Search of human proteins with 7661636

Search of human proteins with 7661636

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7661636 SYF2 homolog, RNA splicing factor isoform 1 [Homo
sapiens]
         (243 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7661636 SYF2 homolog, RNA splicing factor isoform 1 [Homo sap...   485   e-137
gi|46371998 SYF2 homolog, RNA splicing factor isoform 2 [Homo sa...   380   e-106
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]        44   2e-04
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            43   3e-04
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            42   6e-04
gi|224458301 family with sequence similarity 186, member A [Homo...    41   8e-04
gi|221219020 NYD-SP11 protein [Homo sapiens]                           40   0.001
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                40   0.002
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    40   0.002
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    40   0.002
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    40   0.002
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    40   0.002
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]          40   0.002
gi|148746195 trichohyalin [Homo sapiens]                               40   0.002
gi|13569843 nucleolar protein 7, 27kDa [Homo sapiens]                  40   0.002
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    39   0.003
gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo sap...    39   0.003
gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]    39   0.003
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    39   0.004
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    39   0.004
gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]    39   0.005
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        39   0.005
gi|92859701 myosin VI [Homo sapiens]                                   38   0.007
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    38   0.009
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           38   0.009
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           38   0.009
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           38   0.009
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    38   0.009
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    38   0.009
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       38   0.009

>gi|7661636 SYF2 homolog, RNA splicing factor isoform 1 [Homo
           sapiens]
          Length = 243

 Score =  485 bits (1248), Expect = e-137
 Identities = 243/243 (100%), Positives = 243/243 (100%)

Query: 1   MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDK 60
           MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDK
Sbjct: 1   MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDK 60

Query: 61  RLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNP 120
           RLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNP
Sbjct: 61  RLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNP 120

Query: 121 DLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEID 180
           DLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEID
Sbjct: 121 DLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEID 180

Query: 181 RMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERG 240
           RMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERG
Sbjct: 181 RMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERG 240

Query: 241 TAV 243
           TAV
Sbjct: 241 TAV 243


>gi|46371998 SYF2 homolog, RNA splicing factor isoform 2 [Homo
           sapiens]
          Length = 201

 Score =  380 bits (975), Expect = e-106
 Identities = 201/243 (82%), Positives = 201/243 (82%), Gaps = 42/243 (17%)

Query: 1   MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDK 60
           MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMR                
Sbjct: 1   MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMR---------------- 44

Query: 61  RLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNP 120
                                     ECAARGEDYEKVKLLEISAEDAERWERKKKRKNP
Sbjct: 45  --------------------------ECAARGEDYEKVKLLEISAEDAERWERKKKRKNP 78

Query: 121 DLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEID 180
           DLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEID
Sbjct: 79  DLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEID 138

Query: 181 RMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERG 240
           RMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERG
Sbjct: 139 RMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERG 198

Query: 241 TAV 243
           TAV
Sbjct: 199 TAV 201


>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
          Length = 495

 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 46/174 (26%), Positives = 77/174 (44%), Gaps = 17/174 (9%)

Query: 20  AAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWEL 79
           A  AE  A K EQ  R       M  E +++  +E   EDKR K  A +      LE +L
Sbjct: 139 AQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD---LEKQL 195

Query: 80  KEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLT 139
           +E+EKKK+ A      EK+ + EI  +  E  + +K++K             L + + + 
Sbjct: 196 EEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQK-------------LEKMNAMR 242

Query: 140 KQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKR 193
           + I+   +     R+K  EE    +  ++   ++    E DRM   +++  EKR
Sbjct: 243 RYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMA-KVQENEEKR 295



 Score = 41.2 bits (95), Expect = 8e-04
 Identities = 49/225 (21%), Positives = 102/225 (45%), Gaps = 29/225 (12%)

Query: 24  ELAAQKREQRLRKFRELHLMRNEARKLNHQEVV---EEDKRLK-LPANWEAKKARLEWEL 79
           ++   + + R+++ + L L++NE  +L+ +E +   EE+KRLK L    E K A    +L
Sbjct: 41  QMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKL 100

Query: 80  KEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLT 139
           K E  K E   +      ++L E+  +    +  K++            AAQ+ +   + 
Sbjct: 101 KHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKER------------AAQIAEKDAIK 148

Query: 140 -KQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSR 198
            +Q+K D E  + + E+H +      N+     +    +      +DLEKQ+E+++K  +
Sbjct: 149 YEQMKRDAEIAKTMMEEH-KRIIKEENAAEDKRNKAKAQ----YYLDLEKQLEEQEK-KK 202

Query: 199 RRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERGTAV 243
           +  Y      + + +     ++   + Y +   E +Q LE+  A+
Sbjct: 203 QEAY------EQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAM 241



 Score = 27.7 bits (60), Expect = 9.4
 Identities = 33/159 (20%), Positives = 63/159 (39%), Gaps = 18/159 (11%)

Query: 15  EEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKAR 74
           E   +   A +  Q+ E R+ K +E     NE ++L  Q  + +     L    + ++ R
Sbjct: 266 ENRKIIEFANMQQQREEDRMAKVQE-----NEEKRLQLQNALTQKLEEMLRQREDLEQVR 320

Query: 75  LEW-----------ELKEEEKKK--ECAARGEDYEKVKLLEISAEDAERWERKKKRKNPD 121
            E            +LKEE +KK  +     +D+E+   L+     A + E +  RK   
Sbjct: 321 QELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTML 380

Query: 122 LGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEF 160
             F++    +L    +   +        E+L E+  ++F
Sbjct: 381 AKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQF 419


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 47/219 (21%), Positives = 89/219 (40%), Gaps = 24/219 (10%)

Query: 11  VDSAEEGSLAAAAELAAQKREQRLRKF-RELHLMRNEARKLNHQEVVEEDKRLKLPANWE 69
           +++ +EG     +E   ++RE+  RK  RE    R   +K    E  +E++  K      
Sbjct: 45  IETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERK---KRR 101

Query: 70  AKKARLEWELKEEEKKKECAARG----EDYEKVKLLEISAEDAERWERKKKRKNPDLGFS 125
            +K   E E KE+ KKKE   RG    E  E+ +  E   E+ +  ERKK+ +  +    
Sbjct: 102 REKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERK 161

Query: 126 DYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVID 185
           +    + +Q     ++ K       + RE++ +E                 E  +R    
Sbjct: 162 ERKKRERKQVGEKEEERKEKERKERKKRERNRKE------------RKKERERKERR--- 206

Query: 186 LEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAER 224
            E++ E++ K  R++    D   ++  +   K  +K  +
Sbjct: 207 -ERKKERKKKEERKKERQKDRQTNWREKERGKRERKERK 244



 Score = 30.4 bits (67), Expect = 1.5
 Identities = 44/197 (22%), Positives = 82/197 (41%), Gaps = 13/197 (6%)

Query: 28  QKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKE 87
           ++RE+ +   +E    R   RK   +E  E +KR K     E K+ R + E K E KK+E
Sbjct: 39  REREREIETRKEGKKERESERK---KERREREKR-KREREKERKRERGKKEKKGERKKEE 94

Query: 88  CAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPDME 147
              +    EK        E+ E+  +KK++K          + + ++  R  ++ + + +
Sbjct: 95  RERKKRRREKENK---EGEEKEK-RKKKEKKE-----RGRTSKEGKERERKEERKREERK 145

Query: 148 TYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYNDDAD 207
             ER +E+  +E             V   EE  +     E++  +R++  R++       
Sbjct: 146 ERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKER 205

Query: 208 IDYINERNAKFNKKAER 224
            +   ER  K  +K ER
Sbjct: 206 RERKKERKKKEERKKER 222


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 42/188 (22%), Positives = 77/188 (40%), Gaps = 15/188 (7%)

Query: 24  ELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEE 83
           E   +KRE+   + RE      + RK   +    E KR +     + ++ +   + K+E+
Sbjct: 42  EREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEK 101

Query: 84  KKKECAARG--EDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQ 141
           KK+E   RG  E  +K +  E   E+ +R ERK+K++              ++  R  ++
Sbjct: 102 KKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR-------------KKKRRKERK 148

Query: 142 IKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRP 201
            + +    ER R+K  +E                 E  +R     E++ E+R K  R++ 
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKD 208

Query: 202 YNDDADID 209
              D   D
Sbjct: 209 RKTDRQTD 216


>gi|224458301 family with sequence similarity 186, member A [Homo
           sapiens]
          Length = 2351

 Score = 41.2 bits (95), Expect = 8e-04
 Identities = 42/179 (23%), Positives = 89/179 (49%), Gaps = 15/179 (8%)

Query: 24  ELAAQKREQRLRKFRE-LHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEE 82
           E   Q++EQ L++ +E +  M  + + L  + +++E    K+  NWE KKA L+ +  ++
Sbjct: 817 EKEKQRQEQYLQEGQEQMSGMSLKQQLLGERNLLKEHYE-KISENWEEKKAWLQMKEGKQ 875

Query: 83  EKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQI 142
           E++ +   + E+  K +  + + + AE+ E++K+R   +    +   + L++    T++ 
Sbjct: 876 EQQSQKQWQEEEMWKEEQKQATPKQAEQEEKQKQRGQEE---EELPKSSLQRLEEGTQK- 931

Query: 143 KPDMETYERLREKHGEEFFPTSNSLLH-GTH-----VPSTEEIDRMVIDLEKQIEKRDK 195
              M+T   L EK   +         H G H         ++ +R + DLE+QI+ +D+
Sbjct: 932 ---MKTQGLLLEKENGQMRQIQKEAKHLGPHRRREKGKEKQKPERGLEDLERQIKTKDQ 987


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 40.4 bits (93), Expect = 0.001
 Identities = 45/196 (22%), Positives = 82/196 (41%), Gaps = 26/196 (13%)

Query: 7    SEVLVDSAEEGSLAAAAELAAQKREQRLRKF-----RELHLMRNEARKLNHQEVVEEDKR 61
            SEV++D  EEG +     +   KR  R RK      +      ++  ++  +E   E+  
Sbjct: 2172 SEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEME 2231

Query: 62   LKLPA--NWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKN 119
              L      E+  +  E E +EEE+++E   R E+ E+ +  E   +  E+ E +KK+K 
Sbjct: 2232 SLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKK 2291

Query: 120  PDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEI 179
             +               +  ++++   E +E   E   EE   + +         S EE 
Sbjct: 2292 KE---------------KKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEE- 2335

