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Search of human proteins with 71274148
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71274148 pleckstrin homology domain containing, family G
(with RhoGef domain) member 1 [Homo sapiens]
(1385 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71274148 pleckstrin homology domain containing, family G (wit... 2768 0.0
gi|55749621 pleckstrin homology domain containing, family G, mem... 381 e-105
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 333 9e-91
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 141 4e-33
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 141 4e-33
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 139 2e-32
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 139 2e-32
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 134 6e-31
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 131 4e-30
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 128 3e-29
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 128 3e-29
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 128 4e-29
gi|193211603 pleckstrin homology domain containing, family G (wi... 125 4e-28
gi|193211598 pleckstrin homology domain containing, family G (wi... 125 4e-28
gi|193211596 pleckstrin homology domain containing, family G (wi... 125 4e-28
gi|193211594 pleckstrin homology domain containing, family G (wi... 125 4e-28
gi|55742734 pleckstrin homology domain containing, family G (wit... 125 4e-28
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 122 2e-27
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 120 1e-26
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 120 1e-26
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 117 6e-26
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 117 1e-25
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 117 1e-25
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 117 1e-25
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 117 1e-25
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 117 1e-25
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 117 1e-25
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 117 1e-25
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 115 2e-25
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 114 5e-25
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 2768 bits (7176), Expect = 0.0
Identities = 1385/1385 (100%), Positives = 1385/1385 (100%)
Query: 1 MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPAR 60
MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPAR
Sbjct: 1 MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPAR 60
Query: 61 PFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQE 120
PFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQE
Sbjct: 61 PFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQE 120
Query: 121 ILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENC 180
ILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENC
Sbjct: 121 ILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENC 180
Query: 181 ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLP 240
ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLP
Sbjct: 181 ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLP 240
Query: 241 LGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHA 300
LGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHA
Sbjct: 241 LGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHA 300
Query: 301 VRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTY 360
VRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTY
Sbjct: 301 VRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTY 360
Query: 361 KAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHA 420
KAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHA
Sbjct: 361 KAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHA 420
Query: 421 AKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLK 480
AKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLK
Sbjct: 421 AKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLK 480
Query: 481 TSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQ 540
TSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQ
Sbjct: 481 TSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQ 540
Query: 541 ALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSS 600
ALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSS
Sbjct: 541 ALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSS 600
Query: 601 SGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHV 660
SGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHV
Sbjct: 601 SGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHV 660
Query: 661 YDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGT 720
YDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGT
