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Search of human proteins with 7662170
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
(661 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 1331 0.0
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 638 0.0
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 266 3e-71
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 262 9e-70
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 261 1e-69
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 261 2e-69
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 261 2e-69
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 256 4e-68
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 256 6e-68
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 256 6e-68
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 254 2e-67
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 253 3e-67
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 252 7e-67
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 251 1e-66
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 247 3e-65
gi|116256471 SNF1-like kinase [Homo sapiens] 247 3e-65
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 241 2e-63
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 238 1e-62
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 237 3e-62
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 233 6e-61
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 225 1e-58
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 213 5e-55
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 192 6e-49
gi|156105707 SNF related kinase [Homo sapiens] 190 3e-48
gi|156105705 SNF related kinase [Homo sapiens] 190 3e-48
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 183 5e-46
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 183 5e-46
gi|121114283 polo-like kinase 4 [Homo sapiens] 179 7e-45
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 179 9e-45
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 177 2e-44
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 1331 bits (3445), Expect = 0.0
Identities = 661/661 (100%), Positives = 661/661 (100%)
Query: 1 MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQET 60
MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQET
Sbjct: 1 MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQET 60
Query: 61 LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE 120
LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE
Sbjct: 61 LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE 120
Query: 121 VFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLK 180
VFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLK
Sbjct: 121 VFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLK 180
Query: 181 LENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALG 240
LENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALG
Sbjct: 181 LENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALG 240
Query: 241 VLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDI 300
VLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDI
Sbjct: 241 VLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDI 300
Query: 301 ANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEV 360
ANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEV
Sbjct: 301 ANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEV 360
Query: 361 MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGV 420
MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGV
Sbjct: 361 MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGV 420
Query: 421 VGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYS 480
VGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYS
Sbjct: 421 VGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYS 480
Query: 481 SPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPAL 540
SPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPAL
Sbjct: 481 SPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPAL 540
Query: 541 VSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRS 600
VSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRS
Sbjct: 541 VSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRS 600
Query: 601 CVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKL 660
CVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKL
Sbjct: 601 CVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKL 660
Query: 661 N 661
N
Sbjct: 661 N 661
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 638 bits (1646), Expect = 0.0
Identities = 369/640 (57%), Positives = 436/640 (68%), Gaps = 65/640 (10%)
Query: 38 KPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDM 97
K VKRHHHKHNL+HRYE ETLGKGTYGKVK+A E SGR+VAIKSIRKDKIKDEQD+
Sbjct: 36 KKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDL 94
Query: 98 VHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRH 157
+HIRREIEIMSSLNHPHII+I+EVFEN KIVI+MEYAS+G+LYDYISER++LSERE RH
Sbjct: 95 MHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARH 154
Query: 158 FFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPL 217
FFRQIVSAVHYCH+N VVHRDLKLENILLD N NIKIADFGLSNLY + KFLQTFCGSPL
Sbjct: 155 FFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPL 214
Query: 218 YASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS 277
YASPEIVNG+PY GPEVDSW+LGVLLY LV+GTMPFDG DHK L++QIS+G YREP +PS
Sbjct: 215 YASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPS 274
Query: 278 DARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSESP----LLARIID 333
DA GLIRW+LMVNP RRAT+ED+A+HWWVNWGY + V + +A H+ P A + D
Sbjct: 275 DACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMAD 334
Query: 334 WHHRSTGLQADTEAKMKGLAKP-----TTSEVMLERQRSLKKSKKENDFAQS----GQDA 384
W RS+ + AK+ K ++ LERQ SLKKS+KEND AQS D