Query: 180  DRMVIDLEKQIEKRDK 195
                +D EK+I K++K
Sbjct: 2336 ---EVDREKEILKKEK 2348



 Score = 34.3 bits (77), Expect = 0.10
 Identities = 46/201 (22%), Positives = 84/201 (41%), Gaps = 12/201 (5%)

Query: 27   AQKREQRLRKFRELHLMRNEARKLN-HQEVVEEDKRLKLPANWEAKKARLEWELKEEEKK 85
            A K E   R  +E   +     KL+  +E+++EDK+LK    WE  K    WE     K 
Sbjct: 1480 AWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLK----WEEWKQ--VWENMLSSKS 1533

Query: 86   KECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPD 145
            KE   + +D E+V L E  + + E  E++   +   +      A   R+  R  K+   +
Sbjct: 1534 KE--QQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQE 1591

Query: 146  METYERLREKHGEE--FFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYN 203
                 +  EK  +E          L   +V  T++ DR +   E +  ++++   +R   
Sbjct: 1592 ERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQD-DREMAQAEGKFAQKEETLAQRGEK 1650

Query: 204  DDADIDYINERNAKFNKKAER 224
               + + + ++  K  KK E+
Sbjct: 1651 LSQEAEKLAQKRKKLAKKWEK 1671



 Score = 30.8 bits (68), Expect = 1.1
 Identities = 49/225 (21%), Positives = 87/225 (38%), Gaps = 22/225 (9%)

Query: 16   EGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARL 75
            EG  A   E  AQ+ E+  ++  +L   R +  K   ++V  E+++L       A+   +
Sbjct: 1634 EGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAK-KWEKVAREEEKLAKKGGKLAEVKNI 1692

Query: 76   EWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQY 135
              +  EE  ++E     ++ E  + LE    D E    K++  N + G            
Sbjct: 1693 LAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEG------------ 1740

Query: 136  HRLTKQIKPDMETYERL---REKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEK 192
             +L ++ K   E  E L   REK  EE      + L        +E +++    EK  E+
Sbjct: 1741 -KLVEEKKKLAEEEEALAWQREKLSEE-----ETKLAQEEELLIQEKEKLAQHKEKMPEE 1794

Query: 193  RDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNL 237
             ++  R+R    +  +    +R    N   E    K     K+NL
Sbjct: 1795 EERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNL 1839



 Score = 30.0 bits (66), Expect = 1.9
 Identities = 45/230 (19%), Positives = 93/230 (40%), Gaps = 32/230 (13%)

Query: 19   LAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQE---VVEEDKRLKLPANWEAKKARL 75
            LA A+    +KRE   ++  +L+ +    +KL   E     EE K  K+      K+ RL
Sbjct: 2052 LAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRL 2111

Query: 76   ----------EWELKEE------EKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKN 119
                      EW+  E+      ++KK    + +   K++ +    E     E K  RK+
Sbjct: 2112 SIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKH 2171

Query: 120  PDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLR------EKHGEEFFPTSNSLLHGTHV 173
             ++   D     + +     +++ P ++   R R      +K  E+F    + +    H 
Sbjct: 2172 SEVILDDEEEGGIEE-----EEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHF 2226

Query: 174  PSTEEIDRMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAE 223
              +EE++ ++ +LEKQ     +    R   ++ + + + E   +  ++ E
Sbjct: 2227 --SEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEE 2274


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 54/221 (24%), Positives = 89/221 (40%), Gaps = 43/221 (19%)

Query: 28  QKREQRLRKFRELHLMRNEARKLNHQEVVEEDK-------------RLKLPANWEAKKAR 74
           ++RE+   + RE    R   R+   +   E+DK             R KL      K+A 
Sbjct: 397 REREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAA 456

Query: 75  LE-----WELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDY-A 128
            +     WE++E +K +E       YEK    E   E+  R E  K+ K       DY  
Sbjct: 457 YQERLKNWEIRERKKTRE-------YEK----EAEREEERRREMAKEAKRLKEFLEDYDD 505

Query: 129 AAQLRQYHR---LTKQIK---PDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRM 182
                +Y+R   L K+++    +ME  ER R++  EE       LL   H     E+ RM
Sbjct: 506 DRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRM 565

Query: 183 VIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAE 223
             + E+   +R    ++ P +++ +     E+  K  K+ E
Sbjct: 566 EQEAER---RRQPQIKQEPESEEEE----EEKQEKEEKREE 599



 Score = 39.7 bits (91), Expect = 0.002
 Identities = 52/228 (22%), Positives = 96/228 (42%), Gaps = 26/228 (11%)

Query: 17  GSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPAN-WEAKKARL 75
           G L A      ++ E  LR  R LH ++   +KL    +V+ D + K   + W+AKK   
Sbjct: 124 GKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKL----LVKVDAKTKAQLDEWKAKKKAS 179

Query: 76  -------------EWELKEEEKKKECAARGEDYEKVKLLEISAE------DAERWERKKK 116
                        E  L EE K+++   +G    +V + E S+E      +++   RKKK
Sbjct: 180 NGNARPETVTNDDEEALDEETKRRDQMIKGAI--EVLIREYSSELNAPSQESDSHPRKKK 237

Query: 117 RKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPST 176
           ++  +  F  +  A L  Y  +TK+    +E  E  R+    E     ++          
Sbjct: 238 KEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGK 297

Query: 177 EEIDRMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAER 224
           +E +R  I+ E++  +R++   R     + + +   ER  +  ++ ER
Sbjct: 298 KEKERQEIEKERRERERERERERERREREREREREREREKEKERERER 345



 Score = 32.7 bits (73), Expect = 0.29
 Identities = 51/221 (23%), Positives = 86/221 (38%), Gaps = 41/221 (18%)

Query: 22  AAELAAQKRE---QRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWE 78
           A E+   KR+   + + KFR+ H      +KL      EE+K  K     E +K R E E
Sbjct: 266 AIEMEEDKRDLISREISKFRDTH------KKL------EEEKGKKEKERQEIEKERRERE 313

Query: 79  LKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRL 138
            +E E+++E   R  + E+ +  E   E     ER + R                     
Sbjct: 314 -RERERERERREREREREREREREKEKERERERERDRDRDR------------------- 353

Query: 139 TKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSR 198
           TK+   D +  ER R++  E     +             E +R     E++ E+  +  R
Sbjct: 354 TKERDRDRDR-ERDRDRDRERSSDRNKDRSRSREKSRDRERER-----ERERERERERER 407

Query: 199 RRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLER 239
            R    + + +   ER  + +KK +R   +  A  ++ LER
Sbjct: 408 EREREREREREREREREREKDKKRDREEDEEDAYERRKLER 448



 Score = 28.9 bits (63), Expect = 4.2
 Identities = 25/133 (18%), Positives = 60/133 (45%), Gaps = 6/133 (4%)

Query: 30  REQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKECA 89
           RE+   + RE    RN+ R  + ++  + ++  +     E ++ R     +E E+++E  
Sbjct: 363 RERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERE-- 420

Query: 90  ARGEDYEKVKLLEISAEDAERWERKK---KRKNPDLGFSDYAAAQLRQYHRLTKQIKPDM 146
            R  + EK K  +   ++ + +ER+K   K +  +  + +       +  + T++ + + 
Sbjct: 421 -REREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEA 479

Query: 147 ETYERLREKHGEE 159
           E  E  R +  +E
Sbjct: 480 EREEERRREMAKE 492


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 35/150 (23%), Positives = 73/150 (48%), Gaps = 13/150 (8%)

Query: 15  EEGSLAAAAELAAQKREQRLRKFRELHL-MRNEARKLNHQEVVEEDKRLKLPANWEAKKA 73
           EE       ELA +K+E+ LR+ RE  + +R +  +   Q+  E  +RL+     E ++ 
Sbjct: 769 EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 828

Query: 74  RLEWELKEEEKKKECAARGEDYEKVKL----LEISAEDAERWERKKKRKNPDLGFSDYAA 129
           + E  L+++E++    AR E+  + +L    L +  E A     +++RK  +L       
Sbjct: 829 KQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKEL------- 881

Query: 130 AQLRQYHRLTKQIKPDMETYERLREKHGEE 159
            ++++   L +Q +   E   RL+++  ++
Sbjct: 882 -EVQRQKELMRQRQQQQEALRRLQQQQQQQ 910



 Score = 36.6 bits (83), Expect = 0.020
 Identities = 38/171 (22%), Positives = 77/171 (45%), Gaps = 16/171 (9%)

Query: 5   AASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRE--LHLMRNEARKLNHQEVVEEDKRL 62
           A +  L     E  + A  E   +KR++ LR+ +E  L   + E RK   +E +   K+ 
Sbjct: 726 AKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 785

Query: 63  KLPANWEAKKARLEWELKEEEKKKECAA-------RGEDYEKVK---LLEISAEDAERWE 112
           +       ++  L  + +EEE++++  A       R E+ E+ K   LL    E+A +W 
Sbjct: 786 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWA 845

Query: 113 RKKKRKNPDLGFS----DYAAAQLRQYHRLTKQIKPDMETYERLREKHGEE 159
           R+++     L  +    +  AA+LR      K+ + +++  + L  +  ++
Sbjct: 846 REEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 896


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 35/150 (23%), Positives = 73/150 (48%), Gaps = 13/150 (8%)

Query: 15  EEGSLAAAAELAAQKREQRLRKFRELHL-MRNEARKLNHQEVVEEDKRLKLPANWEAKKA 73
           EE       ELA +K+E+ LR+ RE  + +R +  +   Q+  E  +RL+     E ++ 
Sbjct: 796 EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 855

Query: 74  RLEWELKEEEKKKECAARGEDYEKVKL----LEISAEDAERWERKKKRKNPDLGFSDYAA 129
           + E  L+++E++    AR E+  + +L    L +  E A     +++RK  +L       
Sbjct: 856 KQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKEL------- 908

Query: 130 AQLRQYHRLTKQIKPDMETYERLREKHGEE 159
            ++++   L +Q +   E   RL+++  ++
Sbjct: 909 -EVQRQKELMRQRQQQQEALRRLQQQQQQQ 937



 Score = 36.6 bits (83), Expect = 0.020
 Identities = 38/171 (22%), Positives = 77/171 (45%), Gaps = 16/171 (9%)

Query: 5   AASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRE--LHLMRNEARKLNHQEVVEEDKRL 62
           A +  L     E  + A  E   +KR++ LR+ +E  L   + E RK   +E +   K+ 
Sbjct: 753 AKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 812

