTPRQKVAPSS 1140
RSSESEGQESKSITLPDSTLGIMSSMSPVKKPAETTVGTLLDKDTTTATTTPRQKVAPSS
Sbjct: 1081 RSSESEGQESKSITLPDSTLGIMSSMSPVKKPAETTVGTLLDKDTTTATTTPRQKVAPSS 1140
Query: 1141 TMSTHPSRRRPNGRRRLRPNKFRHRHKQTPPTTFAPSETFSTQPTQAPDIKISSQVESSL 1200
TMSTHPSRRRPNGRRRLRPNKFRHRHKQTPPTTFAPSETFSTQPTQAPDIKISSQVESSL
Sbjct: 1141 TMSTHPSRRRPNGRRRLRPNKFRHRHKQTPPTTFAPSETFSTQPTQAPDIKISSQVESSL 1200
Query: 1201 VPTAWVDNTVNTPKQLEMEKNAEPTSKGTPRRKHGKRPNKHRYTPSTVSSRASGSKPSPS 1260
VPTAWVDNTVNTPKQLEMEKNAEPTSKGTPRRKHGKRPNKHRYTPSTVSSRASGSKPSPS
Sbjct: 1201 VPTAWVDNTVNTPKQLEMEKNAEPTSKGTPRRKHGKRPNKHRYTPSTVSSRASGSKPSPS 1260
Query: 1261 PENKHRNIVTPSSETILLPRTVSLKTEGPYDSLDYMTTTRKIYSSYPKVQETLPVTYKPT 1320
PENKHRNIVTPSSETILLPRTVSLKTEGPYDSLDYMTTTRKIYSSYPKVQETLPVTYKPT
Sbjct: 1261 PENKHRNIVTPSSETILLPRTVSLKTEGPYDSLDYMTTTRKIYSSYPKVQETLPVTYKPT 1320
Query: 1321 SDGKEIKDDVATNVDKHKSDILVTGESITNAIPTSRSLVSTMGEFKEESSPVGFPGTPTW 1380
SDGKEIKDDVATNVDKHKSDILVTGESITNAIPTSRSLVSTMGEFKEESSPVGFPGTPTW
Sbjct: 1321 SDGKEIKDDVATNVDKHKSDILVTGESITNAIPTSRSLVSTMGEFKEESSPVGFPGTPTW 1380
Query: 1381 NPSRTAQPGRLQTGIPVTTSGENLTDPPLLKELEDVDFTSEFLSSLTVSTPFHQEEAGSS 1440
NPSRTAQPGRLQTGIPVTTSGENLTDPPLLKELEDVDFTSEFLSSLTVSTPFHQEEAGSS
Sbjct: 1381 NPSRTAQPGRLQTGIPVTTSGENLTDPPLLKELEDVDFTSEFLSSLTVSTPFHQEEAGSS 1440
Query: 1441 TTLSSIKVEVASSQAETTTLDQDHLETTVAILLSETRPQNHTPTAARMKEPASSSPSTIL 1500
TTLSSIKVEVASSQAETTTLDQDHLETTVAILLSETRPQNHTPTAARMKEPASSSPSTIL
Sbjct: 1441 TTLSSIKVEVASSQAETTTLDQDHLETTVAILLSETRPQNHTPTAARMKEPASSSPSTIL 1500
Query: 1501 MSLGQTTTTKPALPSPRISQASRDSKENVFLNYVGNPETEATPVNNEGTQHMSGPNELST 1560
MSLGQTTTTKPALPSPRISQASRDSKENVFLNYVGNPETEATPVNNEGTQHMSGPNELST
Sbjct: 1501 MSLGQTTTTKPALPSPRISQASRDSKENVFLNYVGNPETEATPVNNEGTQHMSGPNELST 1560
Query: 1561 PSSDQDAFNLSTKLELEKQVFGSRSLPRGPDSQRQDGRVHASHQLTRVPAKPILPTATVR 1620
PSSDQDAFNLSTKLELEKQVFGSRSLPRGPDSQRQDGRVHASHQLTRVPAKPILPTATVR
Sbjct: 1561 PSSDQDAFNLSTKLELEKQVFGSRSLPRGPDSQRQDGRVHASHQLTRVPAKPILPTATVR 1620
Query: 1621 LPEMSTQSASRYFVTSQSPRHWTNKPEITTYPSGALPENKQFTTPRLSSTTIPLPLHMSK 1680
LPEMSTQSASRYFVTSQSPRHWTNKPEITTYPSGALPENKQFTTPRLSSTTIPLPLHMSK
Sbjct: 1621 LPEMSTQSASRYFVTSQSPRHWTNKPEITTYPSGALPENKQFTTPRLSSTTIPLPLHMSK 1680
Query: 1681 PSIPSKFTDRRTDQFNGYSKVFGNNNIPEARNPVGKPPSPRIPHYSNGRLPFFTNKTLSF 1740
PSIPSKFTDRRTDQFNGYSKVFGNNNIPEARNPVGKPPSPRIPHYSNGRLPFFTNKTLSF
Sbjct: 1681 PSIPSKFTDRRTDQFNGYSKVFGNNNIPEARNPVGKPPSPRIPHYSNGRLPFFTNKTLSF 1740
Query: 1741 PQLGVTRRPQIPTSPAPVMRERKVIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPS 1800
PQLGVTRRPQIPTSPAPVMRERKVIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPS
Sbjct: 1741 PQLGVTRRPQIPTSPAPVMRERKVIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPS 1800
Query: 1801 TNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSP 1860
TNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSP
Sbjct: 1801 TNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSP 1860
Query: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQV 1920
QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQV
Sbjct: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQV 1920
Query: 1921 QDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAP 1980
QDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAP
Sbjct: 1921 QDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAP 1980
Query: 1981 QISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL 2040
QISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL
Sbjct: 1981 QISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL 2040
Query: 2041 HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF 2100
HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF
Sbjct: 2041 HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF 2100
Query: 2101 VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRY 2160
VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRY
Sbjct: 2101 VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRY 2160
Query: 2161 GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYL 2220
GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYL
Sbjct: 2161 GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYL 2220
Query: 2221 CVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLP 2280
CVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLP
Sbjct: 2221 CVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLP 2280
Query: 2281 DGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVK 2340
DGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVK
Sbjct: 2281 DGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVK 2340
Query: 2341 VVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD 2400
VVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD
Sbjct: 2341 VVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD 2400
Query: 2401 GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGS 2460
GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGS
Sbjct: 2401 GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGS 2460
Query: 2461 RKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMA 2520
RKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMA
Sbjct: 2461 RKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMA 2520
Query: 2521 RNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPN 2580
RNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPN
Sbjct: 2521 RNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPN 2580
Query: 2581 GTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEAN 2640
GTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEAN
Sbjct: 2581 GTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEAN 2640
Query: 2641 KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVRE 2700
KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVRE
Sbjct: 2641 KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVRE 2700
Query: 2701 ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGI 2760
ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGI
Sbjct: 2701 ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGI 2760
Query: 2761 PKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDS 2820
PKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDS
Sbjct: 2761 PKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDS 2820
Query: 2821 KTTYIHVF 2828
KTTYIHVF
Sbjct: 2821 KTTYIHVF 2828
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 940 bits (2430), Expect = 0.0
Identities = 577/1627 (35%), Positives = 858/1627 (52%), Gaps = 112/1627 (6%)
Query: 1240 KHRYTPSTVSSRASGSKPSPSPENKHRNIVTPSSETILLPRTVSLKTEGPYDSLDYMTTT 1299
+ R T +T + + P P+ + PS E+ L + L E S++ T T
Sbjct: 1069 RERLTTATAALSFPSAAPITFPKADIARV--PSEESTTLVQNPLLLLENK-PSVEKTTPT 1125
Query: 1300 RKIYSSYPKVQETLP----VTYKPTSDGKEIKDDV------ATNVDKHKSDILVTGESIT 1349
K + + ++ + P +TY PTS E V ++ ++ K D ++T S++
Sbjct: 1126 IKYFRT--EISQVTPTGAVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITS-SLS 1182
Query: 1350 NAIPTSRSLVSTMGEFKEESSPVGFPGTPTWNPSRTAQPGRLQTGIPVTTSGENLTDPPL 1409
AI + + F P NP GRL+ V+ P
Sbjct: 1183 GAITKPPMTIIAITRFSRRKIPWQQNFVNNHNPK-----GRLRNQHKVSLQKSTAVMLPK 1237
Query: 1410 LKELEDVDFTSEFLSSLTVSTPFHQEEAGSSTTLSSIKVEVASSQAETTTLDQDHLETTV 1469
TS L VS PFH TTLS+ +++ S+ TL H TT
Sbjct: 1238 ---------TSPALPRDKVS-PFH------FTTLSTSVMQIPSN-----TLTTAHHTTT- 1275
Query: 1470 AILLSETRPQNHTPTAARMKEPA-----------SSSPSTILMSLGQTTTTKPALPSPRI 1518
+T PT + P SS +I+ + T P P+ I
Sbjct: 1276 -----KTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPATTPTFPASVI 1330
Query: 1519 SQASRDSKENVFLNYVGNPETEATPVNNEGTQHMSGPNELS---TPSSDQDAFNLSTKLE 1575
+ ++ + + E P T P++ S TP++ + +
Sbjct: 1331 TYETQTERSRA-----QTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLTTAETS 1385
Query: 1576 LEKQVFGSRSLPRGPDSQRQDGRVHASHQLTRVPAKPILPTATVRLPEMSTQSASRYFVT 1635
++ V P P++ + H T I A + + AS ++
Sbjct: 1386 VKPSVSAFTHSP--PENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASETTLS 1443
Query: 1636 SQSPRHWTNKPEITTYPSGALPENKQFTTPRLSSTTIPLPLHMSKPSIPSKFTDRRTDQF 1695
S+S + T + I + + P LSS+ +P+ +S P TD
Sbjct: 1444 SKSHQSTTTRKAIIRHST---------IPPFLSSSATLMPVPISPPFTQRAVTDNVATPI 1494
Query: 1696 NGYSKVFGNN--NIPEARNPVGKPP--------SPRIPHYSNGRLPFFTNKTLSFPQLGV 1745
+G + N + E+ KP SP++ + N + FT T F +
Sbjct: 1495 SG---LMTNTVVKLHESSRHNAKPQQLVAEVATSPKV--HPNAK---FTIGTTHFIYSNL 1546
Query: 1746 TRRPQIPTSPAPVMRERKVIPGSYNRIHSHSTFHLDFGPPAP----PLLHTPQTTG-SPS 1800
+P + K+ P + + +H + A P + TTG S +
Sbjct: 1547 LHSTPMPALTTVKSQNSKLTPSPWAE---NQFWHKPYSEIAEKGKKPEVSMLATTGLSEA 1603
Query: 1801 TNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSP 1860
T L + F VQ + ++SK P S + EKP+I+
Sbjct: 1604 TTLVSDWDGQKNTKKSDFDKKPVQEA-----TTSKLL---PFDSLSRYIFEKPRIVGGKA 1655
Query: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQV 1920
+ ++ A +D PCEA G P P + WT+V +G ++ + R +VL NGTL I++V++
Sbjct: 1656 ASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEI 1715
Query: 1921 QDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAP 1980
QDRGQY+C+ASNL G D + V LSV P+IL +++TV+ G T+ ++C A+G P+P
Sbjct: 1716 QDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSP 1775
Query: 1981 QISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL 2040
++WI ++ V S + + + TL + S DRG YKCVASN G DSL +++
Sbjct: 1776 TVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKI 1835
Query: 2041 HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF 2100
V A PPVI +++ + I G S+ + CTAK P PSV WVL DGT+++P QF + LF
Sbjct: 1836 QVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLF 1895
Query: 2101 VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRY 2160
+F NGTLYIRNLA D G YEC+A + GS RR V L ++ + RI S +RT+V +
Sbjct: 1896 LFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNF 1955
Query: 2161 GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYL 2220
G L L+CSA+G+P P+I+WRLPSK ++D S I V+ NG+L + SVT+KD+G YL
Sbjct: 1956 GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYL 2015
Query: 2221 CVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLP 2280
CVARNK+GDD +++ V + +KPAKI+HK+ +V +G D +VDC A+G P PEISWSLP
Sbjct: 2016 CVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLP 2075
Query: 2281 DGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVK 2340
DG+++N+ MQ+DDSG RT+RY +FNNGTLYFN+VG+ EEGDYTC+A+N +GKDEM+V +
Sbjct: 2076 DGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLT 2135
Query: 2341 VVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD 2400
V+TA IR ++ GD + CE G+P PK+ WL P+N +I S ++Y + +
Sbjct: 2136 VITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHAN 2195
Query: 2401 GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGS 2460
G+L I K + DSG Y C+ RN +G+D K + V +PP ING T ++ A S
Sbjct: 2196 GSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHS 2255
Query: 2461 RKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMA 2520
+K DC+AEG P+P V+W P+ + L APYYG+RITVH NG+L+IR++R SDS +C+A
Sbjct: 2256 KKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVA 2315
Query: 2521 RNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPN 2580
RNEGGE+ L++QL VLE + +P F +P +EKI A G + +LNCS G P P ++W+LPN
Sbjct: 2316 RNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPN 2375
Query: 2581 GTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEAN 2640
GT +G Q ++ ++G IS + DAG YRC ARN G+ E+LV L++G KP
Sbjct: 2376 GTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVIL 2435
Query: 2641 KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVRE 2700
V I+GE+L L C G + WT+P+G ++ PQ G+ L DNGTL ++E
Sbjct: 2436 TYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKE 2495
Query: 2701 ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGI 2760
A+ +DRG Y+C+ + G ++ ++PV+++AYPPRIT+ P I TR G +L+C+A+G+
Sbjct: 2496 ATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGV 2555
Query: 2761 PKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDS 2820
PK +ITWE+PD S L + R +G+ LH QG+L IQ+ D+G YKC AKN LGSD
Sbjct: 2556 PKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDY 2615
Query: 2821 KTTYIHV 2827
TYI V
Sbjct: 2616 AATYIQV 2622
Score = 861 bits (2225), Expect = 0.0
Identities = 747/2739 (27%), Positives = 1183/2739 (43%), Gaps = 295/2739 (10%)
Query: 26 ACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERINLGFNSIQALSETSFAGLTKLELLM 85
ACP CACY+P+EVHCTFR L S+P I +VERINLG+NS+ L ET F+GLTKLELLM
Sbjct: 28 ACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLM 87
Query: 86 IHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQGLSNLMRLHIDHNKIEFIHPQ 145
+H N I +IPD DL +LQV K SYNK+R + T GL +L RLH+DHN IEFI+P+
Sbjct: 88 LHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPE 147
Query: 146 AFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLSTIRHLYLAENMVRTLPASMLRN 205
F GL LRL+HLEGN L +LHP TF + ++L F++S I+ LYL++N + +LP M+
Sbjct: 148 VFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSY 207
Query: 206 MPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILKCKKDKAYEGGQLCAMCFSPKKLYKH 265
MP L++LYL GNPWTCDC ++W +W + ++KCKKD++ Q C +C +P+
Sbjct: 208 MPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGK 267
Query: 266 EIHKLK--DMTCLKPSIESPLRQNRSRSIEEEQEQEEDGGSQLILEKFQLPQWSISLNMT 323
+ + C KP+I+S L+ ++S +I E+ + + + F P S++LNMT
Sbjct: 268 PLAMVSAAAFQCAKPTIDSSLK-SKSLTI-----LEDSSSAFISPQGFMAPFGSLTLNMT 321
Query: 324 DEHGNMVNLVCDIKKPMDVYKIHLNQTDPPDIDINATVALDFECPMTRENYEKLWKLIAY 383
D+ GN N+VC I+KP I + + I +N + + C + + + +W+++A
Sbjct: 322 DQSGNEANMVCSIQKPSRTSPIAFTE-ENDYIVLNTSFSTFLVCNIDYGHIQPVWQILAL 380
Query: 384 YSEVPVKLHRELMLSKDPRVSYQYRQDADEEALYYTGVRAQILAEPEWVMQPSIDIQLNR 443
YS+ P+ L R +LS+ P++ Y+Y+Q A + +T + A + A+P W+MQ I +QLNR
Sbjct: 381 YSDSPLILERSHLLSETPQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNR 440
Query: 444 RQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNV 503
+T + + Y + T+ + R + W MI + + TVL GG L+C
Sbjct: 441 TATTFSTLQIQYSSDAQITLPRAEMRPVK-HKWTMISRDNNTKLEHTVLVGGTVGLNCPG 499
Query: 504 KASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEM 563
+ +P + W+L DGS ++AP D + I SG L ++ + D+G+Y CI+ D+
Sbjct: 500 QGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDA 559
Query: 564 DRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLA 623
D + YR+ V P + +++ + GE++ LPC++ IP+A +SW++P ++ +
Sbjct: 560 DILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSS 619
Query: 624 NTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRP 683
V L NGTL I +V D GYYRCVA N G D ++V K G+RP
Sbjct: 620 RDKKV--LNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMK--------GQRP 669
Query: 684 GAKALSRVREDIVEDEG---GSGMGDEENTSRRLLHPKDQEVFLKTKDDAINGDKKAKKG 740
+E +G GSG+ DE N L P ++ +A G +
Sbjct: 670 ------------LEHDGETEGSGL-DESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTS 716
Query: 741 RRKLKLWKHSEKE---PETNVAEGRRVFESRRRINMANKQINPERWADILAKVRGKNLPK 797
+R H+ +E + RR E+RR + ++I+P+ WA +L K + +P
Sbjct: 717 KR------HNYRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMPD 770
Query: 798 GTEVPPLIKTTSPPSLSLEVTPPFPAISPPSASPVQTVTSAEESSADVPLLGEEEHVLGT 857
E TT P PP + + + E+ S+ + L EE V T
Sbjct: 771 KRE-----NTTVSP--------------PPVVTQLPNIPGEEDDSSGMLALHEEFMVPAT 811
Query: 858 ISSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITSTEGDLKGTAAPTLISEP 917
+ + P V D S + T + +P + S+
Sbjct: 812 --------------------KALNLPARTVTAD-SRTISDSPMTNINYGTEFSPVVNSQI 850
Query: 918 YEP-SPTLHTLDTVYEKPTHEETATEGWSAADVGSSPEPTSSEYEPPLDAVSLAESEPM- 975
P PT L T + + S+ G++ + +S+ + L A +S+ M
Sbjct: 851 LPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMG 910
Query: 976 ---QYFD--PDLETKSQPDEDKMKEDTFAHLTPTPTIWVNDSSTSQLFEDSTIGEPGVPG 1030
++F P + ++ +K+ L+ T + +S + +++ E P
Sbjct: 911 RGREHFQSRPPITVRTM-----IKDVNVKMLSSTTNKLLLESVNTTNSHQTSVREVSEPR 965
Query: 1031 QSHLQGLTDNI----------HLVKSS---LSTQDTLLIKKGMKEMSQTLQGGNMLEGDP 1077
+H T I H S + T+ I + Q GG P
Sbjct: 966 HNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRRFGRQRKIGGRGRIISP 1025
Query: 1078 -------THSRS---SESEGQESKSITLPDSTLGIMSSMSPVKKPAETTVGTLLDKDTTT 1127
H S S + G KS T +T+ ++ +S + + TT L +
Sbjct: 1026 YRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATAALSFPSAA 1085
Query: 1128 ATTTPRQKVA-----PSSTMSTHP---SRRRPNGRRRLRPNK-FRHRHKQTPPT----TF 1174
T P+ +A S+T+ +P +P+ + K FR Q PT T+
Sbjct: 1086 PITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY 1145
Query: 1175 APS----ETFSTQPTQAPDIKISSQVESSLVPTAWVDNTVNTP------------KQLEM 1218
AP+ E P + +++ + V T+ + + P +++
Sbjct: 1146 APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPW 1205
Query: 1219 EKN--AEPTSKGTPRRKHGKRPNKHRYTPSTVSSRASGSKPSPSPENKHRNIVTPS---- 1272
++N KG R +H K + + + + S + P H ++ S
Sbjct: 1206 QQNFVNNHNPKGRLRNQHKVSLQK---STAVMLPKTSPALPRDKVSPFHFTTLSTSVMQI 1262
Query: 1273 -SETILLPRTVSLKTEGPYDSLDYMTTTRKIYSSYPKVQETLPVTYKPTSDGKEIKDDVA 1331
S T+ + KT P + T +++ +P + LP S K I ++
Sbjct: 1263 PSNTLTTAHHTTTKTHNP----GSLPTKKEL--PFPPLNPMLPSIISKDSSTKSI---IS 1313
Query: 1332 TNVDKHKSDILVTGESITNAIPTSRSLVSTMGEFKEESSPVGFPGT-PTWNPSRTAQPGR 1390
T + IT T RS T+ + E P T P +P ++
Sbjct: 1314 TQTAIPATTPTFPASVITYETQTERSRAQTI---QREQEPQKKNRTDPNISPDQS----- 1365
Query: 1391 LQTGIPVTTSGENLTDPPLLKELEDVDFTSEFLSSLTVSTPFHQEEAGSSTTLSSIKVEV 1450
+G T+ PP+L E +S+ T S P + S+ + S + +
Sbjct: 1366 --SGFTTPTA----MTPPVLTTAE--TSVKPSVSAFTHSPPENTTGISSTISFHSRTLNL 1417
Query: 1451 ASSQAETTTLDQDHLETTVAILLSET--RPQNHTPTAARMKEPASSSPSTILMSLGQTTT 1508
E L++T+A SET ++H T R A STI L + T
Sbjct: 1418 TDVIEELAQASTQTLKSTIA---SETTLSSKSHQSTTTR---KAIIRHSTIPPFLSSSAT 1471
Query: 1509 TKPALPSPRISQASRDSKENVFLNYVGNPETEATPVNNEGTQHMSGPNEL-----STPSS 1563
P SP +Q R +NV + T +E ++H + P +L ++P
Sbjct: 1472 LMPVPISPPFTQ--RAVTDNV-ATPISGLMTNTVVKLHESSRHNAKPQQLVAEVATSPKV 1528
Query: 1564 DQDA-FNLSTKLELEKQVFGSRSLPRGPDSQRQDGRV----HASHQLTRVPAKPILPTAT 1618
+A F + T + + S +P + Q+ ++ A +Q P I
Sbjct: 1529 HPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAENQFWHKPYSEIAEKG- 1587
Query: 1619 VRLPEMSTQSASRYFVTSQSPRHWTNKPEITTYPSGALPENKQFTTPRLSSTTIPLPLHM 1678
+ PE+S + + + W + P + T+ L ++ +
Sbjct: 1588 -KKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLSRYI-F 1645
Query: 1679 SKPSI----PSKFT-DRRTDQFNGYSKVFGNNNIPE---ARNPVGKPPSPRIPHYSNGRL 1730
KP I + FT +D F V N +P R P G S R N R+
Sbjct: 1646 EKPRIVGGKAASFTIPANSDAFLPCEAV--GNPLPTIHWTRVPSGLDLSKR---KQNSRV 1700
Query: 1731 PFFTNKTLSFPQLGVTRRPQIPTSPA------------------PVMRERKVIPGSYNRI 1772
N TLS ++ + R Q S + P + ER+ +
Sbjct: 1701 QVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRT---KEITV 1757
Query: 1773 HSHSTFHLDF---GPPAPPL--LHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSG 1827
HS ST L G P+P + + QT S S+ +V + ++ S+ G
Sbjct: 1758 HSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVV-TVDGTLVLHNLSIYDRG 1816
Query: 1828 SFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTW 1887
+ +S K + P IL + Q + T PC A G P+P V W
Sbjct: 1817 FYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYW 1876
Query: 1888 TKVSTGALMTP----NTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLL 1943
+S G + P N+++ F NGTL IR + DRG Y C A++ G +R VV+L
Sbjct: 1877 V-LSDGTEVKPLQFTNSKLFLF---SNGTLYIRNLASSDRGTYECIATSSTGSERRVVML 1932
Query: 1944 SV--TVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGR 2001
++ V P+I A+ + V GD + + C A G P PQI W P + V V
Sbjct: 1933 TMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSW 1992
Query: 2002 ITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPP 2061
I ++ N +L I + D GVY CVA N G D + + + + P I ++ +
Sbjct: 1993 IHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH 2052
Query: 2062 GLSIHIHCTAKAAPLPSVRWVLGDGTQIR------PSQFLHGNLFVFPNGTLYIRNLAPK 2115
G + C A +P+P + W L DGT I S +F NGTLY +
Sbjct: 2053 GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVA 2112
Query: 2116 DSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPW 2175
+ G Y C A N +G V L V AA R + + +R ++ G T LDC +GDP
Sbjct: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKR--IKAGDTAVLDCEVTGDPK 2170
Query: 2176 PRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLK 2235
P+I W LPS MI FS D R ANG+L + V D+G+Y+CVARN GDD + K
Sbjct: 2171 PKIFWLLPSNDMIS--FSID-RYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYK 2227
Query: 2236 VDVVMKPAKIEHKEENDHKV----FYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQS 2291
+DVV KP I N + DC A G P+PE+ W +PD N F+ +
Sbjct: 2228 LDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPD----NIFLTA 2283
Query: 2292 DDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKV--VTAPATIR 2349
G R V NGTL V + + D+ C A N+ G+ + V+++V + T R
Sbjct: 2284 PYYG---SRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFR 2340
Query: 2350 NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQ--IYQDGTLLIQK 2407
N + G + C G P P++ W+ P + YQ I +G+ +I K
Sbjct: 2341 NPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISK 2400
Query: 2408 AQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCK 2467
R D+G Y C RN G K V + + +P + P TV+ I+ G + C
Sbjct: 2401 TTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPG---TVKGIS--GESLSLHCV 2455
Query: 2468 AEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEA 2527
++GIP P + W P G V+ P + +H NG+L I+ D +C A+N G
Sbjct: 2456 SDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHT 2515
Query: 2528 RLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSG 2587
+ + + ++ + P S I G L+C A G P P + W +P+ + L +
Sbjct: 2516 LITVPVMIVAYPPRITNRPPRS--IVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTA 2573
Query: 2588 QQLQRFYHK---ADGMLHISGLSSVDAGAYRCVARNAAG 2623
+ + + G L I + D+G Y+C A+N G
Sbjct: 2574 SKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
Score = 393 bits (1009), Expect = e-108
Identities = 263/969 (27%), Positives = 437/969 (45%), Gaps = 41/969 (4%)
Query: 1783 GPPAPPLLHTPQTTGSP-STNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGP 1841
G P P + T +G S QN + ++S +Q G + S+S F
Sbjct: 1674 GNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDH 1733
Query: 1842 PASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTR 1901
+ P+IL + + ++V + + C A G+P P VTW + + +
Sbjct: 1734 LHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQG 1793
Query: 1902 IQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVT 1961
++ V +GTLV+ + + DRG Y C ASN G D ++V + V P IL Q +
Sbjct: 1794 SRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIV 1853
Query: 1962 VYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRG 2021
G+++ + C AKGTP P + W+ D + + ++ L N TL I+ + SDRG
Sbjct: 1854 GTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRG 1913
Query: 2022 VYKCVASNAAGADSLAIRLHVA--ALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
Y+C+A+++ G++ + L + P I + + G + ++C+A P P +
Sbjct: 1914 TYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQI 1973
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
W L + + + V+PNG+L+I ++ KDSG Y CVA N +G + ++V
Sbjct: 1974 MWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDD--LILMHV 2031
Query: 2140 QRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDS--- 2196
A+I R V +G ++DC ASG P P I W LP MI+ D
Sbjct: 2032 SLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGH 2091
Query: 2197 ---RIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDH 2253
R +F NGTL V + GDY C A+N +G D + + + V+ +I + +
Sbjct: 2092 RTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNK 2151
Query: 2254 KVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNE 2313
++ G +DC TG P P+I W LP +++ + RY NG+L N+
Sbjct: 2152 RIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSID---------RYTFHANGSLTINK 2202
Query: 2314 VGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIR----NKTYLAVQVPYGDVVTVACE 2369
V + + G+Y C A N G D ++ VV+ P I N+T + C
Sbjct: 2203 VKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCR 2262
Query: 2370 AKGEPMPKVTWLSPTNKVI--PTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGED 2427
A+G P P+V W+ P N + P + ++++GTL I+ + SDS ++ C+ RN GE
Sbjct: 2263 AEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGES 2322
Query: 2428 RKTVWIHV--NVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVV 2485
V + V ++ P NP + +A G ++C +G P P ++W P G
Sbjct: 2323 VLVVQLEVLEMLRRPTFR---NPFNE-KIVAQLGKSTALNCSVDGNPPPEIIWILPNGTR 2378
Query: 2486 LPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH 2545
+ + NGS I + D+ + C ARN+ G I +L +LE +KP+
Sbjct: 2379 FSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVG---YIEKLVILEIGQKPVIL 2435
Query: 2546 DPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISG 2605
+ ++G ++SL+C + G P P++ W +P+G + Q ++ +G L I
Sbjct: 2436 TYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKE 2495
Query: 2606 LSSVDAGAYRCVARNAAGHTERLVSLKVGLKPE--ANKQYHNLVSIINGETLKLPCTPPG 2663
++ D G Y C A+N+ GHT V + + P N+ ++V+ G +L C G
Sbjct: 2496 ATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTR-TGAAFQLHCVALG 2554
Query: 2664 AGQGRFSWTLPNGMHLEGP---QTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPS 2720
+ +W +P+ L +T G L GTL ++ D G Y C + G
Sbjct: 2555 VPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
Query: 2721 VTSIPVIVI 2729
+ + VI
Sbjct: 2615 YAATYIQVI 2623
Score = 80.5 bits (197), Expect = 2e-14
Identities = 50/175 (28%), Positives = 84/175 (48%), Gaps = 6/175 (3%)
Query: 2464 IDCKAEGIPTPRVLWAFPEGVVLPAPYYGN--RITVHGNGSLDIRSLRKSDSVQLVCMAR 2521
++C +G PTP V W +G + APY RI + +G L+++ D+ C++
Sbjct: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISS 554
Query: 2522 NEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNG 2581
N L ++TV+EP+ + + I T G T+ L C + G P S+ WV+P
Sbjct: 555 NYDDADILTYRITVVEPLVEAYQENGIHH--TVFIGETLDLPCHSTGIPDASISWVIPGN 612
Query: 2582 TDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLK 2636
L + ++ + +G L I ++ D G YRCVA N +G + + V +K
Sbjct: 613 NVLYQSSRDKKVLN--NGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMK 665
Score = 75.1 bits (183), Expect = 9e-13
Identities = 50/164 (30%), Positives = 77/164 (46%), Gaps = 9/164 (5%)
Query: 2553 TAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQ--RFYHKADGMLHISGLSSVD 2610
T + G T+ LNC G PTP + W+L +G+ +++ + R G L + S D
Sbjct: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
Query: 2611 AGAYRCVARN---AAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQG 2667
G Y C++ N A T R+ ++ ++ H+ V I GETL LPC G
Sbjct: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI--GETLDLPCHSTGIPDA 603
Query: 2668 RFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVC 2711
SW +P L Q+ +L+NGTL + + + D+G Y C
Sbjct: 604 SISWVIPGNNVLY--QSSRDKKVLNNGTLRILQVTPKDQGYYRC 645
Score = 68.9 bits (167), Expect = 7e-11
Identities = 47/180 (26%), Positives = 78/180 (43%), Gaps = 5/180 (2%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSG 551
+ G L C P+I W +P G ++ P + K+ + +G L IK D G
Sbjct: 2445 ISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQIN--GKYILHDNGTLVIKEATAYDRG 2502
Query: 552 LYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSW 611
Y C AQ + V++ + + + +I G + L C AL +P+ ++W
Sbjct: 2503 NYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITW 2562
Query: 612 ILPNRRIINDLANT---SHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
+P+ +++ + + GTL I Q SDSG Y+C A N G+D+ I V
Sbjct: 2563 EMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
Score = 65.1 bits (157), Expect = 9e-10
Identities = 49/180 (27%), Positives = 79/180 (43%), Gaps = 19/180 (10%)
Query: 2648 SIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTL--GRVSLLDNGTLTVREASVFD 2705
+++ G T+ L C G W L +G + P GR+ + +G L ++ A FD
Sbjct: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
Query: 2706 RGTYVCRMETEYGPS------VTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMG 2759
G Y C + + Y + +T + +V AY + G T+ L C + G
Sbjct: 546 TGVYHC-ISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI-----GETLDLPCHSTG 599
Query: 2760 IPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSD 2819
IP A I+W +P + L + + N G+L I T +D G+Y+C+A N G D
Sbjct: 600 IPDASISWVIPGNNVLYQSSRDKKVLNN-----GTLRILQVTPKDQGYYRCVAANPSGVD 654
Score = 43.1 bits (100), Expect = 0.004
Identities = 27/80 (33%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 2748 GNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGF 2807
G TV LNC G P + W L D S ++A + G + G L +Q A D G
Sbjct: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSE-DGRILIDKSGKLELQMADSFDTGV 548
Query: 2808 YKCMAKNILGSDSKTTYIHV 2827
Y C++ N +D T I V
Sbjct: 549 YHCISSNYDDADILTYRITV 568
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 328 bits (842), Expect = 4e-89
Identities = 289/1036 (27%), Positives = 450/1036 (43%), Gaps = 81/1036 (7%)
Query: 1812 TQSSISFITSSVQ--SSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAET 1869
T +++S SV+ +G +H S G AS F ++ E P++ T P+ S T +
Sbjct: 570 TLANLSLELKSVKFNDAGEYHCMVSSE-GGSSAASVFLTVQEPPKV-TVMPKNQSFTGGS 627
Query: 1870 DTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCT 1929
+ C ATG PKP + WT + + R+ + +GTL I+ +D G Y C
Sbjct: 628 EVSIMCSATGYPKPKIAWTVNDMFIVGS-----HRYRMTSDGTLFIKNAAPKDAGIYGCL 682
Query: 1930 ASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDR 1989
ASN G D+ L ++ P+++ ++ V LGD MEC G P PQ+ W D
Sbjct: 683 ASNSAGTDKQNSTLRY-IEAPKLMVVQ-SELLVALGDITVMECKTSGIPPPQVKWFKGDL 740
Query: 1990 RV----WQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAAL 2045
+ + + P+ G + + E + L D G Y CVA N AG + I L V +
Sbjct: 741 ELRPSTFLIIDPLLGLLKIQETQDL--------DAGDYTCVAINEAGRATGKITLDVGS- 791
Query: 2046 PPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNG 2105
PPV QE + +S+ G ++ + C + P P+++W D I F ++ G
Sbjct: 792 PPVFIQEPAD-VSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTG 850
Query: 2106 TLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLK 2165
L+I NL D G Y C A N G + + V A + G SP +V G L
Sbjct: 851 ALFILNLWASDKGTYICEAENQFGKIQSETTVTV--TGLVAPLIGISPSVANVIEGQQLT 908
Query: 2166 LDCS-ASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVAR 2224
L C+ +G+P P W S ++ + I V ++G+L ++ V +D G+Y CVA
Sbjct: 909 LPCTLLAGNPIPERRWIKNSAMLLQ-----NPYITVRSDGSLHIERVQLQDGGEYTCVAS 963
Query: 2225 NKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSL 2284
N G + V V + P I+H ++ G + + C A+G P P + WS G L
Sbjct: 964 NVAGTNNKTTSVVVHVLPT-IQHGQQ-ILSTIEGIPVTLPCKASGNPKPSVIWS-KKGEL 1020
Query: 2285 VNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTA 2344
+++ +G +G+LY G E G+Y C A N G + +V++ V
Sbjct: 1021 ISTSSAKFSAGA---------DGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVR 1071
Query: 2345 PATIRNKTYLA------VQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIY 2398
P ++ L+ + V G+ VT+ CE K P P +TW T + P S ++
Sbjct: 1072 PRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISP-FSPRHTFL 1130
Query: 2399 QDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAG 2458
G++ I + + SDSG Y C+ N AG + V ++V+V PPKI P +
Sbjct: 1131 PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV-PPKIQRGPKHLK-----VQV 1184
Query: 2459 GSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVC 2518
G R I C A+G P P + W+ +L G + +G+L I SD+ C
Sbjct: 1185 GQRVDIPCNAQGTPLPVITWSKGGSTML---VDGEHHVSNPDGTLSIDQATPSDAGIYTC 1241
Query: 2519 MARNEGGEARLILQLTVLEPME----KPIFHDPISEKITAMAGHTISLNCSAAGTPTPSL 2574
+A N G + L V EP +P ++ E++ A I C A GTP P++
Sbjct: 1242 VATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERV---ANQRIEFPCPAKGTPKPTI 1298
Query: 2575 VWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVG 2634
W L NG +L +G++ + +L I+ ++ D G Y CVA N AG TER +LKV
Sbjct: 1299 KW-LHNGREL-TGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVH 1356
Query: 2635 LKPE-ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN 2693
+ P +K+ VS++ + L C G W N E + ++N
Sbjct: 1357 VPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTES----STIQTVNN 1412
Query: 2694 G-TLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVK 2752
G L + A+ D G Y C+ G S + V+ P I + + V
Sbjct: 1413 GKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVA 1472
Query: 2753 LNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMA 2812
L C G P DI W K L L L +++A + D G Y+C
Sbjct: 1473 LECQVKGTPFPDIHWFKDGKPLFLGDPNVEL-----LDRGQVLHLKNARRNDKGRYQCTV 1527
Query: 2813 KNILGSDSKTTYIHVF 2828
N G +K + ++
Sbjct: 1528 SNAAGKQAKDIKLTIY 1543
Score = 316 bits (810), Expect = 2e-85
Identities = 260/879 (29%), Positives = 394/879 (44%), Gaps = 67/879 (7%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P + PQ++ + TV C A G P P +TW K GA++ N R+ +L+NG
Sbjct: 3712 PPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRK--DGAVLAGNHA--RYSILENGF 3767
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMEC 1972
L I+ V D G+Y+C A+N G DR + L V V P +A ++TV + + C
Sbjct: 3768 LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHV--PPSIAPGPTNMTVIVNVQTTLAC 3825
Query: 1973 LAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAG 2032
A G P P I+W + V + L + +L I S D Y+C +N AG
Sbjct: 3826 EATGIPKPSINWRKNGHLL--NVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAG 3883
Query: 2033 ADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPS 2092
D + L V +PP I E + + ++ I CTA P PS+ W +G ++ P
Sbjct: 3884 DDKRTVDLTVQ-VPPSIADEPTDFLVTKHAPAV-ITCTASGVPFPSIHWTK-NGIRLLP- 3939
Query: 2093 QFLHGNLF-VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGT 2151
G+ + + +G + I +GRY CVA N GSA R V L+V +
Sbjct: 3940 ---RGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPP----VIQP 3992
Query: 2152 SPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSV 2211
P V + L C A+G P P I W+ K I+ S + V +G L +
Sbjct: 3993 QPSELHVILNNPILLPCEATGTPSPFITWQ---KEGINVNTSGRNHA-VLPSGGLQISRA 4048
Query: 2212 TDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLP 2271
+DAG Y+CVA+N G +K++V + P H +E + + + + C A GLP
Sbjct: 4049 VREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKE--YVIAVDKPITLSCEADGLP 4106
Query: 2272 NPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG 2331
P+I+W ++V S Q V ++G+L V + G YTC A N G
Sbjct: 4107 PPDITWHKDGRAIVESIRQR-----------VLSSGSLQIAFVQPGDAGHYTCMAANVAG 4155
Query: 2332 KDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTS 2391
++ V P + + V + C A G P P + W N ++
Sbjct: 4156 SSSTSTKLTVHVPPRIRSTEGHYTVNE--NSQAILPCVADGIPTPAINW-KKDNVLLANL 4212
Query: 2392 SEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITT 2451
KY G L+++ DSG YTC+ N+AGED TV + V+V P P ++
Sbjct: 4213 LGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVL-PTFTELPGDVSL 4271
Query: 2452 VREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKS 2511
+ G + + CKA GIP P++ W F ++ PA + +V+G+ L I + K
Sbjct: 4272 NK-----GEQLRLSCKATGIPLPKLTWTFNNNII-PAHF----DSVNGHSELVIERVSKE 4321
Query: 2512 DSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH-DPISEKITAMAGHTISLNCSAAGTP 2570
DS VC A N G + I + V EP P+F D S I + G+ I LNC G P
Sbjct: 4322 DSGTYVCTAENSVGFVKAIGFVYVKEP---PVFKGDYPSNWIEPLGGNAI-LNCEVKGDP 4377
Query: 2571 TPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVS 2630
TP++ W G D++ ++++ +G L I G + DAG Y CVA N AG ER +S
Sbjct: 4378 TPTIQW-NRKGVDIEISHRIRQL---GNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMS 4433
Query: 2631 LKVGLKPEANKQYHNLVSIIN-GETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVS 2689
L + P + + ++IN G + L C G Q +W+ G + RV+
Sbjct: 4434 LTLQSPPIITLE--PVETVINAGGKIILNCQATGEPQPTITWS-RQGHSISWDD---RVN 4487
Query: 2690 LLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIV 2728
+L N +L + +A D + C G + +PVIV
Sbjct: 4488 VLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 314 bits (804), Expect = 9e-85
Identities = 268/975 (27%), Positives = 411/975 (42%), Gaps = 68/975 (6%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P I + + T C+ATG P P + W K N+ +L G+
Sbjct: 3151 PSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLK---NHKRIENSDSLEVRILSGGS 3207
Query: 1913 -LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAME 1971
L I + Q D G Y C ASN+ G + LS+ V A DV+V LG+ + +
Sbjct: 3208 KLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELV 3267
Query: 1972 CLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHEN-RTLSIKEASFSDRGVYKCVASNA 2030
C A G P P I W+ + + S RI + N TL+I A SD G Y CVA+N
Sbjct: 3268 CNANGIPTPLIQWLKDGKPI---ASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNP 3324
Query: 2031 AGADSLAIRLHVAALPPVI-HQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI 2089
AG + L+V P + ++++ E + SI+I C A P P + W L +G +
Sbjct: 3325 AGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW-LKNGLPL 3383
Query: 2090 RPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARIT 2149
S + + + I D Y CVA+N G + L V
Sbjct: 3384 PLSSHIR---LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSM 3440
Query: 2150 GTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANG-TLVV 2208
GT V G + + C G P P + W + + D+ + V +G L +
Sbjct: 3441 GT--EEITVLKGSSTSMACITDGTPAPSMAWLRDGQPL-----GLDAHLTVSTHGMVLQL 3493
Query: 2209 KSVTDKDAGDYLCVARNKVGD--DYVVLKVDVVMKPAKIEHKEENDH-KVFYGGDLKVDC 2265
+D+G Y C+A N+ G+ + +LK V++P I EE++ V L++ C
Sbjct: 3494 LKAETEDSGKYTCIASNEAGEVSKHFILK---VLEPPHINGSEEHEEISVIVNNPLELTC 3550
Query: 2266 VATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCF 2325
+A+G+P P+++W + DG + Q GG L + + + G YTC
Sbjct: 3551 IASGIPAPKMTW-MKDGRPLPQTDQVQTLGG---------GEVLRISTAQVEDTGRYTCL 3600
Query: 2326 AENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTN 2385
A + G D+ V+V P + V VT+ C++ P P +TWL
Sbjct: 3601 ASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGE 3660
Query: 2386 KVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKING 2444
++ ++ + +I G L I A D+ NYTC+ N AG+ + + VNV PP I G
Sbjct: 3661 RL--QATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV-PPNIKG 3717
Query: 2445 NPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLD 2504
P + + +++C AEG+PTPR+ W +G VL + R ++ NG L
Sbjct: 3718 GPQSLVILL-----NKSTVLECIAEGVPTPRITWR-KDGAVLAGNH--ARYSILENGFLH 3769
Query: 2505 IRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNC 2564
I+S +D+ + +CMA N G R + L V P P +T + +L C
Sbjct: 3770 IQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIA----PGPTNMTVIVNVQTTLAC 3825
Query: 2565 SAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGH 2624
A G P PS+ W NG L Q + + G L I S D Y C N AG
Sbjct: 3826 EATGIPKPSINW-RKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGD 3884
Query: 2625 TERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQT 2684
+R V L V + P + + + + + CT G WT NG+ L P+
Sbjct: 3885 DKRTVDLTVQVPPSIADEPTDFL-VTKHAPAVITCTASGVPFPSIHWT-KNGIRLL-PRG 3941
Query: 2685 LGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIY 2744
G +L +G + + + G Y C G + + + + PP I +P+ ++
Sbjct: 3942 DG-YRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHV-TLHVHEPPVIQPQPSE-LH 3998
Query: 2745 TRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYG-NRFLHPQGSLTIQHATQR 2803
N + L C A G P ITW+ K G+ G N + P G L I A +
Sbjct: 3999 VILNNPILLPCEATGTPSPFITWQ-------KEGINVNTSGRNHAVLPSGGLQISRAVRE 4051
Query: 2804 DAGFYKCMAKNILGS 2818
DAG Y C+A+N G+
Sbjct: 4052 DAGTYMCVAQNPAGT 4066
Score = 312 bits (800), Expect = 3e-84
Identities = 270/973 (27%), Positives = 419/973 (43%), Gaps = 86/973 (8%)
Query: 1868 ETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLV-IRKVQVQDRGQY 1926
+T C ATG P P + W K ++ + R+ L G ++ I + QV D Y
Sbjct: 3357 DTSINIECRATGTPPPQINWLKNGLPLPLSSHIRL-----LAAGQVIRIVRAQVSDVAVY 3411
Query: 1927 MCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIF 1986
C ASN G+D L V + +++TV G + +M C+ GTPAP ++W+
Sbjct: 3412 TCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWL- 3470
Query: 1987 PDRRVWQTVSPVEGRITLHEN-RTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAAL 2045
R Q + ++ +T+ + L + +A D G Y C+ASN AG S L V
Sbjct: 3471 ---RDGQPLG-LDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEP 3526
Query: 2046 PPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPS---QFLHGNLFVF 2102
P + E+ E IS+ + + C A P P + W + DG + + Q L G
Sbjct: 3527 PHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTW-MKDGRPLPQTDQVQTLGGG---- 3581
Query: 2103 PNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTS-PRRTDVRYG 2161
L I +D+GRY C+A++ G + + V I GT PR V
Sbjct: 3582 --EVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVH---VPPNIAGTDEPRDITVLRN 3636
Query: 2162 GTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGT-LVVKSVTDKDAGDYL 2220
+ L+C + P P I W +R+ R+++ + G L + + D +Y
Sbjct: 3637 RQVTLECKSDAVPPPVITWLRNGERL-----QATPRVRILSGGRYLQINNADLGDTANYT 3691
Query: 2221 CVARNKVGDDY--VVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWS 2278
CVA N G +L V+V P I+ ++ + ++C+A G+P P I+W
Sbjct: 3692 CVASNIAGKTTREFILTVNV---PPNIKGGPQS-LVILLNKSTVLECIAEGVPTPRITWR 3747
Query: 2279 LPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVR 2338
DG+++ G RY + NG L+ + + G Y C A N G D R+
Sbjct: 3748 -KDGAVL---------AGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRID 3797
Query: 2339 VKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKV-IPTSSEKYQI 2397
++V P+ T + V V T+ACEA G P P + W + + + + Y++
Sbjct: 3798 LQVHVPPSIAPGPTNMTVIVNVQ--TTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRL 3855
Query: 2398 YQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAA 2457
G+L+I D+ Y C V N AG+D++TV + V V PP I P + A
Sbjct: 3856 LSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQV-PPSIADEPTDFLVTKHAPA 3914
Query: 2458 GGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLV 2517
+I C A G+P P + W +LP G+ + +G+++I + + + + +
Sbjct: 3915 -----VITCTASGVPFPSIHWTKNGIRLLPR---GDGYRILSSGAIEILATQLNHAGRYT 3966
Query: 2518 CMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWV 2577
C+ARN G A + L V EP P+ SE + + + I L C A GTP+P + W
Sbjct: 3967 CVARNAAGSAHRHVTLHVHEP---PVIQPQPSE-LHVILNNPILLPCEATGTPSPFITWQ 4022
Query: 2578 LPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP 2637
SG+ G L IS DAG Y CVA+N AG + L V + P
Sbjct: 4023 KEGINVNTSGRNHAVL---PSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPP 4079
Query: 2638 EANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLG--RVSLLDNGT 2695
+ V ++ + + L C G +W H +G + R +L +G+
Sbjct: 4080 VISPHLKEYVIAVD-KPITLSCEADGLPPPDITW------HKDGRAIVESIRQRVLSSGS 4132
Query: 2696 LTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVK-LN 2754
L + D G Y C G S TS + + PPRI S T YT N+ L
Sbjct: 4133 LQIAFVQPGDAGHYTCMAANVAGSSSTSTK-LTVHVPPRIRS--TEGHYTVNENSQAILP 4189
Query: 2755 CMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKN 2814
C+A GIP I W+ + + A L G P G L +++ D+GFY C+A N
Sbjct: 4190 CVADGIPTPAINWKKDNV------LLANLLGKYTAEPYGELILENVVLEDSGFYTCVANN 4243
Query: 2815 ILGSDSKTTYIHV 2827
G D+ T + V
Sbjct: 4244 AAGEDTHTVSLTV 4256
Score = 311 bits (797), Expect = 6e-84
Identities = 274/1016 (26%), Positives = 427/1016 (42%), Gaps = 72/1016 (7%)
Query: 1825 SSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPF 1884
S F++ + AG A F+ + E P ++ + P V+VT V C
Sbjct: 492 SDEGFYECIAVSSAGTGRAQTFFDVSEPPPVI-QVPNNVTVTPGERAVLTCLIISAVDYN 550
Query: 1885 VTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLS 1944
+TW + + RI+ L N +L ++ V+ D G+Y C S+ G V L
Sbjct: 551 LTWQRNDRDVRLAEPARIR---TLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFL- 606
Query: 1945 VTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITL 2004
TVQ+P + ++ + G +++ C A G P P+I+W D + + R +
Sbjct: 607 -TVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS-----HRYRM 660
Query: 2005 HENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLS 2064
+ TL IK A+ D G+Y C+ASN+AG D L P ++ + ++L G
Sbjct: 661 TSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVAL--GDI 718
Query: 2065 IHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVA 2124
+ C P P V+W GD ++RPS FL + + G L I+ D+G Y CVA
Sbjct: 719 TVMECKTSGIPPPQVKWFKGD-LELRPSTFLIIDPLL---GLLKIQETQDLDAGDYTCVA 774
Query: 2125 ANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILW-RLP 2183
N G A + L+V + + P + G + L C G P P I W RL
Sbjct: 775 INEAGRATGKITLDV----GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLD 830
Query: 2184 SKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPA 2243
+ + FS S I G L + ++ D G Y+C A N+ G V V A
Sbjct: 831 NMPIFSRPFSVSS-ISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVA 889
Query: 2244 KIEHKEENDHKVFYGGDLKVDC-VATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYV 2302
+ + V G L + C + G P PE W L+ +
Sbjct: 890 PLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLL-----------QNPYIT 938
Query: 2303 VFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGD 2362
V ++G+L+ V +++ G+YTC A N G + V V P TI++ + + G
Sbjct: 939 VRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLP-TIQHGQQILSTIE-GI 996
Query: 2363 VVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRN 2422
VT+ C+A G P P V W S ++I TSS K+ DG+L + +SG Y C N
Sbjct: 997 PVTLPCKASGNPKPSVIW-SKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATN 1055
Query: 2423 SAGEDRKTVWIHVNVQPPKINGNPNPITTVREI---AAGGSRKLIDCKAEGIPTPRVLWA 2479
+AG ++ V + V V+ P++ G+ ++ + + G + C+ + +P P + WA
Sbjct: 1056 TAGYAKRKVQLTVYVR-PRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWA 1114
Query: 2480 FPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPM 2539
++ P + R T +GS+ I R SDS +C+A N G ++L V P
Sbjct: 1115 KETQLISP---FSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP 1171
Query: 2540 EKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADG 2599
+ I P + + G + + C+A GTP P + W T L G + DG
Sbjct: 1172 K--IQRGP--KHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDG---EHHVSNPDG 1224
Query: 2600 MLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV-------GLKPEANKQYHNLVSIING 2652
L I + DAG Y CVA N AG E ++L V L+P N + V+
Sbjct: 1225 TLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVA---N 1281
Query: 2653 ETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGT-LTVREASVFDRGTYVC 2711
+ ++ PC G + W L NG L G + +S+L++GT L + + +D G Y+C
Sbjct: 1282 QRIEFPCPAKGTPKPTIKW-LHNGRELTGREP--GISILEDGTLLVIASVTPYDNGEYIC 1338
Query: 2712 RMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPD 2771
E G + + V P E + L C G P I W +
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN 1398
Query: 2772 KSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
++ + + L + AT DAG Y C A NI G+ K I V
Sbjct: 1399 VQVTESSTIQTVNNGKI------LKLFRATPEDAGRYSCKAINIAGTSQKYFNIDV 1448
Score = 306 bits (785), Expect = 1e-82
Identities = 286/1006 (28%), Positives = 428/1006 (42%), Gaps = 85/1006 (8%)
Query: 1843 ASKFWSLGEK--PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNT 1900
A K+++L P ++ + ++V CE +G P P ++W K + NT
Sbjct: 2952 AKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNT 3011
Query: 1901 RIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQD- 1959
I V TL I + +V D G+Y C A N G + S+TV P + H +
Sbjct: 3012 LI----VPGGRTLQIIRAKVSDGGEYTCIAINQAGESKK--KFSLTVYVPPSIKDHDSES 3065
Query: 1960 ---VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEAS 2016
V V G ++++EC + P P I+W R + ++ + VE L + + L IK+A
Sbjct: 3066 LSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITES-THVE---ILADGQMLHIKKAE 3121
Query: 2017 FSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEK---LENISLPPGLSIHIHCTAKA 2073
SD G Y C A N AG D L+V P + E+ +E IS P + + C A
Sbjct: 3122 VSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNP----VTLTCDATG 3177
Query: 2074 APLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARR 2133
P P++ W L + +I S L + + L I DSG Y C+A+N+ G A++
Sbjct: 3178 IPPPTIAW-LKNHKRIENSDSLEVRI-LSGGSKLQIARSQHSDSGNYTCIASNMEGKAQK 3235
Query: 2134 TVQLNVQ--RAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDAL 2191
L++Q + A A I P V G ++L C+A+G P P I W K +
Sbjct: 3236 YYFLSIQVPPSVAGAEI----PSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIAS-- 3289
Query: 2192 FSFDSRIKVFANG-TLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEE 2250
RI+V ANG TL + D G Y CVA N G++ + ++V + P +K+E
Sbjct: 3290 -GETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDE 3348
Query: 2251 NDH-KVFYGGDLKVDCVATGLPNPEISW-----SLPDGSLVNSFMQSDDSGGRTKRYVVF 2304
+ + ++C ATG P P+I+W LP S + + G+ R V
Sbjct: 3349 AEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLL-----AAGQVIRIV-- 3401
Query: 2305 NNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVV 2364
+ + YTC A N+ G D ++V P + + V G
Sbjct: 3402 --------RAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSST 3453
Query: 2365 TVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQ--KAQRSDSGNYTCLVRN 2422
++AC G P P + WL P + + +++Q KA+ DSG YTC+ N
Sbjct: 3454 SMACITDGTPAPSMAWLRDGQ---PLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASN 3510
Query: 2423 SAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKL-IDCKAEGIPTPRVLWAFP 2481
AGE K + V ++PP ING+ EI+ + L + C A GIP P++ W
Sbjct: 3511 EAGEVSKHFILKV-LEPPHINGSEEH----EEISVIVNNPLELTCIASGIPAPKMTW-MK 3564
Query: 2482 EGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEK 2541
+G P P T+ G L I + + D+ + C+A + G+ + V P
Sbjct: 3565 DG--RPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNI 3622
Query: 2542 PIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGML 2601
+P IT + ++L C + P P + W L NG LQ+ +++ L
Sbjct: 3623 AGTDEP--RDITVLRNRQVTLECKSDAVPPPVITW-LRNGERLQATPRVRIL--SGGRYL 3677
Query: 2602 HISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTP 2661
I+ D Y CVA N AG T R L V + P +LV ++N T+ L C
Sbjct: 3678 QINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTV-LECIA 3736
Query: 2662 PGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSV 2721
G R +W +G L G R S+L+NG L ++ A V D G Y+C G
Sbjct: 3737 EGVPTPRITWR-KDGAVLAGNH--ARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDR 3793
Query: 2722 TSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQA 2781
I + + PP I PT + T L C A GIPK I W HL V
Sbjct: 3794 RRID-LQVHVPPSIAPGPTNMTVIVNVQTT-LACEATGIPKPSINWR--KNGHL-LNVDQ 3848
Query: 2782 RLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
R L GSL I + D Y+C N G D +T + V
Sbjct: 3849 NQNSYRLL-SSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTV 3893
Score = 306 bits (783), Expect = 2e-82
Identities = 266/968 (27%), Positives = 419/968 (43%), Gaps = 81/968 (8%)
Query: 1857 TKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT-LVI 1915
T P+ ++V C++ P P +TW + TP RI L G L I
Sbjct: 3625 TDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRI-----LSGGRYLQI 3679
Query: 1916 RKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAK 1975
+ D Y C ASN+ G +L+V V P + Q + + L + +EC+A+
Sbjct: 3680 NNADLGDTANYTCVASNIAGKTTREFILTVNV--PPNIKGGPQSLVILLNKSTVLECIAE 3737
Query: 1976 GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS 2035
G P P+I+W R+ ++ R ++ EN L I+ A +D G Y C+A+NAAG D
Sbjct: 3738 GVPTPRITW----RKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDR 3793
Query: 2036 LAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFL 2095
I L V P + N+++ + + C A P PS+ W +G + Q
Sbjct: 3794 RRIDLQVHVPPSIAPGPT--NMTVIVNVQTTLACEATGIPKPSINW-RKNGHLLNVDQN- 3849
Query: 2096 HGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRR 2155
+ + +G+L I + + D+ YEC N G +RTV L VQ + A P
Sbjct: 3850 QNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIA----DEPTD 3905
Query: 2156 TDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKD 2215
V + C+ASG P+P I W R++ + ++ ++G + + +
Sbjct: 3906 FLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGY----RILSSGAIEILATQLNH 3961
Query: 2216 AGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEI 2275
AG Y CVARN G + + + V P + + ++ V + + C ATG P+P I
Sbjct: 3962 AGRYTCVARNAAGSAHRHVTLHVHEPP--VIQPQPSELHVILNNPILLPCEATGTPSPFI 4019
Query: 2276 SWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEM 2335
+W +G VN+ SG + + V +G L + + G Y C A+N G
Sbjct: 4020 TWQ-KEGINVNT------SG---RNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALG 4069
Query: 2336 RVRVKVVTAPATIRN-KTY-LAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSE 2393
++++ V P + K Y +AV P +T++CEA G P P +TW ++ S
Sbjct: 4070 KIKLNVQVPPVISPHLKEYVIAVDKP----ITLSCEADGLPPPDITWHKDGRAIV--ESI 4123
Query: 2394 KYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVR 2453
+ ++ G+L I Q D+G+YTC+ N AG + + V+V PP+I T V
Sbjct: 4124 RQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHV-PPRIRSTEGHYT-VN 4181
Query: 2454 EIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDS 2513
E S+ ++ C A+GIPTP + W + VL A G + T G L + ++ DS
Sbjct: 4182 E----NSQAILPCVADGIPTPAINWK--KDNVLLANLLG-KYTAEPYGELILENVVLEDS 4234
Query: 2514 VQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPS 2573
C+A N GE + LTV P F + + ++ G + L+C A G P P
Sbjct: 4235 GFYTCVANNAAGEDTHTVSLTV---HVLPTFTE-LPGDVSLNKGEQLRLSCKATGIPLPK 4290
Query: 2574 LVWVLPNGTDLQSGQQLQRFYHKADGM--LHISGLSSVDAGAYRCVARNAAGHTERLVSL 2631
L W N + + +G L I +S D+G Y C A N+ G + + +
Sbjct: 4291 LTWTFNNNI-------IPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFV 4343
Query: 2632 KVGLKPEANKQY-HNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSL 2690
V P Y N + + G + L C G W G+ +E R+
Sbjct: 4344 YVKEPPVFKGDYPSNWIEPLGGNAI-LNCEVKGDPTPTIQWNR-KGVDIEISH---RIRQ 4398
Query: 2691 LDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNT 2750
L NG+L + D G Y C E G S+ + + PP IT EP + G
Sbjct: 4399 LGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMS-LTLQSPPIITLEPVETVINAGGKI 4457
Query: 2751 VKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKC 2810
+ LNC A G P+ ITW S + + + N SL I A + D ++C
Sbjct: 4458 I-LNCQATGEPQPTITWSRQGHS-ISWDDRVNVLSN------NSLYIADAQKEDTSEFEC 4509
Query: 2811 MAKNILGS 2818
+A+N++GS
Sbjct: 4510 VARNLMGS 4517
Score = 295 bits (754), Expect = 6e-79
Identities = 252/977 (25%), Positives = 415/977 (42%), Gaps = 84/977 (8%)
Query: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTK----VSTGALMTPNTRIQRFEVLKNGTLVIR 1916
+ ++V + T C G P P + W + + A +T +T ++LK
Sbjct: 3443 EEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLK------- 3495
Query: 1917 KVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASH-YQDVTVYLGDTIAMECLAK 1975
+ +D G+Y C ASN G +L V ++ P I S +++++V + + + + C+A
Sbjct: 3496 -AETEDSGKYTCIASNEAGEVSKHFILKV-LEPPHINGSEEHEEISVIVNNPLELTCIAS 3553
Query: 1976 GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS 2035
G PAP+++W+ R + QT + TL L I A D G Y C+AS+ AG D
Sbjct: 3554 GIPAPKMTWMKDGRPLPQT----DQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDD 3609
Query: 2036 LAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVL-GDGTQIRPS-Q 2093
+ V P + ++ +I++ + + C + A P P + W+ G+ Q P +
Sbjct: 3610 KEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVR 3669
Query: 2094 FLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSP 2153
L G + L I N D+ Y CVA+N+ G R L V I G P
Sbjct: 3670 ILSGGRY------LQINNADLGDTANYTCVASNIAGKTTREFILTVN---VPPNIKG-GP 3719
Query: 2154 RRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTD 2213
+ + + L+C A G P PRI WR L +R + NG L ++S
Sbjct: 3720 QSLVILLNKSTVLECIAEGVPTPRITWRKDGA----VLAGNHARYSILENGFLHIQSAHV 3775
Query: 2214 KDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNP 2273
D G YLC+A N G D + + V + P+ + V + C ATG+P P
Sbjct: 3776 TDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGP--TNMTVIVNVQTTLACEATGIPKP 3833
Query: 2274 EISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKD 2333
I+W +G L+N + Y + ++G+L + + Y C N G D
Sbjct: 3834 SINWR-KNGHLLNVDQNQNS-------YRLLSSGSLVIISPSVDDTATYECTVTNGAGDD 3885
Query: 2334 EMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSE 2393
+ V + V P+ T V V+T C A G P P + W +++P +
Sbjct: 3886 KRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT--CTASGVPFPSIHWTKNGIRLLPRG-D 3942
Query: 2394 KYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVR 2453
Y+I G + I Q + +G YTC+ RN+AG + V +HV+ +PP I P+ + +
Sbjct: 3943 GYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVH-EPPVIQPQPSELHVIL 4001
Query: 2454 EIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDS 2513
+ L+ C+A G P+P + W EG+ + G V +G L I + D+
Sbjct: 4002 N-----NPILLPCEATGTPSPFITWQ-KEGINVNTS--GRNHAVLPSGGLQISRAVREDA 4053
Query: 2514 VQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPS 2573
+C+A+N G A ++L V P P+ + E + A+ I+L+C A G P P
Sbjct: 4054 GTYMCVAQNPAGTALGKIKLNVQVP---PVISPHLKEYVIAV-DKPITLSCEADGLPPPD 4109
Query: 2574 LVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV 2633
+ W ++S +Q + G L I+ + DAG Y C+A N AG + L V
Sbjct: 4110 ITWHKDGRAIVESIRQRVL----SSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV 4165
Query: 2634 GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN 2693
+ P + N + + LPC G +W N + LG+ +
Sbjct: 4166 HVPPRIRSTEGHYTVNENSQAI-LPCVADGIPTPAINWKKDNVLLAN---LLGKYTAEPY 4221
Query: 2694 GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKL 2753
G L + + D G Y C G ++ + V P T P V + G ++L
Sbjct: 4222 GELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPT-FTELPGDVSLNK-GEQLRL 4279
Query: 2754 NCMAMGIPKADITWELPDK---SHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKC 2810
+C A GIP +TW + +H + ++ L I+ ++ D+G Y C
Sbjct: 4280 SCKATGIPLPKLTWTFNNNIIPAHFDS-----------VNGHSELVIERVSKEDSGTYVC 4328
Query: 2811 MAKNILGSDSKTTYIHV 2827
A+N +G +++V
Sbjct: 4329 TAENSVGFVKAIGFVYV 4345
Score = 281 bits (720), Expect = 5e-75
Identities = 255/991 (25%), Positives = 403/991 (40%), Gaps = 89/991 (8%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P + + P VS+ ++ PC G P+P + W ++ + + + L+ G
Sbjct: 792 PPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGA 851
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMEC 1972
L I + D+G Y+C A N G + ++VT ++ V G + + C
Sbjct: 852 LFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPC 911
Query: 1973 -LAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAA 2031
L G P P+ WI + Q IT+ + +L I+ D G Y CVASN A
Sbjct: 912 TLLAGNPIPERRWIKNSAMLLQ-----NPYITVRSDGSLHIERVQLQDGGEYTCVASNVA 966
Query: 2032 GADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRW-VLGDGTQIR 2090
G ++ + V LP + H +++ +S G+ + + C A P PSV W G+
Sbjct: 967 GTNNKTTSVVVHVLPTIQHGQQI--LSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS 1024
Query: 2091 PSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV---QRAAANAR 2147
++F G +G+LY+ + ++SG Y C A N G A+R VQL V R + R
Sbjct: 1025 SAKFSAG-----ADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQR 1079
Query: 2148 -ITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTL 2206
++ P V G + L C P P I W + + F R +G++
Sbjct: 1080 GLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITW----AKETQLISPFSPRHTFLPSGSM 1135
Query: 2207 VVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCV 2266
+ D+G YLCVA N G+ +K++V + P KI+ ++ KV G + + C
Sbjct: 1136 KITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV-PPKIQRGPKH-LKVQVGQRVDIPCN 1193
Query: 2267 ATGLPNPEISWSLPDGSLVNSFMQSDDSGGRT-----KRYVVFNNGTLYFNEVGMREEGD 2321
A G P P I+WS GG T + +V +GTL ++ + G
Sbjct: 1194 AQGTPLPVITWS---------------KGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGI 1238
Query: 2322 YTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDV---------VTVACEAKG 2372
YTC A N G DE + + V P T ++ PY + C AKG
Sbjct: 1239 YTCVATNIAGTDETEITLHVQEPP------TVEDLEPPYNTTFQERVANQRIEFPCPAKG 1292
Query: 2373 EPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTV 2431
P P + WL + + I +DGTLL I D+G Y C+ N AG +
Sbjct: 1293 TPKPTIKWLH-NGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKY 1351
Query: 2432 WIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYY 2491
+ V+V PP I + +T V + + C+ EG P+P ++W + + V +
Sbjct: 1352 NLKVHV-PPVIK-DKEQVTNVSVLL--NQLTNLFCEVEGTPSPIIMW-YKDNVQVTES-- 1404
Query: 2492 GNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEK 2551
TV+ L + D+ + C A N G ++ + VL P I +
Sbjct: 1405 STIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVP--PTIIGTNFPNE 1462
Query: 2552 ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDA 2611
++ + ++L C GTP P + W +G L G + +LH+ D
Sbjct: 1463 VSVVLNRDVALECQVKGTPFPDIHW-FKDGKPLFLGDPNVELLDRGQ-VLHLKNARRNDK 1520
Query: 2612 GAYRCVARNAAGHTERLVSLKVGLKPE-ANKQYHNLVSIINGETLKLPCTPPGAGQGRFS 2670
G Y+C NAAG + + L + + P +S++ +KL C G +
Sbjct: 1521 GRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAIT 1580
Query: 2671 WTLPNGMHLEGPQTLGRVSLLDNGT-LTVREASVFDRGTYVCRMETEYGPSVTSIPVIVI 2729
W + Q L +D G L + A V D TY C + G + S V V
Sbjct: 1581 WYKDGQPIMSSSQAL----YIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVY 1636
Query: 2730 AYPPRITSEPTPVIYTRP--GNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNR 2787
PP I + + +++ L C A G P +TW LK GV + N
Sbjct: 1637 V-PPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTW-------LKDGVPVKANDNI 1688
Query: 2788 FLHPQG-SLTIQHATQRDAGFYKCMAKNILG 2817
+ G L I A + D G Y C+A ++ G
Sbjct: 1689 RIEAGGKKLEIMSAQEIDRGQYICVATSVAG 1719
Score = 281 bits (718), Expect = 8e-75
Identities = 256/925 (27%), Positives = 392/925 (42%), Gaps = 75/925 (8%)
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMEC 1972
L I KV + D G Y C A + G R V+ P I + +VTV G+ + C
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPN--NVTVTPGERAVLTC 541
Query: 1973 LAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAG 2032
L ++W DR V + P RI N +L +K F+D G Y C+ S+ G
Sbjct: 542 LIISAVDYNLTWQRNDRDV-RLAEPA--RIRTLANLSLELKSVKFNDAGEYHCMVSSEGG 598
Query: 2033 ADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPS 2092
+ + ++ L V P V K N S G + I C+A P P + W + D
Sbjct: 599 SSAASVFLTVQEPPKVTVMPK--NQSFTGGSEVSIMCSATGYPKPKIAWTVND------- 649
Query: 2093 QFLHGN--LFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITG 2150
F+ G+ + +GTL+I+N APKD+G Y C+A+N G+ ++ L A +
Sbjct: 650 MFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQS 709
Query: 2151 TSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKS 2210
V G ++C SG P P++ W + + F + G L ++
Sbjct: 710 ----ELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLL----GLLKIQE 761
Query: 2211 VTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGL 2270
D DAGDY CVA N+ G + +DV P I+ E D + G ++ + C G
Sbjct: 762 TQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQ--EPADVSMEIGSNVTLPCYVQGY 819
Query: 2271 PNPEISWSLPDGSLVNS--FMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAEN 2328
P P I W D + S F S S RT G L+ + ++G Y C AEN
Sbjct: 820 PEPTIKWRRLDNMPIFSRPFSVSSISQLRT--------GALFILNLWASDKGTYICEAEN 871
Query: 2329 QVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACE-AKGEPMPKVTWLSPTNKV 2387
Q GK + V V A + + V G +T+ C G P+P+ W+ N
Sbjct: 872 QFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIK--NSA 929
Query: 2388 IPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPN 2447
+ + + DG+L I++ Q D G YTC+ N AG + KT + V+V P I
Sbjct: 930 MLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVL-PTIQHGQQ 988
Query: 2448 PITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRS 2507
++T+ I + CKA G P P V+W+ ++ + + + +GSL + S
Sbjct: 989 ILSTIEGIPV-----TLPCKASGNPKPSVIWSKKGELISTS---SAKFSAGADGSLYVVS 1040
Query: 2508 LRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDP--ISE----KITAMAGHTIS 2561
+S + VC A N G A+ +QLTV + +F D +S+ +I+ +AG ++
Sbjct: 1041 PGGEESGEYVCTATNTAGYAKRKVQLTVY--VRPRVFGDQRGLSQDKPVEISVLAGEEVT 1098
Query: 2562 LNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNA 2621
L C P P + W T L S R G + I+ + D+G Y CVA N
Sbjct: 1099 LPCEVKSLPPPIITWA--KETQLISPFS-PRHTFLPSGSMKITETRTSDSGMYLCVATNI 1155
Query: 2622 AGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNG-MHLE 2680
AG+ + V L V + P+ + +L + G+ + +PC G +W+ M ++
Sbjct: 1156 AGNVTQAVKLNVHVPPKIQRGPKHL-KVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVD 1214
Query: 2681 GPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPT 2740
G + +GTL++ +A+ D G Y C G T I + + PP +
Sbjct: 1215 GEHHVSN----PDGTLSIDQATPSDAGIYTCVATNIAGTDETEI-TLHVQEPPTVEDLEP 1269
Query: 2741 PVIYT---RPGN-TVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLT 2796
P T R N ++ C A G PK I W H + R G L L
Sbjct: 1270 PYNTTFQERVANQRIEFPCPAKGTPKPTIKW-----LHNGRELTGREPGISILEDGTLLV 1324
Query: 2797 IQHATQRDAGFYKCMAKNILGSDSK 2821
I T D G Y C+A N G+ +
Sbjct: 1325 IASVTPYDNGEYICVAVNEAGTTER 1349
Score = 276 bits (705), Expect = 3e-73
Identities = 265/1001 (26%), Positives = 408/1001 (40%), Gaps = 89/1001 (8%)
Query: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT-LVIRKVQ 1919
+ V V + CE TG P P +TW K P + ++ G L I VQ
Sbjct: 2487 EDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQ-----PLQEDEAHHIISGGRFLQITNVQ 2541
Query: 1920 VQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILA----SHYQDVTVYLGDTIAMECLAK 1975
V G+Y C AS+ G L+V V P I + +DVTV L ++ C A
Sbjct: 2542 VPHTGRYTCLASSPAGHKSRSFSLNVFVS-PTIAGVGSDGNPEDVTVILNSPTSLVCEAY 2600
Query: 1976 GTPAPQISWIFPDRRVWQTVSPVEGRITLH---ENRTLSIKEASFSDRGVYKCVASNAAG 2032
P I+W ++ +P+E + RTL I A + G Y CVA+N AG
Sbjct: 2601 SYPPATITW-------FKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG 2653
Query: 2033 ADSLAIRLHVAALPPVIHQEKLENISLPP-------GLSIHIHCTAKAAPLPSVRWVLGD 2085
+ V +PP+I++ L L P ++ + C A A P S+ W D
Sbjct: 2654 EMIKHYEVKVY-IPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYK-D 2711
Query: 2086 GTQIRPSQFLHGNLFVFPNG-TLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAA 2144
G ++ ++ + NG TL I+ D+GRY CVA+N+ G +N+Q +
Sbjct: 2712 GQPLKSDDHVN----IAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPS 2767
Query: 2145 NARI--------TGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDS 2196
++ TG + DV + L C + P P + W L S D
Sbjct: 2768 FQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGH----PLTSSDK 2823
Query: 2197 RIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKP----AKIEHKEEND 2252
+ + L + +DAG Y CVA N+ G+D + V V++ P A + EE
Sbjct: 2824 VLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVT 2883
Query: 2253 HKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFN 2312
V ++C+++G P P SW L+ S GR L
Sbjct: 2884 --VLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRI----------LQIL 2931
Query: 2313 EVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKG 2372
+ + G Y C AEN G + + V P+ I K+ + V + +++ CE G
Sbjct: 2932 NTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSE-NLTVVVNNFISLTCEVSG 2990
Query: 2373 EPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVW 2432
P P ++WL + I ++ + TL I +A+ SD G YTC+ N AGE +K
Sbjct: 2991 FPPPDLSWLK-NEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFS 3049
Query: 2433 IHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYG 2492
+ V V PP I + + +V + G S L +C++ +P P + W + G ++
Sbjct: 3050 LTVYV-PPSIKDHDSESLSVVNVREGTSVSL-ECESNAVPPPVITW-YKNGRMITE---S 3103
Query: 2493 NRITVHGNGS-LDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEK 2551
+ + +G L I+ SD+ Q VC A N G L V P P P E
Sbjct: 3104 THVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVP---PSIEGPEREV 3160
Query: 2552 ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDA 2611
I + ++L C A G P P++ W L N +++ L+ L I+ D+
Sbjct: 3161 IVETISNPVTLTCDATGIPPPTIAW-LKNHKRIENSDSLEVRILSGGSKLQIARSQHSDS 3219
Query: 2612 GAYRCVARNAAGHTERLVSLKVGLKPE-ANKQYHNLVSIINGETLKLPCTPPGAGQGRFS 2670
G Y C+A N G ++ L + + P A + + VS++ GE ++L C G
Sbjct: 3220 GNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQ 3279
Query: 2671 WTLPNGMHLEGPQTLGRVSLLDNG-TLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVI 2729
W L +G + +T R+ + NG TL + A D G Y C G + V
Sbjct: 3280 W-LKDGKPIASGET-ERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVY 3337
Query: 2730 AYPP-RITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGN-R 2787
P R + + T ++ + C A G P I W LK G+ L + R
Sbjct: 3338 VTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW-------LKNGLPLPLSSHIR 3390
Query: 2788 FLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHVF 2828
L + I A D Y C+A N G D+K + VF
Sbjct: 3391 LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVF 3431
Score = 275 bits (703), Expect = 5e-73
Identities = 258/969 (26%), Positives = 400/969 (41%), Gaps = 75/969 (7%)
Query: 1873 FPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTL-VIRKVQVQDRGQYMCTAS 1931
FPC A G PKP + W + G +T R +L++GTL VI V D G+Y+C A
Sbjct: 1286 FPCPAKGTPKPTIKW--LHNGRELTG--REPGISILEDGTLLVIASVTPYDNGEYICVAV 1341
Query: 1932 NLHGLDRMVVLLSVTVQQPQILASHYQ--DVTVYLGDTIAMECLAKGTPAPQISWIFPDR 1989
N G L V V P ++ Q +V+V L + C +GTP+P I W +
Sbjct: 1342 NEAGTTERKYNLKVHV--PPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNV 1399
Query: 1990 RVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVI 2049
+V ++ S ++ T++ + L + A+ D G Y C A N AG + V P +I
Sbjct: 1400 QVTES-STIQ---TVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 2050 HQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNG-TLY 2108
+S+ + + C K P P + W DG +P N+ + G L+
Sbjct: 1456 GTNFPNEVSVVLNRDVALECQVKGTPFPDIHW-FKDG---KPLFLGDPNVELLDRGQVLH 1511
Query: 2109 IRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDC 2168
++N D GRY+C +N G + ++L + + G V +KL+C
Sbjct: 1512 LKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKG--GNVTTDISVLINSLIKLEC 1569
Query: 2169 SASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG 2228
G P P I W + + S + + L + D+ Y C N G
Sbjct: 1570 ETRGLPMPAITWYKDGQ----PIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAG 1625
Query: 2229 DDYVVLKVDVVMKPAKIEHKEEN--DHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVN 2286
VDV + P IE + +V L ++C A G P+P ++W L DG V
Sbjct: 1626 TAEKSFHVDVYVPPM-IEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTW-LKDGVPVK 1683
Query: 2287 SFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPA 2346
+ G K + + E+ + G Y C A + G+ E++ V V+ PA
Sbjct: 1684 ANDNIRIEAGGKKLEI------MSAQEI---DRGQYICVATSVAGEKEIKYEVDVLVPPA 1734
Query: 2347 TIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGT-LLI 2405
V +++ + C G P P + WL + + ++I +G L+I
Sbjct: 1735 IEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI--DERDGFKILLNGRKLVI 1792
Query: 2406 QKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPP-KINGNPNPITTVREIAAGGSRKLI 2464
+AQ S++G Y C+ N+AG+ +K + V+V P K +G + + A +
Sbjct: 1793 AQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVA------L 1846
Query: 2465 DCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEG 2524
C A GIP P + W + V A GN L I D+ + C+A N
Sbjct: 1847 QCIANGIPNPSITWLKDDQPVNTAQ--GNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA 1904
Query: 2525 GEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
GE + +QL V EP ++E T + + + L C AAG P P + W N L
Sbjct: 1905 GETQQHIQLHVHEPPSLEDAGKMLNE--TVLVSNPVQLECKAAGNPVPVITWYKDNR--L 1960
Query: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYH 2644
SG F ++ ++ I DAG Y+CVA N+AG TE SL+V + P + +
Sbjct: 1961 LSGSTSMTFLNRGQ-IIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGS-N 2018
Query: 2645 NLVSIINGETLKLPCTPPGAGQGRFSWTL---PNGMHLEGPQTL--GRVSLLDNGTLTVR 2699
N+V+++ ++L C G +W P G Q L GR+ L +
Sbjct: 2019 NMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-------LALT 2071
Query: 2700 EASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMG 2759
A + D G Y C G I + V PP I E V V+L C +
Sbjct: 2072 SAQISDTGRYTCVAVNAAGEKQRDIDLRVYV-PPNIMGEEQNVSVLI-SQAVELLCQSDA 2129
Query: 2760 IPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSD 2819
IP +TW L D L + NR + L I+ A +D G Y C A N+ G
Sbjct: 2130 IPPPTLTW-LKDGHPLLKKPGLSISENRSV-----LKIEDAQVQDTGRYTCEATNVAGKT 2183
Query: 2820 SKTTYIHVF 2828
K ++++
Sbjct: 2184 EKNYNVNIW 2192
Score = 275 bits (702), Expect = 6e-73
Identities = 278/1072 (25%), Positives = 429/1072 (40%), Gaps = 81/1072 (7%)
Query: 1783 GPPAPPLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPP 1842
G PAP L T GSP ++ N V S ++ ++ + +G + + A G
Sbjct: 2037 GIPAPSL--TWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRY--TCVAVNAAGEK 2092
Query: 1843 ASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRI 1902
P + Q VSV C++ P P +TW K L P I
Sbjct: 2093 QRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSI 2152
Query: 1903 QRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTV 1962
L I QVQD G+Y C A+N+ G +++ V + +TV
Sbjct: 2153 SE----NRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTV 2208
Query: 1963 YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRI-TLHENRTLSIKEASFSDRG 2021
G+ I++ C + G P P + W ++ ++ GR+ L R L I A SD
Sbjct: 2209 IEGNLISLLCESSGIPPPNLIW---KKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAA 2265
Query: 2022 VYKCVASNAAGADSLAIRLHVAALPPVIHQ-EKLENISLPPGLSIHIHCTAKAAPLPSVR 2080
+Y CVASN AG L V P + + I + G SI + C + P P+V
Sbjct: 2266 LYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVT 2325
Query: 2081 WVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ 2140
W + DG P G + L ++N+ D+GRY CVA N+ G + L+V
Sbjct: 2326 W-MKDG---HPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVH 2381
Query: 2141 RAAANARITGT--SPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRI 2198
A I G SP V ++ L C ASG P P I W + S + +
Sbjct: 2382 ---APPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPV-----SLSNSV 2433
Query: 2199 KVFANGTLV-VKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFY 2257
++ + G ++ + T +DAG Y CV RN G++ + + V++ P + D KV
Sbjct: 2434 RILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKE 2493
Query: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
+ + C TG P PEI+W DG +Q D++ +++ L V +
Sbjct: 2494 KQSVTLTCEVTGNPVPEITWH-KDGQP----LQEDEA-----HHIISGGRFLQITNVQVP 2543
Query: 2318 EEGDYTCFAENQVGKDEMRVRVKVVTAPATI---RNKTYLAVQVPYGDVVTVACEAKGEP 2374
G YTC A + G + V +P + V V ++ CEA P
Sbjct: 2544 HTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYP 2603
Query: 2375 MPKVTWLSPTNKVIPTSSEKYQIYQDG-TLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWI 2433
+TW + S+ +I G TL I AQ ++G Y+C+ N AGE K +
Sbjct: 2604 PATITWFKDGTPL--ESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEV 2661
Query: 2434 HVNVQPPKINGNP--NPITTVREIAAGGSRKL-IDCKAEGIPTPRVLWAFPEGVVLPAPY 2490
V + PP IN P + +E+ + L ++C+A IP+ + W + +G L +
Sbjct: 2662 KVYI-PPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSW-YKDGQPLKS-- 2717
Query: 2491 YGNRITVHGNG-SLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEP--------MEK 2541
+ + + NG +L I+ + SD+ + C+A N GE L + + P +
Sbjct: 2718 -DDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGN 2776
Query: 2542 PIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGML 2601
+ E + + ISL C P P+L W +G L S ++ +L
Sbjct: 2777 MLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW-YKDGHPLTSSDKV--LILPGGRVL 2833
Query: 2602 HISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP---EANKQYHNLVSIINGETLKLP 2658
I DAG Y CVA N AG ++V + P AN V+++ ++ +
Sbjct: 2834 QIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIE 2893
Query: 2659 CTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNG-TLTVREASVFDRGTYVCRMETEY 2717
C G+ R SW LE L NG L + + D G YVC E
Sbjct: 2894 CLSSGSPAPRNSWQKDGQPLLEDDHH----KFLSNGRILQILNTQITDIGRYVCVAENTA 2949
Query: 2718 GPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKA 2777
G S + + PP + + + N + L C G P D++W LK
Sbjct: 2950 G-SAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSW-------LKN 3001
Query: 2778 GVQARLYGNRFLHPQG-SLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHVF 2828
+L N + P G +L I A D G Y C+A N G K + V+
Sbjct: 3002 EQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVY 3053
Score = 264 bits (674), Expect = 1e-69
Identities = 253/973 (26%), Positives = 407/973 (41%), Gaps = 75/973 (7%)
Query: 1863 VSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQD 1922
+SV + CE G P P +TW K + + Q + K L I + QV D
Sbjct: 1557 ISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS----QALYIDKGQYLHIPRAQVSD 1612
Query: 1923 RGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQ---DVTVYLGDTIAMECLAKGTPA 1979
Y C +N+ G + V V P ++ + + V + ++ +EC A G P+
Sbjct: 1613 SATYTCHVANVAGTAEKSFHVDVYV--PPMIEGNLATPLNKQVVIAHSLTLECKAAGNPS 1670
Query: 1980 PQISWIFPDRRVWQTVSPVEGRITLH---ENRTLSIKEASFSDRGVYKCVASNAAGADSL 2036
P ++W+ + PV+ + + L I A DRG Y CVA++ AG +
Sbjct: 1671 PILTWL-------KDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEI 1723
Query: 2037 AIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLH 2096
+ V P + ++ + + + C +P P++ W L DG I
Sbjct: 1724 KYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMW-LKDGQLIDERD--- 1779
Query: 2097 GNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRT 2156
G + L I ++G Y C+AAN G ++ ++ V + +G S R
Sbjct: 1780 GFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVH-VPPTIKSSGLS-ERV 1837
Query: 2157 DVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANG-TLVVKSVTDKD 2215
V+Y + L C A+G P P I W + + A +K+ ++G L + +D
Sbjct: 1838 VVKYK-PVALQCIANGIPNPSITWLKDDQPVNTA----QGNLKIQSSGRVLQIAKTLLED 1892
Query: 2216 AGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEI 2275
AG Y CVA N G+ +++ V P+ + + + V ++++C A G P P I
Sbjct: 1893 AGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVI 1952
Query: 2276 SWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEM 2335
+W D L++ G T + + + + G Y C A N G E+
Sbjct: 1953 TW-YKDNRLLS---------GSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATEL 2002
Query: 2336 RVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKY 2395
++V AP+ + +AV V + V + CEA+G P P +TWL + V + S
Sbjct: 2003 FYSLQVHVAPSISGSNNMVAVVV--NNPVRLECEARGIPAPSLTWLKDGSPV-SSFSNGL 2059
Query: 2396 QIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVRE 2454
Q+ G +L + AQ SD+G YTC+ N+AGE ++ + + V V PP I G ++ +
Sbjct: 2060 QVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV-PPNIMGEEQNVSVLIS 2118
Query: 2455 IAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGS-LDIRSLRKSDS 2513
A + C+++ IP P + W +L P +++ N S L I + D+
Sbjct: 2119 QAVE-----LLCQSDAIPPPTLTWLKDGHPLLKKP----GLSISENRSVLKIEDAQVQDT 2169
Query: 2514 VQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPS 2573
+ C A N G+ + + P I ++T + G+ ISL C ++G P P+
Sbjct: 2170 GRYTCEATNVAGKTEKNYNVNIWVPPN--IGGSDELTQLTVIEGNLISLLCESSGIPPPN 2227
Query: 2574 LVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV 2633
L+W L R L IS DA Y CVA N AG ++ +L+V
Sbjct: 2228 LIWKKKGSPVLTDSMGRVRIL-SGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQV 2286
Query: 2634 GLKPEANKQYHNLVSII--NGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLL 2691
++P + II G+++ L C G +W + +G L + V +L
Sbjct: 2287 YIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTW-MKDGHPLIKAK---GVEIL 2342
Query: 2692 DNG-TLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPV-IYTRPGN 2749
D G L ++ V D G YVC G + + V A P I + +P I N
Sbjct: 2343 DEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKN 2402
Query: 2750 TVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGN-RFLHPQGSLTIQHATQRDAGFY 2808
+V L C A GIP ITW K G L + R L L + T DAG Y
Sbjct: 2403 SVSLTCEASGIPLPSITW-------FKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQY 2455
Query: 2809 KCMAKNILGSDSK 2821
C+ +N G + K
Sbjct: 2456 TCVVRNAAGEERK 2468
Score = 261 bits (666), Expect = 9e-69
Identities = 218/832 (26%), Positives = 360/832 (43%), Gaps = 71/832 (8%)
Query: 2010 LSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHC 2069
L I + + SD G Y+C+A ++AG V+ PPVI N+++ PG + C
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPN--NVTVTPGERAVLTC 541
Query: 2070 TAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVG 2129
+A ++ W D +R ++ + N +L ++++ D+G Y C+ ++ G
Sbjct: 542 LIISAVDYNLTWQRND-RDVRLAE--PARIRTLANLSLELKSVKFNDAGEYHCMVSSEGG 598
Query: 2130 SARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMID 2189
S+ +V L VQ ++T P+ G + + CSA+G P P+I W + ++
Sbjct: 599 SSAASVFLTVQEPP---KVT-VMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVG 654
Query: 2190 ALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKE 2249
+ R ++ ++GTL +K+ KDAG Y C+A N G D + + P + +
Sbjct: 655 S-----HRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQS 709
Query: 2250 ENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN--G 2307
E V G ++C +G+P P++ W D L R +++ + G
Sbjct: 710 EL--LVALGDITVMECKTSGIPPPQVKWFKGDLEL------------RPSTFLIIDPLLG 755
Query: 2308 TLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVA 2367
L E + GDYTC A N+ G+ ++ + V + P I+ +++++ G VT+
Sbjct: 756 LLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEI--GSNVTLP 813
Query: 2368 CEAKGEPMPKVTWLSPTNKVI---PTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSA 2424
C +G P P + W N I P S + G L I SD G Y C N
Sbjct: 814 CYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQF 873
Query: 2425 GEDRKTVWIHVN-VQPPKINGNPNPITTVREIAAGGSRKLIDCKA-EGIPTPRVLWAFPE 2482
G+ + + V + P I +P+ + G + + C G P P W
Sbjct: 874 GKIQSETTVTVTGLVAPLIGISPSVANVIE-----GQQLTLPCTLLAGNPIPERRWIKNS 928
Query: 2483 GVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKP 2542
++L PY ITV +GSL I ++ D + C+A N G + V +
Sbjct: 929 AMLLQNPY----ITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVV--HVLPT 982
Query: 2543 IFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLH 2602
I H + ++ + G ++L C A+G P PS++W S +F ADG L+
Sbjct: 983 IQHG--QQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSA---KFSAGADGSLY 1037
Query: 2603 ISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNL-------VSIINGETL 2655
+ ++G Y C A N AG+ +R V L V ++P L +S++ GE +
Sbjct: 1038 VVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEV 1097
Query: 2656 KLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMET 2715
LPC +W L P + R + L +G++ + E D G Y+C + T
Sbjct: 1098 TLPCEVKSLPPPIITWAKET--QLISPFS-PRHTFLPSGSMKITETRTSDSGMYLC-VAT 1153
Query: 2716 EYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHL 2775
+VT + + PP+I P + + G V + C A G P ITW + L
Sbjct: 1154 NIAGNVTQAVKLNVHVPPKIQRGPKH-LKVQVGQRVDIPCNAQGTPLPVITWSKGGSTML 1212
Query: 2776 KAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
G + +P G+L+I AT DAG Y C+A NI G+D +HV
Sbjct: 1213 VDGE------HHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHV 1258
Score = 256 bits (654), Expect = 2e-67
Identities = 254/1008 (25%), Positives = 414/1008 (41%), Gaps = 97/1008 (9%)
Query: 1856 LTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT-LV 1914
++ S V+V CEA G P P +TW K + N +VL G L
Sbjct: 2014 ISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNG----LQVLSGGRILA 2069
Query: 1915 IRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLA 1974
+ Q+ D G+Y C A N G + + L V V P + Q+V+V + + + C +
Sbjct: 2070 LTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV--PPNIMGEEQNVSVLISQAVELLCQS 2127
Query: 1975 KGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRT-LSIKEASFSDRGVYKCVASNAAGA 2033
P P ++W+ + + +++ ENR+ L I++A D G Y C A+N AG
Sbjct: 2128 DAIPPPTLTWLKDGHPLLKKPG-----LSISENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 2034 DSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQ 2093
+++ P + ++L +++ G I + C + P P++ W + S
Sbjct: 2183 TEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSM 2242
Query: 2094 FLHGNLFVFPNGTLYIRNLAPK-DSGRYECVAANLVGSARRTVQLNVQRAAANARITGTS 2152
G + + G ++A K D+ Y CVA+N+ G+A++ L V +G+
Sbjct: 2243 ---GRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITN-SGSH 2298
Query: 2153 PRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLV-VKSV 2211
P V G ++ L+C G P P + W +I A +++ G ++ +K++
Sbjct: 2299 PTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKA-----KGVEILDEGHILQLKNI 2353
Query: 2212 TDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKI-EHKEENDHKVFYGGDLKVDCVATGL 2270
D G Y+CVA N G + V P+ I H+ + V + + C A+G+
Sbjct: 2354 HVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGI 2413
Query: 2271 PNPEISWSLPDG---SLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAE 2327
P P I+W DG SL NS SGGR R + + M + G YTC
Sbjct: 2414 PLPSITW-FKDGWPVSLSNSVRIL--SGGRMLRLM----------QTTMEDAGQYTCVVR 2460
Query: 2328 NQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKV 2387
N G++ + V+ P + T V+V VT+ CE G P+P++TW +
Sbjct: 2461 NAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPL 2520
Query: 2388 IPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPP----KI 2442
E + I G L I Q +G YTCL + AG ++ ++V V P
Sbjct: 2521 --QEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGS 2578
Query: 2443 NGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGS 2502
+GNP +T + S + C+A P + W F +G P N + G +
Sbjct: 2579 DGNPEDVTVIL-----NSPTSLVCEAYSYPPATITW-FKDGT--PLESNRNIRILPGGRT 2630
Query: 2503 LDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEP--MEKPIFHDP--ISEKITAMAGH 2558
L I + ++ ++ + C+A NE GE ++ V P + K P +++ +
Sbjct: 2631 LQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNN 2690
Query: 2559 TISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYH---KADG-MLHISGLSSVDAGAY 2614
T++L C A P+ SL W + GQ L+ H A+G L I D G Y
Sbjct: 2691 TLTLECEAYAIPSASLSW-------YKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRY 2743
Query: 2615 RCVARNAAGHTERLVSLKVGLKPEANKQYH--NLV---------SIINGETLKLPCTPPG 2663
CVA N AG E + + + P K + N++ +I + L C
Sbjct: 2744 TCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNA 2803
Query: 2664 AGQGRFSWTLPNGMHLEGPQTLGRVSLLDNG-TLTVREASVFDRGTYVCRMETEYGPSVT 2722
A +W +G L +V +L G L + A V D G Y C E G
Sbjct: 2804 APPPTLTW-YKDGHPLTSSD---KVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSL 2859
Query: 2723 SIPVIVIAYPPRI---TSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGV 2779
V V+ PP I S+ + + + C++ G P +W+ + L+
Sbjct: 2860 QYDVRVLV-PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDD- 2917
Query: 2780 QARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
++FL L I + D G Y C+A+N GS K ++V
Sbjct: 2918 -----HHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNV 2960
Score = 210 bits (534), Expect = 2e-53
Identities = 154/574 (26%), Positives = 249/574 (43%), Gaps = 43/574 (7%)
Query: 1852 KPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG 1911
+P ++ P + V + PCEATG P PF+TW K + NT + VL +G
Sbjct: 3986 EPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEG----INVNTSGRNHAVLPSG 4041
Query: 1912 TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAME 1971
L I + +D G YMC A N G + + + VQ P +++ H ++ + + I +
Sbjct: 4042 GLQISRAVREDAGTYMCVAQNPAG--TALGKIKLNVQVPPVISPHLKEYVIAVDKPITLS 4099
Query: 1972 CLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAA 2031
C A G P P I+W R + +++ R + + +L I D G Y C+A+N A
Sbjct: 4100 CEADGLPPPDITWHKDGRAIVESI-----RQRVLSSGSLQIAFVQPGDAGHYTCMAANVA 4154
Query: 2032 GADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRP 2091
G+ S + +L V P + E + ++ + C A P P++ W +
Sbjct: 4155 GSSSTSTKLTVHVPPRIRSTE--GHYTVNENSQAILPCVADGIPTPAINWKKDNVLLAN- 4211
Query: 2092 SQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGT 2151
L G P G L + N+ +DSG Y CVA N G TV L V + G
Sbjct: 4212 ---LLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGD 4268
Query: 2152 SPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSV 2211
+ G L+L C A+G P P++ W + +I A FDS V + LV++ V
Sbjct: 4269 ----VSLNKGEQLRLSCKATGIPLPKLTWTF-NNNIIPA--HFDS---VNGHSELVIERV 4318
Query: 2212 TDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLP 2271
+ +D+G Y+C A N VG + V V +P + ++ GG+ ++C G P
Sbjct: 4319 SKEDSGTYVCTAENSVGFVKAIGFV-YVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDP 4377
Query: 2272 NPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG 2331
P I W+ + S R NG+L + GDYTC A N+ G
Sbjct: 4378 TPTIQWNRKGVDIEIS-----------HRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAG 4426
Query: 2332 KDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTS 2391
E + + + + P + G + + C+A GEP P +TW + + +
Sbjct: 4427 VVERSMSLTLQSPPIITLEPVETVINA--GGKIILNCQATGEPQPTITWSRQGHSI--SW 4482
Query: 2392 SEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAG 2425
++ + + +L I AQ+ D+ + C+ RN G
Sbjct: 4483 DDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516
Score = 188 bits (477), Expect = 7e-47
Identities = 168/627 (26%), Positives = 265/627 (42%), Gaps = 65/627 (10%)
Query: 1773 HSHSTFHLDFGP---PAP---------PLLHTPQTTGSPSTNL----QNIPMVSSTQSSI 1816
H H T H+ P P P P+L + TG+PS + + I + +S ++
Sbjct: 3977 HRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHA 4036
Query: 1817 SFITSSVQSSGSFHQSSSKFFA-----GGPPASKFWSLGEKPQILTKSPQTVSVTAETDT 1871
+ +Q S + + + + G K + P +++ + + +
Sbjct: 4037 VLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPI 4096
Query: 1872 VFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTAS 1931
CEA G P P +TW K + + R VL +G+L I VQ D G Y C A+
Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIVESIRQR-----VLSSGSLQIAFVQPGDAGHYTCMAA 4151
Query: 1932 NLHGLDRMVVLLSVTVQQPQILAS--HYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDR 1989
N+ G L+V V P+I ++ HY TV + C+A G P P I+W +
Sbjct: 4152 NVAGSSSTSTKLTVHVP-PRIRSTEGHY---TVNENSQAILPCVADGIPTPAINW----K 4203
Query: 1990 RVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVI 2049
+ ++ + G+ T L ++ D G Y CVA+NAAG D+ + L V LP
Sbjct: 4204 KDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFT 4263
Query: 2050 HQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYI 2109
E ++SL G + + C A PLP + W + I P+ F N + L I
Sbjct: 4264 --ELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNN--IIPAHFDSVN----GHSELVI 4315
Query: 2110 RNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCS 2169
++ +DSG Y C A N VG + + V+ G P GG L+C
Sbjct: 4316 ERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPV---FKGDYPSNWIEPLGGNAILNCE 4372
Query: 2170 ASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD 2229
GDP P I W +++ +D S RI+ NG+L + ++DAGDY CVA N+ G
Sbjct: 4373 VKGDPTPTIQW---NRKGVDIEISH--RIRQLGNGSLAIYGTVNEDAGDYTCVATNEAG- 4426
Query: 2230 DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFM 2289
V + + ++ I E + + GG + ++C ATG P P I+WS S+
Sbjct: 4427 -VVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSI----- 4480
Query: 2290 QSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIR 2349
DD R V +N +LY + + ++ C A N +G +RV V V +
Sbjct: 4481 SWDD------RVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQ 4534
Query: 2350 NKTYLAVQVPYGDVVTVACEAKGEPMP 2376
+ A V G + +P+P
Sbjct: 4535 WSAWRACSVTCGKGIQKRSRLCNQPLP 4561
Score = 164 bits (416), Expect = 9e-40
Identities = 161/647 (24%), Positives = 256/647 (39%), Gaps = 63/647 (9%)
Query: 2195 DSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHK 2254
D +K A+ L + VT D G Y C+A + G DV P I+ N+
Sbjct: 473 DQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQ--VPNNVT 530
Query: 2255 VFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEV 2314
V G + C+ + ++W D D R N +L V
Sbjct: 531 VTPGERAVLTCLIISAVDYNLTWQRND---------RDVRLAEPARIRTLANLSLELKSV 581
Query: 2315 GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATI---RNKTYLAVQVPYGDVVTVACEAK 2371
+ G+Y C ++ G V + V P +N+++ G V++ C A
Sbjct: 582 KFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTG-----GSEVSIMCSAT 636
Query: 2372 GEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTV 2431
G P PK+ W N + S +Y++ DGTL I+ A D+G Y CL NSAG D++
Sbjct: 637 GYPKPKIAWT--VNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNS 694
Query: 2432 WIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYY 2491
+ ++ PK+ + + A G +++CK GIP P+V W + + P+ +
Sbjct: 695 TLRY-IEAPKL-----MVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFL 748
Query: 2492 GNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEK 2551
I G L I+ + D+ C+A NE G A + L V P P+F ++
Sbjct: 749 ---IIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSP---PVFIQEPAD- 801
Query: 2552 ITAMAGHTISLNCSAAGTPTPSLVW-VLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVD 2610
++ G ++L C G P P++ W L N + G L I L + D
Sbjct: 802 VSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASD 861
Query: 2611 AGAYRCVARNAAGHTER--------LVSLKVGLKPEANKQYHNLVSIINGETLKLPCT-P 2661
G Y C A N G + LV+ +G+ P ++ ++I G+ L LPCT
Sbjct: 862 KGTYICEAENQFGKIQSETTVTVTGLVAPLIGISP-------SVANVIEGQQLTLPCTLL 914
Query: 2662 PGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSV 2721
G W + M L+ P +++ +G+L + + D G Y C G +
Sbjct: 915 AGNPIPERRWIKNSAMLLQNPY----ITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNN 970
Query: 2722 TSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQA 2781
+ V+V P ++ T G V L C A G PK + W K L + A
Sbjct: 971 KTTSVVVHVLP--TIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWS--KKGELISTSSA 1026
Query: 2782 RLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHVF 2828
+ GSL + ++G Y C A N G + + V+
Sbjct: 1027 KFSAG----ADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVY 1069
Score = 71.2 bits (173), Expect = 1e-11
Identities = 83/307 (27%), Positives = 127/307 (41%), Gaps = 40/307 (13%)
Query: 409 QDADEEALYYTGVR----AQILAEPEWVMQPSIDIQLNRR---QSTAKKVLLSYYTQYSQ 461
+D D E+L VR + E V P I N R +ST ++L + +
Sbjct: 3059 KDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIK 3118
Query: 462 TISTKDTRQARGRSW-------------VMIEPSGAVQRDQTVLE--GGPCQLSCNVKAS 506
DT Q R+ V + PS + ++E P L+C+
Sbjct: 3119 KAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGI 3178
Query: 507 ESPSIFWVLPDGSILKAPMDDPDS-KFSILSSGW-LRIKSMEPSDSGLYQCIAQVRDEMD 564
P+I W+ I ++ DS + ILS G L+I + SDSG Y CIA +
Sbjct: 3179 PPPTIAWLKNHKRI-----ENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKA 3233
Query: 565 RMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLAN 624
+ Y + +Q P + + + GE+V L CNA IP + W+ + I +
Sbjct: 3234 QKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIAS--GE 3291
Query: 625 TSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGADH--FTVGITVTKKGSGLPSKRGR 681
T + + NG TL+I SD+G Y CVA N G + F + + VT P+ RG
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVT------PTIRGN 3345
Query: 682 RPGAKAL 688
+ A+ L
Sbjct: 3346 KDEAEKL 3352
Score = 71.2 bits (173), Expect = 1e-11
Identities = 61/213 (28%), Positives = 93/213 (43%), Gaps = 9/213 (4%)
Query: 456 YTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVL 515
YT + I+ K TR+ V G Q +L L C + +P I W
Sbjct: 3690 YTCVASNIAGKTTREFILTVNVPPNIKGGPQ-SLVILLNKSTVLECIAEGVPTPRITW-R 3747
Query: 516 PDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSP 575
DG++L +++SIL +G+L I+S +D+G Y C+A DR + V P
Sbjct: 3748 KDGAVLAGN----HARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVP 3803
Query: 576 STQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGT 635
+ +T+ N TL C A IP+ ++W N ++N N + +L +G+
Sbjct: 3804 PSIAPGPTNMTVIVNV--QTTLACEATGIPKPSINW-RKNGHLLNVDQNQNSYRLLSSGS 3860
Query: 636 LSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
L I V D+ Y C N G D TV +TV
Sbjct: 3861 LVIISPSVDDTATYECTVTNGAGDDKRTVDLTV 3893
Score = 70.5 bits (171), Expect = 2e-11
Identities = 52/173 (30%), Positives = 77/173 (44%), Gaps = 11/173 (6%)
Query: 496 PCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQC 555
P LSC P I W +I+++ + +LSSG L+I ++P D+G Y C
Sbjct: 4095 PITLSCEADGLPPPDITWHKDGRAIVES------IRQRVLSSGSLQIAFVQPGDAGHYTC 4148
Query: 556 IAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPN 615
+A ++ V P + + T+ +N LPC A IP ++W N
Sbjct: 4149 MAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNEN--SQAILPCVADGIPTPAINWKKDN 4206
Query: 616 RRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
+ N L + P G L + V + DSG+Y CVA N G D TV +TV
Sbjct: 4207 VLLANLLGKYTAE---PYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV 4256
Score = 70.1 bits (170), Expect = 3e-11
Identities = 54/180 (30%), Positives = 79/180 (43%), Gaps = 12/180 (6%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
+VL G L C VK+ P I W I +P + + L SG ++I SD
Sbjct: 1090 SVLAGEEVTLPCEVKSLPPPIITWAKETQLI--SPFSP---RHTFLPSGSMKITETRTSD 1144
Query: 550 SGLYQCIA-QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAH 608
SG+Y C+A + + + V + P Q K + G+ V +PCNA P
Sbjct: 1145 SGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKH---LKVQVGQRVDIPCNAQGTPLPV 1201
Query: 609 LSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
++W ++ D H P+GTLSI + SD+G Y CVA N G D + + V
Sbjct: 1202 ITWSKGGSTMLVD---GEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHV 1258
Score = 69.3 bits (168), Expect = 5e-11
Identities = 59/215 (27%), Positives = 91/215 (42%), Gaps = 28/215 (13%)
Query: 456 YTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQ-TVLEGGPCQLSCNVKASESPSIFWV 514
YT + ++ K + WV G+ + Q TV+EG L C P++ W
Sbjct: 2172 YTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWK 2231
Query: 515 LPDGSILKAPMDDPDSKFSILSSG-WLRIKSMEPSDSGLYQCIAQ-----VRDEMDRMVY 568
+L M + ILS G L+I E SD+ LY C+A + E + VY
Sbjct: 2232 KKGSPVLTDSM----GRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVY 2287
Query: 569 -RVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIIN----DLA 623
R + + + P E I G+S++L C IP ++W+ +I ++
Sbjct: 2288 IRPTITNSGSHPTE-----IIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEIL 2342
Query: 624 NTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ H+ L N + VSD+G Y CVAVN G
Sbjct: 2343 DEGHILQLKN-------IHVSDTGRYVCVAVNVAG 2370
Score = 67.4 bits (163), Expect = 2e-10
Identities = 55/191 (28%), Positives = 84/191 (43%), Gaps = 17/191 (8%)
Query: 477 VMIEPSGAVQRDQTVL---EGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFS 533
V++ +Q Q +L EG P L C + PS+ W G ++ +KFS
Sbjct: 975 VVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWS-KKGELISTS----SAKFS 1029
Query: 534 ILSSGWLRIKSMEPSDSGLYQCIAQ-----VRDEMDRMVY-RVLVQSPSTQPAEKDTVTI 587
+ G L + S +SG Y C A + ++ VY R V ++ V I
Sbjct: 1030 AGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEI 1089
Query: 588 GKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSG 647
GE VTLPC ++P ++W + I + H + LP+G++ I + + SDSG
Sbjct: 1090 SVLAGEEVTLPCEVKSLPPPIITWAKETQLI--SPFSPRHTF-LPSGSMKITETRTSDSG 1146
Query: 648 YYRCVAVNQQG 658
Y CVA N G
Sbjct: 1147 MYLCVATNIAG 1157
Score = 67.0 bits (162), Expect = 2e-10
Identities = 67/249 (26%), Positives = 108/249 (43%), Gaps = 21/249 (8%)
Query: 428 EPEWVMQPSIDIQLNRRQSTAKKVLLSYYTQYSQTIS-----TKDTRQARGRSWVMIEPS 482
+P Q ++ IQ + R K LL +Y+ + T+ Q +E +
Sbjct: 1865 QPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDA 1924
Query: 483 GAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWL-R 541
G + ++TVL P QL C + P I W D +L + + L+ G +
Sbjct: 1925 GKML-NETVLVSNPVQLECKAAGNPVPVITWY-KDNRLLSG-----STSMTFLNRGQIID 1977
Query: 542 IKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQ-SPSTQPAEKDTVTIGKNPGESVTLPCN 600
I+S + SD+G+Y+C+A + Y + V +PS + + NP V L C
Sbjct: 1978 IESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNP---VRLECE 2034
Query: 601 ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGT-LSIPKVQVSDSGYYRCVAVNQQGA 659
A IP L+W L + ++ +N V L G L++ Q+SD+G Y CVAVN G
Sbjct: 2035 ARGIPAPSLTW-LKDGSPVSSFSNGLQV--LSGGRILALTSAQISDTGRYTCVAVNAAGE 2091
Query: 660 DHFTVGITV 668
+ + V
Sbjct: 2092 KQRDIDLRV 2100
Score = 67.0 bits (162), Expect = 2e-10
Identities = 60/192 (31%), Positives = 88/192 (45%), Gaps = 24/192 (12%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG-WLRIKSME 546
D TV+ P L C + +I W DG+ L++ + IL G L+I + +
Sbjct: 2584 DVTVILNSPTSLVCEAYSYPPATITW-FKDGTPLES-----NRNIRILPGGRTLQILNAQ 2637
Query: 547 PSDSGLYQCIAQVRDEMDRMV--YRVLVQSPSTQPAEKDTVTIGKNPGE-------SVTL 597
++G Y C+A +E M+ Y V V P + D G +P E ++TL
Sbjct: 2638 EDNAGRYSCVAT--NEAGEMIKHYEVKVYIPPIIN-KGDLWGPGLSPKEVKIKVNNTLTL 2694
Query: 598 PCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQ 656
C A AIP A LSW + + +D HV + NG TL I + Q+SD+G Y CVA N
Sbjct: 2695 ECEAYAIPSASLSWYKDGQPLKSD----DHVNIAANGHTLQIKEAQISDTGRYTCVASNI 2750
Query: 657 QGADHFTVGITV 668
G D + +
Sbjct: 2751 AGEDELDFDVNI 2762
Score = 66.6 bits (161), Expect = 3e-10
Identities = 57/195 (29%), Positives = 87/195 (44%), Gaps = 19/195 (9%)
Query: 479 IEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG 538
I+ SG +R V++ P L C +PSI W+ D P++ I SSG
Sbjct: 1828 IKSSGLSER--VVVKYKPVALQCIANGIPNPSITWLKDD-----QPVNTAQGNLKIQSSG 1880
Query: 539 W-LRIKSMEPSDSGLYQCIA-QVRDEMDRMVYRVLVQSPSTQPAEK---DTVTIGKNPGE 593
L+I D+G Y C+A E + + + + PS + A K +TV + NP
Sbjct: 1881 RVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVS-NP-- 1937
Query: 594 SVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
V L C A P ++W NR + +TS ++ + I Q+SD+G Y+CVA
Sbjct: 1938 -VQLECKAAGNPVPVITWYKDNRLLSG---STSMTFLNRGQIIDIESAQISDAGIYKCVA 1993
Query: 654 VNQQGADHFTVGITV 668
+N GA + V
Sbjct: 1994 INSAGATELFYSLQV 2008
Score = 65.9 bits (159), Expect = 6e-10
Identities = 58/183 (31%), Positives = 87/183 (47%), Gaps = 24/183 (13%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSDSGLYQCIA 557
L C A S S+ W DG LK+ D +I ++G L+IK + SD+G Y C+A
Sbjct: 2694 LECEAYAIPSASLSWY-KDGQPLKS-----DDHVNIAANGHTLQIKEAQISDTGRYTCVA 2747
Query: 558 QVRDEMDRMVYRVLVQ-SPSTQPAEK--DTVTIGKNPGES--------VTLPCNALAIPE 606
D + + V +Q PS Q + + + G+N GE+ ++L C A P
Sbjct: 2748 SNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRN-GEAKDVIINNPISLYCETNAAPP 2806
Query: 607 AHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGADHFTVG 665
L+W + L ++ V +LP G L IP+ +V D+G Y CVAVN+ G D
Sbjct: 2807 PTLTWYKDG----HPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYD 2862
Query: 666 ITV 668
+ V
Sbjct: 2863 VRV 2865
Score = 65.5 bits (158), Expect = 7e-10
Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 13/184 (7%)
Query: 477 VMIEPSGAVQ-RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSIL 535
V + PS A + D V + P ++C PSI W I P D + IL
Sbjct: 3893 VQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWT--KNGIRLLPRGDG---YRIL 3947
Query: 536 SSGWLRIKSMEPSDSGLYQCIAQ-VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGES 594
SSG + I + + + +G Y C+A+ R V + + P QP + I NP
Sbjct: 3948 SSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNP--- 4004
Query: 595 VTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAV 654
+ LPC A P ++W + IN + + +LP+G L I + D+G Y CVA
Sbjct: 4005 ILLPCEATGTPSPFITW---QKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQ 4061
Query: 655 NQQG 658
N G
Sbjct: 4062 NPAG 4065
Score = 61.6 bits (148), Expect = 1e-08
Identities = 51/188 (27%), Positives = 76/188 (40%), Gaps = 12/188 (6%)
Query: 485 VQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSS--GWLRI 542
VQ + V G + C P + W K ++ S F I+ G L+I
Sbjct: 707 VQSELLVALGDITVMECKTSGIPPPQVKW-------FKGDLELRPSTFLIIDPLLGLLKI 759
Query: 543 KSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNAL 602
+ + D+G Y C+A +E R ++ + S ++ + G +VTLPC
Sbjct: 760 QETQDLDAGDYTCVAI--NEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQ 817
Query: 603 AIPEAHLSWI-LPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADH 661
PE + W L N I + + S + L G L I + SD G Y C A NQ G
Sbjct: 818 GYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQ 877
Query: 662 FTVGITVT 669
+TVT
Sbjct: 878 SETTVTVT 885
Score = 60.1 bits (144), Expect = 3e-08
Identities = 62/227 (27%), Positives = 95/227 (41%), Gaps = 13/227 (5%)
Query: 444 RQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQ-RDQTVLEGGPCQLSCN 502
R STA+ YT + + + D ++ R V +G + RD TVL L C
Sbjct: 3585 RISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECK 3644
Query: 503 VKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG-WLRIKSMEPSDSGLYQCIAQVRD 561
A P I W L +G L+A + ILS G +L+I + + D+ Y C+A
Sbjct: 3645 SDAVPPPVITW-LRNGERLQAT-----PRVRILSGGRYLQINNADLGDTANYTCVASNIA 3698
Query: 562 EMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIIND 621
+ + V P ++ I N +S L C A +P ++W + +
Sbjct: 3699 GKTTREFILTVNVPPNIKGGPQSLVILLN--KSTVLECIAEGVPTPRITWRKDGAVLAGN 3756
Query: 622 LANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
A S +L NG L I V+D+G Y C+A N G D + + V
Sbjct: 3757 HARYS---ILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV 3800
Score = 59.7 bits (143), Expect = 4e-08
Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 15/182 (8%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPS 548
TVL + C S +P W DG L ++D KF LS+G L+I + + +
Sbjct: 2883 TVLVNKSALIECLSSGSPAPRNSWQ-KDGQPL---LEDDHHKF--LSNGRILQILNTQIT 2936
Query: 549 DSGLYQCIAQVRDEMDRMVYRVLVQ-SPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
D G Y C+A+ + + + V PS + + +T+ N ++L C P
Sbjct: 2937 DIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVN--NFISLTCEVSGFPPP 2994
Query: 608 HLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGADHFTVGI 666
LSW L N + I NT ++P G TL I + +VSD G Y C+A+NQ G +
Sbjct: 2995 DLSW-LKNEQPIKLNTNT---LIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSL 3050
Query: 667 TV 668
TV
Sbjct: 3051 TV 3052
Score = 58.5 bits (140), Expect = 9e-08
Identities = 53/176 (30%), Positives = 79/176 (44%), Gaps = 18/176 (10%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPS 548
TVL+G ++C + +PS+ W L DG L D+ ++ + G L++ E
Sbjct: 3446 TVLKGSSTSMACITDGTPAPSMAW-LRDGQPLGL-----DAHLTVSTHGMVLQLLKAETE 3499
Query: 549 DSGLYQCIAQVR-DEMDRMVYRVLVQSPSTQPAEK--DTVTIGKNPGESVTLPCNALAIP 605
DSG Y CIA E+ + +++ P +E+ + I NP E L C A IP
Sbjct: 3500 DSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLE---LTCIASGIP 3556
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGAD 660
++W+ R L T V L G L I QV D+G Y C+A + G D
Sbjct: 3557 APKMTWMKDGR----PLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD 3608
Score = 57.8 bits (138), Expect = 2e-07
Identities = 52/184 (28%), Positives = 81/184 (44%), Gaps = 22/184 (11%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGS-ILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGL 552
G L C V+ P+I W D I P S S L +G L I ++ SD G
Sbjct: 807 GSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSV--SSISQLRTGALFILNLWASDKGT 864
Query: 553 YQCIAQ-----VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALA---I 604
Y C A+ ++ E V ++ P+ + + G+ +TLPC LA I
Sbjct: 865 YICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIE-----GQQLTLPCTLLAGNPI 919
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
PE WI + ++ + ++ + +G+L I +VQ+ D G Y CVA N G ++ T
Sbjct: 920 PERR--WIKNSAMLLQN----PYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTT 973
Query: 665 GITV 668
+ V
Sbjct: 974 SVVV 977
Score = 57.4 bits (137), Expect = 2e-07
Identities = 49/186 (26%), Positives = 79/186 (42%), Gaps = 14/186 (7%)
Query: 478 MIEP---SGAVQRDQ-TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFS 533
++EP +G+ + ++ +V+ P +L+C +P + W + DG P+ D +
Sbjct: 3523 VLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTW-MKDGR----PLPQTDQVQT 3577
Query: 534 ILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGE 593
+ LRI + + D+G Y C+A D Y V V P + I
Sbjct: 3578 LGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNR 3637
Query: 594 SVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGT-LSIPKVQVSDSGYYRCV 652
VTL C + A+P ++W+ R L T V +L G L I + D+ Y CV
Sbjct: 3638 QVTLECKSDAVPPPVITWLRNGER----LQATPRVRILSGGRYLQINNADLGDTANYTCV 3693
Query: 653 AVNQQG 658
A N G
Sbjct: 3694 ASNIAG 3699
Score = 57.4 bits (137), Expect = 2e-07
Identities = 48/181 (26%), Positives = 76/181 (41%), Gaps = 8/181 (4%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
+ TV+ L+C PSI W +G +L +D + + +LSSG L I S
Sbjct: 3812 NMTVIVNVQTTLACEATGIPKPSINW-RKNGHLLN--VDQNQNSYRLLSSGSLVIISPSV 3868
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
D+ Y+C D+ + VQ P + E + K+ +T C A +P
Sbjct: 3869 DDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT--CTASGVPFP 3926
Query: 608 HLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGIT 667
+ W R+ L +L +G + I Q++ +G Y CVA N G+ H V +
Sbjct: 3927 SIHWTKNGIRL---LPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLH 3983
Query: 668 V 668
V
Sbjct: 3984 V 3984
Score = 57.0 bits (136), Expect = 3e-07
Identities = 52/196 (26%), Positives = 86/196 (43%), Gaps = 19/196 (9%)
Query: 479 IEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG 538
I SG+ + V G L C V+ P++ W+ ++KA IL G
Sbjct: 2292 ITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKA------KGVEILDEG 2345
Query: 539 W-LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSP----STQPAEKDTVTIGKNPGE 593
L++K++ SD+G Y C+A M Y + V +P + ++ + KN
Sbjct: 2346 HILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKN--- 2402
Query: 594 SVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCV 652
SV+L C A IP ++W + L+N+ V +L G L + + + D+G Y CV
Sbjct: 2403 SVSLTCEASGIPLPSITWFKDGWPV--SLSNS--VRILSGGRMLRLMQTTMEDAGQYTCV 2458
Query: 653 AVNQQGADHFTVGITV 668
N G + G++V
Sbjct: 2459 VRNAAGEERKIFGLSV 2474
Score = 56.2 bits (134), Expect = 4e-07
Identities = 40/176 (22%), Positives = 74/176 (42%), Gaps = 19/176 (10%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
++Q+ G + C+ P I W + D I+ + ++ + S G L IK+
Sbjct: 619 KNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS------HRYRMTSDGTLFIKNAA 672
Query: 547 PSDSGLYQCIAQVRDEMDRMVYRV-LVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP 605
P D+G+Y C+A D+ + +++P + + + G+ + C IP
Sbjct: 673 PKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVA---LGDITVMECKTSGIP 729
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPN---GTLSIPKVQVSDSGYYRCVAVNQQG 658
+ W DL +++ + G L I + Q D+G Y CVA+N+ G
Sbjct: 730 PPQVKWFK------GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAG 779
Score = 55.8 bits (133), Expect = 6e-07
Identities = 46/172 (26%), Positives = 76/172 (44%), Gaps = 14/172 (8%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSDSGLYQCIA 557
+ C + P I W L +G L P+ S +L++G +RI + SD +Y C+A
Sbjct: 3362 IECRATGTPPPQINW-LKNG--LPLPLS---SHIRLLAAGQVIRIVRAQVSDVAVYTCVA 3415
Query: 558 QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRR 617
R +D Y + V +P T I G S ++ C P ++W+ R
Sbjct: 3416 SNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWL----R 3471
Query: 618 IINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQG--ADHFTVGI 666
L +H+ + +G L + K + DSG Y C+A N+ G + HF + +
Sbjct: 3472 DGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKV 3523
Score = 55.1 bits (131), Expect = 1e-06
Identities = 46/185 (24%), Positives = 82/185 (44%), Gaps = 16/185 (8%)
Query: 480 EPSGAVQ--RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSS 537
EP +Q + TV G L+C + ++ ++ W D + A ++ L++
Sbjct: 518 EPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAE----PARIRTLAN 573
Query: 538 GWLRIKSMEPSDSGLYQC-IAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVT 596
L +KS++ +D+G Y C ++ V+ + + P K+ G G V+
Sbjct: 574 LSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTG---GSEVS 630
Query: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHVY-MLPNGTLSIPKVQVSDSGYYRCVAVN 655
+ C+A P+ ++W + + I+ SH Y M +GTL I D+G Y C+A N
Sbjct: 631 IMCSATGYPKPKIAWTVNDMFIVG-----SHRYRMTSDGTLFIKNAAPKDAGIYGCLASN 685
Query: 656 QQGAD 660
G D
Sbjct: 686 SAGTD 690
Score = 55.1 bits (131), Expect = 1e-06
Identities = 47/173 (27%), Positives = 72/173 (41%), Gaps = 20/173 (11%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSIL---KAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
G + CN + + P I W ++L + + +PD G L I PSD+
Sbjct: 1185 GQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD--------GTLSIDQATPSDA 1236
Query: 551 GLYQCIAQVRDEMDRMVYRVLVQSPST----QPAEKDTVTIGKNPGESVTLPCNALAIPE 606
G+Y C+A D + VQ P T +P T + + + PC A P+
Sbjct: 1237 GIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQ-ERVANQRIEFPCPAKGTPK 1295
Query: 607 AHLSWILPNRRIINDLANTSHVYMLPNGT-LSIPKVQVSDSGYYRCVAVNQQG 658
+ W+ R + + +L +GT L I V D+G Y CVAVN+ G
Sbjct: 1296 PTIKWLHNGREL---TGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAG 1345
Score = 54.7 bits (130), Expect = 1e-06
Identities = 58/207 (28%), Positives = 86/207 (41%), Gaps = 16/207 (7%)
Query: 478 MIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSS 537
MIE + A ++ V+ L C + SP + W L DG +KA + I +
Sbjct: 1640 MIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTW-LKDGVPVKA-----NDNIRIEAG 1693
Query: 538 GW-LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVT 596
G L I S + D G Y C+A + Y V V P +T +
Sbjct: 1694 GKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLE 1753
Query: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
L C+ P + W L + ++I++ +L L I + QVS++G YRC+A N
Sbjct: 1754 LDCHVTGSPPPTIMW-LKDGQLIDE--RDGFKILLNGRKLVIAQAQVSNTGLYRCMAANT 1810
Query: 657 QGADH-----FTVGITVTKKGSGLPSK 678
G DH TV + T K SGL +
Sbjct: 1811 AG-DHKKEFEVTVHVPPTIKSSGLSER 1836
Score = 54.7 bits (130), Expect = 1e-06
Identities = 49/176 (27%), Positives = 80/176 (45%), Gaps = 25/176 (14%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSD 549
V+ P +L C + +PS+ W L DGS P+ + +LS G L + S + SD
Sbjct: 2023 VVVNNPVRLECEARGIPAPSLTW-LKDGS----PVSSFSNGLQVLSGGRILALTSAQISD 2077
Query: 550 SGLYQCIA-----QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
+G Y C+A + + ++D VY P E+ V++ + ++V L C + AI
Sbjct: 2078 TGRYTCVAVNAAGEKQRDIDLRVY-----VPPNIMGEEQNVSVLIS--QAVELLCQSDAI 2130
Query: 605 PEAHLSWILPNRRIIND--LANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
P L+W+ ++ L+ + + L I QV D+G Y C A N G
Sbjct: 2131 PPPTLTWLKDGHPLLKKPGLSISEN-----RSVLKIEDAQVQDTGRYTCEATNVAG 2181
Score = 53.9 bits (128), Expect = 2e-06
Identities = 48/179 (26%), Positives = 69/179 (38%), Gaps = 12/179 (6%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLY 553
GG L+C VK +P+I W I + + L +G L I D+G Y
Sbjct: 4364 GGNAILNCEVKGDPTPTIQWNRKGVDI------EISHRIRQLGNGSLAIYGTVNEDAGDY 4417
Query: 554 QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWIL 613
C+A + + +QSP E I N G + L C A P+ ++W
Sbjct: 4418 TCVATNEAGVVERSMSLTLQSPPIITLEPVETVI--NAGGKIILNCQATGEPQPTITWSR 4475
Query: 614 PNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKG 672
I D V +L N +L I Q D+ + CVA N G+ V + V G
Sbjct: 4476 QGHSISWD----DRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHG 4530
Score = 53.5 bits (127), Expect = 3e-06
Identities = 46/176 (26%), Positives = 72/176 (40%), Gaps = 20/176 (11%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
V+ P L C A+ P++ W DG P+ D + L+I + D+
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWY-KDGH----PLTSSDKVLILPGGRVLQIPRAKVEDA 2843
Query: 551 GLYQCIAQVRDEMDRMVYRV------LVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
G Y C+A D + Y V +++ ++ E+ TV + K S + C +
Sbjct: 2844 GRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNK----SALIECLSSGS 2899
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGA 659
P SW + ++ D H L NG L I Q++D G Y CVA N G+
Sbjct: 2900 PAPRNSWQKDGQPLLED----DHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS 2951
Score = 52.8 bits (125), Expect = 5e-06
Identities = 41/161 (25%), Positives = 63/161 (39%), Gaps = 9/161 (5%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSDSGLYQCIA 557
L C VK + P I W DG P+ D +L G L +K+ +D G YQC
Sbjct: 1473 LECQVKGTPFPDIHW-FKDGK----PLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTV 1527
Query: 558 QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRR 617
++ + P + T I + L C +P ++W +
Sbjct: 1528 SNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQP 1587
Query: 618 IINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
I ++++ +Y+ L IP+ QVSDS Y C N G
Sbjct: 1588 I---MSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAG 1625
Score = 52.0 bits (123), Expect = 8e-06
Identities = 48/191 (25%), Positives = 78/191 (40%), Gaps = 12/191 (6%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG-WLRIKSMEPS 548
+V+E L+C PSI W DG + + ILS G LR+
Sbjct: 2397 SVVEKNSVSLTCEASGIPLPSITW-FKDGWPVSL-----SNSVRILSGGRMLRLMQTTME 2450
Query: 549 DSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAH 608
D+G Y C+ + +R ++ + V P E + +SVTL C P
Sbjct: 2451 DAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPE 2510
Query: 609 LSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG--ADHFTVGI 666
++W + + D A H + L I VQV +G Y C+A + G + F++ +
Sbjct: 2511 ITWHKDGQPLQEDEA---HHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV 2567
Query: 667 TVTKKGSGLPS 677
V+ +G+ S
Sbjct: 2568 FVSPTIAGVGS 2578
Score = 52.0 bits (123), Expect = 8e-06
Identities = 45/181 (24%), Positives = 78/181 (43%), Gaps = 12/181 (6%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
D ++ +G +LSC P + W + +I+ A D S+ L I+ +
Sbjct: 4268 DVSLNKGEQLRLSCKATGIPLPKLTWTF-NNNIIPAHFD------SVNGHSELVIERVSK 4320
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
DSG Y C A+ + + V V+ P + + I G ++ L C P
Sbjct: 4321 EDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAI-LNCEVKGDPTP 4379
Query: 608 HLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGIT 667
+ W NR+ + D+ + + L NG+L+I D+G Y CVA N+ G ++ +T
Sbjct: 4380 TIQW---NRKGV-DIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLT 4435
Query: 668 V 668
+
Sbjct: 4436 L 4436
Score = 51.2 bits (121), Expect = 1e-05
Identities = 52/195 (26%), Positives = 78/195 (40%), Gaps = 20/195 (10%)
Query: 491 VLEGGPCQLSCNVKASES-PSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
V+EG L C + A P W+ +L+ P ++ S G L I+ ++ D
Sbjct: 901 VIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPY------ITVRSDGSLHIERVQLQD 954
Query: 550 SGLYQCIAQ----VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP 605
G Y C+A ++ +V VL P+ Q ++ TI G VTLPC A P
Sbjct: 955 GGEYTCVASNVAGTNNKTTSVVVHVL---PTIQHGQQILSTI---EGIPVTLPCKASGNP 1008
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVG 665
+ + W I A S +G+L + +SG Y C A N G V
Sbjct: 1009 KPSVIWSKKGELISTSSAKFSAG---ADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQ 1065
Query: 666 ITVTKKGSGLPSKRG 680
+TV + +RG
Sbjct: 1066 LTVYVRPRVFGDQRG 1080
Score = 50.4 bits (119), Expect = 2e-05
Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 4/129 (3%)
Query: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPC 599
L I + SD G Y+CIA R V P + VT+ PGE L C
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTV--TPGERAVLTC 541
Query: 600 NALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
++ + +L+W +R + LA + + L N +L + V+ +D+G Y C+ ++ G+
Sbjct: 542 LIISAVDYNLTWQRNDRDV--RLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGS 599
Query: 660 DHFTVGITV 668
+V +TV
Sbjct: 600 SAASVFLTV 608
Score = 48.9 bits (115), Expect = 7e-05
Identities = 42/174 (24%), Positives = 69/174 (39%), Gaps = 8/174 (4%)
Query: 486 QRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSM 545
+++ +VL +L C A P++ W+ +LK P S+ L+I+
Sbjct: 2110 EQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSV-----LKIEDA 2164
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP 605
+ D+G Y C A Y V + P + + G ++L C + IP
Sbjct: 2165 QVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIP 2224
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQG 658
+L W ++ D + V +L G L I + SD+ Y CVA N G
Sbjct: 2225 PPNLIWKKKGSPVLTD--SMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAG 2276
Score = 47.4 bits (111), Expect = 2e-04
Identities = 54/211 (25%), Positives = 80/211 (37%), Gaps = 23/211 (10%)
Query: 458 QYSQTISTKDTRQARG-RSWVMIEPS---GAVQRDQTVLEGGPCQLSCNVKASESPSIFW 513
+Y T+S +QA+ + + I PS G V D +VL +L C + P+I W
Sbjct: 1522 RYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITW 1581
Query: 514 VLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQC-IAQVRDEMDRMVY---- 568
DG P+ I +L I + SDS Y C +A V ++ +
Sbjct: 1582 -YKDGQ----PIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVY 1636
Query: 569 -RVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSH 627
+++ P K V S+TL C A P L+W+ + AN +
Sbjct: 1637 VPPMIEGNLATPLNKQVVI-----AHSLTLECKAAGNPSPILTWLKDG---VPVKANDNI 1688
Query: 628 VYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
L I Q D G Y CVA + G
Sbjct: 1689 RIEAGGKKLEIMSAQEIDRGQYICVATSVAG 1719
Score = 45.1 bits (105), Expect = 0.001
Identities = 45/187 (24%), Positives = 74/187 (39%), Gaps = 15/187 (8%)
Query: 498 QLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLR-IKSMEPSDSGLYQCI 556
+ C K + P+I W L +G L + SIL G L I S+ P D+G Y C+
Sbjct: 1285 EFPCPAKGTPKPTIKW-LHNGRELTGR----EPGISILEDGTLLVIASVTPYDNGEYICV 1339
Query: 557 AQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNR 616
A Y + V P ++ + + L C P + W N
Sbjct: 1340 AVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNV 1399
Query: 617 RIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGAD--HFTVGITV--TKK 671
++ +S + + NG L + + D+G Y C A+N G +F + + V T
Sbjct: 1400 QV----TESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTII 1455
Query: 672 GSGLPSK 678
G+ P++
Sbjct: 1456 GTNFPNE 1462
Score = 37.4 bits (85), Expect = 0.21
Identities = 35/172 (20%), Positives = 63/172 (36%), Gaps = 11/172 (6%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSDSGLYQCIA 557
L C V+ + SP I W + + ++ S +++G L++ P D+G Y C A
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTES------STIQTVNNGKILKLFRATPEDAGRYSCKA 1433
Query: 558 QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRR 617
+ + + V P T + V L C P + W +
Sbjct: 1434 INIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP 1493
Query: 618 IINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
+ +V +L G L + + +D G Y+C N G + +T+
Sbjct: 1494 LF---LGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTI 1542
Score = 32.0 bits (71), Expect = 8.9
Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 9/85 (10%)
Query: 489 QTVLE-GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
+TV+ GG L+C P+I W SI D + ++LS+ L I +
Sbjct: 4448 ETVINAGGKIILNCQATGEPQPTITWSRQGHSI------SWDDRVNVLSNNSLYIADAQK 4501
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLV 572
D+ ++C+A R+ M ++ RV V
Sbjct: 4502 EDTSEFECVA--RNLMGSVLVRVPV 4524
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 309 bits (791), Expect = 3e-83
Identities = 270/973 (27%), Positives = 409/973 (42%), Gaps = 84/973 (8%)
Query: 1860 PQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQ 1919
P +S+T C+A G P+P +TW K Q L+N + R ++
Sbjct: 2220 PTELSLTPGAPMELLCDAQGTPQPNITWHKDG-----------QALTRLENNSRATRVLR 2268
Query: 1920 VQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGD-TIAMECLAKGTP 1978
V+D G Y C A + G + V P I+ V L + +EC + P
Sbjct: 2269 VRDAGLYTCLAESPAGAIEKSFRVRVQAP-PNIVGPRGPRFVVGLAPGQLVLECSVEAEP 2327
Query: 1979 APQISWIFPDRRVWQ----TVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGAD 2034
AP+I+W D V Q T P GR L ++ S +D G Y C A NAAG+
Sbjct: 2328 APKITW-HRDGIVLQEDAHTQFPERGRF-------LQLQALSTADSGDYSCTARNAAGST 2379
Query: 2035 SLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQF 2094
S+A R+ + +P + N+S+ + + C A P P V W D + P
Sbjct: 2380 SVAFRVEIHTVPTIRSGPPAVNVSV--NQTALLPCQADGVPAPLVSW-RKDRVPLDPRS- 2435
Query: 2095 LHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPR 2154
+ P G+L I+ + +D+G Y C+A+N GS R+ L V A A SP
Sbjct: 2436 --PRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIA----PSPS 2489
Query: 2155 RTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDK 2214
+ L C ASG P P ++W +++ L ++ + L++ + +
Sbjct: 2490 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ--GAYRLLPSNALLLTAPGPQ 2547
Query: 2215 DAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPE 2274
D+ + CV N+VG+ + + +V V + P + ++ D V + + C +TG+P P
Sbjct: 2548 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD--DQTDFTVTMMAPVVLTCHSTGIPAPT 2605
Query: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
+SWS L G R Y V +G L + G YTC A N G
Sbjct: 2606 VSWSKAGAQL----------GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2655
Query: 2335 MRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEK 2394
V + V +P V+ + V + CEA G P P +TW V S
Sbjct: 2656 KHVFLTVQASPVV--KPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST- 2712
Query: 2395 YQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVRE 2454
Q+ G L I A D+GNY C+ +NSAG + V V P NG P+ TT
Sbjct: 2713 -QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTE-- 2769
Query: 2455 IAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSV 2514
GS + CKA G P P + W V A + T+ +G L +++L D+
Sbjct: 2770 ----GSHAFLPCKARGSPEPNITWDKDGQPVSGAE---GKFTIQPSGELLVKNLEGQDAG 2822
Query: 2515 QLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSL 2574
C A N G AR + LT+L P+F ++ + G + L C+A G+PTP +
Sbjct: 2823 TYTCTAENAVGRARRRVHLTILV---LPVFTTLPGDRSLRL-GDRLWLRCAARGSPTPRI 2878
Query: 2575 VWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVG 2634
W + N + G Q L + +S D+G Y C A N G T+ + + V
Sbjct: 2879 GWTV-NDRPVTEGVSEQ----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 2933
Query: 2635 LKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNG 2694
P + + + G +++L C G W + +G+ L G + L NG
Sbjct: 2934 EAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHW-IKDGLPLRGSHLRHQ---LQNG 2989
Query: 2695 TLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLN 2754
+LT+R D G Y C E E G + + ++V+ P EP + R G+ V L
Sbjct: 2990 SLTIRRTERDDAGRYQCLAENEMGVA-KKVVILVLQSAPVFQVEPQDMT-VRSGDDVALR 3047
Query: 2755 CMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKN 2814
C A G P I W L+AG R P GSL +++ DAG Y C+A N
Sbjct: 3048 CQATGEPTPTIEW-------LQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHN 3100
Query: 2815 ILGSDSKTTYIHV 2827
+LGS + ++ V
Sbjct: 3101 LLGSATARAFLVV 3113
Score = 295 bits (756), Expect = 3e-79
Identities = 287/986 (29%), Positives = 422/986 (42%), Gaps = 113/986 (11%)
Query: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG-TLVIRKVQ 1919
+ V+V A + C A G P P ++W + G +P+ R+Q VL++G L + +
Sbjct: 1571 EEVTVNASSTVSLQCPALGNPVPTISW--LQNGLPFSPSPRLQ---VLEDGQVLQVSTAE 1625
Query: 1920 VQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPA 1979
V D YMC A N G + L V V P+I + VT L ++++ C P
Sbjct: 1626 VADAASYMCVAENQAGSAEKLFTLRVQVP-PRIAGLDLEQVTAILNSSVSLPCDVHAHPN 1684
Query: 1980 PQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIR 2039
P+++W + D Q +S E L TL + A SD G+Y C A NAAG D ++
Sbjct: 1685 PEVTW-YKDS---QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 1740
Query: 2040 LHVAALPPVIHQEKL---ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI---RPSQ 2093
L V +PP Q + + + G + C A P P+V W DG + + +Q
Sbjct: 1741 LSVL-VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK-DGQPLVLAQRTQ 1798
Query: 2094 FLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSP 2153
L G L I+ D G Y C +N+ G A RT L VQ T +P
Sbjct: 1799 ALRGGQ------RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPP-----TFENP 1847
Query: 2154 RRTDVRY--GGTLKLDCSASGDPWPRILW---RLPSKRMIDALFSFDSRIKVFANGTLVV 2208
+ V G L L C SG P P + W R+P + A+ SR G L +
Sbjct: 1848 KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES--SAVHGVVSR-----GGRLQL 1900
Query: 2209 KSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVAT 2268
+ AG Y CVA N + V V++ P +H V G ++++DC A
Sbjct: 1901 SRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEAD 1960
Query: 2269 GLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAEN 2328
G P P+++W L DGS + D G + Y+ + G+L + + G YTC A N
Sbjct: 1961 GQPPPDVAW-LKDGSPL-----GQDMGPHLRFYL--DGGSLVLKGLRASDAGAYTCVAHN 2012
Query: 2329 QVGKDEMRVRVKVVTAPATIR---NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTN 2385
G+D R+ V P TI+ + + V P G++VT+ C +G P V+WL
Sbjct: 2013 PAGED-ARLHTVNVLVPPTIKQGADGSGTLVSRP-GELVTMVCPVRGSPPIHVSWLK-DG 2069
Query: 2386 KVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKIN-- 2443
+P S TL I K Q +D+G +TC+ + AG + + V V PP +
Sbjct: 2070 LPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV-PPVLEPV 2128
Query: 2444 GNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSL 2503
N + VR GS + C+A G+P P V W +G L + ++ SL
Sbjct: 2129 EFQNDVVVVR-----GSLVELPCEARGVPLPLVSW-MKDGEPLLSQ------SLEQGPSL 2176
Query: 2504 DIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLN 2563
+ ++ DS C+A +E GEAR QLTV+EP P +T G + L
Sbjct: 2177 QLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT--PGAPMELL 2234
Query: 2564 CSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYH--KADGMLHISGLSSVDAGAYRCVARNA 2621
C A GTP P++ W + GQ L R + +A +L + DAG Y C+A +
Sbjct: 2235 CDAQGTPQPNITW-------HKDGQALTRLENNSRATRVLRVR-----DAGLYTCLAESP 2282
Query: 2622 AGHTERLVSLKVGLKPE--ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSW-----TLP 2674
AG E+ ++V P + +V + G+ L L C+ + +W L
Sbjct: 2283 AGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQ 2341
Query: 2675 NGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPR 2734
H + P+ GR L ++ S D G Y C G + + V I P
Sbjct: 2342 EDAHTQFPER-GRF-------LQLQALSTADSGDYSCTARNAAGSTSVAFRV-EIHTVPT 2392
Query: 2735 ITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRF-LHPQG 2793
I S P P + T L C A G+P ++W K V RF + P+G
Sbjct: 2393 IRSGP-PAVNVSVNQTALLPCQADGVPAPLVSWR-------KDRVPLDPRSPRFEILPEG 2444
Query: 2794 SLTIQHATQRDAGFYKCMAKNILGSD 2819
SL IQ +DAG Y C+A N GSD
Sbjct: 2445 SLRIQPVLAQDAGHYLCLASNSAGSD 2470
Score = 285 bits (729), Expect = 4e-76
Identities = 270/935 (28%), Positives = 395/935 (42%), Gaps = 89/935 (9%)
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMEC 1972
L I KV ++D G Y C A+NL G + V L V V P + + V ++ +EC
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLV--PPNIEPGPVNKAVLENASVTLEC 625
Query: 1973 LAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAG 2032
LA G P P +SW + Q VS G + R L I++A SD G Y+CVASN AG
Sbjct: 626 LASGVPPPDVSWF----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 681
Query: 2033 ADSLAIRLHVAALPPVIHQEKLENISLPPGL--------SIHIHCTAKAAPLPSVRWVLG 2084
+ L L V P I+LPP L + + C A AP P++ W L
Sbjct: 682 STELRYGLRVNVPP---------RITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMW-LK 731
Query: 2085 DGTQIRPSQFLHGNLFVFPNG-TLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
DG + P+ L VFP G L + + DSGRY CVA + VG R+ V L V
Sbjct: 732 DGNPVSPAG--TPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPP 789
Query: 2144 ANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILW---RLPSKRMIDALFSFDSRIKV 2200
+ I G V ++ L+C + P P + W P + S D +
Sbjct: 790 S---ILG-EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL-- 843
Query: 2201 FANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGD 2260
L V DAG Y C A N+ G ++V + P +E + V G
Sbjct: 844 -----LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPV-FPLRESHTLTVREGHP 897
Query: 2261 LKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEG 2320
++ C G+P P+ISW DG Q G ++V LY + + +EG
Sbjct: 898 TRLSCECRGVPFPKISWR-KDG-------QPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 949
Query: 2321 DYTCFAENQVGKDEMRVRVKVVTAPATI-RNKTYLAVQVPYGDVVTVACEAKGEPMPKVT 2379
YTC N VG ++++V P + V V V T+ C A G+P P VT
Sbjct: 950 TYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVT 1009
Query: 2380 WLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP 2439
W V + Q Q +L +++AQ + +G Y+C+ N AG + + V V P
Sbjct: 1010 WERDGQPVGAELGLQLQ-NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLV-P 1067
Query: 2440 PKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHG 2499
P++ G+ +P+T + AA S + C+A GIP P + W E V P + + G
Sbjct: 1068 PELIGDLDPLTNI--TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE---DTYLLAG 1122
Query: 2500 NGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHT 2559
L + ++ DS C+A NE GEAR + VL P I ++ + E I + G T
Sbjct: 1123 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP--PSIENEDLEEVIKVLDGQT 1180
Query: 2560 ISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADG-MLHISGLSSVDAGAYRCVA 2618
L C+ G P P L W +G L G + DG +L + + AG Y C+A
Sbjct: 1181 AHLMCNVTGHPQPKLTW-FKDGRPLARG---DAHHISPDGVLLQVLQANLSSAGHYSCIA 1236
Query: 2619 RNAAGHTERLVSLKVGLKPE----ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLP 2674
NA G + L V L P A V++ + L C +W +
Sbjct: 1237 ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW-MK 1295
Query: 2675 NGMHLEGPQTLGRVSLLDNGT--LTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYP 2732
+G E + + LL GT L + A D G Y C + E G +V + V V+ P
Sbjct: 1296 DGAPFEASR---NIQLLP-GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IP 1350
Query: 2733 PRITSEP------TPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGN 2786
P I+ + + T+ +T+ L C + +P I W D + + ++ G
Sbjct: 1351 PSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRW-YKDGQPVTPSSRLQVLGE 1409
Query: 2787 RFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSK 2821
L L IQ D+G Y C+A N+ G D +
Sbjct: 1410 GRL-----LQIQPTQVSDSGRYLCVATNVAGEDDQ 1439
Score = 283 bits (725), Expect = 1e-75
Identities = 266/960 (27%), Positives = 400/960 (41%), Gaps = 91/960 (9%)
Query: 1874 PCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG-TLVIRKVQVQDRGQYMCTASN 1932
PCEA G P P V+W K L + L+ G +L + V D G Y C A +
Sbjct: 2145 PCEARGVPLPLVSWMKDGEPLLS---------QSLEQGPSLQLEAVGAGDSGTYSCVAVS 2195
Query: 1933 LHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAME--CLAKGTPAPQISWIFPDRR 1990
G R L TV +P + Q + L ME C A+GTP P I+W +
Sbjct: 2196 EAGEARRHFQL--TVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQA 2253
Query: 1991 VWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIH 2050
+T EN + + + D G+Y C+A + AGA + R+ V A P ++
Sbjct: 2254 -----------LTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVG 2302
Query: 2051 QEKLENI-SLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRP---SQFLHGNLFVFPNGT 2106
+ L PG + + C+ +A P P + W DG ++ +QF F
Sbjct: 2303 PRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR-DGIVLQEDAHTQFPERGRF------ 2354
Query: 2107 LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKL 2166
L ++ L+ DSG Y C A N GS ++ + + P +V T L
Sbjct: 2355 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPT----IRSGPPAVNVSVNQTALL 2410
Query: 2167 DCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNK 2226
C A G P P + WR L R ++ G+L ++ V +DAG YLC+A N
Sbjct: 2411 PCQADGVPAPLVSWRKDRV----PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2466
Query: 2227 VGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVN 2286
G D + V+ PA I N + L + C A+G P P + W DG ++
Sbjct: 2467 AGSDRQGRDLRVLEPPA-IAPSPSNLTLTAHTPAL-LPCEASGSPKPLVVW-WKDGQKLD 2523
Query: 2287 SFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPA 2346
+Q Y + + L G ++ + C N+VG+ +V V P
Sbjct: 2524 FRLQQG-------AYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2576
Query: 2347 TIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQ 2406
++T V + V+T C + G P P V+W S + Y++ G L I
Sbjct: 2577 IADDQTDFTVTMMAPVVLT--CHSTGIPAPTVSW-SKAGAQLGARGSGYRVSPSGALEIG 2633
Query: 2407 KAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466
+A +G YTC RNSAG K V++ V P + P+ + V E L+ C
Sbjct: 2634 QALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV-VKPLPSVVRAVAE-----EEVLLPC 2687
Query: 2467 KAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGE 2526
+A GIP P + W EG+ + G V G L I D+ +C+A+N G
Sbjct: 2688 EASGIPRPTITWQ-KEGLNVAT---GVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2743
Query: 2527 ARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQS 2586
A +L V P P+ + + + T H L C A G+P P++ W +G +
Sbjct: 2744 AMGKTRLVVQVP---PVIENGLPDLSTTEGSHAF-LPCKARGSPEPNITWD-KDGQPVSG 2798
Query: 2587 GQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNL 2646
+ +F + G L + L DAG Y C A NA G R V L + + P +
Sbjct: 2799 AEG--KFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 2856
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREA-SVFD 2705
S+ G+ L L C G+ R WT+ + EG VS D G+ R A S D
Sbjct: 2857 -SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG------VSEQDGGSTLQRAAVSRED 2909
Query: 2706 RGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADI 2765
GTYVC E G + ++ + + P + E + G +++L+C+ G P DI
Sbjct: 2910 SGTYVCWAENRVGRT-QAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDI 2968
Query: 2766 TWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYI 2825
W +K G+ R R GSLTI+ + DAG Y+C+A+N +G K +
Sbjct: 2969 HW-------IKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVIL 3021
Score = 282 bits (722), Expect = 3e-75
Identities = 257/962 (26%), Positives = 402/962 (41%), Gaps = 91/962 (9%)
Query: 1875 CEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH 1934
C G P V+W K ++ T + TL I KVQ+ D G + C A++
Sbjct: 2053 CPVRGSPPIHVSWLKDGLPLPLSQRTLLHG----SGHTLRISKVQLADAGIFTCVAASPA 2108
Query: 1935 GL-DRMVVLLSVTVQQPQIL--ASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV 1991
G+ DR L VQ P +L DV V G + + C A+G P P +SW+
Sbjct: 2109 GVADRNFTL---QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWM------ 2159
Query: 1992 WQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQ 2051
+ P+ + +L + +L ++ D G Y CVA + AG +L V P +
Sbjct: 2160 -KDGEPLLSQ-SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2217
Query: 2052 EKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRN 2111
+ +SL PG + + C A+ P P++ W DG + + N + R
Sbjct: 2218 GQPTELSLTPGAPMELLCDAQGTPQPNITW-HKDGQALTRLE----------NNSRATRV 2266
Query: 2112 LAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITG-TSPRRTDVRYGGTLKLDCSA 2170
L +D+G Y C+A + G+ ++ ++ VQ A I G PR G L L+CS
Sbjct: 2267 LRVRDAGLYTCLAESPAGAIEKSFRVRVQ---APPNIVGPRGPRFVVGLAPGQLVLECSV 2323
Query: 2171 SGDPWPRILW-RLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD 2229