Sbjct: 335 WLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADD 394
Query: 385 VPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPS 444
P K + K PKGILKK+ ++ EGV ++D
Sbjct: 395 TAHRPGKSNLKLPKGILKKKVSAS--------AEGV-----------QEDPPEL------ 429
Query: 445 SPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSP 504
SP PG+ +P +PKKGILKK +QRESGYYSSPE SES ELLD+ DV S P
Sbjct: 430 SPIPASPGQAAP----LLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKE 485
Query: 505 SPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESLSEPGVPAEGLSRS 564
P A L RKGILK + K+S ++ L +P T SL E P L+R+
Sbjct: 486 QKPPQA----SGLLLHRKGILKLNGKFSQTALE--LAAP--TTFGSLDEL-APPRPLARA 536
Query: 565 YSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQIQDFEGLQNRPRP-- 622
SRPS +S+DS+LSS+SFD LDL E P +R CVS +N GL+ P
Sbjct: 537 -SRPSGAVSEDSILSSESFDQLDLPERLP-EPPLRGCVSVDN------LTGLEEPPSEGP 588
Query: 623 -QYLKRYR-NRLADSSFSLLTDMDDVTQVYKQALEICSKL 660
L+R+R + L DS FS LTD +VT Y+QAL +CSKL
Sbjct: 589 GSCLRRWRQDPLGDSCFS-LTDCQEVTATYRQALRVCSKL 627
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 266 bits (681), Expect = 3e-71
Identities = 176/516 (34%), Positives = 261/516 (50%), Gaps = 20/516 (3%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y L T+GKG + KVK A +GR VAIK I K ++ + + + RE+ IM LNHP+
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPSSLQKLFREVRIMKGLNHPN 117
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
I+ ++EV E + + ++MEYAS GE++DY+ R+ E+E R FRQIVSAVHYCH+ +
Sbjct: 118 IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNI 177
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
VHRDLK EN+LLD NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEV
Sbjct: 178 VHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEV 237
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293
D W+LGV+LYTLV G++PFDG + K L ++ G+YR P S D ++R L++NP +
Sbjct: 238 DIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAK 297
Query: 294 RATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLA 353
R T+E I W+N GY+ + + RI G+ E + L
Sbjct: 298 RCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRI----EVMVGMGYTREEIKESLT 353
Query: 354 KPTTSEVMLERQRSLKKSKKEND-----FAQSGQDAVPESPSKLSSKRPKGILKKRSNSE 408
+EV +K+++ D A + A ++ + SS + K + +S
Sbjct: 354 SQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSS 413
Query: 409 HRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGIL 468
H GP+ P+ ++ TG E +PG+ + +A +G+
Sbjct: 414 STYHRQRRHSDFCGPS-PAPLHPKRSPTSTGE--AELKEERLPGRKASCSTAGSGSRGLP 470
Query: 469 KKTQQRESGYYSSPERSESSE-LLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKH 527
+ S + +P ++E E DS + PS V + R +L +
Sbjct: 471 PSSPMVSSAH--NPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPN 528
Query: 528 SSKYSAGTMDPALVSPEMPTLESLSEPGVPAEGLSR 563
+ S+GT V P P+ SL+ P L+R
Sbjct: 529 GKENSSGT---PRVPPASPSSHSLAPPSGERSRLAR 561
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 262 bits (669), Expect = 9e-70
Identities = 191/634 (30%), Positives = 294/634 (46%), Gaps = 68/634 (10%)
Query: 7 PVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTY 66
P +R + G R+ V T+ R + + + Y L +T+GKG +
Sbjct: 8 PTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNF 67
Query: 67 GKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKD 126
KVK A +GR VAIK I K ++ + + + RE+ IM LNHP+I+ ++EV E +
Sbjct: 68 AKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFEVIETEK 126
Query: 127 KIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILL 186
+ +IMEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ +VHRDLK EN+LL
Sbjct: 127 TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLL 186
Query: 187 DDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTL 246
D + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEVD W+LGV+LYTL
Sbjct: 187 DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 246
Query: 247 VYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRATIEDIANHWW 305
V G++PFDG + K L ++ G+YR P S D L++ L++NP +R T+E I W
Sbjct: 247 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRW 306
Query: 306 VNWGYKSSVCDCDALHDSESPLLARIIDWHHRS-----TGLQADTEAKMKGLAKPTTSEV 360
+N G++ D P + +D + G+ E + L+K E+
Sbjct: 307 INAGHE---------EDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 357
Query: 361 MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGV 420
+KS + + D + K + + + + H+ I V
Sbjct: 358 TATYLLLGRKSSE----VRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSV 413
Query: 421 VG-PALPSTFKMEQDLCRTGV--------------LLPSSP---------EAEVPGKLSP 456
V P T + DL G+ + P+SP +A++P +
Sbjct: 414 VAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPER--- 470
Query: 457 KQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHS 516
K+S+T+P R + Y S + + N S+IP P ++HS
Sbjct: 471 KKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTP---VASTHS 527
Query: 517 LSCRR--------KGILKHSSKYSAGTMDPALVSPEMPTLESLSEPGVP-----AEGLSR 563
+S +G S+ + P SLS P + G +
Sbjct: 528 ISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTN 587
Query: 564 SYSRPSSVISDDSVLSSDSFDLLDLQENRPARQR 597
+S+ +S ++ +S++ D EN+ A+ R
Sbjct: 588 LFSKLTSKLTRSRNVSAEQKD-----ENKEAKPR 616
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 261 bits (668), Expect = 1e-69
Identities = 195/646 (30%), Positives = 301/646 (46%), Gaps = 76/646 (11%)
Query: 7 PVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTY 66
P +R + G R+ V T+ R + + + Y L +T+GKG +
Sbjct: 8 PTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNF 67
Query: 67 GKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKD 126
KVK A +GR VAIK I K ++ + + + RE+ IM LNHP+I+ ++EV E +
Sbjct: 68 AKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFEVIETEK 126
Query: 127 KIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILL 186
+ +IMEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ +VHRDLK EN+LL