Query: 63  KLPANWEAKKARLEWELKEEEKKKECAA-------RGEDYEKVK---LLEISAEDAERWE 112
           +       ++  L  + +EEE++++  A       R E+ E+ K   LL    E+A +W 
Sbjct: 813 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWA 872

Query: 113 RKKKRKNPDLGFS----DYAAAQLRQYHRLTKQIKPDMETYERLREKHGEE 159
           R+++     L  +    +  AA+LR      K+ + +++  + L  +  ++
Sbjct: 873 REEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 923


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 35/150 (23%), Positives = 73/150 (48%), Gaps = 13/150 (8%)

Query: 15  EEGSLAAAAELAAQKREQRLRKFRELHL-MRNEARKLNHQEVVEEDKRLKLPANWEAKKA 73
           EE       ELA +K+E+ LR+ RE  + +R +  +   Q+  E  +RL+     E ++ 
Sbjct: 775 EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 834

Query: 74  RLEWELKEEEKKKECAARGEDYEKVKL----LEISAEDAERWERKKKRKNPDLGFSDYAA 129
           + E  L+++E++    AR E+  + +L    L +  E A     +++RK  +L       
Sbjct: 835 KQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKEL------- 887

Query: 130 AQLRQYHRLTKQIKPDMETYERLREKHGEE 159
            ++++   L +Q +   E   RL+++  ++
Sbjct: 888 -EVQRQKELMRQRQQQQEALRRLQQQQQQQ 916



 Score = 36.6 bits (83), Expect = 0.020
 Identities = 38/171 (22%), Positives = 77/171 (45%), Gaps = 16/171 (9%)

Query: 5   AASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRE--LHLMRNEARKLNHQEVVEEDKRL 62
           A +  L     E  + A  E   +KR++ LR+ +E  L   + E RK   +E +   K+ 
Sbjct: 732 AKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 791

Query: 63  KLPANWEAKKARLEWELKEEEKKKECAA-------RGEDYEKVK---LLEISAEDAERWE 112
           +       ++  L  + +EEE++++  A       R E+ E+ K   LL    E+A +W 
Sbjct: 792 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWA 851

Query: 113 RKKKRKNPDLGFS----DYAAAQLRQYHRLTKQIKPDMETYERLREKHGEE 159
           R+++     L  +    +  AA+LR      K+ + +++  + L  +  ++
Sbjct: 852 REEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 902


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 35/150 (23%), Positives = 73/150 (48%), Gaps = 13/150 (8%)

Query: 15  EEGSLAAAAELAAQKREQRLRKFRELHL-MRNEARKLNHQEVVEEDKRLKLPANWEAKKA 73
           EE       ELA +K+E+ LR+ RE  + +R +  +   Q+  E  +RL+     E ++ 
Sbjct: 775 EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 834

Query: 74  RLEWELKEEEKKKECAARGEDYEKVKL----LEISAEDAERWERKKKRKNPDLGFSDYAA 129
           + E  L+++E++    AR E+  + +L    L +  E A     +++RK  +L       
Sbjct: 835 KQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKEL------- 887

Query: 130 AQLRQYHRLTKQIKPDMETYERLREKHGEE 159
            ++++   L +Q +   E   RL+++  ++
Sbjct: 888 -EVQRQKELMRQRQQQQEALRRLQQQQQQQ 916



 Score = 36.6 bits (83), Expect = 0.020
 Identities = 38/171 (22%), Positives = 77/171 (45%), Gaps = 16/171 (9%)

Query: 5   AASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRE--LHLMRNEARKLNHQEVVEEDKRL 62
           A +  L     E  + A  E   +KR++ LR+ +E  L   + E RK   +E +   K+ 
Sbjct: 732 AKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 791

Query: 63  KLPANWEAKKARLEWELKEEEKKKECAA-------RGEDYEKVK---LLEISAEDAERWE 112
           +       ++  L  + +EEE++++  A       R E+ E+ K   LL    E+A +W 
Sbjct: 792 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWA 851

Query: 113 RKKKRKNPDLGFS----DYAAAQLRQYHRLTKQIKPDMETYERLREKHGEE 159
           R+++     L  +    +  AA+LR      K+ + +++  + L  +  ++
Sbjct: 852 REEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 902


>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
          Length = 1711

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 40/187 (21%), Positives = 83/187 (44%), Gaps = 35/187 (18%)

Query: 28  QKRE---QRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEK 84
           Q+RE   QRLR   + H +  + ++  H+++VE  +RLK  A           ELK+  +
Sbjct: 519 QEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEASERLKSQAK----------ELKDAHQ 568

Query: 85  KKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKP 144
           +++ A +       ++ E+ A+  ++  R+ + K  ++  +      +RQ  R  ++++ 
Sbjct: 569 QRKLALQEFSELNERMAELRAQ-KQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRK 627

Query: 145 DME----------TYERLREKHGEEFFPTSNSLLH-----------GTHVPSTEEIDRMV 183
           ++E          + ER   +H E F     S L            G  +   +EI ++ 
Sbjct: 628 ELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQEISKIK 687

Query: 184 IDLEKQI 190
            +LEK++
Sbjct: 688 SELEKKV 694


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 39.7 bits (91), Expect = 0.002
 Identities = 46/216 (21%), Positives = 96/216 (44%), Gaps = 41/216 (18%)

Query: 28   QKREQRLRKFRELHLMRNEA---RKLNHQEVVEEDKRL-----KLPANWEAKKARLEWEL 79
            Q+R QR  + +EL  +  E    R+   Q++ EE+  L     +  +  + +  +  W+L
Sbjct: 819  QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878

Query: 80   KEEEKKK------ECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLR 133
            +EE K++      + A + +  ++ +LL+   E+ +R ER+K+R+            Q R
Sbjct: 879  EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ----------EQER 928

Query: 134  QYHRLTKQIKPD-----METYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEK 188
            QY R  +Q++ +      E  E+ R +  E  +     L         E++      L +
Sbjct: 929  QY-REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ-----KEEQL------LGE 976

Query: 189  QIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAER 224
            + EKR +  R + Y ++ ++    E+  +  ++  R
Sbjct: 977  EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012



 Score = 39.3 bits (90), Expect = 0.003
 Identities = 44/190 (23%), Positives = 84/190 (44%), Gaps = 24/190 (12%)

Query: 15   EEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKAR 74
            E   L    +L  Q+REQ+LR+ R+    R E ++L+ Q   E D++ +     + ++  
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRD-RKFREEEQQLSRQ---ERDRKFR-EEEQQVRRQE 1443

Query: 75   LEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQ 134
             E +  EEE++       +  E+ +LL+      ER E++  R+  D  F       L +
Sbjct: 1444 RERKFLEEEQQLRQERHRKFREEEQLLQ------EREEQQLHRQERDRKF-------LEE 1490

Query: 135  YHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRD 194
              +L +Q +      + LR +  E  F      LH       ++  R  +  E+Q+ +++
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH------RQQRQRKFLQEEQQLRRQE 1544

Query: 195  KYSRRRPYND 204
            +  +RR   D
Sbjct: 1545 RGQQRRQDRD 1554



 Score = 38.5 bits (88), Expect = 0.005
 Identities = 48/229 (20%), Positives = 94/229 (41%), Gaps = 27/229 (11%)

Query: 24   ELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWE---AKKARLEWE-- 78
            +L  ++ E+R R+ RE      E  +   ++++ E++  +    WE    KK  L+ E  
Sbjct: 972  QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE 1031

Query: 79   --LKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYH 136
              L+EE +K+    R   Y + + L+   E+    E ++ R+  +L        +L+Q  
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQ-QEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090

Query: 137  RLTKQIKPD-METYERLRE-KHGEEFFPTSNSLLHGTHVP-STEEIDRMVID-------- 185
                + +P+     ER R+ +  EE       LL         +E++R   +        
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150

Query: 186  ---LEKQIEKRDKYSRRRPYNDDADI-----DYINERNAKFNKKAERFY 226
               L ++ EKR +    R Y ++ ++       + E   K  ++ ER Y
Sbjct: 1151 EQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199



 Score = 38.5 bits (88), Expect = 0.005
 Identities = 44/146 (30%), Positives = 70/146 (47%), Gaps = 21/146 (14%)

Query: 15   EEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKAR 74
            EE  L    E    +R++R RKFRE      E ++L  QE     +R  L    + ++  
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFRE------EEQQLRRQE----RERKFLQEEQQLRRQE 1720

Query: 75   LEWELKEEEK-----KKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAA 129
            LE + +EEE+     ++E   R E Y K+  LE      ER E++ +R+  D  F +   
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKI--LEEEQLRPEREEQQLRRQERDRKFRE--E 1776

Query: 130  AQLRQYHRLTKQIKPDMETYERLREK 155
             QLRQ  R  +Q++   E+  + RE+
Sbjct: 1777 EQLRQ-EREEQQLR-SQESDRKFREE 1800



 Score = 38.1 bits (87), Expect = 0.007
 Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 18/139 (12%)

Query: 28  QKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKE 87
           ++REQRL++  E   ++   R        +E++R +L    E K  RLE E +E+  K+E
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK--RLEQERREQRLKRE 570

Query: 88  CAARGEDY----EKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIK 143
              R +      E+ +   +  E  ER E++ KR+  +         +L Q  R  +++K
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE---------RLEQEERREQRLK 621

Query: 144 ---PDMETYERLREKHGEE 159
              P+ E  ++L +   +E
Sbjct: 622 REEPEEERRQQLLKSEEQE 640



 Score = 38.1 bits (87), Expect = 0.007
 Identities = 45/212 (21%), Positives = 92/212 (43%), Gaps = 23/212 (10%)

Query: 14  AEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKA 73
           AEE S      L+A+     LR+ RE  L   E ++   + + EE+++ +       ++ 
Sbjct: 773 AEEKSERGRQRLSARPP---LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK 829

Query: 74  RLEWELKEEEKKKECAAR---------GEDYEKVKLLEISAEDAERW--ERKKKRKNPDL 122
            L++  +EE+ ++   A+          ED E+ +  E   +   RW  E ++KR+   L
Sbjct: 830 ELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889

Query: 123 GFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRM 182
                   QLR+  +L ++ + +++  ER + +  E+         +       +E +++
Sbjct: 890 YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ------ERQYREEEQLQQEEEQL 943

Query: 183 VIDLEKQIEKRDKYSRRRPYNDDADIDYINER 214
              L ++ EKR +  R R Y  D  +    E+
Sbjct: 944 ---LREEREKRRRQERERQYRKDKKLQQKEEQ 972