+P P+I W R DA F R + L +++++ D+GDY C ARN G
Sbjct: 2324 EAEPAPKITWHRDGIVLQEDAHTQFPERGRF-----LQLQALSTADSGDYSCTARNAAGS 2378
Query: 2230 DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFM 2289
V +V++ P V + C A G+P P +SW L
Sbjct: 2379 TSVAFRVEIHTVPT--IRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPL----- 2431
Query: 2290 QSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIR 2349
R+ R+ + G+L V ++ G Y C A N G D ++V+ PA
Sbjct: 2432 -----DPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAP 2486
Query: 2350 NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKV-IPTSSEKYQIYQDGTLLIQKA 2408
+ + L + + CEA G P P V W K+ Y++ LL+
Sbjct: 2487 SPSNLTLTA--HTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAP 2544
Query: 2409 QRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKA 2468
DS + C+V N GE + + V+V PP I + T ++ C +
Sbjct: 2545 GPQDSAQFECVVSNEVGEAHRLYQVTVHV-PPTIADDQTDFTVTMMAPV-----VLTCHS 2598
Query: 2469 EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEAR 2528
GIP P V W+ G L A G R++ +G+L+I + + C ARN G A
Sbjct: 2599 TGIPAPTVSWS-KAGAQLGARGSGYRVS--PSGALEIGQALPIHAGRYTCSARNSAGVAH 2655
Query: 2529 LILQLTV-LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSG 2587
+ LTV P+ K P+ + A+A + L C A+G P P++ W G ++ +G
Sbjct: 2656 KHVFLTVQASPVVK-----PLPSVVRAVAEEEVLLPCEASGIPRPTITW-QKEGLNVATG 2709
Query: 2588 QQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLV 2647
Q G L I+ S DAG Y C+A+N+AG L V + P +L
Sbjct: 2710 VSTQVL---PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDL- 2765
Query: 2648 SIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRG 2707
S G LPC G+ + +W +G + G + G+ ++ +G L V+ D G
Sbjct: 2766 STTEGSHAFLPCKARGSPEPNITWD-KDGQPVSGAE--GKFTIQPSGELLVKNLEGQDAG 2822
Query: 2708 TYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITW 2767
TY C E G + + + ++ P T + R G+ + L C A G P I W
Sbjct: 2823 TYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL--RLGDRLWLRCAARGSPTPRIGW 2880
Query: 2768 ELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHA--TQRDAGFYKCMAKNILGSDSKTTYI 2825
+ D+ + GV + G T+Q A ++ D+G Y C A+N +G +++
Sbjct: 2881 TVNDRP-VTEGVSEQ---------DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 2930
Query: 2826 HV 2827
HV
Sbjct: 2931 HV 2932
Score = 272 bits (695), Expect = 4e-72
Identities = 231/809 (28%), Positives = 359/809 (44%), Gaps = 83/809 (10%)
Query: 1856 LTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVI 1915
+ P V+V+ + PC+A G P P V+W K + + R RFE+L G+L I
Sbjct: 2393 IRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK----DRVPLDPRSPRFEILPEGSLRI 2448
Query: 1916 RKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAK 1975
+ V QD G Y+C ASN G DR + V +P +A ++T+ + C A
Sbjct: 2449 QPVLAQDAGHYLCLASNSAGSDRQG--RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 2506
Query: 1976 GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS 2035
G+P P + W +++ + +G L + L + D ++CV SN G
Sbjct: 2507 GSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE-- 2562
Query: 2036 LAIRLH--VAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI--RP 2091
A RL+ +PP I ++ + ++ + + C + P P+V W G Q+ R
Sbjct: 2563 -AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVVLTCHSTGIPAPTVSWSKA-GAQLGARG 2619
Query: 2092 SQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGT 2151
S + V P+G L I P +GRY C A N G A + V L VQ + +
Sbjct: 2620 SGYR-----VSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP----VVKP 2670
Query: 2152 SPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSV 2211
P + L C ASG P P I W+ + + + +V G L +
Sbjct: 2671 LPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQLRIAHA 2725
Query: 2212 TDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLP 2271
+ +DAG+YLC+A+N G ++ VV P IE+ D G + C A G P
Sbjct: 2726 SPEDAGNYLCIAKNSAGSAMGKTRL-VVQVPPVIENGLP-DLSTTEGSHAFLPCKARGSP 2783
Query: 2272 NPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG 2331
P I+W DG V+ G ++ + +G L + ++ G YTC AEN VG
Sbjct: 2784 EPNITWD-KDGQPVS---------GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG 2833
Query: 2332 KDEMRVRVKVVTAP--ATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIP 2389
+ RV + ++ P T+ L + GD + + C A+G P P++ W V
Sbjct: 2834 RARRRVHLTILVLPVFTTLPGDRSLRL----GDRLWLRCAARGSPTPRIGWTVNDRPVTE 2889
Query: 2390 TSSEKYQIYQDGTLLIQKA--QRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPN 2447
SE QDG +Q+A R DSG Y C N G + ++HV + P + G
Sbjct: 2890 GVSE-----QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK-EAPVLQGEAF 2943
Query: 2448 PITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRS 2507
GGS +L DC G P P + W +G+ L + +++ NGSL IR
Sbjct: 2944 SYLVE---PVGGSIQL-DCVVRGDPVPDIHW-IKDGLPLRGSHLRHQLQ---NGSLTIRR 2995
Query: 2508 LRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH-DPISEKITAMAGHTISLNCSA 2566
+ D+ + C+A NE G A+ ++ +L P+F +P + +T +G ++L C A
Sbjct: 2996 TERDDAGRYQCLAENEMGVAK---KVVILVLQSAPVFQVEP--QDMTVRSGDDVALRCQA 3050
Query: 2567 AGTPTPSLVWVLPNGTDLQSGQQL---QRFYHKADGMLHISGLSSVDAGAYRCVARNAAG 2623
G PTP++ W LQ+GQ L +R DG L + + + DAG Y CVA N G
Sbjct: 3051 TGEPTPTIEW-------LQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLG 3103
Query: 2624 HTERLVSLKVGLKPEANKQYHNLVSIING 2652
L V +P+ + + ++ +ING
Sbjct: 3104 SATARAFLVVRGEPQGS--WGSMTGVING 3130
Score = 268 bits (684), Expect = 7e-71
Identities = 265/1013 (26%), Positives = 414/1013 (40%), Gaps = 93/1013 (9%)
Query: 1853 PQILTKSPQTVSVTA--ETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
P+++ ++TA + CEA G P P + W + +T + L
Sbjct: 1068 PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYL-----LAG 1122
Query: 1911 GTLV-IRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYL-GDTI 1968
G ++ + + Q QD G Y C ASN G R + V V P I ++V L G T
Sbjct: 1123 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP-PSIENEDLEEVIKVLDGQTA 1181
Query: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS 2028
+ C G P P+++W F D R ++ + + L + +A+ S G Y C+A+
Sbjct: 1182 HLMCNVTGHPQPKLTW-FKDGR---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAA 1237
Query: 2029 NAAGADSLAIRLHVAALPPVI---HQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD 2085
NA G + +L V P ++ E +++ I + C A A P P++ W + D
Sbjct: 1238 NAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW-MKD 1296
Query: 2086 GTQIRPSQFLHGNLFVFPNGT--LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
G S+ N+ + P GT L I N +D+G+Y CV N +G A + + V
Sbjct: 1297 GAPFEASR----NIQLLP-GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 1351
Query: 2144 ANAR---ITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV 2200
+ ++ + + + TL L+C + P P I W + + + SR++V
Sbjct: 1352 SISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS-----SRLQV 1406
Query: 2201 FANGTLV-VKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPA-----------KIEHK 2248
G L+ ++ D+G YLCVA N G+D V + + P +I +
Sbjct: 1407 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSR 1466
Query: 2249 EENDH-------KVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
EE ++ + C +P P+++W D L S GGR
Sbjct: 1467 EEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRV--- 1523
Query: 2302 VVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA--VQVP 2359
L V G Y+C A N+VG+D + + V+T P + + L V V
Sbjct: 1524 -------LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVN 1576
Query: 2360 YGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTC 2418
V++ C A G P+P ++WL N + + S + Q+ +DG +L + A+ +D+ +Y C
Sbjct: 1577 ASSTVSLQCPALGNPVPTISWLQ--NGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMC 1634
Query: 2419 LVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLW 2478
+ N AG K + V V PP+I G + + A S + C P P V W
Sbjct: 1635 VAENQAGSAEKLFTLRVQV-PPRIAG----LDLEQVTAILNSSVSLPCDVHAHPNPEVTW 1689
Query: 2479 AFPEGVVLPAPYYGNRI-TVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLE 2537
+ + L G + + G +L + R SDS C A N G + ++QL+VL
Sbjct: 1690 -YKDSQALSL---GEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1745
Query: 2538 PMEKPIFHDPI---SEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFY 2594
P P F + + G L+C P P++ W +G L Q+ Q
Sbjct: 1746 P---PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWY-KDGQPLVLAQRTQAL- 1800
Query: 2595 HKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGET 2654
+ L I D G Y C N AG R +L V + P VS + G
Sbjct: 1801 -RGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSP 1859
Query: 2655 LKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRME 2714
L L C G +W L + M +E G VS G L + GTY C E
Sbjct: 1860 LVLTCDVSGVPAPTVTW-LKDRMPVESSAVHGVVSR--GGRLQLSRLQPAQAGTYTCVAE 1916
Query: 2715 TEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSH 2774
+ V V+ P +S + G V+L+C A G P D+ W L D S
Sbjct: 1917 NTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW-LKDGSP 1975
Query: 2775 LKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
L + L RF GSL ++ DAG Y C+A N G D++ ++V
Sbjct: 1976 LGQDMGPHL---RFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNV 2025
Score = 263 bits (673), Expect = 1e-69
Identities = 263/1011 (26%), Positives = 404/1011 (39%), Gaps = 116/1011 (11%)
Query: 1853 PQIL--TKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
PQI + P VSV + C ATGKP P VTW + ++Q +
Sbjct: 974 PQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN----QG 1029
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILAS--HYQDVTVYLGDTI 1968
+L + + Q G+Y C A NL G LSV V P+++ ++T L +
Sbjct: 1030 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVP-PELIGDLDPLTNITAALHSPL 1088
Query: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS 2028
+ C A G P P I W R + VSP E L L + + D G+Y C+AS
Sbjct: 1089 TLLCEAMGIPPPAIRWF----RGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 1144
Query: 2029 NAAGADSLAIRLHVAALPPVIHQEKLEN-ISLPPGLSIHIHCTAKAAPLPSVRWVLGDGT 2087
N AG + V +PP I E LE I + G + H+ C P P + W DG
Sbjct: 1145 NEAGEARRNFSVEV-LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTW-FKDGR 1202
Query: 2088 QIRPSQFLHGNLFVFPNGT-LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANA 2146
+ H + P+G L + +G Y C+AAN VG + QL+V A
Sbjct: 1203 PLARGDAHH----ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT-- 1256
Query: 2147 RITGTSPRRTD----VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFA 2202
I G + D V + L C A P P I W M D SR
Sbjct: 1257 -ILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW------MKDGAPFEASRNIQLL 1309
Query: 2203 NGT--LVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPA-----KIEHKEENDHKV 2255
GT L + + +DAG Y CV N++G+ V+V++ P+ + + K
Sbjct: 1310 PGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKT 1369
Query: 2256 FYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG-TLYFNEV 2314
L ++C + +P P I W DG V + R V G L
Sbjct: 1370 KVNSTLTLECESWAVPPPTIRW-YKDGQPVTP----------SSRLQVLGEGRLLQIQPT 1418
Query: 2315 GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAV-------------QVPYG 2361
+ + G Y C A N G+D+ V + P + + A Y
Sbjct: 1419 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1478
Query: 2362 DVVT-----VACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGN 2415
++V + C+ P P +TW + ++ ++ + Q G +L I + ++G
Sbjct: 1479 EIVENNPAYLYCDTNAIPPPDLTWYREDQPL--SAGDEVSVLQGGRVLQIPLVRAENAGR 1536
Query: 2416 YTCLVRNSAGEDRKTVWIHVN---VQPPKINGNPNPITTVREIAAGGSRKL-IDCKAEGI 2471
Y+C N GED W+H + PP I G+ + V E+ S + + C A G
Sbjct: 1537 YSCKASNEVGED----WLHYELLVLTPPVILGDTEEL--VEEVTVNASSTVSLQCPALGN 1590
Query: 2472 PTPRVLWAFPEGVVLPAPYYGNRITVHGNGS-LDIRSLRKSDSVQLVCMARNEGGEARLI 2530
P P + W P+P R+ V +G L + + +D+ +C+A N+ G A +
Sbjct: 1591 PVPTISWLQNGLPFSPSP----RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKL 1646
Query: 2531 LQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQL 2590
L V P P E++TA+ ++SL C P P + W + L G+++
Sbjct: 1647 FTLRVQVP---PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTW-YKDSQALSLGEEV 1702
Query: 2591 QRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP---EANKQYHNLV 2647
F L + D+G Y C A NAAG ++LV L V + P +A + + V
Sbjct: 1703 --FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAV 1760
Query: 2648 SIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNG-TLTVREASVFDR 2706
+ G+ L C + +W +G L Q R L G L ++EA V D+
Sbjct: 1761 LVRVGDKAVLSCETDALPEPTVTW-YKDGQPLVLAQ---RTQALRGGQRLEIQEAQVSDK 1816
Query: 2707 GTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADIT 2766
G Y C++ G +V + + + PP + T + G+ + L C G+P +T
Sbjct: 1817 GLYSCKVSNVAGEAVRTF-TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVT 1875
Query: 2767 W---ELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKN 2814
W +P +S GV +R G L + AG Y C+A+N
Sbjct: 1876 WLKDRMPVESSAVHGVVSR---------GGRLQLSRLQPAQAGTYTCVAEN 1917
Score = 247 bits (630), Expect = 1e-64
Identities = 258/1018 (25%), Positives = 416/1018 (40%), Gaps = 86/1018 (8%)
Query: 1836 FFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFP--CEATGKPKPFVTWTKVSTG 1893
F G A F P + S +T V D + CEA G P P +TW K G
Sbjct: 201 FSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFK--DG 258
Query: 1894 ALMTPNTRIQRFEVLKNG--TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQ 1951
AL+ +T++ V G L + + Q D G Y C ASN G L V V P
Sbjct: 259 ALLPTSTKV----VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVP-PT 313
Query: 1952 ILASHYQDVTV--YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRT 2009
I + + V G +A+EC+A+G P+P +SW V ++ E R+ +
Sbjct: 314 IEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESN---ESRLET-DGSV 369
Query: 2010 LSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHC 2069
L ++ + G+Y CVAS+ AG L + V P ++ E L ++ G + + C
Sbjct: 370 LRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 429
Query: 2070 TAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVG 2129
A +P+P+++W+ RP++ L G TL+I ++ SG + C A N G
Sbjct: 430 QASGSPVPTIQWLQNG----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 485
Query: 2130 SARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRL-PSKRMI 2188
+A V+++V A + + +G A+ DP W P ++
Sbjct: 486 TAGAEVEVSVHGEWAPGVLEVPIGQ---YHWGXEHHSSFPAACDPPVHRGWGAHPKPPLV 542
Query: 2189 D------ALFSFDSRIKVFAN--GTLVVKSVTDKDAGDYLCVARNKVGDD--YVVLKVDV 2238
+ +L+ + I V + L ++ V +D G Y C A N G+ V LK
Sbjct: 543 EGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK--- 599
Query: 2239 VMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRT 2298
V+ P IE N V + ++C+A+G+P P++SW V+S+M G T
Sbjct: 600 VLVPPNIEPGPVN-KAVLENASVTLECLASGVPPPDVSW-FKGHQPVSSWM------GVT 651
Query: 2299 KRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQV 2358
V + L + + + G Y C A N G E+R ++ V P I L V
Sbjct: 652 ---VSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLR-VNVPPRITLPPSLPGPV 707
Query: 2359 PYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYT 2417
V + C A G P P + WL N V P + Q++ G +L + A+ SDSG Y+
Sbjct: 708 LVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYS 767
Query: 2418 CLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVL 2477
C+ ++ GEDR+ V + V++ PP I G ++ V + ++C++ +P P +
Sbjct: 768 CVAVSAVGEDRQDVVLQVHM-PPSILGEELNVSVVANESVA-----LECQSHAMPPPVLS 821
Query: 2478 WAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLE 2537
W + P P G ++ L + D+ C A N+ G + L V
Sbjct: 822 WWKDGRPLEPRP--GVHLSA-DKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV-- 876
Query: 2538 PMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKA 2597
P+F S +T GH L+C G P P + W +G L +
Sbjct: 877 -WVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISW-RKDGQPLPGEGAGLQHVSAV 934
Query: 2598 DGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPE--ANKQYHNLVSIINGETL 2655
+L++ G Y C N G++ + + L+V + P+ ++ VS++
Sbjct: 935 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA 994
Query: 2656 KLPCTPPGAGQGRFSWT---LPNGMHLEGPQTLGRVSLLDNG-TLTVREASVFDRGTYVC 2711
L C G +W P G L + L + G +L V A G Y C
Sbjct: 995 TLECNATGKPPPTVTWERDGQPVGAEL-------GLQLQNQGQSLHVERAQAAHTGRYSC 1047
Query: 2712 RMETEYGPSVTSIPVIVIAYPPRITSEPTPV--IYTRPGNTVKLNCMAMGIPKADITWEL 2769
E G + + V+ PP + + P+ I + + L C AMGIP I W
Sbjct: 1048 VAENLAGRAERKFELSVLV-PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW-F 1105
Query: 2770 PDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ + G L ++ L + ++D+G Y C+A N G + + V
Sbjct: 1106 RGEEPVSPGEDTYLLAGGWM-----LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1158
Score = 246 bits (627), Expect = 3e-64
Identities = 235/910 (25%), Positives = 368/910 (40%), Gaps = 79/910 (8%)
Query: 1858 KSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRK 1917
+ P+ V A V C +P P +TW + G ++ + Q E + L ++
Sbjct: 2304 RGPRFVVGLAPGQLVLECSVEAEPAPKITWHR--DGIVLQEDAHTQFPE--RGRFLQLQA 2359
Query: 1918 VQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGT 1977
+ D G Y CTA N G V V + + S V V + T + C A G
Sbjct: 2360 LSTADSGDYSCTARNAAGSTS--VAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 2417
Query: 1978 PAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLA 2037
PAP +SW R+ + P R + +L I+ D G Y C+ASN+AG+D
Sbjct: 2418 PAPLVSW----RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQG 2473
Query: 2038 IRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHG 2097
L V PP I N++L + C A +P P V W DG ++ + G
Sbjct: 2474 RDLRVLE-PPAIAPSP-SNLTLTAHTPALLPCEASGSPKPLVVW-WKDGQKL-DFRLQQG 2529
Query: 2098 NLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTD 2157
+ P+ L + P+DS ++ECV +N VG A R Q+ V A +TD
Sbjct: 2530 AYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIA------DDQTD 2583
Query: 2158 --VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKD 2215
V + L C ++G P P + W + L + S +V +G L +
Sbjct: 2584 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ----LGARGSGYRVSPSGALEIGQALPIH 2639
Query: 2216 AGDYLCVARNKVG----DDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLP 2271
AG Y C ARN G ++ ++ V+KP + + +V + C A+G+P
Sbjct: 2640 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVL------LPCEASGIP 2693
Query: 2272 NPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG 2331
P I+W +G V + + + V G L + G+Y C A+N G
Sbjct: 2694 RPTITWQ-KEGLNVATGVSTQ----------VLPGGQLRIAHASPEDAGNYLCIAKNSAG 2742
Query: 2332 KDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTS 2391
+ R+ VV P I N + G + C+A+G P P +TW + + +
Sbjct: 2743 SAMGKTRL-VVQVPPVIENGLP-DLSTTEGSHAFLPCKARGSPEPNITW-DKDGQPVSGA 2799
Query: 2392 SEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITT 2451
K+ I G LL++ + D+G YTC N+ G R+ V + + V P TT
Sbjct: 2800 EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPV--------FTT 2851
Query: 2452 V---REIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSL 2508
+ R + G R + C A G PTPR+ W V P G +L ++
Sbjct: 2852 LPGDRSLRLG-DRLWLRCAARGSPTPRIGWT-----VNDRPVTEGVSEQDGGSTLQRAAV 2905
Query: 2509 RKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAG 2568
+ DS VC A N G + + + + E P+ + G +I L+C G
Sbjct: 2906 SREDSGTYVCWAENRVGRTQAV---SFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRG 2962
Query: 2569 TPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERL 2628
P P + W+ +G L+ G L+ + +G L I DAG Y+C+A N G +++
Sbjct: 2963 DPVPDIHWI-KDGLPLR-GSHLR--HQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKV 3018
Query: 2629 VSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRV 2688
V L + P + ++ ++ +G+ + L C G W L G L + R+
Sbjct: 3019 VILVLQSAPVFQVEPQDM-TVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRASR---RL 3073
Query: 2689 SLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPG 2748
L +G+L + D GTY C G + ++V P T VI R
Sbjct: 3074 RTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKF 3133
Query: 2749 NTVKLNCMAM 2758
LN M
Sbjct: 3134 GVATLNTSVM 3143
Score = 244 bits (624), Expect = 7e-64
Identities = 268/982 (27%), Positives = 402/982 (40%), Gaps = 86/982 (8%)
Query: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALM-TPNTRIQRFEVLKNGTLVIRKVQ 1919
Q V A D C +G P P V WTK L P+ ++Q L I
Sbjct: 134 QEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQE----DGQVLRITGSH 189
Query: 1920 VQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPA 1979
V D G+Y C A + G L V ++ +V V + + C A+G P
Sbjct: 190 VGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPT 249
Query: 1980 PQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIR 2039
P I+W F D + T + V + R L + A SD GVY C ASNA GA A R
Sbjct: 250 PNITW-FKDGALLPTSTKV---VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATR 305
Query: 2040 LHVAALPPVIHQE--KLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHG 2097
L V +PP I + + G + + C A+ P P++ W +G + S +
Sbjct: 306 LDV-YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW-HHEGLPVAES---NE 360
Query: 2098 NLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTD 2157
+ L + + SG Y CVA++ G A +Q +V+ + +
Sbjct: 361 SRLETDGSVLRLESPGEASSGLYSCVASSPAGEA--VLQYSVEVQVPPQLLVAEGLGQVT 418
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANG-TLVVKSVTDKDA 2216
G L+L C ASG P P I W L + R + L + ++V + G TL + V +
Sbjct: 419 TIVGQPLELPCQASGSPVPTIQW-LQNGRPAEEL----AGVQVASQGTTLHIDHVELDHS 473
Query: 2217 GDYLCVARNKVGDDYVVLKVDV--VMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPE 2274
G + C A N+ G ++V V P +E H +G + A P
Sbjct: 474 GLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYH---WGXEHHSSFPAACDPPVH 530
Query: 2275 ISWSL-PDGSLVNSFMQSDDSGGRTKRYVVFNN--GTLYFNEVGMREEGDYTCFAENQVG 2331
W P LV + G V + L +V +R+EG YTC A N G
Sbjct: 531 RGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 590
Query: 2332 KDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTS 2391
+ + V +KV+ P AV VT+ C A G P P V+W V +S
Sbjct: 591 ESKREVALKVLVPPNIEPGPVNKAVL--ENASVTLECLASGVPPPDVSWFKGHQPV--SS 646
Query: 2392 SEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKIN---GNPN 2447
+ DG +L I++AQ SD+G+Y C+ N AG + VNV PP+I P
Sbjct: 647 WMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV-PPRITLPPSLPG 705
Query: 2448 PI---TTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLD 2504
P+ T VR + C A G P+P ++W V PA G ++ G L
Sbjct: 706 PVLVNTPVR----------LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV-FPGGRVLT 754
Query: 2505 IRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNC 2564
+ S R SDS + C+A + GE R + L V M I + ++ ++ +A +++L C
Sbjct: 755 LASARASDSGRYSCVAVSAVGEDRQDVVLQV--HMPPSILGEELN--VSVVANESVALEC 810
Query: 2565 SAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGH 2624
+ P P L W +G L+ + KA +L + DAG Y C A N AGH
Sbjct: 811 QSHAMPPPVLSW-WKDGRPLEPRPGVHLSADKA--LLQVDRADVWDAGHYTCEALNQAGH 867
Query: 2625 TERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSW-----TLP-NGMH 2678
+E+ +L V + P + + +++ G +L C G + SW LP G
Sbjct: 868 SEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAG 927
Query: 2679 LEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITS- 2737
L+ +GR+ L + +A + GTY C G S + + + PP+I
Sbjct: 928 LQHVSAVGRL-------LYLGQAQLAQEGTYTCECSNVVGNSSQDLQ-LEVHVPPQIAGP 979
Query: 2738 -EPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKS-HLKAGVQARLYGNRFLHPQGSL 2795
EP + L C A G P +TWE + + G+Q + G SL
Sbjct: 980 REPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ-------SL 1032
Query: 2796 TIQHATQRDAGFYKCMAKNILG 2817
++ A G Y C+A+N+ G
Sbjct: 1033 HVERAQAAHTGRYSCVAENLAG 1054
Score = 240 bits (613), Expect = 1e-62
Identities = 279/1086 (25%), Positives = 414/1086 (38%), Gaps = 125/1086 (11%)
Query: 1785 PAPPLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPAS 1844
P PPL+ + GS IP+ S + ++ G + +++ AG
Sbjct: 537 PKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNL-AGESKRE 595
Query: 1845 KFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTK----VST--GALMTP 1898
+ P I P +V C A+G P P V+W K VS+ G ++
Sbjct: 596 VALKVLVPPNI-EPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV 654
Query: 1899 NTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQ 1958
+ R+ R E + Q+ D G Y C ASN+ G + L V V P+I
Sbjct: 655 DGRVLRIE----------QAQLSDAGSYRCVASNVAGSTELRYGLRVNV-PPRITLPPSL 703
Query: 1959 DVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFS 2018
V + + + C A G P+P + W+ V +P G R L++ A S
Sbjct: 704 PGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTP--GLQVFPGGRVLTLASARAS 761
Query: 2019 DRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPS 2078
D G Y CVA +A G D + L V +PP I E+L N+S+ S+ + C + A P P
Sbjct: 762 DSGRYSCVAVSAVGEDRQDVVLQV-HMPPSILGEEL-NVSVVANESVALECQSHAMPPPV 819
Query: 2079 VRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLN 2138
+ W DG + P +H L + D+G Y C A N G + + LN
Sbjct: 820 LSW-WKDGRPLEPRPGVH---LSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLN 875
Query: 2139 VQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR-----LPSKRMIDALFS 2193
V A VR G +L C G P+P+I WR LP + S
Sbjct: 876 VWVAPV---FPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVS 932
Query: 2194 FDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKE-END 2252
R+ L G Y C N VG+ L+++V + P +E
Sbjct: 933 AVGRLLYLGQAQLA-------QEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQ 985
Query: 2253 HKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFN 2312
V G ++C ATG P P ++W DG V G + +L+
Sbjct: 986 VSVVQDGVATLECNATGKPPPTVTWE-RDGQPV---------GAELGLQLQNQGQSLHVE 1035
Query: 2313 EVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA-VQVPYGDVVTVACEAK 2371
G Y+C AEN G+ E + + V+ P I + L + +T+ CEA
Sbjct: 1036 RAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAM 1095
Query: 2372 GEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTV 2431
G P P + W V P + Y + L + + Q DSG Y+CL N AGE R+
Sbjct: 1096 GIPPPAIRWFRGEEPVSP-GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNF 1154
Query: 2432 WIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYY 2491
+ V V P N + + V + G + C G P P++ W F +G L
Sbjct: 1155 SVEVLVPPSIENEDLEEVIKVLD----GQTAHLMCNVTGHPQPKLTW-FKDGRPLAR--- 1206
Query: 2492 GNRITVHGNG-SLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV-LEPMEKPIFHDPIS 2549
G+ + +G L + S + C+A N GE QL+V L P D
Sbjct: 1207 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 1266
Query: 2550 EKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSV 2609
E++T + ISL C A P+P++ W + +G ++ + +Q L I
Sbjct: 1267 EEVTVTVNNPISLICEALAFPSPNITW-MKDGAPFEASRNIQLL--PGTHGLQILNAQKE 1323
Query: 2610 DAGAYRCVARNAAGHTERLVSLKVGLKPEANKQ-------YHNLVSIINGETLKLPCTPP 2662
DAG Y CV N G + ++V + P +K + + +N TL L C
Sbjct: 1324 DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN-STLTLECE-- 1380
Query: 2663 GAGQGRFSWTLPN---GMHLEG-PQT-LGRVSLLDNG-TLTVREASVFDRGTYVCRMETE 2716
SW +P + +G P T R+ +L G L ++ V D G Y+C
Sbjct: 1381 -------SWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 1433
Query: 2717 YGPSVTSIPVIVIAYPPRI----------------------TSEPTPVIYTRPGNTVKLN 2754
G V+ I PP +E ++ P L
Sbjct: 1434 AGEDDQDFNVL-IQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNP---AYLY 1489
Query: 2755 CMAMGIPKADITWELPDKSHLKAGVQAR-LYGNRFLHPQGSLTIQHATQRDAGFYKCMAK 2813
C IP D+TW D+ L AG + L G R L I +AG Y C A
Sbjct: 1490 CDTNAIPPPDLTWYREDQP-LSAGDEVSVLQGGRVLQ------IPLVRAENAGRYSCKAS 1542
Query: 2814 NILGSD 2819
N +G D
Sbjct: 1543 NEVGED 1548
Score = 230 bits (586), Expect = 2e-59
Identities = 190/682 (27%), Positives = 293/682 (42%), Gaps = 62/682 (9%)
Query: 1852 KPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG 1911
+P + SP +++TA T + PCEA+G PKP V W K G + + + +L +
Sbjct: 2480 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK--DGQKLDFRLQQGAYRLLPSN 2537
Query: 1912 TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAME 1971
L++ QD Q+ C SN G L VTV P +A D TV + + +
Sbjct: 2538 ALLLTAPGPQDSAQFECVVSNEVGEAHR--LYQVTVHVPPTIADDQTDFTVTMMAPVVLT 2595
Query: 1972 CLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAA 2031
C + G PAP +SW + + + + L I +A G Y C A N+A
Sbjct: 2596 CHSTGIPAPTVSW----SKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 2651
Query: 2032 GADSLAIRLHVAA------LPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD 2085
G + L V A LP V+ E + LP C A P P++ W +
Sbjct: 2652 GVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLP--------CEASGIPRPTITW-QKE 2702
Query: 2086 GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAAN 2145
G + + V P G L I + +P+D+G Y C+A N GSA +L VQ
Sbjct: 2703 GLNVATGV----STQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV- 2757
Query: 2146 ARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGT 2205
I P + G L C A G P P I W + + A + + + +G
Sbjct: 2758 --IENGLPDLSTTE-GSHAFLPCKARGSPEPNITWDKDGQPVSGA----EGKFTIQPSGE 2810
Query: 2206 LVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDC 2265
L+VK++ +DAG Y C A N VG + + +++ P + D + G L + C
Sbjct: 2811 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP--VFTTLPGDRSLRLGDRLWLRC 2868
Query: 2266 VATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCF 2325
A G P P I W++ D + + D GG TL V + G Y C+
Sbjct: 2869 AARGSPTPRIGWTVNDRPVTEGVSEQD--GG----------STLQRAAVSREDSGTYVCW 2916
Query: 2326 AENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTN 2385
AEN+VG+ + V V AP ++ + + + P G + + C +G+P+P + W+
Sbjct: 2917 AENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIK-DG 2974
Query: 2386 KVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGN 2445
+ S ++Q+ Q+G+L I++ +R D+G Y CL N G +K V I V P
Sbjct: 2975 LPLRGSHLRHQL-QNGSLTIRRTERDDAGRYQCLAENEMGVAKKVV-ILVLQSAPVFQVE 3032
Query: 2446 PNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDI 2505
P +T G + C+A G PTP + W G L A R+ +GSL +
Sbjct: 3033 PQDMT-----VRSGDDVALRCQATGEPTPTIEW-LQAGQPLRA---SRRLRTLPDGSLWL 3083
Query: 2506 RSLRKSDSVQLVCMARNEGGEA 2527
++ D+ C+A N G A
Sbjct: 3084 ENVETGDAGTYDCVAHNLLGSA 3105
Score = 228 bits (581), Expect = 6e-59
Identities = 254/1002 (25%), Positives = 399/1002 (39%), Gaps = 96/1002 (9%)
Query: 1863 VSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNT----------RIQRFEVLKNG- 1911
VS A C+A G P P + W K + + ++ +L G
Sbjct: 28 VSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ 87
Query: 1912 TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAME 1971
+L ++Q D G Y C A N G + L V + A Q+V G + ++
Sbjct: 88 SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQ 147
Query: 1972 CLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHEN-RTLSIKEASFSDRGVYKCVASNA 2030
C G P PQ+ W DR Q V P + + E+ + L I + D G Y+CVA +
Sbjct: 148 CWTSGVPTPQVEWT-KDR---QPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP 203
Query: 2031 AGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIR 2090
AG + +L V A P + + +++ + + C A+ P P++ W DG +
Sbjct: 204 AGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW-FKDGALLP 262
Query: 2091 PSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITG 2150
S + ++ L + D+G Y C A+N VG+A + +L+V G
Sbjct: 263 TSTKV---VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEGAG 318
Query: 2151 TSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKS 2210
P G + L+C A G P P + W + + S +SR++ L ++S
Sbjct: 319 GRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAE---SNESRLET-DGSVLRLES 374
Query: 2211 VTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGL 2270
+ +G Y CVA + G+ + V+V + P + + G L++ C A+G
Sbjct: 375 PGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGS 434
Query: 2271 PNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQV 2330
P P I W L N + +G + V TL+ + V + G + C A N+
Sbjct: 435 PVPTIQW------LQNGRPAEELAGVQ----VASQGTTLHIDHVELDHSGLFACQATNEA 484
Query: 2331 GK--DEMRVRVKVVTAPATIRNKTYLAVQVPYGDV---------VTVACEAK------GE 2373
G E+ V V AP + +VP G AC+
Sbjct: 485 GTAGAEVEVSVHGEWAPGVL--------EVPIGQYHWGXEHHSSFPAACDPPVHRGWGAH 536
Query: 2374 PMPKVT--WLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTV 2431
P P + W SP + + L I+K D G YTC N AGE ++ V
Sbjct: 537 PKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREV 596
Query: 2432 WIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYY 2491
+ V V PP I P V + + ++C A G+P P V W +G + +
Sbjct: 597 ALKVLV-PPNIEPGP-----VNKAVLENASVTLECLASGVPPPDVSWF--KGHQPVSSWM 648
Query: 2492 GNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEK 2551
G ++V G L I + SD+ C+A N G L L V P P P S
Sbjct: 649 GVTVSVDGR-VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVP---PRITLPPSLP 704
Query: 2552 ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQ-LQRFYHKADGMLHISGLSSVD 2610
+ + L C+A G P+P+L+W+ +G LQ F +L ++ + D
Sbjct: 705 GPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVF--PGGRVLTLASARASD 762
Query: 2611 AGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFS 2670
+G Y CVA +A G + V L+V + P + N VS++ E++ L C S
Sbjct: 763 SGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELN-VSVVANESVALECQSHAMPPPVLS 821
Query: 2671 WTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIA 2730
W +G LE P+ +S D L V A V+D G Y C + G S + V
Sbjct: 822 W-WKDGRPLE-PRPGVHLS-ADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWV 878
Query: 2731 YPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWE-----LPDKSHLKAGVQARLYG 2785
P E + + R G+ +L+C G+P I+W LP + AG+Q
Sbjct: 879 APVFPLRE-SHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEG---AGLQHVSAV 934
Query: 2786 NRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
R L+ + A G Y C N++G+ S+ + V
Sbjct: 935 GRLLY------LGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 970
Score = 199 bits (507), Expect = 2e-50
Identities = 232/910 (25%), Positives = 341/910 (37%), Gaps = 99/910 (10%)
Query: 1959 DVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVS-----------PVEGRITLHEN 2007
+V+ G ++ +EC A G P P+I W+ + V + V G L E
Sbjct: 27 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG 86
Query: 2008 RTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHI 2067
++L D G+Y C A N AG L V P V+ + + G + +
Sbjct: 87 QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVEL 146
Query: 2068 HCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNG-TLYIRNLAPKDSGRYECVAAN 2126
C P P V W D + P +L V +G L I D GRY+CVA +
Sbjct: 147 QCWTSGVPTPQVEWT-KDRQPVLPG---GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFS 202
Query: 2127 LVGSARRTVQLNVQRAAANARITGTSPR-RTDVRYGGTLKLDCSASGDPWPRILWRLPSK 2185
G R QL V A I G++ V ++L C A G P P I W
Sbjct: 203 PAGQQARDFQLRVH---APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG- 258
Query: 2186 RMIDALFSFDSRIKVFANG--TLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPA 2243
AL +++ V+ G L + DAG Y C A N VG ++DV + P
Sbjct: 259 ----ALLPTSTKV-VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 313
Query: 2244 KIEHKEENDH--KVFYGGDLKVDCVATGLPNPEISW---SLPDGSLVNSFMQSDDSGGRT 2298
IE + K G + ++CVA G P+P +SW LP S +++D S
Sbjct: 314 -IEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS---- 368
Query: 2299 KRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQV 2358
L G G Y+C A + G+ ++ V+V P + + V
Sbjct: 369 ---------VLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTT 419
Query: 2359 PYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYT 2417
G + + C+A G P+P + WL N Q+ GT L I + SG +
Sbjct: 420 IVGQPLELPCQASGSPVPTIQWLQ--NGRPAEELAGVQVASQGTTLHIDHVELDHSGLFA 477
Query: 2418 CLVRNSAGEDRKTVWIHVNVQ-PPKI-------------NGNPNPITTVREIAAGGSRKL 2463
C N AG V + V+ + P + + + P + G
Sbjct: 478 CQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHP 537
Query: 2464 IDCKAEGIPTPRVLWAFPEGV----VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCM 2519
EG +P LW P G+ LP P L I + D C
Sbjct: 538 KPPLVEGWCSPGSLWGEPTGIPVAYSLPPP-------------LQIEKVDLRDEGIYTCA 584
Query: 2520 ARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLP 2579
A N GE++ + L VL P I P+++ + A +++L C A+G P P + W
Sbjct: 585 ATNLAGESKREVALKVLVPPN--IEPGPVNKAVLENA--SVTLECLASGVPPPDVSWFKG 640
Query: 2580 NGTDLQSGQQLQRFYHKADG-MLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPE 2638
+ Q DG +L I DAG+YRCVA N AG TE L+V + P
Sbjct: 641 H----QPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPR 696
Query: 2639 ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTV 2698
++ ++L C GA W L +G + T G LT+
Sbjct: 697 ITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMW-LKDGNPVSPAGTPGLQVFPGGRVLTL 755
Query: 2699 REASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAM 2758
A D G Y C + G + V+ + PP I E V +V L C +
Sbjct: 756 ASARASDSGRYSCVAVSAVGEDRQDV-VLQVHMPPSILGEELNVSVV-ANESVALECQSH 813
Query: 2759 GIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
+P ++W D L+ L ++ L L + A DAG Y C A N G
Sbjct: 814 AMPPPVLSW-WKDGRPLEPRPGVHLSADKAL-----LQVDRADVWDAGHYTCEALNQAGH 867
Query: 2819 DSKTTYIHVF 2828
K ++V+
Sbjct: 868 SEKHYNLNVW 877
Score = 171 bits (433), Expect = 9e-42
Identities = 204/834 (24%), Positives = 323/834 (38%), Gaps = 110/834 (13%)
Query: 2043 AALPPVIHQE-KLENISLPPGLSIHIHCTAKAAPLPSVRWV------------LGDGTQI 2089
+ +PP I ++ + N+S G S+ + C A P+P + W+ G G +
Sbjct: 13 SVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDL 72
Query: 2090 RPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQL------NVQRAA 2143
Q + G+ + +L+ + DSG Y C A N G+A+R L +V A
Sbjct: 73 GWGQ-VGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAG 131
Query: 2144 ANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFAN 2203
A + G + G ++L C SG P P++ W + ++ ++V +
Sbjct: 132 AAQEVLGLA--------GADVELQCWTSGVPTPQVEWTKDRQPVLPG----GPHLQVQED 179
Query: 2204 G-TLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLK 2262
G L + D G Y CVA + G ++ V P E + V ++
Sbjct: 180 GQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQ 239
Query: 2263 VDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG--TLYFNEVGMREEG 2320
+ C A G+P P I+W DG+L+ T VV+ G L + G
Sbjct: 240 LLCEARGVPTPNITW-FKDGALL-----------PTSTKVVYTRGGRQLQLGRAQSSDAG 287
Query: 2321 DYTCFAENQVGKDEMRVRVKVVTAPAT--IRNKTYLAVQVPYGDVVTVACEAKGEPMPKV 2378
YTC A N VG E R+ V P + Y+ V+ G V + C A+G P P +
Sbjct: 288 VYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYV-VKAVAGRPVALECVARGHPSPTL 346
Query: 2379 TWLSPTNKVIPTS-SEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVN 2436
+W ++ +P + S + ++ DG++L ++ + SG Y+C+ + AGE + V
Sbjct: 347 SW---HHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ 403
Query: 2437 VQPPKINGNP-NPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRI 2495
V P + +TT+ G + C+A G P P + W G PA
Sbjct: 404 VPPQLLVAEGLGQVTTI-----VGQPLELPCQASGSPVPTIQW-LQNG--RPAEELAGVQ 455
Query: 2496 TVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAM 2555
+L I + S C A NE G A ++++V + PI +
Sbjct: 456 VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGX 515
Query: 2556 AGH-TISLNCS---------------AAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADG 2599
H + C G +P +W P G + +
Sbjct: 516 EHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVA---------YSLPP 566
Query: 2600 MLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPC 2659
L I + D G Y C A N AG ++R V+LKV + P N +++ ++ L C
Sbjct: 567 PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVN-KAVLENASVTLEC 625
Query: 2660 TPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGP 2719
G SW H +G +D L + +A + D G+Y C G
Sbjct: 626 LASGVPPPDVSWFKG---HQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGS 682
Query: 2720 SVTSIPVIVIAYPPRIT---SEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLK 2776
+ + + PPRIT S P PV+ P V+L C A G P + W LK
Sbjct: 683 TELRYG-LRVNVPPRITLPPSLPGPVLVNTP---VRLTCNATGAPSPTLMW-------LK 731
Query: 2777 AGVQARLYGNRFLH--PQGS-LTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
G G L P G LT+ A D+G Y C+A + +G D + + V
Sbjct: 732 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV 785
Score = 147 bits (372), Expect = 1e-34
Identities = 155/616 (25%), Positives = 241/616 (39%), Gaps = 44/616 (7%)
Query: 2233 VLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVN-----S 2287
+L V+ P+ E + + G L ++C A G P PEI W L D LV +
Sbjct: 8 LLNTGSVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVW-LKDAQLVGVPLGWA 66
Query: 2288 FMQSDDSGGRTKRYVVFNNG-TLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPA 2346
D G+ + + + G +L+F + + G Y+C AENQ G + + V+T P+
Sbjct: 67 GYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPS 126
Query: 2347 TIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-I 2405
+ V G V + C G P P+V W V+P Q+ +DG +L I
Sbjct: 127 VLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLP-GGPHLQVQEDGQVLRI 185
Query: 2406 QKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLID 2465
+ D G Y C+ + AG+ + + V+ P N V E +
Sbjct: 186 TGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVME----DHLVQLL 241
Query: 2466 CKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG 2525
C+A G+PTP + W F +G +LP + G L + + SD+ C A N G
Sbjct: 242 CEARGVPTPNITW-FKDGALLPTS--TKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 298
Query: 2526 EARLILQLTVLEPMEKPIFHDPISEK--ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTD 2583
A +L V P P + A+AG ++L C A G P+P+L W +
Sbjct: 299 AAEKATRLDVYVP---PTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW---HHEG 352
Query: 2584 LQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPE-ANKQ 2642
L + + +L + +G Y CVA + AG S++V + P+ +
Sbjct: 353 LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAE 412
Query: 2643 YHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNG-TLTVREA 2701
V+ I G+ L+LPC G+ W L NG E L V + G TL +
Sbjct: 413 GLGQVTTIVGQPLELPCQASGSPVPTIQW-LQNGRPAE---ELAGVQVASQGTTLHIDHV 468
Query: 2702 SVFDRGTYVCRMETEYGPSVTSIPVIVIA-YPPRITSEPTPVIYTRPGNTVKLNCMAMGI 2760
+ G + C+ E G + + V V + P + P+ G + A
Sbjct: 469 ELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLE--VPIGQYHWGXEHHSSFPAACD 526
Query: 2761 PKADITWELPDKSHLKAGVQARLYGNRFLHPQG---------SLTIQHATQRDAGFYKCM 2811
P W K L G + G+ + P G L I+ RD G Y C
Sbjct: 527 PPVHRGWGAHPKPPLVEGWCSP--GSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCA 584
Query: 2812 AKNILGSDSKTTYIHV 2827
A N+ G + + V
Sbjct: 585 ATNLAGESKREVALKV 600
Score = 87.8 bits (216), Expect = 1e-16
Identities = 82/307 (26%), Positives = 117/307 (38%), Gaps = 37/307 (12%)
Query: 2543 IFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWV------------LPNGTDLQSGQQL 2590
I D ++ MAG +++L C A G P P +VW+ G DL GQ
Sbjct: 19 IREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVG 78
Query: 2591 QRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEA-NKQYHNLVSI 2649
LH + D+G Y C A N AG +R L V P V
Sbjct: 79 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLG 138
Query: 2650 INGETLKLPCTPPGAGQGRFSWT------LPNGMHLEGPQTLGRVSLLDNGTLTVREASV 2703
+ G ++L C G + WT LP G HL+ + D L + + V
Sbjct: 139 LAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQE--------DGQVLRITGSHV 190
Query: 2704 FDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKA 2763
D G Y C + G + V A P S T + + V+L C A G+P
Sbjct: 191 GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP 250
Query: 2764 DITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQ--HATQRDAGFYKCMAKNILGSDSK 2821
+ITW D + L + ++ +G +Q A DAG Y C A N +G+ K
Sbjct: 251 NITW-FKDGALLPT-------STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEK 302
Query: 2822 TTYIHVF 2828
T + V+
Sbjct: 303 ATRLDVY 309
Score = 80.9 bits (198), Expect = 2e-14
Identities = 66/198 (33%), Positives = 92/198 (46%), Gaps = 12/198 (6%)
Query: 477 VMIEP---SGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFS 533
V++ P S V R+ VLEG +L C P + W L DGS L M P +F
Sbjct: 1930 VLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW-LKDGSPLGQDMG-PHLRF- 1986
Query: 534 ILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKD-TVTIGKNPG 592
L G L +K + SD+G Y C+A D ++ V V P T D + T+ PG
Sbjct: 1987 YLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2046
Query: 593 ESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCV 652
E VT+ C P H+SW+ + H TL I KVQ++D+G + CV
Sbjct: 2047 ELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHG---SGHTLRISKVQLADAGIFTCV 2103
Query: 653 AVNQQG-AD-HFTVGITV 668
A + G AD +FT+ + V
Sbjct: 2104 AASPAGVADRNFTLQVQV 2121
Score = 69.3 bits (168), Expect = 5e-11
Identities = 49/166 (29%), Positives = 76/166 (45%), Gaps = 12/166 (7%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLY 553
GG QL C V+ P I W+ DG L+ L +G L I+ E D+G Y
Sbjct: 2951 GGSIQLDCVVRGDPVPDIHWI-KDGLPLRG-----SHLRHQLQNGSLTIRRTERDDAGRY 3004
Query: 554 QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWIL 613
QC+A+ + + V +++QS E +T+ G+ V L C A P + W+
Sbjct: 3005 QCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTV--RSGDDVALRCQATGEPTPTIEWLQ 3062
Query: 614 PNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
+ L + + LP+G+L + V+ D+G Y CVA N G+
Sbjct: 3063 AGQ----PLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGS 3104
Score = 66.6 bits (161), Expect = 3e-10
Identities = 49/169 (28%), Positives = 83/169 (49%), Gaps = 10/169 (5%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSG 551
L G L C+V+A +P I W DG +L+ +D ++F +L+++++ +DSG
Sbjct: 2312 LAPGQLVLECSVEAEPAPKITWHR-DGIVLQ---EDAHTQFPERGR-FLQLQALSTADSG 2366
Query: 552 LYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSW 611
Y C A+ + +RV + + T + V + N ++ LPC A +P +SW
Sbjct: 2367 DYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSW 2424
Query: 612 ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD 660
R+ D + +LP G+L I V D+G+Y C+A N G+D
Sbjct: 2425 --RKDRVPLD-PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 2470
Score = 65.9 bits (159), Expect = 6e-10
Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 14/182 (7%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSD 549
VL P +L+CN + SP++ W L DG+ + +P P + G L + S SD
Sbjct: 707 VLVNTPVRLTCNATGAPSPTLMW-LKDGNPV-SPAGTPG--LQVFPGGRVLTLASARASD 762
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHL 609
SG Y C+A DR + V P + E+ V++ N ESV L C + A+P L
Sbjct: 763 SGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVAN--ESVALECQSHAMPPPVL 820
Query: 610 SWILPNRRIINDLANTSHVYM-LPNGTLSIPKVQVSDSGYYRCVAVNQQG--ADHFTVGI 666
SW R L V++ L + + V D+G+Y C A+NQ G H+ + +
Sbjct: 821 SWWKDGR----PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 876
Query: 667 TV 668
V
Sbjct: 877 WV 878
Score = 63.2 bits (152), Expect = 4e-09
Identities = 57/222 (25%), Positives = 99/222 (44%), Gaps = 15/222 (6%)
Query: 477 VMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILS 536
V++ + + + TV L C + P+I W L +G P + +L
Sbjct: 1561 VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW-LQNGLPFS-----PSPRLQVLE 1614
Query: 537 SGW-LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESV 595
G L++ + E +D+ Y C+A+ + ++ + VQ P + A D + SV
Sbjct: 1615 DGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPP-RIAGLDLEQVTAILNSSV 1673
Query: 596 TLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAV 654
+LPC+ A P ++W ++ L+ V++LP TL + + ++SDSG Y C A+
Sbjct: 1674 SLPCDVHAHPNPEVTWYKDSQA----LSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEAL 1729
Query: 655 NQQGADHFTVGITVTKKGSGLPSKRGRRPGAKALSRVREDIV 696
N G D V ++V + + RG P L RV + V
Sbjct: 1730 NAAGRDQKLVQLSVLVPPAFRQAPRG--PQDAVLVRVGDKAV 1769
Score = 61.6 bits (148), Expect = 1e-08
Identities = 55/219 (25%), Positives = 96/219 (43%), Gaps = 21/219 (9%)
Query: 477 VMIEPSGAVQRDQTVLE--GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSI 534
V + P+ + +TV + G P L+C+V +P++ W+ + P++ +
Sbjct: 1838 VQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKD-----RMPVESSAVHGVV 1892
Query: 535 LSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLV----QSPSTQPAEKDTVTIGKN 590
G L++ ++P+ +G Y C+A+ R + V V + S+ A + V
Sbjct: 1893 SRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVL---- 1948
Query: 591 PGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYR 650
G+ V L C A P ++W+ + D+ Y L G+L + ++ SD+G Y
Sbjct: 1949 EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY-LDGGSLVLKGLRASDAGAYT 2007
Query: 651 CVAVNQQGADH--FTVGITV---TKKGSGLPSKRGRRPG 684
CVA N G D TV + V K+G+ RPG
Sbjct: 2008 CVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2046
Score = 61.2 bits (147), Expect = 1e-08
Identities = 51/202 (25%), Positives = 86/202 (42%), Gaps = 21/202 (10%)
Query: 463 ISTKDTRQARGRSWVMIEPSGAVQR---DQTVLEGGPCQLSCNVKASESPSIFWVLPDGS 519
I+ A G++ ++++ ++ D + EG L C + S P+I W DG
Sbjct: 2736 IAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWD-KDGQ 2794
Query: 520 ILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ-VRDEMDRMVYRVLVQSP--S 576
P+ + KF+I SG L +K++E D+G Y C A+ R V+ ++ P +
Sbjct: 2795 ----PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFT 2850
Query: 577 TQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTL 636
T P ++ G+ + L C A P + W + +R + ++ TL
Sbjct: 2851 TLPGDRSL-----RLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQD-----GGSTL 2900
Query: 637 SIPKVQVSDSGYYRCVAVNQQG 658
V DSG Y C A N+ G
Sbjct: 2901 QRAAVSREDSGTYVCWAENRVG 2922
Score = 60.5 bits (145), Expect = 2e-08
Identities = 46/175 (26%), Positives = 72/175 (41%), Gaps = 14/175 (8%)
Query: 496 PCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSDSGLYQ 554
P L C P+I W + + P +L+ GW L++ + DSGLY
Sbjct: 1087 PLTLLCEAMGIPPPAIRWFRGEEPV------SPGEDTYLLAGGWMLKMTQTQEQDSGLYS 1140
Query: 555 CIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILP 614
C+A R + V V P + E I G++ L CN P+ L+W
Sbjct: 1141 CLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 1200
Query: 615 NRRIINDLANTSHVYMLPNGT-LSIPKVQVSDSGYYRCVAVNQQG--ADHFTVGI 666
R LA ++ P+G L + + +S +G+Y C+A N G HF + +
Sbjct: 1201 GR----PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 1251
Score = 60.1 bits (144), Expect = 3e-08
Identities = 52/185 (28%), Positives = 80/185 (43%), Gaps = 19/185 (10%)
Query: 484 AVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIK 543
+ + TV P L C A SP+I W + DG AP + + + + L+I
Sbjct: 1264 SADEEVTVTVNNPISLICEALAFPSPNITW-MKDG----APFEASRNIQLLPGTHGLQIL 1318
Query: 544 SMEPSDSGLYQCIAQVRDEMDRMV--YRVLVQSPSTQPAEKDTVTIGKNP-----GESVT 596
+ + D+G Y C+ V +E+ V Y V V P + + +G ++T
Sbjct: 1319 NAQKEDAGQYTCV--VTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLT 1376
Query: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTL-SIPKVQVSDSGYYRCVAVN 655
L C + A+P + W + + +S + +L G L I QVSDSG Y CVA N
Sbjct: 1377 LECESWAVPPPTIRWYKDGQPV----TPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1432
Query: 656 QQGAD 660
G D
Sbjct: 1433 VAGED 1437
Score = 58.5 bits (140), Expect = 9e-08
Identities = 46/175 (26%), Positives = 72/175 (41%), Gaps = 13/175 (7%)
Query: 486 QRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSM 545
Q D TV P L+C+ +P++ W S A + S + + SG L I
Sbjct: 2581 QTDFTVTMMAPVVLTCHSTGIPAPTVSW-----SKAGAQLGARGSGYRVSPSGALEIGQA 2635
Query: 546 EPSDSGLYQCIAQVRDEM-DRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
P +G Y C A+ + + V+ + SP +P + + E V LPC A I
Sbjct: 2636 LPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAE---EEVLLPCEASGI 2692
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
P ++W + ++ +LP G L I D+G Y C+A N G+
Sbjct: 2693 PRPTITWQKEGLNVATGVSTQ----VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2743
Score = 57.8 bits (138), Expect = 2e-07
Identities = 62/233 (26%), Positives = 97/233 (41%), Gaps = 16/233 (6%)
Query: 439 IQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTV--LEGGP 496
+QL R QS+ V Y + S + + + R +V GA R V + G P
Sbjct: 276 LQLGRAQSSDAGV---YTCKASNAVGAAE-KATRLDVYVPPTIEGAGGRPYVVKAVAGRP 331
Query: 497 CQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCI 556
L C + SP++ W + ++ ++ S+L R++S + SGLY C+
Sbjct: 332 VALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVL-----RLESPGEASSGLYSCV 386
Query: 557 AQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNR 616
A + Y V VQ P + + G+ + LPC A P + W L N
Sbjct: 387 ASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW-LQNG 445
Query: 617 RIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
R +LA V + G TL I V++ SG + C A N+ G V ++V
Sbjct: 446 RPAEELAG---VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 495
Score = 57.0 bits (136), Expect = 3e-07
Identities = 47/189 (24%), Positives = 78/189 (41%), Gaps = 16/189 (8%)
Query: 481 PSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWL 540
P+ V +QT L L C +P + W + P+D +F IL G L
Sbjct: 2398 PAVNVSVNQTAL------LPCQADGVPAPLVSWRKD-----RVPLDPRSPRFEILPEGSL 2446
Query: 541 RIKSMEPSDSGLYQCIAQVRDEMDRMVYRV-LVQSPSTQPAEKDTVTIGKNPGESVTLPC 599
RI+ + D+G Y C+A DR + +++ P+ P+ + P LPC
Sbjct: 2447 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP---ALLPC 2503
Query: 600 NALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
A P+ + W +++ L ++ +LP+ L + DS + CV N+ G
Sbjct: 2504 EASGSPKPLVVWWKDGQKLDFRLQQGAY-RLLPSNALLLTAPGPQDSAQFECVVSNEVGE 2562
Query: 660 DHFTVGITV 668
H +TV
Sbjct: 2563 AHRLYQVTV 2571
Score = 56.6 bits (135), Expect = 3e-07
Identities = 44/162 (27%), Positives = 70/162 (43%), Gaps = 18/162 (11%)
Query: 508 SPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIA-QVRDEMDRM 566
SP W P G + + P L+I+ ++ D G+Y C A + E R
Sbjct: 547 SPGSLWGEPTGIPVAYSLPPP-----------LQIEKVDLRDEGIYTCAATNLAGESKRE 595
Query: 567 VYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTS 626
V ++ P+ +P + + SVTL C A +P +SW ++ + + + T
Sbjct: 596 VALKVLVPPNIEPGPVNKAVL---ENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTV 652
Query: 627 HVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
V L I + Q+SD+G YRCVA N G+ G+ V
Sbjct: 653 SV---DGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV 691
Score = 55.8 bits (133), Expect = 6e-07
Identities = 50/199 (25%), Positives = 78/199 (39%), Gaps = 10/199 (5%)
Query: 472 RGRSWVMIEPSGAVQRDQ--TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPD 529
+GR ++EP T+ P L C S P + W DG L +
Sbjct: 2472 QGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVW-WKDGQKLDFRLQQ-- 2528
Query: 530 SKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGK 589
+ +L S L + + P DS ++C+ +Y+V V P T ++ T+
Sbjct: 2529 GAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTM 2588
Query: 590 NPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYY 649
V L C++ IP +SW ++ A S + P+G L I + +G Y
Sbjct: 2589 MA--PVVLTCHSTGIPAPTVSWSKAGAQLG---ARGSGYRVSPSGALEIGQALPIHAGRY 2643
Query: 650 RCVAVNQQGADHFTVGITV 668
C A N G H V +TV
Sbjct: 2644 TCSARNSAGVAHKHVFLTV 2662
Score = 55.5 bits (132), Expect = 8e-07
Identities = 45/174 (25%), Positives = 65/174 (37%), Gaps = 19/174 (10%)
Query: 492 LEGGPCQLSCNVKASESPSIFW------VLPDGSILKAPMDDPDSKFSILSSGWLRIKSM 545
L G +L C +P + W VLP G L+ D LRI
Sbjct: 139 LAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV----------LRITGS 188
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP 605
D G YQC+A +++ V +P T +T + V L C A +P
Sbjct: 189 HVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP 248
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
+++W + +T VY L + + Q SD+G Y C A N GA
Sbjct: 249 TPNITWFKDGALLPT---STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA 299
Score = 55.1 bits (131), Expect = 1e-06
Identities = 37/174 (21%), Positives = 70/174 (40%), Gaps = 19/174 (10%)
Query: 486 QRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSM 545
Q D V+ G +L C + P + W+ +L ++ S L+++++
Sbjct: 2131 QNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPS---------LQLEAV 2181
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP 605
DSG Y C+A R +++ V P + PG + L C+A P
Sbjct: 2182 GAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTP 2241
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
+ +++W + + L N + + ++V D+G Y C+A + GA
Sbjct: 2242 QPNITWHKDGQALTR----------LENNSRATRVLRVRDAGLYTCLAESPAGA 2285
Score = 54.7 bits (130), Expect = 1e-06
Identities = 49/184 (26%), Positives = 71/184 (38%), Gaps = 13/184 (7%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
++ VLE L C P + W P+ + LRI+ +
Sbjct: 612 NKAVLENASVTLECLASGVPPPDVSWFKGH-----QPVSSWMGVTVSVDGRVLRIEQAQL 666
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLVQSPS--TQPAEKDTVTIGKNPGESVTLPCNALAIP 605
SD+G Y+C+A + Y + V P T P + P V L CNA P
Sbjct: 667 SDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP---VRLTCNATGAP 723
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
L W+ + A T + + P G L++ + SDSG Y CVAV+ G D V
Sbjct: 724 SPTLMWLKDGNPV--SPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV 781
Query: 665 GITV 668
+ V
Sbjct: 782 VLQV 785
Score = 54.7 bits (130), Expect = 1e-06
Identities = 50/190 (26%), Positives = 73/190 (38%), Gaps = 26/190 (13%)
Query: 534 ILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGE 593
+L G LRI P D+G Y CIA+ R++VQ P E + G
Sbjct: 2714 VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV--IENGLPDLSTTEGS 2771
Query: 594 SVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
LPC A PE +++W + + + + P+G L + ++ D+G Y C A
Sbjct: 2772 HAFLPCKARGSPEPNITWDKDGQPVSGAEGKFT---IQPSGELLVKNLEGQDAGTYTCTA 2828
Query: 654 VNQQGADHFTVGIT--VTKKGSGLPSKRGRRPGAKALSR-------------------VR 692
N G V +T V + LP R R G + R V
Sbjct: 2829 ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT 2888
Query: 693 EDIVEDEGGS 702
E + E +GGS
Sbjct: 2889 EGVSEQDGGS 2898
Score = 51.2 bits (121), Expect = 1e-05
Identities = 47/176 (26%), Positives = 73/176 (41%), Gaps = 21/176 (11%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
VL+G L CNV P + W DG P+ D+ L++ S +
Sbjct: 1175 VLDGQTAHLMCNVTGHPQPKLTW-FKDG----RPLARGDAHHISPDGVLLQVLQANLSSA 1229
Query: 551 GLYQCIA--QVRDEMDRMVYRVL----VQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
G Y CIA V ++ VL + + A+++ NP ++L C ALA
Sbjct: 1230 GHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP---ISLICEALAF 1286
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGT--LSIPKVQVSDSGYYRCVAVNQQG 658
P +++W+ + ++ +LP GT L I Q D+G Y CV N+ G
Sbjct: 1287 PSPNITWMKDGA----PFEASRNIQLLP-GTHGLQILNAQKEDAGQYTCVVTNELG 1337
Score = 50.8 bits (120), Expect = 2e-05
Identities = 45/175 (25%), Positives = 75/175 (42%), Gaps = 20/175 (11%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
D+++ G L C + S +P I W + D + + + L+ ++
Sbjct: 2855 DRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQD-------GGSTLQRAAVSR 2907
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
DSG Y C A+ R + V V V+ E + + + G S+ L C P
Sbjct: 2908 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLV-EPVGGSIQLDCVVRGDPVP 2966
Query: 608 HLSWI---LPNRRIINDLANTSHV-YMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ WI LP R SH+ + L NG+L+I + + D+G Y+C+A N+ G
Sbjct: 2967 DIHWIKDGLPLRG--------SHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMG 3013
Score = 50.4 bits (119), Expect = 2e-05
Identities = 61/217 (28%), Positives = 87/217 (40%), Gaps = 48/217 (22%)
Query: 477 VMIEPSGAVQRDQTVLEGGPCQ----------LSCNVKASESPSIFWVLPDGSILKAPMD 526
V+I PS + +D + E G + L C A P+I W DG +
Sbjct: 1347 VLIPPS--ISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY-KDGQPVT---- 1399
Query: 527 DPDSKFSILSSG-WLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSP---------- 575
P S+ +L G L+I+ + SDSG Y C+A D + VL+Q P
Sbjct: 1400 -PSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFS 1458
Query: 576 ------STQPAEKDTVT-----IGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLAN 624
S + + VT + NP L C+ AIP L+W R L+
Sbjct: 1459 AAFEILSREEEARGGVTEYREIVENNP---AYLYCDTNAIPPPDLTWY----REDQPLSA 1511
Query: 625 TSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGAD 660
V +L G L IP V+ ++G Y C A N+ G D
Sbjct: 1512 GDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGED 1548
Score = 49.7 bits (117), Expect = 4e-05
Identities = 56/204 (27%), Positives = 84/204 (41%), Gaps = 23/204 (11%)
Query: 479 IEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG 538
IE SG + ++ G P +L C+ + + P+I W DG L L +
Sbjct: 2214 IEDSGQ-PTELSLTPGAPMELLCDAQGTPQPNITWH-KDGQALTR-----------LENN 2260
Query: 539 WLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEK-DTVTIGKNPGESVTL 597
+ + D+GLY C+A+ +RV VQ+P + +G PG+ V L
Sbjct: 2261 SRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-L 2319
Query: 598 PCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGT-LSIPKVQVSDSGYYRCVAVNQ 656
C+ A P ++W R L +H G L + + +DSG Y C A N
Sbjct: 2320 ECSVEAEPAPKITW----HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 2375
Query: 657 QGADH--FTVGI-TVTKKGSGLPS 677
G+ F V I TV SG P+
Sbjct: 2376 AGSTSVAFRVEIHTVPTIRSGPPA 2399
Score = 48.5 bits (114), Expect = 9e-05
Identities = 44/183 (24%), Positives = 73/183 (39%), Gaps = 14/183 (7%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
T + L C+V A +P + W ++ + F + + L++ SD
Sbjct: 1666 TAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG-----EEVFLLPGTHTLQLGRARLSD 1720
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQSP----STQPAEKDTVTIGKNPGESVTLPCNALAIP 605
SG+Y C A D+ + ++ V P +D V + G+ L C A+P
Sbjct: 1721 SGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLV--RVGDKAVLSCETDALP 1778
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVG 665
E ++W + ++ LA + + L I + QVSD G Y C N G T
Sbjct: 1779 EPTVTWYKDGQPLV--LAQRTQA-LRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT 1835
Query: 666 ITV 668
+TV
Sbjct: 1836 LTV 1838
Score = 43.9 bits (102), Expect = 0.002
Identities = 41/182 (22%), Positives = 67/182 (36%), Gaps = 22/182 (12%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW------------ 539
+ G L C+ P I W L D ++ P+ + + GW
Sbjct: 31 MAGQSLTLECDANGFPVPEIVW-LKDAQLVGVPLGWAGYGWDL---GWGQVGGHRLLDEG 86
Query: 540 --LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTL 597
L ++ DSGLY C A+ + + + +LV +P + + G V L
Sbjct: 87 QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVEL 146
Query: 598 PCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQ 656
C +P + W + + L H+ + +G L I V D G Y+CVA +
Sbjct: 147 QCWTSGVPTPQVEWTKDRQPV---LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP 203
Query: 657 QG 658
G
Sbjct: 204 AG 205
Score = 39.3 bits (90), Expect = 0.056
Identities = 45/173 (26%), Positives = 66/173 (38%), Gaps = 13/173 (7%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
TV EG P +LSC + P I W DG L P + + L + + +
Sbjct: 891 TVREGHPTRLSCECRGVPFPKISW-RKDGQPL--PGEGAGLQHVSAVGRLLYLGQAQLAQ 947
Query: 550 SGLY--QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
G Y +C V + + V V P E T G + TL CNA P
Sbjct: 948 EGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA-TLECNATGKPPP 1006
Query: 608 HLSWILPNRRIINDLANTSHVYMLPN--GTLSIPKVQVSDSGYYRCVAVNQQG 658
++W + + +L L N +L + + Q + +G Y CVA N G
Sbjct: 1007 TVTWERDGQPVGAELG-----LQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 1054
Score = 36.6 bits (83), Expect = 0.36
Identities = 22/71 (30%), Positives = 33/71 (46%), Gaps = 6/71 (8%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
+D TV G L C +P+I W L G L+A + L G L ++++E
Sbjct: 3034 QDMTVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRA-----SRRLRTLPDGSLWLENVE 3087
Query: 547 PSDSGLYQCIA 557
D+G Y C+A
Sbjct: 3088 TGDAGTYDCVA 3098
Score = 33.1 bits (74), Expect = 4.0
Identities = 34/160 (21%), Positives = 57/160 (35%), Gaps = 7/160 (4%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ 558
L C A P + W DG P++ L++ + D+G Y C A
Sbjct: 808 LECQSHAMPPPVLSW-WKDGR----PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 862
Query: 559 VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRI 618
+ Y + V P +++ T+ G L C +P +SW + +
Sbjct: 863 NQAGHSEKHYNLNVWVAPVFPL-RESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPL 921
Query: 619 INDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ A HV + L + + Q++ G Y C N G
Sbjct: 922 PGEGAGLQHVSAV-GRLLYLGQAQLAQEGTYTCECSNVVG 960
Score = 32.7 bits (73), Expect = 5.2
Identities = 41/184 (22%), Positives = 68/184 (36%), Gaps = 19/184 (10%)
Query: 859 SSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITSTEGDLKGTAAPTLI---- 914
+S +G + H ++++ P V EE+V++++ S + G PT+
Sbjct: 1541 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1600
Query: 915 SEPYEPSPTLHTLD--TVYEKPTHEETATEGWSAADVGSSPEPTSSEYEPPLDAVSLAES 972
P+ PSP L L+ V + T E AD S ++ +L
Sbjct: 1601 GLPFSPSPRLQVLEDGQVLQVSTAE--------VADAASYMCVAENQAGSAEKLFTLRVQ 1652
Query: 973 EPMQYFDPDLETKSQPDEDKMKEDTFAHLTPTPTI-WVNDSSTSQLFEDSTIGEPGVPGQ 1031
P + DLE + + H P P + W DS L E+ + +PG
Sbjct: 1653 VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFL----LPGT 1708
Query: 1032 SHLQ 1035
LQ
Sbjct: 1709 HTLQ 1712
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 307 bits (786), Expect = 1e-82
Identities = 269/973 (27%), Positives = 408/973 (41%), Gaps = 84/973 (8%)
Query: 1860 PQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQ 1919
P +S+T C+A G P+P +TW K Q L+N + R ++
Sbjct: 2311 PTELSLTPGAPMELLCDAQGTPQPNITWHKDG-----------QALTRLENNSRATRVLR 2359
Query: 1920 VQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGD-TIAMECLAKGTP 1978
V+D G Y C A + G + V P I+ V L + +EC + P
Sbjct: 2360 VRDAGLYTCLAESPAGAIEKSFRVRVQAP-PNIVGPRGPRFVVGLAPGQLVLECSVEAEP 2418
Query: 1979 APQISWIFPDRRVWQ----TVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGAD 2034
AP+I+W D V Q T P GR L ++ S +D G Y C A NAAG+
Sbjct: 2419 APKITW-HRDGIVLQEDAHTQFPERGRF-------LQLQALSTADSGDYSCTARNAAGST 2470
Query: 2035 SLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQF 2094
S+A R+ + +P + N+S+ + + C A P P V W D + P
Sbjct: 2471 SVAFRVEIHTVPTIRSGPPAVNVSV--NQTALLPCQADGVPAPLVSW-RKDRVPLDPRS- 2526
Query: 2095 LHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPR 2154
+ P G+L I+ + +D+G Y C+A+N GS R+ L V A A SP
Sbjct: 2527 --PRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIA----PSPS 2580
Query: 2155 RTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDK 2214
+ L C ASG P P ++W +++ L ++ + L++ + +
Sbjct: 2581 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ--GAYRLLPSNALLLTAPGPQ 2638
Query: 2215 DAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPE 2274
D+ + CV N+VG+ + + +V V + P + ++ D V + + C +TG+P P
Sbjct: 2639 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD--DQTDFTVTMMAPVVLTCHSTGIPAPT 2696
Query: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
+SWS L G R Y V +G L + G YTC A N G
Sbjct: 2697 VSWSKAGAQL----------GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2746
Query: 2335 MRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEK 2394
V + V +P V+ + V + CEA G P P +TW V S
Sbjct: 2747 KHVFLTVQASPVV--KPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST- 2803
Query: 2395 YQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVRE 2454
Q+ G L I A D+GNY C+ +NSAG + V V P NG P+ TT
Sbjct: 2804 -QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTE-- 2860
Query: 2455 IAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSV 2514
GS + CKA G P P + W V A + T+ +G L +++L D+
Sbjct: 2861 ----GSHAFLPCKARGSPEPNITWDKDGQPVSGAE---GKFTIQPSGELLVKNLEGQDAG 2913
Query: 2515 QLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSL 2574
C A N G AR + LT+L P+F ++ + G + L C+A G+PTP +
Sbjct: 2914 TYTCTAENAVGRARRRVHLTILV---LPVFTTLPGDRSLRL-GDRLWLRCAARGSPTPRI 2969
Query: 2575 VWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVG 2634
W + N + G Q L + +S D+G Y C A N G T+ + + V
Sbjct: 2970 GWTV-NDRPVTEGVSEQ----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 3024
Query: 2635 LKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNG 2694
P + + + G +++L C G W + +G+ L G + L NG
Sbjct: 3025 EAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHW-IKDGLPLRGSHLRHQ---LQNG 3080
Query: 2695 TLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLN 2754
+LT+ D G Y C E E G + + ++V+ P EP + R G+ V L
Sbjct: 3081 SLTIHRTERDDAGRYQCLAENEMGVA-KKVVILVLQSAPVFQVEPQDMT-VRSGDDVALR 3138
Query: 2755 CMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKN 2814
C A G P I W L+AG R P GSL +++ DAG Y C+A N
Sbjct: 3139 CQATGEPTPTIEW-------LQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHN 3191
Query: 2815 ILGSDSKTTYIHV 2827
+LGS + ++ V
Sbjct: 3192 LLGSATARAFLVV 3204
Score = 295 bits (756), Expect = 3e-79
Identities = 287/986 (29%), Positives = 422/986 (42%), Gaps = 113/986 (11%)
Query: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG-TLVIRKVQ 1919
+ V+V A + C A G P P ++W + G +P+ R+Q VL++G L + +
Sbjct: 1662 EEVTVNASSTVSLQCPALGNPVPTISW--LQNGLPFSPSPRLQ---VLEDGQVLQVSTAE 1716
Query: 1920 VQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPA 1979
V D YMC A N G + L V V P+I + VT L ++++ C P
Sbjct: 1717 VADAASYMCVAENQAGSAEKLFTLRVQVP-PRIAGLDLEQVTAILNSSVSLPCDVHAHPN 1775
Query: 1980 PQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIR 2039
P+++W + D Q +S E L TL + A SD G+Y C A NAAG D ++
Sbjct: 1776 PEVTW-YKDS---QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 1831
Query: 2040 LHVAALPPVIHQEKL---ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI---RPSQ 2093
L V +PP Q + + + G + C A P P+V W DG + + +Q
Sbjct: 1832 LSVL-VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK-DGQPLVLAQRTQ 1889
Query: 2094 FLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSP 2153
L G L I+ D G Y C +N+ G A RT L VQ T +P
Sbjct: 1890 ALRGGQ------RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPP-----TFENP 1938
Query: 2154 RRTDVRY--GGTLKLDCSASGDPWPRILW---RLPSKRMIDALFSFDSRIKVFANGTLVV 2208
+ V G L L C SG P P + W R+P + A+ SR G L +
Sbjct: 1939 KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES--SAVHGVVSR-----GGRLQL 1991
Query: 2209 KSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVAT 2268
+ AG Y CVA N + V V++ P +H V G ++++DC A
Sbjct: 1992 SRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEAD 2051
Query: 2269 GLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAEN 2328
G P P+++W L DGS + D G + Y+ + G+L + + G YTC A N
Sbjct: 2052 GQPPPDVAW-LKDGSPL-----GQDMGPHLRFYL--DGGSLVLKGLRASDAGAYTCVAHN 2103
Query: 2329 QVGKDEMRVRVKVVTAPATIR---NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTN 2385
G+D R+ V P TI+ + + V P G++VT+ C +G P V+WL
Sbjct: 2104 PAGED-ARLHTVNVLVPPTIKQGADGSGTLVSRP-GELVTMVCPVRGSPPIHVSWLK-DG 2160
Query: 2386 KVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKIN-- 2443
+P S TL I K Q +D+G +TC+ + AG + + V V PP +
Sbjct: 2161 LPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV-PPVLEPV 2219
Query: 2444 GNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSL 2503
N + VR GS + C+A G+P P V W +G L + ++ SL
Sbjct: 2220 EFQNDVVVVR-----GSLVELPCEARGVPLPLVSW-MKDGEPLLSQ------SLEQGPSL 2267
Query: 2504 DIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLN 2563
+ ++ DS C+A +E GEAR QLTV+EP P +T G + L
Sbjct: 2268 QLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT--PGAPMELL 2325
Query: 2564 CSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYH--KADGMLHISGLSSVDAGAYRCVARNA 2621
C A GTP P++ W + GQ L R + +A +L + DAG Y C+A +
Sbjct: 2326 CDAQGTPQPNITW-------HKDGQALTRLENNSRATRVLRVR-----DAGLYTCLAESP 2373
Query: 2622 AGHTERLVSLKVGLKPE--ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSW-----TLP 2674
AG E+ ++V P + +V + G+ L L C+ + +W L
Sbjct: 2374 AGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQ 2432
Query: 2675 NGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPR 2734
H + P+ GR L ++ S D G Y C G + + V I P
Sbjct: 2433 EDAHTQFPER-GRF-------LQLQALSTADSGDYSCTARNAAGSTSVAFRV-EIHTVPT 2483
Query: 2735 ITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRF-LHPQG 2793
I S P P + T L C A G+P ++W K V RF + P+G
Sbjct: 2484 IRSGP-PAVNVSVNQTALLPCQADGVPAPLVSWR-------KDRVPLDPRSPRFEILPEG 2535
Query: 2794 SLTIQHATQRDAGFYKCMAKNILGSD 2819
SL IQ +DAG Y C+A N GSD
Sbjct: 2536 SLRIQPVLAQDAGHYLCLASNSAGSD 2561
Score = 284 bits (726), Expect = 1e-75
Identities = 270/935 (28%), Positives = 394/935 (42%), Gaps = 89/935 (9%)
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMEC 1972
L I KV ++D G Y C A+NL G + V L V V P + + V ++ +EC
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLV--PPNIEPGPVNKAVLENASVTLEC 716
Query: 1973 LAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAG 2032
LA G P P +SW + Q VS G + R L I++A SD G Y+CVASN AG
Sbjct: 717 LASGVPPPDVSWF----KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 772
Query: 2033 ADSLAIRLHVAALPPVIHQEKLENISLPPGL--------SIHIHCTAKAAPLPSVRWVLG 2084
+ L L V P I+LPP L + + C A AP P++ W L
Sbjct: 773 STELRYGLRVNVPP---------RITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMW-LK 822
Query: 2085 DGTQIRPSQFLHGNLFVFPNG-TLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
DG + P+ L VFP G L + + DSGRY CVA + VG R+ V L V
Sbjct: 823 DGNPVSPAG--TPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPP 880
Query: 2144 ANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILW---RLPSKRMIDALFSFDSRIKV 2200
+ I G V ++ L+C + P P + W P + S D +
Sbjct: 881 S---ILG-EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL-- 934
Query: 2201 FANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGD 2260
L V DAG Y C A N+ G ++V + P +E + V G
Sbjct: 935 -----LQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPV-FPLRESHTLTVREGHP 988
Query: 2261 LKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEG 2320
+ C G+P P+ISW DG Q G ++V LY + + +EG
Sbjct: 989 TSLSCECRGVPFPKISWR-KDG-------QPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 1040
Query: 2321 DYTCFAENQVGKDEMRVRVKVVTAPATI-RNKTYLAVQVPYGDVVTVACEAKGEPMPKVT 2379
YTC N VG ++++V P + V V V T+ C A G+P P VT
Sbjct: 1041 TYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVT 1100
Query: 2380 WLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP 2439
W V + Q Q +L +++AQ + +G Y+C+ N AG + + V V P
Sbjct: 1101 WERDGQPVGAELGLQLQ-NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLV-P 1158
Query: 2440 PKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHG 2499
P++ G+ +P+T + AA S + C+A GIP P + W E V P + + G
Sbjct: 1159 PELIGDLDPLTNI--TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGE---DTYLLAG 1213
Query: 2500 NGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHT 2559
L + ++ DS C+A NE GEAR + VL P I ++ + E I + G T
Sbjct: 1214 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP--PSIENEDLEEVIKVLDGQT 1271
Query: 2560 ISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADG-MLHISGLSSVDAGAYRCVA 2618
L C+ G P P L W +G L G + DG +L + + AG Y C+A
Sbjct: 1272 AHLMCNVTGHPQPKLTW-FKDGRPLARG---DAHHISPDGVLLQVLQANLSSAGHYSCIA 1327
Query: 2619 RNAAGHTERLVSLKVGLKPE----ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLP 2674
NA G + L V L P A V++ + L C +W +
Sbjct: 1328 ANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW-MK 1386
Query: 2675 NGMHLEGPQTLGRVSLLDNGT--LTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYP 2732
+G E + + LL GT L + A D G Y C + E G +V + V V+ P
Sbjct: 1387 DGAPFEASR---NIQLLP-GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IP 1441
Query: 2733 PRITSEP------TPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGN 2786
P I+ + + T+ +T+ L C + +P I W D + + ++ G
Sbjct: 1442 PSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRW-YKDGQPVTPSSRLQVLGE 1500
Query: 2787 RFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSK 2821
L L IQ D+G Y C+A N+ G D +
Sbjct: 1501 GRL-----LQIQPTQVSDSGRYLCVATNVAGEDDQ 1530
Score = 283 bits (724), Expect = 2e-75
Identities = 266/960 (27%), Positives = 399/960 (41%), Gaps = 91/960 (9%)
Query: 1874 PCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG-TLVIRKVQVQDRGQYMCTASN 1932
PCEA G P P V+W K L + L+ G +L + V D G Y C A +
Sbjct: 2236 PCEARGVPLPLVSWMKDGEPLLS---------QSLEQGPSLQLEAVGAGDSGTYSCVAVS 2286
Query: 1933 LHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAME--CLAKGTPAPQISWIFPDRR 1990
G R L TV +P + Q + L ME C A+GTP P I+W +
Sbjct: 2287 EAGEARRHFQL--TVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQA 2344
Query: 1991 VWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIH 2050
+T EN + + + D G+Y C+A + AGA + R+ V A P ++
Sbjct: 2345 -----------LTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVG 2393
Query: 2051 QEKLENI-SLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRP---SQFLHGNLFVFPNGT 2106
+ L PG + + C+ +A P P + W DG ++ +QF F
Sbjct: 2394 PRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR-DGIVLQEDAHTQFPERGRF------ 2445
Query: 2107 LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKL 2166
L ++ L+ DSG Y C A N GS ++ + + P +V T L
Sbjct: 2446 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPT----IRSGPPAVNVSVNQTALL 2501
Query: 2167 DCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNK 2226
C A G P P + WR L R ++ G+L ++ V +DAG YLC+A N
Sbjct: 2502 PCQADGVPAPLVSWRKDRV----PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2557
Query: 2227 VGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVN 2286
G D + V+ PA I N + L + C A+G P P + W DG ++
Sbjct: 2558 AGSDRQGRDLRVLEPPA-IAPSPSNLTLTAHTPAL-LPCEASGSPKPLVVW-WKDGQKLD 2614
Query: 2287 SFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPA 2346
+Q Y + + L G ++ + C N+VG+ +V V P
Sbjct: 2615 FRLQQG-------AYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 2667
Query: 2347 TIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQ 2406
++T V + V+T C + G P P V+W S + Y++ G L I
Sbjct: 2668 IADDQTDFTVTMMAPVVLT--CHSTGIPAPTVSW-SKAGAQLGARGSGYRVSPSGALEIG 2724
Query: 2407 KAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466
+A +G YTC RNSAG K V++ V P + P+ + V E L+ C
Sbjct: 2725 QALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV-VKPLPSVVRAVAE-----EEVLLPC 2778
Query: 2467 KAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGE 2526
+A GIP P + W EG+ + G V G L I D+ +C+A+N G
Sbjct: 2779 EASGIPRPTITWQ-KEGLNVAT---GVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2834
Query: 2527 ARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQS 2586
A +L V P P+ + + + T H L C A G+P P++ W +G +
Sbjct: 2835 AMGKTRLVVQVP---PVIENGLPDLSTTEGSHAF-LPCKARGSPEPNITWD-KDGQPVSG 2889
Query: 2587 GQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNL 2646
+ +F + G L + L DAG Y C A NA G R V L + + P +
Sbjct: 2890 AEG--KFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 2947
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREA-SVFD 2705
S+ G+ L L C G+ R WT+ + EG VS D G+ R A S D
Sbjct: 2948 -SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG------VSEQDGGSTLQRAAVSRED 3000
Query: 2706 RGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADI 2765
GTYVC E G + ++ + + P + E + G +++L+C+ G P DI
Sbjct: 3001 SGTYVCWAENRVGRT-QAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDI 3059
Query: 2766 TWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYI 2825
W +K G+ R R GSLTI + DAG Y+C+A+N +G K +
Sbjct: 3060 HW-------IKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVIL 3112
Score = 282 bits (722), Expect = 3e-75
Identities = 257/962 (26%), Positives = 402/962 (41%), Gaps = 91/962 (9%)
Query: 1875 CEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH 1934
C G P V+W K ++ T + TL I KVQ+ D G + C A++
Sbjct: 2144 CPVRGSPPIHVSWLKDGLPLPLSQRTLLHG----SGHTLRISKVQLADAGIFTCVAASPA 2199
Query: 1935 GL-DRMVVLLSVTVQQPQIL--ASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV 1991
G+ DR L VQ P +L DV V G + + C A+G P P +SW+
Sbjct: 2200 GVADRNFTL---QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWM------ 2250
Query: 1992 WQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQ 2051
+ P+ + +L + +L ++ D G Y CVA + AG +L V P +
Sbjct: 2251 -KDGEPLLSQ-SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2308
Query: 2052 EKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRN 2111
+ +SL PG + + C A+ P P++ W DG + + N + R
Sbjct: 2309 GQPTELSLTPGAPMELLCDAQGTPQPNITW-HKDGQALTRLE----------NNSRATRV 2357
Query: 2112 LAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITG-TSPRRTDVRYGGTLKLDCSA 2170
L +D+G Y C+A + G+ ++ ++ VQ A I G PR G L L+CS
Sbjct: 2358 LRVRDAGLYTCLAESPAGAIEKSFRVRVQ---APPNIVGPRGPRFVVGLAPGQLVLECSV 2414
Query: 2171 SGDPWPRILW-RLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD 2229
+P P+I W R DA F R + L +++++ D+GDY C ARN G
Sbjct: 2415 EAEPAPKITWHRDGIVLQEDAHTQFPERGRF-----LQLQALSTADSGDYSCTARNAAGS 2469
Query: 2230 DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFM 2289
V +V++ P V + C A G+P P +SW L
Sbjct: 2470 TSVAFRVEIHTVPT--IRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPL----- 2522
Query: 2290 QSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIR 2349
R+ R+ + G+L V ++ G Y C A N G D ++V+ PA
Sbjct: 2523 -----DPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAP 2577
Query: 2350 NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKV-IPTSSEKYQIYQDGTLLIQKA 2408
+ + L + + CEA G P P V W K+ Y++ LL+
Sbjct: 2578 SPSNLTLTA--HTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAP 2635
Query: 2409 QRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKA 2468
DS + C+V N GE + + V+V PP I + T ++ C +
Sbjct: 2636 GPQDSAQFECVVSNEVGEAHRLYQVTVHV-PPTIADDQTDFTVTMMAPV-----VLTCHS 2689
Query: 2469 EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEAR 2528
GIP P V W+ G L A G R++ +G+L+I + + C ARN G A
Sbjct: 2690 TGIPAPTVSWS-KAGAQLGARGSGYRVS--PSGALEIGQALPIHAGRYTCSARNSAGVAH 2746
Query: 2529 LILQLTV-LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSG 2587
+ LTV P+ K P+ + A+A + L C A+G P P++ W G ++ +G
Sbjct: 2747 KHVFLTVQASPVVK-----PLPSVVRAVAEEEVLLPCEASGIPRPTITW-QKEGLNVATG 2800
Query: 2588 QQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLV 2647
Q G L I+ S DAG Y C+A+N+AG L V + P +L
Sbjct: 2801 VSTQVL---PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDL- 2856
Query: 2648 SIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRG 2707
S G LPC G+ + +W +G + G + G+ ++ +G L V+ D G
Sbjct: 2857 STTEGSHAFLPCKARGSPEPNITWD-KDGQPVSGAE--GKFTIQPSGELLVKNLEGQDAG 2913
Query: 2708 TYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITW 2767
TY C E G + + + ++ P T + R G+ + L C A G P I W
Sbjct: 2914 TYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL--RLGDRLWLRCAARGSPTPRIGW 2971
Query: 2768 ELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHA--TQRDAGFYKCMAKNILGSDSKTTYI 2825
+ D+ + GV + G T+Q A ++ D+G Y C A+N +G +++
Sbjct: 2972 TVNDRP-VTEGVSEQ---------DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 3021
Query: 2826 HV 2827
HV
Sbjct: 3022 HV 3023
Score = 270 bits (690), Expect = 1e-71
Identities = 230/809 (28%), Positives = 358/809 (44%), Gaps = 83/809 (10%)
Query: 1856 LTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVI 1915
+ P V+V+ + PC+A G P P V+W K + + R RFE+L G+L I
Sbjct: 2484 IRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK----DRVPLDPRSPRFEILPEGSLRI 2539
Query: 1916 RKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAK 1975
+ V QD G Y+C ASN G DR + V +P +A ++T+ + C A
Sbjct: 2540 QPVLAQDAGHYLCLASNSAGSDRQG--RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 2597
Query: 1976 GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS 2035
G+P P + W +++ + +G L + L + D ++CV SN G
Sbjct: 2598 GSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE-- 2653
Query: 2036 LAIRLH--VAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI--RP 2091
A RL+ +PP I ++ + ++ + + C + P P+V W G Q+ R
Sbjct: 2654 -AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVVLTCHSTGIPAPTVSWSKA-GAQLGARG 2710
Query: 2092 SQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGT 2151
S + V P+G L I P +GRY C A N G A + V L VQ + +
Sbjct: 2711 SGYR-----VSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP----VVKP 2761
Query: 2152 SPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSV 2211
P + L C ASG P P I W+ + + + +V G L +
Sbjct: 2762 LPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQLRIAHA 2816
Query: 2212 TDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLP 2271
+ +DAG+YLC+A+N G ++ VV P IE+ D G + C A G P
Sbjct: 2817 SPEDAGNYLCIAKNSAGSAMGKTRL-VVQVPPVIENGLP-DLSTTEGSHAFLPCKARGSP 2874
Query: 2272 NPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG 2331
P I+W DG V+ G ++ + +G L + ++ G YTC AEN VG
Sbjct: 2875 EPNITWD-KDGQPVS---------GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG 2924
Query: 2332 KDEMRVRVKVVTAP--ATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIP 2389
+ RV + ++ P T+ L + GD + + C A+G P P++ W V
Sbjct: 2925 RARRRVHLTILVLPVFTTLPGDRSLRL----GDRLWLRCAARGSPTPRIGWTVNDRPVTE 2980
Query: 2390 TSSEKYQIYQDGTLLIQKA--QRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPN 2447
SE QDG +Q+A R DSG Y C N G + ++HV + P + G
Sbjct: 2981 GVSE-----QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK-EAPVLQGEAF 3034
Query: 2448 PITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRS 2507
GGS +L DC G P P + W +G+ L + +++ NGSL I
Sbjct: 3035 SYLVE---PVGGSIQL-DCVVRGDPVPDIHW-IKDGLPLRGSHLRHQLQ---NGSLTIHR 3086
Query: 2508 LRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH-DPISEKITAMAGHTISLNCSA 2566
+ D+ + C+A NE G A+ ++ +L P+F +P + +T +G ++L C A
Sbjct: 3087 TERDDAGRYQCLAENEMGVAK---KVVILVLQSAPVFQVEP--QDMTVRSGDDVALRCQA 3141
Query: 2567 AGTPTPSLVWVLPNGTDLQSGQQL---QRFYHKADGMLHISGLSSVDAGAYRCVARNAAG 2623
G PTP++ W LQ+GQ L +R DG L + + + DAG Y CVA N G
Sbjct: 3142 TGEPTPTIEW-------LQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLG 3194
Query: 2624 HTERLVSLKVGLKPEANKQYHNLVSIING 2652
L V +P+ + + ++ +ING
Sbjct: 3195 SATARAFLVVRGEPQGS--WGSMTGVING 3221
Score = 267 bits (682), Expect = 1e-70
Identities = 265/1013 (26%), Positives = 414/1013 (40%), Gaps = 93/1013 (9%)
Query: 1853 PQILTKSPQTVSVTA--ETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
P+++ ++TA + CEA G P P + W + +T + L
Sbjct: 1159 PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYL-----LAG 1213
Query: 1911 GTLV-IRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYL-GDTI 1968
G ++ + + Q QD G Y C ASN G R + V V P I ++V L G T
Sbjct: 1214 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP-PSIENEDLEEVIKVLDGQTA 1272
Query: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS 2028
+ C G P P+++W F D R ++ + + L + +A+ S G Y C+A+
Sbjct: 1273 HLMCNVTGHPQPKLTW-FKDGR---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAA 1328
Query: 2029 NAAGADSLAIRLHVAALPPVI---HQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD 2085
NA G + +L V P ++ E +++ I + C A A P P++ W + D
Sbjct: 1329 NAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW-MKD 1387
Query: 2086 GTQIRPSQFLHGNLFVFPNGT--LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
G S+ N+ + P GT L I N +D+G+Y CV N +G A + + V
Sbjct: 1388 GAPFEASR----NIQLLP-GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 1442
Query: 2144 ANAR---ITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV 2200
+ ++ + + + TL L+C + P P I W + + + SR++V
Sbjct: 1443 SISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS-----SRLQV 1497
Query: 2201 FANGTLV-VKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPA-----------KIEHK 2248
G L+ ++ D+G YLCVA N G+D V + + P +I +
Sbjct: 1498 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSR 1557
Query: 2249 EENDH-------KVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
EE ++ + C +P P+++W D L S GGR
Sbjct: 1558 EEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRV--- 1614
Query: 2302 VVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA--VQVP 2359
L V G Y+C A N+VG+D + + V+T P + + L V V
Sbjct: 1615 -------LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVN 1667
Query: 2360 YGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTC 2418
V++ C A G P+P ++WL N + + S + Q+ +DG +L + A+ +D+ +Y C
Sbjct: 1668 ASSTVSLQCPALGNPVPTISWLQ--NGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMC 1725
Query: 2419 LVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLW 2478
+ N AG K + V V PP+I G + + A S + C P P V W
Sbjct: 1726 VAENQAGSAEKLFTLRVQV-PPRIAG----LDLEQVTAILNSSVSLPCDVHAHPNPEVTW 1780
Query: 2479 AFPEGVVLPAPYYGNRI-TVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLE 2537
+ + L G + + G +L + R SDS C A N G + ++QL+VL
Sbjct: 1781 -YKDSQALSL---GEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1836
Query: 2538 PMEKPIFHDPI---SEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFY 2594
P P F + + G L+C P P++ W +G L Q+ Q
Sbjct: 1837 P---PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWY-KDGQPLVLAQRTQAL- 1891
Query: 2595 HKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGET 2654
+ L I D G Y C N AG R +L V + P VS + G
Sbjct: 1892 -RGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSP 1950
Query: 2655 LKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRME 2714
L L C G +W L + M +E G VS G L + GTY C E
Sbjct: 1951 LVLTCDVSGVPAPTVTW-LKDRMPVESSAVHGVVSR--GGRLQLSRLQPAQAGTYTCVAE 2007
Query: 2715 TEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSH 2774
+ V V+ P +S + G V+L+C A G P D+ W L D S
Sbjct: 2008 NTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW-LKDGSP 2066
Query: 2775 LKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
L + L RF GSL ++ DAG Y C+A N G D++ ++V
Sbjct: 2067 LGQDMGPHL---RFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNV 2116
Score = 263 bits (672), Expect = 2e-69
Identities = 263/1011 (26%), Positives = 404/1011 (39%), Gaps = 116/1011 (11%)
Query: 1853 PQIL--TKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
PQI + P VSV + C ATGKP P VTW + ++Q +
Sbjct: 1065 PQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN----QG 1120
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILAS--HYQDVTVYLGDTI 1968
+L + + Q G+Y C A NL G LSV V P+++ ++T L +
Sbjct: 1121 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVP-PELIGDLDPLTNITAALHSPL 1179
Query: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS 2028
+ C A G P P I W R + VSP E L L + + D G+Y C+AS
Sbjct: 1180 TLLCEAMGIPPPAIRWF----RGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 1235
Query: 2029 NAAGADSLAIRLHVAALPPVIHQEKLEN-ISLPPGLSIHIHCTAKAAPLPSVRWVLGDGT 2087
N AG + V +PP I E LE I + G + H+ C P P + W DG
Sbjct: 1236 NEAGEARRNFSVEV-LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTW-FKDGR 1293
Query: 2088 QIRPSQFLHGNLFVFPNGT-LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANA 2146
+ H + P+G L + +G Y C+AAN VG + QL+V A
Sbjct: 1294 PLARGDAHH----ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT-- 1347
Query: 2147 RITGTSPRRTD----VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFA 2202
I G + D V + L C A P P I W M D SR
Sbjct: 1348 -ILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW------MKDGAPFEASRNIQLL 1400
Query: 2203 NGT--LVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPA-----KIEHKEENDHKV 2255
GT L + + +DAG Y CV N++G+ V+V++ P+ + + K
Sbjct: 1401 PGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKT 1460
Query: 2256 FYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG-TLYFNEV 2314
L ++C + +P P I W DG V + R V G L
Sbjct: 1461 KVNSTLTLECESWAVPPPTIRW-YKDGQPVTP----------SSRLQVLGEGRLLQIQPT 1509
Query: 2315 GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAV-------------QVPYG 2361
+ + G Y C A N G+D+ V + P + + A Y
Sbjct: 1510 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1569
Query: 2362 DVVT-----VACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGN 2415
++V + C+ P P +TW + ++ ++ + Q G +L I + ++G
Sbjct: 1570 EIVENNPAYLYCDTNAIPPPDLTWYREDQPL--SAGDEVSVLQGGRVLQIPLVRAENAGR 1627
Query: 2416 YTCLVRNSAGEDRKTVWIHVN---VQPPKINGNPNPITTVREIAAGGSRKL-IDCKAEGI 2471
Y+C N GED W+H + PP I G+ + V E+ S + + C A G
Sbjct: 1628 YSCKASNEVGED----WLHYELLVLTPPVILGDTEEL--VEEVTVNASSTVSLQCPALGN 1681
Query: 2472 PTPRVLWAFPEGVVLPAPYYGNRITVHGNGS-LDIRSLRKSDSVQLVCMARNEGGEARLI 2530
P P + W P+P R+ V +G L + + +D+ +C+A N+ G A +
Sbjct: 1682 PVPTISWLQNGLPFSPSP----RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKL 1737
Query: 2531 LQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQL 2590
L V P P E++TA+ ++SL C P P + W + L G+++
Sbjct: 1738 FTLRVQVP---PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTW-YKDSQALSLGEEV 1793
Query: 2591 QRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP---EANKQYHNLV 2647
F L + D+G Y C A NAAG ++LV L V + P +A + + V
Sbjct: 1794 --FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAV 1851
Query: 2648 SIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNG-TLTVREASVFDR 2706
+ G+ L C + +W +G L Q R L G L ++EA V D+
Sbjct: 1852 LVRVGDKAVLSCETDALPEPTVTW-YKDGQPLVLAQ---RTQALRGGQRLEIQEAQVSDK 1907
Query: 2707 GTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADIT 2766
G Y C++ G +V + + + PP + T + G+ + L C G+P +T
Sbjct: 1908 GLYSCKVSNVAGEAVRTF-TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVT 1966
Query: 2767 W---ELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKN 2814
W +P +S GV +R G L + AG Y C+A+N
Sbjct: 1967 WLKDRMPVESSAVHGVVSR---------GGRLQLSRLQPAQAGTYTCVAEN 2008
Score = 249 bits (635), Expect = 4e-65
Identities = 259/1018 (25%), Positives = 417/1018 (40%), Gaps = 86/1018 (8%)
Query: 1836 FFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFP--CEATGKPKPFVTWTKVSTG 1893
F G A F P + S +T V D + CEA G P P +TW K G
Sbjct: 292 FSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFK--DG 349
Query: 1894 ALMTPNTRIQRFEVLKNG--TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQ 1951
AL+ +T++ V G L + + Q D G Y C ASN G L V V P
Sbjct: 350 ALLPTSTKV----VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVP-PT 404
Query: 1952 ILASHYQDVTV--YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRT 2009
I + + V G +A+EC+A+G P+P +SW V ++ E R+ +
Sbjct: 405 IEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESN---ESRLET-DGSV 460
Query: 2010 LSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHC 2069
L ++ + G+Y CVAS+ AG L + V P ++ E L ++ G + + C
Sbjct: 461 LRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 520
Query: 2070 TAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVG 2129
A +P+P+++W+ RP++ L G TL+I ++ SG + C A N G
Sbjct: 521 QASGSPVPTIQWLQNG----RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 576
Query: 2130 SARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRL-PSKRMI 2188
+A V+++V A + + +G A+ DP W P ++
Sbjct: 577 TAGAEVEVSVHGEWAPGVLEVPIGQ---YHWGXEHHSSFPAACDPPVHRGWGAHPKPPLV 633
Query: 2189 D------ALFSFDSRIKVFAN--GTLVVKSVTDKDAGDYLCVARNKVGDD--YVVLKVDV 2238
+ +L+ + I V + L ++ V +D G Y C A N G+ V LK
Sbjct: 634 EGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALK--- 690
Query: 2239 VMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRT 2298
V+ P IE N V + ++C+A+G+P P++SW V+S+M G T
Sbjct: 691 VLVPPNIEPGPVN-KAVLENASVTLECLASGVPPPDVSW-FKGHQPVSSWM------GVT 742
Query: 2299 KRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQV 2358
V + L + + + G Y C A N G E+R ++ V P I L V
Sbjct: 743 ---VSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLR-VNVPPRITLPPSLPGPV 798
Query: 2359 PYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYT 2417
V + C A G P P + WL N V P + Q++ G +L + A+ SDSG Y+
Sbjct: 799 LVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYS 858
Query: 2418 CLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVL 2477
C+ ++ GEDR+ V + V++ PP I G ++ V + ++C++ +P P +
Sbjct: 859 CVAVSAVGEDRQDVVLQVHM-PPSILGEELNVSVVANESVA-----LECQSHAMPPPVLS 912
Query: 2478 WAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLE 2537
W + P P G ++ L + D+ C A N+ G + L V
Sbjct: 913 WWKDGRPLEPRP--GVHLSA-DKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNV-- 967
Query: 2538 PMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKA 2597
P+F S +T GH SL+C G P P + W +G L +
Sbjct: 968 -WVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISW-RKDGQPLPGEGAGLQHVSAV 1025
Query: 2598 DGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPE--ANKQYHNLVSIINGETL 2655
+L++ G Y C N G++ + + L+V + P+ ++ VS++
Sbjct: 1026 GRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA 1085
Query: 2656 KLPCTPPGAGQGRFSWT---LPNGMHLEGPQTLGRVSLLDNG-TLTVREASVFDRGTYVC 2711
L C G +W P G L + L + G +L V A G Y C
Sbjct: 1086 TLECNATGKPPPTVTWERDGQPVGAEL-------GLQLQNQGQSLHVERAQAAHTGRYSC 1138
Query: 2712 RMETEYGPSVTSIPVIVIAYPPRITSEPTPV--IYTRPGNTVKLNCMAMGIPKADITWEL 2769
E G + + V+ PP + + P+ I + + L C AMGIP I W
Sbjct: 1139 VAENLAGRAERKFELSVLV-PPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW-F 1196
Query: 2770 PDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ + G L ++ L + ++D+G Y C+A N G + + V
Sbjct: 1197 RGEEPVSPGEDTYLLAGGWM-----LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1249
Score = 246 bits (627), Expect = 3e-64
Identities = 235/910 (25%), Positives = 368/910 (40%), Gaps = 79/910 (8%)
Query: 1858 KSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRK 1917
+ P+ V A V C +P P +TW + G ++ + Q E + L ++
Sbjct: 2395 RGPRFVVGLAPGQLVLECSVEAEPAPKITWHR--DGIVLQEDAHTQFPE--RGRFLQLQA 2450
Query: 1918 VQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGT 1977
+ D G Y CTA N G V V + + S V V + T + C A G
Sbjct: 2451 LSTADSGDYSCTARNAAGSTS--VAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 2508
Query: 1978 PAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLA 2037
PAP +SW R+ + P R + +L I+ D G Y C+ASN+AG+D
Sbjct: 2509 PAPLVSW----RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQG 2564
Query: 2038 IRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHG 2097
L V PP I N++L + C A +P P V W DG ++ + G
Sbjct: 2565 RDLRVLE-PPAIAPSP-SNLTLTAHTPALLPCEASGSPKPLVVW-WKDGQKL-DFRLQQG 2620
Query: 2098 NLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTD 2157
+ P+ L + P+DS ++ECV +N VG A R Q+ V A +TD
Sbjct: 2621 AYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIA------DDQTD 2674
Query: 2158 --VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKD 2215
V + L C ++G P P + W + L + S +V +G L +
Sbjct: 2675 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ----LGARGSGYRVSPSGALEIGQALPIH 2730
Query: 2216 AGDYLCVARNKVG----DDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLP 2271
AG Y C ARN G ++ ++ V+KP + + +V + C A+G+P
Sbjct: 2731 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVL------LPCEASGIP 2784
Query: 2272 NPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG 2331
P I+W +G V + + + V G L + G+Y C A+N G
Sbjct: 2785 RPTITWQ-KEGLNVATGVSTQ----------VLPGGQLRIAHASPEDAGNYLCIAKNSAG 2833
Query: 2332 KDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTS 2391
+ R+ VV P I N + G + C+A+G P P +TW + + +
Sbjct: 2834 SAMGKTRL-VVQVPPVIENGLP-DLSTTEGSHAFLPCKARGSPEPNITW-DKDGQPVSGA 2890
Query: 2392 SEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITT 2451
K+ I G LL++ + D+G YTC N+ G R+ V + + V P TT
Sbjct: 2891 EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPV--------FTT 2942
Query: 2452 V---REIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSL 2508
+ R + G R + C A G PTPR+ W V P G +L ++
Sbjct: 2943 LPGDRSLRLG-DRLWLRCAARGSPTPRIGWT-----VNDRPVTEGVSEQDGGSTLQRAAV 2996
Query: 2509 RKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAG 2568
+ DS VC A N G + + + + E P+ + G +I L+C G
Sbjct: 2997 SREDSGTYVCWAENRVGRTQAV---SFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRG 3053
Query: 2569 TPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERL 2628
P P + W+ +G L+ G L+ + +G L I DAG Y+C+A N G +++
Sbjct: 3054 DPVPDIHWI-KDGLPLR-GSHLR--HQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKV 3109
Query: 2629 VSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRV 2688
V L + P + ++ ++ +G+ + L C G W L G L + R+
Sbjct: 3110 VILVLQSAPVFQVEPQDM-TVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRASR---RL 3164
Query: 2689 SLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPG 2748
L +G+L + D GTY C G + ++V P T VI R
Sbjct: 3165 RTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKF 3224
Query: 2749 NTVKLNCMAM 2758
LN M
Sbjct: 3225 GVATLNTSVM 3234
Score = 241 bits (615), Expect = 7e-63
Identities = 271/1002 (27%), Positives = 407/1002 (40%), Gaps = 87/1002 (8%)
Query: 1842 PASKFWSLGEKPQIL-TKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALM-TPN 1899
P +S P +L + Q V A D C +G P P V WTK L P+
Sbjct: 205 PTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPH 264
Query: 1900 TRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQD 1959
++Q L I V D G+Y C A + G L V ++ +
Sbjct: 265 LQVQE----DGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGE 320
Query: 1960 VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSD 2019
V V + + C A+G P P I+W F D + T + V + R L + A SD
Sbjct: 321 VAVMEDHLVQLLCEARGVPTPNITW-FKDGALLPTSTKV---VYTRGGRQLQLGRAQSSD 376
Query: 2020 RGVYKCVASNAAGADSLAIRLHVAALPPVIHQE--KLENISLPPGLSIHIHCTAKAAPLP 2077
GVY C ASNA GA A RL V +PP I + + G + + C A+ P P
Sbjct: 377 AGVYTCKASNAVGAAEKATRLDV-YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSP 435
Query: 2078 SVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQL 2137
++ W +G + S + + L + + SG Y CVA++ G A +Q
Sbjct: 436 TLSW-HHEGLPVAES---NESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA--VLQY 489
Query: 2138 NVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSR 2197
+V+ + + G L+L C ASG P P I W L + R + L +
Sbjct: 490 SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW-LQNGRPAEEL----AG 544
Query: 2198 IKVFANG-TLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDV--VMKPAKIEHKEENDHK 2254
++V + G TL + V +G + C A N+ G ++V V P +E H
Sbjct: 545 VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYH- 603
Query: 2255 VFYGGDLKVDCVATGLPNPEISWSL-PDGSLVNSFMQSDDSGGRTKRYVVFNN--GTLYF 2311
+G + A P W P LV + G V + L
Sbjct: 604 --WGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQI 661
Query: 2312 NEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAK 2371
+V +R+EG YTC A N G+ + V +KV+ P AV VT+ C A
Sbjct: 662 EKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVL--ENASVTLECLAS 719
Query: 2372 GEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKT 2430
G P P V+W V +S + DG +L I++AQ SD+G+Y C+ N AG
Sbjct: 720 GVPPPDVSWFKGHQPV--SSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELR 777
Query: 2431 VWIHVNVQPPKIN---GNPNPI---TTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGV 2484
+ VNV PP+I P P+ T VR + C A G P+P ++W
Sbjct: 778 YGLRVNV-PPRITLPPSLPGPVLVNTPVR----------LTCNATGAPSPTLMWLKDGNP 826
Query: 2485 VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF 2544
V PA G ++ G L + S R SDS + C+A + GE R + L V M I
Sbjct: 827 VSPAGTPGLQV-FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV--HMPPSIL 883
Query: 2545 HDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHIS 2604
+ ++ ++ +A +++L C + P P L W +G L+ + KA +L +
Sbjct: 884 GEELN--VSVVANESVALECQSHAMPPPVLSW-WKDGRPLEPRPGVHLSADKA--LLQVD 938
Query: 2605 GLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGA 2664
DAG Y C A N AG +E+ +L V + P + + +++ G L C G
Sbjct: 939 RADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGV 998
Query: 2665 GQGRFSW-----TLP-NGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYG 2718
+ SW LP G L+ +GR+ L + +A + GTY C G
Sbjct: 999 PFPKISWRKDGQPLPGEGAGLQHVSAVGRL-------LYLGQAQLAQEGTYTCECSNVVG 1051
Query: 2719 PSVTSIPVIVIAYPPRITS--EPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKS-HL 2775
S + + + PP+I EP + L C A G P +TWE +
Sbjct: 1052 NSSQDLQ-LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGA 1110
Query: 2776 KAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILG 2817
+ G+Q + G SL ++ A G Y C+A+N+ G
Sbjct: 1111 ELGLQLQNQGQ-------SLHVERAQAAHTGRYSCVAENLAG 1145
Score = 239 bits (611), Expect = 2e-62
Identities = 279/1086 (25%), Positives = 413/1086 (38%), Gaps = 125/1086 (11%)
Query: 1785 PAPPLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPAS 1844
P PPL+ + GS IP+ S + ++ G + +++ AG
Sbjct: 628 PKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNL-AGESKRE 686
Query: 1845 KFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTK----VST--GALMTP 1898
+ P I P +V C A+G P P V+W K VS+ G ++
Sbjct: 687 VALKVLVPPNI-EPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV 745
Query: 1899 NTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQ 1958
+ R+ R E + Q+ D G Y C ASN+ G + L V V P+I
Sbjct: 746 DGRVLRIE----------QAQLSDAGSYRCVASNVAGSTELRYGLRVNV-PPRITLPPSL 794
Query: 1959 DVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFS 2018
V + + + C A G P+P + W+ V +P G R L++ A S
Sbjct: 795 PGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTP--GLQVFPGGRVLTLASARAS 852
Query: 2019 DRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPS 2078
D G Y CVA +A G D + L V +PP I E+L N+S+ S+ + C + A P P
Sbjct: 853 DSGRYSCVAVSAVGEDRQDVVLQV-HMPPSILGEEL-NVSVVANESVALECQSHAMPPPV 910
Query: 2079 VRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLN 2138
+ W DG + P +H L + D+G Y C A N G + + LN
Sbjct: 911 LSW-WKDGRPLEPRPGVH---LSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLN 966
Query: 2139 VQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR-----LPSKRMIDALFS 2193
V A VR G L C G P+P+I WR LP + S
Sbjct: 967 VWVAPV---FPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVS 1023
Query: 2194 FDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKE-END 2252
R+ L G Y C N VG+ L+++V + P +E
Sbjct: 1024 AVGRLLYLGQAQLA-------QEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQ 1076
Query: 2253 HKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFN 2312
V G ++C ATG P P ++W DG V G + +L+
Sbjct: 1077 VSVVQDGVATLECNATGKPPPTVTWE-RDGQPV---------GAELGLQLQNQGQSLHVE 1126
Query: 2313 EVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA-VQVPYGDVVTVACEAK 2371
G Y+C AEN G+ E + + V+ P I + L + +T+ CEA
Sbjct: 1127 RAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAM 1186
Query: 2372 GEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTV 2431
G P P + W V P + Y + L + + Q DSG Y+CL N AGE R+
Sbjct: 1187 GIPPPAIRWFRGEEPVSP-GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNF 1245
Query: 2432 WIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYY 2491
+ V V P N + + V + G + C G P P++ W F +G L
Sbjct: 1246 SVEVLVPPSIENEDLEEVIKVLD----GQTAHLMCNVTGHPQPKLTW-FKDGRPLAR--- 1297
Query: 2492 GNRITVHGNG-SLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV-LEPMEKPIFHDPIS 2549
G+ + +G L + S + C+A N GE QL+V L P D
Sbjct: 1298 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 1357
Query: 2550 EKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSV 2609
E++T + ISL C A P+P++ W + +G ++ + +Q L I
Sbjct: 1358 EEVTVTVNNPISLICEALAFPSPNITW-MKDGAPFEASRNIQLL--PGTHGLQILNAQKE 1414
Query: 2610 DAGAYRCVARNAAGHTERLVSLKVGLKPEANKQ-------YHNLVSIINGETLKLPCTPP 2662
DAG Y CV N G + ++V + P +K + + +N TL L C
Sbjct: 1415 DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN-STLTLECE-- 1471
Query: 2663 GAGQGRFSWTLPN---GMHLEG-PQT-LGRVSLLDNG-TLTVREASVFDRGTYVCRMETE 2716
SW +P + +G P T R+ +L G L ++ V D G Y+C
Sbjct: 1472 -------SWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 1524
Query: 2717 YGPSVTSIPVIVIAYPPRI----------------------TSEPTPVIYTRPGNTVKLN 2754
G V+ I PP +E ++ P L
Sbjct: 1525 AGEDDQDFNVL-IQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNP---AYLY 1580
Query: 2755 CMAMGIPKADITWELPDKSHLKAGVQAR-LYGNRFLHPQGSLTIQHATQRDAGFYKCMAK 2813
C IP D+TW D+ L AG + L G R L I +AG Y C A
Sbjct: 1581 CDTNAIPPPDLTWYREDQP-LSAGDEVSVLQGGRVLQ------IPLVRAENAGRYSCKAS 1633
Query: 2814 NILGSD 2819
N +G D
Sbjct: 1634 NEVGED 1639
Score = 229 bits (585), Expect = 2e-59
Identities = 190/682 (27%), Positives = 292/682 (42%), Gaps = 62/682 (9%)
Query: 1852 KPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG 1911
+P + SP +++TA T + PCEA+G PKP V W K G + + + +L +
Sbjct: 2571 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK--DGQKLDFRLQQGAYRLLPSN 2628
Query: 1912 TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAME 1971
L++ QD Q+ C SN G L VTV P +A D TV + + +
Sbjct: 2629 ALLLTAPGPQDSAQFECVVSNEVGEAHR--LYQVTVHVPPTIADDQTDFTVTMMAPVVLT 2686
Query: 1972 CLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAA 2031
C + G PAP +SW + + + + L I +A G Y C A N+A
Sbjct: 2687 CHSTGIPAPTVSW----SKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 2742
Query: 2032 GADSLAIRLHVAA------LPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD 2085
G + L V A LP V+ E + LP C A P P++ W +
Sbjct: 2743 GVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLP--------CEASGIPRPTITW-QKE 2793
Query: 2086 GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAAN 2145
G + + V P G L I + +P+D+G Y C+A N GSA +L VQ
Sbjct: 2794 GLNVATGV----STQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV- 2848
Query: 2146 ARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGT 2205
I P + G L C A G P P I W + + A + + + +G
Sbjct: 2849 --IENGLPDLSTTE-GSHAFLPCKARGSPEPNITWDKDGQPVSGA----EGKFTIQPSGE 2901
Query: 2206 LVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDC 2265
L+VK++ +DAG Y C A N VG + + +++ P + D + G L + C
Sbjct: 2902 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP--VFTTLPGDRSLRLGDRLWLRC 2959
Query: 2266 VATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCF 2325
A G P P I W++ D + + D GG TL V + G Y C+
Sbjct: 2960 AARGSPTPRIGWTVNDRPVTEGVSEQD--GG----------STLQRAAVSREDSGTYVCW 3007
Query: 2326 AENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTN 2385
AEN+VG+ + V V AP ++ + + + P G + + C +G+P+P + W+
Sbjct: 3008 AENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIK-DG 3065
Query: 2386 KVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGN 2445
+ S ++Q+ Q+G+L I + +R D+G Y CL N G +K V I V P
Sbjct: 3066 LPLRGSHLRHQL-QNGSLTIHRTERDDAGRYQCLAENEMGVAKKVV-ILVLQSAPVFQVE 3123
Query: 2446 PNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDI 2505
P +T G + C+A G PTP + W G L A R+ +GSL +
Sbjct: 3124 PQDMT-----VRSGDDVALRCQATGEPTPTIEW-LQAGQPLRA---SRRLRTLPDGSLWL 3174
Query: 2506 RSLRKSDSVQLVCMARNEGGEA 2527
++ D+ C+A N G A
Sbjct: 3175 ENVETGDAGTYDCVAHNLLGSA 3196
Score = 215 bits (547), Expect = 6e-55
Identities = 235/912 (25%), Positives = 367/912 (40%), Gaps = 100/912 (10%)
Query: 1950 PQIL-ASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHEN- 2007
P +L A Q+V G + ++C G P PQ+ W DR Q V P + + E+
Sbjct: 216 PSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWT-KDR---QPVLPGGPHLQVQEDG 271
Query: 2008 RTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHI 2067
+ L I + D G Y+CVA + AG + +L V A P + + +++ + +
Sbjct: 272 QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQL 331
Query: 2068 HCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANL 2127
C A+ P P++ W DG + S + ++ L + D+G Y C A+N
Sbjct: 332 LCEARGVPTPNITW-FKDGALLPTSTKV---VYTRGGRQLQLGRAQSSDAGVYTCKASNA 387
Query: 2128 VGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRM 2187
VG+A + +L+V G P G + L+C A G P P + W +
Sbjct: 388 VGAAEKATRLDVY-VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPV 446
Query: 2188 IDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEH 2247
+ S +SR++ L ++S + +G Y CVA + G+ + V+V + P +
Sbjct: 447 AE---SNESRLET-DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVA 502
Query: 2248 KEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG 2307
+ G L++ C A+G P P I W L N + +G + V
Sbjct: 503 EGLGQVTTIVGQPLELPCQASGSPVPTIQW------LQNGRPAEELAGVQ----VASQGT 552
Query: 2308 TLYFNEVGMREEGDYTCFAENQVGK--DEMRVRVKVVTAPATIRNKTYLAVQVPYGDV-- 2363
TL+ + V + G + C A N+ G E+ V V AP + +VP G
Sbjct: 553 TLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVL--------EVPIGQYHW 604
Query: 2364 -------VTVACEAK------GEPMPKVT--WLSPTNKVIPTSSEKYQIYQDGTLLIQKA 2408
AC+ P P + W SP + + L I+K
Sbjct: 605 GXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKV 664
Query: 2409 QRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKA 2468
D G YTC N AGE ++ V + V V PP I P V + + ++C A
Sbjct: 665 DLRDEGIYTCAATNLAGESKREVALKVLV-PPNIEPGP-----VNKAVLENASVTLECLA 718
Query: 2469 EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEAR 2528
G+P P V W +G + + G ++V G L I + SD+ C+A N G
Sbjct: 719 SGVPPPDVSWF--KGHQPVSSWMGVTVSVDGR-VLRIEQAQLSDAGSYRCVASNVAGSTE 775
Query: 2529 LILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQ 2588
L L V P P P S + + L C+A G P+P+L+W+ +G
Sbjct: 776 LRYGLRVNVP---PRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 832
Query: 2589 Q-LQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLV 2647
LQ F +L ++ + D+G Y CVA +A G + V L+V + P + N V
Sbjct: 833 PGLQVF--PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELN-V 889
Query: 2648 SIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRG 2707
S++ E++ L C SW +G LE P+ +S D L V A V+D G
Sbjct: 890 SVVANESVALECQSHAMPPPVLSW-WKDGRPLE-PRPGVHLS-ADKALLQVDRADVWDAG 946
Query: 2708 TYVC-------RMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGI 2760
Y C R E Y +V PV + +T R G+ L+C G+
Sbjct: 947 HYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLT--------VREGHPTSLSCECRGV 998
Query: 2761 PKADITWE-----LPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNI 2815
P I+W LP + AG+Q R L+ + A G Y C N+
Sbjct: 999 PFPKISWRKDGQPLPGEG---AGLQHVSAVGRLLY------LGQAQLAQEGTYTCECSNV 1049
Query: 2816 LGSDSKTTYIHV 2827
+G+ S+ + V
Sbjct: 1050 VGNSSQDLQLEV 1061
Score = 197 bits (501), Expect = 1e-49
Identities = 251/1006 (24%), Positives = 363/1006 (36%), Gaps = 113/1006 (11%)
Query: 1875 CEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH 1934
C G PKP VTW K G P VL+ G+L + V D G Y C A+N
Sbjct: 24 CGTHGTPKPQVTWRK---GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEV 80
Query: 1935 GLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQT 1994
G L V V +V+ G ++ +EC A G P P+I W+ + V
Sbjct: 81 GSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVP 140
Query: 1995 VS-----------PVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS-------- 2035
+ V G L E ++L G A +A +
Sbjct: 141 LGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAG 200
Query: 2036 -----LAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIR 2090
A P V+ + + G + + C P P V W D +
Sbjct: 201 FEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK-DRQPVL 259
Query: 2091 PSQFLHGNLFVFPNG-TLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARIT 2149
P +L V +G L I D GRY+CVA + G R QL V A I
Sbjct: 260 PGG---PHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH---APPTIW 313
Query: 2150 GTSPR-RTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGT-LV 2207
G++ V ++L C A G P P I W AL +++ G L
Sbjct: 314 GSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG-----ALLPTSTKVVYTRGGRQLQ 368
Query: 2208 VKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDH--KVFYGGDLKVDC 2265
+ DAG Y C A N VG ++DV + P IE + K G + ++C
Sbjct: 369 LGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT-IEGAGGRPYVVKAVAGRPVALEC 427
Query: 2266 VATGLPNPEISW---SLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDY 2322
VA G P+P +SW LP S +++D S L G G Y
Sbjct: 428 VARGHPSPTLSWHHEGLPVAESNESRLETDGS-------------VLRLESPGEASSGLY 474
Query: 2323 TCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLS 2382
+C A + G+ ++ V+V P + + V G + + C+A G P+P + WL
Sbjct: 475 SCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQ 534
Query: 2383 PTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQ-PP 2440
+ Q+ GT L I + SG + C N AG V + V+ + P
Sbjct: 535 NGRPAEELAG--VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAP 592
Query: 2441 KINGNPN-------------PITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVV-- 2485
+ P P + G EG +P LW P G+
Sbjct: 593 GVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVA 652
Query: 2486 --LPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPI 2543
LP P L I + D C A N GE++ + L VL P I
Sbjct: 653 YSLPPP-------------LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN--I 697
Query: 2544 FHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADG-MLH 2602
P+++ + A +++L C A+G P P + W + Q DG +L
Sbjct: 698 EPGPVNKAVLENA--SVTLECLASGVPPPDVSWFKGH----QPVSSWMGVTVSVDGRVLR 751
Query: 2603 ISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPP 2662
I DAG+YRCVA N AG TE L+V + P ++ ++L C
Sbjct: 752 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNAT 811
Query: 2663 GAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVT 2722
GA W L +G + T G LT+ A D G Y C + G
Sbjct: 812 GAPSPTLMW-LKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQ 870
Query: 2723 SIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQAR 2782
+ V+ + PP I E V +V L C + +P ++W D L+
Sbjct: 871 DV-VLQVHMPPSILGEELNVSVVA-NESVALECQSHAMPPPVLSW-WKDGRPLEPRPGVH 927
Query: 2783 LYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHVF 2828
L ++ L L + A DAG Y C A N G K ++V+
Sbjct: 928 LSADKAL-----LQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVW 968
Score = 183 bits (464), Expect = 2e-45
Identities = 224/925 (24%), Positives = 356/925 (38%), Gaps = 119/925 (12%)
Query: 1964 LGD---TIAME---CLAKGTPAPQISWIFPDRRVWQTVSPVEGR--ITLHENRTLSIKEA 2015
LGD T+ +E C GTP PQ++W R + P+ G+ + + E +L +
Sbjct: 10 LGDVALTVGLEAGGCGTHGTPKPQVTW-----RKGPSSEPLHGQPGVAVLEEGSLFLASV 64
Query: 2016 SFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAP 2075
S +D G Y+C A+N G+ S +L V P + + N+S G S+ + C A P
Sbjct: 65 SPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFP 124
Query: 2076 LPSVRWV------------LGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECV 2123
+P + W+ G G + Q + G+ + +L+ + P SGR
Sbjct: 125 VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQ-VGGHRLLDEGQSLHFPRIQPGRSGRRGAQ 183
Query: 2124 A-----------ANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASG 2172
A A L G + A + + + + G ++L C SG
Sbjct: 184 AGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSG 243
Query: 2173 DPWPRILWRLPSKRMIDALFSFDSRIKVFANG-TLVVKSVTDKDAGDYLCVARNKVGDDY 2231
P P++ W + ++ ++V +G L + D G Y CVA + G
Sbjct: 244 VPTPQVEWTKDRQPVLPG----GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQA 299
Query: 2232 VVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQS 2291
++ V P E + V +++ C A G+P P I+W DG+L+
Sbjct: 300 RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW-FKDGALL------ 352
Query: 2292 DDSGGRTKRYVVFNNG--TLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPAT-- 2347
T VV+ G L + G YTC A N VG E R+ V P
Sbjct: 353 -----PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEG 407
Query: 2348 IRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTS-SEKYQIYQDGTLL-I 2405
+ Y+ V+ G V + C A+G P P ++W ++ +P + S + ++ DG++L +
Sbjct: 408 AGGRPYV-VKAVAGRPVALECVARGHPSPTLSW---HHEGLPVAESNESRLETDGSVLRL 463
Query: 2406 QKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNP-NPITTVREIAAGGSRKLI 2464
+ + SG Y+C+ + AGE + V V P + +TT+ G +
Sbjct: 464 ESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTI-----VGQPLEL 518
Query: 2465 DCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEG 2524
C+A G P P + W G PA +L I + S C A NE
Sbjct: 519 PCQASGSPVPTIQW-LQNG--RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 575
Query: 2525 GEARLILQLTVLEPMEKPIFHDPISEKITAMAGH-TISLNCS---------------AAG 2568
G A ++++V + PI + H + C G
Sbjct: 576 GTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEG 635
Query: 2569 TPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERL 2628
+P +W P G + + L I + D G Y C A N AG ++R
Sbjct: 636 WCSPGSLWGEPTGIPVA---------YSLPPPLQIEKVDLRDEGIYTCAATNLAGESKRE 686
Query: 2629 VSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRV 2688
V+LKV + P N +++ ++ L C G SW H +G
Sbjct: 687 VALKVLVPPNIEPGPVN-KAVLENASVTLECLASGVPPPDVSWFKG---HQPVSSWMGVT 742
Query: 2689 SLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRIT---SEPTPVIYT 2745
+D L + +A + D G+Y C G + + + PPRIT S P PV+
Sbjct: 743 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-LRVNVPPRITLPPSLPGPVLVN 801
Query: 2746 RPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLH--PQGS-LTIQHATQ 2802
P V+L C A G P + W LK G G L P G LT+ A
Sbjct: 802 TP---VRLTCNATGAPSPTLMW-------LKDGNPVSPAGTPGLQVFPGGRVLTLASARA 851
Query: 2803 RDAGFYKCMAKNILGSDSKTTYIHV 2827
D+G Y C+A + +G D + + V
Sbjct: 852 SDSGRYSCVAVSAVGEDRQDVVLQV 876
Score = 80.9 bits (198), Expect = 2e-14
Identities = 66/198 (33%), Positives = 92/198 (46%), Gaps = 12/198 (6%)
Query: 477 VMIEP---SGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFS 533
V++ P S V R+ VLEG +L C P + W L DGS L M P +F
Sbjct: 2021 VLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW-LKDGSPLGQDMG-PHLRF- 2077
Query: 534 ILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKD-TVTIGKNPG 592
L G L +K + SD+G Y C+A D ++ V V P T D + T+ PG
Sbjct: 2078 YLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2137
Query: 593 ESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCV 652
E VT+ C P H+SW+ + H TL I KVQ++D+G + CV
Sbjct: 2138 ELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHG---SGHTLRISKVQLADAGIFTCV 2194
Query: 653 AVNQQG-AD-HFTVGITV 668
A + G AD +FT+ + V
Sbjct: 2195 AASPAGVADRNFTLQVQV 2212
Score = 68.2 bits (165), Expect = 1e-10
Identities = 49/166 (29%), Positives = 75/166 (45%), Gaps = 12/166 (7%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLY 553
GG QL C V+ P I W+ DG L+ L +G L I E D+G Y
Sbjct: 3042 GGSIQLDCVVRGDPVPDIHWI-KDGLPLRG-----SHLRHQLQNGSLTIHRTERDDAGRY 3095
Query: 554 QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWIL 613
QC+A+ + + V +++QS E +T+ G+ V L C A P + W+
Sbjct: 3096 QCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTV--RSGDDVALRCQATGEPTPTIEWLQ 3153
Query: 614 PNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
+ L + + LP+G+L + V+ D+G Y CVA N G+
Sbjct: 3154 AGQ----PLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGS 3195
Score = 66.6 bits (161), Expect = 3e-10
Identities = 49/169 (28%), Positives = 83/169 (49%), Gaps = 10/169 (5%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSG 551
L G L C+V+A +P I W DG +L+ +D ++F +L+++++ +DSG
Sbjct: 2403 LAPGQLVLECSVEAEPAPKITWHR-DGIVLQ---EDAHTQFPERGR-FLQLQALSTADSG 2457
Query: 552 LYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSW 611
Y C A+ + +RV + + T + V + N ++ LPC A +P +SW
Sbjct: 2458 DYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSW 2515
Query: 612 ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD 660
R+ D + +LP G+L I V D+G+Y C+A N G+D
Sbjct: 2516 --RKDRVPLD-PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 2561
Score = 66.2 bits (160), Expect = 4e-10
Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 14/182 (7%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSD 549
VL P +L+CN + SP++ W L DG+ + +P P + G L + S SD
Sbjct: 798 VLVNTPVRLTCNATGAPSPTLMW-LKDGNPV-SPAGTPG--LQVFPGGRVLTLASARASD 853
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHL 609
SG Y C+A DR + V P + E+ V++ N ESV L C + A+P L
Sbjct: 854 SGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVAN--ESVALECQSHAMPPPVL 911
Query: 610 SWILPNRRIINDLANTSHVYM-LPNGTLSIPKVQVSDSGYYRCVAVNQQGAD--HFTVGI 666
SW R L V++ L + + V D+G+Y C A+NQ G H+ + +
Sbjct: 912 SWWKDGR----PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNV 967
Query: 667 TV 668
V
Sbjct: 968 WV 969
Score = 63.2 bits (152), Expect = 4e-09
Identities = 44/141 (31%), Positives = 68/141 (48%), Gaps = 22/141 (15%)
Query: 2048 VIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGN--LFVFPNG 2105
V+ + L +++L GL C P P V W G S+ LHG + V G
Sbjct: 4 VLEIKGLGDVALTVGLEAG-GCGTHGTPKPQVTWRKGPS-----SEPLHGQPGVAVLEEG 57
Query: 2106 TLYIRNLAPKDSGRYECVAANLVGSARRTVQL------NVQRAAANARITGTSPRRTDVR 2159
+L++ +++P DSG YEC A N VGS R +L +++ A ++G +
Sbjct: 58 SLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMA------- 110
Query: 2160 YGGTLKLDCSASGDPWPRILW 2180
G +L L+C A+G P P I+W
Sbjct: 111 -GQSLTLECDANGFPVPEIVW 130
Score = 63.2 bits (152), Expect = 4e-09
Identities = 55/205 (26%), Positives = 92/205 (44%), Gaps = 22/205 (10%)
Query: 480 EPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG- 538
E G V + ++E P L C+ A P + W D P+ D + S+L G
Sbjct: 1560 EARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED-----QPLSAGD-EVSVLQGGR 1613
Query: 539 WLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVT--IGKNPGESVT 596
L+I + ++G Y C A D + Y +LV +P + + + + N +V+
Sbjct: 1614 VLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVS 1673
Query: 597 LPCNALAIPEAHLSWI---LPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCV 652
L C AL P +SW+ LP + + + +L +G L + +V+D+ Y CV
Sbjct: 1674 LQCPALGNPVPTISWLQNGLP-------FSPSPRLQVLEDGQVLQVSTAEVADAASYMCV 1726
Query: 653 AVNQQGADH--FTVGITVTKKGSGL 675
A NQ G+ FT+ + V + +GL
Sbjct: 1727 AENQAGSAEKLFTLRVQVPPRIAGL 1751
Score = 63.2 bits (152), Expect = 4e-09
Identities = 57/222 (25%), Positives = 99/222 (44%), Gaps = 15/222 (6%)
Query: 477 VMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILS 536
V++ + + + TV L C + P+I W L +G P + +L
Sbjct: 1652 VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW-LQNGLPFS-----PSPRLQVLE 1705
Query: 537 SGW-LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESV 595
G L++ + E +D+ Y C+A+ + ++ + VQ P + A D + SV
Sbjct: 1706 DGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPP-RIAGLDLEQVTAILNSSV 1764
Query: 596 TLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAV 654
+LPC+ A P ++W ++ L+ V++LP TL + + ++SDSG Y C A+
Sbjct: 1765 SLPCDVHAHPNPEVTWYKDSQA----LSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEAL 1820
Query: 655 NQQGADHFTVGITVTKKGSGLPSKRGRRPGAKALSRVREDIV 696
N G D V ++V + + RG P L RV + V
Sbjct: 1821 NAAGRDQKLVQLSVLVPPAFRQAPRG--PQDAVLVRVGDKAV 1860
Score = 61.6 bits (148), Expect = 1e-08
Identities = 55/219 (25%), Positives = 96/219 (43%), Gaps = 21/219 (9%)
Query: 477 VMIEPSGAVQRDQTVLE--GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSI 534
V + P+ + +TV + G P L+C+V +P++ W+ + P++ +
Sbjct: 1929 VQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKD-----RMPVESSAVHGVV 1983
Query: 535 LSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLV----QSPSTQPAEKDTVTIGKN 590
G L++ ++P+ +G Y C+A+ R + V V + S+ A + V
Sbjct: 1984 SRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVL---- 2039
Query: 591 PGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYR 650
G+ V L C A P ++W+ + D+ Y L G+L + ++ SD+G Y
Sbjct: 2040 EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY-LDGGSLVLKGLRASDAGAYT 2098
Query: 651 CVAVNQQGADH--FTVGITV---TKKGSGLPSKRGRRPG 684
CVA N G D TV + V K+G+ RPG
Sbjct: 2099 CVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2137
Score = 61.2 bits (147), Expect = 1e-08
Identities = 51/202 (25%), Positives = 86/202 (42%), Gaps = 21/202 (10%)
Query: 463 ISTKDTRQARGRSWVMIEPSGAVQR---DQTVLEGGPCQLSCNVKASESPSIFWVLPDGS 519
I+ A G++ ++++ ++ D + EG L C + S P+I W DG
Sbjct: 2827 IAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWD-KDGQ 2885
Query: 520 ILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ-VRDEMDRMVYRVLVQSP--S 576
P+ + KF+I SG L +K++E D+G Y C A+ R V+ ++ P +
Sbjct: 2886 ----PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFT 2941
Query: 577 TQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTL 636
T P ++ G+ + L C A P + W + +R + ++ TL
Sbjct: 2942 TLPGDRSL-----RLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQD-----GGSTL 2991
Query: 637 SIPKVQVSDSGYYRCVAVNQQG 658
V DSG Y C A N+ G
Sbjct: 2992 QRAAVSREDSGTYVCWAENRVG 3013
Score = 60.5 bits (145), Expect = 2e-08
Identities = 46/175 (26%), Positives = 72/175 (41%), Gaps = 14/175 (8%)
Query: 496 PCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSDSGLYQ 554
P L C P+I W + + P +L+ GW L++ + DSGLY
Sbjct: 1178 PLTLLCEAMGIPPPAIRWFRGEEPV------SPGEDTYLLAGGWMLKMTQTQEQDSGLYS 1231
Query: 555 CIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILP 614
C+A R + V V P + E I G++ L CN P+ L+W
Sbjct: 1232 CLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 1291
Query: 615 NRRIINDLANTSHVYMLPNGT-LSIPKVQVSDSGYYRCVAVNQQG--ADHFTVGI 666
R LA ++ P+G L + + +S +G+Y C+A N G HF + +
Sbjct: 1292 GR----PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 1342
Score = 58.9 bits (141), Expect = 7e-08
Identities = 52/185 (28%), Positives = 80/185 (43%), Gaps = 19/185 (10%)
Query: 484 AVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIK 543
+ + TV P L C A SP+I W + DG AP + + + + L+I
Sbjct: 1355 SADEEVTVTVNNPISLICEALAFPSPNITW-MKDG----APFEASRNIQLLPGTHGLQIL 1409
Query: 544 SMEPSDSGLYQCIAQVRDEMDRMV--YRVLVQSPSTQPAEKDTVTIGKNP-----GESVT 596
+ + D+G Y C+ V +E+ V Y V V P + + +G ++T
Sbjct: 1410 NAQKEDAGQYTCV--VTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLT 1467
Query: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTL-SIPKVQVSDSGYYRCVAVN 655
L C + A+P + W + + +S + +L G L I QVSDSG Y CVA N
Sbjct: 1468 LECESWAVPPPTIRWYKDGQPV----TPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523
Query: 656 QQGAD 660
G D
Sbjct: 1524 VAGED 1528
Score = 58.5 bits (140), Expect = 9e-08
Identities = 46/175 (26%), Positives = 72/175 (41%), Gaps = 13/175 (7%)
Query: 486 QRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSM 545
Q D TV P L+C+ +P++ W S A + S + + SG L I
Sbjct: 2672 QTDFTVTMMAPVVLTCHSTGIPAPTVSW-----SKAGAQLGARGSGYRVSPSGALEIGQA 2726
Query: 546 EPSDSGLYQCIAQVRDEM-DRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
P +G Y C A+ + + V+ + SP +P + + E V LPC A I
Sbjct: 2727 LPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAE---EEVLLPCEASGI 2783
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
P ++W + ++ +LP G L I D+G Y C+A N G+
Sbjct: 2784 PRPTITWQKEGLNVATGVSTQ----VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2834
Score = 57.8 bits (138), Expect = 2e-07
Identities = 62/233 (26%), Positives = 97/233 (41%), Gaps = 16/233 (6%)
Query: 439 IQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTV--LEGGP 496
+QL R QS+ V Y + S + + + R +V GA R V + G P
Sbjct: 367 LQLGRAQSSDAGV---YTCKASNAVGAAE-KATRLDVYVPPTIEGAGGRPYVVKAVAGRP 422
Query: 497 CQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCI 556
L C + SP++ W + ++ ++ S+L R++S + SGLY C+
Sbjct: 423 VALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVL-----RLESPGEASSGLYSCV 477
Query: 557 AQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNR 616
A + Y V VQ P + + G+ + LPC A P + W L N
Sbjct: 478 ASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW-LQNG 536
Query: 617 RIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
R +LA V + G TL I V++ SG + C A N+ G V ++V
Sbjct: 537 RPAEELAG---VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 586
Score = 57.0 bits (136), Expect = 3e-07
Identities = 47/189 (24%), Positives = 78/189 (41%), Gaps = 16/189 (8%)
Query: 481 PSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWL 540
P+ V +QT L L C +P + W + P+D +F IL G L
Sbjct: 2489 PAVNVSVNQTAL------LPCQADGVPAPLVSWRKD-----RVPLDPRSPRFEILPEGSL 2537
Query: 541 RIKSMEPSDSGLYQCIAQVRDEMDRMVYRV-LVQSPSTQPAEKDTVTIGKNPGESVTLPC 599
RI+ + D+G Y C+A DR + +++ P+ P+ + P LPC
Sbjct: 2538 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP---ALLPC 2594
Query: 600 NALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
A P+ + W +++ L ++ +LP+ L + DS + CV N+ G
Sbjct: 2595 EASGSPKPLVVWWKDGQKLDFRLQQGAY-RLLPSNALLLTAPGPQDSAQFECVVSNEVGE 2653
Query: 660 DHFTVGITV 668
H +TV
Sbjct: 2654 AHRLYQVTV 2662
Score = 56.6 bits (135), Expect = 3e-07
Identities = 44/162 (27%), Positives = 70/162 (43%), Gaps = 18/162 (11%)
Query: 508 SPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIA-QVRDEMDRM 566
SP W P G + + P L+I+ ++ D G+Y C A + E R
Sbjct: 638 SPGSLWGEPTGIPVAYSLPPP-----------LQIEKVDLRDEGIYTCAATNLAGESKRE 686
Query: 567 VYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTS 626
V ++ P+ +P + + SVTL C A +P +SW ++ + + + T
Sbjct: 687 VALKVLVPPNIEPGPVNKAVL---ENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTV 743
Query: 627 HVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
V L I + Q+SD+G YRCVA N G+ G+ V
Sbjct: 744 SV---DGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV 782
Score = 55.8 bits (133), Expect = 6e-07
Identities = 50/199 (25%), Positives = 78/199 (39%), Gaps = 10/199 (5%)
Query: 472 RGRSWVMIEPSGAVQRDQ--TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPD 529
+GR ++EP T+ P L C S P + W DG L +
Sbjct: 2563 QGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVW-WKDGQKLDFRLQQ-- 2619
Query: 530 SKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGK 589
+ +L S L + + P DS ++C+ +Y+V V P T ++ T+
Sbjct: 2620 GAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTM 2679
Query: 590 NPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYY 649
V L C++ IP +SW ++ A S + P+G L I + +G Y
Sbjct: 2680 MA--PVVLTCHSTGIPAPTVSWSKAGAQLG---ARGSGYRVSPSGALEIGQALPIHAGRY 2734
Query: 650 RCVAVNQQGADHFTVGITV 668
C A N G H V +TV
Sbjct: 2735 TCSARNSAGVAHKHVFLTV 2753
Score = 55.5 bits (132), Expect = 8e-07
Identities = 45/174 (25%), Positives = 65/174 (37%), Gaps = 19/174 (10%)
Query: 492 LEGGPCQLSCNVKASESPSIFW------VLPDGSILKAPMDDPDSKFSILSSGWLRIKSM 545
L G +L C +P + W VLP G L+ D LRI
Sbjct: 230 LAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV----------LRITGS 279
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP 605
D G YQC+A +++ V +P T +T + V L C A +P
Sbjct: 280 HVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP 339
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
+++W + +T VY L + + Q SD+G Y C A N GA
Sbjct: 340 TPNITWFKDGALLPT---STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA 390
Score = 55.1 bits (131), Expect = 1e-06
Identities = 37/174 (21%), Positives = 70/174 (40%), Gaps = 19/174 (10%)
Query: 486 QRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSM 545
Q D V+ G +L C + P + W+ +L ++ S L+++++
Sbjct: 2222 QNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPS---------LQLEAV 2272
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP 605
DSG Y C+A R +++ V P + PG + L C+A P
Sbjct: 2273 GAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTP 2332
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
+ +++W + + L N + + ++V D+G Y C+A + GA
Sbjct: 2333 QPNITWHKDGQALTR----------LENNSRATRVLRVRDAGLYTCLAESPAGA 2376
Score = 54.7 bits (130), Expect = 1e-06
Identities = 49/184 (26%), Positives = 71/184 (38%), Gaps = 13/184 (7%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
++ VLE L C P + W P+ + LRI+ +
Sbjct: 703 NKAVLENASVTLECLASGVPPPDVSWFKGH-----QPVSSWMGVTVSVDGRVLRIEQAQL 757
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLVQSPS--TQPAEKDTVTIGKNPGESVTLPCNALAIP 605
SD+G Y+C+A + Y + V P T P + P V L CNA P
Sbjct: 758 SDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP---VRLTCNATGAP 814
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
L W+ + A T + + P G L++ + SDSG Y CVAV+ G D V
Sbjct: 815 SPTLMWLKDGNPV--SPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV 872
Query: 665 GITV 668
+ V
Sbjct: 873 VLQV 876
Score = 54.7 bits (130), Expect = 1e-06
Identities = 50/190 (26%), Positives = 73/190 (38%), Gaps = 26/190 (13%)
Query: 534 ILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGE 593
+L G LRI P D+G Y CIA+ R++VQ P E + G
Sbjct: 2805 VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV--IENGLPDLSTTEGS 2862
Query: 594 SVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
LPC A PE +++W + + + + P+G L + ++ D+G Y C A
Sbjct: 2863 HAFLPCKARGSPEPNITWDKDGQPVSGAEGKFT---IQPSGELLVKNLEGQDAGTYTCTA 2919
Query: 654 VNQQGADHFTVGIT--VTKKGSGLPSKRGRRPGAKALSR-------------------VR 692
N G V +T V + LP R R G + R V
Sbjct: 2920 ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT 2979
Query: 693 EDIVEDEGGS 702
E + E +GGS
Sbjct: 2980 EGVSEQDGGS 2989
Score = 51.2 bits (121), Expect = 1e-05
Identities = 47/176 (26%), Positives = 73/176 (41%), Gaps = 21/176 (11%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
VL+G L CNV P + W DG P+ D+ L++ S +
Sbjct: 1266 VLDGQTAHLMCNVTGHPQPKLTW-FKDG----RPLARGDAHHISPDGVLLQVLQANLSSA 1320
Query: 551 GLYQCIA--QVRDEMDRMVYRVL----VQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
G Y CIA V ++ VL + + A+++ NP ++L C ALA
Sbjct: 1321 GHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP---ISLICEALAF 1377
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGT--LSIPKVQVSDSGYYRCVAVNQQG 658
P +++W+ + ++ +LP GT L I Q D+G Y CV N+ G
Sbjct: 1378 PSPNITWMKDGA----PFEASRNIQLLP-GTHGLQILNAQKEDAGQYTCVVTNELG 1428
Score = 50.8 bits (120), Expect = 2e-05
Identities = 45/175 (25%), Positives = 75/175 (42%), Gaps = 20/175 (11%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
D+++ G L C + S +P I W + D + + + L+ ++
Sbjct: 2946 DRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQD-------GGSTLQRAAVSR 2998
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
DSG Y C A+ R + V V V+ E + + + G S+ L C P
Sbjct: 2999 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLV-EPVGGSIQLDCVVRGDPVP 3057
Query: 608 HLSWI---LPNRRIINDLANTSHV-YMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ WI LP R SH+ + L NG+L+I + + D+G Y+C+A N+ G
Sbjct: 3058 DIHWIKDGLPLRG--------SHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMG 3104
Score = 50.1 bits (118), Expect = 3e-05
Identities = 54/185 (29%), Positives = 75/185 (40%), Gaps = 36/185 (19%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG-WLRIKSMEPSDSGLYQCIA 557
