Search of human proteins with 7657253

Search of human proteins with 7657253

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7657253 T-complex protein 1 [Homo sapiens]
         (557 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7657253 T-complex protein 1 [Homo sapiens]                        1105   0.0  
gi|48762932 chaperonin containing TCP1, subunit 8 (theta) [Homo ...   269   4e-72
gi|63162572 chaperonin containing TCP1, subunit 3 isoform a [Hom...   157   3e-38
gi|24307939 chaperonin containing TCP1, subunit 5 (epsilon) [Hom...   155   1e-37
gi|58761486 chaperonin containing TCP1, subunit 3 isoform b [Hom...   154   2e-37
gi|5453603 chaperonin containing TCP1, subunit 2 [Homo sapiens]       144   3e-34
gi|38455427 chaperonin containing TCP1, subunit 4 (delta) [Homo ...   135   1e-31
gi|4502643 chaperonin containing TCP1, subunit 6A isoform a [Hom...   130   3e-30
gi|5453607 chaperonin containing TCP1, subunit 7 isoform a [Homo...   129   9e-30
gi|58761484 chaperonin containing TCP1, subunit 3 isoform c [Hom...   127   3e-29
gi|57863257 T-complex protein 1 isoform a [Homo sapiens]              122   7e-28
gi|58331173 chaperonin containing TCP1, subunit 6B [Homo sapiens]     119   1e-26
gi|58331171 chaperonin containing TCP1, subunit 6A isoform b [Ho...    86   1e-16
gi|58331185 chaperonin containing TCP1, subunit 7 isoform b [Hom...    77   5e-14
gi|57863259 T-complex protein 1 isoform b [Homo sapiens]               73   6e-13
gi|100816407 Bardet-Biedl syndrome 10 [Homo sapiens]                   47   4e-05
gi|9055272 McKusick-Kaufman syndrome protein [Homo sapiens]            41   0.003
gi|25914754 McKusick-Kaufman syndrome protein [Homo sapiens]           41   0.003
gi|41399285 chaperonin [Homo sapiens]                                  38   0.028
gi|31542947 chaperonin [Homo sapiens]                                  38   0.028
gi|167900484 pentraxin 3 [Homo sapiens]                                34   0.31 
gi|197927448 WD repeat domain 6 protein [Homo sapiens]                 33   0.90 
gi|93141039 nuclear respiratory factor 1 [Homo sapiens]                32   1.2  
gi|93141037 nuclear respiratory factor 1 [Homo sapiens]                32   1.2  
gi|241896898 family with sequence similarity 20, member A [Homo ...    31   2.6  
gi|13162290 betaine-homocysteine methyltransferase 2 [Homo sapiens]    31   3.4  
gi|150456444 hypothetical protein LOC57578 [Homo sapiens]              31   3.4  
gi|19923236 nuclear antigen Sp100 isoform 2 [Homo sapiens]             30   4.5  
gi|169217659 PREDICTED: similar to ectonucleotide pyrophosphatas...    30   5.8  
gi|169167316 PREDICTED: similar to ectonucleotide pyrophosphatas...    30   5.8  

>gi|7657253 T-complex protein 1 [Homo sapiens]
          Length = 557

 Score = 1105 bits (2858), Expect = 0.0
 Identities = 557/557 (100%), Positives = 557/557 (100%)

Query: 1   MDSTVPSALELPQRLALNPRESPRSPEEEEPHLLSSLAAVQTLASVIRPCYGPHGRQKFL 60
           MDSTVPSALELPQRLALNPRESPRSPEEEEPHLLSSLAAVQTLASVIRPCYGPHGRQKFL
Sbjct: 1   MDSTVPSALELPQRLALNPRESPRSPEEEEPHLLSSLAAVQTLASVIRPCYGPHGRQKFL 60

Query: 61  VTMKGETVCTGCATAILRALELEHPAAWLLREAGQTQAENSGDGTAFVVLLTEALLEQAE 120
           VTMKGETVCTGCATAILRALELEHPAAWLLREAGQTQAENSGDGTAFVVLLTEALLEQAE
Sbjct: 61  VTMKGETVCTGCATAILRALELEHPAAWLLREAGQTQAENSGDGTAFVVLLTEALLEQAE 120

Query: 121 QLLKAGLPRPQLREAYATATAEVLATLPSLAIQSLGPLEDPSWALHSVMNTHTLSPMDHL 180
           QLLKAGLPRPQLREAYATATAEVLATLPSLAIQSLGPLEDPSWALHSVMNTHTLSPMDHL
Sbjct: 121 QLLKAGLPRPQLREAYATATAEVLATLPSLAIQSLGPLEDPSWALHSVMNTHTLSPMDHL 180

Query: 181 TKLVAHACWAIKELDGSFKPERVGVCALPGGTLEDSCLLPGLAISGKLCGQMATVLSGAR 240
           TKLVAHACWAIKELDGSFKPERVGVCALPGGTLEDSCLLPGLAISGKLCGQMATVLSGAR
Sbjct: 181 TKLVAHACWAIKELDGSFKPERVGVCALPGGTLEDSCLLPGLAISGKLCGQMATVLSGAR 240

Query: 241 VALFACPFGPAHPNAPATARLSSPADLAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVD 300
           VALFACPFGPAHPNAPATARLSSPADLAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVD
Sbjct: 241 VALFACPFGPAHPNAPATARLSSPADLAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVD 300

Query: 301 EETLTLADKYGIVVIQARSWMEIIYLSEVLDTPLLPRLLPPQRPGKCQRVYRQELGDGLA 360
           EETLTLADKYGIVVIQARSWMEIIYLSEVLDTPLLPRLLPPQRPGKCQRVYRQELGDGLA
Sbjct: 301 EETLTLADKYGIVVIQARSWMEIIYLSEVLDTPLLPRLLPPQRPGKCQRVYRQELGDGLA 360

Query: 361 VVFEWECTGTPALTVVLRGATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALA 420
           VVFEWECTGTPALTVVLRGATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALA
Sbjct: 361 VVFEWECTGTPALTVVLRGATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALA 420

Query: 421 KMLSDKGSRLEGPSGPAFLAFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGV 480
           KMLSDKGSRLEGPSGPAFLAFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGV
Sbjct: 421 KMLSDKGSRLEGPSGPAFLAFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGV 480

Query: 481 GTEGIINVAQEGVWDTLIVKAQGFRAVAEVVLQLVTVDEIVVAKKSPTHQEIWNPDSKKT 540
           GTEGIINVAQEGVWDTLIVKAQGFRAVAEVVLQLVTVDEIVVAKKSPTHQEIWNPDSKKT
Sbjct: 481 GTEGIINVAQEGVWDTLIVKAQGFRAVAEVVLQLVTVDEIVVAKKSPTHQEIWNPDSKKT 540

