Guide to the Human Genome
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Search of human proteins with 139394648

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|139394648 DNA polymerase theta [Homo sapiens]
         (2590 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|139394648 DNA polymerase theta [Homo sapiens]                     5136   0.0  
gi|110556640 DNA helicase HEL308 [Homo sapiens]                       416   e-115
gi|112420958 DNA-directed DNA polymerase nu [Homo sapiens]            230   2e-59
gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD prote...   136   2e-31
gi|40217847 activating signal cointegrator 1 complex subunit 3-l...   136   2e-31
gi|130484567 HFM1 protein [Homo sapiens]                              135   5e-31
gi|76880486 activating signal cointegrator 1 complex subunit 3 i...   120   1e-26
gi|193211480 superkiller viralicidic activity 2-like 2 [Homo sap...   107   2e-22
gi|67782311 superkiller viralicidic activity 2-like homolog [Hom...    90   3e-17
gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sap...    76   5e-13
gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Hom...    71   2e-11
gi|14251212 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 [Homo sapi...    49   5e-05
gi|116812616 RecQ protein-like 4 [Homo sapiens]                        49   6e-05
gi|4503529 eukaryotic translation initiation factor 4A isoform 1...    47   2e-04
gi|83700235 eukaryotic translation initiation factor 4A2 [Homo s...    46   4e-04
gi|110735439 Werner syndrome protein [Homo sapiens]                    45   0.001
gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent...    45   0.001
gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I [...    43   0.004
gi|7661920 eukaryotic translation initiation factor 4A, isoform ...    43   0.004
gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo sapi...    41   0.013
gi|13129006 nucleolar protein GU2 [Homo sapiens]                       41   0.013
gi|21071032 DEAD-box protein abstrakt [Homo sapiens]                   41   0.013
gi|34740327 zinc finger protein 804A [Homo sapiens]                    40   0.039
gi|149408122 RNA helicase LGP2 [Homo sapiens]                          39   0.051
gi|27886568 interferon induced with helicase C domain 1 [Homo sa...    39   0.051
gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens]             39   0.067
gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens]             39   0.067
gi|74048554 cancer susceptibility candidate 5 isoform 2 [Homo sa...    39   0.087
gi|40068059 CBF1 interacting corepressor [Homo sapiens]                38   0.11 
gi|51339291 sterile alpha motif domain containing 9-like [Homo s...    38   0.11 

>gi|139394648 DNA polymerase theta [Homo sapiens]
          Length = 2590

 Score = 5136 bits (13322), Expect = 0.0
 Identities = 2590/2590 (100%), Positives = 2590/2590 (100%)

Query: 1    MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT 60
            MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
Sbjct: 1    MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT 60

Query: 61   VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG 120
            VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
Sbjct: 61   VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG 120

Query: 121  KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH 180
            KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
Sbjct: 121  KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH 180

Query: 181  FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI 240
            FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
Sbjct: 181  FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI 240

Query: 241  TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN 300
            TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
Sbjct: 241  TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN 300

Query: 301  SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE 360
            SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
Sbjct: 301  SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE 360

Query: 361  FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL 420
            FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
Sbjct: 361  FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL 420

Query: 421  TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR 480
            TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
Sbjct: 421  TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR 480

Query: 481  AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV 540
            AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
Sbjct: 481  AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV 540

Query: 541  GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA 600
            GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
Sbjct: 541  GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA 600

Query: 601  SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED 660
            SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
Sbjct: 601  SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED 660

Query: 661  WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF 720
            WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
Sbjct: 661  WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF 720

Query: 721  TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ 780
            TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
Sbjct: 721  TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ 780

Query: 781  FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK 840
            FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
Sbjct: 781  FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK 840

Query: 841  SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP 900
            SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
Sbjct: 841  SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP 900

Query: 901  CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN 960
            CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
Sbjct: 901  CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN 960

Query: 961  KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS 1020
            KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
Sbjct: 961  KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS 1020

Query: 1021 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED 1080
            QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
Sbjct: 1021 QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED 1080

Query: 1081 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG 1140
            PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
Sbjct: 1081 PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG 1140

Query: 1141 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS 1200
            SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
Sbjct: 1141 SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS 1200

Query: 1201 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS 1260
            HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
Sbjct: 1201 HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS 1260

Query: 1261 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED 1320
            RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
Sbjct: 1261 RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED 1320

Query: 1321 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH 1380
            SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
Sbjct: 1321 SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH 1380

Query: 1381 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS 1440
            PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
Sbjct: 1381 PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS 1440

Query: 1441 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV 1500
            QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
Sbjct: 1441 QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV 1500

Query: 1501 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE 1560
            KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
Sbjct: 1501 KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE 1560

Query: 1561 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL 1620
            MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
Sbjct: 1561 MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL 1620

Query: 1621 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE 1680
            TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
Sbjct: 1621 TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE 1680

Query: 1681 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI 1740
            VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
Sbjct: 1681 VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI 1740

Query: 1741 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS 1800
            PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
Sbjct: 1741 PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS 1800

Query: 1801 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR 1860
            DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
Sbjct: 1801 DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR 1860

Query: 1861 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE 1920
            SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
Sbjct: 1861 SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE 1920

Query: 1921 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI 1980
            QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
Sbjct: 1921 QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI 1980

Query: 1981 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH 2040
            SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
Sbjct: 1981 SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH 2040

Query: 2041 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE 2100
            SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
Sbjct: 2041 SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE 2100

Query: 2101 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS 2160
            SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
Sbjct: 2101 SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS 2160

Query: 2161 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL 2220
            TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
Sbjct: 2161 TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL 2220

Query: 2221 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM 2280
            NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
Sbjct: 2221 NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM 2280

Query: 2281 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA 2340
            GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
Sbjct: 2281 GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA 2340

Query: 2341 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE 2400
            HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
Sbjct: 2341 HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE 2400

Query: 2401 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR 2460
            QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
Sbjct: 2401 QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR 2460

Query: 2461 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKR 2520
            KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKR
Sbjct: 2461 KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKR 2520

Query: 2521 KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA 2580
            KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA
Sbjct: 2521 KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA 2580

Query: 2581 SWGELKDFDV 2590
            SWGELKDFDV
Sbjct: 2581 SWGELKDFDV 2590


>gi|110556640 DNA helicase HEL308 [Homo sapiens]
          Length = 1101

 Score =  416 bits (1070), Expect = e-115
 Identities = 277/806 (34%), Positives = 440/806 (54%), Gaps = 68/806 (8%)

Query: 74   WGLPKAVLEKYHSF-GVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKR 132
            + LP  V + Y  F G++K++EWQ  CL L  V E KNL+YS PTS GKTLVAE+L+L+ 
Sbjct: 317  YSLPSKVRDLYAQFKGIEKLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQE 376

Query: 133  VLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTS---PSRHFSSLDIAVC 189
            +L  RK  L ILP+V++ +EK   L S   E+G  V+ Y GS     P++      + + 
Sbjct: 377  LLCCRKDVLMILPYVAIVQEKISGLSSFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIA 436

Query: 190  TIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQA 249
            TIE+ + L+N LIE  ++D LG+VVVDELHM+G+  RG  LE+ L KI Y          
Sbjct: 437  TIEKGHSLVNSLIETGRIDSLGLVVVDELHMIGEGSRGATLEMTLAKILYT--------- 487

Query: 250  DLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIY--DSSM 307
                  S   QI+GMSATL N+E +  +L AE Y + FRPV L E +K+ ++IY  DS  
Sbjct: 488  ------SKTTQIIGMSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYEVDSKA 541

Query: 308  KLVREFEPMLQVKG-------DEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE 360
            +    F  +L  K        D DH+V+L  E I  N+S L+FCPSKK CE +A++I + 
Sbjct: 542  ENGMTFSRLLNYKYSDTLKKMDPDHLVALVTEVI-PNYSCLVFCPSKKNCENVAEMICK- 599