L C A P+I W DG + P S+ +L G L+I+ + SDSG Y C+A
Sbjct: 1468 LECESWAVPPPTIRWY-KDGQPVT-----PSSRLQVLGEGRLLQIQPTQVSDSGRYLCVA 1521
Query: 558 QVRDEMDRMVYRVLVQSP----------------STQPAEKDTVT-----IGKNPGESVT 596
D + VL+Q P S + + VT + NP
Sbjct: 1522 TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNP---AY 1578
Query: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVN 655
L C+ AIP L+W R L+ V +L G L IP V+ ++G Y C A N
Sbjct: 1579 LYCDTNAIPPPDLTWY----REDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASN 1634
Query: 656 QQGAD 660
+ G D
Sbjct: 1635 EVGED 1639
Score = 49.7 bits (117), Expect = 4e-05
Identities = 56/204 (27%), Positives = 84/204 (41%), Gaps = 23/204 (11%)
Query: 479 IEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG 538
IE SG + ++ G P +L C+ + + P+I W DG L L +
Sbjct: 2305 IEDSGQ-PTELSLTPGAPMELLCDAQGTPQPNITWH-KDGQALTR-----------LENN 2351
Query: 539 WLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEK-DTVTIGKNPGESVTL 597
+ + D+GLY C+A+ +RV VQ+P + +G PG+ V L
Sbjct: 2352 SRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-L 2410
Query: 598 PCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGT-LSIPKVQVSDSGYYRCVAVNQ 656
C+ A P ++W R L +H G L + + +DSG Y C A N
Sbjct: 2411 ECSVEAEPAPKITW----HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 2466
Query: 657 QGADH--FTVGI-TVTKKGSGLPS 677
G+ F V I TV SG P+
Sbjct: 2467 AGSTSVAFRVEIHTVPTIRSGPPA 2490
Score = 48.5 bits (114), Expect = 9e-05
Identities = 44/183 (24%), Positives = 73/183 (39%), Gaps = 14/183 (7%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
T + L C+V A +P + W ++ + F + + L++ SD
Sbjct: 1757 TAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG-----EEVFLLPGTHTLQLGRARLSD 1811
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQSP----STQPAEKDTVTIGKNPGESVTLPCNALAIP 605
SG+Y C A D+ + ++ V P +D V + G+ L C A+P
Sbjct: 1812 SGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLV--RVGDKAVLSCETDALP 1869
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVG 665
E ++W + ++ LA + + L I + QVSD G Y C N G T
Sbjct: 1870 EPTVTWYKDGQPLV--LAQRTQA-LRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT 1926
Query: 666 ITV 668
+TV
Sbjct: 1927 LTV 1929
Score = 42.4 bits (98), Expect = 0.007
Identities = 27/115 (23%), Positives = 47/115 (40%), Gaps = 10/115 (8%)
Query: 501 CNVKASESPSIFWVLPDGSILKAPMDDP---DSKFSILSSGWLRIKSMEPSDSGLYQCIA 557
C + P + W K P +P ++L G L + S+ P+DSG Y+C A
Sbjct: 24 CGTHGTPKPQVTW-------RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQA 76
Query: 558 QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWI 612
+++V P + + + G+S+TL C+A P + W+
Sbjct: 77 TNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 131
Score = 38.9 bits (89), Expect = 0.073
Identities = 45/173 (26%), Positives = 65/173 (37%), Gaps = 13/173 (7%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
TV EG P LSC + P I W DG L P + + L + + +
Sbjct: 982 TVREGHPTSLSCECRGVPFPKISW-RKDGQPL--PGEGAGLQHVSAVGRLLYLGQAQLAQ 1038
Query: 550 SGLY--QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
G Y +C V + + V V P E T G + TL CNA P
Sbjct: 1039 EGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA-TLECNATGKPPP 1097
Query: 608 HLSWILPNRRIINDLANTSHVYMLPN--GTLSIPKVQVSDSGYYRCVAVNQQG 658
++W + + +L L N +L + + Q + +G Y CVA N G
Sbjct: 1098 TVTWERDGQPVGAELG-----LQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 1145
Score = 36.6 bits (83), Expect = 0.36
Identities = 22/71 (30%), Positives = 33/71 (46%), Gaps = 6/71 (8%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
+D TV G L C +P+I W L G L+A + L G L ++++E
Sbjct: 3125 QDMTVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRA-----SRRLRTLPDGSLWLENVE 3178
Query: 547 PSDSGLYQCIA 557
D+G Y C+A
Sbjct: 3179 TGDAGTYDCVA 3189
Score = 34.3 bits (77), Expect = 1.8
Identities = 34/160 (21%), Positives = 58/160 (36%), Gaps = 7/160 (4%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ 558
L C A P + W DG P++ L++ + D+G Y C A
Sbjct: 899 LECQSHAMPPPVLSW-WKDGR----PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 953
Query: 559 VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRI 618
+ Y + V P +++ T+ G +L C +P +SW + +
Sbjct: 954 NQAGRSEKHYNLNVWVAPVFPL-RESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL 1012
Query: 619 INDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ A HV + L + + Q++ G Y C N G
Sbjct: 1013 PGEGAGLQHVSAV-GRLLYLGQAQLAQEGTYTCECSNVVG 1051
Score = 32.7 bits (73), Expect = 5.2
Identities = 41/184 (22%), Positives = 68/184 (36%), Gaps = 19/184 (10%)
Query: 859 SSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITSTEGDLKGTAAPTLI---- 914
+S +G + H ++++ P V EE+V++++ S + G PT+
Sbjct: 1632 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1691
Query: 915 SEPYEPSPTLHTLD--TVYEKPTHEETATEGWSAADVGSSPEPTSSEYEPPLDAVSLAES 972
P+ PSP L L+ V + T E AD S ++ +L
Sbjct: 1692 GLPFSPSPRLQVLEDGQVLQVSTAE--------VADAASYMCVAENQAGSAEKLFTLRVQ 1743
Query: 973 EPMQYFDPDLETKSQPDEDKMKEDTFAHLTPTPTI-WVNDSSTSQLFEDSTIGEPGVPGQ 1031
P + DLE + + H P P + W DS L E+ + +PG
Sbjct: 1744 VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFL----LPGT 1799
Query: 1032 SHLQ 1035
LQ
Sbjct: 1800 HTLQ 1803
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 307 bits (786), Expect = 1e-82
Identities = 269/973 (27%), Positives = 408/973 (41%), Gaps = 84/973 (8%)
Query: 1860 PQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQ 1919
P +S+T C+A G P+P +TW K Q L+N + R ++
Sbjct: 3502 PTELSLTPGAPMELLCDAQGTPQPNITWHKDG-----------QALTRLENNSRATRVLR 3550
Query: 1920 VQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGD-TIAMECLAKGTP 1978
V+D G Y C A + G + V P I+ V L + +EC + P
Sbjct: 3551 VRDAGLYTCLAESPAGAIEKSFRVRVQAP-PNIVGPRGPRFVVGLAPGQLVLECSVEAEP 3609
Query: 1979 APQISWIFPDRRVWQ----TVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGAD 2034
AP+I+W D V Q T P GR L ++ S +D G Y C A NAAG+
Sbjct: 3610 APKITW-HRDGIVLQEDAHTQFPERGRF-------LQLQALSTADSGDYSCTARNAAGST 3661
Query: 2035 SLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQF 2094
S+A R+ + +P + N+S+ + + C A P P V W D + P
Sbjct: 3662 SVAFRVEIHTVPTIRSGPPAVNVSV--NQTALLPCQADGVPAPLVSW-RKDRVPLDPRS- 3717
Query: 2095 LHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPR 2154
+ P G+L I+ + +D+G Y C+A+N GS R+ L V A A SP
Sbjct: 3718 --PRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIA----PSPS 3771
Query: 2155 RTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDK 2214
+ L C ASG P P ++W +++ L ++ + L++ + +
Sbjct: 3772 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ--GAYRLLPSNALLLTAPGPQ 3829
Query: 2215 DAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPE 2274
D+ + CV N+VG+ + + +V V + P + ++ D V + + C +TG+P P
Sbjct: 3830 DSAQFECVVSNEVGEAHRLYQVTVHVPPTIAD--DQTDFTVTMMAPVVLTCHSTGIPAPT 3887
Query: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
+SWS L G R Y V +G L + G YTC A N G
Sbjct: 3888 VSWSKAGAQL----------GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 3937
Query: 2335 MRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEK 2394
V + V +P V+ + V + CEA G P P +TW V S
Sbjct: 3938 KHVFLTVQASPVV--KPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST- 3994
Query: 2395 YQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVRE 2454
Q+ G L I A D+GNY C+ +NSAG + V V P NG P+ TT
Sbjct: 3995 -QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTE-- 4051
Query: 2455 IAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSV 2514
GS + CKA G P P + W V A + T+ +G L +++L D+
Sbjct: 4052 ----GSHAFLPCKARGSPEPNITWDKDGQPVSGAE---GKFTIQPSGELLVKNLEGQDAG 4104
Query: 2515 QLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSL 2574
C A N G AR + LT+L P+F ++ + G + L C+A G+PTP +
Sbjct: 4105 TYTCTAENAVGRARRRVHLTILV---LPVFTTLPGDRSLRL-GDRLWLRCAARGSPTPRI 4160
Query: 2575 VWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVG 2634
W + N + G Q L + +S D+G Y C A N G T+ + + V
Sbjct: 4161 GWTV-NDRPVTEGVSEQ----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 4215
Query: 2635 LKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNG 2694
P + + + G +++L C G W + +G+ L G + L NG
Sbjct: 4216 EAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHW-IKDGLPLRGSHLRHQ---LQNG 4271
Query: 2695 TLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLN 2754
+LT+ D G Y C E E G + + ++V+ P EP + R G+ V L
Sbjct: 4272 SLTIHRTERDDAGRYQCLAENEMGVA-KKVVILVLQSAPVFQVEPQDMT-VRSGDDVALR 4329
Query: 2755 CMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKN 2814
C A G P I W L+AG R P GSL +++ DAG Y C+A N
Sbjct: 4330 CQATGEPTPTIEW-------LQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHN 4382
Query: 2815 ILGSDSKTTYIHV 2827
+LGS + ++ V
Sbjct: 4383 LLGSATARAFLVV 4395
Score = 295 bits (756), Expect = 3e-79
Identities = 287/986 (29%), Positives = 422/986 (42%), Gaps = 113/986 (11%)
Query: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG-TLVIRKVQ 1919
+ V+V A + C A G P P ++W + G +P+ R+Q VL++G L + +
Sbjct: 2853 EEVTVNASSTVSLQCPALGNPVPTISW--LQNGLPFSPSPRLQ---VLEDGQVLQVSTAE 2907
Query: 1920 VQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPA 1979
V D YMC A N G + L V V P+I + VT L ++++ C P
Sbjct: 2908 VADAASYMCVAENQAGSAEKLFTLRVQVP-PRIAGLDLEQVTAILNSSVSLPCDVHAHPN 2966
Query: 1980 PQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIR 2039
P+++W + D Q +S E L TL + A SD G+Y C A NAAG D ++
Sbjct: 2967 PEVTW-YKDS---QALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 3022
Query: 2040 LHVAALPPVIHQEKL---ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI---RPSQ 2093
L V +PP Q + + + G + C A P P+V W DG + + +Q
Sbjct: 3023 LSVL-VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK-DGQPLVLAQRTQ 3080
Query: 2094 FLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSP 2153
L G L I+ D G Y C +N+ G A RT L VQ T +P
Sbjct: 3081 ALRGGQ------RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPP-----TFENP 3129
Query: 2154 RRTDVRY--GGTLKLDCSASGDPWPRILW---RLPSKRMIDALFSFDSRIKVFANGTLVV 2208
+ V G L L C SG P P + W R+P + A+ SR G L +
Sbjct: 3130 KTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES--SAVHGVVSR-----GGRLQL 3182
Query: 2209 KSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVAT 2268
+ AG Y CVA N + V V++ P +H V G ++++DC A
Sbjct: 3183 SRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEAD 3242
Query: 2269 GLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAEN 2328
G P P+++W L DGS + D G + Y+ + G+L + + G YTC A N
Sbjct: 3243 GQPPPDVAW-LKDGSPL-----GQDMGPHLRFYL--DGGSLVLKGLRASDAGAYTCVAHN 3294
Query: 2329 QVGKDEMRVRVKVVTAPATIR---NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTN 2385
G+D R+ V P TI+ + + V P G++VT+ C +G P V+WL
Sbjct: 3295 PAGED-ARLHTVNVLVPPTIKQGADGSGTLVSRP-GELVTMVCPVRGSPPIHVSWLK-DG 3351
Query: 2386 KVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKIN-- 2443
+P S TL I K Q +D+G +TC+ + AG + + V V PP +
Sbjct: 3352 LPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV-PPVLEPV 3410
Query: 2444 GNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSL 2503
N + VR GS + C+A G+P P V W +G L + ++ SL
Sbjct: 3411 EFQNDVVVVR-----GSLVELPCEARGVPLPLVSW-MKDGEPLLSQ------SLEQGPSL 3458
Query: 2504 DIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLN 2563
+ ++ DS C+A +E GEAR QLTV+EP P +T G + L
Sbjct: 3459 QLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLT--PGAPMELL 3516
Query: 2564 CSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYH--KADGMLHISGLSSVDAGAYRCVARNA 2621
C A GTP P++ W + GQ L R + +A +L + DAG Y C+A +
Sbjct: 3517 CDAQGTPQPNITW-------HKDGQALTRLENNSRATRVLRVR-----DAGLYTCLAESP 3564
Query: 2622 AGHTERLVSLKVGLKPE--ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSW-----TLP 2674
AG E+ ++V P + +V + G+ L L C+ + +W L
Sbjct: 3565 AGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQ 3623
Query: 2675 NGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPR 2734
H + P+ GR L ++ S D G Y C G + + V I P
Sbjct: 3624 EDAHTQFPER-GRF-------LQLQALSTADSGDYSCTARNAAGSTSVAFRV-EIHTVPT 3674
Query: 2735 ITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRF-LHPQG 2793
I S P P + T L C A G+P ++W K V RF + P+G
Sbjct: 3675 IRSGP-PAVNVSVNQTALLPCQADGVPAPLVSWR-------KDRVPLDPRSPRFEILPEG 3726
Query: 2794 SLTIQHATQRDAGFYKCMAKNILGSD 2819
SL IQ +DAG Y C+A N GSD
Sbjct: 3727 SLRIQPVLAQDAGHYLCLASNSAGSD 3752
Score = 286 bits (732), Expect = 2e-76
Identities = 266/992 (26%), Positives = 405/992 (40%), Gaps = 126/992 (12%)
Query: 1903 QRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTV 1962
+ F+ N + I + + G Y CTA + G R + VT PQ++ + +VTV
Sbjct: 471 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA--PNVTV 528
Query: 1963 YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGV 2022
G+T + C G ++W+ R W+ + GR+ + +L I +D G
Sbjct: 529 SPGETAVLSCRVLGEAPYNLTWV----RDWRVLPASTGRVAQLADLSLEISGIIPTDGGR 584
Query: 2023 YKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWV 2082
Y+CVASNA G ++ L V P V ++ S G+ + + C+A P P + W
Sbjct: 585 YQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISW- 641
Query: 2083 LGDGTQIRPSQFLH--GNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ 2140
R SQ L + V GTL I+ +AP+D+G Y C A N VG+ + TV L
Sbjct: 642 ------SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 695
Query: 2141 RAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV 2200
+ + + V G L C ASG P PR++W MI A S
Sbjct: 696 DPPSVSAVNAV----VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS---- 747
Query: 2201 FANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGD 2260
G L + + ++DAG Y C A N++GD +++ V P E D V G
Sbjct: 748 ---GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTE--LPRDVTVELGRS 802
Query: 2261 LKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEG 2320
+ C ATG P P ++W DG + + GR R ++G L+F V ++
Sbjct: 803 ALLACRATGRPPPTVTWRRGDGQPLGLRL----GAGRGSRSRQPDSGVLFFESVAPEDQA 858
Query: 2321 DYTCFAENQVGKDEMRVRVKVV-TAPATIRNKTYLAVQVPYGDVVTVAC-EAKGEPMPKV 2378
Y C A N GK + R+ V AP I + V+V G V++ C G P+P+
Sbjct: 859 PYVCEARNVFGKVQAEARLIVTGHAPPQIASSA-PTVRVLEGQPVSLPCIVLAGRPLPER 917
Query: 2379 TWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQ 2438
WL + P S ++ I DG+L + +A + +G Y+C+ N+AG + V + V V
Sbjct: 918 HWLKDGRPLPPGS--RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV- 974
Query: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLW---------------AFPEG 2483
PP+I+ T I G + C A G+P P + W EG
Sbjct: 975 PPRIHP-----TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG 1029
Query: 2484 VVLPA-----------------------------------PYYGNRITVHGNGSLDIRSL 2508
+L A Y + +GSL + +
Sbjct: 1030 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQV 1089
Query: 2509 RKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAG 2568
+ DS C A N G A L V P + P + + G + LNC A G
Sbjct: 1090 QVGDSGHYECTASNPAGSASHRYVLGVQVPPQV----QPGPRVLKVLVGEALDLNCVAEG 1145
Query: 2569 TPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERL 2628
P P L W +G LQ G +H + + + DAG YRC A N+AG
Sbjct: 1146 NPEPQLSW-SKDGVVLQG--------RGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWE 1196
Query: 2629 VSLKVGLKPE-ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTL-PNGMHLEGPQTLG 2686
V L+V P + L+ + GE LPC G + + +W P+ L G
Sbjct: 1197 VELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQP--- 1253
Query: 2687 RVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPV-IYT 2745
V++L+ G+L + S D G Y C+ E G S + +V+ PP I + +
Sbjct: 1254 GVAVLEEGSLFLASVSPADSGDYECQATNEVG-STSRRAKLVVYVPPSIREDGRKANVSG 1312
Query: 2746 RPGNTVKLNCMAMGIPKADITWELPDKSHLKAGV----------QARLYGNRFLHPQGSL 2795
G ++ L C A G P +I W L D + + ++ G+R L SL
Sbjct: 1313 MAGQSLTLECDANGFPVPEIVW-LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSL 1371
Query: 2796 TIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ D+G Y C A+N G+ + ++ V
Sbjct: 1372 HFPRIQEGDSGLYSCRAENQAGTAQRDFHLLV 1403
Score = 283 bits (724), Expect = 2e-75
Identities = 266/960 (27%), Positives = 399/960 (41%), Gaps = 91/960 (9%)
Query: 1874 PCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG-TLVIRKVQVQDRGQYMCTASN 1932
PCEA G P P V+W K L + L+ G +L + V D G Y C A +
Sbjct: 3427 PCEARGVPLPLVSWMKDGEPLLS---------QSLEQGPSLQLEAVGAGDSGTYSCVAVS 3477
Query: 1933 LHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAME--CLAKGTPAPQISWIFPDRR 1990
G R L TV +P + Q + L ME C A+GTP P I+W +
Sbjct: 3478 EAGEARRHFQL--TVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQA 3535
Query: 1991 VWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIH 2050
+T EN + + + D G+Y C+A + AGA + R+ V A P ++
Sbjct: 3536 -----------LTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVG 3584
Query: 2051 QEKLENI-SLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRP---SQFLHGNLFVFPNGT 2106
+ L PG + + C+ +A P P + W DG ++ +QF F
Sbjct: 3585 PRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHR-DGIVLQEDAHTQFPERGRF------ 3636
Query: 2107 LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKL 2166
L ++ L+ DSG Y C A N GS ++ + + P +V T L
Sbjct: 3637 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPT----IRSGPPAVNVSVNQTALL 3692
Query: 2167 DCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNK 2226
C A G P P + WR L R ++ G+L ++ V +DAG YLC+A N
Sbjct: 3693 PCQADGVPAPLVSWRKDRV----PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 3748
Query: 2227 VGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVN 2286
G D + V+ PA I N + L + C A+G P P + W DG ++
Sbjct: 3749 AGSDRQGRDLRVLEPPA-IAPSPSNLTLTAHTPAL-LPCEASGSPKPLVVW-WKDGQKLD 3805
Query: 2287 SFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPA 2346
+Q Y + + L G ++ + C N+VG+ +V V P
Sbjct: 3806 FRLQQG-------AYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPT 3858
Query: 2347 TIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQ 2406
++T V + V+T C + G P P V+W S + Y++ G L I
Sbjct: 3859 IADDQTDFTVTMMAPVVLT--CHSTGIPAPTVSW-SKAGAQLGARGSGYRVSPSGALEIG 3915
Query: 2407 KAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466
+A +G YTC RNSAG K V++ V P + P+ + V E L+ C
Sbjct: 3916 QALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV-VKPLPSVVRAVAE-----EEVLLPC 3969
Query: 2467 KAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGE 2526
+A GIP P + W EG+ + G V G L I D+ +C+A+N G
Sbjct: 3970 EASGIPRPTITWQ-KEGLNVAT---GVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 4025
Query: 2527 ARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQS 2586
A +L V P P+ + + + T H L C A G+P P++ W +G +
Sbjct: 4026 AMGKTRLVVQVP---PVIENGLPDLSTTEGSHAF-LPCKARGSPEPNITWD-KDGQPVSG 4080
Query: 2587 GQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNL 2646
+ +F + G L + L DAG Y C A NA G R V L + + P +
Sbjct: 4081 AEG--KFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 4138
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREA-SVFD 2705
S+ G+ L L C G+ R WT+ + EG VS D G+ R A S D
Sbjct: 4139 -SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG------VSEQDGGSTLQRAAVSRED 4191
Query: 2706 RGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADI 2765
GTYVC E G + ++ + + P + E + G +++L+C+ G P DI
Sbjct: 4192 SGTYVCWAENRVGRT-QAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDI 4250
Query: 2766 TWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYI 2825
W +K G+ R R GSLTI + DAG Y+C+A+N +G K +
Sbjct: 4251 HW-------IKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVIL 4303
Score = 282 bits (722), Expect = 3e-75
Identities = 257/962 (26%), Positives = 402/962 (41%), Gaps = 91/962 (9%)
Query: 1875 CEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH 1934
C G P V+W K ++ T + TL I KVQ+ D G + C A++
Sbjct: 3335 CPVRGSPPIHVSWLKDGLPLPLSQRTLLHG----SGHTLRISKVQLADAGIFTCVAASPA 3390
Query: 1935 GL-DRMVVLLSVTVQQPQIL--ASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV 1991
G+ DR L VQ P +L DV V G + + C A+G P P +SW+
Sbjct: 3391 GVADRNFTL---QVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWM------ 3441
Query: 1992 WQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQ 2051
+ P+ + +L + +L ++ D G Y CVA + AG +L V P +
Sbjct: 3442 -KDGEPLLSQ-SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 3499
Query: 2052 EKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRN 2111
+ +SL PG + + C A+ P P++ W DG + + N + R
Sbjct: 3500 GQPTELSLTPGAPMELLCDAQGTPQPNITW-HKDGQALTRLE----------NNSRATRV 3548
Query: 2112 LAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITG-TSPRRTDVRYGGTLKLDCSA 2170
L +D+G Y C+A + G+ ++ ++ VQ A I G PR G L L+CS
Sbjct: 3549 LRVRDAGLYTCLAESPAGAIEKSFRVRVQ---APPNIVGPRGPRFVVGLAPGQLVLECSV 3605
Query: 2171 SGDPWPRILW-RLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD 2229
+P P+I W R DA F R + L +++++ D+GDY C ARN G
Sbjct: 3606 EAEPAPKITWHRDGIVLQEDAHTQFPERGRF-----LQLQALSTADSGDYSCTARNAAGS 3660
Query: 2230 DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFM 2289
V +V++ P V + C A G+P P +SW L
Sbjct: 3661 TSVAFRVEIHTVPT--IRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPL----- 3713
Query: 2290 QSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIR 2349
R+ R+ + G+L V ++ G Y C A N G D ++V+ PA
Sbjct: 3714 -----DPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAP 3768
Query: 2350 NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKV-IPTSSEKYQIYQDGTLLIQKA 2408
+ + L + + CEA G P P V W K+ Y++ LL+
Sbjct: 3769 SPSNLTLTA--HTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAP 3826
Query: 2409 QRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKA 2468
DS + C+V N GE + + V+V PP I + T ++ C +
Sbjct: 3827 GPQDSAQFECVVSNEVGEAHRLYQVTVHV-PPTIADDQTDFTVTMMAPV-----VLTCHS 3880
Query: 2469 EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEAR 2528
GIP P V W+ G L A G R++ +G+L+I + + C ARN G A
Sbjct: 3881 TGIPAPTVSWS-KAGAQLGARGSGYRVS--PSGALEIGQALPIHAGRYTCSARNSAGVAH 3937
Query: 2529 LILQLTV-LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSG 2587
+ LTV P+ K P+ + A+A + L C A+G P P++ W G ++ +G
Sbjct: 3938 KHVFLTVQASPVVK-----PLPSVVRAVAEEEVLLPCEASGIPRPTITW-QKEGLNVATG 3991
Query: 2588 QQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLV 2647
Q G L I+ S DAG Y C+A+N+AG L V + P +L
Sbjct: 3992 VSTQVL---PGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDL- 4047
Query: 2648 SIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRG 2707
S G LPC G+ + +W +G + G + G+ ++ +G L V+ D G
Sbjct: 4048 STTEGSHAFLPCKARGSPEPNITWD-KDGQPVSGAE--GKFTIQPSGELLVKNLEGQDAG 4104
Query: 2708 TYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITW 2767
TY C E G + + + ++ P T + R G+ + L C A G P I W
Sbjct: 4105 TYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL--RLGDRLWLRCAARGSPTPRIGW 4162
Query: 2768 ELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHA--TQRDAGFYKCMAKNILGSDSKTTYI 2825
+ D+ + GV + G T+Q A ++ D+G Y C A+N +G +++
Sbjct: 4163 TVNDRP-VTEGVSEQ---------DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 4212
Query: 2826 HV 2827
HV
Sbjct: 4213 HV 4214
Score = 276 bits (706), Expect = 2e-73
Identities = 267/1049 (25%), Positives = 405/1049 (38%), Gaps = 139/1049 (13%)
Query: 1848 SLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTG--ALMTPNTRIQRF 1905
++G PQ LT+ P+ V+V + C ATG+P P VTW + L R R
Sbjct: 781 AVGHAPQ-LTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRS 839
Query: 1906 EVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLG 1965
+G L V +D+ Y+C A N+ G + L VT P +AS V V G
Sbjct: 840 RQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEG 899
Query: 1966 DTIAMECLA-KGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYK 2024
+++ C+ G P P+ W+ R + P R ++ + +L + A G Y
Sbjct: 900 QPVSLPCIVLAGRPLPERHWLKDGRPL-----PPGSRHSIRADGSLHLDRALQEHAGRYS 954
Query: 2025 CVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRW--- 2081
CVA+N AG+ + L V +PP IH +I+ G+ + C A P P++ W
Sbjct: 955 CVATNTAGSQHRDVEL-VVQVPPRIHPTATHHIT-NEGVPASLPCVASGVPAPTITWTKE 1012
Query: 2082 ------------VLGDGT----------------------------------QIRPSQFL 2095
V +GT ++ S+++
Sbjct: 1013 TNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYV 1072
Query: 2096 HGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRR 2155
+ P+G+L + + DSG YEC A+N GSA L VQ PR
Sbjct: 1073 WEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQ----VQPGPRV 1128
Query: 2156 TDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKD 2215
V G L L+C A G+P P++ W + G++ ++ D
Sbjct: 1129 LKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGR----------GPQGSVHFAAIRTSD 1178
Query: 2216 AGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEI 2275
AG Y C A N G D +++ V+ P + + G + + C A G P P++
Sbjct: 1179 AGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQV 1238
Query: 2276 SWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEM 2335
+W S+ G+ V G+L+ V + GDY C A N+VG
Sbjct: 1239 TW--------RKGPSSEPLHGQPG-VAVLEEGSLFLASVSPADSGDYECQATNEVGSTSR 1289
Query: 2336 RVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKV-IPTSSEK 2394
R ++ V P+ + V G +T+ C+A G P+P++ WL V +P
Sbjct: 1290 RAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAG 1349
Query: 2395 Y------------QIYQDG-TLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPK 2441
Y ++ +G +L + Q DSG Y+C N AG ++ + V + PP
Sbjct: 1350 YGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLV-LTPPS 1408
Query: 2442 INGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNG 2501
+ G + G+ + C G+PTP+V W VLP G + V +G
Sbjct: 1409 VLGAG---AAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG---GPHLQVQEDG 1462
Query: 2502 S-LDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTI 2560
L I D + C+A + G+ QL V P I+ + ++ M H +
Sbjct: 1463 QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP--PTIWGSNETGEVAVMEDHLV 1520
Query: 2561 SLNCSAAGTPTPSLVW-----VLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYR 2615
L C A G PTP++ W +LP T + Y + L + S DAG Y
Sbjct: 1521 QLLCEARGVPTPNITWFKDGALLPTSTKV--------VYTRGGRQLQLGRAQSSDAGVYT 1572
Query: 2616 CVARNAAGHTERLVSLKVGLKP--EANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTL 2673
C A NA G E+ L V + P E +V + G + L C G SW
Sbjct: 1573 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW-- 1630
Query: 2674 PNGMHLEG-PQTLGRVSLL--DNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIA 2730
H EG P S L D L + G Y C + G +V V V
Sbjct: 1631 ----HHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV 1686
Query: 2731 YPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITW-ELPDKSHLKAGVQARLYGNRFL 2789
P + +E + T G ++L C A G P I W + + AGVQ G
Sbjct: 1687 PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT--- 1743
Query: 2790 HPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
+L I H +G + C A N G+
Sbjct: 1744 ----TLHIDHVELDHSGLFACQATNEAGT 1768
Score = 272 bits (695), Expect = 4e-72
Identities = 293/1113 (26%), Positives = 469/1113 (42%), Gaps = 128/1113 (11%)
Query: 1762 RKVIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITS 1821
R + PGS + I + + HLD ++ T + + +++ +V I T+
Sbjct: 924 RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH-PTA 982
Query: 1822 SVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQ----------TVSVTAETDT 1871
+ + +S A G PA E + ++ P +A+
Sbjct: 983 THHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAG 1042
Query: 1872 VFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTAS 1931
+ C AT ++S L + + +L +G+L + +VQV D G Y CTAS
Sbjct: 1043 AYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTAS 1102
Query: 1932 NLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV 1991
N G +L V V PQ+ + + V +G+ + + C+A+G P PQ+SW D V
Sbjct: 1103 NPAGSASHRYVLGVQV-PPQVQPGP-RVLKVLVGEALDLNCVAEGNPEPQLSW-SKDGVV 1159
Query: 1992 WQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQ 2051
Q P +G + RT SD G Y+C ASN+AG D+ + L V P
Sbjct: 1160 LQGRGP-QGSVHFAAIRT--------SDAGRYRCEASNSAGVDAWEVELRVLEPPHWGAD 1210
Query: 2052 EKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHG--NLFVFPNGTLYI 2109
E + G + + C A+ P P V W G S+ LHG + V G+L++
Sbjct: 1211 ETSGLLERVAGENASLPCPARGTPKPQVTWRKGPS-----SEPLHGQPGVAVLEEGSLFL 1265
Query: 2110 RNLAPKDSGRYECVAANLVGSARRTVQL------NVQRAAANARITGTSPRRTDVRYGGT 2163
+++P DSG YEC A N VGS R +L +++ A ++G + G +
Sbjct: 1266 ASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMA--------GQS 1317
Query: 2164 LKLDCSASGDPWPRILWRLPSKRMID-----ALFSFD------SRIKVFANG-TLVVKSV 2211
L L+C A+G P P I+W L +++ A + +D ++ G +L +
Sbjct: 1318 LTLECDANGFPVPEIVW-LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRI 1376
Query: 2212 TDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLP 2271
+ D+G Y C A N+ G + V+ P+ + + G D+++ C +G+P
Sbjct: 1377 QEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVP 1436
Query: 2272 NPEISWS------LPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCF 2325
P++ W+ LP G + +Q D G+ R + G +EG Y C
Sbjct: 1437 TPQVEWTKDRQPVLPGGPHLQ--VQED---GQVLRITGSHVG----------DEGRYQCV 1481
Query: 2326 AENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTN 2385
A + G+ +++V P + V V +V + CEA+G P P +TW
Sbjct: 1482 AFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFK-DG 1540
Query: 2386 KVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGN 2445
++PTS++ L + +AQ SD+G YTC N+ G K + V V PP I G
Sbjct: 1541 ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV-PPTIEGA 1599
Query: 2446 PNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGS-LD 2504
V+ +A G ++C A G P+P + W EG+ + N + +GS L
Sbjct: 1600 GGRPYVVKAVA--GRPVALECVARGHPSPTLSW-HHEGLPVAE---SNESRLETDGSVLR 1653
Query: 2505 IRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNC 2564
+ S ++ S C+A + GEA +LQ +V + + ++T + G + L C
Sbjct: 1654 LESPGEASSGLYSCVASSPAGEA--VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 1711
Query: 2565 SAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADG-MLHISGLSSVDAGAYRCVARNAAG 2623
A+G+P P++ W L NG + ++L + G LHI + +G + C A N AG
Sbjct: 1712 QASGSPVPTIQW-LQNG---RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 1767
Query: 2624 HTERLVSLKV------GLKPEANKQYHNLVSIINGETLKLPCTPP-GAGQGRF------- 2669
V + V G+ QYH + + C PP G G
Sbjct: 1768 TAGAEVEVSVHGEWAPGVLEVPIGQYH--WGXEHHSSFPAACDPPVHRGWGAHPKPPLVE 1825
Query: 2670 SWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVI 2729
W P L G T V+ L + + + D G Y C G S + + V+
Sbjct: 1826 GWCSPGS--LWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL 1883
Query: 2730 AYPPRITSEPTPVIYTRPGN-TVKLNCMAMGIPKADITW---ELPDKSHLKAGVQARLYG 2785
PP I EP PV N +V L C+A G+P D++W P S + GV + G
Sbjct: 1884 V-PPNI--EPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWM--GVTVSVDG 1938
Query: 2786 NRFLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
L I+ A DAG Y+C+A N+ GS
Sbjct: 1939 R-------VLRIEQAQLSDAGSYRCVASNVAGS 1964
Score = 271 bits (692), Expect = 9e-72
Identities = 291/1092 (26%), Positives = 435/1092 (39%), Gaps = 156/1092 (14%)
Query: 1819 ITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQI-LTKSPQTVSVTAETDTVFPCEA 1877
I+ + + G +Q + G AS + + E PQ+ + S Q S E C A
Sbjct: 574 ISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKV--SCSA 631
Query: 1878 TGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLD 1937
+G P P ++W++ S AL + R V GTL+I+ V +D G Y C A+N G D
Sbjct: 632 SGYPTPHISWSRESQ-ALQEDS----RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 686
Query: 1938 RMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSP 1997
+ V L T P +++ V V +G+ + C A G P P++ W R + +
Sbjct: 687 QETVTLYYT--DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY---RGGLEMILA 741
Query: 1998 VEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENI 2057
EG + L I A D G Y C A N G S I+L V P + E ++
Sbjct: 742 PEGS----SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT--ELPRDV 795
Query: 2058 SLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI-------RPSQFLHGNLFVFPNGTLYIR 2110
++ G S + C A P P+V W GDG + R S+ + +G L+
Sbjct: 796 TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD-----SGVLFFE 850
Query: 2111 NLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSA 2170
++AP+D Y C A N+ G + +L V A +I ++P V G + L C
Sbjct: 851 SVAPEDQAPYVCEARNVFGKVQAEARLIVT-GHAPPQIASSAPT-VRVLEGQPVSLPCIV 908
Query: 2171 -SGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD 2229
+G P P W + + SR + A+G+L + + AG Y CVA N G
Sbjct: 909 LAGRPLPERHWLKDGRPLPPG-----SRHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 963
Query: 2230 DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFM 2289
+ +++ VV P +I H H G + CVA+G+P P I+W+ +L +
Sbjct: 964 QHRDVEL-VVQVPPRI-HPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTS--- 1018
Query: 2290 QSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKV-------- 2341
R Y V GTL + ++ G Y C A N VG +R+ V
Sbjct: 1019 -------RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKY 1071
Query: 2342 -----------------------------VTAPATIRNKTY-LAVQVP------------ 2359
+ PA + Y L VQVP
Sbjct: 1072 VWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKV 1131
Query: 2360 -YGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTC 2418
G+ + + C A+G P P+++W S V+ + G++ + SD+G Y C
Sbjct: 1132 LVGEALDLNCVAEGNPEPQLSW-SKDGVVLQGRGPQ------GSVHFAAIRTSDAGRYRC 1184
Query: 2419 LVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLW 2478
NSAG D V + V ++PP + + + + E AG + L C A G P P+V W
Sbjct: 1185 EASNSAGVDAWEVELRV-LEPP--HWGADETSGLLERVAGENASL-PCPARGTPKPQVTW 1240
Query: 2479 AFPEGVVLPAPYYGNR-ITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLE 2537
P +G + V GSL + S+ +DS C A NE G +L V
Sbjct: 1241 RKGPS---SEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYV 1297
Query: 2538 PMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPN------------GTDLQ 2585
P I D ++ MAG +++L C A G P P +VW+ G DL
Sbjct: 1298 PPS--IREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLG 1355
Query: 2586 SGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEA-NKQYH 2644
GQ LH + D+G Y C A N AG +R L V P
Sbjct: 1356 WGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAA 1415
Query: 2645 NLVSIINGETLKLPCTPPGAGQGRFSWT------LPNGMHLEGPQTLGRVSLLDNGTLTV 2698
V + G ++L C G + WT LP G HL+ + D L +
Sbjct: 1416 QEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQE--------DGQVLRI 1467
Query: 2699 REASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAM 2758
+ V D G Y C + G + V A P S T + + V+L C A
Sbjct: 1468 TGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEAR 1527
Query: 2759 GIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQ--HATQRDAGFYKCMAKNIL 2816
G+P +ITW D + L + ++ +G +Q A DAG Y C A N +
Sbjct: 1528 GVPTPNITW-FKDGALLPTSTKV-------VYTRGGRQLQLGRAQSSDAGVYTCKASNAV 1579
Query: 2817 GSDSKTTYIHVF 2828
G+ K T + V+
Sbjct: 1580 GAAEKATRLDVY 1591
Score = 270 bits (690), Expect = 1e-71
Identities = 230/809 (28%), Positives = 358/809 (44%), Gaps = 83/809 (10%)
Query: 1856 LTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVI 1915
+ P V+V+ + PC+A G P P V+W K + + R RFE+L G+L I
Sbjct: 3675 IRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK----DRVPLDPRSPRFEILPEGSLRI 3730
Query: 1916 RKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAK 1975
+ V QD G Y+C ASN G DR + V +P +A ++T+ + C A
Sbjct: 3731 QPVLAQDAGHYLCLASNSAGSDRQG--RDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 3788
Query: 1976 GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS 2035
G+P P + W +++ + +G L + L + D ++CV SN G
Sbjct: 3789 GSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE-- 3844
Query: 2036 LAIRLH--VAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI--RP 2091
A RL+ +PP I ++ + ++ + + C + P P+V W G Q+ R
Sbjct: 3845 -AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVVLTCHSTGIPAPTVSWSKA-GAQLGARG 3901
Query: 2092 SQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGT 2151
S + V P+G L I P +GRY C A N G A + V L VQ + +
Sbjct: 3902 SGYR-----VSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP----VVKP 3952
Query: 2152 SPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSV 2211
P + L C ASG P P I W+ + + + +V G L +
Sbjct: 3953 LPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQLRIAHA 4007
Query: 2212 TDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLP 2271
+ +DAG+YLC+A+N G ++ VV P IE+ D G + C A G P
Sbjct: 4008 SPEDAGNYLCIAKNSAGSAMGKTRL-VVQVPPVIENGLP-DLSTTEGSHAFLPCKARGSP 4065
Query: 2272 NPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG 2331
P I+W DG V+ G ++ + +G L + ++ G YTC AEN VG
Sbjct: 4066 EPNITWD-KDGQPVS---------GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG 4115
Query: 2332 KDEMRVRVKVVTAP--ATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIP 2389
+ RV + ++ P T+ L + GD + + C A+G P P++ W V
Sbjct: 4116 RARRRVHLTILVLPVFTTLPGDRSLRL----GDRLWLRCAARGSPTPRIGWTVNDRPVTE 4171
Query: 2390 TSSEKYQIYQDGTLLIQKA--QRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPN 2447
SE QDG +Q+A R DSG Y C N G + ++HV + P + G
Sbjct: 4172 GVSE-----QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK-EAPVLQGEAF 4225
Query: 2448 PITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRS 2507
GGS +L DC G P P + W +G+ L + +++ NGSL I
Sbjct: 4226 SYLVE---PVGGSIQL-DCVVRGDPVPDIHW-IKDGLPLRGSHLRHQLQ---NGSLTIHR 4277
Query: 2508 LRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH-DPISEKITAMAGHTISLNCSA 2566
+ D+ + C+A NE G A+ ++ +L P+F +P + +T +G ++L C A
Sbjct: 4278 TERDDAGRYQCLAENEMGVAK---KVVILVLQSAPVFQVEP--QDMTVRSGDDVALRCQA 4332
Query: 2567 AGTPTPSLVWVLPNGTDLQSGQQL---QRFYHKADGMLHISGLSSVDAGAYRCVARNAAG 2623
G PTP++ W LQ+GQ L +R DG L + + + DAG Y CVA N G
Sbjct: 4333 TGEPTPTIEW-------LQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLG 4385
Query: 2624 HTERLVSLKVGLKPEANKQYHNLVSIING 2652
L V +P+ + + ++ +ING
Sbjct: 4386 SATARAFLVVRGEPQGS--WGSMTGVING 4412
Score = 267 bits (682), Expect = 1e-70
Identities = 265/1013 (26%), Positives = 414/1013 (40%), Gaps = 93/1013 (9%)
Query: 1853 PQILTKSPQTVSVTA--ETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
P+++ ++TA + CEA G P P + W + +T + L
Sbjct: 2350 PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYL-----LAG 2404
Query: 1911 GTLV-IRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYL-GDTI 1968
G ++ + + Q QD G Y C ASN G R + V V P I ++V L G T
Sbjct: 2405 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP-PSIENEDLEEVIKVLDGQTA 2463
Query: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS 2028
+ C G P P+++W F D R ++ + + L + +A+ S G Y C+A+
Sbjct: 2464 HLMCNVTGHPQPKLTW-FKDGR---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAA 2519
Query: 2029 NAAGADSLAIRLHVAALPPVI---HQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD 2085
NA G + +L V P ++ E +++ I + C A A P P++ W + D
Sbjct: 2520 NAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW-MKD 2578
Query: 2086 GTQIRPSQFLHGNLFVFPNGT--LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
G S+ N+ + P GT L I N +D+G+Y CV N +G A + + V
Sbjct: 2579 GAPFEASR----NIQLLP-GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 2633
Query: 2144 ANAR---ITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV 2200
+ ++ + + + TL L+C + P P I W + + + SR++V
Sbjct: 2634 SISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPS-----SRLQV 2688
Query: 2201 FANGTLV-VKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPA-----------KIEHK 2248
G L+ ++ D+G YLCVA N G+D V + + P +I +
Sbjct: 2689 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSR 2748
Query: 2249 EENDH-------KVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
EE ++ + C +P P+++W D L S GGR
Sbjct: 2749 EEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRV--- 2805
Query: 2302 VVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA--VQVP 2359
L V G Y+C A N+VG+D + + V+T P + + L V V
Sbjct: 2806 -------LQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVN 2858
Query: 2360 YGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTC 2418
V++ C A G P+P ++WL N + + S + Q+ +DG +L + A+ +D+ +Y C
Sbjct: 2859 ASSTVSLQCPALGNPVPTISWLQ--NGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMC 2916
Query: 2419 LVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLW 2478
+ N AG K + V V PP+I G + + A S + C P P V W
Sbjct: 2917 VAENQAGSAEKLFTLRVQV-PPRIAG----LDLEQVTAILNSSVSLPCDVHAHPNPEVTW 2971
Query: 2479 AFPEGVVLPAPYYGNRI-TVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLE 2537
+ + L G + + G +L + R SDS C A N G + ++QL+VL
Sbjct: 2972 -YKDSQALSL---GEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 3027
Query: 2538 PMEKPIFHDPI---SEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFY 2594
P P F + + G L+C P P++ W +G L Q+ Q
Sbjct: 3028 P---PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWY-KDGQPLVLAQRTQAL- 3082
Query: 2595 HKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGET 2654
+ L I D G Y C N AG R +L V + P VS + G
Sbjct: 3083 -RGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSP 3141
Query: 2655 LKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRME 2714
L L C G +W L + M +E G VS G L + GTY C E
Sbjct: 3142 LVLTCDVSGVPAPTVTW-LKDRMPVESSAVHGVVSR--GGRLQLSRLQPAQAGTYTCVAE 3198
Query: 2715 TEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSH 2774
+ V V+ P +S + G V+L+C A G P D+ W L D S
Sbjct: 3199 NTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW-LKDGSP 3257
Query: 2775 LKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
L + L RF GSL ++ DAG Y C+A N G D++ ++V
Sbjct: 3258 LGQDMGPHL---RFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNV 3307
Score = 263 bits (672), Expect = 2e-69
Identities = 263/1011 (26%), Positives = 404/1011 (39%), Gaps = 116/1011 (11%)
Query: 1853 PQIL--TKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
PQI + P VSV + C ATGKP P VTW + ++Q +
Sbjct: 2256 PQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQN----QG 2311
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILAS--HYQDVTVYLGDTI 1968
+L + + Q G+Y C A NL G LSV V P+++ ++T L +
Sbjct: 2312 QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVP-PELIGDLDPLTNITAALHSPL 2370
Query: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS 2028
+ C A G P P I W R + VSP E L L + + D G+Y C+AS
Sbjct: 2371 TLLCEAMGIPPPAIRWF----RGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS 2426
Query: 2029 NAAGADSLAIRLHVAALPPVIHQEKLEN-ISLPPGLSIHIHCTAKAAPLPSVRWVLGDGT 2087
N AG + V +PP I E LE I + G + H+ C P P + W DG
Sbjct: 2427 NEAGEARRNFSVEV-LVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTW-FKDGR 2484
Query: 2088 QIRPSQFLHGNLFVFPNGT-LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANA 2146
+ H + P+G L + +G Y C+AAN VG + QL+V A
Sbjct: 2485 PLARGDAHH----ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT-- 2538
Query: 2147 RITGTSPRRTD----VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFA 2202
I G + D V + L C A P P I W M D SR
Sbjct: 2539 -ILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITW------MKDGAPFEASRNIQLL 2591
Query: 2203 NGT--LVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPA-----KIEHKEENDHKV 2255
GT L + + +DAG Y CV N++G+ V+V++ P+ + + K
Sbjct: 2592 PGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKT 2651
Query: 2256 FYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG-TLYFNEV 2314
L ++C + +P P I W DG V + R V G L
Sbjct: 2652 KVNSTLTLECESWAVPPPTIRW-YKDGQPVTP----------SSRLQVLGEGRLLQIQPT 2700
Query: 2315 GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAV-------------QVPYG 2361
+ + G Y C A N G+D+ V + P + + A Y
Sbjct: 2701 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 2760
Query: 2362 DVVT-----VACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGN 2415
++V + C+ P P +TW + ++ ++ + Q G +L I + ++G
Sbjct: 2761 EIVENNPAYLYCDTNAIPPPDLTWYREDQPL--SAGDEVSVLQGGRVLQIPLVRAENAGR 2818
Query: 2416 YTCLVRNSAGEDRKTVWIHVN---VQPPKINGNPNPITTVREIAAGGSRKL-IDCKAEGI 2471
Y+C N GED W+H + PP I G+ + V E+ S + + C A G
Sbjct: 2819 YSCKASNEVGED----WLHYELLVLTPPVILGDTEEL--VEEVTVNASSTVSLQCPALGN 2872
Query: 2472 PTPRVLWAFPEGVVLPAPYYGNRITVHGNGS-LDIRSLRKSDSVQLVCMARNEGGEARLI 2530
P P + W P+P R+ V +G L + + +D+ +C+A N+ G A +
Sbjct: 2873 PVPTISWLQNGLPFSPSP----RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKL 2928
Query: 2531 LQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQL 2590
L V P P E++TA+ ++SL C P P + W + L G+++
Sbjct: 2929 FTLRVQVP---PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTW-YKDSQALSLGEEV 2984
Query: 2591 QRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP---EANKQYHNLV 2647
F L + D+G Y C A NAAG ++LV L V + P +A + + V
Sbjct: 2985 --FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAV 3042
Query: 2648 SIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNG-TLTVREASVFDR 2706
+ G+ L C + +W +G L Q R L G L ++EA V D+
Sbjct: 3043 LVRVGDKAVLSCETDALPEPTVTW-YKDGQPLVLAQ---RTQALRGGQRLEIQEAQVSDK 3098
Query: 2707 GTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADIT 2766
G Y C++ G +V + + + PP + T + G+ + L C G+P +T
Sbjct: 3099 GLYSCKVSNVAGEAVRTF-TLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVT 3157
Query: 2767 W---ELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKN 2814
W +P +S GV +R G L + AG Y C+A+N
Sbjct: 3158 WLKDRMPVESSAVHGVVSR---------GGRLQLSRLQPAQAGTYTCVAEN 3199
Score = 246 bits (627), Expect = 3e-64
Identities = 235/910 (25%), Positives = 368/910 (40%), Gaps = 79/910 (8%)
Query: 1858 KSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRK 1917
+ P+ V A V C +P P +TW + G ++ + Q E + L ++
Sbjct: 3586 RGPRFVVGLAPGQLVLECSVEAEPAPKITWHR--DGIVLQEDAHTQFPE--RGRFLQLQA 3641
Query: 1918 VQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGT 1977
+ D G Y CTA N G V V + + S V V + T + C A G
Sbjct: 3642 LSTADSGDYSCTARNAAGSTS--VAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 3699
Query: 1978 PAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLA 2037
PAP +SW R+ + P R + +L I+ D G Y C+ASN+AG+D
Sbjct: 3700 PAPLVSW----RKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQG 3755
Query: 2038 IRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHG 2097
L V PP I N++L + C A +P P V W DG ++ + G
Sbjct: 3756 RDLRVLE-PPAIAPSP-SNLTLTAHTPALLPCEASGSPKPLVVW-WKDGQKL-DFRLQQG 3811
Query: 2098 NLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTD 2157
+ P+ L + P+DS ++ECV +N VG A R Q+ V A +TD
Sbjct: 3812 AYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIA------DDQTD 3865
Query: 2158 --VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKD 2215
V + L C ++G P P + W + L + S +V +G L +
Sbjct: 3866 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQ----LGARGSGYRVSPSGALEIGQALPIH 3921
Query: 2216 AGDYLCVARNKVG----DDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLP 2271
AG Y C ARN G ++ ++ V+KP + + +V + C A+G+P
Sbjct: 3922 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVL------LPCEASGIP 3975
Query: 2272 NPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG 2331
P I+W +G V + + + V G L + G+Y C A+N G
Sbjct: 3976 RPTITWQ-KEGLNVATGVSTQ----------VLPGGQLRIAHASPEDAGNYLCIAKNSAG 4024
Query: 2332 KDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTS 2391
+ R+ VV P I N + G + C+A+G P P +TW + + +
Sbjct: 4025 SAMGKTRL-VVQVPPVIENGLP-DLSTTEGSHAFLPCKARGSPEPNITW-DKDGQPVSGA 4081
Query: 2392 SEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITT 2451
K+ I G LL++ + D+G YTC N+ G R+ V + + V P TT
Sbjct: 4082 EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPV--------FTT 4133
Query: 2452 V---REIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSL 2508
+ R + G R + C A G PTPR+ W V P G +L ++
Sbjct: 4134 LPGDRSLRLG-DRLWLRCAARGSPTPRIGWT-----VNDRPVTEGVSEQDGGSTLQRAAV 4187
Query: 2509 RKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAG 2568
+ DS VC A N G + + + + E P+ + G +I L+C G
Sbjct: 4188 SREDSGTYVCWAENRVGRTQAV---SFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRG 4244
Query: 2569 TPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERL 2628
P P + W+ +G L+ G L+ + +G L I DAG Y+C+A N G +++
Sbjct: 4245 DPVPDIHWI-KDGLPLR-GSHLR--HQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKV 4300
Query: 2629 VSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRV 2688
V L + P + ++ ++ +G+ + L C G W L G L + R+
Sbjct: 4301 VILVLQSAPVFQVEPQDM-TVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRASR---RL 4355
Query: 2689 SLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPG 2748
L +G+L + D GTY C G + ++V P T VI R
Sbjct: 4356 RTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVINGRKF 4415
Query: 2749 NTVKLNCMAM 2758
LN M
Sbjct: 4416 GVATLNTSVM 4425
Score = 244 bits (623), Expect = 9e-64
Identities = 271/1104 (24%), Positives = 412/1104 (37%), Gaps = 169/1104 (15%)
Query: 1811 STQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETD 1870
S SS + +S G++ ++ G ++ PQ++ TVS ET
Sbjct: 476 SGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVS-PGET- 533
Query: 1871 TVFPCEATGKPKPFVTWTK------VSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRG 1924
V C G+ +TW + STG R L + +L I + D G
Sbjct: 534 AVLSCRVLGEAPYNLTWVRDWRVLPASTG----------RVAQLADLSLEISGIIPTDGG 583
Query: 1925 QYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISW 1984
+Y C ASN +G+ R V L V + PQ+ + H G + + C A G P P ISW
Sbjct: 584 RYQCVASNANGVTRASVWLLVR-EAPQV-SIHTSSQHFSQGVEVKVSCSASGYPTPHISW 641
Query: 1985 IFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAA 2044
+ + + + RI + TL I+ + D G Y C A+N G D + L+
Sbjct: 642 SRESQALQE-----DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD 696
Query: 2045 LPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPN 2104
P V + +++ G + C A P P V W G I + G+ +
Sbjct: 697 PPSVSAVNAVVLVAV--GEEAVLVCEASGVPPPRVIWYRGGLEMILAPE---GS----SS 747
Query: 2105 GTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTL 2164
G L I +D+G Y C A N +G A +QL V A + PR V G +
Sbjct: 748 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTEL----PRDVTVELGRSA 803
Query: 2165 KLDCSASGDPWPRILWRLPSKRMIDALFSFD--SRIKVFANGTLVVKSVTDKDAGDYLCV 2222
L C A+G P P + WR + + SR + +G L +SV +D Y+C
Sbjct: 804 LLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 863
Query: 2223 ARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVA-TGLPNPEISW---- 2277
ARN G ++ V +V G + + C+ G P PE W
Sbjct: 864 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 923
Query: 2278 -SLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMR 2336
LP GS R+ + +G+L+ + G Y+C A N G
Sbjct: 924 RPLPPGS----------------RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRD 967
Query: 2337 VRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQ 2396
V + V P T+ G ++ C A G P P +TW TN + + Y
Sbjct: 968 VELVVQVPPRIHPTATHHITNE--GVPASLPCVASGVPAPTITWTKETN-ALTSRGPHYN 1024
Query: 2397 IYQDGTLLIQKAQRSDSGNYTCLVRNSAGED-------------RKTVWIHVNVQPP--- 2440
+ ++GTLLI + D+G Y C N+ G K VW + P
Sbjct: 1025 VSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSL 1084
Query: 2441 -----KINGNPNPITTVREIAAGGSRKLI--------------------------DCKAE 2469
++ + + T A S + + +C AE
Sbjct: 1085 RLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAE 1144
Query: 2470 GIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARL 2529
G P P++ W+ +GVVL GS+ ++R SD+ + C A N G
Sbjct: 1145 GNPEPQLSWS-KDGVVLQGR--------GPQGSVHFAAIRTSDAGRYRCEASNSAGVDAW 1195
Query: 2530 ILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQ 2589
++L VLEP D S + +AG SL C A GTP P + W ++ GQ
Sbjct: 1196 EVELRVLEPPHWGA--DETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQP 1253
Query: 2590 LQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNL-VS 2648
+G L ++ +S D+G Y C A N G T R L V + P + VS
Sbjct: 1254 GVAVLE--EGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVS 1311
Query: 2649 IINGETLKLPCTPPG------------------AGQGRFSWTLPNGMHLEGPQTLGRVSL 2690
+ G++L L C G G + W L G +G L
Sbjct: 1312 GMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQ-------VGGHRL 1364
Query: 2691 LDNG-TLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGN 2749
LD G +L D G Y CR E + G + ++V+ P + + + G
Sbjct: 1365 LDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGA 1424
Query: 2750 TVKLNCMAMGIPKADITWE------LPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQR 2803
V+L C G+P + W LP HL+ ++ L I +
Sbjct: 1425 DVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV-----------LRITGSHVG 1473
Query: 2804 DAGFYKCMAKNILGSDSKTTYIHV 2827
D G Y+C+A + G ++ + V
Sbjct: 1474 DEGRYQCVAFSPAGQQARDFQLRV 1497
Score = 239 bits (611), Expect = 2e-62
Identities = 279/1086 (25%), Positives = 413/1086 (38%), Gaps = 125/1086 (11%)
Query: 1785 PAPPLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPAS 1844
P PPL+ + GS IP+ S + ++ G + +++ AG
Sbjct: 1819 PKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNL-AGESKRE 1877
Query: 1845 KFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTK----VST--GALMTP 1898
+ P I P +V C A+G P P V+W K VS+ G ++
Sbjct: 1878 VALKVLVPPNI-EPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV 1936
Query: 1899 NTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQ 1958
+ R+ R E + Q+ D G Y C ASN+ G + L V V P+I
Sbjct: 1937 DGRVLRIE----------QAQLSDAGSYRCVASNVAGSTELRYGLRVNVP-PRITLPPSL 1985
Query: 1959 DVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFS 2018
V + + + C A G P+P + W+ V +P G R L++ A S
Sbjct: 1986 PGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTP--GLQVFPGGRVLTLASARAS 2043
Query: 2019 DRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPS 2078
D G Y CVA +A G D + L V +PP I E+L N+S+ S+ + C + A P P
Sbjct: 2044 DSGRYSCVAVSAVGEDRQDVVLQV-HMPPSILGEEL-NVSVVANESVALECQSHAMPPPV 2101
Query: 2079 VRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLN 2138
+ W DG + P +H L + D+G Y C A N G + + LN
Sbjct: 2102 LSW-WKDGRPLEPRPGVH---LSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLN 2157
Query: 2139 VQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR-----LPSKRMIDALFS 2193
V A VR G L C G P+P+I WR LP + S
Sbjct: 2158 VWVAPV---FPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVS 2214
Query: 2194 FDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKE-END 2252
R+ L G Y C N VG+ L+++V + P +E
Sbjct: 2215 AVGRLLYLGQAQLA-------QEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQ 2267
Query: 2253 HKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFN 2312
V G ++C ATG P P ++W DG V G + +L+
Sbjct: 2268 VSVVQDGVATLECNATGKPPPTVTWE-RDGQPV---------GAELGLQLQNQGQSLHVE 2317
Query: 2313 EVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA-VQVPYGDVVTVACEAK 2371
G Y+C AEN G+ E + + V+ P I + L + +T+ CEA
Sbjct: 2318 RAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAM 2377
Query: 2372 GEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTV 2431
G P P + W V P + Y + L + + Q DSG Y+CL N AGE R+
Sbjct: 2378 GIPPPAIRWFRGEEPVSP-GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNF 2436
Query: 2432 WIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYY 2491
+ V V P N + + V + G + C G P P++ W F +G L
Sbjct: 2437 SVEVLVPPSIENEDLEEVIKVLD----GQTAHLMCNVTGHPQPKLTW-FKDGRPLAR--- 2488
Query: 2492 GNRITVHGNG-SLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV-LEPMEKPIFHDPIS 2549
G+ + +G L + S + C+A N GE QL+V L P D
Sbjct: 2489 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 2548
Query: 2550 EKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSV 2609
E++T + ISL C A P+P++ W + +G ++ + +Q L I
Sbjct: 2549 EEVTVTVNNPISLICEALAFPSPNITW-MKDGAPFEASRNIQLL--PGTHGLQILNAQKE 2605
Query: 2610 DAGAYRCVARNAAGHTERLVSLKVGLKPEANKQ-------YHNLVSIINGETLKLPCTPP 2662
DAG Y CV N G + ++V + P +K + + +N TL L C
Sbjct: 2606 DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN-STLTLECE-- 2662
Query: 2663 GAGQGRFSWTLPN---GMHLEG-PQT-LGRVSLLDNG-TLTVREASVFDRGTYVCRMETE 2716
SW +P + +G P T R+ +L G L ++ V D G Y+C
Sbjct: 2663 -------SWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 2715
Query: 2717 YGPSVTSIPVIVIAYPPRI----------------------TSEPTPVIYTRPGNTVKLN 2754
G V+ I PP +E ++ P L
Sbjct: 2716 AGEDDQDFNVL-IQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNP---AYLY 2771
Query: 2755 CMAMGIPKADITWELPDKSHLKAGVQAR-LYGNRFLHPQGSLTIQHATQRDAGFYKCMAK 2813
C IP D+TW D+ L AG + L G R L I +AG Y C A
Sbjct: 2772 CDTNAIPPPDLTWYREDQP-LSAGDEVSVLQGGRVLQ------IPLVRAENAGRYSCKAS 2824
Query: 2814 NILGSD 2819
N +G D
Sbjct: 2825 NEVGED 2830
Score = 231 bits (588), Expect = 1e-59
Identities = 258/1058 (24%), Positives = 417/1058 (39%), Gaps = 128/1058 (12%)
Query: 1821 SSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGK 1880
+ VQ S H + G + ++ + P + P+ + V C A G
Sbjct: 1087 AQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGN 1146
Query: 1881 PKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMV 1940
P+P ++W+K G ++ G++ ++ D G+Y C ASN G+D
Sbjct: 1147 PEPQLSWSK--DGVVLQGRG--------PQGSVHFAAIRTSDAGRYRCEASNSAGVDAWE 1196
Query: 1941 VLLSVTVQQPQILASHYQDVTVYL-GDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVE 1999
V L V ++ P A + + G+ ++ C A+GTP PQ++W R + P+
Sbjct: 1197 VELRV-LEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTW-----RKGPSSEPLH 1250
Query: 2000 GR--ITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENI 2057
G+ + + E +L + S +D G Y+C A+N G+ S +L V P + + N+
Sbjct: 1251 GQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANV 1310
Query: 2058 SLPPGLSIHIHCTAKAAPLPSVRWV------------LGDGTQIRPSQFLHGNLFVFPNG 2105
S G S+ + C A P+P + W+ G G + Q + G+ +
Sbjct: 1311 SGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQ-VGGHRLLDEGQ 1369
Query: 2106 TLYIRNLAPKDSGRYECVAANLVGSARRTVQL------NVQRAAANARITGTSPRRTDVR 2159
+L+ + DSG Y C A N G+A+R L +V A A + G +
Sbjct: 1370 SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLA------- 1422
Query: 2160 YGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANG-TLVVKSVTDKDAGD 2218
G ++L C SG P P++ W + ++ ++V +G L + D G
Sbjct: 1423 -GADVELQCWTSGVPTPQVEWTKDRQPVLPG----GPHLQVQEDGQVLRITGSHVGDEGR 1477
Query: 2219 YLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWS 2278
Y CVA + G ++ V P E + V +++ C A G+P P I+W
Sbjct: 1478 YQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW- 1536
Query: 2279 LPDGSLVNSFMQSDDSGGRTKRYVVFNNG--TLYFNEVGMREEGDYTCFAENQVGKDEMR 2336
DG+L+ T VV+ G L + G YTC A N VG E
Sbjct: 1537 FKDGALL-----------PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA 1585
Query: 2337 VRVKVVTAPAT--IRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTS-SE 2393
R+ V P + Y+ V+ G V + C A+G P P ++W ++ +P + S
Sbjct: 1586 TRLDVYVPPTIEGAGGRPYV-VKAVAGRPVALECVARGHPSPTLSW---HHEGLPVAESN 1641
Query: 2394 KYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNP-NPITT 2451
+ ++ DG++L ++ + SG Y+C+ + AGE + V V P + +TT
Sbjct: 1642 ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTT 1701
Query: 2452 VREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKS 2511
+ G + C+A G P P + W G PA +L I +
Sbjct: 1702 I-----VGQPLELPCQASGSPVPTIQW-LQNG--RPAEELAGVQVASQGTTLHIDHVELD 1753
Query: 2512 DSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGH-TISLNCS----- 2565
S C A NE G A ++++V + PI + H + C
Sbjct: 1754 HSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHR 1813
Query: 2566 ----------AAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYR 2615
G +P +W P G + + L I + D G Y
Sbjct: 1814 GWGAHPKPPLVEGWCSPGSLWGEPTGIPVA---------YSLPPPLQIEKVDLRDEGIYT 1864
Query: 2616 CVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPN 2675
C A N AG ++R V+LKV + P N +++ ++ L C G SW
Sbjct: 1865 CAATNLAGESKREVALKVLVPPNIEPGPVN-KAVLENASVTLECLASGVPPPDVSWFKG- 1922
Query: 2676 GMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRI 2735
H +G +D L + +A + D G+Y C G + + + PPRI
Sbjct: 1923 --HQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-LRVNVPPRI 1979
Query: 2736 T---SEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLH-- 2790
T S P PV+ P V+L C A G P + W LK G G L
Sbjct: 1980 TLPPSLPGPVLVNTP---VRLTCNATGAPSPTLMW-------LKDGNPVSPAGTPGLQVF 2029
Query: 2791 PQGS-LTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
P G LT+ A D+G Y C+A + +G D + + V
Sbjct: 2030 PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV 2067
Score = 230 bits (586), Expect = 2e-59
Identities = 259/994 (26%), Positives = 370/994 (37%), Gaps = 100/994 (10%)
Query: 1874 PCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNL 1933
PC A G PKP VTW K G P VL+ G+L + V D G Y C A+N
Sbjct: 1227 PCPARGTPKPQVTWRK---GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNE 1283
Query: 1934 HGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQ 1993
G L V V +V+ G ++ +EC A G P P+I W+ + V
Sbjct: 1284 VGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGV 1343
Query: 1994 TVS-----------PVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHV 2042
+ V G L E ++L D G+Y C A N AG L V
Sbjct: 1344 PLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLV 1403
Query: 2043 AALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVF 2102
P V+ + + G + + C P P V W D + P +L V
Sbjct: 1404 LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK-DRQPVLPGG---PHLQVQ 1459
Query: 2103 PNG-TLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPR-RTDVRY 2160
+G L I D GRY+CVA + G R QL V A I G++ V
Sbjct: 1460 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH---APPTIWGSNETGEVAVME 1516
Query: 2161 GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGT-LVVKSVTDKDAGDY 2219
++L C A G P P I W AL +++ G L + DAG Y
Sbjct: 1517 DHLVQLLCEARGVPTPNITWFKDG-----ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVY 1571
Query: 2220 LCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDH--KVFYGGDLKVDCVATGLPNPEISW 2277
C A N VG ++DV + P IE + K G + ++CVA G P+P +SW
Sbjct: 1572 TCKASNAVGAAEKATRLDVYVPPT-IEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW 1630
Query: 2278 ---SLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
LP S +++D S L G G Y+C A + G+
Sbjct: 1631 HHEGLPVAESNESRLETDGS-------------VLRLESPGEASSGLYSCVASSPAGEAV 1677
Query: 2335 MRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEK 2394
++ V+V P + + V G + + C+A G P+P + WL +
Sbjct: 1678 LQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAG-- 1735
Query: 2395 YQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQ-PPKINGNPN----- 2447
Q+ GT L I + SG + C N AG V + V+ + P + P
Sbjct: 1736 VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHW 1795
Query: 2448 --------PITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVV----LPAPYYGNRI 2495
P + G EG +P LW P G+ LP P
Sbjct: 1796 GXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP------ 1849
Query: 2496 TVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAM 2555
L I + D C A N GE++ + L VL P I P+++ +
Sbjct: 1850 -------LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN--IEPGPVNKAVLEN 1900
Query: 2556 AGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADG-MLHISGLSSVDAGAY 2614
A +++L C A+G P P + W + Q DG +L I DAG+Y
Sbjct: 1901 A--SVTLECLASGVPPPDVSWFKGH----QPVSSWMGVTVSVDGRVLRIEQAQLSDAGSY 1954
Query: 2615 RCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLP 2674
RCVA N AG TE L+V + P ++ ++L C GA W L
Sbjct: 1955 RCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMW-LK 2013
Query: 2675 NGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPR 2734
+G + T G LT+ A D G Y C + G + V+ + PP
Sbjct: 2014 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV-VLQVHMPPS 2072
Query: 2735 ITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGS 2794
I E V +V L C + +P ++W D L+ L ++ L
Sbjct: 2073 ILGEELNVSVVA-NESVALECQSHAMPPPVLSW-WKDGRPLEPRPGVHLSADKAL----- 2125
Query: 2795 LTIQHATQRDAGFYKCMAKNILGSDSKTTYIHVF 2828
L + A DAG Y C A N G K ++V+
Sbjct: 2126 LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVW 2159
Score = 229 bits (585), Expect = 2e-59
Identities = 190/682 (27%), Positives = 292/682 (42%), Gaps = 62/682 (9%)
Query: 1852 KPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG 1911
+P + SP +++TA T + PCEA+G PKP V W K G + + + +L +
Sbjct: 3762 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK--DGQKLDFRLQQGAYRLLPSN 3819
Query: 1912 TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAME 1971
L++ QD Q+ C SN G L VTV P +A D TV + + +
Sbjct: 3820 ALLLTAPGPQDSAQFECVVSNEVGEAHR--LYQVTVHVPPTIADDQTDFTVTMMAPVVLT 3877
Query: 1972 CLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAA 2031
C + G PAP +SW + + + + L I +A G Y C A N+A
Sbjct: 3878 CHSTGIPAPTVSW----SKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 3933
Query: 2032 GADSLAIRLHVAA------LPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD 2085
G + L V A LP V+ E + LP C A P P++ W +
Sbjct: 3934 GVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLP--------CEASGIPRPTITW-QKE 3984
Query: 2086 GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAAN 2145
G + + V P G L I + +P+D+G Y C+A N GSA +L VQ
Sbjct: 3985 GLNVATGV----STQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV- 4039
Query: 2146 ARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGT 2205
I P + G L C A G P P I W + + A + + + +G
Sbjct: 4040 --IENGLPDLSTTE-GSHAFLPCKARGSPEPNITWDKDGQPVSGA----EGKFTIQPSGE 4092
Query: 2206 LVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDC 2265
L+VK++ +DAG Y C A N VG + + +++ P + D + G L + C
Sbjct: 4093 LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLP--VFTTLPGDRSLRLGDRLWLRC 4150
Query: 2266 VATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCF 2325
A G P P I W++ D + + D GG TL V + G Y C+
Sbjct: 4151 AARGSPTPRIGWTVNDRPVTEGVSEQD--GG----------STLQRAAVSREDSGTYVCW 4198
Query: 2326 AENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTN 2385
AEN+VG+ + V V AP ++ + + + P G + + C +G+P+P + W+
Sbjct: 4199 AENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIK-DG 4256
Query: 2386 KVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGN 2445
+ S ++Q+ Q+G+L I + +R D+G Y CL N G +K V I V P
Sbjct: 4257 LPLRGSHLRHQL-QNGSLTIHRTERDDAGRYQCLAENEMGVAKKVV-ILVLQSAPVFQVE 4314
Query: 2446 PNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDI 2505
P +T G + C+A G PTP + W G L A R+ +GSL +
Sbjct: 4315 PQDMT-----VRSGDDVALRCQATGEPTPTIEW-LQAGQPLRA---SRRLRTLPDGSLWL 4365
Query: 2506 RSLRKSDSVQLVCMARNEGGEA 2527
++ D+ C+A N G A
Sbjct: 4366 ENVETGDAGTYDCVAHNLLGSA 4387
Score = 152 bits (383), Expect = 6e-36
Identities = 131/530 (24%), Positives = 208/530 (39%), Gaps = 35/530 (6%)
Query: 2296 GRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA 2355
G + + N + EEG Y C A ++ G + ++ V P + +
Sbjct: 468 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVT 527
Query: 2356 VQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
V G+ ++C GE +TW+ +V+P S+ + D +L I +D G
Sbjct: 528 VSP--GETAVLSCRVLGEAPYNLTWVRDW-RVLPASTGRVAQLADLSLEISGIIPTDGGR 584
Query: 2416 YTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPR 2475
Y C+ N+ G R +VW+ V + P+++ I T + + G + C A G PTP
Sbjct: 585 YQCVASNANGVTRASVWLLVR-EAPQVS-----IHTSSQHFSQGVEVKVSCSASGYPTPH 638
Query: 2476 VLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535
+ W+ A +RI V G+L I+ + D+ C A NE G + + L
Sbjct: 639 ISWSRES----QALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY 694
Query: 2536 LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYH 2595
+P ++ + G L C A+G P P ++W G ++ +
Sbjct: 695 TDPPSV----SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR-GGLEMILAPE-----G 744
Query: 2596 KADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETL 2655
+ G L I DAG Y C A N G + L VG P+ + + V++ G +
Sbjct: 745 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD-VTVELGRSA 803
Query: 2656 KLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLL---DNGTLTVREASVFDRGTYVCR 2712
L C G +W +G L GR S D+G L + D+ YVC
Sbjct: 804 LLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 863
Query: 2713 METEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAM-GIPKADITWELPD 2771
+G +IV + P + P + G V L C+ + G P LP+
Sbjct: 864 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP-------LPE 916
Query: 2772 KSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSK 2821
+ LK G + GSL + A Q AG Y C+A N GS +
Sbjct: 917 RHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHR 966
Score = 80.9 bits (198), Expect = 2e-14
Identities = 66/198 (33%), Positives = 92/198 (46%), Gaps = 12/198 (6%)
Query: 477 VMIEP---SGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFS 533
V++ P S V R+ VLEG +L C P + W L DGS L M P +F
Sbjct: 3212 VLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAW-LKDGSPLGQDMG-PHLRF- 3268
Query: 534 ILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKD-TVTIGKNPG 592
L G L +K + SD+G Y C+A D ++ V V P T D + T+ PG
Sbjct: 3269 YLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 3328
Query: 593 ESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCV 652
E VT+ C P H+SW+ + H TL I KVQ++D+G + CV
Sbjct: 3329 ELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHG---SGHTLRISKVQLADAGIFTCV 3385
Query: 653 AVNQQG-AD-HFTVGITV 668
A + G AD +FT+ + V
Sbjct: 3386 AASPAGVADRNFTLQVQV 3403
Score = 68.2 bits (165), Expect = 1e-10
Identities = 49/166 (29%), Positives = 75/166 (45%), Gaps = 12/166 (7%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLY 553
GG QL C V+ P I W+ DG L+ L +G L I E D+G Y
Sbjct: 4233 GGSIQLDCVVRGDPVPDIHWI-KDGLPLRG-----SHLRHQLQNGSLTIHRTERDDAGRY 4286
Query: 554 QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWIL 613
QC+A+ + + V +++QS E +T+ G+ V L C A P + W+
Sbjct: 4287 QCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTV--RSGDDVALRCQATGEPTPTIEWLQ 4344
Query: 614 PNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
+ L + + LP+G+L + V+ D+G Y CVA N G+
Sbjct: 4345 AGQ----PLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGS 4386
Score = 66.6 bits (161), Expect = 3e-10
Identities = 65/253 (25%), Positives = 103/253 (40%), Gaps = 17/253 (6%)
Query: 2578 LPNGTDLQSGQ----QLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV 2633
LP L+ G+ + + F + I S + G Y C A + AG + V
Sbjct: 454 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 513
Query: 2634 GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN 2693
P N V++ GET L C G +W + P + GRV+ L +
Sbjct: 514 TDPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLAD 569
Query: 2694 GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKL 2753
+L + D G Y C G + S+ ++V P S T + G VK+
Sbjct: 570 LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ--VSIHTSSQHFSQGVEVKV 627
Query: 2754 NCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAK 2813
+C A G P I+W ++ + +R++ + QG+L IQ DAG Y C A
Sbjct: 628 SCSASGYPTPHISWSRESQALQE---DSRIH----VDAQGTLIIQGVAPEDAGNYSCQAT 680
Query: 2814 NILGSDSKTTYIH 2826
N +G+D +T ++
Sbjct: 681 NEVGTDQETVTLY 693
Score = 66.6 bits (161), Expect = 3e-10
Identities = 49/169 (28%), Positives = 83/169 (49%), Gaps = 10/169 (5%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSG 551
L G L C+V+A +P I W DG +L+ +D ++F +L+++++ +DSG
Sbjct: 3594 LAPGQLVLECSVEAEPAPKITWHR-DGIVLQ---EDAHTQFPERGR-FLQLQALSTADSG 3648
Query: 552 LYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSW 611
Y C A+ + +RV + + T + V + N ++ LPC A +P +SW
Sbjct: 3649 DYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSW 3706
Query: 612 ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD 660
R+ D + +LP G+L I V D+G+Y C+A N G+D
Sbjct: 3707 --RKDRVPLD-PRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 3752
Score = 65.9 bits (159), Expect = 6e-10
Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 14/182 (7%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSD 549
VL P +L+CN + SP++ W L DG+ + +P P + G L + S SD
Sbjct: 1989 VLVNTPVRLTCNATGAPSPTLMW-LKDGNPV-SPAGTPG--LQVFPGGRVLTLASARASD 2044
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHL 609
SG Y C+A DR + V P + E+ V++ N ESV L C + A+P L
Sbjct: 2045 SGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVAN--ESVALECQSHAMPPPVL 2102
Query: 610 SWILPNRRIINDLANTSHVYM-LPNGTLSIPKVQVSDSGYYRCVAVNQQG--ADHFTVGI 666
SW R L V++ L + + V D+G+Y C A+NQ G H+ + +
Sbjct: 2103 SWWKDGR----PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV 2158
Query: 667 TV 668
V
Sbjct: 2159 WV 2160
Score = 65.1 bits (157), Expect = 9e-10
Identities = 57/208 (27%), Positives = 88/208 (42%), Gaps = 12/208 (5%)
Query: 463 ISTKDTRQARGRSWVMIEPSGAVQRDQ-TVLEGGPCQLSCNVKASESPSIFWVLPDGSIL 521
+S T +A+ + V P V TV G LSC V ++ WV D +L
Sbjct: 499 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVR-DWRVL 557
Query: 522 KAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAE 581
A + + L+ L I + P+D G YQC+A + + R +LV+
Sbjct: 558 PAST----GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH 613
Query: 582 KDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKV 641
+ + G V + C+A P H+SW ++ + D S +++ GTL I V
Sbjct: 614 TSSQHFSQ--GVEVKVSCSASGYPTPHISWSRESQALQED----SRIHVDAQGTLIIQGV 667
Query: 642 QVSDSGYYRCVAVNQQGADHFTVGITVT 669
D+G Y C A N+ G D TV + T
Sbjct: 668 APEDAGNYSCQATNEVGTDQETVTLYYT 695
Score = 63.2 bits (152), Expect = 4e-09
Identities = 55/205 (26%), Positives = 92/205 (44%), Gaps = 22/205 (10%)
Query: 480 EPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG- 538
E G V + ++E P L C+ A P + W D P+ D + S+L G
Sbjct: 2751 EARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED-----QPLSAGD-EVSVLQGGR 2804
Query: 539 WLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVT--IGKNPGESVT 596
L+I + ++G Y C A D + Y +LV +P + + + + N +V+
Sbjct: 2805 VLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVS 2864
Query: 597 LPCNALAIPEAHLSWI---LPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCV 652
L C AL P +SW+ LP + + + +L +G L + +V+D+ Y CV
Sbjct: 2865 LQCPALGNPVPTISWLQNGLP-------FSPSPRLQVLEDGQVLQVSTAEVADAASYMCV 2917
Query: 653 AVNQQGADH--FTVGITVTKKGSGL 675
A NQ G+ FT+ + V + +GL
Sbjct: 2918 AENQAGSAEKLFTLRVQVPPRIAGL 2942
Score = 63.2 bits (152), Expect = 4e-09
Identities = 57/222 (25%), Positives = 99/222 (44%), Gaps = 15/222 (6%)
Query: 477 VMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILS 536
V++ + + + TV L C + P+I W L +G P + +L
Sbjct: 2843 VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISW-LQNGLPFS-----PSPRLQVLE 2896
Query: 537 SGW-LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESV 595
G L++ + E +D+ Y C+A+ + ++ + VQ P + A D + SV
Sbjct: 2897 DGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPP-RIAGLDLEQVTAILNSSV 2955
Query: 596 TLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAV 654
+LPC+ A P ++W ++ L+ V++LP TL + + ++SDSG Y C A+
Sbjct: 2956 SLPCDVHAHPNPEVTWYKDSQA----LSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEAL 3011
Query: 655 NQQGADHFTVGITVTKKGSGLPSKRGRRPGAKALSRVREDIV 696
N G D V ++V + + RG P L RV + V
Sbjct: 3012 NAAGRDQKLVQLSVLVPPAFRQAPRG--PQDAVLVRVGDKAV 3051
Score = 61.6 bits (148), Expect = 1e-08
Identities = 55/219 (25%), Positives = 96/219 (43%), Gaps = 21/219 (9%)
Query: 477 VMIEPSGAVQRDQTVLE--GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSI 534
V + P+ + +TV + G P L+C+V +P++ W+ + P++ +
Sbjct: 3120 VQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKD-----RMPVESSAVHGVV 3174
Query: 535 LSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLV----QSPSTQPAEKDTVTIGKN 590
G L++ ++P+ +G Y C+A+ R + V V + S+ A + V
Sbjct: 3175 SRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVL---- 3230
Query: 591 PGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYR 650
G+ V L C A P ++W+ + D+ Y L G+L + ++ SD+G Y
Sbjct: 3231 EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY-LDGGSLVLKGLRASDAGAYT 3289
Query: 651 CVAVNQQGADH--FTVGITV---TKKGSGLPSKRGRRPG 684
CVA N G D TV + V K+G+ RPG
Sbjct: 3290 CVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 3328
Score = 61.2 bits (147), Expect = 1e-08
Identities = 51/202 (25%), Positives = 86/202 (42%), Gaps = 21/202 (10%)
Query: 463 ISTKDTRQARGRSWVMIEPSGAVQR---DQTVLEGGPCQLSCNVKASESPSIFWVLPDGS 519
I+ A G++ ++++ ++ D + EG L C + S P+I W DG
Sbjct: 4018 IAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWD-KDGQ 4076
Query: 520 ILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ-VRDEMDRMVYRVLVQSP--S 576
P+ + KF+I SG L +K++E D+G Y C A+ R V+ ++ P +
Sbjct: 4077 ----PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFT 4132
Query: 577 TQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTL 636
T P ++ G+ + L C A P + W + +R + ++ TL
Sbjct: 4133 TLPGDRSL-----RLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQD-----GGSTL 4182
Query: 637 SIPKVQVSDSGYYRCVAVNQQG 658
V DSG Y C A N+ G
Sbjct: 4183 QRAAVSREDSGTYVCWAENRVG 4204
Score = 60.8 bits (146), Expect = 2e-08
Identities = 48/201 (23%), Positives = 80/201 (39%), Gaps = 17/201 (8%)
Query: 461 QTISTKDTRQARGRSWVMIEPSGAVQ---RDQTVLEGGPCQLSCNVKASESPSIFWVLPD 517
Q +++ R W+++ + V Q +G ++SC+ +P I W
Sbjct: 586 QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 645
Query: 518 GSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPST 577
++ + DS+ + + G L I+ + P D+G Y C A D+ + P +
Sbjct: 646 QALQE------DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 699
Query: 578 QPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLS 637
A V + GE L C A +P + W +I +S +G L
Sbjct: 700 VSAVNAVVLVAV--GEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS------SGKLR 751
Query: 638 IPKVQVSDSGYYRCVAVNQQG 658
IP Q D+G Y C AVN+ G
Sbjct: 752 IPAAQERDAGTYTCRAVNELG 772
Score = 60.8 bits (146), Expect = 2e-08
Identities = 49/198 (24%), Positives = 80/198 (40%), Gaps = 26/198 (13%)
Query: 476 WVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDP---DSKF 532
W E SG ++R + G L C + + P + W K P +P
Sbjct: 1207 WGADETSGLLER----VAGENASLPCPARGTPKPQVTW-------RKGPSSEPLHGQPGV 1255
Query: 533 SILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPG 592
++L G L + S+ P+DSG Y+C A +++V P + + + G
Sbjct: 1256 AVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAG 1315
Query: 593 ESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNG------------TLSIPK 640
+S+TL C+A P + W+ + + L + + L G +L P+
Sbjct: 1316 QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPR 1375
Query: 641 VQVSDSGYYRCVAVNQQG 658
+Q DSG Y C A NQ G
Sbjct: 1376 IQEGDSGLYSCRAENQAG 1393
Score = 60.5 bits (145), Expect = 2e-08
Identities = 46/175 (26%), Positives = 72/175 (41%), Gaps = 14/175 (8%)
Query: 496 PCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSDSGLYQ 554
P L C P+I W + + P +L+ GW L++ + DSGLY
Sbjct: 2369 PLTLLCEAMGIPPPAIRWFRGEEPV------SPGEDTYLLAGGWMLKMTQTQEQDSGLYS 2422
Query: 555 CIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILP 614
C+A R + V V P + E I G++ L CN P+ L+W
Sbjct: 2423 CLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 2482
Query: 615 NRRIINDLANTSHVYMLPNGT-LSIPKVQVSDSGYYRCVAVNQQG--ADHFTVGI 666
R LA ++ P+G L + + +S +G+Y C+A N G HF + +
Sbjct: 2483 GR----PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSV 2533
Score = 60.1 bits (144), Expect = 3e-08
Identities = 52/182 (28%), Positives = 72/182 (39%), Gaps = 14/182 (7%)
Query: 491 VLEGGPCQLSCNVKASES-PSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
VLEG P L C V A P W L DG L P S+ SI + G L +
Sbjct: 896 VLEGQPVSLPCIVLAGRPLPERHW-LKDGRPLP-----PGSRHSIRADGSLHLDRALQEH 949
Query: 550 SGLYQCIA-QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAH 608
+G Y C+A R V V+ P P +T N G +LPC A +P
Sbjct: 950 AGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHIT---NEGVPASLPCVASGVPAPT 1006
Query: 609 LSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
++W + + H + GTL I + D+G Y C A N G + ++V
Sbjct: 1007 ITWTKETNALTS---RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063
Query: 669 TK 670
+
Sbjct: 1064 NR 1065
Score = 58.9 bits (141), Expect = 7e-08
Identities = 52/185 (28%), Positives = 80/185 (43%), Gaps = 19/185 (10%)
Query: 484 AVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIK 543
+ + TV P L C A SP+I W + DG AP + + + + L+I
Sbjct: 2546 SADEEVTVTVNNPISLICEALAFPSPNITW-MKDG----APFEASRNIQLLPGTHGLQIL 2600
Query: 544 SMEPSDSGLYQCIAQVRDEMDRMV--YRVLVQSPSTQPAEKDTVTIGKNP-----GESVT 596
+ + D+G Y C+ V +E+ V Y V V P + + +G ++T
Sbjct: 2601 NAQKEDAGQYTCV--VTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLT 2658
Query: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTL-SIPKVQVSDSGYYRCVAVN 655
L C + A+P + W + + +S + +L G L I QVSDSG Y CVA N
Sbjct: 2659 LECESWAVPPPTIRWYKDGQPV----TPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714
Query: 656 QQGAD 660
G D
Sbjct: 2715 VAGED 2719
Score = 58.5 bits (140), Expect = 9e-08
Identities = 46/175 (26%), Positives = 72/175 (41%), Gaps = 13/175 (7%)
Query: 486 QRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSM 545
Q D TV P L+C+ +P++ W S A + S + + SG L I
Sbjct: 3863 QTDFTVTMMAPVVLTCHSTGIPAPTVSW-----SKAGAQLGARGSGYRVSPSGALEIGQA 3917
Query: 546 EPSDSGLYQCIAQVRDEM-DRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
P +G Y C A+ + + V+ + SP +P + + E V LPC A I
Sbjct: 3918 LPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAE---EEVLLPCEASGI 3974
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
P ++W + ++ +LP G L I D+G Y C+A N G+
Sbjct: 3975 PRPTITWQKEGLNVATGVSTQ----VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 4025
Score = 57.8 bits (138), Expect = 2e-07
Identities = 62/233 (26%), Positives = 97/233 (41%), Gaps = 16/233 (6%)
Query: 439 IQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTV--LEGGP 496
+QL R QS+ V Y + S + + + R +V GA R V + G P
Sbjct: 1558 LQLGRAQSSDAGV---YTCKASNAVGAAE-KATRLDVYVPPTIEGAGGRPYVVKAVAGRP 1613
Query: 497 CQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCI 556
L C + SP++ W + ++ ++ S+L R++S + SGLY C+
Sbjct: 1614 VALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVL-----RLESPGEASSGLYSCV 1668
Query: 557 AQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNR 616
A + Y V VQ P + + G+ + LPC A P + W L N
Sbjct: 1669 ASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW-LQNG 1727
Query: 617 RIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
R +LA V + G TL I V++ SG + C A N+ G V ++V
Sbjct: 1728 RPAEELAG---VQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSV 1777
Score = 57.0 bits (136), Expect = 3e-07
Identities = 43/169 (25%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
VL G L+C + + P + W DG +L+ G + ++ SD+
Sbjct: 1131 VLVGEALDLNCVAEGNPEPQLSWS-KDGVVLQGRGPQ----------GSVHFAAIRTSDA 1179
Query: 551 GLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLS 610
G Y+C A +D + V P A++ + + + GE+ +LPC A P+ ++
Sbjct: 1180 GRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVT 1239
Query: 611 WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
W L V +L G+L + V +DSG Y C A N+ G+
Sbjct: 1240 W--RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 1286
Score = 57.0 bits (136), Expect = 3e-07
Identities = 47/189 (24%), Positives = 78/189 (41%), Gaps = 16/189 (8%)
Query: 481 PSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWL 540
P+ V +QT L L C +P + W + P+D +F IL G L
Sbjct: 3680 PAVNVSVNQTAL------LPCQADGVPAPLVSWRKD-----RVPLDPRSPRFEILPEGSL 3728
Query: 541 RIKSMEPSDSGLYQCIAQVRDEMDRMVYRV-LVQSPSTQPAEKDTVTIGKNPGESVTLPC 599
RI+ + D+G Y C+A DR + +++ P+ P+ + P LPC
Sbjct: 3729 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTP---ALLPC 3785
Query: 600 NALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
A P+ + W +++ L ++ +LP+ L + DS + CV N+ G
Sbjct: 3786 EASGSPKPLVVWWKDGQKLDFRLQQGAY-RLLPSNALLLTAPGPQDSAQFECVVSNEVGE 3844
Query: 660 DHFTVGITV 668
H +TV
Sbjct: 3845 AHRLYQVTV 3853
Score = 56.6 bits (135), Expect = 3e-07
Identities = 51/186 (27%), Positives = 76/186 (40%), Gaps = 10/186 (5%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMD-DPDSKFSILSSGWLRIKSM 545
RD TV G L+C P++ W DG L + S+ SG L +S+
Sbjct: 793 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESV 852
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALA-- 603
P D Y C A+ + R++V + T+ G+ V+LPC LA
Sbjct: 853 APEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGR 912
Query: 604 -IPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHF 662
+PE H W+ R L S + +G+L + + +G Y CVA N G+ H
Sbjct: 913 PLPERH--WLKDGR----PLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHR 966
Query: 663 TVGITV 668
V + V
Sbjct: 967 DVELVV 972
Score = 56.6 bits (135), Expect = 3e-07
Identities = 44/162 (27%), Positives = 70/162 (43%), Gaps = 18/162 (11%)
Query: 508 SPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIA-QVRDEMDRM 566
SP W P G + + P L+I+ ++ D G+Y C A + E R
Sbjct: 1829 SPGSLWGEPTGIPVAYSLPPP-----------LQIEKVDLRDEGIYTCAATNLAGESKRE 1877
Query: 567 VYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTS 626
V ++ P+ +P + + SVTL C A +P +SW ++ + + + T
Sbjct: 1878 VALKVLVPPNIEPGPVNKAVL---ENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTV 1934
Query: 627 HVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
V L I + Q+SD+G YRCVA N G+ G+ V
Sbjct: 1935 SV---DGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV 1973
Score = 55.8 bits (133), Expect = 6e-07
Identities = 38/133 (28%), Positives = 64/133 (48%), Gaps = 6/133 (4%)
Query: 536 SSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESV 595
+S W +++ + ++ G Y+C A R R +++V P Q VT+ +PGE+
Sbjct: 478 NSSWEILRASK-AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV--SPGETA 534
Query: 596 TLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVN 655
L C L +L+W+ R + A+T V L + +L I + +D G Y+CVA N
Sbjct: 535 VLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 591
Query: 656 QQGADHFTVGITV 668
G +V + V
Sbjct: 592 ANGVTRASVWLLV 604
Score = 55.8 bits (133), Expect = 6e-07
Identities = 50/199 (25%), Positives = 78/199 (39%), Gaps = 10/199 (5%)
Query: 472 RGRSWVMIEPSGAVQRDQ--TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPD 529
+GR ++EP T+ P L C S P + W DG L +
Sbjct: 3754 QGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVW-WKDGQKLDFRLQQ-- 3810
Query: 530 SKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGK 589
+ +L S L + + P DS ++C+ +Y+V V P T ++ T+
Sbjct: 3811 GAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTM 3870
Query: 590 NPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYY 649
V L C++ IP +SW ++ A S + P+G L I + +G Y
Sbjct: 3871 MA--PVVLTCHSTGIPAPTVSWSKAGAQLG---ARGSGYRVSPSGALEIGQALPIHAGRY 3925
Query: 650 RCVAVNQQGADHFTVGITV 668
C A N G H V +TV
Sbjct: 3926 TCSARNSAGVAHKHVFLTV 3944
Score = 55.5 bits (132), Expect = 8e-07
Identities = 45/174 (25%), Positives = 65/174 (37%), Gaps = 19/174 (10%)
Query: 492 LEGGPCQLSCNVKASESPSIFW------VLPDGSILKAPMDDPDSKFSILSSGWLRIKSM 545
L G +L C +P + W VLP G L+ D LRI
Sbjct: 1421 LAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV----------LRITGS 1470
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP 605
D G YQC+A +++ V +P T +T + V L C A +P
Sbjct: 1471 HVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP 1530
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
+++W + +T VY L + + Q SD+G Y C A N GA
Sbjct: 1531 TPNITWFKDGALLPT---STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA 1581
Score = 55.1 bits (131), Expect = 1e-06
Identities = 44/145 (30%), Positives = 63/145 (43%), Gaps = 25/145 (17%)
Query: 531 KFSILSSGWLRIKSMEPSDSGLYQCIAQ--VRDEMDRMVYRVLVQSPSTQPAEKDTVTIG 588
++ +L SG LR+ ++ DSG Y+C A R V V V P QP + +
Sbjct: 1075 EYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVP-PQVQPGPRVLKVL- 1132
Query: 589 KNPGESVTLPCNALAIPEAHLSW-----ILPNRRIINDLANTSHVYMLPNGTLSIPKVQV 643
GE++ L C A PE LSW +L R P G++ ++
Sbjct: 1133 --VGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG--------------PQGSVHFAAIRT 1176
Query: 644 SDSGYYRCVAVNQQGADHFTVGITV 668
SD+G YRC A N G D + V + V
Sbjct: 1177 SDAGRYRCEASNSAGVDAWEVELRV 1201
Score = 55.1 bits (131), Expect = 1e-06
Identities = 37/174 (21%), Positives = 70/174 (40%), Gaps = 19/174 (10%)
Query: 486 QRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSM 545
Q D V+ G +L C + P + W+ +L ++ S L+++++
Sbjct: 3413 QNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPS---------LQLEAV 3463
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP 605
DSG Y C+A R +++ V P + PG + L C+A P
Sbjct: 3464 GAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTP 3523
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
+ +++W + + L N + + ++V D+G Y C+A + GA
Sbjct: 3524 QPNITWHKDGQALTR----------LENNSRATRVLRVRDAGLYTCLAESPAGA 3567
Score = 54.7 bits (130), Expect = 1e-06
Identities = 49/184 (26%), Positives = 71/184 (38%), Gaps = 13/184 (7%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
++ VLE L C P + W P+ + LRI+ +
Sbjct: 1894 NKAVLENASVTLECLASGVPPPDVSWFKGH-----QPVSSWMGVTVSVDGRVLRIEQAQL 1948
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLVQSPS--TQPAEKDTVTIGKNPGESVTLPCNALAIP 605
SD+G Y+C+A + Y + V P T P + P V L CNA P
Sbjct: 1949 SDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP---VRLTCNATGAP 2005
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
L W+ + A T + + P G L++ + SDSG Y CVAV+ G D V
Sbjct: 2006 SPTLMWLKDGNPV--SPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV 2063
Query: 665 GITV 668
+ V
Sbjct: 2064 VLQV 2067
Score = 54.7 bits (130), Expect = 1e-06
Identities = 50/190 (26%), Positives = 73/190 (38%), Gaps = 26/190 (13%)
Query: 534 ILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGE 593
+L G LRI P D+G Y CIA+ R++VQ P E + G
Sbjct: 3996 VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPV--IENGLPDLSTTEGS 4053
Query: 594 SVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
LPC A PE +++W + + + + P+G L + ++ D+G Y C A
Sbjct: 4054 HAFLPCKARGSPEPNITWDKDGQPVSGAEGKFT---IQPSGELLVKNLEGQDAGTYTCTA 4110
Query: 654 VNQQGADHFTVGIT--VTKKGSGLPSKRGRRPGAKALSR-------------------VR 692
N G V +T V + LP R R G + R V
Sbjct: 4111 ENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVT 4170
Query: 693 EDIVEDEGGS 702
E + E +GGS
Sbjct: 4171 EGVSEQDGGS 4180
Score = 51.2 bits (121), Expect = 1e-05
Identities = 47/176 (26%), Positives = 73/176 (41%), Gaps = 21/176 (11%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
VL+G L CNV P + W DG P+ D+ L++ S +
Sbjct: 2457 VLDGQTAHLMCNVTGHPQPKLTW-FKDG----RPLARGDAHHISPDGVLLQVLQANLSSA 2511
Query: 551 GLYQCIA--QVRDEMDRMVYRVL----VQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
G Y CIA V ++ VL + + A+++ NP ++L C ALA
Sbjct: 2512 GHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP---ISLICEALAF 2568
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGT--LSIPKVQVSDSGYYRCVAVNQQG 658
P +++W+ + ++ +LP GT L I Q D+G Y CV N+ G
Sbjct: 2569 PSPNITWMKDGA----PFEASRNIQLLP-GTHGLQILNAQKEDAGQYTCVVTNELG 2619
Score = 50.8 bits (120), Expect = 2e-05
Identities = 45/175 (25%), Positives = 75/175 (42%), Gaps = 20/175 (11%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
D+++ G L C + S +P I W + D + + + L+ ++
Sbjct: 4137 DRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQD-------GGSTLQRAAVSR 4189
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
DSG Y C A+ R + V V V+ E + + + G S+ L C P
Sbjct: 4190 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLV-EPVGGSIQLDCVVRGDPVP 4248
Query: 608 HLSWI---LPNRRIINDLANTSHV-YMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ WI LP R SH+ + L NG+L+I + + D+G Y+C+A N+ G
Sbjct: 4249 DIHWIKDGLPLRG--------SHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMG 4295
Score = 50.1 bits (118), Expect = 3e-05
Identities = 54/185 (29%), Positives = 75/185 (40%), Gaps = 36/185 (19%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG-WLRIKSMEPSDSGLYQCIA 557
L C A P+I W DG + P S+ +L G L+I+ + SDSG Y C+A
Sbjct: 2659 LECESWAVPPPTIRWY-KDGQPVT-----PSSRLQVLGEGRLLQIQPTQVSDSGRYLCVA 2712
Query: 558 QVRDEMDRMVYRVLVQSP----------------STQPAEKDTVT-----IGKNPGESVT 596
D + VL+Q P S + + VT + NP
Sbjct: 2713 TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNP---AY 2769
Query: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVN 655
L C+ AIP L+W R L+ V +L G L IP V+ ++G Y C A N
Sbjct: 2770 LYCDTNAIPPPDLTWY----REDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASN 2825
Query: 656 QQGAD 660
+ G D
Sbjct: 2826 EVGED 2830
Score = 49.7 bits (117), Expect = 4e-05
Identities = 56/204 (27%), Positives = 84/204 (41%), Gaps = 23/204 (11%)
Query: 479 IEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG 538
IE SG + ++ G P +L C+ + + P+I W DG L L +
Sbjct: 3496 IEDSGQ-PTELSLTPGAPMELLCDAQGTPQPNITWH-KDGQALTR-----------LENN 3542
Query: 539 WLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEK-DTVTIGKNPGESVTL 597
+ + D+GLY C+A+ +RV VQ+P + +G PG+ V L
Sbjct: 3543 SRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-L 3601
Query: 598 PCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGT-LSIPKVQVSDSGYYRCVAVNQ 656
C+ A P ++W R L +H G L + + +DSG Y C A N
Sbjct: 3602 ECSVEAEPAPKITW----HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 3657
Query: 657 QGADH--FTVGI-TVTKKGSGLPS 677
G+ F V I TV SG P+
Sbjct: 3658 AGSTSVAFRVEIHTVPTIRSGPPA 3681
Score = 48.5 bits (114), Expect = 9e-05
Identities = 44/183 (24%), Positives = 73/183 (39%), Gaps = 14/183 (7%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
T + L C+V A +P + W ++ + F + + L++ SD
Sbjct: 2948 TAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG-----EEVFLLPGTHTLQLGRARLSD 3002
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQSP----STQPAEKDTVTIGKNPGESVTLPCNALAIP 605
SG+Y C A D+ + ++ V P +D V + G+ L C A+P
Sbjct: 3003 SGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLV--RVGDKAVLSCETDALP 3060
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVG 665
E ++W + ++ LA + + L I + QVSD G Y C N G T
Sbjct: 3061 EPTVTWYKDGQPLV--LAQRTQA-LRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT 3117
Query: 666 ITV 668
+TV
Sbjct: 3118 LTV 3120
Score = 43.9 bits (102), Expect = 0.002
Identities = 41/182 (22%), Positives = 67/182 (36%), Gaps = 22/182 (12%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW------------ 539
+ G L C+ P I W L D ++ P+ + + GW
Sbjct: 1313 MAGQSLTLECDANGFPVPEIVW-LKDAQLVGVPLGWAGYGWDL---GWGQVGGHRLLDEG 1368
Query: 540 --LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTL 597
L ++ DSGLY C A+ + + + +LV +P + + G V L
Sbjct: 1369 QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVEL 1428
Query: 598 PCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNG-TLSIPKVQVSDSGYYRCVAVNQ 656
C +P + W + + L H+ + +G L I V D G Y+CVA +
Sbjct: 1429 QCWTSGVPTPQVEWTKDRQPV---LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP 1485
Query: 657 QG 658
G
Sbjct: 1486 AG 1487
Score = 38.9 bits (89), Expect = 0.073
Identities = 45/173 (26%), Positives = 65/173 (37%), Gaps = 13/173 (7%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
TV EG P LSC + P I W DG L P + + L + + +
Sbjct: 2173 TVREGHPTSLSCECRGVPFPKISW-RKDGQPL--PGEGAGLQHVSAVGRLLYLGQAQLAQ 2229
Query: 550 SGLY--QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
G Y +C V + + V V P E T G + TL CNA P
Sbjct: 2230 EGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA-TLECNATGKPPP 2288
Query: 608 HLSWILPNRRIINDLANTSHVYMLPN--GTLSIPKVQVSDSGYYRCVAVNQQG 658
++W + + +L L N +L + + Q + +G Y CVA N G
Sbjct: 2289 TVTWERDGQPVGAELG-----LQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 2336
Score = 36.6 bits (83), Expect = 0.36
Identities = 22/71 (30%), Positives = 33/71 (46%), Gaps = 6/71 (8%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
+D TV G L C +P+I W L G L+A + L G L ++++E
Sbjct: 4316 QDMTVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRA-----SRRLRTLPDGSLWLENVE 4369
Query: 547 PSDSGLYQCIA 557
D+G Y C+A
Sbjct: 4370 TGDAGTYDCVA 4380
Score = 33.9 bits (76), Expect = 2.3
Identities = 34/160 (21%), Positives = 58/160 (36%), Gaps = 7/160 (4%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ 558
L C A P + W DG P++ L++ + D+G Y C A
Sbjct: 2090 LECQSHAMPPPVLSW-WKDGR----PLEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 2144
Query: 559 VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRI 618
+ Y + V P +++ T+ G +L C +P +SW + +
Sbjct: 2145 NQAGHSEKHYNLNVWVAPVFPL-RESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL 2203
Query: 619 INDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ A HV + L + + Q++ G Y C N G
Sbjct: 2204 PGEGAGLQHVSAV-GRLLYLGQAQLAQEGTYTCECSNVVG 2242
Score = 32.7 bits (73), Expect = 5.2
Identities = 41/184 (22%), Positives = 68/184 (36%), Gaps = 19/184 (10%)
Query: 859 SSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITSTEGDLKGTAAPTLI---- 914
+S +G + H ++++ P V EE+V++++ S + G PT+
Sbjct: 2823 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 2882
Query: 915 SEPYEPSPTLHTLD--TVYEKPTHEETATEGWSAADVGSSPEPTSSEYEPPLDAVSLAES 972
P+ PSP L L+ V + T E AD S ++ +L
Sbjct: 2883 GLPFSPSPRLQVLEDGQVLQVSTAE--------VADAASYMCVAENQAGSAEKLFTLRVQ 2934
Query: 973 EPMQYFDPDLETKSQPDEDKMKEDTFAHLTPTPTI-WVNDSSTSQLFEDSTIGEPGVPGQ 1031
P + DLE + + H P P + W DS L E+ + +PG
Sbjct: 2935 VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFL----LPGT 2990
Query: 1032 SHLQ 1035
LQ
Sbjct: 2991 HTLQ 2994
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 245 bits (625), Expect = 5e-64
Identities = 208/733 (28%), Positives = 320/733 (43%), Gaps = 64/733 (8%)
Query: 1903 QRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTV 1962
+ F+ N + I + + G Y CTA + G R + VT PQ++ + +VTV
Sbjct: 354 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA--PNVTV 411
Query: 1963 YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGV 2022
G+T + C G ++W+ R W+ + GR+ + +L I +D G
Sbjct: 412 SPGETAVLSCRVLGEAPYNLTWV----RDWRVLPASTGRVAQLADLSLEISGIIPTDGGR 467
Query: 2023 YKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWV 2082
Y+CVASNA G ++ L V P V ++ S G+ + + C+A P P + W
Sbjct: 468 YQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISW- 524
Query: 2083 LGDGTQIRPSQFLH--GNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ 2140
R SQ L + V GTL I+ +AP+D+G Y C A N VG+ + TV L
Sbjct: 525 ------SRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT 578
Query: 2141 RAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV 2200
+ + + V G L C ASG P PR++W MI A S
Sbjct: 579 DPPSVSAVNAV----VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS---- 630
Query: 2201 FANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGD 2260
G L + + ++DAG Y C A N++GD +++ V P E D V G
Sbjct: 631 ---GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTE--LPRDVTVELGRS 685
Query: 2261 LKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEG 2320
+ C ATG P P ++W DG + + GR R ++G L+F V ++
Sbjct: 686 ALLACRATGRPPPTVTWRRGDGQPLGLRL----GAGRGSRSRQPDSGVLFFESVAPEDQA 741
Query: 2321 DYTCFAENQVGKDEMRVRVKVV-TAPATIRNKTYLAVQVPYGDVVTVAC-EAKGEPMPKV 2378
Y C A N GK + R+ V AP I + V+V G V++ C G P+P+
Sbjct: 742 PYVCEARNVFGKVQAEARLIVTGHAPPQIASSA-PTVRVLEGQPVSLPCIVLAGRPLPER 800
Query: 2379 TWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQ 2438
WL + P S ++ I DG+L + +A + +G Y+C+ N+AG + V + V V
Sbjct: 801 HWLKDGRPLPPGS--RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV- 857
Query: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLP-APYYGNRITV 2497
PP+I+ T I G + C A G+P P + W + P+Y V
Sbjct: 858 PPRIHP-----TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY----NV 908
Query: 2498 HGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH------DPISEK 2551
G+L I D+ VC A N G + ++L+V KP H + +
Sbjct: 909 SKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV---NTKPRIHMNGSRNANVPLQ 965
Query: 2552 ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQL-QRFYHKADGMLHISGLSSVD 2610
+TA AG ++L+C A G+P P + W D + + R+ G L ++ + D
Sbjct: 966 VTAKAGEEVTLDCEAKGSPPPLVTWT----KDSRPVPPITNRYGLLPSGSLRLAQVQVGD 1021
Query: 2611 AGAYRCVARNAAG 2623
+G Y C A N AG
Sbjct: 1022 SGHYECTASNPAG 1034
Score = 209 bits (532), Expect = 3e-53
Identities = 209/731 (28%), Positives = 287/731 (39%), Gaps = 68/731 (9%)
Query: 2104 NGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGT 2163
N + I + + G YEC A + G+ R Q+ V +P T V G T
Sbjct: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV---PAPNVT-VSPGET 416
Query: 2164 LKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVA 2223
L C G+ + W R L + R+ A+ +L + + D G Y CVA
Sbjct: 417 AVLSCRVLGEAPYNLTW----VRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVA 472
Query: 2224 RNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGS 2283
N G + + V P H G ++KV C A+G P P ISWS +
Sbjct: 473 SNANGVTRASVWLLVREAPQVSIHTSSQHFS--QGVEVKVSCSASGYPTPHISWSRESQA 530
Query: 2284 LVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVT 2343
L +DS R V GTL V + G+Y+C A N+VG D+ V +
Sbjct: 531 L------QEDS-----RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD 579
Query: 2344 APATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVI--PTSSEKYQIYQDG 2401
P+ + V V G+ + CEA G P P+V W ++I P S G
Sbjct: 580 PPSV--SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS------G 631
Query: 2402 TLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSR 2461
L I AQ D+G YTC N G+ + + V P++ P +T G
Sbjct: 632 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVG-HAPQLTELPRDVTVEL-----GRS 685
Query: 2462 KLIDCKAEGIPTPRVLWAFPEGVVLPAPY---YGNRITVHGNGSLDIRSLRKSDSVQLVC 2518
L+ C+A G P P V W +G L G+R +G L S+ D VC
Sbjct: 686 ALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVC 745
Query: 2519 MARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSA-AGTPTPSLVWV 2577
ARN G+ + +L V I + + + G +SL C AG P P W
Sbjct: 746 EARNVFGKVQAEARLIVTGHAPPQIASS--APTVRVLEGQPVSLPCIVLAGRPLPERHW- 802
Query: 2578 LPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP 2637
L +G L G R +ADG LH+ AG Y CVA N AG R V L V + P
Sbjct: 803 LKDGRPLPPGS---RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPP 859
Query: 2638 EANKQY-HNLVSIINGETLKLPCTPPGAGQGRFSWTLP-NGMHLEGPQTLGRVSLLDNGT 2695
+ H++ + G LPC G +WT N + GP ++ GT
Sbjct: 860 RIHPTATHHITN--EGVPASLPCVASGVPAPTITWTKETNALTSRGPH----YNVSKEGT 913
Query: 2696 LTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYP------PRITSEPTPVIYTRPGN 2749
L + + S D G YVC G S + + V P R + P V + G
Sbjct: 914 LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVT-AKAGE 972
Query: 2750 TVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYK 2809
V L+C A G P +TW K YG L P GSL + D+G Y+
Sbjct: 973 EVTLDCEAKGSPPPLVTWT---KDSRPVPPITNRYG---LLPSGSLRLAQVQVGDSGHYE 1026
Query: 2810 CMAKNILGSDS 2820
C A N GS S
Sbjct: 1027 CTASNPAGSAS 1037
Score = 206 bits (523), Expect = 3e-52
Identities = 178/616 (28%), Positives = 269/616 (43%), Gaps = 47/616 (7%)
Query: 1819 ITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQI-LTKSPQTVSVTAETDTVFPCEA 1877
I+ + + G +Q + G AS + + E PQ+ + S Q S E C A
Sbjct: 457 ISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKV--SCSA 514
Query: 1878 TGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLD 1937
+G P P ++W++ S AL + R V GTL+I+ V +D G Y C A+N G D
Sbjct: 515 SGYPTPHISWSRESQ-ALQEDS----RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTD 569
Query: 1938 RMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSP 1997
+ V L T P +++ V V +G+ + C A G P P++ W R + +
Sbjct: 570 QETVTLYYT--DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY---RGGLEMILA 624
Query: 1998 VEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENI 2057
EG + L I A D G Y C A N G S I+L V P + E ++
Sbjct: 625 PEG----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQL--TELPRDV 678
Query: 2058 SLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQ--IRPSQFLHGNLFVFPNGTLYIRNLAPK 2115
++ G S + C A P P+V W GDG +R +G L+ ++AP+
Sbjct: 679 TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPE 738
Query: 2116 DSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSA-SGDP 2174
D Y C A N+ G + +L + A +I ++P V G + L C +G P
Sbjct: 739 DQAPYVCEARNVFGKVQAEARL-IVTGHAPPQIASSAP-TVRVLEGQPVSLPCIVLAGRP 796
Query: 2175 WPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVL 2234
P W + + SR + A+G+L + + AG Y CVA N G + +
Sbjct: 797 LPERHWLKDGRPLPPG-----SRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV 851
Query: 2235 KVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDS 2294
++ VV P +I H H G + CVA+G+P P I+W+ +L +
Sbjct: 852 EL-VVQVPPRI-HPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTS-------- 901
Query: 2295 GGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRN---- 2350
R Y V GTL + ++ G Y C A N VG +R+ V T P N
Sbjct: 902 --RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRN 959
Query: 2351 -KTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQ 2409
L V G+ VT+ CEAKG P P VTW + ++ +P + +Y + G+L + + Q
Sbjct: 960 ANVPLQVTAKAGEEVTLDCEAKGSPPPLVTW-TKDSRPVPPITNRYGLLPSGSLRLAQVQ 1018
Query: 2410 RSDSGNYTCLVRNSAG 2425
DSG+Y C N AG
Sbjct: 1019 VGDSGHYECTASNPAG 1034
Score = 204 bits (518), Expect = 1e-51
Identities = 193/723 (26%), Positives = 292/723 (40%), Gaps = 60/723 (8%)
Query: 2007 NRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIH 2066
N + I AS ++ G Y+C A + AG ++ V PP + N+++ PG +
Sbjct: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL--VPAPNVTVSPGETAV 418
Query: 2067 IHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAAN 2126
+ C ++ WV ++ P+ G + + +L I + P D GRY+CVA+N
Sbjct: 419 LSCRVLGEAPYNLTWVRD--WRVLPAST--GRVAQLADLSLEISGIIPTDGGRYQCVASN 474
Query: 2127 LVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKR 2186
G R +V L V+ A + T + G +K+ CSASG P P I W S+
Sbjct: 475 ANGVTRASVWLLVREAPQVSIHTSSQ----HFSQGVEVKVSCSASGYPTPHISWSRESQA 530
Query: 2187 MIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIE 2246
+ + DSRI V A GTL+++ V +DAG+Y C A N+VG D + + P+
Sbjct: 531 LQE-----DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS--V 583
Query: 2247 HKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN 2306
V G + + C A+G+P P + W G L S G+
Sbjct: 584 SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY--RGGLEMILAPEGSSSGK--------- 632
Query: 2307 GTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTV 2366
L R+ G YTC A N++G +++ V AP + V++ G +
Sbjct: 633 --LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL--GRSALL 688
Query: 2367 ACEAKGEPMPKVTWLSPTNKVI-----PTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVR 2421
AC A G P P VTW + + + + G L + D Y C R
Sbjct: 689 ACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEAR 748
Query: 2422 NSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFP 2481
N G+ + + V P + P V E G L G P P W
Sbjct: 749 NVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE---GQPVSLPCIVLAGRPLPERHW-LK 804
Query: 2482 EGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEK 2541
+G LP G+R ++ +GSL + + + + C+A N G ++L V P
Sbjct: 805 DGRPLPP---GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVP--- 858
Query: 2542 PIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGML 2601
P H + IT G SL C A+G P P++ W G + +G L
Sbjct: 859 PRIHPTATHHIT-NEGVPASLPCVASGVPAPTITWTKETNALTSRG---PHYNVSKEGTL 914
Query: 2602 HISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP------EANKQYHNLVSIINGETL 2655
I+ S+ DAGAY C A N G + + + L V KP N V+ GE +
Sbjct: 915 LIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEV 974
Query: 2656 KLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMET 2715
L C G+ +WT + P R LL +G+L + + V D G Y C
Sbjct: 975 TLDCEAKGSPPPLVTWTKDS---RPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASN 1031
Query: 2716 EYG 2718
G
Sbjct: 1032 PAG 1034
Score = 152 bits (383), Expect = 6e-36
Identities = 131/530 (24%), Positives = 208/530 (39%), Gaps = 35/530 (6%)
Query: 2296 GRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA 2355
G + + N + EEG Y C A ++ G + ++ V P + +
Sbjct: 351 GEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVT 410
Query: 2356 VQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
V G+ ++C GE +TW+ +V+P S+ + D +L I +D G
Sbjct: 411 VSP--GETAVLSCRVLGEAPYNLTWVRDW-RVLPASTGRVAQLADLSLEISGIIPTDGGR 467
Query: 2416 YTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPR 2475
Y C+ N+ G R +VW+ V + P+++ I T + + G + C A G PTP
Sbjct: 468 YQCVASNANGVTRASVWLLVR-EAPQVS-----IHTSSQHFSQGVEVKVSCSASGYPTPH 521
Query: 2476 VLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535
+ W+ A +RI V G+L I+ + D+ C A NE G + + L
Sbjct: 522 ISWSRES----QALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY 577
Query: 2536 LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYH 2595
+P ++ + G L C A+G P P ++W G ++ +
Sbjct: 578 TDPPSV----SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR-GGLEMILAPE-----G 627
Query: 2596 KADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETL 2655
+ G L I DAG Y C A N G + L VG P+ + + V++ G +
Sbjct: 628 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD-VTVELGRSA 686
Query: 2656 KLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLL---DNGTLTVREASVFDRGTYVCR 2712
L C G +W +G L GR S D+G L + D+ YVC
Sbjct: 687 LLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 746
Query: 2713 METEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAM-GIPKADITWELPD 2771
+G +IV + P + P + G V L C+ + G P LP+
Sbjct: 747 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRP-------LPE 799
Query: 2772 KSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSK 2821
+ LK G + GSL + A Q AG Y C+A N GS +
Sbjct: 800 RHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHR 849
Score = 150 bits (378), Expect = 2e-35
Identities = 142/516 (27%), Positives = 214/516 (41%), Gaps = 43/516 (8%)
Query: 2320 GDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVT 2379
G Y C A N G V + V AP + + + G V V+C A G P P ++
Sbjct: 466 GRYQCVASNANGVTRASVWLLVREAPQVSIHTS--SQHFSQGVEVKVSCSASGYPTPHIS 523
Query: 2380 WLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP 2439
W + + S + + GTL+IQ D+GNY+C N G D++TV ++ P
Sbjct: 524 WSRESQALQEDS--RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYT-DP 580
Query: 2440 PKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHG 2499
P ++ + V +A G L+ C+A G+P PRV+W ++ AP +
Sbjct: 581 PSVSA----VNAVVLVAVGEEAVLV-CEASGVPPPRVIWYRGGLEMILAPEGSS------ 629
Query: 2500 NGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHT 2559
+G L I + ++ D+ C A NE G+A +QL V + + +T G +
Sbjct: 630 SGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT----ELPRDVTVELGRS 685
Query: 2560 ISLNCSAAGTPTPSLVWVL----PNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYR 2615
L C A G P P++ W P G L +G+ R G+L ++ D Y
Sbjct: 686 ALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRG-SRSRQPDSGVLFFESVAPEDQAPYV 744
Query: 2616 CVARNAAGHTERLVSLKV-GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLP 2674
C ARN G + L V G P V ++ G+ + LPC GR LP
Sbjct: 745 CEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLA---GR---PLP 798
Query: 2675 NGMHLEGPQTL---GRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAY 2731
L+ + L R S+ +G+L + A G Y C G + +V+
Sbjct: 799 ERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVE-LVVQV 857
Query: 2732 PPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHP 2791
PPRI T I T G L C+A G+P ITW + G +
Sbjct: 858 PPRIHPTATHHI-TNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNV------SK 910
Query: 2792 QGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+G+L I + +DAG Y C A N +G S+ + V
Sbjct: 911 EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
Score = 146 bits (368), Expect = 3e-34
Identities = 137/482 (28%), Positives = 197/482 (40%), Gaps = 40/482 (8%)
Query: 1863 VSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQD 1922
V V + V CEA+G P P V W + ++ P E +G L I Q +D
Sbjct: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP-------EGSSSGKLRIPAAQERD 642
Query: 1923 RGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQI 1982
G Y C A N G + L+V PQ L +DVTV LG + + C A G P P +
Sbjct: 643 AGTYTCRAVNELGDASAEIQLAVG-HAPQ-LTELPRDVTVELGRSALLACRATGRPPPTV 700
Query: 1983 SWIFPDRR-VWQTVSPVEG-RITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL 2040
+W D + + + G R ++ L + + D+ Y C A N G RL
Sbjct: 701 TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 760
Query: 2041 HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAA-PLPSVRWVLGDGTQIRPSQFLHGNL 2099
V P + + G + + C A PLP W L DG + P
Sbjct: 761 IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW-LKDGRPLPPGS----RH 815
Query: 2100 FVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVR 2159
+ +G+L++ + +GRY CVA N GS R V+L VQ RI T+
Sbjct: 816 SIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQ---VPPRIHPTATHHI-TN 871
Query: 2160 YGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDY 2219
G L C ASG P P I W + +AL S V GTL++ + +DAG Y
Sbjct: 872 EGVPASLPCVASGVPAPTITWT----KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAY 927
Query: 2220 LCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFY-----GGDLKVDCVATGLPNPE 2274
+C A N VG +++ V KP + N + G ++ +DC A G P P
Sbjct: 928 VCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPL 987
Query: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
++W+ S T RY + +G+L +V + + G Y C A N G
Sbjct: 988 VTWT----------KDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
Query: 2335 MR 2336
R
Sbjct: 1038 HR 1039
Score = 105 bits (262), Expect = 6e-22
Identities = 90/295 (30%), Positives = 130/295 (44%), Gaps = 24/295 (8%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEA-TGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG 1911
PQI + +P TV V PC G+P P W K G + P +R + +G
Sbjct: 768 PQIASSAP-TVRVLEGQPVSLPCIVLAGRPLPERHWLK--DGRPLPPGSR---HSIRADG 821
Query: 1912 TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAME 1971
+L + + + G+Y C A+N G V L V V P+I + +T G ++
Sbjct: 822 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVP-PRIHPTATHHITNE-GVPASLP 879
Query: 1972 CLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAA 2031
C+A G PAP I+W + ++ + + TL I + S D G Y C A+N
Sbjct: 880 CVASGVPAPTITWT----KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 935
Query: 2032 GADSLAIRLHVAALPPVIHQEKLENISLP------PGLSIHIHCTAKAAPLPSVRWVLGD 2085
G S +RL V P IH N ++P G + + C AK +P P V W D
Sbjct: 936 GFSSQEMRLSVNTKPR-IHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTK-D 993
Query: 2086 GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ 2140
+ P +G L P+G+L + + DSG YEC A+N GSA L VQ
Sbjct: 994 SRPVPPITNRYGLL---PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQ 1045
Score = 98.6 bits (244), Expect = 8e-20
Identities = 73/222 (32%), Positives = 107/222 (48%), Gaps = 27/222 (12%)
Query: 1874 PCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNL 1933
PC A+G P P +TWTK T AL +R + V K GTL+I + QD G Y+CTA+N
Sbjct: 879 PCVASGVPAPTITWTK-ETNAL---TSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNT 934
Query: 1934 HGLDRMVVLLSVTVQQPQILASHYQD------VTVYLGDTIAMECLAKGTPAPQISWIFP 1987
G + LSV +P+I + ++ VT G+ + ++C AKG+P P ++W
Sbjct: 935 VGFSSQEMRLSVNT-KPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKD 993
Query: 1988 DRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHV----- 2042
R V P+ R L + +L + + D G Y+C ASN AG+ S L V
Sbjct: 994 SR----PVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTS 1049
Query: 2043 ---AALPPVIHQEKLENISL----PPGLSIHIHCTAKAAPLP 2077
+LP H L +S+ P S+ + + APLP
Sbjct: 1050 WQPQSLPVPHHPACLSGLSVPLLQPTPRSVRLCHLSLRAPLP 1091
Score = 66.6 bits (161), Expect = 3e-10
Identities = 65/253 (25%), Positives = 103/253 (40%), Gaps = 17/253 (6%)
Query: 2578 LPNGTDLQSGQ----QLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV 2633
LP L+ G+ + + F + I S + G Y C A + AG + V
Sbjct: 337 LPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV 396
Query: 2634 GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN 2693
P N V++ GET L C G +W + P + GRV+ L +
Sbjct: 397 TDPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLAD 452
Query: 2694 GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKL 2753
+L + D G Y C G + S+ ++V P S T + G VK+
Sbjct: 453 LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQ--VSIHTSSQHFSQGVEVKV 510
Query: 2754 NCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAK 2813
+C A G P I+W ++ + +R++ + QG+L IQ DAG Y C A
Sbjct: 511 SCSASGYPTPHISWSRESQALQE---DSRIH----VDAQGTLIIQGVAPEDAGNYSCQAT 563
Query: 2814 NILGSDSKTTYIH 2826
N +G+D +T ++
Sbjct: 564 NEVGTDQETVTLY 576
Score = 65.1 bits (157), Expect = 9e-10
Identities = 57/208 (27%), Positives = 88/208 (42%), Gaps = 12/208 (5%)
Query: 463 ISTKDTRQARGRSWVMIEPSGAVQRDQ-TVLEGGPCQLSCNVKASESPSIFWVLPDGSIL 521
+S T +A+ + V P V TV G LSC V ++ WV D +L
Sbjct: 382 VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVR-DWRVL 440
Query: 522 KAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAE 581
A + + L+ L I + P+D G YQC+A + + R +LV+
Sbjct: 441 PAST----GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIH 496
Query: 582 KDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKV 641
+ + G V + C+A P H+SW ++ + D S +++ GTL I V
Sbjct: 497 TSSQHFSQ--GVEVKVSCSASGYPTPHISWSRESQALQED----SRIHVDAQGTLIIQGV 550
Query: 642 QVSDSGYYRCVAVNQQGADHFTVGITVT 669
D+G Y C A N+ G D TV + T
Sbjct: 551 APEDAGNYSCQATNEVGTDQETVTLYYT 578
Score = 60.8 bits (146), Expect = 2e-08
Identities = 48/201 (23%), Positives = 80/201 (39%), Gaps = 17/201 (8%)
Query: 461 QTISTKDTRQARGRSWVMIEPSGAVQ---RDQTVLEGGPCQLSCNVKASESPSIFWVLPD 517
Q +++ R W+++ + V Q +G ++SC+ +P I W
Sbjct: 469 QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 528
Query: 518 GSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPST 577
++ + DS+ + + G L I+ + P D+G Y C A D+ + P +
Sbjct: 529 QALQE------DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS 582
Query: 578 QPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLS 637
A V + GE L C A +P + W +I +S +G L
Sbjct: 583 VSAVNAVVLVAV--GEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS------SGKLR 634
Query: 638 IPKVQVSDSGYYRCVAVNQQG 658
IP Q D+G Y C AVN+ G
Sbjct: 635 IPAAQERDAGTYTCRAVNELG 655
Score = 60.8 bits (146), Expect = 2e-08
Identities = 53/183 (28%), Positives = 72/183 (39%), Gaps = 14/183 (7%)
Query: 491 VLEGGPCQLSCNVKASES-PSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
VLEG P L C V A P W L DG L P S+ SI + G L +
Sbjct: 779 VLEGQPVSLPCIVLAGRPLPERHW-LKDGRPLP-----PGSRHSIRADGSLHLDRALQEH 832
Query: 550 SGLYQCIA-QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAH 608
+G Y C+A R V V+ P P +T N G +LPC A +P
Sbjct: 833 AGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHIT---NEGVPASLPCVASGVPAPT 889
Query: 609 LSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
++W + + H + GTL I + D+G Y C A N G + ++V
Sbjct: 890 ITWTKETNALTS---RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
Query: 669 TKK 671
K
Sbjct: 947 NTK 949
Score = 60.8 bits (146), Expect = 2e-08
Identities = 46/175 (26%), Positives = 71/175 (40%), Gaps = 19/175 (10%)
Query: 493 EGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGL 552
EG P L C +P+I W ++ +++ G L I D+G
Sbjct: 872 EGVPASLPCVASGVPAPTITWTKETNALTSR-----GPHYNVSKEGTLLIAQPSAQDAGA 926
Query: 553 YQCIAQVRDEMDRMVYRVLVQSPSTQPA--------EKDTVTIGKNPGESVTLPCNALAI 604
Y C A R+ V +T+P + + GE VTL C A
Sbjct: 927 YVCTATNTVGFSSQEMRLSV---NTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGS 983
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
P ++W +R + T+ +LP+G+L + +VQV DSG+Y C A N G+
Sbjct: 984 PPPLVTWTKDSRPVP---PITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGS 1035
Score = 56.6 bits (135), Expect = 3e-07
Identities = 51/186 (27%), Positives = 76/186 (40%), Gaps = 10/186 (5%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMD-DPDSKFSILSSGWLRIKSM 545
RD TV G L+C P++ W DG L + S+ SG L +S+
Sbjct: 676 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESV 735
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALA-- 603
P D Y C A+ + R++V + T+ G+ V+LPC LA
Sbjct: 736 APEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGR 795
Query: 604 -IPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHF 662
+PE H W+ R L S + +G+L + + +G Y CVA N G+ H
Sbjct: 796 PLPERH--WLKDGR----PLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHR 849
Query: 663 TVGITV 668
V + V
Sbjct: 850 DVELVV 855
Score = 55.8 bits (133), Expect = 6e-07
Identities = 38/133 (28%), Positives = 64/133 (48%), Gaps = 6/133 (4%)
Query: 536 SSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESV 595
+S W +++ + ++ G Y+C A R R +++V P Q VT+ +PGE+
Sbjct: 361 NSSWEILRASK-AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV--SPGETA 417
Query: 596 TLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVN 655
L C L +L+W+ R + A+T V L + +L I + +D G Y+CVA N
Sbjct: 418 VLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 474
Query: 656 QQGADHFTVGITV 668
G +V + V
Sbjct: 475 ANGVTRASVWLLV 487
Score = 47.8 bits (112), Expect = 2e-04
Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 8/135 (5%)
Query: 2693 NGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVK 2752
N + + AS + GTY C + G ++V PP++ P P + PG T
Sbjct: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLV--PAPNVTVSPGETAV 418
Query: 2753 LNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMA 2812
L+C +G ++TW + D L A G SL I D G Y+C+A
Sbjct: 419 LSCRVLGEAPYNLTW-VRDWRVLPAST-----GRVAQLADLSLEISGIIPTDGGRYQCVA 472
Query: 2813 KNILGSDSKTTYIHV 2827
N G + ++ V
Sbjct: 473 SNANGVTRASVWLLV 487
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 225 bits (573), Expect = 5e-58
Identities = 248/982 (25%), Positives = 389/982 (39%), Gaps = 57/982 (5%)
Query: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALM-TPNTRIQRFEV 1907
L E P+ ++K +++V A G FV W K + + N RI E
Sbjct: 5606 LKEPPRFVSKL-NSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVEN 5664
Query: 1908 LKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDT 1967
+ TL K + + G+Y+C N G+ + L V +P ++ +TV +G+T
Sbjct: 5665 V--ATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVL--EPAVIVEKAGPMTVTVGET 5720
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVA 2027
+EC GTP + W + D ++ T S ++ +L I D G Y
Sbjct: 5721 CTLECKVAGTPELSVEW-YKDGKL-LTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQV 5778
Query: 2028 SNAAGADSLAIRLHVA--ALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD 2085
N G S + V+ A+PP +L+N G S + C + SV W +
Sbjct: 5779 QNNVGKSSCTAVVDVSDRAVPPSF-TRRLKNTGGVLGASCILECKVAGSSPISVAW-FHE 5836
Query: 2086 GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAAN 2145
T+I S + F TL + +L D G Y CVAAN+ GS L VQ +
Sbjct: 5837 KTKI-VSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSF 5895
Query: 2146 ARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGT 2205
+ P +V G + G P ++ W ++ ++ R ++ T
Sbjct: 5896 VK----EPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKG-----DRCNIYFEDT 5946
Query: 2206 ---LVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLK 2262
L + ++ +G+Y CV N G ++ V +PA K +DH V G +
Sbjct: 5947 VAELELFNIDISQSGEYTCVVSNNAGQASCTTRL-FVKEPAAF-LKRLSDHSVEPGKSII 6004
Query: 2263 VDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDY 2322
++ TG ++W ++ S + + +T + N+ R+ G Y
Sbjct: 6005 LESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNS--------TKRDAGQY 6056
Query: 2323 TCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLS 2382
+C EN+ G+D V + P + L V GD V++ C+ G P V+W
Sbjct: 6057 SCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAV--GDSVSLQCQVAGTPEITVSWYK 6114
Query: 2383 PTNKVIPTSSEK-YQIYQDGTLLIQKAQRSDSGNYTCLVRNSAG-EDRKTVWIHVNVQPP 2440
K+ PT + Y TL+ K +DSG YTC NS G KTV+ Q P
Sbjct: 6115 GDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLP 6174
Query: 2441 KINGNPNPITTVREI-AAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHG 2499
P+ +++I G + C+ G +V W + +GV+L V
Sbjct: 6175 -----PSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCW-YRDGVLLRDDENLQTSFVDN 6228
Query: 2500 NGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH-DPISEKITAMAGH 2558
+L I S S Q C A N G A +LT EP + P F P+S I +AG
Sbjct: 6229 VATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVS--IDVIAGE 6286
Query: 2559 TISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVA 2618
+ C G + W N +++ G L I + D+G Y C A
Sbjct: 6287 SADFECHVTGAQPMRITWSKDN-KEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQA 6345
Query: 2619 RNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMH 2678
N G L V P+ K+ GE+++L C G+ + + SW N
Sbjct: 6346 TNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSW-FRNDSE 6404
Query: 2679 LEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSE 2738
L + LT+ EAS D G Y+C G + S + V A PP T +
Sbjct: 6405 LHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKA-PPVFTQK 6463
Query: 2739 PTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQ 2798
P+PV + G+ V L C G P ++ W + D+ ++ + ++ F SL I
Sbjct: 6464 PSPVGALK-GSDVILQCEISGTPPFEVVW-VKDRKQVRNSKKFKITSKHF---DTSLHIL 6518
Query: 2799 HATQRDAGFYKCMAKNILGSDS 2820
+ D G Y C A N +GSD+
Sbjct: 6519 NLEASDVGEYHCKATNEVGSDT 6540
Score = 223 bits (568), Expect = 2e-57
Identities = 241/1008 (23%), Positives = 397/1008 (39%), Gaps = 73/1008 (7%)
Query: 1838 AGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMT 1897
AG S + E P+ + K + V + T + C+ G P+ V W K T +
Sbjct: 7290 AGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQES 7349
Query: 1898 PNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHY 1957
R+ + + L + + V+D G Y C A N G S+ V++P I
Sbjct: 7350 SKFRMSFVDSV--AVLEMHNLSVEDSGDYTCEAHNAAGSASSST--SLKVKEPPIFRKKP 7405
Query: 1958 QDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHEN--RTLSIKEA 2015
+ G + +EC +GTP +SW + D+R ++ + + EN ++ I
Sbjct: 7406 HPIETLKGADVHLECELQGTPPFHVSW-YKDKRELRSGKKYK---IMSENFLTSIHILNV 7461
Query: 2016 SFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAP 2075
+D G Y+C A+N G+D+ + + A P + +KL +IS G + + T + A
Sbjct: 7462 DAADIGEYQCKATNDVGSDTCVGSIALKAPPRFV--KKLSDISTVVGKEVQLQTTIEGAE 7519
Query: 2076 LPSVRWVLGDGTQIRPSQFLHGNLFVFPN---GTLYIRNLAPKDSGRYECVAANLVGSAR 2132
SV W G +R S N+++ + TL + P ++G+Y C N G
Sbjct: 7520 PISVVWFKDKGEIVRESD----NIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQE 7575
Query: 2133 RTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALF 2192
L+V A P V G T L+C+ +G P W K +
Sbjct: 7576 CFATLSVLEPATIVE----KPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKEL----- 7626
Query: 2193 SFDSRIKV-FAN--GTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDV---VMKPAKIE 2246
+ D++ K+ F N L + +V D+G Y +N VG D + V + P+
Sbjct: 7627 TSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTR 7686
Query: 2247 HKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN 2306
+E + G + ++C G P +SW +G+ ++ SG + + + N
Sbjct: 7687 KLKETNG--LSGSSVVMECKVYGSPPISVSW-FHEGNEIS-------SGRKYQTTLTDNT 7736
Query: 2307 GTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTV 2366
L N + + GDYTC A N G DE + V P+ ++ + V G VT
Sbjct: 7737 CALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPD--PMDVLTGTNVTF 7794
Query: 2367 ACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD-GTLLIQKAQRSDSGNYTCLVRNSAG 2425
KG P V+W +++++P + L + S SG YTC+V N AG
Sbjct: 7795 TSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAG 7854
Query: 2426 EDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVV 2485
+ T +++ P K N + + G +++ G P V W G+
Sbjct: 7855 KASCTTHLYIKA-PAKFVKRLNDYSIEK-----GKPLILEGTFTGTPPISVTWK-KNGIN 7907
Query: 2486 LPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH 2545
+ N T + L+I S D+ Q C N G+ Q+ +LEP P F
Sbjct: 7908 VTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEP---PYFV 7964
Query: 2546 DPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISG 2605
+ E + G + SL C AGTP + W T L+ + + L +
Sbjct: 7965 KQL-EPVKVSVGDSASLQCQLAGTPEIGVSW-YKGDTKLRPTTTYKMHFRNNVATLVFNQ 8022
Query: 2606 LSSVDAGAYRCVARNAAGHTERLVSLKV---GLKPEANKQYHNLVSIINGETLKLPCTPP 2662
+ D+G Y C A N+ G L V L P ++Q ++ + G + C
Sbjct: 8023 VDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETV-GLPVVFDCAIS 8081
Query: 2663 GAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN-GTLTVREASVFDRGTYVCRMETEYGPSV 2721
G+ SW + P + S LDN TL + + G Y C G +
Sbjct: 8082 GSEPISVSWYKDGKPLKDSPNV--QTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSAS 8139
Query: 2722 TSIPVIVI--AYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGV 2779
+S +I+ PP PV G + C G ++W D +++G
Sbjct: 8140 SSARLILTEGKNPPFFDIRLAPVDAV-VGESADFECHVTGTQPIKVSW-AKDSREIRSGG 8197
Query: 2780 QARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ Y +L LT+ + D+G Y C A N +G DS T +++
Sbjct: 8198 K---YQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNI 8242
Score = 214 bits (544), Expect = 1e-54
Identities = 244/1045 (23%), Positives = 413/1045 (39%), Gaps = 63/1045 (6%)
Query: 1788 PLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFW 1847
P+ T + G T + +V++ ++ I I +S + + + AG
Sbjct: 6014 PISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALV 6073
Query: 1848 SLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEV 1907
S E P +T+ + ++ ++ C+ G P+ V+W K T TP R +
Sbjct: 6074 STLEPPYFVTELEPLEAAVGDSVSL-QCQVAGTPEITVSWYKGDTKLRPTPEYRT--YFT 6130
Query: 1908 LKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQ-PQILASHYQDVTVYLGD 1966
TLV KV + D G+Y C A N G + + +Q P A +D+ +G
Sbjct: 6131 NNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGL 6190
Query: 1967 TIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCV 2026
+ + C G+ Q+ W + D + + ++ + TL I + S G Y C
Sbjct: 6191 PVTLTCRLNGSAPIQVCW-YRDGVLLRDDENLQTSF-VDNVATLKILQTDLSHSGQYSCS 6248
Query: 2027 ASNAAGADSLAIRLHVAALPPV---IHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVL 2083
ASN G S + RL A P K +I + G S C A + W
Sbjct: 6249 ASNPLGTASSSARL--TAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSK 6306
Query: 2084 GDGTQIRPSQFLHGNLFVFPNGT---LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ 2140
D +IRP GN + G L I + DSG+Y C A N VG + QL+V+
Sbjct: 6307 -DNKEIRPG----GNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVK 6361
Query: 2141 RAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV 2200
+ S + G +++L+C SG P ++ W + ++ S I
Sbjct: 6362 EPPKFVKKLEASKV---AKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINS 6418
Query: 2201 FANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGD 2260
A L + + +D+GDY+C A N VGD + +K + ++ + G D
Sbjct: 6419 VA--LLTINEASAEDSGDYICEAHNGVGD--ASCSTALTVKAPPVFTQKPSPVGALKGSD 6474
Query: 2261 LKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFN---NGTLYFNEVGMR 2317
+ + C +G P E+ W + NS K++ + + + +L+ +
Sbjct: 6475 VILQCEISGTPPFEVVWVKDRKQVRNS-----------KKFKITSKHFDTSLHILNLEAS 6523
Query: 2318 EEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPK 2377
+ G+Y C A N+VG D VK P ++ + + + GD V + +G
Sbjct: 6524 DVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLI--GDAVELRAIVEGFQPIS 6581
Query: 2378 VTWLSPTNKVIPTSSEKYQIYQDG--TLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHV 2435
V WL +VI S + D TL + + S+SG Y C ++N AG + + V
Sbjct: 6582 VVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTV 6641
Query: 2436 NVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRI 2495
++P +I P P+T G+ ++C G P W F +G L A +
Sbjct: 6642 -LEPARIIEKPEPMTVTT-----GNPFALECVVTGTPELSAKW-FKDGRELSADSKHHIT 6694
Query: 2496 TVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAM 2555
++ SL I SD +N G++ + + V + + P F + + + A+
Sbjct: 6695 FINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKD-VNAI 6753
Query: 2556 AGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYR 2615
G ++ L C +G+ S+ W +G ++ SG + Q + + L++S L D G Y
Sbjct: 6754 LGASVVLECRVSGSAPISVGW-FQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYT 6812
Query: 2616 CVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPN 2675
CVA N AG E L V +P + +Q + V ++ G +L G + W
Sbjct: 6813 CVAANVAGSDECSAVLTV-QEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWF--K 6869
Query: 2676 GMHLEGPQTLGRVSLLDNGT-LTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPR 2734
G P +SL D T L + E + G Y C + + G + S + P
Sbjct: 6870 GSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSA--SCTTHLFVKEPA 6927
Query: 2735 ITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGS 2794
+ G+ + L G P ++W + D+ + Q+
Sbjct: 6928 TFVKRLADFSVETGSPIVLEATYTGTPPISVSW-IKDEYLIS---QSERCSITMTEKSTI 6983
Query: 2795 LTIQHATQRDAGFYKCMAKNILGSD 2819
L I +T D Y C+ +N G D
Sbjct: 6984 LEILESTIEDYAQYSCLIENEAGQD 7008
Score = 213 bits (543), Expect = 2e-54
Identities = 237/970 (24%), Positives = 387/970 (39%), Gaps = 70/970 (7%)
Query: 1873 FPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASN 1932
F CE P W K + I+ + + + L I + QV D G+Y C ASN
Sbjct: 3475 FTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISS--LEILRTQVVDCGEYTCKASN 3532
Query: 1933 LHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVW 1992
+G L+VT P S + +T ++G C GTP + W ++
Sbjct: 3533 EYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIW----QKDG 3588
Query: 1993 QTVSPVEG-RITLHENR-TLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIH 2050
+SP RI+ EN+ L + + DRGVY C ASN GAD L + P I
Sbjct: 3589 AALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFI- 3647
Query: 2051 QEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIR 2110
++LE + +H+ C +V W DG ++ P + + F TL I
Sbjct: 3648 -KELEPVQSAINKKVHLECQVDEDRKVTVTW-SKDGQKLPPGKD-YKICFEDKIATLEIP 3704
Query: 2111 NLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRY----GGTLKL 2166
KDSG Y C A+N GS+ + + V+ + ++ D Y G + +L
Sbjct: 3705 LAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFV-------KKVDPSYLMLPGESARL 3757
Query: 2167 DCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTD---KDAGDYLCVA 2223
C G P ++ W +K + S + ++++ + + +TD +D+G Y C A
Sbjct: 3758 HCKLKGSPVIQVTWFKNNKEL-----SESNTVRMYFVNSEAILDITDVKVEDSGSYSCEA 3812
Query: 2224 RNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGS 2283
N VG D ++ + P+ I+ E D + G + + C +G EISW D
Sbjct: 3813 VNDVGSDSCSTEIVIKEPPSFIKTLEPAD--IVRGTNALLQCEVSGTGPFEISW-FKDKK 3869
Query: 2284 LVNSFMQSDDSGGRTKRYVVFNNGTLYFNEV---GMREEGDYTCFAENQVGKDEMRVRVK 2340
+ S +K+Y +F+ +L E+ + G+Y C N+VGK +
Sbjct: 3870 QIRS----------SKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGC-MATH 3918
Query: 2341 VVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD 2400
++ P T K + + G VT+ +G VTW+ +VI + + +
Sbjct: 3919 LLKEPPTFVKKVDDLIALG-GQTVTLQAAVRGSEPISVTWMK-GQEVIREDGKIKMSFSN 3976
Query: 2401 G--TLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAG 2458
G L+I Q S G YTCL N AG + V +P KI I ++ AG
Sbjct: 3977 GVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVK-EPAKIIERAELI----QVTAG 4031
Query: 2459 GSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGN-GSLDIRSLRKSDSVQLV 2517
L + G P + W ++ + Y RI+ N L S DS Q
Sbjct: 4032 DPATL-EYTVAGTPELKPKWYKDGRPLVASKKY--RISFKNNVAQLKFYSAELHDSGQYT 4088
Query: 2518 CMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWV 2577
NE G + TVL+ P F P+ + ++ T L+C AG+ + W
Sbjct: 4089 FEISNEVGSSSCETTFTVLDRDIAPFFTKPL-RNVDSVVNGTCRLDCKIAGSLPMRVSW- 4146
Query: 2578 LPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP 2637
+G ++ + + + + + L I + DAG + C A N+ G + +L V +P
Sbjct: 4147 FKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIV-QEP 4205
Query: 2638 EANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLT 2697
+ ++ G + L T G+ W N + G L++ +L
Sbjct: 4206 PSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALES-SLE 4264
Query: 2698 VREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMA 2757
+ D GTY C++ G V + + P + P + G+ +L C
Sbjct: 4265 LYLVKTSDSGTYTCKVSNVAG-GVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKV 4323
Query: 2758 MGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILG 2817
G P ITW D+ +K + R+ F+ L + D+G Y C A+N G
Sbjct: 4324 TGTPPIKITWFANDR-EIKESSKHRM---SFVESTAVLRLTDVGIEDSGEYMCEAQNEAG 4379
Query: 2818 SDSKTTYIHV 2827
SD ++ + V
Sbjct: 4380 SDHCSSIVIV 4389
Score = 209 bits (533), Expect = 2e-53
Identities = 240/1026 (23%), Positives = 385/1026 (37%), Gaps = 79/1026 (7%)
Query: 1822 SVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKP 1881
SV+ SG + + A G +S ++P I K P + D CE G P
Sbjct: 7369 SVEDSGDYTCEAHN--AAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTP 7426
Query: 1882 KPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVV 1941
V+W K +I L ++ I V D G+Y C A+N G D V
Sbjct: 7427 PFHVSWYKDKRELRSGKKYKIMSENFLT--SIHILNVDAADIGEYQCKATNDVGSDTCVG 7484
Query: 1942 LLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGR 2001
S+ ++ P D++ +G + ++ +G + W + + +
Sbjct: 7485 --SIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNI--W 7540
Query: 2002 ITLHEN-RTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLP 2060
I+ EN TL ++ G Y C N AG L V L P EK E+I +
Sbjct: 7541 ISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV--LEPATIVEKPESIKVT 7598
Query: 2061 PGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRY 2120
G + + CT P S +W DG ++ + F +G L I N+AP DSG Y
Sbjct: 7599 TGDTCTLECTVAGTPELSTKW-FKDGKELTSDNKYKISFFNKVSG-LKIINVAPSDSGVY 7656