Query: 541 KKHPPPVETKKILGLNN 557
           KKHPPPVETKKILGLNN
Sbjct: 541 KKHPPPVETKKILGLNN 557


>gi|48762932 chaperonin containing TCP1, subunit 8 (theta) [Homo
           sapiens]
          Length = 548

 Score =  269 bits (688), Expect = 4e-72
 Identities = 169/522 (32%), Positives = 273/522 (52%), Gaps = 17/522 (3%)

Query: 30  EPHLLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWL 89
           E  +  ++ A + LA   R  YGP+G  K ++    +   T  A  ILR LE++HPAA +
Sbjct: 26  EEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKM 85

Query: 90  LREAGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPS 149
           +  A   Q +  GDGT FV++   ALLE AE+LL+ GL   ++ E Y  A  +    LP+
Sbjct: 86  IVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPN 145

Query: 150 LAIQSLGPLEDPSWALHSVMNTHTLSPMD----HLTKLVAHACWAIKELDGSFKPERVGV 205
           L   S   L D    + S++ T  +S        L KL+A AC +I    G F  + + V
Sbjct: 146 LVCCSAKNLRDID-EVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVDNIRV 204

Query: 206 CALPGGTLEDSCLLPGLAISGKLCGQMATVLSGARVALFACPFGPAHPNAPATARLSSPA 265
           C + G  +  S +L G+    +  G + +V   A++A+++CPF         T  + +  
Sbjct: 205 CKILGSGISSSSVLHGMVFKKETEGDVTSV-KDAKIAVYSCPFDGMITETKGTVLIKTAE 263

Query: 266 DLAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVDEETLTLADKYGIVVIQARSWMEIIY 325
           +L  FSKG + L++ QV  +A  G NV V  G+V +  L  A+KY I++++  S  ++  
Sbjct: 264 ELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLRR 323

Query: 326 LSEVLDTPLLPRLLPP--QRPGKCQRVYRQELGDGLAVVFEWECTGTPALTVVLRGATTQ 383
           L + +    LPRL PP  +  G C  VY  E+GD   VVF+ E       T+VLRG+T  
Sbjct: 324 LCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDN 383

Query: 384 GLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGPAFLAFAW 443
            +   E+AV  G++ +  L +D RL+PG GATE+ LAK ++  G    G    A   FA 
Sbjct: 384 LMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAE 443

Query: 444 ALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGVGTE----GIINVAQEGVWDTLIV 499
           A + +P+ LAEN+G+  ++V++++  VHQ GN  +G+  E     + ++ + G+ DT + 
Sbjct: 444 AFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGILDTYLG 503

Query: 500 KAQGFRAVAEVVLQLVTVDEIVVAK-----KSPTHQEIWNPD 536
           K    +      + ++ VD+I++AK     K P+ ++ W+ D
Sbjct: 504 KYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWDDD 545


>gi|63162572 chaperonin containing TCP1, subunit 3 isoform a [Homo
           sapiens]
          Length = 545

 Score =  157 bits (396), Expect = 3e-38
 Identities = 127/513 (24%), Positives = 232/513 (45%), Gaps = 34/513 (6%)

Query: 36  SLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLLREAGQ 95
           ++ A +T+A +IR C GP    K L+   G  V T    AILR ++++HPAA  + E  +
Sbjct: 26  NINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISR 85

Query: 96  TQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSLAIQSL 155
           TQ E  GDGT  V++L   +L  AE  L+  +    +  AY  A  ++++TL  ++I   
Sbjct: 86  TQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPV- 144

Query: 156 GPLEDPSWALHSVMNTHTLSPMDHLTKLVAH-ACWAIKELDGSFKPER-------VGVCA 207
             + D    L+ + ++ T   +   + L  + A  A+K +       +         V  
Sbjct: 145 -DISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQFEENGRKEIDIKKYARVEK 203

Query: 208 LPGGTLEDSCLLPGLAISGKLCG-QMATVLSGARVALFACPFGPAHPNAPATARLSSPAD 266
           +PGG +EDSC+L G+ I+  +   +M   +   R+ L           +     ++   D
Sbjct: 204 IPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREED 263

Query: 267 LAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVDEETLTLADKYGIVVIQARSWMEIIYL 326
             +      Q+ E+ + QL    I +   +   ++    LA  Y +     R+ +  I  
Sbjct: 264 FTRIL----QMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLM-----RANITAIRR 314

Query: 327 SEVLDTPLLPRLLPPQRPGKCQRVYRQELGDGLAVV-----------FEWECTGTPALTV 375
               D   + R    +   + + +   ++G G  ++           F  +C    A T+
Sbjct: 315 VRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTI 374

Query: 376 VLRGATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSG 435
           +LRGA+ + L   E+ +   +     +  DP+L+PG GA+EMA+A  L++K   + G   
Sbjct: 375 LLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQ 434

Query: 436 PAFLAFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNL-LMGVG--TEGIINVAQEG 492
             + A A AL+ +P+TL +N G +   ++  +   H   N    GV   T  ++++ + G
Sbjct: 435 WPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELG 494

Query: 493 VWDTLIVKAQGFRAVAEVVLQLVTVDEIVVAKK 525
           +W+ L VK Q ++   E  + L+ +D+IV   K
Sbjct: 495 IWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHK 527


>gi|24307939 chaperonin containing TCP1, subunit 5 (epsilon) [Homo
           sapiens]
          Length = 541

 Score =  155 bits (391), Expect = 1e-37
 Identities = 123/502 (24%), Positives = 232/502 (46%), Gaps = 16/502 (3%)

Query: 33  LLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLLRE 92
           L S + A + +A+ +R   GP+G  K +V   G+   T     IL  ++++H  A L+ E
Sbjct: 34  LKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVE 93

Query: 93  AGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSLAI 152
             ++Q +  GDGT  VV+L  ALLE+AEQLL  G+   ++ + Y  A    +  L  ++ 
Sbjct: 94  LSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISD 153

Query: 153 QSLGPLEDPSWALHSVMNTHTLSPMD----HLTKLVAHACWAIKELD-GSFKPERVGVCA 207
             L  ++D    + +   T     ++     + ++  +A   + +++      E + V  
Sbjct: 154 SVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEG 213

Query: 208 LPGGTLEDSCLLPGLAISGKLC-GQMATVLSGARVALFACPFGPAHPNAPATARLSSPAD 266
             GG LED+ L+ G+ +       QM   +  A++A+  CPF P  P       ++S  D
Sbjct: 214 KVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVED 273

Query: 267 LAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVDEETLTLADKYGIVVIQARSWMEIIYL 326
                K   +  E+ + Q+   G N+A+     D+E   L  +  +  ++     EI  +
Sbjct: 274 YKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELI 333

