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Search of human proteins with 7657106
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
sapiens]
(440 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s... 880 0.0
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p... 325 7e-89
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre... 324 1e-88
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is... 314 1e-85
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso... 314 1e-85
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso... 309 4e-84
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is... 299 3e-81
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom... 296 3e-80
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec... 288 7e-78
gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom... 287 1e-77
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens] 276 3e-74
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens] 275 5e-74
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens] 274 1e-73
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens] 274 1e-73
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens] 274 1e-73
gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo... 273 2e-73
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo... 270 2e-72
gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens] 260 2e-69
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 254 1e-67
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 254 1e-67
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso... 253 3e-67
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur... 251 1e-66
gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor... 243 3e-64
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs... 242 6e-64
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr... 239 3e-63
gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform... 238 8e-63
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ... 236 3e-62
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s... 235 5e-62
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs... 235 5e-62
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso... 233 2e-61
>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
sapiens]
Length = 440
Score = 880 bits (2274), Expect = 0.0
Identities = 440/440 (100%), Positives = 440/440 (100%)
Query: 1 MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEP 60
MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEP
Sbjct: 1 MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEP 60
Query: 61 VQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDT 120
VQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDT
Sbjct: 61 VQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDT 120
Query: 121 YIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLES 180
YIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLES
Sbjct: 121 YIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLES 180
Query: 181 WGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRR 240
WGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRR
Sbjct: 181 WGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRR 240
Query: 241 NVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTN 300
NVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTN
Sbjct: 241 NVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTN 300
Query: 301 CFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSIS 360
CFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSIS
Sbjct: 301 CFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSIS 360
Query: 361 SFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKL 420
SFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKL
Sbjct: 361 SFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKL 420
Query: 421 LFPLIFMLANVFYWAYYMYF 440
LFPLIFMLANVFYWAYYMYF
Sbjct: 421 LFPLIFMLANVFYWAYYMYF 440
>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
precursor [Homo sapiens]
Length = 474
Score = 325 bits (832), Expect = 7e-89
Identities = 179/436 (41%), Positives = 259/436 (59%), Gaps = 41/436 (9%)
Query: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101
+ L GY+ LRP+FGG PV + + +D+ASI +SE NMDYT T+Y +Q W D+RL + G
Sbjct: 42 DRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSG 101
Query: 102 NK-SFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
+ TLD R+ + LWVPDTY + KKSF+H VTV NR+IRL +GTVLY LRITTT AC
Sbjct: 102 IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAAC 161
Query: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT 220
MDL +YP+D Q C L++ES+GY +D+EF W G +V G+ + L Q++I Y +
Sbjct: 162 MMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSK 221
Query: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280
+ + TG Y RL L F L+RN+ YFIL+TY+PST + +LSWVSFWI+ D+ AR +G+T
Sbjct: 222 KVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGIT 281
Query: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHY----------- 329
TVL+MTT+ R +LP ++KAID+YL CF FVF ALLEYA +Y
Sbjct: 282 TVLTMTTISTHLRETLPKIP-YVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKG 340
Query: 330 SSLQQMAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSD 389
+S Q +A ++ E+ +V + N +S+ + + + E+ + +V TM + D
Sbjct: 341 ASKQDQSANEKNKL-EMNKVQVDAHGNILLSTLEIRNETSGSEVLT-SVSDPKATMYSYD 398
Query: 390 KFKFVF------REKMGRIVDYFTIQNP--------------------SNVDHYSKLLFP 423
+ RE GR +D + + +++D +S++ FP
Sbjct: 399 SASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFP 458
Query: 424 LIFMLANVFYWAYYMY 439
+ F L NV YW YY++
Sbjct: 459 ITFSLFNVVYWLYYVH 474
>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
precursor [Homo sapiens]
Length = 452
Score = 324 bits (830), Expect = 1e-88
Identities = 179/420 (42%), Positives = 263/420 (62%), Gaps = 13/420 (3%)
Query: 30 VGRSDKLS-LPGFENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYL 88
VG + ++S LP + L AGY + RP GG PV +AL L++ASI ISE+NM+YT T++L
Sbjct: 32 VGSNLEISWLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFL 91
Query: 89 RQRWMDQRLVFEG-NKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGT 147
Q W D RL + N++ LD+R V+ LW+PDT+IV +K ++ H+VTV N+LIRL +G
Sbjct: 92 HQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGV 151