Query: 361  FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSG-LDSVLQKTVPWGVAFHHAG 419
            F +  +                ++KE  EV+  L+ + +G L  VL++T+P+GVA+HH+G
Sbjct: 600  FLSKEYLKH-------------KEKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAYHHSG 646

Query: 420  LTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVG 479
            LT +ER ++E A+  G++ +   TSTL++GVNLPARRVI+R P      L    YKQM+G
Sbjct: 647  LTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVAKEFLKRNQYKQMIG 706

Query: 480  RAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEII 539
            RAGR G+DT+GESILI +  +K + + L+    KP+ +C      +E T  +    L +I
Sbjct: 707  RAGRAGIDTIGESILILQEKDKQQVLELI---TKPLENCYSHLV-QEFTKGIQTLFLSLI 762

Query: 540  VGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTE 599
               +A+   D++ +   TF     K     +   ++S+    +E+ + +L E   +Q   
Sbjct: 763  GLKIATNLDDIYHFMNGTFFGVQQK-----VLLKEKSLWEITVES-LRYLTEKGLLQKDT 816

Query: 600  ASDGTEGKVY--HPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPM 657
                 E   Y  H T LG A+   ++  A    ++ DL++ ++G VLE+ LH++YL TP 
Sbjct: 817  IYKSEEEVQYNFHITKLGRASFKGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTTPY 876

Query: 658  -FEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIH 716
                    DW  +F  + +L  + + VA ++GV E F+ +   G+ + +   ++    + 
Sbjct: 877  DLVSQCNPDWMIYFRQFSQLSPAEQNVAAILGVSESFIGKKASGQAIGKKVDKN----VV 932

Query: 717  KRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRL-GWHNME 775
             R + S VL  L+ E  +  +++K+   RG IQ+L    A ++  +  F   L  +    
Sbjct: 933  NRLYLSFVLYTLLKETNIWTVSEKFNMPRGYIQNLLTGTASFSSCVLHFCEELEEFWVYR 992

Query: 776  LLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARAN----IVEVEV 831
             LL +  K+LT+ ++ EL  L+ V+ +   RA+ LY++G+ ++  LA AN    +  ++ 
Sbjct: 993  ALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTIDH 1052

Query: 832  ILKNAVP--FKSARKAVDEEEEAVEE 855
            + +        SA+  + E+ EA++E
Sbjct: 1053 LSRRQAKQIVSSAKMLLHEKAEALQE 1078


>gi|112420958 DNA-directed DNA polymerase nu [Homo sapiens]
          Length = 900

 Score =  230 bits (586), Expect = 2e-59
 Identities = 180/611 (29%), Positives = 289/611 (47%), Gaps = 116/611 (18%)

Query: 1988 DPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGL---NAGSEHSGRY 2044
            DP++A WL+DP    P+   +V  +   E  +   + ++ G  S  +   N        Y
Sbjct: 348  DPRIAAWLIDPSDATPSFEDLVEKYC--EKSITVKVNSTYGNSSRNIVNQNVRENLKTLY 405

Query: 2045 RASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKH 2104
            R +++          L S L+   L  +FR +E+P    LA++E + I  +  E E    
Sbjct: 406  RLTMD----------LCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSA 455

Query: 2105 IMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRG 2164
            ++ A+L  +E +A+ +AG  F  TS++ + E+LF +LKL              L S R  
Sbjct: 456  LLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKL-------------HLLSQRNS 502

Query: 2165 IDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFL 2224
            +    +  L +  STS+ VLN L+ LHPLP +ILE+R++    +  V  L    C+    
Sbjct: 503  LP---RTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLL--ACMKKG- 556

Query: 2225 GMERIYPVSQSHTATGRITFTEPNIQNVPR-DFEIKMPTLVGESPPSQAVGKGLLPMGRG 2283
             +   +  +Q+ T TGR++   PNIQ + +   +I  P                    +G
Sbjct: 557  SISSTW--NQTGTVTGRLSAKHPNIQGISKHPIQITTPKNF-----------------KG 597

Query: 2284 KYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILAHLS 2343
            K  K  +++PR                       FV   G + LAAD+SQ+ELRIL HLS
Sbjct: 598  KEDKILTISPRAM---------------------FVSSKGHTFLAADFSQIELRILTHLS 636

Query: 2344 HDRRLIQVLNTGA--DVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQ 2401
             D  L+++       DVF ++ ++WK +  E V    R+Q K++ Y ++YG G + L   
Sbjct: 637  GDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAAC 696

Query: 2402 MGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRK 2461
            +G+   +AA +++SF  +Y  I  F    +  C + G V +I+GRRR LP I  ++   +
Sbjct: 697  LGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLR 756

Query: 2462 AHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKRK 2521
            A AERQA+N +VQGSAAD+ K+A +++      F +   SH           T  +R   
Sbjct: 757  AQAERQAVNFVVQGSAADLCKLAMIHV------FTAVAASH-----------TLTAR--- 796

Query: 2522 LQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMES-------AVKLSVKLKV 2574
                         + Q+HDELL+EV +  + + A +V+  MES        ++L V LKV
Sbjct: 797  ------------LVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKV 844

Query: 2575 KVKIGASWGEL 2585
             +  G SWG L
Sbjct: 845  SLSAGRSWGHL 855


>gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD protein,
           partial [Homo sapiens]
          Length = 1700

 Score =  136 bits (343), Expect = 2e-31
 Identities = 136/435 (31%), Positives = 207/435 (47%), Gaps = 66/435 (15%)

Query: 109 KNLVYSAPTSAGKTLVAELLILKRVLEMRK----------KALFILPFVSVAKEKKYYLQ 158
           +NL+  APT AGKT VA + +L+ + +             K ++I P  S+ +E      
Sbjct: 61  ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG 120

Query: 159 SLFQEVGIKVDGYMGSTSPSRH-FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDE 217
                 GI V    G     +   S+  I VCT E+ + +  +  E     L+ ++V+DE
Sbjct: 121 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDE 180

Query: 218 LHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASW 277
           +H+L D  RG +LE L+ +     R     Q D        V+++G+SATLPN E VA++
Sbjct: 181 IHLLHDD-RGPVLEALVARAI---RNIEMTQED--------VRLIGLSATLPNYEDVATF 228

Query: 278 LNAE----LYHTD--FRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCY 331
           L  +    L++ D  FRPVPL E   VG +      K ++ F+ M ++           Y
Sbjct: 229 LRVDPAKGLFYFDNSFRPVPL-EQTYVGIT----EKKAIKRFQIMNEI----------VY 273

Query: 332 ETICDN---HSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELL 388
           E I ++   + VL+F  S+K   K A  I             L + S    V+  + E  
Sbjct: 274 EKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQC 333

Query: 389 EVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSS 448
           + ++            L+  +P+G A HHAG+T  +R ++E  F    I+VL +T+TL+ 
Sbjct: 334 KNLE------------LKDLLPYGFAIHHAGMTRVDRTLVEDLFGDKHIQVLVSTATLAW 381

Query: 449 GVNLPARRVIIR-TPIFG---GR--PLDILTYKQMVGRAGRKGVDTVGESILICKNSEKS 502
           GVNLPA  VII+ T ++    GR   L  L   QM+GRAGR   DT GE ILI  + E  
Sbjct: 382 GVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQ 441

Query: 503 KGIALLQGSLKPVRS 517
             ++LL   L P+ S
Sbjct: 442 YYLSLLNQQL-PIES 455



 Score =  115 bits (288), Expect = 6e-25
 Identities = 130/498 (26%), Positives = 226/498 (45%), Gaps = 79/498 (15%)

Query: 110  NLVYSAPTSAGKTLVAELLILKRVLEMRK-KALFILPFVSVAKEKKY--YLQSLFQEVGI 166
            N+   APT +GKT+ AE  IL+ +L+  + + ++I P + + +E+ Y  + +     +  
Sbjct: 909  NVFVGAPTGSGKTICAEFAILRMLLQNSEGRCVYITP-MRLWQEQVYMDWYEKFQDRLNK 967

