Search of human proteins with 7662176

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7662176 ProSAPiP1 protein [Homo sapiens]
         (673 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7662176 ProSAPiP1 protein [Homo sapiens]                          1325   0.0  
gi|45331215 leucine zipper, putative tumor suppressor 2 [Homo sa...   323   4e-88
gi|10440566 leucine zipper, putative tumor suppressor 1 [Homo sa...   302   8e-82
gi|62177129 Nedd4 binding protein 3 [Homo sapiens]                    191   2e-48
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                74   4e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        74   4e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        74   4e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         74   4e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         74   4e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         74   4e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         74   4e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         74   4e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         74   4e-13
gi|21735548 centrosomal protein 2 [Homo sapiens]                       70   8e-12
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom...    67   5e-11
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    65   2e-10
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    65   2e-10
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    65   2e-10
gi|57864582 hornerin [Homo sapiens]                                    65   3e-10
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi...    64   3e-10
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    64   5e-10
gi|4506467 radixin [Homo sapiens]                                      63   1e-09
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]            62   1e-09
gi|16262452 cingulin [Homo sapiens]                                    62   1e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    61   3e-09
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    61   4e-09
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]                61   4e-09
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         61   4e-09
gi|4505257 moesin [Homo sapiens]                                       60   5e-09
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       60   5e-09

>gi|7662176 ProSAPiP1 protein [Homo sapiens]
          Length = 673

 Score = 1325 bits (3428), Expect = 0.0
 Identities = 673/673 (100%), Positives = 673/673 (100%)

Query: 1   MAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLAMGSVGSGVAHAQEFAMKSVGTRTG 60
           MAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLAMGSVGSGVAHAQEFAMKSVGTRTG
Sbjct: 1   MAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLAMGSVGSGVAHAQEFAMKSVGTRTG 60

Query: 61  GGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVGSSG 120
           GGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVGSSG
Sbjct: 61  GGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVGSSG 120

Query: 121 GSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCP 180
           GSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCP
Sbjct: 121 GSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCP 180

Query: 181 PQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQHLAP 240
           PQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQHLAP
Sbjct: 181 PQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQHLAP 240

Query: 241 LSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLGSG 300
           LSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLGSG
Sbjct: 241 LSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLGSG 300

Query: 301 EGGGGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAW 360
           EGGGGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAW
Sbjct: 301 EGGGGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAW 360

Query: 361 ERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDK 420
           ERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDK
Sbjct: 361 ERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDK 420

Query: 421 VAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREG 480
           VAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREG
Sbjct: 421 VAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREG 480

Query: 481 RASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDE 540
           RASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDE
Sbjct: 481 RASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDE 540

Query: 541 AKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAE 600
           AKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAE
Sbjct: 541 AKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAE 600

Query: 601 ERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKAW 660
           ERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKAW
Sbjct: 601 ERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKAW 660

Query: 661 TPSRLERIESTEI 673
           TPSRLERIESTEI
Sbjct: 661 TPSRLERIESTEI 673


>gi|45331215 leucine zipper, putative tumor suppressor 2 [Homo
           sapiens]
          Length = 669

 Score =  323 bits (827), Expect = 4e-88
 Identities = 261/702 (37%), Positives = 358/702 (50%), Gaps = 128/702 (18%)

Query: 1   MAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLAMGSVGSGVAHAQEFAMKSVGTRTG 60
           MA ++TLPV  +P   P  A AP+            MGSV S ++          G    
Sbjct: 1   MAIVQTLPVPLEPA--PEAATAPQAP---------VMGSVSSLIS----------GRPCP 39

Query: 61  GGGSQGSFPGPRGS-----------GSGASRER--PGRYPSEDKGLANSLYLNGELRGSD 107
           GG +     GP G            G   ++E   P   P +   + +  Y+N + R   
Sbjct: 40  GGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFR--- 96

Query: 108 HTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSH----PPKLLATSGKLDQCSEP-LVRPS 162
                     +    S S   + A  Q    +H    PPKL+  SGKL++  E  L+RP+
Sbjct: 97  ----------TESPPSPSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPT 146

Query: 163 AFKPVVPK--NFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTP------------ 208
           AFKPV+PK     S+ +   P+  G    +     L GG   S + +             
Sbjct: 147 AFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAFS 206

Query: 209 --AGGSGSG-LSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSG 265
             A G  SG LSDSGRNSL+SLPTYS+  ++     S+   H+      S+GSG G   G
Sbjct: 207 GWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTT--SSPGGHL-----PSHGSGRGALPG 259

Query: 266 GGSGYQDLGT-SDSGRASSKSGSSSSMGRP--GHLGSGEGG-------GGGLPFAACSPP 315
              G     + SDSGR+SS   + S  GR   G LGSG          G   P     PP
Sbjct: 260 PARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPP 319

Query: 316 SPSALIQ-ELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGK 374
           S  AL+   LE +L ++E E+  LR SL+++EA + Q  EERQ+ W+RE   LR+ C+ +
Sbjct: 320 SDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQ 379

Query: 375 LQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPR 434
               A+RAQRAQQ LQLQV +LQQ+K+QLQ++ A+L+++RE+LE + A  ++EQ +  PR
Sbjct: 380 ----AQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPR 435

Query: 435 IEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSL 494
           +EETKWEVCQK+GEISLLKQQLK+SQA++ QK SE+V LR  LRE RA+LR  E +   L
Sbjct: 436 LEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGL 495

Query: 495 RDSFSSKQASLEL-----------------GEGELPAACLKPALTPVDPAEPQDALATCE 537
           +++  +++  LE                    G+L A        PV PA   D     E
Sbjct: 496 QEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPA-TADPFLLAE 554

Query: 538 SDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGAS 597
           SDEAK++R A              A  GG     +LR +V RL+ EL  ERR  E Q  S
Sbjct: 555 SDEAKVQRAA--------------AGVGG-----SLRAQVERLRVELQRERRRGEEQRDS 595

Query: 598 FAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
           F  ER  W  EKE+VI YQKQLQ +Y++MY+RN+QLE+ L++
Sbjct: 596 FEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQ 637



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 36/156 (23%), Positives = 61/156 (39%), Gaps = 6/156 (3%)

Query: 321 IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
           ++   + L    QE   LR    Q +A  A + E        +   L +    K+Q   R
Sbjct: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ---R 562

Query: 381 RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
            A      L+ QV RL   + +LQ E  R   QR+  E +  A Q E+   +   ++ + 
Sbjct: 563 AAAGVGGSLRAQVERL---RVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619

Query: 441 EVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQ 476
              Q       L+Q+L+    ++  +    +GL  Q
Sbjct: 620 NYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQ 655


>gi|10440566 leucine zipper, putative tumor suppressor 1 [Homo
           sapiens]
          Length = 596

 Score =  302 bits (773), Expect = 8e-82
 Identities = 217/582 (37%), Positives = 310/582 (53%), Gaps = 61/582 (10%)

Query: 74  SGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPP 133
           SG G S  + G+  SED      + ++ + RGS H D      G  GG +   G D    
Sbjct: 50  SGHGKSSSKMGK--SEDFFY---IKVSQKARGSHHPDYTALSSGDLGGQA---GVDF--- 98

Query: 134 QYREPSHPPKLLATSGKLDQCSEP-LVRPSAFKPVVPKN---FHSMQNLCPPQTNGTPEG 189
              +PS PPKL+  S +L+  SE   VRP+AFKPV+P++    HS       Q +  P  
Sbjct: 99  ---DPSTPPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPD 155

Query: 190 RQGPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHIN 249
           +     LK GL               LSDSGRNS++SLPT+S+S S  L PL       +
Sbjct: 156 KPKEQELKPGL-----------CSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTS 204

Query: 250 RIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMG-RPGHLGSGEGGGGGLP 308
           R G +++    G           +   DS   S K+ S S  G + GH    + G    P
Sbjct: 205 RFGGSAHNITQG-----------IVLQDSNMMSLKALSFSDGGSKLGHSNKADKG----P 249

Query: 309 FAACSPPSPSAL-IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAEL 367
               SP S     IQELE++L E+E  +  L+RS E+ E A +   EER +    EL   
Sbjct: 250 SCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGP 309

Query: 368 RQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE 427
                 KL+Q ++++QRAQQ L LQVL+LQQ+K+QL++E   LM++++ LE K+ + ++E
Sbjct: 310 EPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYERE 369

Query: 428 QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
           +  F P +EET+WEVCQK+GEISLLKQQLK+SQ +V+ K SEI+GL++QL++ R  L   
Sbjct: 370 KTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGL 429

Query: 488 EEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQA 547
           E +   L  +  +K   LE+ E EL     +  L        ++ +   E +  ++R QA
Sbjct: 430 ELRTQDLEGALRTKGLELEVCENELQRKKNEAELL-------REKVNLLEQELQELRAQA 482

Query: 548 GVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLE 607
            +A      +   +          AL+RE+ RL+AEL  ER+  ++  + F  ER VW E
Sbjct: 483 ALARDMGPPTFPEDVP--------ALQRELERLRAELREERQGHDQMSSGFQHERLVWKE 534

Query: 608 EKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTP 649
           EKEKVI+YQKQLQ SYV MYQRNQ+LE+ L++      A  P
Sbjct: 535 EKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEP 576


>gi|62177129 Nedd4 binding protein 3 [Homo sapiens]
          Length = 544

 Score =  191 bits (484), Expect = 2e-48
 Identities = 199/663 (30%), Positives = 293/663 (44%), Gaps = 142/663 (21%)

Query: 30  PPDPRLAMGSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSE 89
           P    +AMGSVGS +   Q+F+ + +         + +  G RGS       R G    E
Sbjct: 5   PGPAGIAMGSVGS-LLERQDFSPEEL---------RAALAGSRGSRQPDGLLRKGLGQRE 54

Query: 90  DKGLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATS- 148
                   YL+   + S  T        ++  +  +  +D A   YRE S       TS 
Sbjct: 55  FLS-----YLHLPKKDSKSTK-------NTKRAPRNEPADYATLYYREHSRAGDFSKTSL 102

Query: 149 ---GKLDQCSEPLVRPSAFKPVVP--KNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKS 203
              G+ D+C    +RPS FKP     K F SMQ+L                       K 
Sbjct: 103 PERGRFDKCR---IRPSVFKPTAGNGKGFLSMQSLAS--------------------HKG 139

Query: 204 RTMTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGS 263
           + +  + GS   L+      L+  P  S + +Q L  LS     ++  G     S S  S
Sbjct: 140 QKLWRSNGSLHTLAC--HPPLSPGPRASQARAQLLHALS-----LDEGGPEPEPSLSDSS 192

Query: 264 SGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLGSG---------EGGGGGLPFAACSP 314
           SGG  G            +  S  SSS+G   HLG           E G   +      P
Sbjct: 193 SGGSFGRSP--------GTGPSPFSSSLGHLNHLGGSLDRASQGPKEAGPPAVLSCLPEP 244

Query: 315 PSPSALIQELEERLWEKEQEVAA-LRRSL--EQSEAAVAQVLEERQKAWERELAELRQGC 371
           P P        E +     E    L+R L  E       QVLEERQ+ W   LAEL++  
Sbjct: 245 PPPYEFSCSSAEEMGAVLPETCEELKRGLGDEDGSNPFTQVLEERQRLW---LAELKRLY 301

Query: 372 SGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADF 431
             +L +V ++A+R+++ LQLQ+   QQ++++L++E   L  Q+    +  A     +AD 
Sbjct: 302 VERLHEVTQKAERSERNLQLQLFMAQQEQRRLRKE---LRAQQGLAPEPRAPGTLPEADP 358

Query: 432 LPRIEE-TKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQ 490
             R EE  +WEVCQK  EISLLKQQL+++QA+++QKL+EI  L++QLR  RA  + ++ +
Sbjct: 359 SARPEEEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAE 418

Query: 491 LLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVA 550
           L+ LR++  S Q                      + A  ++A  +CE+D+ K R   G  
Sbjct: 419 LVRLREAVRSLQ----------------------EQAPREEAPGSCETDDCKSRGLLG-- 454

Query: 551 AAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKE 610
                       EAGG       R    +L+AEL  ER   + Q   F +ERR W EEKE
Sbjct: 455 ------------EAGGSEA----RDSAEQLRAELLQERLRGQEQALRFEQERRTWQEEKE 498

Query: 611 KVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKAWTPSRLERIES 670
           +V+ YQ+++Q  Y++MY+RNQ LE+ LR          PTP        W+P    R+ES
Sbjct: 499 RVLRYQREIQGGYMDMYRRNQALEQELRAL-----REPPTP--------WSP----RLES 541

Query: 671 TEI 673
           ++I
Sbjct: 542 SKI 544


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 94/333 (28%), Positives = 150/333 (45%), Gaps = 48/333 (14%)

Query: 323  ELEERLWEKEQEVAAL--RRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            +L   + + E+E +AL  R+   + EA VA+  +ER +    E    RQG  G L    R
Sbjct: 754  DLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSL----R 809

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQ-----------REELEDKVAACQ---- 425
             A++AQ+ L+ Q+  L+ ++ QLQE+ A+L RQ           R E + +V A +    
Sbjct: 810  VAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAR 869

Query: 426  ------KEQADFLPRIEETKWE---VCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQ 476
                  KE A    ++   + E   + ++A  + L K+ L+ S  +V ++L+++   R Q
Sbjct: 870  EKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQ 929

Query: 477  LR-EGRASLREKEE---QLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDA 532
            L  EG+A L  KE    +L  LR    + Q    L + EL A  L  A      A  ++ 
Sbjct: 930  LEAEGQALLLAKETLTGELAGLRQQIIATQEKASL-DKELMAQKLVQAEREAQ-ASLREQ 987

Query: 533  LATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARE 592
             A  E D  +++R+   A          E EA        L+RE   L A L AE+    
Sbjct: 988  RAAHEEDLQRLQREKEAAWR--------ELEAERAQLQSQLQREQEELLARLEAEKEELS 1039

Query: 593  RQGASFAEERRVWLEEKEKVIEYQKQLQLSYVE 625
             + A+  +ER    +E   + E +KQ  LS  E
Sbjct: 1040 EEIAALQQER----DEGLLLAESEKQQALSLKE 1068



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 100/411 (24%), Positives = 172/411 (41%), Gaps = 43/411 (10%)

Query: 280  RASSKSGSSSSMGRPGHLGSGEGGGGGLPFAACSPPSPS-----------ALIQELEERL 328
            R +   GS   +  P  L    G     P  A SP SP              +QEL    
Sbjct: 1463 RDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQ 1522

Query: 329  WEKEQ---EVAALRRSLEQSEA---AVAQVLEERQKAWERELAELRQGCSGKLQQVARRA 382
             E+++   + +AL R L + EA   +      + QKA   E  E R+   G+L  V  +A
Sbjct: 1523 RERDELRTQTSALNRQLAEMEAERDSATSRARQLQKA-VAESEEARRSVDGRLSGV--QA 1579

Query: 383  QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEV 442
            + A Q  +  V R +++++   ++ A L R  +  E ++ A Q++ +    +  ETK E 
Sbjct: 1580 ELALQ--EESVRRSERERRATLDQVATLERSLQATESELRASQEKISKM--KANETKLE- 1634

Query: 443  CQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQ 502
                G+   LK+ L  S++   +   +   L  +L+  R  L ++E Q  +L+D   S Q
Sbjct: 1635 ----GDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQ 1690

Query: 503  ASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMR---RQAGVAAAASLVSVD 559
               ++ + E+ A  L+  +  ++      ALA  E  E  +R   R    A A S  S++
Sbjct: 1691 R--QVADSEVKAGTLQLTVERLN-----GALAKVEESEGALRDKVRGLTEALAQSSASLN 1743

Query: 560  GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQ-KQ 618
               +            E  R   ++  ER    RQ  S A ++   L E+ + +  +   
Sbjct: 1744 STRDKNLHLQKALTACEHDR---QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVAD 1800

Query: 619  LQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKAWTPSRLERIE 669
            L+L  VE   + QQL   LR+R     A+  T Q  ++++     RL  ++
Sbjct: 1801 LELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQ 1851



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 79/315 (25%), Positives = 139/315 (44%), Gaps = 38/315 (12%)

Query: 333  QEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQ 392
            Q++ A +      +  +AQ L + ++  +  L E R      LQ++ R  + A + L+ +
Sbjct: 953  QQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAE 1012

Query: 393  VLRLQQDKKQLQEEA-ARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQ------- 444
              +LQ   ++ QEE  ARL  ++EEL +++AA Q+E+ + L   E  K +          
Sbjct: 1013 RAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKT 1072

Query: 445  -----------KAGEISL-LKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLL 492
                           ISL +++Q +D+Q+   Q  S +  L S+LR+ RA  + +E    
Sbjct: 1073 ALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA--QREEAAAA 1130

Query: 493  SLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAA 552
              ++    ++ + +LG+     +CL+ A       E +  L   E     +RR+   A  
Sbjct: 1131 HAQEVRRLQEQARDLGKQR--DSCLREA------EELRTQLRLLEDARDGLRRELLEAQR 1182

Query: 553  ASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARE--RQGASFAEERRVWLEEKE 610
                S +G      E+G   LRR +G    E  A RR+ E  R     AE  R+ L    
Sbjct: 1183 KLRESQEGREVQRQEAG--ELRRSLGEGAKEREALRRSNEELRSAVKKAESERISL---- 1236

Query: 611  KVIEYQKQLQLSYVE 625
            K+    K+ +L+ +E
Sbjct: 1237 KLANEDKEQKLALLE 1251



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 104/443 (23%), Positives = 169/443 (38%), Gaps = 72/443 (16%)

Query: 239 APLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLG 298
           A LS S S +   G+      S GS  G SG +    S   R+S   G S   G      
Sbjct: 459 AVLSDSESGVQLSGSERTADASNGSLRGLSGQRT--PSPPRRSSPGRGRSPRRG------ 510

Query: 299 SGEGGGGGLPFAACSPPSPSALI-----------QELEERLWEKEQEVAALRRSLEQSEA 347
                    P  ACS  S  ALI           Q++  R    +  +  LR+ L  SE+
Sbjct: 511 ---------PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSES 561

Query: 348 AVAQVLEERQKAWERELAELRQGCSGKLQ---QVARRAQRAQ-----------------Q 387
                    ++A E +L  LR    G +Q      R  QR +                 Q
Sbjct: 562 --------ERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQ 613

Query: 388 GLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAG 447
             Q Q   L+Q++++LQ     L RQR+ LE++     ++ A     +E +  ++ Q  G
Sbjct: 614 VAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEG 673

Query: 448 EISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLEL 507
           + S+L ++L     +V + LS     R  L+  +A + E   +  + R         L  
Sbjct: 674 KRSVLAKEL----VEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRA 729

Query: 508 GEGELPAACLKPALTPVDPAEPQDAL----ATCESDEAKMRRQAGVAAAASLVSVDGEAE 563
            E  L  +  K  L+ ++ +  QD L       + +E K   Q     A    +V  E +
Sbjct: 730 EEASLQDSLSK--LSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQ 787

Query: 564 AGGESGTRALRREVGR--LQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQL 621
              E     L +EV R  L+  L    +A+E         R    + +E++ +  +QL  
Sbjct: 788 ERLEE--LRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845

Query: 622 SYVEMYQRNQQLERRLR--ERGA 642
              E+ Q  ++ +R++   ER A
Sbjct: 846 REQELEQARREAQRQVEALERAA 868



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 83/324 (25%), Positives = 133/324 (41%), Gaps = 49/324 (15%)

Query: 318  SALIQELEERLWEKEQEVAA----LRRSLEQSEAAVAQVLEERQKAWE-----RELAELR 368
            +AL  EL +   ++E+  AA    +RR  EQ+     Q     ++A E     R L + R
Sbjct: 1111 NALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDAR 1170

Query: 369  QGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQE---EAARLMRQREELEDKVAACQ 425
             G   +L +  R+ + +Q+G ++Q     + ++ L E   E   L R  EEL   V   +
Sbjct: 1171 DGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAE 1230

Query: 426  KEQADF----------LPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEI----- 470
             E+             L  +EE +  V ++AGE+    Q+++ S+ +  ++L E+     
Sbjct: 1231 SERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290

Query: 471  -------------VGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACL 517
                           L+ +L  G  + +E   + L LR      +ASLE+   EL  A  
Sbjct: 1291 MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR 1350

Query: 518  KPALTPVD-PAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRRE 576
            K      +     +  L + E      ++Q   A    L      AEA  E G R    E
Sbjct: 1351 KLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEA-AELGLRLSAAE 1409

Query: 577  VGR---LQAELA---AERRARERQ 594
             GR   L+AELA    +RRA E Q
Sbjct: 1410 -GRAQGLEAELARVEVQRRAAEAQ 1432



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 72/330 (21%), Positives = 135/330 (40%), Gaps = 15/330 (4%)

Query: 323  ELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRA 382
            EL+ R  E E + + L  S  +++A   Q L++R  + +R++A+  +  +G LQ    R 
Sbjct: 1655 ELQRRSLEGELQRSRLGLSDREAQA---QALQDRVDSLQRQVAD-SEVKAGTLQLTVERL 1710

Query: 383  QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDK-------VAACQKEQADFLPRI 435
              A   ++     L+   + L E  A+         DK       + AC+ ++     R+
Sbjct: 1711 NGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL 1770

Query: 436  EETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLR 495
            +  +  + +   + S L +Q++  + +V+    + V    QL++ R  LR+++E   +  
Sbjct: 1771 DAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAAL 1830

Query: 496  DSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASL 555
            ++    Q    L +  L +     A    +  E + +    E D   +RR         L
Sbjct: 1831 NTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKL 1890

Query: 556  VSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEY 615
             S +       E G   L R +   + ELA  +R  ++  A      +     + +V   
Sbjct: 1891 RSHEDTVRLSAEKG--RLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQ 1948

Query: 616  QKQLQLSY-VEMYQRNQ-QLERRLRERGAA 643
            Q+QL+L   VE  +  Q Q ER L  R  A
Sbjct: 1949 QQQLELQQEVERLRSAQAQTERTLEARERA 1978



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 61/234 (26%), Positives = 97/234 (41%), Gaps = 44/234 (18%)

Query: 314 PPSPSALIQELEERLWEKEQEVAALRRSLEQSEA----------AVAQVLEE-------- 355
           P +  A +  L+E     +QE++ +   L QS A          AV++ LE+        
Sbjct: 69  PATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGE 128

Query: 356 ----RQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQ---VLRLQ----QDKKQLQ 404
                 +   R+  ELR+    +     R+ Q  Q+G Q Q   V RLQ    Q KK+  
Sbjct: 129 LETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCS 188

Query: 405 EEAARLMRQREELEDKVAACQKEQADF---LPRIEETKWEVCQKAGEISLLKQQLKDSQA 461
           E   +L+ +  ELE +     +   D    L R+EE +      A   ++L++QL D   
Sbjct: 189 ELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQL-DQAG 247

Query: 462 DVSQKLSEIV--------GLRSQLREGRASLREKEEQLLSLRDSFSSKQASLEL 507
             +Q LSE +          R +L    A+ R +EE   S    FS++ + L L
Sbjct: 248 SANQALSEDIRKVTNDWTRCRKELEHREAAWRREEE---SFNAYFSNEHSRLLL 298



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 57/212 (26%), Positives = 92/212 (43%), Gaps = 55/212 (25%)

Query: 322 QELEER--LWEKEQEVAALRRSLEQSEAAVA--------QVLEERQKAWERELAELRQGC 371
           +ELE R   W +E+E      S E S   +         +++ E +   ER+L +L    
Sbjct: 269 KELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQL---- 324

Query: 372 SGKLQQVARRAQRAQQGLQLQVLRLQQDKKQ--LQEEAARLMRQREELEDKVAACQKEQA 429
            G+L + +R  Q A  GL    LRL + + +  L+++A    +  E+L DKV        
Sbjct: 325 GGELARTSRAVQEAGLGLSTG-LRLAESRAEAALEKQALLQAQLEEQLRDKVLR------ 377

Query: 430 DFLPRIEETKWEVCQKAGEISLLKQQLKDS--QADVSQKLSEIVGLRSQLREGR------ 481
                             E  L +QQ++    +AD+S +++E+ GL  +  E +      
Sbjct: 378 ------------------EKDLAQQQMQSDLDKADLSARVTEL-GLAVKRLEKQNLEKDQ 418

Query: 482 --ASLREKEEQLLSLRDSFSSKQASLELGEGE 511
               L EK E L SLR     +QA+LE  +GE
Sbjct: 419 VNKDLTEKLEALESLR---LQEQAALETEDGE 447



 Score = 34.7 bits (78), Expect = 0.29
 Identities = 41/156 (26%), Positives = 72/156 (46%), Gaps = 21/156 (13%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARR 381
            +E+E      E++  ALRR+L++ E    +  E+  +    E   L +  +G   ++A  
Sbjct: 1862 REVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRL-SAEKGRLDRTLTGAELELAE- 1919

Query: 382  AQRAQQGLQLQVLRL-------------QQDKKQLQEEAARLMRQREELEDKVAACQKEQ 428
            AQR  Q L+ QV+ L             QQ + +LQ+E  RL   + + E  + A ++  
Sbjct: 1920 AQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAH 1979

Query: 429  ADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVS 464
               +  +EE   +V    G+   L+Q+L+ S A  S
Sbjct: 1980 RQRVRGLEE---QVSTLKGQ---LQQELRRSSAPFS 2009



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 7/70 (10%)

Query: 316  SPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCS--- 372
            SP+ L  + +++  E +QEV  LR +  Q+E    + LE R++A  + +  L +  S   
Sbjct: 1939 SPAQLEVDAQQQQLELQQEVERLRSAQAQTE----RTLEARERAHRQRVRGLEEQVSTLK 1994

Query: 373  GKLQQVARRA 382
            G+LQQ  RR+
Sbjct: 1995 GQLQQELRRS 2004


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 99/350 (28%), Positives = 150/350 (42%), Gaps = 55/350 (15%)

Query: 338  LRRSLEQSEAAVAQVLEERQKAWERELA-----ELRQGCSGKLQQVARRAQRAQQGLQLQ 392
            LRR  E+   A  Q  EER++  E E A     +L +  +    Q  R A+  QQ +Q +
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400

Query: 393  VLR-------LQQDKKQLQEEAARLMRQREELEDKVAACQKEQAD-FLPRIEETKWEVCQ 444
            V+R        QQ K+ +QEE  +L RQ  E E +  A Q E A+    RIEE       
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEE------- 1452

Query: 445  KAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLR-----DSFS 499
               EI +++ QL+ ++        E+  LR++  E  A  R+ +E+   LR     +S  
Sbjct: 1453 ---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 500  SKQASLELG---EGELPAACLKP-ALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASL 555
             +QA +EL    + E  AA  K  AL  ++    Q   A     +A++ R   V  A   
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 556  VSVDGEAEAGGESGT---------RALRRE-VGRLQAELAAERRARERQGASFAEE---- 601
                 EAE   +  +         R+L+ E V   Q    AERRA+++  A  A E    
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 602  --RRVWLEEKE------KVIEYQKQLQLSYVEMYQRNQQLERRLRERGAA 643
               R  L+  E      +  E  +Q  L+  E  ++ ++ ER  R RG A
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 93/382 (24%), Positives = 171/382 (44%), Gaps = 59/382 (15%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQV-------------LEERQKAWERELAELR 368
            Q LEE L   ++E AA  +  ++ EA +A+V              EE  ++   +  +  
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789

Query: 369  QGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREE-LEDKVAACQ-- 425
            +  +G+ +++A  A R    L+      ++ ++  +E+AAR   + E  L +K+AA    
Sbjct: 1790 EAEAGRFRELAEEAAR----LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845

Query: 426  ---KEQADFLPRIEETKWEVCQKAGEISL-----LKQQLKDSQADVSQKL--------SE 469
               K +A+   + +E + E  ++  E        L++Q    +AD+ ++L        SE
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905

Query: 470  IVGLRSQLREGRASLREKEEQLLSLRDSF---SSKQASLELGEGELPAACLKPALTPVDP 526
            +   +  + +     R+ EE++L+L+ SF   ++ +A LEL  G + +   +  L   + 
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA-EDTLRSKEQ 1964

Query: 527  AEPQDALAT-CESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELA 585
            AE + A      ++E + RR+A      SL +   E EA  +   +A   EV RL+A++ 
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAA---EEEAARQR--KAALEEVERLKAKVE 2019

Query: 586  AERRARER---------QGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERR 636
              RR RER         Q A  A ++R+  EEK      Q++ Q    E+ Q  QQ +  
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ----ELQQTLQQEQSV 2075

Query: 637  LRERGAAGGASTPTPQHGEEKK 658
            L +      A+    +  EE +
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEAR 2097



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 84/370 (22%), Positives = 161/370 (43%), Gaps = 33/370 (8%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGC--SGKLQQVA 379
            QEL++ L +++  +  LR   E +  A  +  E R +A ERE A+ R+    + +L+Q A
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA-EREAAQSRRQVEEAERLKQSA 2121

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
                +A+   Q    +L   +K+ ++EAAR  +  +    +  A   E        E+T 
Sbjct: 2122 EEQAQARAQAQAAAEKL---RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 440  WEVCQKAGEISLLKQQLKDSQAD----------VSQKLSEIVGLRSQLREGRASLREKEE 489
             +  Q   E++ L+ QL+++             +  + +E    RSQ+ E   S+R + E
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238

Query: 490  QLLSLRDSFSSKQASLELGEGELPAACLKPALTPV-DPAEPQDALATCESDEAKMRRQA- 547
            +L  L+    ++  +L L + +     L+     +   AE    L+    + A++R+ A 
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298

Query: 548  -GVAAAASLVS--VDGEAEAGGESGTRALRREVGRLQAELAAERRAR-----ERQGASFA 599
              +A   +L    +  + +A  E+       E+ + Q ELA E+  R     E+     A
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            EE + +    ++ +E ++Q QL   EM    ++L+ R+ E   A   +    Q   ++  
Sbjct: 2359 EETQGF----QRTLEAERQRQL---EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 660  WTPSRLERIE 669
                +L R E
Sbjct: 2412 EIGEKLHRTE 2421



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 91/369 (24%), Positives = 153/369 (41%), Gaps = 47/369 (12%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            +Q LEE   + E+    LR++  +    V   LE  Q++ E EL   R   + K  Q+ R
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLP---RIEE 437
              Q       + V +L+++ ++  ++ A   R REE E ++   Q +  + L    + EE
Sbjct: 1595 SLQEEH----VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650

Query: 438  TKWEVCQKAGEISLLKQQLK---------DSQADVSQKLSE-IVGLRSQLREGRASLR-E 486
               +      E    K++ +         + QA   ++L+E  +  + QL EG A  R  
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710

Query: 487  KEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
             E++L+ LR      +   +L E EL       A    + A         E++ AK+R +
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEEL-------ARLQREAAAATQKRQELEAELAKVRAE 1763

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWL 606
              V   AS    + E+ +  E   + L  E GR +    AE  AR R   + AEE +   
Sbjct: 1764 MEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRE--LAEEAARLR---ALAEEAK--- 1814

Query: 607  EEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGE---EKKAWTPS 663
                      +Q QL+  +  ++  + ER L E+ AA G +T      E   ++K     
Sbjct: 1815 ----------RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864

Query: 664  RLERIESTE 672
            RL R+   E
Sbjct: 1865 RLRRLAEDE 1873



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 55/370 (14%)

Query: 322  QELEERLWEKEQEVAALRRS----LEQSEAAVAQVLEERQKAWE---RELAELRQGCS-- 372
            + L++R  E++ EV   R      LE+ +A +AQ  + RQ+  E   R+L   R+     
Sbjct: 1161 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1219

Query: 373  GKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFL 432
            G   Q ARR Q   Q + L     Q  ++QL++E A L+ + E   +KV  CQ+    ++
Sbjct: 1220 GAWLQDARRRQEQIQAMPLA--DSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYI 1276

Query: 433  PRIEETKWEVCQKAGEISLLKQQLK------------DSQADVSQKLSEIVGLRSQ-LRE 479
              I++ + ++     ++  +    K                D+    SE+  L SQ ++ 
Sbjct: 1277 NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1336

Query: 480  GRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESD 539
               +LR  EE+     +  + +Q + E        A L+      +      A A  E+ 
Sbjct: 1337 ISETLRRMEEE-----ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391

Query: 540  EAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFA 599
            E + R Q  V           EA    +   R+++ E+ +L+    AE +A+ RQ A  A
Sbjct: 1392 ELQQRMQEEVVRRE-------EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAA 1443

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            E  R+ +EE+ +V+                  QLE   R+RG A G         EE +A
Sbjct: 1444 ERSRLRIEEEIRVVRL----------------QLEATERQRGGAEGELQALRARAEEAEA 1487

Query: 660  WTPSRLERIE 669
                  E  E
Sbjct: 1488 QKRQAQEEAE 1497



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 87/393 (22%), Positives = 157/393 (39%), Gaps = 44/393 (11%)

Query: 322  QELEERLWEKEQEVA--ALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQ-QV 378
            +E  ER  E+ Q  A  ALR  L+  E A  + L + +   ++E AE      GK + Q 
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683

Query: 379  ARRAQRAQQGLQLQV----------LRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQ 428
             R+ + A+Q L+ Q           L  +Q+  +L+ E  +  +QR+ LE+++A  Q+E 
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743

Query: 429  ADFLPRIEETKWEVCQKAGEISLL-------KQQLKDSQADVSQKLSEIVGLRSQLREGR 481
            A    + +E + E+ +   E+ +L       +++ + +     Q+L    G   +L E  
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803

Query: 482  ASLR------EKEEQLLSLRDSFSSKQASLELGE-----GELPAACLKPALTPVDPAEPQ 530
            A LR      +++ QL     +    +A   L E     GE      +  +   +     
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863

Query: 531  DALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA 590
            + L     DEA  RR+    AA     ++       ++    L R+ G ++  L   R+ 
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923

Query: 591  RER---QGASF----AEERRVWLE------EKEKVIEYQKQLQLSYVEMYQRNQQLERRL 637
             E      ASF    A +  + LE        E  +  ++Q +L      Q   + ERR 
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983

Query: 638  RERGAAGGASTPTPQHGEEKKAWTPSRLERIES 670
            RE       S    +    ++      +ER+++
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 51/347 (14%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAE--LRQGCSG----- 373
            +QE  E++ +  +E A L  S+   EAA  + L E   A +R LAE  L++         
Sbjct: 2266 LQEEAEKMKQVAEEAARL--SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323

Query: 374  KLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAR------------------LMRQRE 415
            +L+  A   Q+ ++  Q Q  RLQ+DK+Q+ ++ A                   +  + E
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383

Query: 416  ELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGL-- 473
             L+ +VA   + QA    R EE      ++A EI    ++L  ++    +K++ +  L  
Sbjct: 2384 RLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEI 2436

Query: 474  -RSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDA 532
             R Q       LRE   +L   ++    +   L+L   E+     +  L      + Q  
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSF 2495

Query: 533  LATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARE 592
            L+  E D    R +      A L  +  +  A  +     LR E  R Q ++  ER   +
Sbjct: 2496 LS--EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ----LREEQQRQQQQMEQER---Q 2546

Query: 593  RQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
            R  AS  E RR   E +E V   Q++LQ    ++ Q+ +Q E  L E
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAE 2589



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 79/340 (23%), Positives = 143/340 (42%), Gaps = 36/340 (10%)

Query: 322  QELEERLWEK---EQEVAALRR-SLEQSEAAVAQV-----LEERQKAWERELAELRQGCS 372
            +E EER+ +    E+E A  R+ +LE+ E   A+V     L ER +       +L Q  +
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043

