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Search of human proteins with 7662394
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662394 RAB11 family interacting protein 2 (class I) [Homo
sapiens]
(512 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662394 RAB11 family interacting protein 2 (class I) [Homo sa... 1023 0.0
gi|50659104 RAB11 family interacting protein 1 isoform 3 [Homo s... 253 3e-67
gi|50363228 RAB11 family interacting protein 1 isoform 1 [Homo s... 253 3e-67
gi|24308075 RAB11 family interacting protein 5 (class I) [Homo s... 198 9e-51
gi|50363230 RAB11 family interacting protein 1 isoform 2 [Homo s... 84 4e-16
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 56 7e-08
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 56 7e-08
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 56 7e-08
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 56 7e-08
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 56 7e-08
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 56 7e-08
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 52 1e-06
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 52 1e-06
gi|122937514 unc-13 homolog C [Homo sapiens] 51 2e-06
gi|122937247 unc-13 homolog A [Homo sapiens] 51 2e-06
gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens] 50 5e-06
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens] 50 5e-06
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens] 50 5e-06
gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens] 50 5e-06
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens] 50 5e-06
gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens] 50 5e-06
gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens] 50 5e-06
gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens] 50 5e-06
gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens] 50 5e-06
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens] 50 5e-06
gi|4759026 RAS protein activator like 1 [Homo sapiens] 49 8e-06
gi|209447073 synaptotagmin I [Homo sapiens] 49 1e-05
gi|5032139 synaptotagmin I [Homo sapiens] 49 1e-05
gi|209447070 synaptotagmin I [Homo sapiens] 49 1e-05
gi|211059429 synaptotagmin II [Homo sapiens] 48 2e-05
>gi|7662394 RAB11 family interacting protein 2 (class I) [Homo
sapiens]
Length = 512
Score = 1023 bits (2645), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 1 MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVW 60
MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVW
Sbjct: 1 MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVW 60
Query: 61 KEEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWF 120
KEEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWF
Sbjct: 61 KEEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWF 120
Query: 121 RLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTF 180
RLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTF
Sbjct: 121 RLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTF 180
Query: 181 SDTSSAIIPSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSSAHSMSDLSGSHMSSEK 240
SDTSSAIIPSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSSAHSMSDLSGSHMSSEK
Sbjct: 181 SDTSSAIIPSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSSAHSMSDLSGSHMSSEK 240
Query: 241 LKAGTIGQTHLLGHQLDSFGTVPESGSLKSPHRRTLSFDTSKMNQPDSIVDEGELCFGRQ 300
LKAGTIGQTHLLGHQLDSFGTVPESGSLKSPHRRTLSFDTSKMNQPDSIVDEGELCFGRQ
Sbjct: 241 LKAGTIGQTHLLGHQLDSFGTVPESGSLKSPHRRTLSFDTSKMNQPDSIVDEGELCFGRQ 300
Query: 301 NDPFTNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSKPIEIRKENKREKREKVSLF 360
NDPFTNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSKPIEIRKENKREKREKVSLF
Sbjct: 301 NDPFTNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSKPIEIRKENKREKREKVSLF 360
Query: 361 ERVTGKKDSRRSDKLNNGGSDSPCDLKSPNAFSENRQDYFDYESTNPFTAKFRASNIMPS 420
ERVTGKKDSRRSDKLNNGGSDSPCDLKSPNAFSENRQDYFDYESTNPFTAKFRASNIMPS
Sbjct: 361 ERVTGKKDSRRSDKLNNGGSDSPCDLKSPNAFSENRQDYFDYESTNPFTAKFRASNIMPS 420
Query: 421 SSFHMSPTSNEDLRKIPDSNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDY 480
SSFHMSPTSNEDLRKIPDSNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDY
Sbjct: 421 SSFHMSPTSNEDLRKIPDSNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDY 480
Query: 481 IDNLLVRVMEETPSILRVPYEPSRKAGKFSNS 512
IDNLLVRVMEETPSILRVPYEPSRKAGKFSNS
Sbjct: 481 IDNLLVRVMEETPSILRVPYEPSRKAGKFSNS 512
>gi|50659104 RAB11 family interacting protein 1 isoform 3 [Homo
sapiens]
Length = 1283
Score = 253 bits (646), Expect = 3e-67
Identities = 160/345 (46%), Positives = 208/345 (60%), Gaps = 21/345 (6%)