Query: 167  KVDGYMGSTSPS-RHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSH 225
            KV    G TS   +     +I + T E+ + L  R  +   +  + + VVDE+H++G  +
Sbjct: 968  KVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGEN 1027

Query: 226  RGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAEL--- 282
             G +LE++ +++ YI+           S +   ++IV +S++L N + VA WL       
Sbjct: 1028 -GPVLEVICSRMRYIS-----------SQIERPIRIVALSSSLSNAKDVAHWLGCSATST 1075

Query: 283  --YHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHS- 339
              +H + RPVPL   ++ G +I  +  +L+   +P+        H ++         HS 
Sbjct: 1076 FNFHPNVRPVPLELHIQ-GFNISHTQTRLLSMAKPVF-------HAIT--------KHSP 1119

Query: 340  ---VLLFCPSKKWCEKLA-DIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLR 395
               V++F PS+K     A DI+     ++  Q     +   C      +K+L+  +++L 
Sbjct: 1120 KKPVIVFVPSRKQTRLTAIDILTTCAADIQRQ-----RFLHCT-----EKDLIPYLEKLS 1169

Query: 396  RLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPAR 455
                  DS L++T+  GV + H GL+  ER ++E  F  G I+V+ A+ +L  G+N+ A 
Sbjct: 1170 ------DSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAH 1223

Query: 456  RVIIR-TPIFGGRPLDILTYK-----QMVGRAGRKGVDTVGESILICKNSEKSKGIALLQ 509
             VII  T  + G+    + Y      QMVG A R   D  G  +++C+ S+K      L 
Sbjct: 1224 LVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLY 1283

Query: 510  GSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGK-- 567
              L PV S L     +     ++   +E          QD   Y   TFL   M +    
Sbjct: 1284 EPL-PVESHLDHCMHDHFNAEIVTKTIE--------NKQDAVDYLTWTFLYRRMTQNPNY 1334

Query: 568  ---QGIQRNQESVQLGAI 582
               QGI     S  L  +
Sbjct: 1335 YNLQGISHRHLSDHLSEL 1352


>gi|40217847 activating signal cointegrator 1 complex subunit 3-like
           1 [Homo sapiens]
          Length = 2136

 Score =  136 bits (343), Expect = 2e-31
 Identities = 135/435 (31%), Positives = 207/435 (47%), Gaps = 66/435 (15%)

Query: 109 KNLVYSAPTSAGKTLVAELLILKRVLEMRK----------KALFILPFVSVAKEKKYYLQ 158
           +NL+  APT AGKT VA + +L+ + +             K ++I P  S+ +E      
Sbjct: 497 ENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFG 556

Query: 159 SLFQEVGIKVDGYMGSTSPSRH-FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDE 217
                 GI V    G     +   S+  I VCT E+ + +  +  E     L+ ++++DE
Sbjct: 557 KRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDE 616

Query: 218 LHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASW 277
           +H+L D  RG +LE L+ +     R     Q D        V+++G+SATLPN E VA++
Sbjct: 617 IHLLHDD-RGPVLEALVARAI---RNIEMTQED--------VRLIGLSATLPNYEDVATF 664

Query: 278 LNAE----LYHTD--FRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCY 331
           L  +    L++ D  FRPVPL E   VG +      K ++ F+ M ++           Y
Sbjct: 665 LRVDPAKGLFYFDNSFRPVPL-EQTYVGIT----EKKAIKRFQIMNEI----------VY 709

Query: 332 ETICDN---HSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELL 388
           E I ++   + VL+F  S+K   K A  I             L + S    V+  + E  
Sbjct: 710 EKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQC 769

Query: 389 EVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSS 448
           + ++            L+  +P+G A HHAG+T  +R ++E  F    I+VL +T+TL+ 
Sbjct: 770 KNLE------------LKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAW 817

Query: 449 GVNLPARRVIIR-TPIFG---GR--PLDILTYKQMVGRAGRKGVDTVGESILICKNSEKS 502
           GVNLPA  VII+ T ++    GR   L  L   QM+GRAGR   DT GE ILI  + E  
Sbjct: 818 GVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQ 877

Query: 503 KGIALLQGSLKPVRS 517
             ++LL   L P+ S
Sbjct: 878 YYLSLLNQQL-PIES 891



 Score =  120 bits (300), Expect = 2e-26
 Identities = 131/497 (26%), Positives = 226/497 (45%), Gaps = 77/497 (15%)

Query: 110  NLVYSAPTSAGKTLVAELLILKRVLEMRK-KALFILPFVSVAKEKKYYLQSLFQE-VGIK 167
            N+   APT +GKT+ AE  IL+ +L+  + + ++I P  ++A++        FQ+ +  K
Sbjct: 1345 NVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKK 1404

Query: 168  VDGYMGSTSPS-RHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHR 226
            V    G TS   +     +I + T E+ + L  R  +   +  + + VVDE+H++G  + 
Sbjct: 1405 VVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGEN- 1463

Query: 227  GYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAEL---- 282
            G +LE++ +++ YI+           S +   ++IV +S++L N + VA WL        
Sbjct: 1464 GPVLEVICSRMRYIS-----------SQIERPIRIVALSSSLSNAKDVAHWLGCSATSTF 1512

Query: 283  -YHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHS-- 339
             +H + RPVPL   ++ G +I  +  +L+   +P+        H ++         HS  
Sbjct: 1513 NFHPNVRPVPLELHIQ-GFNISHTQTRLLSMAKPVY-------HAIT--------KHSPK 1556

Query: 340  --VLLFCPSKKWCEKLA-DIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRR 396
              V++F PS+K     A DI+     ++  Q     +   C      +K+L+  +++L  
Sbjct: 1557 KPVIVFVPSRKQTRLTAIDILTTCAADIQRQ-----RFLHCT-----EKDLIPYLEKLS- 1605

Query: 397  LPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARR 456
                 DS L++T+  GV + H GL+  ER ++E  F  G I+V+ A+ +L  G+N+ A  
Sbjct: 1606 -----DSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHL 1660

Query: 457  VIIR-TPIFGGRPLDILTYK-----QMVGRAGRKGVDTVGESILICKNSEKSKGIALLQG 510
            VII  T  + G+    + Y      QMVG A R   D  G  +++C+ S+K      L  
Sbjct: 1661 VIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYE 1720

Query: 511  SLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGK--- 567
             L PV S L     +     ++   +E          QD   Y   TFL   M +     
Sbjct: 1721 PL-PVESHLDHCMHDHFNAEIVTKTIE--------NKQDAVDYLTWTFLYRRMTQNPNYY 1771

Query: 568  --QGIQRNQESVQLGAI 582
              QGI     S  L  +
Sbjct: 1772 NLQGISHRHLSDHLSEL 1788


>gi|130484567 HFM1 protein [Homo sapiens]
          Length = 1435

 Score =  135 bits (340), Expect = 5e-31
 Identities = 120/445 (26%), Positives = 215/445 (48%), Gaps = 57/445 (12%)

Query: 109 KNLVYSAPTSAGKTLVAELLILKRVLE-----MRKKALFILPFVSVAKEKKYYLQSLFQE 163
           +N V  APT +GKT+V EL I + ++E     +  K +++ P  ++  ++    +  F  
Sbjct: 297 RNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGP 356

Query: 164 VGIKVDGYMGSTSPSRHFS--SLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHML 221
           +G+      G T     F      I + T E+ + +  +  + + + L+ + ++DE+H++
Sbjct: 357 IGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIV 416

Query: 222 GDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLN-- 279
            D +RG  LE++++++  +   S + +    +S +  ++ V +SAT+PN E +A WL+  
Sbjct: 417 KDENRGPTLEVVVSRMKTVQSVSQTLKN---TSTAIPMRFVAVSATIPNAEDIAEWLSDG 473