Query: 373  GKLQQVARRA-----QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE 427
             K  Q   +A     Q+ +Q LQ  + + Q    QL+ EA    R  EE E+     ++E
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103

Query: 428  QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
             A    ++EE +  + Q A E +  + Q + +   + ++  +    R+Q  +  A+LR+K
Sbjct: 2104 AAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ--AALRQK 2160

Query: 488  EEQLLSL-RDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
            +     + +    ++Q   +  + E     L+  L      E  D       +E +  + 
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL------EETDHQKNLLDEELQRLKA 2214

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA---RERQGAS-FAEER 602
                AA     V+ E         R    E+ +L+A + AE RA   R++     F +E 
Sbjct: 2215 EATEAARQRSQVEEEL-----FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2269

Query: 603  RVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGA 642
                E+ ++V E   +L ++  E  +  Q  E  L ++ A
Sbjct: 2270 ---AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2306



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 84/323 (26%), Positives = 128/323 (39%), Gaps = 36/323 (11%)

Query: 320  LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
            L+ E  +RL  +  E A  R  +E+   +V   +EE  K   R  AE R         + 
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR-------ALIL 2256

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
            R     Q+ LQ +  ++    KQ+ EEAARL    +E        +++ A      E+  
Sbjct: 2257 RDKDNTQRFLQEEAEKM----KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312

Query: 440  WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
             E  Q   E + LK     ++A++ Q+  E+        + R    +KE+    L +   
Sbjct: 2313 KEKMQAVQEATRLK-----AEAELLQQQKELA-----QEQARRLQEDKEQMAQQLAEETQ 2362

Query: 500  SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
              Q +LE           +     +  AE   A A  E D  + R+QA          + 
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE----KLH 2418

Query: 560  GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
                A  E  T     E+ R Q++  AE R RE    + AE  R    EKEK+ +  K L
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAE-RLRE----AIAELER----EKEKLQQEAKLL 2469

Query: 620  QLSYVEMYQRNQQLERRLRERGA 642
            QL   EM  +  Q E+ L+E  A
Sbjct: 2470 QLKSEEM--QTVQQEQLLQETQA 2490



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 12/172 (6%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            I ELE    + +QE   L+   E+ +    + L +  +A ++     +     + + + +
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
               + +Q  Q +V + Q    QL+EE  R  +Q E+   ++ A  +E      R  E + 
Sbjct: 2512 EKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEAR---RRQHEAEE 2564

Query: 441  EVCQKAGEISLLKQQLKDSQ---ADVSQKLSEIVGLRSQLREGRASLREKEE 489
             V +K  E+  L+QQ +  +   A+ +Q+L E + L  +  + RA+L   EE
Sbjct: 2565 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE--QHRAALAHSEE 2614



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 22/116 (18%)

Query: 332  EQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGL-- 389
            EQE A L + L Q E A AQ L E Q+  ++++ + RQ     +++  RR   A++G+  
Sbjct: 2510 EQEKAKLEQ-LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568

Query: 390  ------QLQVLRLQQDK-------------KQLQEEAARLMRQREELEDKVAACQK 426
                  QL+  R QQ++             + L+E+    +   EE+     A  K
Sbjct: 2569 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 99/350 (28%), Positives = 150/350 (42%), Gaps = 55/350 (15%)

Query: 338  LRRSLEQSEAAVAQVLEERQKAWERELA-----ELRQGCSGKLQQVARRAQRAQQGLQLQ 392
            LRR  E+   A  Q  EER++  E E A     +L +  +    Q  R A+  QQ +Q +
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1404

Query: 393  VLR-------LQQDKKQLQEEAARLMRQREELEDKVAACQKEQAD-FLPRIEETKWEVCQ 444
            V+R        QQ K+ +QEE  +L RQ  E E +  A Q E A+    RIEE       
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEE------- 1456

Query: 445  KAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLR-----DSFS 499
               EI +++ QL+ ++        E+  LR++  E  A  R+ +E+   LR     +S  
Sbjct: 1457 ---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513

Query: 500  SKQASLELG---EGELPAACLKP-ALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASL 555
             +QA +EL    + E  AA  K  AL  ++    Q   A     +A++ R   V  A   
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1573

Query: 556  VSVDGEAEAGGESGT---------RALRRE-VGRLQAELAAERRARERQGASFAEE---- 601
                 EAE   +  +         R+L+ E V   Q    AERRA+++  A  A E    
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633

Query: 602  --RRVWLEEKE------KVIEYQKQLQLSYVEMYQRNQQLERRLRERGAA 643
               R  L+  E      +  E  +Q  L+  E  ++ ++ ER  R RG A
Sbjct: 1634 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1683



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 93/382 (24%), Positives = 171/382 (44%), Gaps = 59/382 (15%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQV-------------LEERQKAWERELAELR 368
            Q LEE L   ++E AA  +  ++ EA +A+V              EE  ++   +  +  
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1793

Query: 369  QGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREE-LEDKVAACQ-- 425
            +  +G+ +++A  A R    L+      ++ ++  +E+AAR   + E  L +K+AA    
Sbjct: 1794 EAEAGRFRELAEEAAR----LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1849

Query: 426  ---KEQADFLPRIEETKWEVCQKAGEISL-----LKQQLKDSQADVSQKL--------SE 469
               K +A+   + +E + E  ++  E        L++Q    +AD+ ++L        SE
Sbjct: 1850 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1909

Query: 470  IVGLRSQLREGRASLREKEEQLLSLRDSF---SSKQASLELGEGELPAACLKPALTPVDP 526
            +   +  + +     R+ EE++L+L+ SF   ++ +A LEL  G + +   +  L   + 
Sbjct: 1910 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA-EDTLRSKEQ 1968

Query: 527  AEPQDALAT-CESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELA 585
            AE + A      ++E + RR+A      SL +   E EA  +   +A   EV RL+A++ 
Sbjct: 1969 AELEAARQRQLAAEEERRRREAEERVQKSLAA---EEEAARQR--KAALEEVERLKAKVE 2023

Query: 586  AERRARER---------QGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERR 636
              RR RER         Q A  A ++R+  EEK      Q++ Q    E+ Q  QQ +  
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ----ELQQTLQQEQSV 2079

Query: 637  LRERGAAGGASTPTPQHGEEKK 658
            L +      A+    +  EE +
Sbjct: 2080 LDQLRGEAEAARRAAEEAEEAR 2101



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 84/370 (22%), Positives = 161/370 (43%), Gaps = 33/370 (8%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGC--SGKLQQVA 379
            QEL++ L +++  +  LR   E +  A  +  E R +A ERE A+ R+    + +L+Q A
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA-EREAAQSRRQVEEAERLKQSA 2125

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
                +A+   Q    +L   +K+ ++EAAR  +  +    +  A   E        E+T 
Sbjct: 2126 EEQAQARAQAQAAAEKL---RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182

Query: 440  WEVCQKAGEISLLKQQLKDSQAD----------VSQKLSEIVGLRSQLREGRASLREKEE 489
             +  Q   E++ L+ QL+++             +  + +E    RSQ+ E   S+R + E
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242

Query: 490  QLLSLRDSFSSKQASLELGEGELPAACLKPALTPV-DPAEPQDALATCESDEAKMRRQA- 547
            +L  L+    ++  +L L + +     L+     +   AE    L+    + A++R+ A 
Sbjct: 2243 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2302

Query: 548  -GVAAAASLVS--VDGEAEAGGESGTRALRREVGRLQAELAAERRAR-----ERQGASFA 599
              +A   +L    +  + +A  E+       E+ + Q ELA E+  R     E+     A
Sbjct: 2303 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2362

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            EE + +    ++ +E ++Q QL   EM    ++L+ R+ E   A   +    Q   ++  
Sbjct: 2363 EETQGF----QRTLEAERQRQL---EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2415

Query: 660  WTPSRLERIE 669
                +L R E
Sbjct: 2416 EIGEKLHRTE 2425



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 91/369 (24%), Positives = 153/369 (41%), Gaps = 47/369 (12%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            +Q LEE   + E+    LR++  +    V   LE  Q++ E EL   R   + K  Q+ R
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1598

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLP---RIEE 437
              Q       + V +L+++ ++  ++ A   R REE E ++   Q +  + L    + EE
Sbjct: 1599 SLQEEH----VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1654

Query: 438  TKWEVCQKAGEISLLKQQLK---------DSQADVSQKLSE-IVGLRSQLREGRASLR-E 486
               +      E    K++ +         + QA   ++L+E  +  + QL EG A  R  
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1714

Query: 487  KEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
             E++L+ LR      +   +L E EL       A    + A         E++ AK+R +
Sbjct: 1715 AEQELIRLRAETEQGEQQRQLLEEEL-------ARLQREAAAATQKRQELEAELAKVRAE 1767

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWL 606
              V   AS    + E+ +  E   + L  E GR +    AE  AR R   + AEE +   
Sbjct: 1768 MEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRE--LAEEAARLR---ALAEEAK--- 1818

Query: 607  EEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGE---EKKAWTPS 663
                      +Q QL+  +  ++  + ER L E+ AA G +T      E   ++K     
Sbjct: 1819 ----------RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1868

Query: 664  RLERIESTE 672
            RL R+   E
Sbjct: 1869 RLRRLAEDE 1877



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 55/370 (14%)

Query: 322  QELEERLWEKEQEVAALRRS----LEQSEAAVAQVLEERQKAWE---RELAELRQGCS-- 372
            + L++R  E++ EV   R      LE+ +A +AQ  + RQ+  E   R+L   R+     
Sbjct: 1165 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1223

Query: 373  GKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFL 432
            G   Q ARR Q   Q + L     Q  ++QL++E A L+ + E   +KV  CQ+    ++
Sbjct: 1224 GAWLQDARRRQEQIQAMPLA--DSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYI 1280

Query: 433  PRIEETKWEVCQKAGEISLLKQQLK------------DSQADVSQKLSEIVGLRSQ-LRE 479
              I++ + ++     ++  +    K                D+    SE+  L SQ ++ 
Sbjct: 1281 NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1340

Query: 480  GRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESD 539
               +LR  EE+     +  + +Q + E        A L+      +      A A  E+ 
Sbjct: 1341 ISETLRRMEEE-----ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1395

Query: 540  EAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFA 599
            E + R Q  V           EA    +   R+++ E+ +L+    AE +A+ RQ A  A
Sbjct: 1396 ELQQRMQEEVVRRE-------EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAA 1447

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            E  R+ +EE+ +V+                  QLE   R+RG A G         EE +A
Sbjct: 1448 ERSRLRIEEEIRVVRL----------------QLEATERQRGGAEGELQALRARAEEAEA 1491

Query: 660  WTPSRLERIE 669
                  E  E
Sbjct: 1492 QKRQAQEEAE 1501



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 87/393 (22%), Positives = 157/393 (39%), Gaps = 44/393 (11%)

Query: 322  QELEERLWEKEQEVA--ALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQ-QV 378
            +E  ER  E+ Q  A  ALR  L+  E A  + L + +   ++E AE      GK + Q 
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687

Query: 379  ARRAQRAQQGLQLQV----------LRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQ 428
             R+ + A+Q L+ Q           L  +Q+  +L+ E  +  +QR+ LE+++A  Q+E 
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747

Query: 429  ADFLPRIEETKWEVCQKAGEISLL-------KQQLKDSQADVSQKLSEIVGLRSQLREGR 481
            A    + +E + E+ +   E+ +L       +++ + +     Q+L    G   +L E  
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807

Query: 482  ASLR------EKEEQLLSLRDSFSSKQASLELGE-----GELPAACLKPALTPVDPAEPQ 530
            A LR      +++ QL     +    +A   L E     GE      +  +   +     
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867

Query: 531  DALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA 590
            + L     DEA  RR+    AA     ++       ++    L R+ G ++  L   R+ 
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1927

Query: 591  RER---QGASF----AEERRVWLE------EKEKVIEYQKQLQLSYVEMYQRNQQLERRL 637
             E      ASF    A +  + LE        E  +  ++Q +L      Q   + ERR 
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1987

Query: 638  RERGAAGGASTPTPQHGEEKKAWTPSRLERIES 670
            RE       S    +    ++      +ER+++
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKA 2020



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 51/347 (14%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAE--LRQGCSG----- 373
            +QE  E++ +  +E A L  S+   EAA  + L E   A +R LAE  L++         
Sbjct: 2270 LQEEAEKMKQVAEEAARL--SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2327

Query: 374  KLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAR------------------LMRQRE 415
            +L+  A   Q+ ++  Q Q  RLQ+DK+Q+ ++ A                   +  + E
Sbjct: 2328 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2387

Query: 416  ELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGL-- 473
             L+ +VA   + QA    R EE      ++A EI    ++L  ++    +K++ +  L  
Sbjct: 2388 RLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEI 2440

Query: 474  -RSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDA 532
             R Q       LRE   +L   ++    +   L+L   E+     +  L      + Q  
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSF 2499

Query: 533  LATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARE 592
            L+  E D    R +      A L  +  +  A  +     LR E  R Q ++  ER   +
Sbjct: 2500 LS--EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ----LREEQQRQQQQMEQER---Q 2550

Query: 593  RQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
            R  AS  E RR   E +E V   Q++LQ    ++ Q+ +Q E  L E
Sbjct: 2551 RLVASMEEARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAE 2593



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 79/340 (23%), Positives = 143/340 (42%), Gaps = 36/340 (10%)

Query: 322  QELEERLWEK---EQEVAALRR-SLEQSEAAVAQV-----LEERQKAWERELAELRQGCS 372
            +E EER+ +    E+E A  R+ +LE+ E   A+V     L ER +       +L Q  +
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047

Query: 373  GKLQQVARRA-----QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE 427
             K  Q   +A     Q+ +Q LQ  + + Q    QL+ EA    R  EE E+     ++E
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2107

Query: 428  QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
             A    ++EE +  + Q A E +  + Q + +   + ++  +    R+Q  +  A+LR+K
Sbjct: 2108 AAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ--AALRQK 2164

Query: 488  EEQLLSL-RDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
            +     + +    ++Q   +  + E     L+  L      E  D       +E +  + 
Sbjct: 2165 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL------EETDHQKNLLDEELQRLKA 2218

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA---RERQGAS-FAEER 602
                AA     V+ E         R    E+ +L+A + AE RA   R++     F +E 
Sbjct: 2219 EATEAARQRSQVEEEL-----FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2273

Query: 603  RVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGA 642
                E+ ++V E   +L ++  E  +  Q  E  L ++ A
Sbjct: 2274 ---AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2310



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 84/323 (26%), Positives = 128/323 (39%), Gaps = 36/323 (11%)

Query: 320  LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
            L+ E  +RL  +  E A  R  +E+   +V   +EE  K   R  AE R         + 
Sbjct: 2208 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR-------ALIL 2260

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
            R     Q+ LQ +  ++    KQ+ EEAARL    +E        +++ A      E+  
Sbjct: 2261 RDKDNTQRFLQEEAEKM----KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2316

Query: 440  WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
             E  Q   E + LK     ++A++ Q+  E+        + R    +KE+    L +   
Sbjct: 2317 KEKMQAVQEATRLK-----AEAELLQQQKELA-----QEQARRLQEDKEQMAQQLAEETQ 2366

Query: 500  SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
              Q +LE           +     +  AE   A A  E D  + R+QA          + 
Sbjct: 2367 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE----KLH 2422

Query: 560  GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
                A  E  T     E+ R Q++  AE R RE    + AE  R    EKEK+ +  K L
Sbjct: 2423 RTELATQEKVTLVQTLEIQRQQSDHDAE-RLRE----AIAELER----EKEKLQQEAKLL 2473

Query: 620  QLSYVEMYQRNQQLERRLRERGA 642
            QL   EM  +  Q E+ L+E  A
Sbjct: 2474 QLKSEEM--QTVQQEQLLQETQA 2494



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 12/172 (6%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            I ELE    + +QE   L+   E+ +    + L +  +A ++     +     + + + +
Sbjct: 2456 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2515

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
               + +Q  Q +V + Q    QL+EE  R  +Q E+   ++ A  +E      R  E + 
Sbjct: 2516 EKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEAR---RRQHEAEE 2568

Query: 441  EVCQKAGEISLLKQQLKDSQ---ADVSQKLSEIVGLRSQLREGRASLREKEE 489
             V +K  E+  L+QQ +  +   A+ +Q+L E + L  +  + RA+L   EE
Sbjct: 2569 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE--QHRAALAHSEE 2618



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 22/116 (18%)

Query: 332  EQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGL-- 389
            EQE A L + L Q E A AQ L E Q+  ++++ + RQ     +++  RR   A++G+  
Sbjct: 2514 EQEKAKLEQ-LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572

Query: 390  ------QLQVLRLQQDK-------------KQLQEEAARLMRQREELEDKVAACQK 426
                  QL+  R QQ++             + L+E+    +   EE+     A  K
Sbjct: 2573 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2628


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 99/350 (28%), Positives = 150/350 (42%), Gaps = 55/350 (15%)

Query: 338  LRRSLEQSEAAVAQVLEERQKAWERELA-----ELRQGCSGKLQQVARRAQRAQQGLQLQ 392
            LRR  E+   A  Q  EER++  E E A     +L +  +    Q  R A+  QQ +Q +
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400

Query: 393  VLR-------LQQDKKQLQEEAARLMRQREELEDKVAACQKEQAD-FLPRIEETKWEVCQ 444
            V+R        QQ K+ +QEE  +L RQ  E E +  A Q E A+    RIEE       
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEE------- 1452

Query: 445  KAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLR-----DSFS 499
               EI +++ QL+ ++        E+  LR++  E  A  R+ +E+   LR     +S  
Sbjct: 1453 ---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 500  SKQASLELG---EGELPAACLKP-ALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASL 555
             +QA +EL    + E  AA  K  AL  ++    Q   A     +A++ R   V  A   
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 556  VSVDGEAEAGGESGT---------RALRRE-VGRLQAELAAERRARERQGASFAEE---- 601
                 EAE   +  +         R+L+ E V   Q    AERRA+++  A  A E    
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 602  --RRVWLEEKE------KVIEYQKQLQLSYVEMYQRNQQLERRLRERGAA 643
               R  L+  E      +  E  +Q  L+  E  ++ ++ ER  R RG A
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 93/382 (24%), Positives = 171/382 (44%), Gaps = 59/382 (15%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQV-------------LEERQKAWERELAELR 368
            Q LEE L   ++E AA  +  ++ EA +A+V              EE  ++   +  +  
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789

Query: 369  QGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREE-LEDKVAACQ-- 425
            +  +G+ +++A  A R    L+      ++ ++  +E+AAR   + E  L +K+AA    
Sbjct: 1790 EAEAGRFRELAEEAAR----LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845

Query: 426  ---KEQADFLPRIEETKWEVCQKAGEISL-----LKQQLKDSQADVSQKL--------SE 469
               K +A+   + +E + E  ++  E        L++Q    +AD+ ++L        SE
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905

Query: 470  IVGLRSQLREGRASLREKEEQLLSLRDSF---SSKQASLELGEGELPAACLKPALTPVDP 526
            +   +  + +     R+ EE++L+L+ SF   ++ +A LEL  G + +   +  L   + 
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA-EDTLRSKEQ 1964

Query: 527  AEPQDALAT-CESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELA 585
            AE + A      ++E + RR+A      SL +   E EA  +   +A   EV RL+A++ 
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAA---EEEAARQR--KAALEEVERLKAKVE 2019

Query: 586  AERRARER---------QGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERR 636
              RR RER         Q A  A ++R+  EEK      Q++ Q    E+ Q  QQ +  
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ----ELQQTLQQEQSV 2075

Query: 637  LRERGAAGGASTPTPQHGEEKK 658
            L +      A+    +  EE +
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEAR 2097



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 84/370 (22%), Positives = 161/370 (43%), Gaps = 33/370 (8%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGC--SGKLQQVA 379
            QEL++ L +++  +  LR   E +  A  +  E R +A ERE A+ R+    + +L+Q A
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA-EREAAQSRRQVEEAERLKQSA 2121

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
                +A+   Q    +L   +K+ ++EAAR  +  +    +  A   E        E+T 
Sbjct: 2122 EEQAQARAQAQAAAEKL---RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 440  WEVCQKAGEISLLKQQLKDSQAD----------VSQKLSEIVGLRSQLREGRASLREKEE 489
             +  Q   E++ L+ QL+++             +  + +E    RSQ+ E   S+R + E
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238

Query: 490  QLLSLRDSFSSKQASLELGEGELPAACLKPALTPV-DPAEPQDALATCESDEAKMRRQA- 547
            +L  L+    ++  +L L + +     L+     +   AE    L+    + A++R+ A 
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298

Query: 548  -GVAAAASLVS--VDGEAEAGGESGTRALRREVGRLQAELAAERRAR-----ERQGASFA 599
              +A   +L    +  + +A  E+       E+ + Q ELA E+  R     E+     A
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            EE + +    ++ +E ++Q QL   EM    ++L+ R+ E   A   +    Q   ++  
Sbjct: 2359 EETQGF----QRTLEAERQRQL---EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 660  WTPSRLERIE 669
                +L R E
Sbjct: 2412 EIGEKLHRTE 2421



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 91/369 (24%), Positives = 153/369 (41%), Gaps = 47/369 (12%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            +Q LEE   + E+    LR++  +    V   LE  Q++ E EL   R   + K  Q+ R
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLP---RIEE 437
              Q       + V +L+++ ++  ++ A   R REE E ++   Q +  + L    + EE
Sbjct: 1595 SLQEEH----VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650

Query: 438  TKWEVCQKAGEISLLKQQLK---------DSQADVSQKLSE-IVGLRSQLREGRASLR-E 486
               +      E    K++ +         + QA   ++L+E  +  + QL EG A  R  
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710

Query: 487  KEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
             E++L+ LR      +   +L E EL       A    + A         E++ AK+R +
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEEL-------ARLQREAAAATQKRQELEAELAKVRAE 1763

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWL 606
              V   AS    + E+ +  E   + L  E GR +    AE  AR R   + AEE +   
Sbjct: 1764 MEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRE--LAEEAARLR---ALAEEAK--- 1814

Query: 607  EEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGE---EKKAWTPS 663
                      +Q QL+  +  ++  + ER L E+ AA G +T      E   ++K     
Sbjct: 1815 ----------RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864

Query: 664  RLERIESTE 672
            RL R+   E
Sbjct: 1865 RLRRLAEDE 1873



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 55/370 (14%)

Query: 322  QELEERLWEKEQEVAALRRS----LEQSEAAVAQVLEERQKAWE---RELAELRQGCS-- 372
            + L++R  E++ EV   R      LE+ +A +AQ  + RQ+  E   R+L   R+     
Sbjct: 1161 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1219

Query: 373  GKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFL 432
            G   Q ARR Q   Q + L     Q  ++QL++E A L+ + E   +KV  CQ+    ++
Sbjct: 1220 GAWLQDARRRQEQIQAMPLA--DSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYI 1276

Query: 433  PRIEETKWEVCQKAGEISLLKQQLK------------DSQADVSQKLSEIVGLRSQ-LRE 479
              I++ + ++     ++  +    K                D+    SE+  L SQ ++ 
Sbjct: 1277 NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1336

Query: 480  GRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESD 539
               +LR  EE+     +  + +Q + E        A L+      +      A A  E+ 
Sbjct: 1337 ISETLRRMEEE-----ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391

Query: 540  EAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFA 599
            E + R Q  V           EA    +   R+++ E+ +L+    AE +A+ RQ A  A
Sbjct: 1392 ELQQRMQEEVVRRE-------EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAA 1443

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            E  R+ +EE+ +V+                  QLE   R+RG A G         EE +A
Sbjct: 1444 ERSRLRIEEEIRVVRL----------------QLEATERQRGGAEGELQALRARAEEAEA 1487

Query: 660  WTPSRLERIE 669
                  E  E
Sbjct: 1488 QKRQAQEEAE 1497



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 87/393 (22%), Positives = 157/393 (39%), Gaps = 44/393 (11%)

Query: 322  QELEERLWEKEQEVA--ALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQ-QV 378
            +E  ER  E+ Q  A  ALR  L+  E A  + L + +   ++E AE      GK + Q 
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683

Query: 379  ARRAQRAQQGLQLQV----------LRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQ 428
             R+ + A+Q L+ Q           L  +Q+  +L+ E  +  +QR+ LE+++A  Q+E 
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743

Query: 429  ADFLPRIEETKWEVCQKAGEISLL-------KQQLKDSQADVSQKLSEIVGLRSQLREGR 481
            A    + +E + E+ +   E+ +L       +++ + +     Q+L    G   +L E  
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803

Query: 482  ASLR------EKEEQLLSLRDSFSSKQASLELGE-----GELPAACLKPALTPVDPAEPQ 530
            A LR      +++ QL     +    +A   L E     GE      +  +   +     
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863

Query: 531  DALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA 590
            + L     DEA  RR+    AA     ++       ++    L R+ G ++  L   R+ 
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923

Query: 591  RER---QGASF----AEERRVWLE------EKEKVIEYQKQLQLSYVEMYQRNQQLERRL 637
             E      ASF    A +  + LE        E  +  ++Q +L      Q   + ERR 
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983

Query: 638  RERGAAGGASTPTPQHGEEKKAWTPSRLERIES 670
            RE       S    +    ++      +ER+++
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 51/347 (14%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAE--LRQGCSG----- 373
            +QE  E++ +  +E A L  S+   EAA  + L E   A +R LAE  L++         
Sbjct: 2266 LQEEAEKMKQVAEEAARL--SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323

Query: 374  KLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAR------------------LMRQRE 415
            +L+  A   Q+ ++  Q Q  RLQ+DK+Q+ ++ A                   +  + E
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383

Query: 416  ELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGL-- 473
             L+ +VA   + QA    R EE      ++A EI    ++L  ++    +K++ +  L  
Sbjct: 2384 RLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEI 2436

Query: 474  -RSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDA 532
             R Q       LRE   +L   ++    +   L+L   E+     +  L      + Q  
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSF 2495

Query: 533  LATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARE 592
            L+  E D    R +      A L  +  +  A  +     LR E  R Q ++  ER   +
Sbjct: 2496 LS--EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ----LREEQQRQQQQMEQER---Q 2546

Query: 593  RQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
            R  AS  E RR   E +E V   Q++LQ    ++ Q+ +Q E  L E
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAE 2589



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 79/340 (23%), Positives = 143/340 (42%), Gaps = 36/340 (10%)

Query: 322  QELEERLWEK---EQEVAALRR-SLEQSEAAVAQV-----LEERQKAWERELAELRQGCS 372
            +E EER+ +    E+E A  R+ +LE+ E   A+V     L ER +       +L Q  +
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043

Query: 373  GKLQQVARRA-----QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE 427
             K  Q   +A     Q+ +Q LQ  + + Q    QL+ EA    R  EE E+     ++E
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103

Query: 428  QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
             A    ++EE +  + Q A E +  + Q + +   + ++  +    R+Q  +  A+LR+K
Sbjct: 2104 AAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ--AALRQK 2160

Query: 488  EEQLLSL-RDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
            +     + +    ++Q   +  + E     L+  L      E  D       +E +  + 
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL------EETDHQKNLLDEELQRLKA 2214

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA---RERQGAS-FAEER 602
                AA     V+ E         R    E+ +L+A + AE RA   R++     F +E 
Sbjct: 2215 EATEAARQRSQVEEEL-----FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2269

Query: 603  RVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGA 642
                E+ ++V E   +L ++  E  +  Q  E  L ++ A
Sbjct: 2270 ---AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2306



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 84/323 (26%), Positives = 128/323 (39%), Gaps = 36/323 (11%)

Query: 320  LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
            L+ E  +RL  +  E A  R  +E+   +V   +EE  K   R  AE R         + 
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR-------ALIL 2256

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
            R     Q+ LQ +  ++    KQ+ EEAARL    +E        +++ A      E+  
Sbjct: 2257 RDKDNTQRFLQEEAEKM----KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312

Query: 440  WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
             E  Q   E + LK     ++A++ Q+  E+        + R    +KE+    L +   
Sbjct: 2313 KEKMQAVQEATRLK-----AEAELLQQQKELA-----QEQARRLQEDKEQMAQQLAEETQ 2362

Query: 500  SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
              Q +LE           +     +  AE   A A  E D  + R+QA          + 
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE----KLH 2418

Query: 560  GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
                A  E  T     E+ R Q++  AE R RE    + AE  R    EKEK+ +  K L
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAE-RLRE----AIAELER----EKEKLQQEAKLL 2469

Query: 620  QLSYVEMYQRNQQLERRLRERGA 642
            QL   EM  +  Q E+ L+E  A
Sbjct: 2470 QLKSEEM--QTVQQEQLLQETQA 2490



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 12/172 (6%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            I ELE    + +QE   L+   E+ +    + L +  +A ++     +     + + + +
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
               + +Q  Q +V + Q    QL+EE  R  +Q E+   ++ A  +E      R  E + 
Sbjct: 2512 EKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEAR---RRQHEAEE 2564

Query: 441  EVCQKAGEISLLKQQLKDSQ---ADVSQKLSEIVGLRSQLREGRASLREKEE 489
             V +K  E+  L+QQ +  +   A+ +Q+L E + L  +  + RA+L   EE
Sbjct: 2565 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE--QHRAALAHSEE 2614



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 22/116 (18%)

Query: 332  EQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGL-- 389
            EQE A L + L Q E A AQ L E Q+  ++++ + RQ     +++  RR   A++G+  
Sbjct: 2510 EQEKAKLEQ-LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568

Query: 390  ------QLQVLRLQQDK-------------KQLQEEAARLMRQREELEDKVAACQK 426
                  QL+  R QQ++             + L+E+    +   EE+     A  K
Sbjct: 2569 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 99/350 (28%), Positives = 150/350 (42%), Gaps = 55/350 (15%)

Query: 338  LRRSLEQSEAAVAQVLEERQKAWERELA-----ELRQGCSGKLQQVARRAQRAQQGLQLQ 392
            LRR  E+   A  Q  EER++  E E A     +L +  +    Q  R A+  QQ +Q +
Sbjct: 1309 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1368

Query: 393  VLR-------LQQDKKQLQEEAARLMRQREELEDKVAACQKEQAD-FLPRIEETKWEVCQ 444
            V+R        QQ K+ +QEE  +L RQ  E E +  A Q E A+    RIEE       
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEE------- 1420

Query: 445  KAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLR-----DSFS 499
               EI +++ QL+ ++        E+  LR++  E  A  R+ +E+   LR     +S  
Sbjct: 1421 ---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477

Query: 500  SKQASLELG---EGELPAACLKP-ALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASL 555
             +QA +EL    + E  AA  K  AL  ++    Q   A     +A++ R   V  A   
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1537

Query: 556  VSVDGEAEAGGESGT---------RALRRE-VGRLQAELAAERRARERQGASFAEE---- 601
                 EAE   +  +         R+L+ E V   Q    AERRA+++  A  A E    
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597

Query: 602  --RRVWLEEKE------KVIEYQKQLQLSYVEMYQRNQQLERRLRERGAA 643
               R  L+  E      +  E  +Q  L+  E  ++ ++ ER  R RG A
Sbjct: 1598 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1647



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 93/382 (24%), Positives = 171/382 (44%), Gaps = 59/382 (15%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQV-------------LEERQKAWERELAELR 368
            Q LEE L   ++E AA  +  ++ EA +A+V              EE  ++   +  +  
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1757

Query: 369  QGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREE-LEDKVAACQ-- 425
            +  +G+ +++A  A R    L+      ++ ++  +E+AAR   + E  L +K+AA    
Sbjct: 1758 EAEAGRFRELAEEAAR----LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1813

Query: 426  ---KEQADFLPRIEETKWEVCQKAGEISL-----LKQQLKDSQADVSQKL--------SE 469
               K +A+   + +E + E  ++  E        L++Q    +AD+ ++L        SE
Sbjct: 1814 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1873

Query: 470  IVGLRSQLREGRASLREKEEQLLSLRDSF---SSKQASLELGEGELPAACLKPALTPVDP 526
            +   +  + +     R+ EE++L+L+ SF   ++ +A LEL  G + +   +  L   + 
Sbjct: 1874 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA-EDTLRSKEQ 1932

Query: 527  AEPQDALAT-CESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELA 585
            AE + A      ++E + RR+A      SL +   E EA  +   +A   EV RL+A++ 
Sbjct: 1933 AELEAARQRQLAAEEERRRREAEERVQKSLAA---EEEAARQR--KAALEEVERLKAKVE 1987

Query: 586  AERRARER---------QGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERR 636
              RR RER         Q A  A ++R+  EEK      Q++ Q    E+ Q  QQ +  
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ----ELQQTLQQEQSV 2043

Query: 637  LRERGAAGGASTPTPQHGEEKK 658
            L +      A+    +  EE +
Sbjct: 2044 LDQLRGEAEAARRAAEEAEEAR 2065



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 84/370 (22%), Positives = 161/370 (43%), Gaps = 33/370 (8%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGC--SGKLQQVA 379
            QEL++ L +++  +  LR   E +  A  +  E R +A ERE A+ R+    + +L+Q A
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA-EREAAQSRRQVEEAERLKQSA 2089

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
                +A+   Q    +L   +K+ ++EAAR  +  +    +  A   E        E+T 
Sbjct: 2090 EEQAQARAQAQAAAEKL---RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146

Query: 440  WEVCQKAGEISLLKQQLKDSQAD----------VSQKLSEIVGLRSQLREGRASLREKEE 489
             +  Q   E++ L+ QL+++             +  + +E    RSQ+ E   S+R + E
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2206

Query: 490  QLLSLRDSFSSKQASLELGEGELPAACLKPALTPV-DPAEPQDALATCESDEAKMRRQA- 547
            +L  L+    ++  +L L + +     L+     +   AE    L+    + A++R+ A 
Sbjct: 2207 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2266

Query: 548  -GVAAAASLVS--VDGEAEAGGESGTRALRREVGRLQAELAAERRAR-----ERQGASFA 599
              +A   +L    +  + +A  E+       E+ + Q ELA E+  R     E+     A
Sbjct: 2267 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2326

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            EE + +    ++ +E ++Q QL   EM    ++L+ R+ E   A   +    Q   ++  
Sbjct: 2327 EETQGF----QRTLEAERQRQL---EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2379

Query: 660  WTPSRLERIE 669
                +L R E
Sbjct: 2380 EIGEKLHRTE 2389



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 91/369 (24%), Positives = 153/369 (41%), Gaps = 47/369 (12%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            +Q LEE   + E+    LR++  +    V   LE  Q++ E EL   R   + K  Q+ R
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1562

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLP---RIEE 437
              Q       + V +L+++ ++  ++ A   R REE E ++   Q +  + L    + EE
Sbjct: 1563 SLQEEH----VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1618

Query: 438  TKWEVCQKAGEISLLKQQLK---------DSQADVSQKLSE-IVGLRSQLREGRASLR-E 486
               +      E    K++ +         + QA   ++L+E  +  + QL EG A  R  
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1678

Query: 487  KEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
             E++L+ LR      +   +L E EL       A    + A         E++ AK+R +
Sbjct: 1679 AEQELIRLRAETEQGEQQRQLLEEEL-------ARLQREAAAATQKRQELEAELAKVRAE 1731

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWL 606
              V   AS    + E+ +  E   + L  E GR +    AE  AR R   + AEE +   
Sbjct: 1732 MEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRE--LAEEAARLR---ALAEEAK--- 1782

Query: 607  EEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGE---EKKAWTPS 663
                      +Q QL+  +  ++  + ER L E+ AA G +T      E   ++K     
Sbjct: 1783 ----------RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1832

Query: 664  RLERIESTE 672
            RL R+   E
Sbjct: 1833 RLRRLAEDE 1841



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 55/370 (14%)

