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Search of human proteins with 75677351
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75677351 suppressor of defective silencing 3 [Homo sapiens]
(328 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75677351 suppressor of defective silencing 3 [Homo sapiens] 650 0.0
gi|34147416 breast cancer metastasis-suppressor 1-like [Homo sap... 133 2e-31
gi|68348702 breast cancer metastasis suppressor 1 isoform 2 [Hom... 73 4e-13
gi|17530785 breast cancer metastasis suppressor 1 isoform 1 [Hom... 71 1e-12
gi|38569484 kinesin family member 21A [Homo sapiens] 59 8e-09
gi|4758648 kinesin family member 5B [Homo sapiens] 51 1e-06
gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens] 50 2e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 50 4e-06
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 50 4e-06
gi|83716024 kinesin family member 21B [Homo sapiens] 50 4e-06
gi|221219026 pleckstrin homology-like domain, family B, member 1... 49 5e-06
gi|221219024 pleckstrin homology-like domain, family B, member 1... 49 5e-06
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 49 5e-06
gi|59806361 hypothetical protein LOC387104 [Homo sapiens] 49 6e-06
gi|32698688 citron [Homo sapiens] 48 1e-05
gi|148746195 trichohyalin [Homo sapiens] 48 1e-05
gi|94721321 coiled-coil domain containing 11 [Homo sapiens] 47 2e-05
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 47 2e-05
gi|221219020 NYD-SP11 protein [Homo sapiens] 47 2e-05
gi|38176300 nestin [Homo sapiens] 47 2e-05
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 47 2e-05
gi|109134347 NY-REN-58 antigen [Homo sapiens] 47 2e-05
gi|109134355 NY-REN-58 antigen [Homo sapiens] 47 2e-05
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 47 3e-05
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 47 3e-05
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 47 3e-05
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 47 3e-05
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 47 3e-05
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 47 3e-05
gi|112734867 retinitis pigmentosa GTPase regulator interacting p... 46 4e-05
>gi|75677351 suppressor of defective silencing 3 [Homo sapiens]
Length = 328
Score = 650 bits (1676), Expect = 0.0
Identities = 328/328 (100%), Positives = 328/328 (100%)
Query: 1 MSAAGLLAPAPAQAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKH 60
MSAAGLLAPAPAQAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKH
Sbjct: 1 MSAAGLLAPAPAQAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKH 60
Query: 61 DEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLE 120
DEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLE
Sbjct: 61 DEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLE 120
Query: 121 TEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPI 180
TEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPI
Sbjct: 121 TEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPI 180
Query: 181 MTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEH 240
MTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEH
Sbjct: 181 MTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEH 240
Query: 241 LPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVR 300
LPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVR
Sbjct: 241 LPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVR 300
Query: 301 KTSDSTKMRIYLGQLQRGLFVIRRRSAA 328
KTSDSTKMRIYLGQLQRGLFVIRRRSAA
Sbjct: 301 KTSDSTKMRIYLGQLQRGLFVIRRRSAA 328
>gi|34147416 breast cancer metastasis-suppressor 1-like [Homo
sapiens]
Length = 323
Score = 133 bits (334), Expect = 2e-31
Identities = 85/303 (28%), Positives = 157/303 (51%), Gaps = 17/303 (5%)
Query: 26 EDEELESAEDDERSCRGRESDEDTEDASET--DLAKHDEEDYVEMKEQMYQDKLASLKRQ 83
EDE+ ES+ E DED E D + E+ + ++K+Q+Y+++L+ + +
Sbjct: 31 EDEDTESSSVSEDGDSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAK 90
Query: 84 LQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKK 143
LQ++ G EY + + L + + R + A ++ +L E V+ Y E +A+ + E +K
Sbjct: 91 LQEVIAGKAPEYLEPLATLQENMQIRTKVAGIYRELCLESVKNKYECEIQASRQHCESEK 150
Query: 144 VELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPA 203
+ L + + +ELEEK + +E ++ ++++T + + +RK R+ P P ++KP
Sbjct: 151 LLLYDTVQSELEEKIRRLEEDRHSIDITSELWN-DELQSRKKRKDPFSP-----DKKKPV 204
Query: 204 PAQ---LNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDG 260
+ Y+L D I+ED T+ K + P + P + AR E+G
Sbjct: 205 VVSGPYIVYMLQDLDILEDWTTIRKAMATLGPHRVKT-----EPPVKLEKHLHSARSEEG 259
Query: 261 KLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVRKTSDSTKMRIYLGQLQRGLF 320
+LYYD WY + Q I ++ KD S VI+++ +E+W K D +K ++Y+ QLQ+G +
Sbjct: 260 RLYYDGEWYIRGQTICIDKKDECPTSAVITTINHDEVWF-KRPDGSKSKLYISQLQKGKY 318
Query: 321 VIR 323
I+
Sbjct: 319 SIK 321
>gi|68348702 breast cancer metastasis suppressor 1 isoform 2 [Homo
sapiens]
Length = 290
Score = 72.8 bits (177), Expect = 4e-13
Identities = 58/246 (23%), Positives = 121/246 (49%), Gaps = 24/246 (9%)
Query: 13 QAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHD----------E 62
+A A E EE+E ++ERS ES+E++ + + D + E
Sbjct: 14 EAEGDSAAEMNGEEEES-----EEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLE 68
Query: 63 EDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETE 122
+ + E+KE++++++L+ L+ +L+++ EY + + L + K RI+ A ++ +
Sbjct: 69 KQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQRSLKIRIQVAGIYKGFCLD 128
Query: 123 QVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMT 182
+ Y E + A + E +K+ L + L EL+E+ + +E ++ +++L+ + + K +
Sbjct: 129 VIRNKYECELQGAKQHLESEKLLLYDTLQGELQERIQRLEEDRQSLDLSSEWWDDK--LH 186
Query: 183 RKLRRRPNDPVPIPDKRRKP---APAQLNYLLTDEQIMEDLRTLNKLK---SPKRPASPS 236
+ R D +P P KR+K + + Y+L + I+ED + K + SP++ S
Sbjct: 187 ARGSSRSWDSLP-PSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKSDD 245
Query: 237 SPEHLP 242
H P
Sbjct: 246 RRTHRP 251
>gi|17530785 breast cancer metastasis suppressor 1 isoform 1 [Homo
sapiens]
Length = 246
Score = 71.2 bits (173), Expect = 1e-12
Identities = 55/238 (23%), Positives = 117/238 (49%), Gaps = 21/238 (8%)
Query: 13 QAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHD----------E 62
+A A E EE+E ++ERS ES+E++ + + D + E
Sbjct: 14 EAEGDSAAEMNGEEEES-----EEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLE 68
Query: 63 EDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETE 122
+ + E+KE++++++L+ L+ +L+++ EY + + L + K RI+ A ++ +
Sbjct: 69 KQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQRSLKIRIQVAGIYKGFCLD 128
Query: 123 QVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMT 182
+ Y E + A + E +K+ L + L EL+E+ + +E ++ +++L+ + + K +
Sbjct: 129 VIRNKYECELQGAKQHLESEKLLLYDTLQGELQERIQRLEEDRQSLDLSSEWWDDK--LH 186
Query: 183 RKLRRRPNDPVPIPDKRRKP---APAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSS 237
+ R D +P P KR+K + + Y+L + I+ED + K ++ P S
Sbjct: 187 ARGSSRSWDSLP-PSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKS 243
>gi|38569484 kinesin family member 21A [Homo sapiens]
Length = 1661
Score = 58.5 bits (140), Expect = 8e-09
Identities = 57/204 (27%), Positives = 97/204 (47%), Gaps = 28/204 (13%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
EE +E+ ED+E E +ED D E+ DE D ++ YQ LA++ ++
Sbjct: 589 EESQEVSDHEDEEEE---EEEEEDDIDGGESS----DESDSESDEKANYQADLANITCEI 641
Query: 85 QQLQE--GTLQEYQKRMKKLDQQYKERIRNAELFL---QLETEQVERN------YIKEKK 133
Q+ L+ QKR++ L +QY+E++ + + QLE +QV +N Y +EK
Sbjct: 642 AIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKA 701
Query: 134 AAVKEFEDKKVELK----ENLIAELEEKKKMIEN----EKLTMELTGDSMEVKPIMTR-- 183
V+ +KK++ + L A +E ++++N EK +L D ME+K R
Sbjct: 702 KKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLM 761
Query: 184 KLRRRPNDPVPIPDKRRKPAPAQL 207
K + + + + RR AQL
Sbjct: 762 KQMKEEQEKARLTESRRNREIAQL 785
Score = 38.5 bits (88), Expect = 0.008
Identities = 34/146 (23%), Positives = 69/146 (47%), Gaps = 23/146 (15%)
Query: 63 EDYVEMKEQM----YQDKLASLKRQLQQLQEGTLQ---------EYQKRMKKLDQQYKER 109
E Y E K + Y+ KL ++ ++LQ+LQ + +Y+K++KKL Q E
Sbjct: 694 ESYSEEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEM 753
Query: 110 IRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKEN---LIAELEEKKKMIENEKL 166
+ ++ E+ E+ + E + + + KK + K + + E +++ + + +
Sbjct: 754 KKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRK 813
Query: 167 TMELTGDSMEVKPI-------MTRKL 185
T E+T +V+P+ +TRKL
Sbjct: 814 TEEVTALRRQVRPMSDKVAGKVTRKL 839
>gi|4758648 kinesin family member 5B [Homo sapiens]
Length = 963
Score = 51.2 bits (121), Expect = 1e-06
Identities = 46/205 (22%), Positives = 104/205 (50%), Gaps = 23/205 (11%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
E ++++E E + +C+ R S + + S T+ ++ VE K++ ++ + +L +L
Sbjct: 617 ESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQN-----VEQKKRQLEESVDALSEEL 671
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
QL+ Q+++ ++++++ +++ A Q +Q++ + +K + D+ V
Sbjct: 672 VQLRA------QEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQ-ISSLRDE-V 723
Query: 145 ELKENLIAELEEK--KKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKP 202
E K LI +L+++ K M+E E+L +E K T + + R + + RR+
Sbjct: 724 EAKAKLITDLQDQNQKMMLEQERLRVE------HEKLKATDQEKSRKLHELTVMQDRREQ 777
Query: 203 APAQLNYLLTDEQIMEDLRTLNKLK 227
A L L +E + ++L+TL+ L+
Sbjct: 778 ARQDLKGL--EETVAKELQTLHNLR 800
>gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens]
Length = 388
Score = 50.4 bits (119), Expect = 2e-06
Identities = 58/237 (24%), Positives = 103/237 (43%), Gaps = 21/237 (8%)
Query: 45 SDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL---QQLQEGTLQEYQKRMKK 101
SD++ ++ E +LAK + VE +EQ K K QL ++ + +Q+Y+K ++
Sbjct: 90 SDDNWKEKIEAELAKERAQHLVEFEEQALLFK-EETKLQLDIEKEKHQDVIQKYKKEQEE 148
Query: 102 LDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKE--FEDKKVELKENLIAELEEK-K 158
L + + I A L+ E ++ K +E ++K++E +NL+AE E + K
