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Search of human proteins with 76563908
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|76563908 hypothetical protein LOC169436 [Homo sapiens]
(680 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|76563908 hypothetical protein LOC169436 [Homo sapiens] 1339 0.0
gi|29826329 p21-activated kinase 7 [Homo sapiens] 82 1e-15
gi|24308191 p21-activated kinase 7 [Homo sapiens] 82 1e-15
gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo sapi... 75 2e-13
gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo sapi... 75 2e-13
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 75 2e-13
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 75 2e-13
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 74 3e-13
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 74 3e-13
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 74 4e-13
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 74 4e-13
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 74 6e-13
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 73 1e-12
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 72 1e-12
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 72 2e-12
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 72 2e-12
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 72 2e-12
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 71 3e-12
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 71 3e-12
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 71 3e-12
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 70 5e-12
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 70 5e-12
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 70 5e-12
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 70 5e-12
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 70 5e-12
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 70 6e-12
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 70 6e-12
gi|32483399 p21-activated kinase 2 [Homo sapiens] 69 1e-11
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 69 1e-11
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 69 1e-11
>gi|76563908 hypothetical protein LOC169436 [Homo sapiens]
Length = 680
Score = 1339 bits (3465), Expect = 0.0
Identities = 680/680 (100%), Positives = 680/680 (100%)
Query: 1 MLGPGSNRRRPTQGERGPGSPGEPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE 60
MLGPGSNRRRPTQGERGPGSPGEPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE
Sbjct: 1 MLGPGSNRRRPTQGERGPGSPGEPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE 60
Query: 61 CMDDHYASQALEELMPLLKLRHAHISVYQELFITWNGEISSLYLCLVMEFNELSFQEVIE 120
CMDDHYASQALEELMPLLKLRHAHISVYQELFITWNGEISSLYLCLVMEFNELSFQEVIE
Sbjct: 61 CMDDHYASQALEELMPLLKLRHAHISVYQELFITWNGEISSLYLCLVMEFNELSFQEVIE 120
Query: 121 DKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNV 180
DKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNV
Sbjct: 121 DKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNV 180
Query: 181 LMTDKAKWNIRAEEDPFRKSWMAPEALNFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMH 240
LMTDKAKWNIRAEEDPFRKSWMAPEALNFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMH
Sbjct: 181 LMTDKAKWNIRAEEDPFRKSWMAPEALNFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMH 240
Query: 241 LRKSLRQSPGSLKAVLKTMEEKQIPDVETFRNLLPLMLQIDPSDRITIKDVVHITFLRGS 300
LRKSLRQSPGSLKAVLKTMEEKQIPDVETFRNLLPLMLQIDPSDRITIKDVVHITFLRGS
Sbjct: 241 LRKSLRQSPGSLKAVLKTMEEKQIPDVETFRNLLPLMLQIDPSDRITIKDVVHITFLRGS 300
Query: 301 FKSSCVSLTLHRQMVPASITDMLLEGNVASILEVMQKFSGWPEVQLRAMKRLLKMPADQL 360
FKSSCVSLTLHRQMVPASITDMLLEGNVASILEVMQKFSGWPEVQLRAMKRLLKMPADQL
Sbjct: 301 FKSSCVSLTLHRQMVPASITDMLLEGNVASILEVMQKFSGWPEVQLRAMKRLLKMPADQL 360
Query: 361 GLPWPPELVEVVVTTMELHDRVLDVQLCACSLLLHLLGQALVHHPEAKAPCNQAITSTLL 420
GLPWPPELVEVVVTTMELHDRVLDVQLCACSLLLHLLGQALVHHPEAKAPCNQAITSTLL
Sbjct: 361 GLPWPPELVEVVVTTMELHDRVLDVQLCACSLLLHLLGQALVHHPEAKAPCNQAITSTLL 420
Query: 421 SALQSHPEEEPLLVMVYSLLAITTTQESESLSEELQNAGLLEHILEHLNSSLKSRDVCAS 480
SALQSHPEEEPLLVMVYSLLAITTTQESESLSEELQNAGLLEHILEHLNSSLKSRDVCAS
Sbjct: 421 SALQSHPEEEPLLVMVYSLLAITTTQESESLSEELQNAGLLEHILEHLNSSLKSRDVCAS 480
Query: 481 GLGLLWALLLDGIIVNKAPLEKVPDLISQVLATYPADGEMAEASCGVFWLLSLLGCIKEQ 540
GLGLLWALLLDGIIVNKAPLEKVPDLISQVLATYPADGEMAEASCGVFWLLSLLGCIKEQ
Sbjct: 481 GLGLLWALLLDGIIVNKAPLEKVPDLISQVLATYPADGEMAEASCGVFWLLSLLGCIKEQ 540
Query: 541 QFEQVVALLLQSIRLCQDRALLVNNAYRGLASLVKVSELAAFKVVVQEEGGSGLSLIKET 600
QFEQVVALLLQSIRLCQDRALLVNNAYRGLASLVKVSELAAFKVVVQEEGGSGLSLIKET
Sbjct: 541 QFEQVVALLLQSIRLCQDRALLVNNAYRGLASLVKVSELAAFKVVVQEEGGSGLSLIKET 600
Query: 601 YQLHRDDPEVVENVGMLLVHLASYEEILPELVSSSMKALLQEIKERFTSSLVSDSSAFSK 660