Query: 322  QELEERLWEKEQEVAALRRS----LEQSEAAVAQVLEERQKAWE---RELAELRQGCS-- 372
            + L++R  E++ EV   R      LE+ +A +AQ  + RQ+  E   R+L   R+     
Sbjct: 1129 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1187

Query: 373  GKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFL 432
            G   Q ARR Q   Q + L     Q  ++QL++E A L+ + E   +KV  CQ+    ++
Sbjct: 1188 GAWLQDARRRQEQIQAMPLA--DSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYI 1244

Query: 433  PRIEETKWEVCQKAGEISLLKQQLK------------DSQADVSQKLSEIVGLRSQ-LRE 479
              I++ + ++     ++  +    K                D+    SE+  L SQ ++ 
Sbjct: 1245 NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1304

Query: 480  GRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESD 539
               +LR  EE+     +  + +Q + E        A L+      +      A A  E+ 
Sbjct: 1305 ISETLRRMEEE-----ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1359

Query: 540  EAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFA 599
            E + R Q  V           EA    +   R+++ E+ +L+    AE +A+ RQ A  A
Sbjct: 1360 ELQQRMQEEVVRRE-------EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAA 1411

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            E  R+ +EE+ +V+                  QLE   R+RG A G         EE +A
Sbjct: 1412 ERSRLRIEEEIRVVRL----------------QLEATERQRGGAEGELQALRARAEEAEA 1455

Query: 660  WTPSRLERIE 669
                  E  E
Sbjct: 1456 QKRQAQEEAE 1465



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 87/393 (22%), Positives = 157/393 (39%), Gaps = 44/393 (11%)

Query: 322  QELEERLWEKEQEVA--ALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQ-QV 378
            +E  ER  E+ Q  A  ALR  L+  E A  + L + +   ++E AE      GK + Q 
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651

Query: 379  ARRAQRAQQGLQLQV----------LRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQ 428
             R+ + A+Q L+ Q           L  +Q+  +L+ E  +  +QR+ LE+++A  Q+E 
Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1711

Query: 429  ADFLPRIEETKWEVCQKAGEISLL-------KQQLKDSQADVSQKLSEIVGLRSQLREGR 481
            A    + +E + E+ +   E+ +L       +++ + +     Q+L    G   +L E  
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771

Query: 482  ASLR------EKEEQLLSLRDSFSSKQASLELGE-----GELPAACLKPALTPVDPAEPQ 530
            A LR      +++ QL     +    +A   L E     GE      +  +   +     
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831

Query: 531  DALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA 590
            + L     DEA  RR+    AA     ++       ++    L R+ G ++  L   R+ 
Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1891

Query: 591  RER---QGASF----AEERRVWLE------EKEKVIEYQKQLQLSYVEMYQRNQQLERRL 637
             E      ASF    A +  + LE        E  +  ++Q +L      Q   + ERR 
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1951

Query: 638  RERGAAGGASTPTPQHGEEKKAWTPSRLERIES 670
            RE       S    +    ++      +ER+++
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 51/347 (14%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAE--LRQGCSG----- 373
            +QE  E++ +  +E A L  S+   EAA  + L E   A +R LAE  L++         
Sbjct: 2234 LQEEAEKMKQVAEEAARL--SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2291

Query: 374  KLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAR------------------LMRQRE 415
            +L+  A   Q+ ++  Q Q  RLQ+DK+Q+ ++ A                   +  + E
Sbjct: 2292 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2351

Query: 416  ELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGL-- 473
             L+ +VA   + QA    R EE      ++A EI    ++L  ++    +K++ +  L  
Sbjct: 2352 RLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEI 2404

Query: 474  -RSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDA 532
             R Q       LRE   +L   ++    +   L+L   E+     +  L      + Q  
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSF 2463

Query: 533  LATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARE 592
            L+  E D    R +      A L  +  +  A  +     LR E  R Q ++  ER   +
Sbjct: 2464 LS--EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ----LREEQQRQQQQMEQER---Q 2514

Query: 593  RQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
            R  AS  E RR   E +E V   Q++LQ    ++ Q+ +Q E  L E
Sbjct: 2515 RLVASMEEARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAE 2557



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 79/340 (23%), Positives = 143/340 (42%), Gaps = 36/340 (10%)

Query: 322  QELEERLWEK---EQEVAALRR-SLEQSEAAVAQV-----LEERQKAWERELAELRQGCS 372
            +E EER+ +    E+E A  R+ +LE+ E   A+V     L ER +       +L Q  +
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011

Query: 373  GKLQQVARRA-----QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE 427
             K  Q   +A     Q+ +Q LQ  + + Q    QL+ EA    R  EE E+     ++E
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2071

Query: 428  QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
             A    ++EE +  + Q A E +  + Q + +   + ++  +    R+Q  +  A+LR+K
Sbjct: 2072 AAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ--AALRQK 2128

Query: 488  EEQLLSL-RDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
            +     + +    ++Q   +  + E     L+  L      E  D       +E +  + 
Sbjct: 2129 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL------EETDHQKNLLDEELQRLKA 2182

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA---RERQGAS-FAEER 602
                AA     V+ E         R    E+ +L+A + AE RA   R++     F +E 
Sbjct: 2183 EATEAARQRSQVEEEL-----FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2237

Query: 603  RVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGA 642
                E+ ++V E   +L ++  E  +  Q  E  L ++ A
Sbjct: 2238 ---AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2274



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 84/323 (26%), Positives = 128/323 (39%), Gaps = 36/323 (11%)

Query: 320  LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
            L+ E  +RL  +  E A  R  +E+   +V   +EE  K   R  AE R         + 
Sbjct: 2172 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR-------ALIL 2224

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
            R     Q+ LQ +  ++    KQ+ EEAARL    +E        +++ A      E+  
Sbjct: 2225 RDKDNTQRFLQEEAEKM----KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2280

Query: 440  WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
             E  Q   E + LK     ++A++ Q+  E+        + R    +KE+    L +   
Sbjct: 2281 KEKMQAVQEATRLK-----AEAELLQQQKELA-----QEQARRLQEDKEQMAQQLAEETQ 2330

Query: 500  SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
              Q +LE           +     +  AE   A A  E D  + R+QA          + 
Sbjct: 2331 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE----KLH 2386

Query: 560  GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
                A  E  T     E+ R Q++  AE R RE    + AE  R    EKEK+ +  K L
Sbjct: 2387 RTELATQEKVTLVQTLEIQRQQSDHDAE-RLRE----AIAELER----EKEKLQQEAKLL 2437

Query: 620  QLSYVEMYQRNQQLERRLRERGA 642
            QL   EM  +  Q E+ L+E  A
Sbjct: 2438 QLKSEEM--QTVQQEQLLQETQA 2458



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 12/172 (6%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            I ELE    + +QE   L+   E+ +    + L +  +A ++     +     + + + +
Sbjct: 2420 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2479

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
               + +Q  Q +V + Q    QL+EE  R  +Q E+   ++ A  +E      R  E + 
Sbjct: 2480 EKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEAR---RRQHEAEE 2532

Query: 441  EVCQKAGEISLLKQQLKDSQ---ADVSQKLSEIVGLRSQLREGRASLREKEE 489
             V +K  E+  L+QQ +  +   A+ +Q+L E + L  +  + RA+L   EE
Sbjct: 2533 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE--QHRAALAHSEE 2582



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 22/116 (18%)

Query: 332  EQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGL-- 389
            EQE A L + L Q E A AQ L E Q+  ++++ + RQ     +++  RR   A++G+  
Sbjct: 2478 EQEKAKLEQ-LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2536

Query: 390  ------QLQVLRLQQDK-------------KQLQEEAARLMRQREELEDKVAACQK 426
                  QL+  R QQ++             + L+E+    +   EE+     A  K
Sbjct: 2537 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2592


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 99/350 (28%), Positives = 150/350 (42%), Gaps = 55/350 (15%)

Query: 338  LRRSLEQSEAAVAQVLEERQKAWERELA-----ELRQGCSGKLQQVARRAQRAQQGLQLQ 392
            LRR  E+   A  Q  EER++  E E A     +L +  +    Q  R A+  QQ +Q +
Sbjct: 1478 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1537

Query: 393  VLR-------LQQDKKQLQEEAARLMRQREELEDKVAACQKEQAD-FLPRIEETKWEVCQ 444
            V+R        QQ K+ +QEE  +L RQ  E E +  A Q E A+    RIEE       
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEE------- 1589

Query: 445  KAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLR-----DSFS 499
               EI +++ QL+ ++        E+  LR++  E  A  R+ +E+   LR     +S  
Sbjct: 1590 ---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646

Query: 500  SKQASLELG---EGELPAACLKP-ALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASL 555
             +QA +EL    + E  AA  K  AL  ++    Q   A     +A++ R   V  A   
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1706

Query: 556  VSVDGEAEAGGESGT---------RALRRE-VGRLQAELAAERRARERQGASFAEE---- 601
                 EAE   +  +         R+L+ E V   Q    AERRA+++  A  A E    
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766

Query: 602  --RRVWLEEKE------KVIEYQKQLQLSYVEMYQRNQQLERRLRERGAA 643
               R  L+  E      +  E  +Q  L+  E  ++ ++ ER  R RG A
Sbjct: 1767 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1816



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 93/382 (24%), Positives = 171/382 (44%), Gaps = 59/382 (15%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQV-------------LEERQKAWERELAELR 368
            Q LEE L   ++E AA  +  ++ EA +A+V              EE  ++   +  +  
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1926

Query: 369  QGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREE-LEDKVAACQ-- 425
            +  +G+ +++A  A R    L+      ++ ++  +E+AAR   + E  L +K+AA    
Sbjct: 1927 EAEAGRFRELAEEAAR----LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1982

Query: 426  ---KEQADFLPRIEETKWEVCQKAGEISL-----LKQQLKDSQADVSQKL--------SE 469
               K +A+   + +E + E  ++  E        L++Q    +AD+ ++L        SE
Sbjct: 1983 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 2042

Query: 470  IVGLRSQLREGRASLREKEEQLLSLRDSF---SSKQASLELGEGELPAACLKPALTPVDP 526
            +   +  + +     R+ EE++L+L+ SF   ++ +A LEL  G + +   +  L   + 
Sbjct: 2043 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA-EDTLRSKEQ 2101

Query: 527  AEPQDALAT-CESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELA 585
            AE + A      ++E + RR+A      SL +   E EA  +   +A   EV RL+A++ 
Sbjct: 2102 AELEAARQRQLAAEEERRRREAEERVQKSLAA---EEEAARQR--KAALEEVERLKAKVE 2156

Query: 586  AERRARER---------QGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERR 636
              RR RER         Q A  A ++R+  EEK      Q++ Q    E+ Q  QQ +  
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ----ELQQTLQQEQSV 2212

Query: 637  LRERGAAGGASTPTPQHGEEKK 658
            L +      A+    +  EE +
Sbjct: 2213 LDQLRGEAEAARRAAEEAEEAR 2234



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 84/370 (22%), Positives = 161/370 (43%), Gaps = 33/370 (8%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGC--SGKLQQVA 379
            QEL++ L +++  +  LR   E +  A  +  E R +A ERE A+ R+    + +L+Q A
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA-EREAAQSRRQVEEAERLKQSA 2258

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
                +A+   Q    +L   +K+ ++EAAR  +  +    +  A   E        E+T 
Sbjct: 2259 EEQAQARAQAQAAAEKL---RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315

Query: 440  WEVCQKAGEISLLKQQLKDSQAD----------VSQKLSEIVGLRSQLREGRASLREKEE 489
             +  Q   E++ L+ QL+++             +  + +E    RSQ+ E   S+R + E
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2375

Query: 490  QLLSLRDSFSSKQASLELGEGELPAACLKPALTPV-DPAEPQDALATCESDEAKMRRQA- 547
            +L  L+    ++  +L L + +     L+     +   AE    L+    + A++R+ A 
Sbjct: 2376 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2435

Query: 548  -GVAAAASLVS--VDGEAEAGGESGTRALRREVGRLQAELAAERRAR-----ERQGASFA 599
              +A   +L    +  + +A  E+       E+ + Q ELA E+  R     E+     A
Sbjct: 2436 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2495

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            EE + +    ++ +E ++Q QL   EM    ++L+ R+ E   A   +    Q   ++  
Sbjct: 2496 EETQGF----QRTLEAERQRQL---EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2548

Query: 660  WTPSRLERIE 669
                +L R E
Sbjct: 2549 EIGEKLHRTE 2558



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 91/369 (24%), Positives = 153/369 (41%), Gaps = 47/369 (12%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            +Q LEE   + E+    LR++  +    V   LE  Q++ E EL   R   + K  Q+ R
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1731

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLP---RIEE 437
              Q       + V +L+++ ++  ++ A   R REE E ++   Q +  + L    + EE
Sbjct: 1732 SLQEEH----VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1787

Query: 438  TKWEVCQKAGEISLLKQQLK---------DSQADVSQKLSE-IVGLRSQLREGRASLR-E 486
               +      E    K++ +         + QA   ++L+E  +  + QL EG A  R  
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1847

Query: 487  KEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
             E++L+ LR      +   +L E EL       A    + A         E++ AK+R +
Sbjct: 1848 AEQELIRLRAETEQGEQQRQLLEEEL-------ARLQREAAAATQKRQELEAELAKVRAE 1900

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWL 606
              V   AS    + E+ +  E   + L  E GR +    AE  AR R   + AEE +   
Sbjct: 1901 MEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRE--LAEEAARLR---ALAEEAK--- 1951

Query: 607  EEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGE---EKKAWTPS 663
                      +Q QL+  +  ++  + ER L E+ AA G +T      E   ++K     
Sbjct: 1952 ----------RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 2001

Query: 664  RLERIESTE 672
            RL R+   E
Sbjct: 2002 RLRRLAEDE 2010



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 55/370 (14%)

Query: 322  QELEERLWEKEQEVAALRRS----LEQSEAAVAQVLEERQKAWE---RELAELRQGCS-- 372
            + L++R  E++ EV   R      LE+ +A +AQ  + RQ+  E   R+L   R+     
Sbjct: 1298 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1356

Query: 373  GKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFL 432
            G   Q ARR Q   Q + L     Q  ++QL++E A L+ + E   +KV  CQ+    ++
Sbjct: 1357 GAWLQDARRRQEQIQAMPLA--DSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYI 1413

Query: 433  PRIEETKWEVCQKAGEISLLKQQLK------------DSQADVSQKLSEIVGLRSQ-LRE 479
              I++ + ++     ++  +    K                D+    SE+  L SQ ++ 
Sbjct: 1414 NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1473

Query: 480  GRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESD 539
               +LR  EE+     +  + +Q + E        A L+      +      A A  E+ 
Sbjct: 1474 ISETLRRMEEE-----ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1528

Query: 540  EAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFA 599
            E + R Q  V           EA    +   R+++ E+ +L+    AE +A+ RQ A  A
Sbjct: 1529 ELQQRMQEEVVRRE-------EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAA 1580

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            E  R+ +EE+ +V+                  QLE   R+RG A G         EE +A
Sbjct: 1581 ERSRLRIEEEIRVVRL----------------QLEATERQRGGAEGELQALRARAEEAEA 1624

Query: 660  WTPSRLERIE 669
                  E  E
Sbjct: 1625 QKRQAQEEAE 1634



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 87/393 (22%), Positives = 157/393 (39%), Gaps = 44/393 (11%)

Query: 322  QELEERLWEKEQEVA--ALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQ-QV 378
            +E  ER  E+ Q  A  ALR  L+  E A  + L + +   ++E AE      GK + Q 
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820

Query: 379  ARRAQRAQQGLQLQV----------LRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQ 428
             R+ + A+Q L+ Q           L  +Q+  +L+ E  +  +QR+ LE+++A  Q+E 
Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1880

Query: 429  ADFLPRIEETKWEVCQKAGEISLL-------KQQLKDSQADVSQKLSEIVGLRSQLREGR 481
            A    + +E + E+ +   E+ +L       +++ + +     Q+L    G   +L E  
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940

Query: 482  ASLR------EKEEQLLSLRDSFSSKQASLELGE-----GELPAACLKPALTPVDPAEPQ 530
            A LR      +++ QL     +    +A   L E     GE      +  +   +     
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000

Query: 531  DALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA 590
            + L     DEA  RR+    AA     ++       ++    L R+ G ++  L   R+ 
Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060

Query: 591  RER---QGASF----AEERRVWLE------EKEKVIEYQKQLQLSYVEMYQRNQQLERRL 637
             E      ASF    A +  + LE        E  +  ++Q +L      Q   + ERR 
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2120

Query: 638  RERGAAGGASTPTPQHGEEKKAWTPSRLERIES 670
            RE       S    +    ++      +ER+++
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKA 2153



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 51/347 (14%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAE--LRQGCSG----- 373
            +QE  E++ +  +E A L  S+   EAA  + L E   A +R LAE  L++         
Sbjct: 2403 LQEEAEKMKQVAEEAARL--SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2460

Query: 374  KLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAR------------------LMRQRE 415
            +L+  A   Q+ ++  Q Q  RLQ+DK+Q+ ++ A                   +  + E
Sbjct: 2461 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520

Query: 416  ELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGL-- 473
             L+ +VA   + QA    R EE      ++A EI    ++L  ++    +K++ +  L  
Sbjct: 2521 RLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEI 2573

Query: 474  -RSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDA 532
             R Q       LRE   +L   ++    +   L+L   E+     +  L      + Q  
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSF 2632

Query: 533  LATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARE 592
            L+  E D    R +      A L  +  +  A  +     LR E  R Q ++  ER   +
Sbjct: 2633 LS--EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ----LREEQQRQQQQMEQER---Q 2683

Query: 593  RQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
            R  AS  E RR   E +E V   Q++LQ    ++ Q+ +Q E  L E
Sbjct: 2684 RLVASMEEARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAE 2726



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 79/340 (23%), Positives = 143/340 (42%), Gaps = 36/340 (10%)

Query: 322  QELEERLWEK---EQEVAALRR-SLEQSEAAVAQV-----LEERQKAWERELAELRQGCS 372
            +E EER+ +    E+E A  R+ +LE+ E   A+V     L ER +       +L Q  +
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180

Query: 373  GKLQQVARRA-----QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE 427
             K  Q   +A     Q+ +Q LQ  + + Q    QL+ EA    R  EE E+     ++E
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2240

Query: 428  QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
             A    ++EE +  + Q A E +  + Q + +   + ++  +    R+Q  +  A+LR+K
Sbjct: 2241 AAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ--AALRQK 2297

Query: 488  EEQLLSL-RDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
            +     + +    ++Q   +  + E     L+  L      E  D       +E +  + 
Sbjct: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL------EETDHQKNLLDEELQRLKA 2351

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA---RERQGAS-FAEER 602
                AA     V+ E         R    E+ +L+A + AE RA   R++     F +E 
Sbjct: 2352 EATEAARQRSQVEEEL-----FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2406

Query: 603  RVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGA 642
                E+ ++V E   +L ++  E  +  Q  E  L ++ A
Sbjct: 2407 ---AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2443



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 84/323 (26%), Positives = 128/323 (39%), Gaps = 36/323 (11%)

Query: 320  LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
            L+ E  +RL  +  E A  R  +E+   +V   +EE  K   R  AE R         + 
Sbjct: 2341 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR-------ALIL 2393

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
            R     Q+ LQ +  ++    KQ+ EEAARL    +E        +++ A      E+  
Sbjct: 2394 RDKDNTQRFLQEEAEKM----KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2449

Query: 440  WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
             E  Q   E + LK     ++A++ Q+  E+        + R    +KE+    L +   
Sbjct: 2450 KEKMQAVQEATRLK-----AEAELLQQQKELA-----QEQARRLQEDKEQMAQQLAEETQ 2499

Query: 500  SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
              Q +LE           +     +  AE   A A  E D  + R+QA          + 
Sbjct: 2500 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE----KLH 2555

Query: 560  GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
                A  E  T     E+ R Q++  AE R RE    + AE  R    EKEK+ +  K L
Sbjct: 2556 RTELATQEKVTLVQTLEIQRQQSDHDAE-RLRE----AIAELER----EKEKLQQEAKLL 2606

Query: 620  QLSYVEMYQRNQQLERRLRERGA 642
            QL   EM  +  Q E+ L+E  A
Sbjct: 2607 QLKSEEM--QTVQQEQLLQETQA 2627



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 12/172 (6%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            I ELE    + +QE   L+   E+ +    + L +  +A ++     +     + + + +
Sbjct: 2589 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2648

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
               + +Q  Q +V + Q    QL+EE  R  +Q E+   ++ A  +E      R  E + 
Sbjct: 2649 EKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEAR---RRQHEAEE 2701

Query: 441  EVCQKAGEISLLKQQLKDSQ---ADVSQKLSEIVGLRSQLREGRASLREKEE 489
             V +K  E+  L+QQ +  +   A+ +Q+L E + L  +  + RA+L   EE
Sbjct: 2702 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE--QHRAALAHSEE 2751



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 22/116 (18%)

Query: 332  EQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGL-- 389
            EQE A L + L Q E A AQ L E Q+  ++++ + RQ     +++  RR   A++G+  
Sbjct: 2647 EQEKAKLEQ-LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2705

Query: 390  ------QLQVLRLQQDK-------------KQLQEEAARLMRQREELEDKVAACQK 426
                  QL+  R QQ++             + L+E+    +   EE+     A  K
Sbjct: 2706 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2761


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 99/350 (28%), Positives = 150/350 (42%), Gaps = 55/350 (15%)

Query: 338  LRRSLEQSEAAVAQVLEERQKAWERELA-----ELRQGCSGKLQQVARRAQRAQQGLQLQ 392
            LRR  E+   A  Q  EER++  E E A     +L +  +    Q  R A+  QQ +Q +
Sbjct: 1319 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1378

Query: 393  VLR-------LQQDKKQLQEEAARLMRQREELEDKVAACQKEQAD-FLPRIEETKWEVCQ 444
            V+R        QQ K+ +QEE  +L RQ  E E +  A Q E A+    RIEE       
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEE------- 1430

Query: 445  KAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLR-----DSFS 499
               EI +++ QL+ ++        E+  LR++  E  A  R+ +E+   LR     +S  
Sbjct: 1431 ---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487

Query: 500  SKQASLELG---EGELPAACLKP-ALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASL 555
             +QA +EL    + E  AA  K  AL  ++    Q   A     +A++ R   V  A   
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1547

Query: 556  VSVDGEAEAGGESGT---------RALRRE-VGRLQAELAAERRARERQGASFAEE---- 601
                 EAE   +  +         R+L+ E V   Q    AERRA+++  A  A E    
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607

Query: 602  --RRVWLEEKE------KVIEYQKQLQLSYVEMYQRNQQLERRLRERGAA 643
               R  L+  E      +  E  +Q  L+  E  ++ ++ ER  R RG A
Sbjct: 1608 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1657



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 93/382 (24%), Positives = 171/382 (44%), Gaps = 59/382 (15%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQV-------------LEERQKAWERELAELR 368
            Q LEE L   ++E AA  +  ++ EA +A+V              EE  ++   +  +  
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1767

Query: 369  QGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREE-LEDKVAACQ-- 425
            +  +G+ +++A  A R    L+      ++ ++  +E+AAR   + E  L +K+AA    
Sbjct: 1768 EAEAGRFRELAEEAAR----LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1823

Query: 426  ---KEQADFLPRIEETKWEVCQKAGEISL-----LKQQLKDSQADVSQKL--------SE 469
               K +A+   + +E + E  ++  E        L++Q    +AD+ ++L        SE
Sbjct: 1824 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1883

Query: 470  IVGLRSQLREGRASLREKEEQLLSLRDSF---SSKQASLELGEGELPAACLKPALTPVDP 526
            +   +  + +     R+ EE++L+L+ SF   ++ +A LEL  G + +   +  L   + 
Sbjct: 1884 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA-EDTLRSKEQ 1942

Query: 527  AEPQDALAT-CESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELA 585
            AE + A      ++E + RR+A      SL +   E EA  +   +A   EV RL+A++ 
Sbjct: 1943 AELEAARQRQLAAEEERRRREAEERVQKSLAA---EEEAARQR--KAALEEVERLKAKVE 1997

Query: 586  AERRARER---------QGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERR 636
              RR RER         Q A  A ++R+  EEK      Q++ Q    E+ Q  QQ +  
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ----ELQQTLQQEQSV 2053

Query: 637  LRERGAAGGASTPTPQHGEEKK 658
            L +      A+    +  EE +
Sbjct: 2054 LDQLRGEAEAARRAAEEAEEAR 2075



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 84/370 (22%), Positives = 161/370 (43%), Gaps = 33/370 (8%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGC--SGKLQQVA 379
            QEL++ L +++  +  LR   E +  A  +  E R +A ERE A+ R+    + +L+Q A
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA-EREAAQSRRQVEEAERLKQSA 2099

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
                +A+   Q    +L   +K+ ++EAAR  +  +    +  A   E        E+T 
Sbjct: 2100 EEQAQARAQAQAAAEKL---RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156

Query: 440  WEVCQKAGEISLLKQQLKDSQAD----------VSQKLSEIVGLRSQLREGRASLREKEE 489
             +  Q   E++ L+ QL+++             +  + +E    RSQ+ E   S+R + E
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2216

Query: 490  QLLSLRDSFSSKQASLELGEGELPAACLKPALTPV-DPAEPQDALATCESDEAKMRRQA- 547
            +L  L+    ++  +L L + +     L+     +   AE    L+    + A++R+ A 
Sbjct: 2217 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2276

Query: 548  -GVAAAASLVS--VDGEAEAGGESGTRALRREVGRLQAELAAERRAR-----ERQGASFA 599
              +A   +L    +  + +A  E+       E+ + Q ELA E+  R     E+     A
Sbjct: 2277 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2336

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            EE + +    ++ +E ++Q QL   EM    ++L+ R+ E   A   +    Q   ++  
Sbjct: 2337 EETQGF----QRTLEAERQRQL---EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2389

Query: 660  WTPSRLERIE 669
                +L R E
Sbjct: 2390 EIGEKLHRTE 2399



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 91/369 (24%), Positives = 153/369 (41%), Gaps = 47/369 (12%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            +Q LEE   + E+    LR++  +    V   LE  Q++ E EL   R   + K  Q+ R
Sbjct: 1513 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1572

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLP---RIEE 437
              Q       + V +L+++ ++  ++ A   R REE E ++   Q +  + L    + EE
Sbjct: 1573 SLQEEH----VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1628

Query: 438  TKWEVCQKAGEISLLKQQLK---------DSQADVSQKLSE-IVGLRSQLREGRASLR-E 486
               +      E    K++ +         + QA   ++L+E  +  + QL EG A  R  
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1688

Query: 487  KEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
             E++L+ LR      +   +L E EL       A    + A         E++ AK+R +
Sbjct: 1689 AEQELIRLRAETEQGEQQRQLLEEEL-------ARLQREAAAATQKRQELEAELAKVRAE 1741

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWL 606
              V   AS    + E+ +  E   + L  E GR +    AE  AR R   + AEE +   
Sbjct: 1742 MEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRE--LAEEAARLR---ALAEEAK--- 1792

Query: 607  EEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGE---EKKAWTPS 663
                      +Q QL+  +  ++  + ER L E+ AA G +T      E   ++K     
Sbjct: 1793 ----------RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1842

Query: 664  RLERIESTE 672
            RL R+   E
Sbjct: 1843 RLRRLAEDE 1851



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 55/370 (14%)

Query: 322  QELEERLWEKEQEVAALRRS----LEQSEAAVAQVLEERQKAWE---RELAELRQGCS-- 372
            + L++R  E++ EV   R      LE+ +A +AQ  + RQ+  E   R+L   R+     
Sbjct: 1139 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1197

Query: 373  GKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFL 432
            G   Q ARR Q   Q + L     Q  ++QL++E A L+ + E   +KV  CQ+    ++
Sbjct: 1198 GAWLQDARRRQEQIQAMPLA--DSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYI 1254

Query: 433  PRIEETKWEVCQKAGEISLLKQQLK------------DSQADVSQKLSEIVGLRSQ-LRE 479
              I++ + ++     ++  +    K                D+    SE+  L SQ ++ 
Sbjct: 1255 NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1314

Query: 480  GRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESD 539
               +LR  EE+     +  + +Q + E        A L+      +      A A  E+ 
Sbjct: 1315 ISETLRRMEEE-----ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1369

Query: 540  EAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFA 599
            E + R Q  V           EA    +   R+++ E+ +L+    AE +A+ RQ A  A
Sbjct: 1370 ELQQRMQEEVVRRE-------EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAA 1421

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            E  R+ +EE+ +V+                  QLE   R+RG A G         EE +A
Sbjct: 1422 ERSRLRIEEEIRVVRL----------------QLEATERQRGGAEGELQALRARAEEAEA 1465

Query: 660  WTPSRLERIE 669
                  E  E
Sbjct: 1466 QKRQAQEEAE 1475



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 87/393 (22%), Positives = 157/393 (39%), Gaps = 44/393 (11%)

Query: 322  QELEERLWEKEQEVA--ALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQ-QV 378
            +E  ER  E+ Q  A  ALR  L+  E A  + L + +   ++E AE      GK + Q 
Sbjct: 1602 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661

Query: 379  ARRAQRAQQGLQLQV----------LRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQ 428
             R+ + A+Q L+ Q           L  +Q+  +L+ E  +  +QR+ LE+++A  Q+E 
Sbjct: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1721

Query: 429  ADFLPRIEETKWEVCQKAGEISLL-------KQQLKDSQADVSQKLSEIVGLRSQLREGR 481
            A    + +E + E+ +   E+ +L       +++ + +     Q+L    G   +L E  
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781

Query: 482  ASLR------EKEEQLLSLRDSFSSKQASLELGE-----GELPAACLKPALTPVDPAEPQ 530
            A LR      +++ QL     +    +A   L E     GE      +  +   +     
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841

Query: 531  DALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA 590
            + L     DEA  RR+    AA     ++       ++    L R+ G ++  L   R+ 
Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901

Query: 591  RER---QGASF----AEERRVWLE------EKEKVIEYQKQLQLSYVEMYQRNQQLERRL 637
             E      ASF    A +  + LE        E  +  ++Q +L      Q   + ERR 
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1961

Query: 638  RERGAAGGASTPTPQHGEEKKAWTPSRLERIES 670
            RE       S    +    ++      +ER+++
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 51/347 (14%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAE--LRQGCSG----- 373
            +QE  E++ +  +E A L  S+   EAA  + L E   A +R LAE  L++         
Sbjct: 2244 LQEEAEKMKQVAEEAARL--SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2301

Query: 374  KLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAR------------------LMRQRE 415
            +L+  A   Q+ ++  Q Q  RLQ+DK+Q+ ++ A                   +  + E
Sbjct: 2302 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2361

Query: 416  ELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGL-- 473
             L+ +VA   + QA    R EE      ++A EI    ++L  ++    +K++ +  L  
Sbjct: 2362 RLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEI 2414

Query: 474  -RSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDA 532
             R Q       LRE   +L   ++    +   L+L   E+     +  L      + Q  
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSF 2473

Query: 533  LATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARE 592
            L+  E D    R +      A L  +  +  A  +     LR E  R Q ++  ER   +
Sbjct: 2474 LS--EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ----LREEQQRQQQQMEQER---Q 2524

Query: 593  RQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
            R  AS  E RR   E +E V   Q++LQ    ++ Q+ +Q E  L E
Sbjct: 2525 RLVASMEEARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAE 2567



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 79/340 (23%), Positives = 143/340 (42%), Gaps = 36/340 (10%)

Query: 322  QELEERLWEK---EQEVAALRR-SLEQSEAAVAQV-----LEERQKAWERELAELRQGCS 372
            +E EER+ +    E+E A  R+ +LE+ E   A+V     L ER +       +L Q  +
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021

Query: 373  GKLQQVARRA-----QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE 427
             K  Q   +A     Q+ +Q LQ  + + Q    QL+ EA    R  EE E+     ++E
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2081

Query: 428  QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
             A    ++EE +  + Q A E +  + Q + +   + ++  +    R+Q  +  A+LR+K
Sbjct: 2082 AAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ--AALRQK 2138

Query: 488  EEQLLSL-RDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
            +     + +    ++Q   +  + E     L+  L      E  D       +E +  + 
Sbjct: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL------EETDHQKNLLDEELQRLKA 2192

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA---RERQGAS-FAEER 602
                AA     V+ E         R    E+ +L+A + AE RA   R++     F +E 
Sbjct: 2193 EATEAARQRSQVEEEL-----FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2247

Query: 603  RVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGA 642
                E+ ++V E   +L ++  E  +  Q  E  L ++ A
Sbjct: 2248 ---AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2284



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 84/323 (26%), Positives = 128/323 (39%), Gaps = 36/323 (11%)

Query: 320  LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
            L+ E  +RL  +  E A  R  +E+   +V   +EE  K   R  AE R         + 
Sbjct: 2182 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR-------ALIL 2234

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
            R     Q+ LQ +  ++    KQ+ EEAARL    +E        +++ A      E+  
Sbjct: 2235 RDKDNTQRFLQEEAEKM----KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2290

Query: 440  WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
             E  Q   E + LK     ++A++ Q+  E+        + R    +KE+    L +   
Sbjct: 2291 KEKMQAVQEATRLK-----AEAELLQQQKELA-----QEQARRLQEDKEQMAQQLAEETQ 2340

Query: 500  SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
              Q +LE           +     +  AE   A A  E D  + R+QA          + 
Sbjct: 2341 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE----KLH 2396

Query: 560  GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
                A  E  T     E+ R Q++  AE R RE    + AE  R    EKEK+ +  K L
Sbjct: 2397 RTELATQEKVTLVQTLEIQRQQSDHDAE-RLRE----AIAELER----EKEKLQQEAKLL 2447

Query: 620  QLSYVEMYQRNQQLERRLRERGA 642
            QL   EM  +  Q E+ L+E  A
Sbjct: 2448 QLKSEEM--QTVQQEQLLQETQA 2468



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 12/172 (6%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            I ELE    + +QE   L+   E+ +    + L +  +A ++     +     + + + +
Sbjct: 2430 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2489

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
               + +Q  Q +V + Q    QL+EE  R  +Q E+   ++ A  +E      R  E + 
Sbjct: 2490 EKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEAR---RRQHEAEE 2542

Query: 441  EVCQKAGEISLLKQQLKDSQ---ADVSQKLSEIVGLRSQLREGRASLREKEE 489
             V +K  E+  L+QQ +  +   A+ +Q+L E + L  +  + RA+L   EE
Sbjct: 2543 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE--QHRAALAHSEE 2592



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 22/116 (18%)

Query: 332  EQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGL-- 389
            EQE A L + L Q E A AQ L E Q+  ++++ + RQ     +++  RR   A++G+  
Sbjct: 2488 EQEKAKLEQ-LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2546

Query: 390  ------QLQVLRLQQDK-------------KQLQEEAARLMRQREELEDKVAACQK 426
                  QL+  R QQ++             + L+E+    +   EE+     A  K
Sbjct: 2547 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2602


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 99/350 (28%), Positives = 150/350 (42%), Gaps = 55/350 (15%)

Query: 338  LRRSLEQSEAAVAQVLEERQKAWERELA-----ELRQGCSGKLQQVARRAQRAQQGLQLQ 392
            LRR  E+   A  Q  EER++  E E A     +L +  +    Q  R A+  QQ +Q +
Sbjct: 1327 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1386

Query: 393  VLR-------LQQDKKQLQEEAARLMRQREELEDKVAACQKEQAD-FLPRIEETKWEVCQ 444
            V+R        QQ K+ +QEE  +L RQ  E E +  A Q E A+    RIEE       
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEE------- 1438

Query: 445  KAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLR-----DSFS 499
               EI +++ QL+ ++        E+  LR++  E  A  R+ +E+   LR     +S  
Sbjct: 1439 ---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495