Query: 280 ---AELYHTD--FRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETI 334
              A     D   RPV L    KV      SS +   +F+  L  K      ++   +  
Sbjct: 474 ERPAVCLKMDESHRPVKLQ---KVVLGFPCSSNQTEFKFDLTLNYK------IASVIQMY 524

Query: 335 CDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQL 394
            D    L+FC ++K  ++ A ++ ++   +               + +EQK+ L+     
Sbjct: 525 SDQKPTLVFCATRKGVQQAASVLVKDAKFI---------------MTVEQKQRLQ----- 564

Query: 395 RRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPA 454
           +   S  DS L+  +  G A+HHAG+   +R ++EGAF  G + VL  TSTL+ GVNLPA
Sbjct: 565 KYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPA 624

Query: 455 RRVIIRTPIF--GG-----RPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIAL 507
             V+I++ +   GG        DIL   QM+GRAGR   DT   ++++ + S + K I +
Sbjct: 625 HLVVIKSTMHYAGGLFEEYSETDIL---QMIGRAGRPQFDTTATAVIMTRLSTRDKYIQM 681

Query: 508 LQGSLKPVRSCLQRREGEEVTGSMI 532
           L      V S L R   E +   ++
Sbjct: 682 L-ACRDTVESSLHRHLIEHLNAEIV 705


>gi|76880486 activating signal cointegrator 1 complex subunit 3
            isoform a [Homo sapiens]
          Length = 2202

 Score =  120 bits (302), Expect = 1e-26
 Identities = 123/466 (26%), Positives = 213/466 (45%), Gaps = 68/466 (14%)

Query: 110  NLVYSAPTSAGKTLVAELLILKRVLEM-RKKALFILPFVSVAKEKKYYLQSLFQE-VGIK 167
            N++  APT +GKT+ AEL I +   +    KA++I P  ++ +E+    +   +E +G K
Sbjct: 1344 NVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKK 1403

Query: 168  VDGYMGSTSPS-RHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHR 226
            V    G  +P  +  +  D+ V T E+ +G+       N +  + ++++DE+H+LG+  R
Sbjct: 1404 VIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGE-ER 1462

Query: 227  GYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAEL---- 282
            G +LE+++++  +I           +S     V+IVG+S  L N   +A WLN +     
Sbjct: 1463 GPVLEVIVSRTNFI-----------SSHTEKPVRIVGLSTALANARDLADWLNIKQMGLF 1511

Query: 283  -YHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVL 341
             +    RPVPL   ++ G        ++    +P  Q              +      VL
Sbjct: 1512 NFRPSVRPVPLEVHIQ-GFPGQHYCPRMASMNKPAFQ-----------AIRSHSPAKPVL 1559

Query: 342  LFCPSKKWCEKLA-DIIAREFYNLHHQAEGLVKPSECPP--VILEQKELLEVMDQLRRLP 398
            +F  S++     A ++IA             +   E P   + ++++E+  ++  +R   
Sbjct: 1560 IFVSSRRQTRLTALELIA------------FLATEEDPKQWLNMDEREMENIIATVR--- 1604

Query: 399  SGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVI 458
               DS L+ T+ +G+  HHAGL   +R  +E  F    ++VL ATSTL+ GVN PA  VI
Sbjct: 1605 ---DSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVI 1661

Query: 459  IR-TPIFGGR-----PLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSL 512
            I+ T  + G+        I    QM+GRAGR   D  G+++++  + +K      L    
Sbjct: 1662 IKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPF 1721

Query: 513  KPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTF 558
             PV S L         G +   +   I GG  ++ QD   Y   T+
Sbjct: 1722 -PVESSL--------LGVLSDHLNAEIAGGTITSKQDALDYITWTY 1758



 Score =  120 bits (300), Expect = 2e-26
 Identities = 118/431 (27%), Positives = 203/431 (47%), Gaps = 74/431 (17%)

Query: 109 KNLVYSAPTSAGKTLVAELLILKRVLE------MRK---KALFILPFVSVAKEKKYYLQS 159
           +N++  APT AGKT +A L +L  + +      ++K   K +++ P  ++A E   Y   
Sbjct: 493 ENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSR 552

Query: 160 LFQEVGIKVDGYMGSTSPSR-HFSSLDIAVCTIERANGLINRLIEENKMD-LLGMVVVDE 217
             + +GI V    G    S+       + V T E+ + +  + + +  +  ++ ++++DE
Sbjct: 553 RLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDE 612

Query: 218 LHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASW 277
           +H+L +  RG +LE ++ +     R+  S Q+         ++I+G+SATLPN   VA++
Sbjct: 613 VHLLHED-RGPVLESIVARTL---RQVESTQS--------MIRILGLSATLPNYLDVATF 660

Query: 278 LNAELY------HTDFRPVPLLES---VKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVS 328
           L+   Y         FRPVPL ++   +K  N                +Q   + D V  
Sbjct: 661 LHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANK---------------MQQLNNMDEV-- 703

Query: 329 LCYETICDN----HSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQ 384
            CYE +       H V++F  ++    + A  +     N  H       P++    +L +
Sbjct: 704 -CYENVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNCGHIP--FFFPTQGHDYVLAE 760

Query: 385 KELLEVMD-QLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAAT 443
           K++    + Q+R L            P G + HHAG+  ++R+++E  F  G I+VL  T
Sbjct: 761 KQVQRSRNKQVREL-----------FPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCT 809

Query: 444 STLSSGVNLPARRVIIR-TPIFGGR-----PLDILTYKQMVGRAGRKGVDTVGESILICK 497
           +TL+ GVNLPA  VII+ T I+  +      L IL   Q+ GRAGR   D  GE I+I  
Sbjct: 810 ATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITT 869

Query: 498 NSEKSKGIALL 508
           + + S  + LL
Sbjct: 870 HDKLSHYLTLL 880


>gi|193211480 superkiller viralicidic activity 2-like 2 [Homo
           sapiens]
          Length = 1042

 Score =  107 bits (266), Expect = 2e-22
 Identities = 121/458 (26%), Positives = 204/458 (44%), Gaps = 100/458 (21%)

Query: 109 KNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKV 168
           ++++ SA TSAGKT+ AE  I   + E +++ +F  P  +++ +K   +   FQ+VG+  
Sbjct: 155 QSVLVSAHTSAGKTVCAEYAIALALRE-KQRVIFTSPIKALSNQKYREMYEEFQDVGLMT 213

Query: 169 DGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGY 228
               G  + +   S L   V T E    ++ R  E   M  +  V+ DE+H + DS RG 
Sbjct: 214 ----GDVTINPTASCL---VMTTEILRSMLYRGSEV--MREVAWVIFDEIHYMRDSERGV 264

Query: 229 LLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWL------NAEL 282
           + E                  +    L + V  V +SAT+PN    A W+         +
Sbjct: 265 VWE------------------ETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHV 306

Query: 283 YHTDFRPVPLL----------------ESVKVGNSIYDSSMKLVREFEPMLQVKGDED-- 324
            +TD+RP PL                 E+       ++++M+++R+   +   KGD+   
Sbjct: 307 IYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDL--AKGDQKGR 364

Query: 325 -----------HVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVK 373
                       +V +  E   +   V++F  SKK CE  A  + +  +N          
Sbjct: 365 KGGTKGPSNVFKIVKMIMER--NFQPVIIFSFSKKDCEAYALQMTKLDFNTD-------- 414

Query: 374 PSECPPVILEQKELLE---------VMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEE 424
                    E+K+++E         + D+ ++LP  ++ VL   +  G+  HH GL    
Sbjct: 415 ---------EEKKMVEEVFSNAIDCLSDEDKKLPQ-VEHVLP-LLKRGIGIHHGGLLPIL 463