Query: 10 WFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTL-EPVWKEEASFEL 68
W PTHVQVTVLQA+ L+ KG GT+D Y +IQ+GKEKY+TSV+E++L PVW+EEA+FEL
Sbjct: 15 WSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFEL 74
Query: 69 PGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGK 128
P LL G L L V+HR+L+GLDKFLG+ ++L D+ D+ RRKT+W++L+SK GK
Sbjct: 75 PSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGK 134
Query: 129 RIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTFSDTSSAII 188
+ K RGEI+V+IQFMRNNMTASMFDLSMKDK+R+PF KLKDK+KG KN + SDT+SAII
Sbjct: 135 KDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKG-KNKDSGSDTASAII 193
Query: 189 PSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSS---AHSMSDLSGSHMSSEKLKAGT 245
PST P +S+ S K K K LL L + SMS L S L+ G
Sbjct: 194 PST-TPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGD 252
Query: 246 IGQTHLLGHQLDSFGTVPESGSLKS--PHRRTLSFDTSKMNQPDSIVDEGE-LCF----G 298
Q D ES S H+RT S D ++NQ + + + E L F
Sbjct: 253 FQS------QWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLR 306
Query: 299 RQNDPF--TNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSK 341
+ND +NV + + P K ++SS + S F K
Sbjct: 307 SKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRK 351
Score = 83.6 bits (205), Expect = 4e-16
Identities = 38/69 (55%), Positives = 53/69 (76%)
Query: 440 NPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVP 499
+P D Y LT++E++Q ++K KE + +K+ +RELEDYIDNLLVRVMEETP+ILR+P
Sbjct: 1214 SPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIP 1273
Query: 500 YEPSRKAGK 508
+ +KAGK
Sbjct: 1274 TQVGKKAGK 1282
>gi|50363228 RAB11 family interacting protein 1 isoform 1 [Homo
sapiens]
Length = 649
Score = 253 bits (646), Expect = 3e-67
Identities = 160/345 (46%), Positives = 208/345 (60%), Gaps = 21/345 (6%)
Query: 10 WFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTL-EPVWKEEASFEL 68
W PTHVQVTVLQA+ L+ KG GT+D Y +IQ+GKEKY+TSV+E++L PVW+EEA+FEL
Sbjct: 15 WSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFEL 74
Query: 69 PGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGK 128
P LL G L L V+HR+L+GLDKFLG+ ++L D+ D+ RRKT+W++L+SK GK
Sbjct: 75 PSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGK 134
Query: 129 RIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTFSDTSSAII 188
+ K RGEI+V+IQFMRNNMTASMFDLSMKDK+R+PF KLKDK+KG KN + SDT+SAII
Sbjct: 135 KDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKG-KNKDSGSDTASAII 193
Query: 189 PSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSS---AHSMSDLSGSHMSSEKLKAGT 245
PST P +S+ S K K K LL L + SMS L S L+ G
Sbjct: 194 PST-TPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGD 252
Query: 246 IGQTHLLGHQLDSFGTVPESGSLKS--PHRRTLSFDTSKMNQPDSIVDEGE-LCF----G 298
Q D ES S H+RT S D ++NQ + + + E L F
Sbjct: 253 FQS------QWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLR 306
Query: 299 RQNDPF--TNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSK 341
+ND +NV + + P K ++SS + S F K
Sbjct: 307 SKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRK 351
Score = 83.6 bits (205), Expect = 4e-16
Identities = 38/69 (55%), Positives = 53/69 (76%)
Query: 440 NPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVP 499
+P D Y LT++E++Q ++K KE + +K+ +RELEDYIDNLLVRVMEETP+ILR+P
Sbjct: 580 SPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIP 639
Query: 500 YEPSRKAGK 508
+ +KAGK
Sbjct: 640 TQVGKKAGK 648
>gi|24308075 RAB11 family interacting protein 5 (class I) [Homo
sapiens]
Length = 653
Score = 198 bits (504), Expect = 9e-51
Identities = 129/315 (40%), Positives = 177/315 (56%), Gaps = 38/315 (12%)
Query: 9 KWFPTHVQVTVLQAKDLKPK--GKSGTNDTYTIIQLGKEKYSTSVAEKTLE-PVWKEEAS 65
+W PTHVQVTVL+A+ L+ K G T+D YT+IQ+G+EKYSTSV EKT P W+EE S
Sbjct: 15 RWLPTHVQVTVLRARGLRGKSSGAGSTSDAYTVIQVGREKYSTSVVEKTHGCPEWREECS 74
Query: 66 FELPGLLIQG-----------------SPEKYILFLIVMHRSLVGLDKFLGQVAINLNDI 108
FELP + G S L L MHRSL+G+DKFLGQ + L+++
Sbjct: 75 FELPPGALDGLLRAQEADAGPAPWAASSAAACELVLTTMHRSLIGVDKFLGQATVALDEV 134
Query: 109 FEDKQRRKTEWFRLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLK 168
F + + T+W++L SK GK+ K RGEI+V IQF RNN++ASMFDLSMKDK RSPF+K++
Sbjct: 135 FGAGRAQHTQWYKLHSKPGKKEKERGEIEVTIQFTRNNLSASMFDLSMKDKPRSPFSKIR 194
Query: 169 DKMKGRKNDGTFSDTSSAIIPSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSSAHSM 228
DKMKG+K +++SAI+PS+ + D + G + K K FL R SS
Sbjct: 195 DKMKGKKKYDL--ESASAILPSSAIEDPD----LGSLGKMGKAKGFFLRNKLRKSSLTQS 248
Query: 229 SDLSGSHMSSEKLKAGTIGQ---THLLGHQLDSFGTVPESG---SLKSP----HRRTLSF 278
+ GS + Q LL + G S +SP H+RT S