 Score = 37.7 bits (86), Expect = 0.009
 Identities = 44/227 (19%), Positives = 97/227 (42%), Gaps = 38/227 (16%)

Query: 24  ELAAQKREQRLR-----KFRELHLMRNEARKLNHQEV-----VEEDKRLKLPANWEAKKA 73
           E   +K E++L+     + REL     + RKL  QE+      EE ++ +L    + ++ 
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309

Query: 74  RLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLR 133
           + E   +++E+++E   R E  E+ +  ++  E  ER E++ +R+              +
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRRE--------------Q 355

Query: 134 QYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKR 193
           +  R  +Q++ + E   R ++   E+       L     +   +++ R     E+Q+ + 
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR-----EQQLRRE 410

Query: 194 DKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIK-QNLER 239
            +  R +            E+  +  ++ ER   K+  E + Q L+R
Sbjct: 411 QQLRREQQLR--------REQQLRREQEEERHEQKHEQERREQRLKR 449



 Score = 37.7 bits (86), Expect = 0.009
 Identities = 41/161 (25%), Positives = 71/161 (44%), Gaps = 27/161 (16%)

Query: 8   EVLVDSAEEGSLAAAAELAAQKREQRLRKF---------RELHLMRNEARKLNHQEVVEE 58
           E L+   EE  L         KREQ  R+          R+  L R +  +L  +   EE
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606

Query: 59  DKRLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRK 118
            +RL+     E ++ RL+ E  EEE++++   + E+ E+ +  ++  E  ER E++ KR+
Sbjct: 607 VERLEQE---ERREQRLKREEPEEERRQQLL-KSEEQEERRQQQLRREQQERREQRLKRE 662

Query: 119 NPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEE 159
             +               RL +++K + E   R +E   EE
Sbjct: 663 EEE--------------ERLEQRLKREHEEERREQELAEEE 689



 Score = 37.4 bits (85), Expect = 0.012
 Identities = 45/177 (25%), Positives = 81/177 (45%), Gaps = 21/177 (11%)

Query: 29  KREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLP----ANWEAKKARLEWELKEEEK 84
           +REQ+LR+ ++L   + E R     E    ++RLK       +W   K   E E  E+E+
Sbjct: 414 RREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDW--LKREEETERHEQER 471

Query: 85  KKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLR--QYHRLTKQI 142
           +K+   R ++ E+ +   +  E+ ER E++++R+            QLR  Q  R  +++
Sbjct: 472 RKQQLKRDQEEER-RERWLKLEEEERREQQERREQ-----------QLRREQEERREQRL 519

Query: 143 KPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRR 199
           K   E  ERL+++   E             +   EE  R+  +  +Q  KR++  RR
Sbjct: 520 K-RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575



 Score = 36.6 bits (83), Expect = 0.020
 Identities = 48/218 (22%), Positives = 94/218 (43%), Gaps = 32/218 (14%)

Query: 29   KREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKEC 88
            ++EQ+L +  E  L R E  K   QE   ++++ +     + ++ +L   L+EE +K+  
Sbjct: 900  RKEQQLLQEEEEELQREEREKRRRQE---QERQYREEEQLQQEEEQL---LREEREKRRR 953

Query: 89   AARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPDM-E 147
              R   Y K K L+   E     E +K+R+            + R+   L ++ +  + E
Sbjct: 954  QERERQYRKDKKLQQKEEQLLGEEPEKRRRQE-------REKKYREEEELQQEEEQLLRE 1006

Query: 148  TYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYNDDAD 207
              E+ R +  E  +   + L         +E +++   L ++ EKR    R R Y ++ +
Sbjct: 1007 EREKRRRQEWERQYRKKDEL--------QQEEEQL---LREEREKRRLQERERQYREEEE 1055

Query: 208  IDYI------NERNAKFNKKAERFYGKYTAEIKQNLER 239
            +          ER  +  ++ ER Y K   E++Q  E+
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRK-EEELQQEEEQ 1092



 Score = 36.6 bits (83), Expect = 0.020
 Identities = 48/235 (20%), Positives = 95/235 (40%), Gaps = 22/235 (9%)

Query: 15   EEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKAR 74
            EE       E   Q RE+   +  E  L+R E  K   Q   E +++ +     + K+ +
Sbjct: 916  EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ---ERERQYRKDKKLQQKEEQ 972

Query: 75   LEWELKEEEKKKECAARGEDYEKVKLLE--ISAEDAER-----WERKKKRKNPDLGFSDY 127
            L  E  E+ +++E   +  + E+++  E  +  E+ E+     WER+ ++K+      + 
Sbjct: 973  LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032

Query: 128  AAAQLRQYHRL---TKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVI 184
               + R+  RL    +Q + + E  +   +  GEE        L   +    E       
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092

Query: 185  DLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLER 239
             L ++ EKR +  R R   ++ ++    E+  +  ++  R         +Q LER
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR---------RQELER 1138



 Score = 35.4 bits (80), Expect = 0.045
 Identities = 44/199 (22%), Positives = 79/199 (39%), Gaps = 24/199 (12%)

Query: 15   EEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKAR 74
            EE       EL  Q RE+   +  E  L+R E  K   QE+  + +  +     E +  R
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185

Query: 75   LEWELKEEEKKKECAARGEDYEKVKLLEISAEDAE-----RWERKKKRKNPD-----LGF 124
             E E + +E++++     E   + +      ED       +WE +K+    D      G 
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR 1245

Query: 125  SDYAAAQLRQYHRLTKQIKPDM-----ETYERLREKHGEEFFPTSNSLLHGTHVPSTEEI 179
             +    QL       +Q + D+     E  ER RE+    +           H P  E++
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDR------HFPEEEQL 1299

Query: 180  DRMVIDLEKQIEKRDKYSR 198
            +R   + +K+ ++RD+ S+
Sbjct: 1300 ER---EEQKEAKRRDRKSQ 1315



 Score = 35.4 bits (80), Expect = 0.045
 Identities = 42/178 (23%), Positives = 79/178 (44%), Gaps = 22/178 (12%)

Query: 24   ELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEE 83
            E   Q+R+ R RKFRE   +R E R+       E D++ +L    E +K R     ++E+
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQE-REEQQLSRQERDRKFRL----EEQKVR-----RQEQ 1593

Query: 84   KKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIK 143
            ++K      ED ++++  E   +   R ER +K +  +    +    QL +  R  K ++
Sbjct: 1594 ERKFM----EDEQQLRRQE--GQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647

Query: 144  PD-----METYERLREKHGEEFFPTSNSLLHGTHVP-STEEIDRMVIDLEKQIEKRDK 195
             +      E  ++LR     +F      L  G       +E DR   + E+Q+ ++++
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQER 1705



 Score = 35.0 bits (79), Expect = 0.059
 Identities = 40/175 (22%), Positives = 84/175 (48%), Gaps = 23/175 (13%)

Query: 28  QKREQRLRKFRELHLMRNEAR--KLNHQEVVEEDKRLKLPANWEAKKARLEWEL-KEEEK 84
           ++REQ+ R+ ++L   + E R  +L  QE   E++RL+       ++ R E +L +E+E+
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQE---EEERLQ-------QRLRSEQQLRREQEE 544

Query: 85  KKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKP 144
           ++E   + E+ +++        + ER E++ KR+  +         + R+  RL ++ + 
Sbjct: 545 RREQLLKREEEKRL--------EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596

Query: 145 DMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRR 199
            +E  +RL+ +  E                  EE  + ++  E+Q E+R +  RR
Sbjct: 597 RLE--QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR 649



 Score = 33.1 bits (74), Expect = 0.22
 Identities = 43/185 (23%), Positives = 80/185 (43%), Gaps = 27/185 (14%)

Query: 28  QKREQRLRKF-----RELHLMRNEARKLNHQEVV--EEDKRLKLPANWEAKKARLEWELK 80
           ++REQRL++      R   L+++E ++   Q+ +  E+ +R +     E ++ RLE  LK
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK 673

Query: 81  EEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGF---SDYAAAQLRQYHR 137
            E +           E+ +  E++ E+ E+   + K + P   +   S+  A Q + Y R
Sbjct: 674 REHE-----------EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722

Query: 138 LTKQ--IKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDK 195
             KQ   +   E  E+ R +  E  +          H    EE  R     + Q E++ +
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEER----AHRQQQEEEQRRDFTWQWQAEEKSE 778

Query: 196 YSRRR 200
             R+R
Sbjct: 779 RGRQR 783



 Score = 31.6 bits (70), Expect = 0.65
 Identities = 44/215 (20%), Positives = 92/215 (42%), Gaps = 35/215 (16%)

Query: 28   QKREQRLRKFRELH-----LMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWE--LK 80
            Q+RE++ R+  EL      L+R E  K   QE+  + +        E ++ + E E  L+
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYR--------EEEEVQQEEEQLLR 1155

Query: 81   EEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLR------- 133
            EE +K+        Y + + L+   E   R E++K+R+  +  + +    Q +       
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215

Query: 134  ---QYHRLTKQIKPDMETYER-----LREKHGEEFFPTSNSLLHGTHVPSTEEIDRMV-- 183
               Q   L  Q +P+ E   R      + +  E+F    +S L      S +++  ++  
Sbjct: 1216 DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ--SQQDLQHLLGE 1273

Query: 184  -IDLEKQIEKRDKYSRRRPYNDDADIDYINERNAK 217
              + +++ E+R    R R + ++  ++   ++ AK
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLEREEQKEAK 1308



 Score = 29.3 bits (64), Expect = 3.2
 Identities = 43/212 (20%), Positives = 86/212 (40%), Gaps = 16/212 (7%)

Query: 28  QKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKE 87
           ++REQ+LR+ +E      + R+   +E  E+  R +     E +  R +   +E++ ++E
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404

Query: 88  CAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPDME 147
              R E        ++  E   R E++ +R+       +    Q  +  R  +++K + E
Sbjct: 405 QQLRREQ-------QLRREQQLRREQQLRREQ-----EEERHEQKHEQERREQRLKREQE 452

Query: 148 TYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYNDDAD 207
             ER      EE             +   +E +R    L+ + E+R +   RR      +
Sbjct: 453 --ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510

Query: 208 IDYINERNAKFNKKAERFYGKYTAEIKQNLER 239
            +   E+  K  ++ ER   +  +E  Q L R
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSE--QQLRR 540


>gi|13569843 nucleolar protein 7, 27kDa [Homo sapiens]
          Length = 257

 Score = 39.7 bits (91), Expect = 0.002
 Identities = 35/131 (26%), Positives = 60/131 (45%), Gaps = 11/131 (8%)