Query: 148 VLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRL 207
+LY++RIT+TVAC+MDL+KYPMD Q C L LES+GY D+ + W + + GL+ L+L
Sbjct: 152 ILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQL 211
Query: 208 AQYTIERY-FTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWI 266
AQ+TI Y FT + + G + RL L F LRRN +I+++Y+PS LV +SWVSFWI
Sbjct: 212 AQFTITSYRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWI 271
Query: 267 SLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAV 326
S +VPAR +G+TTVL+MTTLM+ +R+SLP + IKA+DVY IC+ FVF AL+EYA
Sbjct: 272 SQAAVPARVSLGITTVLTMTTLMVSARSSLPRASA-IKALDVYFWICYVFVFAALVEYAF 330
Query: 327 AHYSSLQQMAAKDR-GTTKEVEEVSITN-IINSSISSF----KRKISFASIEISSDNV-D 379
AH+++ + K + ++ E+ + N I+ S+S+ + IS + + +
Sbjct: 331 AHFNADYRKKQKAKVKVSRPRAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGS 390
Query: 380 YSDLTMKTSDKFKFVFREK--MGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYY 437
Y + ++T + K G I + +D Y++ +FP F NV YWA Y
Sbjct: 391 YRSVGVETGETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 2 precursor [Homo sapiens]
Length = 473
Score = 314 bits (804), Expect = 1e-85
Identities = 174/432 (40%), Positives = 252/432 (58%), Gaps = 36/432 (8%)
Query: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101
+ L GY+ LRP+FGG PV + + +DIASI +SE NMDYT T+Y +Q W D+RL + G
Sbjct: 42 DKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSG 101
Query: 102 NK-SFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
+ TLD R+ + LWVPDTY + KKSF+H VTV NR+IRL +GTVLY LRITTT AC
Sbjct: 102 IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAAC 161
Query: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT 220
MDL +YP+D Q C L++ES+GY +D+EF W G+ +V G+E + L Q++I + +
Sbjct: 162 MMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSR 221
Query: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280
TG Y RL L F L+RN+ YFIL+TY+PS + +LSWVSFWI+ D+ AR +G+T
Sbjct: 222 NVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGIT 281
Query: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHY----------S 330
TVL+MTT+ R +LP ++KAID+YL CF FVF ALLEYA +Y
Sbjct: 282 TVLTMTTINTHLRETLPKIP-YVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340
Query: 331 SLQQMAAK---DRGTTKEVEEVSITNIINSSISSFKRKISF---------ASIEISSDNV 378
L + AK DR ++ + NI+ +S+ ++I + +
Sbjct: 341 KLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGI 400
Query: 379 DYSDLTMKTSDKFKFV-----------FREKMGRI-VDYFTIQNPSNVDHYSKLLFPLIF 426
Y +M +F+ R + ++ + + + + +D +S+++FP F
Sbjct: 401 QYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTF 460
Query: 427 MLANVFYWAYYM 438
L N+ YW YY+
Sbjct: 461 SLFNLVYWLYYV 472
>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 1 precursor [Homo sapiens]
Length = 473
Score = 314 bits (804), Expect = 1e-85
Identities = 174/432 (40%), Positives = 252/432 (58%), Gaps = 36/432 (8%)
Query: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101
+ L GY+ LRP+FGG PV + + +DIASI +SE NMDYT T+Y +Q W D+RL + G
Sbjct: 42 DKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSG 101
Query: 102 NK-SFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
+ TLD R+ + LWVPDTY + KKSF+H VTV NR+IRL +GTVLY LRITTT AC
Sbjct: 102 IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAAC 161
Query: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT 220
MDL +YP+D Q C L++ES+GY +D+EF W G+ +V G+E + L Q++I + +
Sbjct: 162 MMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSR 221
Query: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280
TG Y RL L F L+RN+ YFIL+TY+PS + +LSWVSFWI+ D+ AR +G+T
Sbjct: 222 NVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGIT 281
Query: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHY----------S 330
TVL+MTT+ R +LP ++KAID+YL CF FVF ALLEYA +Y
Sbjct: 282 TVLTMTTINTHLRETLPKIP-YVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340
Query: 331 SLQQMAAK---DRGTTKEVEEVSITNIINSSISSFKRKISF---------ASIEISSDNV 378
L + AK DR ++ + NI+ +S+ ++I + +
Sbjct: 341 KLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGI 400
Query: 379 DYSDLTMKTSDKFKFV-----------FREKMGRI-VDYFTIQNPSNVDHYSKLLFPLIF 426
Y +M +F+ R + ++ + + + + +D +S+++FP F
Sbjct: 401 QYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTF 460
Query: 427 MLANVFYWAYYM 438
L N+ YW YY+
Sbjct: 461 SLFNLVYWLYYV 472
>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 2 [Homo sapiens]
Length = 474
Score = 309 bits (791), Expect = 4e-84
Identities = 170/434 (39%), Positives = 251/434 (57%), Gaps = 38/434 (8%)
Query: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101
+ L GY+ LRP+FGG PV + + +DIASI +SE NMDYT T+Y +Q W D+RL +
Sbjct: 41 DRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNV 100
Query: 102 NK-SFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
+ TLD R+ + LWVPDTY + KKSF+H VTV NR+IRL +GTVLY LRITTT AC
Sbjct: 101 IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAAC 160
Query: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT 220
MDL +YP+D Q C L++ES+GY +D+EF W +++V G+ + L Q++I Y +
Sbjct: 161 MMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITK 220
Query: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280
+ TG+Y RL L F+L+RN+ YFIL+TY+PS + +LSWVSFWI+ D+ AR +G+T
Sbjct: 221 KVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGIT 280
Query: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHY-----SSLQQM 335
TVL+MTT+ R +LP ++KAID+YL CF FVF ALLEYA+ +Y +Q
Sbjct: 281 TVLTMTTINTHLRETLPKIP-YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQK 339
Query: 336 AAKDRGTTKEVEEVSI--------TNIINSSIS------------------SFKRKISFA 369
A ++ + E++ + NI+ S++ S +
Sbjct: 340 KAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDAS 399
Query: 370 SIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNP-----SNVDHYSKLLFPL 424
SI+ + ++ + ++ R I P + +D +S++ FP+
Sbjct: 400 SIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPV 459
Query: 425 IFMLANVFYWAYYM 438
+F N+ YW YY+
Sbjct: 460 VFSFFNIVYWLYYV 473
>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 1 [Homo sapiens]
Length = 512
Score = 299 bits (766), Expect = 3e-81
Identities = 148/289 (51%), Positives = 202/289 (69%), Gaps = 2/289 (0%)
Query: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101
+ L GY+ LRP+FGG PV + + +DIASI +SE NMDYT T+Y +Q W D+RL +
Sbjct: 41 DRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNV 100