Query: 500  SKQASLELG---EGELPAACLKP-ALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASL 555
             +QA +EL    + E  AA  K  AL  ++    Q   A     +A++ R   V  A   
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1555

Query: 556  VSVDGEAEAGGESGT---------RALRRE-VGRLQAELAAERRARERQGASFAEE---- 601
                 EAE   +  +         R+L+ E V   Q    AERRA+++  A  A E    
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615

Query: 602  --RRVWLEEKE------KVIEYQKQLQLSYVEMYQRNQQLERRLRERGAA 643
               R  L+  E      +  E  +Q  L+  E  ++ ++ ER  R RG A
Sbjct: 1616 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1665



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 93/382 (24%), Positives = 171/382 (44%), Gaps = 59/382 (15%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQV-------------LEERQKAWERELAELR 368
            Q LEE L   ++E AA  +  ++ EA +A+V              EE  ++   +  +  
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1775

Query: 369  QGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREE-LEDKVAACQ-- 425
            +  +G+ +++A  A R    L+      ++ ++  +E+AAR   + E  L +K+AA    
Sbjct: 1776 EAEAGRFRELAEEAAR----LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1831

Query: 426  ---KEQADFLPRIEETKWEVCQKAGEISL-----LKQQLKDSQADVSQKL--------SE 469
               K +A+   + +E + E  ++  E        L++Q    +AD+ ++L        SE
Sbjct: 1832 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1891

Query: 470  IVGLRSQLREGRASLREKEEQLLSLRDSF---SSKQASLELGEGELPAACLKPALTPVDP 526
            +   +  + +     R+ EE++L+L+ SF   ++ +A LEL  G + +   +  L   + 
Sbjct: 1892 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA-EDTLRSKEQ 1950

Query: 527  AEPQDALAT-CESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELA 585
            AE + A      ++E + RR+A      SL +   E EA  +   +A   EV RL+A++ 
Sbjct: 1951 AELEAARQRQLAAEEERRRREAEERVQKSLAA---EEEAARQR--KAALEEVERLKAKVE 2005

Query: 586  AERRARER---------QGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERR 636
              RR RER         Q A  A ++R+  EEK      Q++ Q    E+ Q  QQ +  
Sbjct: 2006 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ----ELQQTLQQEQSV 2061

Query: 637  LRERGAAGGASTPTPQHGEEKK 658
            L +      A+    +  EE +
Sbjct: 2062 LDQLRGEAEAARRAAEEAEEAR 2083



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 84/370 (22%), Positives = 161/370 (43%), Gaps = 33/370 (8%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGC--SGKLQQVA 379
            QEL++ L +++  +  LR   E +  A  +  E R +A ERE A+ R+    + +L+Q A
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA-EREAAQSRRQVEEAERLKQSA 2107

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
                +A+   Q    +L   +K+ ++EAAR  +  +    +  A   E        E+T 
Sbjct: 2108 EEQAQARAQAQAAAEKL---RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164

Query: 440  WEVCQKAGEISLLKQQLKDSQAD----------VSQKLSEIVGLRSQLREGRASLREKEE 489
             +  Q   E++ L+ QL+++             +  + +E    RSQ+ E   S+R + E
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2224

Query: 490  QLLSLRDSFSSKQASLELGEGELPAACLKPALTPV-DPAEPQDALATCESDEAKMRRQA- 547
            +L  L+    ++  +L L + +     L+     +   AE    L+    + A++R+ A 
Sbjct: 2225 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2284

Query: 548  -GVAAAASLVS--VDGEAEAGGESGTRALRREVGRLQAELAAERRAR-----ERQGASFA 599
              +A   +L    +  + +A  E+       E+ + Q ELA E+  R     E+     A
Sbjct: 2285 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2344

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            EE + +    ++ +E ++Q QL   EM    ++L+ R+ E   A   +    Q   ++  
Sbjct: 2345 EETQGF----QRTLEAERQRQL---EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2397

Query: 660  WTPSRLERIE 669
                +L R E
Sbjct: 2398 EIGEKLHRTE 2407



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 91/369 (24%), Positives = 153/369 (41%), Gaps = 47/369 (12%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            +Q LEE   + E+    LR++  +    V   LE  Q++ E EL   R   + K  Q+ R
Sbjct: 1521 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1580

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLP---RIEE 437
              Q       + V +L+++ ++  ++ A   R REE E ++   Q +  + L    + EE
Sbjct: 1581 SLQEEH----VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1636

Query: 438  TKWEVCQKAGEISLLKQQLK---------DSQADVSQKLSE-IVGLRSQLREGRASLR-E 486
               +      E    K++ +         + QA   ++L+E  +  + QL EG A  R  
Sbjct: 1637 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1696

Query: 487  KEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
             E++L+ LR      +   +L E EL       A    + A         E++ AK+R +
Sbjct: 1697 AEQELIRLRAETEQGEQQRQLLEEEL-------ARLQREAAAATQKRQELEAELAKVRAE 1749

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWL 606
              V   AS    + E+ +  E   + L  E GR +    AE  AR R   + AEE +   
Sbjct: 1750 MEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRE--LAEEAARLR---ALAEEAK--- 1800

Query: 607  EEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGE---EKKAWTPS 663
                      +Q QL+  +  ++  + ER L E+ AA G +T      E   ++K     
Sbjct: 1801 ----------RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1850

Query: 664  RLERIESTE 672
            RL R+   E
Sbjct: 1851 RLRRLAEDE 1859



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 55/370 (14%)

Query: 322  QELEERLWEKEQEVAALRRS----LEQSEAAVAQVLEERQKAWE---RELAELRQGCS-- 372
            + L++R  E++ EV   R      LE+ +A +AQ  + RQ+  E   R+L   R+     
Sbjct: 1147 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1205

Query: 373  GKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFL 432
            G   Q ARR Q   Q + L     Q  ++QL++E A L+ + E   +KV  CQ+    ++
Sbjct: 1206 GAWLQDARRRQEQIQAMPLA--DSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYI 1262

Query: 433  PRIEETKWEVCQKAGEISLLKQQLK------------DSQADVSQKLSEIVGLRSQ-LRE 479
              I++ + ++     ++  +    K                D+    SE+  L SQ ++ 
Sbjct: 1263 NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1322

Query: 480  GRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESD 539
               +LR  EE+     +  + +Q + E        A L+      +      A A  E+ 
Sbjct: 1323 ISETLRRMEEE-----ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1377

Query: 540  EAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFA 599
            E + R Q  V           EA    +   R+++ E+ +L+    AE +A+ RQ A  A
Sbjct: 1378 ELQQRMQEEVVRRE-------EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAA 1429

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            E  R+ +EE+ +V+                  QLE   R+RG A G         EE +A
Sbjct: 1430 ERSRLRIEEEIRVVRL----------------QLEATERQRGGAEGELQALRARAEEAEA 1473

Query: 660  WTPSRLERIE 669
                  E  E
Sbjct: 1474 QKRQAQEEAE 1483



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 87/393 (22%), Positives = 157/393 (39%), Gaps = 44/393 (11%)

Query: 322  QELEERLWEKEQEVA--ALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQ-QV 378
            +E  ER  E+ Q  A  ALR  L+  E A  + L + +   ++E AE      GK + Q 
Sbjct: 1610 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1669

Query: 379  ARRAQRAQQGLQLQV----------LRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQ 428
             R+ + A+Q L+ Q           L  +Q+  +L+ E  +  +QR+ LE+++A  Q+E 
Sbjct: 1670 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1729

Query: 429  ADFLPRIEETKWEVCQKAGEISLL-------KQQLKDSQADVSQKLSEIVGLRSQLREGR 481
            A    + +E + E+ +   E+ +L       +++ + +     Q+L    G   +L E  
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789

Query: 482  ASLR------EKEEQLLSLRDSFSSKQASLELGE-----GELPAACLKPALTPVDPAEPQ 530
            A LR      +++ QL     +    +A   L E     GE      +  +   +     
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849

Query: 531  DALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA 590
            + L     DEA  RR+    AA     ++       ++    L R+ G ++  L   R+ 
Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909

Query: 591  RER---QGASF----AEERRVWLE------EKEKVIEYQKQLQLSYVEMYQRNQQLERRL 637
             E      ASF    A +  + LE        E  +  ++Q +L      Q   + ERR 
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1969

Query: 638  RERGAAGGASTPTPQHGEEKKAWTPSRLERIES 670
            RE       S    +    ++      +ER+++
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEEVERLKA 2002



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 51/347 (14%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAE--LRQGCSG----- 373
            +QE  E++ +  +E A L  S+   EAA  + L E   A +R LAE  L++         
Sbjct: 2252 LQEEAEKMKQVAEEAARL--SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2309

Query: 374  KLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAR------------------LMRQRE 415
            +L+  A   Q+ ++  Q Q  RLQ+DK+Q+ ++ A                   +  + E
Sbjct: 2310 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2369

Query: 416  ELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGL-- 473
             L+ +VA   + QA    R EE      ++A EI    ++L  ++    +K++ +  L  
Sbjct: 2370 RLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEI 2422

Query: 474  -RSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDA 532
             R Q       LRE   +L   ++    +   L+L   E+     +  L      + Q  
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSF 2481

Query: 533  LATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARE 592
            L+  E D    R +      A L  +  +  A  +     LR E  R Q ++  ER   +
Sbjct: 2482 LS--EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ----LREEQQRQQQQMEQER---Q 2532

Query: 593  RQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
            R  AS  E RR   E +E V   Q++LQ    ++ Q+ +Q E  L E
Sbjct: 2533 RLVASMEEARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAE 2575



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 79/340 (23%), Positives = 143/340 (42%), Gaps = 36/340 (10%)

Query: 322  QELEERLWEK---EQEVAALRR-SLEQSEAAVAQV-----LEERQKAWERELAELRQGCS 372
            +E EER+ +    E+E A  R+ +LE+ E   A+V     L ER +       +L Q  +
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029

Query: 373  GKLQQVARRA-----QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE 427
             K  Q   +A     Q+ +Q LQ  + + Q    QL+ EA    R  EE E+     ++E
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2089

Query: 428  QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
             A    ++EE +  + Q A E +  + Q + +   + ++  +    R+Q  +  A+LR+K
Sbjct: 2090 AAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ--AALRQK 2146

Query: 488  EEQLLSL-RDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
            +     + +    ++Q   +  + E     L+  L      E  D       +E +  + 
Sbjct: 2147 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL------EETDHQKNLLDEELQRLKA 2200

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA---RERQGAS-FAEER 602
                AA     V+ E         R    E+ +L+A + AE RA   R++     F +E 
Sbjct: 2201 EATEAARQRSQVEEEL-----FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2255

Query: 603  RVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGA 642
                E+ ++V E   +L ++  E  +  Q  E  L ++ A
Sbjct: 2256 ---AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2292



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 84/323 (26%), Positives = 128/323 (39%), Gaps = 36/323 (11%)

Query: 320  LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
            L+ E  +RL  +  E A  R  +E+   +V   +EE  K   R  AE R         + 
Sbjct: 2190 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR-------ALIL 2242

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
            R     Q+ LQ +  ++    KQ+ EEAARL    +E        +++ A      E+  
Sbjct: 2243 RDKDNTQRFLQEEAEKM----KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2298

Query: 440  WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
             E  Q   E + LK     ++A++ Q+  E+        + R    +KE+    L +   
Sbjct: 2299 KEKMQAVQEATRLK-----AEAELLQQQKELA-----QEQARRLQEDKEQMAQQLAEETQ 2348

Query: 500  SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
              Q +LE           +     +  AE   A A  E D  + R+QA          + 
Sbjct: 2349 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE----KLH 2404

Query: 560  GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
                A  E  T     E+ R Q++  AE R RE    + AE  R    EKEK+ +  K L
Sbjct: 2405 RTELATQEKVTLVQTLEIQRQQSDHDAE-RLRE----AIAELER----EKEKLQQEAKLL 2455

Query: 620  QLSYVEMYQRNQQLERRLRERGA 642
            QL   EM  +  Q E+ L+E  A
Sbjct: 2456 QLKSEEM--QTVQQEQLLQETQA 2476



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 12/172 (6%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            I ELE    + +QE   L+   E+ +    + L +  +A ++     +     + + + +
Sbjct: 2438 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2497

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
               + +Q  Q +V + Q    QL+EE  R  +Q E+   ++ A  +E      R  E + 
Sbjct: 2498 EKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEAR---RRQHEAEE 2550

Query: 441  EVCQKAGEISLLKQQLKDSQ---ADVSQKLSEIVGLRSQLREGRASLREKEE 489
             V +K  E+  L+QQ +  +   A+ +Q+L E + L  +  + RA+L   EE
Sbjct: 2551 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE--QHRAALAHSEE 2600



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 22/116 (18%)

Query: 332  EQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGL-- 389
            EQE A L + L Q E A AQ L E Q+  ++++ + RQ     +++  RR   A++G+  
Sbjct: 2496 EQEKAKLEQ-LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2554

Query: 390  ------QLQVLRLQQDK-------------KQLQEEAARLMRQREELEDKVAACQK 426
                  QL+  R QQ++             + L+E+    +   EE+     A  K
Sbjct: 2555 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2610


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 99/350 (28%), Positives = 150/350 (42%), Gaps = 55/350 (15%)

Query: 338  LRRSLEQSEAAVAQVLEERQKAWERELA-----ELRQGCSGKLQQVARRAQRAQQGLQLQ 392
            LRR  E+   A  Q  EER++  E E A     +L +  +    Q  R A+  QQ +Q +
Sbjct: 1368 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1427

Query: 393  VLR-------LQQDKKQLQEEAARLMRQREELEDKVAACQKEQAD-FLPRIEETKWEVCQ 444
            V+R        QQ K+ +QEE  +L RQ  E E +  A Q E A+    RIEE       
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEE------- 1479

Query: 445  KAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLR-----DSFS 499
               EI +++ QL+ ++        E+  LR++  E  A  R+ +E+   LR     +S  
Sbjct: 1480 ---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536

Query: 500  SKQASLELG---EGELPAACLKP-ALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASL 555
             +QA +EL    + E  AA  K  AL  ++    Q   A     +A++ R   V  A   
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1596

Query: 556  VSVDGEAEAGGESGT---------RALRRE-VGRLQAELAAERRARERQGASFAEE---- 601
                 EAE   +  +         R+L+ E V   Q    AERRA+++  A  A E    
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656

Query: 602  --RRVWLEEKE------KVIEYQKQLQLSYVEMYQRNQQLERRLRERGAA 643
               R  L+  E      +  E  +Q  L+  E  ++ ++ ER  R RG A
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1706



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 93/382 (24%), Positives = 171/382 (44%), Gaps = 59/382 (15%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQV-------------LEERQKAWERELAELR 368
            Q LEE L   ++E AA  +  ++ EA +A+V              EE  ++   +  +  
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1816

Query: 369  QGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREE-LEDKVAACQ-- 425
            +  +G+ +++A  A R    L+      ++ ++  +E+AAR   + E  L +K+AA    
Sbjct: 1817 EAEAGRFRELAEEAAR----LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1872

Query: 426  ---KEQADFLPRIEETKWEVCQKAGEISL-----LKQQLKDSQADVSQKL--------SE 469
               K +A+   + +E + E  ++  E        L++Q    +AD+ ++L        SE
Sbjct: 1873 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1932

Query: 470  IVGLRSQLREGRASLREKEEQLLSLRDSF---SSKQASLELGEGELPAACLKPALTPVDP 526
            +   +  + +     R+ EE++L+L+ SF   ++ +A LEL  G + +   +  L   + 
Sbjct: 1933 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA-EDTLRSKEQ 1991

Query: 527  AEPQDALAT-CESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELA 585
            AE + A      ++E + RR+A      SL +   E EA  +   +A   EV RL+A++ 
Sbjct: 1992 AELEAARQRQLAAEEERRRREAEERVQKSLAA---EEEAARQR--KAALEEVERLKAKVE 2046

Query: 586  AERRARER---------QGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERR 636
              RR RER         Q A  A ++R+  EEK      Q++ Q    E+ Q  QQ +  
Sbjct: 2047 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ----ELQQTLQQEQSV 2102

Query: 637  LRERGAAGGASTPTPQHGEEKK 658
            L +      A+    +  EE +
Sbjct: 2103 LDQLRGEAEAARRAAEEAEEAR 2124



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 84/370 (22%), Positives = 161/370 (43%), Gaps = 33/370 (8%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGC--SGKLQQVA 379
            QEL++ L +++  +  LR   E +  A  +  E R +A ERE A+ R+    + +L+Q A
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA-EREAAQSRRQVEEAERLKQSA 2148

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
                +A+   Q    +L   +K+ ++EAAR  +  +    +  A   E        E+T 
Sbjct: 2149 EEQAQARAQAQAAAEKL---RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205

Query: 440  WEVCQKAGEISLLKQQLKDSQAD----------VSQKLSEIVGLRSQLREGRASLREKEE 489
             +  Q   E++ L+ QL+++             +  + +E    RSQ+ E   S+R + E
Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265

Query: 490  QLLSLRDSFSSKQASLELGEGELPAACLKPALTPV-DPAEPQDALATCESDEAKMRRQA- 547
            +L  L+    ++  +L L + +     L+     +   AE    L+    + A++R+ A 
Sbjct: 2266 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2325

Query: 548  -GVAAAASLVS--VDGEAEAGGESGTRALRREVGRLQAELAAERRAR-----ERQGASFA 599
              +A   +L    +  + +A  E+       E+ + Q ELA E+  R     E+     A
Sbjct: 2326 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2385

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            EE + +    ++ +E ++Q QL   EM    ++L+ R+ E   A   +    Q   ++  
Sbjct: 2386 EETQGF----QRTLEAERQRQL---EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2438

Query: 660  WTPSRLERIE 669
                +L R E
Sbjct: 2439 EIGEKLHRTE 2448



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 91/369 (24%), Positives = 153/369 (41%), Gaps = 47/369 (12%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            +Q LEE   + E+    LR++  +    V   LE  Q++ E EL   R   + K  Q+ R
Sbjct: 1562 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1621

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLP---RIEE 437
              Q       + V +L+++ ++  ++ A   R REE E ++   Q +  + L    + EE
Sbjct: 1622 SLQEEH----VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1677

Query: 438  TKWEVCQKAGEISLLKQQLK---------DSQADVSQKLSE-IVGLRSQLREGRASLR-E 486
               +      E    K++ +         + QA   ++L+E  +  + QL EG A  R  
Sbjct: 1678 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1737

Query: 487  KEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
             E++L+ LR      +   +L E EL       A    + A         E++ AK+R +
Sbjct: 1738 AEQELIRLRAETEQGEQQRQLLEEEL-------ARLQREAAAATQKRQELEAELAKVRAE 1790

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWL 606
              V   AS    + E+ +  E   + L  E GR +    AE  AR R   + AEE +   
Sbjct: 1791 MEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRE--LAEEAARLR---ALAEEAK--- 1841

Query: 607  EEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGE---EKKAWTPS 663
                      +Q QL+  +  ++  + ER L E+ AA G +T      E   ++K     
Sbjct: 1842 ----------RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1891

Query: 664  RLERIESTE 672
            RL R+   E
Sbjct: 1892 RLRRLAEDE 1900



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 55/370 (14%)

Query: 322  QELEERLWEKEQEVAALRRS----LEQSEAAVAQVLEERQKAWE---RELAELRQGCS-- 372
            + L++R  E++ EV   R      LE+ +A +AQ  + RQ+  E   R+L   R+     
Sbjct: 1188 ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1246

Query: 373  GKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFL 432
            G   Q ARR Q   Q + L     Q  ++QL++E A L+ + E   +KV  CQ+    ++
Sbjct: 1247 GAWLQDARRRQEQIQAMPLA--DSQAVREQLRQEQA-LLEEIERHGEKVEECQRFAKQYI 1303

Query: 433  PRIEETKWEVCQKAGEISLLKQQLK------------DSQADVSQKLSEIVGLRSQ-LRE 479
              I++ + ++     ++  +    K                D+    SE+  L SQ ++ 
Sbjct: 1304 NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1363

Query: 480  GRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESD 539
               +LR  EE+     +  + +Q + E        A L+      +      A A  E+ 
Sbjct: 1364 ISETLRRMEEE-----ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1418

Query: 540  EAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFA 599
            E + R Q  V           EA    +   R+++ E+ +L+    AE +A+ RQ A  A
Sbjct: 1419 ELQQRMQEEVVRRE-------EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAA 1470

Query: 600  EERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKA 659
            E  R+ +EE+ +V+                  QLE   R+RG A G         EE +A
Sbjct: 1471 ERSRLRIEEEIRVVRL----------------QLEATERQRGGAEGELQALRARAEEAEA 1514

Query: 660  WTPSRLERIE 669
                  E  E
Sbjct: 1515 QKRQAQEEAE 1524



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 87/393 (22%), Positives = 157/393 (39%), Gaps = 44/393 (11%)

Query: 322  QELEERLWEKEQEVA--ALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQ-QV 378
            +E  ER  E+ Q  A  ALR  L+  E A  + L + +   ++E AE      GK + Q 
Sbjct: 1651 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1710

Query: 379  ARRAQRAQQGLQLQV----------LRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQ 428
             R+ + A+Q L+ Q           L  +Q+  +L+ E  +  +QR+ LE+++A  Q+E 
Sbjct: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1770

Query: 429  ADFLPRIEETKWEVCQKAGEISLL-------KQQLKDSQADVSQKLSEIVGLRSQLREGR 481
            A    + +E + E+ +   E+ +L       +++ + +     Q+L    G   +L E  
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830

Query: 482  ASLR------EKEEQLLSLRDSFSSKQASLELGE-----GELPAACLKPALTPVDPAEPQ 530
            A LR      +++ QL     +    +A   L E     GE      +  +   +     
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890

Query: 531  DALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA 590
            + L     DEA  RR+    AA     ++       ++    L R+ G ++  L   R+ 
Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950

Query: 591  RER---QGASF----AEERRVWLE------EKEKVIEYQKQLQLSYVEMYQRNQQLERRL 637
             E      ASF    A +  + LE        E  +  ++Q +L      Q   + ERR 
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2010

Query: 638  RERGAAGGASTPTPQHGEEKKAWTPSRLERIES 670
            RE       S    +    ++      +ER+++
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKA 2043



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 51/347 (14%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAE--LRQGCSG----- 373
            +QE  E++ +  +E A L  S+   EAA  + L E   A +R LAE  L++         
Sbjct: 2293 LQEEAEKMKQVAEEAARL--SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2350

Query: 374  KLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAR------------------LMRQRE 415
            +L+  A   Q+ ++  Q Q  RLQ+DK+Q+ ++ A                   +  + E
Sbjct: 2351 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410

Query: 416  ELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGL-- 473
             L+ +VA   + QA    R EE      ++A EI    ++L  ++    +K++ +  L  
Sbjct: 2411 RLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEI 2463

Query: 474  -RSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDA 532
             R Q       LRE   +L   ++    +   L+L   E+     +  L      + Q  
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSF 2522

Query: 533  LATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARE 592
            L+  E D    R +      A L  +  +  A  +     LR E  R Q ++  ER   +
Sbjct: 2523 LS--EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ----LREEQQRQQQQMEQER---Q 2573

Query: 593  RQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
            R  AS  E RR   E +E V   Q++LQ    ++ Q+ +Q E  L E
Sbjct: 2574 RLVASMEEARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAE 2616



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 79/340 (23%), Positives = 143/340 (42%), Gaps = 36/340 (10%)

Query: 322  QELEERLWEK---EQEVAALRR-SLEQSEAAVAQV-----LEERQKAWERELAELRQGCS 372
            +E EER+ +    E+E A  R+ +LE+ E   A+V     L ER +       +L Q  +
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070

Query: 373  GKLQQVARRA-----QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE 427
             K  Q   +A     Q+ +Q LQ  + + Q    QL+ EA    R  EE E+     ++E
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2130

Query: 428  QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
             A    ++EE +  + Q A E +  + Q + +   + ++  +    R+Q  +  A+LR+K
Sbjct: 2131 AAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ--AALRQK 2187

Query: 488  EEQLLSL-RDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQ 546
            +     + +    ++Q   +  + E     L+  L      E  D       +E +  + 
Sbjct: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL------EETDHQKNLLDEELQRLKA 2241

Query: 547  AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRA---RERQGAS-FAEER 602
                AA     V+ E         R    E+ +L+A + AE RA   R++     F +E 
Sbjct: 2242 EATEAARQRSQVEEEL-----FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2296

Query: 603  RVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGA 642
                E+ ++V E   +L ++  E  +  Q  E  L ++ A
Sbjct: 2297 ---AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2333



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 84/323 (26%), Positives = 128/323 (39%), Gaps = 36/323 (11%)

Query: 320  LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
            L+ E  +RL  +  E A  R  +E+   +V   +EE  K   R  AE R         + 
Sbjct: 2231 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR-------ALIL 2283

Query: 380  RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
            R     Q+ LQ +  ++    KQ+ EEAARL    +E        +++ A      E+  
Sbjct: 2284 RDKDNTQRFLQEEAEKM----KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2339

Query: 440  WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
             E  Q   E + LK     ++A++ Q+  E+        + R    +KE+    L +   
Sbjct: 2340 KEKMQAVQEATRLK-----AEAELLQQQKELA-----QEQARRLQEDKEQMAQQLAEETQ 2389

Query: 500  SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
              Q +LE           +     +  AE   A A  E D  + R+QA          + 
Sbjct: 2390 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE----KLH 2445

Query: 560  GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
                A  E  T     E+ R Q++  AE R RE    + AE  R    EKEK+ +  K L
Sbjct: 2446 RTELATQEKVTLVQTLEIQRQQSDHDAE-RLRE----AIAELER----EKEKLQQEAKLL 2496

Query: 620  QLSYVEMYQRNQQLERRLRERGA 642
            QL   EM  +  Q E+ L+E  A
Sbjct: 2497 QLKSEEM--QTVQQEQLLQETQA 2517



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/172 (23%), Positives = 79/172 (45%), Gaps = 12/172 (6%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            I ELE    + +QE   L+   E+ +    + L +  +A ++     +     + + + +
Sbjct: 2479 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2538

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
               + +Q  Q +V + Q    QL+EE  R  +Q E+   ++ A  +E      R  E + 
Sbjct: 2539 EKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVASMEEAR---RRQHEAEE 2591

Query: 441  EVCQKAGEISLLKQQLKDSQ---ADVSQKLSEIVGLRSQLREGRASLREKEE 489
             V +K  E+  L+QQ +  +   A+ +Q+L E + L  +  + RA+L   EE
Sbjct: 2592 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE--QHRAALAHSEE 2641



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 22/116 (18%)

Query: 332  EQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGL-- 389
            EQE A L + L Q E A AQ L E Q+  ++++ + RQ     +++  RR   A++G+  
Sbjct: 2537 EQEKAKLEQ-LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2595

Query: 390  ------QLQVLRLQQDK-------------KQLQEEAARLMRQREELEDKVAACQK 426
                  QL+  R QQ++             + L+E+    +   EE+     A  K
Sbjct: 2596 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2651


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 76/332 (22%), Positives = 157/332 (47%), Gaps = 31/332 (9%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            I EL+E   + EQ++  L R + ++   ++Q         E+E+  L+Q    +LQ+   
Sbjct: 1745 IHELQELKDQLEQQLQGLHRKVGETSLLLSQR--------EQEIVVLQQ----QLQEARE 1792

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLP-RIEETK 439
            + +  +Q LQ Q+   Q+   Q  +E   L +++++ + +     KE+AD L   +E+  
Sbjct: 1793 QGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV-KEKADALQGALEQAH 1851

Query: 440  WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
              + ++ GE+   K+Q +  + +++ +   +  L   L + RA  RE+E+ LL+L+   +
Sbjct: 1852 MTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCA 1911

Query: 500  SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
             +    E+    L  + L+      +  +  +AL   ES  ++ + +A  A A +L    
Sbjct: 1912 EQAQEHEVETRALQDSWLQAQAVLKERDQELEAL-RAESQSSRHQEEAARARAEALQEAL 1970

Query: 560  GEAEAGGESG----------TRALRREVGRLQAEL-AAERRARERQGASFAEERRVWLEE 608
            G+A A  +            +R+L      LQA L A +  +R+ + A   +E  +    
Sbjct: 1971 GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEI---- 2026

Query: 609  KEKVIEYQKQLQLSYVEMYQRNQQLERRLRER 640
            +++ + YQ+ +Q     + QR+++L R  +ER
Sbjct: 2027 QDQDLRYQEDVQQLQQALAQRDEEL-RHQQER 2057



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 92/372 (24%), Positives = 161/372 (43%), Gaps = 42/372 (11%)

Query: 323  ELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRA 382
            EL+    + EQE  A  R L Q+E      LE+++ A E+E+ +LR+    +     +  
Sbjct: 814  ELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQEL 873

Query: 383  QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREE--LEDKVAACQ------KEQADFLPR 434
             +A + L+ + + L+   K+ Q E   +  QREE   + + A CQ      KE+   L  
Sbjct: 874  AKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLET 933

Query: 435  IEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVG-LRSQLREGRASLREKEEQ--- 490
            + +T+ E+   + ++  L+Q +K  +     K  E  G L++QL+E +  L+E   Q   
Sbjct: 934  LLQTQKELADASQQLERLRQDMKVQKL----KEQETTGILQTQLQEAQRELKEAARQHRD 989

Query: 491  -LLSLRDSFSS-KQASLELGEGELPAACLKPALTPVDPA------EPQDALATC------ 536
             L +L++  SS  Q  ++L   +     LK  L   D +      E Q+ L         
Sbjct: 990  DLAALQEESSSLLQDKMDL---QKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRI 1046

Query: 537  --ESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQA---ELAAE---- 587
              E +  K      +      + V  EA++  +    ALR+++   Q    EL+A+    
Sbjct: 1047 QKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELL 1106

Query: 588  RRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGAS 647
            R+  + + A F  +    LEE E     ++QL+ S      +  QL+ RLR   +   A 
Sbjct: 1107 RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL 1166

Query: 648  TPTPQHGEEKKA 659
                Q G + +A
Sbjct: 1167 AAEQQPGNQAQA 1178



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 102/408 (25%), Positives = 159/408 (38%), Gaps = 108/408 (26%)

Query: 319  ALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQV 378
            A +Q  E+ L E+    A L RSLE S A +   L+  Q A  R+L E            
Sbjct: 1975 AALQGKEQHLLEQ----AELSRSLEASTATLQASLDACQ-AHSRQLEE------------ 2017

Query: 379  ARRAQRAQQG-LQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEE 437
               A R Q+G +Q Q LR Q+D +QLQ+  A+   + EEL  +    Q  +     R++E
Sbjct: 2018 ---ALRIQEGEIQDQDLRYQEDVQQLQQALAQ---RDEELRHQQEREQLLEKSLAQRVQE 2071

Query: 438  TKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDS 497
               +  Q  G+                ++  EI GL   +RE + +L +KE+++L LR+ 
Sbjct: 2072 NMIQEKQNLGQ---------------EREEEEIRGLHQSVRELQLTLAQKEQEILELRE- 2115

Query: 498  FSSKQASLELGEGELPAACLKPALTPVDPAEP---------QDALATCESDEAKMRRQA- 547
             + ++ +LE        + ++     +D  EP         Q AL   E+ E + R +A 
Sbjct: 2116 -TQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQ 2174

Query: 548  --GVAAAASLVSVDGEAEAGGESGTRALRR--EVGRLQAELAAERRARER---------- 593
               ++ A +  SV    E         L R  E  RLQ EL   RRA E+          
Sbjct: 2175 DLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATS 2234

Query: 594  ---------QGASFAE-------------ERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQ 631
                     QG    E             E++ W +  E + +   +L++    + + N 
Sbjct: 2235 TAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNV 2294

Query: 632  QLERRLRE-------------RGAAGG--------ASTPTPQHGEEKK 658
            QL   L +             R A  G        AS+PT Q G  +K
Sbjct: 2295 QLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQK 2342



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 82/323 (25%), Positives = 140/323 (43%), Gaps = 39/323 (12%)

Query: 319 ALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQV 378
           AL Q L++   E++  +A     L+    ++++  E  QKA E    ELRQ     L+Q 
Sbjct: 432 ALRQRLQKLTGERDT-LAGQTVDLQGEVDSLSKERELLQKARE----ELRQQLE-VLEQE 485

Query: 379 ARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEET 438
           A R +R    LQLQ    Q  K++ QEE    +R+RE L++ +   + +Q++ L      
Sbjct: 486 AWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESL------ 539

Query: 439 KWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSF 498
                    E+  L++ L+ S  +      E+  LR +  E  A+L   E+ +  L  S 
Sbjct: 540 --------SELITLREALESSHLE-----GEL--LRQEQTEVTAALARAEQSIAELSSSE 584

Query: 499 SS-KQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVS 557
           ++ K    +L    +  + L  AL        Q  L   E +++   R      A + + 
Sbjct: 585 NTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQ 644

Query: 558 VDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKE----KVI 613
           VD    A  E    AL  +   L+A+L    +  E  GA    + R   EEKE    K+ 
Sbjct: 645 VD---LAEAEKRREALWEKNTHLEAQL----QKAEEAGAELQADLRDIQEEKEEIQKKLS 697

Query: 614 EYQKQLQLSYVEMYQRNQQLERR 636
           E + Q + +  ++ Q +Q+ +R+
Sbjct: 698 ESRHQQEAATTQLEQLHQEAKRQ 720



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 84/386 (21%), Positives = 155/386 (40%), Gaps = 63/386 (16%)

Query: 271  QDLGTSDSGRASSKSGSSSSMG----RPGHLGSGEGGGGGLPFAACSPPSPSALIQELEE 326
            Q LG+    R     G  S+       P   G+      G    A S  + ++ + +L +
Sbjct: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250

Query: 327  RLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQ 386
             LW+ +Q    LR  +++        LEER    E                    A+++Q
Sbjct: 1251 DLWKTQQTRDVLRDQVQK--------LEERLTDTE--------------------AEKSQ 1282

Query: 387  QGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKA 446
               +LQ   LQ+   Q QEE ++   ++  LE ++    +  A    R+   + +  +  
Sbjct: 1283 VHTELQ--DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ 1340

Query: 447  GEISLLKQQLKDSQADVSQKLSEIVGLRSQ----------LREGRASLREKEEQLLSLRD 496
            GE  LL+   ++  A V    + +V  R+Q          LR  R++L+ K E++ S R+
Sbjct: 1341 GERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE 1400

Query: 497  SFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGV-AAAASL 555
               + Q   EL   +  A     AL     AE ++ + T      ++ +Q  +  AA  L
Sbjct: 1401 RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALEL 1460

Query: 556  VSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEY 615
            +S+D           +   +EV   Q ++    + R     S  E   + ++E+E+ +  
Sbjct: 1461 LSLD----------LKKRNQEVDLQQEQIQELEKCR-----SVLEHLPMAVQEREQKLTV 1505

Query: 616  QKQLQLSYVEMYQRNQQ--LERRLRE 639
            Q++ Q+  +E  +  Q+  LE +L E
Sbjct: 1506 QRE-QIRELEKDRETQRNVLEHQLLE 1530



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 83/346 (23%), Positives = 146/346 (42%), Gaps = 41/346 (11%)

Query: 322  QELEERLWEKEQEVAALR---RSLE-QSEAAVAQVLEERQKAWERELAELRQGCSGKLQQ 377
            Q+L   LW +E + A L+   RS E Q EA  A+     Q   + +LA L       L  
Sbjct: 1136 QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGS 1195

Query: 378  VARRAQRAQQG--LQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRI 435
            V         G      V  L+ D     +  AR + +R  L   ++A  +  A  L ++
Sbjct: 1196 VCESRPELSGGGDSAPSVWGLEPD-----QNGARSLFKRGPLLTALSA--EAVASALHKL 1248