Sbjct: 149 LQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNLVAEFESRLK 208
Query: 159 KMIE-----NEKLTMELTGDSMEVKPIM------TRKLRRRPNDPVPIPDKRRKPAPAQL 207
K I+ +E L E+ S E+K +M + + + + + R+ +
Sbjct: 209 KEIDSNDSVSENLRKEMEQKSDELKRVMLAQTQLIEQFNQSQEENTFLQETVRRECEERF 268
Query: 208 NYLLTDEQIMEDLRTLNKLKS--PKRPASPSSPE-HLPATPAESPAQRFEARIEDGK 261
Q E L L+KL+ P P S S PA + +R AR+ K
Sbjct: 269 ELTEALSQAREQLLELSKLRGSLPFSPCSLSKGSLTSPAAAVSNHGERSLARLNSEK 325
Score = 37.7 bits (86), Expect = 0.014
Identities = 37/173 (21%), Positives = 76/173 (43%), Gaps = 8/173 (4%)
Query: 59 KHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRM------KKLDQQYKERIRN 112
K +E+ ++ + + +++L K L Q +E L +R +K +Q +E +R
Sbjct: 27 KEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLISHQKSIEQLQETLRQ 86
Query: 113 AELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKE--NLIAELEEKKKMIENEKLTMEL 170
L E++E KE+ + EFE++ + KE L ++E++K +K E
Sbjct: 87 KLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIEKEKHQDVIQKYKKEQ 146
Query: 171 TGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTL 223
M++ ++T R + + +K K + E+ +E+L+ L
Sbjct: 147 EELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEKEIENLKNL 199
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 49.7 bits (117), Expect = 4e-06
Identities = 40/157 (25%), Positives = 75/157 (47%), Gaps = 13/157 (8%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
EE E E++ R R + +E+ E L K EE+ ++ K A KR
Sbjct: 633 EEVEARRKQEEEARRLRWLQQEEEERRHQEL-LQKKKEEEQERLR------KAAEAKRLA 685
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
+Q ++ ++ ++ ++ +Q+ +E+ R + + + + ER +E+ A +E ++++
Sbjct: 686 EQREQERREQERREQERREQERREQERREQ---ERQLAEQERRREQERLQAERELQEREK 742
Query: 145 EL---KENLIAELEEKKKMIENEKLTMELTGDSMEVK 178
L KE L ELEEKKK E ++L + E K
Sbjct: 743 ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 779
Score = 32.0 bits (71), Expect = 0.77
Identities = 25/106 (23%), Positives = 55/106 (51%), Gaps = 4/106 (3%)
Query: 55 TDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQE-YQKRMKKLDQQYKERIRNA 113
T L + +VE + Q ++ K + +QL+ ++E ++R++++ + +ER+R
Sbjct: 524 TPLRMDPKCSFVEKERQRLEN--LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKV 581
Query: 114 ELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKK 159
L + EQ++ K+ + + ++K + KE +AE + KKK
Sbjct: 582 -LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKK 626
Score = 30.4 bits (67), Expect = 2.3
Identities = 37/174 (21%), Positives = 72/174 (41%), Gaps = 15/174 (8%)
Query: 107 KERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAEL----------EE 156
KER R L + E EQ+ R ++E K + E+ K++ +E L L EE
Sbjct: 537 KERQRLENLRRKEEAEQLRRQKVEEDKR--RRLEEVKLKREERLRKVLQARERVEQMKEE 594
Query: 157 KKKMIENEKLTMELTGDSMEVKPIMTRKLRRR--PNDPVPIPDKRRKPAPA-QLNYLLTD 213
KKK IE + ++ + + + + K +++ + +R++ A +L +L +
Sbjct: 595 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
Query: 214 EQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKR 267
E+ L K K ++ + E +R + R E + ++R
Sbjct: 655 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR 708
Score = 29.3 bits (64), Expect = 5.0
Identities = 39/184 (21%), Positives = 75/184 (40%), Gaps = 31/184 (16%)
Query: 67 EMKEQMYQDKLASLKRQLQQLQEGTLQEYQK---------RMKKLDQQYKERIRNAELFL 117
E EQ+ + K+ KR+ +L+E L+ ++ R++++ ++ K++I +
Sbjct: 549 EEAEQLRRQKVEEDKRR--RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 606
Query: 118 QLETEQVERNYIKE----KKAAVKEFEDKKVELKENLIA----------------ELEEK 157
+TE+ + + E KKAA K+ E+ + K+ A EL +K
Sbjct: 607 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 666
Query: 158 KKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIM 217
KK E E+L + + R+ + R ++R + Q L E+
Sbjct: 667 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 726
Query: 218 EDLR 221
E R
Sbjct: 727 EQER 730
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 49.7 bits (117), Expect = 4e-06
Identities = 40/157 (25%), Positives = 75/157 (47%), Gaps = 13/157 (8%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
EE E E++ R R + +E+ E L K EE+ ++ K A KR
Sbjct: 629 EEVEARRKQEEEARRLRWLQQEEEERRHQEL-LQKKKEEEQERLR------KAAEAKRLA 681
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
+Q ++ ++ ++ ++ +Q+ +E+ R + + + + ER +E+ A +E ++++
Sbjct: 682 EQREQERREQERREQERREQERREQERREQ---ERQLAEQERRREQERLQAERELQEREK 738
Query: 145 EL---KENLIAELEEKKKMIENEKLTMELTGDSMEVK 178
L KE L ELEEKKK E ++L + E K
Sbjct: 739 ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 775
Score = 33.9 bits (76), Expect = 0.20
Identities = 58/295 (19%), Positives = 115/295 (38%), Gaps = 41/295 (13%)
Query: 9 PAPAQAGAPPAPEYYPEE--DEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYV 66
P PA A +P P +E ++ + + +S R + S + SE D +H E++ +
Sbjct: 415 PKPA-ASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQA--VSELDEEQHLEDEEL 471
Query: 67 EMKEQMYQDKLASLKRQLQQLQE--GTLQEYQKRMK-------------------KLDQQ 105
+ + ++ L+ T+Q Q M ++D +
Sbjct: 472 QPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPK 531
Query: 106 YKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAEL----------E 155
KER R L + E EQ+ R ++E K + E+ K++ +E L L E
Sbjct: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKR--RRLEEVKLKREERLRKVLQARERVEQMKE 589
Query: 156 EKKKMIENEKLTMELTGDSMEVKPIMTRKLRRR--PNDPVPIPDKRRKPAPA-QLNYLLT 212
EKKK IE + ++ + + + + K +++ + +R++ A +L +L
Sbjct: 590 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 649
Query: 213 DEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKR 267
+E+ L K K ++ + E +R + R E + ++R
Sbjct: 650 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR 704
>gi|83716024 kinesin family member 21B [Homo sapiens]
Length = 1624
Score = 49.7 bits (117), Expect = 4e-06
Identities = 60/231 (25%), Positives = 107/231 (46%), Gaps = 29/231 (12%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKH---DEEDYVEMKEQMYQDKLASLK 81
E DE E++ER G E +E ED E ++ D + E KE +Q LA L
Sbjct: 581 ETDENEAEEEEEERDESGCEEEEGREDEDEDSGSEESLVDSDSDPEEKEVNFQADLADLT 640
Query: 82 RQLQQLQE--GTLQEYQKRMKKLDQQYKER---IRNAELFLQLETEQVERN------YIK 130
+++ Q+ L+ Q+R++ L QY+E+ ++N QLE ++V +N Y +
Sbjct: 641 CEIEIKQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLERDRVLQNLSTMECYTE 700
Query: 131 EKKAAVK-EFEDKKVELK---ENLIAELEEKKKMIEN----EKLTMELTGDSMEVK--PI 180
EK +K ++E + E+ + L A +E ++++N E+ +L + E+K +
Sbjct: 701 EKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYERELKKLQAEVAEMKKAKV 760
Query: 181 MTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKR 231
K R + + +R AQL EQ ++ + + L+S KR
Sbjct: 761 ALMKQMREEQQRRRLVETKRNREIAQLK----KEQRRQEFQ-IRALESQKR 806
>gi|221219026 pleckstrin homology-like domain, family B, member 1
isoform b [Homo sapiens]
Length = 1319
Score = 49.3 bits (116), Expect = 5e-06
Identities = 40/138 (28%), Positives = 77/138 (55%), Gaps = 11/138 (7%)
Query: 45 SDEDT--EDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKL 102
SDE+ E+ S T+ + + ED K Q ++ +L+ + Q+ G +++ + R+K+L
Sbjct: 682 SDEENLKEECSSTESTQQEHEDAPSTK---LQGEVLALEEERAQVL-GHVEQLKVRVKEL 737
Query: 103 DQQYKERIRNAEL---FLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKK 159
+QQ +E R AE+ LQ E E ER +++++ AV + ++K V L+ + E +++ +
Sbjct: 738 EQQLQESAREAEMERALLQGERE-AERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE 796
Query: 160 MIENE-KLTMELTGDSME 176
+E E KL +L +E
Sbjct: 797 ALETETKLFEDLEFQQLE 814
Score = 30.4 bits (67), Expect = 2.3
Identities = 73/321 (22%), Positives = 119/321 (37%), Gaps = 87/321 (27%)
Query: 26 EDEELESAEDDERSCRGRES-DEDTEDASETDLAK--------------HDEEDYVEMKE 70
E E E+ + C ES ++ EDA T L H E+ V +KE
Sbjct: 677 ESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKE 736
Query: 71 --QMYQDKL--ASLKRQLQQ----LQEGTLQEYQKRMKKLDQQY--------KERIRNAE 114
Q Q+ A ++R L Q + LQ+ QK + +L ++ KER + AE
Sbjct: 737 LEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE 796
Query: 115 -------LFLQLETEQVER-----------------------NYIKEKKAAVKEFEDKKV 144
LF LE +Q+ER I ++K + + +
Sbjct: 797 ALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAG 856
Query: 145 ELKENLIAELE---------------EKKKMIENEKLTMELTGDSMEVKPIMT-RKLRRR 188
+++ + E E EK+K+ E+ LTG K T +++ R
Sbjct: 857 QIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRS 916
Query: 189 PND---PVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPK-----RPASPSSPEH 240
D P+P R P P+ + Q+ + TL + SPK + + S P +
Sbjct: 917 KMDGEATSPLPRTRSGPLPSSSGSSSSSSQL--SVATLGRSPSPKSALLTQNGTGSLPRN 974
Query: 241 LPATPAESPAQRFEARIEDGK 261
L AT + +R A + G+
Sbjct: 975 LAATLQDIETKRQLALQQKGQ 995
Score = 29.3 bits (64), Expect = 5.0
Identities = 24/94 (25%), Positives = 45/94 (47%), Gaps = 13/94 (13%)
Query: 45 SDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQ 104
S ++ AS D+ K +E E+M ++ A R L E +E + R + L++
Sbjct: 1086 SPDNMSSASGLDMGK------IEEMEKMLKEAHAEKNR----LMESREREMELRRQALEE 1135
Query: 105 QYKERIRNAELFLQLETEQVERNYIKEKKAAVKE 138
ER R ++ +L++E R + EK+ ++E
Sbjct: 1136 ---ERRRREQVERRLQSESARRQQLVEKEVKMRE 1166
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 49.3 bits (116), Expect = 5e-06
Identities = 40/138 (28%), Positives = 77/138 (55%), Gaps = 11/138 (7%)
Query: 45 SDEDT--EDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKL 102
SDE+ E+ S T+ + + ED K Q ++ +L+ + Q+ G +++ + R+K+L
Sbjct: 682 SDEENLKEECSSTESTQQEHEDAPSTK---LQGEVLALEEERAQVL-GHVEQLKVRVKEL 737
Query: 103 DQQYKERIRNAEL---FLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKK 159
+QQ +E R AE+ LQ E E ER +++++ AV + ++K V L+ + E +++ +
Sbjct: 738 EQQLQESAREAEMERALLQGERE-AERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE 796
Query: 160 MIENE-KLTMELTGDSME 176
+E E KL +L +E
Sbjct: 797 ALETETKLFEDLEFQQLE 814
Score = 29.6 bits (65), Expect = 3.8
Identities = 47/179 (26%), Positives = 78/179 (43%), Gaps = 41/179 (22%)
Query: 26 EDEELESAEDDERSCRGRES-DEDTEDASETDLAK--------------HDEEDYVEMKE 70
E E E+ + C ES ++ EDA T L H E+ V +KE
Sbjct: 677 ESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKE 736