Sbjct: 661 YDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGT 720
Query: 721 LSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDS 780
LSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDS
Sbjct: 721 LSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDS 780
Query: 781 LRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWN 840
LRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWN
Sbjct: 781 LRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWN 840
Query: 841 DLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALL 900
DLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALL
Sbjct: 841 DLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALL 900
Query: 901 TPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPE 960
TPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPE
Sbjct: 901 TPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPE 960
Query: 961 NPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAI 1020
NPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAI
Sbjct: 961 NPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAI 1020
Query: 1021 LEEKKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGS 1080
LEEKKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGS
Sbjct: 1021 LEEKKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGS 1080
Query: 1081 GDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPG 1140
GDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPG
Sbjct: 1081 GDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPG 1140
Query: 1141 SVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPS 1200
SVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPS
Sbjct: 1141 SVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPS 1200
Query: 1201 DVGKQQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQ 1260
DVGKQQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQ
Sbjct: 1201 DVGKQQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQ 1260
Query: 1261 IATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNT 1320
IATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNT
Sbjct: 1261 IATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNT 1320
Query: 1321 LHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLS 1380
LHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLS
Sbjct: 1321 LHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLS 1380
Query: 1381 SSSFA 1385
SSSFA
Sbjct: 1381 SSSFA 1385
>gi|55749621 pleckstrin homology domain containing, family G, member
3 [Homo sapiens]
Length = 1163
Score = 381 bits (978), Expect = e-105
Identities = 291/801 (36%), Positives = 379/801 (47%), Gaps = 192/801 (23%)
Query: 7 DRPVSFGST-SSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARPFSSS 65
+RPVS ST SSS SS DS S M S+S PA+ + S
Sbjct: 14 ERPVSLTSTTSSSGSSCDSR----SAMEEPSSSEA-----------------PAKNGAGS 52
Query: 66 ELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETE 125
R P + ++ + + P + + + P KL Y+ RVV+EI+ETE
Sbjct: 53 LRSRHLPNSNNNSSSWLNVKGPLSPFNSRAAAGP-------AHHKLSYLGRVVREIVETE 105
Query: 126 RTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPV 185
R YV QDL +
Sbjct: 106 RMYV---------------------------------------------QDLRS------ 114
Query: 186 AIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYL 245
+ +S+EF IYTQYC NYP SVA LTECMR+K AKFFR+RQE L+HSLPLGSYL
Sbjct: 115 ------IVESQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYL 168
Query: 246 LKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQE 305
LKPVQRILKYHLLL EI H D++ +G++VV DAIDTM VAW+INDMKR+HEHAVRLQE
Sbjct: 169 LKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQE 228
Query: 306 IQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTYKAHIL 365
IQSLL NWKGPDLT+YGELVLEGTFR+ R +NERT FLFDK LLITKKR D F YK +I
Sbjct: 229 IQSLLINWKGPDLTTYGELVLEGTFRVHRVRNERTFFLFDKTLLITKKRGDHFVYKGNIP 288
Query: 366 CGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPA 425
C +LML+E ++ L F+V HYK+ K Q+++QAK+ ++KR W H+KRLILENH A IP
Sbjct: 289 CSSLMLIE-STRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQ 347
Query: 426 KAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRL-RRKSEPSSRSHKVLKTSET 484
KAK+AILEMD+ + + SPE KA E S R RR+SEP+ + L
Sbjct: 348 KAKEAILEMDSYYPNRYRCSPERLKKAWSSQDEVSTNVRQGRRQSEPTKHLLRQLNEKAR 407
Query: 485 AQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQI--RQAL 542
A ++ R E SS RPS P+S+ + +L + D + Q +
Sbjct: 408 AAGMKGKGRRESESSRSSRRPS----GRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEV 463
Query: 543 FPSRRSPQENEDDED------------------------DYQMFVPSFSSSDL------- 571
F + P E D D FV + S+ DL
Sbjct: 464 FSAVEGPSAEETPSDTESPEVLETQLDAHQGLLGMDPPGDMVDFVAAESTEDLKALSSEE 523
Query: 572 ---------------------NSTRLCEDSTSSRPCSWHMGQMESTETSSSGHRIVRRAS 610
++ + E SS + Q +S + R+V R+S
Sbjct: 524 EEEMGGAAQEPESLLPPSVLDQASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSS 583
