BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|139394648 DNA polymerase theta [Homo sapiens] (2590 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|139394648 DNA polymerase theta [Homo sapiens] 5136 0.0 gi|110556640 DNA helicase HEL308 [Homo sapiens] 416 e-115 gi|112420958 DNA-directed DNA polymerase nu [Homo sapiens] 230 2e-59 gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD prote... 136 2e-31 gi|40217847 activating signal cointegrator 1 complex subunit 3-l... 136 2e-31 gi|130484567 HFM1 protein [Homo sapiens] 135 5e-31 gi|76880486 activating signal cointegrator 1 complex subunit 3 i... 120 1e-26 gi|193211480 superkiller viralicidic activity 2-like 2 [Homo sap... 107 2e-22 gi|67782311 superkiller viralicidic activity 2-like homolog [Hom... 90 3e-17 gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sap... 76 5e-13 gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Hom... 71 2e-11 gi|14251212 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 [Homo sapi... 49 5e-05 gi|116812616 RecQ protein-like 4 [Homo sapiens] 49 6e-05 gi|4503529 eukaryotic translation initiation factor 4A isoform 1... 47 2e-04 gi|83700235 eukaryotic translation initiation factor 4A2 [Homo s... 46 4e-04 gi|110735439 Werner syndrome protein [Homo sapiens] 45 0.001 gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent... 45 0.001 gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I [... 43 0.004 gi|7661920 eukaryotic translation initiation factor 4A, isoform ... 43 0.004 gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo sapi... 41 0.013 gi|13129006 nucleolar protein GU2 [Homo sapiens] 41 0.013 gi|21071032 DEAD-box protein abstrakt [Homo sapiens] 41 0.013 gi|34740327 zinc finger protein 804A [Homo sapiens] 40 0.039 gi|149408122 RNA helicase LGP2 [Homo sapiens] 39 0.051 gi|27886568 interferon induced with helicase C domain 1 [Homo sa... 39 0.051 gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens] 39 0.067 gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens] 39 0.067 gi|74048554 cancer susceptibility candidate 5 isoform 2 [Homo sa... 39 0.087 gi|40068059 CBF1 interacting corepressor [Homo sapiens] 38 0.11 gi|51339291 sterile alpha motif domain containing 9-like [Homo s... 38 0.11 >gi|139394648 DNA polymerase theta [Homo sapiens] Length = 2590 Score = 5136 bits (13322), Expect = 0.0 Identities = 2590/2590 (100%), Positives = 2590/2590 (100%) Query: 1 MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT 60 MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT Sbjct: 1 MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT 60 Query: 61 VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG 120 VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG Sbjct: 61 VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG 120 Query: 121 KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH 180 KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH Sbjct: 121 KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH 180 Query: 181 FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI 240 FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI Sbjct: 181 FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI 240 Query: 241 TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN 300 TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN Sbjct: 241 TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN 300 Query: 301 SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE 360 SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE Sbjct: 301 SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE 360 Query: 361 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL 420 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL Sbjct: 361 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL 420 Query: 421 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR 480 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR Sbjct: 421 TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR 480 Query: 481 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV 540 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV Sbjct: 481 AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV 540 Query: 541 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA 600 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA Sbjct: 541 GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA 600 Query: 601 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED 660 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED Sbjct: 601 SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED 660 Query: 661 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF 720 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF Sbjct: 661 WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF 720 Query: 721 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ 780 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ Sbjct: 721 TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ 780 Query: 781 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK 840 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK Sbjct: 781 FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK 840 Query: 841 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP 900 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP Sbjct: 841 SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP 900 Query: 901 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN 960 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN Sbjct: 901 CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN 960 Query: 961 KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS 1020 KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS Sbjct: 961 KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS 1020 Query: 1021 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED 1080 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED Sbjct: 1021 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED 1080 Query: 1081 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG 1140 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG Sbjct: 1081 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG 1140 Query: 1141 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS 1200 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS Sbjct: 1141 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS 1200 Query: 1201 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS 1260 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS Sbjct: 1201 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS 1260 Query: 1261 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED 1320 