Query: 436  EETKWEVCQK----AGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGR-------ASL 484
             +  W+  Q       ++  L+++L D++A+ SQ  +E+  L+ QL + +          
Sbjct: 1249 HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQ 1308

Query: 485  REKEEQLLSLRDSFSSKQASLE---------LGEGELPAACLKPALTPVDPAEPQDALAT 535
               E +L+ L ++ +S Q+ L           GE EL  A  +     V+  +     A 
Sbjct: 1309 NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEAR 1368

Query: 536  CESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRR--EVGRLQAELAAERRARER 593
             ++  A +  +    A ++L   + E E+  E   +AL+   E+   Q +   E  A   
Sbjct: 1369 AQASAAGILEEDLRTARSALKLKNEEVESERER-AQALQEQGELKVAQGKALQENLALLT 1427

Query: 594  QGASFAEER----RVWLEEKEKVIEYQK-QLQLSYVEMYQRNQQLE 634
            Q  +  EE     R  ++E EK  E QK  L+L  +++ +RNQ+++
Sbjct: 1428 QTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVD 1473



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 69/336 (20%), Positives = 136/336 (40%), Gaps = 65/336 (19%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQ------VLEERQKAWERELAELRQGCSGK 374
            +Q+L++ L ++++E+   +   +  E ++AQ      + E++    ERE  E+R      
Sbjct: 2037 VQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSV 2096

Query: 375  LQQVARRAQRAQQGLQLQVLR----------------LQQDKKQLQEEAARLMRQREELE 418
             +     AQ+ Q+ L+L+  +                +++   +L     RL R+ E L+
Sbjct: 2097 RELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQ 2156

Query: 419  DKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLR 478
              +   +  + ++  + ++    + Q    +S L++     QA V ++ SE   L+ +L 
Sbjct: 2157 AALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELE 2216

Query: 479  EGRASLREKEEQ----LLSLRDSFSSKQASLELGEGELPAACLKP--------------- 519
              R +L EKE        S  +  S  +  ++LGE     A   P               
Sbjct: 2217 LTRRAL-EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHL 2275

Query: 520  ----ALTPVDPAEPQ-------DALATCESDEAKMRRQAGVAAAASLVSV---------- 558
                A   +D +  Q         L   E +  K++R+A  AA A  + +          
Sbjct: 2276 QQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQ 2335

Query: 559  -DGEAEAGGESGTRA-LRREVGRLQAELAAERRARE 592
             DG  +   ++   A L++EV  LQA+L  ER+ ++
Sbjct: 2336 QDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQ 2371



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 69/353 (19%), Positives = 135/353 (38%), Gaps = 40/353 (11%)

Query: 323 ELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQK--AWERELAELRQGCSGKLQQVAR 380
           E+   L   EQ +A L  S    +  VA +     K  A    LA  + G + +L Q+  
Sbjct: 565 EVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEE 624

Query: 381 R----------AQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQ----- 425
                      A++A+  LQ+ +   ++ ++ L E+   L  Q ++ E+  A  Q     
Sbjct: 625 ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD 684

Query: 426 --KEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRAS 483
             +E+ +   ++ E++ +      ++  L Q+ K  +  +++ + E   L  +       
Sbjct: 685 IQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVR 744

Query: 484 LREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCE------ 537
           L+  E     L +      ++ EL E  L  A  + ++  V   + +  + T        
Sbjct: 745 LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804

Query: 538 -----------SDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAA 586
                        E     Q   AAA  L   + E +   E    A  +EV +L+ +   
Sbjct: 805 QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEK 864

Query: 587 ERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
           ER   +++ A   E     LE ++  +E + + Q + +E  Q  ++ ER   E
Sbjct: 865 ERSWHQQELAKALES----LEREKMELEMRLKEQQTEMEAIQAQREEERTQAE 913



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 80/365 (21%), Positives = 150/365 (41%), Gaps = 68/365 (18%)

Query: 330  EKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGL 389
            EKE+    L  S  Q EAA  Q+ +  Q+A  +E    R        Q      R +  L
Sbjct: 688  EKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLAR------AVQEKEALVREKAAL 741

Query: 390  QLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADF----------LPRIEETK 439
            ++++  +++D++ L E+   L   +E LE  +   Q++ +            +  + + K
Sbjct: 742  EVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801

Query: 440  WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQL-REGRASLREK----EEQLLSL 494
             EV Q  GE+  LK +L   ++   Q+        +Q  +EG+ +L ++    E+++  L
Sbjct: 802  -EVIQ--GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQL 858

Query: 495  RDSFSSKQA-----------SLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKM 543
            R+ +  +++           SLE  + EL    LK   T ++  + Q      +++ A  
Sbjct: 859  REKWEKERSWHQQELAKALESLEREKMELEMR-LKEQQTEMEAIQAQREEERTQAESALC 917

Query: 544  RRQ-----AGVAAAASLVSVDGE-AEAG----------------GESGTRALRREVGRLQ 581
            + Q       V+   +L+    E A+A                  +  T  L+ ++   Q
Sbjct: 918  QMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ 977

Query: 582  AELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL-----QLSYVEMYQR--NQQLE 634
             EL    R      A+  EE    L++K   ++ QKQ+     QL   +  QR   Q+++
Sbjct: 978  RELKEAARQHRDDLAALQEESSSLLQDK---MDLQKQVEDLKSQLVAQDDSQRLVEQEVQ 1034

Query: 635  RRLRE 639
             +LRE
Sbjct: 1035 EKLRE 1039



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 93/439 (21%), Positives = 176/439 (40%), Gaps = 107/439 (24%)

Query: 318 SALIQELEERLWEKEQEVAALRRSLE----------QSEAAVAQVLEERQKAWERELAEL 367
           SAL+ + +++  + E+ + ALR ++E          + EA++++  +E + + ++ + ++
Sbjct: 289 SALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDI 348

Query: 368 RQ-------------GCSGKLQ----------------------QVARRAQRAQQGLQLQ 392
            Q             G    L+                       V  R ++A Q L+ Q
Sbjct: 349 TQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQ 408

Query: 393 VLRLQQDKKQLQ------EEAARLMRQR---------------EELEDKVAACQKEQ--- 428
           +   Q+    LQ      EE  + +RQR                +L+ +V +  KE+   
Sbjct: 409 LAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL 468

Query: 429 -------ADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGR 481
                     L  +E+  W + +   E+ L     +  + +  ++L   V  R +L+E  
Sbjct: 469 QKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEML 528

Query: 482 ASLREKE----EQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDP--AEPQDALAT 535
             L  K+     +L++LR++  S        EGEL    L+   T V    A  + ++A 
Sbjct: 529 MGLEAKQSESLSELITLREALESSHL-----EGEL----LRQEQTEVTAALARAEQSIAE 579

Query: 536 CESDEAKMRRQ-AGVAAAASLVSVDGEAEAGGESGTR----ALRREVGRLQAELAAERRA 590
             S E  ++ + A + AAA  +S   EA A  + G       L  E   + + + A  +A
Sbjct: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639

Query: 591 RE--RQGASFAEERRVWLEEKEKVIEYQKQ--------LQLSYVEMYQRNQQLERRLRE- 639
           R   +   + AE+RR  L EK   +E Q Q        LQ    ++ +  ++++++L E 
Sbjct: 640 RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSES 699

Query: 640 RGAAGGASTPTPQHGEEKK 658
           R     A+T   Q  +E K
Sbjct: 700 RHQQEAATTQLEQLHQEAK 718



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 76/335 (22%), Positives = 132/335 (39%), Gaps = 31/335 (9%)

Query: 319 ALIQELEERLWEKEQEVAALRRS--LEQSE-----AAVAQVLEERQKAWE---------R 362
           A  QELE+   E+ QE+  L+    LE++E       ++ +L + QK  E         R
Sbjct: 251 AKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALR 310

Query: 363 ELAELRQGCSGKLQQ----VARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELE 418
           E  E+ +    +L +    ++R AQ  +  LQ  +  + Q   +  +  A+       LE
Sbjct: 311 ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE 370

Query: 419 -DKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQL 477
            D     Q +  D    +   +  + ++   +  L+QQL   Q  V+    +      Q 
Sbjct: 371 LDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ----HDQW 426

Query: 478 REGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCE 537
            E   +LR++ ++L   RD+ + +   L   +GE+ +   +  L      E +  L   E
Sbjct: 427 EEEGKALRQRLQKLTGERDTLAGQTVDL---QGEVDSLSKERELLQKAREELRQQLEVLE 483

Query: 538 SDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGAS 597
            +  ++RR   V       S  G+ E   E    A+ RE  RLQ E+     A++ +  S
Sbjct: 484 QEAWRLRR-VNVELQLQGDSAQGQKEEQQEELHLAV-RERERLQ-EMLMGLEAKQSESLS 540

Query: 598 FAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQ 632
                R  LE      E  +Q Q        R +Q
Sbjct: 541 ELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 37/148 (25%), Positives = 69/148 (46%), Gaps = 17/148 (11%)

Query: 352 VLEERQKAWERELAELRQGCSGKL---QQVARRAQRAQQGLQLQVLR----LQQDKKQLQ 404
           VLEE+  A ++++AE +     KL   Q+  +R     + LQ +VL+     Q+ +K+L+
Sbjct: 19  VLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLE 78

Query: 405 EEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVS 464
                + ++ E +E      +    + L R+EE + + C+   E++  + +L   +ADV 
Sbjct: 79  ATGGPIPQRWENVE------EPNLDELLVRLEEEQ-QRCESLAEVN-TQLRLHMEKADVV 130

Query: 465 QKL--SEIVGLRSQLREGRASLREKEEQ 490
            K    ++  L       R  L  KE Q
Sbjct: 131 NKALREDVEKLTVDWSRARDELMRKESQ 158


>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
           sapiens]
          Length = 1551

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 94/401 (23%), Positives = 159/401 (39%), Gaps = 50/401 (12%)

Query: 290 SMGRPGHL---GSGEGGGGGLPFAAC-------SPPSPSALIQELEERLWEKEQEVAALR 339
           ++  PG L     G   G  LPF          SP S S     LE +L   EQE   L 
Sbjct: 371 TLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELS 430

Query: 340 RSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQD 399
           R  +++  A             REL +LR+    ++Q +  R          ++LR +  
Sbjct: 431 RKHQEALHAPTD---------HRELEQLRK----EVQTLRDRLP--------EMLRDKAS 469

Query: 400 KKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDS 459
             Q     A    Q  +L  ++    +E A+    ++  + E+C+  G+   L Q+L+++
Sbjct: 470 LSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEA 529

Query: 460 QADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKP 519
           Q   +   S+   L SQL E RA+ RE E Q+ SL     S+Q +   G+ E        
Sbjct: 530 QEREAATASQTRALSSQLEEARAAQRELEAQVSSL-----SRQVTQLQGQWEQRLEESSQ 584

Query: 520 ALTPVDPAEPQDALATCES--DEAKMRRQAGVAAAASLVSVDGEAEAGGESG-------T 570
           A T +  A   + +   E    EA++R++   A    L        +G E          
Sbjct: 585 AKT-IHTASETNGMGPPEGGPQEAQLRKEV-AALREQLEQAHSHRPSGKEEALCQLQEEN 642

Query: 571 RALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRN 630
           R L RE  RL+AELA E+ +++R      E    W  +   ++ +    ++S   +    
Sbjct: 643 RRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALA 702

Query: 631 QQLERRLRERGAAGGASTPTPQHGEEKKAWTPSRLERIEST 671
            ++   L      G  + P      +   W   RL+++E++
Sbjct: 703 TKMAEELESLRNVGTQTLPARPLDHQ---WKARRLQKMEAS 740



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 84/339 (24%), Positives = 142/339 (41%), Gaps = 28/339 (8%)

Query: 311 ACSPPSPSALIQELEE---RLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAEL 367
           A SP   S L QEL+     L E    + A  + L +++    ++L+  Q+A ERE A  
Sbjct: 478 AGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATA 537

Query: 368 RQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE 427
            Q  +  L      A+ AQ+ L+ QV  L +   QLQ +  +  R  E  + K      E
Sbjct: 538 SQ--TRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQ--RLEESSQAKTIHTASE 593

Query: 428 QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
                P   E   +  Q   E++ L++QL+ + +       E +    QL+E    L  +
Sbjct: 594 TNGMGP--PEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEAL---CQLQEENRRLSRE 648

Query: 488 EEQLLSLRDSFSSKQASLELGEGELPA------ACLKPALTPVDPAEPQ----DALATCE 537
           +E+L +     + +Q S +  EGE         A L   L+ V+  +       ALAT  
Sbjct: 649 QERLEA---ELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKM 705

Query: 538 SDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGAS 597
           ++E +  R  G     +   +D + +A       A  R    LQ+ L AE RA++     
Sbjct: 706 AEELESLRNVGTQTLPAR-PLDHQWKARRLQKMEASARL--ELQSALEAEIRAKQGLQER 762

Query: 598 FAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERR 636
             + +   L+ + ++ E +KQ Q    E+    ++L  R
Sbjct: 763 LTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRAR 801



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 40/148 (27%), Positives = 58/148 (39%), Gaps = 28/148 (18%)

Query: 340 RSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQD 399
           R L++ EA+      E Q A E E+   +QG   +L QV     +A++       RLQ+ 
Sbjct: 732 RRLQKMEASARL---ELQSALEAEI-RAKQGLQERLTQVQEAQLQAER-------RLQEA 780

Query: 400 KKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDS 459
           +KQ Q     L   REEL  +     K     +P +                 +   KDS
Sbjct: 781 EKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLS---------------FRSSEKDS 825

Query: 460 QAD--VSQKLSEIVGLRSQLREGRASLR 485
             D  +S + +   G      EGR SLR
Sbjct: 826 AKDPGISGEATRHGGEPDLRPEGRRSLR 853


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 64/255 (25%), Positives = 117/255 (45%), Gaps = 30/255 (11%)

Query: 321 IQELEERLWEKEQEVAA--------LRRSLEQSEAAVAQVLEERQKAWE-----RELAEL 367
           IQE EE +W +E+++          + R  ++      ++ E+ ++ W      REL E+
Sbjct: 383 IQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEM 442

Query: 368 RQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREEL--EDKVAACQ 425
            Q    KL++V  + Q  ++ +Q Q  ++Q+ ++++QE+  +  RQ + L  E+K+    
Sbjct: 443 MQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKI---- 498

Query: 426 KEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLR 485
            EQ + + R EE  WE  +K  E     Q+ ++   +   +L +      +++E    L+
Sbjct: 499 WEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQ---QEEKMQEQEVRLQ 555

Query: 486 EKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATC---ESDEAK 542
           E EE+L  L      ++A L  G G    +   P LTP+   E +   A     + D  +
Sbjct: 556 ELEERLGKL-----GQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYR 610

Query: 543 MRRQAGVAAAASLVS 557
              Q  VAA   L S
Sbjct: 611 GHLQQYVAAYQQLAS 625



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 45/324 (13%), Positives = 143/324 (44%), Gaps = 67/324 (20%)

Query: 320 LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
           L Q+ EE++W +E+++      + + E    ++ E+ +K W +E          K+ +  
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQEL---KIREQEEKMWRQE---------EKMHEQE 338

Query: 380 RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
            + +  +  +  Q  ++++ +++++E+  ++ RQ E++ ++    Q+++ +   + E+ +
Sbjct: 339 EKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIR 398

Query: 440 WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
            +  ++  ++   ++++++    + ++  E+     ++RE    ++++EE+L  + +   
Sbjct: 399 EQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQ 458

Query: 500 SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
            ++  +                               +  E K++RQ             
Sbjct: 459 EEEEKM-------------------------------QEQEEKIQRQ------------- 474

Query: 560 GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
                  E   +    +  R +  L  E +  E++   + +E ++W E++EK+ E ++++
Sbjct: 475 -------EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMW-EQEEKMQEQEEKM 526

Query: 620 QLSYVEMYQRNQQL---ERRLRER 640
           Q    +M ++  +L   E +++E+
Sbjct: 527 QRQEEKMREQEVRLWQQEEKMQEQ 550



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 39/198 (19%), Positives = 88/198 (44%), Gaps = 10/198 (5%)

Query: 450 SLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGE 509
           ++  ++LK+  A++ +KL  +   +S+++     L+ K E+   L      +  +  LG+
Sbjct: 210 TITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGK 269

Query: 510 GELPAACLKPALTPVDPAEPQDALATCESD-----EAKMRRQAGVAAAASLVSVDGEAEA 564
            EL +   K     V+  E  + L   + +     E K++ Q        L   + E + 
Sbjct: 270 -ELQSVSAK-LQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKM 327

Query: 565 GGESGTRALRREVGRLQAE--LAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLS 622
             +      + E  R Q +     E + RE++     +E ++W +E EK+ E  +++Q  
Sbjct: 328 WRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQE-EKIREQDEKIQEQ 386

Query: 623 YVEMYQRNQQLERRLRER 640
             EM+++ +++  +  +R
Sbjct: 387 EEEMWRQEEKIREQEEKR 404


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 64/255 (25%), Positives = 117/255 (45%), Gaps = 30/255 (11%)

Query: 321 IQELEERLWEKEQEVAA--------LRRSLEQSEAAVAQVLEERQKAWE-----RELAEL 367
           IQE EE +W +E+++          + R  ++      ++ E+ ++ W      REL E+
Sbjct: 383 IQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEM 442

Query: 368 RQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREEL--EDKVAACQ 425
            Q    KL++V  + Q  ++ +Q Q  ++Q+ ++++QE+  +  RQ + L  E+K+    
Sbjct: 443 MQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKI---- 498

Query: 426 KEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLR 485
            EQ + + R EE  WE  +K  E     Q+ ++   +   +L +      +++E    L+
Sbjct: 499 WEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQ---QEEKMQEQEVRLQ 555

Query: 486 EKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATC---ESDEAK 542
           E EE+L  L      ++A L  G G    +   P LTP+   E +   A     + D  +
Sbjct: 556 ELEERLGKL-----GQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYR 610

Query: 543 MRRQAGVAAAASLVS 557
              Q  VAA   L S
Sbjct: 611 GHLQQYVAAYQQLAS 625



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 45/324 (13%), Positives = 143/324 (44%), Gaps = 67/324 (20%)

Query: 320 LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
           L Q+ EE++W +E+++      + + E    ++ E+ +K W +E          K+ +  
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQEL---KIREQEEKMWRQE---------EKMHEQE 338

Query: 380 RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETK 439
            + +  +  +  Q  ++++ +++++E+  ++ RQ E++ ++    Q+++ +   + E+ +
Sbjct: 339 EKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIR 398

Query: 440 WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
            +  ++  ++   ++++++    + ++  E+     ++RE    ++++EE+L  + +   
Sbjct: 399 EQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQ 458

Query: 500 SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
            ++  +                               +  E K++RQ             
Sbjct: 459 EEEEKM-------------------------------QEQEEKIQRQ------------- 474

Query: 560 GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
                  E   +    +  R +  L  E +  E++   + +E ++W E++EK+ E ++++
Sbjct: 475 -------EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMW-EQEEKMQEQEEKM 526

Query: 620 QLSYVEMYQRNQQL---ERRLRER 640
           Q    +M ++  +L   E +++E+
Sbjct: 527 QRQEEKMREQEVRLWQQEEKMQEQ 550



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 39/198 (19%), Positives = 88/198 (44%), Gaps = 10/198 (5%)

Query: 450 SLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGE 509
           ++  ++LK+  A++ +KL  +   +S+++     L+ K E+   L      +  +  LG+
Sbjct: 210 TITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGK 269

Query: 510 GELPAACLKPALTPVDPAEPQDALATCESD-----EAKMRRQAGVAAAASLVSVDGEAEA 564
            EL +   K     V+  E  + L   + +     E K++ Q        L   + E + 
Sbjct: 270 -ELQSVSAK-LQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKM 327

Query: 565 GGESGTRALRREVGRLQAE--LAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLS 622
             +      + E  R Q +     E + RE++     +E ++W +E EK+ E  +++Q  
Sbjct: 328 WRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQE-EKIREQDEKIQEQ 386

Query: 623 YVEMYQRNQQLERRLRER 640
             EM+++ +++  +  +R
Sbjct: 387 EEEMWRQEEKIREQEEKR 404


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 62/328 (18%), Positives = 150/328 (45%), Gaps = 60/328 (18%)

Query: 320 LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKA----WERELAELRQGCSGKL 375
           L Q+ EE++W +E+++      +++ E  + +  E+ ++     WE+E    RQ     +
Sbjct: 282 LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQ--EEMM 339

Query: 376 QQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQ---KEQADFL 432
            +   + +  ++ +  Q    +Q++K+ +EE  R   +R+E E K+   +   +EQ + +
Sbjct: 340 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 399

Query: 433 PRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLL 492
              EE   E  +K GE    ++++ + + ++ ++  ++     ++RE    +RE+EE++ 
Sbjct: 400 REQEEMMQEQEEKMGE---QEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIR 456

Query: 493 SLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAA 552
              +    ++  +   EG++   C              +  A  +  E KMRRQ      
Sbjct: 457 EQEEMMQEQEEKMGEQEGKM---C--------------EQEAKMQEQEEKMRRQ------ 493

Query: 553 ASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKV 612
                               +R +  +++ +   E + RE++     +E ++W E++EK+
Sbjct: 494 -----------------EEKIREQEKKIREQ---EEKIREQEEMMQEQEEKMW-EQEEKM 532

Query: 613 IEYQKQLQLSYVEMYQRNQQLERRLRER 640
            E ++++Q    E  ++ ++ E ++RE+
Sbjct: 533 CEQEEKMQ----EQEEKMRRQEEKMREQ 556



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 38/173 (21%), Positives = 86/173 (49%), Gaps = 24/173 (13%)

Query: 323 ELEERLWEKEQEVAA----LRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQV 378
           E EE++WE+E+E+      +RR  E+      ++ E+ +K  E+E  E+ Q    K+ + 
Sbjct: 415 EQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE--EMMQEQEEKMGEQ 472

Query: 379 ARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEET 438
             +    +  +Q Q  ++++ +++++E+  ++  Q E++        +EQ + +   EE 
Sbjct: 473 EGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKI--------REQEEMMQEQEEK 524

Query: 439 KWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQL 491
            WE  +K     + +Q+ K  + +   +  E      ++RE    LR++EE++
Sbjct: 525 MWEQEEK-----MCEQEEKMQEQEEKMRRQE-----EKMREQEVRLRQQEEKM 567



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 22/91 (24%), Positives = 52/91 (57%), Gaps = 6/91 (6%)

Query: 319 ALIQELEERLWEKEQEVAALRRSLEQSEAAVAQ----VLEERQKAWERELAELRQGCSGK 374
           A +QE EE++  +E+++    + + + E  + +    + E+ +K WE+E     Q    K
Sbjct: 481 AKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ--EEK 538

Query: 375 LQQVARRAQRAQQGLQLQVLRLQQDKKQLQE 405
           +Q+   + +R ++ ++ Q +RL+Q ++++QE
Sbjct: 539 MQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 65/298 (21%), Positives = 133/298 (44%), Gaps = 29/298 (9%)

Query: 354 EERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQ 413
           E+ QKA  +    LR+    ++Q + R     +  LQ+ +   Q   KQL+ EA  L+ +
Sbjct: 96  EDEQKASHQHQEALRRELEAQVQTI-RILTCQKTELQMALYYSQHAVKQLEGEARDLISR 154

Query: 414 RE-------ELEDKVAAC--QKEQAD-FLPRIEETKWEVCQKAGEISLLKQQLKDSQADV 463
                    ELE  ++A   QK++AD ++  + + +  +  +    ++  ++LK+  A +
Sbjct: 155 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 214

Query: 464 SQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTP 523
            +KL  +   +S+++     L+ K E+   L      +  +  LG+ EL +   K     
Sbjct: 215 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK-ELQSVSAK-LQAQ 272

Query: 524 VDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAE 583
           V+  E  + L   +  E KM RQ            + E +   +      + E  R Q E
Sbjct: 273 VEENELWNRLN--QQQEEKMWRQEEKIQ-------EREEKIQEQEEKIREQEEKMRRQEE 323

Query: 584 LAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL-QLSYVEMYQRNQQLERRLRER 640
           +  E+  + R+     +E  +W E++EK+ E ++++ +   +   +  +Q E ++RE+
Sbjct: 324 MMWEKEEKMRR-----QEEMMW-EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 375


>gi|57864582 hornerin [Homo sapiens]
          Length = 2850

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 86/276 (31%), Positives = 101/276 (36%), Gaps = 56/276 (20%)

Query: 58   RTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVG 117
            R G G  Q S  GP GSGSG S  R G Y S   G  +S  L      S  +   G    
Sbjct: 1953 RHGSGSGQSSSYGPYGSGSGWSSSR-GPYES---GSGHSSGLGHRESRSGQSSGYGQHGS 2008

Query: 118  SSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQN 177
            SSG SS+ G    A                SG+   C +              + H    
Sbjct: 2009 SSGHSSTHGQHGSA----------------SGQSSSCGQHGASSGQ------SSSHGQHG 2046

Query: 178  LCPPQTNGTPEGRQGPG-------GLKGGLDKSRTMTPAGGSGSGLSDS----------- 219
                Q++G   GRQG G       G +G   +        GSGSG S S           
Sbjct: 2047 SGSSQSSGY--GRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGPGLGES 2104

Query: 220  -GRNSLTSLPTYSSSYSQHLAPLSASTS---HINRIGTASYGSGSGGSSGGGSGYQDLG- 274
             G     S    SSSYSQH +    S+    H +R G +S G   G SSG  S Y   G 
Sbjct: 2105 SGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSRYGQHGS 2164

Query: 275  ----TSDSGRASSKSGSSSSMGRPGHLGSGEGGGGG 306
                +S  GR  S SG S S GR G  GSG     G
Sbjct: 2165 GSRQSSGHGRQGSGSGHSPSRGRHGS-GSGHSSSHG 2199



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 80/263 (30%), Positives = 100/263 (38%), Gaps = 56/263 (21%)

Query: 58   RTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVG 117
            R G G  Q S   P GSGSG S  R G Y S                GS H+   G+   
Sbjct: 2423 RHGSGSGQSSSYSPYGSGSGWSSSR-GPYES----------------GSGHSSGLGHRES 2465

Query: 118  SSGGSS------SSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKN 171
             SG SS      SS G      Q+          +TSG+   C +              +
Sbjct: 2466 RSGQSSGYGQHGSSSGHSSTHGQHG---------STSGQSSSCGQHGASSGQ------SS 2510

Query: 172  FHSMQNLCPPQTNGTPEGRQGPG-------GLKGGLDKSRTMTPAGGSGSGLSDSGRNSL 224
             H        Q++G   GRQG G       G +G   +        GSGSG S S     
Sbjct: 2511 SHGQHGSGSSQSSGY--GRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHG 2568

Query: 225  TSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSG-RASS 283
            + L   SS +  H +    S+S+      + +GSGSG SSG G      G S  G R  S
Sbjct: 2569 SGLGE-SSGFGHHESSSGQSSSY------SQHGSGSGHSSGYGQHGSRSGQSSRGERHGS 2621

Query: 284  KSGSSSSMGRPGHLGSGEGGGGG 306
             SGSSS  G+ G  GS +  G G
Sbjct: 2622 SSGSSSHYGQHGS-GSRQSSGHG 2643



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 80/263 (30%), Positives = 100/263 (38%), Gaps = 56/263 (21%)

Query: 58   RTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVG 117
            R G G  Q S  GP  SGSG S  R G Y S                GS H+   G+   
Sbjct: 1013 RHGSGSGQSSSYGPYRSGSGWSSSR-GPYES----------------GSGHSSGLGHRES 1055

Query: 118  SSGGSS------SSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKN 171
             SG SS      SS G      Q+          +TSG+   C +              +
Sbjct: 1056 RSGQSSGYGQHGSSSGHSSTHGQHG---------STSGQSSSCGQHGASSGQ------SS 1100

Query: 172  FHSMQNLCPPQTNGTPEGRQGPG-------GLKGGLDKSRTMTPAGGSGSGLSDSGRNSL 224
             H        Q++G   GRQG G       G +G   +        GSGSG S S     
Sbjct: 1101 SHGQHGSGSSQSSGY--GRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHG 1158

Query: 225  TSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSG-RASS 283
            + L   SS +  H +    S+S+      + +GSGSG SSG G      G S  G R  S
Sbjct: 1159 SGLGE-SSGFGHHESSSGQSSSY------SQHGSGSGHSSGYGQHGSRSGQSSRGERHGS 1211

Query: 284  KSGSSSSMGRPGHLGSGEGGGGG 306
             SGSSS  G+ G  GS +  G G
Sbjct: 1212 SSGSSSHYGQHGS-GSRQSSGHG 1233



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 79/263 (30%), Positives = 99/263 (37%), Gaps = 56/263 (21%)

Query: 58   RTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVG 117
            R G G  Q S   P GSGSG S  R G Y S                GS H+   G+   
Sbjct: 1483 RHGSGSGQSSSYSPYGSGSGWSSSR-GPYES----------------GSSHSSGLGHRES 1525

Query: 118  SSGGSS------SSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKN 171
             SG SS      SS G      Q+          +TSG+   C +              +
Sbjct: 1526 RSGQSSGYGQHGSSSGHSSTHGQHG---------STSGQSSSCGQHGASSGQ------SS 1570

Query: 172  FHSMQNLCPPQTNGTPEGRQGPG-------GLKGGLDKSRTMTPAGGSGSGLSDSGRNSL 224
             H        Q++G   GRQG G       G +G   +        GSGSG S S     
Sbjct: 1571 SHGQHGSGSSQSSGY--GRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHG 1628

Query: 225  TSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSG-RASS 283
            + L   SS +  H +    S+S+      + +GSGSG SSG G      G S  G R  S
Sbjct: 1629 SGLGE-SSGFGHHESSSGQSSSY------SQHGSGSGHSSGYGQHGSRSGQSSRGERHGS 1681

Query: 284  KSGSSSSMGRPGHLGSGEGGGGG 306
             S SSS  G+ G  GS +  G G
Sbjct: 1682 SSRSSSRYGQHGS-GSRQSSGHG 1703



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 76/269 (28%), Positives = 100/269 (37%), Gaps = 44/269 (16%)

Query: 60   GGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVGSS 119
            G G SQ S  G  G+GSG S  R GR+ S                GS H+   G     S
Sbjct: 1340 GSGSSQSSGYGRHGAGSGQSPSR-GRHGS----------------GSGHSSSYGQHGSGS 1382

Query: 120  GGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLC 179
            G SSSSG       Q     H       S    Q        S+++    ++  S +   
Sbjct: 1383 GWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSGQSSRG-- 1440

Query: 180  PPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSDS----------GRNSLTSLPT 229
              + +G+  G     G  G   +        GSGSG S S          G++S  S   
Sbjct: 1441 --ERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYG 1498

Query: 230  YSSSYSQHLAPLSASTSHINRIG------TASYGSGSGGSSGGGSGYQDLGTSDSGRASS 283
              S +S    P  + +SH + +G        S G G  GSS G S       S SG++SS
Sbjct: 1499 SGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSS 1558

Query: 284  ------KSGSSSSMGRPGHLGSGEGGGGG 306
                   SG SSS G+ G  GS +  G G
Sbjct: 1559 CGQHGASSGQSSSHGQHGS-GSSQSSGYG 1586



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 80/290 (27%), Positives = 104/290 (35%), Gaps = 54/290 (18%)

Query: 39   SVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLY 98
            S G   +H Q           G G SQ S  G +GSGSG S  R GR+ S          
Sbjct: 1799 STGQSSSHGQH----------GSGSSQSSSYGQQGSGSGQSPSR-GRHGS---------- 1837

Query: 99   LNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPL 158
                  GS H+   G     SG SSSSG       Q     H       S    Q     
Sbjct: 1838 ------GSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGS 1891

Query: 159  VRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLS- 217
               S+++    ++  S +     + +G+  G     G  G   +        GSGSG S 
Sbjct: 1892 GHSSSYEQHGSRSGQSSRG----EQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSP 1947

Query: 218  -------DSGRNSLTSLPTY--SSSYSQHLAPLSASTSHINRIG------TASYGSGSGG 262
                    SG    +S   Y   S +S    P  + + H + +G        S G G  G
Sbjct: 1948 SPSRGRHGSGSGQSSSYGPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHG 2007

Query: 263  SSGGGSGYQDLGTSDSGRASS------KSGSSSSMGRPGHLGSGEGGGGG 306
            SS G S       S SG++SS       SG SSS G+ G  GS +  G G
Sbjct: 2008 SSSGHSSTHGQHGSASGQSSSCGQHGASSGQSSSHGQHGS-GSSQSSGYG 2056



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 98/325 (30%), Positives = 124/325 (38%), Gaps = 65/325 (20%)

Query: 38  GSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSL 97
           G   S   H       S   + G G SQ S  G +GSGSG S  R GR+ S D G ++S 
Sbjct: 618 GQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSR-GRHGS-DFGHSSSY 675

Query: 98  YLNGELRG-----SDHTDVCGNVVG---------SSG------GSSSSGGSDKAPPQYRE 137
             +G   G       H  V G   G         SSG      GSS S G  K   +  +
Sbjct: 676 GQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQ 735

Query: 138 PSHPPKLLATSG---KLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNG--TPEGRQG 192
            S   +  ++SG      Q      + S        + HS   +    ++G  +  G+ G
Sbjct: 736 SSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRHGSSSGHSSSHGQHG 795

Query: 193 PG--------------GLKGGLDKSRTMTPAG----GSGSG-LSDSGRNSLTSLPT---- 229
            G              G   G  +  + +  G    GS SG  S  GR+  TS  +    
Sbjct: 796 SGTSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASGHFSSQGRHGSTSGQSSSSG 855

Query: 230 -------YSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDS-GRA 281
                   SSSY QH      S SH +  G   +GSGSG S G G      G S S GR 
Sbjct: 856 QHDSSSGQSSSYGQH-----ESASH-HASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRH 909

Query: 282 SSKSGSSSSMGRPGHLGSGEGGGGG 306
            S SG SSS GR G  GSG+  G G
Sbjct: 910 GSGSGRSSSSGRHGS-GSGQSSGFG 933



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 92/314 (29%), Positives = 117/314 (37%), Gaps = 67/314 (21%)

Query: 38   GSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSL 97
            G    G  H       S   + G G  Q S  G +GSGSG S  R GR+ S   GL +S 
Sbjct: 1671 GQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSR-GRHGS---GLGHSS 1726

Query: 98   YLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEP 157
                   GS  +   G     SG SS  G  +         S        SG    CS+ 
Sbjct: 1727 SHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHG-----SGSGHFCSQG 1781

Query: 158  LVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLS 217
                        ++  +          G+  G+    G  G      +     GSGSG S
Sbjct: 1782 ------------QHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQS 1829

Query: 218  DS-GRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGG--------- 267
             S GR+   S   +SSSY QH +    S+S      +  +GSGSG SSG G         
Sbjct: 1830 PSRGRHGSGS--GHSSSYGQHGSGSGWSSS------SGRHGSGSGQSSGFGHHESSSWQS 1881

Query: 268  SGYQDLGT------------SDSGRAS------SKSGSSSSMGRPG-----HLGSGEGGG 304
            SGY   G+            S SG++S      S SGSSSS G+ G      LG G+ G 
Sbjct: 1882 SGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGS 1941

Query: 305  GGLPFAACSPPSPS 318
            G     +   PSPS
Sbjct: 1942 G-----SGQSPSPS 1950



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 95/317 (29%), Positives = 117/317 (36%), Gaps = 73/317 (23%)