Query: 611 ----------------SAGESNTC--PPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIE- 651
SA +S +C PE+ S ++SP G E +P G +E
Sbjct: 584 SVLSLEGSEKGLARHGSATDSLSCQLSPEVDISVGV-ATEDSPSVNGMEPPSP-GCPVEP 641
Query: 652 -----------------LTIDDIDHVYDNISYEDLKLMVAKREEAESTPSKSARDSVR-- 692
L +D I Y+N + D V +RE P R+S+
Sbjct: 642 DRSSCKKKESALSTRDRLLLDKIKSYYENAEHHDAGFSVRRRESLSYIPKGLVRNSISRF 701
Query: 693 ---PKSTPE---LAFTKRQAG 707
P+ PE +KRQ G
Sbjct: 702 NSLPRPDPEPVPPVGSKRQVG 722
Score = 42.0 bits (97), Expect = 0.004
Identities = 48/187 (25%), Positives = 79/187 (42%), Gaps = 17/187 (9%)
Query: 969 TDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKS-----MHKDLAAILEE 1023
+++ K++V+ +ARQYS +IK ++ L+ E+ + KS + ++ L
Sbjct: 863 SERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEKVAPERDGKSPTVPCLQEEAGEPLGG 922
Query: 1024 KKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGSGDW 1083
K + P + + +Y QL Q SP K G SPQ S + G
Sbjct: 923 KGKRKPVLS--LFDYEQLMAQ---EHSPPKPSSAGEMSPQRFFFNPSAVSQRTTSPGGRP 977
Query: 1084 LLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKS---TPR--QLSAACSVPSLQTSDPL 1138
S S E F P ++L S+Y + + ++ PR ++ + SVP PL
Sbjct: 978 SARSPLSPTE--TFSWPDVRELCSKYASRDEARRAGGGRPRGPPVNRSHSVPENMVEPPL 1035
Query: 1139 PGSVQRC 1145
G V RC
Sbjct: 1036 SGRVGRC 1042
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 333 bits (853), Expect = 9e-91
Identities = 188/371 (50%), Positives = 242/371 (65%), Gaps = 13/371 (3%)
Query: 71 NPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQ 130
+PA G A S P + + +P I SA +L +RV +EI+ETER YV+
Sbjct: 63 DPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRL---ERVAREIVETERAYVR 119
Query: 131 DLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAEC 190
DL+SIVEDYL + D L L E+ LF NI+DIY F+SELL+DLEN + IAEC
Sbjct: 120 DLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLEN-SSSAGGIAEC 178
Query: 191 FVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQ 250
FV +SE+F IYT YC NYP S+A+L E + A + +ERQ L+HSLPL S+LLKPVQ
Sbjct: 179 FVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQ 238
Query: 251 RILKYHLLLHEIENHLDK--DTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQS 308
RILKYHLLL E+ H + T G ++V +AI +M VAW+INDMKRK EHA RLQE+Q
Sbjct: 239 RILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQR 298
Query: 309 LLTNWKGPDLTSYGELVLEGTFR------IQRAKNERTLFLFDKLLLITKKRDDTFTYKA 362
L W GP+L+++GELVLEG FR + ER LFLF ++LL+ K+R +TYK
Sbjct: 299 RLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKG 358
Query: 363 HILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAK 422
HI C NL + E P++PL F V PK +H +QAK+Q++KRLW+ L+RL ENH A
Sbjct: 359 HIFCCNLSVSE-SPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPAS 417
Query: 423 IPAKAKQAILE 433
IPAKAKQ +LE
Sbjct: 418 IPAKAKQVLLE 428
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 141 bits (356), Expect = 4e-33
Identities = 113/418 (27%), Positives = 203/418 (48%), Gaps = 60/418 (14%)
Query: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGT----EERSALFGNIQDIYHFNSE 172
V+ E+L+TER YV++L ++E Y + + L + ++ LFGN+++IYHF++
Sbjct: 662 VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNR 721
Query: 173 L-LQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRER 231
+ L++LEN + P + CF+ + E+F IY +YC N PRS ++ +C FF+E
Sbjct: 722 IFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSD----CPFFQEC 777
Query: 232 QETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHIN 291
Q L H L L SYLLKPVQRI KY LLL E+ + ++ EG + + +A+ ++ + +N
Sbjct: 778 QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKY-SRNCEGAEDLQEALSSILGILKAVN 836
Query: 292 DMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI--------QRAKN------ 337
D H + +T + G +L G+L+++G+F + + K
Sbjct: 837 DSM----HLI-------AITGYDG-NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKP 884
Query: 338 -ERTLFLFDKLLLITKKRDD---------TFTYKAHILCGNLMLVEVIPKEPLSFSVFHY 387
+R LFL +K +L KKR++ +++YK + + + E + + F +++
Sbjct: 885 MQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN 944
Query: 388 KNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPG-FCYSP 446
++ + VQA + + K WV +++++ A A +A+ + ++ P SP
Sbjct: 945 AREEV-YIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSP 1003
Query: 447 EGGTKALFGSKEGSAPYRLRRKSEPSS-----RSHKVLKTSETAQDIQKVSREEGSPQ 499
G E RK++P S S + K E + K S +P+
Sbjct: 1004 SRGNSRNIKKLE-------ERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPE 1054
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 141 bits (356), Expect = 4e-33
Identities = 113/418 (27%), Positives = 203/418 (48%), Gaps = 60/418 (14%)
Query: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGT----EERSALFGNIQDIYHFNSE 172
V+ E+L+TER YV++L ++E Y + + L + ++ LFGN+++IYHF++
Sbjct: 609 VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNR 668