Sbjct: 249 NTSLGSDSTLSSASGSLAYQGPGAELLTRSPSRSSWLSTEGGRDSAQSPKLFTHKRTYSD 308
Query: 279 DTSKMN--QPDSIVD 291
+ ++M P +++D
Sbjct: 309 EANQMRVAPPRALLD 323
Score = 67.0 bits (162), Expect = 4e-11
Identities = 29/73 (39%), Positives = 51/73 (69%)
Query: 432 DLRKIPDSNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEE 491
D +++ DS D +A Y LT++E++ L++ + L ++D H++ELE YID LLVR+ME
Sbjct: 581 DTKRLKDSAVLDQSAKYYHLTHDELISLLLQRERELSQRDEHVQELESYIDRLLVRIMET 640
Query: 492 TPSILRVPYEPSR 504
+P++L++P P +
Sbjct: 641 SPTLLQIPPGPPK 653
>gi|50363230 RAB11 family interacting protein 1 isoform 2 [Homo
sapiens]
Length = 612
Score = 83.6 bits (205), Expect = 4e-16
Identities = 38/69 (55%), Positives = 53/69 (76%)
Query: 440 NPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVP 499
+P D Y LT++E++Q ++K KE + +K+ +RELEDYIDNLLVRVMEETP+ILR+P
Sbjct: 543 SPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIP 602
Query: 500 YEPSRKAGK 508
+ +KAGK
Sbjct: 603 TQVGKKAGK 611
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 56.2 bits (134), Expect = 7e-08
Identities = 39/142 (27%), Positives = 72/142 (50%), Gaps = 12/142 (8%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQ 74
++ +VL+A+DL PK ++GT+D + ++ TS+ +K+ P W E FEL +
Sbjct: 63 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQ----E 118
Query: 75 GSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIK--- 131
G+ E L + LV + FLG+V I++ + +Q + WFRL+ Q K +
Sbjct: 119 GAME--ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSRRHDE 174
Query: 132 -NRGEIKVNIQFMRNNMTASMF 152
N G +++ ++ + S +
Sbjct: 175 GNLGSLQLEVRLRDETVLPSSY 196
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 56.2 bits (134), Expect = 7e-08
Identities = 39/142 (27%), Positives = 72/142 (50%), Gaps = 12/142 (8%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQ 74
++ +VL+A+DL PK ++GT+D + ++ TS+ +K+ P W E FEL +
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQ----E 190
Query: 75 GSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIK--- 131
G+ E L + LV + FLG+V I++ + +Q + WFRL+ Q K +
Sbjct: 191 GAME--ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSRRHDE 246
Query: 132 -NRGEIKVNIQFMRNNMTASMF 152
N G +++ ++ + S +
Sbjct: 247 GNLGSLQLEVRLRDETVLPSSY 268
Score = 42.4 bits (98), Expect = 0.001
Identities = 43/169 (25%), Positives = 74/169 (43%), Gaps = 19/169 (11%)
Query: 17 VTVLQAKDLKPKGKSGTNDTYTIIQLGKEKY-STSVAEKTLEPVWKEEASFELPGLLIQG 75
+ +++ K+L K +G++D Y I+++ E T+ KTL P W EE LP
Sbjct: 9 IRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLP------ 62
Query: 76 SPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRL------ESKQGKR 129
P + + VM + D +G+V + D + + W L E QG+
Sbjct: 63 -PTFHAVAFYVMDEDALSRDDVIGKVCLT-RDTIASHPKGFSGWAHLTEVDPDEEVQGE- 119
Query: 130 IKNRGEIKVNIQFMRNNMTA-SMFDLSMKDK--TRSPFAKLKDKMKGRK 175
I R E+ + R + DL+ KD+ T PF +++ K + R+
Sbjct: 120 IHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRE 168
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 56.2 bits (134), Expect = 7e-08
Identities = 39/142 (27%), Positives = 72/142 (50%), Gaps = 12/142 (8%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQ 74
++ +VL+A+DL PK ++GT+D + ++ TS+ +K+ P W E FEL +
Sbjct: 63 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQ----E 118
Query: 75 GSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIK--- 131
G+ E L + LV + FLG+V I++ + +Q + WFRL+ Q K +
Sbjct: 119 GAME--ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSRRHDE 174
Query: 132 -NRGEIKVNIQFMRNNMTASMF 152
N G +++ ++ + S +
Sbjct: 175 GNLGSLQLEVRLRDETVLPSSY 196
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 56.2 bits (134), Expect = 7e-08
Identities = 39/142 (27%), Positives = 72/142 (50%), Gaps = 12/142 (8%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQ 74
++ +VL+A+DL PK ++GT+D + ++ TS+ +K+ P W E FEL +
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQ----E 190
Query: 75 GSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIK--- 131
G+ E L + LV + FLG+V I++ + +Q + WFRL+ Q K +
Sbjct: 191 GAME--ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSRRHDE 246
Query: 132 -NRGEIKVNIQFMRNNMTASMF 152
N G +++ ++ + S +
Sbjct: 247 GNLGSLQLEVRLRDETVLPSSY 268
Score = 42.4 bits (98), Expect = 0.001
Identities = 43/169 (25%), Positives = 74/169 (43%), Gaps = 19/169 (11%)
Query: 17 VTVLQAKDLKPKGKSGTNDTYTIIQLGKEKY-STSVAEKTLEPVWKEEASFELPGLLIQG 75
+ +++ K+L K +G++D Y I+++ E T+ KTL P W EE LP
Sbjct: 9 IRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLP------ 62
Query: 76 SPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRL------ESKQGKR 129
