Search of human proteins with 7657214

Search of human proteins with 7657214

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
         (714 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa...  1454   0.0  
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   233   4e-61
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   228   1e-59
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...   225   1e-58
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...   224   2e-58
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   222   8e-58
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   222   8e-58
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   222   8e-58
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   222   8e-58
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...   221   2e-57
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...   221   2e-57
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...   220   3e-57
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   203   4e-52
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub...   201   2e-51
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]        199   6e-51
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]    197   4e-50
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         196   5e-50
gi|116256471 SNF1-like kinase [Homo sapiens]                          196   8e-50
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               193   4e-49
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub...   192   1e-48
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]              191   2e-48
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               177   2e-44
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]       176   9e-44
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor...   172   7e-43
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo...   172   7e-43
gi|156105707 SNF related kinase [Homo sapiens]                        169   8e-42
gi|156105705 SNF related kinase [Homo sapiens]                        169   8e-42
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo...   166   7e-41
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]           166   9e-41
gi|14042947 testis-specific serine kinase 1 [Homo sapiens]            164   2e-40

>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
           sapiens]
          Length = 714

 Score = 1454 bits (3763), Expect = 0.0
 Identities = 714/714 (100%), Positives = 714/714 (100%)

Query: 1   MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGN 60
           MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGN
Sbjct: 1   MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGN 60

Query: 61  YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH 120
           YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH
Sbjct: 61  YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH 120

Query: 121 PNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRA 180
           PNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRA
Sbjct: 121 PNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRA 180

Query: 181 GVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY 240
           GVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY
Sbjct: 181 GVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY 240

Query: 241 GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSL 300
           GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSL
Sbjct: 241 GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSL 300

Query: 301 LEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNS 360
           LEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNS
Sbjct: 301 LEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNS 360

Query: 361 DVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEA 420
           DVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEA
Sbjct: 361 DVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEA 420

Query: 421 SLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKA 480
           SLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKA
Sbjct: 421 SLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKA 480

Query: 481 LLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQP 540
           LLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQP
Sbjct: 481 LLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQP 540

Query: 541 GPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLS 600
           GPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLS
Sbjct: 541 GPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLS 600

Query: 601 PGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSR 660
           PGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSR
Sbjct: 601 PGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSR 660

Query: 661 GRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC 714
           GRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC
Sbjct: 661 GRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC 714


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  233 bits (595), Expect = 4e-61
 Identities = 131/355 (36%), Positives = 217/355 (61%), Gaps = 16/355 (4%)

Query: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
           D Q H  +GNY +  + +G+G+FAKV+   HVLTG +VA+K+IDK +    +   + L R
Sbjct: 52  DEQPH--IGNYRL-QKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSL--QKLFR 106

Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
           E +I +++ HPNI +L +++ETE + YLVME   GG +   +    R++E EAR   RQ+
Sbjct: 107 EVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 166

Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN   +    D F   CGSP YA
Sbjct: 167 VSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTF---CGSPPYA 223

Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 224 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 280

Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
           ST   + L+ LL  +P+KR +++Q + +RW+N  +  +     T P+     D + +  +
Sbjct: 281 STDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPD----PDFNDTKRI 336

Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTR 404
            +   +G+   ++ + +++ +   ++A Y LL +K   +  G+S    +LC ++R
Sbjct: 337 DIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSR 391


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  228 bits (582), Expect = 1e-59
 Identities = 136/378 (35%), Positives = 211/378 (55%), Gaps = 19/378 (5%)

Query: 15  APGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDF-----QHHKRVGNYLIGSRKLG 69
           APG    ++      +       P+W S     R R+      +    VGNY +  R +G
Sbjct: 8   APGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRL-LRTIG 66

Query: 70  EGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDI 129
           +G+FAKV+   H+LTG +VAIK+IDK +    +   + L RE +I + + HPNI +L ++
Sbjct: 67  KGNFAKVKLARHILTGREVAIKIIDKTQLNPSSL--QKLFREVRIMKGLNHPNIVKLFEV 124

Query: 130 LETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKI 189
           +ETE + YLVME    G +   +    R++E EAR   RQ++SAV + H+  +VHRDLK 
Sbjct: 125 IETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKA 184

Query: 190 ENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWS 248
           ENLLLD + NIK+ DFG SN   +    D F   CGSP YAAPEL   KKY GP++D+WS
Sbjct: 185 ENLLLDAEANIKIADFGFSNEFTLGSKLDTF---CGSPPYAAPELFQGKKYDGPEVDIWS 241

Query: 249 IGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKR 308
           +GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +ST   S LR  L  +P KR
Sbjct: 242 LGVILYTLVSGSLPF--DGHNLKELRERVLRGKYR-VPFYMSTDCESILRRFLVLNPAKR 298

Query: 309 PNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLS 368
             ++Q + ++W+N  Y G+     T P     ED   +  + +   +GY   ++  ++ S
Sbjct: 299 CTLEQIMKDKWINIGYEGEELKPYTEPE----EDFGDTKRIEVMVGMGYTREEIKESLTS 354

Query: 369 NRACHILAIYFLLNKKLE 386
            +   + A Y LL +K E
Sbjct: 355 QKYNEVTATYLLLGRKTE 372


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score =  225 bits (573), Expect = 1e-58
 Identities = 179/621 (28%), Positives = 288/621 (46%), Gaps = 91/621 (14%)

Query: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG++VA+K+IDK +    +   + L R
Sbjct: 12  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 66

Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
           E +I +++ HPNI +L +++ETE + YLVME   GG +   +    R++E EAR   RQ+
Sbjct: 67  EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 126

Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN      + +   T CGSP YA
Sbjct: 127 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 183

Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 184 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 240

Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
           ST   + L+  L  +P KR  ++Q + +RW+N  +      +   P    L D       
Sbjct: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 296

Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTR-LYQI 408
            +   +GY   ++ ++++  R   ++A Y LL  K    L G     D++  K R    +
Sbjct: 297 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSE-LEG-----DTITLKPRPSADL 350

Query: 409 EKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFL--HRPFSKKLDKNLPSHKQ 466
               AP  S++             +   K+ +  ++ G  +     +SKK   N   +K+
Sbjct: 351 TNSSAPSPSHKVQRSV--------SANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKR 402

Query: 467 PSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPP 526
           P               +DR++ +                        ASS+ +    P P
Sbjct: 403 PE--------------EDRESGRK-----------------------ASSTAKVPASPLP 425

Query: 527 RTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSP 586
              R    P P      ST      +  +L+     ++          S  +    L  P
Sbjct: 426 GLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQA----------SIQNGKDSLTMP 475

Query: 587 VSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNG 646
            S A   S+   +S   P      +   +HP   S        PP E    C  P PS  
Sbjct: 476 GSRASTASASAAVSAARPRQHQKSMSASVHPNKAS------GLPPTESN--CEVPRPSTA 527

Query: 647 PMQ-PLGSPNC--VKSRGRFP 664
           P + P+ SP+   + S G  P
Sbjct: 528 PQRVPVASPSAHNISSSGGAP 548


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score =  224 bits (571), Expect = 2e-58
 Identities = 179/619 (28%), Positives = 286/619 (46%), Gaps = 86/619 (13%)

Query: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG++VA+K+IDK +    +   + L R
Sbjct: 45  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 99

Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
           E +I +++ HPNI +L +++ETE + YLVME   GG +   +    R++E EAR   RQ+
Sbjct: 100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159

Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN      + +   T CGSP YA
Sbjct: 160 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 216

Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 273

Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
           ST   + L+  L  +P KR  ++Q + +RW+N  +      +   P    L D       
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 329

Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTR-LYQI 408
            +   +GY   ++ ++++  R   ++A Y LL  K    L G     D++  K R    +
Sbjct: 330 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSE-LEG-----DTITLKPRPSADL 383

Query: 409 EKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPS 468
               AP  S++       R +  +  Q +   +           +SKK   N   +K+P 
Sbjct: 384 TNSSAPSPSHKVQ-----RSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPE 438

Query: 469 GSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRT 528
                         +DR++ +                        ASS+ +    P P  
Sbjct: 439 --------------EDRESGRK-----------------------ASSTAKVPASPLPGL 461

Query: 529 PRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVS 588
            R    P P      ST      +  +L+     ++          S  +    L  P S
Sbjct: 462 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQA----------SIQNGKDSLTMPGS 511

Query: 589 LARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPM 648
            A   S+   +S   P      +   +HP   S        PP E    C  P PS  P 
Sbjct: 512 RASTASASAAVSAARPRQHQKSMSASVHPNKAS------GLPPTESN--CEVPRPSTAPQ 563

Query: 649 Q-PLGSPNC--VKSRGRFP 664
           + P+ SP+   + S G  P
Sbjct: 564 RVPVASPSAHNISSSGGAP 582


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  222 bits (566), Expect = 8e-58
 Identities = 160/509 (31%), Positives = 257/509 (50%), Gaps = 65/509 (12%)

Query: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG +VAIK+IDK +    +   + L R
Sbjct: 48  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL--QKLFR 102

Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
           E +I +++ HPNI +L +++ETE + YL+ME   GG +   +    R++E EAR   RQ+
Sbjct: 103 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 162

Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN   + G  D F   CGSP YA
Sbjct: 163 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF---CGSPPYA 219

Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 276

Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
           ST   + L+  L  +P+KR  ++Q + +RW+N  +          P      D+S    +
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPEL----DISDQKRI 332

Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSL------CYKT 403
            +   +GY   ++  ++   +   I A Y LL +K    +   SD+ +S         + 
Sbjct: 333 DIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSE-VRPSSDLNNSTGQSPHHKVQR 391

Query: 404 RLYQIEKYRA---------------PKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDF 448
            ++  +K R                PK S  ++ D+   DL+   +  +K       G  
Sbjct: 392 SVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADS---DLKEDGISSRKSSGSAVGGKG 448

Query: 449 LHRPFSKKLDKNLPSHKQPSGSLMTQIQN-TKALLKDRKASK---SSFPDKDSFGCRNIF 504
           +                 P+  ++    N  KA + +RK S    SS         RN +
Sbjct: 449 I----------------APASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTY 492

Query: 505 ----RKTSDSNCVASSSMEFIPVPPPRTP 529
               R T+D + V  +  E   +P  RTP
Sbjct: 493 VCSERTTADRHSVIQNGKENSTIPDQRTP 521


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  222 bits (566), Expect = 8e-58
 Identities = 131/349 (37%), Positives = 205/349 (58%), Gaps = 21/349 (6%)

Query: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG +VAIK+IDK +    +   + L R
Sbjct: 48  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL--QKLFR 102

Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
           E +I +++ HPNI +L +++ETE + YL+ME   GG +   +    R++E EAR   RQ+
Sbjct: 103 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 162

Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN   + G  D F   CGSP YA
Sbjct: 163 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF---CGSPPYA 219

Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 276

Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
           ST   + L+  L  +P+KR  ++Q + +RW+N  +          P      D+S    +
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPEL----DISDQKRI 332

Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDS 398
            +   +GY   ++  ++   +   I A Y LL +K     S + D  DS
Sbjct: 333 DIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRK-----SSELDASDS 376


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  222 bits (566), Expect = 8e-58
 Identities = 131/349 (37%), Positives = 205/349 (58%), Gaps = 21/349 (6%)