Query: 71 --QMYQDKL--ASLKRQLQQ----LQEGTLQEYQKRMKKLDQQY--------KERIRNAE 114
Q Q+ A ++R L Q + LQ+ QK + +L ++ KER + AE
Sbjct: 737 LEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE 796
Query: 115 -------LFLQLETEQVER--NYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENE 164
LF LE +Q+ER +E++ A + K EL + IA+ +E+ +++++
Sbjct: 797 ALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS-IAKRKERLAILDSQ 854
Score = 29.3 bits (64), Expect = 5.0
Identities = 24/94 (25%), Positives = 45/94 (47%), Gaps = 13/94 (13%)
Query: 45 SDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQ 104
S ++ AS D+ K +E E+M ++ A R L E +E + R + L++
Sbjct: 1133 SPDNMSSASGLDMGK------IEEMEKMLKEAHAEKNR----LMESREREMELRRQALEE 1182
Query: 105 QYKERIRNAELFLQLETEQVERNYIKEKKAAVKE 138
ER R ++ +L++E R + EK+ ++E
Sbjct: 1183 ---ERRRREQVERRLQSESARRQQLVEKEVKMRE 1213
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 49.3 bits (116), Expect = 5e-06
Identities = 40/138 (28%), Positives = 77/138 (55%), Gaps = 11/138 (7%)
Query: 45 SDEDT--EDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKL 102
SDE+ E+ S T+ + + ED K Q ++ +L+ + Q+ G +++ + R+K+L
Sbjct: 682 SDEENLKEECSSTESTQQEHEDAPSTK---LQGEVLALEEERAQVL-GHVEQLKVRVKEL 737
Query: 103 DQQYKERIRNAEL---FLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKK 159
+QQ +E R AE+ LQ E E ER +++++ AV + ++K V L+ + E +++ +
Sbjct: 738 EQQLQESAREAEMERALLQGERE-AERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE 796
Query: 160 MIENE-KLTMELTGDSME 176
+E E KL +L +E
Sbjct: 797 ALETETKLFEDLEFQQLE 814
Score = 29.6 bits (65), Expect = 3.8
Identities = 47/179 (26%), Positives = 78/179 (43%), Gaps = 41/179 (22%)
Query: 26 EDEELESAEDDERSCRGRES-DEDTEDASETDLAK--------------HDEEDYVEMKE 70
E E E+ + C ES ++ EDA T L H E+ V +KE
Sbjct: 677 ESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKE 736
Query: 71 --QMYQDKL--ASLKRQLQQ----LQEGTLQEYQKRMKKLDQQY--------KERIRNAE 114
Q Q+ A ++R L Q + LQ+ QK + +L ++ KER + AE
Sbjct: 737 LEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAE 796
Query: 115 -------LFLQLETEQVER--NYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENE 164
LF LE +Q+ER +E++ A + K EL + IA+ +E+ +++++
Sbjct: 797 ALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS-IAKRKERLAILDSQ 854
Score = 29.3 bits (64), Expect = 5.0
Identities = 24/94 (25%), Positives = 45/94 (47%), Gaps = 13/94 (13%)
Query: 45 SDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQ 104
S ++ AS D+ K +E E+M ++ A R L E +E + R + L++
Sbjct: 1133 SPDNMSSASGLDMGK------IEEMEKMLKEAHAEKNR----LMESREREMELRRQALEE 1182
Query: 105 QYKERIRNAELFLQLETEQVERNYIKEKKAAVKE 138
ER R ++ +L++E R + EK+ ++E
Sbjct: 1183 ---ERRRREQVERRLQSESARRQQLVEKEVKMRE 1213
>gi|59806361 hypothetical protein LOC387104 [Homo sapiens]
Length = 947
Score = 48.9 bits (115), Expect = 6e-06
Identities = 47/216 (21%), Positives = 101/216 (46%), Gaps = 28/216 (12%)
Query: 2 SAAGLLAPAPAQAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHD 61
SA G + QA APP+ + +P++ +E E +++ R +E+ +E D + +
Sbjct: 321 SAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEMEKLR----EENETLKNEIDELRTE 376
Query: 62 EEDYVEMKEQMYQDKLASLKRQLQQLQEG--TLQEYQKRMKKLDQQYKERIRNAELFLQL 119
+ EM++ +++ L+ +L+ + Q R++K + ++R+R A
Sbjct: 377 MD---EMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAE---RKRLRYA------ 424
Query: 120 ETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMI--ENEKLTMELTGDSM-- 175
+T +++ ++ + +K +D V L L +EEK+ ENEKL +L +
Sbjct: 425 QTGEIDGELLRSLEQDLKVAKDVSVRLHHEL-ENVEEKRTTTEDENEKLRQQLIEVEIAK 483
Query: 176 -----EVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQ 206
E++ + L+RR + +P +K+ + P +
Sbjct: 484 QALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 48.1 bits (113), Expect = 1e-05
Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 23/172 (13%)
Query: 19 APEYYPEEDEELESAEDDERSCRGR--ESDEDTEDASETDLAKHDEEDYVEMKEQMYQDK 76
A E E E+L++ ED R + E++E E E ++ E +++ KEQ Y++K
Sbjct: 665 AKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEK 724
Query: 77 LASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAV 136
+ L Q+ K D KE + N + + E E E+ I ++ A+
Sbjct: 725 IKVLDNQI----------------KKDLADKETLEN--MMQRHEEEAHEKGKILSEQKAM 766
Query: 137 KEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRR 188
D K+ E I EL E K+ N L T +M+ + M +LR++
Sbjct: 767 INAMDSKIRSLEQRIVELSEANKLAANSSL---FTQRNMKAQEEMISELRQQ 815
Score = 37.0 bits (84), Expect = 0.024
Identities = 42/168 (25%), Positives = 73/168 (43%), Gaps = 8/168 (4%)
Query: 29 ELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQ 88
E S + R S ED + + E+KEQ YQ ++ ++ + QL+
Sbjct: 513 ECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLE 572
Query: 89 EGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEK---KAAVKEFED-KKV 144
E L ++R + + +E AE F + TE + +K K K V E+ +K+
Sbjct: 573 E-DLVSARRRSDLYESELRESRLAAEEFKRKATE-CQHKLLKAKDQGKPEVGEYAKLEKI 630
Query: 145 ELKENL-IAELEEK-KKMIENEKLTMELTGDSMEVKPIMTRKLRRRPN 190
++ L I EL+EK +K ++ EL + + K R+L + N
Sbjct: 631 NAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQN 678
Score = 35.0 bits (79), Expect = 0.091
Identities = 30/111 (27%), Positives = 53/111 (47%), Gaps = 6/111 (5%)
Query: 58 AKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKL----DQQYK-ERIRN 112
A + +E Y + +SLKR L+Q + QE K ++ L +Q K + I+
Sbjct: 495 ASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKE 554
Query: 113 AELFLQLETEQVERNYIKEKKAAVKEFED-KKVELKENLIAELEEKKKMIE 162
E Q+E ++ N ++E + + D + EL+E+ +A E K+K E
Sbjct: 555 QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATE 605
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 47.8 bits (112), Expect = 1e-05
Identities = 49/195 (25%), Positives = 90/195 (46%), Gaps = 16/195 (8%)
Query: 20 PEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLAS 79
P + + +L + E +R R +E+ E + E ++E +EQ+ + + A
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA- 846
Query: 80 LKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEF 139
+QLQ+ ++G LQE Q+R + +Q+ ++ R QLE E+ R + K A++E
Sbjct: 847 --QQLQEEEDG-LQEDQERRRSQEQRRDQKWR-----WQLEEERKRRRHTLYAKPALQEQ 898
Query: 140 EDKKVEL----KENLIAELEEKKKMIENEKLTMELTGDSMEVKPIM---TRKLRRRPNDP 192
K+ +L +E L E EK++ E E+ E E + ++ K RR+ +
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 193 VPIPDKRRKPAPAQL 207
DK+ + QL
Sbjct: 959 QYRKDKKLQQKEEQL 973
Score = 46.2 bits (108), Expect = 4e-05
Identities = 47/172 (27%), Positives = 86/172 (50%), Gaps = 14/172 (8%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
EE+EEL+ E ++R R +++ + E L + +E+ E +E+ + + R+
Sbjct: 908 EEEEELQREEREKR----RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFE---D 141
++LQ+ Q + +K +Q +E+ E LQ E EQ+ R + +K +E+E
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE--EREKRRRQEWERQYR 1021
Query: 142 KKVEL---KENLIAELEEKKKMIENEKLTMELTGDSMEVKPIM--TRKLRRR 188
KK EL +E L+ E EK+++ E E+ E E + ++ R+ RRR
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073
Score = 45.4 bits (106), Expect = 7e-05
Identities = 40/169 (23%), Positives = 86/169 (50%), Gaps = 19/169 (11%)
Query: 25 EEDEELESAEDDERSCRGR-ESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQ 83
+ED+E +++ R + R + +E+ + T AK ++ + ++Q+ Q++ L+R+
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916
Query: 84 LQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFE--- 140
++ ++R ++ ++QY+E E LQ E EQ+ R ++++ +E +
Sbjct: 917 ERE---------KRRRQEQERQYRE-----EEQLQQEEEQLLREEREKRRRQERERQYRK 962
Query: 141 DKKVELK-ENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRR 188
DKK++ K E L+ E EK++ E EK E E + ++ + +R
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Score = 44.7 bits (104), Expect = 1e-04
Identities = 35/168 (20%), Positives = 75/168 (44%), Gaps = 10/168 (5%)
Query: 21 EYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASL 80
E P + + E + G E E E + D + DEE + + +E +++ +
Sbjct: 130 EEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAE 189
Query: 81 KRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELF-LQLETEQVERNYIKEKKAAVKEF 139
+ QLQ + +E+ +E++R EL L+ + + ++ +E++ V +
Sbjct: 190 EEQLQSCKGHETEEFPD---------EEQLRRRELLELRRKGREEKQQQRRERQDRVFQE 240
Query: 140 EDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRR 187
E++K K + EE+K E + EL + +++ + ++LRR
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRR 288
Score = 44.7 bits (104), Expect = 1e-04
Identities = 50/208 (24%), Positives = 99/208 (47%), Gaps = 29/208 (13%)
Query: 26 EDEELESAED----DERSCRGRESDE-------DTEDASETDLAKHDEEDYVEMKEQMYQ 74
E+EEL+ E+ +ER R R+ E + + E L + E+ ++ +E+ Y+
Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYR 1051
Query: 75 DKLASLKRQLQQLQEGTLQEYQ--KRMKKLDQQYKERIRNAELFLQLETEQV-----ERN 127
++ +LQQ +E L E + +R ++L++QY++ E LQ E EQ+ E+
Sbjct: 1052 EE-----EELQQEEEQLLGEERETRRRQELERQYRK-----EEELQQEEEQLLREEPEKR 1101
Query: 128 YIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRR 187
+E++ +E E+ + E +E L+ E EK++ E E+ E E + ++ + +
Sbjct: 1102 RRQERERQCREEEELQQE-EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK 1160
Query: 188 RPNDPVPIPDKRRKPAPAQLNYLLTDEQ 215
R + + + + LL +EQ
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQ 1188
Score = 43.1 bits (100), Expect = 3e-04
Identities = 36/166 (21%), Positives = 78/166 (46%), Gaps = 12/166 (7%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTED--ASETDLAKHDEEDYVEMKEQMYQDKLASLKR 82
EE+ + E + R R + E+ D E + +H++E K+Q+ +D+ +
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE---RRKQQLKRDQEEERRE 486
Query: 83 QLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDK 142
+ +L+E +E Q+R ++ ++ +E R L Q E E++++ E ++ +
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE-----QQLRRE 541
Query: 143 KVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRR 188
+ E +E L+ EEK+ +E E+ L + E + + ++ R
Sbjct: 542 QEERREQLLKREEEKR--LEQERREQRLKREQEERRDQLLKREEER 585
Score = 42.7 bits (99), Expect = 4e-04