Query: 173 L-LQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRER 231
+ L++LEN + P + CF+ + E+F IY +YC N PRS ++ +C FF+E
Sbjct: 669 IFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSD----CPFFQEC 724
Query: 232 QETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHIN 291
Q L H L L SYLLKPVQRI KY LLL E+ + ++ EG + + +A+ ++ + +N
Sbjct: 725 QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKY-SRNCEGAEDLQEALSSILGILKAVN 783
Query: 292 DMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI--------QRAKN------ 337
D H + +T + G +L G+L+++G+F + + K
Sbjct: 784 DSM----HLI-------AITGYDG-NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKP 831
Query: 338 -ERTLFLFDKLLLITKKRDD---------TFTYKAHILCGNLMLVEVIPKEPLSFSVFHY 387
+R LFL +K +L KKR++ +++YK + + + E + + F +++
Sbjct: 832 MQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN 891
Query: 388 KNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPG-FCYSP 446
++ + VQA + + K WV +++++ A A +A+ + ++ P SP
Sbjct: 892 AREEV-YIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSP 950
Query: 447 EGGTKALFGSKEGSAPYRLRRKSEPSS-----RSHKVLKTSETAQDIQKVSREEGSPQ 499
G E RK++P S S + K E + K S +P+
Sbjct: 951 SRGNSRNIKKLE-------ERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPE 1001
>gi|153791628 MCF.2 cell line derived transforming sequence isoform
a [Homo sapiens]
Length = 985
Score = 139 bits (349), Expect = 2e-32
Identities = 108/398 (27%), Positives = 191/398 (47%), Gaps = 52/398 (13%)
Query: 61 PFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQE 120
PF SS+ + Q N E P Q + S P + D+ S +L + V+ E
Sbjct: 508 PFFSSKQGKKTWRQNQSNLK--IEVVPDCQEKRSSG--PSSSLDNGNSLDVLK-NHVLNE 562
Query: 121 ILETERTYVQDLKSIVEDYLDCIRDQTKL----PLGTEERSALFGNIQDIYHFNSEL-LQ 175
+++TER YV++L +++ Y + + PL ++ LFGN+ +IY F++++ L
Sbjct: 563 LIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLS 622
Query: 176 DLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETL 235
LENC + P + CF+ + ++F +Y +YC N PRS + R FF+E Q L
Sbjct: 623 SLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETI----WRKYSECAFFQECQRKL 678
Query: 236 KHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKR 295
KH L L SYLLKPVQRI KY LLL E+ + KD EG ++ A+D M + +ND
Sbjct: 679 KHRLRLDSYLLKPVQRITKYQLLLKELLKY-SKDCEGSALLKKALDAMLDLLKSVND--- 734
Query: 296 KHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI--------QRAKN-------ERT 340
+ + N +L G+++++G F + + K+ +R
Sbjct: 735 ---------SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRH 785
Query: 341 LFLFDKLLLITKKRDD---------TFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPK 391
LFL++K ++ K+R + ++++K + + E + + F +++ + +
Sbjct: 786 LFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEE 845
Query: 392 LQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQ 429
+ + VQA + K W+ ++ ++L+ K KQ
Sbjct: 846 V-YIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQ 882
>gi|153791325 MCF.2 cell line derived transforming sequence isoform
b [Homo sapiens]
Length = 925
Score = 139 bits (349), Expect = 2e-32
Identities = 108/398 (27%), Positives = 191/398 (47%), Gaps = 52/398 (13%)
Query: 61 PFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQE 120
PF SS+ + Q N E P Q + S P + D+ S +L + V+ E
Sbjct: 448 PFFSSKQGKKTWRQNQSNLK--IEVVPDCQEKRSSG--PSSSLDNGNSLDVLK-NHVLNE 502
Query: 121 ILETERTYVQDLKSIVEDYLDCIRDQTKL----PLGTEERSALFGNIQDIYHFNSEL-LQ 175
+++TER YV++L +++ Y + + PL ++ LFGN+ +IY F++++ L
Sbjct: 503 LIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLS 562
Query: 176 DLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETL 235
LENC + P + CF+ + ++F +Y +YC N PRS + R FF+E Q L
Sbjct: 563 SLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETI----WRKYSECAFFQECQRKL 618
Query: 236 KHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKR 295
KH L L SYLLKPVQRI KY LLL E+ + KD EG ++ A+D M + +ND
Sbjct: 619 KHRLRLDSYLLKPVQRITKYQLLLKELLKY-SKDCEGSALLKKALDAMLDLLKSVND--- 674
Query: 296 KHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI--------QRAKN-------ERT 340
+ + N +L G+++++G F + + K+ +R
Sbjct: 675 ---------SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRH 725
Query: 341 LFLFDKLLLITKKRDD---------TFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPK 391
LFL++K ++ K+R + ++++K + + E + + F +++ + +
Sbjct: 726 LFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEE 785
Query: 392 LQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQ 429
+ + VQA + K W+ ++ ++L+ K KQ
Sbjct: 786 V-YIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQ 822
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 134 bits (337), Expect = 6e-31
Identities = 93/317 (29%), Positives = 166/317 (52%), Gaps = 36/317 (11%)
Query: 117 VVQEILETERTYVQDLKSIVEDYL-DCIRDQTKLPLGTEERSAL-FGNIQDIYHFNSEL- 173
++ E+++TE+ YV+DL+ ++ YL + ++P G + + FGN+Q+IY F++ +
Sbjct: 1296 IMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIF 1355