Query: 425 RDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVII-RTPIFGGRPLDILT---YKQMVGR 480
           ++ IE  F +GLI+ L AT T + G+N+PAR V+      F G+    ++   Y QM GR
Sbjct: 464 KETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGR 523

Query: 481 AGRKGVDTVGESIL-ICKNSEKSKGIALLQGSLKPVRS 517
           AGR+G+D  G  IL + +    + G  LL+GS  P+ S
Sbjct: 524 AGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNS 561


>gi|67782311 superkiller viralicidic activity 2-like homolog [Homo
           sapiens]
          Length = 1246

 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 123/502 (24%), Positives = 208/502 (41%), Gaps = 96/502 (19%)

Query: 49  LKAAAAGECKPTVPDYERDKLLLANWGLP---KAVLEKYHSFGVKKMFEWQAECLLLGQV 105
           LK A+     P  P+    +     W +P    + +  ++    +  F+W  E  +  + 
Sbjct: 262 LKEASTAVSTPEAPEPPSQE----QWAIPVDATSPVGDFYRLIPQPAFQWAFEPDVFQKQ 317

Query: 106 ----LEGKNLVY-SAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSL 160
               LE  + V+ +A TSAGKT+VAE  I      M +  ++  P  +++ +K    ++ 
Sbjct: 318 AILHLERHDSVFVAAHTSAGKTVVAEYAIALAQKHMTR-TIYTSPIKALSNQKFRDFRNT 376

Query: 161 FQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHM 220
           F +VG+           S    + +I    +   + +I  L           V+ DE+H 
Sbjct: 377 FGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDL---------EWVIFDEVHY 427

Query: 221 LGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNA 280
           + D  RG + E +L                    L + V I+ +SAT+PN    A W+  
Sbjct: 428 INDVERGVVWEEVLIM------------------LPDHVSIILLSATVPNALEFADWIGR 469

Query: 281 ----ELY--HTDFRPVPLLESVKVGNSI--------------------YDSSMKLVREF- 313
               ++Y   T  RPVPL   +  GNS                     Y ++++  +E  
Sbjct: 470 LKRRQIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERM 529

Query: 314 ----------EPMLQVKGDEDHVVSLCYETICDNHS---VLLFCPSKKWCEKLADIIARE 360
                     +P  Q    +D  V L         +   V++F  S+  C++ A  +   
Sbjct: 530 SKHAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLT-- 587

Query: 361 FYNLHHQAEGLVKPSECPPV-ILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAG 419
                  +  L   SE   + +  Q+ L  +    R+LP  L   + + +  G+  HH+G
Sbjct: 588 -------SLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLH--MSELLNRGLGVHHSG 638

Query: 420 LTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRT--PIFGGRPLDIL--TYK 475
           +    ++I+E  F +GL++VL AT T + GVN+PAR V+  +     G    D+L   Y 
Sbjct: 639 ILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYV 698

Query: 476 QMVGRAGRKGVDTVGESILICK 497
           QM GRAGR+G+D  G  IL+CK
Sbjct: 699 QMAGRAGRRGLDPTGTVILLCK 720


>gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sapiens]
          Length = 1712

 Score = 75.9 bits (185), Expect = 5e-13
 Identities = 34/81 (41%), Positives = 57/81 (70%), Gaps = 5/81 (6%)

Query: 412  GVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVII-RTPIFGGRPLD 470
            G+ +HH+ ++F+E+ ++E  FR+G +RV+ AT TL+ GVN+P + V+  +  ++    LD
Sbjct: 1260 GIGYHHSAMSFKEKQLVEILFRKGYLRVVTATGTLALGVNMPCKSVVFAQNSVY----LD 1315

Query: 471  ILTYKQMVGRAGRKGVDTVGE 491
             L Y+QM GRAGR+G D +G+
Sbjct: 1316 ALNYRQMSGRAGRRGQDLMGD 1336


>gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Homo
            sapiens]
          Length = 1706

 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 33/80 (41%), Positives = 55/80 (68%), Gaps = 5/80 (6%)

Query: 412  GVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVII-RTPIFGGRPLD 470
            G+ +HH+ + F+E++ +E  F +GLIRV+ AT TL+ G+++P + V+  +  ++    LD
Sbjct: 1244 GIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGIHMPCKSVVFAQDSVY----LD 1299

Query: 471  ILTYKQMVGRAGRKGVDTVG 490
             L Y+QM GRAGR+G D +G
Sbjct: 1300 ALNYRQMSGRAGRRGQDLLG 1319



 Score = 33.5 bits (75), Expect = 2.8
 Identities = 59/269 (21%), Positives = 108/269 (40%), Gaps = 58/269 (21%)

Query: 95  WQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKK 154
           WQ E  LL  V + ++ V  APTS+GKT  A    +++VL  R+  + ++ +V+ AK   
Sbjct: 747 WQQE--LLDVVDKNESAVIVAPTSSGKT-YASYYCMEKVL--RESDVGVVVYVAPAK--- 798

Query: 155 YYLQSLFQEVGIKVDGYMGSTSPS-------------RHFSSLDIAVCTIERANGLINRL 201
               SL  +V   V+     T P+              +  +  + +   E    L+   
Sbjct: 799 ----SLVGQVAATVENRFTKTLPAGRTLCGAFTRDYCHNVLNCQVLITVPECFEILLLAP 854

Query: 202 IEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQI 261
             +  ++ +  V+ DE+H LG        ELLL  I                        
Sbjct: 855 HRQKWVERIRYVIFDEVHYLGREVGAKFWELLLVII--------------------RCPF 894

Query: 262 VGMSATLPNLELVASWLNAELYH-------TDFRPVPLLESVKVGNSIYDSSMKLVREFE 314
           + +SAT+ N  L+  WL +   +        + + +   ++ K  N + D S K  + +E
Sbjct: 895 LVLSATINNPNLLTKWLQSVKQYWKQADKIMEEKCISEKQADKCLNFLQDHSYK-NQSYE 953

Query: 315 PMLQVKGD-----EDHVVSLCYETICDNH 338
             L + G+     E H+ S+ ++ +  +H
Sbjct: 954 VRLVLYGERYNDLEKHICSVKHDDVYFDH 982


>gi|14251212 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 [Homo
           sapiens]
          Length = 824

 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 96/434 (22%), Positives = 174/434 (40%), Gaps = 92/434 (21%)

Query: 76  LPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKR-VL 134
           L + VLE   + G ++    Q + + LG+   G +L+  A +  GKT V   + L   VL
Sbjct: 69  LSRPVLEGLRAAGFERPSPVQLKAIPLGRC--GLDLIVQAKSGTGKTCVFSTIALDSLVL 126

Query: 135 EMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDG-----YMGSTSPSRHFSSLDIAVC 189
           E     + IL   +  +E    + S+   +GIK++G     ++G T  S+  + L     
Sbjct: 127 ENLSTQILIL---APTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKKCHI 183

Query: 190 TIERANGLINRLIEENKMD--LLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASC 247
            +  + G I +LIE + ++   + + ++DE   L +   G   E +              
Sbjct: 184 AVG-SPGRIKQLIELDYLNPGSIRLFILDEADKLLEE--GSFQEQINW------------ 228

Query: 248 QADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSM 307
              + SSL  + Q++ +SAT P  E +A+ L   +    F  +   +   +G   Y    
Sbjct: 229 ---IYSSLPASKQMLAVSATYP--EFLANALTKYMRDPTFVRLNSSDPSLIGLKQY---Y 280

Query: 308 KLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQ 367
           K+V  +    +V  ++   +   +  I  N + L+F       + LADI++ + +     
Sbjct: 281 KVVNSYPLAHKVFEEKTQHLQELFSRIPFNQA-LVFSNLHSRAQHLADILSSKGF----- 334

Query: 368 AEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDI 427
                 P+EC    + Q + L+ M +L+                   FH           
Sbjct: 335 ------PAECISGNMNQNQRLDAMAKLKH------------------FH----------- 359