Query: 2121 ECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILW 2180
N VG T L V T + T+ G ++ ++C G P + W
Sbjct: 7657 SFEVQNPVGKDSCTASLQVSDRTVPPSFT-RKLKETNGLSGSSVVMECKVYGSPPISVSW 7715
Query: 2181 -----RLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLK 2235
+ S R + ++ L V + + D+GDY C+A N G D
Sbjct: 7716 FHEGNEISSGRKYQTTLTDNT-------CALTVNMLEESDSGDYTCIATNMAGSDECSAP 7768
Query: 2236 VDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSG 2295
+ V P+ ++ + D V G ++ + G P +SW LV G
Sbjct: 7769 LTVREPPSFVQKPDPMD--VLTGTNVTFTSIVKGTPPFSVSWFKGSSELV--------PG 7818
Query: 2296 GRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA 2355
R + + L +V + G+YTC N+ GK + + APA K
Sbjct: 7819 DRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHL-YIKAPAKF-VKRLND 7876
Query: 2356 VQVPYGDVVTVACEAKGEPMPKVTW------LSPTNKVIPTSSEKYQIYQDGTLLIQKAQ 2409
+ G + + G P VTW ++P+ + T++EK I L I +
Sbjct: 7877 YSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAI-----LEIPSST 7931
Query: 2410 RSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAE 2469
D+G Y C + N++G+D + I + ++PP P+ +++ G S L C+
Sbjct: 7932 VEDAGQYNCYIENASGKDSCSAQILI-LEPPYFVKQLEPV----KVSVGDSASL-QCQLA 7985
Query: 2470 GIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARL 2529
G P V W + + P Y + +L + +DS + +C A N GE
Sbjct: 7986 GTPEIGVSWYKGDTKLRPTTTYKMHFR-NNVATLVFNQVDINDSGEYICKAENSVGEVSA 8044
Query: 2530 ILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQ 2589
LTV E P F + + + G + +C+ +G+ S+ W +G L+
Sbjct: 8045 STFLTVQEQKLPPSFSRQLRD-VQETVGLPVVFDCAISGSEPISVSW-YKDGKPLKDSPN 8102
Query: 2590 LQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNL--- 2646
+Q + L+I AG Y C A N G S ++ L N + ++
Sbjct: 8103 VQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASS--SARLILTEGKNPPFFDIRLA 8160
Query: 2647 -VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGT-LTVREASVF 2704
V + GE+ C G + SW + G + ++S L+N LTV +
Sbjct: 8161 PVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKY--QISYLENSAHLTVLKVDKG 8218
Query: 2705 DRGTYVCRMETEYGPS--VTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPK 2762
D G Y C E G + + PP T + + GN+ KL G
Sbjct: 8219 DSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQP 8278
Query: 2763 ADITWELPDKSHLKAGVQARLYGN---RFLHPQGSLTIQHATQRDAGFYKCMAKNILGSD 2819
+ W K ++ + N F + L ++ A DAG Y C N GS
Sbjct: 8279 ITVAW-------YKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSA 8331
Query: 2820 SKTTYI 2825
T+ I
Sbjct: 8332 LCTSSI 8337
Score = 209 bits (532), Expect = 3e-53
Identities = 237/1006 (23%), Positives = 376/1006 (37%), Gaps = 75/1006 (7%)
Query: 1852 KPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG 1911
+P + + P+++ VT C G P+ W K G +T + + + K
Sbjct: 7584 EPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFK--DGKELTSDNKYKISFFNKVS 7641
Query: 1912 TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQ-PQILASHYQDVTVYLGDTIAM 1970
L I V D G Y N G D L V+ + P ++ G ++ M
Sbjct: 7642 GLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVM 7701
Query: 1971 ECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENR-TLSIKEASFSDRGVYKCVASN 2029
EC G+P +SW + S + + TL +N L++ SD G Y C+A+N
Sbjct: 7702 ECKVYGSPPISVSWFHEGNEI---SSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATN 7758
Query: 2030 AAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI 2089
AG+D + L V P + +K + + + G ++ K P SV W G +++
Sbjct: 7759 MAGSDECSAPLTVREPPSFV--QKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGS-SEL 7815
Query: 2090 RPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARIT 2149
P + +L L + ++ SG Y C+ +N G A T L ++ A +
Sbjct: 7816 VPGDRCNVSL-EDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVK-- 7872
Query: 2150 GTSPRRTD--VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLV 2207
R D + G L L+ + +G P + W+ K I+ S I ++
Sbjct: 7873 ----RLNDYSIEKGKPLILEGTFTGTPPISVTWK---KNGINVTPSQRCNITTTEKSAIL 7925
Query: 2208 -VKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCV 2266
+ S T +DAG Y C N G D ++ ++ P ++ E KV G + C
Sbjct: 7926 EIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPV--KVSVGDSASLQCQ 7983
Query: 2267 ATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFA 2326
G P +SW D L + K + N TL FN+V + + G+Y C A
Sbjct: 7984 LAGTPEIGVSWYKGDTKLRPTTTY--------KMHFRNNVATLVFNQVDINDSGEYICKA 8035
Query: 2327 ENQVGKDEMR--VRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPT 2384
EN VG+ + V+ P + ++ VQ G V C G V+W
Sbjct: 8036 ENSVGEVSASTFLTVQEQKLPPSF-SRQLRDVQETVGLPVVFDCAISGSEPISVSWYKD- 8093
Query: 2385 NKVIPTSSEKYQIYQDGT--LLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNV--QPP 2440
K + S + D T L I K RS +G Y+C N G + + + PP
Sbjct: 8094 GKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPP 8153
Query: 2441 KINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGN 2500
+ P+ V G +C G +V WA + Y + +
Sbjct: 8154 FFDIRLAPVDAVV-----GESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISY-LENS 8207
Query: 2501 GSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTI 2560
L + + K DS Q C A NE G+ QL + E + P F +SE + G++
Sbjct: 8208 AHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSF 8267
Query: 2561 SLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARN 2620
L AG+ ++ W N ++Q + + +L + DAG Y C N
Sbjct: 8268 KLEGRVAGSQPITVAW-YKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSN 8326
Query: 2621 AAGHT--ERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMH 2678
AG + +K KP Q+ V++ GE ++L C G+ R W L G
Sbjct: 8327 DAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQW-LKAGRE 8385
Query: 2679 LEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPP----- 2733
++ L +R+ + D G YVC+ G T V + P
Sbjct: 8386 IKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPAT 8445
Query: 2734 ---------RITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLY 2784
SEP + T G P ++ W L G
Sbjct: 8446 KKAAVDGRLFFVSEPQSIRVVEK-TTATFIAKVGGDPIPNVKWTKGKWRQLNQG------ 8498
Query: 2785 GNRFLHPQG---SLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
G F+H +G L I+ T+ D+G Y+C+A N G + V
Sbjct: 8499 GRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQV 8544
Score = 207 bits (528), Expect = 9e-53
Identities = 228/984 (23%), Positives = 379/984 (38%), Gaps = 72/984 (7%)
Query: 1852 KPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG 1911
+P ++ + ++VT C+ G P+ V W K G L+T + + + K
Sbjct: 5702 EPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYK--DGKLLTSSQKHKFSFYNKIS 5759
Query: 1912 TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQ-PQILASHYQDVTVYLGDTIAM 1970
+L I V+ QD G Y N G ++ V+ + P ++ LG + +
Sbjct: 5760 SLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCIL 5819
Query: 1971 ECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENR-TLSIKEASFSDRGVYKCVASN 2029
EC G+ ++W ++ VS + + T +N TL + SD G Y CVA+N
Sbjct: 5820 ECKVAGSSPISVAWFHEKTKI---VSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAAN 5876
Query: 2030 AAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI 2089
AG+D L V P + + E + + PG ++ + P V W G +
Sbjct: 5877 VAGSDECRAVLTVQEPPSFVKEP--EPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELV 5934
Query: 2090 RPSQFLHGNLFVFPN-GTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARI 2148
+ + N++ L + N+ SG Y CV +N G A T +L V+ AA +
Sbjct: 5935 KGDRC---NIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKR 5991
Query: 2149 TG---TSPRRTDV---RYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFA 2202
P ++ + Y GTL + + W + + + + + + + + I
Sbjct: 5992 LSDHSVEPGKSIILESTYTGTLPISVT-----WKKDGFNITTSEKCNIVTTEKTCI---- 6042
Query: 2203 NGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLK 2262
L + + T +DAG Y C N+ G D V + P + E + V G +
Sbjct: 6043 ---LEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAV--GDSVS 6097
Query: 2263 VDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDY 2322
+ C G P +SW D L + + Y N TL FN+V + + G+Y
Sbjct: 6098 LQCQVAGTPEITVSWYKGDTKLRPT--------PEYRTYFTNNVATLVFNKVNINDSGEY 6149
Query: 2323 TCFAENQVGKDEMRV--RVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTW 2380
TC AEN +G + R++ P + + ++ G VT+ C G +V W
Sbjct: 6150 TCKAENSIGTASSKTVFRIQERQLPPSFA-RQLKDIEQTVGLPVTLTCRLNGSAPIQVCW 6208
Query: 2381 LSPTNKVIPTSSEKYQ---IYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNV 2437
+ V+ E Q + TL I + S SG Y+C N G + +
Sbjct: 6209 Y--RDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSA--RLTA 6264
Query: 2438 QPPKINGNPNPITTVREIA---AGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNR 2494
+ PK +P ++ ++ G +C G R+ W+ + P Y
Sbjct: 6265 REPK----KSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNY--T 6318
Query: 2495 ITVHGN-GSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKIT 2553
IT GN L I + K DS Q C A N+ G+ QL+V EP P F +
Sbjct: 6319 ITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEP---PKFVKKLEASKV 6375
Query: 2554 AMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGA 2613
A G +I L C +G+P + W N ++L + + + +L I+ S+ D+G
Sbjct: 6376 AKQGESIQLECKISGSPEIKVSW-FRNDSELHESWKYNMSFINSVALLTINEASAEDSGD 6434
Query: 2614 YRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTL 2673
Y C A N G +L V P Q + V + G + L C G W +
Sbjct: 6435 YICEAHNGVGDASCSTALTV-KAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVW-V 6492
Query: 2674 PNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPP 2733
+ + + S + +L + D G Y C+ E G S V PP
Sbjct: 6493 KDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSV-KFKEPP 6551
Query: 2734 RITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQG 2793
R + + T G+ V+L + G + W ++ R+ F+
Sbjct: 6552 RFVKKLSDT-STLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRI---SFIDNIA 6607
Query: 2794 SLTIQHATQRDAGFYKCMAKNILG 2817
+L + ++G Y C KN G
Sbjct: 6608 TLQLGSPEASNSGKYICQIKNDAG 6631
Score = 204 bits (519), Expect = 1e-51
Identities = 230/984 (23%), Positives = 380/984 (38%), Gaps = 66/984 (6%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
++P ++P +V V F G P V W K S + + I + +
Sbjct: 6831 QEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTE 6890
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAM 1970
L + +VQ + G Y C +N G L V ++P D +V G I +
Sbjct: 6891 --LELFEVQPLESGDYSCLVTNDAGSASCTTHLFV--KEPATFVKRLADFSVETGSPIVL 6946
Query: 1971 ECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRT-LSIKEASFSDRGVYKCVASN 2029
E GTP +SWI + + Q+ IT+ E T L I E++ D Y C+ N
Sbjct: 6947 EATYTGTPPISVSWIKDEYLISQSE---RCSITMTEKSTILEILESTIEDYAQYSCLIEN 7003
Query: 2030 AAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI 2089
AG D V+ L P E LE++ G + C P + W + T++
Sbjct: 7004 EAGQD--ICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYK-EHTKL 7060
Query: 2090 RPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARIT 2149
R + + F +L I + D G Y C A N VG+ + L V +A
Sbjct: 7061 RSAP-AYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVL-VIKARKLPPFF 7118
Query: 2150 GTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVK 2209
+ G + +C +G ++ W + D S + A TL +
Sbjct: 7119 ARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVA--TLQIL 7176
Query: 2210 SVTDKDAGDYLCVARNKVGDDYVVLKVDVV---------MKPAKIEHKEENDHKVFYGGD 2260
G Y C A N +G K+ + +KP ++ + G
Sbjct: 7177 QTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVD--------LALGES 7228
Query: 2261 LKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEG 2320
C TG +I+W+ + + GG K +V N TL +VG + G
Sbjct: 7229 GTFKCHVTGTAPIKITWAKDNREI--------RPGGNYKMTLVENTATLTVLKVGKGDAG 7280
Query: 2321 DYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTW 2380
YTC+A N GKD ++ V P I+ K + V + C+ G P KV W
Sbjct: 7281 QYTCYASNIAGKDSCSAQLGVQEPPRFIK-KLEPSRIVKQDEFTRYECKIGGSPEIKVLW 7339
Query: 2381 LSPTNKVIPTSSEKYQIYQDGTLLIQKAQRS--DSGNYTCLVRNSAGEDRKTVWIHVNVQ 2438
+ I SS+ + D +++ S DSG+YTC N+AG + + V +
Sbjct: 7340 YKDETE-IQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVK-E 7397
Query: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVH 2498
PP P+PI T++ G+ ++C+ +G P V W + + Y ++ +
Sbjct: 7398 PPIFRKKPHPIETLK-----GADVHLECELQGTPPFHVSWYKDKRELRSGKKY-KIMSEN 7451
Query: 2499 GNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGH 2558
S+ I ++ +D + C A N+ G + + + P P F +S+ I+ + G
Sbjct: 7452 FLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAP---PRFVKKLSD-ISTVVGK 7507
Query: 2559 TISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVA 2618
+ L + G S+VW G ++ + Y + L S + +AG Y C
Sbjct: 7508 EVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQI 7567
Query: 2619 RNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMH 2678
+N AG E +L V L+P + + + G+T L CT G + W +G
Sbjct: 7568 KNDAGMQECFATLSV-LEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKW-FKDGKE 7625
Query: 2679 LEGPQTLGRVSLLDN-GTLTVREASVFDRGTYVCRMETEYGPS--VTSIPVIVIAYPPRI 2735
L ++S + L + + D G Y ++ G S+ V PP
Sbjct: 7626 LTSDNKY-KISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSF 7684
Query: 2736 TSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSL 2795
T + G++V + C G P ++W + + + +G R Y +L
Sbjct: 7685 TRK-LKETNGLSGSSVVMECKVYGSPPISVSW-FHEGNEISSG---RKYQTTLTDNTCAL 7739
Query: 2796 TIQHATQRDAGFYKCMAKNILGSD 2819
T+ + D+G Y C+A N+ GSD
Sbjct: 7740 TVNMLEESDSGDYTCIATNMAGSD 7763
Score = 202 bits (514), Expect = 4e-51
Identities = 236/1037 (22%), Positives = 411/1037 (39%), Gaps = 88/1037 (8%)
Query: 1813 QSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTV 1872
+SS+ SG++ S AGG S + E + K + + T
Sbjct: 4260 ESSLELYLVKTSDSGTYTCKVSNV-AGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQ 4318
Query: 1873 FPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASN 1932
C+ TG P +TW + R+ E L + V ++D G+YMC A N
Sbjct: 4319 LACKVTGTPPIKITWFANDREIKESSKHRMSFVE--STAVLRLTDVGIEDSGEYMCEAQN 4376
Query: 1933 LHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVW 1992
G D + V V++ ++ + V + + GTP +I+W F D +
Sbjct: 4377 EAGSDHCSSI--VIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITW-FKDNTIL 4433
Query: 1993 QTVSPVEGRITLHENRTLSIKEASF--SDRGVYKCVASNAAGADSLAIRLHVAALPPVIH 2050
++ + T ++ +S++ F +D G Y+C +N G+ + R+ + P I
Sbjct: 4434 RSGRKYK---TFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFI- 4489
Query: 2051 QEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNG--TLY 2108
+K+E+ S G + T K + +V W L D +I + F N +LY
Sbjct: 4490 -KKIESTSSLRGGTAAFQATLKGSLPITVTW-LKDSDEITEDDNIR---MTFENNVASLY 4544
Query: 2109 IRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAA------NARITGTSPRRTDVRYGG 2162
+ + K G+Y C A N G R + L+V+ A + +T P V++ G
Sbjct: 4545 LSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSG 4604
Query: 2163 TLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGT---LVVKSVTDKDAGDY 2219
T ++ W + + + S+ K+ T L + S KD+G+Y
Sbjct: 4605 TKEITAK----------WFKDGQEL-----TLGSKYKISVTDTVSILKIISTEKKDSGEY 4649
Query: 2220 LCVARNKVGDDYVVLKV---DVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEIS 2276
+N VG ++ D+++ P+ + ++ D G + ++C+ G I
Sbjct: 4650 TFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDS--IKGSFIDLECIVAGSHPISIQ 4707
Query: 2277 WSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMR 2336
W D Q + + K N L +++ + G YTC A N+ G ++
Sbjct: 4708 WFKDD--------QEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCS 4759
Query: 2337 VRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQ 2396
+ V P + V P V A PM + W NK + + + +
Sbjct: 4760 GHLTVKEPPYFVEKPQSQDVN-PNTRVQLKALVGGTAPMT-IKWFKD-NKELHSGAAR-S 4815
Query: 2397 IYQDGT---LLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVR 2453
+++D T L + A+ +DSG Y C + N G + V +PP+ P+P+ +R
Sbjct: 4816 VWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVK-EPPQFIKKPSPVLVLR 4874
Query: 2454 EIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDS 2513
G +C+ G P RV W + +G + G + I R +S
Sbjct: 4875 N----GQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISF-IDGLATFQISGARVENS 4929
Query: 2514 VQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPS 2573
VC ARN+ G A ++L V EP P F + + + + + L C GTP
Sbjct: 4930 GTYVCEARNDAGTASCSIELKVKEP---PTFIREL-KPVEVVKYSDVELECEVTGTPPFE 4985
Query: 2574 LVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV 2633
+ W L N +++S ++ + LHI+ D G Y+C+ N G S +V
Sbjct: 4986 VTW-LKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCS--CSTRV 5042
Query: 2634 GLK--PEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLL 2691
LK P K+ N +++ + T G+ +W L + L+ + +S +
Sbjct: 5043 ALKEPPSFIKKIENTTTVLK-SSATFQSTVAGSPPISITW-LKDDQILDEDDNV-YISFV 5099
Query: 2692 DN-GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNT 2750
D+ TL +R G Y C+ + E G +++ P +I + V T +
Sbjct: 5100 DSVATLQIRSVDNGHSGRYTCQAKNESGVE-RCYAFLLVQEPAQIVEKAKSVDVTEK-DP 5157
Query: 2751 VKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKC 2810
+ L C+ G P+ + W L D + V +R + F + S IQ ++D+G Y
Sbjct: 5158 MTLECVVAGTPELKVKW-LKDGKQI---VPSRYFSMSFENNVASFRIQSVMKQDSGQYTF 5213
Query: 2811 MAKNILGSDSKTTYIHV 2827
+N GS S Y+ V
Sbjct: 5214 KVENDFGSSSCDAYLRV 5230
Score = 202 bits (513), Expect = 5e-51
Identities = 241/1029 (23%), Positives = 392/1029 (38%), Gaps = 73/1029 (7%)
Query: 1811 STQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETD 1870
ST+ S FI + +GS S+K PP + + P V +
Sbjct: 5487 STEDSGDFICEAQNPAGST-SCSTKVIVKEPP------------VFSSFPPIVETLKNAE 5533
Query: 1871 TVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTA 1930
CE +G P V W K + +I + ++ I V D G+Y C A
Sbjct: 5534 VSLECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNF--HTSIHILNVDTSDIGEYHCKA 5591
Query: 1931 SNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRR 1990
N G D V +V +++P S +TV G+ ++ +G + W+
Sbjct: 5592 QNEVGSDTCVC--TVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEE 5649
Query: 1991 VWQTVSPVEGRITLHEN-RTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVI 2049
V + + RIT EN TL +A ++ G Y C N G L V L P +
Sbjct: 5650 VIRESENI--RITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMV--LEPAV 5705
Query: 2050 HQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYI 2109
EK +++ G + + C P SV W DG + SQ H F +L I
Sbjct: 5706 IVEKAGPMTVTVGETCTLECKVAGTPELSVEWYK-DGKLLTSSQ-KHKFSFYNKISSLRI 5763
Query: 2110 RNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCS 2169
++ +D+G Y N VG + T ++V A T + T G + L+C
Sbjct: 5764 LSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRL-KNTGGVLGASCILECK 5822
Query: 2170 ASGDPWPRILWRLPSKRMIDAL---FSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNK 2226
+G + W +++ +F + TL + S+ D G+Y CVA N
Sbjct: 5823 VAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVC-----TLQLNSLDSSDMGNYTCVAANV 5877
Query: 2227 VGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVN 2286
G D + V P+ + KE +V G ++ V G P +++W LV
Sbjct: 5878 AGSDECRAVLTVQEPPSFV--KEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVK 5935
Query: 2287 SFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPA 2346
G R Y L + + + G+YTC N G+ R+ V A
Sbjct: 5936 --------GDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAA 5987
Query: 2347 TIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIY---QDGTL 2403
++ + +V+ G + + G VTW + T+SEK I + L
Sbjct: 5988 FLKRLSDHSVEP--GKSIILESTYTGTLPISVTWKKDGFNI--TTSEKCNIVTTEKTCIL 6043
Query: 2404 LIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKL 2463
I + + D+G Y+C + N AG D + ++PP P+ AA G
Sbjct: 6044 EILNSTKRDAGQYSCEIENEAGRDVCGALVST-LEPPYFVTELEPLE-----AAVGDSVS 6097
Query: 2464 IDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNE 2523
+ C+ G P V W + + P P Y T + +L + +DS + C A N
Sbjct: 6098 LQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFT-NNVATLVFNKVNINDSGEYTCKAENS 6156
Query: 2524 GGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTD 2583
G A + E P F + + I G ++L C G+ + W +G
Sbjct: 6157 IGTASSKTVFRIQERQLPPSFARQLKD-IEQTVGLPVTLTCRLNGSAPIQVCWYR-DGVL 6214
Query: 2584 LQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQY 2643
L+ + LQ + L I +G Y C A N G S ++ + +
Sbjct: 6215 LRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASS--SARLTAREPKKSPF 6272
Query: 2644 HNL----VSIINGETLKLPCTPPGAGQGRFSWTLPNG-MHLEGPQTLGRVSLLDNGTLTV 2698
++ + +I GE+ C GA R +W+ N + G T+ V + L +
Sbjct: 6273 FDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVG--NTPHLRI 6330
Query: 2699 REASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAM 2758
+ D G Y C+ + G + S + V PP+ + + G +++L C
Sbjct: 6331 LKVGKGDSGQYTCQATNDVGKDMCSAQLSV-KEPPKFVKKLEASKVAKQGESIQLECKIS 6389
Query: 2759 GIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
G P+ ++W D S L ++ Y F++ LTI A+ D+G Y C A N +G
Sbjct: 6390 GSPEIKVSWFRND-SELH---ESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGD 6445
Query: 2819 DSKTTYIHV 2827
S +T + V
Sbjct: 6446 ASCSTALTV 6454
Score = 199 bits (505), Expect = 4e-50
Identities = 239/998 (23%), Positives = 392/998 (39%), Gaps = 73/998 (7%)
Query: 1848 SLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEV 1907
S+ E P+ + K + C+ +G P+ V+W + + + + + +
Sbjct: 6359 SVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFR--NDSELHESWKYNMSFI 6416
Query: 1908 LKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDT 1967
L I + +D G Y+C A N G+ ++TV+ P + V G
Sbjct: 6417 NSVALLTINEASAEDSGDYICEAHN--GVGDASCSTALTVKAPPVFTQKPSPVGALKGSD 6474
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITL-HENRTLSIKEASFSDRGVYKCV 2026
+ ++C GTP ++ W+ DR+ Q + + +IT H + +L I SD G Y C
Sbjct: 6475 VILQCEISGTPPFEVVWV-KDRK--QVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCK 6531
Query: 2027 ASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDG 2086
A+N G+D+ + + P + +KL + S G ++ + + SV W+ G
Sbjct: 6532 ATNEVGSDTCSCSVKFKEPPRFV--KKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRG 6589
Query: 2087 TQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANA 2146
IR S+ + F+ TL + + +SG+Y C N G + L V A
Sbjct: 6590 EVIRESENTRIS-FIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPA--- 6645
Query: 2147 RITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV-FAN-- 2203
RI P V G L+C +G P W + + S DS+ + F N
Sbjct: 6646 RII-EKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGREL-----SADSKHHITFINKV 6699
Query: 2204 GTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDV---VMKPAKIEHKEENDHKVFYGGD 2260
+L + D G Y +N VG + V V ++ P+ I ++ D G
Sbjct: 6700 ASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFI--RKLKDVNAILGAS 6757
Query: 2261 LKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEG 2320
+ ++C +G + W +V SG + + N TL + + + G
Sbjct: 6758 VVLECRVSGSAPISVGWFQDGNEIV--------SGPKCQSSFSENVCTLNLSLLEPSDTG 6809
Query: 2321 DYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTW 2380
YTC A N G DE + V P+ +T +V+V G +T +G P KV W
Sbjct: 6810 IYTCVAANVAGSDECSAVLTVQEPPSF--EQTPDSVEVLPGMSLTFTSVIRGTPPFKVKW 6867
Query: 2381 LSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP 2439
+ +++P S + T L + + Q +SG+Y+CLV N AG T + V
Sbjct: 6868 FKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVK--- 6924
Query: 2440 PKINGNPNPITTVREIA----AGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRI 2495
P T V+ +A GS +++ G P V W E ++ + +
Sbjct: 6925 -------EPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITM 6977
Query: 2496 TVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAM 2555
T L+I D Q C+ NE G+ ++VLEP P F +P+ E + A+
Sbjct: 6978 TEKST-ILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEP---PYFIEPL-EHVEAV 7032
Query: 2556 AGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYR 2615
G +L C GTP + W + T L+S + + L I+ + D G Y
Sbjct: 7033 IGEPATLQCKVDGTPEIRISWYKEH-TKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYS 7091
Query: 2616 CVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLP----CTPPGAGQGRFSW 2671
C A N+ G L + + L + ETL P C G+ + SW
Sbjct: 7092 CKADNSVGAVASSAVLVIKARKLPPFFARKLKDV--HETLGFPVAFECRINGSEPLQVSW 7149
Query: 2672 TLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAY 2731
+G+ L+ L + + TL + + G Y C G + +S +I+ +
Sbjct: 7150 -YKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEH 7208
Query: 2732 --PPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFL 2789
PP +P V G + C G ITW D ++ G Y +
Sbjct: 7209 EVPPFFDLKPVSVDLAL-GESGTFKCHVTGTAPIKITWA-KDNREIRPGGN---YKMTLV 7263
Query: 2790 HPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+LT+ + DAG Y C A NI G DS + + V
Sbjct: 7264 ENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGV 7301
Score = 197 bits (501), Expect = 1e-49
Identities = 230/994 (23%), Positives = 371/994 (37%), Gaps = 68/994 (6%)
Query: 1848 SLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEV 1907
+L E P + K T +V + T F G P +TW K ++ + + V
Sbjct: 5043 ALKEPPSFIKKIENTTTVLKSSAT-FQSTVAGSPPISITWLK--DDQILDEDDNVYISFV 5099
Query: 1908 LKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDT 1967
TL IR V G+Y C A N G++R L VQ+P + + V V D
Sbjct: 5100 DSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFL--LVQEPAQIVEKAKSVDVTEKDP 5157
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLS--IKEASFSDRGVYKC 2025
+ +EC+ GTP ++ W+ ++ + P EN S I+ D G Y
Sbjct: 5158 MTLECVVAGTPELKVKWLKDGKQ----IVPSRYFSMSFENNVASFRIQSVMKQDSGQYTF 5213
Query: 2026 VASNAAGADSLAIRLHV--AALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVL 2083
N G+ S L V +PP +KL + G SIH+ C + S +W
Sbjct: 5214 KVENDFGSSSCDAYLRVLDQNIPPSF-TKKLTKMDKVLGSSIHMECKVSGSLPISAQW-F 5271
Query: 2084 GDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
DG +I S + + + +L + NL +D+ Y C +N+ G + L V+
Sbjct: 5272 KDGKEISTSA-KYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPP 5330
Query: 2144 ANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFAN 2203
+ P R T++ G P +I W ++ F +
Sbjct: 5331 SFL----VKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIG--LEGST 5384
Query: 2204 GTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKV 2263
L + SV G Y C N VG D + +V +P K K E V G ++
Sbjct: 5385 SFLNLYSVDASKTGQYTCHVTNDVGSDSCTTML-LVTEPPKFVKKLEASKIVKAGDSSRL 5443
Query: 2264 DCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYT 2323
+C G P + W + L + + + + + + N + + GD+
Sbjct: 5444 ECKIAGSPEIRVVWFRNEHEL--------PASDKYRMTFIDSVAVIQMNNLSTEDSGDFI 5495
Query: 2324 CFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSP 2383
C A+N G +V V P + + V+ V++ CE G P +V W
Sbjct: 5496 CEAQNPAGSTSCSTKVIVKEPP--VFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKD 5553
Query: 2384 TNKVIPTSSEKYQIYQDG---TLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPP 2440
++ SS+KY+I ++ I SD G Y C +N G D + + +PP
Sbjct: 5554 KRQL--RSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLK-EPP 5610
Query: 2441 KINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGN 2500
+ N +T V G + EG V W + V+ V
Sbjct: 5611 RFVSKLNSLTVV-----AGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENV 5665
Query: 2501 GSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEP---MEKPIFHDPISEKITAMAG 2557
+L +++ + +C +N+GG + L VLEP +EK + +T G
Sbjct: 5666 ATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEK-------AGPMTVTVG 5718
Query: 2558 HTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCV 2617
T +L C AGTP S+ W +G L S Q+ + ++ L I + DAG Y
Sbjct: 5719 ETCTLECKVAGTPELSVEW-YKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQ 5777
Query: 2618 ARNAAGHTERLVSLKV---GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLP 2674
+N G + + V + P ++ N ++ G + L C G+ +W
Sbjct: 5778 VQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVL-GASCILECKVAGSSPISVAWFHE 5836
Query: 2675 NGMHLEGPQTLGRVSLLDN-GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPP 2733
+ G + + + DN TL + D G Y C + S V+ + PP
Sbjct: 5837 KTKIVSGAKY--QTTFSDNVCTLQLNSLDSSDMGNYTC-VAANVAGSDECRAVLTVQEPP 5893
Query: 2734 RITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQG 2793
EP P + PG V + G P + W L G + +Y F
Sbjct: 5894 SFVKEPEP-LEVLPGKNVTFTSVIRGTPPFKVNW-FRGARELVKGDRCNIY---FEDTVA 5948
Query: 2794 SLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
L + + +G Y C+ N G S TT + V
Sbjct: 5949 ELELFNIDISQSGEYTCVVSNNAGQASCTTRLFV 5982
Score = 194 bits (494), Expect = 8e-49
Identities = 235/1009 (23%), Positives = 391/1009 (38%), Gaps = 93/1009 (9%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
E PQ+L + Q V+V + F +G+P+P ++W K L++ + + +
Sbjct: 3237 EPPQVLQEL-QPVTVQSGKPARFCAVISGRPQPKISWYKEEQ--LLSTGFKCKFLHDGQE 3293
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQ-----------PQILASHYQD 1959
TL++ + +D Y C A N +G+ LSV V + P + + QD
Sbjct: 3294 YTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQD 3353
Query: 1960 VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSD 2019
G +C GT ++SW D+++ S + L I EA D
Sbjct: 3354 TVTSEGQPARFQCRVSGTDL-KVSWYSKDKKI--KPSRFFRMTQFEDTYQLEIAEAYPED 3410
Query: 2020 RGVYKCVASNAAGADSLAIRLHVAALPPVIHQ-----------------EKLENISLPPG 2062
G Y VASNA G S L + A ++H+ K+E + + G
Sbjct: 3411 EGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALG 3470
Query: 2063 LSIHIHCTAKAAPLPSVRWVL-------GDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPK 2115
C ++AP +W D IR S+++ +L I
Sbjct: 3471 HLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYI---------SSLEILRTQVV 3521
Query: 2116 DSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPW 2175
D G Y C A+N GS T L V A + + P+ G K C+ +G P
Sbjct: 3522 DCGEYTCKASNEYGSVSCTATLTVTEAYPPTFL--SRPKSLTTFVGKAAKFICTVTGTPV 3579
Query: 2176 PRILWRLPSKRMIDALFSFDSRIKVFAN-GTLVVKSVTDKDAGDYLCVARNKVGDDYVVL 2234
+W+ + S + RI N L + ++T +D G Y C A NK G D
Sbjct: 3580 IETIWQKDGAALSP---SPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQA 3636
Query: 2235 KVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDS 2294
++ ++ KP I+ E + + ++C ++WS DG Q
Sbjct: 3637 ELIIIDKPHFIKELEPVQSAI--NKKVHLECQVDEDRKVTVTWS-KDG-------QKLPP 3686
Query: 2295 GGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYL 2354
G K TL +++ G Y C A N+ G V V P+ ++
Sbjct: 3687 GKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPS 3746
Query: 2355 AVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSS--EKYQIYQDGTLLIQKAQRSD 2412
+ +P G+ + C+ KG P+ +VTW NK + S+ Y + + L I + D
Sbjct: 3747 YLMLP-GESARLHCKLKGSPVIQVTWFK-NNKELSESNTVRMYFVNSEAILDITDVKVED 3804
Query: 2413 SGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIP 2472
SG+Y+C N G D + I + +PP P VR G+ L+ C+ G
Sbjct: 3805 SGSYSCEAVNDVGSDSCSTEIVIK-EPPSFIKTLEPADIVR-----GTNALLQCEVSGTG 3858
Query: 2473 TPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQ 2532
+ W + + + Y + L+I S +D + C+ NE G+ +
Sbjct: 3859 PFEISWFKDKKQIRSSKKY-RLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGCMAT 3917
Query: 2533 LTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQR 2592
+ EP P F + + I A+ G T++L + G+ S+ W+ + G +++
Sbjct: 3918 HLLKEP---PTFVKKVDDLI-ALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDG-KIKM 3972
Query: 2593 FYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIING 2652
+ +L I + G Y C+A N AG ++ V + +P + L+ + G
Sbjct: 3973 SFSNGVAVLIIPDVQISFGGKYTCLAENEAG-SQTSVGELIVKEPAKIIERAELIQVTAG 4031
Query: 2653 ETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN-GTLTVREASVFDRGTYVC 2711
+ L T G + + W +G L + R+S +N L A + D G Y
Sbjct: 4032 DPATLEYTVAGTPELKPKW-YKDGRPLVASKKY-RISFKNNVAQLKFYSAELHDSGQYTF 4089
Query: 2712 RMETEYGPS--VTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWEL 2769
+ E G S T+ V+ P T +P + + T +L+C G ++W
Sbjct: 4090 EISNEVGSSSCETTFTVLDRDIAPFFT-KPLRNVDSVVNGTCRLDCKIAGSLPMRVSW-F 4147
Query: 2770 PDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
D + A + R+ F+ SL I DAG + C A N +GS
Sbjct: 4148 KDGKEIAASDRYRI---AFVEGTASLEIIRVDMNDAGNFTCRATNSVGS 4193
Score = 191 bits (485), Expect = 9e-48
Identities = 217/986 (22%), Positives = 399/986 (40%), Gaps = 71/986 (7%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
++P + + + + VTA G P+ W K + + RI KN
Sbjct: 4014 KEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRIS----FKN 4069
Query: 1911 GTLVIR--KVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQ-PQILASHYQDVTVYLGDT 1967
++ ++ D GQY SN G +V + ++V + T
Sbjct: 4070 NVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGT 4129
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQT----VSPVEGRITLHENRTLSIKEASFSDRGVY 2023
++C G+ ++SW + + + ++ VEG +L I +D G +
Sbjct: 4130 CRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEG------TASLEIIRVDMNDAGNF 4183
Query: 2024 KCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVL 2083
C A+N+ G+ + L V P + + +++ PG ++ + T + + ++RW
Sbjct: 4184 TCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVL--PGSAVCLKSTFQGSTPLTIRWFK 4241
Query: 2084 GDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
G+ + + + LY+ + DSG Y C +N+ G + L V+ A
Sbjct: 4242 GNKELVSGGSCYITKEALESSLELYL--VKTSDSGTYTCKVSNVAGGVECSANLFVKEPA 4299
Query: 2144 ANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFAN 2203
S ++ G +L C +G P +I W + + ++ F
Sbjct: 4300 TFVEKLEPSQL---LKKGDATQLACKVTGTPPIKITWFANDREIKES----SKHRMSFVE 4352
Query: 2204 GTLVVKSVTD---KDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGD 2260
T V++ +TD +D+G+Y+C A+N+ G D+ V++K + KE +V D
Sbjct: 4353 STAVLR-LTDVGIEDSGEYMCEAQNEAGSDHC--SSIVIVKESPYFTKEFKPIEVLKEYD 4409
Query: 2261 LKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEG 2320
+ + G P EI+W D +++ S G + K ++ + +L + + G
Sbjct: 4410 VMLLAEVAGTPPFEITW-FKDNTILRS-------GRKYKTFIQDHLVSLQILKFVAADAG 4461
Query: 2321 DYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTW 2380
+Y C N+VG RV + P+ I K + G KG VTW
Sbjct: 4462 EYQCRVTNEVGSSICSARVTLREPPSFI--KKIESTSSLRGGTAAFQATLKGSLPITVTW 4519
Query: 2381 LSPTNKVIPTSSEKYQIYQD-GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP 2439
L ++++ + + + +L + + G Y C +N AG R + + V +P
Sbjct: 4520 LKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVK-EP 4578
Query: 2440 PKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEG--VVLPAPYYGNRITV 2497
I I + G + K G W F +G + L + Y +I+V
Sbjct: 4579 ATITEEAVSIDVTQ-----GDPATLQVKFSGTKEITAKW-FKDGQELTLGSKY---KISV 4629
Query: 2498 HGNGS-LDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMA 2556
S L I S K DS + +N+ G + ++ VL+ + P F + +K+ ++
Sbjct: 4630 TDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKL-KKMDSIK 4688
Query: 2557 GHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRC 2616
G I L C AG+ S+ W + ++ + ++ + +H L IS L D+G Y C
Sbjct: 4689 GSFIDLECIVAGSHPISIQW-FKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTC 4747
Query: 2617 VARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGET-LKLPCTPPGAGQGRFSWTLPN 2675
A N AGH + L V P ++ + +N T ++L G W N
Sbjct: 4748 SATNKAGHNQCSGHLTVKEPPYFVEKPQS--QDVNPNTRVQLKALVGGTAPMTIKWFKDN 4805
Query: 2676 G-MHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPR 2734
+H +++ + + +L + A D GTY+C++ + G + TS + + PP+
Sbjct: 4806 KELHSGAARSVWKDDT--STSLELFAAKATDSGTYICQLSNDVG-TATSKATLFVKEPPQ 4862
Query: 2735 ITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGS 2794
+P+PV+ R G + C G PK ++W L D + + A + +G F+ +
Sbjct: 4863 FIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYL-DGNEITA---IQKHGISFIDGLAT 4918
Query: 2795 LTIQHATQRDAGFYKCMAKNILGSDS 2820
I A ++G Y C A+N G+ S
Sbjct: 4919 FQISGARVENSGTYVCEARNDAGTAS 4944
Score = 186 bits (471), Expect = 4e-46
Identities = 235/992 (23%), Positives = 370/992 (37%), Gaps = 70/992 (7%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRI--QRFEVLKN 1910
P + T+ P V +D + CE +G P V W K + +I + F+
Sbjct: 6457 PPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDT--- 6513
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAM 1970
+L I ++ D G+Y C A+N G D SV ++P D + +GD + +
Sbjct: 6514 -SLHILNLEASDVGEYHCKATNEVGSD--TCSCSVKFKEPPRFVKKLSDTSTLIGDAVEL 6570
Query: 1971 ECLAKGTPAPQISWIFPDRRVWQTVSPVEG-RITLHEN-RTLSIKEASFSDRGVYKCVAS 2028
+ +G + W+ DR + + E RI+ +N TL + S+ G Y C
Sbjct: 6571 RAIVEGFQPISVVWL-KDRG--EVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIK 6627
Query: 2029 NAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQ 2088
N AG + L V L P EK E +++ G + C P S +W DG +
Sbjct: 6628 NDAGMRECSAVLTV--LEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKW-FKDGRE 6684
Query: 2089 IRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARI 2148
+ H F+ +L I D G Y N VG + TV ++V + RI
Sbjct: 6685 LSADS-KHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV-----SDRI 6738
Query: 2149 TGTSPRRT--DVR--YGGTLKLDCSASGDPWPRILWRLPSKRMIDA---LFSFDSRIKVF 2201
S R DV G ++ L+C SG + W ++ SF +
Sbjct: 6739 VPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVC-- 6796
Query: 2202 ANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDL 2261
TL + + D G Y CVA N G D V V +P E ++ +V G L
Sbjct: 6797 ---TLNLSLLEPSDTGIYTCVAANVAGSDECSA-VLTVQEPPSFEQTPDSV-EVLPGMSL 6851
Query: 2262 KVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGD 2321
V G P ++ W LV + + +V L EV E GD
Sbjct: 6852 TFTSVIRGTPPFKVKWFKGSRELV----PGESCNISLEDFVT----ELELFEVQPLESGD 6903
Query: 2322 YTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWL 2381
Y+C N G + V PAT K V G + + G P V+W+
Sbjct: 6904 YSCLVTNDAGSASCTTHL-FVKEPATFV-KRLADFSVETGSPIVLEATYTGTPPISVSWI 6961
Query: 2382 SPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPP 2440
+ + + + T+L I ++ D Y+CL+ N AG+D + V ++PP
Sbjct: 6962 KDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSV-LEPP 7020
Query: 2441 KINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGN 2500
P+ V + G + CK +G P R+ W + AP Y + +
Sbjct: 7021 YFI---EPLEHVEAVI--GEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFK-NNV 7074
Query: 2501 GSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTI 2560
SL I + SD + C A N G L + P F + + + G +
Sbjct: 7075 ASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKD-VHETLGFPV 7133
Query: 2561 SLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARN 2620
+ C G+ + W +G L+ LQ + L I G Y C A N
Sbjct: 7134 AFECRINGSEPLQVSWY-KDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASN 7192
Query: 2621 AAGHTERLVSLKVGLKPEANKQYHNL----VSIINGETLKLPCTPPGAGQGRFSWTLPNG 2676
G S K+ L + +L V + GE+ C G + +W N
Sbjct: 7193 PLGTASS--SAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNR 7250
Query: 2677 MHLEGPQTLGRVSLLDN-GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRI 2735
G +++L++N TLTV + D G Y C G S + + PPR
Sbjct: 7251 EIRPGGNY--KMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQ-LGVQEPPRF 7307
Query: 2736 TSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSL 2795
+ P + + C G P+ + W D++ ++ + R+ F+ L
Sbjct: 7308 IKKLEPSRIVKQDEFTRYECKIGGSPEIKVLW-YKDETEIQESSKFRM---SFVDSVAVL 7363
Query: 2796 TIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ + + D+G Y C A N GS S +T + V
Sbjct: 7364 EMHNLSVEDSGDYTCEAHNAAGSASSSTSLKV 7395
Score = 186 bits (471), Expect = 4e-46
Identities = 205/862 (23%), Positives = 334/862 (38%), Gaps = 81/862 (9%)
Query: 1838 AGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMT 1897
AG S ++ E P + K P + V T+ F G P V+W K S+ +
Sbjct: 7760 AGSDECSAPLTVREPPSFVQK-PDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSE--LV 7816
Query: 1898 PNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHY 1957
P R L + V G+Y C SN G + + ++ P
Sbjct: 7817 PGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAG--KASCTTHLYIKAPAKFVKRL 7874
Query: 1958 QDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVE--GRITLHENRTLSIKEA 2015
D ++ G + +E GTP ++W ++ V+P + T ++ L I +
Sbjct: 7875 NDYSIEKGKPLILEGTFTGTPPISVTW----KKNGINVTPSQRCNITTTEKSAILEIPSS 7930
Query: 2016 SFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAP 2075
+ D G Y C NA+G DS + ++ + L P ++LE + + G S + C P
Sbjct: 7931 TVEDAGQYNCYIENASGKDSCSAQILI--LEPPYFVKQLEPVKVSVGDSASLQCQLAGTP 7988
Query: 2076 LPSVRWVLGDGTQIRPSQFLHGNLFVFPNG--TLYIRNLAPKDSGRYECVAANLVGSARR 2133
V W GD T++RP+ + F N TL + DSG Y C A N VG
Sbjct: 7989 EIGVSWYKGD-TKLRPTTTYKMH---FRNNVATLVFNQVDINDSGEYICKAENSVGEVSA 8044
Query: 2134 TVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFS 2193
+ L VQ + R G + DC+ SG + W K + D S
Sbjct: 8045 STFLTVQEQKLPPSFS-RQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKD---S 8100
Query: 2194 FDSRIKVFANGTLVVKSVTDKD-AGDYLCVARNKVGDDYVVLKV-----------DVVMK 2241
+ + N + TD+ AG Y C A N +G ++ D+ +
Sbjct: 8101 PNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLA 8160
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P E D +C TG ++SW+ + SGG+ +
Sbjct: 8161 PVDAVVGESADF----------ECHVTGTQPIKVSWAKDSREI--------RSGGKYQIS 8202
Query: 2302 VVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEM--RVRVKVVTAPATIRNKTYLAVQVP 2359
+ N+ L +V + G YTC+A N+VGKD ++ +K P + + V+
Sbjct: 8203 YLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEET 8262
Query: 2360 YGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQ--KAQRSDSGNYT 2417
G+ + G V W ++ PTS+ + +++ TL++Q KA +D+G YT
Sbjct: 8263 EGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEIT-FKNNTLVLQVRKAGMNDAGLYT 8321
Query: 2418 CLVRNSAGEDRKTVWIHVNV--QPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPR 2475
C V N AG T I + +PP + + P+T + G + C +G R
Sbjct: 8322 CKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTV-----SEGEYVQLSCHVQGSEPIR 8376
Query: 2476 VLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535
+ W + P+ G L++R + K+DS VC A N G ++T+
Sbjct: 8377 IQWLKAGREIKPSDRCSFSFA-SGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTI 8435
Query: 2536 LE-PMEKP----------IFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
+ P P +F + I + T + G P P++ W L
Sbjct: 8436 KDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQL 8495
Query: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYH 2644
G ++ + L I + D+G YRCVA N G E V+L+V + + K
Sbjct: 8496 NQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEG 8555
Query: 2645 NLVSIINGETLKLPCTPPGAGQ 2666
+L +++ K P GAG+
Sbjct: 8556 DLRAMLK----KTPILKKGAGE 8573
Score = 181 bits (458), Expect = 1e-44
Identities = 224/950 (23%), Positives = 358/950 (37%), Gaps = 88/950 (9%)
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMEC 1972
+ I + + D G+Y A G +R V L V +P + Q VTV G
Sbjct: 3205 MFISETRQSDAGEYTFVA----GRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCA 3260
Query: 1973 LAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENR--TLSIKEASFSDRGVYKCVASNA 2030
+ G P P+ISW + + ++ T + LH+ + TL + EA D VY C A N
Sbjct: 3261 VISGRPQPKISW-YKEEQLLSTGFKCK---FLHDGQEYTLLLIEAFPEDAAVYTCEAKND 3316
Query: 2031 AGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPS------------ 2078
G + + L V +P V+ ++ E PP + + T + P+
Sbjct: 3317 YGVATTSASLSV-EVPEVVSPDQ-EMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLK 3374
Query: 2079 VRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLN 2138
V W D +I+PS+F F L I P+D G Y VA+N VG T L+
Sbjct: 3375 VSWYSKD-KKIKPSRFFRMTQFE-DTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLS 3432
Query: 2139 ---------------VQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLP 2183
++ A + +V G K C P R W
Sbjct: 3433 LEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKA 3492
Query: 2184 SKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPA 2243
+ + ++ K ++ ++ V D G+Y C A N+ G + V
Sbjct: 3493 GREIYESDKCSIRSSKYISSLEILRTQVV--DCGEYTCKASNEYGSVSCTATLTVTEAYP 3550
Query: 2244 KIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVV 2303
F G K C TG P E W DG+ ++ S K +
Sbjct: 3551 PTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQ-KDGAALSPSPNWRISDAENKHILE 3609
Query: 2304 FNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDV 2363
+N T+ ++ G Y+C A N+ G D + + ++ P I K VQ
Sbjct: 3610 LSNLTI-------QDRGVYSCKASNKFGADICQAELIIIDKPHFI--KELEPVQSAINKK 3660
Query: 2364 VTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD--GTLLIQKAQRSDSGNYTCLVR 2421
V + C+ + VTW K+ P K ++D TL I A+ DSG Y C
Sbjct: 3661 VHLECQVDEDRKVTVTWSKDGQKLPPGKDYKI-CFEDKIATLEIPLAKLKDSGTYVCTAS 3719
Query: 2422 NSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFP 2481
N AG + + V +PP +P + G + CK +G P +V W F
Sbjct: 3720 NEAGSSSCSATVTVR-EPPSFVKKVDP----SYLMLPGESARLHCKLKGSPVIQVTW-FK 3773
Query: 2482 EGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEK 2541
L V+ LDI ++ DS C A N+ G ++ + EP
Sbjct: 3774 NNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEP--- 3830
Query: 2542 PIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGML 2601
P F + E + G L C +GT + W + ++S ++ + F K+ L
Sbjct: 3831 PSFIKTL-EPADIVRGTNALLQCEVSGTGPFEISW-FKDKKQIRSSKKYRLFSQKSLVCL 3888
Query: 2602 HISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTP 2661
I +S D G Y CV N G + + + P K+ +L++ + G+T+ L
Sbjct: 3889 EIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIA-LGGQTVTLQAAV 3947
Query: 2662 PGAGQGRFSWTLPNGMHLEGPQTL---GRVSL-LDNG--TLTVREASVFDRGTYVCRMET 2715
G+ +W ++G + + G++ + NG L + + + G Y C E
Sbjct: 3948 RGSEPISVTW-------MKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAEN 4000
Query: 2716 EYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHL 2775
E G S TS+ +++ P +I E +I G+ L G P+ W +
Sbjct: 4001 EAG-SQTSVGELIVKEPAKII-ERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPL- 4057
Query: 2776 KAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDS-KTTY 2824
V ++ Y F + L A D+G Y N +GS S +TT+
Sbjct: 4058 ---VASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTF 4104
Score = 154 bits (388), Expect = 2e-36
Identities = 234/1023 (22%), Positives = 390/1023 (38%), Gaps = 76/1023 (7%)
Query: 1821 SSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGK 1880
+ ++ SG++ ++S AG S ++ E P + K + + C+ G
Sbjct: 3706 AKLKDSGTYVCTASNE-AGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGS 3764
Query: 1881 PKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMV 1940
P VTW K + L NT ++ + V L I V+V+D G Y C A N G D
Sbjct: 3765 PVIQVTWFK-NNKELSESNT-VRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCS 3822
Query: 1941 VLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEG 2000
+ +++P + + G ++C GT +ISW F D++ Q S +
Sbjct: 3823 T--EIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISW-FKDKK--QIRSSKKY 3877
Query: 2001 RITLHENRT-LSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISL 2059
R+ ++ L I + +D G Y+CV +N G + H+ PP +K++++
Sbjct: 3878 RLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCG-CMATHLLKEPPTF-VKKVDDLIA 3935
Query: 2060 PPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNG--TLYIRNLAPKDS 2117
G ++ + + + SV W+ G IR + F NG L I ++
Sbjct: 3936 LGGQTVTLQAAVRGSEPISVTWMKGQEV-IREDGKIK---MSFSNGVAVLIIPDVQISFG 3991
Query: 2118 GRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPR 2177
G+Y C+A N GS +L V+ A V G L+ + +G P +
Sbjct: 3992 GKYTCLAENEAGSQTSVGELIVKEPAKIIE----RAELIQVTAGDPATLEYTVAGTPELK 4047
Query: 2178 ILWRLPSKRMIDALFSFDSRIKVFANGTLVVK--SVTDKDAGDYLCVARNKVGDD----- 2230
W + ++ S RI F N +K S D+G Y N+VG
Sbjct: 4048 PKWYKDGRPLV---ASKKYRIS-FKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETT 4103
Query: 2231 YVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQ 2290
+ VL D+ A K + G ++DC G +SW F
Sbjct: 4104 FTVLDRDI----APFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSW----------FKD 4149
Query: 2291 SDDSGGRTKRYVVFNNGT--LYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATI 2348
+ + + F GT L V M + G++TC A N VG + + V P+ +
Sbjct: 4150 GKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFV 4209
Query: 2349 RNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQ--DGTLLIQ 2406
+ V G V + +G + W NK + + Y + + +L +
Sbjct: 4210 TKPG--SKDVLPGSAVCLKSTFQGSTPLTIRWFK-GNKELVSGGSCYITKEALESSLELY 4266
Query: 2407 KAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466
+ SDSG YTC V N AG + + V +P P +++ G + C
Sbjct: 4267 LVKTSDSGTYTCKVSNVAGGVECSANLFVK-EPATFVEKLEPSQLLKK----GDATQLAC 4321
Query: 2467 KAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGE 2526
K G P ++ W F + V L + + DS + +C A+NE G
Sbjct: 4322 KVTGTPPIKITW-FANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGS 4380
Query: 2527 ARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQS 2586
+++ E P F + I + + + L AGTP + W N T L+S
Sbjct: 4381 DHC---SSIVIVKESPYFTKEF-KPIEVLKEYDVMLLAEVAGTPPFEITWFKDN-TILRS 4435
Query: 2587 GQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLK-PEANKQYHN 2645
G++ + F L I + DAG Y+C N G + + S +V L+ P + +
Sbjct: 4436 GRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSS--ICSARVTLREPPSFIKKIE 4493
Query: 2646 LVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN-GTLTVREASVF 2704
S + G T T G+ +W + E R++ +N +L + V
Sbjct: 4494 STSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNI--RMTFENNVASLYLSGIEVK 4551
Query: 2705 DRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKAD 2764
G YVC+ + + G S ++ + P IT E + T+ G+ L G +
Sbjct: 4552 HDGKYVCQAKNDAGIQRCS-ALLSVKEPATITEEAVSIDVTQ-GDPATLQVKFSGTKEIT 4609
Query: 2765 ITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTY 2824
W D L G + Y L I ++D+G Y +N +G S
Sbjct: 4610 AKW-FKDGQELTLGSK---YKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKAR 4665
Query: 2825 IHV 2827
I+V
Sbjct: 4666 INV 4668
Score = 98.6 bits (244), Expect = 8e-20
Identities = 195/916 (21%), Positives = 312/916 (34%), Gaps = 203/916 (22%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P +TK P + VF C+ G PKP V W K P T R++V N
Sbjct: 1082 PYFITK-PVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV-----PLTTGYRYKVSYNKQ 1135
Query: 1913 -----LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDT 1967
LVI D G+Y N HG L ++L Q++ T
Sbjct: 1136 TGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADY-ELLMKSQQEMLYQTQVT 1194
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRI--------TLHENRTLSIKEASFSD 2019
++ G AP + ++ + + + ++ T E++ I +SF +
Sbjct: 1195 AFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHI--SSFEE 1252
Query: 2020 RGV----YKCVASNAA------GADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHC 2069
R + Y+ + + G + +A+ + + +++N + G+ + HC
Sbjct: 1253 RLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHC 1312
Query: 2070 TAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVG 2129
PLP + W DG +I+ + + +L I + P+D G Y A+N+ G
Sbjct: 1313 KMSGYPLPKIAWYK-DGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKG 1371
Query: 2130 SARRTVQLNVQRAAAN------------ARITGTSPR---RTDVRYGGTLKLDCSASGDP 2174
+A + +L V+ AA +RI SPR R+ +R P
Sbjct: 1372 NAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMS------------P 1419
Query: 2175 WPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVL 2234
R+ RM A S R++ TD+ + L
Sbjct: 1420 ARMSPARMSPARMSPARMSPGRRLEE-----------TDESQLERL-------------Y 1455
Query: 2235 KVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDS 2294
K V+KP K G + D G P PE W +VN +
Sbjct: 1456 KPVFVLKPVSF--------KCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDY------ 1501
Query: 2295 GGRTKRYVVFNNGT--LYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRN-- 2350
T + V+ +GT L + G++T A+N+ G+ + V + V ++
Sbjct: 1502 ---THKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMF 1558
Query: 2351 -KTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQI---YQDGTLLIQ 2406
+ V + G + + A G P P + WL ++ ++P K +I + L I
Sbjct: 1559 VEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKID 1618
Query: 2407 KAQRSDSGNYTCLVRNSAGEDRKTVWIHVNV-----QPPKINGNPNPITTVREIAAGGSR 2461
DS YT N AG D ++V V +P + P +EIAA
Sbjct: 1619 STVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTYRAKEIAAPELE 1678
Query: 2462 KL-----------------------------------------IDCKAE--GIPTPRVLW 2478
L +C+ G PT V W
Sbjct: 1679 PLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEW 1738
Query: 2479 AFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG----EARLILQ-- 2532
+G L A I G SLD DS + C A N+ G A LI++
Sbjct: 1739 -LHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDE 1797
Query: 2533 ---------------LTVLEPMEKPIFHDPIS------------------EKITAMAGHT 2559
L +E +E+ ++ E + + G T
Sbjct: 1798 KSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGET 1857
Query: 2560 ISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM--LHISGLSSVDAGAYRCV 2617
C G P P + W L NG Q ++ +RF + DG+ L I S D G +
Sbjct: 1858 ARFRCRVTGYPQPKVNWYL-NG---QLIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVT 1913
Query: 2618 ARNAAGHTERLVSLKV 2633
A N G E V L++
Sbjct: 1914 AENPEGVIEHKVKLEI 1929
Score = 98.2 bits (243), Expect = 1e-19
Identities = 141/678 (20%), Positives = 246/678 (36%), Gaps = 85/678 (12%)
Query: 1794 QTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWS-LGEK 1852
+ +G T+ N+ + SI S + + Q +++ K + K
Sbjct: 32792 EISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSK 32851
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P I+T Q +V++++ F +ATG+P+P WTK G +T + + E
Sbjct: 32852 PVIVT-GLQDTTVSSDSVAKFAVKATGEPRPTAIWTK--DGKAITQGGKYKLSEDKGGFF 32908
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMEC 1972
L I K D G Y CT N G L++ + DT A +
Sbjct: 32909 LEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKA----------------IKDTEAQKV 32952
Query: 1973 LAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIK--EASFSDRGVYKCVASNA 2030
+ T S I P ++ + V+ I+ R+ IK EA ++ K AS
Sbjct: 32953 STQKT-----SEITPQKK-----AVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKV 33002
Query: 2031 AGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTA-----------------KA 2073
++ + + ++H+E + + H A
Sbjct: 33003 LISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANI 33062
Query: 2074 APLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARR 2133
A V+WVL ++ +G + TL I+ + +D G C++ G +
Sbjct: 33063 AGATDVKWVLNGVELTNSEEYRYG--VSGSDQTLTIKQASHRDEGILTCISKTKEGIVKC 33120
Query: 2134 TVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILW---RLPSKRMIDA 2190
L + + ++A + PR ++ G + C SG+P P I W LP I +
Sbjct: 33121 QYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPIS--ISS 33178
Query: 2191 LFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYV---VLKVDVVMKPAKIEH 2247
S V++ L +++ + D+G Y A+N G ++ + +V +P++ E
Sbjct: 33179 NVSISRSRNVYS---LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSR-EV 33234
Query: 2248 KEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSF-------MQSDDSGGRTKR 2300
G V E S+S S +S M + +
Sbjct: 33235 VLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQES 33294
Query: 2301 YVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPY 2360
+V ++ + +G+ + + K+ P+ I +
Sbjct: 33295 FVEMSSSSF----MGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDI--------SIDE 33342
Query: 2361 GDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDG---TLLIQKAQRSDSGNYT 2417
G V+TVAC GEP P+VTW K+ ++ I TL+I Q+ D G YT
Sbjct: 33343 GKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYT 33402
Query: 2418 CLVRNSAGEDRKTVWIHV 2435
+ N G D TV IH+
Sbjct: 33403 LSLGNEFGSDSATVNIHI 33420
Score = 77.4 bits (189), Expect = 2e-13
Identities = 163/710 (22%), Positives = 250/710 (35%), Gaps = 134/710 (18%)
Query: 2040 LHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNL 2099
+ + PP + L+N+++ G S+ + C P P+V W D QI S
Sbjct: 936 VEIPVTPPTL-VSGLKNVTVIEGESVTLECHISGYPSPTVTWYRED-YQIESSIDFQ--- 990
Query: 2100 FVFPNGT--LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ--------RAAANARIT 2149
F +G L IR +DSGR+ C A N G+ + L VQ A + T
Sbjct: 991 ITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFT 1050
Query: 2150 GTSPRRTDVR----------------------------------YGGTLKLDCSASGDPW 2175
R + R GG++ C G+P
Sbjct: 1051 TEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPK 1110
Query: 2176 PRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLK 2235
P + W+ + S K LV+ DAG+Y V RNK G+
Sbjct: 1111 PHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASAS 1170
Query: 2236 VDVVMKPAKIEHKEENDHKVFYGGDL-------KVDCVATGLPNPEISWSL-PDGSLVNS 2287
+++ A E ++ ++ Y + KV A G E + +L+
Sbjct: 1171 ---LLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRK 1227
Query: 2288 FMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDY----TCFAE--NQVGKDEMRVRV-- 2339
M D RT YV + E + +E +Y T E + G+++M V +
Sbjct: 1228 KMAKDTVVVRT--YVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISE 1285
Query: 2340 -KVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQI- 2397
+ V + R K Y ++ G VT C+ G P+PK+ W ++ E+YQ+
Sbjct: 1286 SEAVESGFDSRIKNYRILE---GMGVTFHCKMSGYPLPKIAWYKDGKRI--KHGERYQMD 1340
Query: 2398 -YQDG--TLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVRE 2454
QDG +L I D G YT N G + ++ V+P G P I T+
Sbjct: 1341 FLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLY--VEPAAPLGAPTYIPTLEP 1398
Query: 2455 IAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSV 2514
++ R L P + PA R++ R L ++D
Sbjct: 1399 VSR--IRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPG-------RRLEETDES 1449
Query: 2515 QLVCMARNEGGEARLILQLTVLEPMEKPIF-HDPISEKITAMAGHTISLNCSAAGTPTPS 2573
Q LE + KP+F P+S K + G T + G P P
Sbjct: 1450 Q--------------------LERLYKPVFVLKPVSFK--CLEGQTARFDLKVVGRPMPE 1487
Query: 2574 LVWVLPNGTDLQSGQQLQRFYH-----KADG--MLHISGLSSVDAGAYRCVARNAAGHTE 2626
W GQQ+ Y K DG L I + D+G + VA+N AG +
Sbjct: 1488 TFW-------FHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSS 1540
Query: 2627 RLVSLKV-----GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSW 2671
V L V +KP ++ N V+I G L++ G W
Sbjct: 1541 ISVILTVEAVEHQVKPMFVEKLKN-VNIKEGSRLEMKVRATGNPNPDIVW 1589
Score = 68.6 bits (166), Expect = 9e-11
Identities = 199/882 (22%), Positives = 342/882 (38%), Gaps = 118/882 (13%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
E P I V V + + F CE + +PK F W K + T RFE++K+
Sbjct: 11837 ELPLIFITPLSDVKVFEKDEAKFECEVSREPKTF-RWLKGTQEI-----TGDDRFELIKD 11890
Query: 1911 GT---LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDT 1967
GT +VI+ +D +YM A + H ++++ + ++ + +DVT ++
Sbjct: 11891 GTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIE-GIRLK----FLTPLKDVTAKEKES 11945
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPV---EGRITLHENRTLSIKEASFSDRGVYK 2024
A+ + ++ W D+R+ T S EG+ +++ K+ S D +
Sbjct: 11946 -AVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGK-----THSITFKDLSIDDTSQIR 11999
Query: 2025 CVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLG 2084
A G S A +L V P KL++ + + + C A P V+W
Sbjct: 12000 V---EAMGMSSEA-KLTVLEGDPYF-TGKLQDYTGVEKDEVILQCEISKADAP-VKW-FK 12052
Query: 2085 DGTQIRPSQFLHGNLFVFPNGT---LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQR 2141
DG +I+PS+ N + +G L ++ D G+Y C G+ + + +L+++
Sbjct: 12053 DGKEIKPSK----NAVIKADGKKRMLILKKALKSDIGQYTCDC----GTDKTSGKLDIE- 12103
Query: 2142 AAANARITGTSPRRT-DVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV 2200
+ I P + +V T + + S D W+L + ++ D IK
Sbjct: 12104 ---DREIKLVRPLHSVEVMETETARFETEISEDDI-HANWKLKGEALLQTP---DCEIKE 12156
Query: 2201 FAN-GTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVV--MKPAKIEHKEENDHKVFY 2257
+LV+ + G A N ++ +K V+ ++P K D V
Sbjct: 12157 EGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLK-------DVTVTA 12209
Query: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
G DC + P + W L L S S G+ TL +V +
Sbjct: 12210 GETATFDCELSYEDIP-VEWYLKGKKLEPSDKVVPRSEGKVH--------TLTLRDVKLE 12260
Query: 2318 EEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPK 2377
+ G+ A++ + V+ V + ++T V G + CE E K
Sbjct: 12261 DAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQT-----VEEGATAVLECEVSRENA-K 12314
Query: 2378 VTWLSPTNKVIPTSSEKYQIYQDGT---LLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIH 2434
V W +++ S+KY+I DG L+I D YTC +D KT +
Sbjct: 12315 VKWFKNGTEIL--KSKKYEIVADGRVRKLVIHDCTPEDIKTYTC-----DAKDFKTS-CN 12366
Query: 2435 VNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNR 2494
+NV PP + P+T ++ +R + E +V W F +G + G +
Sbjct: 12367 LNVVPPHVEFL-RPLTDLQVREKEMARFECELSRENA---KVKW-FKDGAEIKK---GKK 12418
Query: 2495 ITVHGNGSLDIRSLRK---SDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEK 2551
+ G++ I + K D + C R AR LTVLE E+ +F ++
Sbjct: 12419 YDIISKGAVRILVINKCLLDDEAEYSCEVRT----ARTSGMLTVLE--EEAVFTKNLAN- 12471
Query: 2552 ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADG---MLHISGLSS 2608
I TI L C + P ++W + +++G R+ +G +L I
Sbjct: 12472 IEVSETDTIKLVCEVS-KPGAEVIWYKGDEEIIETG----RYEILTEGRKRILVIQNAHL 12526
Query: 2609 VDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGR 2668
DAG Y C R + T+ V + L E + NL I+ GE + C+
Sbjct: 12527 EDAGNYNC--RLPSSRTDGKVKVHE-LAAEFISKPQNL-EILEGEKAEFVCSI-SKESFP 12581
Query: 2669 FSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYV 2710
W + LE ++ L V++A++ D GTYV
Sbjct: 12582 VQWKRDDKT-LESGDKYDVIADGKKRVLVVKDATLQDMGTYV 12622
Score = 66.2 bits (160), Expect = 4e-10
Identities = 60/201 (29%), Positives = 91/201 (45%), Gaps = 12/201 (5%)
Query: 1945 VTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITL 2004
+T Q P Q V V G T E G P P++SW F D +V T + +I+
Sbjct: 1 MTTQAPTF-TQPLQSVVVLEGSTATFEAHISGFPVPEVSW-FRDGQVISTSTLPGVQISF 58
Query: 2005 HENRT-LSIKEASFSDRGVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPG 2062
+ R L+I + ++ G Y A+N +G A S A L A P ++L+++++ G
Sbjct: 59 SDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQG 118
Query: 2063 LSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLY---IRNLAPKDSGR 2119
+ + P P V++ DG +I+ S + + G LY I P+DSG
Sbjct: 119 SQVRLQVRVTGIPTPVVKFYR-DGAEIQSSL----DFQISQEGDLYSLLIAEAYPEDSGT 173
Query: 2120 YECVAANLVGSARRTVQLNVQ 2140
Y A N VG A T +L VQ
Sbjct: 174 YSVNATNSVGRATSTAELLVQ 194
Score = 65.9 bits (159), Expect = 6e-10
Identities = 177/914 (19%), Positives = 303/914 (33%), Gaps = 208/914 (22%)
Query: 2053 KLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNG--TLYIR 2110
++ + +P G + ++ P V+W +G +++ S +H + +G TL I
Sbjct: 32379 RMRSHRVPCGQNTRFILNVQSKPTAEVKWY-HNGVELQESSKIH---YTNTSGVLTLEIL 32434
Query: 2111 NLAPKDSGRYECVAANLVGSARRTVQLNVQ----RAAANARITGTSPR-------RTDVR 2159
+ DSG Y V N G A L+V A+ R PR RT+
Sbjct: 32435 DCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAY 32494
Query: 2160 YGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFD-SRIKVFANGTLVVKSVTDKDAGD 2218
+ K R + + ++L S++ S + L KS+ +K
Sbjct: 32495 AVSSFKKTSEMEASSSVREV-KSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTR 32553
Query: 2219 YLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWS 2278
+ L ++ KP + V+ G + C G P P ++W
Sbjct: 32554 KI----------KTTLAARILTKPRSMT--------VYEGESARFSCDTDGEPVPTVTW- 32594
Query: 2279 LPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEM--- 2335
L G ++++ + + T +Y T + V +EG+Y+ EN GK E
Sbjct: 32595 LRKGQVLSTSARHQVT---TTKY----KSTFEISSVQASDEGNYSVVVENSEGKQEAEFT 32647
Query: 2336 ------RVRVKVVTAPATIRNKT------------------------------------- 2352
RV K VT+P +++
Sbjct: 32648 LTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTE 32707
Query: 2353 ---YLAVQVP-----------YGDVVTVACEAKGEPM--PKVTWLSPTNKVIPTSSEKYQ 2396
+L V P ++ + C + + +VTW K+ ++
Sbjct: 32708 KVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH 32767
Query: 2397 IYQDGT--LLIQKAQRSDSGNYTCLVRNSAGEDRKTVW--------IHVNVQ-------- 2438
DGT L I SD G Y C + G + + IH V
Sbjct: 32768 YSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKS 32827
Query: 2439 -----------------PPKINGNPNPITTVREIAAGG-SRKLIDCKAEGIPTPRVLWAF 2480
P I+ P +T +++ S KA G P P +W
Sbjct: 32828 DQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTK 32887
Query: 2481 PEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV----- 2535
+ Y G L+I SDS C +N G +LT+
Sbjct: 32888 DGKAITQGGKY-KLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKD 32946
Query: 2536 -------------LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGT 2582
+ P +K + + IS+K A+ I ++
Sbjct: 32947 TEAQKVSTQKTSEITPQKKAVVQEEISQK--ALRSEEIKMS------------------- 32985
Query: 2583 DLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQ 2642
+ +S ++L + ++ S + + T + S +V E K
Sbjct: 32986 EAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQ-ASEEVRTHAEI-KA 33043
Query: 2643 YHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREAS 2702
+ +SI G+ L L GA + W L NG+ L + + TLT+++AS
Sbjct: 33044 FSTQMSINEGQRLVLKANIAGATDVK--WVL-NGVELTNSEEYRYGVSGSDQTLTIKQAS 33100
Query: 2703 VFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSE--PTPVIYTRP-------GNTVKL 2753
D G C +T+ G ++ Y ++ E P ++P G V
Sbjct: 33101 HRDEGILTCISKTKEG-------IVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLF 33153
Query: 2754 NCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAK 2813
C G P +I W K++L + + + +R + SL I++A+ D+G Y AK
Sbjct: 33154 TCEISGEPSPEIEWF---KNNLPISISSNVSISRSRNVY-SLEIRNASVSDSGKYTIKAK 33209
Query: 2814 NILGSDSKTTYIHV 2827
N G S T + V
Sbjct: 33210 NFRGQCSATASLMV 33223
Score = 64.7 bits (156), Expect = 1e-09
Identities = 186/957 (19%), Positives = 320/957 (33%), Gaps = 124/957 (12%)
Query: 1845 KFWSLGEKPQILTKSPQTV------SVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTP 1898
K+ L ++P L +P+ V +T F KP V W G +
Sbjct: 32359 KYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKW--YHNGVELQE 32416
Query: 1899 NTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQ 1958
+++I TL I D G Y +N G L VT AS +
Sbjct: 32417 SSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRR 32476
Query: 1959 DVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFS 2018
D V ++ E A + +V V+ ++T +LS E S S
Sbjct: 32477 DEEV--PRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMT-ETRESLSSYEHSAS 32533
Query: 2019 DRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPS 2078
+ + S ++ ++ K ++++ G S C P+P+
Sbjct: 32534 AEMKSAALEEKSLEEKSTTRKIKTTLAARIL--TKPRSMTVYEGESARFSCDTDGEPVPT 32591
Query: 2079 VRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLN 2138
V W+ Q+ + H T I ++ D G Y V N G L
Sbjct: 32592 VTWLRKG--QVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLT 32649
Query: 2139 VQRAAANARITGTSPR--------RTDVRYGGTLKLDCSASGDP---WPRILWRLPSKRM 2187
+Q+A + + PR ++ ++ P P P++++
Sbjct: 32650 IQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKV 32709
Query: 2188 IDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEH 2247
S +I F +K+ K+ CV + VL+ V +
Sbjct: 32710 QHLPVSAPPKITQF------LKAEASKEIAKLTCVVESS------VLRAKEVTWYKDGKK 32757
Query: 2248 KEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG 2307
+EN H F+ A G +I+ +L + + GG +K + F
Sbjct: 32758 LKENGHFQFHYS-------ADGTYELKIN-NLTESDQGEYVCEISGEGGTSKTNLQFMGQ 32809
Query: 2308 TLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLA-----VQVPYGD 2362
F + + +Q + R AP I +K + V
Sbjct: 32810 A--FKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDS 32867
Query: 2363 VVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDG---TLLIQKAQRSDSGNYTCL 2419
V A +A GEP P W + T KY++ +D L I K SDSG YTC
Sbjct: 32868 VAKFAVKATGEPRPTAIWTKDGKAI--TQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCT 32925
Query: 2420 VRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWA 2479
V+NSAG + + T++ I ++K+ K I TP+
Sbjct: 32926 VKNSAGSVSSSCKL-----------------TIKAIKDTEAQKVSTQKTSEI-TPQKKAV 32967
Query: 2480 FPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLI---LQLTVL 2536
E + +L ++ S++ +A E LI ++ +
Sbjct: 32968 VQEEI--------------SQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAA 33013
Query: 2537 EPMEKPIFHDPI------SEKITAMA-------------GHTISLNCSAAGTPTPSLVWV 2577
+EK I H+ I SE++ A G + L + AG + WV
Sbjct: 33014 TSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAG--ATDVKWV 33071
Query: 2578 LPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAG----HTERLVSLKV 2633
L NG +L + ++ + +D L I S D G C+++ G + +S ++
Sbjct: 33072 L-NGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKEL 33130
Query: 2634 GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN 2693
P Q + +I G+ + C G W N + + + +
Sbjct: 33131 SDAPAFISQPRS-QNINEGQNVLFTCEISGEPSPEIEW-FKNNLPISISSNVSISRSRNV 33188
Query: 2694 GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNT 2750
+L +R ASV D G Y + + G + ++V+ P + V+ G+T
Sbjct: 33189 YSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL---PLVEEPSREVVLRTSGDT 33242
Score = 63.9 bits (154), Expect = 2e-09
Identities = 136/606 (22%), Positives = 220/606 (36%), Gaps = 101/606 (16%)
Query: 1852 KPQI--LTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLK 1909
KP++ L + + V+VTA F CE + + P + K G + P+ ++ K
Sbjct: 12192 KPRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLK---GKKLEPSDKVVPRSEGK 12248
Query: 1910 NGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIA 1969
TL +R V+++D G+ TA + + V + P +D TV G T
Sbjct: 12249 VHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVK-----EPPVEFTKPLEDQTVEEGATAV 12303
Query: 1970 MECLAKGTPAPQISWIFPDRRVWQTVS---PVEGRITLHENRTLSIKEASFSDRGVYKCV 2026
+EC A ++ W + ++ +GR+ R L I + + D Y C
Sbjct: 12304 LECEVSRENA-KVKWFKNGTEILKSKKYEIVADGRV-----RKLVIHDCTPEDIKTYTCD 12357
Query: 2027 ASNAAGADSL-AIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD 2085
A + + +L + HV L P L ++ + C V+W D
Sbjct: 12358 AKDFKTSCNLNVVPPHVEFLRP------LTDLQVREKEMARFECELSRENA-KVKW-FKD 12409
Query: 2086 GTQIRPSQFLHGNLFVFPNGT---LYIRNLAPKDSGRYECVAANLVGSARRTVQLNV--Q 2140
G +I+ + + G L I D Y C V +AR + L V +
Sbjct: 12410 GAEIKKGK----KYDIISKGAVRILVINKCLLDDEAEYSCE----VRTARTSGMLTVLEE 12461
Query: 2141 RAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV 2200
A + TD T+KL C S P ++W + +I+ R ++
Sbjct: 12462 EAVFTKNLANIEVSETD-----TIKLVCEVS-KPGAEVIWYKGDEEIIET-----GRYEI 12510
Query: 2201 FANGT---LVVKSVTDKDAGDYLCVARNKVGDDYVV---LKVDVVMKPAKIEHKEENDHK 2254
G LV+++ +DAG+Y C + D V L + + KP +E
Sbjct: 12511 LTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQNLE-------- 12562
Query: 2255 VFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEV 2314
+ G + C + P + W D +L + + G+ KR +V + TL
Sbjct: 12563 ILEGEKAEFVCSISKESFP-VQWKRDDKTLESGDKYDVIADGK-KRVLVVKDATL----- 12615
Query: 2315 GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDV-------VTVA 2367
++ G Y V V A A + L + VP D V
Sbjct: 12616 --QDMGTYV-------------VMVGAARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFN 12660
Query: 2368 CEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDG---TLLIQKAQRSDSGNYTCLVRNSA 2424
CE E K W + +S KY I Q TL I+ A D NY + N
Sbjct: 12661 CEVNTEGA-KAKWFRNEEAIFDSS--KYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHR 12717
Query: 2425 GEDRKT 2430
GE+ K+
Sbjct: 12718 GENVKS 12723
Score = 63.2 bits (152), Expect = 4e-09
Identities = 53/232 (22%), Positives = 93/232 (40%), Gaps = 13/232 (5%)
Query: 2319 EGDYTCFAENQVG-----KDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGE 2373
E ++ FAEN+ G + M ++ K+ + A K V G+ ++C+ G
Sbjct: 30500 EYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGR 30559
Query: 2374 PMPKVTWLSPTNKVIPTSSEKYQIYQDG---TLLIQKAQRSDSGNYTCLVRNSAGEDRKT 2430
P+P + W ++I S KY++ DG TL + ++ D G YTC+ N GE +
Sbjct: 30560 PLPDIKWYRFGKELI--QSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETS 30617
Query: 2431 VWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPY 2490
+ + P G P + A GS + G P P + W + ++ +
Sbjct: 30618 SKLLLQATPQFHPGYP---LKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSEN 30674
Query: 2491 YGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKP 2542
T H + RK+ + + N G IL + + + +KP
Sbjct: 30675 ITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKP 30726
Score = 63.2 bits (152), Expect = 4e-09
Identities = 78/313 (24%), Positives = 118/313 (37%), Gaps = 49/313 (15%)
Query: 2361 GDVVTVACEAKG-EPMPKVTWLSPTNKVIPTSSEKYQI-YQDGT--LLIQKAQRSDSGNY 2416
G V C+ + + +VTW ++ +SEKY+I Y+DG L ++ + D G Y
Sbjct: 31582 GGHVKYVCKIENYDQSTQVTWYFGVRQL--ENSEKYEITYEDGVAILYVKDITKLDDGTY 31639
Query: 2417 TCLVRNSAGED---------------------------RKTVWIHVNVQPPKINGNPNPI 2449
C V N GED R+T + + +PP+ +
Sbjct: 31640 RCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFT-----L 31694
Query: 2450 TTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVH---GNGSLDIR 2506
+ A G P P V W + G + + T G L I
Sbjct: 31695 PLYNKTAYVGENVRFGVTITVHPEPHVTW-YKSGQKIKPGDNDKKYTFESDKGLYQLTIN 31753
Query: 2507 SLRKSDSVQLVCMARNEGGEARLILQLTV-LEPMEKPIFHDPISEKITAMA----GHTIS 2561
S+ D + +ARN+ GE +LTV L P P+ +++ A A G ++
Sbjct: 31754 SVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVC 31813
Query: 2562 LNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM-LHISGLSSVDAGAYRCVARN 2620
+G P P+L W +G L G ++ + D LHI D G YR A N
Sbjct: 31814 FEIRVSGIPPPTLKWE-KDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATN 31872
Query: 2621 AAGHTERLVSLKV 2633
AG T L+V
Sbjct: 31873 TAGSTSCQAHLQV 31885
Score = 60.8 bits (146), Expect = 2e-08
Identities = 56/202 (27%), Positives = 89/202 (44%), Gaps = 13/202 (6%)
Query: 478 MIEPSGAVQRDQT--VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSIL 535
++EP+ V++ ++ V G C L C V + S W DG L + S F+ +
Sbjct: 7582 VLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKW-FKDGKELTSDNKYKISFFNKV 7640
Query: 536 SSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPA--EKDTVTIGKNPGE 593
S L+I ++ PSDSG+Y Q D + V + P+ K T G + G
Sbjct: 7641 SG--LKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLS-GS 7697
Query: 594 SVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGT--LSIPKVQVSDSGYYRC 651
SV + C P +SW I + + L + T L++ ++ SDSG Y C
Sbjct: 7698 SVVMECKVYGSPPISVSWFHEGNEISS---GRKYQTTLTDNTCALTVNMLEESDSGDYTC 7754
Query: 652 VAVNQQGADHFTVGITVTKKGS 673
+A N G+D + +TV + S
Sbjct: 7755 IATNMAGSDECSAPLTVREPPS 7776
Score = 58.9 bits (141), Expect = 7e-08
Identities = 135/693 (19%), Positives = 242/693 (34%), Gaps = 109/693 (15%)
Query: 2202 ANGT--LVVKSVTDKDAGDYLCVARNKVGDDYVVLKV------DVVMKPAKIEHKEENDH 2253
A+GT L + ++T+ D G+Y+C + G L+ + K +KI +++D
Sbjct: 32770 ADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQ 32829
Query: 2254 K--------------------------------VFYGGDLKVDCVATGLPNPEISWSLPD 2281
K V K ATG P P W+ D
Sbjct: 32830 KTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWT-KD 32888
Query: 2282 GSLVNS---FMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVR 2338
G + + S+D GG L ++ + G YTC +N G +
Sbjct: 32889 GKAITQGGKYKLSEDKGGFF----------LEIHKTDTSDSGLYTCTVKNSAGSVSSSCK 32938
Query: 2339 VKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIY 2398
+ + T K V + + K +++ + ++ I S K Q
Sbjct: 32939 LTIKAIKDTEAQK------VSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQ-- 32990
Query: 2399 QDGTLLIQKAQRSDSGNYTCL---VRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREI 2455
+K + + + V+ SA + +H + K + + T EI
Sbjct: 32991 -------EKLALKEEASKVLISEEVKKSAATSLEKSIVHEEIT--KTSQASEEVRTHAEI 33041
Query: 2456 AAGGSRKLID------CKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNG-SLDIRSL 2508
A ++ I+ KA V W + + Y R V G+ +L I+
Sbjct: 33042 KAFSTQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEY--RYGVSGSDQTLTIKQA 33099
Query: 2509 RKSDSVQLVCMARNEGGEARLILQLTVLEPM-EKPIF-HDPISEKITAMAGHTISLNCSA 2566
D L C+++ + G + LT+ + + + P F P S+ I G + C
Sbjct: 33100 SHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINE--GQNVLFTCEI 33157
Query: 2567 AGTPTPSLVWVLPN-GTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHT 2625
+G P+P + W N + S + R + L I S D+G Y A+N G
Sbjct: 33158 SGEPSPEIEWFKNNLPISISSNVSISRSRNVYS--LEIRNASVSDSGKYTIKAKNFRGQC 33215
Query: 2626 ERLVSLKV-GLKPEANKQY-------HNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGM 2677
SL V L E +++ +L + +++++ + A FS + + M
Sbjct: 33216 SATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSM 33275
Query: 2678 HLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITS 2737
++ S+ V +S G + M + + + PP+I +
Sbjct: 33276 TEMKFASMSAQSMSSMQESFVEMSSSSFMG--ISNMTQLESSTSKMLKAGIRGIPPKIEA 33333
Query: 2738 EPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLT- 2796
P+ + G + + C G P ++TW + + ++ G + LT
Sbjct: 33334 LPSDISIDE-GKVLTVACAFTGEPTPEVTWSCGGRK-----IHSQEQGRFHIENTDDLTT 33387
Query: 2797 --IQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
I ++D G Y N GSDS T IH+
Sbjct: 33388 LIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420
Score = 57.4 bits (137), Expect = 2e-07
Identities = 59/269 (21%), Positives = 97/269 (36%), Gaps = 47/269 (17%)
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVT-------------------------- 1946
L ++ + D G Y C N +G D L V
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRL 31685
Query: 1947 VQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEG--RITL 2004
+++P + T Y+G+ + P P ++W + Q + P + + T
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWY----KSGQKIKPGDNDKKYTF 31741
Query: 2005 HENR---TLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPV-------IHQEKL 2054
++ L+I + D Y VA N G DS +L V PP + + L
Sbjct: 31742 ESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLL 31801
Query: 2055 ENISLPPGLSIHIHCTAKAAPLPSVRWVL-GDGTQIRPS-QFLHGNLFVFPNGTLYIRNL 2112
N G S+ P P+++W G + P+ + +H L + L+IR+
Sbjct: 31802 ANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYY---ALHIRDT 31858
Query: 2113 APKDSGRYECVAANLVGSARRTVQLNVQR 2141
P+D+G Y A N GS L V+R
Sbjct: 31859 LPEDTGYYRVTATNTAGSTSCQAHLQVER 31887
Score = 56.6 bits (135), Expect = 3e-07
Identities = 60/210 (28%), Positives = 87/210 (41%), Gaps = 27/210 (12%)
Query: 477 VMIEPSGAVQR--DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSI 534
+++EP+ V++ TV G C L C V + S+ W DG +L + S ++
Sbjct: 5699 MVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWY-KDGKLLTSSQKHKFSFYNK 5757
Query: 535 LSSGWLRIKSMEPSDSGLY-----------QCIAQVRDEMDRMVYRVLVQSPSTQPAEKD 583
+SS LRI S+E D+G Y C A V D DR V PS K+
Sbjct: 5758 ISS--LRILSVERQDAGTYTFQVQNNVGKSSCTAVV-DVSDRAV------PPSFTRRLKN 5808
Query: 584 TVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQV 643
T G G S L C ++W +I++ A + TL + +
Sbjct: 5809 T---GGVLGASCILECKVAGSSPISVAWFHEKTKIVSG-AKYQTTFSDNVCTLQLNSLDS 5864
Query: 644 SDSGYYRCVAVNQQGADHFTVGITVTKKGS 673
SD G Y CVA N G+D +TV + S
Sbjct: 5865 SDMGNYTCVAANVAGSDECRAVLTVQEPPS 5894
Score = 56.6 bits (135), Expect = 3e-07
Identities = 46/175 (26%), Positives = 67/175 (38%), Gaps = 17/175 (9%)
Query: 2315 GMREEGDYTCFAENQVGK---DEMRVRVKVVTAPATIRNKT-YLAVQVPYGDVVTVACEA 2370
G+RE DY C + K D MR+ + + NKT Y+ V +G +TV
Sbjct: 31660 GVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITV---- 31715
Query: 2371 KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGT----LLIQKAQRSDSGNYTCLVRNSAGE 2426
P P VTW K+ P ++K ++ L I D YT + RN GE
Sbjct: 31716 --HPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGE 31773
Query: 2427 DRKTVWIHVNVQPPKINGNPNPI---TTVREIAAGGSRKLIDCKAEGIPTPRVLW 2478
D + V + PP + P+ G + + GIP P + W
Sbjct: 31774 DSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKW 31828
Score = 56.6 bits (135), Expect = 3e-07
Identities = 65/304 (21%), Positives = 120/304 (39%), Gaps = 24/304 (7%)
Query: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVL 1908
L + P +++ P++ ++ + +F CE +G+P P + W K + ++ N I R +
Sbjct: 33130 LSDAPAFISQ-PRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNV 33188
Query: 1909 KNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTI 1968
+ L IR V D G+Y A N G L V P + + V GDT
Sbjct: 33189 YS--LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL---PLVEEPSREVVLRTSGDTS 33243
Query: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS 2028
+ + + Q+S + S +T + ++S + S + +S
Sbjct: 33244 LQGSFS--SQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSS 33301
Query: 2029 NAAGADSLA---------IRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
+ G ++ ++ + +PP I + +IS+ G + + C P P V
Sbjct: 33302 SFMGISNMTQLESSTSKMLKAGIRGIPPKI-EALPSDISIDEGKVLTVACAFTGEPTPEV 33360
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNG---TLYIRNLAPKDSGRYECVAANLVGSARRTVQ 2136
W G G +I + G + TL I ++ +D G Y N GS TV
Sbjct: 33361 TWSCG-GRKIHSQE--QGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVN 33417
Query: 2137 LNVQ 2140
++++
Sbjct: 33418 IHIR 33421
Score = 55.8 bits (133), Expect = 6e-07
Identities = 50/181 (27%), Positives = 73/181 (40%), Gaps = 17/181 (9%)
Query: 499 LSCNVKASESPSIFWV-----LPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLY 553
L C V ++ W LP G K +D K + L ++K DSG Y
Sbjct: 3663 LECQVDEDRKVTVTWSKDGQKLPPGKDYKICFED---KIATLEIPLAKLK-----DSGTY 3714
Query: 554 QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWIL 613
C A V V+ P + + D + PGES L C P ++W
Sbjct: 3715 VCTASNEAGSSSCSATVTVREPPSFVKKVDPSYL-MLPGESARLHCKLKGSPVIQVTWFK 3773
Query: 614 PNRRIINDLANTSHVYMLPN-GTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKG 672
N+ + +NT +Y + + L I V+V DSG Y C AVN G+D + I + +
Sbjct: 3774 NNKELSE--SNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPP 3831
Query: 673 S 673
S
Sbjct: 3832 S 3832
Score = 55.8 bits (133), Expect = 6e-07
Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 8/183 (4%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
+D + G L C V S S+ W I+ P ++ + L + +E
Sbjct: 6748 KDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCT---LNLSLLE 6804
Query: 547 PSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPE 606
PSD+G+Y C+A D + VQ P + D+V + PG S+T P
Sbjct: 6805 PSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEV--LPGMSLTFTSVIRGTPP 6862
Query: 607 AHLSWILPNRRII-NDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVG 665
+ W +R ++ + N S + L + +VQ +SG Y C+ N G+ T
Sbjct: 6863 FKVKWFKGSRELVPGESCNISLEDFVTE--LELFEVQPLESGDYSCLVTNDAGSASCTTH 6920
Query: 666 ITV 668
+ V
Sbjct: 6921 LFV 6923
Score = 55.5 bits (132), Expect = 8e-07
Identities = 173/834 (20%), Positives = 284/834 (34%), Gaps = 133/834 (15%)
Query: 1879 GKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDR 1938
G+P P VTW KV ++ ++ + + LVI D G+Y T N G
Sbjct: 18632 GRPAPKVTWRKVGIDNVVRKG-QVDLVDTM--AFLVIPNSTRDDSGKYSLTLVNPAGEKA 18688
Query: 1939 MVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTP-----APQISWIF-----PD 1988
+ V + V + DVT C P Q++ D
Sbjct: 18689 VFVNVRVLDTPGPVSDLKVSDVT-------KTSCHVSWAPPENDGGSQVTHYIVEKREAD 18741
Query: 1989 RRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPV 2048
R+ W TV+P + + H + E F + A N G + PV
Sbjct: 18742 RKTWSTVTPEVKKTSFHVTNLVPGNEYYF------RVTAVNEYGPG-----VPTDVPKPV 18790
Query: 2049 IHQEKLENISLPPGLSIH--IHCTAKAAPLPSVR--------WVLGDGTQIRPSQFLHGN 2098
+ + L P L + +A A LP +R ++ + +P+
Sbjct: 18791 LASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPAD-RWTE 18849
Query: 2099 LFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGT-SPRRTD 2157
V + +L + L ++ A N VG + V A P +
Sbjct: 18850 YSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQIT 18909
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAG 2217
++ G L+++ G P P W+ ++ + S + K ++ L++K VT KD+G
Sbjct: 18910 IKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTS--SHLAVHKADSSSILIIKDVTRKDSG 18967
Query: 2218 DYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISW 2277
Y A N G D +KV V+ P F D+ D + +SW
Sbjct: 18968 YYSLTAENSSGTDTQKIKVVVMDAPGP-------PQPPFDISDIDADACS-------LSW 19013
Query: 2278 SLP---DGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCF---AENQVG 2331
+P GS + +++ R + T VG G F AEN+ G
Sbjct: 19014 HIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFG 19073
Query: 2332 KDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPK-------VTWLSP- 2383
E K+V Q P+G V E K + K V W P
Sbjct: 19074 ISEPLTSPKMV-------------AQFPFG----VPSEPKNARVTKVNKDCIFVAWDRPD 19116
Query: 2384 TNKVIPTSSEKYQIYQDGTLLIQKAQRS--DSGNYTC-------------LVRNSAG--- 2425
++ P + + +LL KA + S Y C N AG
Sbjct: 19117 SDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSP 19176
Query: 2426 --EDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEG 2483
+ + V + V PP G P I + + LI + + +++ F E
Sbjct: 19177 PSKPTEYVTARMPVDPP---GKPEVIDVTKSTVS-----LIWARPKHDGGSKIIGYFVEA 19228
Query: 2484 VVLPAPYYGNRITVH---GNGSLDIRSLRKSDSVQLVCMAR---NEGGEARLILQLTVLE 2537
LP + T L + Q +AR N + +T+L
Sbjct: 19229 CKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILA 19288
Query: 2538 PMEKPIFHDPISEK--ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYH 2595
P ++ K +T AG + L+ + G P P++ W +GT L+ + ++
Sbjct: 19289 ENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSW-KKDGTLLKPAEGIKMAMQ 19347
Query: 2596 KADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP------EANKQY 2643
+ L + ++ D+G Y A N++G + LKV KP + NK Y
Sbjct: 19348 RNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMY 19401
Score = 55.1 bits (131), Expect = 1e-06
Identities = 55/199 (27%), Positives = 79/199 (39%), Gaps = 31/199 (15%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSIL-SSGWLRIKSM 545
RD G P C + SE S+ W DG LK D P+ + S L ++ L I
Sbjct: 8064 RDVQETVGLPVVFDCAISGSEPISVSWY-KDGKPLK---DSPNVQTSFLDNTATLNIFKT 8119
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQP------AEKDTVTIGKNPGESVTLPC 599
+ S +G Y C A R+++ P A D V GES C
Sbjct: 8120 DRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV-----GESADFEC 8174
Query: 600 NALAIPEAHLSWILPNRRI-------INDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCV 652
+ +SW +R I I+ L N++H L++ KV DSG Y C
Sbjct: 8175 HVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAH--------LTVLKVDKGDSGQYTCY 8226
Query: 653 AVNQQGADHFTVGITVTKK 671
AVN+ G D T + + ++
Sbjct: 8227 AVNEVGKDSCTAQLNIKER 8245
Score = 54.3 bits (129), Expect = 2e-06
Identities = 51/226 (22%), Positives = 91/226 (40%), Gaps = 17/226 (7%)
Query: 1925 QYMCTASNLHGLDR-----MVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPA 1979
++ A N GL R M + +T + + +DVT LG+ + C G P
Sbjct: 30502 EFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPL 30561
Query: 1980 PQISWIFPDRRVWQT---VSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSL 2036
P I W + + Q+ +GR TL++ D GVY C+A+N G
Sbjct: 30562 PDIKWYRFGKELIQSRKYKMSSDGR-----THTLTVMTEEQEDEGVYTCIATNEVGEVET 30616
Query: 2037 AIRLHVAALPPVIHQEKL-ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFL 2095
+ +L + A P L E G ++ +H P+P++ W G
Sbjct: 30617 SSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENIT 30676
Query: 2096 HGNLFVFPNGTLYIRNLAPK-DSGRYECVAANLVGSARRTVQLNVQ 2140
N + + L ++N+ K +G+Y+ +N+ G+ + + +Q
Sbjct: 30677 IENTEHYTH--LVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQ 30720
Score = 53.5 bits (127), Expect = 3e-06
Identities = 43/186 (23%), Positives = 77/186 (41%), Gaps = 9/186 (4%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG--WLRIKSM 545
D + + G QL ++ +E S+ W G I++ + D+ + S L+ +
Sbjct: 7500 DISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVR----ESDNIWISYSENIATLQFSRV 7555
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP 605
EP+++G Y C + M + V P+T + +++ + G++ TL C P
Sbjct: 7556 EPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKV--TTGDTCTLECTVAGTP 7613
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVG 665
E W + + +D + +G L I V SDSG Y N G D T
Sbjct: 7614 ELSTKWFKDGKELTSDNKYKISFFNKVSG-LKIINVAPSDSGVYSFEVQNPVGKDSCTAS 7672
Query: 666 ITVTKK 671
+ V+ +
Sbjct: 7673 LQVSDR 7678
Score = 52.8 bits (125), Expect = 5e-06
Identities = 169/864 (19%), Positives = 297/864 (34%), Gaps = 126/864 (14%)
Query: 2009 TLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIH 2068
+L IK + D VY G + RLHV + + +K ++++ ++
Sbjct: 2763 SLRIKNCAIVDESVY----GFRLGRLGASARLHVETVKII---KKPKDVTALENATVAFE 2815
Query: 2069 CTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLV 2128
+ +P V+W +I+PS H + L ++N++P D+G Y V L
Sbjct: 2816 VSVSHDTVP-VKW-FHKSVEIKPSD-KHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLE 2872
Query: 2129 GSARRTVQ-LNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRM 2187
A+ V+ L++ + N + T T +C S + +PS +
Sbjct: 2873 CKAKLFVETLHITKTMKNIEVPETK----------TASFECEVSH-------FNVPSMWL 2915
Query: 2188 IDAL-FSFDSRIKVFANG---TLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPA 2243
+ + + K+ G L++ + + +D+ +Y V N + + ++
Sbjct: 2916 KNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTPIMITSML 2975
Query: 2244 KIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVV 2303
K + EE D F V W L +G + S +D RTK+
Sbjct: 2976 KDINAEEKDTITFE--------VTVNYEGISYKW-LKNGVEIKS---TDKCQMRTKKL-- 3021
Query: 2304 FNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDV 2363
+L V + DYT A + V + + I++ ++V
Sbjct: 3022 --THSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHIKD-----IKVLEKKR 3074
Query: 2364 VTVACEAKGEPMPKVTWLSPTNKV-----IPTSSEKYQIYQDGTLLIQKAQRSDSGNYTC 2418
CE EP V W+ ++ I EKY LLI + SD+G YT
Sbjct: 3075 AMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEKYV----HRLLIPSTRMSDAGKYTV 3129
Query: 2419 LVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLW 2478
+ AG + T + V + +I + + + R +++ + W
Sbjct: 3130 V----AGGNVSTAKLFVEGRDVRIRSIKKEVQVIEK-----QRAVVEFEVNEDDVD-AHW 3179
Query: 2479 AFPEGV-----VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQL 2533
+ +G+ V Y +H + I R+SD+ + +A G R + L
Sbjct: 3180 -YKDGIEINFQVQERHKYVVERRIH---RMFISETRQSDAGEYTFVA----GRNRSSVTL 3231
Query: 2534 TVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRF 2593
V P + + + +T +G +G P P + W L +G + +
Sbjct: 3232 YVNAPEPPQVLQE--LQPVTVQSGKPARFCAVISGRPQPKISWYKEEQL-LSTGFKCKFL 3288
Query: 2594 YHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLV---SII 2650
+ + L + DA Y C A+N G SL V + + V +II
Sbjct: 3289 HDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAII 3348
Query: 2651 ---------NGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREA 2701
G+ + C G + SW ++ + D L + EA
Sbjct: 3349 TPLQDTVTSEGQPARFQCRVSGTDL-KVSW-YSKDKKIKPSRFFRMTQFEDTYQLEIAEA 3406
Query: 2702 SVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSE-----------PTPVIYTR---- 2746
D GTY G V+S + + P I E PVI +
Sbjct: 3407 YPEDEGTYTFVASNAVG-QVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPL 3465
Query: 2747 ---PGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQR 2803
G+ K C P W + ++ + + ++++ SL I
Sbjct: 3466 EVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESD-KCSIRSSKYI---SSLEILRTQVV 3521
Query: 2804 DAGFYKCMAKNILGSDSKTTYIHV 2827
D G Y C A N GS S T + V
Sbjct: 3522 DCGEYTCKASNEYGSVSCTATLTV 3545
Score = 52.8 bits (125), Expect = 5e-06
Identities = 52/190 (27%), Positives = 78/190 (41%), Gaps = 23/190 (12%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSS-GWLRIKSME 546
+QTV G P L+C + S + W DG +L+ DD + + S + + L+I +
Sbjct: 6185 EQTV--GLPVTLTCRLNGSAPIQVCWYR-DGVLLR---DDENLQTSFVDNVATLKILQTD 6238
Query: 547 PSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPA-EKDTVTIGKNPGESVTLPCNALAIP 605
S SG Y C A R+ + P P + V+I GES C+
Sbjct: 6239 LSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQ 6298
Query: 606 EAHLSWILPNRRI-------INDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
++W N+ I I + NT H+ +L KV DSG Y C A N G
Sbjct: 6299 PMRITWSKDNKEIRPGGNYTITCVGNTPHLRIL--------KVGKGDSGQYTCQATNDVG 6350
Query: 659 ADHFTVGITV 668
D + ++V
Sbjct: 6351 KDMCSAQLSV 6360
Score = 52.8 bits (125), Expect = 5e-06
Identities = 121/544 (22%), Positives = 179/544 (32%), Gaps = 105/544 (19%)
Query: 2141 RAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKV 2200
+A +AR+ G +R G L LD + G P P+I+W K + L S
Sbjct: 29045 KAELDARLHGDL---VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL--DLCEKVSLQYT 29099
Query: 2201 FANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGD 2260
T V+K D+G Y +N G V + V V+ P G
Sbjct: 29100 GKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSPGPC-------------GK 29146
Query: 2261 LKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEG 2320
L V V ++WSLP +D G Y+V T N V + E
Sbjct: 29147 LTVSRVTQ--EKCTLAWSLP----------QEDGGAEITHYIVERRETSRLNWVIVEGEC 29194
Query: 2321 DYTCFAENQVGK-DEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVT 2379
+ ++ K +E RV+ V NK YG V V E P V
Sbjct: 29195 PTLSYVVTRLIKNNEYIFRVRAV-------NK--------YGPGVPVESE------PIVA 29233
Query: 2380 WLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQ- 2438
S T P E+ ++ ++ SD GN E + W VN
Sbjct: 29234 RNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDY 29293
Query: 2439 ---------PPKINGNPNPITTVREIAAGGSR-----KLIDCK----AEGIPT-PRVLWA 2479
+ G AAG S I C+ G P+ PRV+
Sbjct: 29294 VVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDT 29353
Query: 2480 FPEGVVL--PAPYYGNRITVHG-----------------------NGSLDIRSLRKSDSV 2514
+ L P Y + G N + L+
Sbjct: 29354 TKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKY 29413
Query: 2515 QLVCMARNEGGEARLILQLTVLEPMEK---PIFH--DPISEKITAMAGHTISLNCSAAGT 2569
A N G + + +EP+E+ P D + + +T AG ++ L S +G
Sbjct: 29414 SFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGR 29473
Query: 2570 PTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLV 2629
P P + W G DL S + ++ +L + ++ DAG Y A N +G V
Sbjct: 29474 PPPVITW-SKQGIDLASRAIIDT--TESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATV 29530
Query: 2630 SLKV 2633
+KV
Sbjct: 29531 LVKV 29534
Score = 52.8 bits (125), Expect = 5e-06
Identities = 48/204 (23%), Positives = 79/204 (38%), Gaps = 19/204 (9%)
Query: 2248 KEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG 2307
KE D G ++ C G P P+I W L+ S S GRT V
Sbjct: 30537 KEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTE- 30595
Query: 2308 TLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPA-----TIRNKTYLAVQVPYGD 2362
+EG YTC A N+VG+ E ++ + P ++ K Y AV G
Sbjct: 30596 -------EQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAV----GS 30644
Query: 2363 VVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQK--AQRSDSGNYTCLV 2420
+ + G P+P +TW + + + + + T L+ K +++ +G Y +
Sbjct: 30645 TLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQL 30704
Query: 2421 RNSAGEDRKTVWIHVNVQPPKING 2444
N G + + + +P K G
Sbjct: 30705 SNVFGTVDAILDVEIQDKPDKPTG 30728
Score = 52.4 bits (124), Expect = 6e-06
Identities = 57/212 (26%), Positives = 87/212 (41%), Gaps = 42/212 (19%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEAT--GKPKPFVTW----------------TKVST 1892
+K T S Q ++ + + TV P E +P P + K
Sbjct: 843 QKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQFPFADTPDTYKSEAGVEVKKEV 902
Query: 1893 GALMTPNT-RIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQ 1951
G +T T R +RFEVL R+ +V + + V + VT P
Sbjct: 903 GVSITGTTVREERFEVLHG-----REAKVTETARVPAP-----------VEIPVT---PP 943
Query: 1952 ILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHEN-RTL 2010
L S ++VTV G+++ +EC G P+P ++W R +Q S ++ +IT L
Sbjct: 944 TLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY---REDYQIESSIDFQITFQSGIARL 1000
Query: 2011 SIKEASFSDRGVYKCVASNAAGADSLAIRLHV 2042
I+EA D G + C A N AG S + L V
Sbjct: 1001 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 1032
Score = 52.0 bits (123), Expect = 8e-06
Identities = 121/590 (20%), Positives = 208/590 (35%), Gaps = 106/590 (17%)
Query: 2054 LENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLA 2113
L+++++ G + C + SV+W L D QI+P + + L I
Sbjct: 2451 LKDVNVIEGTKAVLECKVSVPDVTSVKWYLND-EQIKPDDRVQA-IVKGTKQRLVINRTH 2508
Query: 2114 PKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGD 2173
D G Y+ + VG L+V++ I G +++ S SG
Sbjct: 2509 ASDEGPYKLI----VGRVETNCNLSVEKIKI---IRGLRDLTCTETQNVVFEVELSHSGI 2561
Query: 2174 PWPRILWRLPSKRMIDALFSFDSRIKVFANG---TLVVKSVTDKDAGDYLCVARNKVGDD 2230
+LW K + + S+ K+ A+G L V ++ D G Y A +
Sbjct: 2562 D---VLWNFKDKEIKPS-----SKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSG 2613
Query: 2231 YVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGS---LVNS 2287
+ + + KP + E+ VF +C P+ + W L DG L N+
Sbjct: 2614 KLTVAGGAISKPLTDQTVAESQEAVF-------ECEVAN-PDSKGEW-LRDGKHLPLTNN 2664
Query: 2288 FMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPAT 2347
D G +R ++ + + G+YT + K +++V+ V T
Sbjct: 2665 IRSESD--GHKRRLII--------AATKLDDIGEYT--YKVATSKTSAKLKVEAVKIKKT 2712
Query: 2348 IRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQK 2407
++N T Q V KG V W+ N V+ S+EKY I GT+
Sbjct: 2713 LKNLTVTETQDAVFTVELTHPNVKG-----VQWIK--NGVVLESNEKYAISVKGTI---- 2761
Query: 2408 AQRSDSGNYTCLVRNSAGED---------RKTVWIHVNVQPPKINGNPNPITTVREIAAG 2458
Y+ ++N A D R ++V+ KI P +T +
Sbjct: 2762 --------YSLRIKNCAIVDESVYGFRLGRLGASARLHVETVKIIKKPKDVTALENATV- 2812
Query: 2459 GSRKLIDCKAEGIPTPRVLWAFPEGV---VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQ 2515
AF V +P ++ + + + + S RK +
Sbjct: 2813 --------------------AFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLM 2852
Query: 2516 LVCMARNEGGEARLIL-QLTVLEPMEKPIFH-DPISEKITAMAGHTISLNCSAAGTPTPS 2573
L ++ ++ GE ++ QL + H + I T S C + PS
Sbjct: 2853 LQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPS 2912
Query: 2574 LVWVLPNGTDLQSGQQLQRFYHKADGMLH---ISGLSSVDAGAYRCVARN 2620
+ W L NG +++ ++F G LH I S+ D+ Y V N
Sbjct: 2913 M-W-LKNGVEIEMS---EKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGN 2957
Score = 51.6 bits (122), Expect = 1e-05
Identities = 128/595 (21%), Positives = 209/595 (35%), Gaps = 67/595 (11%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
E P+I + Q+ +V +D F GKP P W K G + + RI + N
Sbjct: 2076 EAPKIFERI-QSQTVGQGSDAHFRVRVVGKPDPECEWYK--NGVKIERSDRIYWYWPEDN 2132
Query: 1911 GT-LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIA 1969
LVIR V +D M A N+ G L V +Q QDV DT+A
Sbjct: 2133 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMA 2192
Query: 1970 MECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRT---LSIKEASFSDRGVYKCV 2026
P ++ W V + + +H +R LSI SD Y CV
Sbjct: 2193 TFECETSEPFVKVKWYKDGMEVHE-----GDKYRMHSDRKVHFLSILTIDTSDAEDYSCV 2247
Query: 2027 ASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDG 2086
+ A + A+ + ++L++I +P S + C + +W D
Sbjct: 2248 LVEDENVKTTAKLIVEGAVVEFV--KELQDIEVPESYSGELECIVSPENIEG-KWYHNDV 2304
Query: 2087 TQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANA 2146
++ + N L ++++ +D G Y V + + T +L + + A
Sbjct: 2305 ELKSNGKYTITSRRGRQN--LTVKDVTKEDQGEYSFV----IDGKKTTCKLKM-KPRPIA 2357
Query: 2147 RITGTSPRRTDVRYGGTLKLDCSASGDP----WPRILWRLPSKRMIDALFSFDSRIKVFA 2202
+ G S ++ V G ++L+ S + W + + + + S +
Sbjct: 2358 ILQGLSDQK--VCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHM---- 2411
Query: 2203 NGTLVVKSVTDKDAGDY---LCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGG 2259
L+++ +T +DAG+Y + V VDV+ P K D V G
Sbjct: 2412 ---LLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVI-TPLK-------DVNVIEGT 2460
Query: 2260 DLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREE 2319
++C + + W L D + + DD R + V L N +E
Sbjct: 2461 KAVLECKVSVPDVTSVKWYLNDEQI-----KPDD---RVQAIVKGTKQRLVINRTHASDE 2512
Query: 2320 GDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVT 2379
G Y VG+ E + V IR L V V G V
Sbjct: 2513 GPYKLI----VGRVETNCNLSVEKI-KIIRGLRDLTCTETQNVVFEVELSHSG---IDVL 2564
Query: 2380 WLSPTNKVIPTSSEKYQIYQDG---TLLIQKAQRSDSGNYTCLVRNSAGEDRKTV 2431
W ++ P+S KY+I G L + + D G YT + + TV
Sbjct: 2565 WNFKDKEIKPSS--KYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTV 2617
Score = 51.6 bits (122), Expect = 1e-05
Identities = 102/481 (21%), Positives = 172/481 (35%), Gaps = 66/481 (13%)
Query: 1988 DRRVWQTVSPVEG-RIT------LHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL 2040
D WQ V+P G R+T L E++ I+ + + G+ + A++ G +L
Sbjct: 23962 DEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGE--ATSVPGTVKPEDKL 24019
Query: 2041 HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF 2100
L + E + I + G S IH K P P + W +G Q G +
Sbjct: 24020 EAPELD--LDSELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNY 24077
Query: 2101 VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRY 2160
L I N D+G+Y N GS V + V + R D +
Sbjct: 24078 T----QLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAF 24133
Query: 2161 GGTLKLDCSASGDPWPRILWRLP-----SKRMIDALFSFDSRIKVFAN-------GTLVV 2208
++W P +K + +S K +AN + V
Sbjct: 24134 -----------------LVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKV 24176
Query: 2209 KSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVAT 2268
+++T+ + +A N+ G V VD V K A+ KV
Sbjct: 24177 ENLTEGAIYYFRVMAENEFGVGVPVETVDAV-KAAEPPSPPG-----------KVTLTDV 24224
Query: 2269 GLPNPEISWSLPD---GSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR--EEGDYT 2323
+ + W P+ GS V ++ G K +V + G+ +E +
Sbjct: 24225 SQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFR 24284
Query: 2324 CFAENQVGKDEMRVR-VKVVTAPATIRNKTYL---AVQVPYGDVVTVACEAKGEPMPKVT 2379
A N+ GK + RV V V+ TI+ L + G+ + + G P P ++
Sbjct: 24285 VKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNIS 24344
Query: 2380 WLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQ 2438
W+ + T+ + T+L I++ + D G YT NSAG + + + V +
Sbjct: 24345 WVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEK 24404
Query: 2439 P 2439
P
Sbjct: 24405 P 24405
Score = 50.8 bits (120), Expect = 2e-05
Identities = 104/458 (22%), Positives = 155/458 (33%), Gaps = 93/458 (20%)
Query: 2433 IHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYG 2492
+ + V PP + +T + G ++C G P+P V W + E + +
Sbjct: 936 VEIPVTPPTLVSGLKNVTVIE-----GESVTLECHISGYPSPTVTW-YREDYQIESSIDF 989
Query: 2493 NRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG--------------------------- 2525
G L IR DS + C A NE G
Sbjct: 990 QITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKF 1049
Query: 2526 ---EARLILQLTVL--------------EPMEKPIFHDPISEKITAMAGHTISLNCSAAG 2568
E R + V+ EP P+ +K+ + G ++ C G
Sbjct: 1050 TTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKL--VEGGSVVFGCQVGG 1107
Query: 2569 TPTPSLVWVLPNGTDLQSGQQLQRFYHKADG--MLHISGLSSVDAGAYRCVARNAAGHTE 2626
P P + W +G L +G + + Y+K G L IS + DAG Y V RN G T
Sbjct: 1108 NPKPHVYWK-KSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETS 1166
Query: 2627 RLVSL------KVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLE 2680
SL ++ +K + Y V+ E K+ T PG + E
Sbjct: 1167 ASASLLEEADYELLMKSQQEMLYQTQVTAFVQEP-KVGETAPGFVYSEYE------KEYE 1219
Query: 2681 GPQTLGRVSLLDNGTLTVR---EASVFDRGTYVCRM--ETEYGPSVTSIPVIV------- 2728
Q L R + + T+ VR E F ++ R+ E EY T++ ++
Sbjct: 1220 KEQALIRKKMAKD-TVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEK 1278
Query: 2729 ----IAYPPRITSEPTPVIYT---RPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQA 2781
I+ + S I G V +C G P I W D +K G +
Sbjct: 1279 MAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAW-YKDGKRIKHGER- 1336
Query: 2782 RLYGNRFLHP-QGSLTIQHATQRDAGFYKCMAKNILGS 2818
Y FL + SL I D G Y A NI G+
Sbjct: 1337 --YQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGN 1372
Score = 50.8 bits (120), Expect = 2e-05
Identities = 48/184 (26%), Positives = 67/184 (36%), Gaps = 15/184 (8%)
Query: 1873 FPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN-GTLVIRKVQVQDRGQYMCTAS 1931
F T P+P VTW K N + FE K L I V D +Y A
Sbjct: 31709 FGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVAR 31768
Query: 1932 NLHGLDRMVVLLSVTVQQPQ-------ILASHYQDVTVYLGDTIAMECLAKGTPAPQISW 1984
N +G D L+VT+ P + + G ++ E G P P + W
Sbjct: 31769 NKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKW 31828
Query: 1985 IFPDRRVWQTVSPVEGRITLHENR---TLSIKEASFSDRGVYKCVASNAAGADSLAIRLH 2041
+ Q +S +HE L I++ D G Y+ A+N AG+ S L
Sbjct: 31829 ----EKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQ 31884
Query: 2042 VAAL 2045
V L
Sbjct: 31885 VERL 31888
Score = 50.8 bits (120), Expect = 2e-05
Identities = 166/907 (18%), Positives = 303/907 (33%), Gaps = 194/907 (21%)
Query: 1958 QDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASF 2017
+ +TVY G++ C G P P ++W+ + V T + + T +++ T I
Sbjct: 32568 RSMTVYEGESARFSCDTDGEPVPTVTWLRKGQ-VLSTSARHQVTTTKYKS-TFEISSVQA 32625
Query: 2018 SDRGVYKCVASNAAGADSLAIRL------------------------------------- 2040
SD G Y V N+ G L
Sbjct: 32626 SDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRV 32685
Query: 2041 ------HVAALPPVIHQ----EKLEN--ISLPPGLS-----------IHIHCTAKAAPLP 2077
H A+ P + EK+++ +S PP ++ + C +++ L
Sbjct: 32686 KSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLR 32745
Query: 2078 S--VRWVLGDGTQIRPSQFLHGNLFVFPNGT--LYIRNLAPKDSGRYECVAANLVGSARR 2133
+ V W DG +++ + H +GT L I NL D G Y C + G+++
Sbjct: 32746 AKEVTWYK-DGKKLKENG--HFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKT 32802
Query: 2134 TVQL--------------------NVQRAAANARITGTSPRR----------------TD 2157
+Q + Q+ + T P+ T
Sbjct: 32803 NLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTT 32862
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAG 2217
V K A+G+P P +W K + S K L + D+G
Sbjct: 32863 VSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDK--GGFFLEIHKTDTSDSG 32920
Query: 2218 DYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISW 2277
Y C +N G V K+ K D + KV T P+
Sbjct: 32921 LYTCTVKNSAGS---------VSSSCKLTIKAIKDTEA-----QKVSTQKTSEITPQ--- 32963
Query: 2278 SLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRV 2337
+ +Q + S + + + ++ ++EE +E +
Sbjct: 32964 -------KKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSL 33016
Query: 2338 RVKVV------TAPATIRNKTYLAV-----QVPYGDVVTVACEAKGEPMPKVTWLSPTNK 2386
+V T+ A+ +T+ + Q+ + + +A V W+ N
Sbjct: 33017 EKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGATDVKWV--LNG 33074
Query: 2387 VIPTSSEKYQIYQDG---TLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKIN 2443
V T+SE+Y+ G TL I++A D G TC+ + G + + ++ + ++
Sbjct: 33075 VELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKE---LS 33131
Query: 2444 GNPNPITTVREIAAG-GSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGS 2502
P I+ R G L C+ G P+P + W F + + + S
Sbjct: 33132 DAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEW-FKNNLPISISSNVSISRSRNVYS 33190
Query: 2503 LDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTI-- 2560
L+IR+ SDS + A+N G+ L VL P+ +P E + +G T
Sbjct: 33191 LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL-----PLVEEPSREVVLRTSGDTSLQ 33245
Query: 2561 ------SLNCSA----------AGTPTPSLVWVLPNGTDLQSGQQLQRFY--HKADGMLH 2602
S+ SA + + S+ + QS +Q + + +
Sbjct: 33246 GSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMG 33305
Query: 2603 ISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPP 2662
IS ++ +++ + + G ++ +L + +SI G+ L + C
Sbjct: 33306 ISNMTQLESSTSKMLKAGIRGIPPKIEALP------------SDISIDEGKVLTVACAFT 33353
Query: 2663 GAGQGRFSWTLPNGMHLEGPQTLGRVSLL---DNGTLTVREASVFDRGTYVCRMETEYGP 2719
G +W+ G Q GR + D TL + + D G Y + E+G
Sbjct: 33354 GEPTPEVTWSC--GGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGS 33411
Query: 2720 SVTSIPV 2726
++ +
Sbjct: 33412 DSATVNI 33418
Score = 50.4 bits (119), Expect = 2e-05
Identities = 58/207 (28%), Positives = 85/207 (41%), Gaps = 23/207 (11%)
Query: 478 MIEPSGAVQRDQ--TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSIL 535
++EP+ +++ + TV G P L C V + S W DG L A DSK I
Sbjct: 6641 VLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKW-FKDGRELSA-----DSKHHIT 6694
Query: 536 ---SSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQ------SPSTQPAEKDTVT 586
L+I E SD GLY +V++ + + V V PS KD
Sbjct: 6695 FINKVASLKIPCAEMSDKGLYSF--EVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNA 6752
Query: 587 IGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDS 646
I G SV L C + W I++ S + TL++ ++ SD+
Sbjct: 6753 I---LGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSS-FSENVCTLNLSLLEPSDT 6808
Query: 647 GYYRCVAVNQQGADHFTVGITVTKKGS 673
G Y CVA N G+D + +TV + S
Sbjct: 6809 GIYTCVAANVAGSDECSAVLTVQEPPS 6835
Score = 50.4 bits (119), Expect = 2e-05
Identities = 118/592 (19%), Positives = 216/592 (36%), Gaps = 84/592 (14%)
Query: 1851 EKPQILTKSPQTVSVTAETDTV-FPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLK 1909
E+ + TK+ + V+ ETDT+ CE + KP V W K + T R+E+L
Sbjct: 12460 EEEAVFTKNLANIEVS-ETDTIKLVCEVS-KPGAEVIWYKGDEEIIETG-----RYEILT 12512
Query: 1910 NGT---LVIRKVQVQDRGQYMCT--ASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYL 1964
G LVI+ ++D G Y C +S G ++ L + + +PQ ++ +
Sbjct: 12513 EGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFISKPQ-------NLEILE 12565
Query: 1965 GDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYK 2024
G+ C P + W D+ + I + R L +K+A+ D G Y
Sbjct: 12566 GEKAEFVCSISKESFP-VQWKRDDKTLES--GDKYDVIADGKKRVLVVKDATLQDMGTYV 12622
Query: 2025 CVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLG 2084
+ A A L + + + P L++ + + +C +W
Sbjct: 12623 VMVGAARAAAHLTVIEKLRIVVP------LKDTRVKEQQEVVFNCEVNTEG-AKAKWFRN 12675
Query: 2085 DGTQIRPSQF--LHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVG-----SARRTVQL 2137
+ S++ L +L TL IR+ D Y N G +A V+
Sbjct: 12676 EEAIFDSSKYIILQKDLVY----TLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEE 12731
Query: 2138 NVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSR 2197
R + T +++ + +L+ + W + +P FD+R
Sbjct: 12732 EDLRIVEPLKDIETMEKKSVTFWCKVNRLNVTLK---WTKNGEEVP----------FDNR 12778
Query: 2198 IKVFAN---GTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAK-IEHKEENDH 2253
+ + L +K D G+Y+ A G D V ++ ++ P + +EH E+
Sbjct: 12779 VSYRVDKYKHMLTIKDCGFPDEGEYIVTA----GQDKSVAELLIIEAPTEFVEHLEDQTV 12834
Query: 2254 KVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNE 2313
F D V + W + + G R ++ +
Sbjct: 12835 TEF---DDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLII--------KD 12883
Query: 2314 VGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGE 2373
+ +E +Y C E++ + R R+ V P I ++ P DVV +A +
Sbjct: 12884 CRLDDECEYACGVEDR----KSRARLFVEEIPVEIIRPPQDILEAPGADVVFLA--ELNK 12937
Query: 2374 PMPKVTWLSPTNKVIPTSSEKYQIYQDG---TLLIQKAQRSDSGNYTCLVRN 2422
+V WL N ++ +K+Q+ +G L I + D G Y + ++
Sbjct: 12938 DKVEVQWL--RNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKD 12987
Score = 50.4 bits (119), Expect = 2e-05
Identities = 115/559 (20%), Positives = 202/559 (36%), Gaps = 93/559 (16%)
Query: 1940 VVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVE 1999
V+ +T+Q L + ++ G+ + +E G P P ISW+ + QT
Sbjct: 24303 VIAKDLTIQPS--LKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTT---- 24356
Query: 2000 GRITLHENRT---LSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP-PVIHQEKLE 2055
R+ + E T L IKE + D G Y A+N+AG + + + V P P + + +
Sbjct: 24357 -RVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFD 24415
Query: 2056 NISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPK 2115
+S A + W P + G + YI
Sbjct: 24416 EVS---------------ADFVVISW--------EPPAYTGGCQI-----SNYIVEKRDT 24447
Query: 2116 DSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPR---RTDVRYGGTLKLDCSASG 2172
+ + V+A + AR T+++ + TGT + + RYG + LD A
Sbjct: 24448 TTTTWHMVSATV---ARTTIKITKLK-------TGTEYQFRIFAENRYGKSAPLDSKAVI 24497
Query: 2173 DPWPRILWRLPSKRMIDALFSFDSRIK----VFANGTLVV-KSVTDKDAGDYLCVARNKV 2227
+P P + ++ ++ V GT ++ + K+ L V NK
Sbjct: 24498 VQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSILWVKLNKT 24557
Query: 2228 GDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVD--------CVATGLP-------- 2271
K + + + E K ++ V G KV C G P
Sbjct: 24558 PIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRN 24617
Query: 2272 NPEISWSLP---DGSLVNSFM--QSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTC-- 2324
N + W P GS + ++ + D GR + N F G+ E+ Y
Sbjct: 24618 NVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRV 24677
Query: 2325 --------FAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMP 2376
F+E + R ++ A++ K + V G+ + + +G+P+P
Sbjct: 24678 IARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIP 24737
Query: 2377 KVTWLSPTNKVIPTSSEKYQI---YQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWI 2433
V W S K + ++ + +I Q TL+++ R+D G Y + N G + +
Sbjct: 24738 DVVW-SKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITV 24796
Query: 2434 HVNVQPPKINGNPNPITTV 2452
V +P G P +T V
Sbjct: 24797 KVLDRPGPPEG-PLKVTGV 24814
Score = 50.1 bits (118), Expect = 3e-05
Identities = 42/183 (22%), Positives = 72/183 (39%), Gaps = 8/183 (4%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLY 553
G C L C V S S+ W I+ ++ + L++ S++ SD G Y
Sbjct: 5814 GASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCT---LQLNSLDSSDMGNY 5870
Query: 554 QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWIL 613
C+A D + VQ P + E + + + PG++VT P ++W
Sbjct: 5871 TCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEV--LPGKNVTFTSVIRGTPPFKVNWFR 5928
Query: 614 PNRRIINDLANTSHVYMLPN-GTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKG 672
R ++ + ++Y L + + +S SG Y CV N G T + V +
Sbjct: 5929 GARELVK--GDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPA 5986
Query: 673 SGL 675
+ L
Sbjct: 5987 AFL 5989
Score = 50.1 bits (118), Expect = 3e-05
Identities = 55/216 (25%), Positives = 87/216 (40%), Gaps = 16/216 (7%)
Query: 2460 SRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNG--SLDIRSLRKSDSVQLV 2517
S + CK G P P V W + +G + A RI G L I S+ D+
Sbjct: 30943 SNATLVCKVTGHPKPIVKW-YRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQ 31001
Query: 2518 CMARNEGGEARLILQLTVLEPMEKPIFHDPISEK----ITAMAGHTISLNCSAAGTPTPS 2573
A N+GG L V P + H P + + + A+ G +S+ +G P P
Sbjct: 31002 VRATNQGGSVSGTASLEVEVPAK---IHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPV 31058
Query: 2574 LVWVLPNGTDL--QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSL 2631
+ W G DL +G ++ +G+ DAG Y A+N G ++ V L
Sbjct: 31059 ITW--QKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVEL 31116
Query: 2632 KVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQG 2667
V P+ + VS ++ +++ L T P + G
Sbjct: 31117 DVADVPDPPRGVK--VSDVSRDSVNLTWTEPASDGG 31150
Score = 49.7 bits (117), Expect = 4e-05
Identities = 53/195 (27%), Positives = 79/195 (40%), Gaps = 16/195 (8%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
TV EG QLSC+V+ SE I W L G +K P D F+ + L ++ + +D
Sbjct: 8356 TVSEGEYVQLSCHVQGSEPIRIQW-LKAGREIK-PSDRCSFSFAS-GTAVLELRDVAKAD 8412
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQS-PSTQPAEKDTVTIGK----NPGESVTLPCNALAI 604
SG Y C A D +V ++ P+ PA K G+ + +S+ + A
Sbjct: 8413 SGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTAT 8472
Query: 605 --------PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
P ++ W R +N L I +DSG YRCVA N+
Sbjct: 8473 FIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNE 8532
Query: 657 QGADHFTVGITVTKK 671
G V + V ++
Sbjct: 8533 HGEIESNVNLQVDER 8547
Score = 49.7 bits (117), Expect = 4e-05
Identities = 68/295 (23%), Positives = 116/295 (39%), Gaps = 36/295 (12%)
Query: 1852 KPQILTKSPQTVSVTAETDTVFPCEAT-GKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
+P L K + +V + D VF + P+ ++W K + + P+ +FE+ +
Sbjct: 8654 EPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEK--LEPS---DKFEISID 8708
Query: 1911 G---TLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDT 1967
G TL ++ Q++D+G Y + +TV +P H QDVT+ G T
Sbjct: 8709 GDRHTLRVKNCQLKDQGNYRLVCGP------HIASAKLTVIEPA-WERHLQDVTLKEGQT 8761
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVA 2027
M C P + W F + R+ + + + H+ L+I + D+G Y C
Sbjct: 8762 CTMTC-QFSVPNVKSEW-FRNGRILKPQGRHKTEVE-HKVHKLTIADVRAEDQGQYTCKY 8818
Query: 2028 SNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGT 2087
+ + L I P+ ++++NI + S C V W G
Sbjct: 8819 EDLETSAELRIEAE-----PIQFTKRIQNIVVSEHQSATFECEVSFDD-AIVTWYKG--- 8869
Query: 2088 QIRPSQFLHGNLFVFPNG----TLYIRNLAPKDSGRYECVA-ANLVGSARRTVQL 2137
P++ + F N + I N+ P D G Y +A G AR T +L
Sbjct: 8870 ---PTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAEL 8921
Score = 49.7 bits (117), Expect = 4e-05
Identities = 40/180 (22%), Positives = 80/180 (44%), Gaps = 23/180 (12%)
Query: 1941 VLLSVTVQQPQIL--ASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPV 1998
VL+ ++ P+++ A+ ++ + +GDT+ + + KG P P+++W DR +P
Sbjct: 17207 VLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRD-----APT 17261
Query: 1999 EGRITLHE-NRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENI 2057
+ RI + L I+ A+ D G+Y N AG+ ++++++ V P ++ I
Sbjct: 17262 KARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEI 17321
Query: 2058 -----------SLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFL----HGNLFVF 2102
L G S+ + + + S +W T + S F GN ++F
Sbjct: 17322 RKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLF 17381
Score = 49.7 bits (117), Expect = 4e-05
Identities = 70/299 (23%), Positives = 112/299 (37%), Gaps = 45/299 (15%)
Query: 2051 QEKLENISLPPGLSIHIHCTAKAAPLPSVRW------VLGDGTQIRPSQFLHGNLFVFPN 2104
+E+L N+++ + + C P P V+W ++ DG + R +F G
Sbjct: 30931 KEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGY------ 30984
Query: 2105 GTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRY--GG 2162
L I ++ D+ Y+ A N GS T L V+ A + T V G
Sbjct: 30985 HQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVE-VPAKIHLPKTLEGMGAVHALRGE 31043
Query: 2163 TLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCV 2222
+ + SG P P I W+ + +ID + + + V KDAG Y+
Sbjct: 31044 VVSIKIPFSGKPDPVITWQ-KGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVC 31102
Query: 2223 ARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDG 2282
A+N+ G D +++DV P +KV V+ N ++W+ P
Sbjct: 31103 AKNRFGIDQKTVELDVADVPDPPR-------------GVKVSDVSRDSVN--LTWTEP-- 31145
Query: 2283 SLVNSFMQSDDSGGRTKRYVVFNNGTL--YFNEVGMREEGDYTCFAENQVGKDEMRVRV 2339
+ D G + Y+V T + VG E YT N GK + RV
Sbjct: 31146 --------ASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVI--NLFGKTSYQFRV 31194
Score = 48.9 bits (115), Expect = 7e-05
Identities = 44/169 (26%), Positives = 67/169 (39%), Gaps = 7/169 (4%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSS-GWLRIKSMEPSDSGL 552
G P C + SE + W DG +LK DD + + S + + L+I + S G
Sbjct: 7130 GFPVAFECRINGSEPLQVSWY-KDGVLLK---DDANLQTSFVHNVATLQILQTDQSHIGQ 7185
Query: 553 YQCIAQVRDEMDRMVYRVLVQSPSTQPA-EKDTVTIGKNPGESVTLPCNALAIPEAHLSW 611
Y C A ++++ P + V++ GES T C+ ++W
Sbjct: 7186 YNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITW 7245
Query: 612 ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD 660
NR I N + TL++ KV D+G Y C A N G D
Sbjct: 7246 AKDNREI-RPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKD 7293
Score = 48.9 bits (115), Expect = 7e-05
Identities = 33/120 (27%), Positives = 52/120 (43%), Gaps = 3/120 (2%)
Query: 2521 RNEGGEARLIL--QLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVL 2578
+NEGGE+ + ++ V E ++KP+ +S +T AG TI L G P P + W
Sbjct: 18178 KNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTK 18237
Query: 2579 -PNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP 2637
+ TDL +++ ++ D G Y A N AG ++ V KP
Sbjct: 18238 DKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKP 18297
Score = 48.5 bits (114), Expect = 9e-05
Identities = 31/124 (25%), Positives = 57/124 (45%), Gaps = 10/124 (8%)
Query: 2312 NEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAK 2371
N G+ E G+ T D + ++ ++V+ + + V G V+ +
Sbjct: 16499 NIAGIGEPGEVT---------DVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVS 16549
Query: 2372 GEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTV 2431
G+P P VTW + + +P + +++I+ QRS G Y+ L +N AGE +KT+
Sbjct: 16550 GKPPPTVTW-NMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTI 16608
Query: 2432 WIHV 2435
+ V
Sbjct: 16609 IVDV 16612
Score = 48.1 bits (113), Expect = 1e-04
Identities = 43/171 (25%), Positives = 72/171 (42%), Gaps = 8/171 (4%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
V++ +L C V + + W+ + I + + S+ + L I +PSD+
Sbjct: 4966 VVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFN---LHITKCDPSDT 5022
Query: 551 GLYQCIAQVRDEMDRMVYRV-LVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHL 609
G YQCI RV L + PS ++T T+ K+ S T P +
Sbjct: 5023 GEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKS---SATFQSTVAGSPPISI 5079
Query: 610 SWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD 660
+W L + +I+++ N ++ TL I V SG Y C A N+ G +
Sbjct: 5080 TW-LKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVE 5129
Score = 48.1 bits (113), Expect = 1e-04
Identities = 88/419 (21%), Positives = 152/419 (36%), Gaps = 63/419 (15%)
Query: 1954 ASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRT-LSI 2012
AS + V V G I + + +G PAP+++W R+V +G++ L + L I
Sbjct: 18610 ASMRKLVIVRAGCPIRLFAIVRGRPAPKVTW----RKVGIDNVVRKGQVDLVDTMAFLVI 18665
Query: 2013 KEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENIS--------LPP--- 2061
++ D G Y N AG ++ + + V P + K+ +++ PP
Sbjct: 18666 PNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPEND 18725
Query: 2062 GLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSG--- 2118
G S H + W +++ + F NL P Y R A + G
Sbjct: 18726 GGSQVTHYIVEKREADRKTWSTVT-PEVKKTSFHVTNL--VPGNEYYFRVTAVNEYGPGV 18782
Query: 2119 ----RYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLD---CSAS 2171
+A++ + +L V N+ P D G K+D S
Sbjct: 18783 PTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRD----GGAKIDGYITSYR 18838
Query: 2172 GDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG--- 2228
+ P W + V + +LVV + + + ARN VG
Sbjct: 18839 EEEQPADRW---------------TEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSL 18883
Query: 2229 --DDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVN 2286
+ V + + P KI E+ K G L+++ G P+P W + +V
Sbjct: 18884 PREAEGVYEAKEQLLPPKILMPEQITIKA--GKKLRIEAHVYGKPHPTCKWKKGEDEVVT 18941
Query: 2287 SFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAP 2345
S + ++ L +V ++ G Y+ AEN G D +++V V+ AP
Sbjct: 18942 S--------SHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAP 18992
Score = 48.1 bits (113), Expect = 1e-04
Identities = 112/511 (21%), Positives = 185/511 (36%), Gaps = 92/511 (18%)
Query: 1987 PDRRVWQTVSPVEG------RIT-LHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIR 2039
P+ WQ V+P G IT L EN+ I+ + + G+ + + G R
Sbjct: 21797 PEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGE--PALVPGTPKAEDR 21854
Query: 2040 LHVAALPPVIHQEK--LENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHG 2097
+ LPP I + + +++ ++ + K P P V+W G + +
Sbjct: 21855 M----LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIEST 21910
Query: 2098 NLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTD 2157
+ + L + N+ DSG+Y N GS + A N R+ T D
Sbjct: 21911 SSYTL----LIVGNVNRFDSGKYILTVENSSGS---------KSAFVNVRVLDTPGPPQD 21957
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAG 2217
++ K + + DP L S+IK + +V K + + A
Sbjct: 21958 LKVKEVTKTSVTLTWDP---------------PLLDGGSKIKNY----IVEKRESTRKA- 21997
Query: 2218 DYLCVARNKVGDDYVVLKVDVVMKPAKIEHK--EENDHKVFYGGDLKVDCVATGLPNP-- 2273
Y VA N + KVD + + + EN++ + + A+ P P
Sbjct: 21998 -YSTVATNCHKTSW---KVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPG 22053
Query: 2274 ------------EISWSLPD---GSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGM-- 2316
+SW P+ GS + ++ + G K G+
Sbjct: 22054 KITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQ 22113
Query: 2317 REEGDYTCFAENQVG-KDEMRVRVKVVTAPATIRNKTYLAVQ---VPYGDVVTVACEAKG 2372
EE + A+N+ G D ++ V V+ I L V G+ + V G
Sbjct: 22114 GEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIG 22173
Query: 2373 EPMPKVTW------LSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGE 2426
P P VTW L T +V S+E + L I+ A R D G+Y + NSAGE
Sbjct: 22174 RPTPAVTWHKDNVPLKQTTRVNAESTENNSL-----LTIKDACREDVGHYVVKLTNSAGE 22228
Query: 2427 DRKTVWIHVNVQPPKINGNPNPITTVREIAA 2457
+T+ + V +P G P + E+ A
Sbjct: 22229 AIETLNVIVLDKP----GPPTGPVKMDEVTA 22255
Score = 47.8 bits (112), Expect = 2e-04
Identities = 52/185 (28%), Positives = 75/185 (40%), Gaps = 22/185 (11%)
Query: 2255 VFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSF----MQSDDSGGRTKRYVVFNNGTLY 2310
V G + +G P PE+SW DG ++++ +Q S GR K L
Sbjct: 17 VLEGSTATFEAHISGFPVPEVSW-FRDGQVISTSTLPGVQISFSDGRAK---------LT 66
Query: 2311 FNEVGMREEGDYTCFAENQVGK--DEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVAC 2368
V G Y+ A N G+ + VK TAP + ++ V G V +
Sbjct: 67 IPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQ-SMTVRQGSQVRLQV 125
Query: 2369 EAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDG---TLLIQKAQRSDSGNYTCLVRNSAG 2425
G P P V + ++ SS +QI Q+G +LLI +A DSG Y+ NS G
Sbjct: 126 RVTGIPTPVVKFYRDGAEI--QSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Query: 2426 EDRKT 2430
T
Sbjct: 184 RATST 188
Score = 47.8 bits (112), Expect = 2e-04
Identities = 61/264 (23%), Positives = 96/264 (36%), Gaps = 58/264 (21%)
Query: 2206 LVVKSVTDKDAGDYLCVARNKVGDD--YVVLKVDVVMKP---------AKIEHKEEN--- 2251
L VK +T D G Y C N G+D Y L V V + KI+ + +
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRL 31685
Query: 2252 ------------DHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTK 2299
+ + G +++ T P P ++W Q G K
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSG--------QKIKPGDNDK 31737
Query: 2300 RYVVFNNGTLY---FNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAP----ATIRN-- 2350
+Y ++ LY N V ++ +YT A N+ G+D + ++ V P +T+R
Sbjct: 31738 KYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMF 31797
Query: 2351 KTYLA-VQVPYGDVVTVACEAKGEPMPKVTW--------LSPTNKVIPTSSEKYQIYQDG 2401
K LA + G V G P P + W L P ++I + Y ++
Sbjct: 31798 KRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRD 31857
Query: 2402 TLLIQKAQRSDSGNYTCLVRNSAG 2425
TL D+G Y N+AG
Sbjct: 31858 TL------PEDTGYYRVTATNTAG 31875
Score = 47.4 bits (111), Expect = 2e-04
Identities = 65/259 (25%), Positives = 103/259 (39%), Gaps = 35/259 (13%)
Query: 2205 TLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVD 2264
TL VK+ KD G+Y V G K+ V+ +PA H ++ K G +
Sbjct: 8713 TLRVKNCQLKDQGNYRLVC----GPHIASAKLTVI-EPAWERHLQDVTLKE--GQTCTMT 8765
Query: 2265 CVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTC 2324
C + +PN + W +G ++ GR K V L +V ++G YTC
Sbjct: 8766 CQFS-VPNVKSEW-FRNGRILKP-------QGRHKTEVEHKVHKLTIADVRAEDQGQYTC 8816
Query: 2325 FAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPT 2384
E+ E+R+ + + I+N + V T CE + VTW
Sbjct: 8817 KYEDLETSAELRIEAEPIQFTKRIQN-----IVVSEHQSATFECEVSFDD-AIVTWYKGP 8870
Query: 2385 NKVIPTSSEKYQIYQDGT---LLIQKAQRSDSGNYTCLVR-NSAGEDRKTVWIH------ 2434
++ T S+KY DG + I D G Y+ + R GE R T ++
Sbjct: 8871 TEL--TESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTKEI 8928
Query: 2435 -VNVQPPKINGNPNPITTV 2452
+ ++PP I + PI T+
Sbjct: 8929 KLELKPPDIPDSRVPIPTM 8947
Score = 47.4 bits (111), Expect = 2e-04
Identities = 36/128 (28%), Positives = 56/128 (43%), Gaps = 14/128 (10%)
Query: 2326 AENQVGKDEMRVRVKVVT----APATIRNKTYL---AVQVPYGDVVTVACEAKGEPMPKV 2378
A N++G+ E + + VV P TI+ + + ++V G+ V + + G PMPK+
Sbjct: 15371 AVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKI 15430
Query: 2379 TWLS-------PTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTV 2431
W PT+ + T E + L I KA R D G YT N G + V
Sbjct: 15431 EWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNV 15490
Query: 2432 WIHVNVQP 2439
+ V +P
Sbjct: 15491 HVEVYDRP 15498
Score = 47.4 bits (111), Expect = 2e-04
Identities = 48/215 (22%), Positives = 82/215 (38%), Gaps = 32/215 (14%)
Query: 2262 KVDCVATGLPNPEISWSLPD--------GSLVNSFMQSDD---SGGRTKRYVVFNNGTLY 2310
++D V T + ++W PD G L+ + D G TK+ T
Sbjct: 28551 RLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQL------TFT 28604
Query: 2311 FNEVGMREEGDYTCFAENQVGKDEMR-------VRVKVVTAPATIRNKTYLAVQVPYGDV 2363
+ + E ++ A+N G E R ++ + A + T + G
Sbjct: 28605 VERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSP 28664
Query: 2364 VTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRN 2422
T+ G P PKVTW ++ T +D T L ++ + R DSG Y + N
Sbjct: 28665 FTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLEN 28724
Query: 2423 SAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAA 2457
+AG +V + + G P P+T E+++
Sbjct: 28725 TAGVKTFSVTV-------VVIGRPGPVTGPIEVSS 28752
Score = 47.0 bits (110), Expect = 3e-04
Identities = 45/181 (24%), Positives = 71/181 (39%), Gaps = 11/181 (6%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG---WLRIKSMEP 547
V+ G C+V ++ I W + I P ++I G LRI +
Sbjct: 6282 VIAGESADFECHVTGAQPMRITWSKDNKEIR------PGGNYTITCVGNTPHLRILKVGK 6335
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
DSG Y C A D ++ V+ P + + + K GES+ L C PE
Sbjct: 6336 GDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQ-GESIQLECKISGSPEI 6394
Query: 608 HLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGIT 667
+SW N +++ + ++ L+I + DSG Y C A N G + +T
Sbjct: 6395 KVSW-FRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALT 6453
Query: 668 V 668
V
Sbjct: 6454 V 6454
Score = 47.0 bits (110), Expect = 3e-04
Identities = 136/653 (20%), Positives = 227/653 (34%), Gaps = 116/653 (17%)
Query: 2161 GGTLKLDCSASGDPWPRILWR---LPSKRMIDALFSFDSRIKVFA---NGTLVVKSVTDK 2214
G LK+D G P P + W +P K+ +R+ + N L +K +
Sbjct: 22162 GEDLKVDVPFIGRPTPAVTWHKDNVPLKQT--------TRVNAESTENNSLLTIKDACRE 22213
Query: 2215 DAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPE 2274
D G Y+ N G+ L V V+ KP G +K+D V +
Sbjct: 22214 DVGHYVVKLTNSAGEAIETLNVIVLDKPGPPT------------GPVKMDEVTAD--SIT 22259
Query: 2275 ISWSLPD---GSLVNSFM-QSDDSGGRTKRYVVFNNGTLYFNEVGMRE--EGDYTCFAEN 2328
+SW P GS +N+++ + D+ T + V ++ E + AEN
Sbjct: 22260 LSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAEN 22319
Query: 2329 QVGKDE------------MRVRVKVVTAPATIRNKTYLAVQ----VPYGDVVTVACEAKG 2372
+ GK +V T T+ ++ + VQ + G + +
Sbjct: 22320 RYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLER 22379
Query: 2373 EPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVW 2432
+ + W+ IP + K ++G ++ R + N + G+ K
Sbjct: 22380 KERNSILWVKLNKTPIPQTKFKTTGLEEG---VEYEFRVSAENIVGI-----GKPSKVSE 22431
Query: 2433 IHVNVQPPKINGNPNPITTVREIAA---------GGSRKLIDCKAEGIPTPRVLWAFPEG 2483
+V P G P I R GGS K G + PEG
Sbjct: 22432 CYVARDPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGS------KITGYIVEKK--ELPEG 22483
Query: 2484 VVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG----EARLILQLTVLEPM 2539
+ A + N I H ++ L + + +ARN G + +T + +
Sbjct: 22484 RWMKASFT-NIIDTH----FEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEV 22538
Query: 2540 EKP-IFHDP-ISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKA 2597
+ P I DP + I AG + ++ G P P++ W+ +L + +L+
Sbjct: 22539 DPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWI-KGDQELSNTARLEIKSTDF 22597
Query: 2598 DGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKL 2657
L + VD+G Y A+N AG V++KV +P + ++S + E L
Sbjct: 22598 ATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP-GPPEGPVVISGVTAEKCTL 22656
Query: 2658 PCTPPGAGQG--------------RFSWTLPNGMHLEGPQTLG--RVSLLDNGTLTVREA 2701
PP G R WT+ + QTL LL+ T R
Sbjct: 22657 AWKPPLQDGGSDIINYIVERRETSRLVWTVVDA----NVQTLSCKVTKLLEGNEYTFRIM 22712
Query: 2702 SVFDRGTYVCRMETEYGPSVTSIPVIVIAYP-----PRITSEPTPVIYTRPGN 2749
+V Y E P V P +V P +T + V++ RP +
Sbjct: 22713 AV---NKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPAS 22762
Score = 47.0 bits (110), Expect = 3e-04
Identities = 45/177 (25%), Positives = 71/177 (40%), Gaps = 18/177 (10%)
Query: 1787 PPLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKF 1846
P L T S + SS + S +T + +S S+ S+S K
Sbjct: 32486 PELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEK- 32544
Query: 1847 WSLGEKP-----------QILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGAL 1895
SL EK +ILTK P++++V F C+ G+P P VTW + G +
Sbjct: 32545 -SLEEKSTTRKIKTTLAARILTK-PRSMTVYEGESARFSCDTDGEPVPTVTWLR--KGQV 32600
Query: 1896 MTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQI 1952
++ + R Q T I VQ D G Y N G + ++T+Q+ ++
Sbjct: 32601 LSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEG--KQEAEFTLTIQKARV 32655
Score = 46.6 bits (109), Expect = 3e-04
Identities = 32/123 (26%), Positives = 57/123 (46%), Gaps = 4/123 (3%)
Query: 540 LRIKSMEPSDSGLYQC-IAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLP 598
L + ++ SDSG Y C ++ V ++ + V+ P+T + + + K G++ L
Sbjct: 4263 LELYLVKTSDSGTYTCKVSNVAGGVECSA-NLFVKEPATFVEKLEPSQLLKK-GDATQLA 4320
Query: 599 CNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
C P ++W N R I + + ++ L + V + DSG Y C A N+ G
Sbjct: 4321 CKVTGTPPIKITWFA-NDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAG 4379
Query: 659 ADH 661
+DH
Sbjct: 4380 SDH 4382
Score = 46.6 bits (109), Expect = 3e-04
Identities = 44/193 (22%), Positives = 84/193 (43%), Gaps = 28/193 (14%)
Query: 2459 GSRKLIDCKAEGIPTPRVLW-AFPEGVVLPAPYYGNRITVHGNG-SLDIRSLRKSDSVQL 2516
G + C+ G P P + W F + ++ Y +++ G +L + + + D
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKY---KMSSDGRTHTLTVMTEEQEDEGVY 30603
Query: 2517 VCMARNEGGE----ARLILQLTVLEPMEKPIFHD--PISEKITAMAGHTISLNCSAAGTP 2570
C+A NE GE ++L+LQ T P FH P+ EK G T+ L+ G P
Sbjct: 30604 TCIATNEVGEVETSSKLLLQAT-------PQFHPGYPLKEKYYGAVGSTLRLHVMYIGRP 30656
Query: 2571 TPSLVW-----VLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHT 2625
P++ W +L N ++ + + + + H ++ + AG Y+ N G
Sbjct: 30657 VPAMTWFHGQKLLQNSENI-TIENTEHYTH----LVMKNVQRKTHAGKYKVQLSNVFGTV 30711
Query: 2626 ERLVSLKVGLKPE 2638
+ ++ +++ KP+
Sbjct: 30712 DAILDVEIQDKPD 30724
Score = 46.6 bits (109), Expect = 3e-04
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 40/207 (19%)
Query: 2107 LYIRNLAPKDSGRYECVAANLVGS-------------------ARRTVQLNVQRAAANAR 2147
LY++++ D G Y C N G RRT++ ++R R
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMK-KIKRRTDTMR 31684
Query: 2148 ITGTSPRRTDVRY------GGTLKLDCSASGDPWPRILWRLPSKRMI----DALFSFDSR 2197
+ P T Y G ++ + + P P + W +++ D ++F+S
Sbjct: 31685 LLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESD 31744
Query: 2198 IKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFY 2257
++ L + SVT D +Y VARNK G+D K+ V + P + K
Sbjct: 31745 KGLYQ---LTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLL 31801
Query: 2258 -------GGDLKVDCVATGLPNPEISW 2277
G + + +G+P P + W
Sbjct: 31802 ANAECQEGQSVCFEIRVSGIPPPTLKW 31828
Score = 46.2 bits (108), Expect = 5e-04
Identities = 46/205 (22%), Positives = 80/205 (39%), Gaps = 7/205 (3%)
Query: 478 MIEPSGAVQRDQTV--LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSIL 535
+I PS + +TV EG +L V S+ ++ W + I + K + L
Sbjct: 8246 LIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTL 8305
Query: 536 SSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVT-IGKNPGES 594
L+++ +D+GLY C ++++ P P +T + + GE
Sbjct: 8306 V---LQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEY 8362
Query: 595 VTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAV 654
V L C+ + W+ R I S + L + V +DSG Y C A
Sbjct: 8363 VQLSCHVQGSEPIRIQWLKAGREI-KPSDRCSFSFASGTAVLELRDVAKADSGDYVCKAS 8421
Query: 655 NQQGADHFTVGITVTKKGSGLPSKR 679
N G+D +T+ K + P+ +
Sbjct: 8422 NVAGSDTTKSKVTIKDKPAVAPATK 8446
Score = 46.2 bits (108), Expect = 5e-04
Identities = 45/179 (25%), Positives = 78/179 (43%), Gaps = 15/179 (8%)
Query: 2275 ISWSLPD---GSLVNSFMQSDDSGGRTKRYVVFNNGTLY--FNEVGMREEG--DYTCFAE 2327
++W+ P GS + +++ G K + V N+ L + G++E +Y A
Sbjct: 16735 LTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAV 16794
Query: 2328 NQVGKDEMRVRVKVVT-----APATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLS 2382
N VG+ + K +T AP T+ + + G+ + G+P PKV+W
Sbjct: 16795 NIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFK 16854
Query: 2383 PTNKVIPTSSEKYQIYQDGTLLIQK--AQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP 2439
V+ + TL ++K A+RSDSG Y +V NS G + ++V +P
Sbjct: 16855 DEADVLEDDRTHIKT-TPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDRP 16912
Score = 46.2 bits (108), Expect = 5e-04
Identities = 77/396 (19%), Positives = 149/396 (37%), Gaps = 54/396 (13%)
Query: 1879 GKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDR 1938
G+P+P +TWTK G ++ R+ + L L I++ D G+Y+ +A N G +
Sbjct: 17934 GRPEPDITWTK--EGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQ 17991
Query: 1939 MVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIF----PDRRVWQT 1994
+++V + +VT TI+ E + ++I P+++ W
Sbjct: 17992 GSAIVNVLDRPGPCQNLKVTNVTKE-NCTISWENPLDNGGSEITNFIVEYRKPNQKGWSI 18050
Query: 1995 VSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKL 2054
V+ + + N L+ E F C + ++ + + A+ P+ +
Sbjct: 18051 VASDVTKRLIKAN-LLANNEYYFR-----VCAENKVGVGPTIETKTPILAINPIDRPGEP 18104
Query: 2055 ENISLP--------------------PGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQF 2094
EN+ + P LS H+ K S W I+ + +
Sbjct: 18105 ENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKG----SDDWERVHKGSIKETHY 18160
Query: 2095 LHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPR 2154
+ +Y + K+ G ++ V + V+ ++Q+ + +++G
Sbjct: 18161 MVDRCV---ENQIYEFRVQTKNEGG----ESDWVKTEEVVVKEDLQKPVLDLKLSGV--- 18210
Query: 2155 RTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTD- 2213
V+ G T++L+ G P+P + W K D S R+K+ S+T
Sbjct: 18211 -LTVKAGDTIRLEAGVRGKPFPEVAW-TKDKDATDLTRS--PRVKIDTRADSSKFSLTKA 18266
Query: 2214 --KDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEH 2247
D G Y+ A N G V+V+ KP + +
Sbjct: 18267 KRSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRN 18302
Score = 45.8 bits (107), Expect = 6e-04
Identities = 34/135 (25%), Positives = 57/135 (42%), Gaps = 3/135 (2%)
Query: 537 SGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVT 596
S L I S D+G Y C + D ++L+ P + + V + + G+S +
Sbjct: 7922 SAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKV--SVGDSAS 7979
Query: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
L C PE +SW + ++ H + TL +V ++DSG Y C A N