Query: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG +VAIK+IDK +    +   + L R
Sbjct: 48  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL--QKLFR 102

Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
           E +I +++ HPNI +L +++ETE + YL+ME   GG +   +    R++E EAR   RQ+
Sbjct: 103 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 162

Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN   + G  D F   CGSP YA
Sbjct: 163 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF---CGSPPYA 219

Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 276

Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
           ST   + L+  L  +P+KR  ++Q + +RW+N  +          P      D+S    +
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPEL----DISDQKRI 332

Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDS 398
            +   +GY   ++  ++   +   I A Y LL +K     S + D  DS
Sbjct: 333 DIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRK-----SSELDASDS 376


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  222 bits (566), Expect = 8e-58
 Identities = 131/349 (37%), Positives = 205/349 (58%), Gaps = 21/349 (6%)

Query: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG +VAIK+IDK +    +   + L R
Sbjct: 48  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL--QKLFR 102

Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
           E +I +++ HPNI +L +++ETE + YL+ME   GG +   +    R++E EAR   RQ+
Sbjct: 103 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 162

Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN   + G  D F   CGSP YA
Sbjct: 163 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF---CGSPPYA 219

Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 276

Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
           ST   + L+  L  +P+KR  ++Q + +RW+N  +          P      D+S    +
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPEL----DISDQKRI 332

Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDS 398
            +   +GY   ++  ++   +   I A Y LL +K     S + D  DS
Sbjct: 333 DIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRK-----SSELDASDS 376


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score =  221 bits (562), Expect = 2e-57
 Identities = 141/421 (33%), Positives = 230/421 (54%), Gaps = 33/421 (7%)

Query: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG++VA+K+IDK +    +   + L R
Sbjct: 45  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 99

Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
           E +I +++ HPNI +L +++ETE + YLVME   GG +   +    R++E EAR   RQ+
Sbjct: 100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159

Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN      + +   T CGSP YA
Sbjct: 160 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 216

Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 273

Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
           ST   + L+  L  +P KR  ++Q + +RW+N  +      +   P    L D       
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 329

Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTR-LYQI 408
            +   +GY   ++ ++++  R   ++A Y LL  K    L G     D++  K R    +
Sbjct: 330 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSE-LEG-----DTITLKPRPSADL 383

Query: 409 EKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFL--HRPFSKKLDKNLPSHKQ 466
               AP  S++             +   K+ +  ++ G  +     +SKK   N   +K+
Sbjct: 384 TNSSAPSPSHKVQRSV--------SANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKR 435

Query: 467 P 467
           P
Sbjct: 436 P 436


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score =  221 bits (562), Expect = 2e-57
 Identities = 141/421 (33%), Positives = 230/421 (54%), Gaps = 33/421 (7%)

Query: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG++VA+K+IDK +    +   + L R
Sbjct: 45  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 99

Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
           E +I +++ HPNI +L +++ETE + YLVME   GG +   +    R++E EAR   RQ+
Sbjct: 100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159

Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN      + +   T CGSP YA
Sbjct: 160 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 216

Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 273

Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
           ST   + L+  L  +P KR  ++Q + +RW+N  +      +   P    L D       
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 329

Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTR-LYQI 408
            +   +GY   ++ ++++  R   ++A Y LL  K    L G     D++  K R    +
Sbjct: 330 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSE-LEG-----DTITLKPRPSADL 383

Query: 409 EKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFL--HRPFSKKLDKNLPSHKQ 466
               AP  S++             +   K+ +  ++ G  +     +SKK   N   +K+
Sbjct: 384 TNSSAPSPSHKVQRSV--------SANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKR 435

Query: 467 P 467
           P
Sbjct: 436 P 436


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score =  220 bits (561), Expect = 3e-57
 Identities = 125/335 (37%), Positives = 200/335 (59%), Gaps = 16/335 (4%)

Query: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG++VA+K+IDK +    +   + L R
Sbjct: 45  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 99

Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
           E +I +++ HPNI +L +++ETE + YLVME   GG +   +    R++E EAR   RQ+
Sbjct: 100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159

Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN      + +   T CGSP YA
Sbjct: 160 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 216

Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 273

Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
           ST   + L+  L  +P KR  ++Q + +RW+N  +      +   P    L D       
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 329

Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKK 384
            +   +GY   ++ ++++  R   ++A Y LL  K
Sbjct: 330 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYK 364


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  203 bits (517), Expect = 4e-52
 Identities = 123/344 (35%), Positives = 201/344 (58%), Gaps = 22/344 (6%)

Query: 57  RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
           ++G+Y++G   LG G+F KV+ G H LTG KVA+K++++++ +    V K ++RE Q  +
Sbjct: 12  KIGHYVLGDT-LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK-IKREIQNLK 69

Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
           + RHP+I +L  ++ T   +++VME   GG L   I +  R+EE EARR  +Q++SAV++
Sbjct: 70  LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129

Query: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
            HR  VVHRDLK EN+LLD   N K+ DFGLSN   ++   +   T CGSP YAAPE+++
Sbjct: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVIS 186

Query: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295
            + Y GP++D+WS GV +YA+L GTLPF  E   +  L++K +   +  +P  L+    +
Sbjct: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDE--HVPTLFKK-IRGGVFYIPEYLNRSVAT 243

Query: 296 FLRSLLEPDPVKRPNIQQALANRWLNENYTGKV-PCNVTYPNRISLEDLSPSVVLHMTEK 354
            L  +L+ DP+KR  I+    + W  ++    + P + +Y   +    +    V  + EK
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANV----IDDEAVKEVCEK 299

Query: 355 LGYKNSDVINTVLSNRACHILAIYF--------LLNKKLERYLS 390
                S+V+N++ S      LA+ +        ++N+  E YL+
Sbjct: 300 FECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLA 343