Identities = 45/201 (22%), Positives = 91/201 (45%), Gaps = 6/201 (2%)
Query: 21 EYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASL 80
E +P+E E+L E E +GRE + + + + +EE +E + + + L
Sbjct: 202 EEFPDE-EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL 260
Query: 81 KRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQ--LETEQVERNYIKEKKAAVKE 138
+ + Q Q LQE +++++KL++Q R R E Q L EQ R +E++ +E
Sbjct: 261 QEEEPQRQR-ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 139 FEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDK 198
++ E +E E++ + + E+ +L + E + ++LRR +
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEER--REQQLRREQEEERREQQL 377
Query: 199 RRKPAPAQLNYLLTDEQIMED 219
RR+ + L ++Q+ +
Sbjct: 378 RREQQLRREQQLRREQQLRRE 398
Score = 42.7 bits (99), Expect = 4e-04
Identities = 42/169 (24%), Positives = 82/169 (48%), Gaps = 10/169 (5%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
+E+E+L E ++R + RE E+ +L + +E+ E +E + +L R+
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEE----ELQQEEEQLLGEERETRRRQELERQYRKE 1083
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQV-----ERNYIKEKKAAVKEF 139
++LQ+ Q ++ +K +Q +ER E LQ E EQ+ E+ +E + +E
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 140 EDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRR 188
E+ + E +E L+ E EK++ E E+ E E + ++ + +R
Sbjct: 1144 EEVQQE-EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191
Score = 42.7 bits (99), Expect = 4e-04
Identities = 37/164 (22%), Positives = 78/164 (47%), Gaps = 22/164 (13%)
Query: 22 YYPEEDEELESAEDDERSCRGRESDEDTE----------DASETDLAKHDEEDYVEMKEQ 71
++PEE E+LE E E R R+S E+ + ETD +EE ++ +E+
Sbjct: 1292 HFPEE-EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE 1350
Query: 72 -----MYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYK-----ERIRNAELFLQLET 121
+D+ + Q Q E ++R+++ +++ K +++R E QL
Sbjct: 1351 QPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ 1410
Query: 122 EQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEK 165
++ +R + +E++ ++ D+K +E + E ++K +E E+
Sbjct: 1411 DR-DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ 1453
Score = 39.7 bits (91), Expect = 0.004
Identities = 42/177 (23%), Positives = 79/177 (44%), Gaps = 18/177 (10%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
+E+E E + ER RE E D K +EE E EQ +R+
Sbjct: 429 QEEERHEQKHEQER----REQRLKREQEERRDWLKREEE--TERHEQ---------ERRK 473
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
QQL+ +E ++R KL+++ + R + QL EQ ER + K+ +E +++
Sbjct: 474 QQLKRDQEEERRERWLKLEEE-ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 145 ELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRK 201
++ L E EE+++ + + L + E + + R+ R + + ++RR+
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQR--LKREQEERRDQLLKREEERRQ 587
Score = 38.9 bits (89), Expect = 0.006
Identities = 28/146 (19%), Positives = 70/146 (47%), Gaps = 3/146 (2%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEM---KEQMYQDKLASLK 81
EE E + + + R ++ + E+ E L + EE+ E +EQ + + L+
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 82 RQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFED 141
R+ Q +E L+ Q+ ++ + ++++R + + + + E+ +E++ E +
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 142 KKVELKENLIAELEEKKKMIENEKLT 167
++ ++ L E EE++ ++ E+ T
Sbjct: 439 EQERREQRLKREQEERRDWLKREEET 464
Score = 38.9 bits (89), Expect = 0.006
Identities = 37/142 (26%), Positives = 70/142 (49%), Gaps = 20/142 (14%)
Query: 28 EELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQL 87
EE E E ER R ++ + E+ E L + +EE+ ++ + + Q L+R+ ++
Sbjct: 492 EEEERREQQER--REQQLRREQEERREQRLKRQEEEERLQQRLRSEQ----QLRREQEER 545
Query: 88 QEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELK 147
+E L+ ++ K+L+Q+ +E+ +L+ EQ ER + +E E ++ LK
Sbjct: 546 REQLLKREEE--KRLEQERREQ--------RLKREQEER----RDQLLKREEERRQQRLK 591
Query: 148 ENLIAELEEKKKMIENEKLTME 169
LE++ K E E+L E
Sbjct: 592 REQEERLEQRLKREEVERLEQE 613
Score = 38.9 bits (89), Expect = 0.006
Identities = 35/165 (21%), Positives = 79/165 (47%), Gaps = 20/165 (12%)
Query: 26 EDEELESAEDD----ERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLK 81
E+++L E D E + R + D + + ++ E ++E ++Q+++ +
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ----- 1528
Query: 82 RQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFED 141
RQ + LQE ++ +R ++ Q+ ++R R QL E+ E+ ++++ D
Sbjct: 1529 RQRKFLQE---EQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER-------D 1578
Query: 142 KKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLR 186
+K L+E + E+++K +E+E+ G +++ RK R
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEG-QQQLRQERDRKFR 1622
Score = 37.7 bits (86), Expect = 0.014
Identities = 31/158 (19%), Positives = 75/158 (47%), Gaps = 3/158 (1%)
Query: 13 QAGAPPAPEYYPEEDEELESAEDDE-RSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQ 71
Q P EE+E+L E E R R E + E L + EE+ E +E+
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 72 MYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKE 131
+ + +++ ++ Q+ ++ ++R ++L ++ +E R +L + E E+ E+ +E
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380
Query: 132 KKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTME 169
++ ++ ++ +L+ +L ++++ ++L E
Sbjct: 381 QQLRREQQLRREQQLRRE--QQLRREQQLRREQQLRRE 416
Score = 37.7 bits (86), Expect = 0.014
Identities = 34/154 (22%), Positives = 69/154 (44%), Gaps = 14/154 (9%)
Query: 26 EDEELESAEDDERSCRGRESDEDTEDA-----------SETDLAKHDEEDYVEMKEQMYQ 74
E+ E ++ ER CR E + E+ E + +EE+ + +EQ+ +
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 75 DKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKA 134
++ +RQ + Q +E Q+ ++L ++ +E+ R E E+++R K++
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 135 AVKEFEDKKVEL---KENLIAELEEKKKMIENEK 165
+ D K + KEN + + + K ENE+
Sbjct: 1216 DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQ 1249
Score = 37.7 bits (86), Expect = 0.014
Identities = 33/144 (22%), Positives = 66/144 (45%), Gaps = 14/144 (9%)
Query: 26 EDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQ 85
++ E + ER + E + +HD + +EQ+ Q+ + Q
Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE------GEEQ 1682
Query: 86 QLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVE 145
QL+ QE ++ ++ +QQ + + R + FLQ E +Q+ R ++ K +E E + E
Sbjct: 1683 QLRR---QERDRKFREEEQQLRRQERERK-FLQ-EEQQLRRQELERK---FREEEQLRQE 1734
Query: 146 LKENLIAELEEKKKMIENEKLTME 169
++ + E +K++E E+L E
Sbjct: 1735 TEQEQLRRQERYRKILEEEQLRPE 1758
Score = 37.0 bits (84), Expect = 0.024
Identities = 33/150 (22%), Positives = 73/150 (48%), Gaps = 21/150 (14%)
Query: 23 YPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKR 82
+ EE++ L+ E +E+ R +E D + + + E +++ ++Q+ + +L R
Sbjct: 1669 FREEEQLLQ--EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFR 1726
Query: 83 QLQQLQEGT--------------LQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNY 128
+ +QL++ T L+E Q R ++ +QQ + + R+ + E EQ+ +
Sbjct: 1727 EEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF---REEEQLRQE- 1782
Query: 129 IKEKKAAVKEFEDKKVELKENLIAELEEKK 158
+E++ + D+K +E L E EE++
Sbjct: 1783 -REEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Score = 36.2 bits (82), Expect = 0.041
Identities = 49/233 (21%), Positives = 97/233 (41%), Gaps = 38/233 (16%)
Query: 21 EYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEED--------YVEMKEQM 72
E EE++ L ++ R R R+ E+ E + ++ +ED + KE
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA 1234
Query: 73 YQDKLASLK----RQLQQLQEGTLQEYQKRMKKL----DQQYKERIRNAELFLQL----- 119
+D K Q +QL++ L++ Q + +QQ ++R + + Q
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFP 1294
Query: 120 ETEQVERNYIKEKKAAVKEFEDKKVELKENLIAEL-EEKKKMIENEKLTMELTGDSMEVK 178
E EQ+ER KE K D+K + ++ L+ E EEK++ E ++ E
Sbjct: 1295 EEEQLEREEQKEAKR-----RDRKSQEEKQLLREEREEKRRRQETDRKFRE--------- 1340
Query: 179 PIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKR 231
+ L+ R P+ ++ RK +L + + +E+ + L + + ++
Sbjct: 1341 --EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391
Score = 35.4 bits (80), Expect = 0.070
Identities = 30/141 (21%), Positives = 64/141 (45%), Gaps = 11/141 (7%)
Query: 35 DDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQE 94
+DE+ R +E + E D ++E ++ +E+ +L +R + L+E
Sbjct: 1599 EDEQQLRRQEGQQQLRQ--ERDRKFREDEQLLQEREEQ---QLHRQERDRKFLEEEPQLR 1653
Query: 95 YQKRMKKLDQQYKERIRNAELFL------QLETEQVERNYIKEKKAAVKEFEDKKVELKE 148
Q+R ++L + R E L QL ++ +R + +E++ ++ ++K +E
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEE 1713
Query: 149 NLIAELEEKKKMIENEKLTME 169
+ E ++K E E+L E
Sbjct: 1714 QQLRRQELERKFREEEQLRQE 1734
Score = 33.9 bits (76), Expect = 0.20
Identities = 36/155 (23%), Positives = 69/155 (44%), Gaps = 16/155 (10%)
Query: 26 EDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQ 85
++ E E ER + E ++ + E L + + + +EQ+ Q++ R Q
Sbjct: 1733 QETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS-Q 1791
Query: 86 QLQEGTLQEYQKRMKKLDQQYKERIRNA-----ELFLQLETEQV------ERNYIKEKKA 134
+ +E Q R ++ +QQ + + R+ E LQLE ++ +R Y E++
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851
Query: 135 AVKEFEDKKVELKENLIAELEEKKKMIENEKLTME 169
A +E K +E + + EE+K+ E E+ E
Sbjct: 1852 ATQE----KSRREEQELWQEEEQKRRQERERKLRE 1882
Score = 33.5 bits (75), Expect = 0.27
Identities = 37/161 (22%), Positives = 80/161 (49%), Gaps = 23/161 (14%)
Query: 25 EEDEELESAEDDERSCRGRESDEDT----EDASETDLAKHDEEDYVEMK------EQMYQ 74
EE++ LE ++R R +E D E+ K ++E+ +E + E++ Q
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ 612
Query: 75 DKLAS--LKRQ------LQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVER 126
++ LKR+ QQL + QE ++R ++L ++ +ER R L + E E++E+
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQE-ERRQQQLRREQQER-REQRLKREEEEERLEQ 670
Query: 127 NYIKEKKAAVKE---FEDKKVELKENLIAELEEKKKMIENE 164
+E + +E E+++ + +E + + + + + +E+E
Sbjct: 671 RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESE 711