Query: 12  DSAEEGSLAAAAELAAQKREQRLRK-FRELHLMRNEARKLNHQEVVEEDKRLKLP----- 65
           D A E    A+A+  A++ E+R+R+  R    +  E RK   +  +E+ KR  LP     
Sbjct: 61  DEAPEELTFASAQAEAREEERRVRETVRRDKTLLKEKRKRREELFIEQKKRKLLPDTILE 120

Query: 66  -----ANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNP 120
                +    KK+  + +    +KK E   +G D +KVK+ ++ +    +     + K+ 
Sbjct: 121 KLTTASQTNIKKSPGKVKEVNLQKKNEDCEKGNDSKKVKVQKVQSVSQNKSYLAVRLKDQ 180

Query: 121 DLGFSDYAAAQ 131
           DL  S   AAQ
Sbjct: 181 DLRDSRQQAAQ 191


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 39.3 bits (90), Expect = 0.003
 Identities = 32/135 (23%), Positives = 66/135 (48%), Gaps = 19/135 (14%)

Query: 28  QKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKE 87
           Q+RE+++++  E   +R +  K+  QE +  +K  K+      ++  + WE  +EEK +E
Sbjct: 298 QEREEKIQEQEEK--IREQEEKMRRQEEMMWEKEEKM-----RRQEEMMWE--KEEKIRE 348

Query: 88  CAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQ---IKP 144
              +  + EK++  E   ++ E+   ++KR+  +       A   RQ  ++ +Q   I+ 
Sbjct: 349 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE-------AKMWRQEEKIREQEEKIRE 401

Query: 145 DMETYERLREKHGEE 159
             E  +   EK GE+
Sbjct: 402 QEEMMQEQEEKMGEQ 416



 Score = 35.0 bits (79), Expect = 0.059
 Identities = 42/200 (21%), Positives = 85/200 (42%), Gaps = 31/200 (15%)

Query: 24  ELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEE 83
           EL  +  EQ   K RE    R E  K+  QE  +E          EAK  R E +++E+E
Sbjct: 348 ELEEKMHEQE--KIREQEEKRQEEEKIREQEKRQEQ---------EAKMWRQEEKIREQE 396

Query: 84  KKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIK 143
           +K       E+  + +  ++  ++ + WE++++ +  +           RQ  ++ +Q K
Sbjct: 397 EK---IREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQE-------EKMRRQEEKIREQEK 446

Query: 144 PDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYN 203
              E  E++RE+  EE        +         E +  + + E +++++++  RR+   
Sbjct: 447 KIREQEEKIREQ--EEMMQEQEEKM--------GEQEGKMCEQEAKMQEQEEKMRRQEEK 496

Query: 204 DDADIDYINERNAKFNKKAE 223
                  I E+  K  ++ E
Sbjct: 497 IREQEKKIREQEEKIREQEE 516


>gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo
           sapiens]
          Length = 373

 Score = 39.3 bits (90), Expect = 0.003
 Identities = 34/113 (30%), Positives = 54/113 (47%), Gaps = 8/113 (7%)

Query: 28  QKREQRLRKFRELHL---MRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEK 84
           QK+ ++ RK RE  +   M  +A K   +E ++E  + K    W  KK   E E K++EK
Sbjct: 197 QKKNEQKRKEREQKINKEMEEKAAKELEKEYLQEKAKEKYQ-EWLKKKNAEECERKKKEK 255

Query: 85  KKECAARGEDYEKVKLLEISAEDAERW-ERKKKRKNPDLGFSDYAAAQLRQYH 136
           +KE   + E  EK    EI+ +  + W E  K +  P      YA  +L  ++
Sbjct: 256 EKEKQQQAEIQEK---KEIAEKKFQEWLENAKHKPRPAAKSYGYANGKLTGFY 305



 Score = 32.7 bits (73), Expect = 0.29
 Identities = 39/151 (25%), Positives = 68/151 (45%), Gaps = 21/151 (13%)

Query: 27  AQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPAN----WEA------KKARLE 76
           A   E ++   R + L    + ++  +   EE K+++LP +    WE       K+ R  
Sbjct: 100 AHDSEAKVASLRGMELQGCASTQVESENNQEEQKQVRLPESRLTPWEVWFIGKEKEERDR 159

Query: 77  WELKE-EEKKKECAARGEDYEKVKLLEISAEDAERWERKK---KRKNPDLGFS----DYA 128
            +LK  EE  ++   R E  E+ K   I+ E  + W +KK   KRK  +   +    + A
Sbjct: 160 LQLKALEELNQQLEKRKEMEEREKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEMEEKA 219

Query: 129 AAQLRQYHRLTKQIKPDMETYERLREKHGEE 159
           A +L + +    Q K   +  E L++K+ EE
Sbjct: 220 AKELEKEY---LQEKAKEKYQEWLKKKNAEE 247


>gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]
          Length = 247

 Score = 39.3 bits (90), Expect = 0.003
 Identities = 48/213 (22%), Positives = 88/213 (41%), Gaps = 20/213 (9%)

Query: 29  KREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKE------- 81
           KR+ R+     + + R+     +    +++      P  WE  K +LE + K        
Sbjct: 3   KRDNRVAYMNPIAMARSRGPIQSSGPTIQDYLNRPRPT-WEEVKEQLEKKKKGSKALAEF 61

Query: 82  EEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQ 141
           EEK  E   +  +  + KLL  S   +++ +RKKK K     +S  +++        +  
Sbjct: 62  EEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDS 121

Query: 142 IKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMV-----IDLEKQI----EK 192
              D +  +R R+K       +S S +  T   S + + +        + EK I    +K
Sbjct: 122 EDEDKKQGKR-RKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKK 180

Query: 193 RDKYSRRRPYNDD--ADIDYINERNAKFNKKAE 223
           R  YS  +P + +  ++ +YI E  AK  K +E
Sbjct: 181 RKMYSEDKPLSSESLSESEYIEEVRAKKKKSSE 213


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 38.9 bits (89), Expect = 0.004
 Identities = 45/214 (21%), Positives = 92/214 (42%), Gaps = 20/214 (9%)

Query: 30  REQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKL----PANWEAKKA--RLEWELKEEE 83
           REQ  +  R+  +M  +  K+  QE +  +K  K+       WE ++    LE ++ E+E
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQE 390

Query: 84  KKKECAARGEDYEKVKLLEISAE-DAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQI 142
           K +E   + ++ EK++  E   E +A+ W +++K +  +    +      RQ  ++ +Q 
Sbjct: 391 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE 450

Query: 143 K-------PDMETYERLREK--HGEEFFPTSNSLLHGTHVPSTEE----IDRMVIDLEKQ 189
           K        + E   R  EK    EE +     +     +   EE     +  + D E++
Sbjct: 451 KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEK 510

Query: 190 IEKRDKYSRRRPYNDDADIDYINERNAKFNKKAE 223
           I ++++   R+        + I E+  K  ++ E
Sbjct: 511 IREQEEKMWRQEEKIREQEEKIREQEEKIREQEE 544



 Score = 37.4 bits (85), Expect = 0.012
 Identities = 44/201 (21%), Positives = 84/201 (41%), Gaps = 15/201 (7%)

Query: 30  REQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKECA 89
           REQ  R+ +E  + R E +    +E + E          E K  R E ++ E+EK +E  
Sbjct: 406 REQEKRQEQEAKMWRQEEKIREQEEKIREQ---------EKKMWRQEEKIHEQEKIREEE 456

Query: 90  ARGEDYEKVKLLEISAEDAERWERKKKRKNPD--LGFSDYAAAQLRQYHRLTKQIKPDME 147
            R E  E  +  E   E  E W +K+K    +      +    Q  + H   ++I+   E
Sbjct: 457 KRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEE 516

Query: 148 TYERLREK--HGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYNDD 205
              R  EK    EE        +        E+ ++M  + E+++++++K  R+     +
Sbjct: 517 KMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMG-EQEEKMQEQEKMRRQEEKIRE 575

Query: 206 ADIDYINERNAKFNKKAERFY 226
            + + I E+  K  ++ E+ +
Sbjct: 576 QE-EKIREQKEKIREQEEKIW 595



 Score = 35.8 bits (81), Expect = 0.035
 Identities = 48/209 (22%), Positives = 87/209 (41%), Gaps = 38/209 (18%)

Query: 24  ELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEE 83
           EL  +  EQ   K RE    R E  K+  QE  +E          EAK  R E +++E+E
Sbjct: 381 ELEEKMHEQE--KIREQEEKRQEEEKIREQEKRQEQ---------EAKMWRQEEKIREQE 429

Query: 84  KK-----KECAARGE---DYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQY 135
           +K     K+   + E   + EK++  E   E  E W +++K               +R+ 
Sbjct: 430 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK---------------IREQ 474

Query: 136 HRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDK 195
             + +Q K  M   E++R++  EE        +H       E+ ++M    EK  E+ +K
Sbjct: 475 EEIWRQ-KEKMHEQEKIRKQ--EEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEK 531

Query: 196 YSRRRPYNDDADIDYINERNAKFNKKAER 224
              +     + + + + E+  K  ++ E+
Sbjct: 532 IREQEEKIREQE-EMMQEQEEKMGEQEEK 559



 Score = 32.3 bits (72), Expect = 0.38
 Identities = 22/127 (17%), Positives = 62/127 (48%), Gaps = 7/127 (5%)

Query: 29  KREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKEC 88
           ++E+++R+  E   +R +  K+  QE + +++  K+    E  + + +   +EE+ +++ 
Sbjct: 520 RQEEKIREQEEK--IREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE 577

Query: 89  AARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMET 148
               E  EK++      ++ + WE+++K +  +    +       Q  ++ +Q +   E 
Sbjct: 578 EKIREQKEKIR-----EQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 632

Query: 149 YERLREK 155
            E++R +
Sbjct: 633 EEKMRRQ 639



 Score = 28.1 bits (61), Expect = 7.2
 Identities = 28/140 (20%), Positives = 63/140 (45%), Gaps = 24/140 (17%)

Query: 20  AAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWEL 79
           + +A+L AQ  E  L  +  L+  + E +    +E ++E         WE K    E ++
Sbjct: 276 SVSAKLQAQVEENEL--WNRLN-QQQEEKMWRQEEKIQE---------WEEKIQEQEEKI 323

Query: 80  KEEEKK----KECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQY 135
           +E+E+K    +E   R E+    K  ++  ++   WE+++K +  +          + + 
Sbjct: 324 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLE--------EMMWEK 375