Query: 174 LQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQE 233
L++LE E P + CFV+ +++F +Y YC N P S ++ E +F E Q+
Sbjct: 1356 LKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILE-----HAGSYFDEIQQ 1410
Query: 234 TLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDM 293
+ + SYL+KPVQRI KY LLL E+ L EG + D ++ M V ND
Sbjct: 1411 RHGLANSISSYLIKPVQRITKYQLLLKEL---LTCCEEGKGEIKDGLEVMLSVPKRAND- 1466
Query: 294 KRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQ------RAKNERTLFLFDKL 347
A+ L ++ N + S GEL+L+ +F++ R ER LFLF+
Sbjct: 1467 ------AMHLSMLEGFDEN-----IESQGELILQESFQVWDPKTLIRKGRERHLFLFEMS 1515
Query: 348 LLITKKRDDT-----FTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTV--QAKS 400
L+ +K+ D+ + YK+ + L + E + +P F+++ + P + + +A S
Sbjct: 1516 LVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASS 1575
Query: 401 QQDKRLWVLHLKRLILE 417
++K+ W+ H++ +I E
Sbjct: 1576 IENKQDWIKHIREVIQE 1592
Score = 127 bits (318), Expect = 1e-28
Identities = 117/440 (26%), Positives = 187/440 (42%), Gaps = 35/440 (7%)
Query: 95 SNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTE 154
S+ +P + S L V+QE++ETER YV+DL +VE Y+ +++
Sbjct: 1951 SSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKG 2010
Query: 155 ERSALFGNIQDIYHFNSEL-LQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVA 213
+ +FGNI IY ++ + L +LE C DP + FV H+Y YC N P+S
Sbjct: 2011 KDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEH 2070
Query: 214 VLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGY 273
+++E + FF + ++ L H L L L+KPVQRI+KY LLL + + K +
Sbjct: 2071 IVSE-----YIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDT 2125
Query: 274 DVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQ 333
+ A++ M V NDM + RLQ + + G+L+L+ TF +
Sbjct: 2126 SELERAVEVMCIVPRRCNDMM----NVGRLQGFDG--------KIVAQGKLLLQDTFLVT 2173
Query: 334 RAK-------NERTLFLFDKLLLITKKRDDT-------FTYKAHILCGNLMLVEVIPKEP 379
ER +FLF+++++ ++ D F +K I L L E + +P
Sbjct: 2174 DQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVENDP 2233
Query: 380 LSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHH 439
F++ ++ + S R +H ILEN + A + +E H
Sbjct: 2234 CKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFL--NALTSPIEYQRNHS 2291
Query: 440 PGFCYSPEGGTKALFGSKEGSAPY-RLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSP 498
G GG+ GS G AP PSS + I + R
Sbjct: 2292 GGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSRIPQPVRHHPPV 2351
Query: 499 QLSSARPSPAQRNSQPSSST 518
+SSA S A+ + +ST
Sbjct: 2352 LVSSAASSQAEADKMSGTST 2371
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 131 bits (330), Expect = 4e-30
Identities = 96/314 (30%), Positives = 153/314 (48%), Gaps = 25/314 (7%)
Query: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQD 176
V+ EI+ TER Y++ LK I E YL R + + E+ +FGNI+DIY F ++D
Sbjct: 107 VINEIMSTERHYIKHLKDICEGYLKQCRKRRDM-FSDEQLKVIFGNIEDIYRFQMGFVRD 165
Query: 177 LENCEN--DP--VAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFF---R 229
LE N DP I CF+ + F IY++YC N+ + L++ M++ FF R
Sbjct: 166 LEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACR 225
Query: 230 ERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWH 289
Q+ + + + +LL PVQ+I KY L L E+ + +D Y V A+ M+ V
Sbjct: 226 LLQQMI--DIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQ 283
Query: 290 INDMKRKHEHAVRLQEIQSLLTNWKGPD-LTSYGELVLEG----TFRIQRAKNERTLFLF 344
IN+ KR+ E+ ++ + Q+ + +W+G D L EL+ G ++ +R FLF
Sbjct: 284 INERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLF 343
Query: 345 DKLLLITKK---RDDTFTYKAHILCGNLMLVEVIPKEPLSFSV-------FHYKNPKLQH 394
D +++ KK R D YK I +V++ F+V H K + H
Sbjct: 344 DHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIH 403
Query: 395 TVQAKSQQDKRLWV 408
AK ++K W+
Sbjct: 404 LFFAKKLEEKIRWL 417
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 128 bits (322), Expect = 3e-29
Identities = 95/317 (29%), Positives = 163/317 (51%), Gaps = 36/317 (11%)
Query: 117 VVQEILETERTYVQDLKSIVEDYL-DCIRDQTKLPLGT-EERSALFGNIQDIYHFNSEL- 173
++ E+L+TE+ YV+DL +E YL + ++P G + +FGNIQ+IY F++ +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344
Query: 174 LQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQE 233
L++LE E P + CFV+ +++F +Y YC N P S ++ E FF E Q+
Sbjct: 1345 LKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILE-----HAGTFFDEIQQ 1399
Query: 234 TLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDM 293
+ + SYL+KPVQRI KY LLL E+ L EG + D ++ M V ND
Sbjct: 1400 RHGLANSISSYLIKPVQRITKYQLLLKEL---LTCCEEGKGELKDGLEVMLSVPKKAND- 1455
Query: 294 KRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKN------ERTLFLFDKL 347
A+ + ++ N L GEL+L+ F++ K+ ER LFLF+
Sbjct: 1456 ------AMHVSMLEGFDEN-----LDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEIS 1504
Query: 348 LLITKKRDDT-----FTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH--TVQAKS 400
L+ +K+ D+ + YK +L L + E + +P F+++ + P + ++A +