Score = 32.7 bits (73), Expect = 0.45
Identities = 39/197 (19%), Positives = 92/197 (46%), Gaps = 14/197 (7%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
EE E + + E R ++ + + E L + E + ++Q+ +++ ++QL
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRR---EQQLRREQQLRREQQLRREQQL 413
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVER-NYIK-EKKAAVKEFEDK 142
++ Q+ +E Q R ++ +++++++ +L+ EQ ER +++K E++ E E +
Sbjct: 414 RREQQ-LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 143 KVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKP 202
K +LK + E E+ +E E + E + ++LRR + KR++
Sbjct: 473 KQQLKRDQEEERRERWLKLEEE--------ERREQQERREQQLRREQEERREQRLKRQEE 524
Query: 203 APAQLNYLLTDEQIMED 219
L +++Q+ +
Sbjct: 525 EERLQQRLRSEQQLRRE 541
Score = 31.6 bits (70), Expect = 1.0
Identities = 24/143 (16%), Positives = 67/143 (46%), Gaps = 6/143 (4%)
Query: 24 PEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQ 83
P + E ++ E R RES+ ++ + +EE + Q ++ + RQ
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 84 LQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKK 143
+ ++ +++++ ++Q +E + FL E E+ +R + ++ +F +++
Sbjct: 783 RLSARPPLREQRERQLRAEERQQRE-----QRFLPEEEEKEQRRRQRREREKELQFLEEE 837
Query: 144 VELKENLIA-ELEEKKKMIENEK 165
+L+ A +L+E++ ++ ++
Sbjct: 838 EQLQRRERAQQLQEEEDGLQEDQ 860
>gi|94721321 coiled-coil domain containing 11 [Homo sapiens]
Length = 514
Score = 47.4 bits (111), Expect = 2e-05
Identities = 44/172 (25%), Positives = 78/172 (45%), Gaps = 14/172 (8%)
Query: 59 KHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKR----MKKLDQQYKERIRNAE 114
KH+ E + K++ Q+ L++ LQ+ E QEY+ MK + + ++ A+
Sbjct: 267 KHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEAD 326
Query: 115 LFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEK-LTMELTGD 173
Q + + I K A + E+K E + + I E ++ KK+ E +K L +E
Sbjct: 327 KKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEAR 386
Query: 174 SMEVKPIM-TRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLN 224
V +M TRKL+ + +K ++ A Q + + I E L+ LN
Sbjct: 387 RQLVDEVMCTRKLQ--------VQEKLQREAKEQEERAMEQKHINESLKELN 430
Score = 29.3 bits (64), Expect = 5.0
Identities = 23/94 (24%), Positives = 49/94 (52%), Gaps = 8/94 (8%)
Query: 82 RQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFED 141
R+L L+E + K+ ++ K+R+R L+ + E+ ++++ EK ++F +
Sbjct: 102 RELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEK--LDQQFRE 159
Query: 142 KKVELKENLIA-----ELEEKKKMIE-NEKLTME 169
+ EL+ L++ EE+K I NE+L+ +
Sbjct: 160 RCEELRVELLSIHQKKVCEERKAQIAFNEELSRQ 193
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 47.4 bits (111), Expect = 2e-05
Identities = 38/167 (22%), Positives = 89/167 (53%), Gaps = 13/167 (7%)
Query: 11 PAQAGAPPAPEYYPEEDE--------ELESAEDDERSCRGRESDE----DTEDASETDLA 58
P + G P+ + +EDE + E + ER+ + RE +E + A+ +
Sbjct: 426 PGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKL 485
Query: 59 KHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQ 118
K +E +++Q +++ +R+ ++ +E L++ Q++ ++ +++ K+R R E +
Sbjct: 486 KRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKERE-KDRERQQEKEKE 544
Query: 119 LETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEK 165
LE EQ ++ +++++ KE E ++ + KE + +++E++K E EK
Sbjct: 545 LEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEK 591
Score = 45.4 bits (106), Expect = 7e-05
Identities = 34/126 (26%), Positives = 66/126 (52%), Gaps = 7/126 (5%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
E ++ELE ++ ER + RE D + + E +L K E+ EM+++ Q+K L+RQ
Sbjct: 514 EREKELEKEQEQERE-KEREKDRERQQEKEKELEKEQEKQR-EMEKERKQEKEKELERQK 571
Query: 85 Q---QLQEGTLQEYQKRMKKLDQQYKERI--RNAELFLQLETEQVERNYIKEKKAAVKEF 139
+ +LQ+ QE + ++K ++ +E+I R L +E ++ E + KE++
Sbjct: 572 EKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQ 631
Query: 140 EDKKVE 145
+ + E
Sbjct: 632 DSNRSE 637
Score = 42.7 bits (99), Expect = 4e-04
Identities = 51/196 (26%), Positives = 88/196 (44%), Gaps = 37/196 (18%)
Query: 27 DEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQ 86
DE+L E RE + + E E +L K E++ + +E+ R+ QQ
Sbjct: 489 DEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREK---------DRERQQ 539
Query: 87 LQEGTL---QEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKK 143
+E L QE Q+ M+K +Q KE+ ++ER KEK+ + ++K+
Sbjct: 540 EKEKELEKEQEKQREMEKERKQEKEK-------------ELERQKEKEKELQKMKEQEKE 586
Query: 144 VEL---KENLIAELEEKKKMIEN--EKLTMELTGDSMEVKPIMTRK-LRRRPNDPVPI-- 195
EL +E L ++E ++ +E EK E + E +P+ TR+ R + P+
Sbjct: 587 CELEKEREKLEEKIEPREPNLEPMVEKQESE-NSCNKEEEPVFTRQDSNRSEKEATPVVH 645
Query: 196 ---PDKRRKPAPAQLN 208
P+ +P PA L+
Sbjct: 646 ETEPESGSQPRPAVLS 661
Score = 29.6 bits (65), Expect = 3.8
Identities = 32/127 (25%), Positives = 51/127 (40%), Gaps = 26/127 (20%)
Query: 137 KEFEDKKVE----LKENLIAEL-EEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPND 191
+E D+ V +K+ ++ ++ EE+++ E E E + + VKP T K P
Sbjct: 1003 EEVNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEKAEKVTEKVVVKPEKTEKKDLPPPP 1062
Query: 192 PVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQ 251
P P P PAP Q + P +P + P AT A+ P+Q
Sbjct: 1063 PPPQP-----PAPIQ----------------PQSVPPPIQPEAEKFPSTETATLAQKPSQ 1101
Query: 252 RFEARIE 258
E +E
Sbjct: 1102 DTEKPLE 1108
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 47.0 bits (110), Expect = 2e-05
Identities = 46/203 (22%), Positives = 100/203 (49%), Gaps = 14/203 (6%)
Query: 27 DEELESAEDDERSCRGRE--SDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
+E+ + AE++E RE S+E+T+ A E +L ++E + KE+M +++ L R+
Sbjct: 1744 EEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEE-ERLGRKR 1802
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
+QL E ++ QKR + ++ +E +N + Q ++N +EKK +E ++K
Sbjct: 1803 EQLIEKKMKLAQKRERWINSM-EELTKNKMILYQ------KKNLAQEKKNLAQE-KEKLA 1854
Query: 145 ELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAP 204
+ KENL L K+++ ++K +++ I+ + + + + K+ K A
Sbjct: 1855 QRKENL---LYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAE 1911
Query: 205 AQLNYLLTDEQIMEDLRTLNKLK 227
+ + ++ + + L + K
Sbjct: 1912 TEKKLVQVEDSLAKKQEKLAQEK 1934
Score = 46.6 bits (109), Expect = 3e-05
Identities = 48/227 (21%), Positives = 102/227 (44%), Gaps = 13/227 (5%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
EE+E E E +E R E + E+ E + +EE+ + K++ ++++ +
Sbjct: 2247 EEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVF 2306
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
++ +E +E + + D++ +E + E + E E ++ KEK+ ++E K +
Sbjct: 2307 EEKEEIMSEEETESLS--DEEEEEESCSLEEEVDREKEILK----KEKQFKLQEQRRKSL 2360
Query: 145 ELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAP 204
+E +++ L + + + + L +K +M+ L + PVP+P+K+
Sbjct: 2361 RGRERVLSIL---RGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWED 2417
Query: 205 AQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQ 251
+ + E + L T++K + P P H+ T ES AQ
Sbjct: 2418 KKATVV---EIPRKFLGTMDKEREVMGKYEP-IPPHVLGTVLESQAQ 2460
Score = 42.0 bits (97), Expect = 7e-04
Identities = 54/248 (21%), Positives = 107/248 (43%), Gaps = 33/248 (13%)
Query: 26 EDEELESAEDDE------RSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLAS 79
+DEE E++E R R R+ + + E ++ DE + E+ + +++ S
Sbjct: 2177 DDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVE----SEEHFSEEMES 2232
Query: 80 LKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEF 139
L +L++ QE E ++ ++ +++ +E +R E E+ + E+K KE
Sbjct: 2233 LLDELEK-QESLSSEEEEEREEEEEREEEEVREEE-------EERKEEEEGEEKQVEKEE 2284
Query: 140 EDKKVELKENLIAELEEKKKMIENEKLTM-----ELTGDSMEVKPIMTRKLRRRPNDPVP 194
E+KK + KE E++EK+++ E ++ M E D E + + + +
Sbjct: 2285 EEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEIL 2344
Query: 195 IPDKRRKPAPAQLNYLLTDEQIMEDLR----------TLNKLKSPKRPASPSSPEHLPAT 244
+K+ K + L E+++ LR L LKSP + ++ E T
Sbjct: 2345 KKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKT 2404
Query: 245 PAESPAQR 252
P P ++
Sbjct: 2405 PVPVPEKQ 2412
Score = 36.6 bits (83), Expect = 0.031
Identities = 67/290 (23%), Positives = 122/290 (42%), Gaps = 39/290 (13%)
Query: 21 EYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQD--KLA 78
E +E+ +L E + + +D E A EE + E++ Q+ KLA
Sbjct: 1600 EKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLA 1659
Query: 79 SLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKE 138
+++L + E +E +K KK + + ++N E Q E+N ++K +E
Sbjct: 1660 QKRKKLAKKWEKVAREEEKLAKKGGKLAE--VKNILAQKVEELPQREQNLDWQEKELAQE 1717
Query: 139 FED----------KKVELKENLIAELEEKKKMIE--------NEKLTMELTGDSMEVKPI 180
E+ K+ EL + +EEKKK+ E EKL+ E T + E + +
Sbjct: 1718 LEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELL 1777
Query: 181 MTRKLR------RRPNDPVPIPDKRRKPAPAQLNYLLTDEQ---IMEDLRTLNKLKSPKR 231
+ K + + P + + KR + ++ E+ ME+L T NK+ ++
Sbjct: 1778 IQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL-TKNKMILYQK 1836
Query: 232 PASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKRWYH-KSQAIYLESK 280
++L A E AQR ++ LY +R H K Q + +++K
Sbjct: 1837 KNLAQEKKNL-AQEKEKLAQR-----KENLLYNKERLTHSKKQLVQVKNK 1880
Score = 33.1 bits (74), Expect = 0.35
Identities = 45/187 (24%), Positives = 72/187 (38%), Gaps = 40/187 (21%)
Query: 21 EYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYV-------------- 66
+Y EE+ LE +E S G E ++ T+ +H +E++
Sbjct: 1537 QYKDEEEVTLE----EEVSREGEEKEQQV-----TEEQRHIQEEHKWARIHRKRARAEKK 1587
Query: 67 ----EMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETE 122
E K ++KLA +RQL Q + Q Y K+ Q +E + F Q E
Sbjct: 1588 RAQEERKLAQEEEKLAQEERQLAQEERKLAQAY----VKITQDDREMAQAEGKFAQKEET 1643
Query: 123 QVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMT 182
+R ++A + KK+ K +A EEK + G EVK I+
Sbjct: 1644 LAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEK---------LAKKGGKLAEVKNILA 1694
Query: 183 RKLRRRP 189
+K+ P
Sbjct: 1695 QKVEELP 1701
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 47.0 bits (110), Expect = 2e-05
Identities = 68/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)