P + + VM + D +G+V + D + + W L E QG+
Sbjct: 63 -PTFHAVAFYVMDEDALSRDDVIGKVCLT-RDTIASHPKGFSGWAHLTEVDPDEEVQGE- 119
Query: 130 IKNRGEIKVNIQFMRNNMTA-SMFDLSMKDK--TRSPFAKLKDKMKGRK 175
I R E+ + R + DL+ KD+ T PF +++ K + R+
Sbjct: 120 IHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRE 168
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 56.2 bits (134), Expect = 7e-08
Identities = 39/142 (27%), Positives = 72/142 (50%), Gaps = 12/142 (8%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQ 74
++ +VL+A+DL PK ++GT+D + ++ TS+ +K+ P W E FEL +
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQ----E 190
Query: 75 GSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIK--- 131
G+ E L + LV + FLG+V I++ + +Q + WFRL+ Q K +
Sbjct: 191 GAME--ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSRRHDE 246
Query: 132 -NRGEIKVNIQFMRNNMTASMF 152
N G +++ ++ + S +
Sbjct: 247 GNLGSLQLEVRLRDETVLPSSY 268
Score = 42.4 bits (98), Expect = 0.001
Identities = 43/169 (25%), Positives = 74/169 (43%), Gaps = 19/169 (11%)
Query: 17 VTVLQAKDLKPKGKSGTNDTYTIIQLGKEKY-STSVAEKTLEPVWKEEASFELPGLLIQG 75
+ +++ K+L K +G++D Y I+++ E T+ KTL P W EE LP
Sbjct: 9 IRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLP------ 62
Query: 76 SPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRL------ESKQGKR 129
P + + VM + D +G+V + D + + W L E QG+
Sbjct: 63 -PTFHAVAFYVMDEDALSRDDVIGKVCLT-RDTIASHPKGFSGWAHLTEVDPDEEVQGE- 119
Query: 130 IKNRGEIKVNIQFMRNNMTA-SMFDLSMKDK--TRSPFAKLKDKMKGRK 175
I R E+ + R + DL+ KD+ T PF +++ K + R+
Sbjct: 120 IHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRE 168
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 56.2 bits (134), Expect = 7e-08
Identities = 39/142 (27%), Positives = 72/142 (50%), Gaps = 12/142 (8%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQ 74
++ +VL+A+DL PK ++GT+D + ++ TS+ +K+ P W E FEL +
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQ----E 190
Query: 75 GSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIK--- 131
G+ E L + LV + FLG+V I++ + +Q + WFRL+ Q K +
Sbjct: 191 GAME--ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQ--EEGWFRLQPDQSKSRRHDE 246
Query: 132 -NRGEIKVNIQFMRNNMTASMF 152
N G +++ ++ + S +
Sbjct: 247 GNLGSLQLEVRLRDETVLPSSY 268
Score = 42.4 bits (98), Expect = 0.001
Identities = 43/169 (25%), Positives = 74/169 (43%), Gaps = 19/169 (11%)
Query: 17 VTVLQAKDLKPKGKSGTNDTYTIIQLGKEKY-STSVAEKTLEPVWKEEASFELPGLLIQG 75
+ +++ K+L K +G++D Y I+++ E T+ KTL P W EE LP
Sbjct: 9 IRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLP------ 62
Query: 76 SPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRL------ESKQGKR 129
P + + VM + D +G+V + D + + W L E QG+
Sbjct: 63 -PTFHAVAFYVMDEDALSRDDVIGKVCLT-RDTIASHPKGFSGWAHLTEVDPDEEVQGE- 119
Query: 130 IKNRGEIKVNIQFMRNNMTA-SMFDLSMKDK--TRSPFAKLKDKMKGRK 175
I R E+ + R + DL+ KD+ T PF +++ K + R+
Sbjct: 120 IHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRE 168
>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
sapiens]
Length = 778
Score = 52.4 bits (124), Expect = 1e-06
Identities = 35/142 (24%), Positives = 69/142 (48%), Gaps = 16/142 (11%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQ 74
V +T+++ +DLK +G +D Y +LG +KY + + KTL P W+E+ F L
Sbjct: 251 VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHL------ 304
Query: 75 GSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNRG 134
++ + + D F+G+ ++L+ + R +T L+ ++G+ G
Sbjct: 305 YEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL----SREQTHKLELQLEEGE-----G 355
Query: 135 EIKVNIQFMRNNMTASMFDLSM 156
+ V + + + T S+ DLS+
Sbjct: 356 HL-VLLVTLTASATVSISDLSV 376
Score = 41.2 bits (95), Expect = 0.002
Identities = 36/145 (24%), Positives = 67/145 (46%), Gaps = 12/145 (8%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQ 74
+QV V++A+ L +G +D + +++L ++ T K L P W + +F + +
Sbjct: 407 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDI--- 463
Query: 75 GSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNRG 134
+L + V FLG+VAI L I +Q+ + L++KQ +G
Sbjct: 464 ----HSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKA----YVLKNKQ-LTGPTKG 514
Query: 135 EIKVNIQFMRNNMTASMFDLSMKDK 159
I + I + N + AS+ L K++
Sbjct: 515 VIYLEIDVIFNAVKASLRTLIPKEQ 539
Score = 38.9 bits (89), Expect = 0.011
Identities = 23/95 (24%), Positives = 46/95 (48%), Gaps = 8/95 (8%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLG-KEKYSTSVAEKTLEPVWKEEASFELPGLLI 73
+ +T+ + + L + + GT+D Y ++G KE + + + K L PVW+E+A + L
Sbjct: 42 LDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHL-- 99