Query: 102 NK-SFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
+ TLD R+ + LWVPDTY + KKSF+H VTV NR+IRL +GTVLY LRITTT AC
Sbjct: 101 IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAAC 160
Query: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT 220
MDL +YP+D Q C L++ES+GY +D+EF W +++V G+ + L Q++I Y +
Sbjct: 161 MMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITK 220
Query: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280
+ TG+Y RL L F+L+RN+ YFIL+TY+PS + +LSWVSFWI+ D+ AR +G+T
Sbjct: 221 KVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGIT 280
Query: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHY 329
TVL+MTT+ R +LP ++KAID+YL CF FVF ALLEYA+ +Y
Sbjct: 281 TVLTMTTINTHLRETLPKIP-YVKAIDMYLMGCFVFVFMALLEYALVNY 328
Score = 35.0 bits (79), Expect = 0.14
Identities = 10/25 (40%), Positives = 18/25 (72%)
Query: 414 VDHYSKLLFPLIFMLANVFYWAYYM 438
+D +S++ FP++F N+ YW YY+
Sbjct: 487 IDRWSRIFFPVVFSFFNIVYWLYYV 511
>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
sapiens]
Length = 467
Score = 296 bits (757), Expect = 3e-80
Identities = 150/395 (37%), Positives = 237/395 (60%), Gaps = 9/395 (2%)
Query: 52 LRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--NKSFTLDA 109
+RP FGG PV + + + + SI SISE+NMD+T T YLR W D+RL F NKS T D
Sbjct: 74 MRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDH 133
Query: 110 RLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPM 169
RL +WVPD + V SK+SF+H+ T+ N ++R+ +G VL +LRIT + C MD S++P+
Sbjct: 134 RLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPL 193
Query: 170 DTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRS-QQETGN 228
DTQ C L+LES+ Y+ +D+ W GN S+ EH+ L+Q+ IE + + TG
Sbjct: 194 DTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGW 253
Query: 229 YTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTL 288
Y RL + F LRR+V +F+L+TY P+ +V+LSWVSFWI +VPAR +G+TTVL+M+T+
Sbjct: 254 YNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTI 313
Query: 289 MIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSL--QQMAAKDRGTTKEV 346
+ S+P + ++KA+DVYL + FVF +++EYA +Y + ++ K G +
Sbjct: 314 ITAVSASMPQVS-YLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKISRM 372
Query: 347 EEVSITNIINSSISSFKRKISFASIEISSDNVDY---SDLTMKTSDKFKFVFREKMGRIV 403
+ + +I +S ++ D+ + ++D + R+ +G V
Sbjct: 373 YNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLGGHV 432
Query: 404 DYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYM 438
++N +D YS++LFP++++L N+FYW Y+
Sbjct: 433 GRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
precursor [Homo sapiens]
Length = 490
Score = 288 bits (737), Expect = 7e-78
Identities = 150/399 (37%), Positives = 239/399 (59%), Gaps = 15/399 (3%)
Query: 52 LRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--NKSFTLDA 109
+RP FGG + + + + + S+ SISE +MD+T T+YLR W D+RL F NKS T D
Sbjct: 93 MRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFDG 152
Query: 110 RLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPM 169
RLV+ +WVPD + V SK+SF H+ T N ++R+F +G VLY++RIT T CNMD S +P+
Sbjct: 153 RLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPL 212
Query: 170 DTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRS-QQETGN 228
D+QTC L+LES+ Y D+ W G++S++ E + L+Q+ I+++ T + TG
Sbjct: 213 DSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGW 272
Query: 229 YTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTL 288
Y RL + F LRR++ +F+L+TY P+T +V+LSWVSFWI +VPAR +G+TTVL+MTT+
Sbjct: 273 YNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTI 332
Query: 289 MIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEE 348
+ G S+P + ++KA+D+YL + F FVF ++LEYA +Y + Q K+R ++
Sbjct: 333 ITGVNASMPRVS-YVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQ-ERKERKLREKFPC 390
Query: 349 V-----SITNIINSSISSFKRK--ISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGR 401
+ S T +++ S S + + I ++ + + + K G
Sbjct: 391 MCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGL 450
Query: 402 I---VDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYY 437
+ + QN +D YS+L+FP ++ N+ YW+ +
Sbjct: 451 LKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVF 489
>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
sapiens]
Length = 479
Score = 287 bits (735), Expect = 1e-77
Identities = 151/409 (36%), Positives = 242/409 (59%), Gaps = 41/409 (10%)
Query: 52 LRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--NKSFTLDA 109
+RP FGG + + + + + S+ SISE +MD+T T+YLR W D+RL F N S T D
Sbjct: 88 MRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDG 147
Query: 110 RLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPM 169
RLV+ +WVPD + V SK+SF+H+ T N ++R+ +G VLY+LR+T T CNMD S++P+
Sbjct: 148 RLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPL 207
Query: 170 DTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRS-QQETGN 228
DTQTC L++ES+ Y +D+ W +GNDS++ E + L+Q+ I+ + T + TG
Sbjct: 208 DTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGW 267
Query: 229 YTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTL 288
Y RL + F LRR++ +F+L+TY P+T +V+LSWVSFWI +VPAR +G+TTVL+M+T+
Sbjct: 268 YNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTI 327
Query: 289 MIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEE 348
+ G S+P + +IKA+D+YL + F FVF ++LEYA +Y + Q +R K E+
Sbjct: 328 ITGVNASMPRVS-YIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQ----ERKEQKLREK 382
Query: 349 VSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTI 408
+ T+ + ++ + +YSD + D + EK R++ T+
Sbjct: 383 LPCTSGLPPPRTAML-------------DGNYSDGEVNDLDNYMPENGEKPDRMMVQLTL 429
Query: 409 QNPSN--------------------VDHYSKLLFPLIFMLANVFYWAYY 437
+ + +D YS+++FP ++L N+ YW+ +
Sbjct: 430 ASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIF 478
>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
Length = 464
Score = 276 bits (705), Expect = 3e-74
Identities = 150/405 (37%), Positives = 228/405 (56%), Gaps = 19/405 (4%)
Query: 45 TAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--N 102
T+GY+ +RPNF G PV + + I S SI+E+ MDY I+LRQ+W D RL + +
Sbjct: 54 TSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPD 113
Query: 103 KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNM 162
S LD +++ +W PD + K + HEVT N+L+R+F NG VLY++R+T T++C M