YQLHRDDPEVVENVGMLLVHLASYEEILPELVSSSMKALLQEIKERFTSSLVSDSSAFSK
Sbjct: 601 YQLHRDDPEVVENVGMLLVHLASYEEILPELVSSSMKALLQEIKERFTSSLVSDSSAFSK 660
Query: 661 PGLPPGGSPQLGCTTSGGLE 680
PGLPPGGSPQLGCTTSGGLE
Sbjct: 661 PGLPPGGSPQLGCTTSGGLE 680
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 82.4 bits (202), Expect = 1e-15
Identities = 74/298 (24%), Positives = 134/298 (44%), Gaps = 40/298 (13%)
Query: 20 SPGEPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMPLLK 79
SPG+P E ++ G+ G+ + E T + +K+++ E++ +
Sbjct: 441 SPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRD 500
Query: 80 LRHAHISVYQELFITWNGEISSLYLCLVMEFNEL-SFQEVIEDKRKAKKIIDSEWMQNVL 138
H ++ ++ + L +VMEF E + +++ R ++ E + V
Sbjct: 501 YHHDNVVDMYSSYLVGDE------LWVVMEFLEGGALTDIVTHTR-----MNEEQIATVC 549
Query: 139 GQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFR 198
VL AL YLH+ +IHR++K +I+L S KL D + ++E P R
Sbjct: 550 LSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQV---------SKEVPKR 600
Query: 199 KS------WMAPEALN-FSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLR---KSLRQS 248
KS WMAPE ++ + + DIWSLG ++++M +DG +++R+
Sbjct: 601 KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEM-----IDGEPPYFNEPPLQAMRRI 655
Query: 249 PGSLKAVLKTMEEKQIPDVETFRNLLPLMLQIDPSDRITIKDVVHITFLRGSFKSSCV 306
SL +K + + R L LML +PS R T ++++ FL+ + SC+
Sbjct: 656 RDSLPPRVKDLHKVS----SVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCI 709
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 82.4 bits (202), Expect = 1e-15
Identities = 74/298 (24%), Positives = 134/298 (44%), Gaps = 40/298 (13%)
Query: 20 SPGEPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMPLLK 79
SPG+P E ++ G+ G+ + E T + +K+++ E++ +
Sbjct: 441 SPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRD 500
Query: 80 LRHAHISVYQELFITWNGEISSLYLCLVMEFNEL-SFQEVIEDKRKAKKIIDSEWMQNVL 138
H ++ ++ + L +VMEF E + +++ R ++ E + V
Sbjct: 501 YHHDNVVDMYSSYLVGDE------LWVVMEFLEGGALTDIVTHTR-----MNEEQIATVC 549
Query: 139 GQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFR 198
VL AL YLH+ +IHR++K +I+L S KL D + ++E P R
Sbjct: 550 LSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQV---------SKEVPKR 600
Query: 199 KS------WMAPEALN-FSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLR---KSLRQS 248
KS WMAPE ++ + + DIWSLG ++++M +DG +++R+
Sbjct: 601 KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEM-----IDGEPPYFNEPPLQAMRRI 655
Query: 249 PGSLKAVLKTMEEKQIPDVETFRNLLPLMLQIDPSDRITIKDVVHITFLRGSFKSSCV 306
SL +K + + R L LML +PS R T ++++ FL+ + SC+
Sbjct: 656 RDSLPPRVKDLHKVS----SVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCI 709
>gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo
sapiens]
Length = 592
Score = 75.5 bits (184), Expect = 2e-13
Identities = 79/294 (26%), Positives = 137/294 (46%), Gaps = 37/294 (12%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQV-ECMDDHYASQALEELMPLLKLRHA 83
ME Y+ L ++ G+ G + + T IK E + A+ E+ L + H
Sbjct: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
Query: 84 HISVYQELFITWNGEISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQVLD 143
++ E+F + LV EF + V+++ + ++S+ ++ L Q+L
Sbjct: 61 NLVNLIEVFR------QKKKIHLVFEFID---HTVLDELQHYCHGLESKRLRKYLFQILR 111
Query: 144 ALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKSWMA 203
A++YLH +IIHR++KP NI++ S KL D T A +I + R + A
Sbjct: 112 AIDYLHSNNIIHRDIKPENILVSQSGITKLCDF--GFARTLAAPGDIYTDYVATR-WYRA 168
Query: 204 PEAL--NFSFSQKSDIWSLGCIILDMT-------SCSFMD---------GTEAMHLRKSL 245
PE + + S+ + DIW+LGC+I++M S S +D G + HL+
Sbjct: 169 PELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIF 228
Query: 246 RQSPGSLKAVLKTME-----EKQIPDVE-TFRNLLPLMLQIDPSDRITIKDVVH 293
+SP VL ++ K+ P + +++ LQIDP+DRI+ D++H
Sbjct: 229 SKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLH 282
>gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo
sapiens]
Length = 455
Score = 75.5 bits (184), Expect = 2e-13
Identities = 79/294 (26%), Positives = 137/294 (46%), Gaps = 37/294 (12%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQV-ECMDDHYASQALEELMPLLKLRHA 83
ME Y+ L ++ G+ G + + T IK E + A+ E+ L + H
Sbjct: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 60
Query: 84 HISVYQELFITWNGEISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQVLD 143
++ E+F + LV EF + V+++ + ++S+ ++ L Q+L
Sbjct: 61 NLVNLIEVFR------QKKKIHLVFEFID---HTVLDELQHYCHGLESKRLRKYLFQILR 111
Query: 144 ALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKSWMA 203
A++YLH +IIHR++KP NI++ S KL D T A +I + R + A
Sbjct: 112 AIDYLHSNNIIHRDIKPENILVSQSGITKLCDF--GFARTLAAPGDIYTDYVATR-WYRA 168
Query: 204 PEAL--NFSFSQKSDIWSLGCIILDMT-------SCSFMD---------GTEAMHLRKSL 245
PE + + S+ + DIW+LGC+I++M S S +D G + HL+