Query: 74 QGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDI 108
+ L++ V D F+G ++L +
Sbjct: 100 -----REPLYIKVFDYDFGLQDDFMGSAFLDLTQL 129
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 52.4 bits (124), Expect = 1e-06
Identities = 35/142 (24%), Positives = 69/142 (48%), Gaps = 16/142 (11%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQ 74
V +T+++ +DLK +G +D Y +LG +KY + + KTL P W+E+ F L
Sbjct: 472 VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHL------ 525
Query: 75 GSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNRG 134
++ + + D F+G+ ++L+ + R +T L+ ++G+ G
Sbjct: 526 YEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL----SREQTHKLELQLEEGE-----G 576
Query: 135 EIKVNIQFMRNNMTASMFDLSM 156
+ V + + + T S+ DLS+
Sbjct: 577 HL-VLLVTLTASATVSISDLSV 597
Score = 41.2 bits (95), Expect = 0.002
Identities = 36/145 (24%), Positives = 67/145 (46%), Gaps = 12/145 (8%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQ 74
+QV V++A+ L +G +D + +++L ++ T K L P W + +F + +
Sbjct: 628 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDI--- 684
Query: 75 GSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNRG 134
+L + V FLG+VAI L I +Q+ + L++KQ +G
Sbjct: 685 ----HSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKA----YVLKNKQ-LTGPTKG 735
Query: 135 EIKVNIQFMRNNMTASMFDLSMKDK 159
I + I + N + AS+ L K++
Sbjct: 736 VIYLEIDVIFNAVKASLRTLIPKEQ 760
Score = 38.9 bits (89), Expect = 0.011
Identities = 23/95 (24%), Positives = 46/95 (48%), Gaps = 8/95 (8%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLG-KEKYSTSVAEKTLEPVWKEEASFELPGLLI 73
+ +T+ + + L + + GT+D Y ++G KE + + + K L PVW+E+A + L
Sbjct: 263 LDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHL-- 320
Query: 74 QGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDI 108
+ L++ V D F+G ++L +
Sbjct: 321 -----REPLYIKVFDYDFGLQDDFMGSAFLDLTQL 350
>gi|122937514 unc-13 homolog C [Homo sapiens]
Length = 2214
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/138 (26%), Positives = 62/138 (44%), Gaps = 10/138 (7%)
Query: 9 KWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFEL 68
KW + +TV+ A+ L+ K K+G++D Y +Q+GK K T L PVW E+ FE
Sbjct: 1217 KW-SAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFEC 1275
Query: 69 PG----LLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLES 124
+ ++ E + V D FLGQ + + + + W+ LE
Sbjct: 1276 HNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMD----VWYNLEK 1331
Query: 125 KQGK-RIKNRGEIKVNIQ 141
+ K + +K+N++
Sbjct: 1332 RTDKSAVSGAIRLKINVE 1349
>gi|122937247 unc-13 homolog A [Homo sapiens]
Length = 1791
Score = 51.2 bits (121), Expect = 2e-06
Identities = 47/184 (25%), Positives = 79/184 (42%), Gaps = 25/184 (13%)
Query: 9 KWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFEL 68
KW + +TV+ A+ L+ K K+G++D Y +Q+GK K T L PVW+E FE
Sbjct: 761 KW-SAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFEC 819
Query: 69 PG----LLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLES 124
+ ++ E + V R D FLGQ I + + + W+ L+
Sbjct: 820 HNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMD----VWYNLDK 875
Query: 125 KQGK-----------RIKNRGEIKV---NIQF--MRNNMTASMFDLSMKDKTRSPFAKLK 168
+ K ++ +GE KV ++Q+ + N+ + D+ + P AK
Sbjct: 876 RTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGD 935
Query: 169 DKMK 172
D K
Sbjct: 936 DAWK 939
Score = 32.7 bits (73), Expect = 0.81
Identities = 27/103 (26%), Positives = 49/103 (47%), Gaps = 9/103 (8%)
Query: 23 KDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQGSPEKYIL 82
K K G +TY +++ K ST++A + +P W+++ FE+ L + L
Sbjct: 97 KKAKFDGAQEKFNTYVTLKVQNVK-STTIAVRGSQPSWEQDFMFEINRLDLG-------L 148
Query: 83 FLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESK 125
+ V ++ L+ D +G V I L I + + EW L+S+
Sbjct: 149 TVEVWNKGLI-WDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQ 190
>gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]
Length = 376
Score = 50.1 bits (118), Expect = 5e-06
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 9/129 (6%)
Query: 20 LQAKDLKPKGKSGTNDTYTIIQLGKE-KYSTSVAEKTLEPVWKEEASFELPGLLIQGSPE 78
L A D+K + Y + GK K T V +KTL PV+ E +++ +++
Sbjct: 97 LAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQK- 155
Query: 79 KYILFLIVMHRSLVGLDKFLGQVAINLND-IFEDKQRRKTEWFRLESKQGK---RIKNRG 134
L L + HR + FLG+V ++L +++KQ ++ W+ L+ K +NRG
Sbjct: 156 ---LNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 212
Query: 135 EIKVNIQFM 143
E+K+ +Q++
Sbjct: 213 EMKLALQYV 221
>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
Length = 910
Score = 50.1 bits (118), Expect = 5e-06