Query: 1 MSAAGLLAP-APAQAGAPPAPEYYPEEDEELESAEDDERSC-RGRESDEDTEDASETDLA 58
++A AP PA PPAP PE +E + R RG + +
Sbjct: 151 LNAQAACAPRCPAPPRGPPAPA--PEVEELARRLGEAWRGAVRGYQ-----------ERV 197
Query: 59 KHDEEDYVEMKEQMYQDKLASL--KRQLQQLQE---GTLQEYQKRMKKLDQQYKERIRNA 113
H E + +E++ + + + +LQQLQ G L+ ++L+ +++ER+R
Sbjct: 198 AHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRAT 257
Query: 114 ELF-LQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTG 172
E F L +E + E+ ++ + A V E + LK +L E+ + ++E E ++ G
Sbjct: 258 EKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPG 317
Query: 173 DSMEVK-----PIMTRKLRRRPND-------PVPIPDKRRKPAPAQLN-----YLLTDEQ 215
+ P + + R P PV P P PA L +L E
Sbjct: 318 GGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQEF 377
Query: 216 IMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQ 251
+ TL P P +PS PA AE AQ
Sbjct: 378 LQARTPTLASTPIPPTPQAPS-----PAVDAEIRAQ 408
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 47.0 bits (110), Expect = 2e-05
Identities = 32/135 (23%), Positives = 70/135 (51%), Gaps = 6/135 (4%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
+E EE E + E+ RGR S E E + + + + ++ KE+ +++ +++
Sbjct: 107 KEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKR 166
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
++ Q G +E +K ++ +++ +ER R + E E+ ER +E+K K+ E++K
Sbjct: 167 ERKQVGEKEEERKEKERKERKKRERNRKER---KKERERKER---RERKKERKKKEERKK 220
Query: 145 ELKENLIAELEEKKK 159
E +++ EK++
Sbjct: 221 ERQKDRQTNWREKER 235
Score = 42.7 bits (99), Expect = 4e-04
Identities = 31/141 (21%), Positives = 69/141 (48%), Gaps = 12/141 (8%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
E++ + E + +++ R +E E + E + + +E++ + KE+ + + + ++
Sbjct: 74 EKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKER 133
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
++ +E +E ++R +K +++ KER E+ ER + K+ KE E K+
Sbjct: 134 ERKEERKREERKERERKKEEREKER------------ERKERKKRERKQVGEKEEERKEK 181
Query: 145 ELKENLIAELEEKKKMIENEK 165
E KE E K++ E E+
Sbjct: 182 ERKERKKRERNRKERKKERER 202
Score = 38.5 bits (88), Expect = 0.008
Identities = 43/186 (23%), Positives = 89/186 (47%), Gaps = 14/186 (7%)
Query: 25 EEDEELESAEDDER---SCRGRESDEDTEDASETDLAKHDEEDYVEMK-EQMYQDKLASL 80
E + E+E+ ++ ++ S R +E E + E + + E E K E+ +++
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKK 99
Query: 81 KRQLQQLQEGTLQEYQKRMKKLDQ-----QYKERIRNAELFLQLETEQVERNYIKEKKAA 135
+R+ ++ +EG +E +K+ +K ++ + KER R E + E+ ER KE++
Sbjct: 100 RRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEE---RKREERKERERKKEEREK 156
Query: 136 VKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPI 195
+E +++K ++ + + EE+K+ E+ E + E K RK RR
Sbjct: 157 ERERKERKKRERKQVGEKEEERKEKERKERKKRE--RNRKERKKERERKERRERKKERKK 214
Query: 196 PDKRRK 201
++R+K
Sbjct: 215 KEERKK 220
Score = 31.2 bits (69), Expect = 1.3
Identities = 35/126 (27%), Positives = 59/126 (46%), Gaps = 11/126 (8%)
Query: 43 RESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKL 102
RE + + E E K + E E K++ + + +R+ ++ +E +E + KK
Sbjct: 39 REREREIETRKE---GKKERES--ERKKERREREKRKREREKERKRERGKKEKKGERKKE 93
Query: 103 DQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEF-EDKKVELKENLIAE--LEEKKK 159
+++ K+R R E E E+ E+ KEKK + E K+ E KE E E ++K
Sbjct: 94 ERERKKRRREKE---NKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERK 150
Query: 160 MIENEK 165
E EK
Sbjct: 151 KEEREK 156
>gi|109134347 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 47.0 bits (110), Expect = 2e-05
Identities = 37/124 (29%), Positives = 67/124 (54%), Gaps = 6/124 (4%)
Query: 63 EDYVEMKEQMYQ-DKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLET 121
+D EMK Q+ KL L+ Q+QQ E ++E R + LD++ E+ R L+ E
Sbjct: 100 KDLEEMKLQILTPQKLELLRAQIQQELETPMRE---RFRNLDEEV-EKYRAVYNKLRYEH 155
Query: 122 EQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIM 181
++ + +K+ + ++ K++ E+ IA LEE K+ + N+ L ++LT DS V+ +
Sbjct: 156 TFLKSEFEHQKEEYARILDEGKIKY-ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLA 214
Query: 182 TRKL 185
K+
Sbjct: 215 REKV 218
Score = 35.0 bits (79), Expect = 0.091
Identities = 35/121 (28%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 53 SETDLAKHDEEDYVEMKEQMYQD--KLASLKRQLQQLQEGTLQEYQKRMKKLDQQYK--E 108
SE DL ++ EM E++ Q+ S + Q E TL+E K+++ L++++K E
Sbjct: 488 SENDLLNSNQM-LKEMVERLKQECRNFRSQAEKAQLEAEKTLEE--KQIQWLEEKHKLHE 544
Query: 109 RIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTM 168
RI + E E+++R I +KK + L EN + L+EK +++E +K +
Sbjct: 545 RITDREEKYNQAKEKLQRAAIAQKK---------RKSLHENKLKRLQEKVEVLEAKKEEL 595
Query: 169 E 169
E
Sbjct: 596 E 596
>gi|109134355 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 47.0 bits (110), Expect = 2e-05
Identities = 37/124 (29%), Positives = 67/124 (54%), Gaps = 6/124 (4%)
Query: 63 EDYVEMKEQMYQ-DKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLET 121
+D EMK Q+ KL L+ Q+QQ E ++E R + LD++ E+ R L+ E
Sbjct: 100 KDLEEMKLQILTPQKLELLRAQIQQELETPMRE---RFRNLDEEV-EKYRAVYNKLRYEH 155
Query: 122 EQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIM 181
++ + +K+ + ++ K++ E+ IA LEE K+ + N+ L ++LT DS V+ +
Sbjct: 156 TFLKSEFEHQKEEYARILDEGKIKY-ESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLA 214
Query: 182 TRKL 185
K+
Sbjct: 215 REKV 218
Score = 35.0 bits (79), Expect = 0.091
Identities = 35/121 (28%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 53 SETDLAKHDEEDYVEMKEQMYQD--KLASLKRQLQQLQEGTLQEYQKRMKKLDQQYK--E 108
SE DL ++ EM E++ Q+ S + Q E TL+E K+++ L++++K E
Sbjct: 488 SENDLLNSNQM-LKEMVERLKQECRNFRSQAEKAQLEAEKTLEE--KQIQWLEEKHKLHE 544
Query: 109 RIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTM 168
RI + E E+++R I +KK + L EN + L+EK +++E +K +
Sbjct: 545 RITDREEKYNQAKEKLQRAAIAQKK---------RKSLHENKLKRLQEKVEVLEAKKEEL 595
Query: 169 E 169
E
Sbjct: 596 E 596
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 46.6 bits (109), Expect = 3e-05
Identities = 33/141 (23%), Positives = 77/141 (54%), Gaps = 14/141 (9%)
Query: 27 DEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQ 86
D+E + E +E+ R E + E+ ++E+ + +E+M Q++ + Q ++
Sbjct: 506 DQEEKIREQEEKMWRQEEKIREQEEKIR------EQEEKIREQEEMMQEQEEKMGEQEEK 559
Query: 87 LQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQV--ERNYIKEKKAAVKEFEDKKV 144
+QE QE +R ++ ++ +E+IR + ++ + E++ + I+E++ ++E E+K
Sbjct: 560 MQE---QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMW 616
Query: 145 ELKENLIAELEEKKKMIENEK 165
E +E + E+++KM E E+
Sbjct: 617 EQEEKM---CEQEEKMQEQEE 634
Score = 40.0 bits (92), Expect = 0.003
Identities = 36/157 (22%), Positives = 81/157 (51%), Gaps = 26/157 (16%)
Query: 28 EELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQL 87
E+ + + +E+ R E D E+ ++E+ + +E+ +++ ++ Q +++
Sbjct: 486 EQEKIRKQEEKVWRQEEKMHDQEEKIR------EQEEKMWRQEEKIREQEEKIREQEEKI 539
Query: 88 --QEGTLQEYQKRMKKLDQ--QYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDK- 142
QE +QE +++M + ++ Q +E++R E ++ + E+ I+E+K ++E E+K
Sbjct: 540 REQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEK-----IREQKEKIREQEEKI 594
Query: 143 -----KVELKENLIAELEEK-----KKMIENEKLTME 169
K+ +E ++ E EEK +KM E E+ E
Sbjct: 595 WEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 631
Score = 38.5 bits (88), Expect = 0.008
Identities = 33/108 (30%), Positives = 59/108 (54%), Gaps = 12/108 (11%)
Query: 67 EMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVER 126
E+K ++ + KL ++QLQ + +E Q KL Q +E EL+ +L +Q E+
Sbjct: 246 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN----ELWNRLNQQQEEK 301
Query: 127 NYIKEKKAAVKEFEDKKVELKENLIAELEEK-----KKMIENEKLTME 169
+ +E+K ++E+E+ K++ +E I E EEK +KM E++ E
Sbjct: 302 MWRQEEK--IQEWEE-KIQEQEEKIREQEEKIREQEEKMRRQEEMMWE 346
Score = 37.4 bits (85), Expect = 0.018
Identities = 36/178 (20%), Positives = 83/178 (46%), Gaps = 23/178 (12%)
Query: 34 EDDERSCRGRESDEDTEDA--SETDLAKHDEEDYVEMKEQMY-QDKLASLKRQLQQLQEG 90
+ +E+ R E ++ E+ + + + EE E +E+M Q+++ K + + QE
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 356
Query: 91 TLQEYQKRMKKLDQ----------QYKERIRNAELFLQLETEQVERNYIKEKKAAVKE-- 138
+ E +++M++L++ + +E++ E + E ++ E I+E++ ++
Sbjct: 357 MMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 416
Query: 139 ---FEDKKVELKENLIAELEEK-----KKMIENEKLTMELTGDSMEVKPIMTRKLRRR 188
+++K+ +E I E E+K +K+ E EK+ E E K+R +
Sbjct: 417 KMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ 474
Score = 37.4 bits (85), Expect = 0.018
Identities = 29/135 (21%), Positives = 68/135 (50%), Gaps = 3/135 (2%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
E+ E E + E + E + E E + +E+ + +E+ +++ + RQ
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQE 443
Query: 85 QQLQEGT-LQEYQKRMKKLDQ-QYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDK 142
+++ E ++E +KR ++ + + +E+IR E + + + E+ I++++ V +++
Sbjct: 444 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWR-QEE 502
Query: 143 KVELKENLIAELEEK 157
K+ +E I E EEK
Sbjct: 503 KMHDQEEKIREQEEK 517
Score = 36.2 bits (82), Expect = 0.041
Identities = 42/215 (19%), Positives = 99/215 (46%), Gaps = 22/215 (10%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDAS--ETDLAKHDEEDYVEMKEQMY--------Q 74
E+ E E +E R +E ++ E + + + EE E +++M+ Q
Sbjct: 390 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 449
Query: 75 DKLASLKRQLQQ----LQEGTLQEYQ---KRMKKLDQQYKERIRNAELFLQLETEQVERN 127
+K+ +++ +Q QE ++E + ++ +K+ +Q K R + +++ Q E +
Sbjct: 450 EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEE 509
Query: 128 YIKEKKAAVKEFEDKKVELKENLIAELEEK----KKMIENEKLTMELTGDSMEVKPIMTR 183
I+E++ + +++K+ +E I E EEK ++M++ ++ M + M+ + M R
Sbjct: 510 KIREQEEKMWR-QEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRR 568
Query: 184 KLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIME 218
+ + I +++ K + +E+I E
Sbjct: 569 QEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE 603
Score = 34.3 bits (77), Expect = 0.16
Identities = 35/149 (23%), Positives = 77/149 (51%), Gaps = 11/149 (7%)