Sbjct: 169 PELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIF 228
Query: 246 RQSPGSLKAVLKTME-----EKQIPDVE-TFRNLLPLMLQIDPSDRITIKDVVH 293
+SP VL ++ K+ P + +++ LQIDP+DRI+ D++H
Sbjct: 229 SKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLH 282
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 75.1 bits (183), Expect = 2e-13
Identities = 59/217 (27%), Positives = 107/217 (49%), Gaps = 18/217 (8%)
Query: 26 EKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE--CMDDHYASQALEELMPLLKLRHA 83
E Y+VLY + G+ G + V K+++ M + + E+ L +L+H
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 84 HISVYQELFITWNGEISSLYLCLVMEFNELS-FQEVIEDKRKAKKIIDSEWMQNVLGQVL 142
+I Y + I + ++ L +VME+ E VI K ++ +D E++ V+ Q+
Sbjct: 66 NIVRYYDRII----DRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121
Query: 143 DALEYLHHLD-----IIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPF 197
AL+ H ++HR+LKP+N+ L + KL D ++ + P+
Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPY 181
Query: 198 RKSWMAPEALN-FSFSQKSDIWSLGCIILDMTSCSFM 233
+M+PE +N S+++KSDIWSLGC++ ++ C+ M
Sbjct: 182 ---YMSPEQMNRMSYNEKSDIWSLGCLLYEL--CALM 213
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 75.1 bits (183), Expect = 2e-13
Identities = 68/283 (24%), Positives = 131/283 (46%), Gaps = 35/283 (12%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVEC--MDDHYASQALEELMPLLKLRH 82
MEKY L ++ G+ G ++V+ E ++VIK++ M ++ E+ L ++H
Sbjct: 1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
Query: 83 AHISVYQELFITWNGEISSLYLCLVMEFNELS--FQEVIEDKRKAKKIIDSEWMQNVLGQ 140
+I Y+E F E SLY+ VM++ E F+ + K + + + + Q
Sbjct: 61 PNIVQYRESF----EENGSLYI--VMDYCEGGDLFKRINAQKGV---LFQEDQILDWFVQ 111
Query: 141 VLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKS 200
+ AL+++H I+HR++K NI L +L D ++ + P+
Sbjct: 112 ICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPY--- 168
Query: 201 WMAPEAL-NFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLRQSPGSLKAVLKTM 259
+++PE N ++ KSDIW+LGC++ ++ C+ EA GS+K ++ +
Sbjct: 169 YLSPEICENKPYNNKSDIWALGCVLYEL--CTLKHAFEA-----------GSMKNLVLKI 215
Query: 260 EEKQIPDVE-----TFRNLLPLMLQIDPSDRITIKDVVHITFL 297
P V R+L+ + + +P DR ++ ++ F+
Sbjct: 216 ISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFI 258
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 74.3 bits (181), Expect = 3e-13
Identities = 78/311 (25%), Positives = 135/311 (43%), Gaps = 50/311 (16%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE--CMDDHYASQALEELMPLLKLRH 82
+++YQ L + GA G+ + + +K++ + +A +A EL+ L + H
Sbjct: 23 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 82
Query: 83 AHISVYQELFITWNG--EISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQ 140
+I +F E +YL VME + + +VI + +D E M +L Q
Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYL--VMELMDANLCQVIHME------LDHERMSYLLYQ 134
Query: 141 VLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKS 200
+L +++LH IIHR+LKPSNI++ S C L+ L + T A N +
Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLART--ACTNFMMTPYVVTRY 190
Query: 201 WMAPEA-LNFSFSQKSDIWSLGCIILDMT-SCSFMDGTEAMHLRKSLRQSPGSLKA-VLK 257
+ APE L + + DIWS+GCI+ ++ C GT+ + + + G+ A +K
Sbjct: 191 YRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMK 250
Query: 258 TME------------------EKQIPD-------------VETFRNLLPLMLQIDPSDRI 286
++ E+ PD R+LL ML IDP RI
Sbjct: 251 KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRI 310
Query: 287 TIKDVVHITFL 297
++ + + ++
Sbjct: 311 SVDEALRHPYI 321
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 74.3 bits (181), Expect = 3e-13
Identities = 78/311 (25%), Positives = 135/311 (43%), Gaps = 50/311 (16%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE--CMDDHYASQALEELMPLLKLRH 82
+++YQ L + GA G+ + + +K++ + +A +A EL+ L + H
Sbjct: 23 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 82
Query: 83 AHISVYQELFITWNG--EISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQ 140
+I +F E +YL VME + + +VI + +D E M +L Q
Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYL--VMELMDANLCQVIHME------LDHERMSYLLYQ 134
Query: 141 VLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKS 200
+L +++LH IIHR+LKPSNI++ S C L+ L + T A N +
Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLART--ACTNFMMTPYVVTRY 190
Query: 201 WMAPEA-LNFSFSQKSDIWSLGCIILDMT-SCSFMDGTEAMHLRKSLRQSPGSLKA-VLK 257
+ APE L + + DIWS+GCI+ ++ C GT+ + + + G+ A +K
Sbjct: 191 YRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMK 250
Query: 258 TME------------------EKQIPD-------------VETFRNLLPLMLQIDPSDRI 286
++ E+ PD R+LL ML IDP RI
Sbjct: 251 KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRI 310
Query: 287 TIKDVVHITFL 297
++ + + ++
Sbjct: 311 SVDEALRHPYI 321