Sbjct: 114 DSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPM 173
Query: 163 DLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIE-----RYFT 217
DL +PMD QTC +QLES+GY ND+ F W + V+ E L L Q+ ++ RY T
Sbjct: 174 DLKNFPMDVQTCIMQLESFGYTMNDLIFEW-QDEAPVQVAEGLTLPQFLLKEEKDLRYCT 232
Query: 218 LVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCI 277
TG +T + ++F L R + Y++++ Y+PS +V+LSWVSFWI++D+ PAR +
Sbjct: 233 ----KHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVAL 288
Query: 278 GVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQ---- 333
G+TTVL+MTT GSR SLP + ++KAID+++ +C FVF ALLEYA ++ S Q
Sbjct: 289 GITTVLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKEL 347
Query: 334 -QMAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFK 392
+ K + T+ + + + SF + + +T K +
Sbjct: 348 LRFRRKRKNKTEAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPV 407
Query: 393 FVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYY 437
V + + F I +D S+ FPL F++ N+FYW Y
Sbjct: 408 QVMPKSPDEMRKVF-IDRAKKIDTISRACFPLAFLIFNIFYWVIY 451
>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
Length = 449
Score = 275 bits (704), Expect = 5e-74
Identities = 152/405 (37%), Positives = 227/405 (56%), Gaps = 34/405 (8%)
Query: 45 TAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--N 102
T+GY+ +RPNF G PV + + I S SI+E+ MDY I+LRQ+W D RL + +
Sbjct: 54 TSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPD 113
Query: 103 KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNM 162
S LD +++ +W PD + K + HEVT N+L+R+F NG VLY++R+T T++C M
Sbjct: 114 DSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPM 173
Query: 163 DLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIE-----RYFT 217
DL +PMD QTC +QLES+GY ND+ F W + V+ E L L Q+ ++ RY T
Sbjct: 174 DLKNFPMDVQTCIMQLESFGYTMNDLIFEW-QDEAPVQVAEGLTLPQFLLKEEKDLRYCT 232
Query: 218 LVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCI 277
TG +T + ++F L R + Y++++ Y+PS +V+LSWVSFWI++D+ PAR +
Sbjct: 233 ----KHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVAL 288
Query: 278 GVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQ---- 333
G+TTVL+MTT GSR SLP + ++KAID+++ +C FVF ALLEYA ++ S Q
Sbjct: 289 GITTVLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKEL 347
Query: 334 -QMAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFK 392
+ K + EV E + SF + + +T K +
Sbjct: 348 LRFRRKRKNKDDEVRE---------------SRFSFTAYGMGPCLQAKDGMTPKGPNHPV 392
Query: 393 FVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYY 437
V + + F I +D S+ FPL F++ N+FYW Y
Sbjct: 393 QVMPKSPDEMRKVF-IDRAKKIDTISRACFPLAFLIFNIFYWVIY 436
>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
Length = 452
Score = 274 bits (701), Expect = 1e-73
Identities = 145/398 (36%), Positives = 226/398 (56%), Gaps = 16/398 (4%)
Query: 45 TAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--N 102
T+GY+ +RPNF G PV + + I S SI+E+ MDY I+LRQ+W D RL + +
Sbjct: 55 TSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPD 114
Query: 103 KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNM 162
S LD +++ +W PD + K + H+VT N+L+R+ NG VLY++R+T T++C M
Sbjct: 115 DSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPM 174
Query: 163 DLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTL-VTR 221
DL +PMD QTC +QLES+GY ND+ F WL + V+ E L L Q+ ++ L
Sbjct: 175 DLKNFPMDVQTCTMQLESFGYTMNDLIFEWL-SDGPVQVAEGLTLPQFILKEEKELGYCT 233
Query: 222 SQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTT 281
TG +T + ++F L R + Y++++ Y+PS +V+LSWVSFWI++D+ PAR +G+TT
Sbjct: 234 KHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITT 293
Query: 282 VLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQ--QMAAKD 339
VL+MTT GSR SLP + ++KAID+++ +C FVF ALLEYA ++ S Q +
Sbjct: 294 VLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLR 352
Query: 340 RGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKM 399
R ++ +E +T + + +F+ + +K + K
Sbjct: 353 RRQKRQNKEEDVTR---------ESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKD 403
Query: 400 GRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYY 437
G + + +D S+ FPL F++ N+FYW Y
Sbjct: 404 GDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441
>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 274 bits (700), Expect = 1e-73
Identities = 144/398 (36%), Positives = 226/398 (56%), Gaps = 16/398 (4%)
Query: 45 TAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--N 102
T+GY+ +RPNF G PV + + I S S++E+ MDY I+LRQ+W D RL + +
Sbjct: 55 TSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPD 114
Query: 103 KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNM 162
S LD +++ +W PD + K + H+VT N+L+R+ NG VLY++R+T T++C M
Sbjct: 115 DSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPM 174
Query: 163 DLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTL-VTR 221
DL +PMD QTC +QLES+GY ND+ F WL + V+ E L L Q+ ++ L
Sbjct: 175 DLKNFPMDVQTCTMQLESFGYTMNDLIFEWL-SDGPVQVAEGLTLPQFILKEEKELGYCT 233
Query: 222 SQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTT 281
TG +T + ++F L R + Y++++ Y+PS +V+LSWVSFWI++D+ PAR +G+TT
Sbjct: 234 KHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITT 293
Query: 282 VLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQ--QMAAKD 339
VL+MTT GSR SLP + ++KAID+++ +C FVF ALLEYA ++ S Q +
Sbjct: 294 VLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLR 352
Query: 340 RGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKM 399
R ++ +E +T + + +F+ + +K + K
Sbjct: 353 RRQKRQNKEEDVTR---------ESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKD 403
Query: 400 GRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYY 437
G + + +D S+ FPL F++ N+FYW Y
Sbjct: 404 GDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441
>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 274 bits (700), Expect = 1e-73
Identities = 144/398 (36%), Positives = 226/398 (56%), Gaps = 16/398 (4%)
Query: 45 TAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--N 102
T+GY+ +RPNF G PV + + I S S++E+ MDY I+LRQ+W D RL + +
Sbjct: 55 TSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPD 114
Query: 103 KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNM 162
S LD +++ +W PD + K + H+VT N+L+R+ NG VLY++R+T T++C M
Sbjct: 115 DSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPM 174