Query: 327 SEVLDTPLLPRL--LPPQRPGKCQRVYRQELG---DGLAVVFEWECTGTPALTVVLRGAT 381
           +      ++PR   L  ++ G    V     G   D + V+   +C  + A+T+ +RG  
Sbjct: 334 AIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVI--EQCKNSRAVTIFIRGGN 391

Query: 382 TQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGPAFLAF 441
              +  A+++++  +     L +D R++ G GA E++ A  +S +  +       A  AF
Sbjct: 392 KMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAF 451

Query: 442 AWALKYLPKTLAENAGLAVSDVMAEMSGVH-QGGNLLMGVGT--EGIINVAQEGVWDTLI 498
           A AL+ +P  L+EN+G+     M E+     +  N  +G+    +G  ++ Q+ V +TLI
Sbjct: 452 ADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLI 511

Query: 499 VKAQGFRAVAEVVLQLVTVDEI 520
            K Q      ++V  ++ +D+I
Sbjct: 512 GKKQQISLATQMVRMILKIDDI 533


>gi|58761486 chaperonin containing TCP1, subunit 3 isoform b [Homo
           sapiens]
          Length = 544

 Score =  154 bits (390), Expect = 2e-37
 Identities = 128/513 (24%), Positives = 233/513 (45%), Gaps = 35/513 (6%)

Query: 36  SLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLLREAGQ 95
           ++ A +T+A +IR C GP    K L+   G  V T    AILR ++++HPAA  + E  +
Sbjct: 26  NINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISR 85

Query: 96  TQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSLAIQSL 155
           TQ E  GDGT  V++L E +L  AE  L+  +    +  AY  A  ++++TL  ++I   
Sbjct: 86  TQDEEVGDGTTSVIILGE-MLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPV- 143

Query: 156 GPLEDPSWALHSVMNTHTLSPMDHLTKLVAH-ACWAIKELDGSFKPER-------VGVCA 207
             + D    L+ + ++ T   +   + L  + A  A+K +       +         V  
Sbjct: 144 -DISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQFEENGRKEIDIKKYARVEK 202

Query: 208 LPGGTLEDSCLLPGLAISGKLCG-QMATVLSGARVALFACPFGPAHPNAPATARLSSPAD 266
           +PGG +EDSC+L G+ I+  +   +M   +   R+ L           +     ++   D
Sbjct: 203 IPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREED 262

Query: 267 LAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVDEETLTLADKYGIVVIQARSWMEIIYL 326
             +      Q+ E+ + QL    I +   +   ++    LA  Y +     R+ +  I  
Sbjct: 263 FTRIL----QMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLM-----RANITAIRR 313

Query: 327 SEVLDTPLLPRLLPPQRPGKCQRVYRQELGDGLAVV-----------FEWECTGTPALTV 375
               D   + R    +   + + +   ++G G  ++           F  +C    A T+
Sbjct: 314 VRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTI 373

Query: 376 VLRGATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSG 435
           +LRGA+ + L   E+ +   +     +  DP+L+PG GA+EMA+A  L++K   + G   
Sbjct: 374 LLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQ 433

Query: 436 PAFLAFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNL-LMGVG--TEGIINVAQEG 492
             + A A AL+ +P+TL +N G +   ++  +   H   N    GV   T  ++++ + G
Sbjct: 434 WPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELG 493

Query: 493 VWDTLIVKAQGFRAVAEVVLQLVTVDEIVVAKK 525
           +W+ L VK Q ++   E  + L+ +D+IV   K
Sbjct: 494 IWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHK 526


>gi|5453603 chaperonin containing TCP1, subunit 2 [Homo sapiens]
          Length = 535

 Score =  144 bits (362), Expect = 3e-34
 Identities = 129/518 (24%), Positives = 228/518 (44%), Gaps = 19/518 (3%)

Query: 27  EEEEPHLLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGET--VCTGCATAILRALELEH 84
           E  E   L+S      +  +++   GP G  K L++   +   + T     IL+ + +++
Sbjct: 19  ERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVDN 78

Query: 85  PAAWLLREAGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVL 144
           PAA +L +  + Q +  GDGT  V +L   LL +AE L+   +    +   +  AT    
Sbjct: 79  PAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAR 138

Query: 145 ATLPSLAIQSLGPLEDPSWALHSVMNTHTLSPM-----DHLTKLVAHACWAIKELDGSFK 199
             L S A+            L ++  T   S +     DH TKL   A   +  L GS  
Sbjct: 139 EALLSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEA---VLRLKGSGN 195

Query: 200 PERVGVCALPGGTLEDSCLLPGLAISGKLCGQMATVLSGARVALFACPFGPAHPNA-PAT 258
            E + +    GG+L DS L  G  +  K+       +  A++ +              + 
Sbjct: 196 LEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSR 255

Query: 259 ARLSSPADLAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVDEETLTLADKYGIVVIQAR 318
            R+ S A +A+      + ++++V ++   GIN  +    +      L    G++ I+  
Sbjct: 256 VRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHA 315

Query: 319 SWMEIIYLSEVLDTPLLPRLLPPQ--RPGKCQRVYRQELGDGLAVVFEWECTGTPALTVV 376
            +  +  L+ V    +      P+  + G C+ +    +G+   + F     G  A T+V
Sbjct: 316 DFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGE-ACTIV 374

Query: 377 LRGATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGP 436
           LRGAT Q L  AE++++  +    Q  +D R + G G +EM +A  ++   +R  G    
Sbjct: 375 LRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAV 434

Query: 437 AFLAFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGVG-TEGII-NVAQEGVW 494
           A  ++A AL+ LP  +A+NAG   +D++A++   H  GN   G+   EG I ++A  G+ 
Sbjct: 435 AMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMREGTIGDMAILGIT 494

Query: 495 DTLIVKAQGFRAVAEVVLQLVTVDEIVVA---KKSPTH 529
           ++  VK Q   + AE    ++ VD I+ A   K+ P H
Sbjct: 495 ESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDH 532


>gi|38455427 chaperonin containing TCP1, subunit 4 (delta) [Homo
           sapiens]
          Length = 539

 Score =  135 bits (340), Expect = 1e-31
 Identities = 120/504 (23%), Positives = 220/504 (43%), Gaps = 20/504 (3%)

Query: 35  SSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLLREAG 94
           S+++A + +A  IR   GP G  K +   KG+   T     IL+ +++ HPAA +L E  
Sbjct: 36  SNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELS 95

Query: 95  QTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSLAIQS 154
           + Q   +GDGT  VV++  +LL+   +LL+ G+    + E++  A  + +  L  ++   
Sbjct: 96  KAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPV 155

Query: 155 LGPLEDPSWALHSV---MNTHTLSPMDHLTKLVAHACWAIKELD----GSFKPERVGVCA 207
              L D    L+S    +N+  +S    L   ++     +K +D     S     + +  
Sbjct: 156 --ELSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNA-VMKVIDPATATSVDLRDIKIVK 212