Query: 136 HRLTKQIKPDMETYERLREK 155
               ++++  M   E++RE+
Sbjct: 376 EEKIRELEEKMHEQEKIREQ 395


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 38.9 bits (89), Expect = 0.004
 Identities = 45/206 (21%), Positives = 96/206 (46%), Gaps = 30/206 (14%)

Query: 28  QKREQRLRKFRELHLMRNEARKLNHQEVV----EEDKRLKLPANWEAK-KARLEWEL--K 80
           Q++E+++R+  E   +R +  K+  QE +    EE  R +    WE + K R + E+  +
Sbjct: 378 QEQEEKIREQEEK--IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 435

Query: 81  EEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTK 140
           +EEK +E   +  + EK++  E   ++ E+   ++KR+  +       A   RQ  ++ +
Sbjct: 436 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE-------AKMWRQEEKIRE 488

Query: 141 QIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRR 200
           Q +   E  E++  +  EE       +         EE+ R     E++I ++++  R++
Sbjct: 489 QEEKIREQEEKMWRQ--EEKIHEQEKIREEEKRQEQEEMWRQ----EEKIREQEEIWRQK 542

Query: 201 PYNDDADIDYINERNAKFNKKAERFY 226
                   + I+E+  K  K+ E+ +
Sbjct: 543 --------EKIHEQEEKIRKQEEKMW 560



 Score = 38.9 bits (89), Expect = 0.004
 Identities = 46/200 (23%), Positives = 77/200 (38%), Gaps = 15/200 (7%)

Query: 30  REQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKECA 89
           REQ  R+ +E  + R E +    +E + E          E K  R E ++ E+EK +E  
Sbjct: 467 REQEKRQEQEAKMWRQEEKIREQEEKIREQ---------EEKMWRQEEKIHEQEKIREEE 517

Query: 90  ARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQ---YHRLTKQIKPDM 146
            R E  E  +  E   E  E W +K+K    +           RQ    H   ++I+   
Sbjct: 518 KRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQE 577

Query: 147 ETYERLREK--HGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYND 204
           E   R  EK    EE        +      + E+ ++M    EK  E+ +K   +     
Sbjct: 578 EKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMR 637

Query: 205 DADIDYINERNAKFNKKAER 224
             + + I E+  K  ++ E+
Sbjct: 638 RQE-EKIREQEKKIREQEEK 656



 Score = 35.4 bits (80), Expect = 0.045
 Identities = 46/210 (21%), Positives = 86/210 (40%), Gaps = 25/210 (11%)

Query: 24  ELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEE 83
           EL  +  EQ   K RE    R E  K+  QE  +E          EAK  R E +++E+E
Sbjct: 442 ELEEKMHEQE--KIREQEEKRQEEEKIREQEKRQEQ---------EAKMWRQEEKIREQE 490

Query: 84  KK----KECAARGE----DYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQY 135
           +K    +E   R E    + EK++  E   E  E W +++K +       +    Q  + 
Sbjct: 491 EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE-----QEEIWRQKEKI 545

Query: 136 HRLTKQIKPDMETYERLREK-HGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRD 194
           H   ++I+   E   R  EK H +E                  E +  + + E++I +++
Sbjct: 546 HEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQE 605

Query: 195 KYSRRRPYNDDADIDYINERNAKFNKKAER 224
           + ++ +        + + E+  K  ++ E+
Sbjct: 606 EMTQEQEEKMGEQEEKMCEQEEKMQEQEEK 635



 Score = 29.6 bits (65), Expect = 2.5
 Identities = 42/212 (19%), Positives = 84/212 (39%), Gaps = 18/212 (8%)

Query: 4   IAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVV------- 56
           I   E  +   EE       ++  Q++ +   K +E   M  +  K+  QE +       
Sbjct: 486 IREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKI 545

Query: 57  ---EEDKRLKLPANW--EAKKARLEWELKEEEKK--KECAARGEDYEKVKLLEISAEDAE 109
              EE  R +    W  E K    E +++E+E+K  ++     E  EK++  E    + E
Sbjct: 546 HEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQE 605

Query: 110 RW--ERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSL 167
               E+++K    +    +       Q  ++ +Q +   E  +++RE+  EE       +
Sbjct: 606 EMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ--EEKIREQEEM 663

Query: 168 LHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRR 199
           +        E+ ++M    EK  E+ +K  R+
Sbjct: 664 MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 695



 Score = 28.9 bits (63), Expect = 4.2
 Identities = 28/140 (20%), Positives = 63/140 (45%), Gaps = 24/140 (17%)

Query: 20  AAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWEL 79
           + +A+L AQ  E  L  +  L+  + E +    +E ++E         WE K    E ++
Sbjct: 337 SVSAKLQAQVEENEL--WNRLN-QQQEEKMWRQEEKIQE---------WEEKIQEQEEKI 384

Query: 80  KEEEKK----KECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQY 135
           +E+E+K    +E   R E+    K  ++  ++   WE+++K +  +          + + 
Sbjct: 385 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE--------EMMWEK 436

Query: 136 HRLTKQIKPDMETYERLREK 155
               ++++  M   E++RE+
Sbjct: 437 EEKIRELEEKMHEQEKIREQ 456


>gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]
          Length = 237

 Score = 38.5 bits (88), Expect = 0.005
 Identities = 47/186 (25%), Positives = 78/186 (41%), Gaps = 18/186 (9%)

Query: 50  LNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEK-KKECAARGEDYEKVKLLEISAEDA 108
           LN      E+ + +L    +  KA  E+E K  E  KKE     E     KLL  S   +
Sbjct: 24  LNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHRE-----KLLSGSESSS 78

Query: 109 ERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLL 168
           ++ +RKKK K     +S  +++        +     D +  +R R+K       +S S +
Sbjct: 79  KKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKR-RKKKKNRSHKSSESSM 137

Query: 169 HGTHVPSTEEIDRMV-----IDLEKQI----EKRDKYSRRRPYNDD--ADIDYINERNAK 217
             T   S + + +        + EK I    +KR  YS  +P + +  ++ +YI E  AK
Sbjct: 138 SETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAK 197

Query: 218 FNKKAE 223
             K +E
Sbjct: 198 KKKSSE 203


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 38.5 bits (88), Expect = 0.005
 Identities = 42/164 (25%), Positives = 75/164 (45%), Gaps = 23/164 (14%)

Query: 61   RLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNP 120
            RL+ P+N  A ++  +    +  +K+   +   D EK K LEI+ E   R ++ K+ +  
Sbjct: 1205 RLRSPSNDSAHRSGDD----QSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPS 1260

Query: 121  DLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEID 180
                SD      RQ  R     +   E+  ++  + G   F + + L         +E D
Sbjct: 1261 RSTSSD------RQDSRSHSSRRSSPESDRQVHSRSGS--FDSRDRL---------QERD 1303

Query: 181  RMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAER 224
            R   D E++ E+RD  +R+R ++ DAD D+   R+    ++ ER
Sbjct: 1304 RYEHDRERERERRD--TRQREWDRDADKDWPRNRDRDRLRERER 1345



 Score = 32.0 bits (71), Expect = 0.50
 Identities = 32/124 (25%), Positives = 54/124 (43%), Gaps = 4/124 (3%)

Query: 28  QKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAK-KARLEWELKEEEKKK 86
           ++RE+R R+ RE    R   R+   +   E DK  +   +WE K K R +   K EE ++
Sbjct: 751 REREERERE-RERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIRE 809

Query: 87  ECAAR-GEDYEK-VKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKP 144
           +   R G D  K  K        + R   K++R++     +  +     + HRL  Q+  
Sbjct: 810 DRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVR 869

Query: 145 DMET 148
             E+
Sbjct: 870 PQES 873



 Score = 29.6 bits (65), Expect = 2.5
 Identities = 34/151 (22%), Positives = 64/151 (42%), Gaps = 22/151 (14%)

Query: 27  AQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWEL---KEEE 83
           A++RE+   K R+    R+       +   E D+  +     E ++   E E    +E E
Sbjct: 712 AREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERE 771

Query: 84  KKKECAARGEDYEKVKLLEISAEDAERWERKKKR------KNPDLG---------FSDYA 128
           +++E  AR  D E+ +  +   +D  R +R++KR      +NP  G         + +  
Sbjct: 772 RERE-RARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEG 830

Query: 129 AAQLRQYHRLTKQIKPDMETY---ERLREKH 156
           +   RQ  +  ++  PD + Y   +   EKH
Sbjct: 831 SPSPRQSPKRRREHSPDSDAYNSGDDKNEKH 861



 Score = 29.3 bits (64), Expect = 3.2
 Identities = 21/100 (21%), Positives = 45/100 (45%), Gaps = 1/100 (1%)

Query: 28  QKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKE 87
           ++RE+   + +E  L R  AR+   +   E D+      + + ++ R     +E+E+++E
Sbjct: 693 RERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERE 752

Query: 88  CAARGEDYEKVKLLEISAE-DAERWERKKKRKNPDLGFSD 126
              R  + E+ +  E   E + ER   + K +     + D
Sbjct: 753 REERERERERERERERERERERERARERDKERERQRDWED 792


>gi|92859701 myosin VI [Homo sapiens]
          Length = 1285

 Score = 38.1 bits (87), Expect = 0.007
 Identities = 62/253 (24%), Positives = 106/253 (41%), Gaps = 49/253 (19%)

Query: 8    EVLVDSAEEGSLAAAAELAAQKREQRLRKFRE----LHLMRNEARKLNHQEVVEEDKRLK 63
            + LV S+EE   A   +   ++  +RLR+ +E        R E  K   +E  EE++R+K
Sbjct: 900  DALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKE--EEERRMK 957

Query: 64   LPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWER--------KK 115
            L    EAK+ +     +EEE+KK      ED EK    E+ A+ A + E         ++
Sbjct: 958  L--EMEAKRKQ-----EEEERKKR-----EDDEKRIQAEVEAQLARQKEEESQQQAVLEQ 1005

Query: 116  KRKNPDLG----------FSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSN 165
            +R++ +L            SD A A L    R     +P M   +  +E    EF     
Sbjct: 1006 ERRDRELALRIAQSEAELISDEAQADLAL--RRNDGTRPKMTPEQMAKEM--SEFLSRGP 1061

Query: 166  SLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERF 225
            ++L       T++ D   +   K  E RD        N   DI+ +     +F+++ + +
Sbjct: 1062 AVLATKAAAGTKKYD---LSKWKYAELRD------TINTSCDIELLAACREEFHRRLKVY 1112

