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Search of human proteins with 7662404
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662404 caspase recruitment domain family, member 8 [Homo
sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662404 caspase recruitment domain family, member 8 [Homo sap... 871 0.0
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 303 3e-82
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 303 3e-82
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 271 6e-73
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 248 8e-66
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 248 8e-66
gi|40788015 caspase recruitment domain protein 12 [Homo sapiens] 43 6e-04
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 41 0.002
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 41 0.002
gi|62953113 caspase-1 dominant-negative inhibitor pseudo-ICE iso... 41 0.002
gi|16751833 caspase-1 dominant-negative inhibitor pseudo-ICE iso... 41 0.002
gi|10835256 PYD and CARD domain containing isoform a [Homo sapiens] 41 0.002
gi|55925612 caspase recruitment domain family, member 17 [Homo s... 39 0.007
gi|22035620 PYD and CARD domain containing isoform b [Homo sapiens] 39 0.009
gi|21735548 centrosomal protein 2 [Homo sapiens] 35 0.10
gi|16554564 caspase recruitment domain family, member 6 [Homo sa... 33 0.38
gi|10954343 ICEBERG caspase-1 inhibitor [Homo sapiens] 33 0.50
gi|116686122 kinesin family member 4 [Homo sapiens] 33 0.50
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 33 0.65
gi|33946285 baculoviral IAP repeat-containing protein 3 [Homo sa... 32 0.85
gi|4502139 baculoviral IAP repeat-containing protein 3 [Homo sap... 32 0.85
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens] 32 0.85
gi|39995061 caspase 2 isoform 3 [Homo sapiens] 31 1.9
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 30 3.2
gi|189217904 RPGRIP1-like isoform b [Homo sapiens] 30 3.2
gi|118442834 RPGRIP1-like isoform a [Homo sapiens] 30 3.2
gi|54124343 hypothetical protein LOC387680 [Homo sapiens] 30 4.2
gi|59814411 hypothetical protein LOC253725 [Homo sapiens] 30 4.2
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 30 4.2
gi|154090959 hypothetical protein LOC55747 [Homo sapiens] 30 4.2
>gi|7662404 caspase recruitment domain family, member 8 [Homo
sapiens]
Length = 431
Score = 871 bits (2251), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MMRQRQSHYCSVLFLSVNYLGGTFPGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPE 60
MMRQRQSHYCSVLFLSVNYLGGTFPGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPE
Sbjct: 1 MMRQRQSHYCSVLFLSVNYLGGTFPGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPE 60
Query: 61 GNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHH 120
GNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHH
Sbjct: 61 GNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHH 120
Query: 121 EQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQGEVDVSWFLVAHFKNEGMVLEHPARVEP 180
EQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQGEVDVSWFLVAHFKNEGMVLEHPARVEP
Sbjct: 121 EQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQGEVDVSWFLVAHFKNEGMVLEHPARVEP 180
Query: 181 FYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKA 240
FYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKA
Sbjct: 181 FYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKA 240
Query: 241 IDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFY 300
IDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFY
Sbjct: 241 IDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFY 300
Query: 301 AGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMG 360
AGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMG
Sbjct: 301 AGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMG 360
Query: 361 DLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDP 420
DLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDP
Sbjct: 361 DLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDP 420
Query: 421 YLVSYLRQQNL 431
YLVSYLRQQNL
Sbjct: 421 YLVSYLRQQNL 431
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 303 bits (775), Expect = 3e-82
Identities = 171/384 (44%), Positives = 231/384 (60%), Gaps = 16/384 (4%)
Query: 56 FLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLAL 115
F GP G V E++DK N Y V FP AG Y W TGL F++R+ VTV I F W Q L
Sbjct: 1049 FWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLG- 1107
Query: 116 DLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQG-EVDVSWFLVAHFKNEGMVLEH 174
++ W+V GPL D+ AEP AV +HLPHF++LQG VD S F +AHFK EGM+LE
Sbjct: 1108 EINPQHSWMVAGPLLDIKAEPG-AVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1166
Query: 175 PARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSD 234
PARVE + VLE+PSFS +G+LL++ IP+TS L+Y+ HPE++ FHLYL+PSD
Sbjct: 1167 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1226
Query: 235 ALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSAN--LKVMPKELKLSYRSPGE 292
+ KAIDD E +F VR+ PP+ PL G Y VS S + L+++PKEL+L YRSPGE
Sbjct: 1227 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1286
Query: 293 IQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPP-------PFSGA 345
Q FS+FY G + I+L++ +K+ TLVW+ VKP DL PP P
Sbjct: 1287 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAP 1346
Query: 346 A---FVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEK 402
FV + QL AR+ ++ VLD L +VL++ + E V E TR S+ L S+ +
Sbjct: 1347 QLLHFVDQYREQLIARVTSVEVVLDKLH-GQVLSQEQYERVLAENTRPSQMRKLFSLSQS 1405
Query: 403 KGDLALDVLFRSISERDPYLVSYL 426
D L++++ E P+L+ L
Sbjct: 1406 WDRKCKDGLYQALKETHPHLIMEL 1429
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 303 bits (775), Expect = 3e-82
Identities = 171/384 (44%), Positives = 231/384 (60%), Gaps = 16/384 (4%)
Query: 56 FLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLAL 115
F GP G V E++DK N Y V FP AG Y W TGL F++R+ VTV I F W Q L
Sbjct: 1079 FWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLG- 1137
Query: 116 DLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQG-EVDVSWFLVAHFKNEGMVLEH 174
++ W+V GPL D+ AEP AV +HLPHF++LQG VD S F +AHFK EGM+LE
Sbjct: 1138 EINPQHSWMVAGPLLDIKAEPG-AVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1196
Query: 175 PARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSD 234
PARVE + VLE+PSFS +G+LL++ IP+TS L+Y+ HPE++ FHLYL+PSD
Sbjct: 1197 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1256
Query: 235 ALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSAN--LKVMPKELKLSYRSPGE 292
+ KAIDD E +F VR+ PP+ PL G Y VS S + L+++PKEL+L YRSPGE
Sbjct: 1257 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1316
Query: 293 IQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPP-------PFSGA 345
Q FS+FY G + I+L++ +K+ TLVW+ VKP DL PP P
Sbjct: 1317 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAP 1376
Query: 346 A---FVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEK 402
FV + QL AR+ ++ VLD L +VL++ + E V E TR S+ L S+ +
Sbjct: 1377 QLLHFVDQYREQLIARVTSVEVVLDKLH-GQVLSQEQYERVLAENTRPSQMRKLFSLSQS 1435
Query: 403 KGDLALDVLFRSISERDPYLVSYL 426
D L++++ E P+L+ L
Sbjct: 1436 WDRKCKDGLYQALKETHPHLIMEL 1459
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 271 bits (694), Expect = 6e-73
Identities = 140/276 (50%), Positives = 183/276 (66%), Gaps = 5/276 (1%)
Query: 56 FLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLAL 115
F GP G V E++DK N Y V FP AG Y W TGL F++R+ VTV I F W Q L
Sbjct: 1083 FWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLG- 1141
Query: 116 DLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQG-EVDVSWFLVAHFKNEGMVLEH 174
++ W+V GPL D+ AEP AV +HLPHF++LQG VD S F +AHFK EGM+LE
Sbjct: 1142 EINPQHSWMVAGPLLDIKAEPG-AVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1200
Query: 175 PARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSD 234
PARVE + VLE+PSFS +G+LL++ IP+TS L+Y+ HPE++ FHLYL+PSD
Sbjct: 1201 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1260