Sbjct: 127 TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLL 186
Query: 187 DDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTL 246
D + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEVD W+LGV+LYTL
Sbjct: 187 DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 246
Query: 247 VYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRATIEDIANHWW 305
V G++PFDG + K L ++ G+YR P S D L++ L++NP +R T+E I W
Sbjct: 247 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRW 306
Query: 306 VNWGYKSSVCDCDALHDSESPLLARIIDWHHRS-----TGLQADTEAKMKGLAKPTTSEV 360
+N G++ D P + +D + G+ E + L+K E+
Sbjct: 307 INAGHE---------EDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 357
Query: 361 ----MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGF 416
+L ++S + ++ + + A S L++ + K S S
Sbjct: 358 TATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRR 417
Query: 417 IEGVVGPALPS---------TFKMEQDLCRTGV--------------LLPSSP------- 446
GPA+PS T + DL G+ + P+SP
Sbjct: 418 YSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASN 477
Query: 447 --EAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSP 504
+A++P + K+S+T+P R + Y S + + N S+IP
Sbjct: 478 PNKADIPER---KKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQ 534
Query: 505 SPPDPARVTSHSLSCRR--------KGILKHSSKYSAGTMDPALVSPEMPTLESLSEPGV 556
P ++HS+S +G S+ + P SLS
Sbjct: 535 RTP---VASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEAT 591
Query: 557 P-----AEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQR 597
P + G + +S+ +S ++ +S++ D EN+ A+ R
Sbjct: 592 PLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKD-----ENKEAKPR 632
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 261 bits (666), Expect = 2e-69
Identities = 179/554 (32%), Positives = 270/554 (48%), Gaps = 58/554 (10%)
Query: 7 PVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTY 66
P +R + G R+ V T+ R + + + Y L +T+GKG +
Sbjct: 8 PTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNF 67
Query: 67 GKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKD 126
KVK A +GR VAIK I K ++ + + + RE+ IM LNHP+I+ ++EV E +
Sbjct: 68 AKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFEVIETEK 126
Query: 127 KIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILL 186
+ +IMEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ +VHRDLK EN+LL
Sbjct: 127 TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLL 186
Query: 187 DDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTL 246
D + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEVD W+LGV+LYTL
Sbjct: 187 DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 246
Query: 247 VYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRATIEDIANHWW 305
V G++PFDG + K L ++ G+YR P S D L++ L++NP +R T+E I W
Sbjct: 247 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRW 306
Query: 306 VNWGYKSSVCDCDALHDSESPLLARIIDWHHRS-----TGLQADTEAKMKGLAKPTTSEV 360
+N G++ D P + +D + G+ E + L+K E+
Sbjct: 307 INAGHE---------EDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 357
Query: 361 ----MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGF 416
+L ++S + ++ + + A S L++ + K S S
Sbjct: 358 TATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRR 417
Query: 417 IEGVVGPALPS---------TFKMEQDLCRTGV--------------LLPSSP------- 446
GPA+PS T + DL G+ + P+SP
Sbjct: 418 YSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASN 477
Query: 447 --EAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSP 504
+A++P + K+S+T+P R + Y S + + N S+IP
Sbjct: 478 PNKADIPER---KKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQ 534
Query: 505 SPPDPARVTSHSLS 518
P ++HS+S
Sbjct: 535 RTP---VASTHSIS 545
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 261 bits (666), Expect = 2e-69
Identities = 179/554 (32%), Positives = 270/554 (48%), Gaps = 58/554 (10%)
Query: 7 PVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTY 66
P +R + G R+ V T+ R + + + Y L +T+GKG +
Sbjct: 8 PTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNF 67
Query: 67 GKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKD 126
KVK A +GR VAIK I K ++ + + + RE+ IM LNHP+I+ ++EV E +
Sbjct: 68 AKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFEVIETEK 126
Query: 127 KIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILL 186
+ +IMEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ +VHRDLK EN+LL
Sbjct: 127 TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLL 186
Query: 187 DDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTL 246
D + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEVD W+LGV+LYTL
Sbjct: 187 DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 246
Query: 247 VYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRATIEDIANHWW 305
V G++PFDG + K L ++ G+YR P S D L++ L++NP +R T+E I W
Sbjct: 247 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRW 306
Query: 306 VNWGYKSSVCDCDALHDSESPLLARIIDWHHRS-----TGLQADTEAKMKGLAKPTTSEV 360
+N G++ D P + +D + G+ E + L+K E+
Sbjct: 307 INAGHE---------EDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 357
Query: 361 ----MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGF 416
+L ++S + ++ + + A S L++ + K S S
Sbjct: 358 TATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRR 417
Query: 417 IEGVVGPALPS---------TFKMEQDLCRTGV--------------LLPSSP------- 446
GPA+PS T + DL G+ + P+SP
Sbjct: 418 YSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASN 477
Query: 447 --EAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSP 504
+A++P + K+S+T+P R + Y S + + N S+IP
Sbjct: 478 PNKADIPER---KKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQ 534
Query: 505 SPPDPARVTSHSLS 518
P ++HS+S
Sbjct: 535 RTP---VASTHSIS 545
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 256 bits (655), Expect = 4e-68
Identities = 192/605 (31%), Positives = 286/605 (47%), Gaps = 90/605 (14%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y L +T+GKG + KVK A +G+ VA+K I K ++ + + + RE+ IM LNHP+