Sbjct: 7980 LQCQLAGTPEIGVSWYKGDTKLRPTTTYKMH-FRNNVATLVFNQVDINDSGEYICKAENS 8038
Query: 657 QGADHFTVGITVTKK 671
G + +TV ++
Sbjct: 8039 VGEVSASTFLTVQEQ 8053
Score = 45.8 bits (107), Expect = 6e-04
Identities = 32/118 (27%), Positives = 55/118 (46%)
Query: 1941 VLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEG 2000
V++ +Q+P + +TV GDTI +E +G P P+++W T SP
Sbjct: 18192 VVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVK 18251
Query: 2001 RITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENIS 2058
T ++ S+ +A SD G Y A+N AG+ ++V P + K+ ++S
Sbjct: 18252 IDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVS 18309
Score = 45.8 bits (107), Expect = 6e-04
Identities = 113/519 (21%), Positives = 185/519 (35%), Gaps = 79/519 (15%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWR---LPSKR--MIDALFSFDSRIKVFANGTLVVKSVT 2212
V+ G LK++ SG P P I W LP K+ I+ S D TL +K
Sbjct: 23241 VQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLT-------TLSIKETH 23293
Query: 2213 DKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPN 2272
D G Y N VG +++ + KP + G +K D V+ +
Sbjct: 23294 KDDGGQYGITVANVVGQKTASIEIVTLDKPDPPK------------GPVKFDDVSA--ES 23339
Query: 2273 PEISWSLP----DGSLVNSFMQSDDSGGRTKRYV--VFNNGTLYFNEVGMREEGDYTCFA 2326
+SW+ P + N +Q D+ V TL ++ E + FA
Sbjct: 23340 ITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFA 23399
Query: 2327 ENQVGKDEMRVRVKVV------------TAPATIRNKTYLAVQ----VPYGDVVTVACEA 2370
EN+ G+ +V T AT +K + +Q V G +
Sbjct: 23400 ENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHL 23459
Query: 2371 KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKT 2430
+ + + W +I + K Q ++G I+ R + N G+ K
Sbjct: 23460 ERKERNSILWTKVNKTIIHDTQFKAQNLEEG---IEYEFRVYAENIV-----GVGKASKN 23511
Query: 2431 VWIHVNVQPPKINGNPNPITTVR-EIAAGGSRKLIDCKAEGIPTPRVLWA--FPEGVVLP 2487
+V P G P PI R EI ++ + D + T ++ P+G +
Sbjct: 23512 SECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYD--GGSMITGYIVEKRDLPDGRWMK 23569
Query: 2488 APYYG---NRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG----EARLILQLTVLEPME 2540
A + + TV G L + + +A+N G + +T + +E
Sbjct: 23570 ASFTNVIETQFTVSG--------LTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVE 23621
Query: 2541 KP-IFHDP-ISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKAD 2598
P I DP + I AG T L G P P++ W L +++ + +
Sbjct: 23622 LPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEW-LRGDKEIEESARCEIKNTDFK 23680
Query: 2599 GMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP 2637
+L + +D G Y A N AG V++KV +P
Sbjct: 23681 ALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRP 23719
Score = 45.8 bits (107), Expect = 6e-04
Identities = 94/404 (23%), Positives = 143/404 (35%), Gaps = 56/404 (13%)
Query: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
G L++ +G P P I+WS Q D R + L ++V
Sbjct: 29461 GASLRLMVSVSGRPPPVITWS----------KQGIDLASRAIIDTTESYSLLIVDKVNRY 29510
Query: 2318 EEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPK 2377
+ G YT AENQ GK V VKV P + + V+ D VT+ E +P
Sbjct: 29511 DAGKYTIEAENQSGKKSATVLVKVYDTPGPCPS---VKVKEVSRDSVTITWE-----IPT 29562
Query: 2378 VTWLSPTNKVIPTSSE-KYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVN 2436
+ +P N I E + ++ T K SG LV + +
Sbjct: 29563 IDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISG----LVEGT--------MYYFR 29610
Query: 2437 VQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGI----PTPRVLWAFP--------EGV 2484
V P I G P T + L+ K E + T + W P G
Sbjct: 29611 VLPENIYGIGEPCETSDAVLV-SEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGY 29669
Query: 2485 VLPAPYYGN----RITVHGNGSLD--IRSLRKSDSVQLVCMARNEGGEA---RLILQLTV 2535
VL A G ++ L+ + SL + + A+NE G + + +TV
Sbjct: 29670 VLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTV 29729
Query: 2536 LEPMEKP-IFHDPISEK-ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRF 2593
+ P I + +K I AG + L AG P P+ W G+ L+ +++
Sbjct: 29730 QDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFA-GSKLRESERVTVE 29788
Query: 2594 YHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP 2637
H L I + D G Y +N G T + + + KP
Sbjct: 29789 THTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKP 29832
Score = 45.8 bits (107), Expect = 6e-04
Identities = 51/216 (23%), Positives = 85/216 (39%), Gaps = 29/216 (13%)
Query: 2081 WVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSAR-RTVQLNV 2139
W + +I+ QF G L T Y + A N G +R R +++
Sbjct: 30477 WKKSNKERIKDKQFTIGGLL---EATEY----------EFRVFAENETGLSRPRRTAMSI 30523
Query: 2140 QRAAANARITGTSPRRTDV--RYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSR 2197
+ + G DV + G +L C G P P I W K +I + +
Sbjct: 30524 KTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQS-----RK 30578
Query: 2198 IKVFANG---TLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHK 2254
K+ ++G TL V + +D G Y C+A N+VG+ V ++++ H +
Sbjct: 30579 YKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGE--VETSSKLLLQATPQFHPGYPLKE 30636
Query: 2255 VFY---GGDLKVDCVATGLPNPEISWSLPDGSLVNS 2287
+Y G L++ + G P P ++W L NS
Sbjct: 30637 KYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNS 30672
Score = 45.4 bits (106), Expect = 8e-04
Identities = 53/216 (24%), Positives = 82/216 (37%), Gaps = 28/216 (12%)
Query: 456 YTQYSQTISTKDTRQAR------GRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESP 509
YT Y+ I+ KD+ A+ R +EPS V++D+ + C + S
Sbjct: 7282 YTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFT------RYECKIGGSPEI 7335
Query: 510 SIFWVLPDGSILKAPMDDPDSKFSIL---SSGWLRIKSMEPSDSGLYQCIAQVRDEMDRM 566
+ W + I ++ SKF + S L + ++ DSG Y C A
Sbjct: 7336 KVLWYKDETEIQES------SKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASS 7389
Query: 567 VYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTS 626
+ V+ P + + K G V L C P H+SW R + +
Sbjct: 7390 STSLKVKEPPIFRKKPHPIETLK--GADVHLECELQGTPPFHVSWYKDKREL---RSGKK 7444
Query: 627 HVYMLPNGTLSIP--KVQVSDSGYYRCVAVNQQGAD 660
+ M N SI V +D G Y+C A N G+D
Sbjct: 7445 YKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSD 7480
Score = 45.4 bits (106), Expect = 8e-04
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 4/113 (3%)
Query: 1851 EKPQIL--TKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVL 1908
E P+I K ++V A T P TGKP+P +TWTK ++ + RI V
Sbjct: 13686 EAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD--MILKQDKRITIENVP 13743
Query: 1909 KNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVT 1961
K T+ I + D G Y+ A N+ G VV ++V + A DVT
Sbjct: 13744 KKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVT 13796
Score = 45.1 bits (105), Expect = 0.001
Identities = 44/184 (23%), Positives = 78/184 (42%), Gaps = 13/184 (7%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
++ G L C V + I W I + S+ S++ L I S +D
Sbjct: 3842 IVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVC---LEIFSFNSADV 3898
Query: 551 GLYQCIAQVRDEMDR---MVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
G Y+C+ V +E+ + M +L + P+ D + +G G++VTL
Sbjct: 3899 GEYECV--VANEVGKCGCMATHLLKEPPTFVKKVDDLIALG---GQTVTLQAAVRGSEPI 3953
Query: 608 HLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGIT 667
++W + + +I + + L IP VQ+S G Y C+A N+ G+ +VG
Sbjct: 3954 SVTW-MKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGS-QTSVGEL 4011
Query: 668 VTKK 671
+ K+
Sbjct: 4012 IVKE 4015
Score = 45.1 bits (105), Expect = 0.001
Identities = 122/536 (22%), Positives = 188/536 (35%), Gaps = 78/536 (14%)
Query: 2165 KLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFA---NGTLVVKSVTDKDAGDYLC 2221
+L G P P + W K+ D L + D+R+ V + N TL+V DAG Y
Sbjct: 20001 RLKIPIKGKPAPSVSW----KKGEDPLAT-DTRVSVESSAVNTTLIVYDCQKSDAGKYTI 20055
Query: 2222 VARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLP- 2280
+N G + + VV KP G +K D V + W+ P
Sbjct: 20056 TLKNVAGTKEGTISIKVVGKPG------------IPTGPIKFDEVTAEAMT--LKWAPPK 20101
Query: 2281 -DG--SLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYT--CFAENQVGKDEM 2335
DG + N ++ DS F + E +YT AEN+ G E
Sbjct: 20102 DDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE- 20160
Query: 2336 RVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNK-VIPTSSEK 2394
+ + P R+ + P ++V V ++ +TW P P +
Sbjct: 20161 ----GLKSEPIVARHPFDVPDAPPPPNIVDVRHDS-----VSLTWTDPKKTGGSPITGYH 20211
Query: 2395 YQIYQDGTLLIQKAQRSD---------------SGNYTCLVRNSAGEDRKTVWIHVNV-- 2437
+ + +LL ++A ++ + + N AG + ++ V
Sbjct: 20212 LEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVAL 20271
Query: 2438 -------QPPKINGNPNPITTV-REIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAP 2489
+P IN N +T + E G KL E P W V +P
Sbjct: 20272 DPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPEC 20331
Query: 2490 YYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKP-IFHDP- 2547
+ V G G + R K+ + + A +E E + + E P I DP
Sbjct: 20332 AFTVTDLVEG-GKYEFRIRAKNTAGAI--SAPSESTET-----IICKDEYEAPTIVLDPT 20383
Query: 2548 ISEKITAMAGHTISLNC-SAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGL 2606
I + +T AG TI LN S G P P W G D++ Q ML I
Sbjct: 20384 IKDGLTIKAGDTIVLNAISILGKPLPKSSW-SKAGKDIRPSDITQITSTPTSSMLTIKYA 20442
Query: 2607 SSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPP 2662
+ DAG Y A N G ++ +KV + +S ++ E L TPP
Sbjct: 20443 TRKDAGEYTITATNPFG--TKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPP 20496
Score = 45.1 bits (105), Expect = 0.001
Identities = 46/209 (22%), Positives = 81/209 (38%), Gaps = 20/209 (9%)
Query: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG--TLVIRKV 1918
+ ++V +++ C+ TG PKP V W + G + + R + K G L+I V
Sbjct: 30935 RNLNVRYQSNATLVCKVTGHPKPIVKWYR--QGKEIIADGLKYRIQEFKGGYHQLIIASV 30992
Query: 1919 QVQDRGQYMCTASN----LHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLA 1974
D Y A+N + G + V + + P+ L V G+ ++++
Sbjct: 30993 TDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEG-MGAVHALRGEVVSIKIPF 31051
Query: 1975 KGTPAPQISW-----IFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASN 2029
G P P I+W + + +Q + +T + D G Y A N
Sbjct: 31052 SGKPDPVITWQKGQDLIDNNGHYQVI------VTRSFTSLVFPNGVERKDAGFYVVCAKN 31105
Query: 2030 AAGADSLAIRLHVAALPPVIHQEKLENIS 2058
G D + L VA +P K+ ++S
Sbjct: 31106 RFGIDQKTVELDVADVPDPPRGVKVSDVS 31134
Score = 45.1 bits (105), Expect = 0.001
Identities = 58/287 (20%), Positives = 113/287 (39%), Gaps = 44/287 (15%)
Query: 1789 LLHTPQTTGSPSTNLQ----NIPMVSSTQSSIS---------FITSSVQSSGSFHQSSSK 1835
+L T + +G PS ++ N+P+ S+ SIS +SV SG + +K
Sbjct: 33151 VLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKY-TIKAK 33209
Query: 1836 FFAGGPPASK---FWSLGEKPQ---ILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTK 1889
F G A+ L E+P +L S T + + A+ + F +++
Sbjct: 33210 NFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSS 33269
Query: 1890 VSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQ 1949
S ++ +K ++ + + ++S+ G+ M L S T +
Sbjct: 33270 SSASSMTE----------MKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTSKM 33319
Query: 1950 --------PQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGR 2001
P + + D+++ G + + C G P P+++W R++ S +GR
Sbjct: 33320 LKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIH---SQEQGR 33376
Query: 2002 ITLHEN---RTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAAL 2045
+ TL I + D G+Y N G+DS + +H+ ++
Sbjct: 33377 FHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI 33423
Score = 44.7 bits (104), Expect = 0.001
Identities = 62/254 (24%), Positives = 93/254 (36%), Gaps = 26/254 (10%)
Query: 2242 PAKIEH-KEE-NDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTK 2299
P + H KEE + V Y + + C TG P P + W ++ + G
Sbjct: 30924 PIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEII--------ADGLKY 30975
Query: 2300 RYVVFNNG--TLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYL--- 2354
R F G L V + Y A NQ G ++V PA I L
Sbjct: 30976 RIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV-EVPAKIHLPKTLEGM 31034
Query: 2355 -AVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLI--QKAQRS 2411
AV G+VV++ G+P P +TW + + + + + T L+ +R
Sbjct: 31035 GAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERK 31094
Query: 2412 DSGNYTCLVRNSAGEDRKTVWIHVNVQPPKING-------NPNPITTVREIAAGGSRKLI 2464
D+G Y +N G D+KTV + V P G + T E A+ G K+
Sbjct: 31095 DAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKIT 31154
Query: 2465 DCKAEGIPTPRVLW 2478
+ E T W
Sbjct: 31155 NYIVEKCATTAERW 31168
Score = 44.3 bits (103), Expect = 0.002
Identities = 30/122 (24%), Positives = 54/122 (44%), Gaps = 4/122 (3%)
Query: 2524 GGEARLILQLTVLEPMEKPIFHDPIS---EKITAMAGHTISLNCSAAGTPTPSLVWVLPN 2580
G EA++ V P+E P+ + + +T + G +++L C +G P+P++ W +
Sbjct: 921 GREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYRED 980
Query: 2581 GTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEAN 2640
++S Q + L I + D+G + C A N AG L V + E
Sbjct: 981 -YQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFE 1039
Query: 2641 KQ 2642
K+
Sbjct: 1040 KE 1041
Score = 44.3 bits (103), Expect = 0.002
Identities = 55/240 (22%), Positives = 91/240 (37%), Gaps = 24/240 (10%)
Query: 427 AEPEWVMQPSIDIQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQ 486
A W S ++L ++T +Y Q S + T ++ + + EP ++
Sbjct: 4813 ARSVWKDDTSTSLELFAAKATDSG---TYICQLSNDVGTATSKA----TLFVKEPPQFIK 4865
Query: 487 RDQTVL---EGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIK 543
+ VL G C + + + W L DG+ + A S L++ +I
Sbjct: 4866 KPSPVLVLRNGQSTTFECQITGTPKIRVSWYL-DGNEITAIQKHGISFIDGLAT--FQIS 4922
Query: 544 SMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALA 603
+SG Y C A+ + V+ P T E V + K V L C
Sbjct: 4923 GARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKY--SDVELECEVTG 4980
Query: 604 IPEAHLSWILPNRRIINDLANTSHVYMLPNGT----LSIPKVQVSDSGYYRCVAVNQQGA 659
P ++W+ NR I +S Y L + L I K SD+G Y+C+ N+ G+
Sbjct: 4981 TPPFEVTWLKNNREI-----RSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGS 5035
Score = 44.3 bits (103), Expect = 0.002
Identities = 103/445 (23%), Positives = 162/445 (36%), Gaps = 61/445 (13%)
Query: 2023 YKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISL------------PPGLSIHIHCT 2070
++ +A NAAG A HV PV+ +++LE L G ++ +
Sbjct: 17187 FRVLAVNAAGESDPA---HVPE--PVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAI 17241
Query: 2071 AKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGT-LYIRNLAPKDSGRYECVAANLVG 2129
K P P V W D + P++ + V P G+ L IRN A +D G Y N G
Sbjct: 17242 IKGVPFPKVTWKKED--RDAPTK---ARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAG 17296
Query: 2130 SARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMID 2189
S +V++ V R S R D Y L D ++ +R
Sbjct: 17297 SKTVSVKVLVLDKPGPPRDLEVSEIRKDSCY-----LTWKEPLDDGGSVITNYVVERRDV 17351
Query: 2190 ALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVL--KVDVVMKPAKIEH 2247
A + + K + + + + A N+ G V K + P
Sbjct: 17352 ASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPG 17411
Query: 2248 KEENDHKVFYGGDLKVDCVATGLPNPEISWSLPD---GSLVNSFMQSDDSGGRTKRYVVF 2304
++ H V VD L W+ PD GS + ++ G T+ ++ F
Sbjct: 17412 PPKDLHHV------DVDKTEVSLV-----WNKPDRDGGSPITGYLVEYQEEG-TQDWIKF 17459
Query: 2305 NNGTLYFNEVGMREEGDYTCF---AENQVGKD------EMRVRVKVVTAPATIRNKTYLA 2355
T V ++G F AEN VG + + K+V + K
Sbjct: 17460 KTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEG 17519
Query: 2356 VQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDG---TLLIQKAQRSD 2412
+ V G V +G P+P W + +++ + E Y + D L I+ R D
Sbjct: 17520 LVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI--KTDEHYTVETDNFSSVLTIKNCLRRD 17577
Query: 2413 SGNYTCLVRNSAGEDRKTVWIHVNV 2437
+G Y V N+AG KTV +H+ V
Sbjct: 17578 TGEYQITVSNAAGS--KTVAVHLTV 17600
Score = 44.3 bits (103), Expect = 0.002
Identities = 99/474 (20%), Positives = 171/474 (36%), Gaps = 48/474 (10%)
Query: 1970 MECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASN 2029
+EC GT Q + I D + Q V G I +E R IK A+ G + +A +
Sbjct: 17840 VECQKPGTA--QWNRINKDELIRQCAFRVPGLIEGNEYR-FRIKAANIVGEGEPRELAES 17896
Query: 2030 AAGADSLAIRLHVAALPPVIHQEKL--ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGT 2087
D L PP + + + I++ G +I I K P P + W
Sbjct: 17897 VIAKDILH--------PPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKV 17948
Query: 2088 QIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV---QRAAA 2144
+R + + P L I+ D G+Y A N G A+ + +NV
Sbjct: 17949 LVREKRV--DLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQ 18006
Query: 2145 NARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANG 2204
N ++T + + + L D S + +R P+++ + S ++ + AN
Sbjct: 18007 NLKVTNVTKENCTISWENPL--DNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKAN- 18063
Query: 2205 TLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVD 2264
+ + + A NKVG + ++ I+ E ++ + D
Sbjct: 18064 ------LLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPEN--LHIADKGKT 18115
Query: 2265 CVATGLPNPEISWSLPDGSL-VNSFMQSDDSGGRTKR-------YVVFN--NGTLYFNEV 2314
V P+ P+ S V ++ D R + Y+V +Y V
Sbjct: 18116 FVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRV 18175
Query: 2315 GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEP 2374
+ EG + + + + V VK + K + V GD + + +G+P
Sbjct: 18176 QTKNEGGESDWVKTE------EVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKP 18229
Query: 2375 MPKVTWLSPTNKVIPTSSEKYQI---YQDGTLLIQKAQRSDSGNYTCLVRNSAG 2425
P+V W + T S + +I + KA+RSD G Y N+AG
Sbjct: 18230 FPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAG 18283
Score = 43.9 bits (102), Expect = 0.002
Identities = 45/176 (25%), Positives = 74/176 (42%), Gaps = 9/176 (5%)
Query: 485 VQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSS-GWLRIK 543
++ TVL+ V S SI W L D IL +D + S + S L+I+
Sbjct: 5054 IENTTTVLKSS-ATFQSTVAGSPPISITW-LKDDQILD---EDDNVYISFVDSVATLQIR 5108
Query: 544 SMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALA 603
S++ SG Y C A+ ++R +LVQ P+ + +V + + + +TL C
Sbjct: 5109 SVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEK--DPMTLECVVAG 5166
Query: 604 IPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
PE + W+ ++I+ S + + I V DSG Y N G+
Sbjct: 5167 TPELKVKWLKDGKQIVPS-RYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGS 5221
Score = 43.9 bits (102), Expect = 0.002
Identities = 79/351 (22%), Positives = 125/351 (35%), Gaps = 42/351 (11%)
Query: 2062 GLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPK----DS 2117
G + I +A P+P+V W DG +++ S L N + PK D+
Sbjct: 14401 GEKLSIPVPFRAVPVPTVSWHK-DGKEVKASDRL-----TMKNDHISAHLEVPKSVRADA 14454
Query: 2118 GRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPR 2177
G Y N +GSA A+ N ++ G D++ K C + +P P
Sbjct: 14455 GIYTITLENKLGSAT---------ASINVKVIGLPGPCKDIKASDITKSSCKLTWEP-PE 14504
Query: 2178 ILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDA---GDYL--CVARNKVGD-DY 2231
P + R + S T KD G+Y A NKVG +Y
Sbjct: 14505 FDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEY 14564
Query: 2232 VVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQS 2291
+ LK V+ + K D +V T P S G ++ +
Sbjct: 14565 IELKNPVIAQDPKQPPDPPVDVEVH--NPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKG 14622
Query: 2292 DDSGGRTKRYVVFNNGTLYFNEVGMREEGDYT--CFAENQVGKDEMR------VRVKVVT 2343
++ R ++V L + G+ E +Y AEN G E V +
Sbjct: 14623 EERWKRCNEHLV---PILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPID 14679
Query: 2344 APATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEK 2394
AP I + ++V GD + + G P P +TW+ N ++P +K
Sbjct: 14680 APKVILRTS---LEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKK 14727
Score = 43.9 bits (102), Expect = 0.002
Identities = 38/132 (28%), Positives = 50/132 (37%), Gaps = 9/132 (6%)
Query: 2318 EEGDYTCFAENQVGKDEMRVRVKVVTAPAT------IRNKTYLAVQVPYGDVVTVACEAK 2371
EE + A N G+ R V+ T +R V GD + V
Sbjct: 21031 EEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVL 21090
Query: 2372 GEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGE--DR 2428
G P P VTW + T ++ T+L I + RSDSG Y RN GE D
Sbjct: 21091 GRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDV 21150
Query: 2429 KTVWIHVNVQPP 2440
T+ +H PP
Sbjct: 21151 ITIQVHDIPGPP 21162
Score = 43.9 bits (102), Expect = 0.002
Identities = 88/423 (20%), Positives = 156/423 (36%), Gaps = 61/423 (14%)
Query: 2336 RVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKY 2395
R+ + A +R L VT+ KG P P+V W I T +
Sbjct: 25101 RIEPPEIELDADLRKVVVLRASATLRLFVTI----KGRPEPEVKWEKAEG--ILTDRAQI 25154
Query: 2396 QIYQDGTLL-IQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPIT-TVR 2453
++ T+L I R DSG Y + N++G KT +++V V ++ P+ T+R
Sbjct: 25155 EVTSSFTMLVIDNVTRFDSGRYNLTLENNSGS--KTAFVNVRV----LDSPSAPVNLTIR 25208
Query: 2454 EIAAG------------GSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGN- 2500
E+ G K+ + E T R +A T+ N
Sbjct: 25209 EVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYA----------------TITNNC 25252
Query: 2501 --GSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPM---EKPIFHDPISEKITAM 2555
+ I +L++ S +A NE G + L EP+ E P+ P + +
Sbjct: 25253 TKTTFRIENLQEGCSYYFRVLASNEYG---IGLPAETTEPVKVSEPPL--PPGRVTLVDV 25307
Query: 2556 AGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYR 2615
+T ++ + S + + ++ ISGL++ + +R
Sbjct: 25308 TRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFR 25367
Query: 2616 CVARNAAGHTER------LVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRF 2669
A N G ++ +++ + +KP +H ++ E LK+ G Q
Sbjct: 25368 VAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTF-NVKAREQLKIDVPFKGRPQATV 25426
Query: 2670 SWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVI 2729
+W +G L+ + S +L+++EAS D GTY + G I +IV+
Sbjct: 25427 NWR-KDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVL 25485
Query: 2730 AYP 2732
P
Sbjct: 25486 DRP 25488
Score = 43.5 bits (101), Expect = 0.003
Identities = 41/180 (22%), Positives = 70/180 (38%), Gaps = 14/180 (7%)
Query: 485 VQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKS 544
++ + V G +L C + S + W + + P D I S +++ +
Sbjct: 5429 LEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHEL---PASDKYRMTFIDSVAVIQMNN 5485
Query: 545 MEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
+ DSG + C AQ +V+V+ P + V KN V+L C
Sbjct: 5486 LSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNA--EVSLECELSGT 5543
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNG----TLSIPKVQVSDSGYYRCVAVNQQGAD 660
P + W R++ +S Y + + ++ I V SD G Y C A N+ G+D
Sbjct: 5544 PPFEVVWYKDKRQL-----RSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSD 5598
Score = 43.5 bits (101), Expect = 0.003
Identities = 29/87 (33%), Positives = 42/87 (48%), Gaps = 3/87 (3%)
Query: 1864 SVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDR 1923
SV D +G+PKP +TWTK G + TRI + L TL I++ D
Sbjct: 23240 SVQVGQDLKIEVPISGRPKPTITWTK--DGLPLKQTTRINVTDSLDLTTLSIKETHKDDG 23297
Query: 1924 GQYMCTASNLHGLDRMVVLLSVTVQQP 1950
GQY T +N+ G + + VT+ +P
Sbjct: 23298 GQYGITVANVVG-QKTASIEIVTLDKP 23323
Score = 43.5 bits (101), Expect = 0.003
Identities = 112/573 (19%), Positives = 201/573 (35%), Gaps = 82/573 (14%)
Query: 2106 TLYIRNLAPKDSGRYECVAANLVG-----SARRTVQLNVQRAAANARITGTSPRRTDVRY 2160
T + L K + A N G A +V + + A +TG + + +
Sbjct: 28602 TFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKA 28661
Query: 2161 GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFA---NGTLVVKSVTDKDAG 2217
G +D SG P P++ W+L R+ + R+ + TL VK D+G
Sbjct: 28662 GSPFTIDVPISGRPAPKVTWKLEEMRLKET-----DRVSITTTKDRTTLTVKDSMRGDSG 28716
Query: 2218 DYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISW 2277
Y N G + V V+ +P + G ++V V+ + +SW
Sbjct: 28717 RYFLTLENTAGVKTFSVTVVVIGRPGPVT------------GPIEVSSVSA--ESCVLSW 28762
Query: 2278 SLP-DG---SLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKD 2333
P DG + N ++ +SG + V N ++ ++ + Y ++ ++
Sbjct: 28763 GEPKDGGGTEITNYIVEKRESGTTAWQLV---NSSVKRTQIKVTHLTKYMEYSFRVSSEN 28819
Query: 2334 EMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSP----TNKVIP 2389
V + +AP + +V V+ A + W P +K+I
Sbjct: 28820 RFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAM-----SIRWEEPYHDGGSKIIG 28874
Query: 2390 TSSEKYQIYQDGTLLIQKAQRSD--SGNY--TCLVRNSAGEDRKTVWIHVNVQPPKINGN 2445
EK + T+L K + NY T LV + R V K +
Sbjct: 28875 YWVEK---KERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVS--KASEA 28929
Query: 2446 PNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPE--------GVVL---PAPYYGN- 2493
PI + A G ++ D T ++W+ P G ++ P G+
Sbjct: 28930 SRPIMAQNPVDAPGRPEVTDVTRS---TVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDG 28986
Query: 2494 -----RITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLT-------VLEPMEK 2541
T+ + + +L + D+ + +A+N G + T P +
Sbjct: 28987 RWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKA 29046
Query: 2542 PIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVL-PNGTDLQSGQQLQRFYHKADGM 2600
+ + +T AG + L+ + G P P ++W DL LQ +A +
Sbjct: 29047 ELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAV 29106
Query: 2601 LHISGLSSVDAGAYRCVARNAAGHTERLVSLKV 2633
+ S D+G Y +NA+G V +KV
Sbjct: 29107 IKFCDRS--DSGKYTLTVKNASGTKAVSVMVKV 29137
Score = 43.5 bits (101), Expect = 0.003
Identities = 130/651 (19%), Positives = 218/651 (33%), Gaps = 131/651 (20%)
Query: 2234 LKVDVVMKPAKIEHKEENDHKVFY--GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQS 2291
+KV +++ E E +F GG +++ G P P W+ +
Sbjct: 30125 VKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWT----------KEG 30174
Query: 2292 DDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNK 2351
D R + L E + G Y EN+ GK + ++V+V+ +P +
Sbjct: 30175 QDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGP 30234
Query: 2352 T-YLAVQVPY-------------GDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQI 2397
Y +QV D++ E + +PK W + ++V TS
Sbjct: 30235 LEYDDIQVRSVRVSWRPPADDGGADILGYILERR--EVPKAAWYTIDSRVRGTS------ 30286
Query: 2398 YQDGTLLIQKAQRSDSGNYTCLVRNSAG-----EDRKTVWIHVNVQPPKINGNPNPITTV 2452
L+++ + + ++ N G + + V + PP+ NP + V
Sbjct: 30287 -----LVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDV 30341
Query: 2453 REIAA----------GGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGS 2502
+ + GGSR + E T W + Y TV G
Sbjct: 30342 TKSSVSLSWSRPKDDGGSR-VTGYYIERKETSTDKWVRHNKTQITTTMY----TVTG--- 30393
Query: 2503 LDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF-HDPISEKITAMAGHTIS 2561
L Q +A+N+ G L+ P +P+ DP + +S
Sbjct: 30394 -----LVPDAEYQFRIIAQNDVG-------LSETSPASEPVVCKDPFDKPSQPGELEILS 30441
Query: 2562 LNCSAAGTPTPSLVWVLPN---GTDL--------QSGQQLQRFYHKA---DGMLHISGLS 2607
++ + +L W P G ++ QSG + +K D I GL
Sbjct: 30442 ISKDSV-----TLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLL 30496
Query: 2608 SVDAGAYRCVARNAAG-----HTERLVSLKV--GLKPEANKQYHNLVSIINGETLKLPCT 2660
+R A N G T + K+ G P K+ ++ + + GE +L C
Sbjct: 30497 EATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKL-GEAAQLSCQ 30555
Query: 2661 PPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPS 2720
G W G L + S TLTV D G Y C E G
Sbjct: 30556 IVGRPLPDIKW-YRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEV 30614
Query: 2721 VTSIPVIVIAYPPRITSEP-TPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGV 2779
TS +++ A P P Y G+T++L+ M +G P +TW
Sbjct: 30615 ETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTW------------ 30662
Query: 2780 QARLYGNRFLHPQGSLTIQHA------------TQRDAGFYKCMAKNILGS 2818
+G + L ++TI++ + AG YK N+ G+
Sbjct: 30663 ---FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGT 30710
Score = 43.5 bits (101), Expect = 0.003
Identities = 47/219 (21%), Positives = 86/219 (39%), Gaps = 22/219 (10%)
Query: 1850 GEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLK 1909
GE P I K + V+ C+ G+P P + W + + + +++++
Sbjct: 30530 GEAPGI-RKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQS-----RKYKMSS 30583
Query: 1910 NG---TLVIRKVQVQDRGQYMCTASNLHG--LDRMVVLLSVTVQQPQILASHYQDVTVY- 1963
+G TL + + +D G Y C A+N G +LL T PQ + Y
Sbjct: 30584 DGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQAT---PQFHPGYPLKEKYYG 30640
Query: 1964 -LGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGV 2022
+G T+ + + G P P ++W F +++ Q + T H + + G
Sbjct: 30641 AVGSTLRLHVMYIGRPVPAMTW-FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGK 30699
Query: 2023 YKCVASNAAGADSLAIRLHVAALP-----PVIHQEKLEN 2056
YK SN G + + + P P++ + L+N
Sbjct: 30700 YKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKN 30738
Score = 43.1 bits (100), Expect = 0.004
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 10/103 (9%)
Query: 2345 PATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLS-----PTNK---VIPTSSEKYQ 2396
P +I K ++ V+ G V + + KG P P +TW P NK + T K
Sbjct: 16117 PPSIDLKEFMEVEE--GTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLV 16174
Query: 2397 IYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP 2439
+ TL+I +++RSD+G YT N+ G K + ++V +P
Sbjct: 16175 VDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 16217
Score = 43.1 bits (100), Expect = 0.004
Identities = 43/179 (24%), Positives = 75/179 (41%), Gaps = 25/179 (13%)
Query: 2576 WVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTER-------L 2628
WV N TD+ Q ++GLS D +R +ARNA G +
Sbjct: 27900 WVRCNFTDVSECQYT------------VTGLSPGDRYEFRIIARNAVGTISPPSQSSGII 27947
Query: 2629 VSLKVGLKP--EANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLG 2686
++ + P E +Y + + I +GE+L++ G R +W +G+ +E +
Sbjct: 27948 MTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTW-FKDGVEIEKRMNME 28006
Query: 2687 RVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYT 2745
+L + +L VR+A+ RG Y + G + I V V P ++ P+ +T
Sbjct: 28007 ITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVG---PIRFT 28062
Score = 42.7 bits (99), Expect = 0.005
Identities = 34/120 (28%), Positives = 50/120 (41%), Gaps = 5/120 (4%)
Query: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPC 599
L I + D+G Y C ++ +E R V LV + + + G+SV+L C
Sbjct: 6043 LEILNSTKRDAGQYSC--EIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQC 6100
Query: 600 NALAIPEAHLSWILPNRRIINDLANTSHVYMLPN-GTLSIPKVQVSDSGYYRCVAVNQQG 658
PE +SW + ++ Y N TL KV ++DSG Y C A N G
Sbjct: 6101 QVAGTPEITVSWYKGDTKLRP--TPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIG 6158
Score = 42.7 bits (99), Expect = 0.005
Identities = 35/152 (23%), Positives = 61/152 (40%), Gaps = 14/152 (9%)
Query: 1904 RFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDV--- 1960
+F+ + N V+ +Q ++ A N+ GL + + Q+ + S DV
Sbjct: 17458 KFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLI 17517
Query: 1961 ---TVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENR---TLSIKE 2014
V G T+ + +G P P W + + T+ + L+IK
Sbjct: 17518 EGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI-----KTDEHYTVETDNFSSVLTIKN 17572
Query: 2015 ASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
D G Y+ SNAAG+ ++A+ L V +P
Sbjct: 17573 CLRRDTGEYQITVSNAAGSKTVAVHLTVLDVP 17604
Score = 42.7 bits (99), Expect = 0.005
Identities = 37/135 (27%), Positives = 65/135 (48%), Gaps = 6/135 (4%)
Query: 2603 ISGLSSVDAGAYRCVARNAAGHTE-RLVSLKVGLK----PEANKQYHNLVSIINGETLKL 2657
I+GL + ++R A+N G ++ R +S+ V K P A K N +++ GE LK+
Sbjct: 22108 ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKV 22167
Query: 2658 PCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEY 2717
G +W N + L+ + S +N LT+++A D G YV ++
Sbjct: 22168 DVPFIGRPTPAVTWHKDN-VPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSA 22226
Query: 2718 GPSVTSIPVIVIAYP 2732
G ++ ++ VIV+ P
Sbjct: 22227 GEAIETLNVIVLDKP 22241
Score = 42.4 bits (98), Expect = 0.007
Identities = 43/180 (23%), Positives = 66/180 (36%), Gaps = 14/180 (7%)
Query: 485 VQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKS 544
++ + +G QL C + S + W D + ++ + I S L I
Sbjct: 6370 LEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSF---INSVALLTINE 6426
Query: 545 MEPSDSGLYQCIAQ--VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNAL 602
DSG Y C A V D V TQ +G G V L C
Sbjct: 6427 ASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSP----VGALKGSDVILQCEIS 6482
Query: 603 AIPEAHLSWILPNRRIIND--LANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD 660
P + W+ +++ N TS + + +L I ++ SD G Y C A N+ G+D
Sbjct: 6483 GTPPFEVVWVKDRKQVRNSKKFKITSKHF---DTSLHILNLEASDVGEYHCKATNEVGSD 6539
Score = 42.4 bits (98), Expect = 0.007
Identities = 132/626 (21%), Positives = 218/626 (34%), Gaps = 97/626 (15%)
Query: 2265 CVATGLPNP--------EISWSLP---DGSLVNSFM--QSDDSGGRTKRYVVFNNGTLYF 2311
C G P P + W+ P GS++ ++ + D GR + N F
Sbjct: 23521 CDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQF 23580
Query: 2312 NEVGMREEGDYT--CFAENQVGKDEMRVRVKVVTAPATIRNKTYL-----------AVQV 2358
G+ E+ Y A+N G + T P T +++ L + V
Sbjct: 23581 TVSGLTEDQRYEFRVIAKNAAGAIS---KPSDSTGPITAKDEVELPRISMDPKFRDTIVV 23637
Query: 2359 PYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQK-AQRSDSGNYT 2417
G+ + + G+P+P + WL ++ ++ + + LLI K A R D G Y
Sbjct: 23638 NAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYI 23697
Query: 2418 CLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVRE----------IAAGGSRKLIDCK 2467
N AG V + V +P G P +T V + GGS +
Sbjct: 23698 LRASNVAGSKSFPVNVKVLDRPGPPEG-PVQVTGVTSEKCSLTWSPPLQDGGS-DISHYV 23755
Query: 2468 AEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEA 2527
E T R+ W V+ SL + L + + MA N+ G
Sbjct: 23756 VEKRETSRLAWTVVASEVV-------------TNSLKVTKLLEGNEYVFRIMAVNKYGVG 23802
Query: 2528 RLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPS-LVWVLPNGTDLQS 2586
+ VL + P S ++T +A ++++ + + S ++ + D +S
Sbjct: 23803 EPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRD-RS 23861
Query: 2587 GQQLQRFYHK--ADGMLHISGLSSVDAGAYRCVARNAAG------HTERLVSLKVGLKPE 2638
G + + + D L ++GL+ +R A NAAG T + KP
Sbjct: 23862 GIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPG 23921
Query: 2639 ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTL------PNGMHLEGPQTLGRVSLLD 2692
H + + N TL G + + + PQT RV+ +
Sbjct: 23922 PPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFE 23981
Query: 2693 NGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIV------IAYPPRITSEPTPVIYTR 2746
LT + + VC + TS+P V A + SE I R
Sbjct: 23982 ISKLTEHQ----EYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVVR 24037
Query: 2747 PGNTVKLNCMAMGIPKADITW-----ELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHAT 2801
G + +++ G P +ITW E DK ++ GV L+I +
Sbjct: 24038 AGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVN-----------YTQLSIDNCD 24086
Query: 2802 QRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ DAG Y +N GS S + V
Sbjct: 24087 RNDAGKYILKLENSSGSKSAFVTVKV 24112
Score = 42.0 bits (97), Expect = 0.009
Identities = 45/180 (25%), Positives = 73/180 (40%), Gaps = 9/180 (5%)
Query: 2052 EKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGT--LYI 2109
+ L+++ + G + P+P V W DG Q+ + L G F +G L I
Sbjct: 10 QPLQSVVVLEGSTATFEAHISGFPVPEVSW-FRDG-QVISTSTLPGVQISFSDGRAKLTI 67
Query: 2110 RNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCS 2169
+ +SGRY A N G A T +L V+ A T VR G ++L
Sbjct: 68 PAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMT-VRQGSQVRLQVR 126
Query: 2170 ASGDPWPRILWRLPSKRMIDAL-FSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG 2228
+G P P + + + +L F ++ +L++ +D+G Y A N VG
Sbjct: 127 VTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLY---SLLIAEAYPEDSGTYSVNATNSVG 183
Score = 42.0 bits (97), Expect = 0.009
Identities = 74/366 (20%), Positives = 120/366 (32%), Gaps = 53/366 (14%)
Query: 2507 SLRKSDSVQLVCMARNE-GGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHT---ISL 2562
+L K D +V AR GG R ++V + I P+S +I G +
Sbjct: 31528 TLIKKDLNMVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIMHAVGEEGGHVKY 31587
Query: 2563 NCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAA 2622
C + V L++ ++ + Y +L++ ++ +D G YRC N
Sbjct: 31588 VCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDY 31647
Query: 2623 GHTERLVSLKV-GLK---------------------------PEANKQYHNLVSIINGET 2654
G L V G++ PE +N + + GE
Sbjct: 31648 GEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYV-GEN 31706
Query: 2655 LKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGT--LTVREASVFDRGTYVCR 2712
++ T + +W G D G LT+ + D Y
Sbjct: 31707 VRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVV 31766
Query: 2713 METEYGPSVTSIPVIVIAYPPRITSEPTPVIYT-------RPGNTVKLNCMAMGIPKADI 2765
+YG + V +PP S P+ + G +V GIP +
Sbjct: 31767 ARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTL 31826
Query: 2766 TWELPDKSHLKAGVQARLYGNRFLHPQG----SLTIQHATQRDAGFYKCMAKNILGSDSK 2821
WE K G L N + +G +L I+ D G+Y+ A N GS S
Sbjct: 31827 KWE-------KDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSC 31879
Query: 2822 TTYIHV 2827
++ V
Sbjct: 31880 QAHLQV 31885
Score = 41.6 bits (96), Expect = 0.011
Identities = 34/139 (24%), Positives = 59/139 (42%), Gaps = 8/139 (5%)
Query: 2342 VTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQI-YQD 2400
+T A + +V V G T G P+P+V+W + ++ QI + D
Sbjct: 1 MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSD 60
Query: 2401 G--TLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAA- 2457
G L I +++SG Y+ N +G+ T + V + PN + ++ +
Sbjct: 61 GRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAE----TAPPNFVQRLQSMTVR 116
Query: 2458 GGSRKLIDCKAEGIPTPRV 2476
GS+ + + GIPTP V
Sbjct: 117 QGSQVRLQVRVTGIPTPVV 135
Score = 41.6 bits (96), Expect = 0.011
Identities = 43/181 (23%), Positives = 68/181 (37%), Gaps = 13/181 (7%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW---LRIKSMEPS 548
L+G L C + + + WV + + KF I S + L I ++E S
Sbjct: 6470 LKGSDVILQCEISGTPPFEVVWVKDRKQVRNS------KKFKITSKHFDTSLHILNLEAS 6523
Query: 549 DSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAE-KDTVTIGKNPGESVTLPCNALAIPEA 607
D G Y C A D V + P + DT T+ G++V L
Sbjct: 6524 DVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTL---IGDAVELRAIVEGFQPI 6580
Query: 608 HLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGIT 667
+ W+ +I + NT ++ TL + + S+SG Y C N G + +T
Sbjct: 6581 SVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLT 6640
Query: 668 V 668
V
Sbjct: 6641 V 6641
Score = 41.2 bits (95), Expect = 0.015
Identities = 42/150 (28%), Positives = 67/150 (44%), Gaps = 11/150 (7%)
Query: 2315 GMREEGDY--TCFAENQVGKDEMR-----VRVKVVTAPATIRNKTYLA--VQVPYGDVVT 2365
G+RE +Y FAENQ G + R V +K P I K + + V V G +
Sbjct: 26436 GLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLK 26495
Query: 2366 VACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDG-TLLIQKAQRSDSGNYTCLVRNSA 2424
V G+P+PKVT + T +I + T+ ++++ +D+G Y NS+
Sbjct: 26496 VDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEITAANSS 26555
Query: 2425 GEDRKTVWIHVNVQPPKINGNPNPITTVRE 2454
G + + I V +P G P I+ + E
Sbjct: 26556 GTTKAFINIVVLDRPGPPTG-PVVISDITE 26584
Score = 41.2 bits (95), Expect = 0.015
Identities = 33/130 (25%), Positives = 56/130 (43%), Gaps = 10/130 (7%)
Query: 2019 DRGVYKCVASNAAGA------DSLAIRLHVAALPPVIH--QEKLENISLPPGLSIHIHCT 2070
DR ++ +A NA G S I +PP++ E + + + G S+ I
Sbjct: 27922 DRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKAL 27981
Query: 2071 AKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGS 2130
+ P+P V W DG +I + V + +L++R+ G Y A N GS
Sbjct: 27982 VQGRPVPRVTW-FKDGVEIEKRMNMEIT-DVLGSTSLFVRDATRDHRGVYTVEAKNASGS 28039
Query: 2131 ARRTVQLNVQ 2140
A+ +++ VQ
Sbjct: 28040 AKAEIKVKVQ 28049
Score = 41.2 bits (95), Expect = 0.015
Identities = 22/95 (23%), Positives = 51/95 (53%), Gaps = 10/95 (10%)
Query: 1956 HYQDVTVYLGDTIAMECLAKGTPAPQISW----IFPDRRVWQTVSPVEGRITLHENRTLS 2011
++ + + G+++ ++ L +G P P+++W + ++R+ ++ V G + +L
Sbjct: 27964 YFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLG------STSLF 28017
Query: 2012 IKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
+++A+ RGVY A NA+G+ I++ V P
Sbjct: 28018 VRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTP 28052
Score = 41.2 bits (95), Expect = 0.015
Identities = 56/240 (23%), Positives = 83/240 (34%), Gaps = 34/240 (14%)
Query: 2286 NSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAP 2345
N F + S G T + V G G TC E K E+ R+
Sbjct: 28999 NFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLV- 29057
Query: 2346 ATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDG---T 2402
TIR + L + G G+P PK+ W ++ EK + G T
Sbjct: 29058 -TIRAGSDLVLDAAVG----------GKPEPKIIWTKGDKEL--DLCEKVSLQYTGKRAT 29104
Query: 2403 LLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIA------ 2456
+I+ RSDSG YT V+N++G +V + V P P TV +
Sbjct: 29105 AVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSP-----GPCGKLTVSRVTQEKCTL 29159
Query: 2457 ------AGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRK 2510
G ++ E T R+ W EG Y R+ + +R++ K
Sbjct: 29160 AWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNK 29219
Score = 41.2 bits (95), Expect = 0.015
Identities = 27/105 (25%), Positives = 46/105 (43%), Gaps = 14/105 (13%)
Query: 2356 VQVPYGDVVTVACEAKGEPMPKVTW----LSPTNKVIPTSSEKYQIYQDGTLLIQKAQRS 2411
V + G + + G P P +TW + ++ I ++E Y + L++ K R
Sbjct: 29456 VTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSL-----LIVDKVNRY 29510
Query: 2412 DSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIA 2456
D+G YT N +G+ TV + V P P P V+E++
Sbjct: 29511 DAGKYTIEAENQSGKKSATVLVKVYDTP-----GPCPSVKVKEVS 29550
Score = 40.8 bits (94), Expect = 0.019
Identities = 34/170 (20%), Positives = 65/170 (38%), Gaps = 11/170 (6%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW---LRIKSMEPS 548
L+ L C + + + W + + K+ I S + + I +++ S
Sbjct: 5529 LKNAEVSLECELSGTPPFEVVWYKDKRQLRSS------KKYKIASKNFHTSIHILNVDTS 5582
Query: 549 DSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAH 608
D G Y C AQ D V V ++ P ++ +++T+ GE L +
Sbjct: 5583 DIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVA--GEPAELQASIEGAQPIF 5640
Query: 609 LSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ W+ +I + N ++ TL K + +++G Y C N G
Sbjct: 5641 VQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGG 5690
Score = 40.8 bits (94), Expect = 0.019
Identities = 40/148 (27%), Positives = 67/148 (45%), Gaps = 12/148 (8%)
Query: 1907 VLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQ----PQILASHYQ--DV 1960
+ K + + +++ Q ++ A N GL V + +TV++ P++ S V
Sbjct: 27514 ISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQV 27573
Query: 1961 TVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENR-TLSIKEASFSD 2019
TV +G + +E KG P P ISW+ + ++ R + EN+ TLSIK A
Sbjct: 27574 TVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFV---RFSKTENKITLSIKNAKKEH 27630
Query: 2020 RGVYKCVASNAAGADSLAIRLHVAALPP 2047
G Y + NA +A+ + V L P
Sbjct: 27631 GGKYTVILDNA--VCRIAVPITVITLGP 27656
Score = 40.8 bits (94), Expect = 0.019
Identities = 30/122 (24%), Positives = 56/122 (45%), Gaps = 9/122 (7%)
Query: 1944 SVTVQQPQILASH------YQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSP 1997
SV +++PQI + Q +T G ++ G PAP+++W + R+ +T
Sbjct: 28635 SVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKET--D 28692
Query: 1998 VEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP-PVIHQEKLEN 2056
T + TL++K++ D G Y N AG + ++ + V P PV ++ +
Sbjct: 28693 RVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSS 28752
Query: 2057 IS 2058
+S
Sbjct: 28753 VS 28754
Score = 40.4 bits (93), Expect = 0.025
Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 13/199 (6%)
Query: 480 EPSGAVQR---DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILS 536
EP+ V++ Q + +G QL+C V + I W D I ++ + S
Sbjct: 4297 EPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKES---SKHRMSFVES 4353
Query: 537 SGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVT 596
+ LR+ + DSG Y C AQ D V+V+ E + + K V
Sbjct: 4354 TAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKE--YDVM 4411
Query: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHV--YMLPNGTLSIPKVQVSDSGYYRCVAV 654
L P ++W N + + + + +++ +L I K +D+G Y+C
Sbjct: 4412 LLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLV---SLQILKFVAADAGEYQCRVT 4468
Query: 655 NQQGADHFTVGITVTKKGS 673
N+ G+ + +T+ + S
Sbjct: 4469 NEVGSSICSARVTLREPPS 4487
Score = 40.4 bits (93), Expect = 0.025
Identities = 43/176 (24%), Positives = 66/176 (37%), Gaps = 24/176 (13%)
Query: 492 LEGGPCQLSCNVKASESPSIFWV-----LPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
L G + C V S S+ W + G + + D ++ L + +E
Sbjct: 7694 LSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTD--------NTCALTVNMLE 7745
Query: 547 PSDSGLYQCIAQVRDEMDRMVYRVLVQSPST---QPAEKDTVTIGKNPGESVTLPCNALA 603
SDSG Y CIA D + V+ P + +P D +T G +VT
Sbjct: 7746 ESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLT-----GTNVTFTSIVKG 7800
Query: 604 IPEAHLSWILPNRRII-NDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
P +SW + ++ D N S + L + V S SG Y C+ N+ G
Sbjct: 7801 TPPFSVSWFKGSSELVPGDRCNVSLEDSV--AELELFDVDTSQSGEYTCIVSNEAG 7854
Score = 40.4 bits (93), Expect = 0.025
Identities = 93/433 (21%), Positives = 157/433 (36%), Gaps = 86/433 (19%)
Query: 2161 GGTLKLDCSASGDPWPRILWRLPSKR---MIDALFSF--DSRIKVFANGT-LVVKSVTDK 2214
G +++ G P P+ W K M D + D++++ N + +++
Sbjct: 15825 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRS 15884
Query: 2215 DAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPE 2274
G Y A+NK G +V V+ P + DLKV + G +
Sbjct: 15885 HTGKYSITAKNKAGQKTANCRVKVMDVPGPPK-------------DLKVSDITRG--SCR 15929
Query: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN--------------GTLYFNEVGMREEG 2320
+SW +PD DD G R K YV+ G+ F + E
Sbjct: 15930 LSWKMPD----------DDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQ 15979
Query: 2321 DY--TCFAENQVGKDEMRVRVKVVTAPATIRNKTY---LAVQVPYGDVVTVACEAKGEPM 2375
Y AEN+ G ++ TA R+ Y +++ G + +P
Sbjct: 15980 QYFFRVRAENRFGIGPPVETIQRTTA----RDPIYPPDPPIKLKIGLITKNTVHLSWKP- 16034
Query: 2376 PKVTWLSPTNKVI-------PTSSEKYQIYQDGTLLIQKAQRS-----DSGNYTCLVR-- 2421
PK SP I PT ++K Q +++ Q + + G Y V+
Sbjct: 16035 PKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAV 16094
Query: 2422 NSAGEDRKTVWI-----HVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRV 2476
N+AG + + + PP I+ + E+ G + ++ K +G+P P +
Sbjct: 16095 NAAGVSKPSATVGPCDCQRPDMPPSID-----LKEFMEVEEGTNVNIV-AKIKGVPFPTL 16148
Query: 2477 LW--AFPEGVVLPAPY----YGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLI 2530
W A P+ P + N++ V +L I R+SD+ A N G A
Sbjct: 16149 TWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKE 16208
Query: 2531 LQLTVLEPMEKPI 2543
++L VL P+
Sbjct: 16209 MRLNVLGRPGPPV 16221
Score = 40.4 bits (93), Expect = 0.025
Identities = 33/124 (26%), Positives = 57/124 (45%), Gaps = 11/124 (8%)
Query: 2319 EGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKV 2378
EG+ AE+ + KD + V T R+ + V G + + KG P P +
Sbjct: 17887 EGEPRELAESVIAKDILHP--PEVELDVTCRD----VITVRVGQTIRILARVKGRPEPDI 17940
Query: 2379 TWLSPTNKVIPTSSEKYQIYQD---GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHV 2435
TW + KV+ ++ + QD L I++A R+D G Y +NS+G + + ++V
Sbjct: 17941 TW-TKEGKVL-VREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNV 17998
Query: 2436 NVQP 2439
+P
Sbjct: 17999 LDRP 18002
Score = 40.4 bits (93), Expect = 0.025
Identities = 52/196 (26%), Positives = 82/196 (41%), Gaps = 24/196 (12%)
Query: 2260 DLKVDCVATGLPNPEISWSLPD---GSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGM 2316
DLKV V+ + I W P GS + ++ D K V + +L ++ +
Sbjct: 19889 DLKVRSVSKS--SCSIGWKKPHSDGGSRIIGYVV-DFLTEENKWQRVMKSLSLQYSAKDL 19945
Query: 2317 REEGDYT--CFAENQVGK---DEMRV--RVKVVTAPATIRNKTYLAVQVPYGDVVTVACE 2369
E +YT AEN+ G+ E+ V R VV ++ L +
Sbjct: 19946 TEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIP 20005
Query: 2370 AKGEPMPKVTW------LSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNS 2423
KG+P P V+W L+ +V SS + TL++ Q+SD+G YT ++N
Sbjct: 20006 IKGKPAPSVSWKKGEDPLATDTRVSVESSAV-----NTTLIVYDCQKSDAGKYTITLKNV 20060
Query: 2424 AGEDRKTVWIHVNVQP 2439
AG T+ I V +P
Sbjct: 20061 AGTKEGTISIKVVGKP 20076
Score = 40.4 bits (93), Expect = 0.025
Identities = 102/491 (20%), Positives = 174/491 (35%), Gaps = 78/491 (15%)
Query: 1992 WQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP-PVIH 2050
W T +P G + + ++ + + ++ A N+ G A LP V+
Sbjct: 25049 WTTCTPPTGL----QGKQFTVTKLKENTEYNFRICAINSEGVGE------PATLPGSVVA 25098
Query: 2051 QEKLEN------------ISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGN 2098
QE++E + L ++ + T K P P V+W +G +Q +
Sbjct: 25099 QERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTS 25158
Query: 2099 LFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDV 2158
F L I N+ DSGRY N GS + A N R+ + ++
Sbjct: 25159 SFTM----LVIDNVTRFDSGRYNLTLENNSGS---------KTAFVNVRVLDSPSAPVNL 25205
Query: 2159 RYGGTLKLDCSASGDP-----WPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTD 2213
K + S +P +I + KR ++ + T ++++ +
Sbjct: 25206 TIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRK-AYATITNNCTKTTFRIENLQE 25264
Query: 2214 KDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNP 2273
+ + +A N+ G + PA+ + G +V V
Sbjct: 25265 GCSYYFRVLASNEYG----------IGLPAETTEPVKVSEPPLPPG--RVTLVDVTRNTA 25312
Query: 2274 EISWSLPD---GSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR--EEGDYTCFAEN 2328
I W P+ GS + ++ + G K TL G+ EE + A N
Sbjct: 25313 TIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVN 25372
Query: 2329 QVGKDEMR-VRVKVVTAPATIRNKTYL---AVQVPYGDVVTVACEAKGEPMPKVTW---- 2380
+ G+ + R + V V+ I+ L V + + + KG P V W
Sbjct: 25373 EKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDG 25432
Query: 2381 --LSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQ 2438
L T +V +SS+ +L I++A + D G Y V NSAG + I V +
Sbjct: 25433 QTLKETTRVNVSSSKTVT-----SLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDR 25487
Query: 2439 PPKINGNPNPI 2449
P G P PI
Sbjct: 25488 P----GPPGPI 25494
Score = 40.4 bits (93), Expect = 0.025
Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 2371 KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKT 2430
+G P P W P + + ++ + TL ++ R+D+G YT V N++G T
Sbjct: 28382 QGRPTPTAVWSKPDSN-LSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSIT 28440
Query: 2431 VWIHVNVQPPKINGNPNPITTVREIAAGGSRKLID 2465
+ V P G P PI T +++ G + + D
Sbjct: 28441 FTVKVLDTP----GPPGPI-TFKDVTRGSATLMWD 28470
Score = 40.4 bits (93), Expect = 0.025
Identities = 50/214 (23%), Positives = 84/214 (39%), Gaps = 25/214 (11%)
Query: 2262 KVDCVATGLPNPEISWSLP--DGS--LVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
K++ V ++W P DG L +++ +G VV T+ + V
Sbjct: 29640 KLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTSL 29699
Query: 2318 EEGDYTCF---AENQVGKDEMRVRVKVVTAP----------ATIRNKTYLAVQVPYGDVV 2364
EG+ F A+N+ G E R V VT +T+ KT + VP G V
Sbjct: 29700 NEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKT---IHVPAGRPV 29756
Query: 2365 TVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD-GTLLIQKAQRSDSGNYTCLVRNS 2423
+ G P P +W +K+ + + + L I++ D+G YT ++N
Sbjct: 29757 ELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNV 29816
Query: 2424 AGEDRKTVWIHVNVQPPKINGNPNPITTVREIAA 2457
G +T+ + + +P G P + EI A
Sbjct: 29817 TGTTSETIKVIILDKP----GPPTGPIKIDEIDA 29846
Score = 40.0 bits (92), Expect = 0.033
Identities = 46/182 (25%), Positives = 74/182 (40%), Gaps = 13/182 (7%)
Query: 1857 TKSPQTVSVTAETDTVFPCEATGKPKPFVTWTK----VSTGALMTPNTRIQRFEVLKNGT 1912
T+ Q+V V + F +G P P V+W + +ST L P +I +
Sbjct: 9 TQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTL--PGVQISFSD--GRAK 64
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQ-QPQILASHYQDVTVYLGDTIAME 1971
L I V + G+Y A+N G L V + P Q +TV G + ++
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 1972 CLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLH-ENRTLSIKEASFSDRGVYKCVASNA 2030
G P P + + R + S ++ +I+ + +L I EA D G Y A+N+
Sbjct: 125 VRVTGIPTPVVKFY---RDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNS 181
Query: 2031 AG 2032
G
Sbjct: 182 VG 183
Score = 40.0 bits (92), Expect = 0.033
Identities = 35/143 (24%), Positives = 64/143 (44%), Gaps = 14/143 (9%)
Query: 2318 EEGDYTCFAENQVG-----KDEMRVRVKVVTAPATIRNKTYLA--VQVPYGDVVTVACEA 2370
+E ++ A+NQVG + + ++ K + P I + V V G + +
Sbjct: 18571 QEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAIV 18630
Query: 2371 KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKT 2430
+G P PKVTW + + + L+I + R DSG Y+ + N AGE K
Sbjct: 18631 RGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGE--KA 18688
Query: 2431 VWIHVNVQPPKINGNPNPITTVR 2453
V+++V ++ P P++ ++
Sbjct: 18689 VFVNV-----RVLDTPGPVSDLK 18706
Score = 39.7 bits (91), Expect = 0.043
Identities = 49/184 (26%), Positives = 69/184 (37%), Gaps = 12/184 (6%)
Query: 480 EPSGAVQR--DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSS 537
EP+ V+R D +V G P L + S+ W+ + I ++ + S S
Sbjct: 6925 EPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQS---ERCSITMTEKS 6981
Query: 538 GWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPS--TQPAEKDTVTIGKNPGESV 595
L I D Y C+ + D V V P +P E IG E
Sbjct: 6982 TILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIG----EPA 7037
Query: 596 TLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVN 655
TL C PE +SW + ++ + A + +L I KV SD G Y C A N
Sbjct: 7038 TLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQ-FKNNVASLVINKVDHSDVGEYSCKADN 7096
Query: 656 QQGA 659
GA
Sbjct: 7097 SVGA 7100
Score = 39.7 bits (91), Expect = 0.043
Identities = 115/541 (21%), Positives = 178/541 (32%), Gaps = 104/541 (19%)
Query: 1938 RMVVLLSVTVQQPQILASHYQDVTVY-LGDTIAMECLAKGTPAPQISWIFPDRRVWQTVS 1996
R V++ T+ L YQ + + GD I +E G P P ++W D+ + QT
Sbjct: 21052 RPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQ- 21110
Query: 1997 PVEGRITLHENRT---LSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP-PVIHQE 2052
R+ T L+I E SD G Y A N G I + V +P P
Sbjct: 21111 ----RVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPI 21166
Query: 2053 KLENISL--------PP----GLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF 2100
K + +S PP G+ I + + S WV T IR +
Sbjct: 21167 KFDEVSSDFVTFSWDPPENDGGVPISNY-VVEMRQTDSTTWVELATTVIRTTY----KAT 21221
Query: 2101 VFPNGTLYIRNLAPKDSGRY--------ECVAANLVGSARRTVQLNVQRAAANARITGTS 2152
G Y K RY C+ AN V ++T +
Sbjct: 21222 RLTTGLEY--QFRVKAQNRYGVGPGITSACIVANY--------PFKVPGPPGTPQVTAVT 21271
Query: 2153 PRRTDVRY------GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTL 2206
+ + GG+ L ILW+ SK ++ +F + L
Sbjct: 21272 KDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPG--------NIFKSSGL 21323
Query: 2207 VVKSVTDKDAGDYLCVARNKVGDDYV------VLKVDVVMKPAKIEHKEENDHKVFYGGD 2260
TD A ++ +A N G +L +D + P K H V
Sbjct: 21324 -----TDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTV----- 21373
Query: 2261 LKVDCVATGLPNPEISWSLPD---GSLVNSFM--QSDDSGGRTKRYVVFNNGTLYFNEVG 2315
+ W+ P+ G + S++ + D GR + N F G
Sbjct: 21374 -------------TLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENEFTVSG 21420
Query: 2316 MREEGDYT--CFAENQVG--------KDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVT 2365
+ E+ Y A+N G D + R V + K V + G+
Sbjct: 21421 LTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFR 21480
Query: 2366 VACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQK-AQRSDSGNYTCLVRNSA 2424
+ + G P P + W ++ T+ + +I T L+ K + R DSG YT N
Sbjct: 21481 LEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPG 21540
Query: 2425 G 2425
G
Sbjct: 21541 G 21541
Score = 39.3 bits (90), Expect = 0.056
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 22/109 (20%)
Query: 1960 VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRT---------- 2009
+TV +G TI + KG P P I+W EG++ + E R
Sbjct: 17918 ITVRVGQTIRILARVKGRPEPDITW------------TKEGKVLVREKRVDLIQDLPRVE 17965
Query: 2010 LSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENIS 2058
L IKEA +D G Y A N++G + ++V P K+ N++
Sbjct: 17966 LQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVT 18014
Score = 38.9 bits (89), Expect = 0.073
Identities = 86/458 (18%), Positives = 170/458 (37%), Gaps = 74/458 (16%)
Query: 2129 GSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMI 2188
G +++ + + + ++ + R V GG +++ SG P P + W + + +
Sbjct: 16507 GEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLP 16566
Query: 2189 DALFSFDSRIKVFA-NGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEH 2247
++ I+ A + ++V+K+ G Y +A+N+ G+ + VDV+ P
Sbjct: 16567 Q-----EATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVP----- 16616
Query: 2248 KEENDHKVFYGGDLKVDCVATGLPNP--EISWSLPD----GSLVNSFMQSDDSGGRTKRY 2301
G + +A L N +++W P+ + N ++ +S R
Sbjct: 16617 -----------GPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTP 16665
Query: 2302 VVFNNGTLYFNEVGMREEGDY--TCFAENQVGKDEM--RVRVKVVTAPATIRNKTY-LAV 2356
V + G+ + Y AEN +G V+ P T+ + L V
Sbjct: 16666 VTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEV 16725
Query: 2357 QVPYGDVVTVACEAKGEPMPKVTWLSP--------TNKVIPT---SSEKYQIYQDGTLLI 2405
+ + VT +TW P N V+ + +EK+ + LL
Sbjct: 16726 KEVTKNTVT------------LTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLS 16773
Query: 2406 QK-----AQRSDSGNYTCLVRNSAGEDR-----KTVWIHVNVQPPKINGNPNPITTVREI 2455
+K + D+ Y N G+ + K + + PP ++ + T+R
Sbjct: 16774 RKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRV- 16832
Query: 2456 AAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQ 2515
G + + G P P+V W E VL + T +L+ ++SDS +
Sbjct: 16833 ---GEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIK-TTPATLALEKIKAKRSDSGK 16888
Query: 2516 LVCMARNEGGEARLILQLTVLE---PMEKPIFHDPISE 2550
+ N G + Q+ V++ P P+ D +++
Sbjct: 16889 YCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTK 16926
Score = 38.9 bits (89), Expect = 0.073
Identities = 47/200 (23%), Positives = 74/200 (37%), Gaps = 26/200 (13%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAG 2217
+R G T++L G P P+I W P+ + D + D + F + L ++V DAG
Sbjct: 19705 LRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRI-GLDIKSTDF-DTFLRCENVNKYDAG 19762
Query: 2218 DYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISW 2277
Y+ N G + V V+ P G + V + ++W
Sbjct: 19763 KYILTLENSCGKKEYTIVVKVLDTP---------------GPPVNVTVKEISKDSAYVTW 19807
Query: 2278 SLP--DGS--LVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDY--TCFAENQVG 2331
P DG ++N +Q D+ ++ V F + E Y FAEN+ G
Sbjct: 19808 EPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYG 19867
Query: 2332 ---KDEMRVRVKVVTAPATI 2348
E R VK P +
Sbjct: 19868 IGDPGETRDAVKASQTPGPV 19887
Score = 38.9 bits (89), Expect = 0.073
Identities = 99/454 (21%), Positives = 168/454 (37%), Gaps = 72/454 (15%)
Query: 2023 YKCVASNAAGADSLAIRLHVAALPPVIHQEKLEN------------ISLPPGLSIHIHCT 2070
++ A N AG H P+I +EKLE I++ G S+ +
Sbjct: 22911 FRICAINKAGVGE-----HADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVP 22965
Query: 2071 AKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVG- 2129
K P P V+W DG +IR + + +L + N+ DSG+Y N G
Sbjct: 22966 IKGRPTPEVKWGKVDG-EIRDAAIID---VTSSFTSLVLDNVNRYDSGKYTLTLENSSGT 23021
Query: 2130 -SARRTVQ-LNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRM 2187
SA TV+ L+ N ++T + + + L D +I + KR
Sbjct: 23022 KSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLL-------DGGSKIKNYIVEKRE 23074
Query: 2188 IDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEH 2247
S+ + + + + + + + + A N+ G D + K A++
Sbjct: 23075 ATRK-SYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPI-KVAEVPQ 23132
Query: 2248 KEENDHKVFYGGDLKVDCVATGLPNPEISWSLPD---GSLVNSF---MQSDDSGGRTKRY 2301
G + VD V + +SW+ P+ GS + + MQ+ S ++
Sbjct: 23133 PP---------GKITVDDVTRN--SVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECA 23181
Query: 2302 VVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMR-VRVKVVTAPATIR---NKTYLAVQ 2357
V + + N + EE + A N+ G+ + R + V +V I + +
Sbjct: 23182 RVKSLQAVITN-LTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYS 23240
Query: 2358 VPYGDVVTVACEAKGEPMPKVTW------LSPTNKVIPTSSEKYQIYQDGTLLIQKAQRS 2411
V G + + G P P +TW L T ++ T S TL I++ +
Sbjct: 23241 VQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLT-----TLSIKETHKD 23295
Query: 2412 DSGNYTCLVRNSAGEDRKTVWIHV----NVQPPK 2441
D G Y V N G+ KT I + PPK
Sbjct: 23296 DGGQYGITVANVVGQ--KTASIEIVTLDKPDPPK 23327
Score = 38.9 bits (89), Expect = 0.073
Identities = 82/389 (21%), Positives = 145/389 (37%), Gaps = 59/389 (15%)
Query: 2371 KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGT---LLIQKAQRSDSGNYTCLVRNSAGED 2427
KG P P++TW + ++K QI + L I R+D+G Y + NS+G
Sbjct: 24049 KGRPTPEITWSREEGEF----TDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGS- 24103
Query: 2428 RKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFP--EGVV 2485
K+ ++ V K+ P P + +A RK + ++W P +G
Sbjct: 24104 -KSAFVTV-----KVLDTPGP---PQNLAVKEVRK---------DSAFLVWEPPIIDGGA 24145
Query: 2486 LPAPY-----------YGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLT 2534
Y Y N + S + +L + MA NE G + +
Sbjct: 24146 KVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVD 24205
Query: 2535 VLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPS-----LVWVLPNGTDLQSGQQ 2589
++ E P P +T ++ + SL S +V + P GT+ S
Sbjct: 24206 AVKAAEPP--SPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVA 24263
Query: 2590 LQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTER------LVSLKVGLKPEANKQY 2643
+ + ++GLSS +R A N G ++ +++ + ++P +
Sbjct: 24264 ESKVCNAV-----VTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPF 24318
Query: 2644 HNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASV 2703
N SI GE LK+ G + SW + +G L+ + + L ++E +
Sbjct: 24319 -NTYSIQAGEDLKIEIPVIGRPRPNISW-VKDGEPLKQTTRVNVEETATSTVLHIKEGNK 24376
Query: 2704 FDRGTYVCRMETEYGPSVTSIPVIVIAYP 2732
D G Y G + ++ VIV+ P
Sbjct: 24377 DDFGKYTVTATNSAGTATENLSVIVLEKP 24405
Score = 38.9 bits (89), Expect = 0.073
Identities = 28/108 (25%), Positives = 53/108 (49%), Gaps = 4/108 (3%)
Query: 1941 VLLSVTVQQPQILASHYQDVTVYL--GDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPV 1998
VL+ ++ P+I ++ TVY+ G + ++ G P P+++ + D +
Sbjct: 26465 VLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVT-LSRDGVPLKATMRF 26523
Query: 1999 EGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
IT EN T+++KE+ +D G Y+ A+N++G I + V P
Sbjct: 26524 NTEITA-ENLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRP 26570
Score = 38.9 bits (89), Expect = 0.073
Identities = 48/190 (25%), Positives = 77/190 (40%), Gaps = 29/190 (15%)
Query: 2172 GDPWPRILWRLPSKRM-IDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD- 2229
G P P + WR K + DA +S ++ ++ L + VT D G Y+ N VG+
Sbjct: 27297 GRPPPTVTWRKDEKNLGSDARYSIEN---TDSSSLLTIPQVTRNDTGKYILTIENGVGEP 27353
Query: 2230 DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLP--DGS--LV 2285
+ V V+ PA + L+V V+ G + W P DG ++
Sbjct: 27354 KSSTVSVKVLDTPAACQ-------------KLQVKHVSRG--TVTLLWDPPLIDGGSPII 27398
Query: 2286 NSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGD--YTCFAENQVG---KDEMRVRVK 2340
N ++ D+ RT V + F + + E+ + AEN++G E VK
Sbjct: 27399 NYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVK 27458
Query: 2341 VVTAPATIRN 2350
PA IR+
Sbjct: 27459 AAEVPAPIRD 27468
Score = 38.9 bits (89), Expect = 0.073
Identities = 38/146 (26%), Positives = 54/146 (36%), Gaps = 28/146 (19%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAG 2217
VR GG ++L G P+P W + + S + LV+K D+G
Sbjct: 30148 VRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSE----THTELVIKEADRGDSG 30203
Query: 2218 DYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISW 2277
Y V NK G V +KV V+ P E E D D++V V +SW
Sbjct: 30204 TYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYD-------DIQVRSV-------RVSW 30249
Query: 2278 SLPDGSLVNSFMQSDDSGGRTKRYVV 2303
P +DD G Y++
Sbjct: 30250 RPP----------ADDGGADILGYIL 30265
Score = 38.5 bits (88), Expect = 0.095
Identities = 34/133 (25%), Positives = 57/133 (42%), Gaps = 10/133 (7%)
Query: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYR--VLVQSPSTQPAEKDTVTIGKNPGESVTL 597
L + + + +DSG Y C Q+ +++ + + V+ P + V + +N G+S T
Sbjct: 4825 LELFAAKATDSGTYIC--QLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRN-GQSTTF 4881
Query: 598 PCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNG--TLSIPKVQVSDSGYYRCVAVN 655
C P+ +SW L I A H +G T I +V +SG Y C A N
Sbjct: 4882 ECQITGTPKIRVSWYLDGNEIT---AIQKHGISFIDGLATFQISGARVENSGTYVCEARN 4938
Query: 656 QQGADHFTVGITV 668
G ++ + V
Sbjct: 4939 DAGTASCSIELKV 4951
Score = 38.5 bits (88), Expect = 0.095
Identities = 31/102 (30%), Positives = 50/102 (49%), Gaps = 4/102 (3%)
Query: 1947 VQQPQI-LASHYQD-VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITL 2004
V P+I + Y+D + V+ G++ ++ G P P I WI D+ + T +E + T
Sbjct: 22538 VDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTAR-LEIKSTD 22596
Query: 2005 HENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
+LS+K+A D G Y A N AG S+ + + V P
Sbjct: 22597 FAT-SLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 22637
Score = 38.5 bits (88), Expect = 0.095
Identities = 33/161 (20%), Positives = 70/161 (43%), Gaps = 12/161 (7%)
Query: 2275 ISWSLPD---GSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEG--DYTCFAENQ 2329
+SW+ PD GS++ ++ G + T ++E+ ++ FA+N+
Sbjct: 27481 LSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNE 27540
Query: 2330 VGKDE------MRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSP 2383
G + + V+ ++T + + V V G V + KG+P P ++WL
Sbjct: 27541 KGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKD 27600
Query: 2384 TNKVIPTSSEKYQIYQDG-TLLIQKAQRSDSGNYTCLVRNS 2423
+ + ++ ++ TL I+ A++ G YT ++ N+
Sbjct: 27601 GLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNA 27641
Score = 38.5 bits (88), Expect = 0.095
Identities = 24/83 (28%), Positives = 36/83 (43%), Gaps = 2/83 (2%)
Query: 1863 VSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQD 1922
V++ A +D V GKP+P + WTK + +Q K T VI+ D
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQ--YTGKRATAVIKFCDRSD 29114
Query: 1923 RGQYMCTASNLHGLDRMVVLLSV 1945
G+Y T N G + V++ V
Sbjct: 29115 SGKYTLTVKNASGTKAVSVMVKV 29137
Score = 38.1 bits (87), Expect = 0.12
Identities = 40/167 (23%), Positives = 66/167 (39%), Gaps = 12/167 (7%)
Query: 495 GPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQ 554
G C+L C + S + W DG + A D + + L I ++ +D+G +
Sbjct: 4128 GTCRLDCKIAGSLPMRVSW-FKDGKEIAA--SDRYRIAFVEGTASLEIIRVDMNDAGNFT 4184
Query: 555 CIAQVRDEMDRMVYRVLVQSPS---TQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSW 611
C A ++VQ P T+P KD + PG +V L + W
Sbjct: 4185 CRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVL-----PGSAVCLKSTFQGSTPLTIRW 4239
Query: 612 ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
N+ +++ + L + +L + V+ SDSG Y C N G
Sbjct: 4240 FKGNKELVSGGSCYITKEALES-SLELYLVKTSDSGTYTCKVSNVAG 4285
Score = 38.1 bits (87), Expect = 0.12
Identities = 47/206 (22%), Positives = 79/206 (38%), Gaps = 15/206 (7%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
E P + + PQ + D VF E K K V W + ++ + Q K
Sbjct: 12909 EIPVEIIRPPQDILEAPGADVVFLAELN-KDKVEVQWLR--NNMVVVQGDKHQMMSEGKI 12965
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAM 1970
L I ++ +D+G+Y A + ++ + + ++ QD+ V +G + M
Sbjct: 12966 HRLQICDIKPRDQGEYRFIAKDKEARAKLELAAAPKIKTAD------QDLVVDVGKPLTM 13019
Query: 1971 ECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNA 2030
P + W + + + ++ T E + I EA D+G YK V N
Sbjct: 13020 VVPYDAYPKAEAEWFKENEPL--STKTID---TTAEQTSFRILEAKKGDKGRYKIVLQNK 13074
Query: 2031 AGADSLAIRLHVAALP-PVIHQEKLE 2055
G I L V +P PV + E E
Sbjct: 13075 HGKAEGFINLKVIDVPGPVRNLEVTE 13100
Score = 38.1 bits (87), Expect = 0.12
Identities = 28/97 (28%), Positives = 43/97 (44%), Gaps = 6/97 (6%)
Query: 1951 QILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRI-TLHENRT 2009
Q+ AS + V+ G I + G P P ++W +R + P E I T + +
Sbjct: 16525 QLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTL-----PQEATIETTAISSS 16579
Query: 2010 LSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
+ IK S +GVY +A N AG I + V +P
Sbjct: 16580 MVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVP 16616
Score = 38.1 bits (87), Expect = 0.12
Identities = 87/389 (22%), Positives = 142/389 (36%), Gaps = 53/389 (13%)
Query: 2371 KGEPMPKVTW----LSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGE 2426
KG P P+VTW ++ N+ ++E + + L+I + R D+G + + N AG+
Sbjct: 20801 KGRPAPEVTWTKDNINLKNRANIENTESFTL-----LIIPECNRYDTGKFVMTIENPAGK 20855
Query: 2427 DRKTVWIHVNVQP-PKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVV 2485
V + V P P +N P IT + LID + R+ E
Sbjct: 20856 KSGFVNVRVLDTPGPVLNLRPTDITK-DSVTLHWDLPLIDGGS------RITNYIVEKRE 20908
Query: 2486 LPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH 2545
Y T + + L + MA NE G + EP E
Sbjct: 20909 ATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYG---------IGEPTETT--- 20956
Query: 2546 DPISEKITAMAGHTISLNCSAAGTPTPSLVWVLP--NGTDLQSGQQLQRFYHKADGMLHI 2603
+P+ K + SLN T SL W P +G +G ++ +D HI
Sbjct: 20957 EPV--KASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHI 21014
Query: 2604 S----------GLSSVDAGAYRCVARNAAGHTERLVSLKVGLK-----PEANKQ--YHNL 2646
+ L+ + ++ +A N+AG + S V +K PE + + Y L
Sbjct: 21015 TTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKL 21074
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDR 2706
V G+ +K+ G + +W + + L+ Q + + + L + E D
Sbjct: 21075 VIAKAGDNIKVEIPVLGRPKPTVTWKKGDQI-LKQTQRVNFETTATSTILNINECVRSDS 21133
Query: 2707 GTYVCRMETEYGP--SVTSIPVIVIAYPP 2733
G Y G V +I V I PP
Sbjct: 21134 GPYPLTARNIVGEVGDVITIQVHDIPGPP 21162
Score = 38.1 bits (87), Expect = 0.12
Identities = 35/140 (25%), Positives = 58/140 (41%), Gaps = 21/140 (15%)
Query: 540 LRIKSMEPSDSGLYQCIAQVRD-----EMDRMVYRVLVQSPS--TQPAEKDTVTIGKNPG 592
L IK D G+ CI++ ++ + D + + L +P+ +QP ++ N G
Sbjct: 33094 LTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNI-----NEG 33148
Query: 593 ESVTLPCNALAIPEAHLSWILPNRRIIND----LANTSHVYMLPNGTLSIPKVQVSDSGY 648
++V C P + W N I ++ + +VY +L I VSDSG
Sbjct: 33149 QNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVY-----SLEIRNASVSDSGK 33203
Query: 649 YRCVAVNQQGADHFTVGITV 668
Y A N +G T + V
Sbjct: 33204 YTIKAKNFRGQCSATASLMV 33223
Score = 37.7 bits (86), Expect = 0.16
Identities = 82/385 (21%), Positives = 136/385 (35%), Gaps = 59/385 (15%)
Query: 2363 VVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGT---LLIQKAQRSDSGNYTCL 2419
+ T CE EP KV W +V +KY+++ D L I SD+ +Y+C+
Sbjct: 2191 MATFECETS-EPFVKVKWYKDGMEV--HEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCV 2247
Query: 2420 VRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWA 2479
+ + N TT + I G + + + + I P
Sbjct: 2248 LVE----------------------DENVKTTAKLIVEGAVVEFVK-ELQDIEVPESYSG 2284
Query: 2480 FPEGVVLP----APYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQ--- 2532
E +V P +Y N + + NG I S R ++ + + + + GE ++
Sbjct: 2285 ELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGKK 2344
Query: 2533 ---LTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQ 2589
++P I +K+ G + L + + VW + +G ++Q +
Sbjct: 2345 TTCKLKMKPRPIAILQGLSDQKV--CEGDIVQLEVKVS-LESVEGVW-MKDGQEVQPSDR 2400
Query: 2590 LQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSL-KVGLKPEANKQYHNLVS 2648
+ K ML I ++ DAG Y T VS+ V + V+
Sbjct: 2401 VHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITPLKD-----VN 2455
Query: 2649 IINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGT---LTVREASVFD 2705
+I G L C W L + E + RV + GT L + D
Sbjct: 2456 VIEGTKAVLECKVSVPDVTSVKWYLND----EQIKPDDRVQAIVKGTKQRLVINRTHASD 2511
Query: 2706 RGTY---VCRMETEYGPSVTSIPVI 2727
G Y V R+ET SV I +I
Sbjct: 2512 EGPYKLIVGRVETNCNLSVEKIKII 2536
Score = 37.7 bits (86), Expect = 0.16
Identities = 34/123 (27%), Positives = 49/123 (39%), Gaps = 6/123 (4%)
Query: 2505 IRSLRKSDSVQLVCMARNEGGEARL--ILQLTVLEPMEKPIFHDPISEK--ITAMAGHTI 2560
++ +R+ +L A N GE +TV EP E P +S K I MAG T+
Sbjct: 15063 VKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTL 15122
Query: 2561 SLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARN 2620
+ G P P+ VW G + + K++ L I D G Y A N
Sbjct: 15123 RIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSE--LIIKDALRKDHGRYVITATN 15180
Query: 2621 AAG 2623
+ G
Sbjct: 15181 SCG 15183
Score = 37.7 bits (86), Expect = 0.16
Identities = 41/159 (25%), Positives = 65/159 (40%), Gaps = 18/159 (11%)
Query: 1960 VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSD 2019
+ V G+T +E G P P I W+ D+ + ++ + E + T L +K+A D
Sbjct: 23635 IVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEES-ARCEIKNT-DFKALLIVKDAIRID 23692
Query: 2020 RGVYKCVASNAAGADSLAIRLHVAALP-----PV----IHQEKLENISLPP---GLSIHI 2067
G Y ASN AG+ S + + V P PV + EK PP G S
Sbjct: 23693 GGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDIS 23752
Query: 2068 HCTAKAAPLPSVRWVLGDG----TQIRPSQFLHGNLFVF 2102
H + + W + ++ ++ L GN +VF
Sbjct: 23753 HYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVF 23791
Score = 37.7 bits (86), Expect = 0.16
Identities = 102/513 (19%), Positives = 181/513 (35%), Gaps = 80/513 (15%)
Query: 2164 LKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGT---LVVKSVTDKDAGDYL 2220
LK+D G P + WR + + + +R+ V ++ T L +K + +D G Y
Sbjct: 25412 LKIDVPFKGRPQATVNWRKDGQTLKET-----TRVNVSSSKTVTSLSIKEASKEDVGTYE 25466
Query: 2221 CVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLP 2280
N G V + + V+ +P G +++D V+ + ISW+ P
Sbjct: 25467 LCVSNSAGSITVPITIIVLDRPGP-------------PGPIRIDEVSCD--SITISWNPP 25511
Query: 2281 D---GSLVNSFMQSDDSGGRTKRYVVFN---NGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
+ G +++++ T ++V ++ + E + AEN+ GK
Sbjct: 25512 EYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRYGKSS 25571
Query: 2335 MRVRVKVVTA--------PATIR----NKTYLAV--QVPYGDVVT--VACEAKGEPMPKV 2378
VV P T + K+ + V QVP D + + + + +
Sbjct: 25572 YSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSI 25631
Query: 2379 TWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDR-----KTVWI 2433
W S NK++ ++ D L+ + Y N AG + + V
Sbjct: 25632 LW-SKANKILIADTQMKVSGLDEGLMYE---------YRVYAENIAGIGKCSKSCEPVPA 25681
Query: 2434 HVNVQPPKINGNPNPITTVRE-IAAGGSRKLID--CKAEGIPTPRVLWAFPEGVVLPAPY 2490
PP G P R+ ++ S+ D K G R P+G L Y
Sbjct: 25682 RDPCDPP---GQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERR--ELPDGRWLKCNY 25736
Query: 2491 YGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLT----VLEPMEKP--IF 2544
+ T ++ L + + ARN + T V + +E P +
Sbjct: 25737 TNIQETY-----FEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMM 25791
Query: 2545 HDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHIS 2604
+ I AG + +N AG P P + W +G +++ + + +L +
Sbjct: 25792 DVKFRDVIVVKAGEVLKINADIAGRPLPVISWA-KDGIEIEERARTEIISTDNHTLLTVK 25850
Query: 2605 GLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP 2637
D G Y +N AG V+ KV KP
Sbjct: 25851 DCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKP 25883
Score = 37.7 bits (86), Expect = 0.16
Identities = 87/399 (21%), Positives = 144/399 (36%), Gaps = 78/399 (19%)
Query: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGT---LYFNEV 2314
G D++V G P P ++W + +L G RY + N + L +V
Sbjct: 27286 GEDVQVLIPFKGRPPPTVTWRKDEKNL-----------GSDARYSIENTDSSSLLTIPQV 27334
Query: 2315 GMREEGDYTCFAENQVGKDEMR-VRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAK-- 2371
+ G Y EN VG+ + V VKV+ PA + L V+ VT+ +
Sbjct: 27335 TRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQK---LQVKHVSRGTVTLLWDPPLI 27391
Query: 2372 --GEPM----------PKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCL 2419
G P+ K TW ++K TS + + + + ++ G
Sbjct: 27392 DGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIG----- 27446
Query: 2420 VRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVL-W 2478
GE +T +P K P PI R+++ S K T +L W
Sbjct: 27447 ----IGEPCETT------EPVKAAEVPAPI---RDLSMKDSTK----------TSVILSW 27483
Query: 2479 AFPE--------GVVLPAPYYGNRITVHGNGS----LDIRSLRKSDSVQLVCMARNEGG- 2525
P+ V+ G + H S +++ L++ ++ A+NE G
Sbjct: 27484 TKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGL 27543
Query: 2526 -EARLILQLTVLEPMEKPI--FHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGT 2582
+ I +TV E + P D ++T GH + L G P PS+ W L +G
Sbjct: 27544 SDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISW-LKDGL 27602
Query: 2583 DLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNA 2621
L+ + ++ + L I G Y + NA
Sbjct: 27603 PLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNA 27641
Score = 37.7 bits (86), Expect = 0.16
Identities = 34/131 (25%), Positives = 54/131 (41%), Gaps = 9/131 (6%)
Query: 2614 YRCVARNAAGHTE-RLVSLKVGLKPEANKQYHNLVSIIN-------GETLKLPCTPPGAG 2665
+R A+N AG++E R V +K + +L I N G + G
Sbjct: 28616 FRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRP 28675
Query: 2666 QGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIP 2725
+ +W L M L+ + + D TLTV+++ D G Y +E G S+
Sbjct: 28676 APKVTWKLEE-MRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVT 28734
Query: 2726 VIVIAYPPRIT 2736
V+VI P +T
Sbjct: 28735 VVVIGRPGPVT 28745
Score = 37.7 bits (86), Expect = 0.16
Identities = 37/137 (27%), Positives = 54/137 (39%), Gaps = 18/137 (13%)
Query: 2701 ASVFDRGTYVCRME-TEYGPSVTSIPVIVIAYPPRI----TSEPTPVIYTRPGNTVKLNC 2755
ASV D V ++ T G SV+ + + P +I T E ++ G V +
Sbjct: 30990 ASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKI 31049
Query: 2756 MAMGIPKADITWE-----LPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKC 2810
G P ITW+ + + H + V + P G ++DAGFY
Sbjct: 31050 PFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSF--TSLVFPNG------VERKDAGFYVV 31101
Query: 2811 MAKNILGSDSKTTYIHV 2827
AKN G D KT + V
Sbjct: 31102 CAKNRFGIDQKTVELDV 31118
Score = 37.4 bits (85), Expect = 0.21
Identities = 32/114 (28%), Positives = 48/114 (42%), Gaps = 9/114 (7%)
Query: 2714 ETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKS 2773
ET P+ IPV PP + S V G +V L C G P +TW D
Sbjct: 928 ETARVPAPVEIPVT----PPTLVSGLKNVTVIE-GESVTLECHISGYPSPTVTWYREDYQ 982
Query: 2774 HLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+++ + ++ F L I+ A D+G + C A N G+ S + Y+ V
Sbjct: 983 -IESSIDFQI---TFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 1032
Score = 37.4 bits (85), Expect = 0.21
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 6/101 (5%)
Query: 2729 IAYPPRITSEPT--PVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGN 2786
I +PP + + T VI R G T+++ G P+ DITW K ++ + R+
Sbjct: 17902 ILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVR---EKRVDLI 17958
Query: 2787 RFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ L P+ L I+ A + D G Y AKN G + ++V
Sbjct: 17959 QDL-PRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNV 17998
Score = 37.4 bits (85), Expect = 0.21
Identities = 26/83 (31%), Positives = 35/83 (42%), Gaps = 2/83 (2%)
Query: 1863 VSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQD 1922
++V A T+ GKP P V+W K G L+ P I+ TL + V +D
Sbjct: 19305 LTVKAGTNVCLDATVFGKPMPTVSWKK--DGTLLKPAEGIKMAMQRNLCTLELFSVNRKD 19362
Query: 1923 RGQYMCTASNLHGLDRMVVLLSV 1945
G Y TA N G + L V
Sbjct: 19363 SGDYTITAENSSGSKSATIKLKV 19385
Score = 37.4 bits (85), Expect = 0.21
Identities = 39/195 (20%), Positives = 73/195 (37%), Gaps = 23/195 (11%)
Query: 2109 IRNLAPKDSGRYECVAANLVGSAR----RTVQLNVQRAAANARITGTSPRRTDVRYGGTL 2164
+RNL + ++ +A N G + R V + Q + G + + G +
Sbjct: 21024 VRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNI 21083
Query: 2165 KLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTD---KDAGDYLC 2221
K++ G P P + W+ D + R+ T + ++ + D+G Y
Sbjct: 21084 KVEIPVLGRPKPTVTWKKG-----DQILKQTQRVNFETTATSTILNINECVRSDSGPYPL 21138
Query: 2222 VARNKVGD--DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSL 2279
ARN VG+ D + ++V + P K + ++ D V PE +
Sbjct: 21139 TARNIVGEVGDVITIQVHDIPGPPTGPIKFD---------EVSSDFVTFSWDPPENDGGV 21189
Query: 2280 PDGSLVNSFMQSDDS 2294
P + V Q+D +
Sbjct: 21190 PISNYVVEMRQTDST 21204
Score = 37.4 bits (85), Expect = 0.21
Identities = 26/75 (34%), Positives = 40/75 (53%), Gaps = 8/75 (10%)
Query: 1975 KGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRT---LSIKEASFSDRGVYKCVASNAA 2031
KG P ++W R+ QT+ R+ + ++T LSIKEAS D G Y+ SN+A
Sbjct: 25419 KGRPQATVNW----RKDGQTLKETT-RVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSA 25473
Query: 2032 GADSLAIRLHVAALP 2046
G+ ++ I + V P
Sbjct: 25474 GSITVPITIIVLDRP 25488
Score = 37.4 bits (85), Expect = 0.21
Identities = 20/85 (23%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Query: 2361 GDVVTVACEAKGEPMPKVTWLSPTNKVIP-TSSEKYQIYQDGTLLIQKAQRSDSGNYTCL 2419
G+ + + +G P+P+VTW ++ + E + +L ++ A R G YT
Sbjct: 27973 GESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVE 28032
Query: 2420 VRNSAGEDRKTVWIHVNVQPPKING 2444
+N++G + + + V P K+ G
Sbjct: 28033 AKNASGSAKAEIKVKVQDTPGKVVG 28057
Score = 37.0 bits (84), Expect = 0.28
Identities = 36/151 (23%), Positives = 66/151 (43%), Gaps = 11/151 (7%)
Query: 2569 TPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERL 2628
+P+ ++ + +G++++ + + D LHI + DAG Y CV R G+ E+
Sbjct: 11143 SPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLR--LGNKEKT 11200
Query: 2629 VSLKV---GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTL 2685
+ K+ L K V+++ G+ L L C + W + +E P +
Sbjct: 11201 STAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCEL--NKERDVVWRKDGKIVVEKPGRI 11258
Query: 2686 --GRVSLLDNGTLTVREASVFDRGTYVCRME 2714
G + L+ LT+ +A D GTY +E
Sbjct: 11259 VPGVIGLM--RALTINDADDTDAGTYTVTVE 11287
Score = 37.0 bits (84), Expect = 0.28
Identities = 47/217 (21%), Positives = 84/217 (38%), Gaps = 29/217 (13%)
Query: 2205 TLVVKSVTDKDAGDYLCVARNKVGDDY------VVLKVDVVMKPAKIEHKEENDH-KVFY 2257
+ +V+++ + ++ A N++G+ VV++ D V K+ D KV
Sbjct: 15353 SFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKA 15412
Query: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG--TLYFNEVG 2315
G + + TGLP P+I WS + + D+ TK V + L +
Sbjct: 15413 GEPVHIPADVTGLPMPKIEWSKNE----TVIEKPTDALQITKEEVSRSEAKTELSIPKAV 15468
Query: 2316 MREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRN---------KTYLAVQVPY----GD 2362
++G YT A N++G V V+V P+ RN YL P +
Sbjct: 15469 REDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSE 15528
Query: 2363 VVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQ 2399
+ + + K W TN + ++Y I++
Sbjct: 15529 ITHYVIDKRDASRKKAEWEEVTNTAV---EKRYGIWK 15562
Score = 37.0 bits (84), Expect = 0.28
Identities = 26/85 (30%), Positives = 44/85 (51%), Gaps = 10/85 (11%)
Query: 2744 YTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGS-LTIQHATQ 2802
+ + G+T++L+ + G+P +TW+ D+ A +AR+ + P GS L I++A
Sbjct: 17229 HIKVGDTLRLSAIIKGVPFPKVTWKKEDRD---APTKARI----DVTPVGSKLEIRNAAH 17281
Query: 2803 RDAGFYKCMAKNILGSDSKTTYIHV 2827
D G Y +N G SKT + V
Sbjct: 17282 EDGGIYSLTVENPAG--SKTVSVKV 17304
Score = 37.0 bits (84), Expect = 0.28
Identities = 84/412 (20%), Positives = 139/412 (33%), Gaps = 77/412 (18%)
Query: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
GG ++ G P PEI+WS +G + +Q + T+ L +
Sbjct: 24039 GGSARIHIPFKGRPTPEITWSREEGEFTDK-VQIEKGVNYTQ---------LSIDNCDRN 24088
Query: 2318 EEGDYTCFAENQVGKDEMRVRVKVVTAPAT--------IRNKTYLAVQVPYGDVVTVACE 2369
+ G Y EN G V VKV+ P +R + V P ++ +
Sbjct: 24089 DAGKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEP--PIIDGGAK 24146
Query: 2370 AKGEPMPK-----VTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSA 2424
K + K + + ++K TS + + + + ++ G
Sbjct: 24147 VKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFG---------V 24197
Query: 2425 GEDRKTVWIHVNVQPPKINGNPNPITTVREIAA----------GGSRKLIDCKAEGIPTP 2474
G +TV +PP G +T V + +A GGSR ++ E P
Sbjct: 24198 GVPVETVDAVKAAEPPSPPGKVT-LTDVSQTSASLMWEKPEHDGGSR-VLGYVVEMQPKG 24255
Query: 2475 RVLWAF-PEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEAR----- 2528
W+ E V A G L Q A NE G++
Sbjct: 24256 TEKWSIVAESKVCNAVVTG---------------LSSGQEYQFRVKAYNEKGKSDPRVLG 24300
Query: 2529 ---LILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQ 2585
+ LT+ ++ P + AG + + G P P++ WV +G L+
Sbjct: 24301 VPVIAKDLTIQPSLKLPF------NTYSIQAGEDLKIEIPVIGRPRPNISWV-KDGEPLK 24353
Query: 2586 SGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKP 2637
++ +LHI + D G Y A N+AG +S+ V KP
Sbjct: 24354 QTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKP 24405
Score = 37.0 bits (84), Expect = 0.28
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 2/74 (2%)
Query: 1862 TVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQ 1921
T S+ A D G+P+P ++W K G + TR+ E + L I++
Sbjct: 24320 TYSIQAGEDLKIEIPVIGRPRPNISWVK--DGEPLKQTTRVNVEETATSTVLHIKEGNKD 24377
Query: 1922 DRGQYMCTASNLHG 1935
D G+Y TA+N G
Sbjct: 24378 DFGKYTVTATNSAG 24391
Score = 37.0 bits (84), Expect = 0.28
Identities = 29/98 (29%), Positives = 41/98 (41%), Gaps = 15/98 (15%)
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGT-----LLIQKAQRSD 2412
V G T+ +G P+P V W P + + + Y D T L I+ A R+D
Sbjct: 26198 VKAGASFTMTVPFRGRPVPNVLWSKPDTDL------RTRAYVDTTDSRTSLTIENANRND 26251
Query: 2413 SGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPIT 2450
SG YT ++N T+ + V P G P IT
Sbjct: 26252 SGKYTLTIQNVLSAASLTLVVKVLDTP----GPPTNIT 26285
Score = 37.0 bits (84), Expect = 0.28
Identities = 107/533 (20%), Positives = 193/533 (36%), Gaps = 77/533 (14%)
Query: 2240 MKPAKIEHKEENDHKVFY--GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGR 2297
++P +I+ K H V+ G +LKVD +G P P+++ S DG + + M R
Sbjct: 26471 LEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLS-RDGVPLKATM-------R 26522
Query: 2298 TKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVV------TAPATIRNK 2351
+ N T+ E + G Y A N G + + + V+ T P I +
Sbjct: 26523 FNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPVVISDI 26582
Query: 2352 TYLAVQVPY-------GDVVTVACEAKGEPMPKV-TWLSPT-----NKVIP-TSSEKYQI 2397
T +V + + G VT K E V T +S T KV+ T+ E+YQ
Sbjct: 26583 TEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMKLTTGEEYQF 26642
Query: 2398 YQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKIN-GNPNPITTVREIA 2456
+ DS T + + T W+ NV I G P++
Sbjct: 26643 RIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWV-TNVTRESITVGWHEPVSNGGSAV 26701
Query: 2457 AGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQL 2516
G ++ D + +LW +V+ ++ ++T G + +
Sbjct: 26702 VGYHLEMKDRNS-------ILWQKANKLVIRTTHF--KVTTISAGLI----------YEF 26742
Query: 2517 VCMARNEGG------EARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTP 2570
A N G + +L + EP P + +IT ++ +++SL+
Sbjct: 26743 RVYAENAAGVGKPSHPSEPVLAIDACEP--------PRNVRITDISKNSVSLSWQQPAFD 26794
Query: 2571 TPS-LVWVLPNGTDLQSGQQLQ-RFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTER- 2627
S + + DL G+ + F + + ISGL+ +R ARNA G
Sbjct: 26795 GGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNP 26854
Query: 2628 --------LVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHL 2679
+ G + +Y +V G ++KL G W + L
Sbjct: 26855 SEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEW-YKDDKEL 26913
Query: 2680 EGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYP 2732
+ + + D ++ +++A + G Y ++ G + +I V ++ P
Sbjct: 26914 QTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKP 26966
Score = 37.0 bits (84), Expect = 0.28
Identities = 32/129 (24%), Positives = 52/129 (40%), Gaps = 11/129 (8%)
Query: 2361 GDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD-GTLLIQKAQRSDSGNYTCL 2419
G V + G+P P + W ++ + + D ++LI+ A R +SG Y
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELK 26946
Query: 2420 VRNSAGEDRKTVWIHVNVQPPKINGNPNPITTV---------REIAAGGSRKLIDCKAEG 2470
+RN+ G T+ + + + P G P TV R A G K+ E
Sbjct: 26947 LRNAMGSASATIRVQI-LDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEK 27005
Query: 2471 IPTPRVLWA 2479
T RV+W+
Sbjct: 27006 RETSRVVWS 27014
Score = 36.6 bits (83), Expect = 0.36
Identities = 26/80 (32%), Positives = 33/80 (41%), Gaps = 8/80 (10%)
Query: 1862 TVSVTAETDTVFPCEATGKPKPFVTWTK------VSTGALMTPNTRIQRFEVLKNGTLVI 1915
T+ V A P + TG P P + W+K T AL + R E L I
Sbjct: 15407 TIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEA--KTELSI 15464
Query: 1916 RKVQVQDRGQYMCTASNLHG 1935
K +D+G Y TASN G
Sbjct: 15465 PKAVREDKGTYTVTASNRLG 15484
Score = 36.6 bits (83), Expect = 0.36
Identities = 23/85 (27%), Positives = 37/85 (43%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
+KP + K ++V A GKP P V WTK +T + R++ +
Sbjct: 18199 QKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADS 18258
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHG 1935
+ K + D G+Y+ TA+N G
Sbjct: 18259 SKFSLTKAKRSDGGKYVVTATNTAG 18283
Score = 36.6 bits (83), Expect = 0.36
Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 2/89 (2%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAG 2217
V G + K+D G P P I W + + + + + FA +L VK D+G
Sbjct: 22555 VHAGESFKVDADIYGKPIPTIQW-IKGDQELSNTARLEIKSTDFAT-SLSVKDAVRVDSG 22612
Query: 2218 DYLCVARNKVGDDYVVLKVDVVMKPAKIE 2246
+Y+ A+N G+ V + V V+ +P E
Sbjct: 22613 NYILKAKNVAGERSVTVNVKVLDRPGPPE 22641
Score = 36.6 bits (83), Expect = 0.36
Identities = 29/90 (32%), Positives = 38/90 (42%), Gaps = 14/90 (15%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWR-----LPSKRMIDALFSFDSRIKVFANGTLVVKSVT 2212
+R G +L+L S SG P P I W L S+ +ID S+ L+V V
Sbjct: 29458 IRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESY---------SLLIVDKVN 29508
Query: 2213 DKDAGDYLCVARNKVGDDYVVLKVDVVMKP 2242
DAG Y A N+ G + V V P
Sbjct: 29509 RYDAGKYTIEAENQSGKKSATVLVKVYDTP 29538
Score = 36.6 bits (83), Expect = 0.36
Identities = 33/123 (26%), Positives = 53/123 (43%), Gaps = 12/123 (9%)
Query: 553 YQC---IAQVRDEMDRMVYRVLVQSPS-TQPAEKDTVTIGKNPGESVTLPCNALAIPEAH 608
Y C + +++ D M R+L + P T P T +G+N VT+ + PE H
Sbjct: 31667 YYCRRTMKKIKRRTDTM--RLLERPPEFTLPLYNKTAYVGENVRFGVTITVH----PEPH 31720
Query: 609 LSWILPNRRIINDLANTSHVYMLPNGT--LSIPKVQVSDSGYYRCVAVNQQGADHFTVGI 666
++W ++I + + + G L+I V D Y VA N+ G D +
Sbjct: 31721 VTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKL 31780
Query: 667 TVT 669
TVT
Sbjct: 31781 TVT 31783
Score = 36.2 bits (82), Expect = 0.47
Identities = 49/205 (23%), Positives = 73/205 (35%), Gaps = 14/205 (6%)
Query: 2215 DAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPE 2274
DAG+Y CV R + K+ V P + E + V G L + C +
Sbjct: 11184 DAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELN--KERD 11241
Query: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
+ W DG +V + GR V+ L N+ + G YT EN E
Sbjct: 11242 VVWR-KDGKIV------VEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVEN-ANNLE 11293
Query: 2335 MRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEK 2394
VKVV K V AC+ + P + W +++ ++K
Sbjct: 11294 CSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDI-AKDTPNIKWFKGYDEIPAEPNDK 11352
Query: 2395 YQIYQDGT---LLIQKAQRSDSGNY 2416
+I +DG L I+ A D Y
Sbjct: 11353 TEILRDGNHLYLKIKNAMPEDIAEY 11377
Score = 36.2 bits (82), Expect = 0.47
Identities = 79/451 (17%), Positives = 148/451 (32%), Gaps = 92/451 (20%)
Query: 2230 DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFM 2289
D + +K +V +++ + V GG +++ +G P P ++W++ + +L
Sbjct: 16511 DVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEAT 16570
Query: 2290 QSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIR 2349
+ + ++ +G Y+ A+N+ G+ + + V V+ P +
Sbjct: 16571 IETTA----------ISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPV- 16619
Query: 2350 NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSP--------TNKVIPTSSEKYQIYQDG 2401
+LA ++ +C K+TW SP TN VI + +
Sbjct: 16620 GTPFLA-----HNLTNESC--------KLTWFSPEDDGGSPITNYVIEKRESDRRAWTPV 16666
Query: 2402 TLLIQKAQRSDSGN-------YTCLVRNSAG-----------------------EDRKTV 2431
T + + + G + NS G ED +
Sbjct: 16667 TYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVK 16726
Query: 2432 WIHVNV-----QPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVL 2486
+ N PPK +G I V E G+ K + +
Sbjct: 16727 EVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNL--------------- 16771
Query: 2487 PAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHD 2546
+ TV G D R S +V +V +G + +T + + P H
Sbjct: 16772 ----LSRKYTVKGLKEGDTYEYRVS-AVNIV----GQGKPSFCTKPITCKDELAPPTLHL 16822
Query: 2547 PISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGL 2606
+K+T G +L +G P P + W L+ + + + I
Sbjct: 16823 DFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAK 16882
Query: 2607 SSVDAGAYRCVARNAAGHTERLVSLKVGLKP 2637
S D+G Y V N+ G + + V +P
Sbjct: 16883 RS-DSGKYCVVVENSTGSRKGFCQVNVVDRP 16912
Score = 36.2 bits (82), Expect = 0.47
Identities = 120/588 (20%), Positives = 197/588 (33%), Gaps = 94/588 (15%)
Query: 2023 YKCVASNAAGADSL------AIRLHVAALPPVIHQEKL--ENISLPPGLSIHIHCTAKAA 2074
++ +A NAAG S AI PP I + + I + G S +
Sbjct: 22511 FRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGK 22570
Query: 2075 PLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRT 2134
P+P+++W+ GD ++ + L F +L +++ DSG Y A N+ G T
Sbjct: 22571 PIPTIQWIKGD-QELSNTARLEIKSTDFAT-SLSVKDAVRVDSGNYILKAKNVAGERSVT 22628
Query: 2135 VQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSF 2194
V + V + P V G C+ + W+ P + D
Sbjct: 22629 VNVKV--------LDRPGPPEGPVVISGVTAEKCT--------LAWKPP---LQDGGSDI 22669
Query: 2195 DSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHK 2254
+ I + +V +V D + C + + ++ V K E E
Sbjct: 22670 INYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVV 22729
Query: 2255 VFYGGDLKVDCVATGLPN-PEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN------- 2306
K V P PE++ D +V + D G YV+
Sbjct: 22730 A------KNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRW 22783
Query: 2307 --------GTLYFNEVGMREEGDY--TCFAENQVGKDEMRVRVKVVTA------------ 2344
G L G+ E DY AEN G E A
Sbjct: 22784 TRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNN 22843
Query: 2345 PATI---RNKTYLAVQVPYGDVVTVACEAKGEPMPK--VTWLSPTNKVIPTSSEKYQIYQ 2399
P I R+ +L+ P D CE +G + K V+ T PT K I
Sbjct: 22844 PKVIDITRSSVFLSWSKPIYD---GGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIE- 22899
Query: 2400 DGTLLIQKAQRSDSGNYTCLVRNSAGEDRKT-----VWIHVNVQPPKINGNPNPITTVRE 2454
++K N+ N AG + + ++ P I+ + + +
Sbjct: 22900 -----VEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLE-LRKIIN 22953
Query: 2455 IAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSV 2514
I AGGS +L +G PTP V W +G + A SL + ++ + DS
Sbjct: 22954 IRAGGSLRLF-VPIKGRPTPEVKWGKVDGEIRDAAIID---VTSSFTSLVLDNVNRYDSG 23009
Query: 2515 QLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISL 2562
+ N G + + VL+ P++ K+T + ++S+
Sbjct: 23010 KYTLTLENSSGTKSAFVTVRVLDTPS-----PPVNLKVTEITKDSVSI 23052
Score = 36.2 bits (82), Expect = 0.47
Identities = 32/149 (21%), Positives = 60/149 (40%), Gaps = 16/149 (10%)
Query: 2208 VKSVTDKDAGDYLCVARNKVG-------DDYVVLKVDVVMKPAKIEHKEENDHKVFYGGD 2260
V ++ D ++ +ARN VG +++ D + P E D + G+
Sbjct: 27915 VTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGE 27974
Query: 2261 -LKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREE 2319
L++ + G P P ++W DG + M + + V + +L+ +
Sbjct: 27975 SLRIKALVQGRPVPRVTW-FKDGVEIEKRMNMEITD-------VLGSTSLFVRDATRDHR 28026
Query: 2320 GDYTCFAENQVGKDEMRVRVKVVTAPATI 2348
G YT A+N G + ++VKV P +
Sbjct: 28027 GVYTVEAKNASGSAKAEIKVKVQDTPGKV 28055
Score = 35.8 bits (81), Expect = 0.62
Identities = 44/206 (21%), Positives = 70/206 (33%), Gaps = 32/206 (15%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILS---SGWLRIK 543
+D EG P + C V ++ + W D I P F + + L I
Sbjct: 3352 QDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKI------KPSRFFRMTQFEDTYQLEIA 3404
Query: 544 SMEPSDSGLYQCIA-----QVRDEM------------DRMVYRVLVQSPSTQPAEKDTVT 586
P D G Y +A QV +R+ + ++ + ++
Sbjct: 3405 EAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEP 3464
Query: 587 IGKNPGESVTLPCNALAIPEAHLSWILPNRRIIND--LANTSHVYMLPNGTLSIPKVQVS 644
+ G C + P W R I + S Y+ +L I + QV
Sbjct: 3465 LEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYI---SSLEILRTQVV 3521
Query: 645 DSGYYRCVAVNQQGADHFTVGITVTK 670
D G Y C A N+ G+ T +TVT+
Sbjct: 3522 DCGEYTCKASNEYGSVSCTATLTVTE 3547
Score = 35.8 bits (81), Expect = 0.62
Identities = 25/90 (27%), Positives = 41/90 (45%), Gaps = 8/90 (8%)
Query: 1960 VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLH---ENRTLSIKEAS 2016
+TV G I + G P P+I+W D + Q + RIT+ + T++I ++
Sbjct: 13700 LTVKAGTKIELPATVTGKPEPKITWTKADMILKQ-----DKRITIENVPKKSTVTIVDSK 13754
Query: 2017 FSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
SD G Y A N G + + ++V P
Sbjct: 13755 RSDTGTYIIEAVNVCGRATAVVEVNVLDKP 13784
Score = 35.8 bits (81), Expect = 0.62
Identities = 23/93 (24%), Positives = 40/93 (43%), Gaps = 4/93 (4%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P+IL P+ +++ A GKP P W K + + + + + + +
Sbjct: 18900 PKILM--PEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKAD--SSSI 18955
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSV 1945
L+I+ V +D G Y TA N G D + + V
Sbjct: 18956 LIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVV 18988
Score = 35.8 bits (81), Expect = 0.62
Identities = 109/503 (21%), Positives = 179/503 (35%), Gaps = 101/503 (20%)
Query: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
G ++KV+ G P P ++W D L + R + L NE
Sbjct: 21080 GDNIKVEIPVLGRPKPTVTWKKGDQILKQT--------QRVNFETTATSTILNINECVRS 21131
Query: 2318 EEGDYTCFAENQVGK--DEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAK---- 2371
+ G Y A N VG+ D + ++V + P T K D VT + +
Sbjct: 21132 DSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIK----FDEVSSDFVTFSWDPPENDG 21187
Query: 2372 GEPMPK----------VTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVR 2421
G P+ TW+ VI T+ + ++ T ++ R + N R
Sbjct: 21188 GVPISNYVVEMRQTDSTTWVELATTVIRTTYKATRL----TTGLEYQFRVKAQN-----R 21238
Query: 2422 NSAGEDRKTVWIHVNVQPPKINGNPNP--ITTV---------REIAAGGSRKLIDCKAEG 2470
G + I N P K+ G P +T V E + G ++ E
Sbjct: 21239 YGVGPGITSACIVANY-PFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVER 21297
Query: 2471 IPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLI 2530
+LW ++P GN G L + + +A N G+++
Sbjct: 21298 KERNGILWQTVSKALVP----GNIFKSSG--------LTDGIAYEFRVIAENMAGKSK-- 21343
Query: 2531 LQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGT-------- 2582
+P E + DPI G + LN + T +L W P T
Sbjct: 21344 ----PSKPSEPMLALDPIDPP-----GKPVPLNITRH---TVTLKWAKPEYTGGFKITSY 21391
Query: 2583 -----DLQSGQQLQ-RFYHKADGMLHISGLSSVDAGAYRCVARNAAG----HTERLVSLK 2632
DL +G+ L+ F + + +SGL+ A +R +A+NAAG +E ++
Sbjct: 21392 IVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAIT 21451
Query: 2633 VGLKPEANK-----QYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGR 2687
EA K ++ + V + GE +L G W+ +G LEG L
Sbjct: 21452 CRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWS-KDGKELEGTAKL-E 21509
Query: 2688 VSLLDNGT-LTVREASVFDRGTY 2709
+ + D T L ++++ D G Y
Sbjct: 21510 IKIADFSTNLVNKDSTRRDSGAY 21532
Score = 35.4 bits (80), Expect = 0.80
Identities = 40/197 (20%), Positives = 72/197 (36%), Gaps = 20/197 (10%)
Query: 480 EPSGAVQRDQT--VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSS 537
EP VQ+ VL G + VK + S+ W ++ + + S+
Sbjct: 7773 EPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAE- 7831
Query: 538 GWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTL 597
L + ++ S SG Y CI + +++P+ + +I K G+ + L
Sbjct: 7832 --LELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEK--GKPLIL 7887
Query: 598 PCNALAIPEAHLSW------ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRC 651
P ++W + P++R S + +P+ T V D+G Y C
Sbjct: 7888 EGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSST-------VEDAGQYNC 7940
Query: 652 VAVNQQGADHFTVGITV 668
N G D + I +
Sbjct: 7941 YIENASGKDSCSAQILI 7957
Score = 35.4 bits (80), Expect = 0.80
Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 8/88 (9%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRI---KVFANGTLVVKSVTDK 2214
V+ G ++L + +G P P+I W D + D RI V T+ +
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWT-----KADMILKQDKRITIENVPKKSTVTIVDSKRS 13756
Query: 2215 DAGDYLCVARNKVGDDYVVLKVDVVMKP 2242
D G Y+ A N G V++V+V+ KP
Sbjct: 13757 DTGTYIIEAVNVCGRATAVVEVNVLDKP 13784
Score = 35.4 bits (80), Expect = 0.80
Identities = 27/99 (27%), Positives = 41/99 (41%), Gaps = 2/99 (2%)
Query: 2535 VLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFY 2594
+L P E + D + + + AG T+ L G P P + W PN +L+ L
Sbjct: 19687 ILIPPEGELDAD-LRKTLILRAGVTMRLYVPVKGRPPPKITWSKPN-VNLRDRIGLDIKS 19744
Query: 2595 HKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV 2633
D L ++ DAG Y N+ G E + +KV
Sbjct: 19745 TDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKV 19783
Score = 35.4 bits (80), Expect = 0.80
Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 6/93 (6%)
Query: 2735 ITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGS 2794
I SE + + G + + G P ++ W PD ++ R Y + + S
Sbjct: 26188 IDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTD-----LRTRAYVDT-TDSRTS 26241
Query: 2795 LTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
LTI++A + D+G Y +N+L + S T + V
Sbjct: 26242 LTIENANRNDSGKYTLTIQNVLSAASLTLVVKV 26274
Score = 35.4 bits (80), Expect = 0.80
Identities = 29/99 (29%), Positives = 43/99 (43%), Gaps = 11/99 (11%)
Query: 1953 LASHYQDVTVY-LGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRT-- 2009
L Y +V Y G ++ + G PAP I W D+ + QT + EN T
Sbjct: 26874 LPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKEL-QT-----NALVCVENTTDL 26927
Query: 2010 --LSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
+ IK+A + G Y+ NA G+ S IR+ + P
Sbjct: 26928 ASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKP 26966
Score = 35.4 bits (80), Expect = 0.80
Identities = 40/173 (23%), Positives = 65/173 (37%), Gaps = 23/173 (13%)
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLN- 2138
RWV + T + Q+ + L+P D + +A N VG+ Q +
Sbjct: 27899 RWVRCNFTDVSECQYT-------------VTGLSPGDRYEFRIIARNAVGTISPPSQSSG 27945
Query: 2139 --VQRAAANARITGTSPRRTD---VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFS 2193
+ R I P D ++ G +L++ G P PR+ W K ++
Sbjct: 27946 IIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTW---FKDGVEIEKR 28002
Query: 2194 FDSRIK-VFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKI 2245
+ I V + +L V+ T G Y A+N G +KV V P K+
Sbjct: 28003 MNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKV 28055
Score = 35.4 bits (80), Expect = 0.80
Identities = 28/95 (29%), Positives = 38/95 (40%), Gaps = 5/95 (5%)
Query: 1953 LASHYQD-VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLS 2011
L YQ+ + V G I + KG P P W + Q +S T + L
Sbjct: 30138 LDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWT----KEGQDISKRAMIATSETHTELV 30193
Query: 2012 IKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
IKEA D G Y V N G ++ I++ V P
Sbjct: 30194 IKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSP 30228
Score = 35.0 bits (79), Expect = 1.1
Identities = 58/266 (21%), Positives = 97/266 (36%), Gaps = 22/266 (8%)
Query: 1862 TVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQ 1921
T S + +F C TW K + +P R K+ L I VQ+
Sbjct: 11127 TESEFVGSSAIFEC-LVSPSTAITTWMKDGSNIRESPKHRF--IADGKDRKLHIIDVQLS 11183
Query: 1922 DRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQ 1981
D G+Y C + L V + + + ++VTV G + + C +
Sbjct: 11184 DAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSC--ELNKERD 11241
Query: 1982 ISWIFPDRRVWQTVSPVEGRI---TLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAI 2038
+ W R+ + V GRI + R L+I +A +D G Y NA + +
Sbjct: 11242 VVW----RKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSC 11297
Query: 2039 RLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLG-DGTQIRP---SQF 2094
V + + + + P G +I AK P+++W G D P ++
Sbjct: 11298 VKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAK--DTPNIKWFKGYDEIPAEPNDKTEI 11355
Query: 2095 LHGNLFVFPNGTLYIRNLAPKDSGRY 2120
L ++ L I+N P+D Y
Sbjct: 11356 LRDGNHLY----LKIKNAMPEDIAEY 11377
Score = 35.0 bits (79), Expect = 1.1
Identities = 33/144 (22%), Positives = 62/144 (43%), Gaps = 9/144 (6%)
Query: 2597 ADGMLHISGLSSVDAGAYRCVARNAAGH------TERLVSLKVGLKPEANKQYHNL--VS 2648
A+ + ++GL AYR A N G TE + ++ PE L ++
Sbjct: 13642 AETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLT 13701
Query: 2649 IINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGT 2708
+ G ++LP T G + + +WT + M L+ + + ++ T+T+ ++ D GT
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWTKAD-MILKQDKRITIENVPKKSTVTIVDSKRSDTGT 13760
Query: 2709 YVCRMETEYGPSVTSIPVIVIAYP 2732
Y+ G + + V V+ P
Sbjct: 13761 YIIEAVNVCGRATAVVEVNVLDKP 13784
Score = 35.0 bits (79), Expect = 1.1
Identities = 23/103 (22%), Positives = 45/103 (43%), Gaps = 8/103 (7%)
Query: 1959 DVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITL---HENRTLSIKEA 2015
D+ V G+ +++ + P P +SW + V R+T+ H + L + ++
Sbjct: 14395 DIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEV-----KASDRLTMKNDHISAHLEVPKS 14449
Query: 2016 SFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENIS 2058
+D G+Y N G+ + +I + V LP K +I+
Sbjct: 14450 VRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDIT 14492
Score = 35.0 bits (79), Expect = 1.1
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 8/113 (7%)
Query: 2719 PSVTSIPVIVIA--YPPRITSEPT--PVIYTRPGNTVKLNCMAMGIPKADITWELPDKSH 2774
PS S PV ++A PPRI ++ + G V L+ G P ++W+ D +
Sbjct: 19277 PSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWK-KDGTL 19335
Query: 2775 LKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
LK ++ R L +L + ++D+G Y A+N GS S T + V
Sbjct: 19336 LKPAEGIKMAMQRNLC---TLELFSVNRKDSGDYTITAENSSGSKSATIKLKV 19385
Score = 35.0 bits (79), Expect = 1.1
Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 16/92 (17%)
Query: 2371 KGEPMPKVTWLSPTNKV-----IPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAG 2425
KG P PK+TW P + + S + D L + + D+G Y + NS G
Sbjct: 19718 KGRPPPKITWSKPNVNLRDRIGLDIKSTDF----DTFLRCENVNKYDAGKYILTLENSCG 19773
Query: 2426 EDRKTVWIHVNVQP-PKINGNPNPITTVREIA 2456
+ T+ + V P P +N TV+EI+
Sbjct: 19774 KKEYTIVVKVLDTPGPPVN------VTVKEIS 19799
Score = 35.0 bits (79), Expect = 1.1
Identities = 20/67 (29%), Positives = 30/67 (44%), Gaps = 2/67 (2%)
Query: 1879 GKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDR 1938
GKP P V+W K + +TR+ N TL++ Q D G+Y T N+ G
Sbjct: 20008 GKPAPSVSWKKGEDP--LATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKE 20065
Query: 1939 MVVLLSV 1945
+ + V
Sbjct: 20066 GTISIKV 20072
Score = 35.0 bits (79), Expect = 1.1
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 6/98 (6%)
Query: 2732 PPRITSEPT--PVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFL 2789
PPRI+ +P I G + K++ G P I W D+ L + + F
Sbjct: 22540 PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQE-LSNTARLEIKSTDFA 22598
Query: 2790 HPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
SL+++ A + D+G Y AKN+ G S T + V
Sbjct: 22599 T---SLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKV 22633
Score = 35.0 bits (79), Expect = 1.1
Identities = 38/174 (21%), Positives = 66/174 (37%), Gaps = 23/174 (13%)
Query: 2076 LPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTV 2135
LP RW T + +QF+ I L + A N VGS
Sbjct: 26809 LPDGRWTKASFTNVTETQFI-------------ISGLTQNSQYEFRVFARNAVGSISNPS 26855
Query: 2136 QLNVQRAAANAR---ITGTSPRRTDV---RYGGTLKLDCSASGDPWPRILWRLPSKRM-I 2188
++ ++ + T+V R G ++KL SG P P I W K +
Sbjct: 26856 EVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQT 26915
Query: 2189 DALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKP 2242
+AL ++ + ++++K ++G Y RN +G ++V ++ KP
Sbjct: 26916 NALVCVENTTDL---ASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKP 26966
Score = 35.0 bits (79), Expect = 1.1
Identities = 30/111 (27%), Positives = 46/111 (41%), Gaps = 15/111 (13%)
Query: 2717 YGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLK 2776
YG V +P+ E T V+ R G +VKL G P I W DK L+
Sbjct: 26867 YGGPVIDLPL-----------EYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDK-ELQ 26914
Query: 2777 AGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ L S+ I+ A + ++G Y+ +N +GS S T + +
Sbjct: 26915 TNALVCVENTTDL---ASILIKDADRLNSGCYELKLRNAMGSASATIRVQI 26962
Score = 35.0 bits (79), Expect = 1.1
Identities = 33/163 (20%), Positives = 60/163 (36%), Gaps = 16/163 (9%)
Query: 1887 WTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVT 1946
W KV+ A + + + + + + +G + +DR+ T
Sbjct: 28300 WHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRL------T 28353
Query: 1947 VQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHE 2006
+ I A+ Q V G +I + +G P P W PD S + R +H
Sbjct: 28354 APELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPD-------SNLSLRADIHT 28406
Query: 2007 N---RTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
TL+++ + +D G Y N +G+ S+ + V P
Sbjct: 28407 TDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTP 28449
Score = 35.0 bits (79), Expect = 1.1
Identities = 25/101 (24%), Positives = 36/101 (35%), Gaps = 10/101 (9%)
Query: 2245 IEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVF 2304
I+ + H V G +++ G P P WS PD +L R +
Sbjct: 28359 IDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNL----------SLRADIHTTD 28408
Query: 2305 NNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAP 2345
+ TL + G YT EN G + VKV+ P
Sbjct: 28409 SFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTP 28449
Score = 35.0 bits (79), Expect = 1.1
Identities = 24/91 (26%), Positives = 39/91 (42%), Gaps = 2/91 (2%)
Query: 1956 HYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEA 2015
H VT+ G + ++ G P P+I W D+ + V + T + T IK
Sbjct: 29053 HGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL-DLCEKVSLQYT-GKRATAVIKFC 29110
Query: 2016 SFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
SD G Y NA+G ++++ + V P
Sbjct: 29111 DRSDSGKYTLTVKNASGTKAVSVMVKVLDSP 29141
Score = 35.0 bits (79), Expect = 1.1
Identities = 24/85 (28%), Positives = 36/85 (42%), Gaps = 4/85 (4%)
Query: 1861 QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQV 1920
+TV++ A +G+P P +TW+K G + I E L++ KV
Sbjct: 29454 KTVTIRAGASLRLMVSVSGRPPPVITWSK--QGIDLASRAIIDTTE--SYSLLIVDKVNR 29509
Query: 1921 QDRGQYMCTASNLHGLDRMVVLLSV 1945
D G+Y A N G VL+ V
Sbjct: 29510 YDAGKYTIEAENQSGKKSATVLVKV 29534
Score = 34.7 bits (78), Expect = 1.4
Identities = 27/92 (29%), Positives = 41/92 (44%), Gaps = 6/92 (6%)
Query: 572 VQSPSTQPAEKDTVTIG-KN----PGESVTLPCNALAIPEAHLSWILPNRRIINDLANTS 626
V +P P T+ G KN GESVTL C+ P ++W + +I + + +
Sbjct: 932 VPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI-DFQ 990
Query: 627 HVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ L I + DSG + C AVN+ G
Sbjct: 991 ITFQSGIARLMIREAFAEDSGRFTCSAVNEAG 1022
Score = 34.7 bits (78), Expect = 1.4
Identities = 48/221 (21%), Positives = 74/221 (33%), Gaps = 56/221 (25%)
Query: 1758 VMRERKVIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPSTNLQ---NIPMVSSTQS 1814
V E PG ++ T H PP PP+ P+ T + ST ++ P +
Sbjct: 14976 VCAENAAGPGKFSPPSDPKTAHDPISPPGPPI---PRVTDTSSTTIELEWEPPAFNGGGE 15032
Query: 1815 SIS-FITSSVQSSGSFHQSSSKFF-------------------------AG-GPPASKFW 1847
+ F+ + + + + + K AG GPP
Sbjct: 15033 IVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPP----- 15087
Query: 1848 SLGEKPQILTKSPQT-------------VSVTAETDTVFPCEATGKPKPFVTWTKVSTGA 1894
GE + PQ + + A P TG+P P WTK G
Sbjct: 15088 --GETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTK-EEGE 15144
Query: 1895 LMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHG 1935
L R+ V L+I+ +D G+Y+ TA+N G
Sbjct: 15145 L--DKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCG 15183
Score = 34.7 bits (78), Expect = 1.4
Identities = 32/112 (28%), Positives = 50/112 (44%), Gaps = 10/112 (8%)
Query: 1945 VTVQQPQILASHYQDVTV------YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPV 1998
VTV +PQ + DV+V G T+ + + G P P W + + + +
Sbjct: 15093 VTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVI 15152
Query: 1999 EGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP-PVI 2049
+ T E L IK+A D G Y A+N+ G+ A R+ V +P PV+
Sbjct: 15153 DNVGTKSE---LIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVL 15201
Score = 34.7 bits (78), Expect = 1.4
Identities = 21/85 (24%), Positives = 34/85 (40%), Gaps = 3/85 (3%)
Query: 2161 GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYL 2220
G TL++ +G P P +W + D+ V L++K KD G Y+
Sbjct: 15119 GKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDN---VGTKSELIIKDALRKDHGRYV 15175
Query: 2221 CVARNKVGDDYVVLKVDVVMKPAKI 2245
A N G + +V+V P +
Sbjct: 15176 ITATNSCGSKFAAARVEVFDVPGPV 15200
Score = 34.7 bits (78), Expect = 1.4
Identities = 91/496 (18%), Positives = 169/496 (34%), Gaps = 77/496 (15%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFAN---GTLVVKSVTDK 2214
VR G T+++ G P P I W K ++ + R+ + + L +K
Sbjct: 17920 VRVGQTIRILARVKGRPEPDITWTKEGKVLVR-----EKRVDLIQDLPRVELQIKEAVRA 17974
Query: 2215 DAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPE 2274
D G Y+ A+N G V+V+ +P + +LKV V N
Sbjct: 17975 DHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQ-------------NLKVTNVTK--ENCT 18019
Query: 2275 ISWSLP---DGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDY--TCFAENQ 2329
ISW P GS + +F+ + +V ++ T + + +Y AEN+
Sbjct: 18020 ISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENK 18079
Query: 2330 VGKDEMRVRVKVVTAPATIRNKTYLAVQVPY---GDVVTVACEAKGEPMPKVTWLSP--- 2383
VG TI KT + P G+ + KG+ + W P
Sbjct: 18080 VG------------VGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYD 18127
Query: 2384 ---------TNKVIPTSSEKYQIY----QDGTLLIQKAQRSDSGNYTCLVRNSAGED--- 2427
+ + S + +++ ++ ++ + + + +N GE
Sbjct: 18128 GGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWV 18187
Query: 2428 -RKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVL 2486
+ V + ++Q P ++ + + TV+ G ++ G P P V W +
Sbjct: 18188 KTEEVVVKEDLQKPVLDLKLSGVLTVK----AGDTIRLEAGVRGKPFPEVAWTKDKDATD 18243
Query: 2487 PAPYYGNRITVHGNGS-LDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLE---PMEKP 2542
+I + S + ++SD + V A N G + VL+ P+
Sbjct: 18244 LTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNL 18303
Query: 2543 IFHDPISEKITAM------AGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHK 2596
D S++ T G N T +VW + T L G + R
Sbjct: 18304 KIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEG 18363
Query: 2597 ADGMLHISGLSSVDAG 2612
+ + + + + G
Sbjct: 18364 NEYIFRVRAENKIGTG 18379
Score = 34.7 bits (78), Expect = 1.4
Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 8/87 (9%)
Query: 1957 YQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHEN---RTLSIK 2013
+ +V +G + +E G P P I+W + QT RI + ++ TLSIK
Sbjct: 23236 FSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTT-----RINVTDSLDLTTLSIK 23290
Query: 2014 EASFSDRGVYKCVASNAAGADSLAIRL 2040
E D G Y +N G + +I +
Sbjct: 23291 ETHKDDGGQYGITVANVVGQKTASIEI 23317
Score = 34.3 bits (77), Expect = 1.8
Identities = 21/60 (35%), Positives = 28/60 (46%), Gaps = 7/60 (11%)
Query: 2362 DVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGT---LLIQKAQRSDSGNYTC 2418
D +T+ CE + V W +++P S KY I DG L I+KA D G Y C
Sbjct: 11678 DEITLKCEVSKDV--PVKWFKDGEEIVP--SPKYSIKADGLRRILKIKKADLKDKGEYVC 11733
Score = 34.3 bits (77), Expect = 1.8
Identities = 22/95 (23%), Positives = 38/95 (40%), Gaps = 9/95 (9%)
Query: 2254 KVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNE 2313
++ G L++ V TG P P W+ +G L + D+ G +++ L +
Sbjct: 15115 QIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSE---------LIIKD 15165
Query: 2314 VGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATI 2348
++ G Y A N G RV+V P +
Sbjct: 15166 ALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPV 15200
Score = 34.3 bits (77), Expect = 1.8
Identities = 85/389 (21%), Positives = 131/389 (33%), Gaps = 74/389 (19%)
Query: 2441 KINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFP--EGVVLPAPYYGNRITVH 2498
K + + +PI R I G K + T ++W P +G +P G +
Sbjct: 17787 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDG---GSPILGYVVECQ 17843
Query: 2499 GNGSLDIRSLRKSDSVQLVCMARN----EGGEARLILQLTVL----EPME-------KPI 2543
G+ + K + ++ C R EG E R ++ + EP E K I
Sbjct: 17844 KPGTAQWNRINKDELIRQ-CAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDI 17902
Query: 2544 FHDPISEK-------ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHK 2596
H P E IT G TI + G P P + W G L +++
Sbjct: 17903 LHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWT-KEGKVLVREKRVDLIQDL 17961
Query: 2597 ADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLK 2656
L I D G Y A+N++GH + + V +P G
Sbjct: 17962 PRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRP--------------GPCQN 18007
Query: 2657 LPCTPPGAGQGRFSWTLP--NG--------MHLEGPQTLGRVSLLDNGTLTVREASVFDR 2706
L T SW P NG + P G + + T + +A++
Sbjct: 18008 LKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLAN 18067
Query: 2707 GTYVCRMETE----YGPSV-TSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIP 2761
Y R+ E GP++ T P++ I P+ RPG L+ G
Sbjct: 18068 NEYYFRVCAENKVGVGPTIETKTPILAI----------NPI--DRPGEPENLHIADKGKT 18115
Query: 2762 KADITWELPD----KSHLKAGVQARLYGN 2786
+ W PD +L V+ RL G+
Sbjct: 18116 FVYLKWRRPDYDGGSPNLSYHVERRLKGS 18144
Score = 34.3 bits (77), Expect = 1.8
Identities = 42/179 (23%), Positives = 63/179 (35%), Gaps = 25/179 (13%)
Query: 2076 LPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARR-- 2133
LP RW+ T + +QF + L + +A N G+ +
Sbjct: 23562 LPDGRWMKASFTNVIETQFT-------------VSGLTEDQRYEFRVIAKNAAGAISKPS 23608
Query: 2134 --TVQLNVQRAAANARITGTSPRRTD---VRYGGTLKLDCSASGDPWPRILWRLPSKRMI 2188
T + + RI+ P+ D V G T +L+ G P P I W K +
Sbjct: 23609 DSTGPITAKDEVELPRIS-MDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIE 23667
Query: 2189 DALFSFDSRIK-VFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIE 2246
+ S IK L+VK D G Y+ A N G + V V+ +P E
Sbjct: 23668 E---SARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPE 23723
Score = 34.3 bits (77), Expect = 1.8
Identities = 24/88 (27%), Positives = 38/88 (43%), Gaps = 1/88 (1%)
Query: 1858 KSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRK 1917
K + V A V + GKP P V W+K L R++ ++ TLV++
Sbjct: 24712 KYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGK-ELEETAARMEIKSTIQKTTLVVKD 24770
Query: 1918 VQVQDRGQYMCTASNLHGLDRMVVLLSV 1945
D GQY+ SN+ G + + + V
Sbjct: 24771 CIRTDGGQYILKLSNVGGTKSIPITVKV 24798
Score = 33.9 bits (76), Expect = 2.3
Identities = 25/99 (25%), Positives = 42/99 (42%), Gaps = 6/99 (6%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P L + V+V C +G P P VTW + + + +I ++G
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQI----TFQSGI 997
Query: 1913 --LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQ 1949
L+IR+ +D G++ C+A N G L+V V +
Sbjct: 998 ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSE 1036
Score = 33.9 bits (76), Expect = 2.3
Identities = 33/146 (22%), Positives = 63/146 (43%), Gaps = 26/146 (17%)
Query: 2312 NEVGMREEGDYTCFAENQVGKD-EMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEA 2370
N +G+ E + +EN V KD + + + + T + L++ VP+ V
Sbjct: 14364 NAIGVSEPSE---ISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAV------- 14413
Query: 2371 KGEPMPKVTWLSPTNKVIPTSSEKYQIYQD---GTLLIQKAQRSDSGNYTCLVRNSAGED 2427
P+P V+W +V +S++ + D L + K+ R+D+G YT + N G
Sbjct: 14414 ---PVPTVSWHKDGKEV--KASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSA 14468
Query: 2428 RKTVWIHVNVQPPKINGNPNPITTVR 2453
++ + K+ G P P ++
Sbjct: 14469 TASINV-------KVIGLPGPCKDIK 14487
Score = 33.9 bits (76), Expect = 2.3
Identities = 27/101 (26%), Positives = 44/101 (43%), Gaps = 8/101 (7%)
Query: 1965 GDTIAMECLAKGTPAPQISWIFPDRRVWQTVS------PVEGRITLHENRT-LSIKEASF 2017
G I + + KG P P+ SW F D + + + P + ++ EN + + I E
Sbjct: 15825 GSQIRIPAVIKGRPTPKSSWEF-DGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKR 15883
Query: 2018 SDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENIS 2058
S G Y A N AG + R+ V +P K+ +I+
Sbjct: 15884 SHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDIT 15924
Score = 33.9 bits (76), Expect = 2.3
Identities = 23/85 (27%), Positives = 37/85 (43%), Gaps = 6/85 (7%)
Query: 2743 IYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQ 2802
+ + G TV+ + G+P W D S +K + + F LTI++ +
Sbjct: 17520 LVVKAGTTVRFPAIIRGVPVPTAKWTT-DGSEIKTDEHYTVETDNF---SSVLTIKNCLR 17575
Query: 2803 RDAGFYKCMAKNILGSDSKTTYIHV 2827
RD G Y+ N G SKT +H+
Sbjct: 17576 RDTGEYQITVSNAAG--SKTVAVHL 17598
Score = 33.9 bits (76), Expect = 2.3
Identities = 25/80 (31%), Positives = 31/80 (38%), Gaps = 14/80 (17%)
Query: 1975 KGTPAPQISW------IFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS 2028
KG PAP +SW + D RV S V N TL + + SD G Y
Sbjct: 20007 KGKPAPSVSWKKGEDPLATDTRVSVESSAV--------NTTLIVYDCQKSDAGKYTITLK 20058
Query: 2029 NAAGADSLAIRLHVAALPPV 2048
N AG I + V P +
Sbjct: 20059 NVAGTKEGTISIKVVGKPGI 20078
Score = 33.9 bits (76), Expect = 2.3
Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 3/100 (3%)
Query: 1960 VTVYLGDTIAMECLA-KGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFS 2018
+T+ GDTI + ++ G P P+ SW + + S + + + L+IK A+
Sbjct: 20388 LTIKAGDTIVLNAISILGKPLPKSSWSKAGKDI--RPSDITQITSTPTSSMLTIKYATRK 20445
Query: 2019 DRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENIS 2058
D G Y A+N G +++ V +P ++ N+S
Sbjct: 20446 DAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVS 20485
Score = 33.9 bits (76), Expect = 2.3
Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 2/85 (2%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAG 2217
VR G LK+D SG P P++ + A F++ I N T+ +K DAG
Sbjct: 26488 VRAGSNLKVDIPISGKPLPKVTLSRDGV-PLKATMRFNTEITA-ENLTINLKESVTADAG 26545
Query: 2218 DYLCVARNKVGDDYVVLKVDVVMKP 2242
Y A N G + + V+ +P
Sbjct: 26546 RYEITAANSSGTTKAFINIVVLDRP 26570
Score = 33.9 bits (76), Expect = 2.3
Identities = 24/86 (27%), Positives = 36/86 (41%), Gaps = 6/86 (6%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFAN-GTLVVKSVTDKDA 2216
VR G +++L + G P P +W P D+ S + I + TL V++ DA
Sbjct: 28369 VRAGASIRLFIAYQGRPTPTAVWSKP-----DSNLSLRADIHTTDSFSTLTVENCNRNDA 28423
Query: 2217 GDYLCVARNKVGDDYVVLKVDVVMKP 2242
G Y N G + V V+ P
Sbjct: 28424 GKYTLTVENNSGSKSITFTVKVLDTP 28449
Score = 33.5 bits (75), Expect = 3.1
Identities = 38/162 (23%), Positives = 69/162 (42%), Gaps = 28/162 (17%)
Query: 1903 QRFEVLKNGTLVIRKVQVQ-----DRGQYMCTASNLHGLDRMVVLLS-VTVQQ---PQIL 1953
++F + N L+ RK V+ D +Y +A N+ G + +T + P L
Sbjct: 16761 EKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTL 16820
Query: 1954 ASHYQD-VTVYLGDTIAMECLAKGTPAPQISW------IFPDRRVWQTVSPVEGRITLHE 2006
++D +T+ +G+ A+ G P P++SW + D R +P
Sbjct: 16821 HLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPA-------- 16872
Query: 2007 NRTLSIK--EASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
TL+++ +A SD G Y V N+ G+ +++V P
Sbjct: 16873 --TLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDRP 16912
Score = 33.5 bits (75), Expect = 3.1
Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 1879 GKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLV-IRKVQVQDRGQYMCTASNLHGLD 1937
G+PKP VTW K G + T+ FE T++ I + D G Y TA N+ G
Sbjct: 21091 GRPKPTVTWKK---GDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEV 21147
Query: 1938 RMVVLLSV 1945
V+ + V
Sbjct: 21148 GDVITIQV 21155
Score = 33.5 bits (75), Expect = 3.1
Identities = 27/109 (24%), Positives = 47/109 (43%), Gaps = 6/109 (5%)
Query: 1941 VLLSVTVQQPQILAS-HYQDVTVY-LGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPV 1998
+++ V+ P+++ ++DV V G+ + + G P P ISW + +
Sbjct: 25778 IIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEER---A 25834
Query: 1999 EGRITLHENRT-LSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
I +N T L++K+ D G Y N AG S+A+ V P
Sbjct: 25835 RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKP 25883
Score = 33.5 bits (75), Expect = 3.1
Identities = 20/67 (29%), Positives = 33/67 (49%), Gaps = 2/67 (2%)
Query: 2062 GLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYE 2121
G ++H+ K P PS+ W L DG ++ S+F+ + TL I+N + G+Y
Sbjct: 27578 GHNVHLELPYKGKPKPSISW-LKDGLPLKESEFVRFSK-TENKITLSIKNAKKEHGGKYT 27635
Query: 2122 CVAANLV 2128
+ N V
Sbjct: 27636 VILDNAV 27642
Score = 33.5 bits (75), Expect = 3.1
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 7/80 (8%)
Query: 2556 AGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM--LHISGLSSVDAGA 2613
AG +I L + G PTP+ VW P+ S L+ H D L + + DAG
Sbjct: 28371 AGASIRLFIAYQGRPTPTAVWSKPD-----SNLSLRADIHTTDSFSTLTVENCNRNDAGK 28425
Query: 2614 YRCVARNAAGHTERLVSLKV 2633
Y N +G ++KV
Sbjct: 28426 YTLTVENNSGSKSITFTVKV 28445
Score = 33.1 bits (74), Expect = 4.0
Identities = 37/187 (19%), Positives = 70/187 (37%), Gaps = 12/187 (6%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAP---MDDPDSKFSILSSGWLRIKSME 546
T G + C V + W ++ +P + D ++K L + ++
Sbjct: 3561 TTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHI------LELSNLT 3614
Query: 547 PSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPE 606
D G+Y C A + D +++ E + V N + V L C +
Sbjct: 3615 IQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAIN--KKVHLECQVDEDRK 3672
Query: 607 AHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGI 666
++W +++ + + TL IP ++ DSG Y C A N+ G+ + +
Sbjct: 3673 VTVTWSKDGQKLPPG-KDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATV 3731
Query: 667 TVTKKGS 673
TV + S
Sbjct: 3732 TVREPPS 3738
Score = 33.1 bits (74), Expect = 4.0
Identities = 37/139 (26%), Positives = 63/139 (45%), Gaps = 8/139 (5%)
Query: 1926 YMCTASNLHGL-DRMVVLLSVTVQ----QPQILASHYQD-VTVYLGDTIAMECLAKGTPA 1979
Y +A N G+ D +L +T +P + S ++D + V + + I + + G P
Sbjct: 13364 YRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPR 13423
Query: 1980 PQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIR 2039
P +W F D+ V +T V+ + TL L I + SD+G+Y N S I
Sbjct: 13424 PTATWCFGDK-VLETGDRVKMK-TLSAYAELVISPSERSDKGIYTLKLENRVKTISGEID 13481
Query: 2040 LHVAALPPVIHQEKLENIS 2058
++V A P + K +I+
Sbjct: 13482 VNVIARPSAPKELKFGDIT 13500
Score = 33.1 bits (74), Expect = 4.0
Identities = 61/251 (24%), Positives = 101/251 (40%), Gaps = 28/251 (11%)
Query: 2517 VCMARNEG-GEARLILQLTV----LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPT 2571
+C +EG GE + V +EP E + D + + + A T+ L + G P
Sbjct: 25078 ICAINSEGVGEPATLPGSVVAQERIEPPEIELDAD-LRKVVVLRASATLRLFVTIKGRPE 25136
Query: 2572 PSLVWVLPNG--TDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLV 2629
P + W G TD + F ML I ++ D+G Y N +G V
Sbjct: 25137 PEVKWEKAEGILTDRAQIEVTSSFT-----MLVIDNVTRFDSGRYNLTLENNSGSKTAFV 25191
Query: 2630 SLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGR-- 2687
+++V P A + + + +++ L PP G + N + +E +T +
Sbjct: 25192 NVRVLDSPSA--PVNLTIREVKKDSVTLSWEPPLIDGGA---KITNYI-VEKRETTRKAY 25245
Query: 2688 VSLLDNGTLTVREASVFDRG-TYVCRM--ETEYG---PSVTSIPVIVIAYPPRITSEPTP 2741
++ +N T T G +Y R+ EYG P+ T+ PV ++ PP T
Sbjct: 25246 ATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPV-KVSEPPLPPGRVTL 25304
Query: 2742 VIYTRPGNTVK 2752
V TR T+K
Sbjct: 25305 VDVTRNTATIK 25315
Score = 33.1 bits (74), Expect = 4.0
Identities = 32/110 (29%), Positives = 49/110 (44%), Gaps = 16/110 (14%)
Query: 2719 PSVTSIPVIVI--AYPPRITSEPT--PVIYTRPGNTVKLNCMAMGIPKADITWELPDKSH 2774
PS ++ P+IV PPR+ + VI + G +K+N G P I+W K
Sbjct: 25771 PSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWA---KDG 25827
Query: 2775 LKAGVQARLY----GNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDS 2820
++ +AR N L LT++ +RD G Y KN+ G+ S
Sbjct: 25828 IEIEERARTEIISTDNHTL-----LTVKDCIRRDTGQYVLTLKNVAGTRS 25872
Score = 33.1 bits (74), Expect = 4.0
Identities = 26/86 (30%), Positives = 39/86 (45%), Gaps = 4/86 (4%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLV-VKSVTDKDA 2216
V+ G LK++ +G P P I W +K I+ + I N TL+ VK +D
Sbjct: 25801 VKAGEVLKINADIAGRPLPVISW---AKDGIEIEERARTEIISTDNHTLLTVKDCIRRDT 25857
Query: 2217 GDYLCVARNKVGDDYVVLKVDVVMKP 2242
G Y+ +N G V + V+ KP
Sbjct: 25858 GQYVLTLKNVAGTRSVAVNCKVLDKP 25883
Score = 33.1 bits (74), Expect = 4.0
Identities = 24/85 (28%), Positives = 38/85 (44%), Gaps = 4/85 (4%)
Query: 1962 VYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRG 2021
V G + M +G P P + W PD + +T + V+ T +L+I+ A+ +D G
Sbjct: 26198 VKAGASFTMTVPFRGRPVPNVLWSKPDTDL-RTRAYVD---TTDSRTSLTIENANRNDSG 26253
Query: 2022 VYKCVASNAAGADSLAIRLHVAALP 2046
Y N A SL + + V P
Sbjct: 26254 KYTLTIQNVLSAASLTLVVKVLDTP 26278
Score = 33.1 bits (74), Expect = 4.0
Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 8/99 (8%)
Query: 1851 EKPQILTKS--PQTVSVTAETDTVFPCEATGKPKPFVTWTK--VSTGALMTPNTRIQRFE 1906
E P+I K+ TV V A ++ +GKP P VT ++ V A M NT I
Sbjct: 26472 EPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEI---- 26527
Query: 1907 VLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSV 1945
+N T+ +++ D G+Y TA+N G + + + V
Sbjct: 26528 TAENLTINLKESVTADAGRYEITAANSSGTTKAFINIVV 26566
Score = 33.1 bits (74), Expect = 4.0
Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 10/89 (11%)
Query: 573 QSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLP 632
++P + KD T GE+ L C + P + W R +L + M
Sbjct: 30531 EAPGIRKEMKDVTT---KLGEAAQLSCQIVGRPLPDIKWY----RFGKELIQSRKYKMSS 30583
Query: 633 NG---TLSIPKVQVSDSGYYRCVAVNQQG 658
+G TL++ + D G Y C+A N+ G
Sbjct: 30584 DGRTHTLTVMTEEQEDEGVYTCIATNEVG 30612
Score = 33.1 bits (74), Expect = 4.0
Identities = 23/83 (27%), Positives = 36/83 (43%), Gaps = 1/83 (1%)
Query: 587 IGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPN-GTLSIPKVQVSD 645
I + G+ +T+ C P ++W R+I + H+ + TL I VQ D
Sbjct: 33338 ISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQD 33397
Query: 646 SGYYRCVAVNQQGADHFTVGITV 668
G Y N+ G+D TV I +
Sbjct: 33398 GGLYTLSLGNEFGSDSATVNIHI 33420
Score = 32.7 bits (73), Expect = 5.2
Identities = 49/213 (23%), Positives = 84/213 (39%), Gaps = 22/213 (10%)
Query: 480 EPSGAVQRDQTV--LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSS 537
EP+ V++ ++V E P L C V + + W+ I+ + + ++ S
Sbjct: 5139 EPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVAS- 5197
Query: 538 GWLRIKSMEPSDSGLYQCIAQVRDEMDRM----VYRVLVQSPSTQPAEKDTVTIGKNPGE 593
RI+S+ DSG Y +V ++ RVL Q+ +K T + K G
Sbjct: 5198 --FRIQSVMKQDSGQYTF--KVENDFGSSSCDAYLRVLDQNIPPSFTKKLT-KMDKVLGS 5252
Query: 594 SVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLP----NGTLSIPKVQVSDSGYY 649
S+ + C W + I +TS Y L + +L + +++ D+ Y
Sbjct: 5253 SIHMECKVSGSLPISAQWFKDGKEI-----STSAKYRLVCHERSVSLEVNNLELEDTANY 5307
Query: 650 RCVAVNQQGADHFTVGITVTKKGSGLPSKRGRR 682
C N G D + GI K+ K GR+
Sbjct: 5308 TCKVSNVAGDDACS-GILTVKEPPSFLVKPGRQ 5339
Score = 32.7 bits (73), Expect = 5.2
Identities = 29/128 (22%), Positives = 48/128 (37%), Gaps = 11/128 (8%)
Query: 2023 YKCVASNAAGADSLAIRLHVAA----LPPVIHQE---KLENISLPPGLSIHIHCTAKAAP 2075
++ A N G ++ L+V +PP I + + I + G +HI P
Sbjct: 15367 FRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLP 15426
Query: 2076 LPSVRWVLGDGTQIRPSQFLHGNLFVFPNG----TLYIRNLAPKDSGRYECVAANLVGSA 2131
+P + W + +P+ L L I +D G Y A+N +GS
Sbjct: 15427 MPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSV 15486
Query: 2132 RRTVQLNV 2139
R V + V
Sbjct: 15487 FRNVHVEV 15494
Score = 32.7 bits (73), Expect = 5.2
Identities = 39/172 (22%), Positives = 68/172 (39%), Gaps = 22/172 (12%)
Query: 2182 LPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG--------DDYVV 2233
LP+ R + A FS + N V +T+ A ++ +A+N G D +
Sbjct: 21398 LPNGRWLKANFS-----NILEN-EFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAIT 21451
Query: 2234 LKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDD 2293
+ DV K++ K ++ + G +++ +G P P + WS DG + + +
Sbjct: 21452 CRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWS-KDGKELEGTAKLEI 21510
Query: 2294 SGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAP 2345
+V + T R+ G YT A N G + VKV+ P
Sbjct: 21511 KIADFSTNLVNKDST-------RRDSGAYTLTATNPGGFAKHIFNVKVLDRP 21555
Score = 32.7 bits (73), Expect = 5.2
Identities = 38/164 (23%), Positives = 64/164 (39%), Gaps = 26/164 (15%)
Query: 2023 YKCVASNAAGADSLAIRLHVAALPPVIHQEKLE--NISLPP----------GLSIHIHCT 2070
++ +A NAAGA I + P+ ++++E IS+ P G + +
Sbjct: 23593 FRVIAKNAAGA----ISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEAD 23648
Query: 2071 AKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGS 2130
PLP++ W+ GD +I S F L +++ D G+Y A+N+ GS
Sbjct: 23649 VHGKPLPTIEWLRGD-KEIEESARCEIKNTDF-KALLIVKDAIRIDGGQYILRASNVAGS 23706
Query: 2131 ARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDP 2174
V + V + P V+ G CS + P
Sbjct: 23707 KSFPVNVKV--------LDRPGPPEGPVQVTGVTSEKCSLTWSP 23742
Score = 32.7 bits (73), Expect = 5.2
Identities = 40/163 (24%), Positives = 67/163 (41%), Gaps = 16/163 (9%)
Query: 2583 DLQSGQQLQR-FYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGL------ 2635
DL G+ ++ F + + +SGL +R +ARNAAG+ +
Sbjct: 24643 DLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEI 24702
Query: 2636 -KPEA--NKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRV---S 2689
P A + +Y +++ + GET L G W+ +G LE +T R+ S
Sbjct: 24703 DAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWS-KDGKELE--ETAARMEIKS 24759
Query: 2690 LLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYP 2732
+ TL V++ D G Y+ ++ G I V V+ P
Sbjct: 24760 TIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRP 24802
Score = 32.7 bits (73), Expect = 5.2
Identities = 68/286 (23%), Positives = 93/286 (32%), Gaps = 54/286 (18%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILW---RLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDK 2214
VR G + L+ G P P I W LP K FS K TL +K+ +
Sbjct: 27575 VRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFS-----KTENKITLSIKNAKKE 27629
Query: 2215 DAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPE 2274
G Y + N V V + V + P+K + D ++K D V
Sbjct: 27630 HGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFD-------EIKADSVI------- 27675
Query: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKD- 2333
+SW +P+ D+ GG Y + T N + T F + KD
Sbjct: 27676 LSWDVPE----------DNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDA 27725
Query: 2334 EMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSE 2393
E + RV R + V P + VA P P P VI
Sbjct: 27726 EYQFRV---------RAENRYGVSQPLVSSIIVAKHQFRIPGP------PGKPVI----- 27765
Query: 2394 KYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP 2439
Y + DG L A D G+ E +W VN P
Sbjct: 27766 -YNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILWQKVNTSP 27810
Score = 32.7 bits (73), Expect = 5.2
Identities = 44/192 (22%), Positives = 70/192 (36%), Gaps = 38/192 (19%)
Query: 2597 ADGMLHISGLSSVDAGAYRCVARNAAG-------HTERLVSLKVGLKPEAN---KQYHNL 2646
+D ++ LS D +R +A+NAAG T + P+A + + +L
Sbjct: 28997 SDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDL 29056
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLG---RVSLLDNG---TLTVRE 2700
V+I G L L G + + WT +G + L +VSL G T ++
Sbjct: 29057 VTIRAGSDLVLDAAVGGKPEPKIIWT-------KGDKELDLCEKVSLQYTGKRATAVIKF 29109
Query: 2701 ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGI 2760
D G Y ++ G S+ V V+ PG KL +
Sbjct: 29110 CDRSDSGKYTLTVKNASGTKAVSVMVKVL---------------DSPGPCGKLTVSRVTQ 29154
Query: 2761 PKADITWELPDK 2772
K + W LP +
Sbjct: 29155 EKCTLAWSLPQE 29166
Score = 32.3 bits (72), Expect = 6.8
Identities = 30/97 (30%), Positives = 42/97 (43%), Gaps = 8/97 (8%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
+KP I+ P+ V V F C TG P+P V W G L+ + +RF V +
Sbjct: 1839 QKPDIVLY-PEPVRVLEGETARFRCRVTGYPQPKVNW--YLNGQLI---RKSKRFRVRYD 1892
Query: 1911 GT--LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSV 1945
G L I + D G+ TA N G+ V L +
Sbjct: 1893 GIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEI 1929
Score = 32.3 bits (72), Expect = 6.8
Identities = 25/90 (27%), Positives = 39/90 (43%), Gaps = 7/90 (7%)
Query: 2351 KTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIY---QDGTLLIQK 2407
K + V G + + G+P PK+TW +I ++ I + T+ I
Sbjct: 13695 KLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD--MILKQDKRITIENVPKKSTVTIVD 13752
Query: 2408 AQRSDSGNYTCLVRNSAGEDRKTVWIHVNV 2437
++RSD+G Y N G R T + VNV
Sbjct: 13753 SKRSDTGTYIIEAVNVCG--RATAVVEVNV 13780
Score = 32.3 bits (72), Expect = 6.8
Identities = 39/171 (22%), Positives = 71/171 (41%), Gaps = 23/171 (13%)
Query: 1887 WTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVT 1946
W K +TG + RI +F V+ +Q +++ + +A N G+ V+ V
Sbjct: 20719 WIKDTTGTAL----RITQF--------VVPDLQTKEKYNFRISAINDAGVGEPAVIPDVE 20766
Query: 1947 VQQPQILASHYQD------VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEG 2000
+ + ++ D + V G +I + KG PAP+++W D + + +E
Sbjct: 20767 IVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWT-KDNINLKNRANIEN 20825
Query: 2001 RITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP-PVIH 2050
+ L I E + D G + N AG S + + V P PV++