Query: 38   GSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSL 97
            G    G  H       S   + G G  Q S  G +GSGSG S  R GR+ S         
Sbjct: 2141 GQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSR-GRHGS--------- 2190

Query: 98   YLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKL---LATSGKLDQC 154
                   GS H+   G     SG SSS G      P      H        + SG     
Sbjct: 2191 -------GSGHSSSHGQHGSGSGRSSSRG------PYESRSGHSSVFGQHESGSGHSSAY 2237

Query: 155  SEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGS 214
            S+       F         S Q+    Q  G+  G+    G  G      +     GSGS
Sbjct: 2238 SQHGSGSGHFCSQGQHGSTSGQSSTFDQ-EGSSTGQSSSHGQHGSGSSQSSSYGQQGSGS 2296

Query: 215  GLSDS-GRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGG------ 267
            G S S GR+   S   +SSSY QH +    S+S      +  +GSGSG SSG G      
Sbjct: 2297 GQSPSRGRHGSGS--GHSSSYGQHGSGSGWSSS------SGRHGSGSGQSSGFGHHESSS 2348

Query: 268  ---SGYQDLGT------------SDSGRAS------SKSGSSSSMGRPG-----HLGSGE 301
               SGY   G+            S SG++S      S SGSSSS G+ G      LG G+
Sbjct: 2349 WQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQ 2408

Query: 302  GGGGGLPFAACSPPSPS 318
             G G     +   PSPS
Sbjct: 2409 HGSG-----SGQSPSPS 2420



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 85/299 (28%), Positives = 110/299 (36%), Gaps = 37/299 (12%)

Query: 38   GSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSL 97
            G    G  H       S   + G G  Q S  G +GSGSG S  R GR+ S   G ++S 
Sbjct: 1201 GQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSR-GRHGS-GLGHSSSH 1258

Query: 98   YLNGELRG-----------SDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLA 146
              +G   G           S H+ V G     SG SS+          +           
Sbjct: 1259 GQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSG 1318

Query: 147  TSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTM 206
             S   DQ      + S++     +   S Q+    + +G   G+    G  G      + 
Sbjct: 1319 QSSTFDQEGSSTGQSSSYGH---RGSGSSQSSGYGR-HGAGSGQSPSRGRHGSGSGHSSS 1374

Query: 207  TPAGGSGSGLSDS-GRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSG 265
                GSGSG S S GR+   S    SS +  H       +S     G   +GSGSG SS 
Sbjct: 1375 YGQHGSGSGWSSSSGRHGSGS--GQSSGFGHH------ESSSWQSSGCTQHGSGSGHSSS 1426

Query: 266  GGSGYQDLGTSDSG-RASSKSGSSSSMGRPG-----HLGSGEGGGGGLPFAACSPPSPS 318
                    G S  G R  S SGSSSS G+ G      LG G+ G G     +   PSPS
Sbjct: 1427 YEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSG-----SGQSPSPS 1480



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 79/287 (27%), Positives = 101/287 (35%), Gaps = 55/287 (19%)

Query: 38   GSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSL 97
            G    G  H       S   + G G  Q S  G +GSGSG S  R GR+ S   GL +S 
Sbjct: 2611 GQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSR-GRHGS---GLGHS- 2665

Query: 98   YLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEP 157
                    S H            GS S   S + P + R        L  S    Q    
Sbjct: 2666 --------SSH---------GQHGSGSGRSSSRGPYESR--------LGHSSVFGQHESG 2700

Query: 158  LVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLS 217
                SA+     ++     + C    +G+  G+      +G      +     GSGS   
Sbjct: 2701 SGHSSAYS----QHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGS--- 2753

Query: 218  DSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSD 277
                       + SS Y +H A    S SH  R G+ S  S S G  G GSG Q  G S 
Sbjct: 2754 -----------SQSSGYGRHGAGSGQSLSH-GRHGSGSGQSSSYGQHGSGSG-QSSGYSQ 2800

Query: 278  SGRASSKSGSSSSMGRPGHLGSGEGGGGGLPFAAC-SPPSPSALIQE 323
             G  S + G S   G   H    +GG  G  F +  S  SP   +QE
Sbjct: 2801 HGSGSGQDGYSYCKGGSNH----DGGSSGSYFLSFPSSTSPYEYVQE 2843



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 83/281 (29%), Positives = 102/281 (36%), Gaps = 67/281 (23%)

Query: 58  RTGGGGSQGSFPGPRGSGSGASRERPGRYPS----------EDKGLANSLYLNGELRGSD 107
           R G G    S  G  GSGS  S  R G Y S           + G   S   +    GS 
Sbjct: 311 RHGSGSGHSSSHGQHGSGSSYSYSR-GHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSG 369

Query: 108 HTDVCGNVVGSSGGSSSSG---GSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAF 164
           H+   G    +SG +SSSG    S +    Y +  H      +SG+    S     P   
Sbjct: 370 HSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQ--HESASRHSSGRGQHSSGSGQSPG-- 425

Query: 165 KPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKG-GLDKSRTMTPAGGSGSGLSDSGRNS 223
                   H  +        G+  G+    G  G G  +S +  P   SGSG S SG   
Sbjct: 426 --------HGQR--------GSGSGQSPSSGQHGTGFGRSSSSGPYV-SGSGYS-SGFGH 467

Query: 224 LTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSG-RAS 282
             S   +SS Y+QH                   GSGSG SSG G      G S  G R  
Sbjct: 468 HESSSEHSSGYTQH-------------------GSGSGHSSGHGQHGSRSGQSSRGERQG 508

Query: 283 SKSGSSSSMGRPG-----HLGSGEGGGGGLPFAACSPPSPS 318
           S +GSSSS G+ G      LG    G G     +   PSPS
Sbjct: 509 SSAGSSSSYGQHGSGSRQSLGHSRHGSG-----SGQSPSPS 544



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 80/301 (26%), Positives = 106/301 (35%), Gaps = 65/301 (21%)

Query: 39   SVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLY 98
            S G   +H Q           G G SQ S  G +GSGSG S  R GR+ S          
Sbjct: 2269 STGQSSSHGQH----------GSGSSQSSSYGQQGSGSGQSPSR-GRHGS---------- 2307

Query: 99   LNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPL 158
                  GS H+   G     SG SSSSG       Q     H       S    Q     
Sbjct: 2308 ------GSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGS 2361

Query: 159  VRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSD 218
               S+++    ++  S +     + +G+  G     G  G   +        GSGSG S 
Sbjct: 2362 GHSSSYEQHGSRSGQSSRG----ERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSP 2417

Query: 219  S----------GRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGT-----------ASYG 257
            S          G++S  S     S +S    P  + + H + +G              +G
Sbjct: 2418 SPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHG 2477

Query: 258  SGSG--------GSSGGGSGYQDLGTSDSGRASSK----SGSSSSMGRPGHLGSGEGGGG 305
            S SG        GS+ G S       + SG++SS     SGSS S G  G  GSG G   
Sbjct: 2478 SSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGY-GRQGSGSGQSP 2536

Query: 306  G 306
            G
Sbjct: 2537 G 2537



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 85/291 (29%), Positives = 113/291 (38%), Gaps = 38/291 (13%)

Query: 38   GSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSL 97
            G  GSG   +  +       R G G  + S  G  GSGSG S    G       G ++  
Sbjct: 894  GQRGSGSGQSPSYG------RHGSGSGRSSSSGRHGSGSGQSS---GFGHKSSSGQSSGY 944

Query: 98   YLNGELRGSDHT---DVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQC 154
              +G   GS H+   +  G+  G S  S   G S  +   Y +     +     G+    
Sbjct: 945  TQHGS--GSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSG 1002

Query: 155  SEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGP----GGLKGGLD--KSRTMTP 208
            S     PS  +        S     P ++       +GP     G   GL   +SR+   
Sbjct: 1003 SGQSPSPSRGRHGSGSGQSSSYG--PYRSGSGWSSSRGPYESGSGHSSGLGHRESRSGQS 1060

Query: 209  AG----GSGSGLSDS-GRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSG-- 261
            +G    GS SG S + G++  TS    SSS  QH A    S+SH      +S  SG G  
Sbjct: 1061 SGYGQHGSSSGHSSTHGQHGSTS--GQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQ 1118

Query: 262  GSSGG---GSGYQDLGTSDS---GRASSKSGSSSSMGRPGHLGSGEGGGGG 306
            GS  G   G G +  G+  S   GR  S SG SSS G+ G  G GE  G G
Sbjct: 1119 GSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGS-GLGESSGFG 1168



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 82/290 (28%), Positives = 107/290 (36%), Gaps = 41/290 (14%)

Query: 38   GSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSL 97
            G   S   H       S   + G G SQ S  G +GSGSG S     R     +  +   
Sbjct: 1554 GQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGR 1613

Query: 98   YLNGELRGS---DHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQC 154
            + +G  R S    H    G   G     SSSG S           H         +  Q 
Sbjct: 1614 HGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQS 1673

Query: 155  SEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAG---- 210
            S      S+ +       H   +    Q++G   GRQG G    G   SR    +G    
Sbjct: 1674 SRGERHGSSSRSSSRYGQHGSGS---RQSSG--HGRQGSG---SGQSPSRGRHGSGLGHS 1725

Query: 211  ------GSGSGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSG--- 261
                  GSGSG S S R    S   +SS + QH +    S+++      + +GSGSG   
Sbjct: 1726 SSHGQHGSGSGRS-SSRGPYESRSGHSSVFGQHESGSGHSSAY------SQHGSGSGHFC 1778

Query: 262  -----GSSGGGSGYQDLGTSDSGRASSK----SGSSSSMGRPGHLGSGEG 302
                 GS+ G S   D   S +G++SS     SGSS S    G  GSG G
Sbjct: 1779 SQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSY-GQQGSGSG 1827



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 88/302 (29%), Positives = 121/302 (40%), Gaps = 48/302 (15%)

Query: 38   GSVGSGVAHAQEFAMKSVGTRT-------GGGGSQGSFPGPRGSGSGASRERPGRYPSED 90
            G  GSG   +     +  G+R        G G  + S  G  GSG G S    G + S  
Sbjct: 1586 GRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGF-GHHESSS 1644

Query: 91   KGLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSS---GGSDKAPPQYREPSHPPKLLAT 147
             G ++S   +G   GS H+   G     SG SS     G S ++  +Y +  H      +
Sbjct: 1645 -GQSSSYSQHGS--GSGHSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQ--HGSGSRQS 1699

Query: 148  SGKLDQCSEPLVRPSAFKP---VVPKNFHSMQNLCPPQTN--GTPEGRQGPGGLKGGLDK 202
            SG   Q S     PS  +    +   + H        +++  G  E R G   + G  + 
Sbjct: 1700 SGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHES 1759

Query: 203  SRTMTPA---GGSGSGL--------SDSGRNSLT----SLPTYSSSYSQHLAPLSASTSH 247
                + A    GSGSG         S SG++S      S    SSS+ QH +  S S+S+
Sbjct: 1760 GSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSY 1819

Query: 248  INRIGTASYGSGSG---GSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLGSGEGGG 304
                G    GSG     G  G GSG+    +S  G+  S SG SSS GR G  GSG+  G
Sbjct: 1820 ----GQQGSGSGQSPSRGRHGSGSGH----SSSYGQHGSGSGWSSSSGRHGS-GSGQSSG 1870

Query: 305  GG 306
             G
Sbjct: 1871 FG 1872



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 86/297 (28%), Positives = 110/297 (37%), Gaps = 38/297 (12%)

Query: 38   GSVGSGVAHAQEFAMKSVGTRT-------GGGGSQGSFPGPRGSGSGASRERPGRYPSED 90
            G  GSG   +     +  G+R        G G  + S  G  GSG G S    G + S  
Sbjct: 1116 GRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGF-GHHESSS 1174

Query: 91   KGLANSLYLNGELRGSDHTDVCGNVVGSSGGSS------SSGGSDKAPPQYREPSHPPKL 144
             G ++S   +G   GS H+   G     SG SS      SS GS     Q+   S     
Sbjct: 1175 -GQSSSYSQHGS--GSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSG 1231

Query: 145  LATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSR 204
                G     S    R  +       +           + G  E R G   + G  +   
Sbjct: 1232 HGRQGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGS 1291

Query: 205  TMTPA---GGSGSGL--------SDSGRNSLT----SLPTYSSSYSQHLAPLSASTSHIN 249
              + A    GSGSG         S SG++S      S    SSSY  H    S+ +S   
Sbjct: 1292 GHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYG-HRGSGSSQSSGYG 1350

Query: 250  RIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLGSGEGGGGG 306
            R G  S  S S G  G GSG+    +S  G+  S SG SSS GR G  GSG+  G G
Sbjct: 1351 RHGAGSGQSPSRGRHGSGSGH----SSSYGQHGSGSGWSSSSGRHGS-GSGQSSGFG 1402



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 81/289 (28%), Positives = 105/289 (36%), Gaps = 35/289 (12%)

Query: 36   AMGSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLAN 95
            A G   S   H       S   + G G SQ S  G +GSGSG S     R     +  + 
Sbjct: 2022 ASGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSY 2081

Query: 96   SLYLNGELRGS---DHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLD 152
              + +G  R S    H    G   G     SSSG S           H         +  
Sbjct: 2082 GRHGSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSG 2141

Query: 153  QCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPG-------GLKGGLDKSRT 205
            Q S      S+         H   +    Q++G   GRQG G       G  G      +
Sbjct: 2142 QSSRGERHGSSSGSSSRYGQHGSGS---RQSSG--HGRQGSGSGHSPSRGRHGSGSGHSS 2196

Query: 206  MTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSG---- 261
                 GSGSG S S R    S   +SS + QH +    S+++      + +GSGSG    
Sbjct: 2197 SHGQHGSGSGRS-SSRGPYESRSGHSSVFGQHESGSGHSSAY------SQHGSGSGHFCS 2249

Query: 262  ----GSSGGGSGYQDLGTSDSGRASSK----SGSSSSMGRPGHLGSGEG 302
                GS+ G S   D   S +G++SS     SGSS S    G  GSG G
Sbjct: 2250 QGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSY-GQQGSGSG 2297



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 85/309 (27%), Positives = 112/309 (36%), Gaps = 49/309 (15%)

Query: 38   GSVGSGVAHAQEFAMKSVGT-------RTGGGGSQGSFPGPRGSGSGASRERPGRYPS-- 88
            G  GSG + +  +  +  G+       + G G  Q    G  GSGSG S       P   
Sbjct: 2043 GQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGPGLG 2102

Query: 89   EDKGLANSLYLNGELR-------GSDHTDVCGNVVGSSGGSS------SSGGSDKAPPQY 135
            E  G  +    +G+         GS H+   G     SG SS      SS GS     Q+
Sbjct: 2103 ESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSRYGQH 2162

Query: 136  REPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGG 195
               S         G     S    R  +       +           + G  E R G   
Sbjct: 2163 GSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSSSHGQHGSGSGRSSSRGPYESRSGHSS 2222

Query: 196  LKGGLDKSRTMTPA---GGSGSGL--------SDSGRNSLT----SLPTYSSSYSQHLAP 240
            + G  +     + A    GSGSG         S SG++S      S    SSS+ QH + 
Sbjct: 2223 VFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSG 2282

Query: 241  LSASTSHINRIGTASYGSGSG---GSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHL 297
             S S+S+    G    GSG     G  G GSG+    +S  G+  S SG SSS GR G  
Sbjct: 2283 SSQSSSY----GQQGSGSGQSPSRGRHGSGSGH----SSSYGQHGSGSGWSSSSGRHGS- 2333

Query: 298  GSGEGGGGG 306
            GSG+  G G
Sbjct: 2334 GSGQSSGFG 2342



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 90/310 (29%), Positives = 120/310 (38%), Gaps = 49/310 (15%)

Query: 38   GSVGSGVAHAQEFAMKSVGT-------RTGGGGSQGSFPGPRGSGSG--ASRERPGRYPS 88
            G  GSG + +  +  +  G+       R G G    S  G  GSGSG  +S  R G    
Sbjct: 2277 GQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 2336

Query: 89   EDKGL----ANSLYLNGELR---GSDHTDVCGNVVGSSGGSS------SSGGSDKAPPQY 135
            +  G     ++S   +G  +   GS H+         SG SS      SS GS  +  Q+
Sbjct: 2337 QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQH 2396

Query: 136  REPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGP-- 193
               S       + G     S     PS  +           +  P  +       +GP  
Sbjct: 2397 GSGSRQ-----SLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYE 2451

Query: 194  --GGLKGGLD--KSRTMTPAG----GSGSGLSDS-GRNSLTSLPTYSSSYSQHLAPLSAS 244
               G   GL   +SR+   +G    GS SG S + G++  TS    SSS  QH A    S
Sbjct: 2452 SGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTS--GQSSSCGQHGASSGQS 2509

Query: 245  TSHINRIGTASYGSGSG--GSSGG---GSGYQDLGTSDS---GRASSKSGSSSSMGRPGH 296
            +SH      +S  SG G  GS  G   G G +  G+  S   GR  S SG SSS G+ G 
Sbjct: 2510 SSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGS 2569

Query: 297  LGSGEGGGGG 306
             G GE  G G
Sbjct: 2570 -GLGESSGFG 2578



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 42/101 (41%), Positives = 50/101 (49%), Gaps = 13/101 (12%)

Query: 211 GSGSGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGY 270
           GSGSG S S  ++  S    SS +SQH +    S+      G + +GSGSG SSG G   
Sbjct: 209 GSGSGQSSSN-DTHGSGSGQSSGFSQHKSSSGQSS------GYSQHGSGSGHSSGYGQHG 261

Query: 271 QDLGTSDSG-RASSKSGSSSSMGRPG-----HLGSGEGGGG 305
              G S  G R  S SGSSSS G+ G      LG G  G G
Sbjct: 262 SRSGQSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSG 302



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 76/276 (27%), Positives = 102/276 (36%), Gaps = 29/276 (10%)

Query: 33  PRLAMGSVGSGVAHAQEFAMKSVG-TRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDK 91
           P ++     SG  H +  +  S G T+ G G    S  G  GS SG S     +  S   
Sbjct: 454 PYVSGSGYSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGS 513

Query: 92  GLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKL 151
             +   + +G  +   H+       GS  G S S    +     R+ S        SG  
Sbjct: 514 SSSYGQHGSGSRQSLGHSRH-----GSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSG-- 566

Query: 152 DQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGG 211
                   R S+  P    + HS         +G   G    G   G    S T    G 
Sbjct: 567 --------RSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSG---HSSTHGQHGS 615

Query: 212 SGSGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQ 271
           +    S  G++  TS    SSS+ QH     + +S  +R G    GSGSG S   G    
Sbjct: 616 TSGQSSSCGQHGATS--GQSSSHGQH----GSGSSQSSRYG--QQGSGSGQSPSRGRHGS 667

Query: 272 DLGTSDS-GRASSKSGSSSSMGRPGHLGSGEGGGGG 306
           D G S S G+  S SG SSS G  G + SG+  G G
Sbjct: 668 DFGHSSSYGQHGSGSGWSSSNGPHGSV-SGQSSGFG 702



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 73/272 (26%), Positives = 93/272 (34%), Gaps = 27/272 (9%)

Query: 60  GGGGSQGSFPGPRGSGSG--ASRERPGRYPSEDKGLANSLYLNGELRG-SDHTDVCGNVV 116
           G G  Q    G  GSGSG  +S +  G    +  G +     +G+  G S H    G+  
Sbjct: 196 GSGSGQSPNYGQHGSGSGQSSSNDTHGSGSGQSSGFSQHKSSSGQSSGYSQHGSGSGHSS 255

Query: 117 GSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQ 176
           G     S SG S +   ++R  S         G   + S    R  +     P +     
Sbjct: 256 GYGQHGSRSGQSSRG-ERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVR--- 311

Query: 177 NLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQ 236
                  +G+  G     G  G             SGSG   SG     S    SS YS+
Sbjct: 312 -------HGSGSGHSSSHGQHGSGSSYSYSRGHYESGSG-QTSGFGQHESGSGQSSGYSK 363

Query: 237 HLAPLSASTS---HINRIGTASYGSGSGGSSGGGSGY---QDLGTSDSGRASSKSGSSSS 290
           H +    S+S   H +  G AS     G SS   S Y   +      SGR    SGS  S
Sbjct: 364 HGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSGSGQS 423

Query: 291 MGRPGHLGSGEG-----GGGGLPFAACSPPSP 317
            G  G  GSG G     G  G  F   S   P
Sbjct: 424 PGH-GQRGSGSGQSPSSGQHGTGFGRSSSSGP 454



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 78/289 (26%), Positives = 110/289 (38%), Gaps = 36/289 (12%)

Query: 46   HAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRG 105
            H     + S   + G G  Q S  G +GSGSG S  R     S   G ++S   +G   G
Sbjct: 742  HGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRHGSSS--GHSSSHGQHGS--G 797

Query: 106  SDHTDVCGNVVGSSGGSSSSGGSDKAPPQ-YREPSHPPKLLATSGKLDQCSEPLVRPSAF 164
            +  +  CG+    SG +S  G  +    Q Y +        ++ G+    S         
Sbjct: 798  TSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASGHFSSQGRHGSTSGQSSSSGQH 857

Query: 165  KPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSDS-GRNS 223
                 ++    Q+      + +  GR G G  +      R      GSGSG S S GR+ 
Sbjct: 858  DSSSGQSSSYGQHESASH-HASGRGRHGSGSGQSPGHGQR------GSGSGQSPSYGRHG 910

Query: 224  LTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSGRAS- 282
              S  + SS      +  S+   H +  G +S  +  G  SG  S Y+  G S SG++S 
Sbjct: 911  SGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHG-SRSGQSSR 969

Query: 283  -----SKSGSSSSMGRPG--------HLGSGEGGGGGLPFAACSPPSPS 318
                 S SGSSSS G+ G        H   G G G          PSPS
Sbjct: 970  SEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSG--------QSPSPS 1010



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 73/265 (27%), Positives = 90/265 (33%), Gaps = 35/265 (13%)

Query: 58   RTGGGGSQGSFPGPRGSGSGAS----RERPGRYPSEDKGLANSLYLNGELRGSDHTDVCG 113
            R G G  Q    G RGSGSG S    R   G   S   G   S   +G+  G  H    G
Sbjct: 882  RHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGRSSSSGRHGSG--SGQSSGFGHKSSSG 939

Query: 114  NVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFH 173
               G +   S SG S              +           S      S  +  +    H
Sbjct: 940  QSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQH 999

Query: 174  SMQNLCPPQTNGTPEGRQGPGG--------LKGGLDKSRTMTPAGGSGSGLSDSGRNSLT 225
               +    Q+     GR G G          + G   S +  P   SGSG S SG     
Sbjct: 1000 GSGS---GQSPSPSRGRHGSGSGQSSSYGPYRSGSGWSSSRGPYE-SGSGHS-SGLGHRE 1054

Query: 226  SLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSK- 284
            S    SS Y QH +    S++H           G  GS+ G S       + SG++SS  
Sbjct: 1055 SRSGQSSGYGQHGSSSGHSSTH-----------GQHGSTSGQSSSCGQHGASSGQSSSHG 1103

Query: 285  ---SGSSSSMGRPGHLGSGEGGGGG 306
               SGSS S G  G  GSG G   G
Sbjct: 1104 QHGSGSSQSSGY-GRQGSGSGQSPG 1127



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 72/261 (27%), Positives = 98/261 (37%), Gaps = 38/261 (14%)

Query: 59  TGGGGSQGSFPGPRGSGSGASRERP------GRYPSEDKGLANSLYLNGELRGSDHTDVC 112
           +G G S G   G RGSGSG S          GR  S    ++ S Y +G       ++  
Sbjct: 418 SGSGQSPGH--GQRGSGSGQSPSSGQHGTGFGRSSSSGPYVSGSGYSSGFGHHESSSEHS 475

Query: 113 GNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNF 172
                   GS  S G  +   +  + S   +  +++G      +     S  +  +  + 
Sbjct: 476 SGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQ---HGSGSRQSLGHSR 532

Query: 173 H---SMQNLCPPQTNGTPEGRQ----GPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLT 225
           H   S Q+  P +       RQ    GP G   G   SR       SGSG S SG     
Sbjct: 533 HGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYE---SGSGHS-SGLGHQE 588

Query: 226 SLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSK- 284
           S    SS Y QH +    S++H           G  GS+ G S       + SG++SS  
Sbjct: 589 SRSGQSSGYGQHGSSSGHSSTH-----------GQHGSTSGQSSSCGQHGATSGQSSSHG 637

Query: 285 ---SGSSSSMGRPGHLGSGEG 302
              SGSS S  R G  GSG G
Sbjct: 638 QHGSGSSQS-SRYGQQGSGSG 657



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 33/88 (37%), Positives = 37/88 (42%), Gaps = 19/88 (21%)

Query: 231 SSSYSQHLAPLSASTSHINRIGTASYGSGSG--------GSSGGGSGYQDLGTSDSGRAS 282
           SSSY +       S SH +  G    GSGSG        GS  G S   D   S SG++S
Sbjct: 176 SSSYGEQ-----NSDSHQSS-GRGQCGSGSGQSPNYGQHGSGSGQSSSNDTHGSGSGQSS 229

Query: 283 S----KSGSSSSMGRPGHLGSGEGGGGG 306
                KS S  S G   H GSG G   G
Sbjct: 230 GFSQHKSSSGQSSGYSQH-GSGSGHSSG 256


>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
          Length = 1478

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 98/409 (23%), Positives = 167/409 (40%), Gaps = 47/409 (11%)

Query: 270  YQDLGTSDSGRASSKSGSSSSMGRPGHLGSGEGGGGGLPFAACSPPSPSALIQELEERLW 329
            YQ L   +S    S +   +      HLG  +     L     +  +  A + E E  L 
Sbjct: 646  YQALQQRESAIQGSLASLEAEQASIRHLG--DQMEASLLAVRKAKEAMKAQMAEKEAILQ 703

Query: 330  EKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQV-ARRAQRAQQG 388
             KE E   LR  +EQ +    Q+ E R     REL  L   C  + Q +    A++ QQG
Sbjct: 704  SKEGECQQLREEVEQCQ----QLAEARH----RELRALESQCQQQTQLIEVLTAEKGQQG 755

Query: 389  -----------LQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEE 437
                       L  Q+   Q   +  Q E  RL  Q  +L+ K+ A   +Q     ++  
Sbjct: 756  VGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSM 815

Query: 438  TKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRAS-LREKEEQLLSLRD 496
             +  + +    +  LK+Q +       Q+L +       L+E RA   +++EE+L +L++
Sbjct: 816  AEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQE 875

Query: 497  SFSSKQASLELGEGELPAACLKPAL----------------TPVDPAEPQDALATC---- 536
              S  + S E  E +L  A L+  L                  V+    ++ALA      
Sbjct: 876  ELSQAKCSSE--EAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQEL 933

Query: 537  -ESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELA-AERRARERQ 594
             ++ EA  R + G+    + +  + E+        +A    +  LQA+LA AE+RA+  Q
Sbjct: 934  QDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQ 993

Query: 595  GASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAA 643
             A+  E   +  +   ++++YQ +L+ +  E      QLE + R+  AA
Sbjct: 994  EAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAA 1042



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 89/372 (23%), Positives = 161/372 (43%), Gaps = 56/372 (15%)

Query: 320 LIQELE---ERLWEKEQEVAALRR--SLEQSEAAVAQVLEERQKAWERELAELRQGCSGK 374
           L QELE   + L +K Q +A+     ++ Q +A  A   + RQ+    + A+  Q    K
Sbjct: 347 LAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEK 406

Query: 375 LQQVARRAQRAQQGLQLQVLRLQQDKKQLQ--EEA----ARLMRQREELEDKVAACQKEQ 428
           LQ + R   + ++  + Q  +L+Q  K+LQ  E+A     RL+++   L+++++   +E 
Sbjct: 407 LQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEA 466

Query: 429 ADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLR---------- 478
                R++E          E++ L+++ K  Q +      E+  L  QL+          
Sbjct: 467 DQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVS 526

Query: 479 EGRASLREKEEQLLSLRDSFSSKQASLELGEG----ELPAACLK-PALTPVD-------- 525
           +  + L E+++QL+  +D  S +   LE   G    ELP A  K  AL PV+        
Sbjct: 527 QHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWG 586

Query: 526 -PAEPQDALATCESDEAKMR--------RQAGVAAAASLVSV-------DGEAEA----- 564
            P E Q  L   + D+ K++        RQA       L +V       +G+ +A     
Sbjct: 587 KPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADY 646

Query: 565 -GGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSY 623
              +    A++  +  L+AE A+ R   ++  AS    R+     K ++ E +  LQ   
Sbjct: 647 QALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKE 706

Query: 624 VEMYQRNQQLER 635
            E  Q  +++E+
Sbjct: 707 GECQQLREEVEQ 718



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 84/357 (23%), Positives = 147/357 (41%), Gaps = 51/357 (14%)

Query: 314 PPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQ---------KAWEREL 364
           P   +  +QEL E+L   E+E   +     Q  A + Q+++E Q         +   +E+
Sbjct: 393 PSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEM 452

Query: 365 AELRQGCSGKLQQVARRAQRAQQGL------QLQVLRLQQDKKQLQEEAARLMRQREELE 418
           A L++  SGK Q+  +  +R Q+ L      + ++  L+++KKQ QEE       +E LE
Sbjct: 453 APLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEE-------KELLE 505

Query: 419 DKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLR 478
            +V +  ++    L  +E    +V Q   ++   K+QL   +  +SQ++  +  L     
Sbjct: 506 QEVRSLTRQ----LQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPG 561

Query: 479 EGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCES 538
                  EK E L+ +  S        E  +  L  A L    T V     ++ L     
Sbjct: 562 PELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDD--TKVQEGSQEEELRQANR 619

Query: 539 D---------------EAKMRR-QAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQA 582
           +               E K++  QA   A     S    + A  E+   ++R    +++A
Sbjct: 620 ELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEA 679

Query: 583 ELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
            L A R+A+E   A  AE+  + L+ KE   +  ++      E+ Q  Q  E R RE
Sbjct: 680 SLLAVRKAKEAMKAQMAEKEAI-LQSKEGECQQLRE------EVEQCQQLAEARHRE 729



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 58/236 (24%), Positives = 103/236 (43%), Gaps = 54/236 (22%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKA---------------WERELAE 366
            Q+ EE L   ++E++  + S E+++   A++ E+  +A                E+E  E
Sbjct: 864  QQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVE 923

Query: 367  LRQGCS-GKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQE--EAAR--------LMRQRE 415
                C+  +LQ     A R ++GL+ QV  LQQ+K+ LQE  +AA+        L  Q  
Sbjct: 924  EALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLA 983

Query: 416  ELEDKVAACQK---------------EQADFLPRIEETKWEVCQKAGEISLLKQQ----- 455
            + E +  + Q+               E  D+  R++    E     G++    +Q     
Sbjct: 984  QAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAE 1043

Query: 456  -----LKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLE 506
                 LK +QAD+ +KLS      + L E +A++  K+++  +LR+     Q  LE
Sbjct: 1044 EAVEKLKATQADMGEKLS---CTSNHLAECQAAMLRKDKEGAALREDLERTQKELE 1096



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 85/365 (23%), Positives = 140/365 (38%), Gaps = 50/365 (13%)

Query: 321 IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERE-------------LAEL 367
           + +LE R  +  + +  L R  ++  AAV+Q  E+ Q   ER              +AEL
Sbjct: 239 LDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAEL 298

Query: 368 RQ--GCSGKLQQVARRAQRAQQGLQLQVLRLQQD----KKQLQEEAARLMRQREELEDKV 421
           ++    +   Q   +  Q   QGL+L     ++D     ++L+     L ++ E   D +
Sbjct: 299 QKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSL 358

Query: 422 AACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGR 481
               +  A F   +   +    QKA   S  K + +   +D +Q++ E+      L   R
Sbjct: 359 DKKNQHLASFPGWLAMAQ----QKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERER 414

Query: 482 ASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEA 541
             + E   Q      S   +Q   EL   E   A L+  +  + P + + +    E+D+ 
Sbjct: 415 TKVEEVNRQ-----QSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQL 469

Query: 542 KMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAE---LAAERRARERQGASF 598
             R Q  +A  +S            E     LRRE  + Q E   L  E R+  RQ   F
Sbjct: 470 WRRLQELLAHTSS-----------WEEELAELRREKKQQQEEKELLEQEVRSLTRQ-LQF 517

Query: 599 AEERRVWLEEKEKVIEYQ-KQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEK 657
            E +   + +    +E Q KQL      + Q+   LER       AG      P  GE+ 
Sbjct: 518 LETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLER------LAGPPGPELPVAGEKN 571

Query: 658 KAWTP 662
           +A  P
Sbjct: 572 EALVP 576



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 28/97 (28%), Positives = 49/97 (50%), Gaps = 3/97 (3%)

Query: 332  EQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQL 391
            E + A LR+  E   AA+ + LE  QK  E+   ++++  +   Q+V  R +R  Q +  
Sbjct: 1069 ECQAAMLRKDKEG--AALREDLERTQKELEKATTKIQEYYNKLCQEVTNR-ERNDQKMLA 1125

Query: 392  QVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQ 428
             +  L + KK L+E    L+R ++ L  K  A + +Q
Sbjct: 1126 DLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQ 1162



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 59/275 (21%), Positives = 109/275 (39%), Gaps = 26/275 (9%)

Query: 389 LQLQVLRLQQDKKQLQEEAARLMRQREEL----------------EDKVAACQKEQADFL 432
           ++L++ +L+  +KQL+E   +L R+ +EL                  + AA    +   L
Sbjct: 235 MRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCL 294

Query: 433 PRIEETKWEVCQKA-GEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQL 491
               + +WEV Q     +  L+  L+  +   ++K  +     + LR   + L+   ++L
Sbjct: 295 VAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEED---YHTALRRLESMLQPLAQEL 351

Query: 492 LSLRDSFSSKQASLELGEGELPAACLK--PALTPVDPAEPQDALATCESDEAKMRRQAGV 549
            + RDS   K   L    G L  A  K   A       EP  + A  E  E   + QA  
Sbjct: 352 EATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALE 411

Query: 550 AAAASLVSVDGEAEAGGESGTRALR-REVGRLQAELAAERRA--RERQGASFAEERRVWL 606
                +  V+ +  A  E   + L+ +E  R   E   +  A  +E       E  ++W 
Sbjct: 412 RERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWR 471

Query: 607 EEKEKVIEYQK-QLQLSYVEMYQRNQQLERRLRER 640
             +E +      + +L+ +   ++ QQ E+ L E+
Sbjct: 472 RLQELLAHTSSWEEELAELRREKKQQQEEKELLEQ 506


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 71/324 (21%), Positives = 144/324 (44%), Gaps = 13/324 (4%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
            + EL++ + +KE++V+ L   L + EAA+ ++  E       E  +L +    +L+  A+
Sbjct: 1394 LDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEII-----EQEDLIKALHTQLEMQAK 1448

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
                  + LQ+++  ++Q  +++ EE+    R +++++ K+ A    + + L   +  + 
Sbjct: 1449 EHDERIKQLQVELCEMKQKPEEIGEES----RAKQQIQRKLQAALISRKEALKENKSLQE 1504

Query: 441  EVCQKAGEISLLKQQLKDSQADVSQKLSE---IVGLRSQLREGRASLREKEEQLLSLRDS 497
            E+    G I  L + L D ++ VS +  E   ++G  + L+E R  L  + ++ L    S
Sbjct: 1505 ELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQS 1564

Query: 498  FSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVS 557
             SS   SL+L    L     K           + A +T   ++ K  ++       S  +
Sbjct: 1565 LSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYEN 1624