Query: 163 DLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTL-VTR 221
DL +PMD QTC +QLES+GY ND+ F WL + V+ E L L Q+ ++ L
Sbjct: 175 DLKNFPMDVQTCTMQLESFGYTMNDLIFEWL-SDGPVQVAEGLTLPQFILKEEKELGYCT 233
Query: 222 SQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTT 281
TG +T + ++F L R + Y++++ Y+PS +V+LSWVSFWI++D+ PAR +G+TT
Sbjct: 234 KHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITT 293
Query: 282 VLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQ--QMAAKD 339
VL+MTT GSR SLP + ++KAID+++ +C FVF ALLEYA ++ S Q +
Sbjct: 294 VLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLR 352
Query: 340 RGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKM 399
R ++ +E +T + + +F+ + +K + K
Sbjct: 353 RRQKRQNKEEDVTR---------ESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKD 403
Query: 400 GRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYY 437
G + + +D S+ FPL F++ N+FYW Y
Sbjct: 404 GDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441
>gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo
sapiens]
Length = 449
Score = 273 bits (699), Expect = 2e-73
Identities = 152/402 (37%), Positives = 231/402 (57%), Gaps = 21/402 (5%)
Query: 45 TAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--N 102
T+GY+ +RPNF G PV ++ + I S SI+E+ MDY I+LRQ+W D RL + +
Sbjct: 49 TSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPD 108
Query: 103 KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNM 162
S LD +++ +W PD + K + HE+T N+L+R+ NG VLY++RIT T+AC M
Sbjct: 109 DSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPM 168
Query: 163 DLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIE-----RYFT 217
DL +PMD QTC +QLES+GY ND+ F W + +V+ + L L Q+ ++ RY T
Sbjct: 169 DLKNFPMDVQTCIMQLESFGYTMNDLIFEW-QEQGAVQVADGLTLPQFILKEEKDLRYCT 227
Query: 218 LVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCI 277
TG +T + +F L R + Y++++ Y+PS +V+LSW+SFWI++D+ PAR +
Sbjct: 228 ----KHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGL 283
Query: 278 GVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQ--QM 335
G+TTVL+MTT GSR SLP + ++KAID+++ +C FVF ALLEYA ++ S Q ++
Sbjct: 284 GITTVLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKEL 342
Query: 336 AAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVF 395
R E+ + N S A IS + S+ T K
Sbjct: 343 LRFRRKRRHHKEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSK--S 400
Query: 396 REKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYY 437
E+M ++ IQ +D S++ FP+ F++ N+FYW Y
Sbjct: 401 PEEMRKLF----IQRAKKIDKISRIGFPMAFLIFNMFYWIIY 438
>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 457
Score = 270 bits (690), Expect = 2e-72
Identities = 145/405 (35%), Positives = 233/405 (57%), Gaps = 19/405 (4%)
Query: 45 TAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--N 102
T+GY+ +RPNF G PV ++ + I S SI+E+ MDY I+LRQ+W D RL + +
Sbjct: 49 TSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPD 108
Query: 103 KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNM 162
S LD +++ +W PD + K + HE+T N+L+R+ NG VLY++RIT T+AC M
Sbjct: 109 DSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPM 168
Query: 163 DLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIE-----RYFT 217
DL +PMD QTC +QLES+GY ND+ F W + +V+ + L L Q+ ++ RY T
Sbjct: 169 DLKNFPMDVQTCIMQLESFGYTMNDLIFEW-QEQGAVQVADGLTLPQFILKEEKDLRYCT 227
Query: 218 LVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCI 277
TG +T + +F L R + Y++++ Y+PS +V+LSW+SFWI++D+ PAR +
Sbjct: 228 ----KHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGL 283
Query: 278 GVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAA 337
G+TTVL+MTT GSR SLP + ++KAID+++ +C FVF ALLEYA ++ S Q
Sbjct: 284 GITTVLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKEL 342
Query: 338 KDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSD-LTMKTSDKFKFV-- 394
+ + + N+ + + + +F++ + + D +++K ++
Sbjct: 343 LRFRRKRRHHKSPMLNLFQED-EAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNP 401
Query: 395 --FREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYY 437
K + IQ +D S++ FP+ F++ N+FYW Y
Sbjct: 402 PPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIY 446
>gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
Length = 417
Score = 260 bits (665), Expect = 2e-69
Identities = 127/293 (43%), Positives = 191/293 (65%), Gaps = 6/293 (2%)
Query: 45 TAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--N 102
T+GY+ +RPNF G PV + + I S SSI+++ MDY ++LRQ+W D RL + +
Sbjct: 55 TSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPD 114
Query: 103 KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNM 162
S LD +++ +W PD + K + HEVT N+L+R+F NG VLY++R+T ++C M
Sbjct: 115 DSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLM 174
Query: 163 DLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTI--ERYFTLVT 220
DL +PMD QTC +QLES+GY D+ F WL +V+ E L L Q+ + E+ T
Sbjct: 175 DLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCT 234
Query: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280
+ TG +T + ++F L R + Y++++ Y+PS +V+LSWVSFWI++D+ PAR +G+T
Sbjct: 235 K-HYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGIT 293
Query: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQ 333
TVL+MTT GSR SLP + ++KAID+++ +C FVF ALLEYA ++ S Q
Sbjct: 294 TVLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFAALLEYAAINFVSRQ 345
>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
precursor [Homo sapiens]
Length = 467
Score = 254 bits (649), Expect = 1e-67
Identities = 139/404 (34%), Positives = 221/404 (54%), Gaps = 16/404 (3%)
Query: 43 NLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGN 102
NL GY+ LRP+ G +P I + + SI ++ NM+YT I+ Q W D+RL F
Sbjct: 72 NLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNST 131
Query: 103 -KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACN 161
K L++ +V +W+PDT+ SKK+ H +T NR++R++++G VLY LR+T C
Sbjct: 132 IKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQ 191
Query: 162 MDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTR 221
+ L +PMD +C L+ S+GY ++ + W R + V RL Q++
Sbjct: 192 LQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEV 251
Query: 222 SQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTT 281
+ +G+Y + + F+L R + YF ++TY+P T +VVLSWVSFWI+ D+VPART +G+TT