Query: 208 LPGGTLEDSCLLPGLAISGKLCGQMATVLSGARVALFACPFGPAHPNAPATARLSSPADL 267
             GGT++D  L+ GL ++ K+     T +  A++ L          +      +S  A +
Sbjct: 213 KLGGTIDDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQM 272

Query: 268 AQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVDEETLT-----LADKYGIVVIQARSWME 322
            +  +     +   V Q+   G NV ++   +  + L+       +K  I+VI+     +
Sbjct: 273 DRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIERED 332

Query: 323 IIYLSEVLDTPLLPRL--LPPQRPGKCQRVYRQEL-GDGLAVVFEWECTGTPALTVVLRG 379
           I ++ + + T  +  +        G  +      L G G  +      +    +T+V+RG
Sbjct: 333 IEFICKTIGTKPVAHIDQFTADMLGSAELAEEVNLNGSGKLLKITGCASPGKTVTIVVRG 392

Query: 380 ATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGPAFL 439
           +    +  AE++++  +     L +   LI G GA E+ LA  L++    L G       
Sbjct: 393 SNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVR 452

Query: 440 AFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGVGTE--GIINVAQEGVWDTL 497
           AFA A++ +P TLAENAGL     + E+   H  G    G+     GI N+ +E V   L
Sbjct: 453 AFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPL 512

Query: 498 IVKAQGFRAVAEVVLQLVTVDEIV 521
           +V         E V  ++ +D++V
Sbjct: 513 LVSVSALTLATETVRSILKIDDVV 536


>gi|4502643 chaperonin containing TCP1, subunit 6A isoform a [Homo
           sapiens]
          Length = 531

 Score =  130 bits (327), Expect = 3e-30
 Identities = 124/509 (24%), Positives = 215/509 (42%), Gaps = 16/509 (3%)

Query: 33  LLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLLRE 92
           L  +++A + L  V+R   GP G  K LV+  G+   T     +L  ++++HP A L+ +
Sbjct: 20  LAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAK 79

Query: 93  AGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSLAI 152
               Q + +GDGT   VL+   LL+QA+  +  GL    + E +  A  + L  L  + +
Sbjct: 80  VATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEEVKV 139

Query: 153 QSLGPLEDPSWALHSVMNTHTLSPM-DHLTKLVAHACWAIKELDGSFKPERVGVCALPGG 211
                 E       + + T   + + D LT+ V  +  AIK+ D       + +  +   
Sbjct: 140 SREMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMIEIMEMKHK 199

Query: 212 TLEDSCLLPGLAIS-GKLCGQMATVLSGARVALFACPFGPAHPNAPATARLSSPADLAQF 270
           +  D+ L+ GL +  G     M   +  A +               +     S  +  + 
Sbjct: 200 SETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKL 259

Query: 271 SKGSDQLLEKQVGQLAAAGINVA-------VVLGE--VDEETLTLADKYGIVVIQARSWM 321
            K   + +E +V ++      V        VV+ +  +D  +L    K GIV ++     
Sbjct: 260 VKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFSLDALSKEGIVALRRAKRR 319

Query: 322 EIIYLSEVLDTPLLPRL--LPPQRPGKCQRVYRQELGDGLAVVFEWECTGTPALTVVLRG 379
            +  L+       L     L P   G    VY   LG+      E +C    ++T++++G
Sbjct: 320 NMERLTLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIE-KCNNPRSVTLLIKG 378

Query: 380 ATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGPAFL 439
                L   + AV  G+ A      D  ++PGAGA E+A+A+ L      ++G +     
Sbjct: 379 PNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKHKPSVKGRAQLGVQ 438

Query: 440 AFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGV--GTEGIINVAQEGVWDTL 497
           AFA AL  +PK LA+N+G  + + + ++   H     L+GV   T   +  A+ GVWD  
Sbjct: 439 AFADALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMVAAEVGVWDNY 498

Query: 498 IVKAQGFRAVAEVVLQLVTVDEIVVAKKS 526
            VK Q   +   +   ++ VDEI+ A  S
Sbjct: 499 CVKKQLLHSCTVIATNILLVDEIMRAGMS 527


>gi|5453607 chaperonin containing TCP1, subunit 7 isoform a [Homo
           sapiens]
          Length = 543

 Score =  129 bits (323), Expect = 9e-30
 Identities = 117/512 (22%), Positives = 215/512 (41%), Gaps = 22/512 (4%)

Query: 31  PHLLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLL 90
           P L+S+++A Q +A  +R   GP G  K +V  +G+   +     IL+ L++ HPAA  L
Sbjct: 20  PQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTL 79

Query: 91  REAGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSL 150
            +  ++Q    GDGT  V LL    L+Q +  ++ GL    +  A+ TAT   +  +  +
Sbjct: 80  VDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEI 139

Query: 151 A--IQSLGPLED----PSWALHSVMNTHTLSPMDHLTKLVAHACWAIKELDGSFKPERVG 204
           A  ++    +E        A+ ++ +           K+V     A+  LD   + + +G
Sbjct: 140 AVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVD---AVMMLDDLLQLKMIG 196

Query: 205 VCALPGGTLEDSCLLPGLAISGKLC----GQMATVLSGARVALFACPFGPAHPNAPATAR 260
           +  + GG LEDS L+ G+A                    ++AL             A  R
Sbjct: 197 IKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIR 256

Query: 261 LSSPADLAQFSKGSDQLLEKQVGQLAAAGINVA---VVLGEVDEETLTLADKYGIVVIQA 317
           + +  D          +L  ++ ++  +G  V    + +G+V  +     D +    +  
Sbjct: 257 VHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPE 316

Query: 318 RSWME-IIYLSEVLDTPLLPRLLPPQRPGKCQRVYRQELGDGLAVVFEWECTGTPALTVV 376
                 ++     + T +    L     G+CQ     ++G G    F   C      T +
Sbjct: 317 EDLKRTMMACGGSIQTSV--NALSADVLGRCQVFEETQIG-GERYNFFTGCPKAKTCTFI 373

Query: 377 LRGATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGP 436
           LRG   Q +   E++++  I    +  ++  ++ G GA EM L+K L D    + G    
Sbjct: 374 LRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQL 433

Query: 437 AFLAFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGV--GTEGIINVAQEGVW 494
              A+A AL+ +P+ L +NAG   ++++ ++   H  G    GV    E I +  +  VW
Sbjct: 434 LIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEAFVW 493

Query: 495 DTLIVKAQGFRAVAEVVLQLVTVDEIVVAKKS 526
           +  +V+     A +E    +V+VDE +   +S
Sbjct: 494 EPAMVRINALTAASEAACLIVSVDETIKNPRS 525


>gi|58761484 chaperonin containing TCP1, subunit 3 isoform c [Homo
           sapiens]
          Length = 507