Sbjct: 1505 LVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASN 1564
Query: 401 QQDKRLWVLHLKRLILE 417
+ K+ W+ +++ +I E
Sbjct: 1565 IETKQEWIKNIREVIQE 1581
Score = 115 bits (289), Expect = 2e-25
Identities = 123/518 (23%), Positives = 228/518 (44%), Gaps = 64/518 (12%)
Query: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSEL-LQ 175
V+ E+++TE+ YV+DL +VE ++ I ++ + +FGNI IY ++ + L
Sbjct: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLA 1992
Query: 176 DLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETL 235
+LE C + +A+ F+ + HIY YC N PRS ++ E +F E ++ +
Sbjct: 1993 ELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAE------YDAYFEEVKQEI 2046
Query: 236 KHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKR 295
L L +L+KP+QRI KY LLL + + +K + A++ M V NDM
Sbjct: 2047 NQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMM- 2105
Query: 296 KHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI-------QRAKNERTLFLFDKLL 348
+ RLQ + LT+ G+L+ + TF + Q ER +FLF++++
Sbjct: 2106 ---NLGRLQGFEG--------TLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIV 2154
Query: 349 LITK-----KRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQD 403
+ ++ + +K I L+L E + +P F++ + + + + +QA +
Sbjct: 2155 IFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSE-RVVLQAANADI 2213
Query: 404 KRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPY 463
++ WV + + +LE + A Q+ +E Y + + A+ S+ P
Sbjct: 2214 QQAWVQDINQ-VLETQRDFL--NALQSPIE----------YQRKERSTAVMRSQPARLPQ 2260
Query: 464 RLRRK-SEPSSRSHKVLKTSETAQDIQ--KVSREEGSPQLSSARPSPAQRNSQP------ 514
R S + S K K S + K+S GSP +P S+
Sbjct: 2261 ASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGC 2320
Query: 515 SSSTMISVLRAGGALRN---IWTDHQIRQALFPSRRSP----QENEDDEDDYQMFVPSFS 567
+ ++ ++V++ AL+ + ++ Q L ++++ Q D + +VP
Sbjct: 2321 NGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSI 2380
Query: 568 SSDLNSTRLCEDSTSS--RPCSWHMGQM-ESTETSSSG 602
+ L E S S + CSWH +M + E ++G
Sbjct: 2381 LAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTG 2418
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 128 bits (322), Expect = 3e-29
Identities = 95/317 (29%), Positives = 163/317 (51%), Gaps = 36/317 (11%)
Query: 117 VVQEILETERTYVQDLKSIVEDYL-DCIRDQTKLPLGT-EERSALFGNIQDIYHFNSEL- 173
++ E+L+TE+ YV+DL +E YL + ++P G + +FGNIQ+IY F++ +
Sbjct: 1285 IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIF 1344
Query: 174 LQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQE 233
L++LE E P + CFV+ +++F +Y YC N P S ++ E FF E Q+
Sbjct: 1345 LKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILE-----HAGTFFDEIQQ 1399
Query: 234 TLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDM 293
+ + SYL+KPVQRI KY LLL E+ L EG + D ++ M V ND
Sbjct: 1400 RHGLANSISSYLIKPVQRITKYQLLLKEL---LTCCEEGKGELKDGLEVMLSVPKKAND- 1455
Query: 294 KRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKN------ERTLFLFDKL 347
A+ + ++ N L GEL+L+ F++ K+ ER LFLF+
Sbjct: 1456 ------AMHVSMLEGFDEN-----LDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEIS 1504
Query: 348 LLITKKRDDT-----FTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH--TVQAKS 400
L+ +K+ D+ + YK +L L + E + +P F+++ + P + ++A +
Sbjct: 1505 LVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASN 1564
Query: 401 QQDKRLWVLHLKRLILE 417
+ K+ W+ +++ +I E
Sbjct: 1565 IETKQEWIKNIREVIQE 1581
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 128 bits (321), Expect = 4e-29
Identities = 89/272 (32%), Positives = 135/272 (49%), Gaps = 17/272 (6%)
Query: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQD 176
V++EI++TER Y++ L+ I E Y+ R T + + + +FGNI+DIY F + L+D
Sbjct: 244 VIREIMDTERVYIKHLRDICEGYIRQCRKHTGM-FTVAQLATIFGNIEDIYKFQRKFLKD 302
Query: 177 LENCENDPVA----IAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFF---R 229
LE N I CF+ E F IY++YC N+P + L M+ FF R
Sbjct: 303 LEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACR 362
Query: 230 ERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWH 289
Q+ + + + +LL PVQ+I KY L L E+ + ++ Y + A + M+ VA
Sbjct: 363 LLQQMI--DIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACL 420
Query: 290 INDMKRKHEHAVRLQEIQSLLTNWKGPD-LTSYGELVLEG---TFRIQRAKNERTLFLFD 345
IN+ KRK E ++ Q + W+G D L EL+ G Q +RT FLFD
Sbjct: 421 INERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFD 480
Query: 346 KLLLITKK---RDDTFTYKAHILCGNLMLVEV 374
L+ KK R D YK + + LV++
Sbjct: 481 HQLVSCKKDLLRRDMLYYKGRLDMDEMELVDL 512
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 125 bits (313), Expect = 4e-28
Identities = 102/342 (29%), Positives = 161/342 (47%), Gaps = 29/342 (8%)
Query: 85 RPPRAQWRVDSNGAPKTIADSATSPKLLY-VDRVVQEILETERTYVQDLKSIVEDYLDCI 143
R P A +P ++ P+ L + V+ E++ TER YV+ L+ +E+Y +
Sbjct: 622 RRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPEL 681
Query: 144 RDQTKLPLGTE-ERSALFGNIQDIYHFNSEL-LQDLENCENDPVAIAECFVSKSEEFHIY 201