Query: 25 EEDEELESAEDD--ERSCRGRESDE---DTEDASETDLAKHDEEDYVEMKEQMYQDKLAS 79
E++E++ E+ E+ + RE +E + E E + + +EE E +++ Q+ A
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE--AK 417
Query: 80 LKRQLQQL--QEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVK 137
+ RQ +++ QE ++E +K+M + +++ E+ + E + E E++ R +EK +
Sbjct: 418 MWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ--EEKIREQE 475
Query: 138 EFEDKKVELKENLIAELEEKKKMIENEKL 166
E +K ++ E +E+K + EK+
Sbjct: 476 EIWRQKEKMHEQEKIRKQEEKVWRQEEKM 504
Score = 30.4 bits (67), Expect = 2.3
Identities = 39/186 (20%), Positives = 81/186 (43%), Gaps = 32/186 (17%)
Query: 21 EYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASL 80
+++P+ + + +A D + ++ + T + T H ED + Q + L
Sbjct: 69 DHHPQTNPSVGTAASDTKK---KKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRREL 125
Query: 81 KRQLQQLQEGTLQEYQKRM---------KKLDQQYKE---RIRNAELFLQLETEQVERNY 128
+ Q+ ++ T Q+ + +M K+L+ + ++ R+ ++ F E EQ
Sbjct: 126 EAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAG-ELEQALSAV 184
Query: 129 IKEKKAA-------VKEFEDKKVELKENLI---------AELEEKKKMIENEKLTMELTG 172
+KK A KE + +EL N I A+L+EK +++E+EK ++L
Sbjct: 185 ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV 244
Query: 173 DSMEVK 178
++ K
Sbjct: 245 KELKRK 250
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 46.6 bits (109), Expect = 3e-05
Identities = 63/236 (26%), Positives = 109/236 (46%), Gaps = 35/236 (14%)
Query: 28 EELESAEDDERSCRGRESDEDTEDASETDLAKHDEE-DYVEMKEQMYQDKLASLKRQLQQ 86
E+ E AE+ S GR + +D + E +A+ +EE + + + D++ +Q +Q
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 87 L------QEGTLQEYQKRMKKLDQQYKE-RIRNAEL------------------FLQLET 121
L + T Q+ + ++L++Q KE R + E+ QLE
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE- 1827
Query: 122 EQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIM 181
EQVE+ +EK+AA K + K +LKE ++ ++E+++KM E K E + VK +
Sbjct: 1828 EQVEQE-AREKQAATKSLKQKDKKLKE-ILLQVEDERKMAEQYKEQAE--KGNARVKQ-L 1882
Query: 182 TRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSS 237
R+L + I RRK +L+ + M R +N LKS R + +S
Sbjct: 1883 KRQLEEAEEESQRINANRRK-LQRELDEATESNEAMG--REVNALKSKLRRGNETS 1935
Score = 39.3 bits (90), Expect = 0.005
Identities = 40/202 (19%), Positives = 82/202 (40%), Gaps = 26/202 (12%)
Query: 21 EYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQ--------- 71
E EE +E+ D R + E A+E A+ +E +++ Q
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Query: 72 --------MYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQ 123
++ +A+L+ ++ QL+E QE +++ ++ + E+ LQ+E
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED-- 1860
Query: 124 VERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTR 183
ER ++ K ++ + +LK L EE +++ N + ++ E M R
Sbjct: 1861 -ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1919
Query: 184 KLR------RRPNDPVPIPDKR 199
++ RR N+ +P +R
Sbjct: 1920 EVNALKSKLRRGNETSFVPSRR 1941
Score = 37.4 bits (85), Expect = 0.018
Identities = 32/130 (24%), Positives = 67/130 (51%), Gaps = 19/130 (14%)
Query: 35 DDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQE 94
++ER+ + DE+ E ++ +L +H +++ + + KL ++ L+EG +
Sbjct: 1342 EEERNSLQDQLDEEME--AKQNLERHISTLNIQLSDS--KKKLQDFASTVEALEEGK-KR 1396
Query: 95 YQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVEL--KENLIA 152
+QK ++ L QQY+E+ A + +LE K K +E +D V+L + L++
Sbjct: 1397 FQKEIENLTQQYEEK---AAAYDKLE---------KTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 153 ELEEKKKMIE 162
LE+K++ +
Sbjct: 1445 NLEKKQRKFD 1454
Score = 35.8 bits (81), Expect = 0.054
Identities = 47/215 (21%), Positives = 93/215 (43%), Gaps = 40/215 (18%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
E ++EL++ ED + R + + + E DL DE++ ++K L+RQL
Sbjct: 1550 ELEDELQATEDAK--LRLEVNMQALKGQFERDLQARDEQN---------EEKRRQLQRQL 1598
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
+ + T E +++ + L K+++ L+L+ + IK ++ A+K+ +
Sbjct: 1599 HEYE--TELEDERKQRALAAAAKKKLEGDLKDLELQADSA----IKGREEAIKQLRKLQA 1652
Query: 145 ELKENLIAELEEKKKMI--------ENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIP 196
++K+ ELE+ + ENEK L D M+++ + +
Sbjct: 1653 QMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ------------EDLAAA 1699
Query: 197 DKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKR 231
++ RK A + L E++ L N L+ KR
Sbjct: 1700 ERARKQADLEKEELA--EELASSLSGRNALQDEKR 1732
Score = 28.9 bits (63), Expect = 6.6
Identities = 23/96 (23%), Positives = 47/96 (48%), Gaps = 3/96 (3%)
Query: 76 KLASLKRQLQQLQEGTL--QEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKK 133
K+ + Q + G L + + KR ++L K RN +L+L Q R + K K
Sbjct: 785 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAM-KVIQRNCAAYLKLRNWQWWRLFTKVKP 843
Query: 134 AAVKEFEDKKVELKENLIAELEEKKKMIENEKLTME 169
++++++ KE+ + + +E+++ ENE +E
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELE 879
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 46.6 bits (109), Expect = 3e-05
Identities = 63/236 (26%), Positives = 109/236 (46%), Gaps = 35/236 (14%)
Query: 28 EELESAEDDERSCRGRESDEDTEDASETDLAKHDEE-DYVEMKEQMYQDKLASLKRQLQQ 86
E+ E AE+ S GR + +D + E +A+ +EE + + + D++ +Q +Q
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 87 L------QEGTLQEYQKRMKKLDQQYKE-RIRNAEL------------------FLQLET 121
L + T Q+ + ++L++Q KE R + E+ QLE
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE- 1834
Query: 122 EQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIM 181
EQVE+ +EK+AA K + K +LKE ++ ++E+++KM E K E + VK +
Sbjct: 1835 EQVEQE-AREKQAATKSLKQKDKKLKE-ILLQVEDERKMAEQYKEQAE--KGNARVKQ-L 1889
Query: 182 TRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSS 237
R+L + I RRK +L+ + M R +N LKS R + +S
Sbjct: 1890 KRQLEEAEEESQRINANRRK-LQRELDEATESNEAMG--REVNALKSKLRRGNETS 1942
Score = 39.3 bits (90), Expect = 0.005
Identities = 40/202 (19%), Positives = 82/202 (40%), Gaps = 26/202 (12%)
Query: 21 EYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQ--------- 71
E EE +E+ D R + E A+E A+ +E +++ Q
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Query: 72 --------MYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQ 123
++ +A+L+ ++ QL+E QE +++ ++ + E+ LQ+E
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED-- 1867
Query: 124 VERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTR 183
ER ++ K ++ + +LK L EE +++ N + ++ E M R
Sbjct: 1868 -ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1926
Query: 184 KLR------RRPNDPVPIPDKR 199
++ RR N+ +P +R
Sbjct: 1927 EVNALKSKLRRGNETSFVPSRR 1948
Score = 37.4 bits (85), Expect = 0.018
Identities = 32/130 (24%), Positives = 67/130 (51%), Gaps = 19/130 (14%)
Query: 35 DDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQE 94
++ER+ + DE+ E ++ +L +H +++ + + KL ++ L+EG +
Sbjct: 1349 EEERNSLQDQLDEEME--AKQNLERHISTLNIQLSDS--KKKLQDFASTVEALEEGK-KR 1403
Query: 95 YQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVEL--KENLIA 152
+QK ++ L QQY+E+ A + +LE K K +E +D V+L + L++
Sbjct: 1404 FQKEIENLTQQYEEK---AAAYDKLE---------KTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 153 ELEEKKKMIE 162
LE+K++ +
Sbjct: 1452 NLEKKQRKFD 1461
Score = 35.8 bits (81), Expect = 0.054
Identities = 47/215 (21%), Positives = 93/215 (43%), Gaps = 40/215 (18%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
E ++EL++ ED + R + + + E DL DE++ ++K L+RQL
Sbjct: 1557 ELEDELQATEDAK--LRLEVNMQALKGQFERDLQARDEQN---------EEKRRQLQRQL 1605
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
+ + T E +++ + L K+++ L+L+ + IK ++ A+K+ +
Sbjct: 1606 HEYE--TELEDERKQRALAAAAKKKLEGDLKDLELQADSA----IKGREEAIKQLRKLQA 1659
Query: 145 ELKENLIAELEEKKKMI--------ENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIP 196
++K+ ELE+ + ENEK L D M+++ + +
Sbjct: 1660 QMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ------------EDLAAA 1706
Query: 197 DKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKR 231
++ RK A + L E++ L N L+ KR
Sbjct: 1707 ERARKQADLEKEELA--EELASSLSGRNALQDEKR 1739
Score = 28.9 bits (63), Expect = 6.6
Identities = 23/96 (23%), Positives = 47/96 (48%), Gaps = 3/96 (3%)
Query: 76 KLASLKRQLQQLQEGTL--QEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKK 133
K+ + Q + G L + + KR ++L K RN +L+L Q R + K K
Sbjct: 792 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAM-KVIQRNCAAYLKLRNWQWWRLFTKVKP 850
Query: 134 AAVKEFEDKKVELKENLIAELEEKKKMIENEKLTME 169
++++++ KE+ + + +E+++ ENE +E
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELE 886
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 46.6 bits (109), Expect = 3e-05
Identities = 63/234 (26%), Positives = 107/234 (45%), Gaps = 35/234 (14%)
Query: 28 EELESAEDDERSCRGRESDEDTEDASETDLAKHDEE-DYVEMKEQMYQDKLASLKRQLQQ 86
E+ E AE+ S GR + +D + E +A+ +EE + + + D++ +Q +Q
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 87 L------QEGTLQEYQKRMKKLDQQYKE-RIRNAEL------------------FLQLET 121
L + T Q+ + ++L++Q KE R + E+ QLE
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE- 1834
Query: 122 EQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIM 181
EQVE+ +EK+AA K + K +LKE ++ ++E+++KM E K E + VK +
Sbjct: 1835 EQVEQE-AREKQAATKSLKQKDKKLKE-ILLQVEDERKMAEQYKEQAE--KGNARVKQ-L 1889
Query: 182 TRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASP 235
R+L + I RRK +L+ + M R +N LKS R P
Sbjct: 1890 KRQLEEAEEESQRINANRRK-LQRELDEATESNEAMG--REVNALKSKLRGPPP 1940
Score = 37.4 bits (85), Expect = 0.018
Identities = 32/130 (24%), Positives = 67/130 (51%), Gaps = 19/130 (14%)
Query: 35 DDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQE 94
++ER+ + DE+ E ++ +L +H +++ + + KL ++ L+EG +
Sbjct: 1349 EEERNSLQDQLDEEME--AKQNLERHISTLNIQLSDS--KKKLQDFASTVEALEEGK-KR 1403
Query: 95 YQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVEL--KENLIA 152
+QK ++ L QQY+E+ A + +LE K K +E +D V+L + L++
Sbjct: 1404 FQKEIENLTQQYEEK---AAAYDKLE---------KTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 153 ELEEKKKMIE 162
LE+K++ +
Sbjct: 1452 NLEKKQRKFD 1461