>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 1 [Homo sapiens]
          Length = 559

 Score =  201 bits (511), Expect = 2e-51
 Identities = 109/268 (40%), Positives = 171/268 (63%), Gaps = 9/268 (3%)

Query: 57  RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
           ++G+Y++G   LG G+F KV+ G H LTG KVA+K++++++ +    V K +RRE Q  +
Sbjct: 23  KIGHYILGDT-LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK-IRREIQNLK 80

Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
           + RHP+I +L  ++ T +  ++VME   GG L   I +  RL+E E+RR  +Q++S V++
Sbjct: 81  LFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 140

Query: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
            HR  VVHRDLK EN+LLD   N K+ DFGLSN   ++   +   T CGSP YAAPE+++
Sbjct: 141 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVIS 197

Query: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295
            + Y GP++D+WS GV +YA+L GTLPF  +   +  L++K+ D  +   P  L+   IS
Sbjct: 198 GRLYAGPEVDIWSSGVILYALLCGTLPF--DDDHVPTLFKKICD-GIFYTPQYLNPSVIS 254

Query: 296 FLRSLLEPDPVKRPNIQQALANRWLNEN 323
            L+ +L+ DP+KR  I+    + W  ++
Sbjct: 255 LLKHMLQVDPMKRATIKDIREHEWFKQD 282


>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
          Length = 1263

 Score =  199 bits (507), Expect = 6e-51
 Identities = 125/341 (36%), Positives = 188/341 (55%), Gaps = 22/341 (6%)

Query: 57  RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
           R+G Y I  R +G+G+FA V+   H++T  KVAIK+IDK +  ++    K + RE QI +
Sbjct: 4   RIGYYEI-DRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENL--KKIFREVQIMK 60

Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
           M+ HP+I +L  ++ETE   YLV E   GG +   +    R+ E EARR  +Q+++AV  
Sbjct: 61  MLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYF 120

Query: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
            H   +VHRDLK ENLLLD + NIK+ DFG SN   +        T CGSP YAAPEL  
Sbjct: 121 CHCRNIVHRDLKAENLLLDANLNIKIADFGFSN---LFTPGQLLKTWCGSPPYAAPELFE 177

Query: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPF---TVEPFSLRALYQKMVDKEMNPLPTQLSTG 292
            K+Y GPK+D+WS+GV +Y ++ G LPF   T++    R L  K        +P  +ST 
Sbjct: 178 GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKF------RIPFFMSTE 231

Query: 293 AISFLRSLLEPDPVKRPNIQQALANRWL-----NENYTGKVPCNVTYPNRISLEDLSPSV 347
               +R +L  DP KR +++Q   ++W+     + N+   +           ++ L+  V
Sbjct: 232 CEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDV 291

Query: 348 VLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERY 388
           +L M E +G      + ++ S+   H  AIY LL  + +R+
Sbjct: 292 LLAM-EDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRH 331


>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
          Length = 651

 Score =  197 bits (500), Expect = 4e-50
 Identities = 131/368 (35%), Positives = 196/368 (53%), Gaps = 26/368 (7%)

Query: 68  LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
           +G G FAKV+   H+LTGE VAIK++DK     D      ++ E +  + +RH +I QL 
Sbjct: 17  IGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDL---PRIKTEIEALKNLRHQHICQLY 73

Query: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187
            +LET N  ++V+E CPGG L   I  + RL E E R   RQ++SAV ++H  G  HRDL
Sbjct: 74  HVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDL 133

Query: 188 KIENLLLDEDNNIKLIDFGLSNCAGILGYSD-PFSTQCGSPAYAAPELLARKKY-GPKID 245
           K ENLL DE + +KLIDFGL  CA   G  D    T CGS AYAAPEL+  K Y G + D
Sbjct: 134 KPENLLFDEYHKLKLIDFGL--CAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEAD 191

Query: 246 VWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDP 305
           VWS+G+ +Y ++ G LPF  +  ++ ALY+K++  + + +P  LS  +I  L+ +L+ DP
Sbjct: 192 VWSMGILLYVLMCGFLPF--DDDNVMALYKKIMRGKYD-VPKWLSPSSILLLQQMLQVDP 248

Query: 306 VKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINT 365
            KR +++  L + W+ ++Y   V      P     +D    + +H        N   +  
Sbjct: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHR-----NNRQTMED 303

Query: 366 VLSN-RACHILAIYFLLNKK----------LERYLSGKSDIQDSLCYKTRLYQIEKYRAP 414
           ++S  +  H+ A Y LL  K          L  +  G++        K+  + +E   A 
Sbjct: 304 LISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTAS 363

Query: 415 KESYEASL 422
            ++Y A L
Sbjct: 364 DKNYVAGL 371


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  196 bits (499), Expect = 5e-50
 Identities = 127/341 (37%), Positives = 190/341 (55%), Gaps = 21/341 (6%)

Query: 57  RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
           RVG Y I    LG+G+FA V+ G H +T  +VAIK+IDK +   D    + + RE QI +
Sbjct: 16  RVGFYDIEGT-LGKGNFAVVKLGRHRITKTEVAIKIIDKSQL--DAVNLEKIYREVQIMK 72

Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
           M+ HP+I +L  ++ET++  YLV E    G +   +    RL ESEARR   Q++SAV++
Sbjct: 73  MLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDY 132

Query: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
            H   +VHRDLK ENLLLD + NIK+ DFG  N        +  +T CGSP YAAPE+  
Sbjct: 133 CHGRKIVHRDLKAENLLLDNNMNIKIADFGFGN---FFKSGELLATWCGSPPYAAPEVFE 189