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 9/129 (6%)
Query: 20 LQAKDLKPKGKSGTNDTYTIIQLGKE-KYSTSVAEKTLEPVWKEEASFELPGLLIQGSPE 78
L A D+K + Y + GK K T V +KTL PV+ E +++ +++
Sbjct: 631 LAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQK- 689
Query: 79 KYILFLIVMHRSLVGLDKFLGQVAINLND-IFEDKQRRKTEWFRLESKQGK---RIKNRG 134
L L + HR + FLG+V ++L +++KQ ++ W+ L+ K +NRG
Sbjct: 690 ---LNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 746
Query: 135 EIKVNIQFM 143
E+K+ +Q++
Sbjct: 747 EMKLALQYV 755
>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
Length = 935
Score = 50.1 bits (118), Expect = 5e-06
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 9/129 (6%)
Query: 20 LQAKDLKPKGKSGTNDTYTIIQLGKE-KYSTSVAEKTLEPVWKEEASFELPGLLIQGSPE 78
L A D+K + Y + GK K T V +KTL PV+ E +++ +++
Sbjct: 656 LAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQK- 714
Query: 79 KYILFLIVMHRSLVGLDKFLGQVAINLND-IFEDKQRRKTEWFRLESKQGK---RIKNRG 134
L L + HR + FLG+V ++L +++KQ ++ W+ L+ K +NRG
Sbjct: 715 ---LNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 771
Query: 135 EIKVNIQFM 143
E+K+ +Q++
Sbjct: 772 EMKLALQYV 780
>gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens]
Length = 336
Score = 50.1 bits (118), Expect = 5e-06
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 9/129 (6%)
Query: 20 LQAKDLKPKGKSGTNDTYTIIQLGKE-KYSTSVAEKTLEPVWKEEASFELPGLLIQGSPE 78
L A D+K + Y + GK K T V +KTL PV+ E +++ +++
Sbjct: 57 LAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQK- 115
Query: 79 KYILFLIVMHRSLVGLDKFLGQVAINLND-IFEDKQRRKTEWFRLESKQGK---RIKNRG 134
L L + HR + FLG+V ++L +++KQ ++ W+ L+ K +NRG
Sbjct: 116 ---LNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 172
Query: 135 EIKVNIQFM 143
E+K+ +Q++
Sbjct: 173 EMKLALQYV 181
>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
Length = 934
Score = 50.1 bits (118), Expect = 5e-06
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 9/129 (6%)
Query: 20 LQAKDLKPKGKSGTNDTYTIIQLGKE-KYSTSVAEKTLEPVWKEEASFELPGLLIQGSPE 78
L A D+K + Y + GK K T V +KTL PV+ E +++ +++
Sbjct: 655 LAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQK- 713
Query: 79 KYILFLIVMHRSLVGLDKFLGQVAINLND-IFEDKQRRKTEWFRLESKQGK---RIKNRG 134
L L + HR + FLG+V ++L +++KQ ++ W+ L+ K +NRG
Sbjct: 714 ---LNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 770
Query: 135 EIKVNIQFM 143
E+K+ +Q++
Sbjct: 771 EMKLALQYV 779
>gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens]
Length = 365
Score = 50.1 bits (118), Expect = 5e-06
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 9/129 (6%)
Query: 20 LQAKDLKPKGKSGTNDTYTIIQLGKE-KYSTSVAEKTLEPVWKEEASFELPGLLIQGSPE 78
L A D+K + Y + GK K T V +KTL PV+ E +++ +++
Sbjct: 86 LAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQK- 144
Query: 79 KYILFLIVMHRSLVGLDKFLGQVAINLND-IFEDKQRRKTEWFRLESKQGK---RIKNRG 134
L L + HR + FLG+V ++L +++KQ ++ W+ L+ K +NRG
Sbjct: 145 ---LNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 201
Query: 135 EIKVNIQFM 143
E+K+ +Q++
Sbjct: 202 EMKLALQYV 210
>gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens]
Length = 376
Score = 50.1 bits (118), Expect = 5e-06
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 9/129 (6%)
Query: 20 LQAKDLKPKGKSGTNDTYTIIQLGKE-KYSTSVAEKTLEPVWKEEASFELPGLLIQGSPE 78
L A D+K + Y + GK K T V +KTL PV+ E +++ +++
Sbjct: 97 LAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQK- 155
Query: 79 KYILFLIVMHRSLVGLDKFLGQVAINLND-IFEDKQRRKTEWFRLESKQGK---RIKNRG 134
L L + HR + FLG+V ++L +++KQ ++ W+ L+ K +NRG
Sbjct: 156 ---LNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 212
Query: 135 EIKVNIQFM 143
E+K+ +Q++
Sbjct: 213 EMKLALQYV 221
>gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens]
Length = 1256
Score = 50.1 bits (118), Expect = 5e-06
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 9/129 (6%)
Query: 20 LQAKDLKPKGKSGTNDTYTIIQLGKE-KYSTSVAEKTLEPVWKEEASFELPGLLIQGSPE 78
L A D+K + Y + GK K T V +KTL PV+ E +++ +++
Sbjct: 977 LAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQK- 1035
Query: 79 KYILFLIVMHRSLVGLDKFLGQVAINLND-IFEDKQRRKTEWFRLESKQGK---RIKNRG 134
L L + HR + FLG+V ++L +++KQ ++ W+ L+ K +NRG
Sbjct: 1036 ---LNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 1092
Query: 135 EIKVNIQFM 143
E+K+ +Q++
Sbjct: 1093 EMKLALQYV 1101
>gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens]
Length = 1272
Score = 50.1 bits (118), Expect = 5e-06
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 9/129 (6%)
Query: 20 LQAKDLKPKGKSGTNDTYTIIQLGKE-KYSTSVAEKTLEPVWKEEASFELPGLLIQGSPE 78
L A D+K + Y + GK K T V +KTL PV+ E +++ +++