Query: 235 ALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSAN--LKVMPKELKLSYRSPGE 292
+ KAIDD E +F VR+ PP+ PL G Y VS S + L+++PKEL+L YRSPGE
Sbjct: 1261 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1320
Query: 293 IQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKP 328
Q FS+FY G + I+L++ +K+ TLVW+ VKP
Sbjct: 1321 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKP 1356
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 248 bits (633), Expect = 8e-66
Identities = 151/382 (39%), Positives = 204/382 (53%), Gaps = 56/382 (14%)
Query: 56 FLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLAL 115
F GP G V E++DK N Y V FP AG Y W TGL F++R+ VTV I F W Q L
Sbjct: 1079 FWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLG- 1137
Query: 116 DLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQG-EVDVSWFLVAHFKNEGMVLEH 174
++ W+V GPL D+ AEP AV +HLPHF++LQG VD S F +AHFK EGM+LE
Sbjct: 1138 EINPQHSWMVAGPLLDIKAEPG-AVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1196
Query: 175 PARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSD 234
PARVE + VLE+PSFS +G+LL++ IP+TS L+Y+ HPE++ FHLYL+PSD
Sbjct: 1197 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1256
Query: 235 ALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQ 294
+ K EL+L YRSPGE Q
Sbjct: 1257 CSIRK------------------------------------------ELELCYRSPGEDQ 1274
Query: 295 HFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPP-------PFSGAA- 346
FS+FY G + I+L++ +K+ TLVW+ VKP DL PP P
Sbjct: 1275 LFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQL 1334
Query: 347 --FVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKG 404
FV + QL AR+ ++ VLD L +VL++ + E V E TR S+ L S+ +
Sbjct: 1335 LHFVDQYREQLIARVTSVEVVLDKLH-GQVLSQEQYERVLAENTRPSQMRKLFSLSQSWD 1393
Query: 405 DLALDVLFRSISERDPYLVSYL 426
D L++++ E P+L+ L
Sbjct: 1394 RKCKDGLYQALKETHPHLIMEL 1415
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 248 bits (633), Expect = 8e-66
Identities = 151/382 (39%), Positives = 204/382 (53%), Gaps = 56/382 (14%)
Query: 56 FLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLAL 115
F GP G V E++DK N Y V FP AG Y W TGL F++R+ VTV I F W Q L
Sbjct: 1049 FWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLG- 1107
Query: 116 DLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQG-EVDVSWFLVAHFKNEGMVLEH 174
++ W+V GPL D+ AEP AV +HLPHF++LQG VD S F +AHFK EGM+LE
Sbjct: 1108 EINPQHSWMVAGPLLDIKAEPG-AVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1166
Query: 175 PARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSD 234
PARVE + VLE+PSFS +G+LL++ IP+TS L+Y+ HPE++ FHLYL+PSD
Sbjct: 1167 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1226
Query: 235 ALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQ 294
+ K EL+L YRSPGE Q
Sbjct: 1227 CSIRK------------------------------------------ELELCYRSPGEDQ 1244
Query: 295 HFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPP-------PFSGAA- 346
FS+FY G + I+L++ +K+ TLVW+ VKP DL PP P
Sbjct: 1245 LFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQL 1304
Query: 347 --FVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKG 404
FV + QL AR+ ++ VLD L +VL++ + E V E TR S+ L S+ +
Sbjct: 1305 LHFVDQYREQLIARVTSVEVVLDKLH-GQVLSQEQYERVLAENTRPSQMRKLFSLSQSWD 1363
Query: 405 DLALDVLFRSISERDPYLVSYL 426
D L++++ E P+L+ L
Sbjct: 1364 RKCKDGLYQALKETHPHLIMEL 1385
>gi|40788015 caspase recruitment domain protein 12 [Homo sapiens]
Length = 1024
Score = 42.7 bits (99), Expect = 6e-04
Identities = 28/87 (32%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 347 FVKENHRQLQARMGD--LKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKG 404
F+K+N R L RMG +K + DDL VL E ++ EK Q ++ M+ KKG
Sbjct: 3 FIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILKKG 62
Query: 405 DLALDVLFRSISERDPYLVSYLRQQNL 431
+ ++ +S+ E + L L Q+L
Sbjct: 63 SESCNLFLKSLKEWNYPLFQDLNGQSL 89
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 41.2 bits (95), Expect = 0.002
Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 348 VKENHRQLQARMGD--LKGVLDDLQDNEVLTENEKELVEQEK-TRQSKNEALLSMVEKKG 404
+KE + MG+ + G+LD+L VL + E E V++E T K AL+ V KG
Sbjct: 6 LKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKG 65
Query: 405 DLALDVLFRSISERDPYLVSYL 426
A + I E D YL L
Sbjct: 66 AQACQICITYICEEDSYLAGTL 87
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 41.2 bits (95), Expect = 0.002
Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 348 VKENHRQLQARMGD--LKGVLDDLQDNEVLTENEKELVEQEK-TRQSKNEALLSMVEKKG 404
+KE + MG+ + G+LD+L VL + E E V++E T K AL+ V KG
Sbjct: 6 LKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKG 65
Query: 405 DLALDVLFRSISERDPYLVSYL 426
A + I E D YL L
Sbjct: 66 AQACQICITYICEEDSYLAGTL 87
>gi|62953113 caspase-1 dominant-negative inhibitor pseudo-ICE
isoform 1 [Homo sapiens]
Length = 197
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/68 (36%), Positives = 33/68 (48%), Gaps = 1/68 (1%)
Query: 360 GDLKGVLDDLQDNEVLTENEKELVEQEK-TRQSKNEALLSMVEKKGDLALDVLFRSISER 418
G + G+LD+L VL + E E V++E T K AL+ V KG A + I E
Sbjct: 20 GTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEE 79
Query: 419 DPYLVSYL 426
D YL L
Sbjct: 80 DSYLAETL 87
>gi|16751833 caspase-1 dominant-negative inhibitor pseudo-ICE
isoform 2 [Homo sapiens]
Length = 97
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/68 (36%), Positives = 33/68 (48%), Gaps = 1/68 (1%)
Query: 360 GDLKGVLDDLQDNEVLTENEKELVEQEK-TRQSKNEALLSMVEKKGDLALDVLFRSISER 418
G + G+LD+L VL + E E V++E T K AL+ V KG A + I E
Sbjct: 20 GTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEE 79
Query: 419 DPYLVSYL 426
D YL L
Sbjct: 80 DSYLAETL 87
>gi|10835256 PYD and CARD domain containing isoform a [Homo sapiens]
Length = 195
Score = 40.8 bits (94), Expect = 0.002
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 3/101 (2%)
Query: 328 PVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEK 387
P +Q SA P G F+ ++ L AR+ +++ +LD L +VLT+ + + V E
Sbjct: 97 PAGIQAPPQSAAKP--GLHFIDQHRAALIARVTNVEWLLDALY-GKVLTDEQYQAVRAEP 153
Query: 388 TRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQ 428
T SK L S D+L +++ E YLV L +
Sbjct: 154 TNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLER 194
>gi|55925612 caspase recruitment domain family, member 17 [Homo
sapiens]
Length = 110
Score = 39.3 bits (90), Expect = 0.007
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 3/82 (3%)
Query: 348 VKENHRQLQARMGD--LKGVLDDLQDNEVLTENEKELVEQEK-TRQSKNEALLSMVEKKG 404
+KE +Q +G+ + G+L +L + VL++ E E+V+ E T K ALL V +KG
Sbjct: 6 LKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDSVIRKG 65
Query: 405 DLALDVLFRSISERDPYLVSYL 426
A + I E D +L L
Sbjct: 66 APACQICITYICEEDSHLAGTL 87
>gi|22035620 PYD and CARD domain containing isoform b [Homo sapiens]
Length = 176
Score = 38.9 bits (89), Expect = 0.009
Identities = 37/156 (23%), Positives = 68/156 (43%), Gaps = 9/156 (5%)
Query: 281 KELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITEK-------RHGTLVWDTEVKPVDLQL 333
K+ KL S + + + G + L++T+K +G + ++ + LQ
Sbjct: 21 KKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTANVLRDMGLQE 80
Query: 334 VAASAPPP-FSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSK 392
+A G F+ ++ L AR+ +++ +LD L +VLT+ + + V E T SK
Sbjct: 81 MAGQLQAATHQGLHFIDQHRAALIARVTNVEWLLDALY-GKVLTDEQYQAVRAEPTNPSK 139
Query: 393 NEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQ 428
L S D+L +++ E YLV L +
Sbjct: 140 MRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLER 175
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 35.4 bits (80), Expect = 0.10
Identities = 29/134 (21%), Positives = 68/134 (50%), Gaps = 6/134 (4%)
Query: 303 QMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDL 362
++++ ++++ +++ T + T+++ +L A+ AA +E+ LQ +M DL
Sbjct: 950 RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM-DL 1008
Query: 363 KGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYL 422
+ ++DL+ V ++ + LVEQE + + + ++K+ + L S+ E++ L
Sbjct: 1009 QKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRL 1068