Sbjct: 252 VKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITT 311
Query: 282 VLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRG 341
VL+MTTL +R SLP + ++ A+D+++ +CF FVF AL+EY HY + +KD+
Sbjct: 312 VLTMTTLSTIARKSLPKVS-YVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKD 370
Query: 342 TTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFRE---- 397
K+ +I S+ + ++ + Y L K F F +
Sbjct: 371 KKKKNPAPTIDIRPRSATIQMN---NATHLQERDEEYGYECLDGKDCASFFCCFEDCRTG 427
Query: 398 --KMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMY 439
+ GRI + I + +D Y+++ FP F L N+ YW Y+Y
Sbjct: 428 AWRHGRI--HIRI---AKMDSYARIFFPTAFCLFNLVYWVSYLY 466
>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
precursor [Homo sapiens]
Length = 475
Score = 254 bits (649), Expect = 1e-67
Identities = 139/409 (33%), Positives = 223/409 (54%), Gaps = 18/409 (4%)
Query: 43 NLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGN 102
NL GY+ LRP+ G +P I + + SI ++ NM+YT I+ Q W D+RL F
Sbjct: 72 NLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNST 131
Query: 103 -KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACN 161
K L++ +V +W+PDT+ SKK+ H +T NR++R++++G VLY LR+T C
Sbjct: 132 IKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQ 191
Query: 162 MDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTR 221
+ L +PMD +C L+ S+GY ++ + W R + V RL Q++
Sbjct: 192 LQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEV 251
Query: 222 SQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTT 281
+ +G+Y + + F+L R + YF ++TY+P T +VVLSWVSFWI+ D+VPART +G+TT
Sbjct: 252 VKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITT 311
Query: 282 VLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRG 341
VL+MTTL +R SLP + ++ A+D+++ +CF FVF AL+EY HY + +KD+
Sbjct: 312 VLTMTTLSTIARKSLPKVS-YVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKD 370
Query: 342 TTKEVEEVSITNIINSSISSFKRKISF-----ASIEISSDNVDYSDLTMKTSDKFKFVFR 396
K+ + + + +I R + ++ + Y L K F F
Sbjct: 371 KKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFE 430
Query: 397 E------KMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMY 439
+ + GRI + I + +D Y+++ FP F L N+ YW Y+Y
Sbjct: 431 DCRTGAWRHGRI--HIRI---AKMDSYARIFFPTAFCLFNLVYWVSYLY 474
>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
[Homo sapiens]
Length = 465
Score = 253 bits (645), Expect = 3e-67
Identities = 146/408 (35%), Positives = 221/408 (54%), Gaps = 24/408 (5%)
Query: 43 NLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGN 102
+L GY+ LRP+ G P I + + SI + NM+YT I Q W D RL F
Sbjct: 70 SLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNST 129
Query: 103 -KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACN 161
K L++ +V +W+PDT+ S+KS H +T NRL+R++++G VLY LR+T C
Sbjct: 130 MKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECY 189
Query: 162 MDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTR 221
+ L +PMD +C L+ S+GY N++E+ W + + V ++ RL Q+
Sbjct: 190 LQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEI 249
Query: 222 SQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTT 281
+ +G+Y + + F+L R + YF ++TY+P VVLSWVSFWI+ D+VPART +G+TT
Sbjct: 250 THTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITT 309
Query: 282 VLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQ---MAAK 338
VL+MTTL +R SLP + ++ A+D+++ +CF FVF AL+EY HY + Q A K
Sbjct: 310 VLTMTTLSTIARKSLPKVS-YVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTATK 368
Query: 339 DRGTTKEVEEVSITNIINSSISSFKRKISFASIEI-SSDNVDYSDLTMKTSDKFKFVFRE 397
DR K + S+T + I +I + D+ Y L K F F +
Sbjct: 369 DR---KLKNKASMT----PGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFED 421
Query: 398 ------KMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMY 439
+ GRI + I + +D YS++ FP F L N+ YW Y+Y
Sbjct: 422 CRTGSWREGRI--HIRI---AKIDSYSRIFFPTAFALFNLVYWVGYLY 464
>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
[Homo sapiens]
Length = 632
Score = 251 bits (640), Expect = 1e-66
Identities = 123/289 (42%), Positives = 183/289 (63%), Gaps = 2/289 (0%)
Query: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVF-E 100
+ + + Y+ LRPNFGG PV + +++ + SI ISE NMDYT T++ Q W D RL + E
Sbjct: 64 DRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYE 123
Query: 101 GNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
+ TLD R+ E LWVPD Y + SK +F+H+VTV NR+ +L +GTV Y +R+TTT AC
Sbjct: 124 TTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAAC 183
Query: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT 220
++DL K+PMD Q C L +ES+GY D+ W +++ E L + Q+T
Sbjct: 184 SLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITSK 243
Query: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280
TG+Y RL+L+F+++R V ++++ Y P+ + SW+SFW++ DS AR IG+T
Sbjct: 244 EVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLT 303
Query: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHY 329
++L +TT+ R LPN +C IKAID+Y+ +C FVF +LLEY +Y
Sbjct: 304 SMLILTTIDSHLRDKLPNISC-IKAIDIYILVCLFFVFLSLLEYVYINY 351
Score = 40.0 bits (92), Expect = 0.004
Identities = 18/37 (48%), Positives = 23/37 (62%), Gaps = 3/37 (8%)
Query: 406 FTIQNPS---NVDHYSKLLFPLIFMLANVFYWAYYMY 439
F + NP VD +S+ LFPL F L N+ YW Y+MY
Sbjct: 596 FDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYHMY 632
>gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor
[Homo sapiens]
Length = 492
Score = 243 bits (619), Expect = 3e-64
Identities = 138/413 (33%), Positives = 221/413 (53%), Gaps = 21/413 (5%)
Query: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101
+ L GY+ LRP G ++ + + S +S+++M+YT ++ RQ W D+RL F+G
Sbjct: 72 DRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDG 131
Query: 102 N-KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
K L+ L +W PDT+ KKS H +T N+L+RL NGT+LY +R+T C
Sbjct: 132 PMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAEC 191
Query: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRG-NDSVR-GLEHLRLAQYTIERYFTL 218
M L +PMD C L+ S+ Y +V ++W G N SV + RL QY + +
Sbjct: 192 PMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVG 251
Query: 219 VTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIG 278
+ TG Y + F L+R + YF+++TY+P V+LS VSFW++ +SVPART G
Sbjct: 252 TEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG 311