D+ +P G +R+ LFGN++ + F+ L++LE C P +A F+ +F +Y
Sbjct: 682 -DRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMY 740
Query: 202 TQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHE 261
Y N PRS A+++ FF+++Q+ L L L SYLLKP+QR+ KY LLL E
Sbjct: 741 ALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQE 795
Query: 262 IENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSY 321
+ T+ + +A + H ND+ + + IQ N L
Sbjct: 796 LARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN-----LKEQ 843
Query: 322 GELVLEGTF--RIQRAKNERTLFLFDKLLLITKKRD-----DTFTYKAHILCGNLMLVEV 374
G+LV + F R R K+ R +FLF++LLL +K R DTF YK +L L E
Sbjct: 844 GQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTEC 903
Query: 375 IPKEPLSFSV-FHYKNPKLQHTVQAKSQQDKRLWVLHLKRLI 415
L F + F + + +QA S K+ W + L+
Sbjct: 904 CGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 945
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 125 bits (313), Expect = 4e-28
Identities = 102/342 (29%), Positives = 161/342 (47%), Gaps = 29/342 (8%)
Query: 85 RPPRAQWRVDSNGAPKTIADSATSPKLLY-VDRVVQEILETERTYVQDLKSIVEDYLDCI 143
R P A +P ++ P+ L + V+ E++ TER YV+ L+ +E+Y +
Sbjct: 703 RRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPEL 762
Query: 144 RDQTKLPLGTE-ERSALFGNIQDIYHFNSEL-LQDLENCENDPVAIAECFVSKSEEFHIY 201
D+ +P G +R+ LFGN++ + F+ L++LE C P +A F+ +F +Y
Sbjct: 763 -DRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMY 821
Query: 202 TQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHE 261
Y N PRS A+++ FF+++Q+ L L L SYLLKP+QR+ KY LLL E
Sbjct: 822 ALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQE 876
Query: 262 IENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSY 321
+ T+ + +A + H ND+ + + IQ N L
Sbjct: 877 LARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN-----LKEQ 924
Query: 322 GELVLEGTF--RIQRAKNERTLFLFDKLLLITKKRD-----DTFTYKAHILCGNLMLVEV 374
G+LV + F R R K+ R +FLF++LLL +K R DTF YK +L L E
Sbjct: 925 GQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTEC 984
Query: 375 IPKEPLSFSV-FHYKNPKLQHTVQAKSQQDKRLWVLHLKRLI 415
L F + F + + +QA S K+ W + L+
Sbjct: 985 CGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 1026
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 125 bits (313), Expect = 4e-28
Identities = 102/342 (29%), Positives = 161/342 (47%), Gaps = 29/342 (8%)
Query: 85 RPPRAQWRVDSNGAPKTIADSATSPKLLY-VDRVVQEILETERTYVQDLKSIVEDYLDCI 143
R P A +P ++ P+ L + V+ E++ TER YV+ L+ +E+Y +
Sbjct: 703 RRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPEL 762
Query: 144 RDQTKLPLGTE-ERSALFGNIQDIYHFNSEL-LQDLENCENDPVAIAECFVSKSEEFHIY 201
D+ +P G +R+ LFGN++ + F+ L++LE C P +A F+ +F +Y
Sbjct: 763 -DRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMY 821
Query: 202 TQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHE 261
Y N PRS A+++ FF+++Q+ L L L SYLLKP+QR+ KY LLL E
Sbjct: 822 ALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQE 876
Query: 262 IENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSY 321
+ T+ + +A + H ND+ + + IQ N L
Sbjct: 877 LARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN-----LKEQ 924
Query: 322 GELVLEGTF--RIQRAKNERTLFLFDKLLLITKKRD-----DTFTYKAHILCGNLMLVEV 374
G+LV + F R R K+ R +FLF++LLL +K R DTF YK +L L E
Sbjct: 925 GQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTEC 984
Query: 375 IPKEPLSFSV-FHYKNPKLQHTVQAKSQQDKRLWVLHLKRLI 415
L F + F + + +QA S K+ W + L+
Sbjct: 985 CGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 1026
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 125 bits (313), Expect = 4e-28
Identities = 102/342 (29%), Positives = 161/342 (47%), Gaps = 29/342 (8%)
Query: 85 RPPRAQWRVDSNGAPKTIADSATSPKLLY-VDRVVQEILETERTYVQDLKSIVEDYLDCI 143
R P A +P ++ P+ L + V+ E++ TER YV+ L+ +E+Y +
Sbjct: 703 RRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPEL 762
Query: 144 RDQTKLPLGTE-ERSALFGNIQDIYHFNSEL-LQDLENCENDPVAIAECFVSKSEEFHIY 201
D+ +P G +R+ LFGN++ + F+ L++LE C P +A F+ +F +Y
Sbjct: 763 -DRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMY 821
Query: 202 TQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHE 261
Y N PRS A+++ FF+++Q+ L L L SYLLKP+QR+ KY LLL E
Sbjct: 822 ALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQE 876
Query: 262 IENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSY 321
+ T+ + +A + H ND+ + + IQ N L
Sbjct: 877 LARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN-----LKEQ 924
Query: 322 GELVLEGTF--RIQRAKNERTLFLFDKLLLITKKRD-----DTFTYKAHILCGNLMLVEV 374
G+LV + F R R K+ R +FLF++LLL +K R DTF YK +L L E
Sbjct: 925 GQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTEC 984
Query: 375 IPKEPLSFSV-FHYKNPKLQHTVQAKSQQDKRLWVLHLKRLI 415
L F + F + + +QA S K+ W + L+
Sbjct: 985 CGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 1026
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 125 bits (313), Expect = 4e-28