Query: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295
            ++Y GP++D+WS+GV +Y ++ G LPF  +  +L  L Q++++     +P  +S     
Sbjct: 190 GQQYEGPQLDIWSMGVVLYVLVCGALPF--DGPTLPILRQRVLEGRFR-IPYFMSEDCEH 246

Query: 296 FLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSV------VL 349
            +R +L  DP KR  I Q   ++W+      + P  V YP     ++  PS+      VL
Sbjct: 247 LIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRP--VLYPQE---QENEPSIGEFNEQVL 301

Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLS 390
            +   LG      I ++ +    H  AIYFLL ++L+ + S
Sbjct: 302 RLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRS 342


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  196 bits (497), Expect = 8e-50
 Identities = 120/335 (35%), Positives = 187/335 (55%), Gaps = 12/335 (3%)

Query: 57  RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
           RVG Y I  R LG+G+FA V+   H +T  +VAIK+IDK R   D+   + + RE Q+ +
Sbjct: 23  RVGFYDI-ERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL--DSSNLEKIYREVQLMK 79

Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
           ++ HP+I +L  ++ET++  Y+V E    G +   +     L E+EAR+   Q++SAVE+
Sbjct: 80  LLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEY 139

Query: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
            H   +VHRDLK ENLLLD + +IKL DFG  N        +P ST CGSP YAAPE+  
Sbjct: 140 CHDHHIVHRDLKTENLLLDGNMDIKLADFGFGN---FYKSGEPLSTWCGSPPYAAPEVFE 196

Query: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295
            K+Y GP++D+WS+GV +Y ++ G+LPF  +  +L  L Q++++     +P  +S    S
Sbjct: 197 GKEYEGPQLDIWSLGVVLYVLVCGSLPF--DGPNLPTLRQRVLEGRFR-IPFFMSQDCES 253

Query: 296 FLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLS--PSVVLHMTE 353
            +R +L  DP +R  I Q   +RW+        P    +       +L       L + +
Sbjct: 254 LIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQ 313

Query: 354 KLGYKNSDVINTVLSNRACHILAIYFLLNKKLERY 388
            LG      + ++ ++   H  AIY+LL ++L+ Y
Sbjct: 314 TLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEY 348


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  193 bits (491), Expect = 4e-49
 Identities = 175/600 (29%), Positives = 268/600 (44%), Gaps = 88/600 (14%)

Query: 53  QHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREG 112
           QH + VG Y +  + LG+G    V+ G+H +TG+KVAIK++++++  +   V   + RE 
Sbjct: 26  QHAQYVGPYRL-EKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSES--VLMKVEREI 82

Query: 113 QIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLIS 172
            I ++I HP++ +L D+ E +   YLV+E   GG L   + +K RL   EAR++ RQ++S
Sbjct: 83  AILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVS 142

Query: 173 AVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAP 232
           A++  H   + HRDLK ENLLLDE NNI++ DFG+   A +        T CGSP YA P
Sbjct: 143 ALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGM---ASLQVGDSLLETSCGSPHYACP 199

Query: 233 ELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLST 291
           E++  +KY G + D+WS GV ++A+L G LPF  +  +LR L +K V + +  +P  +  
Sbjct: 200 EVIKGEKYDGRRADMWSCGVILFALLVGALPF--DDDNLRQLLEK-VKRGVFHMPHFIPP 256

Query: 292 GAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHM 351
              S LR ++E +P KR +++Q   + W         PC    P R         V +  
Sbjct: 257 DCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGR--------RVAMRS 308

Query: 352 TEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKY 411
               G  + DV+ + +++  C      F   ++L R L  + + Q+ + Y   L + E+Y
Sbjct: 309 LPSNGELDPDVLES-MASLGC------FRDRERLHRELRSEEENQEKMIYYLLLDRKERY 361

Query: 412 RAPKESYEASLDTWTRDLEFHAVQDKKPKEQ----EKRGDFLHRPFSKKLDKNLPSHKQP 467
            + ++                  QD  P+       KR D    P   +  K  P  K  
Sbjct: 362 PSCED------------------QDLPPRNDVDPPRKRVD---SPMLSRHGKRRPERKSM 400

Query: 468 SGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPR 527
               +T      + +  R+A + +   + S       R  S ++   SSS    P+  PR
Sbjct: 401 EVLSITDAGGGGSPVPTRRALEMAQHSQRS-------RSVSGASTGLSSS----PLSSPR 449

Query: 528 TPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFES-VDRDDHVEVLSPSHHYRILNSP 586
           +P     PE   PG G             D  R   S   +   +    P         P
Sbjct: 450 SPVFSFSPE---PGAG-------------DEARGGGSPTSKTQTLPSRGPRGGGAGEQPP 493

Query: 587 VSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNG 646
              AR      T  PG P    S   TPLH  L    H  + SP    G   PPP P  G
Sbjct: 494 PPSAR-----STPLPGPPGSPRSSGGTPLHSPL----HTPRASPTGTPG-TTPPPSPGGG 543


>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 2 [Homo sapiens]
          Length = 574

 Score =  192 bits (487), Expect = 1e-48
 Identities = 109/283 (38%), Positives = 171/283 (60%), Gaps = 24/283 (8%)

Query: 57  RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
           ++G+Y++G   LG G+F KV+ G H LTG KVA+K++++++ +    V K +RRE Q  +
Sbjct: 23  KIGHYILGDT-LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK-IRREIQNLK 80

Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEK---------------KRLEES 161
           + RHP+I +L  ++ T +  ++VME   GG L   I +                K L+E 
Sbjct: 81  LFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEK 140

Query: 162 EARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFS 221
           E+RR  +Q++S V++ HR  VVHRDLK EN+LLD   N K+ DFGLSN   ++   +   
Sbjct: 141 ESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLR 197