Query: 279 VTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAK 338
VTTVL+MTTL I +R SLP + A+D ++ +C++FVF AL+E+A +Y + + A +
Sbjct: 312 VTTVLTMTTLSISARNSLPKV-AYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWE 370
Query: 339 DRGTTKEVEEVSIT------------NIINSSIS-SFKRKISFASIEISSDNVDYSDLTM 385
+ + +E T NI+ ++ + + F++I + S T+
Sbjct: 371 GKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTI 430
Query: 386 KTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYM 438
S K +V + T + S VD S+++FP++F + N+ YWA Y+
Sbjct: 431 IASPKATYV----QDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYV 479
>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
[Homo sapiens]
Length = 453
Score = 242 bits (617), Expect = 6e-64
Identities = 147/450 (32%), Positives = 233/450 (51%), Gaps = 31/450 (6%)
Query: 7 LAFVCLSLFTE----RMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQ 62
L ++C+ L+ E ++ ++G+ ++ V R +NL GY+ LRP FGG +
Sbjct: 5 LPWLCIILWLENALGKLEVEGNFYSENVSRI-------LDNLLEGYDNRLRPGFGGAVTE 57
Query: 63 IALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG-NKSFTLDARLVEFLWVPDTY 121
+ + + S +S+ M+YT ++ RQ W D+RL F G + +L+ +V +W PDT+
Sbjct: 58 VKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTF 117
Query: 122 IVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESW 181
KKS H +T N+L R+ NGT+LY +R+T C M L +PMD C L+ S+
Sbjct: 118 FRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSY 177
Query: 182 GYDGNDVEFTWLRGN-DSVR-GLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELR 239
Y +++ +TW +G SV E L QY + + TG Y + + F L+
Sbjct: 178 AYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQ 237
Query: 240 RNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNT 299
R + YF+++ Y P V+LS VSFWI+ +SVPART G+TTVL+MTTL I +R SLP
Sbjct: 238 RKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKV 297
Query: 300 NCFIKAIDVYLGICFSFVFGALLEYAVAHY-SSLQQMAAKDRGTTKEVEEVSITNIIN-- 356
+ + A+D ++ +CF+FVF AL+E+A +Y ++LQ AK + V+I+
Sbjct: 298 S-YATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPL 356
Query: 357 --------SSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTI 408
S K++I+ S+ I S + LT + V +
Sbjct: 357 EAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSP-----AF 411
Query: 409 QNPSNVDHYSKLLFPLIFMLANVFYWAYYM 438
S +D YS++LFP+ F N+ YW Y+
Sbjct: 412 GGTSKIDQYSRILFPVAFAGFNLVYWVVYL 441
>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
precursor [Homo sapiens]
Length = 462
Score = 239 bits (611), Expect = 3e-63
Identities = 138/411 (33%), Positives = 212/411 (51%), Gaps = 29/411 (7%)
Query: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101
+ L GY+ LRP G Q+ + + S +S++ M+YT ++ RQ W D+RL F+G
Sbjct: 54 DGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKG 113
Query: 102 N-KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
+ L+ L +W PDT+ KKS H +T N+L+RL +GT+LY +R+T + C
Sbjct: 114 PMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAEC 173
Query: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDS--VRGLEHLRLAQYTIERYFTL 218
M L +PMD C L+ S+ Y ++V + W G+ V + RL QY +
Sbjct: 174 PMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVG 233
Query: 219 VTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIG 278
TG YT + F L+R + YF+++TY+P V+LS VSFW++ +SVPART G
Sbjct: 234 TENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG 293
Query: 279 VTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMA-- 336
VTTVL+MTTL I +R SLP + A+D ++ +C++FVF AL+E+A +Y + + A
Sbjct: 294 VTTVLTMTTLSISARNSLPKV-AYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWD 352
Query: 337 ---AKDRGTTKEVEEVSI---TNIINSSISSFKRKISFASIEISSDN---VDYSDLTMKT 387
A + K+ EV + TN + S I + N V KT
Sbjct: 353 GKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKT 412
Query: 388 SDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYM 438
S+ K T + S +D S+++FP++F N+ YWA Y+
Sbjct: 413 SESKK--------------TYNSISKIDKMSRIVFPVLFGTFNLVYWATYL 449
>gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform 3
precursor [Homo sapiens]
Length = 515
Score = 238 bits (607), Expect = 8e-63
Identities = 140/449 (31%), Positives = 223/449 (49%), Gaps = 58/449 (12%)
Query: 43 NLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGN 102
NL GY+ LRP+ G +P I + + SI ++ NM+YT I+ Q W D+RL F
Sbjct: 72 NLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNST 131
Query: 103 -KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACN 161
K L++ +V +W+PDT+ SKK+ H +T NR++R++++G VLY LR+T C
Sbjct: 132 IKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQ 191
Query: 162 MDLSKYPMDTQTCKLQLESW---------------------------------------- 181
+ L +PMD +C L+ SW
Sbjct: 192 LQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISD 251
Query: 182 GYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRRN 241
GY ++ + W R + V RL Q++ + +G+Y + + F+L R
Sbjct: 252 GYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRR 311
Query: 242 VLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNC 301
+ YF ++TY+P T +VVLSWVSFWI+ D+VPART +G+TTVL+MTTL +R SLP +
Sbjct: 312 MGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVS- 370
Query: 302 FIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSISS 361
++ A+D+++ +CF FVF AL+EY HY + +KD+ K+ + + + +I
Sbjct: 371 YVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDI 430
Query: 362 FKRKISF-----ASIEISSDNVDYSDLTMKTSDKFKFVFRE------KMGRIVDYFTIQN 410
R + ++ + Y L K F F + + GRI + I
Sbjct: 431 RPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRI--HIRI-- 486
Query: 411 PSNVDHYSKLLFPLIFMLANVFYWAYYMY 439
+ +D Y+++ FP F L N+ YW Y+Y
Sbjct: 487 -AKMDSYARIFFPTAFCLFNLVYWVSYLY 514
>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
[Homo sapiens]
Length = 467
Score = 236 bits (602), Expect = 3e-62
Identities = 140/417 (33%), Positives = 215/417 (51%), Gaps = 33/417 (7%)
Query: 48 YNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGN-KSFT 106
Y+K LRP+ G +P I + + + SI +S NM+Y I+ Q W D RL F K T
Sbjct: 58 YDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILT 117
Query: 107 LDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSK 166
L++ +V +W+PDT SK + H +T N+L+R++++G +LY LR+T C + L
Sbjct: 118 LNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHN 177
Query: 167 YPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQET 226
+PMD +C L S+GY ++ + W + + + RL Q+