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED Sbjct: 1261 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED 1320 Query: 1321 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH 1380 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH Sbjct: 1321 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH 1380 Query: 1381 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS 1440 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS Sbjct: 1381 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS 1440 Query: 1441 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV 1500 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV Sbjct: 1441 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV 1500 Query: 1501 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE 1560 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE Sbjct: 1501 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE 1560 Query: 1561 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL 1620 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL Sbjct: 1561 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL 1620 Query: 1621 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE 1680 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE Sbjct: 1621 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE 1680 Query: 1681 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI 1740 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI Sbjct: 1681 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI 1740 Query: 1741 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS 1800 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS Sbjct: 1741 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS 1800 Query: 1801 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR 1860 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR Sbjct: 1801 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR 1860 Query: 1861 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE 1920 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE Sbjct: 1861 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE 1920 Query: 1921 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI 1980 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI Sbjct: 1921 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI 1980 Query: 1981 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH 2040 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH Sbjct: 1981 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH 2040 Query: 2041 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE 2100 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE Sbjct: 2041 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE 2100 Query: 2101 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS 2160 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS Sbjct: 2101 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS 2160 Query: 2161 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL 2220 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL Sbjct: 2161 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL 2220 Query: 2221 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM 2280 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM Sbjct: 2221 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM 2280 Query: 2281 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA 2340 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA Sbjct: 2281 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA 2340 Query: 2341 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE 2400 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE Sbjct: 2341 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE 2400 Query: 2401 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR 2460 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR Sbjct: 2401 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR 2460 Query: 2461 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKR 2520 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKR Sbjct: 2461 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKR 2520 Query: 2521 KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA 2580 KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA Sbjct: 2521 KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA 2580 Query: 2581 SWGELKDFDV 2590 SWGELKDFDV Sbjct: 2581 SWGELKDFDV 2590 >gi|110556640 DNA helicase HEL308 [Homo sapiens] Length = 1101 Score = 416 bits (1070), Expect = e-115 Identities = 277/806 (34%), Positives = 440/806 (54%), Gaps = 68/806 (8%) Query: 74 WGLPKAVLEKYHSF-GVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKR 132 + LP V + Y F G++K++EWQ CL L V E KNL+YS PTS GKTLVAE+L+L+ Sbjct: 317 YSLPSKVRDLYAQFKGIEKLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQE 376 Query: 133 VLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTS---PSRHFSSLDIAVC 189 +L RK L ILP+V++ +EK L S E+G V+ Y GS P++ + + Sbjct: 377 LLCCRKDVLMILPYVAIVQEKISGLSSFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIA 436 Query: 190 TIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQA 249 TIE+ + L+N LIE ++D LG+VVVDELHM+G+ RG LE+ L KI Y Sbjct: 437 TIEKGHSLVNSLIETGRIDSLGLVVVDELHMIGEGSRGATLEMTLAKILYT--------- 487 Query: 250 DLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIY--DSSM 307 S QI+GMSATL N+E + +L AE Y + FRPV L E +K+ ++IY DS Sbjct: 488 ------SKTTQIIGMSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYEVDSKA 541 Query: 308 KLVREFEPMLQVKG-------DEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE 360 + F +L K D DH+V+L E I N+S L+FCPSKK CE +A++I + Sbjct: 542 ENGMTFSRLLNYKYSDTLKKMDPDHLVALVTEVI-PNYSCLVFCPSKKNCENVAEMICK- 599 Query: 361 FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSG-LDSVLQKTVPWGVAFHHAG 419 F + + ++KE EV+ L+ + +G L VL++T+P+GVA+HH+G Sbjct: 600 FLSKEYLKH-------------KEKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAYHHSG 646 Query: 420 LTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVG 479 LT +ER ++E A+ G++ + TSTL++GVNLPARRVI+R P L YKQM+G Sbjct: 647 LTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVAKEFLKRNQYKQMIG 706 Query: 480 RAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEII 539 RAGR G+DT+GESILI + +K + + L+ KP+ +C +E T + L +I Sbjct: 707 RAGRAGIDTIGESILILQEKDKQQVLELI---TKPLENCYSHLV-QEFTKGIQTLFLSLI 762 Query: 540 VGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTE 599 +A+ D++ + TF K + ++S+ +E+ + +L E +Q Sbjct: 763 GLKIATNLDDIYHFMNGTFFGVQQK-----VLLKEKSLWEITVES-LRYLTEKGLLQKDT 816 Query: 600 ASDGTEGKVY--HPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPM 657 E Y H T LG A+ ++ A ++ DL++ ++G VLE+ LH++YL TP Sbjct: 817 