Sbjct: 993 LAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQK- 1051
Query: 79 KYILFLIVMHRSLVGLDKFLGQVAINLND-IFEDKQRRKTEWFRLESKQGK---RIKNRG 134
L L + HR + FLG+V ++L +++KQ ++ W+ L+ K +NRG
Sbjct: 1052 ---LNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRG 1108
Query: 135 EIKVNIQFM 143
E+K+ +Q++
Sbjct: 1109 EMKLALQYV 1117
>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
Length = 1591
Score = 50.1 bits (118), Expect = 5e-06
Identities = 47/184 (25%), Positives = 79/184 (42%), Gaps = 25/184 (13%)
Query: 9 KWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFEL 68
KW + +TV+ A+ L+ K K+G++D Y +Q+ K K T L PVW+E+ FE
Sbjct: 597 KW-SAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFEC 655
Query: 69 PG----LLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLES 124
+ ++ E + V R D FLGQ I + + + W+ LE
Sbjct: 656 HNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMD----VWYNLEK 711
Query: 125 KQGK-----------RIKNRGEIKV---NIQF--MRNNMTASMFDLSMKDKTRSPFAKLK 168
+ K ++ +GE KV ++Q+ + N+ + D+ R P A+
Sbjct: 712 RTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGD 771
Query: 169 DKMK 172
D K
Sbjct: 772 DAWK 775
Score = 34.3 bits (77), Expect = 0.28
Identities = 29/106 (27%), Positives = 52/106 (49%), Gaps = 9/106 (8%)
Query: 20 LQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQGSPEK 79
++ K K +G +TY +++ K ST+VA + +P W+++ FE+ L + S E
Sbjct: 6 VRVKRAKFQGSPDKFNTYVTLKVQNVK-STTVAVRGDQPSWEQDFMFEISRLDLGLSVE- 63
Query: 80 YILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESK 125
V ++ L+ D +G V I L I + + EW LE++
Sbjct: 64 ------VWNKGLI-WDTMVGTVWIALKTIRQSDEEGPGEWSTLEAE 102
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 49.3 bits (116), Expect = 8e-06
Identities = 49/174 (28%), Positives = 78/174 (44%), Gaps = 32/174 (18%)
Query: 19 VLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASF-ELPGLLIQGSP 77
VL A+DL P+ SGT+D + + G + TS +KT P W E E+PG SP
Sbjct: 139 VLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPG---APSP 195
Query: 78 EKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRL------ESKQGKRIK 131
+ L+ +VG + FLG V + + +Q+ WFRL E G
Sbjct: 196 LRVELW----DWDMVGKNDFLGMVEFSPKTL---QQKPPKGWFRLLPFPRAEEDSG---G 245
Query: 132 NRGEIKVNIQFMRNNMTAS-----MFDLSM-------KDKTRSPFAKLKDKMKG 173
N G ++V ++ + + + S + +L M ++ T SP A L++ G
Sbjct: 246 NLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLG 299
Score = 44.7 bits (104), Expect = 2e-04
Identities = 40/163 (24%), Positives = 77/163 (47%), Gaps = 19/163 (11%)
Query: 15 VQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYS-TSVAEKTLEPVWKEEASFELPGLLI 73
+ V V++ + L K SG++D Y ++++ E + T+ ++L P W EE + LP
Sbjct: 7 LNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLP---- 62
Query: 74 QGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNR 133
+ + L V+ VG D +G+++++ I D R W L S+ + +
Sbjct: 63 ---LDFHQLAFYVLDEDTVGHDDIIGKISLSREAITAD-PRGIDSWINL-SRVDPDAEVQ 117
Query: 134 GEIKVNIQFMRNNMTASM-------FDLSMKD--KTRSPFAKL 167
GEI +++Q + + + DL+ +D T PFA++
Sbjct: 118 GEICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARV 160
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/191 (23%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 17 VTVLQAKDLKPKGKSGTNDTYTIIQL---GKEKYSTSVAEKTLEPVWKEEASFELPGLLI 73
V ++QA +L GT+D Y + L K+K+ T V KTL PV+ E+ +F++P +
Sbjct: 161 VGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSEL 220
Query: 74 QGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNR 133
G L + V +G+ + +N + D EW L+S + + +
Sbjct: 221 GGK----TLVMAVYDFDRFSKHDIIGEFKVPMNTV--DFGHVTEEWRDLQSAEKEEQEKL 274
Query: 134 GEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKD---KMKGRKNDGTFSDTSSAIIPS 190
G+I +++++ ++ L K+ + L D K+ +N + I +
Sbjct: 275 GDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKN 334
Query: 191 THMPDANSEFS 201
T P N FS
Sbjct: 335 TLNPYYNESFS 345
Score = 45.8 bits (107), Expect = 9e-05
Identities = 38/135 (28%), Positives = 66/135 (48%), Gaps = 21/135 (15%)
Query: 9 KWFPTHVQVTV--LQAKDLKPKGKSGTNDTYTIIQL---GK--EKYSTSVAEKTLEPVWK 61
++ PT ++TV L+AK+LK G +D Y I L GK +K T++ + TL P +
Sbjct: 282 RYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYN 341
Query: 62 EEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLN----------DIFED 111
E SFE+P IQ K + + V+ +G + +G+V + N D+ +
Sbjct: 342 ESFSFEVPFEQIQ----KVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLAN 397
Query: 112 KQRRKTEWFRLESKQ 126
+R +W L+ ++
Sbjct: 398 PRRPIAQWHTLQVEE 412
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/191 (23%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 17 VTVLQAKDLKPKGKSGTNDTYTIIQL---GKEKYSTSVAEKTLEPVWKEEASFELPGLLI 73