Query: 428 IEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVD 487
                     RVL +T   S G++     +++   +    PLD  TY   +GRAGR G  
Sbjct: 360 ---------CRVLISTDLTSRGIDAEKVNLVVNLDV----PLDWETYMHRIGRAGRFG-- 404

Query: 488 TVGESILICKNSEK 501
           T+G ++  C   E+
Sbjct: 405 TLGLTVTYCCRGEE 418


>gi|116812616 RecQ protein-like 4 [Homo sapiens]
          Length = 1208

 Score = 48.9 bits (115), Expect = 6e-05
 Identities = 27/70 (38%), Positives = 38/70 (54%), Gaps = 4/70 (5%)

Query: 416 HHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYK 475
           +HAG+   ER  ++ AF QG +RV+ AT     G++ P  R ++      G P    +Y 
Sbjct: 744 YHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHL----GLPPSFESYV 799

Query: 476 QMVGRAGRKG 485
           Q VGRAGR G
Sbjct: 800 QAVGRAGRDG 809


>gi|4503529 eukaryotic translation initiation factor 4A isoform 1
           [Homo sapiens]
          Length = 406

 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 92/459 (20%), Positives = 183/459 (39%), Gaps = 114/459 (24%)

Query: 49  LKAAAAGECKPTVPD-YERDKLLLANWG----------LPKAVLEKYHSFGVKKMFEWQA 97
           + A+     +   PD  E + ++ +NW           L +++L   +++G +K    Q 
Sbjct: 1   MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ 60

Query: 98  ECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRV-LEMRK-KALFILPFVSVAKEKKY 155
             +L    ++G +++  A +  GKT    + IL+++ L+++  +AL + P   +A++ + 
Sbjct: 61  RAIL--PCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQK 118

Query: 156 YLQSLFQEVGIKVDGYMGSTSPSRHFSSLD-----IAVCTIERANGLINRLIEENKMDLL 210
            + +L   +G      +G T+       L      I V T  R   ++NR     K   +
Sbjct: 119 VVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKY--I 176

Query: 211 GMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPN 270
            M V+DE   +    RG+  ++                 D+   L++  Q+V +SAT+P+
Sbjct: 177 KMFVLDEADEM--LSRGFKDQIY----------------DIFQKLNSNTQVVLLSATMPS 218

Query: 271 --LELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVS 328
             LE+   ++          P+ +L   +      + +++ +R+F   + V+ +E  + +
Sbjct: 219 DVLEVTKKFMRD--------PIRILVKKE------ELTLEGIRQF--YINVEREEWKLDT 262

Query: 329 LC--YETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKE 386
           LC  YET+    +V+                   F N   + + L              E
Sbjct: 263 LCDLYETLTITQAVI-------------------FINTRRKVDWLT-------------E 290

Query: 387 LLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTL 446
            +   D                  + V+  H  +  +ERD+I   FR G  RVL  T  L
Sbjct: 291 KMHARD------------------FTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLL 332

Query: 447 SSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKG 485
           + G+++    ++I   +    P +   Y   +GR GR G
Sbjct: 333 ARGIDVQQVSLVINYDL----PTNRENYIHRIGRGGRFG 367


>gi|83700235 eukaryotic translation initiation factor 4A2 [Homo
           sapiens]
          Length = 407

 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 87/441 (19%), Positives = 174/441 (39%), Gaps = 115/441 (26%)

Query: 67  DKLLLANWG----------LPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAP 116
           D ++ +NW           L +++L   +++G +K    Q   ++    ++G +++  A 
Sbjct: 21  DGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAII--PCIKGYDVIAQAQ 78

Query: 117 TSAGKTLVAELLILKRV-LEMRK-KALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGS 174
           +  GKT    + IL+++ +E ++ +AL + P   +A++ +  + +L   +G      +G 
Sbjct: 79  SGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGG 138

Query: 175 TSPSRHFSSLD-----IAVCTIERANGLINRLIEENKMDLLGMVVVDEL-HMLGDSHRGY 228
           T+       L      I V T  R   ++NR     K   + M V+DE   ML    +  
Sbjct: 139 TNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKW--IKMFVLDEADEMLSRGFKDQ 196

Query: 229 LLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPN--LELVASWLNAELYHTD 286
           + E+                      L+ ++Q+V +SAT+P   LE+   ++        
Sbjct: 197 IYEIF-------------------QKLNTSIQVVLLSATMPTDVLEVTKKFMRD------ 231

Query: 287 FRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLC--YETICDNHSVLLFC 344
             P+ +L   +      + +++ +++F   + V+ +E  + +LC  YET+    +V+   
Sbjct: 232 --PIRILVKKE------ELTLEGIKQF--YINVEREEWKLDTLCDLYETLTITQAVI--- 278

Query: 345 PSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSV 404
                           F N   + + L              E +   D            
Sbjct: 279 ----------------FLNTRRKVDWLT-------------EKMHARD------------ 297

Query: 405 LQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIF 464
                 + V+  H  +  +ERD+I   FR G  RVL  T  L+ G+++    ++I   + 
Sbjct: 298 ------FTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDL- 350

Query: 465 GGRPLDILTYKQMVGRAGRKG 485
              P +   Y   +GR GR G
Sbjct: 351 ---PTNRENYIHRIGRGGRFG 368


>gi|110735439 Werner syndrome protein [Homo sapiens]
          Length = 1432

 Score = 44.7 bits (104), Expect = 0.001
 Identities = 26/73 (35%), Positives = 39/73 (53%), Gaps = 4/73 (5%)

Query: 416 HHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYK 475
           +HAG++F  R  I   F +  I+ + AT     G+N    +  IR  I  G P D+ +Y 
Sbjct: 794 YHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGIN----KADIRQVIHYGAPKDMESYY 849

Query: 476 QMVGRAGRKGVDT 488
           Q +GRAGR G+ +
Sbjct: 850 QEIGRAGRDGLQS 862


>gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent
           helicase, partial [Homo sapiens]
          Length = 1140

 Score = 44.7 bits (104), Expect = 0.001
 Identities = 26/73 (35%), Positives = 39/73 (53%), Gaps = 4/73 (5%)

Query: 416 HHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYK 475
           +HAG++F  R  I   F +  I+ + AT     G+N    +  IR  I  G P D+ +Y 
Sbjct: 502 YHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGIN----KADIRQVIHYGAPKDMESYY 557

Query: 476 QMVGRAGRKGVDT 488
           Q +GRAGR G+ +
Sbjct: 558 QEIGRAGRDGLQS 570


>gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I
           [Homo sapiens]
          Length = 925

 Score = 43.1 bits (100), Expect = 0.004
 Identities = 34/130 (26%), Positives = 62/130 (47%), Gaps = 13/130 (10%)

Query: 106 LEGKNLVYSAPTSAGKTLVAELLI---LKRVLEMRK-KALFILPFVSVAKEKKYYLQSLF 161
           ++GKN +  APT  GKT V+ L+    LK+  + +K K +F    + V +++K      F
Sbjct: 255 MKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYF 314

Query: 162 QEVGIKVDGYMGSTSPSRHFSSL----DIAVCTIERANGLINRLIEEN--KMDLLGMVVV 215
           +  G +V G  G+T+ +     +    DI + T +    L+N L +     + +  +++ 
Sbjct: 315 ERHGYRVTGISGATAENVPVEQIVENNDIIILTPQI---LVNNLKKGTIPSLSIFTLMIF 371

Query: 216 DELHMLGDSH 225
           DE H     H
Sbjct: 372 DECHNTSKQH 381


>gi|7661920 eukaryotic translation initiation factor 4A, isoform 3
           [Homo sapiens]
          Length = 411

 Score = 43.1 bits (100), Expect = 0.004
 Identities = 84/434 (19%), Positives = 171/434 (39%), Gaps = 100/434 (23%)