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 73.9 bits (180), Expect = 4e-13
Identities = 76/331 (22%), Positives = 149/331 (45%), Gaps = 44/331 (13%)
Query: 3 GPGSNRRRPTQGERGPGSPGE-------PME---KYQVLYQLNPGALGVNLVVEEMETKV 52
G G R T+G GPG PGE P + +Y L + GA G+ + K
Sbjct: 8 GGGGGEPRRTEGV-GPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKT 66
Query: 53 KHVIKQVECMDDH-YASQALEELMPLLKLRHAHISVYQELFITWNGE-ISSLYLCLVMEF 110
+ IK++ + Y + L E+ LL+ RH ++ +++ E + +Y+ V +
Sbjct: 67 RVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDL 124
Query: 111 NELSFQEVIEDKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDH 170
E ++++ ++ + ++ + L Q+L L+Y+H +++HR+LKPSN+++ ++
Sbjct: 125 METDLYKLLKSQQ-----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD 179
Query: 171 CKLQDLSSNVLMTDKAKWNIRAEEDPFRKSWMAPEAL--NFSFSQKSDIWSLGCIILDMT 228
K+ D + + E + + APE + + +++ DIWS+GCI+ +M
Sbjct: 180 LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239
Query: 229 S-------CSFMD---------GTEAMH-----LRKSLRQSPGSLKAVLKTMEEKQIPDV 267
S ++D G+ + + R SL + K K P
Sbjct: 240 SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS 299
Query: 268 ET-FRNLLPLMLQIDPSDRITIKDVVHITFL 297
++ +LL ML +P+ RIT+++ + +L
Sbjct: 300 DSKALDLLDRMLTFNPNKRITVEEALAHPYL 330
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 73.9 bits (180), Expect = 4e-13
Identities = 76/331 (22%), Positives = 149/331 (45%), Gaps = 44/331 (13%)
Query: 3 GPGSNRRRPTQGERGPGSPGE-------PME---KYQVLYQLNPGALGVNLVVEEMETKV 52
G G R T+G GPG PGE P + +Y L + GA G+ + K
Sbjct: 8 GGGGGEPRRTEGV-GPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKT 66
Query: 53 KHVIKQVECMDDH-YASQALEELMPLLKLRHAHISVYQELFITWNGE-ISSLYLCLVMEF 110
+ IK++ + Y + L E+ LL+ RH ++ +++ E + +Y+ V +
Sbjct: 67 RVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDL 124
Query: 111 NELSFQEVIEDKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDH 170
E ++++ ++ + ++ + L Q+L L+Y+H +++HR+LKPSN+++ ++
Sbjct: 125 METDLYKLLKSQQ-----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD 179
Query: 171 CKLQDLSSNVLMTDKAKWNIRAEEDPFRKSWMAPEAL--NFSFSQKSDIWSLGCIILDMT 228
K+ D + + E + + APE + + +++ DIWS+GCI+ +M
Sbjct: 180 LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239
Query: 229 S-------CSFMD---------GTEAMH-----LRKSLRQSPGSLKAVLKTMEEKQIPDV 267
S ++D G+ + + R SL + K K P
Sbjct: 240 SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS 299
Query: 268 ET-FRNLLPLMLQIDPSDRITIKDVVHITFL 297
++ +LL ML +P+ RIT+++ + +L
Sbjct: 300 DSKALDLLDRMLTFNPNKRITVEEALAHPYL 330
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 73.6 bits (179), Expect = 6e-13
Identities = 59/241 (24%), Positives = 116/241 (48%), Gaps = 22/241 (9%)
Query: 3 GPGSNRRRPTQGERGPGSPGE-------PME---KYQVLYQLNPGALGVNLVVEEMETKV 52
G G R T+G GPG PGE P + +Y L + GA G+ + K
Sbjct: 8 GGGGGEPRRTEGV-GPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKT 66
Query: 53 KHVIKQVECMDDH-YASQALEELMPLLKLRHAHISVYQELFITWNGE-ISSLYLCLVMEF 110
+ IK++ + Y + L E+ LL+ RH ++ +++ E + +Y+ V +
Sbjct: 67 RVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDL 124
Query: 111 NELSFQEVIEDKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDH 170
E ++++ ++ + ++ + L Q+L L+Y+H +++HR+LKPSN+++ ++
Sbjct: 125 METDLYKLLKSQQ-----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD 179
Query: 171 CKLQDLSSNVLMTDKAKWNIRAEEDPFRKSWMAPEAL--NFSFSQKSDIWSLGCIILDMT 228
K+ D + + E + + APE + + +++ DIWS+GCI+ +M
Sbjct: 180 LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239
Query: 229 S 229
S
Sbjct: 240 S 240
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 72.8 bits (177), Expect = 1e-12
Identities = 70/301 (23%), Positives = 132/301 (43%), Gaps = 51/301 (16%)
Query: 15 ERGPGSPGEPMEKYQVLYQLNPGALGVNLVVE-EMETKVKH------------------V 55
E+ G G P+ ++Q L P +G N + +E K+
Sbjct: 3 EQSQGMQGPPVPQFQPQKALRPD-MGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVA 61
Query: 56 IKQVEC---MDDHYASQALEELMPLLKLRHAHISVYQELFITWNGEISSLYLCLVMEFNE 112
+K+V+ MD + ++E+ L +L H ++ Y FI N L +V+E +
Sbjct: 62 LKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNE------LNIVLELAD 115
Query: 113 LS-FQEVIEDKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHC 171
+I+ +K K++I + Q+ ALE++H ++HR++KP+N+ + ++
Sbjct: 116 AGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVV 175
Query: 172 KLQDLSSNVLMTDKAKWNIRAEEDPFRKSWMAPEALNFS-FSQKSDIWSLGCIILDMTSC 230
KL DL + K P+ +M+PE ++ + ++ KSDIWSLGC++ +M +
Sbjct: 176 KLGDLGLGRFFSSKTTAAHSLVGTPY---YMSPERIHENGYNFKSDIWSLGCLLYEMAA- 231
Query: 231 SFMDGTEAMHLRKSLRQSPGSLKAVLKTMEEKQIPDV------ETFRNLLPLMLQIDPSD 284
L+ +L ++ K +E+ P + E R L+ + + DP
Sbjct: 232 ----------LQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEK 281
Query: 285 R 285
R
Sbjct: 282 R 282