Query: 558  VDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQK 617
            V  EAE   +    A+R+E   L  +L +    ++       E  +   E KEK+ ++ K
Sbjct: 1625 VSNEAERI-QHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK 1683

Query: 618  QLQLSYVEMYQRNQQLERRLRERG 641
              Q   +E+ + N +L   +   G
Sbjct: 1684 SKQQKILELEEENDRLRAEVHPAG 1707



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 38/196 (19%), Positives = 95/196 (48%), Gaps = 14/196 (7%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAE----------LRQG 370
            +Q+L+E L     ++AA  +S+   +    +V++E +K WER+ ++          L++ 
Sbjct: 2173 VQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKK-WERKFSDAIQSKEEEIRLKED 2231

Query: 371  CSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQAD 430
                L+   R+     + L++ + RL+ DK+  + +A   ++ ++++ D +   Q E  +
Sbjct: 2232 NCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTL---QGENKE 2288

Query: 431  FLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQ 490
             L ++EET+        E++ L+ +LK  +  ++   + +   + Q       +R++E  
Sbjct: 2289 LLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEAD 2348

Query: 491  LLSLRDSFSSKQASLE 506
            + + + S+   +  L+
Sbjct: 2349 IQNSKFSYEQLETDLQ 2364



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 64/331 (19%), Positives = 133/331 (40%), Gaps = 15/331 (4%)

Query: 312  CSPPSPSAL-IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQG 370
            CS   PSA        + +    E+    + ++Q +  +A + EE+QK   +E ++  + 
Sbjct: 1811 CSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQK--NKEFSQTLEN 1868

Query: 371  CSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQAD 430
                L           + LQ +V ++    +Q+QEE +R+ + +E  E++    ++   +
Sbjct: 1869 EKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMN 1928

Query: 431  FLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQ 490
             L  +  +    CQ   +  +  + L+    ++ + +SE+   + QL      ++EK + 
Sbjct: 1929 QLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQL------VKEKTKV 1982

Query: 491  LLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVA 550
               +R  +  K    +   G    A     L      E +     C   + K+       
Sbjct: 1983 ESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTV 2042

Query: 551  AAASLVSVDG--EAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEE 608
             A   V  +   + E   E+  +A+     + QAELA+ +   +    + +E  RV  + 
Sbjct: 2043 KALEFVQTESQKDLEITKENLAQAVEHR-KKAQAELASFKVLLD---DTQSEAARVLADN 2098

Query: 609  KEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
             +   E Q   +    +M Q+++ LERRL +
Sbjct: 2099 LKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 68/348 (19%), Positives = 155/348 (44%), Gaps = 31/348 (8%)

Query: 323  ELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELR--QGCSGKLQQVAR 380
            +L+E++ ++  E+ +L+    ++E   A+ L+++ ++ + ++A L   +    KL ++ +
Sbjct: 1341 QLQEQINKQGLEIESLKTVSHEAEVH-AESLQQKLESSQLQIAGLEHLRELQPKLDELQK 1399

Query: 381  RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
               + ++ +     +L + +  L +    ++ Q + ++      + +  +   RI++ + 
Sbjct: 1400 LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQV 1459

Query: 441  EVCQ------KAGEISLLKQQL--KDSQADVSQK--LSEIVGLRSQLREGRASLREKEEQ 490
            E+C+      + GE S  KQQ+  K   A +S+K  L E   L+ +L   R ++    + 
Sbjct: 1460 ELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKS 1519

Query: 491  LLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVA 550
            L  +    S++    +   G L  A L+         E +D L T E D + +  Q+  +
Sbjct: 1520 LADVESQVSAQNKEKDTVLGRL--ALLQ---------EERDKLIT-EMDRSLLENQSLSS 1567

Query: 551  AAASL-VSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEK 609
            +  SL ++++G  E         L +E+  L++   AE    + +     +E  + L+  
Sbjct: 1568 SCESLKLALEGLTE-----DKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSY 1622

Query: 610  EKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEK 657
            E V    +++Q     + Q  Q+L  +LR   A    +    Q  E++
Sbjct: 1623 ENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQE 1670



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 70/336 (20%), Positives = 147/336 (43%), Gaps = 39/336 (11%)

Query: 329  WEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRA--- 385
            W    E A    S  Q   +VAQ+ + + K  E E  EL    S    ++ ++++     
Sbjct: 1288 WPSHSEDA----SALQGGTSVAQI-KAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQL 1342

Query: 386  -----QQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
                 +QGL+++ L+    + ++  E+   ++Q+ E      A  +   +  P+++E + 
Sbjct: 1343 QEQINKQGLEIESLKTVSHEAEVHAES---LQQKLESSQLQIAGLEHLRELQPKLDELQK 1399

Query: 441  EVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASL----REKEEQLLSLR- 495
             + +K  ++S L  QL + +A +++  +EI+     ++     L    +E +E++  L+ 
Sbjct: 1400 LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQV 1459

Query: 496  DSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCES--DEAKMRRQAGVAAAA 553
            +    KQ   E+GE       ++  L        ++AL   +S  +E  + R        
Sbjct: 1460 ELCEMKQKPEEIGEESRAKQQIQRKLQAA-LISRKEALKENKSLQEELSLARGTIERLTK 1518

Query: 554  SLVSVDGEAEAGGESGTRALRREVGRLQAE-----LAAERRARERQG-ASFAEERRVWL- 606
            SL  V+ +  A  +     L R +  LQ E        +R   E Q  +S  E  ++ L 
Sbjct: 1519 SLADVESQVSAQNKEKDTVLGR-LALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE 1577

Query: 607  ---EEKEKVIEYQKQLQLSYV----EMYQRNQQLER 635
               E+KEK+++  + L+ S +    E  +++++L++
Sbjct: 1578 GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK 1613



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 75/364 (20%), Positives = 149/364 (40%), Gaps = 40/364 (10%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARR 381
            ++LE  L    +  + L   +   E  +  +L  +++A +  +AELRQ    +++++   
Sbjct: 2357 EQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENL 2416

Query: 382  AQRAQQGLQLQVLRLQQDKKQLQEEAARLM-----------RQREELEDKVAACQKEQAD 430
              + ++    + + L+++ K+  ++  +LM           +Q+ +L+  V +    Q D
Sbjct: 2417 LSQEEE----ENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND 2472

Query: 431  FLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKL-SEIVGLRS---QLREGRASL-- 484
               RI     ++ ++   I L K QL    A  + KL  EI GLRS    L    A L  
Sbjct: 2473 -RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDA 2531

Query: 485  -----REKEEQLLSLRDSFSSKQASLELGEG---ELPAACLKPALTPVDPAEPQDALATC 536
                 RE   Q+++++DS   +   ++L +    E   A L+  L   + A      +  
Sbjct: 2532 ELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN 2591

Query: 537  ESDEAKMRRQAGV-AAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQG 595
               E K      + +   S+  +  +  A  E GT      +G   A+L  +     R  
Sbjct: 2592 ALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT------LGLYHAQLKVKEEEVHRLS 2645

Query: 596  ASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGE 655
            A F+  ++   E +E+++  QK+      E+     +L++ L+      G      +  E
Sbjct: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEI---EDKLKKELKHLHHDAGIMRNETETAE 2702

Query: 656  EKKA 659
            E+ A
Sbjct: 2703 ERVA 2706



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 49/232 (21%), Positives = 95/232 (40%), Gaps = 39/232 (16%)

Query: 315  PSPSALIQELEERLWEKEQEVAALRRS----------------------------LEQSE 346
            P   +  +EL+E L EK+QEV  L++                             LE ++
Sbjct: 2001 PGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITK 2060

Query: 347  AAVAQVLEERQKAWERELAELRQGCSGKLQQVAR-RAQRAQQGLQLQVLRLQQDKKQLQE 405
              +AQ +E R+KA + ELA  +        + AR  A   +   +LQ  + +  K Q+++
Sbjct: 2061 ENLAQAVEHRKKA-QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNK-ESVKSQMKQ 2118

Query: 406  EAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQ 465
            +   L R+ E+ E+K    +K   + L  +   K  + +  GEI +   +       + +
Sbjct: 2119 KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQE 2178

Query: 466  KLSEIVGLRSQLREGRASLREKEEQLL--------SLRDSFSSKQASLELGE 509
             L   V   +   +  +SL++  ++++           D+  SK+  + L E
Sbjct: 2179 NLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKE 2230



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 43/211 (20%), Positives = 103/211 (48%), Gaps = 30/211 (14%)

Query: 324 LEERLWEKEQEVAALRRSLEQSEA--AVAQVLEERQKAWEREL-------------AELR 368
           ++++L EKE+ ++ L+  L Q++A  A  QV+ E+   +E ++             A++ 
Sbjct: 188 MKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVE 247

Query: 369 QGCSGKLQQVARRAQRAQQGL--QLQVLRLQQDKKQLQEEAARLMRQR-EELEDK----- 420
                KL+ + R+ +  ++ L  + QV+ L Q +    E+  +++ Q+ +++E +     
Sbjct: 248 TEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLR 307

Query: 421 -VAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQ---LKDSQADVSQKLSEIVGLRSQ 476
                ++E++  L  +E+ + EV ++      L+++   L +      Q  +E+    S 
Sbjct: 308 NTVETEREESKIL--LEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSA 365

Query: 477 L-REGRASLREKEEQLLSLRDSFSSKQASLE 506
           L ++ +A + EK   +LSL+ +    Q++ +
Sbjct: 366 LEQKHKAEMEEKTSHILSLQKTGQELQSACD 396



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 91/395 (23%), Positives = 164/395 (41%), Gaps = 66/395 (16%)

Query: 324  LEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQ 383
            L++ + EKE E+  +R+ LE+  AA     EE+ +A  +++ +  Q  + ++  +     
Sbjct: 1062 LKQTISEKEVELQHIRKDLEEKLAA-----EEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116

Query: 384  RAQQGLQLQVL----RLQQDKKQLQEEAARLM--------RQREELEDKVAACQKEQADF 431
              Q  +Q  +         D   L +E   +           + ELE+K+ A +KE+   
Sbjct: 1117 ENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQL 1176

Query: 432  LPRIEE---TKWEVCQKAGEISL-----LKQQLKD-----SQADVSQKLSEIVGLRSQLR 478
              +++E   ++  + +KA E        LKQQ  D      Q D   K +E +G   QLR
Sbjct: 1177 QKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIG--DQLR 1234

Query: 479  EGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAA-------CLKPALTPVDPAEPQD 531
            + +  +RE  +  L   D   S  ++  L E    A         L+  L P  P+  +D
Sbjct: 1235 QLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSED 1294

Query: 532  ALATCESDEAKMRRQAGVAAA---ASLVSVDG---EAEAGGESGTRALRR---EVGRLQA 582
            A A           Q G + A   A L  ++    E E    S T  L +   EV +LQ 
Sbjct: 1295 ASAL----------QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQE 1344

Query: 583  ELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQ----QLERRLR 638
            ++  +    E    + + E  V  E  ++ +E   QLQ++ +E  +  Q    +L++ + 
Sbjct: 1345 QINKQGLEIESL-KTVSHEAEVHAESLQQKLE-SSQLQIAGLEHLRELQPKLDELQKLIS 1402

Query: 639  ERGAAGGASTPTPQHGEEKKAWTPSRLERIESTEI 673
            ++      S  + Q  E++ A T  + E IE  ++
Sbjct: 1403 KK--EEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 70/346 (20%), Positives = 133/346 (38%), Gaps = 51/346 (14%)

Query: 326  ERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSG------KLQQVA 379
            E L E ++++     SL+ S+ A +   +E+ K  ++E   L Q          ++Q V 
Sbjct: 1577 EGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVV 1636

Query: 380  RRAQRAQQGLQLQVLRLQQDK----KQLQEEAARLMRQREELEDKVAACQKEQADFLPRI 435
               ++ +Q L  ++   + +K    KQLQE    +   +E++     + Q++  +     
Sbjct: 1637 EAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEN 1696

Query: 436  EETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLR 495
            +  + EV           + L  S A + ++L  +       +    +L +K + L+S +
Sbjct: 1697 DRLRAEVHPAGDTAKECMETLLSSNASMKEELERV-------KMEYETLSKKFQSLMSEK 1749

Query: 496  DSFS--------------SKQASLELGEGELPAACLKPALTPVDP--AEPQDALA----- 534
            DS S              SKQA+LE  E       +    T   P   E QD+L+     
Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRP 1809

Query: 535  TCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAA---ERRAR 591
            TC S+     + A  A +    S D               +++ +L+  +A    E++  
Sbjct: 1810 TC-SESVPSAKSANPAVSKDFSSHD---------EINNYLQQIDQLKERIAGLEEEKQKN 1859

Query: 592  ERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRL 637
            +    +   E+   L +        K LQ    +M   NQQ++  L
Sbjct: 1860 KEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL 1905



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 53/255 (20%), Positives = 100/255 (39%), Gaps = 77/255 (30%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQS-------EAAVAQVLEERQKAWERELAELRQGCSG 373
            +++L ++L  K++++  L   LE S         A+A +  ER   W  EL + R+   G
Sbjct: 2803 LEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWN-ELEKFRKSEEG 2861

Query: 374  KLQQVARRA---------QRAQQGLQLQVLRLQQDKKQLQEEAAR----------LMRQR 414
            K +  A+ +         ++A   LQ    RL ++ K LQ++  +          L  Q 
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQL 2921

Query: 415  EELEDKVAACQKEQADFLP------------RIEETKWEVCQ-------------KAGEI 449
            +E +DK  A Q  Q +               R+E++ WE+ +             K  ++
Sbjct: 2922 QEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQL 2981

Query: 450  SLLKQQLKDSQADVSQK-------------------------LSEIVGLRSQLREGRASL 484
            S L+  +++ ++  SQ                          + E   LR+QL +    +
Sbjct: 2982 SHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEI 3041

Query: 485  REKEEQLLSLRDSFS 499
             +KE ++  L  +FS
Sbjct: 3042 HQKELRIQQLNSNFS 3056



 Score = 37.4 bits (85), Expect = 0.045
 Identities = 64/342 (18%), Positives = 140/342 (40%), Gaps = 30/342 (8%)

Query: 323  ELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRA 382
            ELEE++   E+E   L++ L+++  +   +L++ Q+  ER L E       +L+Q     
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEK-ERHLRE-------ELKQQKDDY 1212

Query: 383  QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQ-REELEDKVAAC-QKEQADFLPRIEETKW 440
             R Q+    Q     ++ + + ++  +L  Q RE ++ K+ +  Q+E     P +EE  +
Sbjct: 1213 NRLQEQFDEQ----SKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLF 1268

Query: 441  EVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSS 500
            +  ++     +L+  L       S+  S + G  + + + +A L+E E + + L    SS
Sbjct: 1269 KATEQHHTQPVLESNLCPDWPSHSEDASALQG-GTSVAQIKAQLKEIEAEKVELELKVSS 1327

Query: 501  KQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVS--V 558
              + L     E            V   + Q      E +  K         A SL     
Sbjct: 1328 TTSELTKKSEE------------VFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375

Query: 559  DGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQ 618
              + +  G    R L+ ++  LQ  ++ +           +E+     + + ++IE +  
Sbjct: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435

Query: 619  LQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQH-GEEKKA 659
            ++  + ++  + ++ + R+++           P+  GEE +A
Sbjct: 1436 IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477



 Score = 37.4 bits (85), Expect = 0.045
 Identities = 48/259 (18%), Positives = 103/259 (39%), Gaps = 37/259 (14%)

Query: 318  SALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQ 377
            SAL    ++R+ E E+E+  +++   +    +   L++  K    +   +R       ++
Sbjct: 2645 SALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEER 2704

Query: 378  VARRAQ-------------RAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAAC 424
            VA  A+             +  +GL  Q+    +    LQ        + +EL+ K  A 
Sbjct: 2705 VAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS 2764

Query: 425  QKEQADFLPR----------IEETKWEVC----QKAGEISLLKQQL--KDSQ-ADVSQKL 467
             KE A    +          + ET + +          +  L QQL  KD Q   +S +L
Sbjct: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824

Query: 468  SEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPA 527
             +         +  ASL+ + + L +  + F   +      EG+  +A  +P+ +P +  
Sbjct: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSE------EGKQRSAA-QPSTSPAEVQ 2877

Query: 528  EPQDALATCESDEAKMRRQ 546
              + A+++ ++D  ++ ++
Sbjct: 2878 SLKKAMSSLQNDRDRLLKE 2896



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 37/151 (24%), Positives = 69/151 (45%), Gaps = 12/151 (7%)

Query: 318 SALIQELEERLWEKEQEV---AALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGK 374
           S LI+ L+ +L  KE EV   A   R +      ++Q L ++    E E+ ++ Q     
Sbjct: 830 STLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQK----ELEITKMDQ----L 881

Query: 375 LQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPR 434
           L +  R  +  QQ ++ +  ++ +    + E+  +L  ++  L  ++    KEQ + L R
Sbjct: 882 LLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTL-KEQLNLLSR 940

Query: 435 IEETKWEVCQKAGEISLLKQQLKDSQADVSQ 465
            EE K E  ++  E+S   +Q  D  +   Q
Sbjct: 941 AEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ 971



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 75/343 (21%), Positives = 137/343 (39%), Gaps = 44/343 (12%)

Query: 318 SALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQ 377
           S L+Q+  E+  +  Q +  L   L+Q    ++Q L  R    + E A            
Sbjct: 403 SKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFL-NRLPLQQHETAS-----QTSFPD 456

Query: 378 VARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADF-LPRIE 436
           V     +A    +  +  LQ+   +L+ E   L+    ELE+  A  +K  +   L   +
Sbjct: 457 VYNEGTQAV--TEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQ 514

Query: 437 ETKWEVCQKAGEISLL------KQQLKDSQADV-----SQKLSEIVGLRSQLREGRASLR 485
               E  ++  EIS++          ++S  DV     SQK  E+  L  +++E +  + 
Sbjct: 515 NRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIA 574

Query: 486 EKEEQLLSLR------DSFSSKQASLELGEGELPAACLKPALT------PVDPAEPQDAL 533
             + QL   R      +    K+     GEG  P   +K  L       P+ P E + +L
Sbjct: 575 FLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIK-MKVFLEDTGQDFPLMPNE-ESSL 632

Query: 534 ATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRR--EVGRL-QAELAAERRA 590
              E ++A    Q+  +   SL     E ++  + G ++L    ++G+  Q EL   +  
Sbjct: 633 PAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQ 692

Query: 591 RERQGASFAEERRVW---LEEKEKVIEYQKQLQLSYVEMYQRN 630
                 +F + + ++   L+EK K I    QL    +E +++N
Sbjct: 693 ILELELNFHKAQEIYEKNLDEKAKEISNLNQL----IEEFKKN 731



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 77/349 (22%), Positives = 141/349 (40%), Gaps = 44/349 (12%)

Query: 321  IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELR-------QGCSG 373
            I+ L   + +   E A L   L Q    + QV+  +    +++L E++       +    
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQ-QKQLLEVQLQQNKELENKYA 2570

Query: 374  KLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKE------ 427
            KL++  + ++ A + L+     LQ++K+ L +E   L     +L  +V A Q+E      
Sbjct: 2571 KLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLY 2630

Query: 428  QADFLPRIEETK-----WEVCQKAGEISLLKQQLKDSQADVSQKLSEIVG-LRSQLRE-- 479
             A    + EE       +   QK   I+ L+++L   Q + ++K+ EI   L+ +L+   
Sbjct: 2631 HAQLKVKEEEVHRLSALFSSSQK--RIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLH 2688

Query: 480  -----GRASLREKEEQLLSL-RDSFSSKQASLEL-GEGELPAACLKPALTPVDPAEPQDA 532
                  R      EE++  L RD    +Q  L +  E +   A ++     +   +    
Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRD 2748

Query: 533  LATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARE 592
             A  E DE K +  A +   A L       E G       L RE   L +E A    + E
Sbjct: 2749 HANEELDELKRKYDASLKELAQL------KEQG------LLNRERDALLSETAFSMNSTE 2796

Query: 593  RQGASFAEE-RRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRER 640
                S  E+  +  L + E+++    QL+ SY ++   ++ +     ER
Sbjct: 2797 ENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER 2845



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 49/207 (23%), Positives = 91/207 (43%), Gaps = 36/207 (17%)

Query: 332 EQEVAALRRSLEQSEAAVAQVLEERQKAWERE-LAELRQGCSG--KLQQVARRAQRAQQG 388
           ++E+  L    EQ+  A A+ LE R  A E++  AE+ +  S    LQ+  +  Q A   
Sbjct: 339 QEEMHHLLEQFEQAGQAQAE-LESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDA 397

Query: 389 LQLQVLRLQQDKK---------------QLQEEAA-------RLMRQREELEDKVA---- 422
           L+ Q  +L QDK                QLQ+++        RL  Q+ E   + +    
Sbjct: 398 LKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDV 457

Query: 423 ---ACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLRE 479
                Q    + +  +++   E+  + G + L   +L++ +A+  +  S+I  L +Q R 
Sbjct: 458 YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517

Query: 480 GRASLREKEEQLLSLRDSFSSKQASLE 506
           G A   ++E   +S+ D  + + +S E
Sbjct: 518 GEA---DREVSEISIVDIANKRSSSAE 541


>gi|4506467 radixin [Homo sapiens]
          Length = 583

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 61/271 (22%), Positives = 114/271 (42%), Gaps = 36/271 (13%)

Query: 321 IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
           +Q+++ +  E++ +    R  LE +E    ++ E+ ++  ERE  EL +    +L+Q+  
Sbjct: 302 VQQMKAQAREEKHQKQLERAQLE-NEKKKREIAEKEKERIEREKEELME----RLKQIEE 356

Query: 381 RAQRAQQGLQLQV---LRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEE 437
           +  +AQ+ L+ Q    L L Q++K+ +EEA RL ++R   E+  +A  K+ AD +   E+
Sbjct: 357 QTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQ 416

Query: 438 TKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDS 497
              E+ +   +I+LL++  K                            +KEE+    +  
Sbjct: 417 LAAELAEFTAKIALLEEAKK----------------------------KKEEEATEWQHK 448

Query: 498 FSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVS 557
             + Q  LE  + EL      P   P  P  P       E DE      A ++    +  
Sbjct: 449 AFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNH 508

Query: 558 VDGEAEAGGESGTRALRREVGRLQAELAAER 588
              E           +++++  L +ELA  R
Sbjct: 509 RSEEERVTETQKNERVKKQLQALSSELAQAR 539



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 33/125 (26%), Positives = 59/125 (47%), Gaps = 8/125 (6%)

Query: 394 LRLQQDKKQLQEEAARLMRQREELED---KVAACQKEQADFLPRIEETKWEVCQKAGEIS 450
           + +QQ K Q +EE  +   +R +LE+   K    +KE+     RIE  K E+ ++  +I 
Sbjct: 300 IEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEK----ERIEREKEELMERLKQIE 355

Query: 451 LLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEG 510
               + +    + ++K  E+   R + +E  A   EKE +      S  +KQA+ ++   
Sbjct: 356 EQTIKAQKELEEQTRKALELDQERKRAKE-EAERLEKERRAAEEAKSAIAKQAADQMKNQ 414

Query: 511 ELPAA 515
           E  AA
Sbjct: 415 EQLAA 419


>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 523

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 93/429 (21%), Positives = 174/429 (40%), Gaps = 65/429 (15%)

Query: 258 SGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLGSGEGGGGGLPFAACSPPSP 317
           +GS   +    GY   G S +G       SS+++         E         A +  S 
Sbjct: 51  NGSSPDTATSGGYHSPGDSATGIYGEGRASSTTL---------EDLESQYQELAVALDSS 101

Query: 318 SALIQELEERL--------WEKEQE---VAALRRSLEQSEAAVAQVLEERQKAWERELAE 366
           SA+I +L E +         EK+ E   V  L RSL + +   A+ L     A   ++ +
Sbjct: 102 SAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQ 161

Query: 367 LRQGCSG---KLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREEL-EDKVA 422
           L+   +    +L+ V R+ Q   +  Q+  L  ++ +++L+E+  RL  Q E L E +  
Sbjct: 162 LQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEER 221

Query: 423 ACQKEQA--DFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREG 480
            C++E+   +   R+ E +  +C++   +   +++L + +  + ++   +     +L E 
Sbjct: 222 LCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQ 281

Query: 481 RASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDE 540
              L E+EE+L    +    ++  L   E  L               E ++ L   E   
Sbjct: 282 EERLCEQEERLREQEERLCEQEERLREQEERL--------------CEQEERLREQEERL 327

Query: 541 AKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAE---LAAERRARERQGAS 597
            +  +  G       V    E E   E   R L RE  RL  E   L  + R R++    
Sbjct: 328 CEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERE--RLLEEVEELLEQERLRQQDERL 385

Query: 598 FAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQ-----------------QLERRLRER 640
           + +E    L+E E++ E ++ L+L +  +Y++                   QLE++++E 
Sbjct: 386 WQQET---LQELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKEL 442

Query: 641 GAAGGASTP 649
             +GGA  P
Sbjct: 443 KKSGGAEEP 451



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 44/201 (21%), Positives = 89/201 (44%), Gaps = 11/201 (5%)

Query: 321 IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
           ++E EERL E+E+ +      L + E  + +  EER +  E  L E  +    + +++  
Sbjct: 271 LREQEERLHEQEERLCEQEERLREQEERLCEQ-EERLREQEERLCEQEERLREQEERLCE 329

Query: 381 RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
           + +   Q   L+ +    ++++ QEE  RL+ +   LE+     ++E+   L + +E  W
Sbjct: 330 QEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEELLEQER---LRQQDERLW 386

Query: 441 --EVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSF 498
             E  Q+   +  L++ L+     + ++ +E      +L     S  + E+Q+  L+   
Sbjct: 387 QQETLQELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELK--- 443

Query: 499 SSKQASLELGEGELPAACLKP 519
             K    E   G   AA  +P
Sbjct: 444 --KSGGAEEPRGSESAAAARP 462


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 88/352 (25%), Positives = 152/352 (43%), Gaps = 46/352 (13%)

Query: 322 QELEERLWEKEQEVAALRRSLEQSEAAVA-----QVLEERQKAWERELAELRQGCSGKLQ 376
           +E+EE L EK   +  L+R LEQ+ A+       +VL++     + EL EL+     + Q
Sbjct: 597 EEMEEELGEK---IEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQ--AERQSQ 651

Query: 377 QVARRAQRAQQGLQLQVLRLQQDK-KQLQEEAARLMRQREEL--------------EDKV 421
           +VA R +  +   QL VLR++ D+ ++L+E+  +L +  ++L              E + 
Sbjct: 652 EVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEA 711

Query: 422 AACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGR 481
               + +A     + ET+ E  +    I  L+QQLK+++  V    +    LR +L+   
Sbjct: 712 TVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLE 771

Query: 482 ASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEA 541
           A  ++ EE L + ++   S  A+    E  L  A    A       + Q  L     +E 
Sbjct: 772 AEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARL----GQEQQTLNRALEEEG 827

Query: 542 KMRR-----QAGVAAAASLVS-----VDGEAEAGGESGTRALRREVGRLQAELAAERRAR 591
           K R      +A +     L+      ++ E E  GE   +AL+    +LQA+L   +   
Sbjct: 828 KQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQ----QLQAQLEDYKEKA 883

Query: 592 ERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAA 643
            R+ A    + + W  E EK      +LQ    E+ +  Q L+    ER  A
Sbjct: 884 RREVADAQRQAKDWASEAEKTSGGLSRLQ---DEIQRLRQALQASQAERDTA 932



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 92/377 (24%), Positives = 162/377 (42%), Gaps = 61/377 (16%)

Query: 322  QELEERL---WEKEQEVAALRRSLE----QSEAAVAQVLEERQ---KAWERELAE---LR 368
            Q+LEE L    E+E  +AA +R+LE    +++  +A++ +E+Q   +A E E  +   LR
Sbjct: 775  QQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 834

Query: 369  QGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQ-LQEEAARLMRQREELEDKVAACQKE 427
            +G   +L++  R   R    L  ++ ++ +D KQ LQ+  A+L   +E+   +VA  Q++
Sbjct: 835  RG-KAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQ 893

Query: 428  QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQA-------DVSQKLSEIVGLRSQLREG 480
              D+    E+T   + +   EI  L+Q L+ SQA       D       + GL  +    
Sbjct: 894  AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENK 953

Query: 481  RASLREKEEQLLSLRDSFSSKQASL--ELGEGELPAACLKPALTPVDP-----AEPQDAL 533
            + S  ++  QL  L +  S  +  L  E    EL    +      VD       + + A 
Sbjct: 954  KRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSAR 1013

Query: 534  ATCESDEAKMRRQ------------AGVAAAASLVSVDGEAEAGGE-------------S 568
               E D+  + RQ                 +ASL  ++ + +   E             S
Sbjct: 1014 QDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQS 1073

Query: 569  GTRALRREVGRLQAELAAERRARERQGASF-----AEERRV--WLEEKEKVIEYQKQLQL 621
              R L R+V  L  ++  ER+    Q         A +R+V    EE E++   +K+ Q 
Sbjct: 1074 TNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQR 1133

Query: 622  SYVEMYQRNQQLERRLR 638
               E ++ N+QL+ R++
Sbjct: 1134 EVEEQHEVNEQLQARIK 1150



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 87/356 (24%), Positives = 159/356 (44%), Gaps = 48/356 (13%)

Query: 322 QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA-- 379
           Q +EE+L  +E+E+ AL+ +L++  A+  Q +E  ++ ++R+  +LR+      Q  A  
Sbjct: 484 QRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVL 543

Query: 380 ----RRAQRAQQGLQLQV--------------LRLQQDKKQLQEEAARLMRQREELE--- 418
               ++     +GLQ ++               + ++D +  ++E  +L  ++EE+E   
Sbjct: 544 EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEEL 603

Query: 419 -DKVAACQKEQADFLPRIEETKW-EVCQKAGEISLLKQQLKDSQADVSQKLSEIVG---- 472
            +K+   Q+E         +T+  EV +K  E+   +++LK+ QA+  ++  E+ G    
Sbjct: 604 GEKIEVLQRELEQARASAGDTRQVEVLKK--ELLRTQEELKELQAE--RQSQEVAGRHRD 659

Query: 473 --LRSQLREGRASL---REKEEQLLSLRDSFSS-KQASLELGEGELPAACLKPALTPVDP 526
             L  QL   R      RE EEQ L L+ +    +Q   E  + ++ A      L     
Sbjct: 660 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRA 719

Query: 527 AEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAA 586
           A       T E ++   RR  G+     L    G  + GGE+    LR ++ RL+AE   
Sbjct: 720 AVETTLRETQEENDEFRRRILGL--EQQLKETRGLVD-GGEAVEARLRDKLQRLEAE--- 773

Query: 587 ERRARERQGASFAEERRVWLEEKEKVIEYQ-KQLQLSYVEMYQRNQQLERRLRERG 641
           +++  E   AS  EE    L   ++ +E + ++ Q     + Q  Q L R L E G
Sbjct: 774 KQQLEEALNASQEEEGS--LAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEG 827



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 83/358 (23%), Positives = 140/358 (39%), Gaps = 61/358 (17%)

Query: 330 EKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQ-- 387
           E  ++V  L+R L++ E    Q LE  Q   ER+L E  + CS   + + RR   AQQ  
Sbjct: 363 ELTRKVEELQRKLDE-EVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSN 421

Query: 388 ------------------GLQLQVLRLQQDKKQLQ-EEAAR------LMRQREELEDKVA 422
                             GL+ QV+ LQ   K +Q  E A+      L+  RE LE+ + 
Sbjct: 422 KELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLE 481

Query: 423 ACQKEQADFLPRIEE-------TKWEVCQKAGEISLLKQ-------QLKDSQADVSQKLS 468
             Q+ +     R  E        K EV  +  E+  ++Q       QL+ S  D +Q   
Sbjct: 482 GKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQ--- 538

Query: 469 EIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAE 528
           +   L ++ ++  A +R  + +L    +     Q+  +  + +L A   +     ++  E
Sbjct: 539 DHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEE 598

Query: 529 PQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQ---AELA 585
            ++ L   E  E   R                 A AG       L++E+ R Q    EL 
Sbjct: 599 MEEELG--EKIEVLQRELE-----------QARASAGDTRQVEVLKKELLRTQEELKELQ 645

Query: 586 AERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAA 643
           AER+++E  G     E    L       +  ++L+   +++ +  QQL +   E   A
Sbjct: 646 AERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKA 703



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 33/175 (18%), Positives = 72/175 (41%), Gaps = 4/175 (2%)

Query: 321  IQELEERLWEKEQEVAAL----RRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQ 376
            +  LE  L E++  V  L     R  +Q +    ++++ER    + E  ++      K  
Sbjct: 971  VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030

Query: 377  QVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIE 436
            +    +    Q     + +L+   + LQE      R++  L+      +++  +   +IE
Sbjct: 1031 KTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIE 1090

Query: 437  ETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQL 491
            + +  V  +  ++SL  + LK    +  +++  + GLR + +       E  EQL
Sbjct: 1091 DERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL 1145



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 39/166 (23%), Positives = 74/166 (44%), Gaps = 19/166 (11%)

Query: 317  PSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQ 376
            PSA + +LE +    ++ +        Q+E     VL+   +  ER++ EL      + Q
Sbjct: 1043 PSASLSQLESQNQLLQERL--------QAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094

Query: 377  QVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARL----MRQREELEDKVAACQKEQADFL 432
             V    Q+ Q  L+++ L+ Q D  + +EE  RL     + + E+E++    ++ QA  +
Sbjct: 1095 HV--NDQKDQLSLRVKALKRQVD--EAEEEIERLDGLRKKAQREVEEQHEVNEQLQAR-I 1149

Query: 433  PRIEETKWEVCQKAGEISLLKQQ--LKDSQADVSQKLSEIVGLRSQ 476
              +E+  W    ++   S LK +    D + D     S I  L ++
Sbjct: 1150 KSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTE 1195


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 68/324 (20%), Positives = 151/324 (46%), Gaps = 33/324 (10%)

Query: 325 EERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWE--RELAELRQGCSGKLQQVARRA 382
           EE +WEKE+++  L   + + E  + + LEE+    E  RE  E RQ      +Q  R+ 
Sbjct: 355 EEMMWEKEEKMRRLEEMMWEKEEKIRE-LEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 413

Query: 383 QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEV 442
           Q A+   Q + +R Q++K  ++E+  ++ RQ E++ ++    ++E+     + +E  W  
Sbjct: 414 QEAKMWRQEEKIREQEEK--IREQEKKMWRQEEKIHEQEKIREEEKR----QEQEEMWRQ 467

Query: 443 CQKAGEIS-LLKQQLKDSQADVSQKLSEIVGLRSQ-LREGRASLREKEEQLLSLRDSFSS 500
            +K  E   + +Q+ K  + +  +K  E V  + + + +    +RE+EE++    +    
Sbjct: 468 EEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIRE 527

Query: 501 KQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDG 560
           ++  +   E ++               E ++ +     ++ KMRRQ              
Sbjct: 528 QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM----QEQEKMRRQE------------- 570

Query: 561 EAEAGGESGTRALRREVGRLQAEL-AAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
           E     E   R  + ++   + ++   E + RE++     +E ++W E++EK+ E ++++
Sbjct: 571 EKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMW-EQEEKMCEQEEKM 629

Query: 620 QLSYVEMYQRNQQL---ERRLRER 640
           Q    +M ++ +++   E RLR++
Sbjct: 630 QEQEEKMRRQEEKMWEQEVRLRQQ 653



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 63/352 (17%), Positives = 155/352 (44%), Gaps = 44/352 (12%)