Sbjct: 20826 TESF---TLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLN 20873
Score = 32.3 bits (72), Expect = 6.8
Identities = 23/87 (26%), Positives = 39/87 (44%), Gaps = 6/87 (6%)
Query: 2742 VIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHAT 2801
++ + G+ +K+ +G PK +TW+ D+ LK Q + L I
Sbjct: 21074 LVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQI-LK---QTQRVNFETTATSTILNINECV 21129
Query: 2802 QRDAGFYKCMAKNILG--SDSKTTYIH 2826
+ D+G Y A+NI+G D T +H
Sbjct: 21130 RSDSGPYPLTARNIVGEVGDVITIQVH 21156
Score = 32.0 bits (71), Expect = 8.9
Identities = 45/189 (23%), Positives = 76/189 (40%), Gaps = 25/189 (13%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW---LRIKSMEP 547
V +G P L ++ + W DG L SK+ I + L+I S E
Sbjct: 4590 VTQGDPATLQVKFSGTKEITAKW-FKDGQELTL-----GSKYKISVTDTVSILKIISTEK 4643
Query: 548 SDSGLYQCIAQVRDEMDRMVYRV------LVQSPSTQPAEKDTVTIGKNPGESVTLPCNA 601
DSG Y +V++++ R + L+ PS K +I G + L C
Sbjct: 4644 KDSGEYTF--EVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSI---KGSFIDLECIV 4698
Query: 602 LAIPEAHLSWILPNRRIINDLANTSHVYMLPNGT--LSIPKVQVSDSGYYRCVAVNQQGA 659
+ W ++ I A+ + + + T L I +++ +DSG Y C A N+ G
Sbjct: 4699 AGSHPISIQWFKDDQEIS---ASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGH 4755
Query: 660 DHFTVGITV 668
+ + +TV
Sbjct: 4756 NQCSGHLTV 4764
Score = 32.0 bits (71), Expect = 8.9
Identities = 22/86 (25%), Positives = 35/86 (40%), Gaps = 2/86 (2%)
Query: 2054 LENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLA 2113
L +++ G I + T P P + W D + + N V T+ I +
Sbjct: 13697 LAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIEN--VPKKSTVTIVDSK 13754
Query: 2114 PKDSGRYECVAANLVGSARRTVQLNV 2139
D+G Y A N+ G A V++NV
Sbjct: 13755 RSDTGTYIIEAVNVCGRATAVVEVNV 13780
Score = 32.0 bits (71), Expect = 8.9
Identities = 27/100 (27%), Positives = 45/100 (45%), Gaps = 7/100 (7%)
Query: 2045 LPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFL----HGN-L 2099
+PP I + E + + G +++I K P P++ W + + + H N L
Sbjct: 16116 MPPSIDLK--EFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKL 16173
Query: 2100 FVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
V TL I D+G Y A N +G+A + ++LNV
Sbjct: 16174 VVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 16213
Score = 32.0 bits (71), Expect = 8.9
Identities = 21/84 (25%), Positives = 33/84 (39%), Gaps = 1/84 (1%)
Query: 2550 EKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSV 2609
E + AG T+ G P P+ W +G+++++ + +L I
Sbjct: 17518 EGLVVKAGTTVRFPAIIRGVPVPTAKWTT-DGSEIKTDEHYTVETDNFSSVLTIKNCLRR 17576
Query: 2610 DAGAYRCVARNAAGHTERLVSLKV 2633
D G Y+ NAAG V L V
Sbjct: 17577 DTGEYQITVSNAAGSKTVAVHLTV 17600
Score = 32.0 bits (71), Expect = 8.9
Identities = 22/74 (29%), Positives = 30/74 (40%), Gaps = 2/74 (2%)
Query: 1862 TVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQ 1921
T +V A D G+P P VTW K + T TR+ N L I+ +
Sbjct: 22156 TFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQT--TRVNAESTENNSLLTIKDACRE 22213
Query: 1922 DRGQYMCTASNLHG 1935
D G Y+ +N G
Sbjct: 22214 DVGHYVVKLTNSAG 22227
Score = 32.0 bits (71), Expect = 8.9
Identities = 27/124 (21%), Positives = 52/124 (41%), Gaps = 9/124 (7%)
Query: 2023 YKCVASNAAGADS-----LAIRLHVAALPPVIHQEKLEN--ISLPPGLSIHIHCTAKAAP 2075
++ A N AG L + + PP I + + + + G ++ + P
Sbjct: 26445 FRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKP 26504
Query: 2076 LPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTV 2135
LP V + DG ++ + + + N T+ ++ D+GRYE AAN G+ + +
Sbjct: 26505 LPKVT-LSRDGVPLKATMRFNTEITA-ENLTINLKESVTADAGRYEITAANSSGTTKAFI 26562
Query: 2136 QLNV 2139
+ V
Sbjct: 26563 NIVV 26566
Score = 32.0 bits (71), Expect = 8.9
Identities = 33/149 (22%), Positives = 56/149 (37%), Gaps = 14/149 (9%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG---WLRIK 543
+D T G QLSC + P I W ++++ K+ + S G L +
Sbjct: 30540 KDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQS------RKYKMSSDGRTHTLTVM 30593
Query: 544 SMEPSDSGLYQCIAQVR-DEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNAL 602
+ E D G+Y CIA E++ +L +P P G ++ L +
Sbjct: 30594 TEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYI 30653
Query: 603 AIPEAHLSWILPNRRIIND----LANTSH 627
P ++W + + N + NT H
Sbjct: 30654 GRPVPAMTWFHGQKLLQNSENITIENTEH 30682
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 208 bits (529), Expect = 7e-53
Identities = 264/1063 (24%), Positives = 401/1063 (37%), Gaps = 170/1063 (15%)
Query: 1826 SGSFHQSSSKFFAGGPPASKFWSLGEK---PQILTKSPQTVSVTAETDTVFPCEATGKPK 1882
+G + + + G P L E P ++ P V C+ +G P
Sbjct: 1646 TGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPP 1705
Query: 1883 PFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH--GLDRMV 1940
+ W++ + P+ QR + L VQ D G Y+CT NLH R
Sbjct: 1706 HYFYWSREDGRPV--PSGTQQRHQ---GSELHFPSVQPSDAGVYICTCRNLHQSNTSRAE 1760
Query: 1941 VLLSVTVQQP-QILASHYQDVTVYLGDTIAMECLAKG-TPAPQISWIFPDRRVWQTVSPV 1998
+L++ +P + + +V G + C AK +PA + W R+ P
Sbjct: 1761 LLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVW----TRLHNGKLPT 1816
Query: 1999 EGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAA----LPPV--IHQE 2052
+ N L+I+ SD G Y C SN D LHV A PV IH
Sbjct: 1817 R---AMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPP 1873
Query: 2053 KLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNL 2112
+L ++ PG C+A +P P++ W G G Q+ +HG G L + +
Sbjct: 1874 QL---TVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHG-------GILRLPAV 1923
Query: 2113 APKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASG 2172
P D +Y C A + G L+V R+ SP RT V G T++L C A+G
Sbjct: 1924 EPTDQAQYLCRAHSSAGQQVARAVLHV-HGGGGPRVQ-VSPERTQVHAGRTVRLYCRAAG 1981
Query: 2173 DPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYV 2232
P I WR + S + I TL++ ++T DAG YLCVA + G
Sbjct: 1982 VPSATITWRKEGGSLPPQARSERTDI-----ATLLIPAITTADAGFYLCVATSPAGTAQA 2036
Query: 2233 VLKV------DVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVN 2286
++V D P KI E + V G L ++CV G + +++W GSL
Sbjct: 2037 RIQVVVLSASDASPPPVKI---ESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL-- 2091
Query: 2287 SFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVV---- 2342
+ + L +V + G+Y C EN G E + V V+
Sbjct: 2092 ------------PPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTH 2139
Query: 2343 -----------TAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTS 2391
T P I + V G + + C G+ +VTW +K +
Sbjct: 2140 SGPSYTPVPGSTRPIRIEPS---SSHVAEGQTLDLNCVVPGQAHAQVTW----HKRGGSL 2192
Query: 2392 SEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAG--EDRKTVWIHVNVQPPKINGNPNP 2448
++Q + G+LL + + +DSG Y C V ++G E V I +V P I P
Sbjct: 2193 PARHQTH--GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPI--PPVR 2248
Query: 2449 ITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSL 2508
I + A G + C G +V W + G LPA R V G+ L I
Sbjct: 2249 IESSSSTVAEGQTLDLSCVVAGQAHAQVTW-YKRGGSLPA-----RHQVRGS-RLYIFQA 2301
Query: 2509 RKSDSVQLVCMARNEGGEARLILQLTVLEPME--------KPIFHDPISEKITAMAGHTI 2560
+D+ Q VC A N G EA + + +T + +PI +P S ++ G T+
Sbjct: 2302 SPADAGQYVCRASN-GMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVA--EGQTL 2358
Query: 2561 SLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARN 2620
LNC G + W + G L + +L + S D+G Y C
Sbjct: 2359 DLNCVVPGQSHAQVTW-------HKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLG 2411
Query: 2621 AAGHTERLVSLKV---------GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSW 2671
++ E V + + G+ P + + + G+TL L C G + +W
Sbjct: 2412 SSVPLEASVLVTIEPAGSVPALGVTPTVRIE-SSSSQVAEGQTLDLNCLVAGQAHAQVTW 2470
Query: 2672 TLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIV--- 2728
H G R + L + + + D G YVCR+ G S+ V +
Sbjct: 2471 ------HKRGGSLPAR-HQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQR 2523
Query: 2729 --------IAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITW-----ELPDKSHL 2775
+AYP RI S + G+T+ LNC+ ITW LP +
Sbjct: 2524 LSGSHSQGVAYPVRIESSSASL---ANGHTLDLNCLVASQAPHTITWYKRGGSLPSRH-- 2578
Query: 2776 KAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
++ G+R PQ T D+G Y C N GS
Sbjct: 2579 ------QIVGSRLRIPQ-------VTPADSGEYVCHVSNGAGS 2608
Score = 186 bits (471), Expect = 4e-46
Identities = 237/1025 (23%), Positives = 378/1025 (36%), Gaps = 155/1025 (15%)
Query: 1852 KPQILTKSPQ-TVSVTAETDTVFPCEATGK-PKPFVTWTKVSTGALMTPNTRIQRFEVLK 1909
KP +T Q + SV D F C A K P + WT++ G L T R F
Sbjct: 1769 KPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPT---RAMDF---- 1821
Query: 1910 NGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSV----TVQQPQILASHYQDVTVYLG 1965
NG L IR VQ+ D G Y+CT SN+ +D+ L V T+ P +++ H +TV G
Sbjct: 1822 NGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAP-VVSIHPPQLTVQPG 1880
Query: 1966 DTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKC 2025
C A G+P P + W + + G I L + +D+ Y C
Sbjct: 1881 QLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGI-------LRLPAVEPTDQAQYLC 1933
Query: 2026 VASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD 2085
A ++AG LHV Q E + G ++ ++C A P ++ W
Sbjct: 1934 RAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEG 1993
Query: 2086 GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA-- 2143
G+ ++ ++ TL I + D+G Y CVA + G+A+ +Q+ V A+
Sbjct: 1994 GSLPPQARSERTDI-----ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDA 2048
Query: 2144 --ANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVF 2201
+I +SP T+ G TL L+C +G ++ W + SR++
Sbjct: 2049 SPPPVKIESSSPSVTE---GQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLR-- 2103
Query: 2202 ANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVV---------------MKPAKIE 2246
+ V+ D+G+Y+C N G + V V+ +P +IE
Sbjct: 2104 ------LPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIE 2157
Query: 2247 HKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN 2306
+ V G L ++CV G + +++W GSL +
Sbjct: 2158 PSSSH---VAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQT--------------HG 2200
Query: 2307 GTLYFNEVGMREEGDYTCFAENQVGKDEMRVRV----KVVTAPATIRNKTYLAVQVPYGD 2362
L ++V + G+Y C G E V V V+ P + V G
Sbjct: 2201 SLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQ 2260
Query: 2363 VVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRN 2422
+ ++C G+ +VTW + ++Q+ + L I +A +D+G Y C N
Sbjct: 2261 TLDLSCVVAGQAHAQVTWYKRGGSL----PARHQV-RGSRLYIFQASPADAGQYVCRASN 2315
Query: 2423 SAGEDRKTVWI----HVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLW 2478
E TV + N+ P + P I A G ++C G +V W
Sbjct: 2316 GM-EASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTW 2374
Query: 2479 AFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEP 2538
G LP R HG+ L + +DS + VC + +T+
Sbjct: 2375 -HKRGGSLPV-----RHQTHGS-LLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPA 2427
Query: 2539 MEKPIFHDPISEKITAMA-----GHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRF 2593
P + +I + + G T+ LNC AG + W + G L
Sbjct: 2428 GSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTW-------HKRGGSLPAR 2480
Query: 2594 YHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQY---------H 2644
+ L + ++ D+G Y C ++G E V + + + +
Sbjct: 2481 HQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIES 2540
Query: 2645 NLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVF 2704
+ S+ NG TL L C +W G Q +G L + + +
Sbjct: 2541 SSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVG-------SRLRIPQVTPA 2593
Query: 2705 DRGTYVCRMETEYGPSVTSIPVIV----------IAYPPRITSEPTPVIYTRPGNTVKLN 2754
D G YVC + G TS+ V + ++ P RI S V+ G T+ LN
Sbjct: 2594 DSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVV---EGQTLDLN 2650
Query: 2755 CMAMGIPKADITW-----ELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYK 2809
C+ P+A ITW LP + H G RL+ + D+G Y
Sbjct: 2651 CVVARQPQAIITWYKRGGSLPSR-HQTHGSHLRLH--------------QMSVADSGEYV 2695
Query: 2810 CMAKN 2814
C A N
Sbjct: 2696 CRANN 2700
Score = 181 bits (459), Expect = 9e-45
Identities = 241/992 (24%), Positives = 382/992 (38%), Gaps = 129/992 (13%)
Query: 1764 VIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSV 1823
V+PG + H+ T+H G + P H QT GS L ++ S S ++ +
Sbjct: 2749 VVPG---QAHAQVTWHKRGG--SLPSHH--QTRGS-RLRLHHV----SPADSGEYVCRVM 2796
Query: 1824 QSSGSFHQSSSKFF-AGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPK 1882
SSG S A G A + G P I + P + V C G+
Sbjct: 2797 GSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIE-PSSSRVAEGQTLDLKCVVPGQAH 2855
Query: 1883 PFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVL 1942
VTW K G + ++ L + +V D G+Y C + G VL
Sbjct: 2856 AQVTWHK--RGGNLPARHQVH------GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVL 2907
Query: 1943 LSVTVQQPQILASHYQDVTVYL---------GDTIAMECLAKGTPAPQISWIFPDRRVWQ 1993
+++ P + + +Y+ G T+ + C+ G Q++W ++
Sbjct: 2908 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTW-------YK 2960
Query: 1994 TVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPV---IH 2050
+ R H ++ L + S +D G Y C A++ G + A +PP +
Sbjct: 2961 RGGSLPARHQTHGSQ-LRLHLVSPADSGEYVCRAASGPGPEQEAS--FTVTVPPSEGSSY 3017
Query: 2051 QEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI------RPSQFLHGNLFVFPN 2104
+ + IS+ P S T + S + ++ DG +Q L N+ + PN
Sbjct: 3018 RLRSPVISIDPPSS-----TVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPN 3072
Query: 2105 GTLY-IRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGT 2163
G++ I P + G Y CVA+N G A+ V L+V + P V+ G
Sbjct: 3073 GSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVH-GPPTVSVLPEGP--VWVKVGKA 3129
Query: 2164 LKLDCSASGDP-----WPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGD 2218
+ L+C ++G+P W RI P+K DS + L + S DAG
Sbjct: 3130 VTLECVSAGEPRSSARWTRIS-STPAKLEQRTYGLMDS------HAVLQISSAKPSDAGT 3182
Query: 2219 YLCVARNKVGDDYVVLKVDV---VMKPAKIE-HKEENDHKVFYGGDLKVDCVATGLPNPE 2274
Y+C+A+N +G ++V V M P + EE + V G + C ATG P P
Sbjct: 3183 YVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPT 3242
Query: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
I WS L D TL V ++ G Y C A + G E
Sbjct: 3243 IHWSKLRSPLPWQHRLEGD--------------TLIIPRVAQQDSGQYICNATSPAGHAE 3288
Query: 2335 MRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEK 2394
+ + V + P + +VQ G+ V + C A G P W + + ++ +
Sbjct: 3289 ATIILHVESPPYATTVPEHASVQA--GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATAR 3346
Query: 2395 YQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNP------ 2448
++ L ++A DSG Y C V N G + V P + P
Sbjct: 3347 NEL-----LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPT 3401
Query: 2449 --ITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIR 2506
+T E + G+ C ++ W F EG LP G+ + +G L I+
Sbjct: 3402 VQVTPQLETKSIGASVEFHCAVPSDRGTQLRW-FKEGGQLPP---GHSVQ---DGVLRIQ 3454
Query: 2507 SLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSA 2566
+L +S +C A G+A+ QL V++ + + + S + T + GH + C A
Sbjct: 3455 NLDQSCQGTYICQAHGPWGKAQASAQL-VIQALPSVLINIRTSVQ-TVVVGHAVEFECLA 3512
Query: 2567 AGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTE 2626
G P P + W + G L+ ++ G++ I+ + DAG YRC A NAAG T+
Sbjct: 3513 LGDPKPQVTWS-------KVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQ 3565
Query: 2627 RLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLG 2686
V L V P+ + V + G PC G SW+ +G +L
Sbjct: 3566 SHVLLLVQALPQISMPQE--VRVPAGSAAVFPCIASGYPTPDISWSKLDG-------SLP 3616
Query: 2687 RVSLLDNGTLTVREASVFDRGTYVCRMETEYG 2718
S L+N L + D GTYVC G
Sbjct: 3617 PDSRLENNMLMLPSVRPQDAGTYVCTATNRQG 3648
Score = 178 bits (451), Expect = 8e-44
Identities = 192/789 (24%), Positives = 302/789 (38%), Gaps = 106/789 (13%)
Query: 1875 CEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH 1934
C G+ VTW K T L + V D G+Y+C A++
Sbjct: 2946 CVVPGQAHAQVTWYKRGGSLPARHQTH--------GSQLRLHLVSPADSGEYVCRAASGP 2997
Query: 1935 GLDRMVVLLSVTVQQPQILASHYQ-----------DVTVYLGDTIAMECLAKGTPAP-QI 1982
G ++ S TV P S Y+ TV G + +CL AP +
Sbjct: 2998 GPEQEA---SFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISL 3054
Query: 1983 SWIFPDRRVWQTV--SPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL 2040
W ++ + V SP IT+ R S+ G Y+CVASNA G + L
Sbjct: 3055 EWKTRNQELEDNVHISPNGSIITIVGTRP--------SNHGTYRCVASNAYGVAQSVVNL 3106
Query: 2041 HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF 2100
V PP + + + G ++ + C + P S RW T + Q +G
Sbjct: 3107 SVHG-PPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYG--L 3163
Query: 2101 VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAA--NARITGTSPRRTDV 2158
+ + L I + P D+G Y C+A N +G+A++ V++ V A A V
Sbjct: 3164 MDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTV 3223
Query: 2159 RYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGD 2218
G T L CSA+G P P I W + + + R++ TL++ V +D+G
Sbjct: 3224 EAGHTATLRCSATGSPAPTIHWS-----KLRSPLPWQHRLE---GDTLIIPRVAQQDSGQ 3275
Query: 2219 YLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWS 2278
Y+C A + G + + V P E V G +++ C+A G P WS
Sbjct: 3276 YICNATSPAGHAEATIILHVESPPYATTVPEHAS--VQAGETVQLQCLAHGTPPLTFQWS 3333
Query: 2279 LPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVR 2338
SL G T R N L+F + G Y C N+VG E +
Sbjct: 3334 RVGSSL---------PGRATAR-----NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQ 3379
Query: 2339 VKVVTAPATIRNKTYLAVQVP------------YGDVVTVACEAKGEPMPKVTWLSPTNK 2386
+ V P ++ + A P G V C + ++ W +
Sbjct: 3380 LLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQ 3439
Query: 2387 VIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNP 2446
+ P S QDG L IQ +S G Y C G+ + + + + P +
Sbjct: 3440 LPPGHS-----VQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLI--- 3491
Query: 2447 NPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIR 2506
N T+V+ + G + + +C A G P P+V W+ G + P V G + I
Sbjct: 3492 NIRTSVQTVVVGHAVEF-ECLALGDPKPQVTWSKVGGHLRPG-------IVQSGGVVRIA 3543
Query: 2507 SLRKSDSVQLVCMARNEGG--EARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNC 2564
+ +D+ Q C A N G ++ ++L + L + P +++ AG C
Sbjct: 3544 HVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMP-------QEVRVPAGSAAVFPC 3596
Query: 2565 SAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGH 2624
A+G PTP + W +G+ L +L+ + ML + + DAG Y C A N G
Sbjct: 3597 IASGYPTPDISWSKLDGS-LPPDSRLE------NNMLMLPSVRPQDAGTYVCTATNRQGK 3649
Query: 2625 TERLVSLKV 2633
+ L+V
Sbjct: 3650 VKAFAHLQV 3658
Score = 177 bits (449), Expect = 1e-43
Identities = 238/1036 (22%), Positives = 382/1036 (36%), Gaps = 171/1036 (16%)
Query: 1859 SPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKV 1918
SP+ V A C A G P +TW K G + P R +R ++ TL+I +
Sbjct: 1961 SPERTQVHAGRTVRLYCRAAGVPSATITWRK--EGGSLPPQARSERTDI---ATLLIPAI 2015
Query: 1919 QVQDRGQYMCTASNLHGLDR---MVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAK 1975
D G Y+C A++ G + VV+LS + P + +V G T+ + C+
Sbjct: 2016 TTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVA 2075
Query: 1976 GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS 2035
G+ Q++W ++ + +H +R L + + S +D G Y C N +G
Sbjct: 2076 GSAHAQVTW-------YRRGGSLPPHTQVHGSR-LRLPQVSPADSGEYVCRVENGSGPKE 2127
Query: 2036 LAIRLHV----------AALPPVIHQEKLENIS--LPPGLSIHIHCTAKAAPLPSVRWVL 2083
+I + V +P ++E S + G ++ ++C V W
Sbjct: 2128 ASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHK 2187
Query: 2084 GDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
G+ Q HG+L L + + P DSG Y C G +V + ++ +
Sbjct: 2188 RGGSLPARHQ-THGSL-------LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASV 2239
Query: 2144 ANARITGT--SPRRTDVRYGGTLKLDCSASGDPWPRILW-----RLPSKRMIDALFSFDS 2196
I + V G TL L C +G ++ W LP++ + S
Sbjct: 2240 IPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRG-----S 2294
Query: 2197 RIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVV----------MKPAKIE 2246
R+ +F + DAG Y+C A N + V +P +IE
Sbjct: 2295 RLYIF--------QASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIE 2346
Query: 2247 HKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN 2306
+ +V G L ++CV G + +++W GSL ++ G + Y
Sbjct: 2347 ---PSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLP---VRHQTHGSLLRLY----- 2395
Query: 2307 GTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTA---PA-----TIRNKTYLAVQV 2358
+ + G+Y C E V V + A PA T+R ++ + QV
Sbjct: 2396 ------QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSS-QV 2448
Query: 2359 PYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTC 2418
G + + C G+ +VTW +K + ++Q++ L+Q +DSG Y C
Sbjct: 2449 AEGQTLDLNCLVAGQAHAQVTW----HKRGGSLPARHQVHGSRLRLLQVTP-ADSGEYVC 2503
Query: 2419 LVRNSAGEDRKTVWIHVNVQPPKINGN-------PNPITTVREIAAGGSRKLIDCKAEGI 2471
V S+G +V + + +++G+ P I + A G ++C
Sbjct: 2504 RVVGSSGTQEASVLVTIQ---QRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQ 2560
Query: 2472 PTPRVLWAFPEGVVLPAPYY--GNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG--EA 2527
+ W + G LP+ + G+R L I + +DS + VC N G E
Sbjct: 2561 APHTITW-YKRGGSLPSRHQIVGSR--------LRIPQVTPADSGEYVCHVSNGAGSRET 2611
Query: 2528 RLILQLTVLEPMEKPIFHDPI---SEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
LI+ + P PI S T + G T+ LNC A P + W G+ L
Sbjct: 2612 SLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGS-L 2670
Query: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQY- 2643
S Q + L + +S D+G Y C A N E S+ + + P A
Sbjct: 2671 PSRHQTHGSH------LRLHQMSVADSGEYVCRANNNIDALE--ASIVISVSPSAGSPSA 2722
Query: 2644 ----------HNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN 2693
+ + GETL L C PG + +W G QT G
Sbjct: 2723 PGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRG------- 2775
Query: 2694 GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEP----TPVIYTRP-- 2747
L + S D G YVCR+ GP S+ V + A P P I P
Sbjct: 2776 SRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSS 2835
Query: 2748 -----GNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQ 2802
G T+ L C+ G A +TW H + G L +H L + +
Sbjct: 2836 SRVAEGQTLDLKCVVPGQAHAQVTW------HKRGG---NLPARHQVHGP-LLRLNQVSP 2885
Query: 2803 RDAGFYKCMAKNILGS 2818
D+G Y C G+
Sbjct: 2886 ADSGEYSCQVTGSSGT 2901
Score = 159 bits (403), Expect = 3e-38
Identities = 149/597 (24%), Positives = 232/597 (38%), Gaps = 88/597 (14%)
Query: 1860 PQTVSVTAETDT--------VFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVL--K 1909
P TVSV E C + G+P+ WT++S+ TP QR L
Sbjct: 3111 PPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISS----TPAKLEQRTYGLMDS 3166
Query: 1910 NGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQ-----PQILASHYQDVTVYL 1964
+ L I + D G Y+C A N G + V + V PQ+ A ++TV
Sbjct: 3167 HAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE-AELTVEA 3225
Query: 1965 GDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYK 2024
G T + C A G+PAP I W + SP+ + L E TL I + D G Y
Sbjct: 3226 GHTATLRCSATGSPAPTIHWS-------KLRSPLPWQHRL-EGDTLIIPRVAQQDSGQYI 3277
Query: 2025 CVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLG 2084
C A++ AG I LHV + P E+ S+ G ++ + C A P + +W
Sbjct: 3278 CNATSPAGHAEATIILHVESPPYATTVP--EHASVQAGETVQLQCLAHGTPPLTFQWS-- 3333
Query: 2085 DGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAA 2144
R L G N L+ AP+DSGRY C N VGSA QL VQ
Sbjct: 3334 -----RVGSSLPGRATA-RNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPG 3387
Query: 2145 NARITG----------TSPRRTDVRYGGTLKLDCSASGDPWPRILW-----RLPSKRMID 2189
+ T +P+ G +++ C+ D ++ W +LP +
Sbjct: 3388 SLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ 3447
Query: 2190 ALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKE 2249
+G L ++++ G Y+C A G ++ + P+ + +
Sbjct: 3448 -------------DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIR 3494
Query: 2250 ENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTL 2309
+ V G ++ +C+A G P P+++WS GG + +V + G +
Sbjct: 3495 TSVQTVVVGHAVEFECLALGDPKPQVTWS--------------KVGGHLRPGIVQSGGVV 3540
Query: 2310 YFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACE 2369
V + + G Y C A N G + V + V P + V+VP G C
Sbjct: 3541 RIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQ---EVRVPAGSAAVFPCI 3597
Query: 2370 AKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGE 2426
A G P P ++W + P S ++ L++ + D+G Y C N G+
Sbjct: 3598 ASGYPTPDISWSKLDGSLPPDSR-----LENNMLMLPSVRPQDAGTYVCTATNRQGK 3649
Score = 155 bits (392), Expect = 5e-37
Identities = 228/1015 (22%), Positives = 360/1015 (35%), Gaps = 143/1015 (14%)
Query: 1864 SVTAETDTV-FPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQD 1922
S AE +T+ C G+ VTW K TR R L + V D
Sbjct: 2736 SHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSR--------LRLHHVSPAD 2787
Query: 1923 RGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHY-------------QDVTVYLGDTIA 1969
G+Y+C G VL VT++ A H V G T+
Sbjct: 2788 SGEYVCRVMGSSGPLEASVL--VTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLD 2845
Query: 1970 MECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASN 2029
++C+ G Q++W + + R +H L + + S +D G Y C +
Sbjct: 2846 LKCVVPGQAHAQVTW-------HKRGGNLPARHQVH-GPLLRLNQVSPADSGEYSCQVTG 2897
Query: 2030 AAGA--DSLAIRLHVAALPPVIHQEKLENISLPP-------GLSIHIHCTAKAAPLPSVR 2080
++G S+ + + ++ P+ + I + G ++ ++C V
Sbjct: 2898 SSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVT 2957
Query: 2081 WVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVG---SARRTVQL 2137
W G+ Q HG+ L + ++P DSG Y C AA+ G A TV +
Sbjct: 2958 WYKRGGSLPARHQ-THGS-------QLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV 3009
Query: 2138 NVQRAAA---NARITGTSPRRTDVRYGGTLKLDCSASGDPWPRIL-WRLPSKRMIDALFS 2193
++ + + P + V+ G C P L W+ ++ + D
Sbjct: 3010 PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELED---- 3065
Query: 2194 FDSRIKVFANGTLV-VKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEEND 2252
+ + NG+++ + + G Y CVA N G V+ + V P + E
Sbjct: 3066 ---NVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV-HGPPTVSVLPEGP 3121
Query: 2253 HKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY-VVFNNGTLYF 2311
V G + ++CV+ G P W+ + S + + Y ++ ++ L
Sbjct: 3122 VWVKVGKAVTLECVSAGEPRSSARWTR---------ISSTPAKLEQRTYGLMDSHAVLQI 3172
Query: 2312 NEVGMREEGDYTCFAENQVGKDEMRVRVKVVT------APATIRNKTYLAVQVPYGDVVT 2365
+ + G Y C A+N +G + +V V V T AP + L V+ G T
Sbjct: 3173 SSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEA--GHTAT 3230
Query: 2366 VACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAG 2425
+ C A G P P + W S +P + TL+I + + DSG Y C + AG
Sbjct: 3231 LRCSATGSPAPTIHW-SKLRSPLPWQHR----LEGDTLIIPRVAQQDSGQYICNATSPAG 3285
Query: 2426 EDRKTVWIHVNVQPPKINGNPNPITTVREIAA--GGSRKLIDCKAEGIPTPRVLWAFPEG 2483
T+ +HV +P TTV E A+ G + C A G P W+ G
Sbjct: 3286 HAEATIILHVE--------SPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWS-RVG 3336
Query: 2484 VVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEK-P 2542
LP R T N L DS + C N+ G A QL V P P
Sbjct: 3337 SSLPG-----RATAR-NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLP 3390
Query: 2543 IFHDPISEKITAMA---------GHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRF 2593
P T G ++ +C+ L W + G QL
Sbjct: 3391 ATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRW-------FKEGGQLPPG 3443
Query: 2594 YHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLV-SIING 2652
+ DG+L I L G Y C A G + L + P V +++ G
Sbjct: 3444 HSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVG 3503
Query: 2653 ETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCR 2712
++ C G + + +W+ G G G G + + + D G Y C
Sbjct: 3504 HAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSG-------GVVRIAHVELADAGQYRCT 3556
Query: 2713 METEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDK 2772
G + + + ++V A P S P V G+ C+A G P DI+W D
Sbjct: 3557 ATNAAGTTQSHVLLLVQALPQ--ISMPQEV-RVPAGSAAVFPCIASGYPTPDISWSKLDG 3613
Query: 2773 SHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
S +RL N + P +DAG Y C A N G ++ V
Sbjct: 3614 S---LPPDSRLENNMLMLPS-------VRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
Score = 135 bits (341), Expect = 4e-31
Identities = 219/1055 (20%), Positives = 373/1055 (35%), Gaps = 204/1055 (19%)
Query: 1864 SVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDR 1923
SVT C G VTW + G + P+T++ L + +V D
Sbjct: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYR--RGGSLPPHTQVH------GSRLRLPQVSPADS 2112
Query: 1924 GQYMCTASNLHGLDRMVVLLSV---TVQQPQIL--------------ASHYQDVTVYLGD 1966
G+Y+C N G + +SV T P +SH + G
Sbjct: 2113 GEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAE-----GQ 2167
Query: 1967 TIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCV 2026
T+ + C+ G Q++W + + R H + L + + + +D G Y C
Sbjct: 2168 TLDLNCVVPGQAHAQVTW-------HKRGGSLPARHQTHGS-LLRLHQVTPADSGEYVCH 2219
Query: 2027 ASNAAGA--DSLAIRLHVAALPPVIHQEKLENIS--LPPGLSIHIHCTAKAAPLPSVRWV 2082
+G S+ + + + +P I ++E+ S + G ++ + C V W
Sbjct: 2220 VVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWY 2279
Query: 2083 LGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAAN-----LVGSARRTVQL 2137
G+ Q L++F +P D+G+Y C A+N + + T
Sbjct: 2280 KRGGSLPARHQVRGSRLYIF--------QASPADAGQYVCRASNGMEASITVTVTGTQGA 2331
Query: 2138 NVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSR 2197
N+ A + + P + V G TL L+C G ++ W + + S
Sbjct: 2332 NLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSL 2391
Query: 2198 IKVFANGTLVVKSVTDKDAGDYLC-VARNKVGDDYVVLKVDVVMKPA---------KIEH 2247
++++ + D+G+Y+C V + V + VL V ++PA
Sbjct: 2392 LRLY--------QASPADSGEYVCRVLGSSVPLEASVL---VTIEPAGSVPALGVTPTVR 2440
Query: 2248 KEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG 2307
E + +V G L ++C+ G + +++W GSL R+ V +
Sbjct: 2441 IESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL-------------PARHQV-HGS 2486
Query: 2308 TLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKV-----------VTAPATIRNKTYLAV 2356
L +V + G+Y C G E V V + V P I + +
Sbjct: 2487 RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSS---A 2543
Query: 2357 QVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNY 2416
+ G + + C + +TW + ++QI L I + +DSG Y
Sbjct: 2544 SLANGHTLDLNCLVASQAPHTITWYKRGGSL----PSRHQIV-GSRLRIPQVTPADSGEY 2598
Query: 2417 TCLVRNSAGEDRKTVWI--------HVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKA 2468
C V N AG ++ + HV P I + T V G ++C
Sbjct: 2599 VCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVE-----GQTLDLNCVV 2653
Query: 2469 EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARN--EGGE 2526
P + W + G LP+ R HG+ L + + +DS + VC A N + E
Sbjct: 2654 ARQPQAIITW-YKRGGSLPS-----RHQTHGS-HLRLHQMSVADSGEYVCRANNNIDALE 2706
Query: 2527 ARLILQLTVLEPMEK-PIFHDPI---SEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGT 2582
A +++ ++ P PI S G T+ LNC G + W
Sbjct: 2707 ASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWH----- 2761
Query: 2583 DLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQ 2642
+ G L + L + +S D+G Y C ++G E S+ V ++ +
Sbjct: 2762 --KRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLE--ASVLVTIEASGSSA 2817
Query: 2643 YH--------------NLVSIINGETLKLPCTPPGAGQGRFSW-----TLPNGMHLEGPQ 2683
H + + G+TL L C PG + +W LP + GP
Sbjct: 2818 VHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGP- 2876
Query: 2684 TLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEP---T 2740
L + + S D G Y C++ G S+ V + P P
Sbjct: 2877 -----------LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQ 2925
Query: 2741 PVI------YTRPGNTVKLNCMAMGIPKADITW-----ELPDKSHLKAGVQARLYGNRFL 2789
P+ + G T+ LNC+ G A +TW LP + H G Q RL+
Sbjct: 2926 PIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR-HQTHGSQLRLH----- 2979
Query: 2790 HPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTY 2824
+ D+G Y C A + G + + ++
Sbjct: 2980 ---------LVSPADSGEYVCRAASGPGPEQEASF 3005
Score = 114 bits (284), Expect = 2e-24
Identities = 128/486 (26%), Positives = 186/486 (38%), Gaps = 57/486 (11%)
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYT 2417
VP G ++ C+ G P W + +P+ ++ Q +Q L Q SD+G Y
Sbjct: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQ--QRHQGSELHFPSVQPSDAGVYI 1745
Query: 2418 CLVRNSAGEDRKTVWIHVNVQPPKINGNPNPIT-TVREIAAGGSRKLID----CKAEG-I 2471
C RN + + V P K PIT TV E + R D C A+
Sbjct: 1746 CTCRNLHQSNTSRAELLVTEAPSK------PITVTVEEQRSQSVRPGADVTFICTAKSKS 1799
Query: 2472 PTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARN----EGGEA 2527
P ++W LP + NG L IR+++ SD+ VC N + G A
Sbjct: 1800 PAYTLVWTRLHNGKLPTR------AMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTA 1853
Query: 2528 RLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSG 2587
L +Q + H P ++T G CSA G+PTP+L W G L +
Sbjct: 1854 TLHVQASGTLSAPVVSIHPP---QLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAK 1910
Query: 2588 QQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV--GLKPEANKQYHN 2645
Q+ G+L + + D Y C A ++AG L V G P
Sbjct: 1911 AQIH------GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPER 1964
Query: 2646 LVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFD 2705
+ G T++L C G +W G PQ R D TL + + D
Sbjct: 1965 -TQVHAGRTVRLYCRAAGVPSATITWRKEGGS--LPPQ--ARSERTDIATLLIPAITTAD 2019
Query: 2706 RGTYVCRMETEYGPSVTSIPVIVI----AYPPRITSEPTPVIYTRPGNTVKLNCMAMGIP 2761
G Y+C + G + I V+V+ A PP + E + T G T+ LNC+ G
Sbjct: 2020 AGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTE-GQTLDLNCVVAGSA 2078
Query: 2762 KADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSK 2821
A +TW S +++G+R PQ + D+G Y C +N GS K
Sbjct: 2079 HAQVTWYRRGGS---LPPHTQVHGSRLRLPQ-------VSPADSGEYVCRVEN--GSGPK 2126
Query: 2822 TTYIHV 2827
I V
Sbjct: 2127 EASITV 2132
Score = 97.8 bits (242), Expect = 1e-19
Identities = 83/325 (25%), Positives = 133/325 (40%), Gaps = 37/325 (11%)
Query: 1819 ITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQI-LTKSPQTVSVTAETDTVFPCEA 1877
+T+ V S+ +F Q + G PA+ G P + +T +T S+ A + F C
Sbjct: 3367 VTNKVGSAEAFAQLLVQGPPGSLPATSI-PAGSTPTVQVTPQLETKSIGASVE--FHCAV 3423
Query: 1878 TGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLD 1937
+ W K G + P +Q +G L I+ + +G Y+C A G
Sbjct: 3424 PSDRGTQLRWFK--EGGQLPPGHSVQ------DGVLRIQNLDQSCQGTYICQAHGPWGKA 3475
Query: 1938 RMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSP 1997
+ L + ++ TV +G + ECLA G P PQ++W S
Sbjct: 3476 QASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTW-----------SK 3524
Query: 1998 VEGRIT---LHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKL 2054
V G + + + I +D G Y+C A+NAAG + L V ALP + ++
Sbjct: 3525 VGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQE- 3583
Query: 2055 ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAP 2114
+ +P G + C A P P + W DG+ + P L N+ + P+ + P
Sbjct: 3584 --VRVPAGSAAVFPCIASGYPTPDISWSKLDGS-LPPDSRLENNMLMLPS-------VRP 3633
Query: 2115 KDSGRYECVAANLVGSARRTVQLNV 2139
+D+G Y C A N G + L V
Sbjct: 3634 QDAGTYVCTATNRQGKVKAFAHLQV 3658
Score = 58.2 bits (139), Expect = 1e-07
Identities = 47/192 (24%), Positives = 76/192 (39%), Gaps = 22/192 (11%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
TV G + C+ S +P++ W G L A + G LR+ ++EP+D
Sbjct: 1876 TVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQ--------IHGGILRLPAVEPTD 1927
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQ-----SPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
Y C A + V R ++ P Q + + T + G +V L C A +
Sbjct: 1928 QAQYLCRAH--SSAGQQVARAVLHVHGGGGPRVQVSPERTQV---HAGRTVRLYCRAAGV 1982
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
P A ++W R+ L + TL IP + +D+G+Y CVA + G +
Sbjct: 1983 PSATITW----RKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARI 2038
Query: 665 GITVTKKGSGLP 676
+ V P
Sbjct: 2039 QVVVLSASDASP 2050
Score = 56.2 bits (134), Expect = 4e-07
Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 22/190 (11%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
V +GG L C V S +W DG + P L S++PSD+
Sbjct: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPV------PSGTQQRHQGSELHFPSVQPSDA 1741
Query: 551 GLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKN------PGESVTLPCNALAI 604
G+Y C + + + +LV ++P TVT+ + PG VT C A +
Sbjct: 1742 GVYICTCRNLHQSNTSRAELLVTEAPSKPI---TVTVEEQRSQSVRPGADVTFICTAKSK 1798
Query: 605 PEAH-LSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFT 663
A+ L W R+ N T + NG L+I VQ+SD+G Y C N D T
Sbjct: 1799 SPAYTLVWT----RLHNGKLPTRAMDF--NGILTIRNVQLSDAGTYVCTGSNMFAMDQGT 1852
Query: 664 VGITVTKKGS 673
+ V G+
Sbjct: 1853 ATLHVQASGT 1862
Score = 53.1 bits (126), Expect = 4e-06
Identities = 45/171 (26%), Positives = 68/171 (39%), Gaps = 21/171 (12%)
Query: 489 QTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPS 548
QTV+ G + C P + W G + + S G +RI +E +
Sbjct: 3498 QTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG---------IVQSGGVVRIAHVELA 3548
Query: 549 DSGLYQCIAQVRDEMDRMVYRVLVQS-PSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
D+G Y+C A + +LVQ+ P ++ V G + PC A P
Sbjct: 3549 DAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGS----AAVFPCIASGYPTP 3604
Query: 608 HLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+SW ++ L S L N L +P V+ D+G Y C A N+QG
Sbjct: 3605 DISW----SKLDGSLPPDSR---LENNMLMLPSVRPQDAGTYVCTATNRQG 3648
Score = 48.9 bits (115), Expect = 7e-05
Identities = 39/131 (29%), Positives = 60/131 (45%), Gaps = 15/131 (11%)
Query: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQP------AEKDTVTIGKNPGE 593
L+I S +PSD+G Y C+AQ + V+V + + P AE+ +T+ G
Sbjct: 3170 LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTV--EAGH 3227
Query: 594 SVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
+ TL C+A P + W ++ + L + L TL IP+V DSG Y C A
Sbjct: 3228 TATLRCSATGSPAPTIHW----SKLRSPL---PWQHRLEGDTLIIPRVAQQDSGQYICNA 3280
Query: 654 VNQQGADHFTV 664
+ G T+
Sbjct: 3281 TSPAGHAEATI 3291
Score = 48.1 bits (113), Expect = 1e-04
Identities = 25/84 (29%), Positives = 43/84 (51%), Gaps = 2/84 (2%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
PQ++T +++ + F C A G P P + W +++ G + + + R+ GT
Sbjct: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINW-RLNWGHIPS-HPRVTVTSEGGRGT 463
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGL 1936
L+IR V+ D+G Y C A N G+
Sbjct: 464 LIIRDVKESDQGAYTCEAMNARGM 487
Score = 47.0 bits (110), Expect = 3e-04
Identities = 28/86 (32%), Positives = 41/86 (47%), Gaps = 8/86 (9%)
Query: 1950 PQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHE--- 2006
PQ++ + + G T+ C+A G P P I+W R W + P R+T+
Sbjct: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINW----RLNWGHI-PSHPRVTVTSEGG 460
Query: 2007 NRTLSIKEASFSDRGVYKCVASNAAG 2032
TL I++ SD+G Y C A NA G
Sbjct: 461 RGTLIIRDVKESDQGAYTCEAMNARG 486
Score = 46.6 bits (109), Expect = 3e-04
Identities = 59/242 (24%), Positives = 85/242 (35%), Gaps = 36/242 (14%)
Query: 2608 SVDAGAYRCVARNAAGHTERLV-----------SLKVG-LKPEANK-----QYHNLVSII 2650
S+ AG YRC A G+T + S++ G PE N+ + H SI+
Sbjct: 1630 SLGAGGYRCTACEP-GYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIV 1688
Query: 2651 -NGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTY 2709
G + L C G+ F W+ +G P G L D G Y
Sbjct: 1689 PQGGSHSLRCQVSGSPPHYFYWSREDGR----PVPSGTQQRHQGSELHFPSVQPSDAGVY 1744
Query: 2710 VCRMETEYGPSVTSIPVIVIAYPPR---ITSEPTPVIYTRPGNTVKLNCMAMG-IPKADI 2765
+C + + + ++V P + +T E RPG V C A P +
Sbjct: 1745 ICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTL 1804
Query: 2766 TWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYI 2825
W L R + G LTI++ DAG Y C N+ D T +
Sbjct: 1805 VWTRLHNGKLPT---------RAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATL 1855
Query: 2826 HV 2827
HV
Sbjct: 1856 HV 1857
Score = 45.8 bits (107), Expect = 6e-04
Identities = 48/185 (25%), Positives = 74/185 (40%), Gaps = 34/185 (18%)
Query: 486 QRDQTVLEGGPCQLSCNVKASESPS--IFWV-LPDGSILKAPMDDPDSKFSILSSGWLRI 542
QR Q+V G C K S+SP+ + W L +G + MD +G L I
Sbjct: 1778 QRSQSVRPGADVTFICTAK-SKSPAYTLVWTRLHNGKLPTRAMD---------FNGILTI 1827
Query: 543 KSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTV---TIGKNPGESVTLPC 599
++++ SD+G Y C MD+ + VQ+ T A ++ + PG+ C
Sbjct: 1828 RNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRC 1887
Query: 600 NALAIPEAHLSWI------LPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
+A P L W LP + I+ G L +P V+ +D Y C A
Sbjct: 1888 SATGSPTPTLEWTGGPGGQLPAKAQIH------------GGILRLPAVEPTDQAQYLCRA 1935
Query: 654 VNQQG 658
+ G
Sbjct: 1936 HSSAG 1940
Score = 45.4 bits (106), Expect = 8e-04
Identities = 28/77 (36%), Positives = 35/77 (45%), Gaps = 1/77 (1%)
Query: 2547 PISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGL 2606
P E I A G T++ C A G PTP + W L N + S ++ G L I +
Sbjct: 411 PPRESIQASRGQTVTFTCVAIGVPTPIINWRL-NWGHIPSHPRVTVTSEGGRGTLIIRDV 469
Query: 2607 SSVDAGAYRCVARNAAG 2623
D GAY C A NA G
Sbjct: 470 KESDQGAYTCEAMNARG 486
Score = 45.1 bits (105), Expect = 0.001
Identities = 62/245 (25%), Positives = 99/245 (40%), Gaps = 38/245 (15%)
Query: 450 KVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESP 509
+V+ S TQ + + T R + S + P ++ G L+C V +
Sbjct: 2504 RVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPH 2563
Query: 510 SIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYR 569
+I W GS+ S+ I+ S LRI + P+DSG Y C
Sbjct: 2564 TITWYKRGGSL--------PSRHQIVGSR-LRIPQVTPADSGEYVCHVSNGAGSRETSLI 2614
Query: 570 VLVQS------PSTQP---AEKDTVTIGKNPGESVTLPCNALAIPEAHLSWI-----LPN 615
V +Q PS P E + T+ + G+++ L C P+A ++W LP+
Sbjct: 2615 VTIQGSGSSHVPSVSPPIRIESSSPTVVE--GQTLDLNCVVARQPQAIITWYKRGGSLPS 2672
Query: 616 RRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGL 675
R + SH L + ++ V+DSG Y C A N A ++ I+V+ +G
Sbjct: 2673 RH----QTHGSH--------LRLHQMSVADSGEYVCRANNNIDALEASIVISVS-PSAGS 2719
Query: 676 PSKRG 680
PS G
Sbjct: 2720 PSAPG 2724
Score = 44.3 bits (103), Expect = 0.002
Identities = 29/89 (32%), Positives = 40/89 (44%), Gaps = 10/89 (11%)
Query: 2732 PPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWEL---PDKSHLKAGVQARLYGNRF 2788
PP++ + P I G TV C+A+G+P I W L SH + V + G R
Sbjct: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSE--GGR- 461
Query: 2789 LHPQGSLTIQHATQRDAGFYKCMAKNILG 2817
G+L I+ + D G Y C A N G
Sbjct: 462 ----GTLIIRDVKESDQGAYTCEAMNARG 486
Score = 42.7 bits (99), Expect = 0.005
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 9/76 (11%)
Query: 2355 AVQVPYGDVVTVACEAKGEPMPKVTWLS-----PTNKVIPTSSEKYQIYQDGTLLIQKAQ 2409
++Q G VT C A G P P + W P++ + +SE + GTL+I+ +
Sbjct: 415 SIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR----GTLIIRDVK 470
Query: 2410 RSDSGNYTCLVRNSAG 2425
SD G YTC N+ G
Sbjct: 471 ESDQGAYTCEAMNARG 486
Score = 42.7 bits (99), Expect = 0.005
Identities = 48/194 (24%), Positives = 71/194 (36%), Gaps = 18/194 (9%)
Query: 484 AVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIK 543
A + + TV G L C+ S +P+I W S L++P+ L L I
Sbjct: 3216 AEEAELTVEAGHTATLRCSATGSPAPTIHW-----SKLRSPLPWQHR----LEGDTLIIP 3266
Query: 544 SMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALA 603
+ DSG Y C A + V+SP + ++ GE+V L C A
Sbjct: 3267 RVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASV--QAGETVQLQCLAHG 3324
Query: 604 IPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFT 663
P W R+ + L + N L + DSG YRC N+ G+
Sbjct: 3325 TPPLTFQW----SRVGSSLPGRATAR---NELLHFERAAPEDSGRYRCRVTNKVGSAEAF 3377
Query: 664 VGITVTKKGSGLPS 677
+ V LP+
Sbjct: 3378 AQLLVQGPPGSLPA 3391
Score = 41.6 bits (96), Expect = 0.011
Identities = 43/192 (22%), Positives = 77/192 (40%), Gaps = 17/192 (8%)
Query: 481 PSGAVQRDQTVLEGG-PCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW 539
P V ++T + G +L C S +I W GS+ P ++
Sbjct: 1956 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSL------PPQARSERTDIAT 2009
Query: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQ---PAEKDTVTIGKNPGESVT 596
L I ++ +D+G Y C+A + +V+V S S P + ++ + G+++
Sbjct: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLD 2069
Query: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
L C A ++W R L + V+ L +P+V +DSG Y C N
Sbjct: 2070 LNCVVAGSAHAQVTWY----RRGGSLPPHTQVH---GSRLRLPQVSPADSGEYVCRVENG 2122
Query: 657 QGADHFTVGITV 668
G ++ ++V
Sbjct: 2123 SGPKEASITVSV 2134
Score = 41.6 bits (96), Expect = 0.011
Identities = 52/214 (24%), Positives = 78/214 (36%), Gaps = 38/214 (17%)
Query: 477 VMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILS 536
+ IEPS + V EG L+C V + W GS+ P+
Sbjct: 2343 IRIEPSSS-----QVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL---PVRHQTH------ 2388
Query: 537 SGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTI-----GKNP 591
LR+ P+DSG Y C V ++ + PA T T+
Sbjct: 2389 GSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQV 2448
Query: 592 GESVTLPCNALAIPEAH--LSW-----ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVS 644
E TL N L +AH ++W LP R ++ L + +V +
Sbjct: 2449 AEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH------------GSRLRLLQVTPA 2496
Query: 645 DSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSK 678
DSG Y C V G +V +T+ ++ SG S+
Sbjct: 2497 DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQ 2530
Score = 40.8 bits (94), Expect = 0.019
Identities = 49/213 (23%), Positives = 84/213 (39%), Gaps = 18/213 (8%)
Query: 459 YSQTISTKDTRQARGRSWVM-IEPSGAVQRDQTVLEGGPCQLSCNVKASESP-SIFWVLP 516
++ T+ + R RS V+ I+P + TV +G C + +P S+ W
Sbjct: 3005 FTVTVPPSEGSSYRLRSPVISIDPPSS-----TVQQGQDASFKCLIHDGAAPISLEW--- 3056
Query: 517 DGSILKAPMDDPDSKFSILSSGWL-RIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSP 575
K + + I +G + I PS+ G Y+C+A + + V + V P
Sbjct: 3057 -----KTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
Query: 576 STQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGT 635
T + + G++VTL C + P + W + L ++ M +
Sbjct: 3112 PTVSVLPEG-PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAK-LEQRTYGLMDSHAV 3169
Query: 636 LSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
L I + SD+G Y C+A N G V + V
Sbjct: 3170 LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIV 3202
Score = 39.7 bits (91), Expect = 0.043
Identities = 29/85 (34%), Positives = 39/85 (45%), Gaps = 9/85 (10%)
Query: 2446 PNPITTVREI--AAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVH---GN 2500
P +T RE A+ G C A G+PTP + W G + P R+TV G
Sbjct: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHP----RVTVTSEGGR 461
Query: 2501 GSLDIRSLRKSDSVQLVCMARNEGG 2525
G+L IR +++SD C A N G
Sbjct: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
Score = 39.3 bits (90), Expect = 0.056
Identities = 48/202 (23%), Positives = 71/202 (35%), Gaps = 53/202 (26%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
V EG L+C V + W GS L A S+ LR+ + P+DS
Sbjct: 2936 VTEGQTLDLNCVVPGQAHAQVTWYKRGGS-LPARHQTHGSQ--------LRLHLVSPADS 2986
Query: 551 GLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAH-- 608
G Y C A P + TVT+ + G S L ++I
Sbjct: 2987 GEYVCRA--------------ASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSST 3032
Query: 609 ---------------------LSWILPNRRIINDLANTSHVYMLPNGTL-SIPKVQVSDS 646
L W N+ + +V++ PNG++ +I + S+
Sbjct: 3033 VQQGQDASFKCLIHDGAAPISLEWKTRNQEL------EDNVHISPNGSIITIVGTRPSNH 3086
Query: 647 GYYRCVAVNQQGADHFTVGITV 668
G YRCVA N G V ++V
Sbjct: 3087 GTYRCVASNAYGVAQSVVNLSV 3108
Score = 39.3 bits (90), Expect = 0.056
Identities = 34/165 (20%), Positives = 62/165 (37%), Gaps = 16/165 (9%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLY 553
G + C V + + W G + + G LRI++++ S G Y
Sbjct: 3414 GASVEFHCAVPSDRGTQLRWFKEGGQLPPGHS---------VQDGVLRIQNLDQSCQGTY 3464
Query: 554 QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWIL 613
C A + ++++Q+ + T G +V C AL P+ ++W
Sbjct: 3465 ICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK 3524
Query: 614 PNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ + + G + I V+++D+G YRC A N G
Sbjct: 3525 VGGHLRPGIVQS-------GGVVRIAHVELADAGQYRCTATNAAG 3562
Score = 38.9 bits (89), Expect = 0.073
Identities = 50/207 (24%), Positives = 80/207 (38%), Gaps = 31/207 (14%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
TV+EG L+C V I W GS+ S+ S LR+ M +D
Sbjct: 2640 TVVEGQTLDLNCVVARQPQAIITWYKRGGSL--------PSRHQTHGSH-LRLHQMSVAD 2690
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQ------SPS----TQPAEKDTVTIGKNPGESVTLPC 599
SG Y C A + +D + +++ SPS + P ++ + GE++ L C
Sbjct: 2691 SGEYVCRAN--NNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNC 2748
Query: 600 NALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
A ++W + SH + L + V +DSG Y C + G
Sbjct: 2749 VVPGQAHAQVTWHKRGGSL------PSH-HQTRGSRLRLHHVSPADSGEYVCRVMGSSGP 2801
Query: 660 DHFTVGITVTKKGSG---LPSKRGRRP 683
+V +T+ GS +P+ G P
Sbjct: 2802 LEASVLVTIEASGSSAVHVPAPGGAPP 2828
Score = 38.1 bits (87), Expect = 0.12
Identities = 26/88 (29%), Positives = 36/88 (40%), Gaps = 8/88 (9%)
Query: 2045 LPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDG---TQIRPSQFLHGNLFV 2101
+PP + E+I G ++ C A P P + W L G + R + G
Sbjct: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG--- 460
Query: 2102 FPNGTLYIRNLAPKDSGRYECVAANLVG 2129
GTL IR++ D G Y C A N G
Sbjct: 461 --RGTLIIRDVKESDQGAYTCEAMNARG 486
Score = 38.1 bits (87), Expect = 0.12
Identities = 48/222 (21%), Positives = 79/222 (35%), Gaps = 46/222 (20%)
Query: 477 VMIEPSGAV------------QRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAP 524
V IEP+G+V V EG L+C V + W GS+
Sbjct: 2422 VTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL---- 2477
Query: 525 MDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPST------- 577
++ + S LR+ + P+DSG Y C V +Q +
Sbjct: 2478 ----PARHQVHGSR-LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGV 2532
Query: 578 -QPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWI-----LPNRRIINDLANTSHVYML 631
P ++ + G ++ L C + ++W LP+R + +
Sbjct: 2533 AYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSR------------HQI 2580
Query: 632 PNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGS 673
L IP+V +DSG Y C N G+ ++ +T+ GS
Sbjct: 2581 VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGS 2622
Score = 37.4 bits (85), Expect = 0.21
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 19/82 (23%)
Query: 586 TIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPN---------GTL 636
+I + G++VT C A+ +P ++W L N H+ P GTL
Sbjct: 415 SIQASRGQTVTFTCVAIGVPTPIINWRL----------NWGHIPSHPRVTVTSEGGRGTL 464
Query: 637 SIPKVQVSDSGYYRCVAVNQQG 658
I V+ SD G Y C A+N +G
Sbjct: 465 IIRDVKESDQGAYTCEAMNARG 486
Score = 36.6 bits (83), Expect = 0.36
Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 8/74 (10%)
Query: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
G + CVA G+P P I+W L G + + + S G GTL +V
Sbjct: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEG--------GRGTLIIRDVKES 472
Query: 2318 EEGDYTCFAENQVG 2331
++G YTC A N G
Sbjct: 473 DQGAYTCEAMNARG 486
Score = 36.2 bits (82), Expect = 0.47
Identities = 27/82 (32%), Positives = 36/82 (43%), Gaps = 9/82 (10%)
Query: 2151 TSPRRT-DVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANG---TL 2206
T PR + G T+ C A G P P I WRL + R+ V + G TL
Sbjct: 410 TPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPS-----HPRVTVTSEGGRGTL 464
Query: 2207 VVKSVTDKDAGDYLCVARNKVG 2228
+++ V + D G Y C A N G
Sbjct: 465 IIRDVKESDQGAYTCEAMNARG 486
Score = 35.0 bits (79), Expect = 1.1
Identities = 26/93 (27%), Positives = 38/93 (40%), Gaps = 9/93 (9%)
Query: 468 TRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDD 527
T Q+ V P ++ ++ V G C +P I W DGS+
Sbjct: 3563 TTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSL------P 3616
Query: 528 PDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVR 560
PDS+ L + L + S+ P D+G Y C A R
Sbjct: 3617 PDSR---LENNMLMLPSVRPQDAGTYVCTATNR 3646
Score = 34.7 bits (78), Expect = 1.4
Identities = 54/223 (24%), Positives = 76/223 (34%), Gaps = 45/223 (20%)
Query: 477 VMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILS 536
+ IEPS + V EG L C V + W G++ +
Sbjct: 2829 IRIEPSSS-----RVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQ---------VH 2874
Query: 537 SGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLV----QSPS-------TQPAEKDTV 585
LR+ + P+DSG Y C QV + VLV SP QP +
Sbjct: 2875 GPLLRLNQVSPADSGEYSC--QVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEAS 2932
Query: 586 TIGKNPGESVTLPCNALAIPEAHLSWI-----LPNRRIINDLANTSHVYMLPNGTLSIPK 640
+ G+++ L C A ++W LP R + L +
Sbjct: 2933 SSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR------------HQTHGSQLRLHL 2980
Query: 641 VQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRP 683
V +DSG Y C A + G + TVT S S R R P
Sbjct: 2981 VSPADSGEYVCRAASGPGPEQ-EASFTVTVPPSEGSSYRLRSP 3022
Score = 32.3 bits (72), Expect = 6.8
Identities = 47/205 (22%), Positives = 74/205 (36%), Gaps = 40/205 (19%)
Query: 477 VMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILS 536
+ IEPS + V EG L+C V + W GS+
Sbjct: 2154 IRIEPSSS-----HVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTH--------- 2199
Query: 537 SGWLRIKSMEPSDSGLYQC-IAQVRDEMDRMVYRVLVQSPSTQP-----AEKDTVTIGKN 590
LR+ + P+DSG Y C + ++ V + S P E + T+ +
Sbjct: 2200 GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAE- 2258
Query: 591 PGESVTLPCNALAIPEAHLSWI-----LPNRRIINDLANTSHVYMLPNGTLSIPKVQVSD 645
G+++ L C A ++W LP R + + L I + +D
Sbjct: 2259 -GQTLDLSCVVAGQAHAQVTWYKRGGSLPAR------------HQVRGSRLYIFQASPAD 2305
Query: 646 SGYYRCVAVNQQGADHFTVGITVTK 670
+G Y C A N A TV +T T+
Sbjct: 2306 AGQYVCRASNGMEAS-ITVTVTGTQ 2329
Score = 32.3 bits (72), Expect = 6.8
Identities = 46/207 (22%), Positives = 70/207 (33%), Gaps = 33/207 (15%)
Query: 479 IEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG 538
I P TV EG LSC V + W GS+ ++ + S
Sbjct: 2244 IPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSL--------PARHQVRGSR 2295
Query: 539 WLRIKSMEPSDSGLYQCIAQVRDEMDRMV-------YRVLVQSPSTQPAEKDTVTIGKNP 591
L I P+D+G Y C A E V + + STQP + +
Sbjct: 2296 -LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAE 2354
Query: 592 GESVTLPCNALAIPEAHLSW-----ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDS 646
G+++ L C A ++W LP R + L + + +DS
Sbjct: 2355 GQTLDLNCVVPGQSHAQVTWHKRGGSLPVR------------HQTHGSLLRLYQASPADS 2402
Query: 647 GYYRCVAVNQQGADHFTVGITVTKKGS 673
G Y C + +V +T+ GS
Sbjct: 2403 GEYVCRVLGSSVPLEASVLVTIEPAGS 2429
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 177 bits (448), Expect = 2e-43
Identities = 201/715 (28%), Positives = 291/715 (40%), Gaps = 115/715 (16%)
Query: 1874 PCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNL 1933
PC A+G P P + W K G + ++R + + L I ++ +D G Y+C +N
Sbjct: 306 PCTASGYPIPAIRWLK--DGRPLPADSRWTK----RITGLTISDLRTEDSGTYICEVTNT 359
Query: 1934 HGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQ 1993
G +L V P + + + +G T+ + C G+P I W R +
Sbjct: 360 FGSAEATGILMVI--DPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWY----RNTE 413
Query: 1994 TVSPVEG-RITLHENRTLSIKEASFSDRGVYKCVASNAAG-ADSLAIRLHVAALPPVIHQ 2051
V P E I N TL I A S G Y+C A+ A A AI P ++
Sbjct: 414 LVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSS 473
Query: 2052 --EKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGT--- 2106
EK+ N PG + C AK AP P+V W L D +R N + +GT
Sbjct: 474 FSEKVVN----PGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH-RTNQYTMSDGTTIS 528
Query: 2107 -LYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQ-----RAAANARITGTSPRRTDVRY 2160
+ + +D G Y C A NLVGSA ++NV+ RA N IT + R T
Sbjct: 529 HMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN--ITAVAGRDT---- 582
Query: 2161 GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDS-RIKVFANGTLVVKSVTD-KDAGD 2218
++C G P+ I W DAL D+ R VF NGTL + V D G+
Sbjct: 583 ----LINCRVIGYPYYSIKWYK------DALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
Query: 2219 YLCVA----RNKVGDD-YVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNP 2273
YLC + + +V +KV +++P + G L + CV + P
Sbjct: 633 YLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPAS-------IGQLLYIPCVVSSGDMP 685
Query: 2274 -EISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGK 2332
I+W DG ++ S G T F + +L + V ++ G+YTC A N
Sbjct: 686 IRITWR-KDGQVIIS------GSGVTIESKEFMS-SLQISSVSLKHNGNYTCIASN---- 733
Query: 2333 DEMRVRVKVVTAPATIRNKTYLAVQVP-------------YGDVVTVACEAKGEPMPKVT 2379
A AT+ + L V+VP YG + C G P PKV
Sbjct: 734 -----------AAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVM 782
Query: 2380 WLSPTNKVIPTS------SEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGED-RKTVW 2432
W P + + QI + +LLI+ D G Y C N G D K+++
Sbjct: 783 WKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMF 842
Query: 2433 IHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYG 2492
+ V + P I +PN TT IA G K ++C A G + W + V+ P
Sbjct: 843 LTVKI-PAMITSHPN--TT---IAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMR 896
Query: 2493 NRITVHGNG-----SLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKP 2542
I NG +L ++ + DSV C A N GE R ++QLTV EP + P
Sbjct: 897 YAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP 951
Score = 162 bits (409), Expect = 6e-39
Identities = 220/898 (24%), Positives = 343/898 (38%), Gaps = 90/898 (10%)
Query: 1958 QDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEAS- 2016
Q VT + + C A G+P+ + W + V +H N TL + S
Sbjct: 93 QQVTFSSSVGVVVPCPAAGSPSAALRWYLA---TGDDIYDVPHIRHVHANGTLQLYPFSP 149
Query: 2017 -----FSDRGVYKCVASNAAGA-DSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCT 2070
F Y C A NAAG S IR+ P + ++E+ G C
Sbjct: 150 SAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREP--YTVRVEDQRSMRGNVAVFKCL 207
Query: 2071 AKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDS-GRYECVAANLVG 2129
++ V V + + S F+ +G LYI ++ +D+ Y C+ +
Sbjct: 208 IPSSVQEYVSVVSWEKDTV--SIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYS 265
Query: 2130 SARRT---VQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKR 2186
R +L+V A + +V G T++L C+ASG P P I W L R
Sbjct: 266 GETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRW-LKDGR 324
Query: 2187 MIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDD------YVVLKVDVVM 2240
+ A DSR G L + + +D+G Y+C N G V+ + V +
Sbjct: 325 PLPA----DSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTL 379
Query: 2241 KPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKR 2300
P K+ K G + + C TG P I W N+ + D +
Sbjct: 380 TPKKL--------KTGIGSTVILSCALTGSPEFTIRWYR------NTELVLPDEAISIRG 425
Query: 2301 YVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPY 2360
+N TL G Y CFA + + + + I + V P
Sbjct: 426 ---LSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNP- 481
Query: 2361 GDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIY--QDGTLL----IQKAQRSDSG 2414
G+ ++ C AKG P P VTW ++ S + Y DGT + + Q D G
Sbjct: 482 GEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGG 541
Query: 2415 NYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTP 2474
Y C RN G I+V PP I N IT V G LI+C+ G P
Sbjct: 542 VYRCTARNLVGSAEYQARINVR-GPPSIRAMRN-ITAV-----AGRDTLINCRVIGYPYY 594
Query: 2475 RVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKS-DSVQLVCMARNEGGEARLILQL 2533
+ W + + ++LP +R V NG+L + ++K D + +C + +L +
Sbjct: 595 SIKW-YKDALLLPD---NHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQ---PQLSISQ 647
Query: 2534 TVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRF 2593
+V ++ P P E A G + + C + P + +G + SG +
Sbjct: 648 SVHVAVKVPPLIQPF-EFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIE 706
Query: 2594 YHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGE 2653
+ L IS +S G Y C+A NAA R L V + P Q +N I G+
Sbjct: 707 SKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIY-GK 765
Query: 2654 TLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTL------GRVSLLDNGTLTVREASVFDRG 2707
L C+ G + W G PQ GR+ +L N +L +R D G
Sbjct: 766 AGVLNCSVDGYPPPKVMWKHAKGSG--NPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIG 823
Query: 2708 TYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITW 2767
Y+C+ G ++ + + P ITS P I + G+ +LNC A G I W
Sbjct: 824 YYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK-GHAKELNCTARGERPIIIRW 882
Query: 2768 EL------PDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSD 2819
E PD+ ++ + + G+ + +L ++ A + D+ F+ C A N G D
Sbjct: 883 EKGDTVIDPDRV-MRYAIATKDNGDEVV---STLKLKPADRGDSVFFSCHAINSYGED 936
Score = 159 bits (401), Expect = 5e-38
Identities = 222/923 (24%), Positives = 365/923 (39%), Gaps = 122/923 (13%)
Query: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVL 1908
+G + S Q V+ ++ V PC A G P + W ++TG + I+ V
Sbjct: 81 VGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRW-YLATGDDIYDVPHIR--HVH 137
Query: 1909 KNGTLVIRKVQ-------VQDRGQYMCTASNLHGLDRMV-VLLSVTVQQPQILASHYQDV 1960
NGTL + + D Y CTA N G R + + ++P + +D
Sbjct: 138 ANGTLQLYPFSPSAFNSFIHD-NDYFCTAENAAGKIRSPNIRVKAVFREPYTV--RVEDQ 194
Query: 1961 TVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPV-EGRITLHENRTLSIKEASFSD 2019
G+ +CL + +S + ++ TVS + E R + + L I + D
Sbjct: 195 RSMRGNVAVFKCLIPSSVQEYVSVVSWEK---DTVSIIPEHRFFITYHGGLYISDVQKED 251
Query: 2020 R-GVYKCVASNAAGADS-------LAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTA 2071
Y+C+ + ++ L++ ++P ++ + + + G ++ + CTA
Sbjct: 252 ALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTIL--DGFHSQEVWAGHTVELPCTA 309
Query: 2072 KAAPLPSVRWVLGDGTQI----RPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANL 2127
P+P++RW L DG + R ++ + G L I +L +DSG Y C N
Sbjct: 310 SGYPIPAIRW-LKDGRPLPADSRWTKRITG---------LTISDLRTEDSGTYICEVTNT 359
Query: 2128 VGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRM 2187
GSA T L V + +P++ G T+ L C+ +G P I W ++ +
Sbjct: 360 FGSAEATGILMV----IDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELV 415
Query: 2188 I-DALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNK--VGDDYVVLKVDVVMKPAK 2244
+ D S I+ +N TL++ S +G Y C A K D+ ++ ++
Sbjct: 416 LPDEAIS----IRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIV 471
Query: 2245 IEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVF 2304
E+ V G + C A G P P ++W+L D +V D RT +Y +
Sbjct: 472 SSFSEK---VVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVR------DGSHRTNQYTMS 522
Query: 2305 NNGTL-YFNEVG--MREEGDYTCFAENQVGKDEMRVRVKVVTAPA--TIRNKTYLAVQVP 2359
+ T+ + N G +R+ G Y C A N VG E + R+ V P+ +RN T +A
Sbjct: 523 DGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVA---- 578
Query: 2360 YGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRS-DSGNYTC 2418
G + C G P + W + ++ + + ++++GTL + Q+ D G Y C
Sbjct: 579 -GRDTLINCRVIGYPYYSIKWYK--DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC 635
Query: 2419 --LVRNSAGEDRKTVWIHVNVQ-PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTP- 2474
L++ + +HV V+ PP I P ++ G I C P
Sbjct: 636 SVLIQPQLSISQS---VHVAVKVPPLIQPFEFPPASI------GQLLYIPCVVSSGDMPI 686
Query: 2475 RVLWAFPEGVVLPAPYYGNRITVHGN---GSLDIRSLRKSDSVQLVCMARNEGGEARLIL 2531
R+ W V++ G+ +T+ SL I S+ + C+A N
Sbjct: 687 RITWRKDGQVIIS----GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRER 742
Query: 2532 QLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQ 2591
QL V P + + + I AG LNCS G P P ++W G SG Q
Sbjct: 743 QLIVRVP-PRFVVQPNNQDGIYGKAG---VLNCSVDGYPPPKVMWKHAKG----SGNPQQ 794
Query: 2592 RFYHKADGMLHISGLSSV--------DAGAYRCVARNAAGHTERLVSLKVGLK-PEANKQ 2642
G + I SS+ D G Y C A N G T+ S+ + +K P
Sbjct: 795 YHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVG-TDISKSMFLTVKIPAMITS 853
Query: 2643 YHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGR--VSLLDNG-----T 2695
+ N I G +L CT G W G + P + R ++ DNG T
Sbjct: 854 HPNTTIAIKGHAKELNCTARGERPIIIRW--EKGDTVIDPDRVMRYAIATKDNGDEVVST 911
Query: 2696 LTVREASVFDRGTYVCRMETEYG 2718
L ++ A D + C YG
Sbjct: 912 LKLKPADRGDSVFFSCHAINSYG 934
Score = 146 bits (369), Expect = 2e-34
Identities = 155/622 (24%), Positives = 249/622 (40%), Gaps = 52/622 (8%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P +T +P+ + + + C TG P+ + W + + L+ P+ I L N T
Sbjct: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTE--LVLPDEAIS-IRGLSNET 430
Query: 1913 LVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMEC 1972
L+I Q G Y C A+ + ++++ P+I++S + + V G+ ++ C
Sbjct: 431 LLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSS-FSEKVVNPGEQFSLMC 489
Query: 1973 LAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLS---IKEASFSDRGVYKCVASN 2029
AKG P P ++W D + + S + T+ + T+S + D GVY+C A N
Sbjct: 490 AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARN 549
Query: 2030 AAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI 2089
G+ R++V P + + NI+ G I+C P S++W
Sbjct: 550 LVGSAEYQARINVRGPPSI---RAMRNITAVAGRDTLINCRVIGYPYYSIKW-------Y 599
Query: 2090 RPSQFLHGN--LFVFPNGTLYIRNLAP-KDSGRYEC---VAANLVGSARRTVQLNVQRAA 2143
+ + L N VF NGTL + ++ D G Y C + L S V + V
Sbjct: 600 KDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLI 659
Query: 2144 ANARITGTSPRRTDVRYGGTLKLDC-SASGDPWPRILWRLPSKRMIDALFSFDSRIKVFA 2202
S G L + C +SGD RI WR + +I K F
Sbjct: 660 QPFEFPPAS-------IGQLLYIPCVVSSGDMPIRITWRKDGQVIISG-SGVTIESKEFM 711
Query: 2203 NGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLK 2262
+ +L + SV+ K G+Y C+A N ++ V + P + + N+ YG
Sbjct: 712 S-SLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFV--VQPNNQDGIYGKAGV 768
Query: 2263 VDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDY 2322
++C G P P++ W GS Q T R + N +L V + G Y
Sbjct: 769 LNCSVDGYPPPKVMWKHAKGS---GNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYY 825
Query: 2323 TCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLS 2382
C A N VG D + V PA I + + + G + C A+GE + W
Sbjct: 826 LCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK-GHAKELNCTARGERPIIIRWEK 884
Query: 2383 PTNKVIPTSSEKYQIYQD-------GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHV 2435
+ P +Y I TL ++ A R DS ++C NS GEDR + + V
Sbjct: 885 GDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTV 944
Query: 2436 NVQPPKINGNPNPITTVREIAA 2457
+PP P +RE+ A
Sbjct: 945 Q-EPP-----DPPELEIREVKA 960
Score = 139 bits (349), Expect = 5e-32
Identities = 188/814 (23%), Positives = 314/814 (38%), Gaps = 96/814 (11%)
Query: 2052 EKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRN 2111
+ L+ ++ + + + C A +P ++RW L G I + V NGTL +
Sbjct: 90 DSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIR---HVHANGTLQLYP 146
Query: 2112 LAPK------DSGRYECVAANLVGSARR-TVQLN-VQRAAANARITGTSPRRTDVRYGGT 2163
+P Y C A N G R +++ V R R+ R +V
Sbjct: 147 FSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNV---AV 203
Query: 2164 LKLDCSASGDPWPRIL-WRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDA-GDYLC 2221
K +S + ++ W + +I + R + +G L + V +DA Y C
Sbjct: 204 FKCLIPSSVQEYVSVVSWEKDTVSIIP-----EHRFFITYHGGLYISDVQKEDALSTYRC 258
Query: 2222 VARNKVGDDYVV---LKVDVVMKPAKIEHKEENDH--KVFYGGDLKVDCVATGLPNPEIS 2276
+ ++K + ++ V I + H +V+ G +++ C A+G P P I
Sbjct: 259 ITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIR 318
Query: 2277 WSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMR 2336
W L DG + + TKR L +++ + G Y C N G E
Sbjct: 319 W-LKDGRPLPA------DSRWTKRIT-----GLTISDLRTEDSGTYICEVTNTFGSAEA- 365
Query: 2337 VRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQ 2396
+ +V P + T ++ G V ++C G P + W T V+P + +
Sbjct: 366 TGILMVIDPLHV-TLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIR 424
Query: 2397 IYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVRE-I 2455
+ TLLI AQ+S SG Y C A + I + +G P +++ E +
Sbjct: 425 GLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALE------DGTPRIVSSFSEKV 478
Query: 2456 AAGGSRKLIDCKAEGIPTPRVLWAF-PEGVVLPAPYYGNRITVHGN---GSLDIRSLRKS 2511
G + + C A+G P P V WA E +V + N+ T+ +++ +
Sbjct: 479 VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIR 538
Query: 2512 DSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPT 2571
D C ARN G A ++ V P + ITA+AG +NC G P
Sbjct: 539 DGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRN-----ITAVAGRDTLINCRVIGYPY 593
Query: 2572 PSLVW-----VLPNGTDLQSGQQLQRFYHKADGMLHISGL-SSVDAGAYRC-VARNAAGH 2624
S+ W +LP+ R +G L ++ + +D G Y C V
Sbjct: 594 YSIKWYKDALLLPDN---------HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLS 644
Query: 2625 TERLVSLKVGLKPEANKQYHNLVSIINGETLKLPC-TPPGAGQGRFSWTLPNGMHLEGP- 2682
+ V + V + P SI G+ L +PC G R +W + + G
Sbjct: 645 ISQSVHVAVKVPPLIQPFEFPPASI--GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSG 702
Query: 2683 QTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPT-- 2740
T+ + +L + S+ G Y C + + +V+ +++ PPR +P
Sbjct: 703 VTIESKEFM--SSLQISSVSLKHNGNYTC-IASNAAATVSRERQLIVRVPPRFVVQPNNQ 759
Query: 2741 PVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLY------GNRFLHPQGS 2794
IY + G LNC G P + W+ H K + Y G + P S
Sbjct: 760 DGIYGKAG---VLNCSVDGYPPPKVMWK-----HAKGSGNPQQYHPVPLTGRIQILPNSS 811
Query: 2795 LTIQHATQRDAGFYKCMAKNILGSD-SKTTYIHV 2827
L I+H + D G+Y C A N +G+D SK+ ++ V
Sbjct: 812 LLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTV 845
Score = 102 bits (253), Expect = 7e-21
Identities = 219/1034 (21%), Positives = 379/1034 (36%), Gaps = 181/1034 (17%)
Query: 1797 GSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQIL 1856
GS TN M T S +T G ++ +++ G ++ P I
Sbjct: 512 GSHRTN--QYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI- 568
Query: 1857 TKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIR 1916
++ + ++ A DT+ C G P + W K AL+ P+ Q V +NGTL +
Sbjct: 569 -RAMRNITAVAGRDTLINCRVIGYPYYSIKWYK---DALLLPDNHRQ--VVFENGTLKLT 622
Query: 1917 KVQV-QDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAK 1975
VQ D G+Y+C+ L + + V V+ P ++ ++ +G + + C+
Sbjct: 623 DVQKGMDEGEYLCSVLIQPQLS-ISQSVHVAVKVPPLIQP-FEFPPASIGQLLYIPCVVS 680
Query: 1976 GTPAP-QISWIFPDRRVWQTVSPVEGRITLHENR---TLSIKEASFSDRGVYKCVASNAA 2031
P +I+W R+ Q + G +T+ +L I S G Y C+ASNAA
Sbjct: 681 SGDMPIRITW----RKDGQVIISGSG-VTIESKEFMSSLQISSVSLKHNGNYTCIASNAA 735
Query: 2032 GADSLAIRLHVAALPP--VIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI 2089
S +L + +PP V+ + I G+ ++C+ P P V W G+
Sbjct: 736 ATVSRERQL-IVRVPPRFVVQPNNQDGIYGKAGV---LNCSVDGYPPPKVMWKHAKGSG- 790
Query: 2090 RPSQF----LHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGS-ARRTVQLNVQRAAA 2144
P Q+ L G + + PN +L IR++ +D G Y C A+N VG+ +++ L V+ A
Sbjct: 791 NPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPA- 849
Query: 2145 NARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRL------PSKRMIDALFSFDSRI 2198
+ + P T G +L+C+A G+ I W P + M A+ + D+
Sbjct: 850 ---MITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGD 906
Query: 2199 KVFANGTLVVKSVTDKDAGDYLCVARNKVGDD--YVVLKVDVVMKPAKIEHKEENDHKVF 2256
+V + TL +K D+ + C A N G+D + L V P ++E +E +
Sbjct: 907 EVVS--TLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMN 964
Query: 2257 YGGDLKVD--CVATGLP----NPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLY 2310
+ D + TG N SW F QS + T
Sbjct: 965 LRWTQRFDGNSIITGFDIEYKNKSDSWD---------FKQSTRNISPTINQA-------- 1007
Query: 2311 FNEVGMREEGDYTC--FAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVAC 2368
N V + Y+ ++ N++G+ E + + T A P G + V
Sbjct: 1008 -NIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAA-----------PDGPPMDVTL 1055
Query: 2369 EAKGEPMPKVTWLSPTNKVIPTSSEKYQI-YQDGT-------LLIQKAQRSDSGNYTC-- 2418
+ +VTW +P ++ YQI Y++ + +++ DS YT
Sbjct: 1056 QPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDN 1115
Query: 2419 -----------LVRNSAG------EDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSR 2461
N AG E T V QPP+ N ++ ++A
Sbjct: 1116 LKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPE---NVRALSITSDVAV---- 1168
Query: 2462 KLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRI---TVHGNGS-------------LDI 2505
+ W+ P L G R+ +++ +G +++
Sbjct: 1169 --------------ISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVEL 1214
Query: 2506 RSLRK--SDSVQLVCMARNEGGEARLILQLTVLEPMEKP---------------IFHDPI 2548
R + K + SVQ++ + G +L + E + P + P
Sbjct: 1215 RGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPP 1274
Query: 2549 SEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSS 2608
++ + +TI + +G P PS P Q R H G ++ +++
Sbjct: 1275 TKPNGVIRKYTIFCSSPGSGQPAPSEYETSPE-------QLFYRIAHLNRGQQYLLWVAA 1327
Query: 2609 VDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGR 2668
V + +E++ G P + V+ + ++LPC G
Sbjct: 1328 VTSAG-------RGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1380
Query: 2669 FSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIV 2728
WT + G + NGTL +R D G Y C G + ++V
Sbjct: 1381 VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV 1440
Query: 2729 IAYP--PRITSEPT 2740
P PR+T T
Sbjct: 1441 QVPPDQPRLTVSKT 1454
Score = 68.9 bits (167), Expect = 7e-11
Identities = 57/195 (29%), Positives = 82/195 (42%), Gaps = 17/195 (8%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSI--LSSGWLRIKSMEPSDSG 551
G LSC + S +I W +L PD SI LS+ L I S + S SG
Sbjct: 389 GSTVILSCALTGSPEFTIRWYRNTELVL------PDEAISIRGLSNETLLITSAQKSHSG 442
Query: 552 LYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSW 611
YQC A R + ++ T NPGE +L C A P ++W
Sbjct: 443 AYQCFA-TRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTW 501
Query: 612 ILPNRRIINDLANTSHVYMLPNGT----LSIPKVQVSDSGYYRCVAVNQQGADHFTVGIT 667
L + I+ D ++ ++ Y + +GT +++ Q+ D G YRC A N G+ + I
Sbjct: 502 ALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARIN 561
Query: 668 VTKKGSGLPSKRGRR 682
V G PS R R
Sbjct: 562 V----RGPPSIRAMR 572
Score = 65.1 bits (157), Expect = 9e-10
Identities = 60/209 (28%), Positives = 90/209 (43%), Gaps = 35/209 (16%)
Query: 1752 PTSPAPVMRERKVI---PGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPSTNLQNIPM 1808
PT P V+R+ + PGS G PAP T SP I
Sbjct: 1274 PTKPNGVIRKYTIFCSSPGS--------------GQPAPSEYET-----SPEQLFYRIAH 1314
Query: 1809 VSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAE 1868
++ Q + ++ ++V S+G + S PA G+ P + TV+
Sbjct: 1315 LNRGQQYLLWV-AAVTSAGRGNSSEKVTIE---PA------GKAPAKIISFGGTVTTPWM 1364
Query: 1869 TDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMC 1928
D PC + G P P V WTK S + + + R + NGTL++R V+ +D G Y C
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRL-IHTNGTLLLRAVKAEDSGYYTC 1423
Query: 1929 TASNLHGLDRMVV--LLSVTVQQPQILAS 1955
TA+N G D ++V L+ V QP++ S
Sbjct: 1424 TATNTGGFDTIIVNLLVQVPPDQPRLTVS 1452
Score = 49.3 bits (116), Expect = 5e-05
Identities = 25/76 (32%), Positives = 36/76 (47%)
Query: 593 ESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCV 652
+ V LPCN++ P + W + ++ H + NGTL + V+ DSGYY C
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
Query: 653 AVNQQGADHFTVGITV 668
A N G D V + V
Sbjct: 1425 ATNTGGFDTIIVNLLV 1440
Score = 45.4 bits (106), Expect = 8e-04
Identities = 40/141 (28%), Positives = 62/141 (43%), Gaps = 19/141 (13%)
Query: 468 TRQARGRSW--VMIEPSGAVQRDQTVLEGGPC--------QLSCNVKASESPSIFWVLP- 516
T RG S V IEP+G + + GG +L CN +P++ W
Sbjct: 1329 TSAGRGNSSEKVTIEPAGKAPA-KIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDS 1387
Query: 517 DGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPS 576
+ S + MD I ++G L +++++ DSG Y C A D ++ +LVQ P
Sbjct: 1388 EDSAIPVSMD---GHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444
Query: 577 TQPAEKDTVTIGKNPGESVTL 597
QP +T+ K S+TL
Sbjct: 1445 DQP----RLTVSKTSASSITL 1461
Score = 45.1 bits (105), Expect = 0.001
Identities = 40/165 (24%), Positives = 69/165 (41%), Gaps = 22/165 (13%)
Query: 2659 CTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGT---LTVREASVFDRGTYVCRMET 2715
C+ PG+GQ P+ Q R++ L+ G L V + RG ++
Sbjct: 1288 CSSPGSGQ-----PAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTI 1342
Query: 2716 EYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHL 2775
E P +I++ +T TP + V+L C ++G P + W K
Sbjct: 1343 E---PAGKAPAKIISFGGTVT---TPWM-----KDVRLPCNSVGDPAPAVKWT---KDSE 1388
Query: 2776 KAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDS 2820
+ + + G+R +H G+L ++ D+G+Y C A N G D+
Sbjct: 1389 DSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDT 1433
Score = 43.5 bits (101), Expect = 0.003
Identities = 42/169 (24%), Positives = 68/169 (40%), Gaps = 14/169 (8%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ 558
+ C V + + P DG ++ + +SS L+I S+ +G Y CIA
Sbjct: 675 IPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS--LQISSVSLKHNGNYTCIAS 732
Query: 559 VRDEMDRMVYRVLVQSPS---TQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILP- 614
+++V+ P QP +D + G++ L C+ P + W
Sbjct: 733 NAAATVSRERQLIVRVPPRFVVQPNNQDGIY-----GKAGVLNCSVDGYPPPKVMWKHAK 787
Query: 615 ---NRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD 660
N + + + T + +LPN +L I V D GYY C A N G D
Sbjct: 788 GSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTD 836
Score = 39.7 bits (91), Expect = 0.043
Identities = 49/197 (24%), Positives = 74/197 (37%), Gaps = 22/197 (11%)
Query: 477 VMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIF---WVLPDGSILKAPMDDPDSKFS 533
V EP DQ + G C + +S + W SI+ P+ +F
Sbjct: 182 VFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSII------PEHRFF 235
Query: 534 ILSSGWLRIKSMEPSDS-GLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEK-DTVTIGKNP 591
I G L I ++ D+ Y+CI + + + S T PAE T+ G +
Sbjct: 236 ITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSV-TDPAESIPTILDGFHS 294
Query: 592 -----GESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDS 646
G +V LPC A P + W+ R + D T + L+I ++ DS
Sbjct: 295 QEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI-----TGLTISDLRTEDS 349
Query: 647 GYYRCVAVNQQGADHFT 663
G Y C N G+ T
Sbjct: 350 GTYICEVTNTFGSAEAT 366
Score = 38.9 bits (89), Expect = 0.073
Identities = 35/172 (20%), Positives = 66/172 (38%), Gaps = 10/172 (5%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILK--APMDDPDSKFSILSSGWLRIKSM 545
++ V G L C K + P++ W L D I++ + + + + + +
Sbjct: 476 EKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGP 535
Query: 546 EPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP 605
+ D G+Y+C A+ R+ V+ P + A ++ + G + C + P
Sbjct: 536 QIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVA---GRDTLINCRVIGYP 592
Query: 606 EAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVS-DSGYYRCVAVNQ 656
+ W + L + + NGTL + VQ D G Y C + Q
Sbjct: 593 YYSIKWY----KDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQ 640
Score = 38.1 bits (87), Expect = 0.12
Identities = 53/232 (22%), Positives = 89/232 (38%), Gaps = 20/232 (8%)
Query: 451 VLLSYYTQYSQTISTKDTRQARGRSWVM-IEPSGAVQ-RDQTVLEGGPCQLSCNVKASES 508
V L + Y+ S +R R ++ + P VQ +Q + G L+C+V
Sbjct: 719 VSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPP 778
Query: 509 PSIFWVLPDGS-----ILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ--VRD 561
P + W GS P+ + IL + L I+ + D G Y C A V
Sbjct: 779 PKVMWKHAKGSGNPQQYHPVPLT---GRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGT 835
Query: 562 EMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIIND 621
++ + ++ + V+ P+ + +T K G + L C A + W + I D
Sbjct: 836 DISKSMF-LTVKIPAMITSHPNTTIAIK--GHAKELNCTARGERPIIIRWEKGDTVIDPD 892
Query: 622 LANTSHVYMLPNG-----TLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
+ NG TL + DS ++ C A+N G D + +TV
Sbjct: 893 RVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTV 944
Score = 32.7 bits (73), Expect = 5.2
Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 12/81 (14%)
Query: 585 VTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQ-- 642
VT + G V +PC A P A L W L I D+ + HV+ NGTL +
Sbjct: 95 VTFSSSVG--VVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVH--ANGTLQLYPFSPS 150
Query: 643 -----VSDSGYYRCVAVNQQG 658
+ D+ Y+ C A N G
Sbjct: 151 AFNSFIHDNDYF-CTAENAAG 170
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 174 bits (441), Expect = 1e-42
Identities = 172/666 (25%), Positives = 259/666 (38%), Gaps = 67/666 (10%)
Query: 1814 SSISFIT-SSVQSSGSFHQSSSKFFAGGPPASKFWSLGEK-----PQILTKSPQTVSVTA 1867
SS+SF +Q SG+F + G S S K P +L +
Sbjct: 83 SSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQP 142
Query: 1868 ETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYM 1927
+T C G P+P W + T + + K L +R + G Y
Sbjct: 143 QTQVTLRCHIDGHPRPTYQWFRDGTPL---SDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
Query: 1928 CTASNLHG--LDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWI 1985
C A + G LS+ + + QDV V + C P P + W+
Sbjct: 200 CCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
Query: 1986 FPDRRVWQTVS--PVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS-LAIRLHV 2042
F D S P R T+ N +L + + + G+Y+C+ G L LH+
Sbjct: 260 FEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHL 319
Query: 2043 AAL-------PPVIHQEKLENIS-LPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQF 2094
A + P V E ++ LPP K P PSV W G ++
Sbjct: 320 AEIEDMPLFEPRVFTAGSEERVTCLPP----------KGLPEPSVWWEHA-GVRLPT--- 365
Query: 2095 LHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPR 2154
HG ++ L + N+A D+G Y C AANL G R+ V + V + + P+
Sbjct: 366 -HGRVYQ-KGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLK----KPQ 419
Query: 2155 RTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDK 2214
+ + G LDC P P ++W L S DSR +VF NGTL + SV
Sbjct: 420 DSQLEEGKPGYLDCLTQATPKPTVVWYRNQM-----LISEDSRFEVFKNGTLRINSVEVY 474
Query: 2215 DAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPE 2274
D Y C++ G +V V+ K K + + + + V C ATG P
Sbjct: 475 DGTWYRCMSSTPAGSIEAQARVQVLEK-LKFTPPPQPQQCMEFDKEATVPCSATGREKPT 533
Query: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
I W DGS + +V N GTL+F V + G+YTC A N + +
Sbjct: 534 IKWERADGSSL-------------PEWVTDNAGTLHFARVTRDDAGNYTCIASNGP-QGQ 579
Query: 2335 MRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTS-SE 2393
+R V++ A V G + CEA+G+P P + W + PT
Sbjct: 580 IRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGP 639
Query: 2394 KYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP-PKIN---GNPNPI 2449
+ I+Q+G+L+I DSG YTC+ NS ++V +P P+ + G+P P
Sbjct: 640 RMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPY 699
Query: 2450 TTVREI 2455
++ I
Sbjct: 700 KMIQTI 705
Score = 151 bits (382), Expect = 8e-36
Identities = 153/623 (24%), Positives = 250/623 (40%), Gaps = 56/623 (8%)
Query: 2019 DRGVYKCVASN-----AAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKA 2073
D G ++CVA + A + + + + PV+ + + P + + C
Sbjct: 95 DSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDG 154
Query: 2074 APLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARR 2133
P P+ +W DGT + Q H N TL R P+ SG Y C A + G A
Sbjct: 155 HPRPTYQW-FRDGTPLSDGQSNHTVSSKERNLTL--RPAGPEHSGLYSCCAHSAFGQACS 211
Query: 2134 TVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMID--AL 2191
+ + A + +P+ V C S P P + W + I +
Sbjct: 212 SQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSR 271
Query: 2192 FSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEEN 2251
R VFANG+L++ V ++AG Y C+ + + G ++ + + A+IE
Sbjct: 272 PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIIL---EATLHLAEIEDMPLF 328
Query: 2252 DHKVFYGG-DLKVDCVAT-GLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG-T 2308
+ +VF G + +V C+ GLP P + W L + GR V+ G
Sbjct: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRL--------PTHGR-----VYQKGHE 375
Query: 2309 LYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVAC 2368
L + + G YTC A N G+ V + V T P+ ++ Q+ G + C
Sbjct: 376 LVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQ--DSQLEEGKPGYLDC 433
Query: 2369 EAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDR 2428
+ P P V W N+++ + +++++++GTL I + D Y C+ AG
Sbjct: 434 LTQATPKPTVVWYR--NQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIE 491
Query: 2429 KTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPA 2488
+ V ++ K P P ++ + C A G P + W +G LP
Sbjct: 492 AQARVQV-LEKLKFTPPPQP----QQCMEFDKEATVPCSATGREKPTIKWERADGSSLPE 546
Query: 2489 PYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARN-EGGEARLILQLTVLEPMEKPIFHDP 2547
N T+H + + D+ C+A N G+ R +QLTV + + +P
Sbjct: 547 WVTDNAGTLH------FARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKV--EP 598
Query: 2548 ISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTD--LQSGQQLQRFYHKADGMLHISG 2605
E+ T GHT L C A G P P + W G D L + R + +G L I
Sbjct: 599 --ERTTVYQGHTALLQCEAQGDPKPLIQW---KGKDRILDPTKLGPRMHIFQNGSLVIHD 653
Query: 2606 LSSVDAGAYRCVARNAAG--HTE 2626
++ D+G Y C+A N+ HTE
Sbjct: 654 VAPEDSGRYTCIAGNSCNIKHTE 676
Score = 149 bits (377), Expect = 3e-35
Identities = 158/640 (24%), Positives = 254/640 (39%), Gaps = 99/640 (15%)
Query: 1919 QVQDRGQYMCTA-SNLHGLDRMVVLLSVTVQQ----PQILASHYQDVTVYLGDTIAMECL 1973
++QD G + C A ++ G + S ++ P +L + + + + C
Sbjct: 92 RLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCH 151
Query: 1974 AKGTPAPQISWI-----FPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS 2028
G P P W D + TVS E R L+++ A G+Y C A
Sbjct: 152 IDGHPRPTYQWFRDGTPLSDGQSNHTVSSKE--------RNLTLRPAGPEHSGLYSCCAH 203
Query: 2029 NAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSI-------HIHCTAKAAPLPSVRW 2081
+A G + ++ I E + L P + HC A P PS++W
Sbjct: 204 SAFGQACSSQNFTLS-----IADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQW 258
Query: 2082 VLGDGTQI----RPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQL 2137
+ D T I RP VF NG+L + + P+++G Y C+ G +R +
Sbjct: 259 LFEDETPITNRSRPPHLRRAT--VFANGSLLLTQVRPRNAGIYRCI-----GQGQRGPPI 311
Query: 2138 NVQRAAANARITGTSPRRTDVRYGGTL-KLDC-SASGDPWPRILWRLPSKRMIDALFSFD 2195
++ A I V G+ ++ C G P P + W R+
Sbjct: 312 ILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRL-------P 364
Query: 2196 SRIKVFANG-TLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHK 2254
+ +V+ G LV+ ++ + DAG Y C A N G + + V P+ + K+ D +
Sbjct: 365 THGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWL--KKPQDSQ 422
Query: 2255 VFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEV 2314
+ G +DC+ P P + W N + S+DS R+ VF NGTL N V
Sbjct: 423 LEEGKPGYLDCLTQATPKPTVVWYR------NQMLISEDS-----RFEVFKNGTLRINSV 471
Query: 2315 GMREEGDYTCFAENQVGKDEMRVRVKVV-----TAPATIRNKTYLAVQVPYGDVVTVACE 2369
+ + Y C + G E + RV+V+ T P + + + TV C
Sbjct: 472 EVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQ------CMEFDKEATVPCS 525
Query: 2370 AKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNS-AGEDR 2428
A G P + W +P ++ GTL + R D+GNYTC+ N G+ R
Sbjct: 526 ATGREKPTIKWERADGSSLP----EWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIR 581
Query: 2429 K------TVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPE 2482
V+I V+P + TTV + G L+ C+A+G P P + W +
Sbjct: 582 AHVQLTVAVFITFKVEPER--------TTVYQ----GHTALLQCEAQGDPKPLIQWKGKD 629
Query: 2483 GVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARN 2522
++ P G R+ + NGSL I + DS + C+A N
Sbjct: 630 RILDPTK-LGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGN 668
Score = 129 bits (324), Expect = 4e-29
Identities = 160/698 (22%), Positives = 263/698 (37%), Gaps = 83/698 (11%)
Query: 2067 IHCTAKAAPLPSVRWVLGDGTQIRPSQ--FLHGNLFVFPNGTLYIRNLAPKDSGRYECVA 2124
+ C +A V W+L DG ++ ++ F G+ F + L +DSG ++CVA
Sbjct: 51 LRCEVEAPGPVHVYWLL-DGAPVQDTERRFAQGSSLSFAA----VDRL--QDSGTFQCVA 103
Query: 2125 AN-LVGSARRTVQ--LNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR 2181
+ + G R+ N++ A + +++ + L C G P P W
Sbjct: 104 RDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWF 163
Query: 2182 LPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD-----DYVVLKV 2236
+ D + K L ++ + +G Y C A + G ++ +
Sbjct: 164 RDGTPLSDGQSNHTVSSK---ERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIA 220
Query: 2237 D-----VVMKPAKI---EHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSF 2288
D VV+ P + ++E H C + P P + W D + + +
Sbjct: 221 DESFARVVLAPQDVVVARYEEAMFH-----------CQFSAQPPPSLQWLFEDETPITNR 269
Query: 2289 MQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATI 2348
+ +R VF NG+L +V R G Y C + Q G + ++ A I
Sbjct: 270 SRPP----HLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPP---IILEATLHLAEI 322
Query: 2349 RNKTYLAVQV-PYGDVVTVAC-EAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQ 2406
+ +V G V C KG P P V W +PT YQ + L++
Sbjct: 323 EDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWW-EHAGVRLPTHGRVYQ--KGHELVLA 379
Query: 2407 KAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466
SD+G YTC N AG+ R+ V I V P + P + E G +DC
Sbjct: 380 NIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLK---KPQDSQLEEGKPG---YLDC 433
Query: 2467 KAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGE 2526
+ P P V+W + ++ +R V NG+L I S+ D CM+ G
Sbjct: 434 LTQATPKPTVVWYRNQMLISE----DSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGS 489
Query: 2527 ARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQS 2586
++ VLE ++ F P + ++ CSA G P++ W +
Sbjct: 490 IEAQARVQVLEKLK---FTPPPQPQQCMEFDKEATVPCSATGREKPTIKW------ERAD 540
Query: 2587 GQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAA-----GHTERLVSLKVGLKPEANK 2641
G L + G LH + ++ DAG Y C+A N H + V++ + K E +
Sbjct: 541 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600
Query: 2642 QYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLG-RVSLLDNGTLTVRE 2700
++ G T L C G + W + + P LG R+ + NG+L + +
Sbjct: 601 -----TTVYQGHTALLQCEAQGDPKPLIQWKGKD--RILDPTKLGPRMHIFQNGSLVIHD 653
Query: 2701 ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSE 2738
+ D G Y C T P+ V+ P SE
Sbjct: 654 VAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESE 691
Score = 129 bits (324), Expect = 4e-29
Identities = 123/482 (25%), Positives = 197/482 (40%), Gaps = 39/482 (8%)
Query: 1773 HSHSTFHLDFGPPAPPLLHTPQTTGSPSTNLQNIPMV--SSTQSSISFITSSVQSSGSFH 1830
+ + FH F PP L +P TN P + ++ ++ S + + V+ +
Sbjct: 239 YEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGI 298
Query: 1831 QSSSKFFAGGPPA--SKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWT 1888
GPP L E + P+ + +E + V G P+P V W
Sbjct: 299 YRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSE-ERVTCLPPKGLPEPSVWWE 357
Query: 1889 KVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQ 1948
G + + R+ + K LV+ + D G Y C A+NL G R V ++TV
Sbjct: 358 HA--GVRLPTHGRVYQ----KGHELVLANIAESDAGVYTCHAANLAGQRRQDV--NITVA 409
Query: 1949 QPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENR 2008
QD + G ++CL + TP P + W Q + + R + +N
Sbjct: 410 TVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRN-----QMLISEDSRFEVFKNG 464
Query: 2009 TLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAA----LPPVIHQEKLENISLPPGLS 2064
TL I D Y+C++S AG+ R+ V PP Q+ +E
Sbjct: 465 TLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDK-----E 519
Query: 2065 IHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVA 2124
+ C+A P+++W DG+ + +++ N GTL+ + D+G Y C+A
Sbjct: 520 ATVPCSATGREKPTIKWERADGSSL--PEWVTDNA-----GTLHFARVTRDDAGNYTCIA 572
Query: 2125 ANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPS 2184
+N + ++ +VQ A P RT V G T L C A GDP P I W+
Sbjct: 573 SN---GPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWK-GK 628
Query: 2185 KRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAK 2244
R++D R+ +F NG+LV+ V +D+G Y C+A N + + VV KP
Sbjct: 629 DRILDPT-KLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVP 687
Query: 2245 IE 2246
E
Sbjct: 688 EE 689
Score = 114 bits (285), Expect = 1e-24
Identities = 155/688 (22%), Positives = 261/688 (37%), Gaps = 83/688 (12%)
Query: 2153 PRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVT 2212
P D G L C + W L + D + FA G+ + +
Sbjct: 38 PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTE-------RRFAQGSSLSFAAV 90
Query: 2213 DK--DAGDYLCVARNKV-GDDYVVLKVDVVMK-----PAKIEHKEENDHKVFYGGDLKVD 2264
D+ D+G + CVAR+ V G++ +K P ++H ++ ++ + +
Sbjct: 91 DRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPA-SEAEIQPQTQVTLR 149
Query: 2265 CVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTC 2324
C G P P W DG+ + S G++ V L G G Y+C
Sbjct: 150 CHIDGHPRPTYQW-FRDGTPL--------SDGQSNHTVSSKERNLTLRPAGPEHSGLYSC 200
Query: 2325 FAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVA-------CEAKGEPMPK 2377
A + G+ +I ++++ V + DVV C+ +P P
Sbjct: 201 CAHSAFGQ-----ACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPS 255
Query: 2378 VTWLSP-----TNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVW 2432
+ WL TN+ P + ++ +G+LL+ + + ++G Y C+ + G +
Sbjct: 256 LQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPP---II 312
Query: 2433 IHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYG 2492
+ + +I P + R AG ++ +G+P P V W GV LP
Sbjct: 313 LEATLHLAEIEDMP--LFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHA-GVRLPTH--- 366
Query: 2493 NRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEP---MEKPIFHDPIS 2549
R+ G+ L + ++ +SD+ C A N G+ R + +TV ++KP D
Sbjct: 367 GRVYQKGH-ELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKP--QDSQL 423
Query: 2550 EKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSV 2609
E+ G L+C TP P++VW N + + + F +G L I+ +
Sbjct: 424 EE-----GKPGYLDCLTQATPKPTVVWYR-NQMLISEDSRFEVF---KNGTLRINSVEVY 474
Query: 2610 DAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRF 2669
D YRC++ AG E ++V K + + + +PC+ G +
Sbjct: 475 DGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTI 534
Query: 2670 SWTLPNGMHLEGPQTLGRVSLLDN-GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIV 2728
W +G L T DN GTL + D G Y C + + +
Sbjct: 535 KWERADGSSLPEWVT-------DNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLT 587
Query: 2729 IAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDK--SHLKAGVQARLYGN 2786
+A EP + G+T L C A G PK I W+ D+ K G + ++ N
Sbjct: 588 VAVFITFKVEPERTTVYQ-GHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQN 646
Query: 2787 RFLHPQGSLTIQHATQRDAGFYKCMAKN 2814
GSL I D+G Y C+A N
Sbjct: 647 ------GSLVIHDVAPEDSGRYTCIAGN 668
Score = 63.5 bits (153), Expect = 3e-09
Identities = 94/407 (23%), Positives = 152/407 (37%), Gaps = 40/407 (9%)
Query: 2440 PKINGNPNPITTVREI----AAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRI 2495
P + G I +++ A G R L+ C+ E V W AP
Sbjct: 23 PLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDG-----APVQDTER 77
Query: 2496 TVHGNGSLDIRSL-RKSDSVQLVCMARNE--GGEARLILQLTVLEPMEK-PIFHDPISEK 2551
SL ++ R DS C+AR++ G EAR ++ +E P+ + +
Sbjct: 78 RFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASE 137
Query: 2552 ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDA 2611
++L C G P P+ W +GT L GQ K + L + +
Sbjct: 138 AEIQPQTQVTLRCHIDGHPRPTYQW-FRDGTPLSDGQSNHTVSSK-ERNLTLRPAGPEHS 195
Query: 2612 GAYRCVARNAAGHTERLVSLKVGLKPEANKQY---HNLVSIINGETLKLPCT----PPGA 2664
G Y C A +A G + + + E+ + V + E C PP +
Sbjct: 196 GLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPS 255
Query: 2665 GQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSI 2724
Q F P + P L R ++ NG+L + + + G Y C + + GP
Sbjct: 256 LQWLFEDETPI-TNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGP----- 309
Query: 2725 PVIVIAYPPRITSEPTPVIYTR---PGNTVKLNCMA-MGIPKADITWELPDKSHLKAGVQ 2780
P+I+ A E P+ R G+ ++ C+ G+P+ + WE AGV+
Sbjct: 310 PIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWE-------HAGVR 362
Query: 2781 ARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+G R L + + + DAG Y C A N+ G + I V
Sbjct: 363 LPTHG-RVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITV 408
Score = 59.3 bits (142), Expect = 5e-08
Identities = 94/461 (20%), Positives = 169/461 (36%), Gaps = 34/461 (7%)
Query: 2368 CEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQR-SDSGNYTCLVRNSA-G 2425
CE + V WL P + + Q +L R DSG + C+ R+ G
Sbjct: 53 CEVEAPGPVHVYWLLDG---APVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTG 109
Query: 2426 EDRKTVWIHVNVQ----PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFP 2481
E+ ++ N++ P + +P ++ ++ + C +G P P W F
Sbjct: 110 EEARSANASFNIKWIEAGPVVLKHPASEAEIQP----QTQVTLRCHIDGHPRPTYQW-FR 164
Query: 2482 EGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEK 2541
+G L + N +L +R S C A + G+A T L ++
Sbjct: 165 DGTPL-SDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFT-LSIADE 222
Query: 2542 PIFHDPISEKITAMAGHTISL-NCSAAGTPTPSLVWVLPNGTDLQSGQQ---LQRFYHKA 2597
++ + +A + ++ +C + P PSL W+ + T + + + L+R A
Sbjct: 223 SFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFA 282
Query: 2598 DGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKL 2657
+G L ++ + +AG YRC+ + G L + + E + V E ++
Sbjct: 283 NGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEE-RV 341
Query: 2658 PCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEY 2717
C PP W G+ L T GRV + L + + D G Y C
Sbjct: 342 TCLPPKGLPEPSVWWEHAGVRLP---THGRVYQKGH-ELVLANIAESDAGVYTCHAANLA 397
Query: 2718 GPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKA 2777
G + + V P + + G L+C+ PK + W ++ +
Sbjct: 398 GQRRQDVNITVATVPSWLKKPQDSQL--EEGKPGYLDCLTQATPKPTVVWY---RNQMLI 452
Query: 2778 GVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
+R + G+L I D +Y+CM+ GS
Sbjct: 453 SEDSRFE----VFKNGTLRINSVEVYDGTWYRCMSSTPAGS 489
Score = 53.9 bits (128), Expect = 2e-06
Identities = 47/188 (25%), Positives = 78/188 (41%), Gaps = 24/188 (12%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
+D + EG P L C +A+ P++ W I + DS+F + +G LRI S+E
Sbjct: 419 QDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISE------DSRFEVFKNGTLRINSVE 472
Query: 547 PSDSGLYQCIA-----QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNA 601
D Y+C++ + + V L +P QP + + T+PC+A
Sbjct: 473 VYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQ------CMEFDKEATVPCSA 526
Query: 602 LAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVN-QQGAD 660
+ + W + + + + GTL +V D+G Y C+A N QG
Sbjct: 527 TGREKPTIKWERADGSSLPEWVTDN------AGTLHFARVTRDDAGNYTCIASNGPQGQI 580
Query: 661 HFTVGITV 668
V +TV
Sbjct: 581 RAHVQLTV 588
Score = 53.9 bits (128), Expect = 2e-06
Identities = 54/219 (24%), Positives = 87/219 (39%), Gaps = 12/219 (5%)
Query: 454 SYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFW 513
++Y S T + QAR + ++ + Q Q + + C+ E P+I W
Sbjct: 477 TWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKW 536
Query: 514 VLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMD-RMVYRVLV 572
DGS L + D ++G L + D+G Y CIA + R ++ V
Sbjct: 537 ERADGSSLPEWVTD--------NAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTV 588
Query: 573 QSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLP 632
T E + T+ + G + L C A P+ + W RI++ +++
Sbjct: 589 AVFITFKVEPERTTVYQ--GHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQ 645
Query: 633 NGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKK 671
NG+L I V DSG Y C+A N H + V K
Sbjct: 646 NGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK 684
Score = 43.5 bits (101), Expect = 0.003
Identities = 38/168 (22%), Positives = 66/168 (39%), Gaps = 15/168 (8%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSDSGLYQCIA 557
L C++ P+ W DG+ P+ D S ++ S L ++ P SGLY C A
Sbjct: 148 LRCHIDGHPRPTYQW-FRDGT----PLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCA 202
Query: 558 QVRD----EMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWIL 613
+ +S + V + + E C A P L W+
Sbjct: 203 HSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARY--EEAMFHCQFSAQPPPSLQWLF 260
Query: 614 PNRRIINDLANTSHVY---MLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ I + + H+ + NG+L + +V+ ++G YRC+ Q+G
Sbjct: 261 EDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
Score = 42.0 bits (97), Expect = 0.009
Identities = 49/190 (25%), Positives = 78/190 (41%), Gaps = 23/190 (12%)
Query: 489 QTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP- 547
Q L+G L C V+A ++W+L DG AP+ D + +F+ SS L +++
Sbjct: 41 QDALQGRRALLRCEVEAPGPVHVYWLL-DG----APVQDTERRFAQGSS--LSFAAVDRL 93
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGK-------NPGESVTLPCN 600
DSG +QC+A RD++ R S + + E V + P VTL C+
Sbjct: 94 QDSGTFQCVA--RDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCH 151
Query: 601 ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG-- 658
P W + + +N H L++ SG Y C A + G
Sbjct: 152 IDGHPRPTYQWFRDGTPLSDGQSN--HTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQA 209
Query: 659 --ADHFTVGI 666
+ +FT+ I
Sbjct: 210 CSSQNFTLSI 219
Score = 41.6 bits (96), Expect = 0.011
Identities = 52/216 (24%), Positives = 82/216 (37%), Gaps = 18/216 (8%)
Query: 462 TISTKDTRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSIL 521
T+S D AR V++ P +D V C A PS+ W+ D + +
Sbjct: 216 TLSIADESFAR----VVLAP-----QDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPI 266
Query: 522 KAPMDDPD-SKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVL-VQSPSTQP 579
P + ++ ++G L + + P ++G+Y+CI Q + ++ L + P
Sbjct: 267 TNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP 326
Query: 580 AEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIP 639
+ V + LP L PE + W R L VY + L +
Sbjct: 327 LFEPRVFTAGSEERVTCLPPKGL--PEPSVWWEHAGVR----LPTHGRVYQKGH-ELVLA 379
Query: 640 KVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGL 675
+ SD+G Y C A N G V ITV S L
Sbjct: 380 NIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWL 415
Score = 40.8 bits (94), Expect = 0.019
Identities = 36/133 (27%), Positives = 55/133 (41%), Gaps = 8/133 (6%)
Query: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQS-PSTQPAEKDTVTIGKNPGESVTLP 598
L + ++ SD+G+Y C A R + V + PS +D+ PG L
Sbjct: 376 LVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGY---LD 432
Query: 599 CNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
C A P+ + W I D S + NGTL I V+V D +YRC++ G
Sbjct: 433 CLTQATPKPTVVWYRNQMLISED----SRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAG 488
Query: 659 ADHFTVGITVTKK 671
+ + V +K
Sbjct: 489 SIEAQARVQVLEK 501
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 171 bits (434), Expect = 7e-42
Identities = 199/775 (25%), Positives = 316/775 (40%), Gaps = 71/775 (9%)
Query: 2041 HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF 2100
H PPVI ++ + + P I + C A P RW DG +P + L ++
Sbjct: 29 HHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWT-RDGVHFKPKEELGVTVY 87
Query: 2101 VFPNGTLYI-----RNLAPKDSGRYECVAANLVGSA-RRTVQLNVQRAAANARITGTSPR 2154
P+ + N A + G Y C A+N +G+A ++L + A + T +
Sbjct: 88 QSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKET---VK 144
Query: 2155 RTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSV-TD 2213
+V G ++ L C+ P ++ + SK + D R+ + NG L +V T
Sbjct: 145 PVEVEEGESVVLPCNPPPSAEPLRIYWMNSKIL---HIKQDERVTMGQNGNLYFANVLTS 201
Query: 2214 KDAGDYLCVA-----RNKVGDDYVVLKVD-----VVMKPAKIEHKEENDHKV-FYGGDLK 2262
+ DY+C A R + + + L+V + KP + + H V G L
Sbjct: 202 DNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLV 261
Query: 2263 VDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDY 2322
++C+A G P P I W P G + + + +N TL +VG ++G+Y
Sbjct: 262 LECIAEGFPTPTIKWLRPSGPMPADRVTYQN-----------HNKTLQLLKVGEEDDGEY 310
Query: 2323 TCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWL- 2381
C AEN +G V V AP + +K + P G+ + C+ +G P P+VTW
Sbjct: 311 RCLAENSLGSARHAYYVTVEAAPYWL-HKPQSHLYGP-GETARLDCQVQGRPQPEVTWRI 368
Query: 2382 --SPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP 2439
P ++ +KY+I Q G L++ Q SD+ C RN G +I+V P
Sbjct: 369 NGIPVEEL--AKDQKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 425
Query: 2440 PKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHG 2499
KI N +A GS + CKA G P P V W +G + R +
Sbjct: 426 AKILTADNQ----TYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTV---LQDERFFPYA 478
Query: 2500 NGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHT 2559
NG+L IR L+ +D+ + C+A N+ ++ L V + + I P S G
Sbjct: 479 NGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ--ITQGPRS--TIEKKGSR 534
Query: 2560 ISLNCSAAGTPT--PSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCV 2617
++ C A+ P+ PS+ W +G DLQ +++ + DG L I L D G Y CV
Sbjct: 535 VTFTCQASFDPSLQPSITW-RGDGRDLQELGDSDKYFIE-DGRLVIHSLDYSDQGNYSCV 592
Query: 2618 ARNAAGHTE-RLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPP---GAGQGRFSWTL 2673
A E R L VG + + + ++ +++ +P A ++
Sbjct: 593 ASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEF 652
Query: 2674 PN-GMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYP 2732
+ M E +LG+V N T T + S + T+ +YGP S PV
Sbjct: 653 EDKEMAPEKWYSLGKVP--GNQTSTTLKLSPYVHYTFRVTAINKYGPGEPS-PVSETVVT 709
Query: 2733 PRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNR 2787
P E PV GN N + P + W P ++ VQ R G R
Sbjct: 710 PEAAPEKNPVDVKGEGNET-TNMVITWKPLRWMDWNAP---QVQYRVQWRPQGTR 760
Score = 147 bits (371), Expect = 1e-34
Identities = 148/606 (24%), Positives = 231/606 (38%), Gaps = 83/606 (13%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWT--------KVSTGALMTPNTRI 1902
E P I +SP+ + V D CEA+GKP+ WT K G + +
Sbjct: 33 EPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHS 92
Query: 1903 QRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTV 1962
F + N + ++ Q G Y C ASN G + + P+ + V V
Sbjct: 93 GSFTITGNNSNFAQRFQ----GIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEV 148
Query: 1963 YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPV----EGRITLHENRTLSIKEASFS 2018
G+++ + C P P P R W + + R+T+ +N L S
Sbjct: 149 EEGESVVLPC----NPPPSAE---PLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTS 201
Query: 2019 DRGVYKCVASNAAGADSLA----IRLHVAALPPVIHQEKLENISLPPGLSIHI------- 2067
D ++ G ++ I L V A +I ++ + P S H+
Sbjct: 202 DNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMI--DRKPRLLFPTNSSSHLVALQGQP 259
Query: 2068 ---HCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNG--TLYIRNLAPKDSGRYEC 2122
C A+ P P+++W +RPS + + + N TL + + +D G Y C
Sbjct: 260 LVLECIAEGFPTPTIKW-------LRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRC 312
Query: 2123 VAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRL 2182
+A N +GSAR + V+ A P+ G T +LDC G P P + WR+
Sbjct: 313 LAENSLGSARHAYYVTVEAAPYWLH----KPQSHLYGPGETARLDCQVQGRPQPEVTWRI 368
Query: 2183 PSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKP 2242
+ + RI+ G L++ +V D C ARN+ G + VV P
Sbjct: 369 NGIPVEELAKDQKYRIQ---RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 425
Query: 2243 AKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYV 2302
AKI + + G + C A G P P + W DG+ V + +R+
Sbjct: 426 AKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL----------QDERFF 475
Query: 2303 VFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAP-------ATIRNKTYLA 2355
+ NGTL ++ + G Y C A N + +KV A +TI K
Sbjct: 476 PYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKK---- 531
Query: 2356 VQVPYGDVVTVACEAKGEP--MPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDS 2413
G VT C+A +P P +TW + +DG L+I SD
Sbjct: 532 -----GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ 586
Query: 2414 GNYTCL 2419
GNY+C+
Sbjct: 587 GNYSCV 592
Score = 142 bits (359), Expect = 4e-33
Identities = 164/607 (27%), Positives = 261/607 (42%), Gaps = 72/607 (11%)
Query: 1947 VQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISW------IFPDRRVWQTV--SPV 1998
++ P I + + V+ D I+++C A G P Q W P + TV SP
Sbjct: 32 MEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPH 91
Query: 1999 EGRITLHENRTLSIKEASFSDR--GVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLE 2055
G T+ N ++F+ R G+Y+C ASN G A S IRL +A P +E ++
Sbjct: 92 SGSFTITGN------NSNFAQRFQGIYRCFASNKLGTAMSHEIRL-MAEGAPKWPKETVK 144
Query: 2056 NISLPPGLSIHIHCTAKAAPLP-SVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAP 2114
+ + G S+ + C + P + W+ I+ + + + NG LY N+
Sbjct: 145 PVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDE----RVTMGQNGNLYFANVLT 200
Query: 2115 KDSGRYECVAANLVGSARRTVQ---LNVQRAAANARI---------TGTSPRRTDVRYGG 2162
D+ A+ G+ R +Q ++++ A N+ I T +S ++ G
Sbjct: 201 SDNHSDYICHAHFPGT-RTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ-GQ 258
Query: 2163 TLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCV 2222
L L+C A G P P I W PS M ++ + N TL + V ++D G+Y C+
Sbjct: 259 PLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNH-----NKTLQLLKVGEEDDGEYRCL 313
Query: 2223 ARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDG 2282
A N +G V V P + HK ++ H G ++DC G P PE++W + +G
Sbjct: 314 AENSLGSARHAYYVTVEAAPYWL-HKPQS-HLYGPGETARLDCQVQGRPQPEVTWRI-NG 370
Query: 2283 SLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVV 2342
V + ++Y + G L + V + C A N+ G + VV
Sbjct: 371 IPVEEL-------AKDQKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV 422
Query: 2343 TAPA---TIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQ 2399
PA T N+TY+AVQ G + C+A G P+P V WL + E++ Y
Sbjct: 423 QLPAKILTADNQTYMAVQ---GSTAYLLCKAFGAPVPSVQWLDEDGTTV-LQDERFFPYA 478
Query: 2400 DGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKING-NPNPITTVREIAAG 2458
+GTL I+ Q +D+G Y CL N D+ V I N++ P +T+ +
Sbjct: 479 NGTLGIRDLQANDTGRYFCLAAN----DQNNVTIMANLKVKDATQITQGPRSTIEK---K 531
Query: 2459 GSRKLIDCKAEGIPT--PRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQL 2516
GSR C+A P+ P + W +G L ++ + +G L I SL SD
Sbjct: 532 GSRVTFTCQASFDPSLQPSITWR-GDGRDLQELGDSDKYFIE-DGRLVIHSLDYSDQGNY 589
Query: 2517 VCMARNE 2523
C+A E
Sbjct: 590 SCVASTE 596
Score = 122 bits (305), Expect = 7e-27
Identities = 149/607 (24%), Positives = 239/607 (39%), Gaps = 69/607 (11%)
Query: 2239 VMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWS------LPDGSLVNSFMQSD 2292
VM+P I + VF D+ + C A+G P + W+ P L + QS
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 90
Query: 2293 DSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKD-EMRVRVKVVTAPATIRNK 2351
SG T + NN + R +G Y CFA N++G +R+ AP + +
Sbjct: 91 HSGSFT---ITGNN-----SNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPK-E 141
Query: 2352 TYLAVQVPYGDVVTVACE--AKGEPMPKVTWLSPTNKVIP-TSSEKYQIYQDGTLLIQKA 2408
T V+V G+ V + C EP+ ++ W++ +K++ E+ + Q+G L
Sbjct: 142 TVKPVEVEEGESVVLPCNPPPSAEPL-RIYWMN--SKILHIKQDERVTMGQNGNLYFANV 198
Query: 2409 QRSDS-GNYTCLVRNSAGE---DRKTVWIHVNVQPPKINGNPNPI----TTVREIAAGGS 2460
SD+ +Y C ++ + + V I+ P + ++ +A G
Sbjct: 199 LTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQ 258
Query: 2461 RKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHG-NGSLDIRSLRKSDSVQLVCM 2519
+++C AEG PTP + W P G P +R+T N +L + + + D + C+
Sbjct: 259 PLVLECIAEGFPTPTIKWLRPSG-----PMPADRVTYQNHNKTLQLLKVGEEDDGEYRCL 313
Query: 2520 ARNEGGEARLILQLTVLEP---MEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVW 2576
A N G AR +TV + KP H G T L+C G P P + W
Sbjct: 314 AENSLGSARHAYYVTVEAAPYWLHKPQSH-------LYGPGETARLDCQVQGRPQPEVTW 366
Query: 2577 VLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTER-----LVSL 2631
+ NG ++ + Q+ Y G L +S + D +C ARN G +V L
Sbjct: 367 RI-NGIPVEELAKDQK-YRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL 424
Query: 2632 KVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLL 2691
+ N+ Y + G T L C GA W +G + + R
Sbjct: 425 PAKILTADNQTY----MAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDE---RFFPY 477
Query: 2692 DNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTV 2751
NGTL +R+ D G Y C + +VT + + + +IT P I + G+ V
Sbjct: 478 ANGTLGIRDLQANDTGRYFCLAANDQN-NVTIMANLKVKDATQITQGPRSTI-EKKGSRV 535
Query: 2752 KLNCMAMGIP--KADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYK 2809
C A P + ITW + + G +++ G L I D G Y
Sbjct: 536 TFTCQASFDPSLQPSITWRGDGRDLQELG-----DSDKYFIEDGRLVIHSLDYSDQGNYS 590
Query: 2810 CMAKNIL 2816
C+A L
Sbjct: 591 CVASTEL 597
Score = 118 bits (295), Expect = 9e-26
Identities = 146/648 (22%), Positives = 256/648 (39%), Gaps = 74/648 (11%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPF-VTWTKVSTGALMTPNTRIQRFEVLKNG 1911
P+ ++ + V V V PC +P + W + + + +R + +NG
Sbjct: 136 PKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMN----SKILHIKQDERVTMGQNG 191
Query: 1912 TLVIRKVQVQDR-GQYMC--------TASNLHGLD-RMVVLLSVTVQQPQIL--ASHYQD 1959
L V D Y+C T +D R+ S+ ++P++L +
Sbjct: 192 NLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSH 251
Query: 1960 VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSD 2019
+ G + +EC+A+G P P I W+ P + P + + N+TL + + D
Sbjct: 252 LVALQGQPLVLECIAEGFPTPTIKWLRPSGPM-----PADRVTYQNHNKTLQLLKVGEED 306
Query: 2020 RGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
G Y+C+A N+ G+ A + V A P +H K ++ PG + + C + P P V
Sbjct: 307 DGEYRCLAENSLGSARHAYYVTVEAAPYWLH--KPQSHLYGPGETARLDCQVQGRPQPEV 364
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
W + I + + G L + N+ P D+ +C A N G + V
Sbjct: 365 TWRING---IPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYV 421
Query: 2140 QRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIK 2199
+ A +T + V+ G T L C A G P P + W + D R
Sbjct: 422 VQLPAKI-LTADNQTYMAVQ-GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ----DERFF 475
Query: 2200 VFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGG 2259
+ANGTL ++ + D G Y C+A N + V + ++ +K A + G
Sbjct: 476 PYANGTLGIRDLQANDTGRYFCLAANDQNN--VTIMANLKVKDATQITQGPRSTIEKKGS 533
Query: 2260 DLKVDCVATGLPN--PEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
+ C A+ P+ P I+W DG + SD +Y + +G L + +
Sbjct: 534 RVTFTCQASFDPSLQPSITWR-GDGRDLQELGDSD-------KYFI-EDGRLVIHSLDYS 584
Query: 2318 EEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPK 2377
++G+Y+C A ++ E R ++ VV +P P +V + +
Sbjct: 585 DQGNYSCVASTELDVVESRAQLLVVGSPG------------PVPRLVLSDLHLLTQSQVR 632
Query: 2378 VTWLSPTNKVIPTSSEKYQI-YQDGTLLIQK--AQRSDSGNYTCLVRNSAGEDRKTVWIH 2434
V+W + P EKY I ++D + +K + GN T + + ++H
Sbjct: 633 VSWSPAEDHNAPI--EKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL------KLSPYVH 684
Query: 2435 VNVQPPKIN----GNPNPIT-TVREIAAGGSRKLIDCKAEGIPTPRVL 2477
+ IN G P+P++ TV A + +D K EG T ++
Sbjct: 685 YTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMV 732
Score = 85.9 bits (211), Expect = 5e-16
Identities = 79/299 (26%), Positives = 121/299 (40%), Gaps = 23/299 (7%)
Query: 1843 ASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRI 1902
A+ +W KPQ P TA D C+ G+P+P VTW G + +
Sbjct: 331 AAPYWL--HKPQSHLYGP---GETARLD----CQVQGRPQPEVTWR--INGIPVEELAKD 379
Query: 1903 QRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTV 1962
Q++ + + G L++ VQ D C A N HGL + V +IL + Q
Sbjct: 380 QKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMA 438
Query: 1963 YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGV 2022
G T + C A G P P + W+ D T + R + N TL I++ +D G
Sbjct: 439 VQGSTAYLLCKAFGAPVPSVQWLDED----GTTVLQDERFFPYANGTLGIRDLQANDTGR 494
Query: 2023 YKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAP--LPSVR 2080
Y C+A+N ++ L V + + + G + C A P PS+
Sbjct: 495 YFCLAANDQNNVTIMANLKVKDATQITQGPR--STIEKKGSRVTFTCQASFDPSLQPSIT 552
Query: 2081 WVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
W GDG ++ + + + +G L I +L D G Y CVA+ + QL V
Sbjct: 553 W-RGDGRDLQ--ELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV 608
Score = 70.5 bits (171), Expect = 2e-11
Identities = 76/311 (24%), Positives = 123/311 (39%), Gaps = 35/311 (11%)
Query: 2539 MEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKA- 2597
ME P+ + ++ ISL C A+G P W +G + ++L +++
Sbjct: 32 MEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTR-DGVHFKPKEELGVTVYQSP 90
Query: 2598 -DGMLHISGLSSVDA----GAYRCVARNAAGHT-ERLVSLKVGLKPEANKQYHNLVSIIN 2651
G I+G +S A G YRC A N G + L P+ K+ V +
Sbjct: 91 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 150
Query: 2652 GETLKLPCTPPGAGQG-RFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGT-Y 2709
GE++ LPC PP + + R W +H++ + RV++ NG L D + Y
Sbjct: 151 GESVVLPCNPPPSAEPLRIYWMNSKILHIKQDE---RVTMGQNGNLYFANVLTSDNHSDY 207
Query: 2710 VCRMETEYGPSVTS---IPVIVIAYPPRITSEPTPVIYTRP--------GNTVKLNCMAM 2758
+C ++ I + V A I +P + T G + L C+A
Sbjct: 208 ICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAE 267
Query: 2759 GIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQ--HATQRDAGFYKCMAKNIL 2816
G P I W P + +R + + T+Q + D G Y+C+A+N L
Sbjct: 268 GFPTPTIKWLRPS---------GPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSL 318
Query: 2817 GSDSKTTYIHV 2827
GS Y+ V
Sbjct: 319 GSARHAYYVTV 329
Score = 57.8 bits (138), Expect = 2e-07
Identities = 46/164 (28%), Positives = 77/164 (46%), Gaps = 11/164 (6%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSG 551
++G L C + PS+ W+ DG+ + D +F ++G L I+ ++ +D+G
Sbjct: 439 VQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ-----DERFFPYANGTLGIRDLQANDTG 493
Query: 552 LYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP--EAHL 609
Y C+A D+ + + L +TQ + TI K G VT C A P + +
Sbjct: 494 RYFCLA-ANDQNNVTIMANLKVKDATQITQGPRSTIEKK-GSRVTFTCQASFDPSLQPSI 551
Query: 610 SWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
+W + R + +L + S Y + +G L I + SD G Y CVA
Sbjct: 552 TW-RGDGRDLQELGD-SDKYFIEDGRLVIHSLDYSDQGNYSCVA 593
Score = 53.9 bits (128), Expect = 2e-06
Identities = 45/168 (26%), Positives = 75/168 (44%), Gaps = 12/168 (7%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG-WLRIKSMEPSDS 550
L+G P L C + +P+I W+ P G PM P + + + L++ + D
Sbjct: 255 LQGQPLVLECIAEGFPTPTIKWLRPSG-----PM--PADRVTYQNHNKTLQLLKVGEEDD 307
Query: 551 GLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLS 610
G Y+C+A+ R Y V V++ + + G PGE+ L C P+ ++
Sbjct: 308 GEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYG--PGETARLDCQVQGRPQPEVT 365
Query: 611 WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
W + N + +LA Y + G L + VQ SD+ +C A N+ G
Sbjct: 366 WRI-NGIPVEELAK-DQKYRIQRGALILSNVQPSDTMVTQCEARNRHG 411
Score = 53.9 bits (128), Expect = 2e-06
Identities = 53/197 (26%), Positives = 82/197 (41%), Gaps = 27/197 (13%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDD--PDSKFSILSSGWLRIKSMEPSDSG 551
G +L C V+ P + W I P+++ D K+ I G L + +++PSD+
Sbjct: 347 GETARLDCQVQGRPQPEVTW-----RINGIPVEELAKDQKYRI-QRGALILSNVQPSDTM 400
Query: 552 LYQCIAQVRDEMDRM-VYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLS 610
+ QC A+ R + Y +VQ P+ + D T G + L C A P +
Sbjct: 401 VTQCEARNRHGLLLANAYIYVVQLPA-KILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQ 459
Query: 611 WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG------------ 658
W+ + + + NGTL I +Q +D+G Y C+A N Q
Sbjct: 460 WLDEDGTTV---LQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKD 516
Query: 659 ADHFTVG--ITVTKKGS 673
A T G T+ KKGS
Sbjct: 517 ATQITQGPRSTIEKKGS 533
Score = 41.2 bits (95), Expect = 0.015
Identities = 48/191 (25%), Positives = 77/191 (40%), Gaps = 22/191 (11%)
Query: 491 VLEGGPCQLSCNVKASESP-SIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
V EG L CN S P I+W+ + IL D+ + ++ +G L ++ SD
Sbjct: 148 VEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQDE---RVTMGQNGNLYFANVLTSD 202
Query: 550 SGL-YQCIAQ---VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP--------GESVTL 597
+ Y C A R + + + V++ ++ K + N G+ + L
Sbjct: 203 NHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVL 262
Query: 598 PCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQ 657
C A P + W+ P+ + D Y N TL + KV D G YRC+A N
Sbjct: 263 ECIAEGFPTPTIKWLRPSGPMPADRVT----YQNHNKTLQLLKVGEEDDGEYRCLAENSL 318
Query: 658 GADHFTVGITV 668
G+ +TV
Sbjct: 319 GSARHAYYVTV 329
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 171 bits (434), Expect = 7e-42
Identities = 199/775 (25%), Positives = 316/775 (40%), Gaps = 71/775 (9%)
Query: 2041 HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF 2100
H PPVI ++ + + P I + C A P RW DG +P + L ++
Sbjct: 29 HHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWT-RDGVHFKPKEELGVTVY 87
Query: 2101 VFPNGTLYI-----RNLAPKDSGRYECVAANLVGSA-RRTVQLNVQRAAANARITGTSPR 2154
P+ + N A + G Y C A+N +G+A ++L + A + T +
Sbjct: 88 QSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKET---VK 144
Query: 2155 RTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSV-TD 2213
+V G ++ L C+ P ++ + SK + D R+ + NG L +V T
Sbjct: 145 PVEVEEGESVVLPCNPPPSAEPLRIYWMNSKIL---HIKQDERVTMGQNGNLYFANVLTS 201
Query: 2214 KDAGDYLCVA-----RNKVGDDYVVLKVD-----VVMKPAKIEHKEENDHKV-FYGGDLK 2262
+ DY+C A R + + + L+V + KP + + H V G L
Sbjct: 202 DNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLV 261
Query: 2263 VDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDY 2322
++C+A G P P I W P G + + + +N TL +VG ++G+Y
Sbjct: 262 LECIAEGFPTPTIKWLRPSGPMPADRVTYQN-----------HNKTLQLLKVGEEDDGEY 310
Query: 2323 TCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWL- 2381
C AEN +G V V AP + +K + P G+ + C+ +G P P+VTW
Sbjct: 311 RCLAENSLGSARHAYYVTVEAAPYWL-HKPQSHLYGP-GETARLDCQVQGRPQPEVTWRI 368
Query: 2382 --SPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP 2439
P ++ +KY+I Q G L++ Q SD+ C RN G +I+V P
Sbjct: 369 NGIPVEEL--AKDQKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 425
Query: 2440 PKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHG 2499
KI N +A GS + CKA G P P V W +G + R +
Sbjct: 426 AKILTADNQ----TYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTV---LQDERFFPYA 478
Query: 2500 NGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHT 2559
NG+L IR L+ +D+ + C+A N+ ++ L V + + I P S G
Sbjct: 479 NGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ--ITQGPRS--TIEKKGSR 534
Query: 2560 ISLNCSAAGTPT--PSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCV 2617
++ C A+ P+ PS+ W +G DLQ +++ + DG L I L D G Y CV
Sbjct: 535 VTFTCQASFDPSLQPSITW-RGDGRDLQELGDSDKYFIE-DGRLVIHSLDYSDQGNYSCV 592
Query: 2618 ARNAAGHTE-RLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPP---GAGQGRFSWTL 2673
A E R L VG + + + ++ +++ +P A ++
Sbjct: 593 ASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEF 652
Query: 2674 PN-GMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYP 2732
+ M E +LG+V N T T + S + T+ +YGP S PV
Sbjct: 653 EDKEMAPEKWYSLGKVP--GNQTSTTLKLSPYVHYTFRVTAINKYGPGEPS-PVSETVVT 709
Query: 2733 PRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNR 2787
P E PV GN N + P + W P ++ VQ R G R
Sbjct: 710 PEAAPEKNPVDVKGEGNET-TNMVITWKPLRWMDWNAP---QVQYRVQWRPQGTR 760
Score = 147 bits (371), Expect = 1e-34
Identities = 148/606 (24%), Positives = 231/606 (38%), Gaps = 83/606 (13%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWT--------KVSTGALMTPNTRI 1902
E P I +SP+ + V D CEA+GKP+ WT K G + +
Sbjct: 33 EPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHS 92
Query: 1903 QRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTV 1962
F + N + ++ Q G Y C ASN G + + P+ + V V
Sbjct: 93 GSFTITGNNSNFAQRFQ----GIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEV 148
Query: 1963 YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPV----EGRITLHENRTLSIKEASFS 2018
G+++ + C P P P R W + + R+T+ +N L S
Sbjct: 149 EEGESVVLPC----NPPPSAE---PLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTS 201
Query: 2019 DRGVYKCVASNAAGADSLA----IRLHVAALPPVIHQEKLENISLPPGLSIHI------- 2067
D ++ G ++ I L V A +I ++ + P S H+
Sbjct: 202 DNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMI--DRKPRLLFPTNSSSHLVALQGQP 259
Query: 2068 ---HCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNG--TLYIRNLAPKDSGRYEC 2122
C A+ P P+++W +RPS + + + N TL + + +D G Y C
Sbjct: 260 LVLECIAEGFPTPTIKW-------LRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRC 312
Query: 2123 VAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRL 2182
+A N +GSAR + V+ A P+ G T +LDC G P P + WR+
Sbjct: 313 LAENSLGSARHAYYVTVEAAPYWLH----KPQSHLYGPGETARLDCQVQGRPQPEVTWRI 368
Query: 2183 PSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKP 2242
+ + RI+ G L++ +V D C ARN+ G + VV P
Sbjct: 369 NGIPVEELAKDQKYRIQ---RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLP 425
Query: 2243 AKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYV 2302
AKI + + G + C A G P P + W DG+ V + +R+
Sbjct: 426 AKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL----------QDERFF 475
Query: 2303 VFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAP-------ATIRNKTYLA 2355
+ NGTL ++ + G Y C A N + +KV A +TI K
Sbjct: 476 PYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKK---- 531
Query: 2356 VQVPYGDVVTVACEAKGEP--MPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDS 2413
G VT C+A +P P +TW + +DG L+I SD
Sbjct: 532 -----GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ 586
Query: 2414 GNYTCL 2419
GNY+C+
Sbjct: 587 GNYSCV 592
Score = 142 bits (359), Expect = 4e-33
Identities = 164/607 (27%), Positives = 261/607 (42%), Gaps = 72/607 (11%)
Query: 1947 VQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISW------IFPDRRVWQTV--SPV 1998
++ P I + + V+ D I+++C A G P Q W P + TV SP
Sbjct: 32 MEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPH 91
Query: 1999 EGRITLHENRTLSIKEASFSDR--GVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLE 2055
G T+ N ++F+ R G+Y+C ASN G A S IRL +A P +E ++
Sbjct: 92 SGSFTITGN------NSNFAQRFQGIYRCFASNKLGTAMSHEIRL-MAEGAPKWPKETVK 144
Query: 2056 NISLPPGLSIHIHCTAKAAPLP-SVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAP 2114
+ + G S+ + C + P + W+ I+ + + + NG LY N+
Sbjct: 145 PVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDE----RVTMGQNGNLYFANVLT 200
Query: 2115 KDSGRYECVAANLVGSARRTVQ---LNVQRAAANARI---------TGTSPRRTDVRYGG 2162
D+ A+ G+ R +Q ++++ A N+ I T +S ++ G
Sbjct: 201 SDNHSDYICHAHFPGT-RTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ-GQ 258
Query: 2163 TLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCV 2222
L L+C A G P P I W PS M ++ + N TL + V ++D G+Y C+
Sbjct: 259 PLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNH-----NKTLQLLKVGEEDDGEYRCL 313
Query: 2223 ARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDG 2282
A N +G V V P + HK ++ H G ++DC G P PE++W + +G
Sbjct: 314 AENSLGSARHAYYVTVEAAPYWL-HKPQS-HLYGPGETARLDCQVQGRPQPEVTWRI-NG 370
Query: 2283 SLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVV 2342
V + ++Y + G L + V + C A N+ G + VV
Sbjct: 371 IPVEEL-------AKDQKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV 422
Query: 2343 TAPA---TIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQ 2399
PA T N+TY+AVQ G + C+A G P+P V WL + E++ Y
Sbjct: 423 QLPAKILTADNQTYMAVQ---GSTAYLLCKAFGAPVPSVQWLDEDGTTV-LQDERFFPYA 478
Query: 2400 DGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKING-NPNPITTVREIAAG 2458
+GTL I+ Q +D+G Y CL N D+ V I N++ P +T+ +
Sbjct: 479 NGTLGIRDLQANDTGRYFCLAAN----DQNNVTIMANLKVKDATQITQGPRSTIEK---K 531
Query: 2459 GSRKLIDCKAEGIPT--PRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQL 2516
GSR C+A P+ P + W +G L ++ + +G L I SL SD
Sbjct: 532 GSRVTFTCQASFDPSLQPSITWR-GDGRDLQELGDSDKYFIE-DGRLVIHSLDYSDQGNY 589
Query: 2517 VCMARNE 2523
C+A E
Sbjct: 590 SCVASTE 596
Score = 122 bits (305), Expect = 7e-27
Identities = 149/607 (24%), Positives = 239/607 (39%), Gaps = 69/607 (11%)
Query: 2239 VMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWS------LPDGSLVNSFMQSD 2292
VM+P I + VF D+ + C A+G P + W+ P L + QS
Sbjct: 31 VMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 90
Query: 2293 DSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKD-EMRVRVKVVTAPATIRNK 2351
SG T + NN + R +G Y CFA N++G +R+ AP + +
Sbjct: 91 HSGSFT---ITGNN-----SNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPK-E 141
Query: 2352 TYLAVQVPYGDVVTVACE--AKGEPMPKVTWLSPTNKVIP-TSSEKYQIYQDGTLLIQKA 2408
T V+V G+ V + C EP+ ++ W++ +K++ E+ + Q+G L
Sbjct: 142 TVKPVEVEEGESVVLPCNPPPSAEPL-RIYWMN--SKILHIKQDERVTMGQNGNLYFANV 198
Query: 2409 QRSDS-GNYTCLVRNSAGE---DRKTVWIHVNVQPPKINGNPNPI----TTVREIAAGGS 2460
SD+ +Y C ++ + + V I+ P + ++ +A G
Sbjct: 199 LTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQ 258
Query: 2461 RKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHG-NGSLDIRSLRKSDSVQLVCM 2519
+++C AEG PTP + W P G P +R+T N +L + + + D + C+
Sbjct: 259 PLVLECIAEGFPTPTIKWLRPSG-----PMPADRVTYQNHNKTLQLLKVGEEDDGEYRCL 313
Query: 2520 ARNEGGEARLILQLTVLEP---MEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVW 2576
A N G AR +TV + KP H G T L+C G P P + W
Sbjct: 314 AENSLGSARHAYYVTVEAAPYWLHKPQSH-------LYGPGETARLDCQVQGRPQPEVTW 366
Query: 2577 VLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTER-----LVSL 2631
+ NG ++ + Q+ Y G L +S + D +C ARN G +V L
Sbjct: 367 RI-NGIPVEELAKDQK-YRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL 424
Query: 2632 KVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLL 2691
+ N+ Y + G T L C GA W +G + + R
Sbjct: 425 PAKILTADNQTY----MAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDE---RFFPY 477
Query: 2692 DNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTV 2751
NGTL +R+ D G Y C + +VT + + + +IT P I + G+ V
Sbjct: 478 ANGTLGIRDLQANDTGRYFCLAANDQN-NVTIMANLKVKDATQITQGPRSTI-EKKGSRV 535
Query: 2752 KLNCMAMGIP--KADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYK 2809
C A P + ITW + + G +++ G L I D G Y
Sbjct: 536 TFTCQASFDPSLQPSITWRGDGRDLQELG-----DSDKYFIEDGRLVIHSLDYSDQGNYS 590
Query: 2810 CMAKNIL 2816
C+A L
Sbjct: 591 CVASTEL 597
Score = 118 bits (295), Expect = 9e-26
Identities = 146/648 (22%), Positives = 256/648 (39%), Gaps = 74/648 (11%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPF-VTWTKVSTGALMTPNTRIQRFEVLKNG 1911
P+ ++ + V V V PC +P + W + + + +R + +NG
Sbjct: 136 PKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMN----SKILHIKQDERVTMGQNG 191
Query: 1912 TLVIRKVQVQDR-GQYMC--------TASNLHGLD-RMVVLLSVTVQQPQIL--ASHYQD 1959
L V D Y+C T +D R+ S+ ++P++L +
Sbjct: 192 NLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSH 251
Query: 1960 VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSD 2019
+ G + +EC+A+G P P I W+ P + P + + N+TL + + D
Sbjct: 252 LVALQGQPLVLECIAEGFPTPTIKWLRPSGPM-----PADRVTYQNHNKTLQLLKVGEED 306
Query: 2020 RGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
G Y+C+A N+ G+ A + V A P +H K ++ PG + + C + P P V
Sbjct: 307 DGEYRCLAENSLGSARHAYYVTVEAAPYWLH--KPQSHLYGPGETARLDCQVQGRPQPEV 364
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
W + I + + G L + N+ P D+ +C A N G + V
Sbjct: 365 TWRING---IPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYV 421
Query: 2140 QRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIK 2199
+ A +T + V+ G T L C A G P P + W + D R
Sbjct: 422 VQLPAKI-LTADNQTYMAVQ-GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ----DERFF 475
Query: 2200 VFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGG 2259
+ANGTL ++ + D G Y C+A N + V + ++ +K A + G
Sbjct: 476 PYANGTLGIRDLQANDTGRYFCLAANDQNN--VTIMANLKVKDATQITQGPRSTIEKKGS 533
Query: 2260 DLKVDCVATGLPN--PEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
+ C A+ P+ P I+W DG + SD +Y + +G L + +
Sbjct: 534 RVTFTCQASFDPSLQPSITWR-GDGRDLQELGDSD-------KYFI-EDGRLVIHSLDYS 584
Query: 2318 EEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPK 2377
++G+Y+C A ++ E R ++ VV +P P +V + +
Sbjct: 585 DQGNYSCVASTELDVVESRAQLLVVGSPG------------PVPRLVLSDLHLLTQSQVR 632
Query: 2378 VTWLSPTNKVIPTSSEKYQI-YQDGTLLIQK--AQRSDSGNYTCLVRNSAGEDRKTVWIH 2434
V+W + P EKY I ++D + +K + GN T + + ++H
Sbjct: 633 VSWSPAEDHNAPI--EKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL------KLSPYVH 684
Query: 2435 VNVQPPKIN----GNPNPIT-TVREIAAGGSRKLIDCKAEGIPTPRVL 2477
+ IN G P+P++ TV A + +D K EG T ++
Sbjct: 685 YTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMV 732
Score = 85.9 bits (211), Expect = 5e-16
Identities = 79/299 (26%), Positives = 121/299 (40%), Gaps = 23/299 (7%)
Query: 1843 ASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRI 1902
A+ +W KPQ P TA D C+ G+P+P VTW G + +
Sbjct: 331 AAPYWL--HKPQSHLYGP---GETARLD----CQVQGRPQPEVTWR--INGIPVEELAKD 379
Query: 1903 QRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTV 1962
Q++ + + G L++ VQ D C A N HGL + V +IL + Q
Sbjct: 380 QKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMA 438
Query: 1963 YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGV 2022
G T + C A G P P + W+ D T + R + N TL I++ +D G
Sbjct: 439 VQGSTAYLLCKAFGAPVPSVQWLDED----GTTVLQDERFFPYANGTLGIRDLQANDTGR 494
Query: 2023 YKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAP--LPSVR 2080
Y C+A+N ++ L V + + + G + C A P PS+
Sbjct: 495 YFCLAANDQNNVTIMANLKVKDATQITQGPR--STIEKKGSRVTFTCQASFDPSLQPSIT 552
Query: 2081 WVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
W GDG ++ + + + +G L I +L D G Y CVA+ + QL V
Sbjct: 553 W-RGDGRDLQ--ELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV 608
Score = 70.5 bits (171), Expect = 2e-11
Identities = 76/311 (24%), Positives = 123/311 (39%), Gaps = 35/311 (11%)
Query: 2539 MEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKA- 2597
ME P+ + ++ ISL C A+G P W +G + ++L +++
Sbjct: 32 MEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTR-DGVHFKPKEELGVTVYQSP 90
Query: 2598 -DGMLHISGLSSVDA----GAYRCVARNAAGHT-ERLVSLKVGLKPEANKQYHNLVSIIN 2651
G I+G +S A G YRC A N G + L P+ K+ V +
Sbjct: 91 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 150
Query: 2652 GETLKLPCTPPGAGQG-RFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGT-Y 2709
GE++ LPC PP + + R W +H++ + RV++ NG L D + Y
Sbjct: 151 GESVVLPCNPPPSAEPLRIYWMNSKILHIKQDE---RVTMGQNGNLYFANVLTSDNHSDY 207
Query: 2710 VCRMETEYGPSVTS---IPVIVIAYPPRITSEPTPVIYTRP--------GNTVKLNCMAM 2758
+C ++ I + V A I +P + T G + L C+A
Sbjct: 208 ICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAE 267
Query: 2759 GIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQ--HATQRDAGFYKCMAKNIL 2816
G P I W P + +R + + T+Q + D G Y+C+A+N L
Sbjct: 268 GFPTPTIKWLRPS---------GPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSL 318
Query: 2817 GSDSKTTYIHV 2827
GS Y+ V
Sbjct: 319 GSARHAYYVTV 329
Score = 57.8 bits (138), Expect = 2e-07
Identities = 46/164 (28%), Positives = 77/164 (46%), Gaps = 11/164 (6%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSG 551
++G L C + PS+ W+ DG+ + D +F ++G L I+ ++ +D+G
Sbjct: 439 VQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ-----DERFFPYANGTLGIRDLQANDTG 493
Query: 552 LYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP--EAHL 609
Y C+A D+ + + L +TQ + TI K G VT C A P + +
Sbjct: 494 RYFCLA-ANDQNNVTIMANLKVKDATQITQGPRSTIEKK-GSRVTFTCQASFDPSLQPSI 551
Query: 610 SWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
+W + R + +L + S Y + +G L I + SD G Y CVA
Sbjct: 552 TW-RGDGRDLQELGD-SDKYFIEDGRLVIHSLDYSDQGNYSCVA 593
Score = 53.9 bits (128), Expect = 2e-06
Identities = 45/168 (26%), Positives = 75/168 (44%), Gaps = 12/168 (7%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG-WLRIKSMEPSDS 550
L+G P L C + +P+I W+ P G PM P + + + L++ + D
Sbjct: 255 LQGQPLVLECIAEGFPTPTIKWLRPSG-----PM--PADRVTYQNHNKTLQLLKVGEEDD 307
Query: 551 GLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLS 610
G Y+C+A+ R Y V V++ + + G PGE+ L C P+ ++
Sbjct: 308 GEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYG--PGETARLDCQVQGRPQPEVT 365
Query: 611 WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
W + N + +LA Y + G L + VQ SD+ +C A N+ G
Sbjct: 366 WRI-NGIPVEELAK-DQKYRIQRGALILSNVQPSDTMVTQCEARNRHG 411
Score = 53.9 bits (128), Expect = 2e-06
Identities = 53/197 (26%), Positives = 82/197 (41%), Gaps = 27/197 (13%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDD--PDSKFSILSSGWLRIKSMEPSDSG 551
G +L C V+ P + W I P+++ D K+ I G L + +++PSD+
Sbjct: 347 GETARLDCQVQGRPQPEVTW-----RINGIPVEELAKDQKYRI-QRGALILSNVQPSDTM 400
Query: 552 LYQCIAQVRDEMDRM-VYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLS 610
+ QC A+ R + Y +VQ P+ + D T G + L C A P +
Sbjct: 401 VTQCEARNRHGLLLANAYIYVVQLPA-KILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQ 459
Query: 611 WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG------------ 658
W+ + + + NGTL I +Q +D+G Y C+A N Q
Sbjct: 460 WLDEDGTTV---LQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKD 516
Query: 659 ADHFTVG--ITVTKKGS 673
A T G T+ KKGS
Sbjct: 517 ATQITQGPRSTIEKKGS 533
Score = 41.2 bits (95), Expect = 0.015
Identities = 48/191 (25%), Positives = 77/191 (40%), Gaps = 22/191 (11%)
Query: 491 VLEGGPCQLSCNVKASESP-SIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
V EG L CN S P I+W+ + IL D+ + ++ +G L ++ SD
Sbjct: 148 VEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQDE---RVTMGQNGNLYFANVLTSD 202
Query: 550 SGL-YQCIAQ---VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP--------GESVTL 597
+ Y C A R + + + V++ ++ K + N G+ + L
Sbjct: 203 NHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVL 262
Query: 598 PCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQ 657
C A P + W+ P+ + D Y N TL + KV D G YRC+A N
Sbjct: 263 ECIAEGFPTPTIKWLRPSGPMPADRVT----YQNHNKTLQLLKVGEEDDGEYRCLAENSL 318
Query: 658 GADHFTVGITV 668
G+ +TV
Sbjct: 319 GSARHAYYVTV 329
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 171 bits (434), Expect = 7e-42
Identities = 123/394 (31%), Positives = 185/394 (46%), Gaps = 30/394 (7%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
E+P+I T PQ VT+ F C A G PKP + W + + M ++R+ +L +
Sbjct: 244 ERPRI-TSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRL---NLLDD 299
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHG--LDRMVVLLSVTVQQPQILASHYQDVTVYLGDTI 1968
GTL+I+ Q D+G Y C A N+ G + V L Q+ V +G+++
Sbjct: 300 GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESV 359
Query: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS 2028
+EC A G P P+ISW DR T PV+ R+ + + L I+ D G Y C A+