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 72.4 bits (176), Expect = 1e-12
Identities = 87/369 (23%), Positives = 149/369 (40%), Gaps = 32/369 (8%)
Query: 23 EPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMPLLKLRH 82
+P E + VL +L G+ G ET IKQV D + ++E+ + +
Sbjct: 25 QPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESD--LQEIIKEISIMQQCDS 82
Query: 83 AHISVYQELFITWNGEISSLYLCLVMEF-NELSFQEVIEDKRKAKKIIDSEWMQNVLGQV 141
H+ Y + + L +VME+ S ++I R K + + + +L
Sbjct: 83 PHVVKY------YGSYFKNTDLWIVMEYCGAGSVSDII---RLRNKTLTEDEIATILQST 133
Query: 142 LDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKSW 201
L LEYLH + IHR++K NI+L + H KL D +TD PF W
Sbjct: 134 LKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF---W 190
Query: 202 MAPEAL-NFSFSQKSDIWSLGCIILDMTSCS--FMDGTEAMHLRKSLRQSPGSLKAVLKT 258
MAPE + ++ +DIWSLG ++M + D +H +++ P + +
Sbjct: 191 MAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD----IHPMRAIFMIPTNPPPTFRK 246
Query: 259 MEEKQIPDVETFRNLLPLMLQIDPSDRITIKDVVHITFLRGSFKSSCVSLTLHRQMVPAS 318
E + F + + L P R T ++ F+R S +++ R ++ +
Sbjct: 247 PELWS----DNFTDFVKQCLVKSPEQRATATQLLQHPFVR-----SAKGVSILRDLINEA 297
Query: 319 ITDMLLEGNVASILEVMQKFSGWPEVQLRAMKRLLKMPADQLGLPWPPELVEVVVTTMEL 378
+ D+ L+ + EV Q E +++ D++G + TM
Sbjct: 298 M-DVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIE 356
Query: 379 HDRVLDVQL 387
HD L QL
Sbjct: 357 HDDTLPSQL 365
>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
[Homo sapiens]
Length = 242
Score = 72.0 bits (175), Expect = 2e-12
Identities = 62/219 (28%), Positives = 104/219 (47%), Gaps = 18/219 (8%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE--CMDDHYASQALEELMPLLKLRH 82
+++YQ L + GA G+ + + +K++ + +A +A EL+ L + H
Sbjct: 23 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 82
Query: 83 AHISVYQELFITWNG--EISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQ 140
+I +F E +YL VME + + +VI + +D E M +L Q
Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYL--VMELMDANLCQVIHME------LDHERMSYLLYQ 134
Query: 141 VLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKS 200
+L +++LH IIHR+LKPSNI++ S C L+ L + T A N +
Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLART--ACTNFMMTPYVVTRY 190
Query: 201 WMAPEA-LNFSFSQKSDIWSLGCIILDMT-SCSFMDGTE 237
+ APE L + + DIWS+GCI+ ++ C GT+
Sbjct: 191 YRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTD 229
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 72.0 bits (175), Expect = 2e-12
Identities = 69/256 (26%), Positives = 113/256 (44%), Gaps = 29/256 (11%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE--CMDDHYASQALEELMPLLKLRH 82
+++YQ L + GA G+ + + +K++ + +A +A EL+ L + H
Sbjct: 23 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 82
Query: 83 AHISVYQELFITWNG--EISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQ 140
+I +F E +YL VME + + +VI + +D E M +L Q
Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYL--VMELMDANLCQVIHME------LDHERMSYLLYQ 134
Query: 141 VLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKS 200
+L +++LH IIHR+LKPSNI++ S C L+ L + T A N +
Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLART--ACTNFMMTPYVVTRY 190
Query: 201 WMAPEA-LNFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLRQSPGSLKAVLKTM 259
+ APE L + + DIWS+GCI+ +M L K L + K +
Sbjct: 191 YRAPEVILGMGYKENVDIWSVGCIMAEMV------------LHKVLFPGRDYIDQWNKVI 238
Query: 260 EEKQIPDVETFRNLLP 275
E+ P E + L P
Sbjct: 239 EQLGTPSAEFMKKLQP 254
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 72.0 bits (175), Expect = 2e-12
Identities = 69/256 (26%), Positives = 113/256 (44%), Gaps = 29/256 (11%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE--CMDDHYASQALEELMPLLKLRH 82
+++YQ L + GA G+ + + +K++ + +A +A EL+ L + H
Sbjct: 23 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 82
Query: 83 AHISVYQELFITWNG--EISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQ 140
+I +F E +YL VME + + +VI + +D E M +L Q
Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYL--VMELMDANLCQVIHME------LDHERMSYLLYQ 134
Query: 141 VLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKS 200
+L +++LH IIHR+LKPSNI++ S C L+ L + T A N +
Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLART--ACTNFMMTPYVVTRY 190
Query: 201 WMAPEA-LNFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLRQSPGSLKAVLKTM 259
+ APE L + + DIWS+GCI+ +M L K L + K +
Sbjct: 191 YRAPEVILGMGYKENVDIWSVGCIMAEMV------------LHKVLFPGRDYIDQWNKVI 238
Query: 260 EEKQIPDVETFRNLLP 275
E+ P E + L P
Sbjct: 239 EQLGTPSAEFMKKLQP 254
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/207 (25%), Positives = 102/207 (49%), Gaps = 16/207 (7%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQ-ALEELMPLLKLRHA 83