 Score =  127 bits (319), Expect = 3e-29
 Identities = 110/469 (23%), Positives = 209/469 (44%), Gaps = 34/469 (7%)

Query: 80  LELEHPAAWLLREAGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATA 139
           ++++HPAA  + E  +TQ E  GDGT  V++L   +L  AE  L+  +    +  AY  A
Sbjct: 32  IQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKA 91

Query: 140 TAEVLATLPSLAIQSLGPLEDPSWALHSVMNTHTLSPMDHLTKLVAH-ACWAIKELDGSF 198
             ++++TL  ++I     + D    L+ + ++ T   +   + L  + A  A+K +    
Sbjct: 92  LDDMISTLKKISIPV--DISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQFEE 149

Query: 199 KPER-------VGVCALPGGTLEDSCLLPGLAISGKLCG-QMATVLSGARVALFACPFGP 250
              +         V  +PGG +EDSC+L G+ I+  +   +M   +   R+ L       
Sbjct: 150 NGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEY 209

Query: 251 AHPNAPATARLSSPADLAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVDEETLTLADKY 310
               +     ++   D  +      Q+ E+ + QL    I +   +   ++    LA  Y
Sbjct: 210 KKGESQTDIEITREEDFTRIL----QMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHY 265

Query: 311 GIVVIQARSWMEIIYLSEVLDTPLLPRLLPPQRPGKCQRVYRQELGDGLAVV-------- 362
            +     R+ +  I      D   + R    +   + + +   ++G G  ++        
Sbjct: 266 LM-----RANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDE 320

Query: 363 ---FEWECTGTPALTVVLRGATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMAL 419
              F  +C    A T++LRGA+ + L   E+ +   +     +  DP+L+PG GA+EMA+
Sbjct: 321 YFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAV 380

Query: 420 AKMLSDKGSRLEGPSGPAFLAFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNL-LM 478
           A  L++K   + G     + A A AL+ +P+TL +N G +   ++  +   H   N    
Sbjct: 381 AHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETW 440

Query: 479 GVG--TEGIINVAQEGVWDTLIVKAQGFRAVAEVVLQLVTVDEIVVAKK 525
           GV   T  ++++ + G+W+ L VK Q ++   E  + L+ +D+IV   K
Sbjct: 441 GVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHK 489


>gi|57863257 T-complex protein 1 isoform a [Homo sapiens]
          Length = 556

 Score =  122 bits (307), Expect = 7e-28
 Identities = 113/514 (21%), Positives = 221/514 (42%), Gaps = 31/514 (6%)

Query: 36  SLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLLREAGQ 95
           ++ A  ++A++++   GP G  K LV   G+   T     IL+ LE+EHPAA +L E   
Sbjct: 21  NVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELAD 80

Query: 96  TQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSLAIQSL 155
            Q +  GDGT  VV++   LL+ A++L+K  +    +   Y  A  E +  +    I + 
Sbjct: 81  LQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYINENLIVNT 140

Query: 156 GPLEDPSWALHSVMNTHTLSPM-----DHLTKLVAHACWAIKELDGSFKP----ERVGVC 206
             L      L +   T   S +     D    +V  A  AIK  D   +P      V + 
Sbjct: 141 DELGRD--CLINAAKTSMSSKIIGINGDFFANMVVDAVLAIKYTDIRGQPRYPVNSVNIL 198

Query: 207 ALPGGTLEDSCLLPGLAISGKLCGQ-MATVLSGARVALFACPFGPAHPNAPATARLSSPA 265
              G +  +S L+ G A++  +  Q M   +  A++A                  ++ P 
Sbjct: 199 KAHGRSQMESMLISGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPE 258

Query: 266 DLAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVDEETLTLADKYGIVVIQARSWMEIIY 325
            L Q  +    + ++++ ++ A G NV +  G +D+  L    + G + ++     ++  
Sbjct: 259 KLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKR 318

Query: 326 LSEVLDTPLLPRL--------LPPQRPGKCQRVYRQELGDGLAVVFEWECTGTPALTVVL 377
           +++     +L  L              G+ + V ++ + D   ++ +     T A +++L
Sbjct: 319 IAKASGATILSTLANLEGEETFEAAMLGQAEEVVQERICDDELILIKNTKARTSA-SIIL 377

Query: 378 RGATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGPA 437
           RGA        E++++  +    ++ +   ++PG GA E AL+  L +  + +      A
Sbjct: 378 RGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLA 437

Query: 438 FLAFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNL------LMGVGTE----GIIN 487
              FA +L  +P TLA NA    +D++A++   H    +      L  +G +       +
Sbjct: 438 IAEFARSLLVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLSNGKPRD 497

Query: 488 VAQEGVWDTLIVKAQGFRAVAEVVLQLVTVDEIV 521
             Q GV++  IVK +  +   E  + ++ +D+++
Sbjct: 498 NKQAGVFEPTIVKVKSLKFATEAAITILRIDDLI 531


>gi|58331173 chaperonin containing TCP1, subunit 6B [Homo sapiens]
          Length = 530

 Score =  119 bits (297), Expect = 1e-26
 Identities = 120/509 (23%), Positives = 213/509 (41%), Gaps = 16/509 (3%)

Query: 33  LLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLLRE 92
           L  ++ A + L  V+R   GP G  K LV+  G+   T     +L  ++++HP A L+ +
Sbjct: 20  LAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLDEMQIQHPTASLIAK 79

Query: 93  AGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSLAI 152
               Q + +GDGT   VL+   LL+QA+  +  GL    + E +  A  + L  L  + +
Sbjct: 80  VATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIKALEVLEEVKV 139

Query: 153 QSLGPLEDPSWALHSVMNTHTLSPM-DHLTKLVAHACWAIKELDGSFKPERVGVCALPGG 211
                 +       + + T   + + D LT++V  +  A++          V +  +   
Sbjct: 140 TKEMKRKILLDVARTSLQTKVHAELADVLTEVVVDSVLAVRRPGYPIDLFMVEIMEMKHK 199

Query: 212 TLEDSCLLPGLAIS-GKLCGQMATVLSGARVALFACPFGPAHPNAPATARLSSPADLAQF 270
              D+ L+ GL +  G     M   +  A + +             +     +  +  + 
Sbjct: 200 LGTDTKLIQGLVLDHGARHPDMKKRVEDAFILICNVSLEYEKTEVNSGFFYKTAEEKEKL 259

Query: 271 SKGSDQLLEKQVGQLAAAGINVA-------VVLGE--VDEETLTLADKYGIVVIQARSWM 321
            K   + +E +V ++      V        VV+ +  +D  +L    K+GIV ++     
Sbjct: 260 VKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDSLAKHGIVALRRAKRR 319

Query: 322 EIIYLSEVLDTPLLPRL--LPPQRPGKCQRVYRQELGDGLAVVFEWECTGTPALTVVLRG 379
            +  LS       +     L     G    VY   LG+      E EC    ++T++++G
Sbjct: 320 NMERLSLACGGMAVNSFEDLTVDCLGHAGLVYEYTLGEEKFTFIE-ECVNPCSVTLLVKG 378

Query: 380 ATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGPAFL 439
                L   + A+  G+ A     +D  ++PGAGA E+A+A+ L    + ++G +     
Sbjct: 379 PNKHTLTQVKDAIRDGLRAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRARLGVQ 438

Query: 440 AFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGV--GTEGIINVAQEGVWDTL 497
           AFA AL  +PK LA+NAG    + + ++   H     L+GV   T   +  A  GVWD  
Sbjct: 439 AFADALLIIPKVLAQNAGYDPQETLVKVQAEHVESKQLVGVDLNTGEPMVAADAGVWDNY 498

Query: 498 IVKAQGFRAVAEVVLQLVTVDEIVVAKKS 526
            VK Q   +   +   ++ VDEI+ A  S
Sbjct: 499 CVKKQLLHSCTVIATNILLVDEIMRAGMS 527


>gi|58331171 chaperonin containing TCP1, subunit 6A isoform b [Homo
           sapiens]
          Length = 486

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 116/508 (22%), Positives = 195/508 (38%), Gaps = 59/508 (11%)

Query: 33  LLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLLRE 92
           L  +++A + L  V+R   GP G  K LV+  G+   T     +L  + L HP       
Sbjct: 20  LAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMGL-HPR------ 72

Query: 93  AGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSLAI 152
                            ++TE      E+ L       Q  E    +      TL  +A 
Sbjct: 73  -----------------IITEGFEAAKEKAL-------QFLEEVKVSREMDRETLIDVAR 108

Query: 153 QSLGPLEDPSWALHSVMNTHTLSPMDHLTKLVAHACWAIKELDGSFKPERVGVCALPGGT 212
            SL         +H+ +        D LT+ V  +  AIK+ D       + +  +   +
Sbjct: 109 TSLRT------KVHAEL-------ADVLTEAVVDSILAIKKQDEPIDLFMIEIMEMKHKS 155

Query: 213 LEDSCLLPGLAIS-GKLCGQMATVLSGARVALFACPFGPAHPNAPATARLSSPADLAQFS 271
             D+ L+ GL +  G     M   +  A +               +     S  +  +  
Sbjct: 156 ETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLV 215

Query: 272 KGSDQLLEKQVGQLAAAGINVA-------VVLGE--VDEETLTLADKYGIVVIQARSWME 322
           K   + +E +V ++      V        VV+ +  +D  +L    K GIV ++      
Sbjct: 216 KAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFSLDALSKEGIVALRRAKRRN 275

Query: 323 IIYLSEVLDTPLLPRL--LPPQRPGKCQRVYRQELGDGLAVVFEWECTGTPALTVVLRGA 380
           +  L+       L     L P   G    VY   LG+      E +C    ++T++++G 
Sbjct: 276 MERLTLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIE-KCNNPRSVTLLIKGP 334

Query: 381 TTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGPAFLA 440
               L   + AV  G+ A      D  ++PGAGA E+A+A+ L      ++G +     A
Sbjct: 335 NKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKHKPSVKGRAQLGVQA 394

Query: 441 FAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGV--GTEGIINVAQEGVWDTLI 498
           FA AL  +PK LA+N+G  + + + ++   H     L+GV   T   +  A+ GVWD   
Sbjct: 395 FADALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMVAAEVGVWDNYC 454

Query: 499 VKAQGFRAVAEVVLQLVTVDEIVVAKKS 526
           VK Q   +   +   ++ VDEI+ A  S
Sbjct: 455 VKKQLLHSCTVIATNILLVDEIMRAGMS 482


>gi|58331185 chaperonin containing TCP1, subunit 7 isoform b [Homo
           sapiens]
          Length = 339

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 49/184 (26%), Positives = 86/184 (46%), Gaps = 3/184 (1%)

Query: 345 GKCQRVYRQELGDGLAVVFEWECTGTPALTVVLRGATTQGLRSAEQAVYHGIDAYFQLCQ 404
           G+CQ     ++G G    F   C      T +LRG   Q +   E++++  I    +  +
Sbjct: 139 GRCQVFEETQIG-GERYNFFTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIK 197

Query: 405 DPRLIPGAGATEMALAKMLSDKGSRLEGPSGPAFLAFAWALKYLPKTLAENAGLAVSDVM 464
           +  ++ G GA EM L+K L D    + G       A+A AL+ +P+ L +NAG   ++++
Sbjct: 198 NDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNIL 257

Query: 465 AEMSGVHQGGNLLMGV--GTEGIINVAQEGVWDTLIVKAQGFRAVAEVVLQLVTVDEIVV 522
            ++   H  G    GV    E I +  +  VW+  +V+     A +E    +V+VDE + 
Sbjct: 258 NKLRARHAQGGTWYGVDINNEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIK 317

Query: 523 AKKS 526
             +S
Sbjct: 318 NPRS 321


>gi|57863259 T-complex protein 1 isoform b [Homo sapiens]
          Length = 401

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 72/367 (19%), Positives = 155/367 (42%), Gaps = 24/367 (6%)

Query: 178 DHLTKLVAHACWAIKELDGSFKPE----RVGVCALPGGTLEDSCLLPGLAISGKLCGQ-M 232
           D    +V  A  AIK  D   +P      V +    G +  +S L+ G A++  +  Q M
Sbjct: 11  DFFANMVVDAVLAIKYTDIRGQPRYPVNSVNILKAHGRSQMESMLISGYALNCVVGSQGM 70

Query: 233 ATVLSGARVALFACPFGPAHPNAPATARLSSPADLAQFSKGSDQLLEKQVGQLAAAGINV 292
              +  A++A                  ++ P  L Q  +    + ++++ ++ A G NV
Sbjct: 71  PKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANV 130

Query: 293 AVVLGEVDEETLTLADKYGIVVIQARSWMEIIYLSEVLDTPLLPRLLPPQRP-------- 344
            +  G +D+  L    + G + ++     ++  +++     +L  L   +          
Sbjct: 131 ILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGATILSTLANLEGEETFEAAML 190

Query: 345 GKCQRVYRQELGDGLAVVFEWECTGTPALTVVLRGATTQGLRSAEQAVYHGIDAYFQLCQ 404
           G+ + V ++ + D   ++ +     T A +++LRGA        E++++  +    ++ +
Sbjct: 191 GQAEEVVQERICDDELILIKNTKARTSA-SIILRGANDFMCDEMERSLHDALCVVKRVLE 249