Query: 222 TQCGSPAYAAPELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDK 280
           T CGSP YAAPE+++ + Y GP++D+WS GV +YA+L GTLPF  +   +  L++K+ D 
Sbjct: 198 TSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF--DDDHVPTLFKKICD- 254

Query: 281 EMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNEN 323
            +   P  L+   IS L+ +L+ DP+KR  I+    + W  ++
Sbjct: 255 GIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD 297


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score =  191 bits (485), Expect = 2e-48
 Identities = 125/349 (35%), Positives = 195/349 (55%), Gaps = 16/349 (4%)

Query: 53  QHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREG 112
           QH + VG Y +  + LG+G    V+ G+H +T +KVAIK++++++  +   V   + RE 
Sbjct: 11  QHAQYVGPYRL-EKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSES--VLMKVEREI 67

Query: 113 QIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLIS 172
            I ++I HP++ +L D+ E +   YLV+E   GG L   + +K RL   EAR++ RQ+IS
Sbjct: 68  AILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIIS 127

Query: 173 AVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAP 232
           A++  H   + HRDLK ENLLLDE NNI++ DFG+   A +        T CGSP YA P
Sbjct: 128 ALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGM---ASLQVGDSLLETSCGSPHYACP 184

Query: 233 ELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLST 291
           E++  +KY G K DVWS GV ++A+L G LPF  +  +LR L +K V + +  +P  +  
Sbjct: 185 EVIRGEKYDGRKADVWSCGVILFALLVGALPF--DDDNLRQLLEK-VKRGVFHMPHFIPP 241

Query: 292 GAISFLRSLLEPDPVKRPNIQQALANRWL----NENYTGK-VPCNVTYPNRISLEDLSPS 346
              S LR ++E D  +R  ++    + W     NE    + +P  V   +  SLED+ P 
Sbjct: 242 DCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPD 301

Query: 347 VVLHMTEKLGYKN-SDVINTVLSNRACHILAIYFLLNKKLERYLSGKSD 394
           V+  M     +++ + ++  +LS        IYFLL  + ERY S + +
Sbjct: 302 VLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDE 350


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  177 bits (450), Expect = 2e-44
 Identities = 116/317 (36%), Positives = 177/317 (55%), Gaps = 19/317 (5%)

Query: 16  PGGGGGAEDAARPAAACEGSFL-PAWVSGVPRERLRDFQHHKRVGNYLIGSRK-LGEGSF 73
           P  G GA  + R A A   + L P    GV R       HHK    +    ++ LG+G++
Sbjct: 13  PDLGLGAPGSPREAVAGATAALEPRKPHGVKRH------HHKHNLKHRYELQETLGKGTY 66

Query: 74  AKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETE 133
            KV+      +G  VAIK I K + K +  +  ++RRE +I   + HP+I  + ++ E +
Sbjct: 67  GKVKRATERFSGRVVAIKSIRKDKIKDEQDMV-HIRREIEIMSSLNHPHIISIYEVFENK 125

Query: 134 NSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLL 193
           +   ++ME    G L   I E++RL E E R + RQ++SAV + H+ GVVHRDLK+EN+L
Sbjct: 126 DKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENIL 185

Query: 194 LDEDNNIKLIDFGLSNCAGILGYSDPF-STQCGSPAYAAPELLARKKY-GPKIDVWSIGV 251
           LD++ NIK+ DFGLSN    L   D F  T CGSP YA+PE++  + Y GP++D W++GV
Sbjct: 186 LDDNCNIKIADFGLSN----LYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGV 241

Query: 252 NMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNI 311
            +Y ++ GT+PF  + F  + L +++   E    PTQ S  A   +R +L  +P +R  I
Sbjct: 242 LLYTLVYGTMPF--DGFDHKNLIRQISSGEYRE-PTQPS-DARGLIRWMLMVNPDRRATI 297

Query: 312 QQALANRWLNENYTGKV 328
           +    + W+N  Y   V
Sbjct: 298 EDIANHWWVNWGYKSSV 314


>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
          Length = 436

 Score =  176 bits (445), Expect = 9e-44
 Identities = 107/314 (34%), Positives = 169/314 (53%), Gaps = 22/314 (7%)

Query: 49  LRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNL 108
           +R+    KR+G Y I   ++G G+F++V+ G+H LT EKVAIK++DK   K D    + L
Sbjct: 62  VREITLGKRIGFYRIRG-EIGSGNFSQVKLGIHSLTKEKVAIKILDK--TKLDQKTQRLL 118

Query: 109 RREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIR 168
            RE    + + HPNI +L +++ET +  +LVME   GG L  KI  + +L E E++    
Sbjct: 119 SREISSMEKLHHPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFS 178

Query: 169 QLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPA 228
           Q++SAV+H+H   ++HRDLK EN+    +  +K+ DFG S    +    +  +T CGSP 
Sbjct: 179 QIVSAVKHMHENQIIHRDLKAENVFYTSNTCVKVGDFGFST---VSKKGEMLNTFCGSPP 235

Query: 229 YAAPELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPT 287
           YAAPEL   + Y G  +D+W++GV +Y M+TGT+PF  E     A  +K + +    +P 
Sbjct: 236 YAAPELFRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETV---AKLKKSILEGTYSVPP 292

Query: 288 QLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSV 347
            +S      +R +L+  P +R  I   + + W+           V YP  +    L P  
Sbjct: 293 HVSEPCHRLIRGVLQQIPTERYGIDCIMNDEWMQ---------GVPYPTPLEPFQLDPK- 342

Query: 348 VLHMTEKLGYKNSD 361
             H++E    K  +
Sbjct: 343 --HLSETSTLKEEE 354