Sbjct: 178 FPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSA 237
Query: 227 GNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMT 286
G+Y + + FEL R + YF ++TY+P VVLSWVSFWI D+ PART +G+TTVL+MT
Sbjct: 238 GDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMT 297
Query: 287 TLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEV 346
TL +R SLP + ++ A+D+++ +CF FVF AL+EYA +Y S + + TT +
Sbjct: 298 TLSTIARKSLPRVS-YVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLL 356
Query: 347 ---------EEVSITNIINSSISSFKRKISFASIEISS--------DNVDYSDLTMKTSD 389
E +S+ N S+ R A I +++ D Y L K
Sbjct: 357 HPDSSRWIPERISLQAPSNYSLLDM-RPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQ 415
Query: 390 KFKFVFRE------KMGRI-VDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMY 439
F + E + GRI +D +D YS++ FP F+L N+ YW Y+Y
Sbjct: 416 SFFCCYEECKSGSWRKGRIHIDIL------ELDSYSRVFFPTSFLLFNLVYWVGYLY 466
>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
sapiens]
Length = 451
Score = 235 bits (600), Expect = 5e-62
Identities = 128/400 (32%), Positives = 221/400 (55%), Gaps = 8/400 (2%)
Query: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101
+ L GY+ LRP G ++ + + S +S+++M+YT ++ RQ+W D+RL F+G
Sbjct: 47 DRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKG 106
Query: 102 NKSFT-LDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
+ L+ + +W PDT+ KKS H +T+ N+L+R+ +GT+LY +R+T C
Sbjct: 107 PMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAEC 166
Query: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWL-RGNDSVR-GLEHLRLAQYTIERYFTL 218
M L +PMD +C L+ S+ Y ++V + W +DSV+ + RL QY +
Sbjct: 167 PMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIG 226
Query: 219 VTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIG 278
+ TG YT + F L+R + YF+++TY+P V+LS VSFW++ +SVPART G
Sbjct: 227 KETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG 286
Query: 279 VTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAK 338
VTTVL+MTTL I +R SLP + A+D ++ +C++FVF AL+E+A +Y + + A
Sbjct: 287 VTTVLTMTTLSISARNSLPKV-AYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWD 345
Query: 339 DRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREK 398
+ + ++ + +I + +++ ++ + +S D V + T+ + K
Sbjct: 346 GKSVVNDKKKEKASVMIQN--NAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENK 403
Query: 399 MGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYM 438
T + S +D S+++FP++F N+ YWA Y+
Sbjct: 404 PAEAKK--TFNSVSKIDRMSRIVFPVLFGTFNLVYWATYL 441
>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
[Homo sapiens]
Length = 451
Score = 235 bits (600), Expect = 5e-62
Identities = 128/400 (32%), Positives = 221/400 (55%), Gaps = 8/400 (2%)
Query: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101
+ L GY+ LRP G ++ + + S +S+++M+YT ++ RQ+W D+RL F+G
Sbjct: 47 DRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKG 106
Query: 102 NKSFT-LDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
+ L+ + +W PDT+ KKS H +T+ N+L+R+ +GT+LY +R+T C
Sbjct: 107 PMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAEC 166
Query: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWL-RGNDSVR-GLEHLRLAQYTIERYFTL 218
M L +PMD +C L+ S+ Y ++V + W +DSV+ + RL QY +
Sbjct: 167 PMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIG 226
Query: 219 VTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIG 278
+ TG YT + F L+R + YF+++TY+P V+LS VSFW++ +SVPART G
Sbjct: 227 KETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG 286
Query: 279 VTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAK 338
VTTVL+MTTL I +R SLP + A+D ++ +C++FVF AL+E+A +Y + + A
Sbjct: 287 VTTVLTMTTLSISARNSLPKV-AYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWD 345
Query: 339 DRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREK 398
+ + ++ + +I + +++ ++ + +S D V + T+ + K
Sbjct: 346 GKSVVNDKKKEKASVMIQN--NAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENK 403
Query: 399 MGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYM 438
T + S +D S+++FP++F N+ YWA Y+
Sbjct: 404 PAEAKK--TFNSVSKIDRMSRIVFPVLFGTFNLVYWATYL 441
>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
[Homo sapiens]
Length = 554
Score = 233 bits (595), Expect = 2e-61
Identities = 127/350 (36%), Positives = 200/350 (57%), Gaps = 15/350 (4%)
Query: 7 LAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGF----ENLTAGYNKFLRPNFGGEPVQ 62
L F+CL++ C+ S + + +KL F ++L GY+ LRP FGG +
Sbjct: 21 LRFLCLAV-----CLNESPGQNQ--KEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTE 73
Query: 63 IALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGN-KSFTLDARLVEFLWVPDTY 121
+ + + S +S+ M+YT ++ RQ W+D+RL ++G + L+ +V +W PDT+
Sbjct: 74 VKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTF 133
Query: 122 IVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESW 181
KKS H +T N+L R+ NGT+LY +R+T + C M L +PMD C L+ S+
Sbjct: 134 FRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSY 193
Query: 182 GYDGNDVEFTWLRGNDSVRGL--EHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELR 239
Y +++ +TW +G + + E L QY + + TG Y + + F LR
Sbjct: 194 AYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLR 253
Query: 240 RNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNT 299
R + YF+++TY+P V+LS VSFWI+ +SVPART G+TTVL+MTTL I +R SLP
Sbjct: 254 RKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKV 313
Query: 300 NCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEV 349
+ + A+D ++ +CF+FVF AL+E+A +Y + QM R T+K +EV
Sbjct: 314 S-YATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEV 362
Score = 32.7 bits (73), Expect = 0.67
Identities = 11/27 (40%), Positives = 18/27 (66%)
Query: 412 SNVDHYSKLLFPLIFMLANVFYWAYYM 438
S +D Y+++LFP+ F N+ YW Y+
Sbjct: 516 SKIDKYARILFPVTFGAFNMVYWVVYL 542
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,196,475
Number of Sequences: 37866
Number of extensions: 552797
Number of successful extensions: 1759
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1490
Number of HSP's gapped (non-prelim): 104
length of query: 440
length of database: 18,247,518
effective HSP length: 105
effective length of query: 335
effective length of database: 14,271,588
effective search space: 4780981980
effective search space used: 4780981980
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.