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 78
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
I+ ++EV E + + ++MEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ +
Sbjct: 79 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 138
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
VHRDLK EN+LLD + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEV
Sbjct: 139 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 198
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293
D W+LGV+LYTLV G++PFDG + K L ++ G+YR P S D L++ L++NP +
Sbjct: 199 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 258
Query: 294 RATIEDIANHWWVNWGYKSSVCD--CDALHDSESP------------------------- 326
R T+E I W+N G++ + L D + P
Sbjct: 259 RGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRY 318
Query: 327 --LLARIIDWHHRSTGLQADT-------EAKMKGLAKPTTSEVMLERQRSLKKSKKENDF 377
++A + ++S+ L+ DT A + + P+ S + QRS+ + K+ F
Sbjct: 319 NEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKV---QRSVSANPKQRRF 375
Query: 378 AQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCR 437
+ A+P S S + KR + S G ST K
Sbjct: 376 SDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRES----------GRKASSTAK------- 418
Query: 438 TGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVM 497
+P+SP +PG K + T +L +S RS +S LL+ +
Sbjct: 419 ----VPASP---LPGLERKKTTPTPSTNSVLS----------TSTNRSRNSPLLERASLG 461
Query: 498 GSSIPS-----PSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESLS 552
+SI + P A S S + +H SA ++ P S PT +
Sbjct: 462 QASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSA-SVHPNKASGLPPTESNCE 520
Query: 553 EPGVPAEGLSRSYSRPSSV-ISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQIQ 611
P R + P V ++ S + S + N P RS A Q++
Sbjct: 521 VP--------RPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVR 572
Query: 612 DFEGL 616
D + L
Sbjct: 573 DQQNL 577
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 256 bits (653), Expect = 6e-68
Identities = 171/507 (33%), Positives = 256/507 (50%), Gaps = 81/507 (15%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y L +T+GKG + KVK A +G+ VA+K I K ++ + + + RE+ IM LNHP+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
I+ ++EV E + + ++MEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ +
Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
VHRDLK EN+LLD + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEV
Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293
D W+LGV+LYTLV G++PFDG + K L ++ G+YR P S D L++ L++NP +
Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291
Query: 294 RATIEDIANHWWVNWGYKSSVCD--CDALHDSESP------------------------- 326
R T+E I W+N G++ + L D + P
Sbjct: 292 RGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRY 351
Query: 327 --LLARIIDWHHRSTGLQADT-------EAKMKGLAKPTTSEVMLERQRSLKKSKKENDF 377
++A + ++S+ L+ DT A + + P+ S + QRS+ + K+ F
Sbjct: 352 NEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKV---QRSVSANPKQRRF 408
Query: 378 AQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCR 437
+ A+P S S + KR + S G ST K
Sbjct: 409 SDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRES----------GRKASSTAK------- 451
Query: 438 TGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVM 497
+P+SP +PG K + T +L +S RS +S LL+ +
Sbjct: 452 ----VPASP---LPGLERKKTTPTPSTNSVLS----------TSTNRSRNSPLLERASLG 494
Query: 498 GSSI------PSPSPPDPARVTSHSLS 518
+SI +P A ++H++S
Sbjct: 495 QASIQNGKDSTAPQRVPVASPSAHNIS 521
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 256 bits (653), Expect = 6e-68
Identities = 171/507 (33%), Positives = 256/507 (50%), Gaps = 81/507 (15%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y L +T+GKG + KVK A +G+ VA+K I K ++ + + + RE+ IM LNHP+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
I+ ++EV E + + ++MEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ +
Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
VHRDLK EN+LLD + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEV
Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293
D W+LGV+LYTLV G++PFDG + K L ++ G+YR P S D L++ L++NP +
Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291
Query: 294 RATIEDIANHWWVNWGYKSSVCD--CDALHDSESP------------------------- 326
R T+E I W+N G++ + L D + P
Sbjct: 292 RGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRY 351
Query: 327 --LLARIIDWHHRSTGLQADT-------EAKMKGLAKPTTSEVMLERQRSLKKSKKENDF 377
++A + ++S+ L+ DT A + + P+ S + QRS+ + K+ F
Sbjct: 352 NEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKV---QRSVSANPKQRRF 408
Query: 378 AQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCR 437
+ A+P S S + KR + S G ST K
Sbjct: 409 SDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRES----------GRKASSTAK------- 451
Query: 438 TGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVM 497
+P+SP +PG K + T +L +S RS +S LL+ +
Sbjct: 452 ----VPASP---LPGLERKKTTPTPSTNSVLS----------TSTNRSRNSPLLERASLG 494
Query: 498 GSSI------PSPSPPDPARVTSHSLS 518
+SI +P A ++H++S
Sbjct: 495 QASIQNGKDSTAPQRVPVASPSAHNIS 521
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 254 bits (649), Expect = 2e-67
Identities = 193/606 (31%), Positives = 288/606 (47%), Gaps = 91/606 (15%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y L +T+GKG + KVK A +G+ VA+K I K ++ + + + RE+ IM LNHP+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
I+ ++EV E + + ++MEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ +
Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
VHRDLK EN+LLD + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEV
Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293
D W+LGV+LYTLV G++PFDG + K L ++ G+YR P S D L++ L++NP +
Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291
Query: 294 RATIEDIANHWWVNWGYKSSVCD--CDALHDSESP------------------------- 326