M+ Y VL + G+ G L+V+ + +K++ +Q + +E + L K++H
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
Query: 84 HISVYQELFITWNGEISSLYLCLVMEFNELS--FQEVIEDKRKAKKIIDSEWMQNVLGQV 141
+I ++E F +L +VME+ + Q++ K++ K+ + + N Q+
Sbjct: 61 NIVAFKESFEAEG------HLYIVMEYCDGGDLMQKI---KQQKGKLFPEDMILNWFTQM 111
Query: 142 LDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKSW 201
+ ++H ++HR++K NI L + KL D S L+++ + P+ +
Sbjct: 112 CLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPY---Y 168
Query: 202 MAPEAL-NFSFSQKSDIWSLGCIILDM 227
+ PE N ++ KSDIWSLGCI+ ++
Sbjct: 169 VPPEIWENLPYNNKSDIWSLGCILYEL 195
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/207 (25%), Positives = 102/207 (49%), Gaps = 16/207 (7%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQ-ALEELMPLLKLRHA 83
M+ Y VL + G+ G L+V+ + +K++ +Q + +E + L K++H
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
Query: 84 HISVYQELFITWNGEISSLYLCLVMEFNELS--FQEVIEDKRKAKKIIDSEWMQNVLGQV 141
+I ++E F +L +VME+ + Q++ K++ K+ + + N Q+
Sbjct: 61 NIVAFKESFEAEG------HLYIVMEYCDGGDLMQKI---KQQKGKLFPEDMILNWFTQM 111
Query: 142 LDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKSW 201
+ ++H ++HR++K NI L + KL D S L+++ + P+ +
Sbjct: 112 CLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPY---Y 168
Query: 202 MAPEAL-NFSFSQKSDIWSLGCIILDM 227
+ PE N ++ KSDIWSLGCI+ ++
Sbjct: 169 VPPEIWENLPYNNKSDIWSLGCILYEL 195
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/207 (25%), Positives = 102/207 (49%), Gaps = 16/207 (7%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQ-ALEELMPLLKLRHA 83
M+ Y VL + G+ G L+V+ + +K++ +Q + +E + L K++H
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
Query: 84 HISVYQELFITWNGEISSLYLCLVMEFNELS--FQEVIEDKRKAKKIIDSEWMQNVLGQV 141
+I ++E F +L +VME+ + Q++ K++ K+ + + N Q+
Sbjct: 61 NIVAFKESFEAEG------HLYIVMEYCDGGDLMQKI---KQQKGKLFPEDMILNWFTQM 111
Query: 142 LDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKSW 201
+ ++H ++HR++K NI L + KL D S L+++ + P+ +
Sbjct: 112 CLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPY---Y 168
Query: 202 MAPEAL-NFSFSQKSDIWSLGCIILDM 227
+ PE N ++ KSDIWSLGCI+ ++
Sbjct: 169 VPPEIWENLPYNNKSDIWSLGCILYEL 195
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 70.5 bits (171), Expect = 5e-12
Identities = 68/285 (23%), Positives = 127/285 (44%), Gaps = 30/285 (10%)
Query: 20 SPGEPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMPLLK 79
S G+P +KY ++ GA G ++ T + IKQ+ + E++ + +
Sbjct: 262 SVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRE 321
Query: 80 LRHAHISVYQELFITWNGEISSLYLCLVMEFNEL-SFQEVIEDKRKAKKIIDSEWMQNVL 138
++ +I Y + ++ + L +VME+ S +V+ + +D + V
Sbjct: 322 NKNPNIVNYLDSYLVGDE------LWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVC 370
Query: 139 GQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFR 198
+ L ALE+LH +IHR++K NI+L KL D +T + P+
Sbjct: 371 RECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPY- 429
Query: 199 KSWMAPEAL-NFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLRQSPGSLKAVLK 257
WMAPE + ++ K DIWSLG + ++M ++G L ++P ++
Sbjct: 430 --WMAPEVVTRKAYGPKVDIWSLGIMAIEM-----IEGEPPY-----LNENPLRALYLIA 477
Query: 258 TMEEKQIPDVE----TFRNLLPLMLQIDPSDRITIKDVVHITFLR 298
T ++ + E FR+ L L++D R + K+++ + LR
Sbjct: 478 TNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKLR 522
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 70.5 bits (171), Expect = 5e-12
Identities = 68/285 (23%), Positives = 127/285 (44%), Gaps = 30/285 (10%)
Query: 20 SPGEPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMPLLK 79
S G+P +KY ++ GA G ++ T + IKQ+ + E++ + +
Sbjct: 262 SVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRE 321
Query: 80 LRHAHISVYQELFITWNGEISSLYLCLVMEFNEL-SFQEVIEDKRKAKKIIDSEWMQNVL 138
++ +I Y + ++ + L +VME+ S +V+ + +D + V
Sbjct: 322 NKNPNIVNYLDSYLVGDE------LWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVC 370
Query: 139 GQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFR 198
+ L ALE+LH +IHR++K NI+L KL D +T + P+
Sbjct: 371 RECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPY- 429
Query: 199 KSWMAPEAL-NFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLRQSPGSLKAVLK 257
WMAPE + ++ K DIWSLG + ++M ++G L ++P ++
Sbjct: 430 --WMAPEVVTRKAYGPKVDIWSLGIMAIEM-----IEGEPPY-----LNENPLRALYLIA 477
Query: 258 TMEEKQIPDVE----TFRNLLPLMLQIDPSDRITIKDVVHITFLR 298
T ++ + E FR+ L L++D R + K+++ FL+
Sbjct: 478 TNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLK 522
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 70.5 bits (171), Expect = 5e-12
Identities = 74/301 (24%), Positives = 135/301 (44%), Gaps = 35/301 (11%)
Query: 26 EKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHY--ASQALEELMPLLKLRHA 83
++Y+++ + GA GV T + IK++ D A + L EL L +H