IYKSEEEVQYNFHITKLGRASFKGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTTPY 876 Query: 658 -FEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIH 716 DW +F + +L + + VA ++GV E F+ + G+ + + ++ + Sbjct: 877 DLVSQCNPDWMIYFRQFSQLSPAEQNVAAILGVSESFIGKKASGQAIGKKVDKN----VV 932 Query: 717 KRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRL-GWHNME 775 R + S VL L+ E + +++K+ RG IQ+L A ++ + F L + Sbjct: 933 NRLYLSFVLYTLLKETNIWTVSEKFNMPRGYIQNLLTGTASFSSCVLHFCEELEEFWVYR 992 Query: 776 LLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARAN----IVEVEV 831 LL + K+LT+ ++ EL L+ V+ + RA+ LY++G+ ++ LA AN + ++ Sbjct: 993 ALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTIDH 1052 Query: 832 ILKNAVP--FKSARKAVDEEEEAVEE 855 + + SA+ + E+ EA++E Sbjct: 1053 LSRRQAKQIVSSAKMLLHEKAEALQE 1078 >gi|112420958 DNA-directed DNA polymerase nu [Homo sapiens] Length = 900 Score = 230 bits (586), Expect = 2e-59 Identities = 180/611 (29%), Positives = 289/611 (47%), Gaps = 116/611 (18%) Query: 1988 DPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGL---NAGSEHSGRY 2044 DP++A WL+DP P+ +V + E + + ++ G S + N Y Sbjct: 348 DPRIAAWLIDPSDATPSFEDLVEKYC--EKSITVKVNSTYGNSSRNIVNQNVRENLKTLY 405 Query: 2045 RASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKH 2104 R +++ L S L+ L +FR +E+P LA++E + I + E E Sbjct: 406 RLTMD----------LCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSA 455 Query: 2105 IMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRG 2164 ++ A+L +E +A+ +AG F TS++ + E+LF +LKL L S R Sbjct: 456 LLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKL-------------HLLSQRNS 502 Query: 2165 IDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFL 2224 + + L + STS+ VLN L+ LHPLP +ILE+R++ + V L C+ Sbjct: 503 LP---RTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLL--ACMKKG- 556 Query: 2225 GMERIYPVSQSHTATGRITFTEPNIQNVPR-DFEIKMPTLVGESPPSQAVGKGLLPMGRG 2283 + + +Q+ T TGR++ PNIQ + + +I P +G Sbjct: 557 SISSTW--NQTGTVTGRLSAKHPNIQGISKHPIQITTPKNF-----------------KG 597 Query: 2284 KYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILAHLS 2343 K K +++PR FV G + LAAD+SQ+ELRIL HLS Sbjct: 598 KEDKILTISPRAM---------------------FVSSKGHTFLAADFSQIELRILTHLS 636 Query: 2344 HDRRLIQVLNTGA--DVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQ 2401 D L+++ DVF ++ ++WK + E V R+Q K++ Y ++YG G + L Sbjct: 637 GDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAAC 696 Query: 2402 MGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRK 2461 +G+ +AA +++SF +Y I F + C + G V +I+GRRR LP I ++ + Sbjct: 697 LGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLR 756 Query: 2462 AHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKRK 2521 A AERQA+N +VQGSAAD+ K+A +++ F + SH T +R Sbjct: 757 AQAERQAVNFVVQGSAADLCKLAMIHV------FTAVAASH-----------TLTAR--- 796 Query: 2522 LQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMES-------AVKLSVKLKV 2574 + Q+HDELL+EV + + + A +V+ MES ++L V LKV Sbjct: 797 ------------LVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKV 844 Query: 2575 KVKIGASWGEL 2585 + G SWG L Sbjct: 845 SLSAGRSWGHL 855 >gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD protein, partial [Homo sapiens] Length = 1700 Score = 136 bits (343), Expect = 2e-31 Identities = 136/435 (31%), Positives = 207/435 (47%), Gaps = 66/435 (15%) Query: 109 KNLVYSAPTSAGKTLVAELLILKRVLEMRK----------KALFILPFVSVAKEKKYYLQ 158 +NL+ APT AGKT VA + +L+ + + K ++I P S+ +E Sbjct: 61 ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG 120 Query: 159 SLFQEVGIKVDGYMGSTSPSRH-FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDE 217 GI V G + S+ I VCT E+ + + + E L+ ++V+DE Sbjct: 121 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDE 180 Query: 218 LHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASW 277 +H+L D RG +LE L+ + R Q D V+++G+SATLPN E VA++ Sbjct: 181 IHLLHDD-RGPVLEALVARAI---RNIEMTQED--------VRLIGLSATLPNYEDVATF 228 Query: 278 LNAE----LYHTD--FRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCY 331 L + L++ D FRPVPL E VG + K ++ F+ M ++ Y Sbjct: 229 LRVDPAKGLFYFDNSFRPVPL-EQTYVGIT----EKKAIKRFQIMNEI----------VY 273 Query: 332 ETICDN---HSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELL 388 E I ++ + VL+F S+K K A I L + S V+ + E Sbjct: 274 EKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQC 333 Query: 389 EVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSS 448 + ++ L+ +P+G A HHAG+T +R ++E F I+VL +T+TL+ Sbjct: 334 KNLE------------LKDLLPYGFAIHHAGMTRVDRTLVEDLFGDKHIQVLVSTATLAW 381 Query: 449 GVNLPARRVIIR-TPIFG---GR--PLDILTYKQMVGRAGRKGVDTVGESILICKNSEKS 502 GVNLPA VII+ T ++ GR L L QM+GRAGR DT GE ILI + E Sbjct: 382 GVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQ 441 Query: 503 KGIALLQGSLKPVRS 517 ++LL L P+ S Sbjct: 442 YYLSLLNQQL-PIES 455 Score = 115 bits (288), Expect = 6e-25 Identities = 130/498 (26%), Positives = 226/498 (45%), Gaps = 79/498 (15%) Query: 110 NLVYSAPTSAGKTLVAELLILKRVLEMRK-KALFILPFVSVAKEKKY--YLQSLFQEVGI 166 N+ APT +GKT+ AE IL+ +L+ + + ++I P + + +E+ Y + + + Sbjct: 909 NVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITP-MRLWQEQVYMDWYEKFQDRLNK 967 Query: 167 KVDGYMGSTSPS-RHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSH 225 KV G TS + +I + T E+ + L R + + + + VVDE+H++G + Sbjct: 968 KVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGEN 1027 Query: 226 RGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAEL--- 282 G +LE++ +++ YI+ S + ++IV +S++L N + VA WL Sbjct: 1028 -GPVLEVICSRMRYIS-----------SQIERPIRIVALSSSLSNAKDVAHWLGCSATST 1075 Query: 283 --YHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHS- 339 +H + RPVPL ++ G +I + +L+ +P+ H ++ HS Sbjct: 1076 FNFHPNVRPVPLELHIQ-GFNISHTQTRLLSMAKPVF-------HAIT--------KHSP 1119 Query: 340 ---VLLFCPSKKWCEKLA-DIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLR 395 V++F PS+K A DI+ ++ Q + C +K+L+ +++L Sbjct: 1120 KKPVIVFVPSRKQTRLTAIDILTTCAADIQRQ-----RFLHCT-----EKDLIPYLEKLS 1169 Query: 396 RLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPAR 455 DS L++T+ GV + H GL+ ER ++E F G I+V+ A+ +L G+N+ A Sbjct: 1170 ------DSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAH 1223 Query: 456 RVIIR-TPIFGGRPLDILTYK-----QMVGRAGRKGVDTVGESILICKNSEKSKGIALLQ 509 VII T + G+ + Y QMVG A R D G +++C+ S+K L Sbjct: 1224 LVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLY 1283 Query: 510 GSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGK-- 567 L PV S L + ++ +E QD Y TFL M + Sbjct: 1284 EPL-PVESHLDHCMHDHFNAEIVTKTIE--------NKQDAVDYLTWTFLYRRMTQNPNY 1334 Query: 568 ---QGIQRNQESVQLGAI 582 QGI S L + Sbjct: 1335 YNLQGISHRHLSDHLSEL 1352 >gi|40217847 activating signal cointegrator 1 complex subunit 3-like 1 [Homo sapiens] Length = 2136 Score = 136 bits (343), Expect = 2e-31 Identities = 135/435 (31%), Positives = 207/435 (47%), Gaps = 66/435 (15%) Query: 109 KNLVYSAPTSAGKTLVAELLILKRVLEMRK----------KALFILPFVSVAKEKKYYLQ 158 +NL+ APT AGKT VA + +L+ + + K ++I P S+ +E Sbjct: 497 ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG 556 Query: 159 SLFQEVGIKVDGYMGSTSPSRH-FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDE 217 GI V G + S+ I VCT E+ + + + E L+ ++++DE Sbjct: 557 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDE 616 Query: 218 LHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASW 277 +H+L D RG +LE L+ + R Q D V+++G+SATLPN E VA++ Sbjct: 617 IHLLHDD-RGPVLEALVARAI---RNIEMTQED--------VRLIGLSATLPNYEDVATF 664 Query: 278 LNAE----LYHTD--FRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCY 331 L + L++ D FRPVPL E VG + K ++ F+ M ++ Y Sbjct: 665 LRVDPAKGLFYFDNSFRPVPL-EQTYVGIT----EKKAIKRFQIMNEI----------VY 709 Query: 332 ETICDN---HSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELL 388 E I ++ + VL+F S+K K A I L + S V+ + E Sbjct: 710 EKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQC 769 Query: 389 EVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSS 448 + ++ L+ +P+G A HHAG+T +R ++E F I+VL +T+TL+ Sbjct: 770 KNLE------------LKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAW 817 Query: 449 GVNLPARRVIIR-TPIFG---GR--PLDILTYKQMVGRAGRKGVDTVGESILICKNSEKS 502 GVNLPA VII+ T ++ GR L L QM+GRAGR DT GE ILI + E Sbjct: 818 GVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQ 877 Query: 503 KGIALLQGSLKPVRS 517 ++LL L P+ S Sbjct: 878 YYLSLLNQQL-PIES 891 Score = 120 bits (300), Expect = 2e-26 Identities = 131/497 (26%), Positives = 226/497 (45%), Gaps = 77/497 (15%) Query: 110 NLVYSAPTSAGKTLVAELLILKRVLEMRK-KALFILPFVSVAKEKKYYLQSLFQE-VGIK 167 N+ APT +GKT+ AE IL+ +L+ + + ++I P ++A++ FQ+ + K Sbjct: 1345 NVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKK 1404 Query: 168 VDGYMGSTSPS-RHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHR 226 V G TS + +I + T E+ + L R + + + + VVDE+H++G + Sbjct: 1405 VVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGEN- 1463 Query: 227 GYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAEL---- 282 G +LE++ +++ YI+ S + ++IV +S++L N + VA WL Sbjct: 1464 GPVLEVICSRMRYIS-----------SQIERPIRIVALSSSLSNAKDVAHWLGCSATSTF 1512 Query: 283 -YHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHS-- 339 +H + RPVPL ++ G +I + +L+ +P+ H ++ HS Sbjct: 1513 NFHPNVRPVPLELHIQ-GFNISHTQTRLLSMAKPVY-------HAIT--------KHSPK 1556 Query: 340 --VLLFCPSKKWCEKLA-DIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRR 396 V++F PS+K A DI+ ++ Q + C +K+L+ +++L Sbjct: 1557 KPVIVFVPSRKQTRLTAIDILTTCAADIQRQ-----RFLHCT-----EKDLIPYLEKLS- 1605 Query: 397 LPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARR 456 DS L++T+ GV + H GL+ ER ++E F G I+V+ A+ +L G+N+ A Sbjct: 1606 -----DSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHL 1660 Query: 457 VIIR-TPIFGGRPLDILTYK-----QMVGRAGRKGVDTVGESILICKNSEKSKGIALLQG 510 VII T + G+ + Y QMVG A R D G +++C+ S+K L Sbjct: 1661 VIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYE 1720 Query: 511 SLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGK--- 567 L PV S L + ++ +E QD Y TFL M + Sbjct: 1721 PL-PVESHLDHCMHDHFNAEIVTKTIE--------NKQDAVDYLTWTFLYRRMTQNPNYY 1771 Query: 568 --QGIQRNQESVQLGAI 582 QGI S L + Sbjct: 1772 NLQGISHRHLSDHLSEL 1788 >gi|130484567 HFM1 protein [Homo sapiens] Length = 1435 Score = 135 bits (340), Expect = 5e-31 Identities = 120/445 (26%), Positives = 215/445 (48%), Gaps = 57/445 (12%) Query: 109 KNLVYSAPTSAGKTLVAELLILKRVLE-----MRKKALFILPFVSVAKEKKYYLQSLFQE 163 +N V APT +GKT+V EL I + ++E + K +++ P ++ ++ + F Sbjct: 297 RNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGP 356 Query: 164 VGIKVDGYMGSTSPSRHFS--SLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHML 221 +G+ G T F I + T E+ + + + + + + L+ + ++DE+H++ Sbjct: 357 IGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIV 416 Query: 222 GDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLN-- 279 D +RG LE++++++ + S + + +S + ++ V +SAT+PN E +A WL+ Sbjct: 417 KDENRGPTLEVVVSRMKTVQSVSQTLKN---TSTAIPMRFVAVSATIPNAEDIAEWLSDG 473 Query: 280 ---AELYHTD--FRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETI 334 A D RPV L KV SS + +F+ L K ++ + Sbjct: 474 ERPAVCLKMDESHRPVKLQ---KVVLGFPCSSNQTEFKFDLTLNYK------IASVIQMY 524 Query: 335 CDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQL 394 D L+FC ++K ++ A ++ ++ + + +EQK+ L+ Sbjct: 525 SDQKPTLVFCATRKGVQQAASVLVKDAKFI---------------MTVEQKQRLQ----- 564 Query: 395 RRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPA 454 + S DS L+ + G A+HHAG+ +R ++EGAF G + VL TSTL+ GVNLPA Sbjct: 565 KYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPA 624 Query: 455 RRVIIRTPIF--GG-----RPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIAL 507 V+I++ + GG DIL QM+GRAGR DT ++++ + S + K I + Sbjct: 625 HLVVIKSTMHYAGGLFEEYSETDIL---QMIGRAGRPQFDTTATAVIMTRLSTRDKYIQM 681 Query: 508 LQGSLKPVRSCLQRREGEEVTGSMI 532 L V S L R E + ++ Sbjct: 682 L-ACRDTVESSLHRHLIEHLNAEIV 705 >gi|76880486 activating signal cointegrator 1 complex subunit 3 isoform a [Homo sapiens] Length = 2202 Score = 120 bits (302), Expect = 1e-26 Identities = 123/466 (26%), Positives = 213/466 (45%), Gaps = 68/466 (14%) Query: 110 NLVYSAPTSAGKTLVAELLILKRVLEM-RKKALFILPFVSVAKEKKYYLQSLFQE-VGIK 167 N++ APT +GKT+ AEL I + + KA++I P ++ +E+ + +E +G K Sbjct: 1344 NVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKK 1403 Query: 168 VDGYMGSTSPS-RHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHR 226 V G +P + + D+ V T E+ +G+ N + + ++++DE+H+LG+ R Sbjct: 1404 VIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGE-ER 1462 Query: 227 GYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAEL---- 282 G +LE+++++ +I +S V+IVG+S L N +A WLN + Sbjct: 1463 GPVLEVIVSRTNFI-----------SSHTEKPVRIVGLSTALANARDLADWLNIKQMGLF 1511 Query: 283 -YHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVL 341 + RPVPL ++ G ++ +P Q + VL Sbjct: 1512 NFRPSVRPVPLEVHIQ-GFPGQHYCPRMASMNKPAFQ-----------AIRSHSPAKPVL 1559 Query: 342 LFCPSKKWCEKLA-DIIAREFYNLHHQAEGLVKPSECPP--VILEQKELLEVMDQLRRLP 398 +F S++ A ++IA + E P + ++++E+ ++ +R Sbjct: 1560 IFVSSRRQTRLTALELIA------------FLATEEDPKQWLNMDEREMENIIATVR--- 1604 Query: 399 SGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVI 458 DS L+ T+ +G+ HHAGL +R +E F ++VL ATSTL+ GVN PA VI Sbjct: 1605 ---DSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVI 1661 Query: 459 IR-TPIFGGR-----PLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSL 512 I+ T + G+ I QM+GRAGR D G+++++ + +K L Sbjct: 1662 IKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPF 1721 Query: 513 KPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTF 558 PV S L G + + I GG ++ QD Y T+ Sbjct: 1722 -PVESSL--------LGVLSDHLNAEIAGGTITSKQDALDYITWTY 1758 Score = 120 bits (300), Expect = 2e-26 Identities = 118/431 (27%), Positives = 203/431 (47%), Gaps = 74/431 (17%) Query: 109 KNLVYSAPTSAGKTLVAELLILKRVLE------MRK---KALFILPFVSVAKEKKYYLQS 159 +N++ APT AGKT +A L +L + + ++K K +++ P ++A E Y Sbjct: 493 ENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSR 552 Query: 160 LFQEVGIKVDGYMGSTSPSR-HFSSLDIAVCTIERANGLINRLIEENKMD-LLGMVVVDE 217 + +GI V G S+ + V T E+ + + + + + + ++ ++++DE Sbjct: 553 RLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDE 612 Query: 218 LHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASW 277 +H+L + RG +LE ++ + R+ S Q+ ++I+G+SATLPN VA++ Sbjct: 613 VHLLHED-RGPVLESIVARTL---RQVESTQS--------MIRILGLSATLPNYLDVATF 660 Query: 278 LNAELY------HTDFRPVPLLES---VKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVS 328 L+ Y FRPVPL ++ +K N +Q + D V Sbjct: 661 LHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANK---------------MQQLNNMDEV-- 703 Query: 329 LCYETICDN----HSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQ 384 CYE + H V++F ++ + A + N H P++ +L + Sbjct: 704 -CYENVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNCGHIP--FFFPTQGHDYVLAE 760 Query: 385 KELLEVMD-QLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAAT 443 K++ + Q+R L P G + HHAG+ ++R+++E F G I+VL T Sbjct: 761 KQVQRSRNKQVREL-----------FPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCT 809 Query: 444 STLSSGVNLPARRVIIR-TPIFGGR-----PLDILTYKQMVGRAGRKGVDTVGESILICK 497 +TL+ GVNLPA VII+ T I+ + L IL Q+ GRAGR D GE I+I Sbjct: 810 ATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITT 869 Query: 498 NSEKSKGIALL 508 + + S + LL Sbjct: 870 HDKLSHYLTLL 880 >gi|193211480 superkiller viralicidic activity 2-like 2 [Homo sapiens] Length = 1042 Score = 107 bits (266), Expect = 2e-22 Identities = 121/458 (26%), Positives = 204/458 (44%), Gaps = 100/458 (21%) Query: 109 KNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKV 168 ++++ SA TSAGKT+ AE I + E +++ +F P +++ +K + FQ+VG+ Sbjct: 155 QSVLVSAHTSAGKTVCAEYAIALALRE-KQRVIFTSPIKALSNQKYREMYEEFQDVGLMT 213 Query: 169 DGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGY 228 G + + S L V T E ++ R E M + V+ DE+H + DS RG Sbjct: 214 ----GDVTINPTASCL---VMTTEILRSMLYRGSEV--MREVAWVIFDEIHYMRDSERGV 264 Query: 229 LLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWL------NAEL 282 + E + L + V V +SAT+PN A W+ + Sbjct: 265 VWE------------------ETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHV 306 Query: 283 YHTDFRPVPLL----------------ESVKVGNSIYDSSMKLVREFEPMLQVKGDED-- 324 +TD+RP PL E+ ++++M+++R+ + KGD+ Sbjct: 307 IYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDL--AKGDQKGR 364 Query: 325 -----------HVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVK 373 +V + E + V++F SKK CE A + + +N Sbjct: 365 KGGTKGPSNVFKIVKMIMER--NFQPVIIFSFSKKDCEAYALQMTKLDFNTD-------- 414 Query: 374 PSECPPVILEQKELLE---------VMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEE 424 E+K+++E + D+ ++LP ++ VL + G+ HH GL Sbjct: 415 ---------EEKKMVEEVFSNAIDCLSDEDKKLPQ-VEHVLP-LLKRGIGIHHGGLLPIL 463 Query: 425 RDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVII-RTPIFGGRPLDILT---YKQMVGR 480 ++ IE F +GLI+ L AT T + G+N+PAR V+ F G+ ++ Y QM GR Sbjct: 464 KETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGR 523 Query: 481 AGRKGVDTVGESIL-ICKNSEKSKGIALLQGSLKPVRS 517 AGR+G+D G IL + + + G LL+GS P+ S Sbjct: 524 AGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNS 561 >gi|67782311 superkiller viralicidic activity 2-like homolog [Homo sapiens] Length = 1246 Score = 89.7 bits (221), Expect = 3e-17 Identities = 123/502 (24%), Positives = 208/502 (41%), Gaps = 96/502 (19%) Query: 49 LKAAAAGECKPTVPDYERDKLLLANWGLP---KAVLEKYHSFGVKKMFEWQAECLLLGQV 105 LK A+ P P+ + W +P + + ++ + F+W E + + Sbjct: 262 LKEASTAVSTPEAPEPPSQE----QWAIPVDATSPVGDFYRLIPQPAFQWAFEPDVFQKQ 317 Query: 106 ----LEGKNLVY-SAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSL 160 LE + V+ +A TSAGKT+VAE I M + ++ P +++ +K ++ Sbjct: 318 AILHLERHDSVFVAAHTSAGKTVVAEYAIALAQKHMTR-TIYTSPIKALSNQKFRDFRNT 376 Query: 161 FQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHM 220 F +VG+ S + +I + + +I L V+ DE+H Sbjct: 377 FGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDL---------EWVIFDEVHY 427 Query: 221 LGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNA 280 + D RG + E +L L + V I+ +SAT+PN A W+ Sbjct: 428 INDVERGVVWEEVLIM------------------LPDHVSIILLSATVPNALEFADWIGR 469 Query: 281 ----ELY--HTDFRPVPLLESVKVGNSI--------------------YDSSMKLVREF- 313 ++Y T RPVPL + GNS Y ++++ +E Sbjct: 470 LKRRQIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERM 529 Query: 314 ----------EPMLQVKGDEDHVVSLCYETICDNHS---VLLFCPSKKWCEKLADIIARE 360 +P Q +D V L + V++F S+ C++ A + Sbjct: 530 SKHAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLT-- 587 Query: 361 FYNLHHQAEGLVKPSECPPV-ILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAG 419 + L SE + + Q+ L + R+LP L + + + G+ HH+G Sbjct: 588 -------SLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLH--MSELLNRGLGVHHSG 638 Query: 420 LTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRT--PIFGGRPLDIL--TYK 475 + ++I+E F +GL++VL AT T + GVN+PAR V+ + G D+L Y Sbjct: 639 ILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYV 698 Query: 476 QMVGRAGRKGVDTVGESILICK 497 QM GRAGR+G+D G IL+CK Sbjct: 699 QMAGRAGRRGLDPTGTVILLCK 720 >gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sapiens] Length = 1712 Score = 75.9 bits (185), Expect = 5e-13 Identities = 34/81 (41%), Positives = 57/81 (70%), Gaps = 5/81 (6%) Query: 412 GVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVII-RTPIFGGRPLD 470 G+ +HH+ ++F+E+ ++E FR+G +RV+ AT TL+ GVN+P + V+ + ++ LD Sbjct: 1260 GIGYHHSAMSFKEKQLVEILFRKGYLRVVTATGTLALGVNMPCKSVVFAQNSVY----LD 1315 Query: 471 ILTYKQMVGRAGRKGVDTVGE 491 L Y+QM GRAGR+G D +G+ Sbjct: 1316 ALNYRQMSGRAGRRGQDLMGD 1336 >gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Homo sapiens] Length = 1706 Score = 70.9 bits (172), Expect = 2e-11 Identities = 33/80 (41%), Positives = 55/80 (68%), Gaps = 5/80 (6%) Query: 412 GVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVII-RTPIFGGRPLD 470 G+ +HH+ + F+E++ +E F +GLIRV+ AT TL+ G+++P + V+ + ++ LD Sbjct: 1244 GIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGIHMPCKSVVFAQDSVY----LD 1299 Query: 471 ILTYKQMVGRAGRKGVDTVG 490 L Y+QM GRAGR+G D +G Sbjct: 1300 ALNYRQMSGRAGRRGQDLLG 1319 Score = 33.5 bits (75), Expect = 2.8 Identities = 59/269 (21%), Positives = 108/269 (40%), Gaps = 58/269 (21%) Query: 95 WQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKK 154 WQ E LL V + ++ V APTS+GKT A +++VL R+ + ++ +V+ AK Sbjct: 747 WQQE--LLDVVDKNESAVIVAPTSSGKT-YASYYCMEKVL--RESDVGVVVYVAPAK--- 798 Query: 155 YYLQSLFQEVGIKVDGYMGSTSPS-------------RHFSSLDIAVCTIERANGLINRL 201 SL +V V+ T P+ + + + + E L+ Sbjct: 799 ----SLVGQVAATVENRFTKTLPAGRTLCGAFTRDYCHNVLNCQVLITVPECFEILLLAP 854 Query: 202 IEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQI 261 + ++ + V+ DE+H LG ELLL I Sbjct: 855 HRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVII--------------------RCPF 894 Query: 262 VGMSATLPNLELVASWLNAELYH-------TDFRPVPLLESVKVGNSIYDSSMKLVREFE 314 + +SAT+ N L+ WL + + + + + ++ K N + D S K + +E Sbjct: 895 LVLSATINNPNLLTKWLQSVKQYWKQADKIMEEKCISEKQADKCLNFLQDHSYK-NQSYE 953 Query: 315 PMLQVKGD-----EDHVVSLCYETICDNH 338 L + G+ E H+ S+ ++ + +H Sbjct: 954 VRLVLYGERYNDLEKHICSVKHDDVYFDH 982 >gi|14251212 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 [Homo sapiens] Length = 824 Score = 49.3 bits (116), Expect = 5e-05 Identities = 96/434 (22%), Positives = 174/434 (40%), Gaps = 92/434 (21%) Query: 76 LPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKR-VL 134 L + VLE + G ++ Q + + LG+ G +L+ A + GKT V + L VL Sbjct: 69 LSRPVLEGLRAAGFERPSPVQLKAIPLGRC--GLDLIVQAKSGTGKTCVFSTIALDSLVL 126 Query: 135 EMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDG-----YMGSTSPSRHFSSLDIAVC 189 E + IL + +E + S+ +GIK++G ++G T S+ + L Sbjct: 127 ENLSTQILIL---APTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKKCHI 183 Query: 190 TIERANGLINRLIEENKMD--LLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASC 247 + + G I +LIE + ++ + + ++DE L + G E + Sbjct: 184 AVG-SPGRIKQLIELDYLNPGSIRLFILDEADKLLEE--GSFQEQINW------------ 228 Query: 248 QADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSM 307 + SSL + Q++ +SAT P E +A+ L + F + + +G Y Sbjct: 229 ---IYSSLPASKQMLAVSATYP--EFLANALTKYMRDPTFVRLNSSDPSLIGLKQY---Y 280 Query: 308 KLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQ 367 K+V + +V ++ + + I N + L+F + LADI++ + + Sbjct: 281 KVVNSYPLAHKVFEEKTQHLQELFSRIPFNQA-LVFSNLHSRAQHLADILSSKGF----- 334 Query: 368 AEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDI 427 P+EC + Q + L+ M +L+ FH Sbjct: 335 ------PAECISGNMNQNQRLDAMAKLKH------------------FH----------- 359 Query: 428 IEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVD 487 RVL +T S G++ +++ + PLD TY +GRAGR G Sbjct: 360 ---------CRVLISTDLTSRGIDAEKVNLVVNLDV----PLDWETYMHRIGRAGRFG-- 404 Query: 488 TVGESILICKNSEK 501 T+G ++ C E+ Sbjct: 405 TLGLTVTYCCRGEE 418 >gi|116812616 RecQ protein-like 4 [Homo sapiens] Length = 1208 Score = 48.9 bits (115), Expect = 6e-05 Identities = 27/70 (38%), Positives = 38/70 (54%), Gaps = 4/70 (5%) Query: 416 HHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYK 475 +HAG+ ER ++ AF QG +RV+ AT G++ P R ++ G P +Y Sbjct: 744 YHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHL----GLPPSFESYV 799 Query: 476 QMVGRAGRKG 485 Q VGRAGR G Sbjct: 800 QAVGRAGRDG 809 >gi|4503529 eukaryotic translation initiation factor 4A isoform 1 [Homo sapiens] Length = 406 Score = 47.4 bits (111), Expect = 2e-04 Identities = 92/459 (20%), Positives = 183/459 (39%), Gaps = 114/459 (24%) Query: 49 LKAAAAGECKPTVPD-YERDKLLLANWG----------LPKAVLEKYHSFGVKKMFEWQA 97 + A+ + PD E + ++ +NW L +++L +++G +K Q Sbjct: 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ 60 Query: 98 ECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRV-LEMRK-KALFILPFVSVAKEKKY 155 +L ++G +++ A + GKT + IL+++ L+++ +AL + P +A++ + Sbjct: 61 RAIL--PCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQK 118 Query: 156 YLQSLFQEVGIKVDGYMGSTSPSRHFSSLD-----IAVCTIERANGLINRLIEENKMDLL 210 + +L +G +G T+ L I V T R ++NR K + Sbjct: 119 VVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKY--I 176 Query: 211 GMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPN 270 M V+DE + RG+ ++ D+ L++ Q+V +SAT+P+ Sbjct: 177 KMFVLDEADEM--LSRGFKDQIY----------------DIFQKLNSNTQVVLLSATMPS 218 Query: 271 --LELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVS 328 LE+ ++ P+ +L + + +++ +R+F + V+ +E + + Sbjct: 219 DVLEVTKKFMRD--------PIRILVKKE------ELTLEGIRQF--YINVEREEWKLDT 262 Query: 329 LC--YETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKE 386 LC YET+ +V+ F N + + L E Sbjct: 263 LCDLYETLTITQAVI-------------------FINTRRKVDWLT-------------E 290 Query: 387 LLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTL 446 + D + V+ H + +ERD+I FR G RVL T L Sbjct: 291 KMHARD------------------FTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLL 332 Query: 447 SSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKG 485 + G+++ ++I + P + Y +GR GR G Sbjct: 333 ARGIDVQQVSLVINYDL----PTNRENYIHRIGRGGRFG 367 >gi|83700235 eukaryotic translation initiation factor 4A2 [Homo sapiens] Length = 407 Score = 46.2 bits (108), Expect = 4e-04 Identities = 87/441 (19%), Positives = 174/441 (39%), Gaps = 115/441 (26%) Query: 67 DKLLLANWG----------LPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAP 116 D ++ +NW L +++L +++G +K Q ++ ++G +++ A Sbjct: 21 DGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAII--PCIKGYDVIAQAQ 78 Query: 117 TSAGKTLVAELLILKRV-LEMRK-KALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGS 174 + GKT + IL+++ +E ++ +AL + P +A++ + + +L +G +G Sbjct: 79 SGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGG 138 Query: 175 TSPSRHFSSLD-----IAVCTIERANGLINRLIEENKMDLLGMVVVDEL-HMLGDSHRGY 228 T+ L I V T R ++NR K + M V+DE ML + Sbjct: 139 TNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKW--IKMFVLDEADEMLSRGFKDQ 196 Query: 229 LLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPN--LELVASWLNAELYHTD 286 + E+ L+ ++Q+V +SAT+P LE+ ++ Sbjct: 197 IYEIF-------------------QKLNTSIQVVLLSATMPTDVLEVTKKFMRD------ 231 Query: 287 FRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLC--YETICDNHSVLLFC 344 P+ +L + + +++ +++F + V+ +E + +LC YET+ +V+ Sbjct: 232 --PIRILVKKE------ELTLEGIKQF--YINVEREEWKLDTLCDLYETLTITQAVI--- 278 Query: 345 PSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSV 404 F N + + L E + D Sbjct: 279 ----------------FLNTRRKVDWLT-------------EKMHARD------------ 297 Query: 405 LQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIF 464 + V+ H + +ERD+I FR G RVL T L+ G+++ ++I + Sbjct: 298 ------FTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDL- 350 Query: 465 GGRPLDILTYKQMVGRAGRKG 485 P + Y +GR GR G Sbjct: 351 ---PTNRENYIHRIGRGGRFG 368 >gi|110735439 Werner syndrome protein [Homo sapiens] Length = 1432 Score = 44.7 bits (104), Expect = 0.001 Identities = 26/73 (35%), Positives = 39/73 (53%), Gaps = 4/73 (5%) Query: 416 HHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYK 475 +HAG++F R I F + I+ + AT G+N + IR I G P D+ +Y Sbjct: 794 YHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGIN----KADIRQVIHYGAPKDMESYY 