R T+E I W+N G++ + L D + P
Sbjct: 292 RGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRY 351
Query: 327 --LLARIIDWHHRSTGLQADT-------EAKMKGLAKPTTSEVMLERQRSLKKSKKENDF 377
++A + ++S+ L+ DT A + + P+ S + QRS+ + K+ F
Sbjct: 352 NEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKV---QRSVSANPKQRRF 408
Query: 378 A-QSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLC 436
+ Q+ A+P S S + KR + S G ST K
Sbjct: 409 SDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRES----------GRKASSTAK------ 452
Query: 437 RTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDV 496
+P+SP +PG K + T +L +S RS +S LL+ +
Sbjct: 453 -----VPASP---LPGLERKKTTPTPSTNSVLS----------TSTNRSRNSPLLERASL 494
Query: 497 MGSSIPS-----PSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESL 551
+SI + P A S S + +H SA ++ P S PT +
Sbjct: 495 GQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSA-SVHPNKASGLPPTESNC 553
Query: 552 SEPGVPAEGLSRSYSRPSSV-ISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQI 610
P R + P V ++ S + S + N P RS A Q+
Sbjct: 554 EVP--------RPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQV 605
Query: 611 QDFEGL 616
+D + L
Sbjct: 606 RDQQNL 611
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 253 bits (647), Expect = 3e-67
Identities = 172/508 (33%), Positives = 258/508 (50%), Gaps = 82/508 (16%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y L +T+GKG + KVK A +G+ VA+K I K ++ + + + RE+ IM LNHP+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
I+ ++EV E + + ++MEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ +
Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
VHRDLK EN+LLD + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEV
Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293
D W+LGV+LYTLV G++PFDG + K L ++ G+YR P S D L++ L++NP +
Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291
Query: 294 RATIEDIANHWWVNWGYKSSVCD--CDALHDSESP------------------------- 326
R T+E I W+N G++ + L D + P
Sbjct: 292 RGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRY 351
Query: 327 --LLARIIDWHHRSTGLQADT-------EAKMKGLAKPTTSEVMLERQRSLKKSKKENDF 377
++A + ++S+ L+ DT A + + P+ S + QRS+ + K+ F
Sbjct: 352 NEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKV---QRSVSANPKQRRF 408
Query: 378 A-QSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLC 436
+ Q+ A+P S S + KR + S G ST K
Sbjct: 409 SDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRES----------GRKASSTAK------ 452
Query: 437 RTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDV 496
+P+SP +PG K + T +L +S RS +S LL+ +
Sbjct: 453 -----VPASP---LPGLERKKTTPTPSTNSVLS----------TSTNRSRNSPLLERASL 494
Query: 497 MGSSI------PSPSPPDPARVTSHSLS 518
+SI +P A ++H++S
Sbjct: 495 GQASIQNGKDSTAPQRVPVASPSAHNIS 522
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 252 bits (644), Expect = 7e-67
Identities = 125/258 (48%), Positives = 176/258 (68%), Gaps = 2/258 (0%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y LQ+T+GKG + KVK A +GR VA+K I K ++ + + + RE+ IM LNHP+
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKILNHPN 118
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
I+ ++EV E + + ++MEYAS GE++DY+ R+ E+E R FRQIVSAV YCH+ +
Sbjct: 119 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 178
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
VHRDLK EN+LLD + NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEV
Sbjct: 179 VHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEV 238
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293
D W+LGV+LYTLV G++PFDG + K L ++ G+YR P S D L++ +L++NP +
Sbjct: 239 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIK 298
Query: 294 RATIEDIANHWWVNWGYK 311
R ++E I W+N G++
Sbjct: 299 RGSLEQIMKDRWMNVGHE 316
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 251 bits (642), Expect = 1e-66
Identities = 125/274 (45%), Positives = 184/274 (67%), Gaps = 7/274 (2%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
YE+ T+GKG + VKRAT + VAIK I K ++ DE+++ I RE++IM L HPH
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPH 66
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
II +Y+V E + I ++ EYAS GE++D++ R++E+E R F+QIV+AV++CH +
Sbjct: 67 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
VHRDLK EN+LLD N NIKIADFG SNL+ + L+T+CGSP YA+PE+ G+ Y GP+V
Sbjct: 127 VHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKV 186
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293
D W+LGV+LY LV G +PFDG +NL ++ SG++R P ++ LIR ML+++P++
Sbjct: 187 DIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNK 246
Query: 294 RATIEDIANHWWVNWG-----YKSSVCDCDALHD 322
R ++E I H W+ G + + +C L +
Sbjct: 247 RLSMEQICKHKWMKLGDADPNFDRLIAECQQLKE 280
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 247 bits (630), Expect = 3e-65
Identities = 135/315 (42%), Positives = 192/315 (60%), Gaps = 22/315 (6%)
Query: 43 KRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRR 102
++H + + H Y L +TLG GT+GKVK +G VA+K + + KI+ + IRR
Sbjct: 16 QKHDGRVKIGH-YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
Query: 103 EIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQI 162
EI+ + HPHII +Y+V I ++MEY S GEL+DYI + RL E+E+R F+QI
Sbjct: 75 EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQI 134
Query: 163 VSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPE 222
+S V YCH++ VVHRDLK EN+LLD + N KIADFGLSN+ +FL+T CGSP YA+PE
Sbjct: 135 LSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 194
Query: 223 IVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP--TQPSDAR 280
+++GR Y GPEVD W+ GV+LY L+ GT+PFD L ++I G + P PS
Sbjct: 195 VISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS-VI 253
Query: 281 GLIRWMLMVNPDRRATIEDIANHWWVNW-----------GYKSSVCDCDALHD------- 322
L++ ML V+P +RATI+DI H W Y S++ D +AL +