Query: 75  GLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRV- 133
           GL + +L   +++G +K    Q   +   Q+++G++++  + +  GKT    + +L+ + 
Sbjct: 44  GLREDLLRGIYAYGFEKPSAIQQRAIK--QIIKGRDVIAQSQSGTGKTATFSISVLQCLD 101

Query: 134 LEMRK-KALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIE 192
           +++R+ +AL + P   +A + +  L +L   + ++    +G T+       LD     + 
Sbjct: 102 IQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVA 161

Query: 193 RANGLINRLIEENKMDL--LGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQAD 250
              G +  +I    +    + M+V+DE   +   ++G+  ++                 D
Sbjct: 162 GTPGRVFDMIRRRSLRTRAIKMLVLDEADEM--LNKGFKEQIY----------------D 203

Query: 251 LASSLSNAVQIVGMSATLPN--LELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMK 308
           +   L  A Q+V +SATLP+  LE+   ++   +     R    LE +K           
Sbjct: 204 VYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIK----------- 252

Query: 309 LVREFEPMLQVKGDEDHVVSLC--YETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHH 366
                +  + V+ +E    +LC  Y+T+    +V +FC +K+  + L + +    + +  
Sbjct: 253 -----QFFVAVEREEWKFDTLCDLYDTLTITQAV-IFCNTKRKVDWLTEKMREANFTVSS 306

Query: 367 QAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERD 426
                          + QKE   +M +                                 
Sbjct: 307 MHGD-----------MPQKERESIMKE--------------------------------- 322

Query: 427 IIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGV 486
                FR G  RVL +T   + G+++P   +II   +   R L    Y   +GR+GR G 
Sbjct: 323 -----FRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL----YIHRIGRSGRYG- 372

Query: 487 DTVGESILICKNSE 500
              G +I   KN +
Sbjct: 373 -RKGVAINFVKNDD 385


>gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo
           sapiens]
          Length = 483

 Score = 41.2 bits (95), Expect = 0.013
 Identities = 87/423 (20%), Positives = 165/423 (39%), Gaps = 94/423 (22%)

Query: 106 LEGKNLVYSAPTSAGKTLVAELLILKRVLEMRK---KALFILPFVSVAKEKKYYLQSLFQ 162
           L G++++  A    GK+    + +L+R L+++K   +A+ I+P   +A +       + +
Sbjct: 131 LSGRDILARAKNGTGKSGAYLIPLLER-LDLKKDNIQAMVIVPTRELALQVSQICIQVSK 189

Query: 163 EVG-IKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEEN--KMDLLGMVVVDELH 219
            +G  KV    G T+       LD  V  +    G I  LI++   K+D + M+V+DE  
Sbjct: 190 HMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEAD 249

Query: 220 MLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLN 279
            L                  +++       D+  +L    QI+  SAT P    V  ++N
Sbjct: 250 KL------------------LSQDFVQIMEDIILTLPKNRQILLYSATFPLS--VQKFMN 289

Query: 280 AELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHS 339
           + L     +P  +       N + + ++K V ++   +  +  + H ++  +  +  N S
Sbjct: 290 SHLQ----KPYEI-------NLMEELTLKGVTQYYAYVTER-QKVHCLNTLFSRLQINQS 337

Query: 340 VLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPS 399
           ++ FC S +  E LA  I++  Y+                                    
Sbjct: 338 II-FCNSSQRVELLAKKISQLGYSCF---------------------------------- 362

Query: 400 GLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVII 459
                          + HA +  E R+ +   FR GL R L  T   + G+++ A  V+I
Sbjct: 363 ---------------YIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVI 407

Query: 460 RTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGS-LKPVRSC 518
                   P    TY   +GR+GR G   +  +++   +    K I    G+ +KP+ S 
Sbjct: 408 NFDF----PKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSN 463

Query: 519 LQR 521
           + +
Sbjct: 464 IDK 466


>gi|13129006 nucleolar protein GU2 [Homo sapiens]
          Length = 737

 Score = 41.2 bits (95), Expect = 0.013
 Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 8/88 (9%)

Query: 417 HAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQ 476
           H  +   +R+I    FR+G  +VL AT+  + G+++P   ++I++      P D+ +Y  
Sbjct: 419 HGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQS----SPPQDVESYIH 474

Query: 477 MVGRAGRKGVDTVGESILICKNSEKSKG 504
             GR GR G       I IC    + +G
Sbjct: 475 RSGRTGRAG----RTGICICFYQPRERG 498



 Score = 36.6 bits (83), Expect = 0.33
 Identities = 35/169 (20%), Positives = 75/169 (44%), Gaps = 14/169 (8%)

Query: 65  ERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLV 124
           E+ +   +N+ + +  ++     GV  +F  Q +    G V EGK+L+  A T  GKT  
Sbjct: 133 EQKEGAFSNFPISEETIKLLKGRGVTYLFPIQVKTF--GPVYEGKDLIAQARTGTGKTFS 190

Query: 125 AELLILKRVLEMRK--------KALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTS 176
             + +++R+   ++        K L + P   +A +     + + +++ +    + G TS
Sbjct: 191 FAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLSVAC--FYGGTS 248

Query: 177 PSRHFSSLDIAVCTIERANGLINRLIEENKMDL--LGMVVVDELHMLGD 223
                + +   +  +    G I   ++  ++DL  L  VV+DE+  + D
Sbjct: 249 YQSQINHIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLD 297


>gi|21071032 DEAD-box protein abstrakt [Homo sapiens]
          Length = 622

 Score = 41.2 bits (95), Expect = 0.013
 Identities = 26/69 (37%), Positives = 34/69 (49%), Gaps = 4/69 (5%)

Query: 417 HAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQ 476
           H G   EER     AFR+G   VL AT   S G++ PA + +I   +    P +I  Y  
Sbjct: 463 HGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDM----PEEIENYVH 518

Query: 477 MVGRAGRKG 485
            +GR GR G
Sbjct: 519 RIGRTGRSG 527


>gi|34740327 zinc finger protein 804A [Homo sapiens]
          Length = 1209

 Score = 39.7 bits (91), Expect = 0.039
 Identities = 65/373 (17%), Positives = 136/373 (36%), Gaps = 56/373 (15%)

Query: 903  LLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKS 962
            +  S+T ++  + +E+ +   +    +         K   I S+   K +  + +D   +
Sbjct: 136  MFKSTTVTVRENCNEISQRVVVDSVNNQ-----QDFKYTLIHSEENTKDATTVAEDPESA 190

Query: 963  REHTSSFNC--NFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS 1020
              +T+  N   +   G   H+    F   K+AS+ +       S+    + D  V + FS
Sbjct: 191  NNYTAKNNQVGDQAQGIHRHKIGFSFAFPKKASVKLESSAAAFSEY---SDDASVGKGFS 247

Query: 1021 QKTKKAP------------LNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQ 1068
            +K++  P            +  +SE+ + SF   +     K +  +  +K+     +  +
Sbjct: 248  RKSRFVPSACHLQQSSPTDVLLSSEEKTNSFHPPEAMCRDKETVQTQEIKE-----VSSE 302

Query: 1069 GQTLSNPSLCEDPFTLDEKKTEFRNSGPFAKNVSLSG---KEKDNKTSFPLQIKQNCSWN 1125
               L  PS C+    L       +NS P A  + L      E    +    ++  N S  
Sbjct: 303  KDALLLPSFCKFQLQLSSDADNCQNSVPLADQIPLESVVINEDIPVSGNSFELLGNKSTV 362

Query: 1126 ITLTNDNFVEHIVTGSQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMK 1185
            + ++ND       T    K+     T V ++ G           E L  + ++  N+   
Sbjct: 363  LDMSNDCISVQATTEENVKHNEASTTEVENKNG----------PETLAPSNTEEVNI--- 409

Query: 1186 HHDIHPINQYLRKQSHEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCE------- 1238
               IH    + ++Q       + K ++ +  Q P E +  Y     +++ +C        
Sbjct: 410  --TIHKKTNFCKRQCEPFVPVLNKHRSTV-LQWPSEML-VYTTTKPSISYSCNPLCFDFK 465