Query: 226  YGKYTAEIKQNLE 238
            +   +   K+N E
Sbjct: 1113 HAWKSKNKKRNTE 1125


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 37.7 bits (86), Expect = 0.009
 Identities = 48/219 (21%), Positives = 88/219 (40%), Gaps = 27/219 (12%)

Query: 30  REQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKECA 89
           REQ  R+ +E  + R E +    +E + E          E K  R E ++ E+EK +E  
Sbjct: 420 REQEKRQEQEAKMWRQEEKIREQEEKIREQ---------EKKMWRQEEKIHEQEKIREEE 470

Query: 90  ARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETY 149
            R E  E  +  E   E  E W +K+K    +           RQ  ++ +Q +   E  
Sbjct: 471 KRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQE 530

Query: 150 ERL-----REKHGEEFFPTSNSLLHGTHV----PSTEEIDRMVIDLEKQIEKRDKYSRRR 200
           E++     + +  EE +     +     +       E+ D+M    EK  E+ +K  R+ 
Sbjct: 531 EKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQE 590

Query: 201 PYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLER 239
                   + I E+  K  ++ E+ + K   +I++  E+
Sbjct: 591 --------EKIREQEEKRQEQEEKMW-KQEEKIREQEEK 620



 Score = 36.6 bits (83), Expect = 0.020
 Identities = 44/208 (21%), Positives = 86/208 (41%), Gaps = 15/208 (7%)

Query: 30  REQRLRKFRELHLMRNEARKLNHQEVV----EEDKRLKLPANWEAK-KARLEWEL--KEE 82
           REQ  +  R+  +M  +  K+  QE +    EE  R +    WE + K R + E+  ++E
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 390

Query: 83  EKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQI 142
           EK +E   +  + EK++  E   ++ E+   ++KR+  +            Q  ++ +Q 
Sbjct: 391 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 450

Query: 143 KPDMETYERLRE----KHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSR 198
           K      E++ E    +  E+             +   EEI R    + +Q EK  K   
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510

Query: 199 RRPYNDDADIDYINERNAKFNKKAERFY 226
           +    ++     I E+  K  ++ E+ +
Sbjct: 511 KVWRQEEK----IREQEEKIREQEEKMW 534



 Score = 33.5 bits (75), Expect = 0.17
 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 24/144 (16%)

Query: 24  ELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEE 83
           EL  +  EQ   K RE    R E  K+  QE  +E          EAK  R E +++E+E
Sbjct: 395 ELEEKMHEQE--KIREQEEKRQEEEKIREQEKRQEQ---------EAKMWRQEEKIREQE 443

Query: 84  KK-----KECAARGE---DYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQY 135
           +K     K+   + E   + EK++  E   E  E W +++K     +   +    Q  + 
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK-----IHEQEEIWRQKEKM 498

Query: 136 HRLTKQIKPDMETYERLREKHGEE 159
           H   ++I+   E   R  EK  E+
Sbjct: 499 HEQEEKIRKQEEKVWRQEEKIREQ 522



 Score = 29.3 bits (64), Expect = 3.2
 Identities = 29/140 (20%), Positives = 63/140 (45%), Gaps = 16/140 (11%)

Query: 20  AAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWEL 79
           + +A+L AQ  E  L  +  L+  + E +    +E ++E         WE K    E ++
Sbjct: 276 SVSAKLQAQVEENEL--WNRLN-QQQEEKMWRQEEKIQE---------WEEKIQEQEEKI 323

Query: 80  KEEEKK----KECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQY 135
           +E+E+K    +E   R E+    K  ++  ++   WE+++K +  +    +      RQ 
Sbjct: 324 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 383

Query: 136 HRLTKQIKPDMETYERLREK 155
             + ++ +   E  E++ E+
Sbjct: 384 EMMWEKEEKIRELEEKMHEQ 403


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 37.7 bits (86), Expect = 0.009
 Identities = 51/203 (25%), Positives = 87/203 (42%), Gaps = 30/203 (14%)

Query: 2    AAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKR 61
            A   A+E L  +  E    + A   A+ +  RL K     L   EA+  + QE+++E+ R
Sbjct: 1299 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK----ELSSTEAQLHDAQELLQEETR 1354

Query: 62   LKLPAN-----WEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKK 116
             KL         EA+ A L  +L+EE   +E A R         L+ +      W R+++
Sbjct: 1355 AKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE--------LQTAQAQLSEWRRRQE 1406

Query: 117  RKNPDLGFSDYAAAQ-LRQYHRLTKQIKPDMETYERL---REKHGEEFFPTSNSLLHGTH 172
             +   L   + A  +  R+   LT+++    ET +RL   R +  +E    +  L     
Sbjct: 1407 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL----- 1461

Query: 173  VPSTEEIDRMVIDLEKQIEKRDK 195
                E+  ++V  LEK+  K D+
Sbjct: 1462 ----EQQRQLVSTLEKKQRKFDQ 1480



 Score = 35.0 bits (79), Expect = 0.059
 Identities = 40/220 (18%), Positives = 95/220 (43%), Gaps = 23/220 (10%)

Query: 16   EGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARL 75
            E  L    E   ++R Q  ++ R+  + R+E RK     V              A + +L
Sbjct: 1602 ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV--------------AARKKL 1647

Query: 76   EWELKEEEKKKECAARGEDYEKVKLLEISAEDAERW-ERKKKRKNPDLGFSDYAAAQ--L 132
            E EL+E + +   A +G++    +L ++ A+  E W E ++ R + +  FS    ++  L
Sbjct: 1648 EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1707

Query: 133  RQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEK 192
            +       +++ ++   +R R +  ++    ++ + +G    +       +++ ++Q+E 
Sbjct: 1708 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA------ILEEKRQLEG 1761

Query: 193  RDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAE 232
            R          + ++ + +N+R  K   + E    + +AE
Sbjct: 1762 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE 1801



 Score = 29.6 bits (65), Expect = 2.5
 Identities = 34/120 (28%), Positives = 56/120 (46%), Gaps = 22/120 (18%)

Query: 14   AEEGSLAAAAELAAQKREQRLRKFRE-LHLMRNEARKLNHQ-------------EVVEED 59
            AEEG+     +L     E +++KF E L L+ ++  KL+ +             +  EE+
Sbjct: 986  AEEGA-RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE 1044

Query: 60   KRLK----LPANWEAKKARLEWELKEEEKKK---ECAARGEDYEKVKLLEISAEDAERWE 112
            +++K    L   +EA  A +E  L++EEK +   E   R  D E  +L E   E  +R E
Sbjct: 1045 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAE 1104


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 37.7 bits (86), Expect = 0.009
 Identities = 51/203 (25%), Positives = 87/203 (42%), Gaps = 30/203 (14%)

Query: 2    AAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKR 61
            A   A+E L  +  E    + A   A+ +  RL K     L   EA+  + QE+++E+ R
Sbjct: 1291 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK----ELSSTEAQLHDAQELLQEETR 1346

Query: 62   LKLPAN-----WEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKK 116
             KL         EA+ A L  +L+EE   +E A R         L+ +      W R+++
Sbjct: 1347 AKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE--------LQTAQAQLSEWRRRQE 1398

Query: 117  RKNPDLGFSDYAAAQ-LRQYHRLTKQIKPDMETYERL---REKHGEEFFPTSNSLLHGTH 172
             +   L   + A  +  R+   LT+++    ET +RL   R +  +E    +  L     
Sbjct: 1399 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL----- 1453

Query: 173  VPSTEEIDRMVIDLEKQIEKRDK 195
                E+  ++V  LEK+  K D+
Sbjct: 1454 ----EQQRQLVSTLEKKQRKFDQ 1472



 Score = 35.0 bits (79), Expect = 0.059
 Identities = 40/220 (18%), Positives = 95/220 (43%), Gaps = 23/220 (10%)

Query: 16   EGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARL 75
            E  L    E   ++R Q  ++ R+  + R+E RK     V              A + +L
Sbjct: 1594 ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV--------------AARKKL 1639

Query: 76   EWELKEEEKKKECAARGEDYEKVKLLEISAEDAERW-ERKKKRKNPDLGFSDYAAAQ--L 132
            E EL+E + +   A +G++    +L ++ A+  E W E ++ R + +  FS    ++  L
Sbjct: 1640 EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1699

Query: 133  RQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEK 192
            +       +++ ++   +R R +  ++    ++ + +G    +       +++ ++Q+E 
Sbjct: 1700 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA------ILEEKRQLEG 1753

Query: 193  RDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAE 232
            R          + ++ + +N+R  K   + E    + +AE
Sbjct: 1754 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE 1793



 Score = 29.6 bits (65), Expect = 2.5
 Identities = 34/120 (28%), Positives = 56/120 (46%), Gaps = 22/120 (18%)

Query: 14   AEEGSLAAAAELAAQKREQRLRKFRE-LHLMRNEARKLNHQ-------------EVVEED 59
            AEEG+     +L     E +++KF E L L+ ++  KL+ +             +  EE+
Sbjct: 978  AEEGA-RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE 1036

Query: 60   KRLK----LPANWEAKKARLEWELKEEEKKK---ECAARGEDYEKVKLLEISAEDAERWE 112
            +++K    L   +EA  A +E  L++EEK +   E   R  D E  +L E   E  +R E
Sbjct: 1037 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAE 1096


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 37.7 bits (86), Expect = 0.009
 Identities = 51/203 (25%), Positives = 87/203 (42%), Gaps = 30/203 (14%)

Query: 2    AAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKR 61
            A   A+E L  +  E    + A   A+ +  RL K     L   EA+  + QE+++E+ R
Sbjct: 1332 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK----ELSSTEAQLHDAQELLQEETR 1387

Query: 62   LKLPAN-----WEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKK 116
             KL         EA+ A L  +L+EE   +E A R         L+ +      W R+++
Sbjct: 1388 AKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE--------LQTAQAQLSEWRRRQE 1439

Query: 117  RKNPDLGFSDYAAAQ-LRQYHRLTKQIKPDMETYERL---REKHGEEFFPTSNSLLHGTH 172
             +   L   + A  +  R+   LT+++    ET +RL   R +  +E    +  L     
Sbjct: 1440 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL----- 1494

Query: 173  VPSTEEIDRMVIDLEKQIEKRDK 195
                E+  ++V  LEK+  K D+
Sbjct: 1495 ----EQQRQLVSTLEKKQRKFDQ 1513



 Score = 35.0 bits (79), Expect = 0.059
 Identities = 40/220 (18%), Positives = 95/220 (43%), Gaps = 23/220 (10%)