Query: 405 DPRLIPGAGATEMALAKMLSDKGSRLEGPSGPAFLAFAWALKYLPKTLAENAGLAVSDVM 464
              ++PG GA E AL+  L +  + +      A   FA +L  +P TLA NA    +D++
Sbjct: 250 SKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPNTLAVNAAQDSTDLV 309

Query: 465 AEMSGVHQGGNL------LMGVGTE----GIINVAQEGVWDTLIVKAQGFRAVAEVVLQL 514
           A++   H    +      L  +G +       +  Q GV++  IVK +  +   E  + +
Sbjct: 310 AKLRAFHNEAQVNPERKNLKWIGLDLSNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITI 369

Query: 515 VTVDEIV 521
           + +D+++
Sbjct: 370 LRIDDLI 376


>gi|100816407 Bardet-Biedl syndrome 10 [Homo sapiens]
          Length = 723

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 24/82 (29%), Positives = 41/82 (50%), Gaps = 1/82 (1%)

Query: 35  SSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLLREAG 94
           ++L   + L +++  C GP GRQ       GE + +     +L AL LEHP A ++ +  
Sbjct: 13  AALQVAEVLEAIVSCCVGPEGRQVLCTKPTGEVLLSRNGGRLLEALHLEHPIARMIVDCV 72

Query: 95  QTQAENSGDGT-AFVVLLTEAL 115
            +  + +GDG   F++ L   L
Sbjct: 73  SSHLKKTGDGAKTFIIFLCHLL 94


>gi|9055272 McKusick-Kaufman syndrome protein [Homo sapiens]
          Length = 570

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 1/84 (1%)

Query: 40  VQTLASVIRPCYGPHGRQKFLVTMKGETVC-TGCATAILRALELEHPAAWLLREAGQTQA 98
           +  L  ++  CYGP GR K L    G  VC T  ++A+L  L + HP   +L  + Q   
Sbjct: 26  LSVLKRIVTSCYGPSGRLKQLHNGFGGYVCTTSQSSALLSHLLVTHPILKILTASIQNHV 85

Query: 99  ENSGDGTAFVVLLTEALLEQAEQL 122
            +  D   F  +L   L+E  ++L
Sbjct: 86  SSFSDCGLFTAILCCNLIENVQRL 109


>gi|25914754 McKusick-Kaufman syndrome protein [Homo sapiens]
          Length = 570

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 1/84 (1%)

Query: 40  VQTLASVIRPCYGPHGRQKFLVTMKGETVC-TGCATAILRALELEHPAAWLLREAGQTQA 98
           +  L  ++  CYGP GR K L    G  VC T  ++A+L  L + HP   +L  + Q   
Sbjct: 26  LSVLKRIVTSCYGPSGRLKQLHNGFGGYVCTTSQSSALLSHLLVTHPILKILTASIQNHV 85

Query: 99  ENSGDGTAFVVLLTEALLEQAEQL 122
            +  D   F  +L   L+E  ++L
Sbjct: 86  SSFSDCGLFTAILCCNLIENVQRL 109


>gi|41399285 chaperonin [Homo sapiens]
          Length = 573

 Score = 37.7 bits (86), Expect = 0.028
 Identities = 25/115 (21%), Positives = 47/115 (40%), Gaps = 4/115 (3%)

Query: 37  LAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHP----AAWLLRE 92
           L  V  LA  +    GP GR   +    G    T     + ++++L+       A L+++
Sbjct: 41  LQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQD 100

Query: 93  AGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATL 147
                 E +GDGT    +L  ++ ++  + +  G    ++R     A   V+A L
Sbjct: 101 VANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAEL 155


>gi|31542947 chaperonin [Homo sapiens]
          Length = 573

 Score = 37.7 bits (86), Expect = 0.028
 Identities = 25/115 (21%), Positives = 47/115 (40%), Gaps = 4/115 (3%)

Query: 37  LAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHP----AAWLLRE 92
           L  V  LA  +    GP GR   +    G    T     + ++++L+       A L+++
Sbjct: 41  LQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQD 100

Query: 93  AGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATL 147
                 E +GDGT    +L  ++ ++  + +  G    ++R     A   V+A L
Sbjct: 101 VANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAEL 155


>gi|167900484 pentraxin 3 [Homo sapiens]
          Length = 381

 Score = 34.3 bits (77), Expect = 0.31
 Identities = 28/77 (36%), Positives = 40/77 (51%), Gaps = 8/77 (10%)

Query: 250 PAHPNAPATARLSSPAD-LAQFSKGSDQLLEKQVGQLA----AAGINVAVVLGEVDEETL 304
           P  P APA ARL+S  D L Q ++ + + L +  G  A     AG  +A VL E+ +   
Sbjct: 102 PCAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQ--- 158

Query: 305 TLADKYGIVVIQARSWM 321
           T AD + +    ARSW+
Sbjct: 159 TRADLHAVQGWAARSWL 175


>gi|197927448 WD repeat domain 6 protein [Homo sapiens]
          Length = 1151

 Score = 32.7 bits (73), Expect = 0.90
 Identities = 36/132 (27%), Positives = 51/132 (38%), Gaps = 16/132 (12%)

Query: 91   REAGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLRE--------AYATATAE 142
            RE     A  S DG+  V +L   +L+  E + +AGL  PQLR         A+A     
Sbjct: 1022 REGHHLVASGSEDGSLHVFVLAVEMLQLEEAVGEAGLV-PQLRVLEEYSVPCAHAAHVTG 1080

Query: 143  VLATLPSLAIQSLGPLEDPSWALHSVMNTHTLSPMDHLTKLVAHACWAIKELDGSFKPER 202
            +    PS+ + +        W L     T   S + H+  +    CW +        PE 
Sbjct: 1081 LKILSPSIMVSASIDQRLTFWRLGHGEPTFMNSTVFHVPDVADMDCWPV-------SPEF 1133

Query: 203  VGVCALPGGTLE 214
               CAL G  LE
Sbjct: 1134 GHRCALGGQGLE 1145


>gi|93141039 nuclear respiratory factor 1 [Homo sapiens]
          Length = 503

 Score = 32.3 bits (72), Expect = 1.2
 Identities = 62/267 (23%), Positives = 101/267 (37%), Gaps = 39/267 (14%)

Query: 18  NPRESPRSPEEEEPHLLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAIL 77
           N R   R+ E+++      ++  Q L ++++ CY  HGR+  L   + +   T  ATA  
Sbjct: 242 NVRSDVRTEEQKQ-----RVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQ-ATA-- 293

Query: 78  RALELEHPAAWLLREAGQTQAENSGDGTAFVVLL----TEALLEQAEQLLK--------- 124
                 H  A L+      Q  ++ DGT  ++ +    T A L  A +L           
Sbjct: 294 -----THSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNY 348