Query: 423 V-----SYLRQQNL 431
+ +RQQ L
Sbjct: 1069 LVLQEADSIRQQEL 1082
>gi|16554564 caspase recruitment domain family, member 6 [Homo
sapiens]
Length = 1037
Score = 33.5 bits (75), Expect = 0.38
Identities = 17/57 (29%), Positives = 29/57 (50%)
Query: 349 KENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGD 405
+E + L+ D +LD L +++E E E +E K+ LL +V+KKG+
Sbjct: 13 RERKKLLEILQHDPDSILDTLTSRRLISEEEYETLENVTDLLKKSRKLLILVQKKGE 69
>gi|10954343 ICEBERG caspase-1 inhibitor [Homo sapiens]
Length = 90
Score = 33.1 bits (74), Expect = 0.50
Identities = 19/66 (28%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 360 GDLKGVLDDLQDNEVLTENEKELVEQEK-TRQSKNEALLSMVEKKGDLALDVLFRSISER 418
G + +LD L ++EV+++ + V E T K L+ +V KG + + + E
Sbjct: 20 GTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEE 79
Query: 419 DPYLVS 424
DP L S
Sbjct: 80 DPQLAS 85
>gi|116686122 kinesin family member 4 [Homo sapiens]
Length = 1232
Score = 33.1 bits (74), Expect = 0.50
Identities = 24/80 (30%), Positives = 46/80 (57%), Gaps = 3/80 (3%)
Query: 353 RQLQARMGDLKGVLDDLQDN--EVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDV 410
+Q + D++ +L + +++ E+ TE + ELV E+ Q K LLS ++ + +A
Sbjct: 889 KQSKTSCADMQKMLFEERNHFAEIETELQAELVRMEQQHQEKVLYLLSQLQ-QSQMAEKQ 947
Query: 411 LFRSISERDPYLVSYLRQQN 430
L S+SE++ L+S L+ Q+
Sbjct: 948 LEESVSEKEQQLLSTLKCQD 967
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 32.7 bits (73), Expect = 0.65
Identities = 17/68 (25%), Positives = 38/68 (55%)
Query: 350 ENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALD 409
+ +R + A+ L +L+ L + +++T +EL++ + S+N LL+++ K+G A D
Sbjct: 41 KKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFD 100
Query: 410 VLFRSISE 417
++ E
Sbjct: 101 AFCEALRE 108
>gi|33946285 baculoviral IAP repeat-containing protein 3 [Homo
sapiens]
Length = 604
Score = 32.3 bits (72), Expect = 0.85
Identities = 17/79 (21%), Positives = 38/79 (48%)
Query: 348 VKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLA 407
+++N L + + +LD L ++ E E ++++Q+ + L+ + KG++A
Sbjct: 447 IRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIA 506
Query: 408 LDVLFRSISERDPYLVSYL 426
V S+ E + L +L
Sbjct: 507 ATVFRNSLQEAEAVLYEHL 525
>gi|4502139 baculoviral IAP repeat-containing protein 3 [Homo
sapiens]
Length = 604
Score = 32.3 bits (72), Expect = 0.85
Identities = 17/79 (21%), Positives = 38/79 (48%)
Query: 348 VKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLA 407
+++N L + + +LD L ++ E E ++++Q+ + L+ + KG++A
Sbjct: 447 IRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIA 506
Query: 408 LDVLFRSISERDPYLVSYL 426
V S+ E + L +L
Sbjct: 507 ATVFRNSLQEAEAVLYEHL 525
>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
Length = 1219
Score = 32.3 bits (72), Expect = 0.85
Identities = 33/128 (25%), Positives = 58/128 (45%), Gaps = 11/128 (8%)
Query: 292 EIQHFS-KFYAGQMKEP-IQLEITEKRHGT-----LVWDTEVKPVDLQLVAASAPPPFSG 344
++ H K A Q KE +Q+++TE T + + K +LQ + A F
Sbjct: 651 QVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKS 710
Query: 345 AAFVKENHRQLQARMGDLKGVLDDLQ-DNEVLTENEKELVEQEKTRQSKNEALLSMVEKK 403
K+N +QL+ ++ L+ L DL+ + E L +N E ++ +S+ E + + K
Sbjct: 711 E---KQNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKS 767
Query: 404 GDLALDVL 411
LD L
Sbjct: 768 YQEELDKL 775
>gi|39995061 caspase 2 isoform 3 [Homo sapiens]
Length = 108
Score = 31.2 bits (69), Expect = 1.9
Identities = 16/66 (24%), Positives = 37/66 (56%)
Query: 350 ENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALD 409
+ +R + A+ L +L+ L + +++T +EL++ + S+N LL+++ K+G A D
Sbjct: 41 KKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFD 100
Query: 410 VLFRSI 415
++
Sbjct: 101 AFCEAL 106
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 30.4 bits (67), Expect = 3.2
Identities = 51/213 (23%), Positives = 84/213 (39%), Gaps = 30/213 (14%)
Query: 221 PED--IKFHLYLVPSDALLTKAIDDEED------RFHGVRLQTSPP--MEPLNFGSSYIV 270
P+D +K H P D+L+ A + V +Q P + P++ G