Sbjct: 53 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 112
Query: 84 HISVYQELF--ITWNGEISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQV 141
+I +++ GE S+Y+ V++ E ++I + + E ++ L Q+
Sbjct: 113 NIIAIKDILRPTVPYGEFKSVYV--VLDLMESDLHQIIHSSQP----LTLEHVRYFLYQL 166
Query: 142 LDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLS-SNVLMTDKAKWNIRAEEDPFRKS 200
L L+Y+H +IHR+LKPSN+++ + K+ D + L T A+ E +
Sbjct: 167 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 226
Query: 201 WMAPEAL--NFSFSQKSDIWSLGCIILDMTS-CSFMDGTEAMHLRKSLRQ-----SPGSL 252
+ APE + ++Q D+WS+GCI +M + G +H + + SP +
Sbjct: 227 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 286
Query: 253 KAV--------LKTMEEKQIPDVETF--------RNLLPLMLQIDPSDRITIKDVVHITF 296
+AV ++++ +Q ET +LL ML+ +PS RI+ + F
Sbjct: 287 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 346
Query: 297 L 297
L
Sbjct: 347 L 347
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 70.5 bits (171), Expect = 5e-12
Identities = 74/301 (24%), Positives = 135/301 (44%), Gaps = 35/301 (11%)
Query: 26 EKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHY--ASQALEELMPLLKLRHA 83
++Y+++ + GA GV T + IK++ D A + L EL L +H
Sbjct: 53 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 112
Query: 84 HISVYQELF--ITWNGEISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQV 141
+I +++ GE S+Y+ V++ E ++I + + E ++ L Q+
Sbjct: 113 NIIAIKDILRPTVPYGEFKSVYV--VLDLMESDLHQIIHSSQP----LTLEHVRYFLYQL 166
Query: 142 LDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLS-SNVLMTDKAKWNIRAEEDPFRKS 200
L L+Y+H +IHR+LKPSN+++ + K+ D + L T A+ E +
Sbjct: 167 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 226
Query: 201 WMAPEAL--NFSFSQKSDIWSLGCIILDMTS-CSFMDGTEAMHLRKSLRQ-----SPGSL 252
+ APE + ++Q D+WS+GCI +M + G +H + + SP +
Sbjct: 227 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 286
Query: 253 KAV--------LKTMEEKQIPDVETF--------RNLLPLMLQIDPSDRITIKDVVHITF 296
+AV ++++ +Q ET +LL ML+ +PS RI+ + F
Sbjct: 287 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 346
Query: 297 L 297
L
Sbjct: 347 L 347
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 70.5 bits (171), Expect = 5e-12
Identities = 74/301 (24%), Positives = 135/301 (44%), Gaps = 35/301 (11%)
Query: 26 EKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHY--ASQALEELMPLLKLRHA 83
++Y+++ + GA GV T + IK++ D A + L EL L +H
Sbjct: 53 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 112
Query: 84 HISVYQELF--ITWNGEISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQV 141
+I +++ GE S+Y+ V++ E ++I + + E ++ L Q+
Sbjct: 113 NIIAIKDILRPTVPYGEFKSVYV--VLDLMESDLHQIIHSSQP----LTLEHVRYFLYQL 166
Query: 142 LDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLS-SNVLMTDKAKWNIRAEEDPFRKS 200
L L+Y+H +IHR+LKPSN+++ + K+ D + L T A+ E +
Sbjct: 167 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 226
Query: 201 WMAPEAL--NFSFSQKSDIWSLGCIILDMTS-CSFMDGTEAMHLRKSLRQ-----SPGSL 252
+ APE + ++Q D+WS+GCI +M + G +H + + SP +
Sbjct: 227 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 286
Query: 253 KAV--------LKTMEEKQIPDVETF--------RNLLPLMLQIDPSDRITIKDVVHITF 296
+AV ++++ +Q ET +LL ML+ +PS RI+ + F
Sbjct: 287 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 346
Query: 297 L 297
L
Sbjct: 347 L 347
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 70.1 bits (170), Expect = 6e-12
Identities = 80/311 (25%), Positives = 137/311 (44%), Gaps = 50/311 (16%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE--CMDDHYASQALEELMPLLKLRH 82
+++YQ L + GA G+ + + IK++ + +A +A EL+ + + H
Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82
Query: 83 AHISVYQELFITWNG--EISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQ 140
+I +F E +Y+ VME + + +VI+ + +D E M +L Q
Sbjct: 83 KNIIGLLNVFTPQKSLEEFQDVYI--VMELMDANLCQVIQME------LDHERMSYLLYQ 134
Query: 141 VLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKS 200
+L +++LH IIHR+LKPSNI++ S C L+ L + T A + +
Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLART--AGTSFMMTPYVVTRY 190
Query: 201 WMAPEA-LNFSFSQKSDIWSLGCIILDMTSCSFM-DGTEAM-HLRKSLRQ----SPGSLK 253
+ APE L + + DIWS+GCI+ +M + GT+ + K + Q P +K
Sbjct: 191 YRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK 250
Query: 254 AVLKTME--------------EKQIPDV-------------ETFRNLLPLMLQIDPSDRI 286
+ T+ EK PDV R+LL ML ID S RI
Sbjct: 251 KLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRI 310
Query: 287 TIKDVVHITFL 297
++ + + ++
Sbjct: 311 SVDEALQHPYI 321
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 70.1 bits (170), Expect = 6e-12
Identities = 80/311 (25%), Positives = 137/311 (44%), Gaps = 50/311 (16%)
Query: 25 MEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE--CMDDHYASQALEELMPLLKLRH 82