Query: 16   EGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARL 75
            E  L    E   ++R Q  ++ R+  + R+E RK     V              A + +L
Sbjct: 1635 ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV--------------AARKKL 1680

Query: 76   EWELKEEEKKKECAARGEDYEKVKLLEISAEDAERW-ERKKKRKNPDLGFSDYAAAQ--L 132
            E EL+E + +   A +G++    +L ++ A+  E W E ++ R + +  FS    ++  L
Sbjct: 1681 EGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1740

Query: 133  RQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEK 192
            +       +++ ++   +R R +  ++    ++ + +G    +       +++ ++Q+E 
Sbjct: 1741 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA------ILEEKRQLEG 1794

Query: 193  RDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAE 232
            R          + ++ + +N+R  K   + E    + +AE
Sbjct: 1795 RLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE 1834



 Score = 29.6 bits (65), Expect = 2.5
 Identities = 34/120 (28%), Positives = 56/120 (46%), Gaps = 22/120 (18%)

Query: 14   AEEGSLAAAAELAAQKREQRLRKFRE-LHLMRNEARKLNHQ-------------EVVEED 59
            AEEG+     +L     E +++KF E L L+ ++  KL+ +             +  EE+
Sbjct: 1019 AEEGA-RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE 1077

Query: 60   KRLK----LPANWEAKKARLEWELKEEEKKK---ECAARGEDYEKVKLLEISAEDAERWE 112
            +++K    L   +EA  A +E  L++EEK +   E   R  D E  +L E   E  +R E
Sbjct: 1078 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAE 1137


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 37.7 bits (86), Expect = 0.009
 Identities = 24/85 (28%), Positives = 45/85 (52%), Gaps = 4/85 (4%)

Query: 36  KFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKK--KECAARGE 93
           K +E   M+ +  K+  QE +E+  + +    W+ +K R E  ++E EKK  +E     E
Sbjct: 672 KMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE 731

Query: 94  DYEKVKLLE--ISAEDAERWERKKK 116
             EK++  E  +  ++ E WE+++K
Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEK 756



 Score = 35.0 bits (79), Expect = 0.059
 Identities = 39/181 (21%), Positives = 83/181 (45%), Gaps = 19/181 (10%)

Query: 28  QKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKL-----------PANWEAKKARLE 76
           ++RE+++R+  E+  MR +  K+  QE   +++  K+              WE ++   E
Sbjct: 592 REREKKMREEEEM--MREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649

Query: 77  WELK--EEEKKKECAARGEDYEKVKLLEISAEDAER-WERKK-KRKNPDLGFSDYAAAQL 132
            E K  E+++  E   +  ++EK++  E   E  E+ WE++K ++K  +     +   ++
Sbjct: 650 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKM 709

Query: 133 RQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEK 192
           R+   + ++ K   E  E +RE+  EE        +        E+ ++M    EK  E+
Sbjct: 710 REEESMREREKKMREEEEMMREQ--EEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ 767

Query: 193 R 193
           +
Sbjct: 768 Q 768



 Score = 34.7 bits (78), Expect = 0.077
 Identities = 49/216 (22%), Positives = 100/216 (46%), Gaps = 31/216 (14%)

Query: 29  KREQRLR----KFRELH-LMRNEARKLNHQ--EVVEEDKRLKLPANWEAKKARLEWELKE 81
           ++E+RLR    K RE    M  + ++L  Q  E+ E++K L+     E K+ R + E  +
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR-----EQKELREQEEQMQ 351

Query: 82  EEKKKECAARGEDYEKVKLLE--ISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLT 139
           E+++K      E  EK++  E  +  ++   WE++K+ +  +    D       Q  R+ 
Sbjct: 352 EQEEK----MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD-------QEERMW 400

Query: 140 KQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRR 199
           +Q +   E  ER+RE+  E+ +     +     +   E+  R   D E+++++ ++  R 
Sbjct: 401 EQDERLREKEERMREQ--EKMWEQVEKMREEKKMQEQEKKTR---DQEEKMQEEERI-RE 454

Query: 200 RPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQ 235
           R      + + + E+  K  K+ E  + +   E +Q
Sbjct: 455 REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ 490



 Score = 34.3 bits (77), Expect = 0.10
 Identities = 26/98 (26%), Positives = 52/98 (53%), Gaps = 9/98 (9%)

Query: 24  ELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEE 83
           E + ++RE+++R+  E+  MR +  K+  QE   +++  ++   WE ++    WE  +EE
Sbjct: 712 EESMREREKKMREEEEM--MREQEEKMQEQEEKMQEQEEEM---WEQEEKM--WE--QEE 762

Query: 84  KKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPD 121
           K  E     E  EK+   E   E  + WE+++K ++ +
Sbjct: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE 800


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 37.7 bits (86), Expect = 0.009
 Identities = 38/204 (18%), Positives = 95/204 (46%), Gaps = 18/204 (8%)

Query: 30  REQRLRKFRELHLMRNEARKLNHQE--VVEEDKRLKLPANWEAKKARL---EWELKEEEK 84
           REQ  + + +   MR++ +K+  QE  + E+D+RL+       ++ ++   E +++EE+K
Sbjct: 482 REQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKK 541

Query: 85  KKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKP 144
            +E   +  D E     E   E+    ER+KK +  +    +       Q  ++ +Q + 
Sbjct: 542 TQEQEKKTWDQE-----EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEK 596

Query: 145 DMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYND 204
             E  E+++E+  E+ +     +         +E + M+ + E++++++++    +    
Sbjct: 597 MWEQEEKMQEQE-EKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQE--- 652

Query: 205 DADIDYINERNAKFNKKAERFYGK 228
               + + E+  K  ++ E+  G+
Sbjct: 653 ----EKMREQEEKMREQEEKMQGQ 672



 Score = 35.4 bits (80), Expect = 0.045
 Identities = 38/136 (27%), Positives = 68/136 (50%), Gaps = 25/136 (18%)

Query: 29  KREQRLR----KFRELH-LMRNEARKLNHQ--EVVEEDKRLKLPANWEAKKARLEWELKE 81
           ++E+RLR    K RE    MR + ++L  Q  E+ E++K L+     E KK R + E  +
Sbjct: 259 RQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELR-----EQKKLREQEEQMQ 313

Query: 82  EEKKKECAARGEDYEKVKLLE--ISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLT 139
           E+++K      E  EK++  E  +  ++   WE++K+ +  +    D       Q  R+ 
Sbjct: 314 EQEEK----MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD-------QEERMW 362

Query: 140 KQIKPDMETYERLREK 155
           +Q +   E  ER+RE+
Sbjct: 363 EQDERLREKEERMREQ 378



 Score = 31.2 bits (69), Expect = 0.85
 Identities = 33/148 (22%), Positives = 71/148 (47%), Gaps = 24/148 (16%)

Query: 15  EEGSLAAAAELAAQKREQRLRK----FRELHLMRNEARKLNHQEVVEEDKRLKLPANWEA 70
           +EG +    E   +++E+RLR+     RE      E +KL  QE   +++  K+   WE 
Sbjct: 267 QEGKMREQEE-KMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKM---WEQ 322

Query: 71  KKARLEWELK---EEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDY 127
           ++   E E K   +EE+  E   +  + E+    ++  ++   WE+ ++ +  +      
Sbjct: 323 EEKMREQEEKMWRQEERLWEQEKQMREQEQ----KMRDQEERMWEQDERLREKE------ 372

Query: 128 AAAQLRQYHRLTKQIKPDMETYERLREK 155
              ++R+  ++ +Q +  M+  ER+RE+
Sbjct: 373 --ERMREQEKMWEQ-EEKMQEEERIRER 397


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 37.7 bits (86), Expect = 0.009
 Identities = 49/227 (21%), Positives = 100/227 (44%), Gaps = 26/227 (11%)

Query: 8   EVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPAN 67
           E +V S + G +++      ++REQ              + +++H E +EE+ + +    
Sbjct: 222 ETVVMSLKNGQISSEEPKQEEEREQG-------------SDEISHHEKMEEEDKERA--- 265

Query: 68  WEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDY 127
            EA++ARLE E +E  K ++     ++  +++  E +A  A+  ER++  +   +   + 
Sbjct: 266 -EAERARLEAEERERIKAEQDKKIADERARIEAEEKAA--AQERERREAEERERMREEEK 322

Query: 128 AAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLE 187
            AA+ RQ  R+ ++ K   E  +R++E+  E+        +      + EE  R   + E
Sbjct: 323 RAAEERQ--RIKEEEKRAAEERQRIKEE--EKRAAEERQRIKEEEKRAAEERQRARAEEE 378

Query: 188 KQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIK 234
              EK     ++R    +     + E   K  K  ++  GK+  E K
Sbjct: 379 ---EKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKK 422



 Score = 30.4 bits (67), Expect = 1.5
 Identities = 30/103 (29%), Positives = 51/103 (49%), Gaps = 25/103 (24%)

Query: 24  ELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEE 83
           E   QK+++   +  EL   R E RK     V+EE+++ +       K+   + +L+EEE
Sbjct: 552 EKLKQKQQEAALELEELKKKREERRK-----VLEEEEQRR-------KQEEADRKLREEE 599

Query: 84  KKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSD 126
           +K+      E+ E+ +     AE AE     K++K P+ G SD
Sbjct: 600 EKRRLK---EEIERRR-----AEAAE-----KRQKMPEDGLSD 629



 Score = 27.7 bits (60), Expect = 9.4
 Identities = 32/127 (25%), Positives = 52/127 (40%), Gaps = 9/127 (7%)

Query: 5   AASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLK- 63
           AA E     AEE       E  A +  QR+++  +      +  K   +   EE +R+K 
Sbjct: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE 361

Query: 64  --LPANWEAKKARLEWELK---EEEKKK---ECAARGEDYEKVKLLEISAEDAERWERKK 115
               A  E ++AR E E K   EE+K+    E         K+K  ++  +   +W  +K
Sbjct: 362 EEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEK 421

Query: 116 KRKNPDL 122
           K +   L
Sbjct: 422 KAQEDKL 428


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.128    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,808,188
Number of Sequences: 37866
Number of extensions: 406128
Number of successful extensions: 2888
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 324
Number of HSP's that attempted gapping in prelim test: 2158
Number of HSP's gapped (non-prelim): 813
length of query: 243
length of database: 18,247,518
effective HSP length: 99
effective length of query: 144
effective length of database: 14,498,784
effective search space: 2087824896
effective search space used: 2087824896
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.