V ++QA +L GT+D Y + L K+K+ T V KTL PV+ E+ +F++P +
Sbjct: 161 VGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSEL 220
Query: 74 QGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNR 133
G L + V +G+ + +N + D EW L+S + + +
Sbjct: 221 GGK----TLVMAVYDFDRFSKHDIIGEFKVPMNTV--DFGHVTEEWRDLQSAEKEEQEKL 274
Query: 134 GEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKD---KMKGRKNDGTFSDTSSAIIPS 190
G+I +++++ ++ L K+ + L D K+ +N + I +
Sbjct: 275 GDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKN 334
Query: 191 THMPDANSEFS 201
T P N FS
Sbjct: 335 TLNPYYNESFS 345
Score = 45.8 bits (107), Expect = 9e-05
Identities = 38/135 (28%), Positives = 66/135 (48%), Gaps = 21/135 (15%)
Query: 9 KWFPTHVQVTV--LQAKDLKPKGKSGTNDTYTIIQL---GK--EKYSTSVAEKTLEPVWK 61
++ PT ++TV L+AK+LK G +D Y I L GK +K T++ + TL P +
Sbjct: 282 RYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYN 341
Query: 62 EEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLN----------DIFED 111
E SFE+P IQ K + + V+ +G + +G+V + N D+ +
Sbjct: 342 ESFSFEVPFEQIQ----KVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLAN 397
Query: 112 KQRRKTEWFRLESKQ 126
+R +W L+ ++
Sbjct: 398 PRRPIAQWHTLQVEE 412
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/191 (23%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 17 VTVLQAKDLKPKGKSGTNDTYTIIQL---GKEKYSTSVAEKTLEPVWKEEASFELPGLLI 73
V ++QA +L GT+D Y + L K+K+ T V KTL PV+ E+ +F++P +
Sbjct: 161 VGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSEL 220
Query: 74 QGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNR 133
G L + V +G+ + +N + D EW L+S + + +
Sbjct: 221 GGK----TLVMAVYDFDRFSKHDIIGEFKVPMNTV--DFGHVTEEWRDLQSAEKEEQEKL 274
Query: 134 GEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKD---KMKGRKNDGTFSDTSSAIIPS 190
G+I +++++ ++ L K+ + L D K+ +N + I +
Sbjct: 275 GDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKN 334
Query: 191 THMPDANSEFS 201
T P N FS
Sbjct: 335 TLNPYYNESFS 345
Score = 45.8 bits (107), Expect = 9e-05
Identities = 38/135 (28%), Positives = 66/135 (48%), Gaps = 21/135 (15%)
Query: 9 KWFPTHVQVTV--LQAKDLKPKGKSGTNDTYTIIQL---GK--EKYSTSVAEKTLEPVWK 61
++ PT ++TV L+AK+LK G +D Y I L GK +K T++ + TL P +
Sbjct: 282 RYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYN 341
Query: 62 EEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLN----------DIFED 111
E SFE+P IQ K + + V+ +G + +G+V + N D+ +
Sbjct: 342 ESFSFEVPFEQIQ----KVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLAN 397
Query: 112 KQRRKTEWFRLESKQ 126
+R +W L+ ++
Sbjct: 398 PRRPIAQWHTLQVEE 412
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 47.8 bits (112), Expect = 2e-05
Identities = 45/191 (23%), Positives = 80/191 (41%), Gaps = 12/191 (6%)
Query: 17 VTVLQAKDLKPKGKSGTNDTYTIIQL---GKEKYSTSVAEKTLEPVWKEEASFELPGLLI 73
V VLQA +L GT+D Y + L K+KY T V KTL P + E +F++P +
Sbjct: 158 VGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQEL 217
Query: 74 QGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNR 133
G L + + +G+V + +N + D + EW L+ + + +
Sbjct: 218 GGK----TLVMAIYDFDRFSKHDIIGEVKVPMNTV--DLGQPIEEWRDLQGGEKEEPEKL 271
Query: 134 GEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKD---KMKGRKNDGTFSDTSSAIIPS 190
G+I +++++ ++ L K+ + L D K+ +N + +
Sbjct: 272 GDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKK 331
Query: 191 THMPDANSEFS 201
T P N FS
Sbjct: 332 TLNPYFNESFS 342
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/135 (28%), Positives = 68/135 (50%), Gaps = 21/135 (15%)
Query: 9 KWFPTHVQVTV--LQAKDLKPKGKSGTNDTYTIIQL---GK--EKYSTSVAEKTLEPVWK 61
++ PT ++TV L+AK+LK G +D Y I L GK +K T+V +KTL P +
Sbjct: 279 RYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFN 338
Query: 62 EEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLN----------DIFED 111
E SFE+P IQ K + + V+ +G ++ +G++ + N D+ +
Sbjct: 339 ESFSFEIPFEQIQ----KVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLAN 394
Query: 112 KQRRKTEWFRLESKQ 126
+R +W L+ ++
Sbjct: 395 PRRPIAQWHSLKPEE 409
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,178,124
Number of Sequences: 37866
Number of extensions: 869740
Number of successful extensions: 2802
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 2578
Number of HSP's gapped (non-prelim): 271
length of query: 512
length of database: 18,247,518
effective HSP length: 107
effective length of query: 405
effective length of database: 14,195,856
effective search space: 5749321680
effective search space used: 5749321680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.