Query: 1239 --RIKLNTEENKP 1249
              ++  N ++NKP
Sbjct: 466  STKVNNNLDKNKP 478


>gi|149408122 RNA helicase LGP2 [Homo sapiens]
          Length = 678

 Score = 39.3 bits (90), Expect = 0.051
 Identities = 39/141 (27%), Positives = 60/141 (42%), Gaps = 22/141 (15%)

Query: 91  KMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVA 150
           + ++W+    ++   LEGKN++   PT AGKT  A   + KR LE    A      V V 
Sbjct: 4   RSYQWE----VIMPALEGKNIIIWLPTGAGKTRAA-AYVAKRHLETVDGAK-----VVVL 53

Query: 151 KEKKYYLQSLFQEVGIKVDG------YMGSTSPSRHFSSL----DIAVCTIERANGLINR 200
             + + +    +E    +DG        G   P   F  L    D+ +CT E     +  
Sbjct: 54  VNRVHLVTQHGEEFRRMLDGRWTVTTLSGDMGPRAGFGHLARCHDLLICTAELLQMALTS 113

Query: 201 LIEENKMDL--LGMVVVDELH 219
             EE  ++L    ++VVDE H
Sbjct: 114 PEEEEHVELTVFSLIVVDECH 134


>gi|27886568 interferon induced with helicase C domain 1 [Homo
           sapiens]
          Length = 1025

 Score = 39.3 bits (90), Expect = 0.051
 Identities = 36/129 (27%), Positives = 62/129 (48%), Gaps = 17/129 (13%)

Query: 106 LEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKA-----------LFILPFVSVAKEKK 154
           LEGKN++   PT +GKT VA + I K  L+ +KKA             +L      KE +
Sbjct: 320 LEGKNIIICLPTGSGKTRVA-VYIAKDHLDKKKKASEPGKVIVLVNKVLLVEQLFRKEFQ 378

Query: 155 YYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIE-RANGLINRLIEEN---KMDLL 210
            +L+  ++ +G+  D  +  + P     S DI + T +   N L+N    E+   ++   
Sbjct: 379 PFLKKWYRVIGLSGDTQLKISFP-EVVKSCDIIISTAQILENSLLNLENGEDAGVQLSDF 437

Query: 211 GMVVVDELH 219
            ++++DE H
Sbjct: 438 SLIIIDECH 446


>gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens]
          Length = 938

 Score = 38.9 bits (89), Expect = 0.067
 Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 4/83 (4%)

Query: 417 HAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQ 476
           H  +   ER+ +   F++  I VL AT   + G+++P+ + +I   +      DI T+  
Sbjct: 529 HGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDV----ARDIDTHTH 584

Query: 477 MVGRAGRKGVDTVGESILICKNS 499
            +GR GR G   V  ++L  K+S
Sbjct: 585 RIGRTGRAGEKGVAYTLLTPKDS 607


>gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens]
          Length = 938

 Score = 38.9 bits (89), Expect = 0.067
 Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 4/83 (4%)

Query: 417 HAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQ 476
           H  +   ER+ +   F++  I VL AT   + G+++P+ + +I   +      DI T+  
Sbjct: 529 HGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDV----ARDIDTHTH 584

Query: 477 MVGRAGRKGVDTVGESILICKNS 499
            +GR GR G   V  ++L  K+S
Sbjct: 585 RIGRTGRAGEKGVAYTLLTPKDS 607


>gi|74048554 cancer susceptibility candidate 5 isoform 2 [Homo
            sapiens]
          Length = 2316

 Score = 38.5 bits (88), Expect = 0.087
 Identities = 68/359 (18%), Positives = 138/359 (38%), Gaps = 41/359 (11%)

Query: 956  VQDLNKSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKV 1015
            VQ+ N  R   +S   +F +  +  QT S  +  +++ +    E+    +N     +KK+
Sbjct: 44   VQESNALRNKKNSRRVSFADTIKVFQTESHMKIVRKSEM----EETETGENLLLIQNKKL 99

Query: 1016 VQTFSQKTKKAPL---NFNSEKMSRSFRSWKRRKHLKRSRDSSPL-KDSGACRIHLQGQT 1071
               + + T    L     +++   + F   +  +  K + D + +  D     +      
Sbjct: 100  EDNYCEITGMNTLLSAPIHTQMQQKEFSIIEHTRERKHANDQTVIFSDENQMDLTSSHTV 159

Query: 1072 LSNPSLCEDPFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTND 1131
            +    L ++P  + EK T+   +  F  N+ L  ++   K      + QN S    +  +
Sbjct: 160  MITKGLLDNP--ISEKSTKIDTTS-FLANLKLHTEDSRMKKEVNFSVDQNTSSENKIDFN 216

Query: 1132 NFVEHIVTGSQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHP 1191
            +F++ + TG       C A   V +K               I   SK  N     H +H 
Sbjct: 217  DFIKRLKTGK------CSAFPDVPDK-----------ENFEIPIYSKEPNSASSTHQMH- 258

Query: 1192 INQYLRKQSHEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSH 1251
                +  +  E  S IT+    + R+       +  +  +  T+     + N+ E+K + 
Sbjct: 259  ----VSLKEDENNSNITR----LFREKDDGMNFTQCHTANIQTLIPTSSETNSRESKGND 310

Query: 1252 FQALGDDISRTVIPS--EVLPSAGAFSKSEGQHENFLNISR--LQEKTGTYTTNKTKNN 1306
                G+D          ++LP+ G FS+ E Q +N ++++     + +G  T  K+K N
Sbjct: 311  ITIYGNDFMDLTFNHTLQILPATGNFSEIENQTQNAMDVTTGYGTKASGNKTVFKSKQN 369


>gi|40068059 CBF1 interacting corepressor [Homo sapiens]
          Length = 450

 Score = 38.1 bits (87), Expect = 0.11
 Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 24/155 (15%)

Query: 906  SSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREH 965
            SS+ S + S +E  E +  S++ +  KK+  K +     S     +S +  +D +K R+ 
Sbjct: 261  SSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGH--NNSDSEEKDKSKKRKL 318

Query: 966  TSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFSQKT-- 1023
                + +  N             R++A     KEKP   ++E    D K   + S K   
Sbjct: 319  HEELSSSHHN-------------REKA-----KEKPRFLKHESSREDSKWSHSDSDKKSR 360

Query: 1024 --KKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSP 1056
              K +P    SE+   S RS  R +  +RSR  SP
Sbjct: 361  THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSP 395


>gi|51339291 sterile alpha motif domain containing 9-like [Homo
           sapiens]
          Length = 1584

 Score = 38.1 bits (87), Expect = 0.11
 Identities = 30/120 (25%), Positives = 52/120 (43%), Gaps = 13/120 (10%)

Query: 870 LTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSESEVKEHT--FISQT 927
           L   E   L+++E   + ++DLVEMG+ W P  L+  S   L     E   H    +  +
Sbjct: 37  LLSEEVTGLVLQE---LTEKDLVEMGLPWGPALLIKRSYNKLNSKSPESDNHDPGQLDNS 93

Query: 928 KSS------YKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREHTSSFNCNFQNGNQEHQ 981
           K S        K T K + N++ S+  I + P  ++D+ +        N   +  N +H+
Sbjct: 94  KPSKTEHQKNPKHTKKEEENSMSSN--IDYDPREIRDIKQEESILMKENVLDEVANAKHK 151


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,803,041
Number of Sequences: 37866
Number of extensions: 4301921
Number of successful extensions: 12489
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 86
Number of HSP's that attempted gapping in prelim test: 12307
Number of HSP's gapped (non-prelim): 224
length of query: 2590
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2471
effective length of database: 13,741,464
effective search space: 33955157544
effective search space used: 33955157544
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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