Query: 320 LIQELEERLWEKEQEVAALRRSLEQSEAAVAQ----VLEERQK-------AWERELAELR 368
           L Q+ EE++W +E+++      +++ E  + +    + E+ +K        WE+E    R
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353

Query: 369 Q-GCSGKLQQVARRAQRAQQGLQLQVLRL-----------QQDKKQLQEEAARLMRQREE 416
           Q     + ++  RR +      + ++  L           +Q++K+ +EE  R   +R+E
Sbjct: 354 QEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 413

Query: 417 LEDKVAACQ---KEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGL 473
            E K+   +   +EQ + +   E+  W   +K  E   ++++ K  + +   +  E +  
Sbjct: 414 QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 473

Query: 474 RSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDAL 533
           + ++   +  + E +E++    +    ++  +   E ++     K         E ++ +
Sbjct: 474 QEEIWRQKEKMHE-QEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKI 532

Query: 534 ATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAER--RAR 591
                 E K+R Q  +        +  + E  GE   +   +E  R Q E   E+  + R
Sbjct: 533 ---REQEEKIREQEEM--------MQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIR 581

Query: 592 ERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQL---ERRLRER 640
           E++     +E ++W E++EK+ E ++ +Q    +M+++ +++   E +++E+
Sbjct: 582 EQKEKIREQEEKIW-EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 632



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 68/365 (18%), Positives = 156/365 (42%), Gaps = 46/365 (12%)

Query: 321 IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA- 379
           +Q +E    E +  V  L+R LE+++  + Q   ++ +A    L +  Q  S KLQ    
Sbjct: 230 LQLVESEKSEIQLNVKELKRKLERAKLLLPQ---QQLQAEADHLGKELQSVSAKLQAQVE 286

Query: 380 ------RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQK------E 427
                 R  Q+ ++ +  Q  ++Q+ ++++QE+  ++  Q E++ ++    ++      E
Sbjct: 287 ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE 346

Query: 428 QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK 487
           + + + R EE  WE  +K   +  +  + ++   ++ +K+ E   +R Q        + +
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQ------EEKRQ 400

Query: 488 EEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQA 547
           EE+ +  ++    ++A +   E ++               E ++ +      E KM RQ 
Sbjct: 401 EEEKIREQEKRQEQEAKMWRQEEKI--------------REQEEKI---REQEKKMWRQE 443

Query: 548 GVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLE 607
                   +    E E   E      + E  R Q E+  ++     Q     +E +VW +
Sbjct: 444 EKIHEQEKIR---EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQ 500

Query: 608 EKEKVIEYQKQLQLSYVEMYQRNQQL---ERRLRERGAAGGASTPTPQHGEEKKAWTPSR 664
           E EK+ + +++++    +M+++ +++   E ++RE+           Q  EEK      +
Sbjct: 501 E-EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559

Query: 665 LERIE 669
           ++  E
Sbjct: 560 MQEQE 564



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 41/198 (20%), Positives = 94/198 (47%), Gaps = 23/198 (11%)

Query: 321 IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
           I++ EE++W +E+++       +Q E    ++ E+ +K W +E  ++R+      Q+   
Sbjct: 490 IRKQEEKVWRQEEKMH------DQEE----KIREQEEKMWRQE-EKIRE------QEEKI 532

Query: 381 RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQ---KEQADFLPRIEE 437
           R Q  +   Q ++++ Q++K   QEE  +   +    E+K+   +   +EQ + +   EE
Sbjct: 533 REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEE 592

Query: 438 TKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDS 497
             WE  +K  E   + Q+ ++   +  +K+ E      +++E    +R +EE++      
Sbjct: 593 KIWEQEEKIREQEEMMQEQEEKMWEQEEKMCE---QEEKMQEQEEKMRRQEEKMWEQEVR 649

Query: 498 FSSKQASLELGEGELPAA 515
              ++  ++  +  L AA
Sbjct: 650 LRQQEEKMQEHQEHLEAA 667



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 25/115 (21%), Positives = 58/115 (50%), Gaps = 15/115 (13%)

Query: 320 LIQELEERLWEKEQEVAALRRSLEQSEAAVAQ----------VLEERQKAWE-----REL 364
           ++QE EE++ E+E+++    +   Q E    Q          + E+ +K WE     RE 
Sbjct: 545 MMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQ 604

Query: 365 AELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELED 419
            E+ Q    K+ +   +    ++ +Q Q  ++++ ++++ E+  RL +Q E++++
Sbjct: 605 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 65/297 (21%), Positives = 129/297 (43%), Gaps = 25/297 (8%)

Query: 354 EERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQ 413
           E+ QKA  +    LR+    ++  + R     +  LQ+ +   Q   KQL+ EA  L+ +
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTI-RILTCQKTELQMALYYSQHAVKQLEGEARDLISR 166

Query: 414 RE-------ELEDKVAAC--QKEQAD-FLPRIEETKWEVCQKAGEISLLKQQLKDSQADV 463
                    ELE  ++A   QK++AD ++  + + +  +  +    ++  ++LK+  A +
Sbjct: 167 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 226

Query: 464 SQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTP 523
            +KL  +   +S+++     L+ K E+   L      +  +  LG+ EL +   K     
Sbjct: 227 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK-ELQSVSAK-LQAQ 284

Query: 524 VDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAE 583
           V+  E  + L   +  E KM RQ            + E +   +      + E  R Q E
Sbjct: 285 VEENELWNRLN--QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE 342

Query: 584 LAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRER 640
           +  E+  + R+     +E  +W  EKE   E  ++L+    E  ++ ++LE ++ E+
Sbjct: 343 MMWEKEEKMRR-----QEEMMW--EKE---EKMRRLEEMMWEKEEKIRELEEKMHEQ 389



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 17/74 (22%), Positives = 40/74 (54%), Gaps = 12/74 (16%)

Query: 320 LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
           ++QE EE++WE+E+++      +++ E    ++  + +K WE+E+         +L+Q  
Sbjct: 607 MMQEQEEKMWEQEEKMCEQEEKMQEQE---EKMRRQEEKMWEQEV---------RLRQQE 654

Query: 380 RRAQRAQQGLQLQV 393
            + Q  Q+ L+  +
Sbjct: 655 EKMQEHQEHLEAAI 668


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 66/324 (20%), Positives = 151/324 (46%), Gaps = 38/324 (11%)

Query: 325 EERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWE--RELAELRQGCSGKLQQVARRA 382
           EE +WEKE+++      + + E  + + LEE+    E  RE  E RQ      +Q  R+ 
Sbjct: 416 EEMMWEKEEKMRRQEEMMWEKEEKIRE-LEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 474

Query: 383 QRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW-- 440
           Q A+   Q + +R Q++K + QEE  ++ RQ E++ ++    ++E+     + +E  W  
Sbjct: 475 QEAKMWRQEEKIREQEEKIREQEE--KMWRQEEKIHEQEKIREEEKR----QEQEEMWRQ 528

Query: 441 -EVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFS 499
            E  ++  EI   K+++ + +  + ++  ++     ++ +    +RE+EE++    +   
Sbjct: 529 EEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR 588

Query: 500 SKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVD 559
            ++  +   E ++               E ++ +  CE +E KM+ Q             
Sbjct: 589 EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM--CEQEE-KMQEQ------------- 632

Query: 560 GEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQL 619
              E         +R +  +++ +   E + RE++     +E ++W E++EK+ E ++++
Sbjct: 633 ---EEKMRRQEEKIREQEKKIREQ---EEKIREQEEMMQEQEEKMW-EQEEKMCEQEEKM 685

Query: 620 QLSYVEMYQRNQQL---ERRLRER 640
           Q    +M ++ +++   E RLR++
Sbjct: 686 QEQEEKMRRQEEKMWEQEVRLRQQ 709



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 31/145 (21%), Positives = 75/145 (51%), Gaps = 13/145 (8%)

Query: 321 IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGC--SGKLQQV 378
           I+E EE++W +E+++      + + E  + +  E  Q+  E+   +  + C    K+Q+ 
Sbjct: 573 IREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 632

Query: 379 ARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREEL-EDKVAACQ-----KEQADFL 432
             + +R ++ ++ Q  ++++ +++++E+   +  Q E++ E +   C+     +EQ + +
Sbjct: 633 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM 692

Query: 433 PRIEETKWEVCQKAGEISLLKQQLK 457
            R EE  WE      E+ L +Q+ K
Sbjct: 693 RRQEEKMWE-----QEVRLRQQEEK 712



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 69/383 (18%), Positives = 154/383 (40%), Gaps = 49/383 (12%)

Query: 321 IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA- 379
           +Q +E    E +  V  L+R LE+++  + Q   ++ +A    L +  Q  S KLQ    
Sbjct: 291 LQLVESEKSEIQLNVKELKRKLERAKLLLPQ---QQLQAEADHLGKELQSVSAKLQAQVE 347

Query: 380 ------RRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQK------E 427
                 R  Q+ ++ +  Q  ++Q+ ++++QE+  ++  Q E++ ++    ++      E
Sbjct: 348 ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE 407

Query: 428 QADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQ----------- 476
           + + + R EE  WE  +K      +  + ++   ++ +K+ E   +R Q           
Sbjct: 408 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 467

Query: 477 ------------------LREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLK 518
                             +RE    +RE+EE++    +    ++   E  + +      +
Sbjct: 468 EQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWR 527

Query: 519 PALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVG 578
                 +  E           E K+R+Q            D E +   +      + E  
Sbjct: 528 QEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKI 587

Query: 579 RLQAELAAERRARERQGASFAEERRVWL-EEKEKVIEYQKQLQLSYVEMYQRNQQL---E 634
           R Q E   E+  + R+     +E+   + E++EK+ E ++++Q    +M ++ +++   E
Sbjct: 588 REQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQE 647

Query: 635 RRLRERGAAGGASTPTPQHGEEK 657
           +++RE+           Q  EEK
Sbjct: 648 KKIREQEEKIREQEEMMQEQEEK 670



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 22/94 (23%), Positives = 51/94 (54%), Gaps = 6/94 (6%)

Query: 321 IQELEERLWEKEQEVAALRRSLEQSEAAVAQ----VLEERQKAWERELAELRQGCSGKLQ 376
           +QE EE++  +E+++    + + + E  + +    + E+ +K WE+E     Q    K+Q
Sbjct: 629 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ--EEKMQ 686

Query: 377 QVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARL 410
           +   + +R ++ +  Q +RL+Q ++++QE    L
Sbjct: 687 EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 64/297 (21%), Positives = 130/297 (43%), Gaps = 25/297 (8%)

Query: 354 EERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQ 413
           E+ QKA  +    LR+    ++  + R     +  LQ+ +   Q   KQL+ EA  L+ +
Sbjct: 169 EDEQKASHQHQEALRRELEAQVHTI-RILTCQKTELQMALYYSQHAVKQLEGEARDLISR 227

Query: 414 RE-------ELEDKVAAC--QKEQAD-FLPRIEETKWEVCQKAGEISLLKQQLKDSQADV 463
                    ELE  ++A   QK++AD ++  + + +  +  +    ++  ++LK+  A +
Sbjct: 228 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 287

Query: 464 SQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTP 523
            +KL  +   +S+++     L+ K E+   L      +  +  LG+ EL +   K     
Sbjct: 288 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK-ELQSVSAK-LQAQ 345

Query: 524 VDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAE 583
           V+  E  + L   +  E KM RQ            + E +   +      + E  R Q E
Sbjct: 346 VEENELWNRLN--QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE 403

Query: 584 LAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRER 640
           +  E+  + R+     +E  +W  EKE+ +  Q+++     E  ++ ++LE ++ E+
Sbjct: 404 MMWEKEEKMRR-----QEEMMW--EKEEKMRRQEEMMW---EKEEKIRELEEKMHEQ 450



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 17/74 (22%), Positives = 40/74 (54%), Gaps = 12/74 (16%)

Query: 320 LIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVA 379
           ++QE EE++WE+E+++      +++ E    ++  + +K WE+E+         +L+Q  
Sbjct: 663 MMQEQEEKMWEQEEKMCEQEEKMQEQE---EKMRRQEEKMWEQEV---------RLRQQE 710

Query: 380 RRAQRAQQGLQLQV 393
            + Q  Q+ L+  +
Sbjct: 711 EKMQEHQEHLEAAI 724


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 73/349 (20%), Positives = 145/349 (41%), Gaps = 35/349 (10%)

Query: 312  CSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGC 371
            C   S      +L +R      E + L   + + E  VA++ +++ +  E EL ++R+  
Sbjct: 1110 CKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRV-EEELPKVREAA 1168

Query: 372  SGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELE---DKVAACQKEQ 428
              +L    R+ QR  + + LQ +R + + KQ + E   ++R++E  E   ++V     E 
Sbjct: 1169 ENEL----RKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEA 1224

Query: 429  ADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKE 488
                  +EE       +  E +  ++ L+D        L+++   +++L E     R+ E
Sbjct: 1225 EAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNE 1284

Query: 489  EQLLSL-----RD-SFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAK 542
            E+LL L     +D +F  + A  +L E +      +  +T +     ++AL  C      
Sbjct: 1285 EELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCP----- 1339

Query: 543  MRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQA----------ELAAERRARE 592
                  +  A S  +V G  +   +     L+++V  L A          EL  E  A +
Sbjct: 1340 ------ITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQ 1393

Query: 593  RQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERG 641
             +  S  E+ R+  ++ ++     + L+L      Q  +   ++LRE G
Sbjct: 1394 LEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELG 1442



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 73/332 (21%), Positives = 140/332 (42%), Gaps = 46/332 (13%)

Query: 321  IQELEERLWEKEQEVA-ALRRSLEQSEAAVAQV------LEERQKAWERELAELRQGCSG 373
            ++  + ++ E + E +  L   L Q +  V+++      ++E QK  E+  A ++     
Sbjct: 983  VETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY--- 1039

Query: 374  KLQQVARRAQ-RAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFL 432
            +LQ +  RA   +QQ   ++  R+Q     + +E   L  +   L   +    K   D L
Sbjct: 1040 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL 1099

Query: 433  PRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK----E 488
             R+EE + + C++  E       L+  +A V +  S++ G  S+L    A L+++    E
Sbjct: 1100 KRLEEEEIKRCKETSEHGAYSDLLQRQKATVLEN-SKLTGKISELERMVAELKKQKSRVE 1158

Query: 489  EQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAG 548
            E+L  +R++  ++               L+     V+    Q   A  ES+  + RR+  
Sbjct: 1159 EELPKVREAAENE---------------LRKQQRNVEDISLQKIRA--ESEAKQYRRE-- 1199

Query: 549  VAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEE 608
                  L ++  E EA      R L R V +L  E  A+R A E    +F  +       
Sbjct: 1200 ------LETIVREKEA----AERELER-VRQLTIEAEAKRAAVEENLLNFRNQLEENTFT 1248

Query: 609  KEKVIEYQKQLQLSYVEMYQRNQQLERRLRER 640
            +  + ++ K+  LS  ++ Q+  +L   LR +
Sbjct: 1249 RRTLEDHLKRKDLSLNDLEQQKNKLMEELRRK 1280



 Score = 37.4 bits (85), Expect = 0.045
 Identities = 53/309 (17%), Positives = 121/309 (39%), Gaps = 24/309 (7%)

Query: 330  EKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGL 389
            E   ++  L   LE+S    A++L+++ +   R+        + + + + +R Q   + +
Sbjct: 1550 ENNDKIQRLNEELEKSNEC-AEMLKQKVEELTRQ--------NNETKLMMQRIQAESENI 1600

Query: 390  QLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEI 449
             L+   +QQ  + L+ +A     Q     + +    K + DF  +I+  + ++ +    +
Sbjct: 1601 VLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLV 1660

Query: 450  SLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGE 509
            S  KQ+       +     E+  L ++L   +   R  E+++   +         L+  +
Sbjct: 1661 SEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQ 1720

Query: 510  GELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESG 569
             EL    ++  +T       Q+     +    + R++      + +++         E+ 
Sbjct: 1721 DELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVIT---------END 1771

Query: 570  TRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEK-EKVIEYQKQLQLSYVEMYQ 628
               +R +   LQ E      +R ++ A   E     LE + ++  E  +Q Q      YQ
Sbjct: 1772 ISGIRLDFVSLQQE-----NSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQ 1826

Query: 629  RNQQLERRL 637
            + Q+LE  L
Sbjct: 1827 KCQKLEDEL 1835


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 78/344 (22%), Positives = 141/344 (40%), Gaps = 35/344 (10%)

Query: 323  ELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQ------KAWERELAEL--------- 367
            +L+E+L   ++ +   + SLE+ +   A  LEE+Q      KA  R L E          
Sbjct: 699  QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELE 758

Query: 368  -----RQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVA 422
                 R+G   +LQQ+    Q   + L+ ++      +   + E  +L+++     ++  
Sbjct: 759  EERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYE 818

Query: 423  ACQKEQADFLPRIEE---TKWEVCQKA-GEISLLKQQL----KDSQADVSQKLSEIVGLR 474
              Q+E+A +    +E   T  E C+KA  E+   K+++      S+  +S++ +E+  L 
Sbjct: 819  DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878

Query: 475  SQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALA 534
            + L      ++EKE +   L D  S+ Q  +     E+  A L+   T V  A  Q   A
Sbjct: 879  ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV--ARLE---TLVRKAGEQQETA 933

Query: 535  TCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQ 594
            + E    K   +AG      L    G      ++  +A+ RE  ++  EL   R A    
Sbjct: 934  SREL--VKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMES 991

Query: 595  GASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLR 638
                 EER     E  ++ + + + Q           +LE RL+
Sbjct: 992  QGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 72/322 (22%), Positives = 142/322 (44%), Gaps = 39/322 (12%)

Query: 323 ELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRA 382
           +L + L ++EQ    LR  +EQ  +++ Q  ++ ++  E++ A  +       QQ+A  A
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQD----HAQQLATAA 589

Query: 383 QRAQQGLQLQVLRLQQDKKQLQEEAARL----------MRQREELEDKVAACQKEQADFL 432
           +  +  L+ +   L+Q +   +E+AA+L             R+  +  V   Q+E+A+  
Sbjct: 590 EEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 649

Query: 433 PRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK---EE 489
            ++EE   + C     +   +Q+  ++QA V++   ++   + +  E     +EK   +E
Sbjct: 650 RKVEEL--QAC-----VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQE 702

Query: 490 QLLSLRDSFSSKQASLELGEGELPAACLKPALTPVD--PAEPQDALATCESDEAKMRRQ- 546
           QL +L++S    + SLE  E    A  L+     +    AE +  +   + +  ++  + 
Sbjct: 703 QLQALKESLKVTKGSLE-EEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEER 761

Query: 547 AGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWL 606
           AG     + +   GEA    ++ T  LRRE+    AE  A +   E +     +E   W 
Sbjct: 762 AGRKGLEARLQQLGEAH---QAETEVLRREL----AEAMAAQHTAESECEQLVKEVAAWR 814

Query: 607 EEKEKVIEYQKQLQLSYVEMYQ 628
           E  E      +Q +  Y  M+Q
Sbjct: 815 ERYED----SQQEEAQYGAMFQ 832



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 80/321 (24%), Positives = 139/321 (43%), Gaps = 55/321 (17%)

Query: 332 EQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQL 391
           +QE A L  +  Q +A V  +  ER +   + LAE      G  ++  ++       LQ 
Sbjct: 419 KQEAATLAANNTQLQARVEMLETERGQQEAKLLAE-----RGHFEEEKQQLSSLITDLQS 473

Query: 392 QVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISL 451
            +  L Q K++L E+A++    R  L  +VA+   E       I+       Q+  E++ 
Sbjct: 474 SISNLSQAKEEL-EQASQAHGAR--LTAQVASLTSELTTLNATIQ-------QQDQELAG 523

Query: 452 LKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGE 511
           LKQQ K+ QA ++Q L +    + Q  +G   LR + EQL S          SL+  E +
Sbjct: 524 LKQQAKEKQAQLAQTLQQ----QEQASQG---LRHQVEQLSS----------SLKQKEQQ 566

Query: 512 LPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTR 571
           L     K   T  D A  Q      E  EA +R +   AA   L +++ E         +
Sbjct: 567 LKEVAEKQEATRQDHA--QQLATAAEEREASLRERD--AALKQLEALEKE---------K 613

Query: 572 ALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVI----------EYQKQLQL 621
           A + E+ + Q ++A E R   +   + A+  +  L  K + +          +++ Q Q+
Sbjct: 614 AAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQV 673

Query: 622 SYVEMYQRNQQLERRLRERGA 642
           + +E+  R++Q +   +ER A
Sbjct: 674 AELELQLRSEQQKATEKERVA 694



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 90/377 (23%), Positives = 151/377 (40%), Gaps = 61/377 (16%)

Query: 318  SALIQELEERLWEKEQEVAA---LRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGK 374
            SAL +E++    E E++  A   LR+ L  S+A  A+ L +  KAW+ +  +  Q  S  
Sbjct: 1288 SALREEVQSLREEAEKQRVASENLRQELT-SQAERAEELGQELKAWQEKFFQKEQALS-- 1344

Query: 375  LQQVARRAQRAQQGLQLQVLRLQQDKKQLQ-EEAARLMRQREELEDKVAACQKEQADFLP 433
                 +    + Q L  ++L  +   +QLQ E+AA   R REELE    A    +A+ L 
Sbjct: 1345 ---TLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL- 1400

Query: 434  RIEETKWEVC---QKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREK--- 487
            R +    E+    QK  E     QQL+  +A  +++LS +      L E    L E+   
Sbjct: 1401 RAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL 1460

Query: 488  -----EEQLLSLRDSFSSKQASLELG----------EGELPAACLKPALTPVDPA----- 527
                 E +L   R+ +  + A++             E +  A  L+      + A     
Sbjct: 1461 GRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL 1520

Query: 528  --------EPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEA-------------GG 566
                    E Q   A  E  E   R Q       S    D +  +             GG
Sbjct: 1521 EERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGG 1580

Query: 567  ESGTRA--LRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYV 624
            ES   A  L+ ++  LQA+L+ + +A E       + +  +  +K++  E Q+QL+ S  
Sbjct: 1581 ESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR-SLE 1639

Query: 625  EMYQRNQQLERRLRERG 641
            ++ + N++L       G
Sbjct: 1640 QLQKENKELRAEAERLG 1656



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 76/294 (25%), Positives = 119/294 (40%), Gaps = 23/294 (7%)

Query: 351 QVLEERQKA--WERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAA 408
           Q+ +ER      E ELAE R+  + K  Q+A   QR  +   L +L  +Q    L+    
Sbjct: 222 QLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR---LALLNEKQAASPLEP--- 275

Query: 409 RLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLS 468
              ++ EEL DK  +      + L + ++ K E  Q   +I+    QL +   D+S KL 
Sbjct: 276 ---KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKIN----QLSEENGDLSFKLR 328

Query: 469 EIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAE 528
           E      QL++   +L E  E+       +  KQA LE    EL AA             
Sbjct: 329 EFASHLQQLQD---ALNELTEEHSKATQEWLEKQAQLEK---ELSAALQDKKCLEEKNEI 382

Query: 529 PQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAER 588
            Q  L+  E   ++++          L  V        E+ T A      +LQA +    
Sbjct: 383 LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNT--QLQARVEMLE 440

Query: 589 RARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGA 642
             R +Q A    ER  + EEK+++      LQ S   + Q  ++LE+  +  GA
Sbjct: 441 TERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGA 494



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 89/333 (26%), Positives = 140/333 (42%), Gaps = 50/333 (15%)

Query: 319  ALIQELEERLWEKEQEVAALRRSLEQSEAAVAQ---VLEERQKAWERELAELRQGCSGKL 375
            A + +LE++  +++++  +L RSLE   A+ A+    LE  Q   E +  EL     G  
Sbjct: 1127 AEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQEL-----GHS 1181

Query: 376  QQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDK--VAACQKEQADFLP 433
            Q     AQR     + +V   Q   K   E  A++ R R+E E K  + +  +E+   L 
Sbjct: 1182 QSALASAQRELAAFRTKV---QDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN 1238

Query: 434  RIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGL---------------RSQLR 478
            R      +V +K GE   LK +L  ++++ SQKL E + L                S LR
Sbjct: 1239 R------QVLEKEGESKELK-RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALR 1291

Query: 479  EGRASLREKEEQLL----SLRDSFSSK-QASLELGEGELPAACLK-----PALTPVDPAE 528
            E   SLRE+ E+      +LR   +S+ + + ELG+ EL A   K      AL+ +    
Sbjct: 1292 EEVQSLREEAEKQRVASENLRQELTSQAERAEELGQ-ELKAWQEKFFQKEQALSTLQLEH 1350

Query: 529  PQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAER 588
                    E   AK   Q   A  A+      E     +     LR E+ R Q EL    
Sbjct: 1351 TSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELI 1410

Query: 589  RARERQGASFAEERRVWLEEKEKVIEYQKQLQL 621
              R++     AE+ R   + + +   Y +QL +
Sbjct: 1411 PLRQK----VAEQERTAQQLRAEKASYAEQLSM 1439



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 87/390 (22%), Positives = 145/390 (37%), Gaps = 66/390 (16%)

Query: 325  EERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWER---ELAELRQGCSGKLQQVARR 381
            +E+L   ++E    R+ L++++  VA +    +    R   ELAEL    +  LQQV  +
Sbjct: 832  QEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEK 891

Query: 382  AQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRI------ 435
              RAQ        +L  D   LQE+ A   ++   LE  V    ++Q      +      
Sbjct: 892  EVRAQ--------KLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPAR 943

Query: 436  ---EETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLRE----KE 488
                + +W   Q+  +    +  L+  + +  Q  +E+  LR+ L E +   +E    +E
Sbjct: 944  AGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE 1003

Query: 489  EQLLSLRDSFSSKQASLEL---GEGELPAACLKPALTP--VDPAEPQDALATC----ESD 539
             ++  L       QA L L      EL    L+ AL    V+ A  Q+ALA      E  
Sbjct: 1004 REVARLTQERGRAQADLALEKAARAELEMR-LQNALNEQRVEFATLQEALAHALTEKEGK 1062

Query: 540  EAKMRRQAGVAAA----------------ASLVSVDGE--------AEAGGES-----GT 570
            + ++ +  G+ AA                  L   + E        +EA G +       
Sbjct: 1063 DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL 1122

Query: 571  RALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRN 630
             ALR EV +L+ +   ++   +    S   ER    E    +   Q QL+    E+    
Sbjct: 1123 EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQ 1182

Query: 631  QQLERRLRERGAAGGASTPTPQHGEEKKAW 660
              L    RE  A     T    H + +  W
Sbjct: 1183 SALASAQRELAA---FRTKVQDHSKAEDEW 1209



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 76/349 (21%), Positives = 143/349 (40%), Gaps = 44/349 (12%)

Query: 322  QELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWER----------ELAELRQGC 371
            Q+ EER  ++E+EVA L +   +++A +A     R +   R          E A L++  
Sbjct: 994  QQQEER-GQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEAL 1052

Query: 372  S-------GKLQQVAR-RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAA 423
            +       GK Q++A+ R   A Q  +L+ LR  Q  KQL+E+ A+  ++        A+
Sbjct: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELR--QTVKQLKEQLAKKEKEH-------AS 1103

Query: 424  CQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRAS 483
                Q++   R E T  ++     E+S L+QQ +  Q         +   R+   E  ++
Sbjct: 1104 GSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSA 1163

Query: 484  LREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKM 543
            L   + QL          Q++L   + EL  A  +  +     AE +         +   
Sbjct: 1164 LETLQGQLEEKAQELGHSQSALASAQREL--AAFRTKVQDHSKAEDEWKAQVARGRQEAE 1221

Query: 544  RRQAGVAAAASLVSV--------DGEAE------AGGESGTRALRREVGRLQAELAAERR 589
            R+ + +++    VS+        +GE++            ++ L   +  LQAE A+   
Sbjct: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA 1281

Query: 590  ARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLR 638
                + ++  EE +   EE EK     + L+       +R ++L + L+
Sbjct: 1282 RAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELK 1330



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 52/216 (24%), Positives = 104/216 (48%), Gaps = 23/216 (10%)

Query: 318  SALIQELEERLWEKEQEVAALRRSLE----QSEAAVAQVLEERQKAWER---------EL 364
            +A+  + E RL E ++E  +  R LE    + E A  +VLEERQ+  E          +L
Sbjct: 1481 AAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL 1540

Query: 365  AELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQ---LQEEAARLMRQREELEDKV 421
               ++  + ++++++++   + Q  ++Q  +L+  + Q    Q+EA RL  Q  EL+ ++
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600

Query: 422  AACQKEQA--DFLPRIEETKWEVCQKAGEISLLKQQLK---DSQADVSQKLSEIVGLRSQ 476
            +  QKEQA   +  ++E+ K     K  +   L++QL+     Q +  +  +E   L  +
Sbjct: 1601 S--QKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHE 1658

Query: 477  LREGRASLREKEEQLLSLRDSFSSKQASLELGEGEL 512
            L++     +E E+    L     S +A +   + +L
Sbjct: 1659 LQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQL 1694


>gi|4505257 moesin [Homo sapiens]
          Length = 577

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 45/170 (26%), Positives = 95/170 (55%), Gaps = 12/170 (7%)

Query: 321 IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
           +Q+++ +  E++ +   + R++ ++E    ++ E+ ++  ERE  EL +    +L+Q+  
Sbjct: 302 VQQMKAQAREEKHQ-KQMERAMLENEKKKREMAEKEKEKIEREKEELME----RLKQIEE 356

Query: 381 RAQRAQQGLQLQV---LRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEE 437
           + ++AQQ L+ Q    L L+Q++K+ Q EA +L ++R+E E+   A  +   D     E+
Sbjct: 357 QTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQ 416

Query: 438 TKWEVCQKAGEISLLK--QQLKDSQADVSQKLSEIVGLRSQLREGRASLR 485
              E+ +    IS L+  +Q K+S+A   Q+ +++V  +  L + RA L+
Sbjct: 417 LALEMAELTARISQLEMARQKKESEAVEWQQKAQMV--QEDLEKTRAELK 464



 Score = 37.4 bits (85), Expect = 0.045
 Identities = 32/105 (30%), Positives = 49/105 (46%), Gaps = 2/105 (1%)

Query: 567 ESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEM 626
           E   RAL  E  R +A+  AE+ A+ERQ A  A+E  +     +K  + Q+QL L   E+
Sbjct: 367 EQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQK--KTQEQLALEMAEL 424

Query: 627 YQRNQQLERRLRERGAAGGASTPTPQHGEEKKAWTPSRLERIEST 671
             R  QLE   +++ +         Q  +E    T + L+   ST
Sbjct: 425 TARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMST 469



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 49/245 (20%), Positives = 102/245 (41%), Gaps = 25/245 (10%)

Query: 355 ERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQR 414
           ++ KA  RE    +Q     L+   ++ + A++  +    +++++K++L E     ++Q 
Sbjct: 303 QQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKE----KIEREKEELMER----LKQI 354

Query: 415 EELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDS-----QADVSQKLS- 468
           EE   K     +EQ      +E+ +     +A +++  +Q+ +++     QA   QK + 
Sbjct: 355 EEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQ 414

Query: 469 -----EIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTP 523
                E+  L +++ +   + ++KE + +  +      Q  LE    EL  A   P +  
Sbjct: 415 EQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHV-- 472

Query: 524 VDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAE 583
            +PAE +      E DE      A + A A       E           +++ +  L +E
Sbjct: 473 AEPAENEQD----EQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSE 528

Query: 584 LAAER 588
           LA  R
Sbjct: 529 LANAR 533


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 79/323 (24%), Positives = 143/323 (44%), Gaps = 43/323 (13%)

Query: 323 ELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERE--LAELRQGCSGKLQQVAR 380
           E  ER+ E+E+  A  R+ +++ E   A   EERQ+  E E   AE RQ    + ++ A 
Sbjct: 312 EERERMREEEKRAAEERQRIKEEEKRAA---EERQRIKEEEKRAAEERQRIKEEEKRAAE 368

Query: 381 RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQ--KEQADFLPRIEET 438
             QRA         R ++++K   EE  R     ++LE+K  A Q  K + + + +  E 
Sbjct: 369 ERQRA---------RAEEEEKAKVEEQKR----NKQLEEKKHAMQETKIKGEKVEQKIEG 415

Query: 439 KWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSF 498
           KW   +KA E  L    LK       +K +++   R +L+E + + +++E +   ++   
Sbjct: 416 KWVNEKKAQEDKLQTAVLKKQG---EEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDK 472

Query: 499 SSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSV 558
             K+      +        K   T V     +      +  E    R  G    AS+ + 
Sbjct: 473 EPKEEVKSFMDR-------KKGFTEVKSQNGEFMTHKLKHTENTFSRPGG---RASVDTK 522

Query: 559 DGEAEAGGESGTRA--LRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQ 616
           + E     E+G R   LRR  G  ++E   + + ++++ A   EE +   EE+ KV+E +
Sbjct: 523 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 582

Query: 617 KQLQLSYVEMYQRNQQLERRLRE 639
           +Q         ++ ++ +R+LRE
Sbjct: 583 EQ--------RRKQEEADRKLRE 597



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 81/376 (21%), Positives = 151/376 (40%), Gaps = 43/376 (11%)

Query: 325 EERLWEKEQEVAALRRSLEQSEA-AVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQ 383
           +ERL +K++E  +L +  +Q E  A   V +E  K             +  L+++ARR +
Sbjct: 47  QERLRQKQEE-ESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE 105

Query: 384 RAQQGLQ-------------------LQVLRLQQDKKQLQ----EEAARLMRQREELEDK 420
           R Q+ LQ                   L   R+Q D  + +    EE +   ++R E+E+ 
Sbjct: 106 RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET 165

Query: 421 VAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREG 480
               +  Q +     EE K E  +K  E     ++ K  +  + +   E+      + E 
Sbjct: 166 ETVTKSYQKNDWRDAEENKKEDKEKEEE-----EEEKPKRGSIGENQVEV------MVEE 214

Query: 481 RASLREKEEQLLSLRDSFSSKQASLELGEGELPAACL----KPALTPVDPAEPQDA-LAT 535
           + +  ++E  ++SL++   S +   +  E E  +  +    K      + AE + A L  
Sbjct: 215 KTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEA 274

Query: 536 CESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQG 595
            E +  K  +   +A   + +  + +A A       A  RE  R + + AAE R R ++ 
Sbjct: 275 EERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEE 334

Query: 596 ASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGE 655
              A E R  ++E+EK    ++Q      +     +Q  R   E  A         Q  E
Sbjct: 335 EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEE 394

Query: 656 EKKAWTPSRL--ERIE 669
           +K A   +++  E++E
Sbjct: 395 KKHAMQETKIKGEKVE 410



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 23/92 (25%), Positives = 48/92 (52%)

Query: 330 EKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGL 389
           E  + +  LRR   ++E+   + L+++Q+    EL EL++    + + +    QR +Q  
Sbjct: 531 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 590

Query: 390 QLQVLRLQQDKKQLQEEAARLMRQREELEDKV 421
             + LR +++K++L+EE  R   +  E   K+
Sbjct: 591 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKM 622


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.127    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,116,454
Number of Sequences: 37866
Number of extensions: 1714790
Number of successful extensions: 24309
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 461
Number of HSP's successfully gapped in prelim test: 1318
Number of HSP's that attempted gapping in prelim test: 11534
Number of HSP's gapped (non-prelim): 8127
length of query: 673
length of database: 18,247,518
effective HSP length: 109
effective length of query: 564
effective length of database: 14,120,124
effective search space: 7963749936
effective search space used: 7963749936
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.