Sbjct: 254 SLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFEC 313
Query: 323 SESPLLARIIDWHHR 337
SE +L+ + + +H+
Sbjct: 314 SEEEVLSCLYNRNHQ 328
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 247 bits (630), Expect = 3e-65
Identities = 121/253 (47%), Positives = 168/253 (66%), Gaps = 2/253 (0%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y+++ TLGKG + VK A R + VAIK I K ++ D ++ I RE+++M LNHPH
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL-DSSNLEKIYREVQLMKLLNHPH 85
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
II +Y+V E KD + I+ E+A GE++DY++ LSE E R F QI+SAV YCH + +
Sbjct: 86 IIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHI 145
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
VHRDLK EN+LLD N +IK+ADFG N Y+ + L T+CGSP YA+PE+ G+ Y GP++
Sbjct: 146 VHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQL 205
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293
D W+LGV+LY LV G++PFDG + L +++ G +R P D LIR ML+V+P R
Sbjct: 206 DIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPAR 265
Query: 294 RATIEDIANHWWV 306
R TI I H W+
Sbjct: 266 RITIAQIRQHRWM 278
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 241 bits (615), Expect = 2e-63
Identities = 125/282 (44%), Positives = 176/282 (62%), Gaps = 2/282 (0%)
Query: 43 KRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRR 102
++H + + H Y L +TLG GT+GKVK + +G VA+K + + KI+ + I+R
Sbjct: 5 QKHDGRVKIGH-YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63
Query: 103 EIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQI 162
EI+ + HPHII +Y+V ++MEY S GEL+DYI + R+ E E R F+QI
Sbjct: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 123
Query: 163 VSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPE 222
+SAV YCH++ VVHRDLK EN+LLD + N KIADFGLSN+ +FL+T CGSP YA+PE
Sbjct: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183
Query: 223 IVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARG 281
+++GR Y GPEVD W+ GV+LY L+ GT+PFD L ++I G + P +
Sbjct: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243
Query: 282 LIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDS 323
L+ ML V+P +RATI+DI H W S + D +D+
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDA 285
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 238 bits (608), Expect = 1e-62
Identities = 117/253 (46%), Positives = 165/253 (65%), Gaps = 2/253 (0%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y+++ TLGKG + VK R + VAIK I K ++ D ++ I RE++IM L+HPH
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL-DAVNLEKIYREVQIMKMLDHPH 78
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
II +Y+V E K + ++ EYA GE++DY++ RL+E E R F QI+SAV YCH +
Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
VHRDLK EN+LLD+N NIKIADFG N ++ + L T+CGSP YA+PE+ G+ Y GP++
Sbjct: 139 VHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQL 198
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293
D W++GV+LY LV G +PFDG L +++ G +R P D LIR ML+++P +
Sbjct: 199 DIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSK 258
Query: 294 RATIEDIANHWWV 306
R TI I H W+
Sbjct: 259 RLTIAQIKEHKWM 271
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 237 bits (604), Expect = 3e-62
Identities = 135/330 (40%), Positives = 192/330 (58%), Gaps = 37/330 (11%)
Query: 43 KRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRR 102
++H + + H Y L +TLG GT+GKVK +G VA+K + + KI+ + IRR
Sbjct: 16 QKHDGRVKIGH-YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74
Query: 103 EIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRR------------- 149
EI+ + HPHII +Y+V I ++MEY S GEL+DYI + R
Sbjct: 75 EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGST 134
Query: 150 --LSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDK 207
L E+E+R F+QI+S V YCH++ VVHRDLK EN+LLD + N KIADFGLSN+ +
Sbjct: 135 KELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE 194
Query: 208 FLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISS 267
FL+T CGSP YA+PE+++GR Y GPEVD W+ GV+LY L+ GT+PFD L ++I
Sbjct: 195 FLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICD 254
Query: 268 GEYREP--TQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNW-----------GYKSSV 314
G + P PS L++ ML V+P +RATI+DI H W Y S++
Sbjct: 255 GIFYTPQYLNPS-VISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTM 313
Query: 315 CDCDALHD-------SESPLLARIIDWHHR 337
D +AL + SE +L+ + + +H+
Sbjct: 314 IDDEALKEVCEKFECSEEEVLSCLYNRNHQ 343
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 233 bits (593), Expect = 6e-61
Identities = 110/267 (41%), Positives = 171/267 (64%), Gaps = 7/267 (2%)
Query: 45 HHHKHNLKHR-----YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVH 99
H H H +H Y L++TLGKG G VK +G+ VAIK + ++K+ E ++
Sbjct: 19 HPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLS-ESVLMK 77
Query: 100 IRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFF 159
+ REI I+ + HPH++ +++V+ENK + +++E+ S GEL+DY+ ++ RL+ +E R FF
Sbjct: 78 VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFF 137
Query: 160 RQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYA 219
RQIVSA+ +CH + HRDLK EN+LLD+ NI+IADFG+++L D L+T CGSP YA
Sbjct: 138 RQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYA 197
Query: 220 SPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSD 278
PE++ G Y G D W+ GV+L+ L+ G +PFD + + L+ ++ G + P P D
Sbjct: 198 CPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPD 257
Query: 279 ARGLIRWMLMVNPDRRATIEDIANHWW 305
+ L+R M+ V P++R ++E I H W
Sbjct: 258 CQSLLRGMIEVEPEKRLSLEQIQKHPW 284
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 225 bits (573), Expect = 1e-58
Identities = 105/252 (41%), Positives = 166/252 (65%), Gaps = 2/252 (0%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y L++TLGKG G VK + + VAIK + ++K+ E ++ + REI I+ + HPH
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLS-ESVLMKVEREIAILKLIEHPH 77