849 Query: 476 QMVGRAGRKGVDT 488 Q +GRAGR G+ + Sbjct: 850 QEIGRAGRDGLQS 862 >gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent helicase, partial [Homo sapiens] Length = 1140 Score = 44.7 bits (104), Expect = 0.001 Identities = 26/73 (35%), Positives = 39/73 (53%), Gaps = 4/73 (5%) Query: 416 HHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYK 475 +HAG++F R I F + I+ + AT G+N + IR I G P D+ +Y Sbjct: 502 YHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGIN----KADIRQVIHYGAPKDMESYY 557 Query: 476 QMVGRAGRKGVDT 488 Q +GRAGR G+ + Sbjct: 558 QEIGRAGRDGLQS 570 >gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I [Homo sapiens] Length = 925 Score = 43.1 bits (100), Expect = 0.004 Identities = 34/130 (26%), Positives = 62/130 (47%), Gaps = 13/130 (10%) Query: 106 LEGKNLVYSAPTSAGKTLVAELLI---LKRVLEMRK-KALFILPFVSVAKEKKYYLQSLF 161 ++GKN + APT GKT V+ L+ LK+ + +K K +F + V +++K F Sbjct: 255 MKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYF 314 Query: 162 QEVGIKVDGYMGSTSPSRHFSSL----DIAVCTIERANGLINRLIEEN--KMDLLGMVVV 215 + G +V G G+T+ + + DI + T + L+N L + + + +++ Sbjct: 315 ERHGYRVTGISGATAENVPVEQIVENNDIIILTPQI---LVNNLKKGTIPSLSIFTLMIF 371 Query: 216 DELHMLGDSH 225 DE H H Sbjct: 372 DECHNTSKQH 381 >gi|7661920 eukaryotic translation initiation factor 4A, isoform 3 [Homo sapiens] Length = 411 Score = 43.1 bits (100), Expect = 0.004 Identities = 84/434 (19%), Positives = 171/434 (39%), Gaps = 100/434 (23%) Query: 75 GLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRV- 133 GL + +L +++G +K Q + Q+++G++++ + + GKT + +L+ + Sbjct: 44 GLREDLLRGIYAYGFEKPSAIQQRAIK--QIIKGRDVIAQSQSGTGKTATFSISVLQCLD 101 Query: 134 LEMRK-KALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIE 192 +++R+ +AL + P +A + + L +L + ++ +G T+ LD + Sbjct: 102 IQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVA 161 Query: 193 RANGLINRLIEENKMDL--LGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQAD 250 G + +I + + M+V+DE + ++G+ ++ D Sbjct: 162 GTPGRVFDMIRRRSLRTRAIKMLVLDEADEM--LNKGFKEQIY----------------D 203 Query: 251 LASSLSNAVQIVGMSATLPN--LELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMK 308 + L A Q+V +SATLP+ LE+ ++ + R LE +K Sbjct: 204 VYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIK----------- 252 Query: 309 LVREFEPMLQVKGDEDHVVSLC--YETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHH 366 + + V+ +E +LC Y+T+ +V +FC +K+ + L + + + + Sbjct: 253 -----QFFVAVEREEWKFDTLCDLYDTLTITQAV-IFCNTKRKVDWLTEKMREANFTVSS 306 Query: 367 QAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERD 426 + QKE +M + Sbjct: 307 MHGD-----------MPQKERESIMKE--------------------------------- 322 Query: 427 IIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGV 486 FR G RVL +T + G+++P +II + R L Y +GR+GR G Sbjct: 323 -----FRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL----YIHRIGRSGRYG- 372 Query: 487 DTVGESILICKNSE 500 G +I KN + Sbjct: 373 -RKGVAINFVKNDD 385 >gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo sapiens] Length = 483 Score = 41.2 bits (95), Expect = 0.013 Identities = 87/423 (20%), Positives = 165/423 (39%), Gaps = 94/423 (22%) Query: 106 LEGKNLVYSAPTSAGKTLVAELLILKRVLEMRK---KALFILPFVSVAKEKKYYLQSLFQ 162 L G++++ A GK+ + +L+R L+++K +A+ I+P +A + + + Sbjct: 131 LSGRDILARAKNGTGKSGAYLIPLLER-LDLKKDNIQAMVIVPTRELALQVSQICIQVSK 189 Query: 163 EVG-IKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEEN--KMDLLGMVVVDELH 219 +G KV G T+ LD V + G I LI++ K+D + M+V+DE Sbjct: 190 HMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEAD 249 Query: 220 MLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLN 279 L +++ D+ +L QI+ SAT P V ++N Sbjct: 250 KL------------------LSQDFVQIMEDIILTLPKNRQILLYSATFPLS--VQKFMN 289 Query: 280 AELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHS 339 + L +P + N + + ++K V ++ + + + H ++ + + N S Sbjct: 290 SHLQ----KPYEI-------NLMEELTLKGVTQYYAYVTER-QKVHCLNTLFSRLQINQS 337 Query: 340 VLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPS 399 ++ FC S + E LA I++ Y+ Sbjct: 338 II-FCNSSQRVELLAKKISQLGYSCF---------------------------------- 362 Query: 400 GLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVII 459 + HA + E R+ + FR GL R L T + G+++ A V+I Sbjct: 363 ---------------YIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVI 407 Query: 460 RTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGS-LKPVRSC 518 P TY +GR+GR G + +++ + K I G+ +KP+ S Sbjct: 408 NFDF----PKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSN 463 Query: 519 LQR 521 + + Sbjct: 464 IDK 466 >gi|13129006 nucleolar protein GU2 [Homo sapiens] Length = 737 Score = 41.2 bits (95), Expect = 0.013 Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 8/88 (9%) Query: 417 HAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQ 476 H + +R+I FR+G +VL AT+ + G+++P ++I++ P D+ +Y Sbjct: 419 HGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQS----SPPQDVESYIH 474 Query: 477 MVGRAGRKGVDTVGESILICKNSEKSKG 504 GR GR G I IC + +G Sbjct: 475 RSGRTGRAG----RTGICICFYQPRERG 498 Score = 36.6 bits (83), Expect = 0.33 Identities = 35/169 (20%), Positives = 75/169 (44%), Gaps = 14/169 (8%) Query: 65 ERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLV 124 E+ + +N+ + + ++ GV +F Q + G V EGK+L+ A T GKT Sbjct: 133 EQKEGAFSNFPISEETIKLLKGRGVTYLFPIQVKTF--GPVYEGKDLIAQARTGTGKTFS 190 Query: 125 AELLILKRVLEMRK--------KALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTS 176 + +++R+ ++ K L + P +A + + + +++ + + G TS Sbjct: 191 FAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLSVAC--FYGGTS 248 Query: 177 PSRHFSSLDIAVCTIERANGLINRLIEENKMDL--LGMVVVDELHMLGD 223 + + + + G I ++ ++DL L VV+DE+ + D Sbjct: 249 YQSQINHIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLD 297 >gi|21071032 DEAD-box protein abstrakt [Homo sapiens] Length = 622 Score = 41.2 bits (95), Expect = 0.013 Identities = 26/69 (37%), Positives = 34/69 (49%), Gaps = 4/69 (5%) Query: 417 HAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQ 476 H G EER AFR+G VL AT S G++ PA + +I + P +I Y Sbjct: 463 HGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDM----PEEIENYVH 518 Query: 477 MVGRAGRKG 485 +GR GR G Sbjct: 519 RIGRTGRSG 527 >gi|34740327 zinc finger protein 804A [Homo sapiens] Length = 1209 Score = 39.7 bits (91), Expect = 0.039 Identities = 65/373 (17%), Positives = 136/373 (36%), Gaps = 56/373 (15%) Query: 903 LLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKS 962 + S+T ++ + +E+ + + + K I S+ K + + +D + Sbjct: 136 MFKSTTVTVRENCNEISQRVVVDSVNNQ-----QDFKYTLIHSEENTKDATTVAEDPESA 190 Query: 963 REHTSSFNC--NFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS 1020 +T+ N + G H+ F K+AS+ + S+ + D V + FS Sbjct: 191 