Sbjct: 246 PKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMD-GQDQAP 304
Query: 271 SNSANLKVMPKELKLSYRSPGEIQHFSKFYAGQMKEPIQ-LEITEKRHGTLVWDTEVKPV 329
S S LK +P++ + +++ +K ++K P Q +E T + EV V
Sbjct: 305 SESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQT--------YSNEVHCV 356
Query: 330 D--LQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEK 387
+ L+ + S PPP + H A D Q +T+N+K+ K
Sbjct: 357 EEILKEMTHSWPPPLTAI------HTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSK 410
Query: 388 TRQSKNEALLSMVEKKGDLALDVLFRSISERDP 420
T + + SM+E DL L S SE+ P
Sbjct: 411 THSNSQQGTSSMLE--DDLQLSDSEDSDSEQTP 441
>gi|189217904 RPGRIP1-like isoform b [Homo sapiens]
Length = 1235
Score = 30.4 bits (67), Expect = 3.2
Identities = 47/188 (25%), Positives = 76/188 (40%), Gaps = 19/188 (10%)
Query: 222 EDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPK 281
E IK H LV + A+ E +F +Q L +++N L + K
Sbjct: 267 EMIKLHKQLVEK----SNALSAMEGKF----IQLQEKQRTLRISHDALMANGDELNMQLK 318
Query: 282 ELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITE-KRHGTLVWDTEVKPVDLQLVAASAPP 340
E +L S + H KF +++E +Q I + ++ L+ + K D AA
Sbjct: 319 EQRLKCCSLEKQLHSMKFSERRIEE-LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ 377
Query: 341 PFSGAAFVKENHRQLQARMGDLKGVL-DDLQDN-EVLTENEKELVEQEKTRQSKNEALLS 398
K +QL+ ++ L+ L DL D E+L + E + EK Q E L
Sbjct: 378 -------WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430
Query: 399 MVEKKGDL 406
+E+K L
Sbjct: 431 YLEQKQQL 438
>gi|118442834 RPGRIP1-like isoform a [Homo sapiens]
Length = 1315
Score = 30.4 bits (67), Expect = 3.2
Identities = 47/188 (25%), Positives = 76/188 (40%), Gaps = 19/188 (10%)
Query: 222 EDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPK 281
E IK H LV + A+ E +F +Q L +++N L + K
Sbjct: 267 EMIKLHKQLVEK----SNALSAMEGKF----IQLQEKQRTLRISHDALMANGDELNMQLK 318
Query: 282 ELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITE-KRHGTLVWDTEVKPVDLQLVAASAPP 340
E +L S + H KF +++E +Q I + ++ L+ + K D AA
Sbjct: 319 EQRLKCCSLEKQLHSMKFSERRIEE-LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ 377
Query: 341 PFSGAAFVKENHRQLQARMGDLKGVL-DDLQDN-EVLTENEKELVEQEKTRQSKNEALLS 398
K +QL+ ++ L+ L DL D E+L + E + EK Q E L
Sbjct: 378 -------WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430
Query: 399 MVEKKGDL 406
+E+K L
Sbjct: 431 YLEQKQQL 438
>gi|54124343 hypothetical protein LOC387680 [Homo sapiens]
Length = 1341
Score = 30.0 bits (66), Expect = 4.2
Identities = 17/52 (32%), Positives = 27/52 (51%)
Query: 368 DLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERD 419
D + E + + E E EQEKTR+ K L+ V++ + L VL + + D
Sbjct: 101 DEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLD 152
>gi|59814411 hypothetical protein LOC253725 [Homo sapiens]
Length = 1318
Score = 30.0 bits (66), Expect = 4.2
Identities = 17/52 (32%), Positives = 27/52 (51%)
Query: 368 DLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERD 419
D + E + + E E EQEKTR+ K L+ V++ + L VL + + D
Sbjct: 101 DEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLD 152
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 30.0 bits (66), Expect = 4.2
Identities = 13/37 (35%), Positives = 25/37 (67%)
Query: 348 VKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVE 384
++ ++ +LQAR+G+L+G +D L +NEK ++E
Sbjct: 743 LQTHYDELQARLGELQGEAASREDTICLLQNEKIILE 779
>gi|154090959 hypothetical protein LOC55747 [Homo sapiens]
Length = 1253
Score = 30.0 bits (66), Expect = 4.2
Identities = 17/52 (32%), Positives = 27/52 (51%)
Query: 368 DLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERD 419
D + E + + E E EQEKTR+ K L+ V++ + L VL + + D
Sbjct: 13 DEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLD 64
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,290,633
Number of Sequences: 37866
Number of extensions: 790021
Number of successful extensions: 2376
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 2319
Number of HSP's gapped (non-prelim): 68
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.