Score = 36.6 bits (83), Expect = 0.031
Identities = 39/203 (19%), Positives = 80/203 (39%), Gaps = 27/203 (13%)
Query: 21 EYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQ--------- 71
E EE +E+ D R + E A+E A+ +E +++ Q
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Query: 72 --------MYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQ 123
++ +A+L+ ++ QL+E QE +++ ++ + E+ LQ+E
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED-- 1867
Query: 124 VERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTR 183
ER ++ K ++ + +LK L EE +++ N + ++ E M R
Sbjct: 1868 -ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1926
Query: 184 KLRRRPNDPVPIPDKRRKPAPAQ 206
++ + K R P P +
Sbjct: 1927 EVN-------ALKSKLRGPPPQE 1942
Score = 35.8 bits (81), Expect = 0.054
Identities = 47/215 (21%), Positives = 93/215 (43%), Gaps = 40/215 (18%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
E ++EL++ ED + R + + + E DL DE++ ++K L+RQL
Sbjct: 1557 ELEDELQATEDAK--LRLEVNMQALKGQFERDLQARDEQN---------EEKRRQLQRQL 1605
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
+ + T E +++ + L K+++ L+L+ + IK ++ A+K+ +
Sbjct: 1606 HEYE--TELEDERKQRALAAAAKKKLEGDLKDLELQADSA----IKGREEAIKQLRKLQA 1659
Query: 145 ELKENLIAELEEKKKMI--------ENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIP 196
++K+ ELE+ + ENEK L D M+++ + +
Sbjct: 1660 QMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ------------EDLAAA 1706
Query: 197 DKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKR 231
++ RK A + L E++ L N L+ KR
Sbjct: 1707 ERARKQADLEKEELA--EELASSLSGRNALQDEKR 1739
Score = 28.9 bits (63), Expect = 6.6
Identities = 23/96 (23%), Positives = 47/96 (48%), Gaps = 3/96 (3%)
Query: 76 KLASLKRQLQQLQEGTL--QEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKK 133
K+ + Q + G L + + KR ++L K RN +L+L Q R + K K
Sbjct: 792 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAM-KVIQRNCAAYLKLRNWQWWRLFTKVKP 850
Query: 134 AAVKEFEDKKVELKENLIAELEEKKKMIENEKLTME 169
++++++ KE+ + + +E+++ ENE +E
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELE 886
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 46.6 bits (109), Expect = 3e-05
Identities = 63/234 (26%), Positives = 107/234 (45%), Gaps = 35/234 (14%)
Query: 28 EELESAEDDERSCRGRESDEDTEDASETDLAKHDEE-DYVEMKEQMYQDKLASLKRQLQQ 86
E+ E AE+ S GR + +D + E +A+ +EE + + + D++ +Q +Q
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 87 L------QEGTLQEYQKRMKKLDQQYKE-RIRNAEL------------------FLQLET 121
L + T Q+ + ++L++Q KE R + E+ QLE
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE- 1827
Query: 122 EQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIM 181
EQVE+ +EK+AA K + K +LKE ++ ++E+++KM E K E + VK +
Sbjct: 1828 EQVEQE-AREKQAATKSLKQKDKKLKE-ILLQVEDERKMAEQYKEQAE--KGNARVKQ-L 1882
Query: 182 TRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASP 235
R+L + I RRK +L+ + M R +N LKS R P
Sbjct: 1883 KRQLEEAEEESQRINANRRK-LQRELDEATESNEAMG--REVNALKSKLRGPPP 1933
Score = 37.4 bits (85), Expect = 0.018
Identities = 32/130 (24%), Positives = 67/130 (51%), Gaps = 19/130 (14%)
Query: 35 DDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQE 94
++ER+ + DE+ E ++ +L +H +++ + + KL ++ L+EG +
Sbjct: 1342 EEERNSLQDQLDEEME--AKQNLERHISTLNIQLSDS--KKKLQDFASTVEALEEGK-KR 1396
Query: 95 YQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVEL--KENLIA 152
+QK ++ L QQY+E+ A + +LE K K +E +D V+L + L++
Sbjct: 1397 FQKEIENLTQQYEEK---AAAYDKLE---------KTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 153 ELEEKKKMIE 162
LE+K++ +
Sbjct: 1445 NLEKKQRKFD 1454
Score = 36.6 bits (83), Expect = 0.031
Identities = 39/203 (19%), Positives = 80/203 (39%), Gaps = 27/203 (13%)
Query: 21 EYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQ--------- 71
E EE +E+ D R + E A+E A+ +E +++ Q
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Query: 72 --------MYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQ 123
++ +A+L+ ++ QL+E QE +++ ++ + E+ LQ+E
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED-- 1860
Query: 124 VERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTR 183
ER ++ K ++ + +LK L EE +++ N + ++ E M R
Sbjct: 1861 -ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1919
Query: 184 KLRRRPNDPVPIPDKRRKPAPAQ 206
++ + K R P P +
Sbjct: 1920 EVN-------ALKSKLRGPPPQE 1935
Score = 35.8 bits (81), Expect = 0.054
Identities = 47/215 (21%), Positives = 93/215 (43%), Gaps = 40/215 (18%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
E ++EL++ ED + R + + + E DL DE++ ++K L+RQL
Sbjct: 1550 ELEDELQATEDAK--LRLEVNMQALKGQFERDLQARDEQN---------EEKRRQLQRQL 1598
Query: 85 QQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKV 144
+ + T E +++ + L K+++ L+L+ + IK ++ A+K+ +
Sbjct: 1599 HEYE--TELEDERKQRALAAAAKKKLEGDLKDLELQADSA----IKGREEAIKQLRKLQA 1652
Query: 145 ELKENLIAELEEKKKMI--------ENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIP 196
++K+ ELE+ + ENEK L D M+++ + +
Sbjct: 1653 QMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ------------EDLAAA 1699
Query: 197 DKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKR 231
++ RK A + L E++ L N L+ KR
Sbjct: 1700 ERARKQADLEKEELA--EELASSLSGRNALQDEKR 1732
Score = 28.9 bits (63), Expect = 6.6
Identities = 23/96 (23%), Positives = 47/96 (48%), Gaps = 3/96 (3%)
Query: 76 KLASLKRQLQQLQEGTL--QEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKK 133
K+ + Q + G L + + KR ++L K RN +L+L Q R + K K
Sbjct: 785 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAM-KVIQRNCAAYLKLRNWQWWRLFTKVKP 843
Query: 134 AAVKEFEDKKVELKENLIAELEEKKKMIENEKLTME 169
++++++ KE+ + + +E+++ ENE +E
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELE 879
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 46.6 bits (109), Expect = 3e-05
Identities = 42/159 (26%), Positives = 76/159 (47%), Gaps = 11/159 (6%)
Query: 26 EDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQ 85
E+ E AE D++ R E E A+ + + + E+ M+E+ +K A+ +RQ
Sbjct: 275 EERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREE---EKRAAEERQ-- 329
Query: 86 QLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVE 145
++E +KR + Q+ KE + A Q E+ +R + ++A +E E KVE
Sbjct: 330 -----RIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVE 384
Query: 146 LKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRK 184
++ +LEEKK ++ K+ E +E K + +K
Sbjct: 385 -EQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKK 422
Score = 45.1 bits (105), Expect = 9e-05
Identities = 45/193 (23%), Positives = 87/193 (45%), Gaps = 17/193 (8%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
EE + ++ E R R +E+ A E A+ +EE+ +++EQ +L K +
Sbjct: 340 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399
Query: 85 QQLQ---EGTLQEYQKRMKKLDQQYKERIRNAELFLQLETE----QVERNYIKEKKAAVK 137
Q+ + E Q+ + + + +++++ A L Q E + Q +R ++E K K
Sbjct: 400 QETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFK 459
Query: 138 EFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRR------RPND 191
+ E K ++K++ + EE K ++ +K E+ + E MT KL+ RP
Sbjct: 460 KEEIKDEKIKKDKEPK-EEVKSFMDRKKGFTEVKSQNGE---FMTHKLKHTENTFSRPGG 515
Query: 192 PVPIPDKRRKPAP 204
+ K + AP
Sbjct: 516 RASVDTKEAEGAP 528
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/153 (27%), Positives = 80/153 (52%), Gaps = 16/153 (10%)
Query: 25 EEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQL 84
+E+E + + DE S + +ED E A E + A+ + E+ +K + K+A + ++
Sbjct: 240 QEEEREQGS--DEISHHEKMEEEDKERA-EAERARLEAEERERIKAEQ-DKKIADERARI 295
Query: 85 QQLQEGTLQEYQKR-MKKLDQQYKERIRNAELFLQLETEQ----VERNYIK--EKKAA-- 135
+ ++ QE ++R ++ ++ +E R AE +++ E+ ER IK EK+AA
Sbjct: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
Query: 136 ---VKEFEDKKVELKENLIAELEEKKKMIENEK 165
+KE E + E ++ AE EEK K+ E ++
Sbjct: 356 RQRIKEEEKRAAEERQRARAEEEEKAKVEEQKR 388
Score = 37.4 bits (85), Expect = 0.018
Identities = 36/146 (24%), Positives = 74/146 (50%), Gaps = 21/146 (14%)
Query: 24 PEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQ 83
P+++EE E D E S + +ED E A E + A+ + E+ +K + K+A + +
Sbjct: 238 PKQEEEREQGSD-EISHHEKMEEEDKERA-EAERARLEAEERERIKAEQ-DKKIADERAR 294
Query: 84 LQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKK 143
++ ++ QE ++R + + +ER+R E E ++++ +EK+AA +++
Sbjct: 295 IEAEEKAAAQERERR----EAEERERMREEEKRAAEERQRIKE---EEKRAA-----EER 342
Query: 144 VELKENLIAELEEKKKMIENEKLTME 169
+KE EEK+ E +++ E
Sbjct: 343 QRIKE------EEKRAAEERQRIKEE 362
>gi|112734867 retinitis pigmentosa GTPase regulator interacting
protein 1 [Homo sapiens]
Length = 1286
Score = 46.2 bits (108), Expect = 4e-05
Identities = 43/168 (25%), Positives = 82/168 (48%), Gaps = 24/168 (14%)
Query: 52 ASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQ--EGTLQEYQKRMKKLDQQYKER 109
A+ L K E E+KE+ K SLK QL+ + + TL+E+Q+R++ L+++ K
Sbjct: 317 AAHEALLKQVNELRAELKEE--SKKAVSLKSQLEDVSILQMTLKEFQERVEDLEKERKLL 374
Query: 110 IRNAELFLQ--LETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMI------ 161
N + L+ L++ + ++ + + +L++ L AELE+K+K++
Sbjct: 375 NDNYDKLLESMLDSSDSSSQPHWSNELIAEQLQQQVSQLQDQLDAELEDKRKVLLELSRE 434
Query: 162 --ENEKLTMELTG----DSMEVKPIMTRKLRRRPNDPVPIPDKRRKPA 203
+NE L +E+T EV+ + +P PD++ +PA
Sbjct: 435 KAQNEDLKLEVTNILQKHKQEVELLQNAATISQP------PDRQSEPA 476
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.349
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,243,654
Number of Sequences: 37866
Number of extensions: 708328
Number of successful extensions: 10280
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 308
Number of HSP's successfully gapped in prelim test: 905
Number of HSP's that attempted gapping in prelim test: 6252
Number of HSP's gapped (non-prelim): 3705
length of query: 328
length of database: 18,247,518
effective HSP length: 103
effective length of query: 225
effective length of database: 14,347,320
effective search space: 3228147000
effective search space used: 3228147000
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.