Sbjct: 360 TLECSATGHPPPRISWTRGDR----TPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
Query: 2029 NAAGADSLAIRLHVAALP--PVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDG 2086
N + + V ALP V Q+++ + G ++ C AK P P + W G G
Sbjct: 416 NNIDSVHATAFIIVQALPQFTVTPQDRV----VIEGQTVDFQCEAKGNPPPVIAWTKG-G 470
Query: 2087 TQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANA 2146
+Q+ + V +GTL I +A D G+YEC A N++GS + L VQ
Sbjct: 471 SQLSVDR----RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRV--T 524
Query: 2147 RITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTL 2206
+ + P T V G ++L CS+ G+P P I W ++ ++ + + G L
Sbjct: 525 PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTES-----GKFHISPEGFL 579
Query: 2207 VVKSVTDKDAGDYLCVARNKVGDDYV--VLKVDV 2238
+ V DAG Y CVARN +G V VL V+V
Sbjct: 580 TINDVGPADAGRYECVARNTIGSASVSMVLSVNV 613
Score = 161 bits (407), Expect = 1e-38
Identities = 114/414 (27%), Positives = 195/414 (47%), Gaps = 32/414 (7%)
Query: 2055 ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAP 2114
++ + G +++ C A+ P P + W+ + S L + +GTL I+N
Sbjct: 253 QDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNEL---SMKTDSRLNLLDDGTLMIQNTQE 309
Query: 2115 KDSGRYECVAANLVGSARRTVQLNVQRAAANARITGT-SPRRTDVRYGGTLKLDCSASGD 2173
D G Y+C+A N+ G + T ++ ++ + AR T P+ T+V G ++ L+CSA+G
Sbjct: 310 TDQGIYQCMAKNVAGEVK-TQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGH 368
Query: 2174 PWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVV 2233
P PRI W + + D R+ + +G L +++V D+G+Y C A N + D V
Sbjct: 369 PPPRISWTRGDRTPLPV----DPRVNITPSGGLYIQNVVQGDSGEYACSATNNI--DSVH 422
Query: 2234 LKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDD 2293
++++ D V G + C A G P P I+W+ L
Sbjct: 423 ATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL--------- 473
Query: 2294 SGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE----MRVRVKVVTAPATIR 2349
+R++V ++GTL + V + ++G Y C A N +G + + V+ +V A+I
Sbjct: 474 --SVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIP 531
Query: 2350 NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQ 2409
+ T + V G V + C ++GEP P +TW +V T S K+ I +G L I
Sbjct: 532 SDTTVEV----GANVQLPCSSQGEPEPAITWNKDGVQV--TESGKFHISPEGFLTINDVG 585
Query: 2410 RSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKL 2463
+D+G Y C+ RN+ G ++ + VNV NG+P T++ E A R +
Sbjct: 586 PADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAI 639
Score = 160 bits (405), Expect = 2e-38
Identities = 120/406 (29%), Positives = 189/406 (46%), Gaps = 33/406 (8%)
Query: 1948 QQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHEN 2007
++P+I S QD V G+T+ C A+G P P+I W+ R + + R+ L ++
Sbjct: 244 ERPRI-TSEPQDADVTSGNTVYFTCRAEGNPKPEIIWL---RNNNELSMKTDSRLNLLDD 299
Query: 2008 RTLSIKEASFSDRGVYKCVASNAAG---ADSLAIRLHVAALPPVIHQEKLENISLPPGLS 2064
TL I+ +D+G+Y+C+A N AG + +R + P + +N + G S
Sbjct: 300 GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQP-QNTEVLVGES 358
Query: 2065 IHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVA 2124
+ + C+A P P + W GD T + ++ + P+G LYI+N+ DSG Y C A
Sbjct: 359 VTLECSATGHPPPRISWTRGDRTPLPVDPRVN----ITPSGGLYIQNVVQGDSGEYACSA 414
Query: 2125 ANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPS 2184
N + S T + VQ A + T T R + G T+ C A G+P P I W
Sbjct: 415 TNNIDSVHATAFIIVQ---ALPQFTVTPQDRVVIE-GQTVDFQCEAKGNPPPVIAWTKGG 470
Query: 2185 KRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAK 2244
++ S D R V ++GTL + V D G Y C A N +G VV + V +
Sbjct: 471 SQL-----SVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTP 525
Query: 2245 IEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVF 2304
+ +D V G ++++ C + G P P I+W+ DG +Q +SG ++ +
Sbjct: 526 VFASIPSDTTVEVGANVQLPCSSQGEPEPAITWN-KDG------VQVTESG----KFHIS 574
Query: 2305 NNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRN 2350
G L N+VG + G Y C A N +G + + V V P RN
Sbjct: 575 PEGFLTINDVGPADAGRYECVARNTIGSASVSM-VLSVNVPDVSRN 619
Score = 131 bits (330), Expect = 8e-30
Identities = 103/395 (26%), Positives = 168/395 (42%), Gaps = 32/395 (8%)
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYT 2417
V G+ V C A+G P P++ WL N++ + + + DGTL+IQ Q +D G Y
Sbjct: 257 VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQ 316
Query: 2418 CLVRNSAGEDR-KTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRV 2476
C+ +N AGE + + V + P + P T E+ G S L +C A G P PR+
Sbjct: 317 CMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNT--EVLVGESVTL-ECSATGHPPPRI 373
Query: 2477 LWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVL 2536
W + LP R+ + +G L I+++ + DS + C A N + V
Sbjct: 374 SWTRGDRTPLPV---DPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIV- 429
Query: 2537 EPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQL---QRF 2593
P F +++ + G T+ C A G P P + W + G QL +R
Sbjct: 430 --QALPQFTVTPQDRV-VIEGQTVDFQCEAKGNPPPVIAWT-------KGGSQLSVDRRH 479
Query: 2594 YHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVS---II 2650
+ G L ISG++ D G Y C A N G + + L V +P + ++ S +
Sbjct: 480 LVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTV--QPRVTPVFASIPSDTTVE 537
Query: 2651 NGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYV 2710
G ++LPC+ G + +W E G+ + G LT+ + D G Y
Sbjct: 538 VGANVQLPCSSQGEPEPAITWNKDGVQVTES----GKFHISPEGFLTINDVGPADAGRYE 593
Query: 2711 CRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYT 2745
C G + S+ +++ P ++ P + T
Sbjct: 594 CVARNTIGSA--SVSMVLSVNVPDVSRNGDPFVAT 626
Score = 122 bits (305), Expect = 7e-27
Identities = 105/401 (26%), Positives = 170/401 (42%), Gaps = 38/401 (9%)
Query: 2435 VNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNR 2494
+N + P+I P G+ C+AEG P P ++W + + +R
Sbjct: 241 LNCERPRITSEPQDADVT-----SGNTVYFTCRAEGNPKPEIIWLRNNNEL--SMKTDSR 293
Query: 2495 ITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLI-LQLTVLEPMEKPIFHDPISEKIT 2553
+ + +G+L I++ +++D CMA+N GE + + L +P F +
Sbjct: 294 LNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ-PQNTE 352
Query: 2554 AMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGA 2613
+ G +++L CSA G P P + W + T L ++ G L+I + D+G
Sbjct: 353 VLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNI---TPSGGLYIQNVVQGDSGE 409
Query: 2614 YRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTL 2673
Y C A N + V P+ + V +I G+T+ C G +WT
Sbjct: 410 YACSATNNIDSVHATAFIIVQALPQFTVTPQDRV-VIEGQTVDFQCEAKGNPPPVIAWT- 467
Query: 2674 PNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPP 2733
G L + R +L +GTL + ++ D+G Y C+ G V + P
Sbjct: 468 KGGSQLSVDR---RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKV---VAHLTVQP 521
Query: 2734 RITSEPTPVIYTRPGNT-------VKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGN 2786
R+T PV + P +T V+L C + G P+ ITW K GVQ G
Sbjct: 522 RVT----PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWN-------KDGVQVTESGK 570
Query: 2787 RFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ P+G LTI DAG Y+C+A+N +GS S + + V
Sbjct: 571 FHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
Score = 100 bits (250), Expect = 2e-20
Identities = 76/247 (30%), Positives = 118/247 (47%), Gaps = 11/247 (4%)
Query: 1796 TGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQI 1855
T T L P V+ T S +I + VQ + S+ A+ F + PQ
Sbjct: 376 TRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQF 435
Query: 1856 LTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVI 1915
T +PQ V F CEA G P P + WTK G+ ++ + +R VL +GTL I
Sbjct: 436 -TVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK--GGSQLSVD---RRHLVLSSGTLRI 489
Query: 1916 RKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAK 1975
V + D+GQY C A N+ G ++V L+V + + AS D TV +G + + C ++
Sbjct: 490 SGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQ 549
Query: 1976 GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS 2035
G P P I+W +V ++ G+ + L+I + +D G Y+CVA N G+ S
Sbjct: 550 GEPEPAITWNKDGVQVTES-----GKFHISPEGFLTINDVGPADAGRYECVARNTIGSAS 604
Query: 2036 LAIRLHV 2042
+++ L V
Sbjct: 605 VSMVLSV 611
Score = 99.8 bits (247), Expect = 3e-20
Identities = 78/280 (27%), Positives = 124/280 (44%), Gaps = 50/280 (17%)
Query: 10 LSVVLILLWGHPRVAL-----ACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERINLGF 64
L++VL WG V CP C C+ + V C L +VPA +A ++L F
Sbjct: 14 LALVLFCAWGTLAVVAQKPGAGCPSRCLCF-RTTVRCMHLLLEAVPA-VAPQTSILDLRF 71
Query: 65 NSIQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQ 124
N I+ + +F L L L+++ N+I IP GA DL +L+ N+++ I Q +
Sbjct: 72 NRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFK 131
Query: 125 GLSNLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLST 184
GL++L +L++ N+IE + P +F L L L L N + L P TF+
Sbjct: 132 GLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFN------------ 179
Query: 185 IRHLYLAENMVRTLPASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILKCKKD 244
HL E+M R L L N CDCE+ W + +LK +
Sbjct: 180 --HL---ESMKR---------------LRLDSNTLHCDCEILWLAD-------LLKTYAE 212
Query: 245 KAYEGGQLCAMCFSPKKLYKHEIHKL--KDMTCLKPSIES 282
Q A+C P+++ + + +++ C +P I S
Sbjct: 213 SG--NAQAAAICEYPRRIQGRSVATITPEELNCERPRITS 250
Score = 73.9 bits (180), Expect = 2e-12
Identities = 60/216 (27%), Positives = 92/216 (42%), Gaps = 28/216 (12%)
Query: 469 RQARGRSWVMIEPSG---------AVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGS 519
R+ +GRS I P + +D V G +C + + P I W+ +
Sbjct: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNE 285
Query: 520 ILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIA-----QVRDEMDRMVYRVLVQS 574
+ DS+ ++L G L I++ + +D G+YQC+A +V+ + + Y
Sbjct: 286 LSMKT----DSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPAR 341
Query: 575 PS--TQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLP 632
P+ QP + + GESVTL C+A P +SW +R L V + P
Sbjct: 342 PTFVIQPQNTEVLV-----GESVTLECSATGHPPPRISWTRGDR---TPLPVDPRVNITP 393
Query: 633 NGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
+G L I V DSG Y C A N + H T I V
Sbjct: 394 SGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIV 429
Score = 68.9 bits (167), Expect = 7e-11
Identities = 55/187 (29%), Positives = 84/187 (44%), Gaps = 20/187 (10%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
+D+ V+EG C K + P I W GS L D + +LSSG LRI +
Sbjct: 440 QDRVVIEGQTVDFQCEAKGNPPPVIAWT-KGGSQLSV-----DRRHLVLSSGTLRISGVA 493
Query: 547 PSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPA-----EKDTVTIGKNPGESVTLPCNA 601
D G Y+C A ++V + VQ P P TV +G N V LPC++
Sbjct: 494 LHDQGQYECQAVNIIGSQKVVAHLTVQ-PRVTPVFASIPSDTTVEVGAN----VQLPCSS 548
Query: 602 LAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADH 661
PE ++W ++ + ++ P G L+I V +D+G Y CVA N G+
Sbjct: 549 QGEPEPAITWNKDGVQV----TESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSAS 604
Query: 662 FTVGITV 668
++ ++V
Sbjct: 605 VSMVLSV 611
Score = 65.5 bits (158), Expect = 7e-10
Identities = 61/211 (28%), Positives = 88/211 (41%), Gaps = 18/211 (8%)
Query: 481 PSGAVQRDQT-VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW 539
P+ +Q T VL G L C+ P I W D + L D + +I SG
Sbjct: 342 PTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPV-----DPRVNITPSGG 396
Query: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQS-PSTQPAEKDTVTIGKNPGESVTLP 598
L I+++ DSG Y C A + ++VQ+ P +D V I G++V
Sbjct: 397 LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVI---EGQTVDFQ 453
Query: 599 CNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVN--- 655
C A P ++W ++ D + +L +GTL I V + D G Y C AVN
Sbjct: 454 CEAKGNPPPVIAWTKGGSQLSVDRRHL----VLSSGTLRISGVALHDQGQYECQAVNIIG 509
Query: 656 -QQGADHFTVGITVTKKGSGLPSKRGRRPGA 685
Q+ H TV VT + +PS GA
Sbjct: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGA 540
Score = 42.0 bits (97), Expect = 0.009
Identities = 22/75 (29%), Positives = 37/75 (49%), Gaps = 6/75 (8%)
Query: 484 AVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIK 543
++ D TV G QL C+ + P+I W + ++ KF I G+L I
Sbjct: 529 SIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTES------GKFHISPEGFLTIN 582
Query: 544 SMEPSDSGLYQCIAQ 558
+ P+D+G Y+C+A+
Sbjct: 583 DVGPADAGRYECVAR 597
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 171 bits (432), Expect = 1e-41
Identities = 204/884 (23%), Positives = 349/884 (39%), Gaps = 91/884 (10%)
Query: 1972 CLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSI---KEASFSDR---GVYKC 2025
C A G P + W + + V G +H N TL I +SFS Y C
Sbjct: 46 CPAAGIPPVTLRWYLA---TGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYC 102
Query: 2026 VASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHC---TAKAAPLPSVRWV 2082
A N +G + +H+ A+ + ++E+ G C ++ A + V W
Sbjct: 103 TAENPSGKIR-SQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWE 161
Query: 2083 LGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDS-GRYECVAAN-LVGSARRT--VQLN 2138
+ + S+FL + G LYI+++ +D Y C+ + G R++ +L
Sbjct: 162 KDTVSLVSGSRFL-----ITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLF 216
Query: 2139 VQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRI 2198
V A +A G ++L C A G P P W + + R
Sbjct: 217 VSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPL-----ELSGRF 271
Query: 2199 KVFANGTLVVKSVTDKDAGDYLCVARNK------VGDDYVVLKVDVVMKPAKIEHKEEND 2252
+ G L+++++ D+G Y+C N+ +G YV + + P K+
Sbjct: 272 QKTVTG-LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKV------- 323
Query: 2253 HKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFN 2312
K G + + C TG + E+SW +G ++N G+ R N+ L +
Sbjct: 324 -KSSVGSQVSLSCSVTGTEDQELSW-YRNGEILNP--------GKNVRITGINHENLIMD 373
Query: 2313 EVGMREEGDYTCFAENQVGKDEMRVR--VKVVTAPATIRNKTYLAVQVPY-GDVVTVACE 2369
+ + G Y CF V KD++ + V+VV T + + + +V + V++ C
Sbjct: 374 HMVKSDGGAYQCF----VRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCN 429
Query: 2370 AKGEPMPKVTWLSPTNKVIPTSSEKYQ--IYQDGTLL----IQKAQRSDSGNYTCLVRNS 2423
KG P+P +TW + ++ S + I +G ++ I +Q D G Y C NS
Sbjct: 430 VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNS 489
Query: 2424 AGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEG 2483
AG +NV+ P + P+ + IA G I C+ G P + W
Sbjct: 490 AGV--VLYQARINVRGP---ASIRPMKNITAIA--GRDTYIHCRVIGYPYYSIKWYKNSN 542
Query: 2484 VVLPAPYYGNRITVHGNGSLDIRSLRKS-DSVQLVCMARNEGGEARLILQLTVLEPMEKP 2542
++ P+ ++ NG+L + ++K D + C N + +L +V ++ P
Sbjct: 543 LL---PFNHRQVAFENNGTLKLSDVQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVKVP 596
Query: 2543 IFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLH 2602
F P E G + + C P + +G + + L
Sbjct: 597 PFIQPF-EFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLR 655
Query: 2603 ISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPP 2662
IS LS + G Y C+ARN A E L V + P+ Q + I G+ + L C+
Sbjct: 656 ISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIY-GKAVILNCSAE 714
Query: 2663 GAGQGRFSWTLPNGMHLEGPQTL---GRVSLLDNGTLTVREASVFDRGTYVCRMETEYGP 2719
G W G + Q + GR+ +L NG+L ++ D G Y+C++ + G
Sbjct: 715 GYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGA 774
Query: 2720 SVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDK----SHL 2775
V+ + + P ITS P + T+ G +++C A G + WE D+
Sbjct: 775 DVSKSMYLTVKIPAMITSYPNTTLATQ-GQKKEMSCTAHGEKPIIVRWEKEDRIINPEMA 833
Query: 2776 KAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSD 2819
+ V + G + +L I + D+GF+ C A N G D
Sbjct: 834 RYLVSTKEVGEEVI---STLQILPTVREDSGFFSCHAINSYGED 874
Score = 163 bits (413), Expect = 2e-39
Identities = 185/706 (26%), Positives = 295/706 (41%), Gaps = 98/706 (13%)
Query: 1874 PCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNL 1933
PC+A G P+P W K + P RF+ G L+I ++ D G Y+C SN
Sbjct: 245 PCKALGHPEPDYRWLKDNM-----PLELSGRFQKTVTG-LLIENIRPSDSGSYVCEVSNR 298
Query: 1934 HGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQ 1993
+G +++ L V +QP + V +G +++ C GT ++SW R +
Sbjct: 299 YGTAKVIGRLYV--KQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWY----RNGE 352
Query: 1994 TVSPVEG-RITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAAL-----PP 2047
++P + RIT + L + SD G Y+C D L+ + +V + P
Sbjct: 353 ILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK----DKLSAQDYVQVVLEDGTPK 408
Query: 2048 VIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD-----GTQIRPSQFL--HGNLF 2100
+I + +S P + + C K PLP++ W L D G R SQ + GN+
Sbjct: 409 IISAFSEKVVS--PAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 466
Query: 2101 VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAA---NARITGTSPRRTD 2157
+ N I + +D G Y C A N G ++NV+ A+ IT + R T
Sbjct: 467 SYLN----ISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTY 522
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFAN-GTLVVKSVTDK-D 2215
+ C G P+ I W S L F+ R F N GTL + V + D
Sbjct: 523 IH--------CRVIGYPYYSIKWYKNSN-----LLPFNHRQVAFENNGTLKLSDVQKEVD 569
Query: 2216 AGDYLC--VARNKVGDD---YVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGL 2270
G+Y C + + ++ +V +KV ++P + + G + + CV
Sbjct: 570 EGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFP-------RFSIGQRVFIPCVVVSG 622
Query: 2271 PNP-EISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQ 2329
P I+W + S + D+ T +L + + + G+YTC A N+
Sbjct: 623 DLPITITWQKDGRPIPGSLGVTIDNIDFTS--------SLRISNLSLMHNGNYTCIARNE 674
Query: 2330 VGKDEMRVRVKVVTAPATI---RNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNK 2386
E + ++ V P + R++ + YG V + C A+G P+P + W
Sbjct: 675 AAAVEHQSQLIVRVPPKFVVQPRDQDGI-----YGKAVILNCSAEGYPVPTIVWKFSKGA 729
Query: 2387 VIP-----TSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGED-RKTVWIHVNVQPP 2440
+P + + Q+ +G+LLI+ DSG Y C V N G D K++++ V + P
Sbjct: 730 GVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKI-PA 788
Query: 2441 KINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLP--APYYGNRITVH 2498
I PN TT +A G +K + C A G V W + ++ P A Y + V
Sbjct: 789 MITSYPN--TT---LATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVG 843
Query: 2499 GN--GSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKP 2542
+L I + DS C A N GE R I+QLTV EP + P
Sbjct: 844 EEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP 889
Score = 150 bits (378), Expect = 2e-35
Identities = 210/843 (24%), Positives = 328/843 (38%), Gaps = 97/843 (11%)
Query: 1859 SPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALM--TPNTRIQRFEVLKNGTLVI- 1915
S Q V + T T+ PC A G P + W ++TG + P R V NGTL I
Sbjct: 30 SLQEVVFASTTGTLVPCPAAGIPPVTLRW-YLATGEEIYDVPGIR----HVHPNGTLQIF 84
Query: 1916 ------RKVQVQDRGQYMCTASNLHGLDR-MVVLLSVTVQQPQILASHYQDVTVYLGDTI 1968
+ D Y CTA N G R V + +++P + +D G+
Sbjct: 85 PFPPSSFSTLIHD-NTYYCTAENPSGKIRSQDVHIKAVLREPYTV--RVEDQKTMRGNVA 141
Query: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVEG-RITLHENRTLSIKEASFSDRGV--YKC 2025
+C+ + I+ + ++ TVS V G R + L IK+ D G+ Y+C
Sbjct: 142 VFKCIIPSSVEAYITVVSWEK---DTVSLVSGSRFLITSTGALYIKDVQNED-GLYNYRC 197
Query: 2026 VASNAAGAD---SLAIRLHVA----ALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPS 2078
+ + + S + RL V+ + P ++ + ++ G + + C A P P
Sbjct: 198 ITRHRYTGETRQSNSARLFVSDPANSAPSIL--DGFDHRKAMAGQRVELPCKALGHPEPD 255
Query: 2079 VRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLN 2138
RW L D + L G G L I N+ P DSG Y C +N G+A+ +L
Sbjct: 256 YRW-LKDNMPLE----LSGRFQKTVTG-LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLY 309
Query: 2139 VQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRI 2198
V++ SPR+ G + L CS +G + W + + + RI
Sbjct: 310 VKQPLK----ATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGK---NVRI 362
Query: 2199 KVFANGTLVVKSVTDKDAGDYLCVARNK--VGDDYVVLKVDVVMKPAKIEHKEENDHKVF 2256
+ L++ + D G Y C R DY V VV++ + KV
Sbjct: 363 TGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDY----VQVVLEDGTPKIISAFSEKVV 418
Query: 2257 YGGD-LKVDCVATGLPNPEISWSLPDGSLV----NSFMQSDDSGGRTKRYVVFNNGTLYF 2311
+ + + C G P P I+W+L D ++ + Q S G Y L
Sbjct: 419 SPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSY-------LNI 471
Query: 2312 NEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIR---NKTYLAVQVPYGDVVTVAC 2368
+ +R+ G Y C A N G + R+ V PA+IR N T +A + Y + C
Sbjct: 472 SSSQVRDGGVYRCTANNSAGVVLYQARIN-VRGPASIRPMKNITAIAGRDTY-----IHC 525
Query: 2369 EAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRS-DSGNYTC--LVRNSAG 2425
G P + W +N ++P + + +GTL + Q+ D G YTC LV+
Sbjct: 526 RVIGYPYYSIKWYKNSN-LLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLS 584
Query: 2426 EDRKTVWIHVNVQ-PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGV 2484
+ +HV V+ PP I P ++ G R I C P + +G
Sbjct: 585 TSQS---VHVTVKVPPFIQPFEFPRFSI------GQRVFIPCVVVSGDLPITITWQKDGR 635
Query: 2485 VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF 2544
+P + SL I +L + C+ARNE QL V P + +
Sbjct: 636 PIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVV- 694
Query: 2545 HDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQ---RFYHKADGML 2601
P + + G + LNCSA G P P++VW G + Q + R ++G L
Sbjct: 695 -QPRDQ--DGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSL 751
Query: 2602 HISGLSSVDAGAYRCVARNAAG-HTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCT 2660
I + D+G Y C N G + + L V + P Y N G+ ++ CT
Sbjct: 752 LIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKI-PAMITSYPNTTLATQGQKKEMSCT 810
Query: 2661 PPG 2663
G
Sbjct: 811 AHG 813
Score = 139 bits (349), Expect = 5e-32
Identities = 187/793 (23%), Positives = 305/793 (38%), Gaps = 84/793 (10%)
Query: 2067 IHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKD------SGRY 2120
+ C A P ++RW L G +I + G V PNGTL I P Y
Sbjct: 44 VPCPAAGIPPVTLRWYLATGEEIYD---VPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTY 100
Query: 2121 ECVAANLVGSAR-RTVQLN-VQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRI 2178
C A N G R + V + V R R+ R +V K +S + + +
Sbjct: 101 YCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNV---AVFKCIIPSSVEAYITV 157
Query: 2179 L-WRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDA-GDYLCVARNK-VGDDYVVLK 2235
+ W + ++ SR + + G L +K V ++D +Y C+ R++ G+
Sbjct: 158 VSWEKDTVSLVSG-----SRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNS 212
Query: 2236 VDV-VMKPAKIEHK--EENDH-KVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQS 2291
+ V PA + DH K G +++ C A G P P+ W + L
Sbjct: 213 ARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPL------- 265
Query: 2292 DDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTA-PATIRN 2350
+ GR ++ V L + + G Y C N+ G ++ R+ V ATI
Sbjct: 266 -ELSGRFQKTVT----GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP 320
Query: 2351 KTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQR 2410
+ V+ G V+++C G +++W + P + + L++ +
Sbjct: 321 RK---VKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVK 377
Query: 2411 SDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKL-IDCKAE 2469
SD G Y C VR +D+ + +V V +G P I+ E + + + C +
Sbjct: 378 SDGGAYQCFVR----KDKLSAQDYVQVVLE--DGTPKIISAFSEKVVSPAEPVSLMCNVK 431
Query: 2470 GIPTPRVLWAFPEGVVLPAPYY--GNRITVHGN--GSLDIRSLRKSDSVQLVCMARNEGG 2525
G P P + W + +L + IT GN L+I S + D C A N G
Sbjct: 432 GTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG 491
Query: 2526 EARLILQLTVLEPME-KPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
++ V P +P+ + ITA+AG ++C G P S+ W
Sbjct: 492 VVLYQARINVRGPASIRPM------KNITAIAGRDTYIHCRVIGYPYYSIKWY------- 538
Query: 2585 QSGQQLQRFYHKA-----DGMLHISGLSS-VDAGAYRC-VARNAAGHTERLVSLKVGLKP 2637
L F H+ +G L +S + VD G Y C V T + V + V + P
Sbjct: 539 -KNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPP 597
Query: 2638 EANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLT 2697
SI G+ + +PC +G + G + ++ +L
Sbjct: 598 FIQPFEFPRFSI--GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLR 655
Query: 2698 VREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPV--IYTRPGNTVKLNC 2755
+ S+ G Y C E +V +++ PP+ +P IY G V LNC
Sbjct: 656 ISNLSLMHNGNYTCIARNE-AAAVEHQSQLIVRVPPKFVVQPRDQDGIY---GKAVILNC 711
Query: 2756 MAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNI 2815
A G P I W+ + + L G + GSL I+H + D+G+Y C N
Sbjct: 712 SAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSND 771
Query: 2816 LGSD-SKTTYIHV 2827
+G+D SK+ Y+ V
Sbjct: 772 VGADVSKSMYLTV 784
Score = 134 bits (337), Expect = 1e-30
Identities = 201/849 (23%), Positives = 314/849 (36%), Gaps = 120/849 (14%)
Query: 1842 PASKFWSLGEKPQILTKSPQTVSVTAETD-----TVFPCEATGKPKPFVT---WTKVSTG 1893
P+ K S + + + P TV V + VF C + ++T W K T
Sbjct: 107 PSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEK-DTV 165
Query: 1894 ALMTPNTRIQRFEVLKNGTLVIRKVQVQDR-GQYMC-TASNLHGLDRMVVLLSVTVQQPQ 1951
+L++ + RF + G L I+ VQ +D Y C T G R + V P
Sbjct: 166 SLVSGS----RFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPA 221
Query: 1952 ILASHYQDV----TVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHEN 2007
A D G + + C A G P P W+ D + + +T
Sbjct: 222 NSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWL-KDNMPLELSGRFQKTVT---- 276
Query: 2008 RTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAA-LPPVIHQEKLENISLPPGLSIH 2066
L I+ SD G Y C SN G + RL+V L I K+++ G +
Sbjct: 277 -GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKS---SVGSQVS 332
Query: 2067 IHCTAKAAPLPSVRW-----VLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYE 2121
+ C+ + W +L G +R + H NL + ++ D G Y+
Sbjct: 333 LSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIM--------DHMVKSDGGAYQ 384
Query: 2122 CVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR 2181
C SA+ VQ+ ++ I+ S + V + L C+ G P P I W
Sbjct: 385 CFVRKDKLSAQDYVQVVLEDGTPKI-ISAFSEKV--VSPAEPVSLMCNVKGTPLPTITWT 441
Query: 2182 LPS-------KRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVL 2234
L I + + + + + N + S +D G Y C A N G
Sbjct: 442 LDDDPILKGGSHRISQMITSEGNVVSYLN----ISSSQVRDGGVYRCTANNSAGVVLYQA 497
Query: 2235 KVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDS 2294
+++V PA I + + G D + C G P I W L + Q
Sbjct: 498 RINV-RGPASI--RPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQ---- 550
Query: 2295 GGRTKRYVVF-NNGTLYFNEVGMR-EEGDYTC--FAENQVGKDEMRVRVKVVTAPA---- 2346
V F NNGTL ++V +EG+YTC + Q+ + V V V P
Sbjct: 551 -------VAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQS-VHVTVKVPPFIQPF 602
Query: 2347 -----TIRNKTYLAVQVPYGDV-VTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD 2400
+I + ++ V GD+ +T+ + G P+P ++ N +S
Sbjct: 603 EFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSS--------- 653
Query: 2401 GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGS 2460
L I +GNYTC+ RN A + V V PPK P + G
Sbjct: 654 --LRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRV-PPKFVVQPRDQDGIY-----GK 705
Query: 2461 RKLIDCKAEGIPTPRVLWAFPEGVVLPA--PYYGN-RITVHGNGSLDIRSLRKSDSVQLV 2517
+++C AEG P P ++W F +G +P P N RI V NGSL I+ + + DS +
Sbjct: 706 AVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYL 765
Query: 2518 CMARNE-GGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVW 2576
C N+ G + + LTV + P A G ++C+A G + W
Sbjct: 766 CKVSNDVGADVSKSMYLTV----KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRW 821
Query: 2577 VLPNGTDLQSGQQLQRFY-------HKADGMLHISGLSSVDAGAYRCVARNAAGHTERLV 2629
D ++ R+ + L I D+G + C A N+ G ++
Sbjct: 822 ---EKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGII 878
Query: 2630 SLKVGLKPE 2638
L V P+
Sbjct: 879 QLTVQEPPD 887
Score = 66.2 bits (160), Expect = 4e-10
Identities = 63/223 (28%), Positives = 90/223 (40%), Gaps = 32/223 (14%)
Query: 1872 VFPCEATGKPKPFVTWTKVSTGA---LMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMC 1928
+ C A G P P + W K S GA P R +VL NG+L+I+ V +D G Y+C
Sbjct: 708 ILNCSAEGYPVPTIVW-KFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLC 766
Query: 1929 TASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPD 1988
SN G D + + +TV+ P ++ S+ G M C A G + W D
Sbjct: 767 KVSNDVGAD-VSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKED 825
Query: 1989 RRVWQTVSPVEGRITLHENR-------TLSIKEASFSDRGVYKCVASNAAGADSLAIRLH 2041
R ++P R + TL I D G + C A N+ G D I+L
Sbjct: 826 R----IINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLT 881
Query: 2042 VAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLG 2084
V P PP + I KA + ++RW +G
Sbjct: 882 VQEPPD------------PPEIEIK---DVKARTI-TLRWTMG 908
Score = 63.9 bits (154), Expect = 2e-09
Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 7/111 (6%)
Query: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPN--TRIQRFE 1906
L + P + TV+ D V PC+A G P P V W K S G TP+ T R
Sbjct: 1281 LAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNG---TPSLVTIDGRRS 1337
Query: 1907 VLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTV--QQPQILAS 1955
+ NG+ +IR V+ +D G Y C A+N G D +++ L V V QP++ S
Sbjct: 1338 IFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVS 1388
Score = 60.5 bits (145), Expect = 2e-08
Identities = 36/106 (33%), Positives = 55/106 (51%), Gaps = 12/106 (11%)
Query: 2142 AAANARI-----TGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDS 2196
A A ARI T T+P D+ L C A GDP P + W S +L + D
Sbjct: 1282 AKAPARILTFSGTVTTPWMKDI------VLPCKAVGDPSPAVKWMKDSNGT-PSLVTIDG 1334
Query: 2197 RIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKP 2242
R +F+NG+ ++++V +D+G Y C+A N G D ++L + V + P
Sbjct: 1335 RRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
Score = 57.4 bits (137), Expect = 2e-07
Identities = 54/187 (28%), Positives = 77/187 (41%), Gaps = 14/187 (7%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG----WLRIK 543
++ V P L CNVK + P+I W L D ILK I S G +L I
Sbjct: 415 EKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQ--MITSEGNVVSYLNIS 472
Query: 544 SMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALA 603
S + D G+Y+C A + R+ V+ P++ K+ I G + C +
Sbjct: 473 SSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIA---GRDTYIHCRVIG 529
Query: 604 IPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVS-DSGYYRC-VAVNQQGADH 661
P + W N ++ N V NGTL + VQ D G Y C V V Q +
Sbjct: 530 YPYYSIKW-YKNSNLLP--FNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTS 586
Query: 662 FTVGITV 668
+V +TV
Sbjct: 587 QSVHVTV 593
Score = 57.0 bits (136), Expect = 3e-07
Identities = 50/189 (26%), Positives = 76/189 (40%), Gaps = 9/189 (4%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLY 553
G LSC+V +E + W +G IL + + + ++ L + M SD G Y
Sbjct: 328 GSQVSLSCSVTGTEDQELSWYR-NGEILNP---GKNVRITGINHENLIMDHMVKSDGGAY 383
Query: 554 QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWIL 613
QC + +D++ Y +V T +P E V+L CN P ++W L
Sbjct: 384 QCFVR-KDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTL 442
Query: 614 PNRRIINDLANTSHVYMLPNGT----LSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVT 669
+ I+ ++ + G L+I QV D G YRC A N G + I V
Sbjct: 443 DDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR 502
Query: 670 KKGSGLPSK 678
S P K
Sbjct: 503 GPASIRPMK 511
Score = 56.2 bits (134), Expect = 4e-07
Identities = 54/202 (26%), Positives = 88/202 (43%), Gaps = 15/202 (7%)
Query: 477 VMIEPSGAVQ-RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDP---DSKF 532
V + P VQ RDQ + G L+C+ + P+I W G+ P P + +
Sbjct: 686 VRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGA--GVPQFQPIALNGRI 743
Query: 533 SILSSGWLRIKSMEPSDSGLYQCIAQ--VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKN 590
+LS+G L IK + DSG Y C V ++ + +Y + V+ P+ + +T +
Sbjct: 744 QVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMY-LTVKIPAMITSYPNTTLATQ- 801
Query: 591 PGESVTLPCNALAIPEAHLSWILPNRRIINDLA----NTSHVYMLPNGTLSIPKVQVSDS 646
G+ + C A + W +R I ++A +T V TL I DS
Sbjct: 802 -GQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDS 860
Query: 647 GYYRCVAVNQQGADHFTVGITV 668
G++ C A+N G D + +TV
Sbjct: 861 GFFSCHAINSYGEDRGIIQLTV 882
Score = 54.3 bits (129), Expect = 2e-06
Identities = 53/202 (26%), Positives = 81/202 (40%), Gaps = 28/202 (13%)
Query: 2361 GDVVTVACEAKGEPMPKVTWLSPT--NKVIPTSSEKYQIYQDG---TLLIQKAQRSDSGN 2415
G V A M V+WL P N +I KY ++ T++ + DS +
Sbjct: 1190 GPPAGVKAAAASASMVFVSWLPPLKLNGII----RKYTVFCSHPYPTVISEFEASPDSFS 1245
Query: 2416 YTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKL------------ 2463
Y + N + + +VW+ + GN + I TV +A +R L
Sbjct: 1246 YR--IPNLSRNRQYSVWVVAVTSAGR--GNSSEIITVEPLAKAPARILTFSGTVTTPWMK 1301
Query: 2464 ---IDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMA 2520
+ CKA G P+P V W R ++ NGS IR+++ DS C+A
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
Query: 2521 RNEGGEARLILQLTVLEPMEKP 2542
N G +IL L V P ++P
Sbjct: 1362 NNNWGSDEIILNLQVQVPPDQP 1383
Score = 53.5 bits (127), Expect = 3e-06
Identities = 25/86 (29%), Positives = 45/86 (52%), Gaps = 2/86 (2%)
Query: 2356 VQVPYGDVVTVACEAKGEPMPKVTWLSPTNKV--IPTSSEKYQIYQDGTLLIQKAQRSDS 2413
V P+ + + C+A G+P P V W+ +N + T + I+ +G+ +I+ + DS
Sbjct: 1295 VTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDS 1354
Query: 2414 GNYTCLVRNSAGEDRKTVWIHVNVQP 2439
G Y+C+ N+ G D + + V V P
Sbjct: 1355 GYYSCIANNNWGSDEIILNLQVQVPP 1380
Score = 50.4 bits (119), Expect = 2e-05
Identities = 44/168 (26%), Positives = 69/168 (41%), Gaps = 13/168 (7%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ 558
+ C V + + P DG + + SS LRI ++ +G Y CIA+
Sbjct: 615 IPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSS--LRISNLSLMHNGNYTCIAR 672
Query: 559 VRDEMDRMVYRVLVQSPS---TQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPN 615
+++V+ P QP ++D + G++V L C+A P + W
Sbjct: 673 NEAAAVEHQSQLIVRVPPKFVVQPRDQDGIY-----GKAVILNCSAEGYPVPTIVWKFSK 727
Query: 616 RRII---NDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD 660
+ +A + +L NG+L I V DSGYY C N GAD
Sbjct: 728 GAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGAD 775
Score = 49.7 bits (117), Expect = 4e-05
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 1940 VVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVE 1999
++ + + P + + VT I + C A G P+P + W+ D ++ ++
Sbjct: 1275 IITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM-KDSNGTPSLVTID 1333
Query: 2000 GRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
GR ++ N + I+ D G Y C+A+N G+D + + L V P
Sbjct: 1334 GRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
Score = 48.1 bits (113), Expect = 1e-04
Identities = 36/124 (29%), Positives = 51/124 (41%), Gaps = 1/124 (0%)
Query: 2026 VASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD 2085
V S G S I + A P ++ P I + C A P P+V+W + D
Sbjct: 1264 VTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKW-MKD 1322
Query: 2086 GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAAN 2145
+ G +F NG+ IR + +DSG Y C+A N GS + L VQ
Sbjct: 1323 SNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQ 1382
Query: 2146 ARIT 2149
R+T
Sbjct: 1383 PRLT 1386
Score = 47.0 bits (110), Expect = 3e-04
Identities = 54/192 (28%), Positives = 77/192 (40%), Gaps = 22/192 (11%)
Query: 477 VMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIF---WVLPDGSILKAPMDDPDSKFS 533
V+ EP DQ + G C + +S I W S++ S+F
Sbjct: 121 VLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSG------SRFL 174
Query: 534 ILSSGWLRIKSMEPSDSGLY--QCIAQVR---DEMDRMVYRVLVQSPSTQ-PAEKDTVTI 587
I S+G L IK ++ D GLY +CI + R + R+ V P+ P+ D
Sbjct: 175 ITSTGALYIKDVQNED-GLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDH 233
Query: 588 GKN-PGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDS 646
K G+ V LPC AL PE W+ N + S + L I ++ SDS
Sbjct: 234 RKAMAGQRVELPCKALGHPEPDYRWLKDNMPL-----ELSGRFQKTVTGLLIENIRPSDS 288
Query: 647 GYYRCVAVNQQG 658
G Y C N+ G
Sbjct: 289 GSYVCEVSNRYG 300
Score = 46.6 bits (109), Expect = 3e-04
Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 6/99 (6%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ 558
L C SP++ W+ + D + SI S+G I++++ DSG Y CIA
Sbjct: 1305 LPCKAVGDPSPAVKWMKDSNGT--PSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
Query: 559 VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTL 597
D ++ + VQ P QP +T+ K S+TL
Sbjct: 1363 NNWGSDEIILNLQVQVPPDQP----RLTVSKTTSSSITL 1397
Score = 45.1 bits (105), Expect = 0.001
Identities = 47/196 (23%), Positives = 81/196 (41%), Gaps = 23/196 (11%)
Query: 465 TKDTRQARGRSWVMIEPSGAVQR------DQTVLEGGPCQLSCNVKASESPSIFWVLPDG 518
T +TRQ+ + +P+ + + + G +L C P W L D
Sbjct: 204 TGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRW-LKDN 262
Query: 519 SILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQ 578
L+ +F +G L I+++ PSDSG Y C R +++ R+ V+ P
Sbjct: 263 MPLEL-----SGRFQKTVTGLL-IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPL-- 314
Query: 579 PAEKDTVT---IGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGT 635
K T++ + + G V+L C+ + LSW N I+N N + + +
Sbjct: 315 ---KATISPRKVKSSVGSQVSLSCSVTGTEDQELSW-YRNGEILNPGKNV-RITGINHEN 369
Query: 636 LSIPKVQVSDSGYYRC 651
L + + SD G Y+C
Sbjct: 370 LIMDHMVKSDGGAYQC 385
Score = 45.1 bits (105), Expect = 0.001
Identities = 21/76 (27%), Positives = 36/76 (47%)
Query: 593 ESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCV 652
+ + LPC A+ P + W+ + + + + NG+ I V+ DSGYY C+
Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
Query: 653 AVNQQGADHFTVGITV 668
A N G+D + + V
Sbjct: 1361 ANNNWGSDEIILNLQV 1376
Score = 45.1 bits (105), Expect = 0.001
Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 7/86 (8%)
Query: 2260 DLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREE 2319
D+ + C A G P+P + W + D + S + D R +F+NG+ V +
Sbjct: 1302 DIVLPCKAVGDPSPAVKW-MKDSNGTPSLVTIDG------RRSIFSNGSFIIRTVKAEDS 1354
Query: 2320 GDYTCFAENQVGKDEMRVRVKVVTAP 2345
G Y+C A N G DE+ + ++V P
Sbjct: 1355 GYYSCIANNNWGSDEIILNLQVQVPP 1380
Score = 40.8 bits (94), Expect = 0.019
Identities = 31/109 (28%), Positives = 53/109 (48%), Gaps = 3/109 (2%)
Query: 2532 QLTVLEPMEK-PIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLP-NGTDLQSGQQ 2589
++ +EP+ K P S +T I L C A G P+P++ W+ NGT
Sbjct: 1274 EIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTID 1333
Query: 2590 LQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPE 2638
+R ++G I + + D+G Y C+A N G E +++L+V + P+
Sbjct: 1334 GRRSIF-SNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPD 1381
Score = 38.1 bits (87), Expect = 0.12
Identities = 34/117 (29%), Positives = 48/117 (41%), Gaps = 10/117 (8%)
Query: 1840 GPPASKFWSLGEK-PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTP 1898
G SK L K P ++T P T T C A G+ V W K ++ P
Sbjct: 773 GADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK--EDRIINP 830
Query: 1899 NTRIQRFEVLKNGTLVIRKVQV-----QDRGQYMCTASNLHGLDRMVVLLSVTVQQP 1950
+ G VI +Q+ +D G + C A N +G DR ++ L TVQ+P
Sbjct: 831 EMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQL--TVQEP 885
Score = 38.1 bits (87), Expect = 0.12
Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)
Query: 2751 VKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKC 2810
+ L C A+G P + W + D + + V + G R + GS I+ D+G+Y C
Sbjct: 1303 IVLPCKAVGDPSPAVKW-MKDSNGTPSLVT--IDGRRSIFSNGSFIIRTVKAEDSGYYSC 1359
Query: 2811 MAKNILGSD 2819
+A N GSD
Sbjct: 1360 IANNNWGSD 1368
Score = 36.6 bits (83), Expect = 0.36
Identities = 25/69 (36%), Positives = 30/69 (43%), Gaps = 10/69 (14%)
Query: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSI-------PKVQVSDSGYY 649
+PC A IP L W L I D+ HV+ PNGTL I + D+ YY
Sbjct: 44 VPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVH--PNGTLQIFPFPPSSFSTLIHDNTYY 101
Query: 650 RCVAVNQQG 658
C A N G
Sbjct: 102 -CTAENPSG 109
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 168 bits (426), Expect = 6e-41
Identities = 157/575 (27%), Positives = 240/575 (41%), Gaps = 76/575 (13%)
Query: 2039 RLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGN 2098
RL PP I E ++ + G ++C A+ P P++ W G +
Sbjct: 21 RLRQEDFPPRI-VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH 79
Query: 2099 LFVFPNGTLYIRNL-----APKDSGRYECVAANLVGSARRTVQLNVQRAAANARIT-GTS 2152
+ P+G+L+ + + D G Y CVA N +G A V N A R +
Sbjct: 80 RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEA---VSHNASLEVAILRDDFRQN 136
Query: 2153 PRRTDVRYGGTLKLDCSAS-GDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSV 2211
P V G ++C G P P I W+ + D D RI + G L++
Sbjct: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK----DERITI-RGGKLMITYT 191
Query: 2212 TDKDAGDYLCVARNKVGD-DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGL 2270
DAG Y+CV N VG+ + V ++ V+ +P+ + K ++ V + C A G
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGD 249
Query: 2271 PNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQV 2330
P P + W DG L S RY + ++ TL +V + G YTC AEN V
Sbjct: 250 PVPTVRWRKDDGELPKS------------RYEIRDDHTLKIRKVTAGDMGSYTCVAENMV 297
Query: 2331 GKDEMRVRVKVVTAPATIRNKTYLAVQ-----VPYGDVVTVACEAKGEPMPKVTWLSPTN 2385
GK E +A T++ + V+ V G VT CEA G P P + W +
Sbjct: 298 GKAE-------ASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS 350
Query: 2386 KVI------PTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHV---- 2435
+ + P SS ++ + Q G L I QRSD G Y C N AG ++ V
Sbjct: 351 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 410
Query: 2436 -NVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNR 2494
+ PP I P V + A ++ C A G P P +LW +GV++ +R
Sbjct: 411 ADRPPPVIRQGP-----VNQTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVST--QDSR 462
Query: 2495 ITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLE---PMEKP-------IF 2544
I NG L IR + D+ + C+A GEA + V E P++ P I
Sbjct: 463 IKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP 522
Query: 2545 HDPISEKITAMAGHTISL----NCSAAGTPTPSLV 2575
P ++T ++ +T++L N ++ TPT ++
Sbjct: 523 SAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII 557
Score = 154 bits (390), Expect = 9e-37
Identities = 138/511 (27%), Positives = 209/511 (40%), Gaps = 57/511 (11%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P + + P + V+ C+A G+P P + W K + +L +G+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 1913 LVIRKV-----QVQDRGQYMCTASNL------HGLDRMVVLLSVTVQQPQILASHYQDVT 1961
L ++ D G Y+C A N H V +L +Q + DV
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ------NPSDVM 141
Query: 1962 VYLGDTIAMECL-AKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDR 2020
V +G+ MEC +G P P ISW ++ + + RIT+ + L I SD
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGK-LMITYTRKSDA 196
Query: 2021 GVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
G Y CV +N G +S L V P + ++ N+++ S C A+ P+P+V
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTV 254
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
RW DG ++ S++ + + TL IR + D G Y CVA N+VG A + L V
Sbjct: 255 RWRKDDG-ELPKSRY-----EIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 2140 QRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSF----- 2194
Q PR V G T+ C A+G+P P I WR + + LFS+
Sbjct: 309 QEPPHFV----VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ--NLLFSYQPPQS 362
Query: 2195 DSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD----DYVVLKVDVVMKPAKIEHKEE 2250
SR V G L + +V D G Y+C N G Y+ + + +P + +
Sbjct: 363 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 422
Query: 2251 NDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLY 2310
+ V G + CVATG P P I W DG LV++ + R NG L
Sbjct: 423 VNQTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQ 472
Query: 2311 FNEVGMREEGDYTCFAENQVGKDEMRVRVKV 2341
+ + G YTC A G+ ++V
Sbjct: 473 IRYAKLGDTGRYTCIASTPSGEATWSAYIEV 503
Score = 141 bits (356), Expect = 8e-33
Identities = 134/509 (26%), Positives = 199/509 (39%), Gaps = 39/509 (7%)
Query: 1950 PQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV-WQTVSPVEGRITLHENR 2008
P + H D+ V G+ + C A+G P P I W RV P R+ L
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 2009 TLSIK----EASFSDRGVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGL 2063
++ S D GVY CVA N G A S L VA L Q ++ + G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP-SDVMVAVGE 146
Query: 2064 SIHIHC-TAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYEC 2122
+ C + P P++ W DG+ + G L I D+G+Y C
Sbjct: 147 PAVMECQPPRGHPEPTISW-KKDGSPLDDKD----ERITIRGGKLMITYTRKSDAGKYVC 201
Query: 2123 VAANLVGSARRTV-QLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR 2181
V N+VG V +L V + + P V + + C A GDP P + WR
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVK----RPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 2182 LPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMK 2241
+ SR ++ + TL ++ VT D G Y CVA N VG + V
Sbjct: 258 KDDGELP------KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 311
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P + + D V G + C ATG P P I W +GS + + S + R+
Sbjct: 312 PHFV--VKPRDQVVALGRTVTFQCEATGNPQPAIFWR-REGS--QNLLFSYQPPQSSSRF 366
Query: 2302 VVFNNGTLYFNEVGMREEGDYTCFAENQVG----KDEMRVRVKVVTAPATIRNKTYLAVQ 2357
V G L V + G Y C N G K + V + P + + +
Sbjct: 367 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 426
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYT 2417
V ++C A G P+P + W ++ T + + ++G L I+ A+ D+G YT
Sbjct: 427 VAVDGTFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 485
Query: 2418 CLVRNSAGEDRKTVWIHVN-----VQPPK 2441
C+ +GE + +I V VQPP+
Sbjct: 486 CIASTPSGEATWSAYIEVQEFGVPVQPPR 514
Score = 135 bits (339), Expect = 7e-31
Identities = 137/495 (27%), Positives = 199/495 (40%), Gaps = 56/495 (11%)
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLS-----PTNKVIPTSSEKYQIYQDGTLLIQKA---- 2408
V G+ T+ C+A+G P P + W T+K P S + G+L +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR--MLLPSGSLFFLRIVHGR 97
Query: 2409 -QRSDSGNYTCLVRNSAGED-RKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466
R D G Y C+ RN GE + V + NP+ + + A G +++C
Sbjct: 98 KSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-----MVAVGEPAVMEC 152
Query: 2467 KA-EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG 2525
+ G P P + W P RIT+ G G L I RKSD+ + VC+ N G
Sbjct: 153 QPPRGHPEPTISWKKDGS---PLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVG 208
Query: 2526 EARL-ILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
E + +LTVLE +P F S + + C A G P P++ W +G
Sbjct: 209 ERESEVAELTVLE---RPSFVKRPSN-LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
Query: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYH 2644
+S R+ + D L I +++ D G+Y CVA N G E +L V P +
Sbjct: 265 KS-----RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
Query: 2645 NLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHL----EGPQTLGRVSLLDNGTLTVRE 2700
+ V + G T+ C G Q W +L + PQ+ R S+ G LT+
Sbjct: 320 DQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 378
Query: 2701 ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGN-------TVKL 2753
D G Y+C+ G +T + V I P PVI P N T L
Sbjct: 379 VQRSDVGYYICQTLNVAGSIITKAYLEVTDV---IADRPPPVIRQGPVNQTVAVDGTFVL 435
Query: 2754 NCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQ-GSLTIQHATQRDAGFYKCMA 2812
+C+A G P I W K GV +R + G L I++A D G Y C+A
Sbjct: 436 SCVATGSPVPTILWR-------KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 488
Query: 2813 KNILGSDSKTTYIHV 2827
G + + YI V
Sbjct: 489 STPSGEATWSAYIEV 503
Score = 130 bits (328), Expect = 1e-29
Identities = 141/540 (26%), Positives = 217/540 (40%), Gaps = 54/540 (10%)
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P +EH +D V G ++C A G P P I W G V ++D R+ R
Sbjct: 29 PRIVEHP--SDLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERV----ETDKDDPRSHR- 80
Query: 2302 VVFNNGTLYFNEV-----GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAV 2356
++ +G+L+F + +EG Y C A N +G+ V + V
Sbjct: 81 MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 140
Query: 2357 QVPYGDVVTVACEA-KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
V G+ + C+ +G P P ++W + E+ I + G L+I ++SD+G
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITI-RGGKLMITYTRKSDAGK 198
Query: 2416 YTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPR 2475
Y C+ N GE V ++ P P+ + + +A C+A G P P
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE-----FKCEARGDPVPT 253
Query: 2476 VLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535
V W +G LP +R + + +L IR + D C+A N G+A LTV
Sbjct: 254 VRWRKDDGE-LPK----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 2536 LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL----QSGQQLQ 2591
EP P F +++ A+ G T++ C A G P P++ W +L Q Q
Sbjct: 309 QEP---PHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 364
Query: 2592 RFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV-----GLKPEANKQYHNL 2646
RF G L I+ + D G Y C N AG L+V P +Q
Sbjct: 365 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 424
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDR 2706
++ T L C G+ W +G+ + + R+ L+NG L +R A + D
Sbjct: 425 QTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVSTQDS--RIKQLENGVLQIRYAKLGDT 481
Query: 2707 GTYVCRMETEYGPSVTSIPVIVIAY-----PPR------ITSEPT-PVIYTRPGNTVKLN 2754
G Y C T G + S + V + PPR I S P+ P + NTV L+
Sbjct: 482 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 541
Score = 130 bits (328), Expect = 1e-29
Identities = 112/456 (24%), Positives = 185/456 (40%), Gaps = 35/456 (7%)
Query: 1858 KSPQTVSVTAETDTVFPCEAT-GKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIR 1916
++P V V V C+ G P+P ++W K + L + RI ++ G L+I
Sbjct: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS-PLDDKDERI----TIRGGKLMIT 189
Query: 1917 KVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKG 1976
+ D G+Y+C +N+ G +R + +TV + ++ V + D+ +C A+G
Sbjct: 190 YTRKSDAGKYVCVGTNMVG-ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARG 248
Query: 1977 TPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSL 2036
P P + W D + + R + ++ TL I++ + D G Y CVA N G
Sbjct: 249 DPVPTVRWRKDDGEL------PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA 302
Query: 2037 AIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQ-----IRP 2091
+ L V P + + + + ++L G ++ C A P P++ W +G+Q +P
Sbjct: 303 SATLTVQEPPHFVVKPRDQVVAL--GRTVTFQCEATGNPQPAIFW-RREGSQNLLFSYQP 359
Query: 2092 SQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAAN--ARIT 2149
Q V G L I N+ D G Y C N+ GS L V A+ +
Sbjct: 360 PQ-SSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI 418
Query: 2150 GTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVK 2209
P V GT L C A+G P P ILWR + + DSRIK NG L ++
Sbjct: 419 RQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV----LVSTQDSRIKQLENGVLQIR 474
Query: 2210 SVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATG 2269
D G Y C+A G+ ++V ++ D + K +
Sbjct: 475 YAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS 534
Query: 2270 LPNPEISW-------SLPDGSLVNSFMQSDDSGGRT 2298
+SW + P ++ +F + S +T
Sbjct: 535 RNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQT 570
Score = 118 bits (296), Expect = 7e-26
Identities = 95/315 (30%), Positives = 136/315 (43%), Gaps = 26/315 (8%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
E+P + K P ++VT + F CEA G P P V W K G L R+E+ +
Sbjct: 221 ERPSFV-KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK-DDGELPK-----SRYEIRDD 273
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAM 1970
TL IRKV D G Y C A N+ G + ++TVQ+P +D V LG T+
Sbjct: 274 HTLKIRKVTAGDMGSYTCVAENMVG--KAEASATLTVQEPPHFVVKPRDQVVALGRTVTF 331
Query: 1971 ECLAKGTPAPQISWIFP-DRRVWQTVSPVE--GRITLHENRTLSIKEASFSDRGVYKCVA 2027
+C A G P P I W + + + P + R ++ + L+I SD G Y C
Sbjct: 332 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 391
Query: 2028 SNAAGADSLAIRLHVAAL-----PPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWV 2082
N AG+ L V + PPVI Q + G + + C A +P+P++ W
Sbjct: 392 LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV-LSCVATGSPVPTILW- 449
Query: 2083 LGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRA 2142
DG + + NG L IR D+GRY C+A+ G A + + VQ
Sbjct: 450 RKDGVLVSTQD---SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEF 506
Query: 2143 AANARITGTSPRRTD 2157
+ PR TD
Sbjct: 507 GVPVQ----PPRPTD 517
Score = 105 bits (261), Expect = 8e-22
Identities = 109/409 (26%), Positives = 165/409 (40%), Gaps = 50/409 (12%)
Query: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEG--------------V 2484
PP+I +P+ + I + G ++CKAEG PTP + W + G +
Sbjct: 28 PPRIVEHPSDL-----IVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRM 81
Query: 2485 VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF 2544
+LP+ VHG S + D VC+ARN GEA ++ +E I
Sbjct: 82 LLPSGSLFFLRIVHGRKS-------RPDEGVYVCVARNYLGEA-----VSHNASLEVAIL 129
Query: 2545 HDPISEK---ITAMAGHTISLNCSAA-GTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM 2600
D + + G + C G P P++ W +G+ L + G
Sbjct: 130 RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITI---RGGK 185
Query: 2601 LHISGLSSVDAGAYRCVARNAAGHTERLVS-LKVGLKPEANKQYHNLVSIINGETLKLPC 2659
L I+ DAG Y CV N G E V+ L V +P K+ NL ++ ++ + C
Sbjct: 186 LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD-DSAEFKC 244
Query: 2660 TPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGP 2719
G W +G E P++ R + D+ TL +R+ + D G+Y C E G
Sbjct: 245 EARGDPVPTVRWRKDDG---ELPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 299
Query: 2720 SVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGV 2779
+ S + + PP +P + G TV C A G P+ I W +L
Sbjct: 300 AEASA-TLTVQEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357
Query: 2780 QARLYGNRFLHPQ-GSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
Q +RF Q G LTI + + D G+Y C N+ GS Y+ V
Sbjct: 358 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 406
Score = 53.5 bits (127), Expect = 3e-06
Identities = 55/214 (25%), Positives = 78/214 (36%), Gaps = 31/214 (14%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDS--KFSILSSGWLRIKS 544
RDQ V G C + P+IFW L P S +FS+ +G L I +
Sbjct: 319 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 378
Query: 545 MEPSDSGLYQC-------------IAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP 591
++ SD G Y C +V D + V+ Q P Q D +
Sbjct: 379 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV---- 434
Query: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLANT--SHVYMLPNGTLSIPKVQVSDSGYY 649
L C A P + W R L +T S + L NG L I ++ D+G Y
Sbjct: 435 -----LSCVATGSPVPTILW-----RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 484
Query: 650 RCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRP 683
C+A G ++ I V + G + R P
Sbjct: 485 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDP 518
Score = 50.4 bits (119), Expect = 2e-05
Identities = 51/184 (27%), Positives = 73/184 (39%), Gaps = 17/184 (9%)
Query: 488 DQTVLEGGPCQLSCNV-KASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
D V G P + C + P+I W DGS P+DD D + +I G L I
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWK-KDGS----PLDDKDERITI-RGGKLMITYTR 192
Query: 547 PSDSGLYQCIA--QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
SD+G Y C+ V + + +++ PS K + +S C A
Sbjct: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGD 249
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
P + W R+ +L S + + TL I KV D G Y CVA N G +
Sbjct: 250 PVPTVRW----RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304
Query: 665 GITV 668
+TV
Sbjct: 305 TLTV 308
Score = 47.0 bits (110), Expect = 3e-04
Identities = 53/198 (26%), Positives = 81/198 (40%), Gaps = 22/198 (11%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG---WLRIKS 544
D V +G P L+C + +P+I W G ++ DDP S +L SG +LRI
Sbjct: 37 DLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
Query: 545 MEPS--DSGLYQCIAQVRDEMDRMV-----YRVLVQSPSTQPAEKDTVTIGKNPGESVTL 597
S D G+Y C+A R+ + V V + + D + GE +
Sbjct: 96 GRKSRPDEGVYVCVA--RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA---VGEPAVM 150
Query: 598 PCN-ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
C PE +SW ++ + L + + G L I + SD+G Y CV N
Sbjct: 151 ECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 657 QGADHFTVG-ITVTKKGS 673
G V +TV ++ S
Sbjct: 207 VGERESEVAELTVLERPS 224
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 168 bits (426), Expect = 6e-41
Identities = 157/575 (27%), Positives = 240/575 (41%), Gaps = 76/575 (13%)
Query: 2039 RLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGN 2098
RL PP I E ++ + G ++C A+ P P++ W G +
Sbjct: 60 RLRQEDFPPRI-VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH 118
Query: 2099 LFVFPNGTLYIRNL-----APKDSGRYECVAANLVGSARRTVQLNVQRAAANARIT-GTS 2152
+ P+G+L+ + + D G Y CVA N +G A V N A R +
Sbjct: 119 RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEA---VSHNASLEVAILRDDFRQN 175
Query: 2153 PRRTDVRYGGTLKLDCSAS-GDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSV 2211
P V G ++C G P P I W+ + D D RI + G L++
Sbjct: 176 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK----DERITI-RGGKLMITYT 230
Query: 2212 TDKDAGDYLCVARNKVGD-DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGL 2270
DAG Y+CV N VG+ + V ++ V+ +P+ + K ++ V + C A G
Sbjct: 231 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGD 288
Query: 2271 PNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQV 2330
P P + W DG L S RY + ++ TL +V + G YTC AEN V
Sbjct: 289 PVPTVRWRKDDGELPKS------------RYEIRDDHTLKIRKVTAGDMGSYTCVAENMV 336
Query: 2331 GKDEMRVRVKVVTAPATIRNKTYLAVQ-----VPYGDVVTVACEAKGEPMPKVTWLSPTN 2385
GK E +A T++ + V+ V G VT CEA G P P + W +
Sbjct: 337 GKAE-------ASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS 389
Query: 2386 KVI------PTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHV---- 2435
+ + P SS ++ + Q G L I QRSD G Y C N AG ++ V
Sbjct: 390 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 449
Query: 2436 -NVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNR 2494
+ PP I P V + A ++ C A G P P +LW +GV++ +R
Sbjct: 450 ADRPPPVIRQGP-----VNQTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVST--QDSR 501
Query: 2495 ITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLE---PMEKP-------IF 2544
I NG L IR + D+ + C+A GEA + V E P++ P I
Sbjct: 502 IKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP 561
Query: 2545 HDPISEKITAMAGHTISL----NCSAAGTPTPSLV 2575
P ++T ++ +T++L N ++ TPT ++
Sbjct: 562 SAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII 596
Score = 154 bits (390), Expect = 9e-37
Identities = 138/511 (27%), Positives = 209/511 (40%), Gaps = 57/511 (11%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P + + P + V+ C+A G+P P + W K + +L +G+
Sbjct: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
Query: 1913 LVIRKV-----QVQDRGQYMCTASNL------HGLDRMVVLLSVTVQQPQILASHYQDVT 1961
L ++ D G Y+C A N H V +L +Q + DV
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ------NPSDVM 180
Query: 1962 VYLGDTIAMECL-AKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDR 2020
V +G+ MEC +G P P ISW ++ + + RIT+ + L I SD
Sbjct: 181 VAVGEPAVMECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGK-LMITYTRKSDA 235
Query: 2021 GVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
G Y CV +N G +S L V P + ++ N+++ S C A+ P+P+V
Sbjct: 236 GKYVCVGTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTV 293
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
RW DG ++ S++ + + TL IR + D G Y CVA N+VG A + L V
Sbjct: 294 RWRKDDG-ELPKSRY-----EIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 347
Query: 2140 QRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSF----- 2194
Q PR V G T+ C A+G+P P I WR + + LFS+
Sbjct: 348 QEPPHFV----VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ--NLLFSYQPPQS 401
Query: 2195 DSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD----DYVVLKVDVVMKPAKIEHKEE 2250
SR V G L + +V D G Y+C N G Y+ + + +P + +
Sbjct: 402 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 461
Query: 2251 NDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLY 2310
+ V G + CVATG P P I W DG LV++ + R NG L
Sbjct: 462 VNQTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQ 511
Query: 2311 FNEVGMREEGDYTCFAENQVGKDEMRVRVKV 2341
+ + G YTC A G+ ++V
Sbjct: 512 IRYAKLGDTGRYTCIASTPSGEATWSAYIEV 542
Score = 141 bits (356), Expect = 8e-33
Identities = 134/509 (26%), Positives = 199/509 (39%), Gaps = 39/509 (7%)
Query: 1950 PQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV-WQTVSPVEGRITLHENR 2008
P + H D+ V G+ + C A+G P P I W RV P R+ L
Sbjct: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
Query: 2009 TLSIK----EASFSDRGVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGL 2063
++ S D GVY CVA N G A S L VA L Q ++ + G
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP-SDVMVAVGE 185
Query: 2064 SIHIHC-TAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYEC 2122
+ C + P P++ W DG+ + G L I D+G+Y C
Sbjct: 186 PAVMECQPPRGHPEPTISW-KKDGSPLDDKD----ERITIRGGKLMITYTRKSDAGKYVC 240
Query: 2123 VAANLVGSARRTV-QLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR 2181
V N+VG V +L V + + P V + + C A GDP P + WR
Sbjct: 241 VGTNMVGERESEVAELTVLERPSFVK----RPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
Query: 2182 LPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMK 2241
+ SR ++ + TL ++ VT D G Y CVA N VG + V
Sbjct: 297 KDDGELP------KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 350
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P + + D V G + C ATG P P I W +GS + + S + R+
Sbjct: 351 PHFV--VKPRDQVVALGRTVTFQCEATGNPQPAIFWR-REGS--QNLLFSYQPPQSSSRF 405
Query: 2302 VVFNNGTLYFNEVGMREEGDYTCFAENQVG----KDEMRVRVKVVTAPATIRNKTYLAVQ 2357
V G L V + G Y C N G K + V + P + + +
Sbjct: 406 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 465
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYT 2417
V ++C A G P+P + W ++ T + + ++G L I+ A+ D+G YT
Sbjct: 466 VAVDGTFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 524
Query: 2418 CLVRNSAGEDRKTVWIHVN-----VQPPK 2441
C+ +GE + +I V VQPP+
Sbjct: 525 CIASTPSGEATWSAYIEVQEFGVPVQPPR 553
Score = 135 bits (339), Expect = 7e-31
Identities = 137/495 (27%), Positives = 199/495 (40%), Gaps = 56/495 (11%)
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLS-----PTNKVIPTSSEKYQIYQDGTLLIQKA---- 2408
V G+ T+ C+A+G P P + W T+K P S + G+L +
Sbjct: 79 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR--MLLPSGSLFFLRIVHGR 136
Query: 2409 -QRSDSGNYTCLVRNSAGED-RKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466
R D G Y C+ RN GE + V + NP+ + + A G +++C
Sbjct: 137 KSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-----MVAVGEPAVMEC 191
Query: 2467 KA-EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG 2525
+ G P P + W P RIT+ G G L I RKSD+ + VC+ N G
Sbjct: 192 QPPRGHPEPTISWKKDGS---PLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVG 247
Query: 2526 EARL-ILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
E + +LTVLE +P F S + + C A G P P++ W +G
Sbjct: 248 ERESEVAELTVLE---RPSFVKRPSN-LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 303
Query: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYH 2644
+S R+ + D L I +++ D G+Y CVA N G E +L V P +
Sbjct: 304 KS-----RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 358
Query: 2645 NLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHL----EGPQTLGRVSLLDNGTLTVRE 2700
+ V + G T+ C G Q W +L + PQ+ R S+ G LT+
Sbjct: 359 DQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 417
Query: 2701 ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGN-------TVKL 2753
D G Y+C+ G +T + V I P PVI P N T L
Sbjct: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDV---IADRPPPVIRQGPVNQTVAVDGTFVL 474
Query: 2754 NCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQ-GSLTIQHATQRDAGFYKCMA 2812
+C+A G P I W K GV +R + G L I++A D G Y C+A
Sbjct: 475 SCVATGSPVPTILWR-------KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 527
Query: 2813 KNILGSDSKTTYIHV 2827
G + + YI V
Sbjct: 528 STPSGEATWSAYIEV 542
Score = 130 bits (328), Expect = 1e-29
Identities = 141/540 (26%), Positives = 217/540 (40%), Gaps = 54/540 (10%)
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P +EH +D V G ++C A G P P I W G V ++D R+ R
Sbjct: 68 PRIVEHP--SDLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERV----ETDKDDPRSHR- 119
Query: 2302 VVFNNGTLYFNEV-----GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAV 2356
++ +G+L+F + +EG Y C A N +G+ V + V
Sbjct: 120 MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 179
Query: 2357 QVPYGDVVTVACEA-KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
V G+ + C+ +G P P ++W + E+ I + G L+I ++SD+G
Sbjct: 180 MVAVGEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITI-RGGKLMITYTRKSDAGK 237
Query: 2416 YTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPR 2475
Y C+ N GE V ++ P P+ + + +A C+A G P P
Sbjct: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE-----FKCEARGDPVPT 292
Query: 2476 VLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535
V W +G LP +R + + +L IR + D C+A N G+A LTV
Sbjct: 293 VRWRKDDGE-LPK----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 347
Query: 2536 LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL----QSGQQLQ 2591
EP P F +++ A+ G T++ C A G P P++ W +L Q Q
Sbjct: 348 QEP---PHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 403
Query: 2592 RFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV-----GLKPEANKQYHNL 2646
RF G L I+ + D G Y C N AG L+V P +Q
Sbjct: 404 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 463
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDR 2706
++ T L C G+ W +G+ + + R+ L+NG L +R A + D
Sbjct: 464 QTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVSTQDS--RIKQLENGVLQIRYAKLGDT 520
Query: 2707 GTYVCRMETEYGPSVTSIPVIVIAY-----PPR------ITSEPT-PVIYTRPGNTVKLN 2754
G Y C T G + S + V + PPR I S P+ P + NTV L+
Sbjct: 521 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 580
Score = 130 bits (328), Expect = 1e-29
Identities = 112/456 (24%), Positives = 185/456 (40%), Gaps = 35/456 (7%)
Query: 1858 KSPQTVSVTAETDTVFPCEAT-GKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIR 1916
++P V V V C+ G P+P ++W K + L + RI ++ G L+I
Sbjct: 174 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS-PLDDKDERI----TIRGGKLMIT 228
Query: 1917 KVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKG 1976
+ D G+Y+C +N+ G +R + +TV + ++ V + D+ +C A+G
Sbjct: 229 YTRKSDAGKYVCVGTNMVG-ERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARG 287
Query: 1977 TPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSL 2036
P P + W D + + R + ++ TL I++ + D G Y CVA N G
Sbjct: 288 DPVPTVRWRKDDGEL------PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA 341
Query: 2037 AIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQ-----IRP 2091
+ L V P + + + + ++L G ++ C A P P++ W +G+Q +P
Sbjct: 342 SATLTVQEPPHFVVKPRDQVVAL--GRTVTFQCEATGNPQPAIFW-RREGSQNLLFSYQP 398
Query: 2092 SQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAAN--ARIT 2149
Q V G L I N+ D G Y C N+ GS L V A+ +
Sbjct: 399 PQ-SSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI 457
Query: 2150 GTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVK 2209
P V GT L C A+G P P ILWR + + DSRIK NG L ++
Sbjct: 458 RQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV----LVSTQDSRIKQLENGVLQIR 513
Query: 2210 SVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATG 2269
D G Y C+A G+ ++V ++ D + K +
Sbjct: 514 YAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS 573
Query: 2270 LPNPEISW-------SLPDGSLVNSFMQSDDSGGRT 2298
+SW + P ++ +F + S +T
Sbjct: 574 RNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQT 609
Score = 118 bits (296), Expect = 7e-26
Identities = 95/315 (30%), Positives = 136/315 (43%), Gaps = 26/315 (8%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
E+P + K P ++VT + F CEA G P P V W K G L R+E+ +
Sbjct: 260 ERPSFV-KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK-DDGELPK-----SRYEIRDD 312
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAM 1970
TL IRKV D G Y C A N+ G + ++TVQ+P +D V LG T+
Sbjct: 313 HTLKIRKVTAGDMGSYTCVAENMVG--KAEASATLTVQEPPHFVVKPRDQVVALGRTVTF 370
Query: 1971 ECLAKGTPAPQISWIFP-DRRVWQTVSPVE--GRITLHENRTLSIKEASFSDRGVYKCVA 2027
+C A G P P I W + + + P + R ++ + L+I SD G Y C
Sbjct: 371 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 430
Query: 2028 SNAAGADSLAIRLHVAAL-----PPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWV 2082
N AG+ L V + PPVI Q + G + + C A +P+P++ W
Sbjct: 431 LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV-LSCVATGSPVPTILW- 488
Query: 2083 LGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRA 2142
DG + + NG L IR D+GRY C+A+ G A + + VQ
Sbjct: 489 RKDGVLVSTQD---SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEF 545
Query: 2143 AANARITGTSPRRTD 2157
+ PR TD
Sbjct: 546 GVPVQ----PPRPTD 556
Score = 105 bits (261), Expect = 8e-22
Identities = 109/409 (26%), Positives = 165/409 (40%), Gaps = 50/409 (12%)
Query: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEG--------------V 2484
PP+I +P+ + I + G ++CKAEG PTP + W + G +
Sbjct: 67 PPRIVEHPSDL-----IVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRM 120
Query: 2485 VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF 2544
+LP+ VHG S + D VC+ARN GEA ++ +E I
Sbjct: 121 LLPSGSLFFLRIVHGRKS-------RPDEGVYVCVARNYLGEA-----VSHNASLEVAIL 168
Query: 2545 HDPISEK---ITAMAGHTISLNCSAA-GTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM 2600
D + + G + C G P P++ W +G+ L + G
Sbjct: 169 RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITI---RGGK 224
Query: 2601 LHISGLSSVDAGAYRCVARNAAGHTERLVS-LKVGLKPEANKQYHNLVSIINGETLKLPC 2659
L I+ DAG Y CV N G E V+ L V +P K+ NL ++ ++ + C
Sbjct: 225 LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD-DSAEFKC 283
Query: 2660 TPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGP 2719
G W +G E P++ R + D+ TL +R+ + D G+Y C E G
Sbjct: 284 EARGDPVPTVRWRKDDG---ELPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 338
Query: 2720 SVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGV 2779
+ S + + PP +P + G TV C A G P+ I W +L
Sbjct: 339 AEASA-TLTVQEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 396
Query: 2780 QARLYGNRFLHPQ-GSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
Q +RF Q G LTI + + D G+Y C N+ GS Y+ V
Sbjct: 397 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 445
Score = 53.5 bits (127), Expect = 3e-06
Identities = 55/214 (25%), Positives = 78/214 (36%), Gaps = 31/214 (14%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDS--KFSILSSGWLRIKS 544
RDQ V G C + P+IFW L P S +FS+ +G L I +
Sbjct: 358 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 417
Query: 545 MEPSDSGLYQC-------------IAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP 591
++ SD G Y C +V D + V+ Q P Q D +
Sbjct: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV---- 473
Query: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLANT--SHVYMLPNGTLSIPKVQVSDSGYY 649
L C A P + W R L +T S + L NG L I ++ D+G Y
Sbjct: 474 -----LSCVATGSPVPTILW-----RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 523
Query: 650 RCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRP 683
C+A G ++ I V + G + R P
Sbjct: 524 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDP 557
Score = 50.4 bits (119), Expect = 2e-05
Identities = 51/184 (27%), Positives = 73/184 (39%), Gaps = 17/184 (9%)
Query: 488 DQTVLEGGPCQLSCNV-KASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
D V G P + C + P+I W DGS P+DD D + +I G L I
Sbjct: 178 DVMVAVGEPAVMECQPPRGHPEPTISWK-KDGS----PLDDKDERITI-RGGKLMITYTR 231
Query: 547 PSDSGLYQCIA--QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
SD+G Y C+ V + + +++ PS K + +S C A
Sbjct: 232 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGD 288
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
P + W R+ +L S + + TL I KV D G Y CVA N G +
Sbjct: 289 PVPTVRW----RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 343
Query: 665 GITV 668
+TV
Sbjct: 344 TLTV 347
Score = 47.0 bits (110), Expect = 3e-04
Identities = 53/198 (26%), Positives = 81/198 (40%), Gaps = 22/198 (11%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG---WLRIKS 544
D V +G P L+C + +P+I W G ++ DDP S +L SG +LRI
Sbjct: 76 DLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 134
Query: 545 MEPS--DSGLYQCIAQVRDEMDRMV-----YRVLVQSPSTQPAEKDTVTIGKNPGESVTL 597
S D G+Y C+A R+ + V V + + D + GE +
Sbjct: 135 GRKSRPDEGVYVCVA--RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA---VGEPAVM 189
Query: 598 PCN-ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
C PE +SW ++ + L + + G L I + SD+G Y CV N
Sbjct: 190 ECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 245
Query: 657 QGADHFTVG-ITVTKKGS 673
G V +TV ++ S
Sbjct: 246 VGERESEVAELTVLERPS 263
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 156 bits (394), Expect = 3e-37
Identities = 138/511 (27%), Positives = 210/511 (41%), Gaps = 54/511 (10%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P + + P + V+ C+A G+P P + W K + +L +G+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 1913 LVIRKV-----QVQDRGQYMCTASNL------HGLDRMVVLLSVTVQQPQILASHYQDVT 1961
L ++ D G Y+C A N H V +L +Q + DV
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ------NPSDVM 141
Query: 1962 VYLGDTIAMECLA-KGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDR 2020
V +G+ MEC +G P P ISW ++ + + RIT+ + L I SD
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGK-LMITYTRKSDA 196
Query: 2021 GVYKCVASNAAGA-DSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
G Y CV +N G +S L V P + ++ N+++ S C A+ P+P+V
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTV 254
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
RW DG ++ S++ + + TL IR + D G Y CVA N+VG A + L V
Sbjct: 255 RWRKDDG-ELPKSRYE-----IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 2140 QRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSF----- 2194
Q + PR V G T+ C A+G+P P I WR + + LFS+
Sbjct: 309 QVGSEPPHFV-VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ--NLLFSYQPPQS 365
Query: 2195 DSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD----DYVVLKVDVVMKPAKIEHKEE 2250
SR V G L + +V D G Y+C N G Y+ + + +P + +
Sbjct: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 425
Query: 2251 NDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLY 2310
+ V G + CVATG P P I W DG LV++ + R NG L
Sbjct: 426 VNQTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQ 475
Query: 2311 FNEVGMREEGDYTCFAENQVGKDEMRVRVKV 2341
+ + G YTC A G+ ++V
Sbjct: 476 IRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Score = 148 bits (374), Expect = 7e-35
Identities = 134/490 (27%), Positives = 201/490 (41%), Gaps = 57/490 (11%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTD---- 2213
V G L+C A G P P I W +R+ S + +G+L +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 2214 -KDAGDYLCVARNKVGD--------DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVD 2264
D G Y+CVARN +G+ + +L+ D P+ D V G ++
Sbjct: 100 RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS--------DVMVAVGEPAVME 151
Query: 2265 CVAT-GLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYT 2323
C G P P ISW DGS + DD R + G L + G Y
Sbjct: 152 CQPPRGHPEPTISWK-KDGSPL------DDKDER----ITIRGGKLMITYTRKSDAGKYV 200
Query: 2324 CFAENQVGKDEMRV-RVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLS 2382
C N VG+ E V + V+ P+ ++ + LAV V D CEA+G+P+P V W
Sbjct: 201 CVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRK 258
Query: 2383 PTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAG--EDRKTVWIHVNVQPP 2440
+ +P S +Y+I D TL I+K D G+YTC+ N G E T+ + V +PP
Sbjct: 259 DDGE-LPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 2441 KINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVL----PAPYYGNRIT 2496
P ++ A G C+A G P P + W L P +R +
Sbjct: 316 HFVVKPRD-----QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 2497 VHGNGSLDIRSLRKSDSVQLVCMARNEGGE--ARLILQLT-VLEPMEKPIFHDPISEKIT 2553
V G L I ++++SD +C N G + L++T V+ P+ +
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 2554 AMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGA 2613
A+ G T L+C A G+P P+++W + Q R +G+L I D G
Sbjct: 431 AVDG-TFVLSCVATGSPVPTILW---RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGR 486
Query: 2614 YRCVARNAAG 2623
Y C+A +G
Sbjct: 487 YTCIASTPSG 496
Score = 143 bits (361), Expect = 2e-33
Identities = 137/512 (26%), Positives = 200/512 (39%), Gaps = 42/512 (8%)
Query: 1950 PQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV-WQTVSPVEGRITLHENR 2008
P + H D+ V G+ + C A+G P P I W RV P R+ L
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 2009 TLSIK----EASFSDRGVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGL 2063
++ S D GVY CVA N G A S L VA L Q ++ + G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP-SDVMVAVGE 146
Query: 2064 SIHIHCTA-KAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYEC 2122
+ C + P P++ W DG+ + G L I D+G+Y C
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDKD----ERITIRGGKLMITYTRKSDAGKYVC 201
Query: 2123 VAANLVGSARRTV-QLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR 2181
V N+VG V +L V + + P V + + C A GDP P + WR
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVK----RPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 2182 LPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG--DDYVVLKVDVV 2239
+ SR ++ + TL ++ VT D G Y CVA N VG + L V V
Sbjct: 258 KDDGELPK------SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVG 311
Query: 2240 MKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDG-SLVNSFMQSDDSGGRT 2298
+P K D V G + C ATG P P I W +L+ S+ S
Sbjct: 312 SEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS--- 367
Query: 2299 KRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG----KDEMRVRVKVVTAPATIRNKTYL 2354
R+ V G L V + G Y C N G K + V + P + + +
Sbjct: 368 -RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 426
Query: 2355 AVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSG 2414
V ++C A G P+P + W ++ T + + ++G L I+ A+ D+G
Sbjct: 427 NQTVAVDGTFVLSCVATGSPVPTILWRKD-GVLVSTQDSRIKQLENGVLQIRYAKLGDTG 485
Query: 2415 NYTCLVRNSAGEDRKTVWIHVN-----VQPPK 2441
YTC+ +GE + +I V VQPP+
Sbjct: 486 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 517
Score = 134 bits (337), Expect = 1e-30
Identities = 139/499 (27%), Positives = 203/499 (40%), Gaps = 61/499 (12%)
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLS-----PTNKVIPTSSEKYQIYQDGTLLIQKA---- 2408
V G+ T+ C+A+G P P + W T+K P S + G+L +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR--MLLPSGSLFFLRIVHGR 97
Query: 2409 -QRSDSGNYTCLVRNSAGED-RKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466
R D G Y C+ RN GE + V + NP+ + + A G +++C
Sbjct: 98 KSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-----MVAVGEPAVMEC 152
Query: 2467 KA-EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG 2525
+ G P P + W P RIT+ G G L I RKSD+ + VC+ N G
Sbjct: 153 QPPRGHPEPTISWKKDGS---PLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVG 208
Query: 2526 EARL-ILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
E + +LTVLE +P F S + + C A G P P++ W +G
Sbjct: 209 ERESEVAELTVLE---RPSFVKRPSN-LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
Query: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSL--KVGLKPE--AN 2640
+S R+ + D L I +++ D G+Y CVA N G E +L +VG +P
Sbjct: 265 KS-----RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 2641 KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHL----EGPQTLGRVSLLDNGTL 2696
K +V++ G T+ C G Q W +L + PQ+ R S+ G L
Sbjct: 320 KPRDQVVAL--GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 2697 TVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGN------- 2749
T+ D G Y+C+ G +T + V I P PVI P N
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV---IADRPPPVIRQGPVNQTVAVDG 434
Query: 2750 TVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQ-GSLTIQHATQRDAGFY 2808
T L+C+A G P I W K GV +R + G L I++A D G Y
Sbjct: 435 TFVLSCVATGSPVPTILWR-------KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
Query: 2809 KCMAKNILGSDSKTTYIHV 2827
C+A G + + YI V
Sbjct: 488 TCIASTPSGEATWSAYIEV 506
Score = 131 bits (329), Expect = 1e-29
Identities = 140/540 (25%), Positives = 216/540 (40%), Gaps = 51/540 (9%)
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P +EH +D V G ++C A G P P I W G V ++D R+ R
Sbjct: 29 PRIVEHP--SDLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERV----ETDKDDPRSHR- 80
Query: 2302 VVFNNGTLYFNEV-----GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAV 2356
++ +G+L+F + +EG Y C A N +G+ V + V
Sbjct: 81 MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 140
Query: 2357 QVPYGDVVTVACEA-KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
V G+ + C+ +G P P ++W + E+ I + G L+I ++SD+G
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITI-RGGKLMITYTRKSDAGK 198
Query: 2416 YTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPR 2475
Y C+ N GE V ++ P P+ + + +A C+A G P P
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE-----FKCEARGDPVPT 253
Query: 2476 VLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535
V W +G LP +R + + +L IR + D C+A N G+A LTV
Sbjct: 254 VRWRKDDGE-LPK----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 2536 LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL----QSGQQLQ 2591
E P F +++ A+ G T++ C A G P P++ W +L Q Q
Sbjct: 309 QVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 367
Query: 2592 RFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV-----GLKPEANKQYHNL 2646
RF G L I+ + D G Y C N AG L+V P +Q
Sbjct: 368 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 427
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDR 2706
++ T L C G+ W +G+ + + R+ L+NG L +R A + D
Sbjct: 428 QTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVSTQDS--RIKQLENGVLQIRYAKLGDT 484
Query: 2707 GTYVCRMETEYGPSVTSIPVIVIAY-----PPR------ITSEPT-PVIYTRPGNTVKLN 2754
G Y C T G + S + V + PPR I S P+ P + NTV L+
Sbjct: 485 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 544
Score = 104 bits (260), Expect = 1e-21
Identities = 111/411 (27%), Positives = 167/411 (40%), Gaps = 51/411 (12%)
Query: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEG--------------V 2484
PP+I +P+ + I + G ++CKAEG PTP + W + G +
Sbjct: 28 PPRIVEHPSDL-----IVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRM 81
Query: 2485 VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF 2544
+LP+ VHG S + D VC+ARN GEA ++ +E I
Sbjct: 82 LLPSGSLFFLRIVHGRKS-------RPDEGVYVCVARNYLGEA-----VSHNASLEVAIL 129
Query: 2545 HDPISEK---ITAMAGHTISLNCSAA-GTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM 2600
D + + G + C G P P++ W +G+ L + G
Sbjct: 130 RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITI---RGGK 185
Query: 2601 LHISGLSSVDAGAYRCVARNAAGHTERLVS-LKVGLKPEANKQYHNLVSIINGETLKLPC 2659
L I+ DAG Y CV N G E V+ L V +P K+ NL ++ ++ + C
Sbjct: 186 LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD-DSAEFKC 244
Query: 2660 TPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGP 2719
G W +G E P++ R + D+ TL +R+ + D G+Y C E G
Sbjct: 245 EARGDPVPTVRWRKDDG---ELPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 299
Query: 2720 SVTS--IPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKA 2777
+ S + V V + PP +P + G TV C A G P+ I W +L
Sbjct: 300 AEASATLTVQVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLF 358
Query: 2778 GVQARLYGNRFLHPQ-GSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
Q +RF Q G LTI + + D G+Y C N+ GS Y+ V
Sbjct: 359 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 90.1 bits (222), Expect = 3e-17
Identities = 60/191 (31%), Positives = 84/191 (43%), Gaps = 11/191 (5%)
Query: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALM---TPNTRIQRF 1905
+G +P P+ V F CEATG P+P + W + + L+ P RF
Sbjct: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 1906 EVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVT----VQQPQILASHYQDVT 1961
V + G L I VQ D G Y+C N+ G L VT + P ++ + T
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 1962 VYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRG 2021
V + T + C+A G+P P I W R+ VS + RI EN L I+ A D G
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTG 485
Query: 2022 VYKCVASNAAG 2032
Y C+AS +G
Sbjct: 486 RYTCIASTPSG 496
Score = 53.5 bits (127), Expect = 3e-06
Identities = 55/214 (25%), Positives = 78/214 (36%), Gaps = 31/214 (14%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDS--KFSILSSGWLRIKS 544
RDQ V G C + P+IFW L P S +FS+ +G L I +
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
Query: 545 MEPSDSGLYQC-------------IAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP 591
++ SD G Y C +V D + V+ Q P Q D +
Sbjct: 382 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV---- 437
Query: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLANT--SHVYMLPNGTLSIPKVQVSDSGYY 649
L C A P + W R L +T S + L NG L I ++ D+G Y
Sbjct: 438 -----LSCVATGSPVPTILW-----RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
Query: 650 RCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRP 683
C+A G ++ I V + G + R P
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDP 521
Score = 50.4 bits (119), Expect = 2e-05
Identities = 51/184 (27%), Positives = 73/184 (39%), Gaps = 17/184 (9%)
Query: 488 DQTVLEGGPCQLSCNV-KASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
D V G P + C + P+I W DGS P+DD D + +I G L I
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWK-KDGS----PLDDKDERITI-RGGKLMITYTR 192
Query: 547 PSDSGLYQCIA--QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
SD+G Y C+ V + + +++ PS K + +S C A
Sbjct: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGD 249
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
P + W R+ +L S + + TL I KV D G Y CVA N G +
Sbjct: 250 PVPTVRW----RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304
Query: 665 GITV 668
+TV
Sbjct: 305 TLTV 308
Score = 47.0 bits (110), Expect = 3e-04
Identities = 53/198 (26%), Positives = 81/198 (40%), Gaps = 22/198 (11%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG---WLRIKS 544
D V +G P L+C + +P+I W G ++ DDP S +L SG +LRI
Sbjct: 37 DLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
Query: 545 MEPS--DSGLYQCIAQVRDEMDRMV-----YRVLVQSPSTQPAEKDTVTIGKNPGESVTL 597
S D G+Y C+A R+ + V V + + D + GE +
Sbjct: 96 GRKSRPDEGVYVCVA--RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA---VGEPAVM 150
Query: 598 PCN-ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
C PE +SW ++ + L + + G L I + SD+G Y CV N
Sbjct: 151 ECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 657 QGADHFTVG-ITVTKKGS 673
G V +TV ++ S
Sbjct: 207 VGERESEVAELTVLERPS 224
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 156 bits (394), Expect = 3e-37
Identities = 138/511 (27%), Positives = 210/511 (41%), Gaps = 54/511 (10%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P + + P + V+ C+A G+P P + W K + +L +G+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 1913 LVIRKV-----QVQDRGQYMCTASNL------HGLDRMVVLLSVTVQQPQILASHYQDVT 1961
L ++ D G Y+C A N H V +L +Q + DV
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ------NPSDVM 141
Query: 1962 VYLGDTIAMECLA-KGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDR 2020
V +G+ MEC +G P P ISW ++ + + RIT+ + L I SD
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGK-LMITYTRKSDA 196
Query: 2021 GVYKCVASNAAGA-DSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
G Y CV +N G +S L V P + ++ N+++ S C A+ P+P+V
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTV 254
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
RW DG ++ S++ + + TL IR + D G Y CVA N+VG A + L V
Sbjct: 255 RWRKDDG-ELPKSRYE-----IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 2140 QRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSF----- 2194
Q + PR V G T+ C A+G+P P I WR + + LFS+
Sbjct: 309 QVGSEPPHFV-VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ--NLLFSYQPPQS 365
Query: 2195 DSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD----DYVVLKVDVVMKPAKIEHKEE 2250
SR V G L + +V D G Y+C N G Y+ + + +P + +
Sbjct: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 425
Query: 2251 NDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLY 2310
+ V G + CVATG P P I W DG LV++ + R NG L
Sbjct: 426 VNQTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQ 475
Query: 2311 FNEVGMREEGDYTCFAENQVGKDEMRVRVKV 2341
+ + G YTC A G+ ++V
Sbjct: 476 IRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Score = 148 bits (374), Expect = 7e-35
Identities = 134/490 (27%), Positives = 201/490 (41%), Gaps = 57/490 (11%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTD---- 2213
V G L+C A G P P I W +R+ S + +G+L +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 2214 -KDAGDYLCVARNKVGD--------DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVD 2264
D G Y+CVARN +G+ + +L+ D P+ D V G ++
Sbjct: 100 RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS--------DVMVAVGEPAVME 151
Query: 2265 CVAT-GLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYT 2323
C G P P ISW DGS + DD R + G L + G Y
Sbjct: 152 CQPPRGHPEPTISWK-KDGSPL------DDKDER----ITIRGGKLMITYTRKSDAGKYV 200
Query: 2324 CFAENQVGKDEMRV-RVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLS 2382
C N VG+ E V + V+ P+ ++ + LAV V D CEA+G+P+P V W
Sbjct: 201 CVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRK 258
Query: 2383 PTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAG--EDRKTVWIHVNVQPP 2440
+ +P S +Y+I D TL I+K D G+YTC+ N G E T+ + V +PP
Sbjct: 259 DDGE-LPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 2441 KINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVL----PAPYYGNRIT 2496
P ++ A G C+A G P P + W L P +R +
Sbjct: 316 HFVVKPRD-----QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 2497 VHGNGSLDIRSLRKSDSVQLVCMARNEGGE--ARLILQLT-VLEPMEKPIFHDPISEKIT 2553
V G L I ++++SD +C N G + L++T V+ P+ +
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 2554 AMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGA 2613
A+ G T L+C A G+P P+++W + Q R +G+L I D G
Sbjct: 431 AVDG-TFVLSCVATGSPVPTILW---RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGR 486
Query: 2614 YRCVARNAAG 2623
Y C+A +G
Sbjct: 487 YTCIASTPSG 496
Score = 143 bits (361), Expect = 2e-33
Identities = 137/512 (26%), Positives = 200/512 (39%), Gaps = 42/512 (8%)
Query: 1950 PQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV-WQTVSPVEGRITLHENR 2008
P + H D+ V G+ + C A+G P P I W RV P R+ L
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 2009 TLSIK----EASFSDRGVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGL 2063
++ S D GVY CVA N G A S L VA L Q ++ + G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP-SDVMVAVGE 146
Query: 2064 SIHIHCTA-KAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYEC 2122
+ C + P P++ W DG+ + G L I D+G+Y C
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDKD----ERITIRGGKLMITYTRKSDAGKYVC 201
Query: 2123 VAANLVGSARRTV-QLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR 2181
V N+VG V +L V + + P V + + C A GDP P + WR
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVK----RPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 2182 LPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG--DDYVVLKVDVV 2239
+ SR ++ + TL ++ VT D G Y CVA N VG + L V V
Sbjct: 258 KDDGELPK------SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVG 311
Query: 2240 MKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDG-SLVNSFMQSDDSGGRT 2298
+P K D V G + C ATG P P I W +L+ S+ S
Sbjct: 312 SEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS--- 367
Query: 2299 KRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG----KDEMRVRVKVVTAPATIRNKTYL 2354
R+ V G L V + G Y C N G K + V + P + + +
Sbjct: 368 -RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 426
Query: 2355 AVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSG 2414
V ++C A G P+P + W ++ T + + ++G L I+ A+ D+G
Sbjct: 427 NQTVAVDGTFVLSCVATGSPVPTILWRKD-GVLVSTQDSRIKQLENGVLQIRYAKLGDTG 485
Query: 2415 NYTCLVRNSAGEDRKTVWIHVN-----VQPPK 2441
YTC+ +GE + +I V VQPP+
Sbjct: 486 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 517
Score = 134 bits (337), Expect = 1e-30
Identities = 139/499 (27%), Positives = 203/499 (40%), Gaps = 61/499 (12%)
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLS-----PTNKVIPTSSEKYQIYQDGTLLIQKA---- 2408
V G+ T+ C+A+G P P + W T+K P S + G+L +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR--MLLPSGSLFFLRIVHGR 97
Query: 2409 -QRSDSGNYTCLVRNSAGED-RKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466
R D G Y C+ RN GE + V + NP+ + + A G +++C
Sbjct: 98 KSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-----MVAVGEPAVMEC 152
Query: 2467 KA-EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG 2525
+ G P P + W P RIT+ G G L I RKSD+ + VC+ N G
Sbjct: 153 QPPRGHPEPTISWKKDGS---PLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVG 208
Query: 2526 EARL-ILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
E + +LTVLE +P F S + + C A G P P++ W +G
Sbjct: 209 ERESEVAELTVLE---RPSFVKRPSN-LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
Query: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSL--KVGLKPE--AN 2640
+S R+ + D L I +++ D G+Y CVA N G E +L +VG +P
Sbjct: 265 KS-----RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 2641 KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHL----EGPQTLGRVSLLDNGTL 2696
K +V++ G T+ C G Q W +L + PQ+ R S+ G L
Sbjct: 320 KPRDQVVAL--GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 2697 TVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGN------- 2749
T+ D G Y+C+ G +T + V I P PVI P N
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV---IADRPPPVIRQGPVNQTVAVDG 434
Query: 2750 TVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQ-GSLTIQHATQRDAGFY 2808
T L+C+A G P I W K GV +R + G L I++A D G Y
Sbjct: 435 TFVLSCVATGSPVPTILWR-------KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
Query: 2809 KCMAKNILGSDSKTTYIHV 2827
C+A G + + YI V
Sbjct: 488 TCIASTPSGEATWSAYIEV 506
Score = 131 bits (329), Expect = 1e-29
Identities = 140/540 (25%), Positives = 216/540 (40%), Gaps = 51/540 (9%)
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P +EH +D V G ++C A G P P I W G V ++D R+ R
Sbjct: 29 PRIVEHP--SDLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERV----ETDKDDPRSHR- 80
Query: 2302 VVFNNGTLYFNEV-----GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAV 2356
++ +G+L+F + +EG Y C A N +G+ V + V
Sbjct: 81 MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 140
Query: 2357 QVPYGDVVTVACEA-KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
V G+ + C+ +G P P ++W + E+ I + G L+I ++SD+G
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITI-RGGKLMITYTRKSDAGK 198
Query: 2416 YTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPR 2475
Y C+ N GE V ++ P P+ + + +A C+A G P P
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE-----FKCEARGDPVPT 253
Query: 2476 VLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535
V W +G LP +R + + +L IR + D C+A N G+A LTV
Sbjct: 254 VRWRKDDGE-LPK----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 2536 LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL----QSGQQLQ 2591
E P F +++ A+ G T++ C A G P P++ W +L Q Q
Sbjct: 309 QVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 367
Query: 2592 RFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV-----GLKPEANKQYHNL 2646
RF G L I+ + D G Y C N AG L+V P +Q
Sbjct: 368 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 427
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDR 2706
++ T L C G+ W +G+ + + R+ L+NG L +R A + D
Sbjct: 428 QTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVSTQDS--RIKQLENGVLQIRYAKLGDT 484
Query: 2707 GTYVCRMETEYGPSVTSIPVIVIAY-----PPR------ITSEPT-PVIYTRPGNTVKLN 2754
G Y C T G + S + V + PPR I S P+ P + NTV L+
Sbjct: 485 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 544
Score = 104 bits (260), Expect = 1e-21
Identities = 111/411 (27%), Positives = 167/411 (40%), Gaps = 51/411 (12%)
Query: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEG--------------V 2484
PP+I +P+ + I + G ++CKAEG PTP + W + G +
Sbjct: 28 PPRIVEHPSDL-----IVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRM 81
Query: 2485 VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF 2544
+LP+ VHG S + D VC+ARN GEA ++ +E I
Sbjct: 82 LLPSGSLFFLRIVHGRKS-------RPDEGVYVCVARNYLGEA-----VSHNASLEVAIL 129
Query: 2545 HDPISEK---ITAMAGHTISLNCSAA-GTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM 2600
D + + G + C G P P++ W +G+ L + G
Sbjct: 130 RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITI---RGGK 185
Query: 2601 LHISGLSSVDAGAYRCVARNAAGHTERLVS-LKVGLKPEANKQYHNLVSIINGETLKLPC 2659
L I+ DAG Y CV N G E V+ L V +P K+ NL ++ ++ + C
Sbjct: 186 LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD-DSAEFKC 244
Query: 2660 TPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGP 2719
G W +G E P++ R + D+ TL +R+ + D G+Y C E G
Sbjct: 245 EARGDPVPTVRWRKDDG---ELPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 299
Query: 2720 SVTS--IPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKA 2777
+ S + V V + PP +P + G TV C A G P+ I W +L
Sbjct: 300 AEASATLTVQVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLF 358
Query: 2778 GVQARLYGNRFLHPQ-GSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
Q +RF Q G LTI + + D G+Y C N+ GS Y+ V
Sbjct: 359 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 90.1 bits (222), Expect = 3e-17
Identities = 60/191 (31%), Positives = 84/191 (43%), Gaps = 11/191 (5%)
Query: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALM---TPNTRIQRF 1905
+G +P P+ V F CEATG P+P + W + + L+ P RF
Sbjct: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 1906 EVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVT----VQQPQILASHYQDVT 1961
V + G L I VQ D G Y+C N+ G L VT + P ++ + T
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 1962 VYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRG 2021
V + T + C+A G+P P I W R+ VS + RI EN L I+ A D G
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTG 485
Query: 2022 VYKCVASNAAG 2032
Y C+AS +G
Sbjct: 486 RYTCIASTPSG 496
Score = 53.5 bits (127), Expect = 3e-06
Identities = 55/214 (25%), Positives = 78/214 (36%), Gaps = 31/214 (14%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDS--KFSILSSGWLRIKS 544
RDQ V G C + P+IFW L P S +FS+ +G L I +
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
Query: 545 MEPSDSGLYQC-------------IAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP 591
++ SD G Y C +V D + V+ Q P Q D +
Sbjct: 382 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV---- 437
Query: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLANT--SHVYMLPNGTLSIPKVQVSDSGYY 649
L C A P + W R L +T S + L NG L I ++ D+G Y
Sbjct: 438 -----LSCVATGSPVPTILW-----RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
Query: 650 RCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRP 683
C+A G ++ I V + G + R P
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDP 521
Score = 50.4 bits (119), Expect = 2e-05
Identities = 51/184 (27%), Positives = 73/184 (39%), Gaps = 17/184 (9%)
Query: 488 DQTVLEGGPCQLSCNV-KASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
D V G P + C + P+I W DGS P+DD D + +I G L I
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWK-KDGS----PLDDKDERITI-RGGKLMITYTR 192
Query: 547 PSDSGLYQCIA--QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
SD+G Y C+ V + + +++ PS K + +S C A
Sbjct: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGD 249
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
P + W R+ +L S + + TL I KV D G Y CVA N G +
Sbjct: 250 PVPTVRW----RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304
Query: 665 GITV 668
+TV
Sbjct: 305 TLTV 308
Score = 47.0 bits (110), Expect = 3e-04
Identities = 53/198 (26%), Positives = 81/198 (40%), Gaps = 22/198 (11%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG---WLRIKS 544
D V +G P L+C + +P+I W G ++ DDP S +L SG +LRI
Sbjct: 37 DLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
Query: 545 MEPS--DSGLYQCIAQVRDEMDRMV-----YRVLVQSPSTQPAEKDTVTIGKNPGESVTL 597
S D G+Y C+A R+ + V V + + D + GE +
Sbjct: 96 GRKSRPDEGVYVCVA--RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA---VGEPAVM 150
Query: 598 PCN-ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
C PE +SW ++ + L + + G L I + SD+G Y CV N
Sbjct: 151 ECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 657 QGADHFTVG-ITVTKKGS 673
G V +TV ++ S
Sbjct: 207 VGERESEVAELTVLERPS 224
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 156 bits (394), Expect = 3e-37
Identities = 138/511 (27%), Positives = 210/511 (41%), Gaps = 54/511 (10%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P + + P + V+ C+A G+P P + W K + +L +G+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 1913 LVIRKV-----QVQDRGQYMCTASNL------HGLDRMVVLLSVTVQQPQILASHYQDVT 1961
L ++ D G Y+C A N H V +L +Q + DV
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ------NPSDVM 141
Query: 1962 VYLGDTIAMECLA-KGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDR 2020
V +G+ MEC +G P P ISW ++ + + RIT+ + L I SD
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGK-LMITYTRKSDA 196
Query: 2021 GVYKCVASNAAGA-DSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
G Y CV +N G +S L V P + ++ N+++ S C A+ P+P+V
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTV 254
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
RW DG ++ S++ + + TL IR + D G Y CVA N+VG A + L V
Sbjct: 255 RWRKDDG-ELPKSRYE-----IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 2140 QRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSF----- 2194
Q + PR V G T+ C A+G+P P I WR + + LFS+
Sbjct: 309 QVGSEPPHFV-VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ--NLLFSYQPPQS 365
Query: 2195 DSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD----DYVVLKVDVVMKPAKIEHKEE 2250
SR V G L + +V D G Y+C N G Y+ + + +P + +
Sbjct: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 425
Query: 2251 NDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLY 2310
+ V G + CVATG P P I W DG LV++ + R NG L
Sbjct: 426 VNQTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQ 475
Query: 2311 FNEVGMREEGDYTCFAENQVGKDEMRVRVKV 2341
+ + G YTC A G+ ++V
Sbjct: 476 IRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Score = 148 bits (374), Expect = 7e-35
Identities = 134/490 (27%), Positives = 201/490 (41%), Gaps = 57/490 (11%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTD---- 2213
V G L+C A G P P I W +R+ S + +G+L +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 2214 -KDAGDYLCVARNKVGD--------DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVD 2264
D G Y+CVARN +G+ + +L+ D P+ D V G ++
Sbjct: 100 RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS--------DVMVAVGEPAVME 151
Query: 2265 CVAT-GLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYT 2323
C G P P ISW DGS + DD R + G L + G Y
Sbjct: 152 CQPPRGHPEPTISWK-KDGSPL------DDKDER----ITIRGGKLMITYTRKSDAGKYV 200
Query: 2324 CFAENQVGKDEMRV-RVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLS 2382
C N VG+ E V + V+ P+ ++ + LAV V D CEA+G+P+P V W
Sbjct: 201 CVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRK 258
Query: 2383 PTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAG--EDRKTVWIHVNVQPP 2440
+ +P S +Y+I D TL I+K D G+YTC+ N G E T+ + V +PP
Sbjct: 259 DDGE-LPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 2441 KINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVL----PAPYYGNRIT 2496
P ++ A G C+A G P P + W L P +R +
Sbjct: 316 HFVVKPRD-----QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 2497 VHGNGSLDIRSLRKSDSVQLVCMARNEGGE--ARLILQLT-VLEPMEKPIFHDPISEKIT 2553
V G L I ++++SD +C N G + L++T V+ P+ +
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 2554 AMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGA 2613
A+ G T L+C A G+P P+++W + Q R +G+L I D G
Sbjct: 431 AVDG-TFVLSCVATGSPVPTILW---RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGR 486
Query: 2614 YRCVARNAAG 2623
Y C+A +G
Sbjct: 487 YTCIASTPSG 496
Score = 143 bits (361), Expect = 2e-33
Identities = 137/512 (26%), Positives = 200/512 (39%), Gaps = 42/512 (8%)
Query: 1950 PQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV-WQTVSPVEGRITLHENR 2008
P + H D+ V G+ + C A+G P P I W RV P R+ L
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 2009 TLSIK----EASFSDRGVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGL 2063
++ S D GVY CVA N G A S L VA L Q ++ + G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP-SDVMVAVGE 146
Query: 2064 SIHIHCTA-KAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYEC 2122
+ C + P P++ W DG+ + G L I D+G+Y C
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDKD----ERITIRGGKLMITYTRKSDAGKYVC 201
Query: 2123 VAANLVGSARRTV-QLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR 2181
V N+VG V +L V + + P V + + C A GDP P + WR
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVK----RPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 2182 LPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG--DDYVVLKVDVV 2239
+ SR ++ + TL ++ VT D G Y CVA N VG + L V V
Sbjct: 258 KDDGELPK------SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVG 311
Query: 2240 MKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDG-SLVNSFMQSDDSGGRT 2298
+P K D V G + C ATG P P I W +L+ S+ S
Sbjct: 312 SEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS--- 367
Query: 2299 KRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG----KDEMRVRVKVVTAPATIRNKTYL 2354
R+ V G L V + G Y C N G K + V + P + + +
Sbjct: 368 -RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 426
Query: 2355 AVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSG 2414
V ++C A G P+P + W ++ T + + ++G L I+ A+ D+G
Sbjct: 427 NQTVAVDGTFVLSCVATGSPVPTILWRKD-GVLVSTQDSRIKQLENGVLQIRYAKLGDTG 485
Query: 2415 NYTCLVRNSAGEDRKTVWIHVN-----VQPPK 2441
YTC+ +GE + +I V VQPP+
Sbjct: 486 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 517
Score = 134 bits (337), Expect = 1e-30
Identities = 139/499 (27%), Positives = 203/499 (40%), Gaps = 61/499 (12%)
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLS-----PTNKVIPTSSEKYQIYQDGTLLIQKA---- 2408
V G+ T+ C+A+G P P + W T+K P S + G+L +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR--MLLPSGSLFFLRIVHGR 97
Query: 2409 -QRSDSGNYTCLVRNSAGED-RKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466
R D G Y C+ RN GE + V + NP+ + + A G +++C
Sbjct: 98 KSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-----MVAVGEPAVMEC 152
Query: 2467 KA-EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG 2525
+ G P P + W P RIT+ G G L I RKSD+ + VC+ N G
Sbjct: 153 QPPRGHPEPTISWKKDGS---PLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVG 208
Query: 2526 EARL-ILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
E + +LTVLE +P F S + + C A G P P++ W +G
Sbjct: 209 ERESEVAELTVLE---RPSFVKRPSN-LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
Query: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSL--KVGLKPE--AN 2640
+S R+ + D L I +++ D G+Y CVA N G E +L +VG +P
Sbjct: 265 KS-----RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 2641 KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHL----EGPQTLGRVSLLDNGTL 2696
K +V++ G T+ C G Q W +L + PQ+ R S+ G L
Sbjct: 320 KPRDQVVAL--GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 2697 TVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGN------- 2749
T+ D G Y+C+ G +T + V I P PVI P N
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV---IADRPPPVIRQGPVNQTVAVDG 434
Query: 2750 TVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQ-GSLTIQHATQRDAGFY 2808
T L+C+A G P I W K GV +R + G L I++A D G Y
Sbjct: 435 TFVLSCVATGSPVPTILWR-------KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
Query: 2809 KCMAKNILGSDSKTTYIHV 2827
C+A G + + YI V
Sbjct: 488 TCIASTPSGEATWSAYIEV 506
Score = 131 bits (329), Expect = 1e-29
Identities = 140/540 (25%), Positives = 216/540 (40%), Gaps = 51/540 (9%)
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P +EH +D V G ++C A G P P I W G V ++D R+ R
Sbjct: 29 PRIVEHP--SDLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERV----ETDKDDPRSHR- 80
Query: 2302 VVFNNGTLYFNEV-----GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAV 2356
++ +G+L+F + +EG Y C A N +G+ V + V
Sbjct: 81 MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 140
Query: 2357 QVPYGDVVTVACEA-KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
V G+ + C+ +G P P ++W + E+ I + G L+I ++SD+G
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITI-RGGKLMITYTRKSDAGK 198
Query: 2416 YTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPR 2475
Y C+ N GE V ++ P P+ + + +A C+A G P P
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE-----FKCEARGDPVPT 253
Query: 2476 VLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535
V W +G LP +R + + +L IR + D C+A N G+A LTV
Sbjct: 254 VRWRKDDGE-LPK----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 2536 LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL----QSGQQLQ 2591
E P F +++ A+ G T++ C A G P P++ W +L Q Q
Sbjct: 309 QVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 367
Query: 2592 RFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV-----GLKPEANKQYHNL 2646
RF G L I+ + D G Y C N AG L+V P +Q
Sbjct: 368 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 427
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDR 2706
++ T L C G+ W +G+ + + R+ L+NG L +R A + D
Sbjct: 428 QTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVSTQDS--RIKQLENGVLQIRYAKLGDT 484
Query: 2707 GTYVCRMETEYGPSVTSIPVIVIAY-----PPR------ITSEPT-PVIYTRPGNTVKLN 2754
G Y C T G + S + V + PPR I S P+ P + NTV L+
Sbjct: 485 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 544
Score = 104 bits (260), Expect = 1e-21
Identities = 111/411 (27%), Positives = 167/411 (40%), Gaps = 51/411 (12%)
Query: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEG--------------V 2484
PP+I +P+ + I + G ++CKAEG PTP + W + G +
Sbjct: 28 PPRIVEHPSDL-----IVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRM 81
Query: 2485 VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF 2544
+LP+ VHG S + D VC+ARN GEA ++ +E I
Sbjct: 82 LLPSGSLFFLRIVHGRKS-------RPDEGVYVCVARNYLGEA-----VSHNASLEVAIL 129
Query: 2545 HDPISEK---ITAMAGHTISLNCSAA-GTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM 2600
D + + G + C G P P++ W +G+ L + G
Sbjct: 130 RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITI---RGGK 185
Query: 2601 LHISGLSSVDAGAYRCVARNAAGHTERLVS-LKVGLKPEANKQYHNLVSIINGETLKLPC 2659
L I+ DAG Y CV N G E V+ L V +P K+ NL ++ ++ + C
Sbjct: 186 LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD-DSAEFKC 244
Query: 2660 TPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGP 2719
G W +G E P++ R + D+ TL +R+ + D G+Y C E G
Sbjct: 245 EARGDPVPTVRWRKDDG---ELPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 299
Query: 2720 SVTS--IPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKA 2777
+ S + V V + PP +P + G TV C A G P+ I W +L
Sbjct: 300 AEASATLTVQVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLF 358
Query: 2778 GVQARLYGNRFLHPQ-GSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
Q +RF Q G LTI + + D G+Y C N+ GS Y+ V
Sbjct: 359 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 90.1 bits (222), Expect = 3e-17
Identities = 60/191 (31%), Positives = 84/191 (43%), Gaps = 11/191 (5%)
Query: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALM---TPNTRIQRF 1905
+G +P P+ V F CEATG P+P + W + + L+ P RF
Sbjct: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 1906 EVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVT----VQQPQILASHYQDVT 1961
V + G L I VQ D G Y+C N+ G L VT + P ++ + T
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 1962 VYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRG 2021
V + T + C+A G+P P I W R+ VS + RI EN L I+ A D G
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTG 485
Query: 2022 VYKCVASNAAG 2032
Y C+AS +G
Sbjct: 486 RYTCIASTPSG 496
Score = 53.5 bits (127), Expect = 3e-06
Identities = 55/214 (25%), Positives = 78/214 (36%), Gaps = 31/214 (14%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDS--KFSILSSGWLRIKS 544
RDQ V G C + P+IFW L P S +FS+ +G L I +
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
Query: 545 MEPSDSGLYQC-------------IAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP 591
++ SD G Y C +V D + V+ Q P Q D +
Sbjct: 382 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV---- 437
Query: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLANT--SHVYMLPNGTLSIPKVQVSDSGYY 649
L C A P + W R L +T S + L NG L I ++ D+G Y
Sbjct: 438 -----LSCVATGSPVPTILW-----RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
Query: 650 RCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRP 683
C+A G ++ I V + G + R P
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDP 521
Score = 50.4 bits (119), Expect = 2e-05
Identities = 51/184 (27%), Positives = 73/184 (39%), Gaps = 17/184 (9%)
Query: 488 DQTVLEGGPCQLSCNV-KASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
D V G P + C + P+I W DGS P+DD D + +I G L I
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWK-KDGS----PLDDKDERITI-RGGKLMITYTR 192
Query: 547 PSDSGLYQCIA--QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
SD+G Y C+ V + + +++ PS K + +S C A
Sbjct: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGD 249
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
P + W R+ +L S + + TL I KV D G Y CVA N G +
Sbjct: 250 PVPTVRW----RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304
Query: 665 GITV 668
+TV
Sbjct: 305 TLTV 308
Score = 47.0 bits (110), Expect = 3e-04
Identities = 53/198 (26%), Positives = 81/198 (40%), Gaps = 22/198 (11%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG---WLRIKS 544
D V +G P L+C + +P+I W G ++ DDP S +L SG +LRI
Sbjct: 37 DLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
Query: 545 MEPS--DSGLYQCIAQVRDEMDRMV-----YRVLVQSPSTQPAEKDTVTIGKNPGESVTL 597
S D G+Y C+A R+ + V V + + D + GE +
Sbjct: 96 GRKSRPDEGVYVCVA--RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA---VGEPAVM 150
Query: 598 PCN-ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
C PE +SW ++ + L + + G L I + SD+G Y CV N
Sbjct: 151 ECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 657 QGADHFTVG-ITVTKKGS 673
G V +TV ++ S
Sbjct: 207 VGERESEVAELTVLERPS 224
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 156 bits (394), Expect = 3e-37
Identities = 138/511 (27%), Positives = 210/511 (41%), Gaps = 54/511 (10%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P + + P + V+ C+A G+P P + W K + +L +G+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 1913 LVIRKV-----QVQDRGQYMCTASNL------HGLDRMVVLLSVTVQQPQILASHYQDVT 1961
L ++ D G Y+C A N H V +L +Q + DV
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ------NPSDVM 141
Query: 1962 VYLGDTIAMECLA-KGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDR 2020
V +G+ MEC +G P P ISW ++ + + RIT+ + L I SD
Sbjct: 142 VAVGEPAVMECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGK-LMITYTRKSDA 196
Query: 2021 GVYKCVASNAAGA-DSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
G Y CV +N G +S L V P + ++ N+++ S C A+ P+P+V
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTV 254
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
RW DG ++ S++ + + TL IR + D G Y CVA N+VG A + L V
Sbjct: 255 RWRKDDG-ELPKSRYE-----IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 2140 QRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSF----- 2194
Q + PR V G T+ C A+G+P P I WR + + LFS+
Sbjct: 309 QVGSEPPHFV-VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ--NLLFSYQPPQS 365
Query: 2195 DSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGD----DYVVLKVDVVMKPAKIEHKEE 2250
SR V G L + +V D G Y+C N G Y+ + + +P + +
Sbjct: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 425
Query: 2251 NDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLY 2310
+ V G + CVATG P P I W DG LV++ + R NG L
Sbjct: 426 VNQTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVST---------QDSRIKQLENGVLQ 475
Query: 2311 FNEVGMREEGDYTCFAENQVGKDEMRVRVKV 2341
+ + G YTC A G+ ++V
Sbjct: 476 IRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Score = 148 bits (374), Expect = 7e-35
Identities = 134/490 (27%), Positives = 201/490 (41%), Gaps = 57/490 (11%)
Query: 2158 VRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTD---- 2213
V G L+C A G P P I W +R+ S + +G+L +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 2214 -KDAGDYLCVARNKVGD--------DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVD 2264
D G Y+CVARN +G+ + +L+ D P+ D V G ++
Sbjct: 100 RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS--------DVMVAVGEPAVME 151
Query: 2265 CVAT-GLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYT 2323
C G P P ISW DGS + DD R + G L + G Y
Sbjct: 152 CQPPRGHPEPTISWK-KDGSPL------DDKDER----ITIRGGKLMITYTRKSDAGKYV 200
Query: 2324 CFAENQVGKDEMRV-RVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLS 2382
C N VG+ E V + V+ P+ ++ + LAV V D CEA+G+P+P V W
Sbjct: 201 CVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRK 258
Query: 2383 PTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAG--EDRKTVWIHVNVQPP 2440
+ +P S +Y+I D TL I+K D G+YTC+ N G E T+ + V +PP
Sbjct: 259 DDGE-LPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 2441 KINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVL----PAPYYGNRIT 2496
P ++ A G C+A G P P + W L P +R +
Sbjct: 316 HFVVKPRD-----QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
Query: 2497 VHGNGSLDIRSLRKSDSVQLVCMARNEGGE--ARLILQLT-VLEPMEKPIFHDPISEKIT 2553
V G L I ++++SD +C N G + L++T V+ P+ +
Sbjct: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 2554 AMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGA 2613
A+ G T L+C A G+P P+++W + Q R +G+L I D G
Sbjct: 431 AVDG-TFVLSCVATGSPVPTILW---RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGR 486
Query: 2614 YRCVARNAAG 2623
Y C+A +G
Sbjct: 487 YTCIASTPSG 496
Score = 143 bits (361), Expect = 2e-33
Identities = 137/512 (26%), Positives = 200/512 (39%), Gaps = 42/512 (8%)
Query: 1950 PQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV-WQTVSPVEGRITLHENR 2008
P + H D+ V G+ + C A+G P P I W RV P R+ L
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 2009 TLSIK----EASFSDRGVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGL 2063
++ S D GVY CVA N G A S L VA L Q ++ + G
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP-SDVMVAVGE 146
Query: 2064 SIHIHCTA-KAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYEC 2122
+ C + P P++ W DG+ + G L I D+G+Y C
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDKD----ERITIRGGKLMITYTRKSDAGKYVC 201
Query: 2123 VAANLVGSARRTV-QLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR 2181
V N+VG V +L V + + P V + + C A GDP P + WR
Sbjct: 202 VGTNMVGERESEVAELTVLERPSFVK----RPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 2182 LPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG--DDYVVLKVDVV 2239
+ SR ++ + TL ++ VT D G Y CVA N VG + L V V
Sbjct: 258 KDDGELPK------SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVG 311
Query: 2240 MKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDG-SLVNSFMQSDDSGGRT 2298
+P K D V G + C ATG P P I W +L+ S+ S
Sbjct: 312 SEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS--- 367
Query: 2299 KRYVVFNNGTLYFNEVGMREEGDYTCFAENQVG----KDEMRVRVKVVTAPATIRNKTYL 2354
R+ V G L V + G Y C N G K + V + P + + +
Sbjct: 368 -RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 426
Query: 2355 AVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSG 2414
V ++C A G P+P + W ++ T + + ++G L I+ A+ D+G
Sbjct: 427 NQTVAVDGTFVLSCVATGSPVPTILWRKD-GVLVSTQDSRIKQLENGVLQIRYAKLGDTG 485
Query: 2415 NYTCLVRNSAGEDRKTVWIHVN-----VQPPK 2441
YTC+ +GE + +I V VQPP+
Sbjct: 486 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 517
Score = 134 bits (337), Expect = 1e-30
Identities = 139/499 (27%), Positives = 203/499 (40%), Gaps = 61/499 (12%)
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLS-----PTNKVIPTSSEKYQIYQDGTLLIQKA---- 2408
V G+ T+ C+A+G P P + W T+K P S + G+L +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR--MLLPSGSLFFLRIVHGR 97
Query: 2409 -QRSDSGNYTCLVRNSAGED-RKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC 2466
R D G Y C+ RN GE + V + NP+ + + A G +++C
Sbjct: 98 KSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-----MVAVGEPAVMEC 152
Query: 2467 KA-EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG 2525
+ G P P + W P RIT+ G G L I RKSD+ + VC+ N G
Sbjct: 153 QPPRGHPEPTISWKKDGS---PLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVG 208
Query: 2526 EARL-ILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
E + +LTVLE +P F S + + C A G P P++ W +G
Sbjct: 209 ERESEVAELTVLE---RPSFVKRPSN-LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
Query: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSL--KVGLKPE--AN 2640
+S R+ + D L I +++ D G+Y CVA N G E +L +VG +P
Sbjct: 265 KS-----RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
Query: 2641 KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHL----EGPQTLGRVSLLDNGTL 2696
K +V++ G T+ C G Q W +L + PQ+ R S+ G L
Sbjct: 320 KPRDQVVAL--GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 2697 TVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGN------- 2749
T+ D G Y+C+ G +T + V I P PVI P N
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV---IADRPPPVIRQGPVNQTVAVDG 434
Query: 2750 TVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQ-GSLTIQHATQRDAGFY 2808
T L+C+A G P I W K GV +R + G L I++A D G Y
Sbjct: 435 TFVLSCVATGSPVPTILWR-------KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
Query: 2809 KCMAKNILGSDSKTTYIHV 2827
C+A G + + YI V
Sbjct: 488 TCIASTPSGEATWSAYIEV 506
Score = 131 bits (329), Expect = 1e-29
Identities = 140/540 (25%), Positives = 216/540 (40%), Gaps = 51/540 (9%)
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P +EH +D V G ++C A G P P I W G V ++D R+ R
Sbjct: 29 PRIVEHP--SDLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERV----ETDKDDPRSHR- 80
Query: 2302 VVFNNGTLYFNEV-----GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAV 2356
++ +G+L+F + +EG Y C A N +G+ V + V
Sbjct: 81 MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 140
Query: 2357 QVPYGDVVTVACEA-KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
V G+ + C+ +G P P ++W + E+ I + G L+I ++SD+G
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISW-KKDGSPLDDKDERITI-RGGKLMITYTRKSDAGK 198
Query: 2416 YTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPR 2475
Y C+ N GE V ++ P P+ + + +A C+A G P P
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE-----FKCEARGDPVPT 253
Query: 2476 VLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTV 2535
V W +G LP +R + + +L IR + D C+A N G+A LTV
Sbjct: 254 VRWRKDDGE-LPK----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Query: 2536 LEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL----QSGQQLQ 2591
E P F +++ A+ G T++ C A G P P++ W +L Q Q
Sbjct: 309 QVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 367
Query: 2592 RFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKV-----GLKPEANKQYHNL 2646
RF G L I+ + D G Y C N AG L+V P +Q
Sbjct: 368 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 427
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDR 2706
++ T L C G+ W +G+ + + R+ L+NG L +R A + D
Sbjct: 428 QTVAVDGTFVLSCVATGSPVPTILWR-KDGVLVSTQDS--RIKQLENGVLQIRYAKLGDT 484
Query: 2707 GTYVCRMETEYGPSVTSIPVIVIAY-----PPR------ITSEPT-PVIYTRPGNTVKLN 2754
G Y C T G + S + V + PPR I S P+ P + NTV L+
Sbjct: 485 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 544
Score = 104 bits (260), Expect = 1e-21
Identities = 111/411 (27%), Positives = 167/411 (40%), Gaps = 51/411 (12%)
Query: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEG--------------V 2484
PP+I +P+ + I + G ++CKAEG PTP + W + G +
Sbjct: 28 PPRIVEHPSDL-----IVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRM 81
Query: 2485 VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF 2544
+LP+ VHG S + D VC+ARN GEA ++ +E I
Sbjct: 82 LLPSGSLFFLRIVHGRKS-------RPDEGVYVCVARNYLGEA-----VSHNASLEVAIL 129
Query: 2545 HDPISEK---ITAMAGHTISLNCSAA-GTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM 2600
D + + G + C G P P++ W +G+ L + G
Sbjct: 130 RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWK-KDGSPLDDKDERITI---RGGK 185
Query: 2601 LHISGLSSVDAGAYRCVARNAAGHTERLVS-LKVGLKPEANKQYHNLVSIINGETLKLPC 2659
L I+ DAG Y CV N G E V+ L V +P K+ NL ++ ++ + C
Sbjct: 186 LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD-DSAEFKC 244
Query: 2660 TPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGP 2719
G W +G E P++ R + D+ TL +R+ + D G+Y C E G
Sbjct: 245 EARGDPVPTVRWRKDDG---ELPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 299
Query: 2720 SVTS--IPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKA 2777
+ S + V V + PP +P + G TV C A G P+ I W +L
Sbjct: 300 AEASATLTVQVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLF 358
Query: 2778 GVQARLYGNRFLHPQ-GSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
Q +RF Q G LTI + + D G+Y C N+ GS Y+ V
Sbjct: 359 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 90.1 bits (222), Expect = 3e-17
Identities = 60/191 (31%), Positives = 84/191 (43%), Gaps = 11/191 (5%)
Query: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALM---TPNTRIQRF 1905
+G +P P+ V F CEATG P+P + W + + L+ P RF
Sbjct: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 1906 EVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVT----VQQPQILASHYQDVT 1961
V + G L I VQ D G Y+C N+ G L VT + P ++ + T
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 1962 VYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRG 2021
V + T + C+A G+P P I W R+ VS + RI EN L I+ A D G
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTG 485
Query: 2022 VYKCVASNAAG 2032
Y C+AS +G
Sbjct: 486 RYTCIASTPSG 496
Score = 53.5 bits (127), Expect = 3e-06
Identities = 55/214 (25%), Positives = 78/214 (36%), Gaps = 31/214 (14%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDS--KFSILSSGWLRIKS 544
RDQ V G C + P+IFW L P S +FS+ +G L I +
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
Query: 545 MEPSDSGLYQC-------------IAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP 591
++ SD G Y C +V D + V+ Q P Q D +
Sbjct: 382 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV---- 437
Query: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLANT--SHVYMLPNGTLSIPKVQVSDSGYY 649
L C A P + W R L +T S + L NG L I ++ D+G Y
Sbjct: 438 -----LSCVATGSPVPTILW-----RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
Query: 650 RCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRP 683
C+A G ++ I V + G + R P
Sbjct: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDP 521
Score = 50.4 bits (119), Expect = 2e-05
Identities = 51/184 (27%), Positives = 73/184 (39%), Gaps = 17/184 (9%)
Query: 488 DQTVLEGGPCQLSCNV-KASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
D V G P + C + P+I W DGS P+DD D + +I G L I
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWK-KDGS----PLDDKDERITI-RGGKLMITYTR 192
Query: 547 PSDSGLYQCIA--QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
SD+G Y C+ V + + +++ PS K + +S C A
Sbjct: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGD 249
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
P + W R+ +L S + + TL I KV D G Y CVA N G +
Sbjct: 250 PVPTVRW----RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304
Query: 665 GITV 668
+TV
Sbjct: 305 TLTV 308
Score = 47.0 bits (110), Expect = 3e-04
Identities = 53/198 (26%), Positives = 81/198 (40%), Gaps = 22/198 (11%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG---WLRIKS 544
D V +G P L+C + +P+I W G ++ DDP S +L SG +LRI
Sbjct: 37 DLIVSKGEPATLNCKAEGRPTPTIEW-YKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
Query: 545 MEPS--DSGLYQCIAQVRDEMDRMV-----YRVLVQSPSTQPAEKDTVTIGKNPGESVTL 597
S D G+Y C+A R+ + V V + + D + GE +
Sbjct: 96 GRKSRPDEGVYVCVA--RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA---VGEPAVM 150
Query: 598 PCN-ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
C PE +SW ++ + L + + G L I + SD+G Y CV N
Sbjct: 151 ECQPPRGHPEPTISW----KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 657 QGADHFTVG-ITVTKKGS 673
G V +TV ++ S
Sbjct: 207 VGERESEVAELTVLERPS 224
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 152 bits (383), Expect = 6e-36
Identities = 171/646 (26%), Positives = 248/646 (38%), Gaps = 88/646 (13%)
Query: 2039 RLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQF-LHG 2097
RL PP I E ++ + G ++C A+ P P++ W DG ++ +
Sbjct: 39 RLRQEDFPPRI-VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRS 96
Query: 2098 NLFVFPNGTLYIRNL-----APKDSGRYECVAANLVGSA-RRTVQLNVQRAAANARITGT 2151
+ + P+G+L+ + + D G Y CVA N +G A R L V + R
Sbjct: 97 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFR---Q 153
Query: 2152 SPRRTDVRYGGTLKLDCSAS-GDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKS 2210
+P V G L+C G P P I W+ R+ D + RI + G L++ +
Sbjct: 154 NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDK----EERISI-RGGKLMISN 208
Query: 2211 VTDKDAGDYLCVARNKVGD-DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATG 2269
DAG Y CV N VG+ D ++ V +P + + + V ++ C G
Sbjct: 209 TRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFL--RRPINQVVLEEEAVEFRCQVQG 266
Query: 2270 LPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQ 2329
P P + W D L RY + ++ TL + +EG Y C AEN+
Sbjct: 267 DPQPTVRWKKDDADLPRG------------RYDIKDDYTLRIKKTMSTDEGTYMCIAENR 314
Query: 2330 VGKDEMRVRVKVVTAPA-TIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTW-------- 2380
VGK E + V P +R + + Q G VT CE KG P P V W
Sbjct: 315 VGKMEASATLTVRAPPQFVVRPRDQIVAQ---GRTVTFPCETKGNPQPAVFWQKEGSQNL 371
Query: 2381 LSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPP 2440
L P P S + + G L I QRSD+G Y C AG + V
Sbjct: 372 LFPNQPQQPNS--RCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVT---D 426
Query: 2441 KINGNPNPIT---TVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITV 2497
+ P PI + A L+ CKA G P P + W EG P R T+
Sbjct: 427 VLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISW-LKEGFTFPG--RDPRATI 483
Query: 2498 HGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAG 2557
G+L I++LR SD+ C+A + GE L V E +G
Sbjct: 484 QEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE------------------SG 525
Query: 2558 HTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLH-----ISGLSSVDAG 2612
TIS N + P P P TD+ + G L I S +
Sbjct: 526 ATISKNYDLSDLPGPP---SKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSN 582
Query: 2613 AYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLP 2658
+++ V A H + + GL+P N Y +V IN + L P
Sbjct: 583 SWQTV----ANHVKTTLYTVRGLRP--NTIYLFMVRAINPQGLSDP 622
Score = 134 bits (338), Expect = 1e-30
Identities = 134/525 (25%), Positives = 206/525 (39%), Gaps = 50/525 (9%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P + + P V V+ T C+A G+P P + W K + +L +G+
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 1913 LVIRKV-----QVQDRGQYMCTASNLHG--LDRMVVLLSVTVQQPQILASHYQDVTVYLG 1965
L ++ D G Y+C A N G + R L ++ + DV V G
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD--FRQNPTDVVVAAG 163
Query: 1966 DTIAMECL-AKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYK 2024
+ +EC +G P P I W ++ + E RI++ + L I SD G+Y
Sbjct: 164 EPAILECQPPRGHPEPTIYW----KKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYT 218
Query: 2025 CVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVL 2083
CV +N G DS L V P + + + + L ++ C + P P+VRW
Sbjct: 219 CVGTNMVGERDSDPAELTVFERPTFL-RRPINQVVLEEE-AVEFRCQVQGDPQPTVRWKK 276
Query: 2084 GDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
D R G + + TL I+ D G Y C+A N VG + L V+
Sbjct: 277 DDADLPR------GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 330
Query: 2144 ANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALF-----SFDSRI 2198
PR V G T+ C G+P P + W+ + + LF +SR
Sbjct: 331 QFV----VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQ--NLLFPNQPQQPNSRC 384
Query: 2199 KVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDV----VMKPAKIEHKEENDHK 2254
V G L + ++ DAG Y+C A G +++V +P I + +
Sbjct: 385 SVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQT 444
Query: 2255 VFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEV 2314
+ G + C ATG P P ISW L +G GR R + GTL +
Sbjct: 445 LAVDGTALLKCKATGDPLPVISW-LKEGFTF---------PGRDPRATIQEQGTLQIKNL 494
Query: 2315 GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVP 2359
+ + G YTC A + G+ + V + ATI +K Y +P
Sbjct: 495 RISDTGTYTCVATSSSGETSWSAVLDVTESGATI-SKNYDLSDLP 538
Score = 131 bits (330), Expect = 8e-30
Identities = 133/498 (26%), Positives = 199/498 (39%), Gaps = 58/498 (11%)
Query: 2356 VQVPYGDVVTVACEAKGEPMPKVTWLSP-----TNKVIPTSSEKYQIYQDGTLLIQKA-- 2408
V V G+ T+ C+A+G P P + W T+K P S + G+L +
Sbjct: 56 VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHR--MLLPSGSLFFLRIVH 113
Query: 2409 ---QRSDSGNYTCLVRNSAGED-RKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLI 2464
+ D G+Y C+ RN GE + + V + NP + + A G ++
Sbjct: 114 GRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV-----VVAAGEPAIL 168
Query: 2465 DCKA-EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNE 2523
+C+ G P P + W + + RI++ G G L I + RKSD+ C+ N
Sbjct: 169 ECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRG-GKLMISNTRKSDAGMYTCVGTNM 224
Query: 2524 GGEARLI-LQLTVLEPMEKPIF-HDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNG 2581
GE +LTV E +P F PI++ + + + C G P P++ W +
Sbjct: 225 VGERDSDPAELTVFE---RPTFLRRPINQVV--LEEEAVEFRCQVQGDPQPTVRWK-KDD 278
Query: 2582 TDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANK 2641
DL G R+ K D L I S D G Y C+A N G E +L V P+
Sbjct: 279 ADLPRG----RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV 334
Query: 2642 QYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGP----QTLGRVSLLDNGTLT 2697
+ + + + G T+ PC G Q W +L P Q R S+ G LT
Sbjct: 335 RPRDQI-VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 393
Query: 2698 VREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGN-------T 2750
+ D G Y+C+ T G + + V +T P P+I P N T
Sbjct: 394 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDV---LTDRPPPIILQGPANQTLAVDGT 450
Query: 2751 VKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRF-LHPQGSLTIQHATQRDAGFYK 2809
L C A G P I+W LK G R + QG+L I++ D G Y
Sbjct: 451 ALLKCKATGDPLPVISW-------LKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 503
Query: 2810 CMAKNILGSDSKTTYIHV 2827
C+A + G S + + V
Sbjct: 504 CVATSSSGETSWSAVLDV 521
Score = 121 bits (304), Expect = 9e-27
Identities = 126/508 (24%), Positives = 188/508 (37%), Gaps = 34/508 (6%)
Query: 1950 PQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV-WQTVSPVEGRITLHENR 2008
P + H DV V G+ + C A+G P P I W RV P R+ L
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 2009 TLSIK----EASFSDRGVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGL 2063
++ S D G Y CVA N G A S L VA L Q + + + G
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTD-VVVAAGE 164
Query: 2064 SIHIHC-TAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYEC 2122
+ C + P P++ W D +I + G L I N D+G Y C
Sbjct: 165 PAILECQPPRGHPEPTIYW-KKDKVRIDDKE----ERISIRGGKLMISNTRKSDAGMYTC 219
Query: 2123 VAANLVGSA-RRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR 2181
V N+VG +L V R P V ++ C GDP P + W+
Sbjct: 220 VGTNMVGERDSDPAELTVFERPTFLR----RPINQVVLEEEAVEFRCQVQGDPQPTVRWK 275
Query: 2182 LPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMK 2241
+ R + + TL +K D G Y+C+A N+VG + V
Sbjct: 276 KDDADLP------RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 329
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P + D V G + C G P P + W +GS + + + R
Sbjct: 330 PQFV--VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQ-KEGS--QNLLFPNQPQQPNSRC 384
Query: 2302 VVFNNGTLYFNEVGMREEGDYTCFAENQVG----KDEMRVRVKVVTAPATIRNKTYLAVQ 2357
V G L + + G Y C A G K ++ V + P I +
Sbjct: 385 SVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQT 444
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYT 2417
+ + C+A G+P+P ++WL P + I + GTL I+ + SD+G YT
Sbjct: 445 LAVDGTALLKCKATGDPLPVISWLK-EGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 503
Query: 2418 CLVRNSAGEDRKTVWIHVNVQPPKINGN 2445
C+ +S+GE + + V I+ N
Sbjct: 504 CVATSSSGETSWSAVLDVTESGATISKN 531
Score = 118 bits (295), Expect = 9e-26