+++YQ L + GA G+ + + IK++ + +A +A EL+ + + H
Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82
Query: 83 AHISVYQELFITWNG--EISSLYLCLVMEFNELSFQEVIEDKRKAKKIIDSEWMQNVLGQ 140
+I +F E +Y+ VME + + +VI+ + +D E M +L Q
Sbjct: 83 KNIIGLLNVFTPQKSLEEFQDVYI--VMELMDANLCQVIQME------LDHERMSYLLYQ 134
Query: 141 VLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKS 200
+L +++LH IIHR+LKPSNI++ S C L+ L + T A + +
Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLART--AGTSFMMTPYVVTRY 190
Query: 201 WMAPEA-LNFSFSQKSDIWSLGCIILDMTSCSFM-DGTEAM-HLRKSLRQ----SPGSLK 253
+ APE L + + DIWS+GCI+ +M + GT+ + K + Q P +K
Sbjct: 191 YRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK 250
Query: 254 AVLKTME--------------EKQIPDV-------------ETFRNLLPLMLQIDPSDRI 286
+ T+ EK PDV R+LL ML ID S RI
Sbjct: 251 KLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRI 310
Query: 287 TIKDVVHITFL 297
++ + + ++
Sbjct: 311 SVDEALQHPYI 321
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 69.3 bits (168), Expect = 1e-11
Identities = 66/285 (23%), Positives = 127/285 (44%), Gaps = 30/285 (10%)
Query: 20 SPGEPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMPLLK 79
S G+P +KY ++ GA G ++ + IKQ+ + E++ + +
Sbjct: 241 SIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKE 300
Query: 80 LRHAHISVYQELFITWNGEISSLYLCLVMEFNEL-SFQEVIEDKRKAKKIIDSEWMQNVL 138
L++ +I + + ++ + L +VME+ S +V+ + +D + V
Sbjct: 301 LKNPNIVNFLDSYLVGDE------LFVVMEYLAGGSLTDVVTET-----CMDEAQIAAVC 349
Query: 139 GQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFR 198
+ L ALE+LH +IHR++K N++L KL D +T + P+
Sbjct: 350 RECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPY- 408
Query: 199 KSWMAPEAL-NFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLRQSPGSLKAVLK 257
WMAPE + ++ K DIWSLG + ++M ++G L ++P ++
Sbjct: 409 --WMAPEVVTRKAYGPKVDIWSLGIMAIEM-----VEGEPPY-----LNENPLRALYLIA 456
Query: 258 TMEEKQIPDVE----TFRNLLPLMLQIDPSDRITIKDVVHITFLR 298
T ++ + E FR+ L L++D R + K+++ FL+
Sbjct: 457 TNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLK 501
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 69.3 bits (168), Expect = 1e-11
Identities = 67/280 (23%), Positives = 130/280 (46%), Gaps = 24/280 (8%)
Query: 24 PMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQ--ALEELMPLLKLR 81
P+ Y L + G+ G +V+ ++VIK++ + + A +E L +L+
Sbjct: 2 PLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLK 61
Query: 82 HAHISVYQELFITWNGEISSLYLCLVMEFNELS--FQEVIEDKRKAKKIIDSEWMQNVLG 139
H +I Y+E +W G LY+ VM F E ++++ E K + ++ +
Sbjct: 62 HPNIVTYKE---SWEGGDGLLYI--VMGFCEGGDLYRKLKEQKGQ---LLPENQVVEWFV 113
Query: 140 QVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRK 199
Q+ AL+YLH I+HR+LK N+ L ++ K+ DL ++ + P+
Sbjct: 114 QIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPY-- 171
Query: 200 SWMAPEAL-NFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLRQSPGSLKAVLKT 258
+M+PE N ++ KSD+W+LGC + +M + + M+ SL ++ L
Sbjct: 172 -YMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMN---SLVYR--IIEGKLPP 225
Query: 259 MEEKQIPDVETFRNLLPLMLQIDPSDRITIKDVVHITFLR 298
M P++ L+ ML P +R +++ ++ +++
Sbjct: 226 MPRDYSPEL---AELIRTMLSKRPEERPSVRSILRQPYIK 262
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 69.3 bits (168), Expect = 1e-11
Identities = 60/207 (28%), Positives = 95/207 (45%), Gaps = 16/207 (7%)
Query: 23 EPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMPLLKLRH 82
+P E + VL +L G+ G E+ IKQV D L+E++ + +
Sbjct: 22 QPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD------LQEIIKEISIMQ 75
Query: 83 AHISVYQELFITWNGEISSLYLCLVMEF-NELSFQEVIEDKRKAKKIIDSEWMQNVLGQV 141
S Y + + + L +VME+ S ++I + + K +I+ E + +L
Sbjct: 76 QCDSPYVVKY--YGSYFKNTDLWIVMEYCGAGSVSDII--RLRNKTLIEDE-IATILKST 130
Query: 142 LDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKSW 201
L LEYLH + IHR++K NI+L + H KL D +TD PF W
Sbjct: 131 LKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF---W 187
Query: 202 MAPEAL-NFSFSQKSDIWSLGCIILDM 227
MAPE + ++ +DIWSLG ++M
Sbjct: 188 MAPEVIQEIGYNCVADIWSLGITSIEM 214
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,096,291
Number of Sequences: 37866
Number of extensions: 1142461
Number of successful extensions: 5113
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 577
Number of HSP's successfully gapped in prelim test: 228
Number of HSP's that attempted gapping in prelim test: 3817
Number of HSP's gapped (non-prelim): 993
length of query: 680
length of database: 18,247,518
effective HSP length: 109
effective length of query: 571
effective length of database: 14,120,124
effective search space: 8062590804
effective search space used: 8062590804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.