>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
           [Homo sapiens]
          Length = 357

 Score =  172 bits (437), Expect = 7e-43
 Identities = 107/259 (41%), Positives = 147/259 (56%), Gaps = 14/259 (5%)

Query: 68  LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
           LG G+F++V       TG+  A+K I KK  K       ++  E  + + I+H NI  L 
Sbjct: 29  LGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE---SSIENEIAVLRKIKHENIVALE 85

Query: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187
           DI E+ N  YLVM+L  GG L  +I EK    E +A   IRQ++ AV +LHR G+VHRDL
Sbjct: 86  DIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDL 145

Query: 188 KIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKI 244
           K ENLL    DE++ I + DFGLS    + G  D  ST CG+P Y APE+LA+K Y   +
Sbjct: 146 KPENLLYYSQDEESKIMISDFGLSK---MEGKGDVMSTACGTPGYVAPEVLAQKPYSKAV 202

Query: 245 DVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEM---NPLPTQLSTGAISFLRSLL 301
           D WSIGV  Y +L G  PF  E  S   L+++++  E    +P    +S  A  F+R+L+
Sbjct: 203 DCWSIGVIAYILLCGYPPFYDENDS--KLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260

Query: 302 EPDPVKRPNIQQALANRWL 320
           E DP KR   +QA  + W+
Sbjct: 261 EKDPNKRYTCEQAARHPWI 279


>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
           2 [Homo sapiens]
          Length = 385

 Score =  172 bits (437), Expect = 7e-43
 Identities = 107/259 (41%), Positives = 147/259 (56%), Gaps = 14/259 (5%)

Query: 68  LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
           LG G+F++V       TG+  A+K I KK  K       ++  E  + + I+H NI  L 
Sbjct: 29  LGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE---SSIENEIAVLRKIKHENIVALE 85

Query: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187
           DI E+ N  YLVM+L  GG L  +I EK    E +A   IRQ++ AV +LHR G+VHRDL
Sbjct: 86  DIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDL 145

Query: 188 KIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKI 244
           K ENLL    DE++ I + DFGLS    + G  D  ST CG+P Y APE+LA+K Y   +
Sbjct: 146 KPENLLYYSQDEESKIMISDFGLSK---MEGKGDVMSTACGTPGYVAPEVLAQKPYSKAV 202

Query: 245 DVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEM---NPLPTQLSTGAISFLRSLL 301
           D WSIGV  Y +L G  PF  E  S   L+++++  E    +P    +S  A  F+R+L+
Sbjct: 203 DCWSIGVIAYILLCGYPPFYDENDS--KLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260

Query: 302 EPDPVKRPNIQQALANRWL 320
           E DP KR   +QA  + W+
Sbjct: 261 EKDPNKRYTCEQAARHPWI 279


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  169 bits (428), Expect = 8e-42
 Identities = 113/331 (34%), Positives = 181/331 (54%), Gaps = 21/331 (6%)

Query: 66  RKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQ 125
           + LG G FA V+   HV TGEKVA+KVIDK   K DT  T +L +E +  ++++HPNI +
Sbjct: 20  KTLGRGHFAVVKLARHVFTGEKVAVKVIDK--TKLDTLATGHLFQEVRCMKLVQHPNIVR 77

Query: 126 LLDILETENSYYLVMELCPGGNLMHKIYE-KKRLEESEARRYIRQLISAVEHLHRAGVVH 184
           L ++++T+   YL++EL  GG++   I + ++ L E  A++Y  Q++ A+ + H+  VVH
Sbjct: 78  LYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVH 137

Query: 185 RDLKIENLLLDEDNN-IKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GP 242
           RDLK EN++  E    +KL DFG SN           +T CGS AY+APE+L   +Y  P
Sbjct: 138 RDLKPENVVFFEKQGLVKLTDFGFSN---KFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 194

Query: 243 KIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLE 302
            +D+WS+GV ++ ++ G  PF  E      L   M  K    +P+ +S      +  +L+
Sbjct: 195 AVDIWSLGVILFMLVCGQPPFQ-EANDSETLTMIMDCK--YTVPSHVSKECKDLITRMLQ 251

Query: 303 PDPVKRPNIQQALANRWLNENYTGKVPCNVTYPN--RISLEDLSP----SVVLHMTEKLG 356
            DP +R ++++   + WL     G  P   T  N   +S ++LS     S++  M     
Sbjct: 252 RDPKRRASLEEIENHPWLQ----GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDI 307

Query: 357 YKNSDVINTVLSNRACHILAIYFLLNKKLER 387
                ++  + +NR  HI A YFLL +++ R
Sbjct: 308 ADRDAIVEALETNRYNHITATYFLLAERILR 338


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  169 bits (428), Expect = 8e-42
 Identities = 113/331 (34%), Positives = 181/331 (54%), Gaps = 21/331 (6%)

Query: 66  RKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQ 125
           + LG G FA V+   HV TGEKVA+KVIDK   K DT  T +L +E +  ++++HPNI +
Sbjct: 20  KTLGRGHFAVVKLARHVFTGEKVAVKVIDK--TKLDTLATGHLFQEVRCMKLVQHPNIVR 77

Query: 126 LLDILETENSYYLVMELCPGGNLMHKIYE-KKRLEESEARRYIRQLISAVEHLHRAGVVH 184
           L ++++T+   YL++EL  GG++   I + ++ L E  A++Y  Q++ A+ + H+  VVH
Sbjct: 78  LYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVH 137

Query: 185 RDLKIENLLLDEDNN-IKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GP 242
           RDLK EN++  E    +KL DFG SN           +T CGS AY+APE+L   +Y  P
Sbjct: 138 RDLKPENVVFFEKQGLVKLTDFGFSN---KFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 194