Identities = 130/487 (26%), Positives = 194/487 (39%), Gaps = 46/487 (9%)
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P +EH +D V G ++C A G P P I W DG V ++D R+ R
Sbjct: 47 PRIVEHP--SDVIVSKGEPTTLNCKAEGRPTPTIEW-YKDGERV----ETDKDDPRSHR- 98
Query: 2302 VVFNNGTLYFNEV--GMR---EEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAV 2356
++ +G+L+F + G R +EG Y C A N +G+ R V + V
Sbjct: 99 MLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV 158
Query: 2357 QVPYGDVVTVACEA-KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
V G+ + C+ +G P P + W +KV E+ + G L+I ++SD+G
Sbjct: 159 VVAAGEPAILECQPPRGHPEPTIYWKK--DKVRIDDKEERISIRGGKLMISNTRKSDAGM 216
Query: 2416 YTCLVRNSAGE-DRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTP 2474
YTC+ N GE D + V +P + N + E C+ +G P P
Sbjct: 217 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVE------FRCQVQGDPQP 270
Query: 2475 RVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLT 2534
V W + LP R + + +L I+ +D +C+A N G+ LT
Sbjct: 271 TVRWK-KDDADLPR----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT 325
Query: 2535 VLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL----QSGQQL 2590
V P P F ++I A G T++ C G P P++ W +L Q Q
Sbjct: 326 VRAP---PQFVVRPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPN 381
Query: 2591 QRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVG------LKPEANKQYH 2644
R G L I+ + DAG Y C A AG L+V P +
Sbjct: 382 SRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPA 441
Query: 2645 NLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVF 2704
N ++G L L C G SW L G G R ++ + GTL ++ +
Sbjct: 442 NQTLAVDGTAL-LKCKATGDPLPVISW-LKEGFTFPGRDP--RATIQEQGTLQIKNLRIS 497
Query: 2705 DRGTYVC 2711
D GTY C
Sbjct: 498 DTGTYTC 504
Score = 107 bits (267), Expect = 2e-22
Identities = 108/400 (27%), Positives = 166/400 (41%), Gaps = 50/400 (12%)
Query: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEG--------------V 2484
PP+I +P+ + I + G ++CKAEG PTP + W + +G +
Sbjct: 46 PPRIVEHPSDV-----IVSKGEPTTLNCKAEGRPTPTIEW-YKDGERVETDKDDPRSHRM 99
Query: 2485 VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF 2544
+LP+ VHG S K D VC+ARN GEA ++ +E +
Sbjct: 100 LLPSGSLFFLRIVHGRRS-------KPDEGSYVCVARNYLGEA-----VSRNASLEVALL 147
Query: 2545 HDPISEK---ITAMAGHTISLNCSAA-GTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM 2600
D + + AG L C G P P++ W ++ + +R + G
Sbjct: 148 RDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYW---KKDKVRIDDKEERISIRG-GK 203
Query: 2601 LHISGLSSVDAGAYRCVARNAAGHTER-LVSLKVGLKPEANKQYHNLVSIINGETLKLPC 2659
L IS DAG Y CV N G + L V +P ++ N V ++ E ++ C
Sbjct: 204 LMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQV-VLEEEAVEFRC 262
Query: 2660 TPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGP 2719
G Q W + + P+ GR + D+ TL +++ D GTY+C E G
Sbjct: 263 QVQGDPQPTVRWKKDDA---DLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK 317
Query: 2720 SVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGV 2779
S + V A PP+ P I + G TV C G P+ + W+ +L
Sbjct: 318 MEASATLTVRA-PPQFVVRPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPN 375
Query: 2780 QARLYGNR-FLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
Q + +R + P G LTI + + DAG+Y C A + GS
Sbjct: 376 QPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGS 415
Score = 92.4 bits (228), Expect = 6e-18
Identities = 73/236 (30%), Positives = 102/236 (43%), Gaps = 23/236 (9%)
Query: 1839 GGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTP 1898
G AS ++ PQ + + + T T FPCE G P+P V W K + L+ P
Sbjct: 316 GKMEASATLTVRAPPQFVVRPRDQIVAQGRTVT-FPCETKGNPQPAVFWQKEGSQNLLFP 374
Query: 1899 NTRIQ---RFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTV----QQPQ 1951
N Q R V G L I +Q D G Y+C A + G L VT + P
Sbjct: 375 NQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPP 434
Query: 1952 ILASHYQDVTVYLGDTIAMECLAKGTPAPQISWI-----FPDRRVWQTVSPVEGRITLHE 2006
I+ + T+ + T ++C A G P P ISW+ FP R + R T+ E
Sbjct: 435 IILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGR---------DPRATIQE 485
Query: 2007 NRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQE-KLENISLPP 2061
TL IK SD G Y CVA++++G S + L V I + L ++ PP
Sbjct: 486 QGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPP 541
Score = 69.3 bits (168), Expect = 5e-11
Identities = 51/202 (25%), Positives = 84/202 (41%), Gaps = 27/202 (13%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMD--DPDSKFSILSSGWLRIKS 544
RDQ V +G C K + P++FW L P P+S+ S+ +G L I +
Sbjct: 337 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 396
Query: 545 MEPSDSGLYQCIA-------------QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP 591
++ SD+G Y C A +V D + +++Q P+ Q D +
Sbjct: 397 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL---- 452
Query: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRC 651
L C A P +SW+ + + GTL I +++SD+G Y C
Sbjct: 453 -----LKCKATGDPLPVISWL---KEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTC 504
Query: 652 VAVNQQGADHFTVGITVTKKGS 673
VA + G ++ + VT+ G+
Sbjct: 505 VATSSSGETSWSAVLDVTESGA 526
Score = 65.5 bits (158), Expect = 7e-10
Identities = 48/181 (26%), Positives = 74/181 (40%), Gaps = 23/181 (12%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
+Q VLE + C V+ P++ W D + P ++ I LRIK
Sbjct: 249 NQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL-------PRGRYDIKDDYTLRIKKTMS 301
Query: 548 SDSGLYQCIAQVR-DEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPE 606
+D G Y CIA+ R +M+ + P +D + G +VT PC P+
Sbjct: 302 TDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVA---QGRTVTFPCETKGNPQ 358
Query: 607 AHLSW--------ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ W + PN+ S + P G L+I +Q SD+GYY C A+ G
Sbjct: 359 PAVFWQKEGSQNLLFPNQ----PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 414
Query: 659 A 659
+
Sbjct: 415 S 415
Score = 50.4 bits (119), Expect = 2e-05
Identities = 54/182 (29%), Positives = 73/182 (40%), Gaps = 21/182 (11%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG---WLRIKS 544
D V +G P L+C + +P+I W DG ++ DDP S +L SG +LRI
Sbjct: 55 DVIVSKGEPTTLNCKAEGRPTPTIEW-YKDGERVETDKDDPRSHRMLLPSGSLFFLRIVH 113
Query: 545 MEPS--DSGLYQCIAQVRDEMDRMVYR-----VLVQSPSTQPAEKDTVTIGKNPGESVTL 597
S D G Y C+A R+ + V R V + + D V GE L
Sbjct: 114 GRRSKPDEGSYVCVA--RNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA---GEPAIL 168
Query: 598 PCN-ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
C PE + W RI + S + G L I + SD+G Y CV N
Sbjct: 169 ECQPPRGHPEPTIYWKKDKVRIDDKEERIS----IRGGKLMISNTRKSDAGMYTCVGTNM 224
Query: 657 QG 658
G
Sbjct: 225 VG 226
Score = 46.2 bits (108), Expect = 5e-04
Identities = 44/184 (23%), Positives = 72/184 (39%), Gaps = 17/184 (9%)
Query: 488 DQTVLEGGPCQLSCNV-KASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
D V G P L C + P+I+W K +DD + + SI G L I +
Sbjct: 157 DVVVAAGEPAILECQPPRGHPEPTIYWKKD-----KVRIDDKEERISI-RGGKLMISNTR 210
Query: 547 PSDSGLYQCIA--QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
SD+G+Y C+ V + + + P+ + V + + E+V C
Sbjct: 211 KSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEE---EAVEFRCQVQGD 267
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
P+ + W + + + Y TL I K +D G Y C+A N+ G +
Sbjct: 268 PQPTVRWKKDDADLPRGRYDIKDDY-----TLRIKKTMSTDEGTYMCIAENRVGKMEASA 322
Query: 665 GITV 668
+TV
Sbjct: 323 TLTV 326
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 152 bits (383), Expect = 6e-36
Identities = 171/646 (26%), Positives = 248/646 (38%), Gaps = 88/646 (13%)
Query: 2039 RLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQF-LHG 2097
RL PP I E ++ + G ++C A+ P P++ W DG ++ +
Sbjct: 23 RLRQEDFPPRI-VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRS 80
Query: 2098 NLFVFPNGTLYIRNL-----APKDSGRYECVAANLVGSA-RRTVQLNVQRAAANARITGT 2151
+ + P+G+L+ + + D G Y CVA N +G A R L V + R
Sbjct: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFR---Q 137
Query: 2152 SPRRTDVRYGGTLKLDCSAS-GDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKS 2210
+P V G L+C G P P I W+ R+ D + RI + G L++ +
Sbjct: 138 NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDK----EERISI-RGGKLMISN 192
Query: 2211 VTDKDAGDYLCVARNKVGD-DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATG 2269
DAG Y CV N VG+ D ++ V +P + + + V ++ C G
Sbjct: 193 TRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFL--RRPINQVVLEEEAVEFRCQVQG 250
Query: 2270 LPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQ 2329
P P + W D L RY + ++ TL + +EG Y C AEN+
Sbjct: 251 DPQPTVRWKKDDADLPRG------------RYDIKDDYTLRIKKTMSTDEGTYMCIAENR 298
Query: 2330 VGKDEMRVRVKVVTAPA-TIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTW-------- 2380
VGK E + V P +R + + Q G VT CE KG P P V W
Sbjct: 299 VGKMEASATLTVRAPPQFVVRPRDQIVAQ---GRTVTFPCETKGNPQPAVFWQKEGSQNL 355
Query: 2381 LSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPP 2440
L P P S + + G L I QRSD+G Y C AG + V
Sbjct: 356 LFPNQPQQPNS--RCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVT---D 410
Query: 2441 KINGNPNPIT---TVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITV 2497
+ P PI + A L+ CKA G P P + W EG P R T+
Sbjct: 411 VLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISW-LKEGFTFPG--RDPRATI 467
Query: 2498 HGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAG 2557
G+L I++LR SD+ C+A + GE L V E +G
Sbjct: 468 QEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE------------------SG 509
Query: 2558 HTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLH-----ISGLSSVDAG 2612
TIS N + P P P TD+ + G L I S +
Sbjct: 510 ATISKNYDLSDLPGPP---SKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSN 566
Query: 2613 AYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLP 2658
+++ V A H + + GL+P N Y +V IN + L P
Sbjct: 567 SWQTV----ANHVKTTLYTVRGLRP--NTIYLFMVRAINPQGLSDP 606
Score = 134 bits (338), Expect = 1e-30
Identities = 134/525 (25%), Positives = 206/525 (39%), Gaps = 50/525 (9%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P + + P V V+ T C+A G+P P + W K + +L +G+
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 1913 LVIRKV-----QVQDRGQYMCTASNLHG--LDRMVVLLSVTVQQPQILASHYQDVTVYLG 1965
L ++ D G Y+C A N G + R L ++ + DV V G
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD--FRQNPTDVVVAAG 147
Query: 1966 DTIAMECL-AKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYK 2024
+ +EC +G P P I W ++ + E RI++ + L I SD G+Y
Sbjct: 148 EPAILECQPPRGHPEPTIYW----KKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYT 202
Query: 2025 CVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVL 2083
CV +N G DS L V P + + + + L ++ C + P P+VRW
Sbjct: 203 CVGTNMVGERDSDPAELTVFERPTFL-RRPINQVVLEEE-AVEFRCQVQGDPQPTVRWKK 260
Query: 2084 GDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
D R G + + TL I+ D G Y C+A N VG + L V+
Sbjct: 261 DDADLPR------GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 314
Query: 2144 ANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALF-----SFDSRI 2198
PR V G T+ C G+P P + W+ + + LF +SR
Sbjct: 315 QFV----VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQ--NLLFPNQPQQPNSRC 368
Query: 2199 KVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDV----VMKPAKIEHKEENDHK 2254
V G L + ++ DAG Y+C A G +++V +P I + +
Sbjct: 369 SVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQT 428
Query: 2255 VFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEV 2314
+ G + C ATG P P ISW L +G GR R + GTL +
Sbjct: 429 LAVDGTALLKCKATGDPLPVISW-LKEGFTF---------PGRDPRATIQEQGTLQIKNL 478
Query: 2315 GMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVP 2359
+ + G YTC A + G+ + V + ATI +K Y +P
Sbjct: 479 RISDTGTYTCVATSSSGETSWSAVLDVTESGATI-SKNYDLSDLP 522
Score = 131 bits (330), Expect = 8e-30
Identities = 133/498 (26%), Positives = 199/498 (39%), Gaps = 58/498 (11%)
Query: 2356 VQVPYGDVVTVACEAKGEPMPKVTWLSP-----TNKVIPTSSEKYQIYQDGTLLIQKA-- 2408
V V G+ T+ C+A+G P P + W T+K P S + G+L +
Sbjct: 40 VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHR--MLLPSGSLFFLRIVH 97
Query: 2409 ---QRSDSGNYTCLVRNSAGED-RKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLI 2464
+ D G+Y C+ RN GE + + V + NP + + A G ++
Sbjct: 98 GRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV-----VVAAGEPAIL 152
Query: 2465 DCKA-EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNE 2523
+C+ G P P + W + + RI++ G G L I + RKSD+ C+ N
Sbjct: 153 ECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRG-GKLMISNTRKSDAGMYTCVGTNM 208
Query: 2524 GGEARLI-LQLTVLEPMEKPIF-HDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNG 2581
GE +LTV E +P F PI++ + + + C G P P++ W +
Sbjct: 209 VGERDSDPAELTVFE---RPTFLRRPINQVV--LEEEAVEFRCQVQGDPQPTVRWK-KDD 262
Query: 2582 TDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANK 2641
DL G R+ K D L I S D G Y C+A N G E +L V P+
Sbjct: 263 ADLPRG----RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV 318
Query: 2642 QYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGP----QTLGRVSLLDNGTLT 2697
+ + + + G T+ PC G Q W +L P Q R S+ G LT
Sbjct: 319 RPRDQI-VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 377
Query: 2698 VREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGN-------T 2750
+ D G Y+C+ T G + + V +T P P+I P N T
Sbjct: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDV---LTDRPPPIILQGPANQTLAVDGT 434
Query: 2751 VKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRF-LHPQGSLTIQHATQRDAGFYK 2809
L C A G P I+W LK G R + QG+L I++ D G Y
Sbjct: 435 ALLKCKATGDPLPVISW-------LKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 487
Query: 2810 CMAKNILGSDSKTTYIHV 2827
C+A + G S + + V
Sbjct: 488 CVATSSSGETSWSAVLDV 505
Score = 121 bits (304), Expect = 9e-27
Identities = 126/508 (24%), Positives = 188/508 (37%), Gaps = 34/508 (6%)
Query: 1950 PQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRV-WQTVSPVEGRITLHENR 2008
P + H DV V G+ + C A+G P P I W RV P R+ L
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 2009 TLSIK----EASFSDRGVYKCVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGL 2063
++ S D G Y CVA N G A S L VA L Q + + + G
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTD-VVVAAGE 148
Query: 2064 SIHIHC-TAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYEC 2122
+ C + P P++ W D +I + G L I N D+G Y C
Sbjct: 149 PAILECQPPRGHPEPTIYW-KKDKVRIDDKE----ERISIRGGKLMISNTRKSDAGMYTC 203
Query: 2123 VAANLVGSA-RRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR 2181
V N+VG +L V R P V ++ C GDP P + W+
Sbjct: 204 VGTNMVGERDSDPAELTVFERPTFLR----RPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
Query: 2182 LPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMK 2241
+ R + + TL +K D G Y+C+A N+VG + V
Sbjct: 260 KDDADLP------RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 313
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P + D V G + C G P P + W +GS + + + R
Sbjct: 314 PQFV--VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQ-KEGS--QNLLFPNQPQQPNSRC 368
Query: 2302 VVFNNGTLYFNEVGMREEGDYTCFAENQVG----KDEMRVRVKVVTAPATIRNKTYLAVQ 2357
V G L + + G Y C A G K ++ V + P I +
Sbjct: 369 SVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQT 428
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYT 2417
+ + C+A G+P+P ++WL P + I + GTL I+ + SD+G YT
Sbjct: 429 LAVDGTALLKCKATGDPLPVISWLK-EGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 487
Query: 2418 CLVRNSAGEDRKTVWIHVNVQPPKINGN 2445
C+ +S+GE + + V I+ N
Sbjct: 488 CVATSSSGETSWSAVLDVTESGATISKN 515
Score = 118 bits (295), Expect = 9e-26
Identities = 130/487 (26%), Positives = 194/487 (39%), Gaps = 46/487 (9%)
Query: 2242 PAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY 2301
P +EH +D V G ++C A G P P I W DG V ++D R+ R
Sbjct: 31 PRIVEHP--SDVIVSKGEPTTLNCKAEGRPTPTIEW-YKDGERV----ETDKDDPRSHR- 82
Query: 2302 VVFNNGTLYFNEV--GMR---EEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAV 2356
++ +G+L+F + G R +EG Y C A N +G+ R V + V
Sbjct: 83 MLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV 142
Query: 2357 QVPYGDVVTVACEA-KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGN 2415
V G+ + C+ +G P P + W +KV E+ + G L+I ++SD+G
Sbjct: 143 VVAAGEPAILECQPPRGHPEPTIYWKK--DKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
Query: 2416 YTCLVRNSAGE-DRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTP 2474
YTC+ N GE D + V +P + N + E C+ +G P P
Sbjct: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVE------FRCQVQGDPQP 254
Query: 2475 RVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLT 2534
V W + LP R + + +L I+ +D +C+A N G+ LT
Sbjct: 255 TVRWK-KDDADLPR----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT 309
Query: 2535 VLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL----QSGQQL 2590
V P P F ++I A G T++ C G P P++ W +L Q Q
Sbjct: 310 VRAP---PQFVVRPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPN 365
Query: 2591 QRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVG------LKPEANKQYH 2644
R G L I+ + DAG Y C A AG L+V P +
Sbjct: 366 SRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPA 425
Query: 2645 NLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVF 2704
N ++G L L C G SW L G G R ++ + GTL ++ +
Sbjct: 426 NQTLAVDGTAL-LKCKATGDPLPVISW-LKEGFTFPGRDP--RATIQEQGTLQIKNLRIS 481
Query: 2705 DRGTYVC 2711
D GTY C
Sbjct: 482 DTGTYTC 488
Score = 107 bits (267), Expect = 2e-22
Identities = 108/400 (27%), Positives = 166/400 (41%), Gaps = 50/400 (12%)
Query: 2439 PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEG--------------V 2484
PP+I +P+ + I + G ++CKAEG PTP + W + +G +
Sbjct: 30 PPRIVEHPSDV-----IVSKGEPTTLNCKAEGRPTPTIEW-YKDGERVETDKDDPRSHRM 83
Query: 2485 VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF 2544
+LP+ VHG S K D VC+ARN GEA ++ +E +
Sbjct: 84 LLPSGSLFFLRIVHGRRS-------KPDEGSYVCVARNYLGEA-----VSRNASLEVALL 131
Query: 2545 HDPISEK---ITAMAGHTISLNCSAA-GTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGM 2600
D + + AG L C G P P++ W ++ + +R + G
Sbjct: 132 RDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYW---KKDKVRIDDKEERISIRG-GK 187
Query: 2601 LHISGLSSVDAGAYRCVARNAAGHTER-LVSLKVGLKPEANKQYHNLVSIINGETLKLPC 2659
L IS DAG Y CV N G + L V +P ++ N V ++ E ++ C
Sbjct: 188 LMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQV-VLEEEAVEFRC 246
Query: 2660 TPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGP 2719
G Q W + + P+ GR + D+ TL +++ D GTY+C E G
Sbjct: 247 QVQGDPQPTVRWKKDDA---DLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK 301
Query: 2720 SVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGV 2779
S + V A PP+ P I + G TV C G P+ + W+ +L
Sbjct: 302 MEASATLTVRA-PPQFVVRPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPN 359
Query: 2780 QARLYGNR-FLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
Q + +R + P G LTI + + DAG+Y C A + GS
Sbjct: 360 QPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGS 399
Score = 92.4 bits (228), Expect = 6e-18
Identities = 73/236 (30%), Positives = 102/236 (43%), Gaps = 23/236 (9%)
Query: 1839 GGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTP 1898
G AS ++ PQ + + + T T FPCE G P+P V W K + L+ P
Sbjct: 300 GKMEASATLTVRAPPQFVVRPRDQIVAQGRTVT-FPCETKGNPQPAVFWQKEGSQNLLFP 358
Query: 1899 NTRIQ---RFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTV----QQPQ 1951
N Q R V G L I +Q D G Y+C A + G L VT + P
Sbjct: 359 NQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPP 418
Query: 1952 ILASHYQDVTVYLGDTIAMECLAKGTPAPQISWI-----FPDRRVWQTVSPVEGRITLHE 2006
I+ + T+ + T ++C A G P P ISW+ FP R + R T+ E
Sbjct: 419 IILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGR---------DPRATIQE 469
Query: 2007 NRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQE-KLENISLPP 2061
TL IK SD G Y CVA++++G S + L V I + L ++ PP
Sbjct: 470 QGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPP 525
Score = 69.3 bits (168), Expect = 5e-11
Identities = 51/202 (25%), Positives = 84/202 (41%), Gaps = 27/202 (13%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMD--DPDSKFSILSSGWLRIKS 544
RDQ V +G C K + P++FW L P P+S+ S+ +G L I +
Sbjct: 321 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 380
Query: 545 MEPSDSGLYQCIA-------------QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP 591
++ SD+G Y C A +V D + +++Q P+ Q D +
Sbjct: 381 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL---- 436
Query: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRC 651
L C A P +SW+ + + GTL I +++SD+G Y C
Sbjct: 437 -----LKCKATGDPLPVISWL---KEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTC 488
Query: 652 VAVNQQGADHFTVGITVTKKGS 673
VA + G ++ + VT+ G+
Sbjct: 489 VATSSSGETSWSAVLDVTESGA 510
Score = 65.5 bits (158), Expect = 7e-10
Identities = 48/181 (26%), Positives = 74/181 (40%), Gaps = 23/181 (12%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
+Q VLE + C V+ P++ W D + P ++ I LRIK
Sbjct: 233 NQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL-------PRGRYDIKDDYTLRIKKTMS 285
Query: 548 SDSGLYQCIAQVR-DEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPE 606
+D G Y CIA+ R +M+ + P +D + G +VT PC P+
Sbjct: 286 TDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVA---QGRTVTFPCETKGNPQ 342
Query: 607 AHLSW--------ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ W + PN+ S + P G L+I +Q SD+GYY C A+ G
Sbjct: 343 PAVFWQKEGSQNLLFPNQ----PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 398
Query: 659 A 659
+
Sbjct: 399 S 399
Score = 50.4 bits (119), Expect = 2e-05
Identities = 54/182 (29%), Positives = 73/182 (40%), Gaps = 21/182 (11%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG---WLRIKS 544
D V +G P L+C + +P+I W DG ++ DDP S +L SG +LRI
Sbjct: 39 DVIVSKGEPTTLNCKAEGRPTPTIEW-YKDGERVETDKDDPRSHRMLLPSGSLFFLRIVH 97
Query: 545 MEPS--DSGLYQCIAQVRDEMDRMVYR-----VLVQSPSTQPAEKDTVTIGKNPGESVTL 597
S D G Y C+A R+ + V R V + + D V GE L
Sbjct: 98 GRRSKPDEGSYVCVA--RNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA---GEPAIL 152
Query: 598 PCN-ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
C PE + W RI + S + G L I + SD+G Y CV N
Sbjct: 153 ECQPPRGHPEPTIYWKKDKVRIDDKEERIS----IRGGKLMISNTRKSDAGMYTCVGTNM 208
Query: 657 QG 658
G
Sbjct: 209 VG 210
Score = 46.2 bits (108), Expect = 5e-04
Identities = 44/184 (23%), Positives = 72/184 (39%), Gaps = 17/184 (9%)
Query: 488 DQTVLEGGPCQLSCNV-KASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
D V G P L C + P+I+W K +DD + + SI G L I +
Sbjct: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKD-----KVRIDDKEERISI-RGGKLMISNTR 194
Query: 547 PSDSGLYQCIA--QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
SD+G+Y C+ V + + + P+ + V + + E+V C
Sbjct: 195 KSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEE---EAVEFRCQVQGD 251
Query: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
P+ + W + + + Y TL I K +D G Y C+A N+ G +
Sbjct: 252 PQPTVRWKKDDADLPRGRYDIKDDY-----TLRIKKTMSTDEGTYMCIAENRVGKMEASA 306
Query: 665 GITV 668
+TV
Sbjct: 307 TLTV 310
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
sapiens]
Length = 1014
Score = 151 bits (382), Expect = 8e-36
Identities = 154/599 (25%), Positives = 228/599 (38%), Gaps = 65/599 (10%)
Query: 1814 SSISFIT-SSVQSSGSFHQSSSKFFAGGPPASKFWSLGEK-----PQILTKSPQTVSVTA 1867
SS+SF +Q SG+F + G S S K P +L +
Sbjct: 83 SSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQP 142
Query: 1868 ETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYM 1927
+T C G P+P W + T + + K L +R + G Y
Sbjct: 143 QTQVTLRCHIDGHPRPTYQWFRDGTPL---SDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
Query: 1928 CTASNLHG--LDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWI 1985
C A + G LS+ + + QDV V + C P P + W+
Sbjct: 200 CCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
Query: 1986 FPDRRVWQTVS--PVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS-LAIRLHV 2042
F D S P R T+ N +L + + + G+Y+C+ G L LH+
Sbjct: 260 FEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHL 319
Query: 2043 AAL-------PPVIHQEKLENIS-LPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQF 2094
A + P V E ++ LPP K P PSV W G ++
Sbjct: 320 AEIEDMPLFEPRVFTAGSEERVTCLPP----------KGLPEPSVWWEHA-GVRLPT--- 365
Query: 2095 LHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPR 2154
HG ++ L + N+A D+G Y C AANL G R+ V + V + + P+
Sbjct: 366 -HGRVYQ-KGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLK----KPQ 419
Query: 2155 RTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDK 2214
+ + G LDC P P ++W L S DSR +VF NGTL + SV
Sbjct: 420 DSQLEEGKPGYLDCLTQATPKPTVVWYRNQM-----LISEDSRFEVFKNGTLRINSVEVY 474
Query: 2215 DAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPE 2274
D Y C++ G +V V+ K K + + + + V C ATG P
Sbjct: 475 DGTWYRCMSSTPAGSIEAQARVQVLEK-LKFTPPPQPQQCMEFDKEATVPCSATGREKPT 533
Query: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
I W DGS + +V N GTL+F V + G+YTC A N + +
Sbjct: 534 IKWERADGSSL-------------PEWVTDNAGTLHFARVTRDDAGNYTCIASNG-PQGQ 579
Query: 2335 MRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSE 2393
+R V++ A V G + CEA+G+P P + W +K +P SE
Sbjct: 580 IRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW---KDKPVPEESE 635
Score = 139 bits (351), Expect = 3e-32
Identities = 137/569 (24%), Positives = 226/569 (39%), Gaps = 49/569 (8%)
Query: 2019 DRGVYKCVASN-----AAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKA 2073
D G ++CVA + A + + + + PV+ + + P + + C
Sbjct: 95 DSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDG 154
Query: 2074 APLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARR 2133
P P+ +W DGT + Q H N TL R P+ SG Y C A + G A
Sbjct: 155 HPRPTYQW-FRDGTPLSDGQSNHTVSSKERNLTL--RPAGPEHSGLYSCCAHSAFGQACS 211
Query: 2134 TVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMID--AL 2191
+ + A + +P+ V C S P P + W + I +
Sbjct: 212 SQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSR 271
Query: 2192 FSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEEN 2251
R VFANG+L++ V ++AG Y C+ + + G ++ + + A+IE
Sbjct: 272 PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIIL---EATLHLAEIEDMPLF 328
Query: 2252 DHKVFYGG-DLKVDCVAT-GLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG-T 2308
+ +VF G + +V C+ GLP P + W L + GR V+ G
Sbjct: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRL--------PTHGR-----VYQKGHE 375
Query: 2309 LYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVAC 2368
L + + G YTC A N G+ V + V T P+ ++ Q+ G + C
Sbjct: 376 LVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQ--DSQLEEGKPGYLDC 433
Query: 2369 EAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDR 2428
+ P P V W N+++ + +++++++GTL I + D Y C+ AG
Sbjct: 434 LTQATPKPTVVWYR--NQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIE 491
Query: 2429 KTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPA 2488
+ V ++ K P P ++ + C A G P + W +G LP
Sbjct: 492 AQARVQV-LEKLKFTPPPQP----QQCMEFDKEATVPCSATGREKPTIKWERADGSSLPE 546
Query: 2489 PYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARN-EGGEARLILQLTVLEPMEKPIFHDP 2547
N T+H + + D+ C+A N G+ R +QLTV + + +P
Sbjct: 547 WVTDNAGTLH------FARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKV--EP 598
Query: 2548 ISEKITAMAGHTISLNCSAAGTPTPSLVW 2576
E+ T GHT L C A G P P + W
Sbjct: 599 --ERTTVYQGHTALLQCEAQGDPKPLIQW 625
Score = 101 bits (251), Expect = 1e-20
Identities = 115/517 (22%), Positives = 191/517 (36%), Gaps = 53/517 (10%)
Query: 2316 MREEGDYTCFAENQVGKDEMR-----VRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEA 2370
+++ G + C A + V +E R +K + A + ++ VT+ C
Sbjct: 93 LQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHI 152
Query: 2371 KGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKT 2430
G P P W + S ++ L ++ A SG Y+C ++ G+ +
Sbjct: 153 DGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSS 212
Query: 2431 VWIHVNVQPP---KINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLP 2487
+++ ++ P + R A + C+ P P + W F + +
Sbjct: 213 QNFTLSIADESFARVVLAPQDVVVARYEEA-----MFHCQFSAQPPPSLQWLFEDETPIT 267
Query: 2488 ---APYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLI---LQLTVLEPMEK 2541
P + R TV NGSL + +R ++ C+ + + G ++ L L +E M
Sbjct: 268 NRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDM-- 325
Query: 2542 PIFHDPISEKITAMAGHTISLNC-SAAGTPTPSLVWVLPNGTDLQSGQQLQ---RFYHKA 2597
P+ E AG + C G P PS+ W +G +L R Y K
Sbjct: 326 -----PLFEPRVFTAGSEERVTCLPPKGLPEPSVWWE-------HAGVRLPTHGRVYQKG 373
Query: 2598 DGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKL 2657
++ ++ ++ DAG Y C A N AG + V++ V P K+ + + G+ L
Sbjct: 374 HELV-LANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD-SQLEEGKPGYL 431
Query: 2658 PCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEY 2717
C + W + E R + NGTL + V+D Y C T
Sbjct: 432 DCLTQATPKPTVVWYRNQMLISED----SRFEVFKNGTLRINSVEVYDGTWYRCMSSTPA 487
Query: 2718 GPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKA 2777
G S+ + + + + T P P + C A G K I WE D S L
Sbjct: 488 G-SIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPE 546
Query: 2778 GVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKN 2814
V G+L T+ DAG Y C+A N
Sbjct: 547 WVTDN---------AGTLHFARVTRDDAGNYTCIASN 574
Score = 100 bits (249), Expect = 2e-20
Identities = 143/648 (22%), Positives = 246/648 (37%), Gaps = 78/648 (12%)
Query: 2153 PRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVT 2212
P D G L C + W L + D + FA G+ + +
Sbjct: 38 PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTE-------RRFAQGSSLSFAAV 90
Query: 2213 DK--DAGDYLCVARNKV-GDDYVVLKVDVVMK-----PAKIEHKEENDHKVFYGGDLKVD 2264
D+ D+G + CVAR+ V G++ +K P ++H ++ ++ + +
Sbjct: 91 DRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPA-SEAEIQPQTQVTLR 149
Query: 2265 CVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTC 2324
C G P P W DG+ + S G++ V L G G Y+C
Sbjct: 150 CHIDGHPRPTYQW-FRDGTPL--------SDGQSNHTVSSKERNLTLRPAGPEHSGLYSC 200
Query: 2325 FAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVA-------CEAKGEPMPK 2377
A + G+ +I ++++ V + DVV C+ +P P
Sbjct: 201 CAHSAFGQ-----ACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPS 255
Query: 2378 VTWLSP-----TNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVW 2432
+ WL TN+ P + ++ +G+LL+ + + ++G Y C+ + G +
Sbjct: 256 LQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPP---II 312
Query: 2433 IHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYG 2492
+ + +I P + R AG ++ +G+P P V W GV LP
Sbjct: 313 LEATLHLAEIEDMP--LFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHA-GVRLPTH--- 366
Query: 2493 NRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEP---MEKPIFHDPIS 2549
R+ G+ L + ++ +SD+ C A N G+ R + +TV ++KP D
Sbjct: 367 GRVYQKGH-ELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKP--QDSQL 423
Query: 2550 EKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSV 2609
E+ G L+C TP P++VW N + + + F +G L I+ +
Sbjct: 424 EE-----GKPGYLDCLTQATPKPTVVWYR-NQMLISEDSRFEVF---KNGTLRINSVEVY 474
Query: 2610 DAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRF 2669
D YRC++ AG E ++V K + + + +PC+ G +
Sbjct: 475 DGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTI 534
Query: 2670 SWTLPNGMHLEGPQTLGRVSLLDN-GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIV 2728
W +G L T DN GTL + D G Y C + + +
Sbjct: 535 KWERADGSSLPEWVT-------DNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLT 587
Query: 2729 IAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWE---LPDKS 2773
+A EP + G+T L C A G PK I W+ +P++S
Sbjct: 588 VAVFITFKVEPERTTVYQ-GHTALLQCEAQGDPKPLIQWKDKPVPEES 634
Score = 63.5 bits (153), Expect = 3e-09
Identities = 94/407 (23%), Positives = 152/407 (37%), Gaps = 40/407 (9%)
Query: 2440 PKINGNPNPITTVREI----AAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRI 2495
P + G I +++ A G R L+ C+ E V W AP
Sbjct: 23 PLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDG-----APVQDTER 77
Query: 2496 TVHGNGSLDIRSL-RKSDSVQLVCMARNE--GGEARLILQLTVLEPMEK-PIFHDPISEK 2551
SL ++ R DS C+AR++ G EAR ++ +E P+ + +
Sbjct: 78 RFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASE 137
Query: 2552 ITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDA 2611
++L C G P P+ W +GT L GQ K + L + +
Sbjct: 138 AEIQPQTQVTLRCHIDGHPRPTYQW-FRDGTPLSDGQSNHTVSSK-ERNLTLRPAGPEHS 195
Query: 2612 GAYRCVARNAAGHTERLVSLKVGLKPEANKQY---HNLVSIINGETLKLPCT----PPGA 2664
G Y C A +A G + + + E+ + V + E C PP +
Sbjct: 196 GLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPS 255
Query: 2665 GQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSI 2724
Q F P + P L R ++ NG+L + + + G Y C + + GP
Sbjct: 256 LQWLFEDETPI-TNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGP----- 309
Query: 2725 PVIVIAYPPRITSEPTPVIYTR---PGNTVKLNCMA-MGIPKADITWELPDKSHLKAGVQ 2780
P+I+ A E P+ R G+ ++ C+ G+P+ + WE AGV+
Sbjct: 310 PIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWE-------HAGVR 362
Query: 2781 ARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+G R L + + + DAG Y C A N+ G + I V
Sbjct: 363 LPTHG-RVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITV 408
Score = 59.3 bits (142), Expect = 5e-08
Identities = 94/461 (20%), Positives = 169/461 (36%), Gaps = 34/461 (7%)
Query: 2368 CEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQR-SDSGNYTCLVRNSA-G 2425
CE + V WL P + + Q +L R DSG + C+ R+ G
Sbjct: 53 CEVEAPGPVHVYWLLDG---APVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTG 109
Query: 2426 EDRKTVWIHVNVQ----PPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFP 2481
E+ ++ N++ P + +P ++ ++ + C +G P P W F
Sbjct: 110 EEARSANASFNIKWIEAGPVVLKHPASEAEIQP----QTQVTLRCHIDGHPRPTYQW-FR 164
Query: 2482 EGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEK 2541
+G L + N +L +R S C A + G+A T L ++
Sbjct: 165 DGTPL-SDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFT-LSIADE 222
Query: 2542 PIFHDPISEKITAMAGHTISL-NCSAAGTPTPSLVWVLPNGTDLQSGQQ---LQRFYHKA 2597
++ + +A + ++ +C + P PSL W+ + T + + + L+R A
Sbjct: 223 SFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFA 282
Query: 2598 DGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKL 2657
+G L ++ + +AG YRC+ + G L + + E + V E ++
Sbjct: 283 NGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEE-RV 341
Query: 2658 PCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEY 2717
C PP W G+ L T GRV + L + + D G Y C
Sbjct: 342 TCLPPKGLPEPSVWWEHAGVRLP---THGRVYQKGH-ELVLANIAESDAGVYTCHAANLA 397
Query: 2718 GPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKA 2777
G + + V P + + G L+C+ PK + W ++ +
Sbjct: 398 GQRRQDVNITVATVPSWLKKPQDSQL--EEGKPGYLDCLTQATPKPTVVWY---RNQMLI 452
Query: 2778 GVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
+R + G+L I D +Y+CM+ GS
Sbjct: 453 SEDSRFE----VFKNGTLRINSVEVYDGTWYRCMSSTPAGS 489
Score = 53.9 bits (128), Expect = 2e-06
Identities = 47/188 (25%), Positives = 78/188 (41%), Gaps = 24/188 (12%)
Query: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546
+D + EG P L C +A+ P++ W I + DS+F + +G LRI S+E
Sbjct: 419 QDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISE------DSRFEVFKNGTLRINSVE 472
Query: 547 PSDSGLYQCIA-----QVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNA 601
D Y+C++ + + V L +P QP + + T+PC+A
Sbjct: 473 VYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQ------CMEFDKEATVPCSA 526
Query: 602 LAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVN-QQGAD 660
+ + W + + + + GTL +V D+G Y C+A N QG
Sbjct: 527 TGREKPTIKWERADGSSLPEWVTDN------AGTLHFARVTRDDAGNYTCIASNGPQGQI 580
Query: 661 HFTVGITV 668
V +TV
Sbjct: 581 RAHVQLTV 588
Score = 43.5 bits (101), Expect = 0.003
Identities = 38/168 (22%), Positives = 66/168 (39%), Gaps = 15/168 (8%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW-LRIKSMEPSDSGLYQCIA 557
L C++ P+ W DG+ P+ D S ++ S L ++ P SGLY C A
Sbjct: 148 LRCHIDGHPRPTYQW-FRDGT----PLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCA 202
Query: 558 QVRD----EMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWIL 613
+ +S + V + + E C A P L W+
Sbjct: 203 HSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARY--EEAMFHCQFSAQPPPSLQWLF 260
Query: 614 PNRRIINDLANTSHVY---MLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ I + + H+ + NG+L + +V+ ++G YRC+ Q+G
Sbjct: 261 EDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
Score = 42.0 bits (97), Expect = 0.009
Identities = 49/190 (25%), Positives = 78/190 (41%), Gaps = 23/190 (12%)
Query: 489 QTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP- 547
Q L+G L C V+A ++W+L DG AP+ D + +F+ SS L +++
Sbjct: 41 QDALQGRRALLRCEVEAPGPVHVYWLL-DG----APVQDTERRFAQGSS--LSFAAVDRL 93
Query: 548 SDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGK-------NPGESVTLPCN 600
DSG +QC+A RD++ R S + + E V + P VTL C+
Sbjct: 94 QDSGTFQCVA--RDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCH 151
Query: 601 ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG-- 658
P W + + +N H L++ SG Y C A + G
Sbjct: 152 IDGHPRPTYQWFRDGTPLSDGQSN--HTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQA 209
Query: 659 --ADHFTVGI 666
+ +FT+ I
Sbjct: 210 CSSQNFTLSI 219
Score = 41.6 bits (96), Expect = 0.011
Identities = 52/216 (24%), Positives = 82/216 (37%), Gaps = 18/216 (8%)
Query: 462 TISTKDTRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSIL 521
T+S D AR V++ P +D V C A PS+ W+ D + +
Sbjct: 216 TLSIADESFAR----VVLAP-----QDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPI 266
Query: 522 KAPMDDPD-SKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVL-VQSPSTQP 579
P + ++ ++G L + + P ++G+Y+CI Q + ++ L + P
Sbjct: 267 TNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP 326
Query: 580 AEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIP 639
+ V + LP L PE + W R L VY + L +
Sbjct: 327 LFEPRVFTAGSEERVTCLPPKGL--PEPSVWWEHAGVR----LPTHGRVYQKGH-ELVLA 379
Query: 640 KVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGL 675
+ SD+G Y C A N G V ITV S L
Sbjct: 380 NIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWL 415
Score = 40.8 bits (94), Expect = 0.019
Identities = 36/133 (27%), Positives = 55/133 (41%), Gaps = 8/133 (6%)
Query: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQS-PSTQPAEKDTVTIGKNPGESVTLP 598
L + ++ SD+G+Y C A R + V + PS +D+ PG L
Sbjct: 376 LVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGY---LD 432
Query: 599 CNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
C A P+ + W I D S + NGTL I V+V D +YRC++ G
Sbjct: 433 CLTQATPKPTVVWYRNQMLISED----SRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAG 488
Query: 659 ADHFTVGITVTKK 671
+ + V +K
Sbjct: 489 SIEAQARVQVLEK 501
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 150 bits (380), Expect = 1e-35
Identities = 155/576 (26%), Positives = 232/576 (40%), Gaps = 56/576 (9%)
Query: 2065 IHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAP-KDSGRYECV 2123
+ ++C + P+PS RW L +GT+I +L +GT I N + KDSG Y+C+
Sbjct: 119 VALNCEVRGNPVPSYRW-LRNGTEIDLESDYRYSLI---DGTFIISNPSEAKDSGHYQCL 174
Query: 2124 AANLVGSA---RRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILW 2180
A N VGS T+Q A +G + VR G + L CS P I++
Sbjct: 175 ATNTVGSILSREATLQF-----AYLGNFSGRTRSAVSVREGQGVVLMCSPPPHS-PEIIY 228
Query: 2181 RLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVV------- 2233
+ R G L + V D G Y+C+ +N V + V+
Sbjct: 229 SWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLT 288
Query: 2234 LKVDVVMKP--AKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQS 2291
L+ D VM KIE G +K++C A G P P I+W +G +
Sbjct: 289 LRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYI------- 341
Query: 2292 DDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNK 2351
S R ++ + L V + + G Y C AEN GK+ R +++V T P +
Sbjct: 342 -PSKARLRK----SQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKL 396
Query: 2352 TYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRS 2411
Q+ G + C+A G+P P WL +P S + +G L+I +S
Sbjct: 397 N--DTQLDSGSPLRWECKATGKPRPTYRWLK---NGVPLSPQSRVEMVNGVLMIHNVNQS 451
Query: 2412 DSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGI 2471
D+G Y CL N G + + + P N T I +I+CK +G
Sbjct: 452 DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTI---IVTKDQEVVIECKPQGS 508
Query: 2472 PTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLIL 2531
P P + W + V RI + +GSL I + KSD + VC N G A +I
Sbjct: 509 PKPTISWKKGDRAVRE----NKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIA 564
Query: 2532 QLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAA--GTPTPSLVWVL---PNGTDLQS 2586
L+V EP I P ++T G +I LNC A + + W L P + +
Sbjct: 565 SLSVKEPTR--IELTPKRTELT--VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEG 620
Query: 2587 GQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAA 2622
G + L I + + AG Y C + A
Sbjct: 621 GHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTA 656
Score = 140 bits (354), Expect = 1e-32
Identities = 127/468 (27%), Positives = 199/468 (42%), Gaps = 40/468 (8%)
Query: 2364 VTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQK-AQRSDSGNYTCLVRN 2422
V + CE +G P+P WL ++ S +Y + DGT +I ++ DSG+Y CL N
Sbjct: 119 VALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI-DGTFIISNPSEAKDSGHYQCLATN 177
Query: 2423 SAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVL--WAF 2480
+ G +G +VRE G ++ C +P ++ W F
Sbjct: 178 TVGSILSREATLQFAYLGNFSGRTRSAVSVRE----GQGVVLMCSPPP-HSPEIIYSWVF 232
Query: 2481 PEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVL---- 2536
E A R G+L I ++ SD +C+ +N AR++ T L
Sbjct: 233 NEFPSFVAE-DSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRN 291
Query: 2537 -----EPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQ 2591
E K H P + +TA G T+ + C A G P P++ W+ NG + S +L+
Sbjct: 292 DGVMGEYEPKIEVHFPFT--VTAAKGTTVKMECFALGNPVPTITWMKVNGY-IPSKARLR 348
Query: 2592 RFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIIN 2651
K+ +L I + DAG Y C A N+ G L+V P ++ N + +
Sbjct: 349 ----KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKL-NDTQLDS 403
Query: 2652 GETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVC 2711
G L+ C G + + W L NG+ L PQ+ RV ++ NG L + + D G Y C
Sbjct: 404 GSPLRWECKATGKPRPTYRW-LKNGVPL-SPQS--RVEMV-NGVLMIHNVNQSDAGMYQC 458
Query: 2712 RMETEYGPSVTSIPVIVIAYPPRIT-SEPTPVIYTRPGNTVKLNCMAMGIPKADITWELP 2770
E +YG S + ++A P ++ I V + C G PK I+W+
Sbjct: 459 LAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKG 518
Query: 2771 DKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
D++ R + P GSL I +A++ D G Y C +N+ GS
Sbjct: 519 DRA-------VRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGS 559
Score = 129 bits (324), Expect = 4e-29
Identities = 124/552 (22%), Positives = 223/552 (40%), Gaps = 57/552 (10%)
Query: 1858 KSPQTVSVTAETDTVFPCEATG-KPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIR 1916
++ VSV V C P+ +W + + ++R RF + G L I
Sbjct: 200 RTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSR--RFISQETGNLYIS 257
Query: 1917 KVQVQDRGQYMCTASNLHGLDRMVVLLS-VTVQQPQILASHYQDVTVYL--------GDT 1967
KVQ D G Y+C N R++ + +T++ ++ + + V+ G T
Sbjct: 258 KVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTT 317
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVA 2027
+ MEC A G P P I+W+ + + P + R+ L I D G+Y+C A
Sbjct: 318 VKMECFALGNPVPTITWMKVNGYI-----PSKARLR-KSQAVLEIPNVQLDDAGIYECRA 371
Query: 2028 SNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGT 2087
N+ G +S +L V P + EKL + L G + C A P P+ RW L +G
Sbjct: 372 ENSRGKNSFRGQLQVYTYPHWV--EKLNDTQLDSGSPLRWECKATGKPRPTYRW-LKNGV 428
Query: 2088 QIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANAR 2147
+ P + NG L I N+ D+G Y+C+A N G+ + +L + +A
Sbjct: 429 PLSPQSRVE-----MVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFA 483
Query: 2148 ITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLV 2207
+ + V + ++C G P P I W+ + + + + RI + +G+L
Sbjct: 484 LNQLK-KTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRE-----NKRIAILPDGSLR 537
Query: 2208 VKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVA 2267
+ + + D G Y+C N G ++ + V +P +IE + ++ G + ++C A
Sbjct: 538 ILNASKSDEGKYVCRGENVFGSAEIIASLS-VKEPTRIELTPKRT-ELTVGESIVLNCKA 595
Query: 2268 TGLPNPEIS--WSLPDGSLVNSFMQSDDSGGRTKRY-VVFNNGTLYFNEVGMREEGDYTC 2324
+ +++ W+L + ++ GG + ++ L + + G Y C
Sbjct: 596 IHDASLDVTFYWTLKGQPI-----DFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGC 650
Query: 2325 FAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPT 2384
+V T ++ ++ L V+ P G V E E ++W
Sbjct: 651 ---------------RVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAA 695
Query: 2385 NKVIPTSSEKYQ 2396
+ P SS Q
Sbjct: 696 DNHSPISSYNLQ 707
Score = 126 bits (317), Expect = 3e-28
Identities = 126/512 (24%), Positives = 204/512 (39%), Gaps = 46/512 (8%)
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVA 2027
+A+ C +G P P W+ R + + R +L + + + D G Y+C+A
Sbjct: 119 VALNCEVRGNPVPSYRWL---RNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLA 175
Query: 2028 SNAAGAD-SLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKA-APLPSVRWVLGD 2085
+N G+ S L A L + + +S+ G + + C+ +P WV +
Sbjct: 176 TNTVGSILSREATLQFAYLGNFSGRTR-SAVSVREGQGVVLMCSPPPHSPEIIYSWVFNE 234
Query: 2086 GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAAN 2145
G LYI + D G Y C+ N V +A R + N
Sbjct: 235 FPSFVAED--SRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNA-RVLSPPTPLTLRN 291
Query: 2146 ARITGTSPRRTDVRY--------GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSR 2197
+ G + +V + G T+K++C A G+P P I W ++ +R
Sbjct: 292 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITW-----MKVNGYIPSKAR 346
Query: 2198 IKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFY 2257
++ + L + +V DAG Y C A N G + ++ V P +E + ND ++
Sbjct: 347 LRK-SQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVE--KLNDTQLDS 403
Query: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
G L+ +C ATG P P W L N S S V NG L + V
Sbjct: 404 GSPLRWECKATGKPRPTYRW------LKNGVPLSPQS------RVEMVNGVLMIHNVNQS 451
Query: 2318 EEGDYTCFAENQVGKDEMRVRVKVV-TAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMP 2376
+ G Y C AEN+ G +K++ +AP N+ + V V + C+ +G P P
Sbjct: 452 DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP 511
Query: 2377 KVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVN 2436
++W V +++ I DG+L I A +SD G Y C N G + V
Sbjct: 512 TISWKKGDRAV--RENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVK 569
Query: 2437 VQPPKINGNPNPITTVREIAAGGSRKLIDCKA 2468
+P +I +T R G +++CKA
Sbjct: 570 -EPTRIE-----LTPKRTELTVGESIVLNCKA 595
Score = 126 bits (317), Expect = 3e-28
Identities = 149/594 (25%), Positives = 240/594 (40%), Gaps = 69/594 (11%)
Query: 2166 LDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTD-KDAGDYLCVAR 2224
L+C G+P P W L + ID D R + +GT ++ + ++ KD+G Y C+A
Sbjct: 121 LNCEVRGNPVPSYRW-LRNGTEID--LESDYRYSLI-DGTFIISNPSEAKDSGHYQCLAT 176
Query: 2225 NKVGDDYVVLKVDVVMKPAKIEH---KEENDHKVFYGGDLKVDCVATGLPNPEISWSLPD 2281
N VG +L + ++ A + + + + V G + + C + +PEI +S
Sbjct: 177 NTVGS---ILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMC-SPPPHSPEIIYSWVF 232
Query: 2282 GSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKV 2341
SF+ D ++R++ G LY ++V + G Y C +N V RV
Sbjct: 233 NEFP-SFVAED-----SRRFISQETGNLYISKVQTSDVGSYICLVKNTV----TNARVLS 282
Query: 2342 VTAPATIRN-------KTYLAVQVPY------GDVVTVACEAKGEPMPKVTWLSPTNKVI 2388
P T+RN + + V P+ G V + C A G P+P +TW+ N I
Sbjct: 283 PPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMK-VNGYI 341
Query: 2389 PTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP---PKINGN 2445
P+ + + L I Q D+G Y C NS G++ + V P K+N
Sbjct: 342 PSKARLRK--SQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDT 399
Query: 2446 PNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDI 2505
GS +CKA G P P W GV L + NG L I
Sbjct: 400 Q---------LDSGSPLRWECKATGKPRPTYRW-LKNGVPLSPQSRVEMV----NGVLMI 445
Query: 2506 RSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH-DPISEKITAMAGHTISLNC 2564
++ +SD+ C+A N+ G +L +L P F + + + I + + C
Sbjct: 446 HNVNQSDAGMYQCLAENKYGAIYASAELKILA--SAPTFALNQLKKTIIVTKDQEVVIEC 503
Query: 2565 SAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGH 2624
G+P P++ W + ++ ++ +R DG L I S D G Y C N G
Sbjct: 504 KPQGSPKPTISWKKGD----RAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGS 559
Query: 2625 TERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTP--PGAGQGRFSWTL---PNGMHL 2679
E + SL V +P + + GE++ L C + F WTL P
Sbjct: 560 AEIIASLSV-KEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEE 618
Query: 2680 EGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPP 2733
EG + + L +R + G Y CR++T SV+ +++ PP
Sbjct: 619 EGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTT-ADSVSDEAELLVRGPP 671
Score = 116 bits (291), Expect = 3e-25
Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 25/327 (7%)
Query: 1849 LGE-KPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEV 1907
+GE +P+I P TV+ T C A G P P +TW KV+ + R+++ +
Sbjct: 295 MGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVN--GYIPSKARLRKSQA 352
Query: 1908 LKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDT 1967
+ L I VQ+ D G Y C A N G + L V + D + G
Sbjct: 353 V----LEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV--EKLNDTQLDSGSP 406
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVA 2027
+ EC A G P P W+ + +SP + R+ + N L I + SD G+Y+C+A
Sbjct: 407 LRWECKATGKPRPTYRWL----KNGVPLSP-QSRVEM-VNGVLMIHNVNQSDAGMYQCLA 460
Query: 2028 SNAAGADSLAIRLHVAALPPVIHQEKL-ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDG 2086
N GA + L + A P +L + I + + I C + +P P++ W GD
Sbjct: 461 ENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGD- 519
Query: 2087 TQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANA 2146
+R ++ + + P+G+L I N + D G+Y C N+ GSA L+V+
Sbjct: 520 RAVRENK----RIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEP---T 572
Query: 2147 RITGTSPRRTDVRYGGTLKLDCSASGD 2173
RI T P+RT++ G ++ L+C A D
Sbjct: 573 RIELT-PKRTELTVGESIVLNCKAIHD 598
Score = 110 bits (276), Expect = 2e-23
Identities = 141/604 (23%), Positives = 232/604 (38%), Gaps = 81/604 (13%)
Query: 1855 ILTKSPQTVSVTAETD---TVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG 1911
+ + P + ++D CE G P P W + T + + R L +G
Sbjct: 100 VFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYS----LIDG 155
Query: 1912 TLVIRKV-QVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQI---LASHYQDVTVYLGDT 1967
T +I + +D G Y C A+N G ++ T+Q + V+V G
Sbjct: 156 TFIISNPSEAKDSGHYQCLATNTVG---SILSREATLQFAYLGNFSGRTRSAVSVREGQG 212
Query: 1968 IAMECLAKGTPAPQI--SWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKC 2025
+ + C + +P+I SW+F + + V+ R E L I + SD G Y C
Sbjct: 213 VVLMC-SPPPHSPEIIYSWVFNEFPSF--VAEDSRRFISQETGNLYISKVQTSDVGSYIC 269
Query: 2026 VASNA-------AGADSLAIRLH--VAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPL 2076
+ N + L +R + P I ++ G ++ + C A P+
Sbjct: 270 LVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPV 329
Query: 2077 PSVRWVLGDG-----TQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSA 2131
P++ W+ +G ++R SQ L I N+ D+G YEC A N G
Sbjct: 330 PTITWMKVNGYIPSKARLRKSQ-----------AVLEIPNVQLDDAGIYECRAENSRGKN 378
Query: 2132 RRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDAL 2191
QL V T + G L+ +C A+G P P W +
Sbjct: 379 SFRGQLQVYTYPHWVE----KLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPL---- 430
Query: 2192 FSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMK-PAKIEHKEE 2250
S SR+++ NG L++ +V DAG Y C+A NK G Y ++ ++ P ++ +
Sbjct: 431 -SPQSRVEM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLK 488
Query: 2251 NDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLY 2310
V ++ ++C G P P ISW + D + KR + +G+L
Sbjct: 489 KTIIVTKDQEVVIECKPQGSPKPTISWK-----------KGDRAVRENKRIAILPDGSLR 537
Query: 2311 FNEVGMREEGDYTCFAENQVGKDEM--RVRVKVVTAPATIRNKTYLAVQVPYGDVVTVAC 2368
+EG Y C EN G E+ + VK T +T L V G+ + + C
Sbjct: 538 ILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTV----GESIVLNC 593
Query: 2369 EAKGEPMPKVTWLSPTNKVIPTSSEKYQIY--------QDGTLLIQKAQRSDSGNYTCLV 2420
+A + VT+ T K P E+ + L+I+ +G Y C V
Sbjct: 594 KAIHDASLDVTFYW-TLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRV 652
Query: 2421 RNSA 2424
+ +A
Sbjct: 653 QTTA 656
Score = 88.6 bits (218), Expect = 8e-17
Identities = 77/286 (26%), Positives = 121/286 (42%), Gaps = 34/286 (11%)
Query: 2560 ISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSV-DAGAYRCVA 2618
++LNC G P PS W L NGT++ + Y DG IS S D+G Y+C+A
Sbjct: 119 VALNCEVRGNPVPSYRW-LRNGTEIDLESDYR--YSLIDGTFIISNPSEAKDSGHYQCLA 175
Query: 2619 RNAAGHT-ERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPG-AGQGRFSWTLPNG 2676
N G R +L+ + + + VS+ G+ + L C+PP + + +SW
Sbjct: 176 TNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF 235
Query: 2677 MHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRME-TEYGPSVTSIPV--------I 2727
+ +S + G L + + D G+Y+C ++ T V S P +
Sbjct: 236 PSFVAEDSRRFISQ-ETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGV 294
Query: 2728 VIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWE-----LPDKSHLKAGVQAR 2782
+ Y P+I + G TVK+ C A+G P ITW +P K+ L+
Sbjct: 295 MGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKS---- 350
Query: 2783 LYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHVF 2828
Q L I + DAG Y+C A+N G +S + V+
Sbjct: 351 ---------QAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387
Score = 56.2 bits (134), Expect = 4e-07
Identities = 51/204 (25%), Positives = 91/204 (44%), Gaps = 23/204 (11%)
Query: 472 RGRSWVMIEPSGAVQRDQTVLEGG-PCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDS 530
RG+ V P + + T L+ G P + C P+ W L +G L P S
Sbjct: 381 RGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRW-LKNGVPLS-----PQS 434
Query: 531 KFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVY-----RVLVQSPSTQPAE-KDT 584
+ +++ G L I ++ SD+G+YQC+A+ + +Y ++L +P+ + K T
Sbjct: 435 RVEMVN-GVLMIHNVNQSDAGMYQCLAENKYGA---IYASAELKILASAPTFALNQLKKT 490
Query: 585 VTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVS 644
+ + K+ + V + C P+ +SW +R + + +LP+G+L I S
Sbjct: 491 IIVTKD--QEVVIECKPQGSPKPTISWKKGDRAV----RENKRIAILPDGSLRILNASKS 544
Query: 645 DSGYYRCVAVNQQGADHFTVGITV 668
D G Y C N G+ ++V
Sbjct: 545 DEGKYVCRGENVFGSAEIIASLSV 568
Score = 46.2 bits (108), Expect = 5e-04
Identities = 61/293 (20%), Positives = 110/293 (37%), Gaps = 59/293 (20%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
T +G ++ C + P+I W+ +G I P S L I +++ D
Sbjct: 311 TAAKGTTVKMECFALGNPVPTITWMKVNGYI-------PSKARLRKSQAVLEIPNVQLDD 363
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHL 609
+G+Y+C A+ + + +R +Q + + + G + C A P
Sbjct: 364 AGIYECRAE--NSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTY 421
Query: 610 SWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVT 669
W+ L+ S V M+ NG L I V SD+G Y+C+A N+ GA + + + +
Sbjct: 422 RWLKNGV----PLSPQSRVEMV-NGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKIL 476
Query: 670 KKGSGLPSKRGRRPGAKALSRVREDIVEDEGGSGMGDEENTSRRLLHPKDQEVFLKTKDD 729
AL+++++ I+ KDQEV ++ K
Sbjct: 477 ASAPTF-----------ALNQLKKTIIV-------------------TKDQEVVIECKPQ 506
Query: 730 AI--------NGDKKAKKGRR-------KLKLWKHSEKEPETNVAEGRRVFES 767
GD+ ++ +R L++ S+ + V G VF S
Sbjct: 507 GSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGS 559
Score = 45.8 bits (107), Expect = 6e-04
Identities = 52/200 (26%), Positives = 76/200 (38%), Gaps = 36/200 (18%)
Query: 482 SGAVQRDQTVLEGGPCQLSCNVKASESPSIF--WVLPDGSILKAPMDDPDSKFSILSSGW 539
SG + +V EG L C+ SP I WV + A + +F +G
Sbjct: 198 SGRTRSAVSVREGQGVVLMCS-PPPHSPEIIYSWVFNEFPSFVA---EDSRRFISQETGN 253
Query: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKD---------------- 583
L I ++ SD G Y C+ + V V SP T ++
Sbjct: 254 LYISKVQTSDVGSYICLVK------NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFP 307
Query: 584 -TVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQ 642
TVT K G +V + C AL P ++W+ +N + L IP VQ
Sbjct: 308 FTVTAAK--GTTVKMECFALGNPVPTITWMK-----VNGYIPSKARLRKSQAVLEIPNVQ 360
Query: 643 VSDSGYYRCVAVNQQGADHF 662
+ D+G Y C A N +G + F
Sbjct: 361 LDDAGIYECRAENSRGKNSF 380
Score = 44.7 bits (104), Expect = 0.001
Identities = 44/165 (26%), Positives = 71/165 (43%), Gaps = 20/165 (12%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ 558
L+C V+ + PS W L +G+ + + D ++S++ ++ E DSG YQC+A
Sbjct: 121 LNCEVRGNPVPSYRW-LRNGTEIDL---ESDYRYSLIDGTFIISNPSEAKDSGHYQCLA- 175
Query: 559 VRDEMDRMVYRVLVQSPSTQPA------EKDTVTIGKNPGESVTLPCNALA-IPEAHLSW 611
V +L + + Q A + + G+ V L C+ PE SW
Sbjct: 176 -----TNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSW 230
Query: 612 ILPNRRIINDLANTSHVYM-LPNGTLSIPKVQVSDSGYYRCVAVN 655
+ + +A S ++ G L I KVQ SD G Y C+ N
Sbjct: 231 VF--NEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273
Score = 35.0 bits (79), Expect = 1.1
Identities = 41/159 (25%), Positives = 58/159 (36%), Gaps = 16/159 (10%)
Query: 503 VKASESPSIFWVLPDGSILKAPMDDPD-SKFSILSSGWLRIKSMEPSDSGLYQCIAQVRD 561
+K S S S+F GS + P S S WL S LY +
Sbjct: 37 IKKSSSSSLF-----GSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQ 91
Query: 562 EMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIIND 621
+ V VQ P D + + + V L C P W+ I D
Sbjct: 92 DESVDYGPVFVQEPD------DIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEI--D 143
Query: 622 LANTSHVYMLPNGTLSIPKV-QVSDSGYYRCVAVNQQGA 659
L + + Y L +GT I + DSG+Y+C+A N G+
Sbjct: 144 L-ESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGS 181
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 150 bits (380), Expect = 1e-35
Identities = 155/576 (26%), Positives = 232/576 (40%), Gaps = 56/576 (9%)
Query: 2065 IHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAP-KDSGRYECV 2123
+ ++C + P+PS RW L +GT+I +L +GT I N + KDSG Y+C+
Sbjct: 45 VALNCEVRGNPVPSYRW-LRNGTEIDLESDYRYSLI---DGTFIISNPSEAKDSGHYQCL 100
Query: 2124 AANLVGSA---RRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILW 2180
A N VGS T+Q A +G + VR G + L CS P I++
Sbjct: 101 ATNTVGSILSREATLQF-----AYLGNFSGRTRSAVSVREGQGVVLMCSPPPHS-PEIIY 154
Query: 2181 RLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVV------- 2233
+ R G L + V D G Y+C+ +N V + V+
Sbjct: 155 SWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLT 214
Query: 2234 LKVDVVMKP--AKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQS 2291
L+ D VM KIE G +K++C A G P P I+W +G +
Sbjct: 215 LRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYI------- 267
Query: 2292 DDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNK 2351
S R ++ + L V + + G Y C AEN GK+ R +++V T P +
Sbjct: 268 -PSKARLRK----SQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKL 322
Query: 2352 TYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRS 2411
Q+ G + C+A G+P P WL +P S + +G L+I +S
Sbjct: 323 N--DTQLDSGSPLRWECKATGKPRPTYRWLK---NGVPLSPQSRVEMVNGVLMIHNVNQS 377
Query: 2412 DSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGI 2471
D+G Y CL N G + + + P N T I +I+CK +G
Sbjct: 378 DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTI---IVTKDQEVVIECKPQGS 434
Query: 2472 PTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLIL 2531
P P + W + V RI + +GSL I + KSD + VC N G A +I
Sbjct: 435 PKPTISWKKGDRAVRE----NKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIA 490
Query: 2532 QLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAA--GTPTPSLVWVL---PNGTDLQS 2586
L+V EP I P ++T G +I LNC A + + W L P + +
Sbjct: 491 SLSVKEPTR--IELTPKRTELT--VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEG 546
Query: 2587 GQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAA 2622
G + L I + + AG Y C + A
Sbjct: 547 GHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTA 582
Score = 140 bits (354), Expect = 1e-32
Identities = 127/468 (27%), Positives = 199/468 (42%), Gaps = 40/468 (8%)
Query: 2364 VTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQK-AQRSDSGNYTCLVRN 2422
V + CE +G P+P WL ++ S +Y + DGT +I ++ DSG+Y CL N
Sbjct: 45 VALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI-DGTFIISNPSEAKDSGHYQCLATN 103
Query: 2423 SAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVL--WAF 2480
+ G +G +VRE G ++ C +P ++ W F
Sbjct: 104 TVGSILSREATLQFAYLGNFSGRTRSAVSVRE----GQGVVLMCSPPP-HSPEIIYSWVF 158
Query: 2481 PEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVL---- 2536
E A R G+L I ++ SD +C+ +N AR++ T L
Sbjct: 159 NEFPSFVAE-DSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRN 217
Query: 2537 -----EPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQ 2591
E K H P + +TA G T+ + C A G P P++ W+ NG + S +L+
Sbjct: 218 DGVMGEYEPKIEVHFPFT--VTAAKGTTVKMECFALGNPVPTITWMKVNGY-IPSKARLR 274
Query: 2592 RFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIIN 2651
K+ +L I + DAG Y C A N+ G L+V P ++ N + +
Sbjct: 275 ----KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKL-NDTQLDS 329
Query: 2652 GETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVC 2711
G L+ C G + + W L NG+ L PQ+ RV ++ NG L + + D G Y C
Sbjct: 330 GSPLRWECKATGKPRPTYRW-LKNGVPL-SPQS--RVEMV-NGVLMIHNVNQSDAGMYQC 384
Query: 2712 RMETEYGPSVTSIPVIVIAYPPRIT-SEPTPVIYTRPGNTVKLNCMAMGIPKADITWELP 2770
E +YG S + ++A P ++ I V + C G PK I+W+
Sbjct: 385 LAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKG 444
Query: 2771 DKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
D++ R + P GSL I +A++ D G Y C +N+ GS
Sbjct: 445 DRA-------VRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGS 485
Score = 129 bits (324), Expect = 4e-29
Identities = 124/552 (22%), Positives = 223/552 (40%), Gaps = 57/552 (10%)
Query: 1858 KSPQTVSVTAETDTVFPCEATG-KPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIR 1916
++ VSV V C P+ +W + + ++R RF + G L I
Sbjct: 126 RTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSR--RFISQETGNLYIS 183
Query: 1917 KVQVQDRGQYMCTASNLHGLDRMVVLLS-VTVQQPQILASHYQDVTVYL--------GDT 1967
KVQ D G Y+C N R++ + +T++ ++ + + V+ G T
Sbjct: 184 KVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTT 243
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVA 2027
+ MEC A G P P I+W+ + + P + R+ L I D G+Y+C A
Sbjct: 244 VKMECFALGNPVPTITWMKVNGYI-----PSKARLR-KSQAVLEIPNVQLDDAGIYECRA 297
Query: 2028 SNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGT 2087
N+ G +S +L V P + EKL + L G + C A P P+ RW L +G
Sbjct: 298 ENSRGKNSFRGQLQVYTYPHWV--EKLNDTQLDSGSPLRWECKATGKPRPTYRW-LKNGV 354
Query: 2088 QIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANAR 2147
+ P + NG L I N+ D+G Y+C+A N G+ + +L + +A
Sbjct: 355 PLSPQSRVE-----MVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFA 409
Query: 2148 ITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLV 2207
+ + V + ++C G P P I W+ + + + + RI + +G+L
Sbjct: 410 LNQLK-KTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRE-----NKRIAILPDGSLR 463
Query: 2208 VKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVA 2267
+ + + D G Y+C N G ++ + V +P +IE + ++ G + ++C A
Sbjct: 464 ILNASKSDEGKYVCRGENVFGSAEIIASLS-VKEPTRIELTPKRT-ELTVGESIVLNCKA 521
Query: 2268 TGLPNPEIS--WSLPDGSLVNSFMQSDDSGGRTKRY-VVFNNGTLYFNEVGMREEGDYTC 2324
+ +++ W+L + ++ GG + ++ L + + G Y C
Sbjct: 522 IHDASLDVTFYWTLKGQPI-----DFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGC 576
Query: 2325 FAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPT 2384
+V T ++ ++ L V+ P G V E E ++W
Sbjct: 577 ---------------RVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAA 621
Query: 2385 NKVIPTSSEKYQ 2396
+ P SS Q
Sbjct: 622 DNHSPISSYNLQ 633
Score = 126 bits (317), Expect = 3e-28
Identities = 126/512 (24%), Positives = 204/512 (39%), Gaps = 46/512 (8%)
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVA 2027
+A+ C +G P P W+ R + + R +L + + + D G Y+C+A
Sbjct: 45 VALNCEVRGNPVPSYRWL---RNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLA 101
Query: 2028 SNAAGAD-SLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKA-APLPSVRWVLGD 2085
+N G+ S L A L + + +S+ G + + C+ +P WV +
Sbjct: 102 TNTVGSILSREATLQFAYLGNFSGRTR-SAVSVREGQGVVLMCSPPPHSPEIIYSWVFNE 160
Query: 2086 GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAAN 2145
G LYI + D G Y C+ N V +A R + N
Sbjct: 161 FPSFVAED--SRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNA-RVLSPPTPLTLRN 217
Query: 2146 ARITGTSPRRTDVRY--------GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSR 2197
+ G + +V + G T+K++C A G+P P I W ++ +R
Sbjct: 218 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITW-----MKVNGYIPSKAR 272
Query: 2198 IKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFY 2257
++ + L + +V DAG Y C A N G + ++ V P +E + ND ++
Sbjct: 273 LRK-SQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVE--KLNDTQLDS 329
Query: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
G L+ +C ATG P P W L N S S V NG L + V
Sbjct: 330 GSPLRWECKATGKPRPTYRW------LKNGVPLSPQS------RVEMVNGVLMIHNVNQS 377
Query: 2318 EEGDYTCFAENQVGKDEMRVRVKVV-TAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMP 2376
+ G Y C AEN+ G +K++ +AP N+ + V V + C+ +G P P
Sbjct: 378 DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP 437
Query: 2377 KVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVN 2436
++W V +++ I DG+L I A +SD G Y C N G + V
Sbjct: 438 TISWKKGDRAV--RENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVK 495
Query: 2437 VQPPKINGNPNPITTVREIAAGGSRKLIDCKA 2468
+P +I +T R G +++CKA
Sbjct: 496 -EPTRIE-----LTPKRTELTVGESIVLNCKA 521
Score = 126 bits (317), Expect = 3e-28
Identities = 149/594 (25%), Positives = 240/594 (40%), Gaps = 69/594 (11%)
Query: 2166 LDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTD-KDAGDYLCVAR 2224
L+C G+P P W L + ID D R + +GT ++ + ++ KD+G Y C+A
Sbjct: 47 LNCEVRGNPVPSYRW-LRNGTEID--LESDYRYSLI-DGTFIISNPSEAKDSGHYQCLAT 102
Query: 2225 NKVGDDYVVLKVDVVMKPAKIEH---KEENDHKVFYGGDLKVDCVATGLPNPEISWSLPD 2281
N VG +L + ++ A + + + + V G + + C + +PEI +S
Sbjct: 103 NTVGS---ILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMC-SPPPHSPEIIYSWVF 158
Query: 2282 GSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKV 2341
SF+ D ++R++ G LY ++V + G Y C +N V RV
Sbjct: 159 NEFP-SFVAED-----SRRFISQETGNLYISKVQTSDVGSYICLVKNTV----TNARVLS 208
Query: 2342 VTAPATIRN-------KTYLAVQVPY------GDVVTVACEAKGEPMPKVTWLSPTNKVI 2388
P T+RN + + V P+ G V + C A G P+P +TW+ N I
Sbjct: 209 PPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMK-VNGYI 267
Query: 2389 PTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQP---PKINGN 2445
P+ + + L I Q D+G Y C NS G++ + V P K+N
Sbjct: 268 PSKARLRK--SQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDT 325
Query: 2446 PNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDI 2505
GS +CKA G P P W GV L + NG L I
Sbjct: 326 Q---------LDSGSPLRWECKATGKPRPTYRW-LKNGVPLSPQSRVEMV----NGVLMI 371
Query: 2506 RSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH-DPISEKITAMAGHTISLNC 2564
++ +SD+ C+A N+ G +L +L P F + + + I + + C
Sbjct: 372 HNVNQSDAGMYQCLAENKYGAIYASAELKILA--SAPTFALNQLKKTIIVTKDQEVVIEC 429
Query: 2565 SAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGH 2624
G+P P++ W + ++ ++ +R DG L I S D G Y C N G
Sbjct: 430 KPQGSPKPTISWKKGD----RAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGS 485
Query: 2625 TERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTP--PGAGQGRFSWTL---PNGMHL 2679
E + SL V +P + + GE++ L C + F WTL P
Sbjct: 486 AEIIASLSV-KEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEE 544
Query: 2680 EGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPP 2733
EG + + L +R + G Y CR++T SV+ +++ PP
Sbjct: 545 EGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTT-ADSVSDEAELLVRGPP 597
Score = 116 bits (291), Expect = 3e-25
Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 25/327 (7%)
Query: 1849 LGE-KPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEV 1907
+GE +P+I P TV+ T C A G P P +TW KV+ + R+++ +
Sbjct: 221 MGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVN--GYIPSKARLRKSQA 278
Query: 1908 LKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDT 1967
+ L I VQ+ D G Y C A N G + L V + D + G
Sbjct: 279 V----LEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV--EKLNDTQLDSGSP 332
Query: 1968 IAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVA 2027
+ EC A G P P W+ + +SP + R+ + N L I + SD G+Y+C+A
Sbjct: 333 LRWECKATGKPRPTYRWL----KNGVPLSP-QSRVEM-VNGVLMIHNVNQSDAGMYQCLA 386
Query: 2028 SNAAGADSLAIRLHVAALPPVIHQEKL-ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDG 2086
N GA + L + A P +L + I + + I C + +P P++ W GD
Sbjct: 387 ENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGD- 445
Query: 2087 TQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANA 2146
+R ++ + + P+G+L I N + D G+Y C N+ GSA L+V+
Sbjct: 446 RAVRENK----RIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEP---T 498
Query: 2147 RITGTSPRRTDVRYGGTLKLDCSASGD 2173
RI T P+RT++ G ++ L+C A D
Sbjct: 499 RIELT-PKRTELTVGESIVLNCKAIHD 524
Score = 110 bits (276), Expect = 2e-23
Identities = 141/604 (23%), Positives = 232/604 (38%), Gaps = 81/604 (13%)
Query: 1855 ILTKSPQTVSVTAETD---TVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNG 1911
+ + P + ++D CE G P P W + T + + R L +G
Sbjct: 26 VFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYS----LIDG 81
Query: 1912 TLVIRKV-QVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQI---LASHYQDVTVYLGDT 1967
T +I + +D G Y C A+N G ++ T+Q + V+V G
Sbjct: 82 TFIISNPSEAKDSGHYQCLATNTVG---SILSREATLQFAYLGNFSGRTRSAVSVREGQG 138
Query: 1968 IAMECLAKGTPAPQI--SWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKC 2025
+ + C + +P+I SW+F + + V+ R E L I + SD G Y C
Sbjct: 139 VVLMC-SPPPHSPEIIYSWVFNEFPSF--VAEDSRRFISQETGNLYISKVQTSDVGSYIC 195
Query: 2026 VASNA-------AGADSLAIRLH--VAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPL 2076
+ N + L +R + P I ++ G ++ + C A P+
Sbjct: 196 LVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPV 255
Query: 2077 PSVRWVLGDG-----TQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSA 2131
P++ W+ +G ++R SQ L I N+ D+G YEC A N G
Sbjct: 256 PTITWMKVNGYIPSKARLRKSQ-----------AVLEIPNVQLDDAGIYECRAENSRGKN 304
Query: 2132 RRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDAL 2191
QL V T + G L+ +C A+G P P W +
Sbjct: 305 SFRGQLQVYTYPHWVE----KLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPL---- 356
Query: 2192 FSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMK-PAKIEHKEE 2250
S SR+++ NG L++ +V DAG Y C+A NK G Y ++ ++ P ++ +
Sbjct: 357 -SPQSRVEM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLK 414
Query: 2251 NDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLY 2310
V ++ ++C G P P ISW + D + KR + +G+L
Sbjct: 415 KTIIVTKDQEVVIECKPQGSPKPTISWK-----------KGDRAVRENKRIAILPDGSLR 463
Query: 2311 FNEVGMREEGDYTCFAENQVGKDEM--RVRVKVVTAPATIRNKTYLAVQVPYGDVVTVAC 2368
+EG Y C EN G E+ + VK T +T L V G+ + + C
Sbjct: 464 ILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTV----GESIVLNC 519
Query: 2369 EAKGEPMPKVTWLSPTNKVIPTSSEKYQIY--------QDGTLLIQKAQRSDSGNYTCLV 2420
+A + VT+ T K P E+ + L+I+ +G Y C V
Sbjct: 520 KAIHDASLDVTFYW-TLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRV 578
Query: 2421 RNSA 2424
+ +A
Sbjct: 579 QTTA 582
Score = 88.6 bits (218), Expect = 8e-17
Identities = 77/286 (26%), Positives = 121/286 (42%), Gaps = 34/286 (11%)
Query: 2560 ISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSV-DAGAYRCVA 2618
++LNC G P PS W L NGT++ + Y DG IS S D+G Y+C+A
Sbjct: 45 VALNCEVRGNPVPSYRW-LRNGTEIDLESDYR--YSLIDGTFIISNPSEAKDSGHYQCLA 101
Query: 2619 RNAAGHT-ERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPG-AGQGRFSWTLPNG 2676
N G R +L+ + + + VS+ G+ + L C+PP + + +SW
Sbjct: 102 TNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEF 161
Query: 2677 MHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRME-TEYGPSVTSIPV--------I 2727
+ +S + G L + + D G+Y+C ++ T V S P +
Sbjct: 162 PSFVAEDSRRFISQ-ETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGV 220
Query: 2728 VIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWE-----LPDKSHLKAGVQAR 2782
+ Y P+I + G TVK+ C A+G P ITW +P K+ L+
Sbjct: 221 MGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKS---- 276
Query: 2783 LYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHVF 2828
Q L I + DAG Y+C A+N G +S + V+
Sbjct: 277 ---------QAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 313
Score = 56.2 bits (134), Expect = 4e-07
Identities = 51/204 (25%), Positives = 91/204 (44%), Gaps = 23/204 (11%)
Query: 472 RGRSWVMIEPSGAVQRDQTVLEGG-PCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDS 530
RG+ V P + + T L+ G P + C P+ W L +G L P S
Sbjct: 307 RGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRW-LKNGVPLS-----PQS 360
Query: 531 KFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVY-----RVLVQSPSTQPAE-KDT 584
+ +++ G L I ++ SD+G+YQC+A+ + +Y ++L +P+ + K T
Sbjct: 361 RVEMVN-GVLMIHNVNQSDAGMYQCLAENKYGA---IYASAELKILASAPTFALNQLKKT 416
Query: 585 VTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVS 644
+ + K+ + V + C P+ +SW +R + + +LP+G+L I S
Sbjct: 417 IIVTKD--QEVVIECKPQGSPKPTISWKKGDRAV----RENKRIAILPDGSLRILNASKS 470
Query: 645 DSGYYRCVAVNQQGADHFTVGITV 668
D G Y C N G+ ++V
Sbjct: 471 DEGKYVCRGENVFGSAEIIASLSV 494
Score = 46.2 bits (108), Expect = 5e-04
Identities = 61/293 (20%), Positives = 110/293 (37%), Gaps = 59/293 (20%)
Query: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
T +G ++ C + P+I W+ +G I P S L I +++ D
Sbjct: 237 TAAKGTTVKMECFALGNPVPTITWMKVNGYI-------PSKARLRKSQAVLEIPNVQLDD 289
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHL 609
+G+Y+C A+ + + +R +Q + + + G + C A P
Sbjct: 290 AGIYECRAE--NSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTY 347
Query: 610 SWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVT 669
W+ L+ S V M+ NG L I V SD+G Y+C+A N+ GA + + + +
Sbjct: 348 RWLKNGV----PLSPQSRVEMV-NGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKIL 402
Query: 670 KKGSGLPSKRGRRPGAKALSRVREDIVEDEGGSGMGDEENTSRRLLHPKDQEVFLKTKDD 729
AL+++++ I+ KDQEV ++ K
Sbjct: 403 ASAPTF-----------ALNQLKKTIIV-------------------TKDQEVVIECKPQ 432
Query: 730 AI--------NGDKKAKKGRR-------KLKLWKHSEKEPETNVAEGRRVFES 767
GD+ ++ +R L++ S+ + V G VF S
Sbjct: 433 GSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGS 485
Score = 45.8 bits (107), Expect = 6e-04
Identities = 52/200 (26%), Positives = 76/200 (38%), Gaps = 36/200 (18%)
Query: 482 SGAVQRDQTVLEGGPCQLSCNVKASESPSIF--WVLPDGSILKAPMDDPDSKFSILSSGW 539
SG + +V EG L C+ SP I WV + A + +F +G
Sbjct: 124 SGRTRSAVSVREGQGVVLMCS-PPPHSPEIIYSWVFNEFPSFVA---EDSRRFISQETGN 179
Query: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKD---------------- 583
L I ++ SD G Y C+ + V V SP T ++
Sbjct: 180 LYISKVQTSDVGSYICLVK------NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFP 233
Query: 584 -TVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQ 642
TVT K G +V + C AL P ++W+ +N + L IP VQ
Sbjct: 234 FTVTAAK--GTTVKMECFALGNPVPTITWMK-----VNGYIPSKARLRKSQAVLEIPNVQ 286
Query: 643 VSDSGYYRCVAVNQQGADHF 662
+ D+G Y C A N +G + F
Sbjct: 287 LDDAGIYECRAENSRGKNSF 306
Score = 44.7 bits (104), Expect = 0.001
Identities = 44/165 (26%), Positives = 71/165 (43%), Gaps = 20/165 (12%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQ 558
L+C V+ + PS W L +G+ + + D ++S++ ++ E DSG YQC+A
Sbjct: 47 LNCEVRGNPVPSYRW-LRNGTEIDL---ESDYRYSLIDGTFIISNPSEAKDSGHYQCLA- 101
Query: 559 VRDEMDRMVYRVLVQSPSTQPA------EKDTVTIGKNPGESVTLPCNALA-IPEAHLSW 611
V +L + + Q A + + G+ V L C+ PE SW
Sbjct: 102 -----TNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSW 156
Query: 612 ILPNRRIINDLANTSHVYM-LPNGTLSIPKVQVSDSGYYRCVAVN 655
+ + +A S ++ G L I KVQ SD G Y C+ N
Sbjct: 157 VF--NEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 199
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 147 bits (372), Expect = 1e-34
Identities = 149/608 (24%), Positives = 232/608 (38%), Gaps = 83/608 (13%)
Query: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWT--------KVSTGALMTPNT 1900
L E P I +SP+ + V D CEA+GKP+ WT K G + +
Sbjct: 26 LMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSP 85
Query: 1901 RIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDV 1960
F + N + ++ Q G Y C ASN G + + P+ + V
Sbjct: 86 HSGSFTITGNNSNFAQRFQ----GIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPV 141
Query: 1961 TVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPV----EGRITLHENRTLSIKEAS 2016
V G+++ + C P P P R W + + R+T+ +N L
Sbjct: 142 EVEEGESVVLPC----NPPPSAE---PLRIYWMNSKILHIKQDERVTMGQNGNLYFANVL 194
Query: 2017 FSDRGVYKCVASNAAGADSLA----IRLHVAALPPVIHQEKLENISLPPGLSIHI----- 2067
SD ++ G ++ I L V A +I ++ + P S H+
Sbjct: 195 TSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMI--DRKPRLLFPTNSSSHLVALQG 252
Query: 2068 -----HCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNG--TLYIRNLAPKDSGRY 2120
C A+ P P+++W +RPS + + + N TL + + +D G Y
Sbjct: 253 QPLVLECIAEGFPTPTIKW-------LRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEY 305
Query: 2121 ECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILW 2180
C+A N +GSAR + V+ A P+ G T +LDC G P P + W
Sbjct: 306 RCLAENSLGSARHAYYVTVEAAPYWLH----KPQSHLYGPGETARLDCQVQGRPQPEVTW 361
Query: 2181 RLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVM 2240
R+ + + RI+ G L++ +V D C ARN+ G + VV
Sbjct: 362 RINGIPVEELAKDQKYRIQ---RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQ 418
Query: 2241 KPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKR 2300
PAKI + + G + C A G P P + W DG+ V + +R
Sbjct: 419 LPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL----------QDER 468
Query: 2301 YVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAP-------ATIRNKTY 2353
+ + NGTL ++ + G Y C A N + +KV A +TI K
Sbjct: 469 FFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKK-- 526
Query: 2354 LAVQVPYGDVVTVACEAKGEP--MPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRS 2411
G VT C+A +P P +TW + +DG L+I S
Sbjct: 527 -------GSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYS 579
Query: 2412 DSGNYTCL 2419
D GNY+C+
Sbjct: 580 DQGNYSCV 587
Score = 123 bits (309), Expect = 2e-27
Identities = 148/614 (24%), Positives = 241/614 (39%), Gaps = 67/614 (10%)
Query: 2148 ITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRL------PSKRMIDALFSFDSRIKVF 2201
IT SPRR V + L C ASG P + W P + + ++
Sbjct: 32 ITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFT 91
Query: 2202 ANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEE-NDHKVFYGGD 2260
G + + G Y C A NK+G + ++ ++ + A KE +V G
Sbjct: 92 ITGNN--SNFAQRFQGIYRCFASNKLGTA-MSHEIRLMAEGAPKWPKETVKPVEVEEGES 148
Query: 2261 LKVDCVATGLPNP-EISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYF-NEVGMRE 2318
+ + C P I W S + Q + R + NG LYF N +
Sbjct: 149 VVLPCNPPPSAEPLRIYWM---NSKILHIKQDE-------RVTMGQNGNLYFANVLTSDN 198
Query: 2319 EGDYTCFAE-----NQVGKDEMRVRVKVVTAPA---------TIRNKTYLAVQVPYGDVV 2364
DY C A + K+ + +RVK + T + +A+Q G +
Sbjct: 199 HSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ---GQPL 255
Query: 2365 TVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSA 2424
+ C A+G P P + WL P+ + P YQ + TL + K D G Y CL NS
Sbjct: 256 VLECIAEGFPTPTIKWLRPSGPM-PADRVTYQNHNK-TLQLLKVGEEDDGEYRCLAENSL 313
Query: 2425 GEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGV 2484
G R ++ V P ++ + + G +DC+ +G P P V W G+
Sbjct: 314 GSARHAYYVTVEAAPYWLHKPQS------HLYGPGETARLDCQVQGRPQPEVTWRI-NGI 366
Query: 2485 VLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIF 2544
+ + + G+L + +++ SD++ C ARN G + V++ K +
Sbjct: 367 PVEELAKDQKYRIQ-RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 425
Query: 2545 HDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHIS 2604
D ++ A+ G T L C A G P PS+ W+ +GT + Q +RF+ A+G L I
Sbjct: 426 AD--NQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL---QDERFFPYANGTLGIR 480
Query: 2605 GLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGA 2664
L + D G Y C+A N + + +LKV + + + + G + C
Sbjct: 481 DLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIE-KKGSRVTFTC----- 534
Query: 2665 GQGRFSWTLPNGMHLEGP----QTLGRVS--LLDNGTLTVREASVFDRGTYVCRMETEYG 2718
Q F +L + G Q LG +++G L + D+G Y C TE
Sbjct: 535 -QASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELD 593
Query: 2719 PSVTSIPVIVIAYP 2732
+ ++V+ P
Sbjct: 594 VVESRAQLLVVGSP 607
Score = 118 bits (295), Expect = 9e-26
Identities = 146/648 (22%), Positives = 256/648 (39%), Gaps = 74/648 (11%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPF-VTWTKVSTGALMTPNTRIQRFEVLKNG 1911
P+ ++ + V V V PC +P + W + + + +R + +NG
Sbjct: 131 PKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMN----SKILHIKQDERVTMGQNG 186
Query: 1912 TLVIRKVQVQDR-GQYMC--------TASNLHGLD-RMVVLLSVTVQQPQIL--ASHYQD 1959
L V D Y+C T +D R+ S+ ++P++L +
Sbjct: 187 NLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSH 246
Query: 1960 VTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSD 2019
+ G + +EC+A+G P P I W+ P + P + + N+TL + + D
Sbjct: 247 LVALQGQPLVLECIAEGFPTPTIKWLRPSGPM-----PADRVTYQNHNKTLQLLKVGEED 301
Query: 2020 RGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSV 2079
G Y+C+A N+ G+ A + V A P +H K ++ PG + + C + P P V
Sbjct: 302 DGEYRCLAENSLGSARHAYYVTVEAAPYWLH--KPQSHLYGPGETARLDCQVQGRPQPEV 359
Query: 2080 RWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
W + I + + G L + N+ P D+ +C A N G + V
Sbjct: 360 TWRING---IPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYV 416
Query: 2140 QRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIK 2199
+ A +T + V+ G T L C A G P P + W + D R
Sbjct: 417 VQLPAKI-LTADNQTYMAVQ-GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ----DERFF 470
Query: 2200 VFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGG 2259
+ANGTL ++ + D G Y C+A N + V + ++ +K A + G
Sbjct: 471 PYANGTLGIRDLQANDTGRYFCLAANDQNN--VTIMANLKVKDATQITQGPRSTIEKKGS 528
Query: 2260 DLKVDCVATGLPN--PEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
+ C A+ P+ P I+W DG + SD +Y + +G L + +
Sbjct: 529 RVTFTCQASFDPSLQPSITWR-GDGRDLQELGDSD-------KYFI-EDGRLVIHSLDYS 579
Query: 2318 EEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPK 2377
++G+Y+C A ++ E R ++ VV +P P +V + +
Sbjct: 580 DQGNYSCVASTELDVVESRAQLLVVGSPG------------PVPRLVLSDLHLLTQSQVR 627
Query: 2378 VTWLSPTNKVIPTSSEKYQI-YQDGTLLIQK--AQRSDSGNYTCLVRNSAGEDRKTVWIH 2434
V+W + P EKY I ++D + +K + GN T + + ++H
Sbjct: 628 VSWSPAEDHNAPI--EKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL------KLSPYVH 679
Query: 2435 VNVQPPKIN----GNPNPIT-TVREIAAGGSRKLIDCKAEGIPTPRVL 2477
+ IN G P+P++ TV A + +D K EG T ++
Sbjct: 680 YTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMV 727
Score = 92.8 bits (229), Expect = 4e-18
Identities = 111/477 (23%), Positives = 185/477 (38%), Gaps = 50/477 (10%)
Query: 2362 DVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD---GTLLIQK-----AQRSDS 2413
D +++ CEA G+P + W P +YQ G+ I AQR
Sbjct: 46 DDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQ- 104
Query: 2414 GNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAG-GSRKLIDCKAEGIP 2472
G Y C N G T H ++ P TV+ + G ++ C
Sbjct: 105 GIYRCFASNKLG----TAMSH-EIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSA 159
Query: 2473 TP-RVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDS-VQLVCMARNEGGEARLI 2530
P R+ W + + + R+T+ NG+L ++ SD+ +C A G R I
Sbjct: 160 EPLRIYWMNSKILHIKQD---ERVTMGQNGNLYFANVLTSDNHSDYICHAHFPG--TRTI 214
Query: 2531 LQL-----------TVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLP 2579
+Q ++++ + +F S + A+ G + L C A G PTP++ W+ P
Sbjct: 215 IQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRP 274
Query: 2580 NGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPE- 2638
+G + + + + ++K L + + D G YRC+A N+ G + V P
Sbjct: 275 SG-PMPADRVTYQNHNKT---LQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYW 330
Query: 2639 ANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTV 2698
+K +L GET +L C G Q +W + NG+ +E + + G L +
Sbjct: 331 LHKPQSHLYG--PGETARLDCQVQGRPQPEVTWRI-NGIPVE-ELAKDQKYRIQRGALIL 386
Query: 2699 REASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAM 2758
D C +G + + + V+ P +I + G+T L C A
Sbjct: 387 SNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAF 446
Query: 2759 GIPKADITWELPDKSHLKAGVQARLYGNRFL-HPQGSLTIQHATQRDAGFYKCMAKN 2814
G P + W D + + L RF + G+L I+ D G Y C+A N
Sbjct: 447 GAPVPSVQWLDEDGTTV-------LQDERFFPYANGTLGIRDLQANDTGRYFCLAAN 496
Score = 85.9 bits (211), Expect = 5e-16
Identities = 79/299 (26%), Positives = 121/299 (40%), Gaps = 23/299 (7%)
Query: 1843 ASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRI 1902
A+ +W KPQ P TA D C+ G+P+P VTW G + +
Sbjct: 326 AAPYWL--HKPQSHLYGP---GETARLD----CQVQGRPQPEVTWR--INGIPVEELAKD 374
Query: 1903 QRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTV 1962
Q++ + + G L++ VQ D C A N HGL + V +IL + Q
Sbjct: 375 QKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMA 433
Query: 1963 YLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGV 2022
G T + C A G P P + W+ D T + R + N TL I++ +D G
Sbjct: 434 VQGSTAYLLCKAFGAPVPSVQWLDED----GTTVLQDERFFPYANGTLGIRDLQANDTGR 489
Query: 2023 YKCVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAP--LPSVR 2080
Y C+A+N ++ L V + + + G + C A P PS+
Sbjct: 490 YFCLAANDQNNVTIMANLKVKDATQITQGPR--STIEKKGSRVTFTCQASFDPSLQPSIT 547
Query: 2081 WVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
W GDG ++ + + + +G L I +L D G Y CVA+ + QL V
Sbjct: 548 W-RGDGRDLQ--ELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV 603
Score = 71.2 bits (173), Expect = 1e-11
Identities = 77/313 (24%), Positives = 123/313 (39%), Gaps = 35/313 (11%)
Query: 2537 EPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHK 2596
E ME P+ + ++ ISL C A+G P W +G + ++L ++
Sbjct: 25 ELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWT-RDGVHFKPKEELGVTVYQ 83
Query: 2597 A--DGMLHISGLSSVDA----GAYRCVARNAAGHT-ERLVSLKVGLKPEANKQYHNLVSI 2649
+ G I+G +S A G YRC A N G + L P+ K+ V +
Sbjct: 84 SPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEV 143
Query: 2650 INGETLKLPCTPPGAGQG-RFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFD-RG 2707
GE++ LPC PP + + R W +H++ + RV++ NG L D
Sbjct: 144 EEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDE---RVTMGQNGNLYFANVLTSDNHS 200
Query: 2708 TYVCRMETEYGPSVTS---IPVIVIAYPPRITSEPTPVIYTR--------PGNTVKLNCM 2756
Y+C ++ I + V A I +P + T G + L C+
Sbjct: 201 DYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECI 260
Query: 2757 AMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQ--HATQRDAGFYKCMAKN 2814
A G P I W P + +R + + T+Q + D G Y+C+A+N
Sbjct: 261 AEGFPTPTIKWLRP---------SGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAEN 311
Query: 2815 ILGSDSKTTYIHV 2827
LGS Y+ V
Sbjct: 312 SLGSARHAYYVTV 324
Score = 57.8 bits (138), Expect = 2e-07
Identities = 46/164 (28%), Positives = 77/164 (46%), Gaps = 11/164 (6%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSG 551
++G L C + PS+ W+ DG+ + D +F ++G L I+ ++ +D+G
Sbjct: 434 VQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ-----DERFFPYANGTLGIRDLQANDTG 488
Query: 552 LYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIP--EAHL 609
Y C+A D+ + + L +TQ + TI K G VT C A P + +
Sbjct: 489 RYFCLA-ANDQNNVTIMANLKVKDATQITQGPRSTIEKK-GSRVTFTCQASFDPSLQPSI 546
Query: 610 SWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
+W + R + +L + S Y + +G L I + SD G Y CVA
Sbjct: 547 TW-RGDGRDLQELGD-SDKYFIEDGRLVIHSLDYSDQGNYSCVA 588
Score = 53.9 bits (128), Expect = 2e-06
Identities = 45/168 (26%), Positives = 75/168 (44%), Gaps = 12/168 (7%)
Query: 492 LEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSG-WLRIKSMEPSDS 550
L+G P L C + +P+I W+ P G PM P + + + L++ + D
Sbjct: 250 LQGQPLVLECIAEGFPTPTIKWLRPSG-----PM--PADRVTYQNHNKTLQLLKVGEEDD 302
Query: 551 GLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLS 610
G Y+C+A+ R Y V V++ + + G PGE+ L C P+ ++
Sbjct: 303 GEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYG--PGETARLDCQVQGRPQPEVT 360
Query: 611 WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
W + N + +LA Y + G L + VQ SD+ +C A N+ G
Sbjct: 361 WRI-NGIPVEELAK-DQKYRIQRGALILSNVQPSDTMVTQCEARNRHG 406
Score = 53.9 bits (128), Expect = 2e-06
Identities = 53/197 (26%), Positives = 82/197 (41%), Gaps = 27/197 (13%)
Query: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDD--PDSKFSILSSGWLRIKSMEPSDSG 551
G +L C V+ P + W I P+++ D K+ I G L + +++PSD+
Sbjct: 342 GETARLDCQVQGRPQPEVTW-----RINGIPVEELAKDQKYRI-QRGALILSNVQPSDTM 395
Query: 552 LYQCIAQVRDEMDRM-VYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLS 610
+ QC A+ R + Y +VQ P+ + D T G + L C A P +
Sbjct: 396 VTQCEARNRHGLLLANAYIYVVQLPA-KILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQ 454
Query: 611 WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG------------ 658
W+ + + + NGTL I +Q +D+G Y C+A N Q
Sbjct: 455 WLDEDGTTV---LQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKD 511
Query: 659 ADHFTVG--ITVTKKGS 673
A T G T+ KKGS
Sbjct: 512 ATQITQGPRSTIEKKGS 528
Score = 41.2 bits (95), Expect = 0.015
Identities = 48/191 (25%), Positives = 77/191 (40%), Gaps = 22/191 (11%)
Query: 491 VLEGGPCQLSCNVKASESP-SIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
V EG L CN S P I+W+ + IL D+ + ++ +G L ++ SD
Sbjct: 143 VEEGESVVLPCNPPPSAEPLRIYWM--NSKILHIKQDE---RVTMGQNGNLYFANVLTSD 197
Query: 550 SGL-YQCIAQ---VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNP--------GESVTL 597
+ Y C A R + + + V++ ++ K + N G+ + L
Sbjct: 198 NHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVL 257
Query: 598 PCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQ 657
C A P + W+ P+ + D Y N TL + KV D G YRC+A N
Sbjct: 258 ECIAEGFPTPTIKWLRPSGPMPADRVT----YQNHNKTLQLLKVGEEDDGEYRCLAENSL 313
Query: 658 GADHFTVGITV 668
G+ +TV
Sbjct: 314 GSARHAYYVTV 324
>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
sapiens]
Length = 1304
Score = 147 bits (370), Expect = 2e-34
Identities = 195/806 (24%), Positives = 307/806 (38%), Gaps = 116/806 (14%)
Query: 1942 LLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFP------DRRVWQTV 1995
LL VQ P I +D + + I ++C AKG P P SW D+ T+
Sbjct: 38 LLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTM 97
Query: 1996 SPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP---PVIHQE 2052
P G + ++ + + + + GVY+C A N GA A+ ++ P P+ +E
Sbjct: 98 KPGTGTLIIN----IMSEGKAETYEGVYQCTARNERGA---AVSNNIVVRPSRSPLWTKE 150
Query: 2053 KLENISLPPGLSIHIHCTAKAA-PLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRN 2111
KLE I+L G S+ + C P P + W+ ++ S+ + L NG LY N
Sbjct: 151 KLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGL----NGDLYFSN 206
Query: 2112 LAPKDSGR-YEC-----------------------------VAANLVGSARRTVQLNVQR 2141
+ P+D+ Y C +AANL + + + +R
Sbjct: 207 VLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRER 266
Query: 2142 AAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR-----LPSKRMIDALFSFDS 2196
G + + ++R G L L+C A G P P I W LP R + F
Sbjct: 267 PPTFLTPEGNASNKEELR-GNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFE--- 322
Query: 2197 RIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVF 2256
TL + V++ D+G+Y C+A+N +G + + V V P I + + +
Sbjct: 323 -------KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQ--NLVLS 373
Query: 2257 YGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGM 2316
G D + C A G P P ISW L +G + + DD + + T+ F+ V
Sbjct: 374 PGEDGTLICRANGNPKPRISW-LTNGVPIE--IAPDDPSRK------IDGDTIIFSNVQE 424
Query: 2317 REEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMP 2376
R Y C A N+ G V V+ P I QV + C G P+P
Sbjct: 425 RSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLP 484
Query: 2377 KVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVN 2436
+ W K + Y ++++GTL I AQ+ +G YTC+ RN G + V + +
Sbjct: 485 TIEWFKGA-KGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK 543
Query: 2437 VQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPT--PRVLWAFPEGVVLPAPYYGNR 2494
P I P R GS +CK + T VLW + LP+ R
Sbjct: 544 -DPTWIVKQPEYAVVQR-----GSMVSFECKVKHDHTLSLTVLW-LKDNRELPS---DER 593
Query: 2495 ITVHGNGSLDIRSLRKSDSVQLVCMARN--EGGEARLILQLTVLEPMEKPIF---HDPIS 2549
TV L + + DS C+A + A +L + P P++ + P
Sbjct: 594 FTV-DKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFD 652
Query: 2550 EKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHIS--GLS 2607
++T ++ L+ + + + D L + G + LS
Sbjct: 653 LELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLS 712
Query: 2608 SVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQG 2667
++R +A N+ G + L EA++QY S E K P G G
Sbjct: 713 PYVNYSFRVMAVNSIGKS---------LPSEASEQYLTKAS----EPDKNPTAVEGLGSE 759
Query: 2668 R----FSWTLPNGMHLEGPQTLGRVS 2689
+W NG GP +VS
Sbjct: 760 PDNLVITWKPLNGFESNGPGLQYKVS 785
Score = 146 bits (368), Expect = 3e-34
Identities = 153/645 (23%), Positives = 253/645 (39%), Gaps = 82/645 (12%)
Query: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTG--------ALMTPNT 1900
L + P I +SP+ + + V CEA GKP P +WT+ T M P T
Sbjct: 42 LVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGT 101
Query: 1901 RIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDV 1960
++ G K + + G Y CTA N G ++ + P + +
Sbjct: 102 GTLIINIMSEG-----KAETYE-GVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPI 155
Query: 1961 TVYLGDTIAMECLAK-GTPAPQISWIF-------PDRRVWQ---------TVSPVEGRI- 2002
T+ G ++ + C G P P I W+ RV Q V P + R
Sbjct: 156 TLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTRED 215
Query: 2003 -----------TLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQ 2051
T+ + + +S+K S + + +A+N + + + P +
Sbjct: 216 YICYARFNHTQTIQQKQPISVKVISVDE--LNDTIAANLSDTEFYGAKSSRERPPTFLTP 273
Query: 2052 E-KLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPN--GTLY 2108
E N G + + C A+ P P + W DG L N V+ N TL
Sbjct: 274 EGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDG-------MLPKNRTVYKNFEKTLQ 326
Query: 2109 IRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDC 2168
I +++ DSG Y+C+A N +G+ T+ + V+ A T+P+ + G L C
Sbjct: 327 IIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAP----YWITAPQNLVLSPGEDGTLIC 382
Query: 2169 SASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG 2228
A+G+P PRI W + + D + T++ +V ++ + Y C A N+ G
Sbjct: 383 RANGNPKPRISWLTNG---VPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYG 439
Query: 2229 DDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSF 2288
V+V+ +P +I ++V +DC G P P I W F
Sbjct: 440 YLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW----------F 489
Query: 2289 MQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATI 2348
+ S YV+ NGTL G YTC A N++G + V +++ +
Sbjct: 490 KGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIV 549
Query: 2349 RNKTYLAVQVPYGDVVTVACEAKGEPMPKVT--WLSPTNKVIPTSSEKYQIYQDGTLLIQ 2406
+ Y VQ G +V+ C+ K + +T WL N+ +P S E++ + +D L++
Sbjct: 550 KQPEYAVVQ--RGSMVSFECKVKHDHTLSLTVLWLK-DNRELP-SDERFTVDKD-HLVVA 604
Query: 2407 KAQRSDSGNYTCLVRNSAGEDRKTVWIHV---NVQPPKINGNPNP 2448
DSG YTC+ + + + V P + PNP
Sbjct: 605 DVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNP 649
Score = 117 bits (294), Expect = 1e-25
Identities = 127/525 (24%), Positives = 210/525 (40%), Gaps = 69/525 (13%)
Query: 2345 PATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWL-SPTNKVIPTSSEKYQIYQDGTL 2403
P TI ++ + + + + CEAKG+P P +W + T+ I GTL
Sbjct: 45 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 104
Query: 2404 LIQ-----KAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAA- 2457
+I KA+ + G Y C RN G V ++ V+P + +P+ T ++
Sbjct: 105 IINIMSEGKAETYE-GVYQCTARNERGA---AVSNNIVVRPSR-----SPLWTKEKLEPI 155
Query: 2458 ---GGSRKLIDCKAE-GIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDS 2513
G ++ C+ G+P P + W LP R++ NG L ++ D+
Sbjct: 156 TLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQ---SERVSQGLNGDLYFSNVLPEDT 212
Query: 2514 VQ-LVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKIT------------------- 2553
+ +C AR + Q ++ + +D I+ ++
Sbjct: 213 REDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLT 272
Query: 2554 ---------AMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHIS 2604
+ G+ +SL C A G PTP + W +G L + + + + K ++H+S
Sbjct: 273 PEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGM-LPKNRTVYKNFEKTLQIIHVS 331
Query: 2605 GLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGA 2664
D+G Y+C+A+NA G +S++V P NLV + GE L C G
Sbjct: 332 ---EADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLV-LSPGEDGTLICRANGN 387
Query: 2665 GQGRFSWTLPNGMHLE-GPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTS 2723
+ R SW L NG+ +E P R +D T+ Y C EYG + +
Sbjct: 388 PKPRISW-LTNGVPIEIAPDDPSRK--IDGDTIIFSNVQERSSAVYQCNASNEYGYLLAN 444
Query: 2724 IPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARL 2783
V V+A PPRI + + L+C G P I W K + L
Sbjct: 445 AFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW-------FKGAKGSAL 497
Query: 2784 YGNRF-LHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ + + LH G+L I A + G Y C+A+N LG ++ +
Sbjct: 498 HEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEI 542
Score = 80.5 bits (197), Expect = 2e-14
Identities = 143/629 (22%), Positives = 234/629 (37%), Gaps = 77/629 (12%)
Query: 2239 VMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRT 2298
+++P I + D+ + ++ + C A G P P SW+ + D T
Sbjct: 42 LVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRN-----GTHFDIDKDPLVT 96
Query: 2299 KRYVVFNNGTLYFNEV--GMRE--EGDYTCFAENQVGKD-EMRVRVKVVTAPATIRNKTY 2353
+ GTL N + G E EG Y C A N+ G + V+ +P + K
Sbjct: 97 MKP---GTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLE 153
Query: 2354 LAVQVPYGDVVTVACEAK-GEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSD 2412
+ + G + + C G P P + W+ + + +P SE+ +G L D
Sbjct: 154 -PITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLP-QSERVSQGLNGDLYFSNVLPED 211
Query: 2413 SG-NYTCLVRNSAGE---------------DRKTVWIHVNVQPPKINGNPN-----PITT 2451
+ +Y C R + + D I N+ + G + P
Sbjct: 212 TREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFL 271
Query: 2452 VREIAAGGSRKL------IDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGN--GSL 2503
E A +L ++C AEG+PTP + WA +G+ LP NR TV+ N +L
Sbjct: 272 TPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGM-LPK----NR-TVYKNFEKTL 325
Query: 2504 DIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLN 2563
I + ++DS C+A+N G + T+ ++ + + + G +L
Sbjct: 326 QIIHVSEADSGNYQCIAKNALGA----IHHTISVRVKAAPYWITAPQNLVLSPGEDGTLI 381
Query: 2564 CSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADG-MLHISGLSSVDAGAYRCVARNAA 2622
C A G P P + W L NG ++ K DG + S + + Y+C A N
Sbjct: 382 CRANGNPKPRISW-LTNGVPIEIAPDDPS--RKIDGDTIIFSNVQERSSAVYQCNASNEY 438
Query: 2623 GHTERLVSLKVGLKPEANKQYHN-LVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEG 2681
G+ + V +P N L +I L C G+ W +G
Sbjct: 439 GYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWF----KGAKG 494
Query: 2682 PQTLGRVSLL-DNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPT 2740
+ +L +NGTL + A GTY C + G + + + I P I +P
Sbjct: 495 SALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVH-LEIKDPTWIVKQPE 553
Query: 2741 PVIYTRPGNTVKLNCMAMGIPKADIT--WELPDKSHLKAGVQARLYGNRFLHPQGSLTIQ 2798
+ R G+ V C +T W L D L + RF + L +
Sbjct: 554 YAVVQR-GSMVSFECKVKHDHTLSLTVLW-LKDNRELPSD-------ERFTVDKDHLVVA 604
Query: 2799 HATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ D+G Y C+A L S S + + V
Sbjct: 605 DVSDDDSGTYTCVANTTLDSVSASAVLSV 633
Score = 70.1 bits (170), Expect = 3e-11
Identities = 70/283 (24%), Positives = 120/283 (42%), Gaps = 21/283 (7%)
Query: 1817 SFITSSVQS-SGSFHQSSSKFFAGGPPASKFWS-LGEKPQILTKSPQTVSVTAETDTVFP 1874
+ I S+VQ S + +Q ++ G A+ F + L E P+ILT + V A +
Sbjct: 416 TIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLD 475
Query: 1875 CEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH 1934
C G P P + W K + G+ + + + + +NGTL I Q G Y C A N
Sbjct: 476 CAFFGSPLPTIEWFKGAKGSALHEDI----YVLHENGTLEIPVAQKDSTGTYTCVARNKL 531
Query: 1935 GLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAK--GTPAPQISWIFPDRRVW 1992
G+ + V L ++ P + + V G ++ EC K T + + W+ +R +
Sbjct: 532 GMAKNEVHLE--IKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL- 588
Query: 1993 QTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQE 2052
P + R T+ ++ L + + S D G Y CVA+ + S + L V A P
Sbjct: 589 ----PSDERFTVDKDH-LVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPT--PA 641
Query: 2053 KLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFL 2095
+ ++ PP + T + + W GD ++F+
Sbjct: 642 PVYDVPNPP---FDLELTDQLDKSVQLSWTPGDDNNSPITKFI 681
Score = 52.8 bits (125), Expect = 5e-06
Identities = 46/190 (24%), Positives = 79/190 (41%), Gaps = 11/190 (5%)
Query: 469 RQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDP 528
+ +R R + P G + L G L C + +P I+W DG + K
Sbjct: 261 KSSRERPPTFLTPEGNASNKEE-LRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYK 319
Query: 529 DSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIG 588
+ + + L+I + +DSG YQCIA ++ + + + + V+ + +
Sbjct: 320 NFEKT------LQIIHVSEADSGNYQCIA--KNALGAIHHTISVRVKAAPYWITAPQNLV 371
Query: 589 KNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGY 648
+PGE TL C A P+ +SW+ I ++A + T+ VQ S
Sbjct: 372 LSPGEDGTLICRANGNPKPRISWLTNGVPI--EIAPDDPSRKIDGDTIIFSNVQERSSAV 429
Query: 649 YRCVAVNQQG 658
Y+C A N+ G
Sbjct: 430 YQCNASNEYG 439
Score = 43.9 bits (102), Expect = 0.002
Identities = 44/164 (26%), Positives = 63/164 (38%), Gaps = 15/164 (9%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIA- 557
L C + P I W L +G ++ DDP K + + +++ S +YQC A
Sbjct: 380 LICRANGNPKPRISW-LTNGVPIEIAPDDPSRK---IDGDTIIFSNVQERSSAVYQCNAS 435
Query: 558 -QVRDEMDRMVYRVLVQSPST-QPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPN 615
+ + VL + P PA I P L C P + W
Sbjct: 436 NEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPA---LLDCAFFGSPLPTIEWF--- 489
Query: 616 RRIINDLANTSHVYML-PNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ A +Y+L NGTL IP Q +G Y CVA N+ G
Sbjct: 490 -KGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLG 532
Score = 39.7 bits (91), Expect = 0.043
Identities = 27/82 (32%), Positives = 37/82 (45%), Gaps = 14/82 (17%)
Query: 592 GESVTLPCNALAIPEAHLSW-----ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDS 646
G ++L C A +P + W +LP R VY TL I V +DS
Sbjct: 285 GNVLSLECIAEGLPTPIIYWAKEDGMLPKNRT---------VYKNFEKTLQIIHVSEADS 335
Query: 647 GYYRCVAVNQQGADHFTVGITV 668
G Y+C+A N GA H T+ + V
Sbjct: 336 GNYQCIAKNALGAIHHTISVRV 357
Score = 37.7 bits (86), Expect = 0.16
Identities = 34/114 (29%), Positives = 51/114 (44%), Gaps = 11/114 (9%)
Query: 552 LYQCIAQVRDEMDRMVYRVLVQSPS-TQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLS 610
L Q I+ + +D + LVQ P+ TQ + KD + +P E++ + C A P S
Sbjct: 23 LCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYII---DPRENIVIQCEAKGKPPPSFS 79
Query: 611 WILPNRRIINDLANTSHVYMLP-NGTLSIPKVQVSDS----GYYRCVAVNQQGA 659
W D+ V M P GTL I + + G Y+C A N++GA
Sbjct: 80 WTRNGTHF--DIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGA 131
Score = 37.0 bits (84), Expect = 0.28
Identities = 37/166 (22%), Positives = 65/166 (39%), Gaps = 16/166 (9%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVL-PDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
V+ P L C S P+I W GS L + + + +G L I +
Sbjct: 466 VIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDI------YVLHENGTLEIPVAQKDS 519
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHL 609
+G Y C+A+ + M + + ++ P+ + + + + G V+ C L
Sbjct: 520 TGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR--GSMVSFECKVKHDHTLSL 577
Query: 610 S--WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
+ W+ NR + +D + + L + V DSG Y CVA
Sbjct: 578 TVLWLKDNRELPSD-----ERFTVDKDHLVVADVSDDDSGTYTCVA 618
>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
sapiens]
Length = 1183
Score = 145 bits (367), Expect = 4e-34
Identities = 148/617 (23%), Positives = 245/617 (39%), Gaps = 79/617 (12%)
Query: 1849 LGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTG--------ALMTPNT 1900
L + P I +SP+ + + V CEA GKP P +WT+ T M P T
Sbjct: 36 LVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGT 95
Query: 1901 RIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDV 1960
++ G K + + G Y CTA N G ++ + P + +
Sbjct: 96 GTLIINIMSEG-----KAETYE-GVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPI 149
Query: 1961 TVYLGDTIAMECLAK-GTPAPQISWIF-------PDRRVWQ---------TVSPVEGRI- 2002
T+ G ++ + C G P P I W+ RV Q V P + R
Sbjct: 150 TLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTRED 209
Query: 2003 -----------TLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQ 2051
T+ + + +S+K S + + +A+N + + + P +
Sbjct: 210 YICYARFNHTQTIQQKQPISVKVISVDE--LNDTIAANLSDTEFYGAKSSRERPPTFLTP 267
Query: 2052 E-KLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPN--GTLY 2108
E N G + + C A+ P P + W DG L N V+ N TL
Sbjct: 268 EGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDG-------MLPKNRTVYKNFEKTLQ 320
Query: 2109 IRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDC 2168
I +++ DSG Y+C+A N +G+ T+ + V+ A T+P+ + G L C
Sbjct: 321 IIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAP----YWITAPQNLVLSPGEDGTLIC 376
Query: 2169 SASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVG 2228
A+G+P PRI W + + D + T++ +V ++ + Y C A N+ G
Sbjct: 377 RANGNPKPRISWLTNG---VPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYG 433
Query: 2229 DDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSF 2288
V+V+ +P +I ++V +DC G P P I W F
Sbjct: 434 YLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW----------F 483
Query: 2289 MQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATI 2348
+ S YV+ NGTL G YTC A N++G + V +++ +
Sbjct: 484 KGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIV 543
Query: 2349 RNKTYLAVQVPYGDVVTVACEAKGEPMPKVT--WLSPTNKVIPTSSEKYQIYQDGTLLIQ 2406
+ Y VQ G +V+ C+ K + +T WL N+ +P S E++ + +D L++
Sbjct: 544 KQPEYAVVQ--RGSMVSFECKVKHDHTLSLTVLWLK-DNRELP-SDERFTVDKD-HLVVA 598
Query: 2407 KAQRSDSGNYTCLVRNS 2423
DSG YTC+ +
Sbjct: 599 DVSDDDSGTYTCVANTT 615
Score = 140 bits (353), Expect = 2e-32
Identities = 191/796 (23%), Positives = 302/796 (37%), Gaps = 116/796 (14%)
Query: 1947 VQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFP------DRRVWQTVSPVEG 2000
VQ P I +D + + I ++C AKG P P SW D+ T+ P G
Sbjct: 37 VQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTG 96
Query: 2001 RITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP---PVIHQEKLENI 2057
+ ++ + + + + GVY+C A N GA A+ ++ P P+ +EKLE I
Sbjct: 97 TLIIN----IMSEGKAETYEGVYQCTARNERGA---AVSNNIVVRPSRSPLWTKEKLEPI 149
Query: 2058 SLPPGLSIHIHCTAKAA-PLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKD 2116
+L G S+ + C P P + W+ ++ S+ + L NG LY N+ P+D
Sbjct: 150 TLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGL----NGDLYFSNVLPED 205
Query: 2117 SGR-YEC-----------------------------VAANLVGSARRTVQLNVQRAAANA 2146
+ Y C +AANL + + + +R
Sbjct: 206 TREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFL 265
Query: 2147 RITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWR-----LPSKRMIDALFSFDSRIKVF 2201
G + + ++R G L L+C A G P P I W LP R + F
Sbjct: 266 TPEGNASNKEELR-GNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFE-------- 316
Query: 2202 ANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDL 2261
TL + V++ D+G+Y C+A+N +G + + V V P I + + + G D
Sbjct: 317 --KTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQ--NLVLSPGEDG 372
Query: 2262 KVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGD 2321
+ C A G P P ISW L +G + + DD + + T+ F+ V R
Sbjct: 373 TLICRANGNPKPRISW-LTNGVPIE--IAPDDPSRK------IDGDTIIFSNVQERSSAV 423
Query: 2322 YTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWL 2381
Y C A N+ G V V+ P I QV + C G P+P + W
Sbjct: 424 YQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWF 483
Query: 2382 SPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPK 2441
K + Y ++++GTL I AQ+ +G YTC+ RN G + V + + P
Sbjct: 484 KGA-KGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIK-DPTW 541
Query: 2442 INGNPNPITTVREIAAGGSRKLIDCKAEGIPT--PRVLWAFPEGVVLPAPYYGNRITVHG 2499
I P R GS +CK + T VLW + LP+ R TV
Sbjct: 542 IVKQPEYAVVQR-----GSMVSFECKVKHDHTLSLTVLW-LKDNRELPS---DERFTV-D 591
Query: 2500 NGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHT 2559
L + + DS C+A L+V++ + + P ++T +
Sbjct: 592 KDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVD-----VPNPPFDLELTDQLDKS 646
Query: 2560 ISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHIS--GLSSVDAGAYRCV 2617
+ L+ + + + D L + G + LS ++R +
Sbjct: 647 VQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVM 706
Query: 2618 ARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGR----FSWTL 2673
A N+ G + L EA++QY S E K P G G +W
Sbjct: 707 AVNSIGKS---------LPSEASEQYLTKAS----EPDKNPTAVEGLGSEPDNLVITWKP 753
Query: 2674 PNGMHLEGPQTLGRVS 2689
NG GP +VS
Sbjct: 754 LNGFESNGPGLQYKVS 769
Score = 117 bits (294), Expect = 1e-25
Identities = 127/525 (24%), Positives = 210/525 (40%), Gaps = 69/525 (13%)
Query: 2345 PATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWL-SPTNKVIPTSSEKYQIYQDGTL 2403
P TI ++ + + + + CEAKG+P P +W + T+ I GTL
Sbjct: 39 PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTL 98
Query: 2404 LIQ-----KAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAA- 2457
+I KA+ + G Y C RN G V ++ V+P + +P+ T ++
Sbjct: 99 IINIMSEGKAETYE-GVYQCTARNERGA---AVSNNIVVRPSR-----SPLWTKEKLEPI 149
Query: 2458 ---GGSRKLIDCKAE-GIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDS 2513
G ++ C+ G+P P + W LP R++ NG L ++ D+
Sbjct: 150 TLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQ---SERVSQGLNGDLYFSNVLPEDT 206
Query: 2514 VQ-LVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKIT------------------- 2553
+ +C AR + Q ++ + +D I+ ++
Sbjct: 207 REDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLT 266
Query: 2554 ---------AMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHIS 2604
+ G+ +SL C A G PTP + W +G L + + + + K ++H+S
Sbjct: 267 PEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGM-LPKNRTVYKNFEKTLQIIHVS 325
Query: 2605 GLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGA 2664
D+G Y+C+A+NA G +S++V P NLV + GE L C G
Sbjct: 326 ---EADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLV-LSPGEDGTLICRANGN 381
Query: 2665 GQGRFSWTLPNGMHLE-GPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTS 2723
+ R SW L NG+ +E P R +D T+ Y C EYG + +
Sbjct: 382 PKPRISW-LTNGVPIEIAPDDPSRK--IDGDTIIFSNVQERSSAVYQCNASNEYGYLLAN 438
Query: 2724 IPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARL 2783
V V+A PPRI + + L+C G P I W K + L
Sbjct: 439 AFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEW-------FKGAKGSAL 491
Query: 2784 YGNRF-LHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ + + LH G+L I A + G Y C+A+N LG ++ +
Sbjct: 492 HEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEI 536
Score = 103 bits (258), Expect = 2e-21
Identities = 109/389 (28%), Positives = 159/389 (40%), Gaps = 35/389 (8%)
Query: 1875 CEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH 1934
C A G P P + W K G L T + FE TL I V D G Y C A N
Sbjct: 286 CIAEGLPTPIIYWAK-EDGMLPKNRTVYKNFEK----TLQIIHVSEADSGNYQCIAKNAL 340
Query: 1935 GLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQT 1994
G + SV V+ + Q++ + G+ + C A G P P+ISW+ V
Sbjct: 341 GAIHHTI--SVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWL--TNGVPIE 396
Query: 1995 VSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKL 2054
++P + + + T+ VY+C ASN G ++V A PP I
Sbjct: 397 IAPDDPSRKI-DGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPAN 455
Query: 2055 ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVF-PNGTLYIRNLA 2113
+ + C +PLP++ W G LH +++V NGTL I +A
Sbjct: 456 TLYQVIANRPALLDCAFFGSPLPTIEWFKG-----AKGSALHEDIYVLHENGTLEI-PVA 509
Query: 2114 PKDS-GRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASG 2172
KDS G Y CVA N +G A+ V L ++ + P V+ G + +C
Sbjct: 510 QKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVK----QPEYAVVQRGSMVSFECKVKH 565
Query: 2173 DPW--PRILWRLPSKRM-IDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVAR---NK 2226
D +LW ++ + D F+ D LVV V+D D+G Y CVA +
Sbjct: 566 DHTLSLTVLWLKDNRELPSDERFTVD-------KDHLVVADVSDDDSGTYTCVANTTLDS 618
Query: 2227 VGDDYVVLKVDVVMKPAKIEHKEENDHKV 2255
V V+ VDV P +E ++ D V
Sbjct: 619 VSASAVLSVVDVPNPPFDLELTDQLDKSV 647
Score = 82.8 bits (203), Expect = 4e-15
Identities = 72/283 (25%), Positives = 112/283 (39%), Gaps = 17/283 (6%)
Query: 1859 SPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKV 1918
+PQ + ++ D C A G PKP ++W + P+ ++ + T++ V
Sbjct: 360 APQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKID---GDTIIFSNV 416
Query: 1919 QVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTP 1978
Q + Y C ASN +G ++V + P+IL V ++C G+P
Sbjct: 417 QERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSP 476
Query: 1979 APQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAI 2038
P I W + + + E LHEN TL I A G Y CVA N G +
Sbjct: 477 LPTIEWF----KGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEV 532
Query: 2039 RLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPS--VRWVLGDGTQIRPSQFLH 2096
L + ++ Q E + G + C K S V W L D ++ PS
Sbjct: 533 HLEIKDPTWIVKQP--EYAVVQRGSMVSFECKVKHDHTLSLTVLW-LKDNREL-PSD--- 585
Query: 2097 GNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNV 2139
F L + +++ DSG Y CVA + S + L+V
Sbjct: 586 -ERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSV 627
Score = 80.5 bits (197), Expect = 2e-14
Identities = 143/629 (22%), Positives = 234/629 (37%), Gaps = 77/629 (12%)
Query: 2239 VMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRT 2298
+++P I + D+ + ++ + C A G P P SW+ + D T
Sbjct: 36 LVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRN-----GTHFDIDKDPLVT 90
Query: 2299 KRYVVFNNGTLYFNEV--GMRE--EGDYTCFAENQVGKD-EMRVRVKVVTAPATIRNKTY 2353
+ GTL N + G E EG Y C A N+ G + V+ +P + K
Sbjct: 91 MKP---GTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLE 147
Query: 2354 LAVQVPYGDVVTVACEAK-GEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSD 2412
+ + G + + C G P P + W+ + + +P SE+ +G L D
Sbjct: 148 -PITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLP-QSERVSQGLNGDLYFSNVLPED 205
Query: 2413 SG-NYTCLVRNSAGE---------------DRKTVWIHVNVQPPKINGNPN-----PITT 2451
+ +Y C R + + D I N+ + G + P
Sbjct: 206 TREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFL 265
Query: 2452 VREIAAGGSRKL------IDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGN--GSL 2503
E A +L ++C AEG+PTP + WA +G+ LP NR TV+ N +L
Sbjct: 266 TPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGM-LPK----NR-TVYKNFEKTL 319
Query: 2504 DIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLN 2563
I + ++DS C+A+N G + T+ ++ + + + G +L
Sbjct: 320 QIIHVSEADSGNYQCIAKNALGA----IHHTISVRVKAAPYWITAPQNLVLSPGEDGTLI 375
Query: 2564 CSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADG-MLHISGLSSVDAGAYRCVARNAA 2622
C A G P P + W L NG ++ K DG + S + + Y+C A N
Sbjct: 376 CRANGNPKPRISW-LTNGVPIEIAPDDPS--RKIDGDTIIFSNVQERSSAVYQCNASNEY 432
Query: 2623 GHTERLVSLKVGLKPEANKQYHN-LVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEG 2681
G+ + V +P N L +I L C G+ W +G
Sbjct: 433 GYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWF----KGAKG 488
Query: 2682 PQTLGRVSLL-DNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPT 2740
+ +L +NGTL + A GTY C + G + + + I P I +P
Sbjct: 489 SALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVH-LEIKDPTWIVKQPE 547
Query: 2741 PVIYTRPGNTVKLNCMAMGIPKADIT--WELPDKSHLKAGVQARLYGNRFLHPQGSLTIQ 2798
+ R G+ V C +T W L D L + RF + L +
Sbjct: 548 YAVVQR-GSMVSFECKVKHDHTLSLTVLW-LKDNRELPSD-------ERFTVDKDHLVVA 598
Query: 2799 HATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
+ D+G Y C+A L S S + + V
Sbjct: 599 DVSDDDSGTYTCVANTTLDSVSASAVLSV 627
Score = 69.3 bits (168), Expect = 5e-11
Identities = 62/234 (26%), Positives = 104/234 (44%), Gaps = 16/234 (6%)
Query: 1817 SFITSSVQS-SGSFHQSSSKFFAGGPPASKFWS-LGEKPQILTKSPQTVSVTAETDTVFP 1874
+ I S+VQ S + +Q ++ G A+ F + L E P+ILT + V A +
Sbjct: 410 TIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLD 469
Query: 1875 CEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH 1934
C G P P + W K + G+ + + + + +NGTL I Q G Y C A N
Sbjct: 470 CAFFGSPLPTIEWFKGAKGSALHEDI----YVLHENGTLEIPVAQKDSTGTYTCVARNKL 525
Query: 1935 GLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAK--GTPAPQISWIFPDRRVW 1992
G+ + V L ++ P + + V G ++ EC K T + + W+ +R +
Sbjct: 526 GMAKNEVHLE--IKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL- 582
Query: 1993 QTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALP 2046
P + R T+ ++ L + + S D G Y CVA+ + S + L V +P
Sbjct: 583 ----PSDERFTVDKDH-LVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVP 631
Score = 52.8 bits (125), Expect = 5e-06
Identities = 46/190 (24%), Positives = 79/190 (41%), Gaps = 11/190 (5%)
Query: 469 RQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDP 528
+ +R R + P G + L G L C + +P I+W DG + K
Sbjct: 255 KSSRERPPTFLTPEGNASNKEE-LRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYK 313
Query: 529 DSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIG 588
+ + + L+I + +DSG YQCIA ++ + + + + V+ + +
Sbjct: 314 NFEKT------LQIIHVSEADSGNYQCIA--KNALGAIHHTISVRVKAAPYWITAPQNLV 365
Query: 589 KNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGY 648
+PGE TL C A P+ +SW+ I ++A + T+ VQ S
Sbjct: 366 LSPGEDGTLICRANGNPKPRISWLTNGVPI--EIAPDDPSRKIDGDTIIFSNVQERSSAV 423
Query: 649 YRCVAVNQQG 658
Y+C A N+ G
Sbjct: 424 YQCNASNEYG 433
Score = 43.9 bits (102), Expect = 0.002
Identities = 44/164 (26%), Positives = 63/164 (38%), Gaps = 15/164 (9%)
Query: 499 LSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIA- 557
L C + P I W L +G ++ DDP K + + +++ S +YQC A
Sbjct: 374 LICRANGNPKPRISW-LTNGVPIEIAPDDPSRK---IDGDTIIFSNVQERSSAVYQCNAS 429
Query: 558 -QVRDEMDRMVYRVLVQSPST-QPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPN 615
+ + VL + P PA I P L C P + W
Sbjct: 430 NEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPA---LLDCAFFGSPLPTIEWF--- 483
Query: 616 RRIINDLANTSHVYML-PNGTLSIPKVQVSDSGYYRCVAVNQQG 658
+ A +Y+L NGTL IP Q +G Y CVA N+ G
Sbjct: 484 -KGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLG 526
Score = 39.7 bits (91), Expect = 0.043
Identities = 27/82 (32%), Positives = 37/82 (45%), Gaps = 14/82 (17%)
Query: 592 GESVTLPCNALAIPEAHLSW-----ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDS 646
G ++L C A +P + W +LP R VY TL I V +DS
Sbjct: 279 GNVLSLECIAEGLPTPIIYWAKEDGMLPKNRT---------VYKNFEKTLQIIHVSEADS 329
Query: 647 GYYRCVAVNQQGADHFTVGITV 668
G Y+C+A N GA H T+ + V
Sbjct: 330 GNYQCIAKNALGAIHHTISVRV 351
Score = 37.0 bits (84), Expect = 0.28
Identities = 37/166 (22%), Positives = 65/166 (39%), Gaps = 16/166 (9%)
Query: 491 VLEGGPCQLSCNVKASESPSIFWVL-PDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
V+ P L C S P+I W GS L + + + +G L I +
Sbjct: 460 VIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDI------YVLHENGTLEIPVAQKDS 513
Query: 550 SGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHL 609
+G Y C+A+ + M + + ++ P+ + + + + G V+ C L
Sbjct: 514 TGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR--GSMVSFECKVKHDHTLSL 571
Query: 610 S--WILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
+ W+ NR + +D + + L + V DSG Y CVA
Sbjct: 572 TVLWLKDNRELPSD-----ERFTVDKDHLVVADVSDDDSGTYTCVA 612
Score = 34.3 bits (77), Expect = 1.8
Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 11/95 (11%)
Query: 571 LVQSPS-TQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVY 629
LVQ P+ TQ + KD + +P E++ + C A P SW D+ V
Sbjct: 36 LVQPPTITQQSPKDYII---DPRENIVIQCEAKGKPPPSFSWTRNGTHF--DIDKDPLVT 90
Query: 630 MLP-NGTLSIPKVQVSDS----GYYRCVAVNQQGA 659
M P GTL I + + G Y+C A N++GA
Sbjct: 91 MKPGTGTLIINIMSEGKAETYEGVYQCTARNERGA 125
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 140 bits (354), Expect = 1e-32
Identities = 136/500 (27%), Positives = 215/500 (43%), Gaps = 54/500 (10%)
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTG-ALMTPNTRIQRFEVLKNG 1911
P+I+ + P + E T+ PC A G+P+P + W K A + + R R +L +G
Sbjct: 64 PRIVEQPPDLLVSRGEPATL-PCRAEGRPRPNIEWYKNGARVATVREDPRAHRL-LLPSG 121
Query: 1912 TLVIRKV-----QVQDRGQYMCTASN-LHGLDRMVVLLSVTVQQPQILASHYQDVTVYLG 1965
L ++ D G Y C A N L L V V + S +V V +G
Sbjct: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP-GNVVVAVG 180
Query: 1966 DTIAMECL-AKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYK 2024
+ +EC+ +G P P +SW R+ + EGRIT+ + L + SD G+Y
Sbjct: 181 EPAVLECVPPRGHPEPSVSW----RKDGARLKEEEGRITIRGGK-LMMSHTLKSDAGMYV 235
Query: 2025 CVASNAAG-ADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVL 2083
CVASN AG +S A + V P + + N + + C K P P +RW
Sbjct: 236 CVASNMAGERESAAAEVMVLERPSFLRRP--VNQVVLADAPVTFLCEVKGDPPPRLRWRK 293
Query: 2084 GDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
DG + G + + +L+I +++ +D G Y CVA N VG A + L+V
Sbjct: 294 EDG------ELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPP 347
Query: 2144 ANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDS-----RI 2198
T P+ G ++ C G+P P I W+ +++ LF S R
Sbjct: 348 QLV----TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVL--LFPSQSLQPTGRF 401
Query: 2199 KVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEH------KEEND 2252
V G L + +V DAG Y+C A + G ++ K + +K A ++ + +
Sbjct: 402 SVSPRGQLNITAVQRGDAGYYVCQAVSVAGS--ILAKALLEIKGASLDGLPPVILQGPAN 459
Query: 2253 HKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFN 2312
+ G + + C TG P P + W DG ++Q DD ++ NGTLY
Sbjct: 460 QTLVLGSSVWLPCRVTGNPQPSVRWK-KDG----QWLQGDD-----LQFKTMANGTLYIA 509
Query: 2313 EVGMREEGDYTCFAENQVGK 2332
V + G Y+C A++ G+
Sbjct: 510 NVQEMDMGFYSCVAKSSTGE 529
Score = 137 bits (346), Expect = 1e-31
Identities = 132/506 (26%), Positives = 207/506 (40%), Gaps = 59/506 (11%)
Query: 2044 ALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFP 2103
A+P ++ Q ++ + G + C A+ P P++ W + + + P
Sbjct: 62 AMPRIVEQPP--DLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLP 119
Query: 2104 NGTLYIRNL-----APKDSGRYECVAANLVGSAR-RTVQLNVQRAAANARITGTSPRRTD 2157
+G L+ + A D G Y CVA N +G+A R L V + R SP
Sbjct: 120 SGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFR---QSPGNVV 176
Query: 2158 VRYGGTLKLDC-SASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDA 2216
V G L+C G P P + WR R+ + + RI + G L++ DA
Sbjct: 177 VAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEE----EGRITI-RGGKLMMSHTLKSDA 231
Query: 2217 GDYLCVARNKVGD-DYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEI 2275
G Y+CVA N G+ + +V V+ +P+ + + + V + C G P P +
Sbjct: 232 GMYVCVASNMAGERESAAAEVMVLERPSFL--RRPVNQVVLADAPVTFLCEVKGDPPPRL 289
Query: 2276 SWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEM 2335
W DG L T RY + ++ +L+ V +EG YTC AEN VG+ E
Sbjct: 290 RWRKEDGELP------------TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEA 337
Query: 2336 RVRVKVVTAPATI-RNKTYLAVQVPYGDVVTVACEAKGEPMPKVTW--------LSPTNK 2386
+ V P + + + +A G+ V CE KG P P + W L P+
Sbjct: 338 SGSLSVHVPPQLVTQPQDQMAAP---GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQS 394
Query: 2387 VIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHV-----NVQPPK 2441
+ PT ++ + G L I QR D+G Y C + AG + + + PP
Sbjct: 395 LQPTG--RFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPV 452
Query: 2442 INGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNG 2501
I P T V GS + C+ G P P V W +G L + NG
Sbjct: 453 ILQGPANQTLVL-----GSSVWLPCRVTGNPQPSVRWK-KDGQWLQGD--DLQFKTMANG 504
Query: 2502 SLDIRSLRKSDSVQLVCMARNEGGEA 2527
+L I ++++ D C+A++ GEA
Sbjct: 505 TLYIANVQEMDMGFYSCVAKSSTGEA 530
Score = 126 bits (317), Expect = 3e-28
Identities = 128/481 (26%), Positives = 197/481 (40%), Gaps = 48/481 (9%)
Query: 2358 VPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQ---IYQDGTLLIQKA-----Q 2409
V G+ T+ C A+G P P + W +V + + G L +
Sbjct: 75 VSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRA 134
Query: 2410 RSDSGNYTCLVRNSAGEDR-KTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDC-K 2467
R D G YTC+ RN G + + V V +P + + A G +++C
Sbjct: 135 RPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNV-----VVAVGEPAVLECVP 189
Query: 2468 AEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEA 2527
G P P V W +G L RIT+ G G L + KSD+ VC+A N GE
Sbjct: 190 PRGHPEPSVSWR-KDGARLKEEE--GRITIRG-GKLMMSHTLKSDAGMYVCVASNMAGER 245
Query: 2528 RLILQLTVLEPMEKPIF-HDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQS 2586
++ +E+P F P+++ + A A ++ C G P P L W +G +L +
Sbjct: 246 ESAAAEVMV--LERPSFLRRPVNQVVLADA--PVTFLCEVKGDPPPRLRWRKEDG-ELPT 300
Query: 2587 GQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNL 2646
G R+ ++D L I +S+ D G Y CVA N+ G E SL V + P+ Q +
Sbjct: 301 G----RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQ 356
Query: 2647 VSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGP----QTLGRVSLLDNGTLTVREAS 2702
++ GE++ C G W L P Q GR S+ G L +
Sbjct: 357 MA-APGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQ 415
Query: 2703 VFDRGTYVCRMETEYGPSVTSIPVIVI------AYPPRITSEPTPVIYTRPGNTVKLNCM 2756
D G YVC+ + G S+ + ++ I PP I P G++V L C
Sbjct: 416 RGDAGYYVCQAVSVAG-SILAKALLEIKGASLDGLPPVILQGPANQTLVL-GSSVWLPCR 473
Query: 2757 AMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNIL 2816
G P+ + W+ + +Q + N G+L I + + D GFY C+AK+
Sbjct: 474 VTGNPQPSVRWKKDGQWLQGDDLQFKTMAN------GTLYIANVQEMDMGFYSCVAKSST 527
Query: 2817 G 2817
G
Sbjct: 528 G 528
Score = 121 bits (304), Expect = 9e-27
Identities = 134/511 (26%), Positives = 201/511 (39%), Gaps = 50/511 (9%)
Query: 1959 DVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTV--SPVEGRITLHENRTLSIK--- 2013
D+ V G+ + C A+G P P I W RV TV P R+ L +
Sbjct: 72 DLLVSRGEPATLPCRAEGRPRPNIEWYKNGARV-ATVREDPRAHRLLLPSGALFFPRIVH 130
Query: 2014 -EASFSDRGVYKCVASNAAGAD-SLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTA 2071
+ D GVY CVA N GA S L VA L Q N+ + G + C
Sbjct: 131 GRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP-GNVVVAVGEPAVLECVP 189
Query: 2072 -KAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVG- 2129
+ P PSV W DG +++ + G L + + D+G Y CVA+N+ G
Sbjct: 190 PRGHPEPSVSW-RKDGARLKEEE----GRITIRGGKLMMSHTLKSDAGMYVCVASNMAGE 244
Query: 2130 --SARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRM 2187
SA V + ++R + R P V + C GDP PR+ WR +
Sbjct: 245 RESAAAEVMV-LERPSFLRR-----PVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL 298
Query: 2188 IDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEH 2247
R ++ ++ +L + V+ +D G Y CVA N VG + V + P +
Sbjct: 299 PTG------RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQ 352
Query: 2248 KEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG 2307
+ D G + C G P P I W +GS V F S T R+ V G
Sbjct: 353 PQ--DQMAAPGESVAFQCETKGNPPPAIFWQ-KEGSQVLLF--PSQSLQPTGRFSVSPRG 407
Query: 2308 TLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVP------YG 2361
L V + G Y C A + G + +++ A++ + +Q P G
Sbjct: 408 QLNITAVQRGDAGYYVCQAVSVAGSILAKALLEI--KGASLDGLPPVILQGPANQTLVLG 465
Query: 2362 DVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVR 2421
V + C G P P V W + + +++ +GTL I Q D G Y+C+ +
Sbjct: 466 SSVWLPCRVTGNPQPSVRW-KKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAK 524
Query: 2422 NSAGEDRKTVWIH------VNVQPPKINGNP 2446
+S GE + W+ V+ PP +P
Sbjct: 525 SSTGEATWSGWLKMREDWGVSPDPPTEPSSP 555
Score = 118 bits (295), Expect = 9e-26
Identities = 96/297 (32%), Positives = 129/297 (43%), Gaps = 38/297 (12%)
Query: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910
E+P L + P V A+ F CE G P P + W K G L T R+E+ +
Sbjct: 256 ERPSFLRR-PVNQVVLADAPVTFLCEVKGDPPPRLRWRK-EDGELPTG-----RYEIRSD 308
Query: 1911 GTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAM 1970
+L I V +D G Y C A N G R S++V P L + QD G+++A
Sbjct: 309 HSLWIGHVSAEDEGTYTCVAENSVG--RAEASGSLSVHVPPQLVTQPQDQMAAPGESVAF 366
Query: 1971 ECLAKGTPAPQISW--------IFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGV 2022
+C KG P P I W +FP + + T GR ++ L+I D G
Sbjct: 367 QCETKGNPPPAIFWQKEGSQVLLFPSQSLQPT-----GRFSVSPRGQLNITAVQRGDAGY 421
Query: 2023 YKCVASNAAGADSLAIRLHVA-----ALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLP 2077
Y C A + AG+ L + LPPVI Q N +L G S+ + C P P
Sbjct: 422 YVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGP-ANQTLVLGSSVWLPCRVTGNPQP 480
Query: 2078 SVRWVLGDGTQIRPSQFLHGNLFVF---PNGTLYIRNLAPKDSGRYECVAANLVGSA 2131
SVRW + Q+L G+ F NGTLYI N+ D G Y CVA + G A
Sbjct: 481 SVRWK-------KDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
Score = 117 bits (293), Expect = 2e-25
Identities = 125/488 (25%), Positives = 194/488 (39%), Gaps = 42/488 (8%)
Query: 2252 DHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYF 2311
D V G + C A G P P I W +G+ V + ++ D R ++ +G L+F
Sbjct: 72 DLLVSRGEPATLPCRAEGRPRPNIEW-YKNGARVAT-VREDPRAHR----LLLPSGALFF 125
Query: 2312 NEV--GMR---EEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTV 2366
+ G R +EG YTC A N +G R V ++ V V G+ +
Sbjct: 126 PRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVL 185
Query: 2367 AC-EAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAG 2425
C +G P P V+W ++ E + G L++ +SD+G Y C+ N AG
Sbjct: 186 ECVPPRGHPEPSVSWRKDGARL--KEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAG 243
Query: 2426 EDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVV 2485
E + ++ P P V ++ + C+ +G P PR+ W +G
Sbjct: 244 ERESAAAEVMVLERPSFLRRP-----VNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGE- 297
Query: 2486 LPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFH 2545
LP R + + SL I + D C+A N G A L+V P + +
Sbjct: 298 LPT----GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQ--LVT 351
Query: 2546 DPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL----QSGQQLQRFYHKADGML 2601
P + A G +++ C G P P++ W L QS Q RF G L
Sbjct: 352 QPQDQM--AAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQL 409
Query: 2602 HISGLSSVDAGAYRCVARNAAGHTERLVSLKV------GLKPEANKQYHNLVSIINGETL 2655
+I+ + DAG Y C A + AG L++ GL P + N ++ G ++
Sbjct: 410 NITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVL-GSSV 468
Query: 2656 KLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMET 2715
LPC G Q W +G L+G + + NGTL + D G Y C ++
Sbjct: 469 WLPCRVTGNPQPSVRWK-KDGQWLQGDDL--QFKTMANGTLYIANVQEMDMGFYSCVAKS 525
Query: 2716 EYGPSVTS 2723
G + S
Sbjct: 526 STGEATWS 533
Score = 85.9 bits (211), Expect = 5e-16
Identities = 100/387 (25%), Positives = 151/387 (39%), Gaps = 51/387 (13%)
Query: 2455 IAAGGSRKLIDCKAEGIPTPRVLWAFPEG--------------VVLPAPYYGNRITVHGN 2500
+ + G + C+AEG P P + W + G ++LP+ VHG
Sbjct: 74 LVSRGEPATLPCRAEGRPRPNIEW-YKNGARVATVREDPRAHRLLLPSGALFFPRIVHG- 131
Query: 2501 GSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEK---ITAMAG 2557
R R + V C+ARN G A + +E + D + + G
Sbjct: 132 -----RRARPDEGVY-TCVARNYLGAAA-----SRNASLEVAVLRDDFRQSPGNVVVAVG 180
Query: 2558 HTISLNC-SAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKAD---GMLHISGLSSVDAGA 2613
L C G P PS+ W + G +L+ + G L +S DAG
Sbjct: 181 EPAVLECVPPRGHPEPSVSW-------RKDGARLKEEEGRITIRGGKLMMSHTLKSDAGM 233
Query: 2614 YRCVARNAAGHTERLVSLKVGL-KPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWT 2672
Y CVA N AG E + + L +P ++ N V + + L C G R W
Sbjct: 234 YVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFL-CEVKGDPPPRLRWR 292
Query: 2673 LPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYP 2732
+G E P GR + + +L + S D GTY C E G + S + + P
Sbjct: 293 KEDG---ELPT--GRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEAS-GSLSVHVP 346
Query: 2733 PRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRF-LHP 2791
P++ ++P + PG +V C G P I W+ L Q+ RF + P
Sbjct: 347 PQLVTQPQDQM-AAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSP 405
Query: 2792 QGSLTIQHATQRDAGFYKCMAKNILGS 2818
+G L I + DAG+Y C A ++ GS
Sbjct: 406 RGQLNITAVQRGDAGYYVCQAVSVAGS 432
Score = 68.2 bits (165), Expect = 1e-10
Identities = 55/205 (26%), Positives = 83/205 (40%), Gaps = 28/205 (13%)
Query: 470 QARGRSWVMIEPSGAVQ-RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDD- 527
+A G V + P Q +DQ G C K + P+IFW +L P
Sbjct: 336 EASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSL 395
Query: 528 -PDSKFSILSSGWLRIKSMEPSDSGLYQCIA-------------QVRDEMDRMVYRVLVQ 573
P +FS+ G L I +++ D+G Y C A +++ + V++Q
Sbjct: 396 QPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQ 455
Query: 574 SPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPN 633
P+ Q T+ +G SV LPC P+ + W + + D + N
Sbjct: 456 GPANQ-----TLVLGS----SVWLPCRVTGNPQPSVRWKKDGQWLQGD---DLQFKTMAN 503
Query: 634 GTLSIPKVQVSDSGYYRCVAVNQQG 658
GTL I VQ D G+Y CVA + G
Sbjct: 504 GTLYIANVQEMDMGFYSCVAKSSTG 528
Score = 65.9 bits (159), Expect = 6e-10
Identities = 53/200 (26%), Positives = 80/200 (40%), Gaps = 21/200 (10%)
Query: 469 RQARGRSWVMIEPSGAVQR--DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMD 526
R++ +++E ++R +Q VL P C VK P + W DG +
Sbjct: 245 RESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL------ 298
Query: 527 DPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPS---TQPAEKD 583
P ++ I S L I + D G Y C+A+ + V P TQP ++
Sbjct: 299 -PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQM 357
Query: 584 TVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRII----NDLANTSHVYMLPNGTLSIP 639
PGESV C P + W +++ L T + P G L+I
Sbjct: 358 AA-----PGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNIT 412
Query: 640 KVQVSDSGYYRCVAVNQQGA 659
VQ D+GYY C AV+ G+
Sbjct: 413 AVQRGDAGYYVCQAVSVAGS 432
Score = 50.4 bits (119), Expect = 2e-05
Identities = 53/203 (26%), Positives = 79/203 (38%), Gaps = 25/203 (12%)
Query: 1743 LGVTRRPQIPTSPAPVMRERKVIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGS---- 1798
L V PQ+ T P +++ PG + G P P + Q GS
Sbjct: 341 LSVHVPPQLVTQP----QDQMAAPGESVAFQCETK-----GNPPPAIFW--QKEGSQVLL 389
Query: 1799 -PSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPAS-----KFWSLGEK 1852
PS +LQ S + IT+ + ++ + AG A K SL
Sbjct: 390 FPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGL 449
Query: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
P ++ + P ++ + PC TG P+P V W K G + + +F+ + NGT
Sbjct: 450 PPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKK--DGQWLQGDD--LQFKTMANGT 505
Query: 1913 LVIRKVQVQDRGQYMCTASNLHG 1935
L I VQ D G Y C A + G
Sbjct: 506 LYIANVQEMDMGFYSCVAKSSTG 528
Score = 42.4 bits (98), Expect = 0.007
Identities = 25/74 (33%), Positives = 34/74 (45%), Gaps = 6/74 (8%)
Query: 592 GESVTLPCNALAIPEAHLSWILPNRRIINDLAN-TSHVYMLPNGTLSIPKV-----QVSD 645
GE TLPC A P ++ W R+ + +H +LP+G L P++ D
Sbjct: 78 GEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPD 137
Query: 646 SGYYRCVAVNQQGA 659
G Y CVA N GA
Sbjct: 138 EGVYTCVARNYLGA 151
Score = 40.0 bits (92), Expect = 0.033
Identities = 30/91 (32%), Positives = 43/91 (47%), Gaps = 8/91 (8%)
Query: 2733 PRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQ 2792
PRI +P ++ +R G L C A G P+ +I W A V+ +R L P
Sbjct: 64 PRIVEQPPDLLVSR-GEPATLPCRAEGRPRPNIEWY--KNGARVATVREDPRAHRLLLPS 120
Query: 2793 GSL---TIQHA--TQRDAGFYKCMAKNILGS 2818
G+L I H + D G Y C+A+N LG+
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGA 151
Score = 40.0 bits (92), Expect = 0.033
Identities = 43/181 (23%), Positives = 68/181 (37%), Gaps = 19/181 (10%)
Query: 488 DQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEP 547
D V G P L C + P+I W +G+ + +DP + +L SG L +
Sbjct: 72 DLLVSRGEPATLPCRAEGRPRPNIEWY-KNGARVATVREDPRAHRLLLPSGALFFPRIVH 130
Query: 548 S-----DSGLYQCIAQ----VRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLP 598
D G+Y C+A+ + + +++ Q V +G E L
Sbjct: 131 GRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVG----EPAVLE 186
Query: 599 C-NALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQ 657
C PE +SW R+ + + + G L + SD+G Y CVA N
Sbjct: 187 CVPPRGHPEPSVSWRKDGARLKEEEGRIT----IRGGKLMMSHTLKSDAGMYVCVASNMA 242
Query: 658 G 658
G
Sbjct: 243 G 243
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 119,968,515
Number of Sequences: 37866
Number of extensions: 6209999
Number of successful extensions: 42543
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 408
Number of HSP's successfully gapped in prelim test: 512
Number of HSP's that attempted gapping in prelim test: 17388
Number of HSP's gapped (non-prelim): 10778
length of query: 2828
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2708
effective length of database: 13,703,598
effective search space: 37109343384
effective search space used: 37109343384
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.