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
++ +++V+ENK + +++E+ S GEL+DY+ ++ RL+ +E R FFRQI+SA+ +CH + +
Sbjct: 78 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 137
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
HRDLK EN+LLD+ NI+IADFG+++L D L+T CGSP YA PE++ G Y G +
Sbjct: 138 CHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKA 197
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293
D W+ GV+L+ L+ G +PFD + + L+ ++ G + P P D + L+R M+ V+ R
Sbjct: 198 DVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAAR 257
Query: 294 RATIEDIANHWW 305
R T+E I H W
Sbjct: 258 RLTLEHIQKHIW 269
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 213 bits (542), Expect = 5e-55
Identities = 116/264 (43%), Positives = 161/264 (60%), Gaps = 7/264 (2%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
YEL ET+G G + KVK A +G +VAIK + K+ + D+ I+ EIE + +L H H
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLRHQH 68
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
I +Y V E +KI +++EY GEL+DYI + RLSE ETR FRQIVSAV Y H G
Sbjct: 69 ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 128
Query: 175 VHRDLKLENILLDDNCNIKIADFGL--SNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGP 232
HRDLK EN+L D+ +K+ DFGL KD LQT CGS YA+PE++ G+ Y G
Sbjct: 129 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
Query: 233 EVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP--TQPSDARGLIRWMLMVN 290
E D W++G+LLY L+ G +PFD + L ++I G+Y P PS L++ ML V+
Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSIL-LLQQMLQVD 247
Query: 291 PDRRATIEDIANHWWVNWGYKSSV 314
P +R +++++ NH W+ Y V
Sbjct: 248 PKKRISMKNLLNHPWIMQDYNYPV 271
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 192 bits (489), Expect = 6e-49
Identities = 107/253 (42%), Positives = 146/253 (57%), Gaps = 2/253 (0%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y ++ +G G + +VK + VAIK + K K+ D++ + REI M L+HP+
Sbjct: 74 YRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKL-DQKTQRLLSREISSMEKLHHPN 132
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
II +YEV E K+ ++MEYA GEL+ IS +LSE E++ F QIVSAV + H+N +
Sbjct: 133 IIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHENQI 192
Query: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
+HRDLK EN+ N +K+ DFG S + +K + L TFCGSP YA+PE+ Y G V
Sbjct: 193 IHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGIYV 252
Query: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSD-ARGLIRWMLMVNPDR 293
D WALGVLLY +V GTMPF L + I G Y P S+ LIR +L P
Sbjct: 253 DIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIPTE 312
Query: 294 RATIEDIANHWWV 306
R I+ I N W+
Sbjct: 313 RYGIDCIMNDEWM 325
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 190 bits (483), Expect = 3e-48
Identities = 103/255 (40%), Positives = 153/255 (60%), Gaps = 4/255 (1%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y+L +TLG+G + VK A F+G VA+K I K K+ D H+ +E+ M + HP+
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKL-DTLATGHLFQEVRCMKLVQHPN 74
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRR-LSERETRHFFRQIVSAVHYCHKNG 173
I+ +YEV + + K+ +I+E G+++DYI + L+E + +F QIV A+ YCHK
Sbjct: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134
Query: 174 VVHRDLKLENILLDDNCN-IKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGP 232
VVHRDLK EN++ + +K+ DFG SN +Q K L T CGS Y++PEI+ G Y P
Sbjct: 135 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 194
Query: 233 EVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNP 291
VD W+LGV+L+ LV G PF + + I +Y P+ S + + LI ML +P
Sbjct: 195 AVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDP 254
Query: 292 DRRATIEDIANHWWV 306
RRA++E+I NH W+
Sbjct: 255 KRRASLEEIENHPWL 269
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 190 bits (483), Expect = 3e-48
Identities = 103/255 (40%), Positives = 153/255 (60%), Gaps = 4/255 (1%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Y+L +TLG+G + VK A F+G VA+K I K K+ D H+ +E+ M + HP+
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKL-DTLATGHLFQEVRCMKLVQHPN 74
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRR-LSERETRHFFRQIVSAVHYCHKNG 173
I+ +YEV + + K+ +I+E G+++DYI + L+E + +F QIV A+ YCHK
Sbjct: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134
Query: 174 VVHRDLKLENILLDDNCN-IKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGP 232
VVHRDLK EN++ + +K+ DFG SN +Q K L T CGS Y++PEI+ G Y P
Sbjct: 135 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 194
Query: 233 EVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNP 291
VD W+LGV+L+ LV G PF + + I +Y P+ S + + LI ML +P
Sbjct: 195 AVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDP 254
Query: 292 DRRATIEDIANHWWV 306
RRA++E+I NH W+
Sbjct: 255 KRRASLEEIENHPWL 269
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 183 bits (464), Expect = 5e-46
Identities = 95/251 (37%), Positives = 152/251 (60%), Gaps = 3/251 (1%)
Query: 46 HHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIE 105
HHK + ++ + LGKGT+GKV E+ SG+ A+K ++K+ I + ++ H E
Sbjct: 139 HHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESR 198
Query: 106 IMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSA 165
++ + HP + S+ F+ KD++ +MEY + GEL+ ++S R SE TR + +IVSA
Sbjct: 199 VLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSA 258
Query: 166 VHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKD-KFLQTFCGSPLYASPEIV 224
+ Y H +V+RDLKLEN++LD + +IKI DFGL D ++TFCG+P Y +PE++
Sbjct: 259 LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL 318
Query: 225 NGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLI 283
Y G VD W LGV++Y ++ G +PF DH+ L I + + P T SDA+ L+
Sbjct: 319 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 284 RWMLMVNPDRR 294
+L+ +P++R
Sbjct: 378 SGLLIKDPNKR 388
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 183 bits (464), Expect = 5e-46