Query: 125 AGLPRPQLREAYAT---ATAEVLATLPSLAIQSLGPLEDPSWALHSVMNTHTLSPMDHLT 181
           + +   ++ + +AT       +  T  S A Q++  L + + A    M       M   +
Sbjct: 349 SAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNS 408

Query: 182 KLVAHACWAIKE--LDGSFKPERVGVCALPGGTLEDSCLLPGLAISGKLCGQMATVLSGA 239
           +  AHA   + E  L G       G   L G T      L G+  +  L  Q+   +   
Sbjct: 409 EAAAHAVATLAEATLQGG------GQIVLSGETAAAVGALTGVQDANGLV-QIPVSMYQT 461

Query: 240 RVALFACPFGPAH-PNAPATARLSSPA 265
            V   A   GP     AP T R+S  A
Sbjct: 462 VVTSLAQGNGPVQVAMAPVTTRISDSA 488


>gi|93141037 nuclear respiratory factor 1 [Homo sapiens]
          Length = 503

 Score = 32.3 bits (72), Expect = 1.2
 Identities = 62/267 (23%), Positives = 101/267 (37%), Gaps = 39/267 (14%)

Query: 18  NPRESPRSPEEEEPHLLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAIL 77
           N R   R+ E+++      ++  Q L ++++ CY  HGR+  L   + +   T  ATA  
Sbjct: 242 NVRSDVRTEEQKQ-----RVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQ-ATA-- 293

Query: 78  RALELEHPAAWLLREAGQTQAENSGDGTAFVVLL----TEALLEQAEQLLK--------- 124
                 H  A L+      Q  ++ DGT  ++ +    T A L  A +L           
Sbjct: 294 -----THSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNY 348

Query: 125 AGLPRPQLREAYAT---ATAEVLATLPSLAIQSLGPLEDPSWALHSVMNTHTLSPMDHLT 181
           + +   ++ + +AT       +  T  S A Q++  L + + A    M       M   +
Sbjct: 349 SAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNS 408

Query: 182 KLVAHACWAIKE--LDGSFKPERVGVCALPGGTLEDSCLLPGLAISGKLCGQMATVLSGA 239
           +  AHA   + E  L G       G   L G T      L G+  +  L  Q+   +   
Sbjct: 409 EAAAHAVATLAEATLQGG------GQIVLSGETAAAVGALTGVQDANGLV-QIPVSMYQT 461

Query: 240 RVALFACPFGPAH-PNAPATARLSSPA 265
            V   A   GP     AP T R+S  A
Sbjct: 462 VVTSLAQGNGPVQVAMAPVTTRISDSA 488


>gi|241896898 family with sequence similarity 20, member A [Homo
           sapiens]
          Length = 541

 Score = 31.2 bits (69), Expect = 2.6
 Identities = 15/41 (36%), Positives = 21/41 (51%)

Query: 21  ESPRSPEEEEPHLLSSLAAVQTLASVIRPCYGPHGRQKFLV 61
           E   SP   EPHLL+    +QT+   +  C   HG+Q  +V
Sbjct: 483 EDQLSPVLTEPHLLALDRRLQTILRTVEGCIVAHGQQSVIV 523


>gi|13162290 betaine-homocysteine methyltransferase 2 [Homo sapiens]
          Length = 363

 Score = 30.8 bits (68), Expect = 3.4
 Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 9/67 (13%)

Query: 184 VAHACWAIKELDGSFKPERVGVCALPGGTLEDSCLLPGLAISGKLCGQMATVLSGARVAL 243
           V  A WA++ L  S +P  V +C  P G + D  + PG          +  V +GA +  
Sbjct: 155 VEEAVWAVEVLKESDRPVAVTMCIGPEGDMHD--ITPGEC-------AVRLVKAGASIVG 205

Query: 244 FACPFGP 250
             C FGP
Sbjct: 206 VNCRFGP 212


>gi|150456444 hypothetical protein LOC57578 [Homo sapiens]
          Length = 2458

 Score = 30.8 bits (68), Expect = 3.4
 Identities = 25/81 (30%), Positives = 40/81 (49%), Gaps = 9/81 (11%)

Query: 255  APATARLSSPADLAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVDEETLTLADKYGIVV 314
            A  ++ LS+P+ ++ F    ++  ++Q   +     +   +L E DEETL LA    IVV
Sbjct: 1797 ATKSSLLSAPSIVSMFVPAPEEFTDEQPTVMTDKCHDCGAILEEYDEETLGLA----IVV 1852

Query: 315  IQARSWMEIIYLSEVLDTPLL 335
            +        I+LS  L  PLL
Sbjct: 1853 LST-----FIHLSPDLAAPLL 1868


>gi|19923236 nuclear antigen Sp100 isoform 2 [Homo sapiens]
          Length = 879

 Score = 30.4 bits (67), Expect = 4.5
 Identities = 12/38 (31%), Positives = 22/38 (57%)

Query: 433 PSGPAFLAFAWALKYLPKTLAENAGLAVSDVMAEMSGV 470
           P  P    F +  +Y PK   E+ GL++ DV+ +++G+
Sbjct: 769 PKRPPLAFFLFCSEYRPKIKGEHPGLSIDDVVKKLAGM 806


>gi|169217659 PREDICTED: similar to ectonucleotide
           pyrophosphatase/phosphodiesterase 5 [Homo sapiens]
          Length = 542

 Score = 30.0 bits (66), Expect = 5.8
 Identities = 23/56 (41%), Positives = 26/56 (46%), Gaps = 5/56 (8%)

Query: 229 CGQMATVLSGARVALFACPF-GPAHPNAPATARLSSPADLAQFSKGSDQLLEKQVG 283
           C Q AT L+ +   L   P+ GPA    P TA L SP DL Q S     LL    G
Sbjct: 329 CLQDATNLNASEAQLPGSPYPGPA----PGTANLDSPQDLPQQSAPRTHLLTVSPG 380


>gi|169167316 PREDICTED: similar to ectonucleotide
           pyrophosphatase/phosphodiesterase 5 [Homo sapiens]
          Length = 542

 Score = 30.0 bits (66), Expect = 5.8
 Identities = 23/56 (41%), Positives = 26/56 (46%), Gaps = 5/56 (8%)

Query: 229 CGQMATVLSGARVALFACPF-GPAHPNAPATARLSSPADLAQFSKGSDQLLEKQVG 283
           C Q AT L+ +   L   P+ GPA    P TA L SP DL Q S     LL    G
Sbjct: 329 CLQDATNLNASEAQLPGSPYPGPA----PGTANLDSPQDLPQQSAPRTHLLTVSPG 380


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,611,849
Number of Sequences: 37866
Number of extensions: 1036876
Number of successful extensions: 2786
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2729
Number of HSP's gapped (non-prelim): 42
length of query: 557
length of database: 18,247,518
effective HSP length: 107
effective length of query: 450
effective length of database: 14,195,856
effective search space: 6388135200
effective search space used: 6388135200
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.