NNYTAKNNQVGDQAQGIHRHKIGFSFAFPKKASVKLESSAAAFSEY---SDDASVGKGFS 247 Query: 1021 QKTKKAP------------LNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQ 1068 +K++ P + +SE+ + SF + K + + +K+ + + Sbjct: 248 RKSRFVPSACHLQQSSPTDVLLSSEEKTNSFHPPEAMCRDKETVQTQEIKE-----VSSE 302 Query: 1069 GQTLSNPSLCEDPFTLDEKKTEFRNSGPFAKNVSLSG---KEKDNKTSFPLQIKQNCSWN 1125 L PS C+ L +NS P A + L E + ++ N S Sbjct: 303 KDALLLPSFCKFQLQLSSDADNCQNSVPLADQIPLESVVINEDIPVSGNSFELLGNKSTV 362 Query: 1126 ITLTNDNFVEHIVTGSQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMK 1185 + ++ND T K+ T V ++ G E L + ++ N+ Sbjct: 363 LDMSNDCISVQATTEENVKHNEASTTEVENKNG----------PETLAPSNTEEVNI--- 409 Query: 1186 HHDIHPINQYLRKQSHEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCE------- 1238 IH + ++Q + K ++ + Q P E + Y +++ +C Sbjct: 410 --TIHKKTNFCKRQCEPFVPVLNKHRSTV-LQWPSEML-VYTTTKPSISYSCNPLCFDFK 465 Query: 1239 --RIKLNTEENKP 1249 ++ N ++NKP Sbjct: 466 STKVNNNLDKNKP 478 >gi|149408122 RNA helicase LGP2 [Homo sapiens] Length = 678 Score = 39.3 bits (90), Expect = 0.051 Identities = 39/141 (27%), Positives = 60/141 (42%), Gaps = 22/141 (15%) Query: 91 KMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVA 150 + ++W+ ++ LEGKN++ PT AGKT A + KR LE A V V Sbjct: 4 RSYQWE----VIMPALEGKNIIIWLPTGAGKTRAA-AYVAKRHLETVDGAK-----VVVL 53 Query: 151 KEKKYYLQSLFQEVGIKVDG------YMGSTSPSRHFSSL----DIAVCTIERANGLINR 200 + + + +E +DG G P F L D+ +CT E + Sbjct: 54 VNRVHLVTQHGEEFRRMLDGRWTVTTLSGDMGPRAGFGHLARCHDLLICTAELLQMALTS 113 Query: 201 LIEENKMDL--LGMVVVDELH 219 EE ++L ++VVDE H Sbjct: 114 PEEEEHVELTVFSLIVVDECH 134 >gi|27886568 interferon induced with helicase C domain 1 [Homo sapiens] Length = 1025 Score = 39.3 bits (90), Expect = 0.051 Identities = 36/129 (27%), Positives = 62/129 (48%), Gaps = 17/129 (13%) Query: 106 LEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKA-----------LFILPFVSVAKEKK 154 LEGKN++ PT +GKT VA + I K L+ +KKA +L KE + Sbjct: 320 LEGKNIIICLPTGSGKTRVA-VYIAKDHLDKKKKASEPGKVIVLVNKVLLVEQLFRKEFQ 378 Query: 155 YYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIE-RANGLINRLIEEN---KMDLL 210 +L+ ++ +G+ D + + P S DI + T + N L+N E+ ++ Sbjct: 379 PFLKKWYRVIGLSGDTQLKISFP-EVVKSCDIIISTAQILENSLLNLENGEDAGVQLSDF 437 Query: 211 GMVVVDELH 219 ++++DE H Sbjct: 438 SLIIIDECH 446 >gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens] Length = 938 Score = 38.9 bits (89), Expect = 0.067 Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 4/83 (4%) Query: 417 HAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQ 476 H + ER+ + F++ I VL AT + G+++P+ + +I + DI T+ Sbjct: 529 HGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDV----ARDIDTHTH 584 Query: 477 MVGRAGRKGVDTVGESILICKNS 499 +GR GR G V ++L K+S Sbjct: 585 RIGRTGRAGEKGVAYTLLTPKDS 607 >gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens] Length = 938 Score = 38.9 bits (89), Expect = 0.067 Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 4/83 (4%) Query: 417 HAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQ 476 H + ER+ + F++ I VL AT + G+++P+ + +I + DI T+ Sbjct: 529 HGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDV----ARDIDTHTH 584 Query: 477 MVGRAGRKGVDTVGESILICKNS 499 +GR GR G V ++L K+S Sbjct: 585 RIGRTGRAGEKGVAYTLLTPKDS 607 >gi|74048554 cancer susceptibility candidate 5 isoform 2 [Homo sapiens] Length = 2316 Score = 38.5 bits (88), Expect = 0.087 Identities = 68/359 (18%), Positives = 138/359 (38%), Gaps = 41/359 (11%) Query: 956 VQDLNKSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKV 1015 VQ+ N R +S +F + + QT S + +++ + E+ +N +KK+ Sbjct: 44 VQESNALRNKKNSRRVSFADTIKVFQTESHMKIVRKSEM----EETETGENLLLIQNKKL 99 Query: 1016 VQTFSQKTKKAPL---NFNSEKMSRSFRSWKRRKHLKRSRDSSPL-KDSGACRIHLQGQT 1071 + + T L +++ + F + + K + D + + D + Sbjct: 100 EDNYCEITGMNTLLSAPIHTQMQQKEFSIIEHTRERKHANDQTVIFSDENQMDLTSSHTV 159 Query: 1072 LSNPSLCEDPFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTND 1131 + L ++P + EK T+ + F N+ L ++ K + QN S + + Sbjct: 160 MITKGLLDNP--ISEKSTKIDTTS-FLANLKLHTEDSRMKKEVNFSVDQNTSSENKIDFN 216 Query: 1132 NFVEHIVTGSQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHP 1191 +F++ + TG C A V +K I SK N H +H Sbjct: 217 DFIKRLKTGK------CSAFPDVPDK-----------ENFEIPIYSKEPNSASSTHQMH- 258 Query: 1192 INQYLRKQSHEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSH 1251 + + E S IT+ + R+ + + + T+ + N+ E+K + Sbjct: 259 ----VSLKEDENNSNITR----LFREKDDGMNFTQCHTANIQTLIPTSSETNSRESKGND 310 Query: 1252 FQALGDDISRTVIPS--EVLPSAGAFSKSEGQHENFLNISR--LQEKTGTYTTNKTKNN 1306 G+D ++LP+ G FS+ E Q +N ++++ + +G T K+K N Sbjct: 311 ITIYGNDFMDLTFNHTLQILPATGNFSEIENQTQNAMDVTTGYGTKASGNKTVFKSKQN 369 >gi|40068059 CBF1 interacting corepressor [Homo sapiens] Length = 450 Score = 38.1 bits (87), Expect = 0.11 Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 24/155 (15%) Query: 906 SSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREH 965 SS+ S + S +E E + S++ + KK+ K + S +S + +D +K R+ Sbjct: 261 SSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGH--NNSDSEEKDKSKKRKL 318 Query: 966 TSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFSQKT-- 1023 + + N R++A KEKP ++E D K + S K Sbjct: 319 HEELSSSHHN-------------REKA-----KEKPRFLKHESSREDSKWSHSDSDKKSR 360 Query: 1024 --KKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSP 1056 K +P SE+ S RS R + +RSR SP Sbjct: 361 THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSP 395 >gi|51339291 sterile alpha motif domain containing 9-like [Homo sapiens] Length = 1584 Score = 38.1 bits (87), Expect = 0.11 Identities = 30/120 (25%), Positives = 52/120 (43%), Gaps = 13/120 (10%) Query: 870 LTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSESEVKEHT--FISQT 927 L E L+++E + ++DLVEMG+ W P L+ S L E H + + Sbjct: 37 LLSEEVTGLVLQE---LTEKDLVEMGLPWGPALLIKRSYNKLNSKSPESDNHDPGQLDNS 93 Query: 928 KSS------YKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREHTSSFNCNFQNGNQEHQ 981 K S K T K + N++ S+ I + P ++D+ + N + N +H+ Sbjct: 94 KPSKTEHQKNPKHTKKEEENSMSSN--IDYDPREIRDIKQEESILMKENVLDEVANAKHK 151 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.132 0.379 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 94,803,041 Number of Sequences: 37866 Number of extensions: 4301921 Number of successful extensions: 12489 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 15 Number of HSP's successfully gapped in prelim test: 86 Number of HSP's that attempted gapping in prelim test: 12307 Number of HSP's gapped (non-prelim): 224 length of query: 2590 length of database: 18,247,518 effective HSP length: 119 effective length of query: 2471 effective length of database: 13,741,464 effective search space: 33955157544 effective search space used: 33955157544 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.