Query: 243 KIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLE 302
            +D+WS+GV ++ ++ G  PF  E      L   M  K    +P+ +S      +  +L+
Sbjct: 195 AVDIWSLGVILFMLVCGQPPFQ-EANDSETLTMIMDCK--YTVPSHVSKECKDLITRMLQ 251

Query: 303 PDPVKRPNIQQALANRWLNENYTGKVPCNVTYPN--RISLEDLSP----SVVLHMTEKLG 356
            DP +R ++++   + WL     G  P   T  N   +S ++LS     S++  M     
Sbjct: 252 RDPKRRASLEEIENHPWLQ----GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDI 307

Query: 357 YKNSDVINTVLSNRACHILAIYFLLNKKLER 387
                ++  + +NR  HI A YFLL +++ R
Sbjct: 308 ADRDAIVEALETNRYNHITATYFLLAERILR 338


>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
           sapiens]
          Length = 476

 Score =  166 bits (420), Expect = 7e-41
 Identities = 104/262 (39%), Positives = 152/262 (58%), Gaps = 16/262 (6%)

Query: 68  LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
           LG G+F++V      LTG+  A+K I K  A +D+    +L  E  + + I+H NI  L 
Sbjct: 29  LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDS----SLENEIAVLKKIKHENIVTLE 84

Query: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187
           DI E+   YYLVM+L  GG L  +I E+    E +A   I+Q++SAV++LH  G+VHRDL
Sbjct: 85  DIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDL 144

Query: 188 KIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKI 244
           K ENLL    +E++ I + DFGLS     +  +   ST CG+P Y APE+LA+K Y   +
Sbjct: 145 KPENLLYLTPEENSKIMITDFGLSK----MEQNGIMSTACGTPGYVAPEVLAQKPYSKAV 200

Query: 245 DVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVD---KEMNPLPTQLSTGAISFLRSLL 301
           D WSIGV  Y +L G  PF  E  S   L++K+ +   +  +P    +S  A  F+  LL
Sbjct: 201 DCWSIGVITYILLCGYPPFYEETES--KLFEKIKEGYYEFESPFWDDISESAKDFICHLL 258

Query: 302 EPDPVKRPNIQQALANRWLNEN 323
           E DP +R   ++AL++ W++ N
Sbjct: 259 EKDPNERYTCEKALSHPWIDGN 280


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score =  166 bits (419), Expect = 9e-41
 Identities = 98/263 (37%), Positives = 155/263 (58%), Gaps = 12/263 (4%)

Query: 68  LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
           LG+G++ KV++     +G  VAIK I K + K D     ++RRE +I   + HP+I  + 
Sbjct: 59  LGKGTYGKVKKARES-SGRLVAIKSIRKDKIK-DEQDLMHIRREIEIMSSLNHPHIIAIH 116

Query: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187
           ++ E  +   +VME    G+L   I E+++L E EAR + RQ++SAV + H+  VVHRDL
Sbjct: 117 EVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDL 176

Query: 188 KIENLLLDEDNNIKLIDFGLSNCAGILGYSDPF-STQCGSPAYAAPELLARKKY-GPKID 245
           K+EN+LLD + NIK+ DFGLSN    L +   F  T CGSP YA+PE++  K Y GP++D
Sbjct: 177 KLENILLDANGNIKIADFGLSN----LYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVD 232

Query: 246 VWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDP 305
            WS+GV +Y ++ GT+PF  +    + L +++ +      P    + A   +R LL  +P
Sbjct: 233 SWSLGVLLYILVHGTMPF--DGHDHKILVKQISNGAYREPPK--PSDACGLIRWLLMVNP 288

Query: 306 VKRPNIQQALANRWLNENYTGKV 328
            +R  ++   ++ W+N  Y  +V
Sbjct: 289 TRRATLEDVASHWWVNWGYATRV 311


>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
          Length = 367

 Score =  164 bits (416), Expect = 2e-40
 Identities = 108/279 (38%), Positives = 162/279 (58%), Gaps = 16/279 (5%)

Query: 56  KRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQ 115
           KR G YL+G   LGEGS+AKV+          VAIK+ID+K+A  D ++ K L RE +I 
Sbjct: 8   KRRG-YLLGIN-LGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPAD-FLEKFLPREIEIL 64

Query: 116 QMIRHPNITQLLDILETENS-YYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAV 174
            M+ H +I +  +I ET +   Y+VMEL   G+L+  I  +  L E EAR+   QL  A+
Sbjct: 65  AMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAI 124

Query: 175 EHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLS-----NCAGILGYSDPFSTQCGSPAY 229
           ++ H   VVHRDLK +NLLLD+D NIKL DF  S     + +G +  S  F   CGSPAY
Sbjct: 125 KYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTF---CGSPAY 181

Query: 230 AAPELLARKKYGPKI-DVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMN-PLPT 287
           AAPE+L    Y PK+ D+WS+GV +Y M+ G++P+  +  +++ + +   +  +N P   
Sbjct: 182 AAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPY--DDSNIKKMLRIQKEHRVNFPRSK 239

Query: 288 QLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTG 326
            L+      +  +L+PD  +R +I + L++ W+     G
Sbjct: 240 HLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARG 278


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,488,793
Number of Sequences: 37866
Number of extensions: 1709439
Number of successful extensions: 11176
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 722
Number of HSP's successfully gapped in prelim test: 221
Number of HSP's that attempted gapping in prelim test: 8200
Number of HSP's gapped (non-prelim): 1657
length of query: 714
length of database: 18,247,518
effective HSP length: 109
effective length of query: 605
effective length of database: 14,120,124
effective search space: 8542675020
effective search space used: 8542675020
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.