Identities = 95/251 (37%), Positives = 152/251 (60%), Gaps = 3/251 (1%)
Query: 46 HHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIE 105
HHK + ++ + LGKGT+GKV E+ SG+ A+K ++K+ I + ++ H E
Sbjct: 139 HHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESR 198
Query: 106 IMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSA 165
++ + HP + S+ F+ KD++ +MEY + GEL+ ++S R SE TR + +IVSA
Sbjct: 199 VLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSA 258
Query: 166 VHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKD-KFLQTFCGSPLYASPEIV 224
+ Y H +V+RDLKLEN++LD + +IKI DFGL D ++TFCG+P Y +PE++
Sbjct: 259 LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL 318
Query: 225 NGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLI 283
Y G VD W LGV++Y ++ G +PF DH+ L I + + P T SDA+ L+
Sbjct: 319 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 284 RWMLMVNPDRR 294
+L+ +P++R
Sbjct: 378 SGLLIKDPNKR 388
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 179 bits (454), Expect = 7e-45
Identities = 139/483 (28%), Positives = 227/483 (46%), Gaps = 43/483 (8%)
Query: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
+++ LGKG++ V RA +G VAIK I K + + ++ E++I L HP
Sbjct: 12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 71
Query: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISER-RRLSERETRHFFRQIVSAVHYCHKNG 173
I+ +Y FE+ + + +++E GE+ Y+ R + SE E RHF QI++ + Y H +G
Sbjct: 72 ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHG 131
Query: 174 VVHRDLKLENILLDDNCNIKIADFGL-SNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGP 232
++HRDL L N+LL N NIKIADFGL + L + T CG+P Y SPEI R G
Sbjct: 132 ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIAT-RSAHGL 190
Query: 233 EVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNP 291
E D W+LG + YTL+ G PFD KN + ++ +Y P+ S +A+ LI +L NP
Sbjct: 191 ESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNP 250
Query: 292 DRRATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHR--STGLQADTEAKM 349
R ++ + +H +++ + D + DS ID H ST + A + +
Sbjct: 251 ADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDS--------IDSGHATISTAITASSSTSI 302
Query: 350 KG----LAKPTTSEVMLERQRSLKKSKKENDFAQSG-----------QDAVPESPSKL-- 392
G + + + + K+K DF+ SG Q+ ++
Sbjct: 303 SGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRVIQ 362
Query: 393 -SSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAEVP 451
+ +RP +R+ S RS ++ + T+ ME+ C + +L S +
Sbjct: 363 DAEERPHSRYLRRAYSSDRSGTSN------SQSQAKTYTMER--CHSAEMLSVSKRSG-G 413
Query: 452 GKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSP-SPPDPA 510
G+ + S T I +++ S S ER ++++ L SN + P P + P P
Sbjct: 414 GENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQAL-SNHLCPGKTPFPFADPTPQ 472
Query: 511 RVT 513
T
Sbjct: 473 TET 475
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 179 bits (453), Expect = 9e-45
Identities = 108/266 (40%), Positives = 150/266 (56%), Gaps = 10/266 (3%)
Query: 51 LKHR-YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSS 109
LK R Y L LG+G+Y KVK A VAIK I + K + + REIEI++
Sbjct: 7 LKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAM 66
Query: 110 LNHPHIISIYEVFENKD-KIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHY 168
LNH II YE+FE K+ I+ME A +G+L + I R L E E R F Q+ A+ Y
Sbjct: 67 LNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKY 126
Query: 169 CHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKD-----KFLQTFCGSPLYASPEI 223
CH VVHRDLK +N+LLD + NIK++DF S +D +TFCGSP YA+PE+
Sbjct: 127 CHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEV 186
Query: 224 VNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ---PSDAR 280
+ G PY+ D W+LGV+LY +V G+MP+D + K ++R P + +
Sbjct: 187 LQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECK 246
Query: 281 GLIRWMLMVNPDRRATIEDIANHWWV 306
LI ML + +RR I++I +H W+
Sbjct: 247 DLIYHMLQPDVNRRLHIDEILSHCWM 272
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 177 bits (450), Expect = 2e-44
Identities = 116/317 (36%), Positives = 177/317 (55%), Gaps = 19/317 (5%)
Query: 13 PDLGLGAPGSPREAVAGATAALEPRKPHGVKRH------HHKHNLKHRYELQETLGKGTY 66
P G GA + R A A + L P GV R HHK + ++ LG+G++
Sbjct: 16 PGGGGGAEDAARPAAACEGSFL-PAWVSGVPRERLRDFQHHKRVGNYLIGSRK-LGEGSF 73
Query: 67 GKVKRATERFSGRVVAIKSIRKDKIKDEQDMV-HIRREIEIMSSLNHPHIISIYEVFENK 125
KV+ +G VAIK I K + K + + ++RRE +I + HP+I + ++ E +
Sbjct: 74 AKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETE 133
Query: 126 DKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENIL 185
+ ++ME G L I E++RL E E R + RQ++SAV + H+ GVVHRDLK+EN+L
Sbjct: 134 NSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLL 193
Query: 186 LDDNCNIKIADFGLSN----LYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGV 241
LD++ NIK+ DFGLSN L D F T CGSP YA+PE++ + Y GP++D W++GV
Sbjct: 194 LDEDNNIKLIDFGLSNCAGILGYSDPF-STQCGSPAYAAPELLARKKY-GPKIDVWSIGV 251
Query: 242 LLYTLVYGTMPF--DGFDHKNLIRQISSGEYRE-PTQPS-DARGLIRWMLMVNPDRRATI 297
+Y ++ GT+PF + F + L +++ E PTQ S A +R +L +P +R I
Sbjct: 252 NMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNI 311
Query: 298 EDIANHWWVNWGYKSSV 314
+ + W+N Y V
Sbjct: 312 QQALANRWLNENYTGKV 328
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,164,194
Number of Sequences: 37866
Number of extensions: 1347812
Number of successful extensions: 8291
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 749
Number of HSP's successfully gapped in prelim test: 190
Number of HSP's that attempted gapping in prelim test: 5479
Number of HSP's gapped (non-prelim): 1384
length of query: 661
length of database: 18,247,518
effective HSP length: 109
effective length of query: 552
effective length of database: 14,120,124
effective search space: 7794308448
effective search space used: 7794308448
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.