Identities = 102/342 (29%), Positives = 161/342 (47%), Gaps = 29/342 (8%)
Query: 85 RPPRAQWRVDSNGAPKTIADSATSPKLLY-VDRVVQEILETERTYVQDLKSIVEDYLDCI 143
R P A +P ++ P+ L + V+ E++ TER YV+ L+ +E+Y +
Sbjct: 703 RRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPEL 762
Query: 144 RDQTKLPLGTE-ERSALFGNIQDIYHFNSEL-LQDLENCENDPVAIAECFVSKSEEFHIY 201
D+ +P G +R+ LFGN++ + F+ L++LE C P +A F+ +F +Y
Sbjct: 763 -DRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMY 821
Query: 202 TQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHE 261
Y N PRS A+++ FF+++Q+ L L L SYLLKP+QR+ KY LLL E
Sbjct: 822 ALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQE 876
Query: 262 IENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSY 321
+ T+ + +A + H ND+ + + IQ N L
Sbjct: 877 LARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN-----LKEQ 924
Query: 322 GELVLEGTF--RIQRAKNERTLFLFDKLLLITKKRD-----DTFTYKAHILCGNLMLVEV 374
G+LV + F R R K+ R +FLF++LLL +K R DTF YK +L L E
Sbjct: 925 GQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTEC 984
Query: 375 IPKEPLSFSV-FHYKNPKLQHTVQAKSQQDKRLWVLHLKRLI 415
L F + F + + +QA S K+ W + L+
Sbjct: 985 CGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 1026
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 122 bits (306), Expect = 2e-27
Identities = 93/298 (31%), Positives = 146/298 (48%), Gaps = 21/298 (7%)
Query: 75 GQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDR-VVQEILETERTYVQDLK 133
G A + + PRA + P A + S + L + V+ EIL TER YV L+
Sbjct: 10 GGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLR 69
Query: 134 SIVEDYLDCIR----DQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCEN-DPVA-- 186
+ +L IR D + L E LF NI+DI + + L LE C + +P +
Sbjct: 70 FLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQH 129
Query: 187 -IAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRE------RQETLKHSL 239
+ F+ ++F +Y +YC+N+ +++ +L E + + F R+ T +
Sbjct: 130 ELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTT---DI 186
Query: 240 PLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEH 299
PL YLL P+QRI KY LLL E+ + V A+ M+ V +IN+ KR+ E
Sbjct: 187 PLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEK 246
Query: 300 AVRLQEIQSLLTNWKGPDLTSY-GELVLEGTFRIQRAKN--ERTLFLFDKLLLITKKR 354
L+++QS + W+G +LT +L+L+GT A N ER FLFD LL+ K++
Sbjct: 247 LEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRK 304
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 120 bits (300), Expect = 1e-26
Identities = 84/271 (30%), Positives = 133/271 (49%), Gaps = 14/271 (5%)
Query: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQD 176
V+ EIL TER Y++ L+ I E Y+ R + + E+ +FGNI+DIY ++
Sbjct: 288 VINEILSTERDYIKHLRDICEGYVRQCRKRADM-FSEEQLRTIFGNIEDIYRCQKAFVKA 346
Query: 177 LE---NCENDPVA-IAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQ 232
LE N E ++ + CF+ +F IY++YC N+P + L+ + FF +
Sbjct: 347 LEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACR 406
Query: 233 ETLKH-SLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHIN 291
K + L +LL PVQ+I KY L L E+ + + V A+ M+ VA IN
Sbjct: 407 LLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLIN 466
Query: 292 DMKRKHEHAVRLQEIQSLLTNWKGPD-LTSYGELVLEGTF----RIQRAKNERTLFLFDK 346
+ KR+ E+ ++ + QS + +W+G D L EL+ G + Q +R FLFD
Sbjct: 467 ERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDH 526
Query: 347 LLLITKK---RDDTFTYKAHILCGNLMLVEV 374
L+ KK R D YK + L +V++
Sbjct: 527 QLIYCKKDLLRRDVLYYKGRLDMDGLEVVDL 557
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 120 bits (300), Expect = 1e-26
Identities = 84/271 (30%), Positives = 133/271 (49%), Gaps = 14/271 (5%)
Query: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQD 176
V+ EIL TER Y++ L+ I E Y+ R + + E+ +FGNI+DIY ++
Sbjct: 288 VINEILSTERDYIKHLRDICEGYVRQCRKRADM-FSEEQLRTIFGNIEDIYRCQKAFVKA 346
Query: 177 LE---NCENDPVA-IAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQ 232
LE N E ++ + CF+ +F IY++YC N+P + L+ + FF +
Sbjct: 347 LEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACR 406
Query: 233 ETLKH-SLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHIN 291
K + L +LL PVQ+I KY L L E+ + + V A+ M+ VA IN
Sbjct: 407 LLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLIN 466
Query: 292 DMKRKHEHAVRLQEIQSLLTNWKGPD-LTSYGELVLEGTF----RIQRAKNERTLFLFDK 346
+ KR+ E+ ++ + QS + +W+G D L EL+ G + Q +R FLFD
Sbjct: 467 ERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDH 526
Query: 347 LLLITKK---RDDTFTYKAHILCGNLMLVEV 374
L+ KK R D YK + L +V++
Sbjct: 527 QLIYCKKDLLRRDVLYYKGRLDMDGLEVVDL 557
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 117 bits (294), Expect = 6e-26
Identities = 89/313 (28%), Positives = 157/313 (50%), Gaps = 43/313 (13%)
Query: 70 DNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYV 129
D+ A G + E + PPR R S+ AD + +V+QE+++TE++YV
Sbjct: 1070 DSQANGMEGPRENQDPPPRPLARHLSD------ADR--------LRKVIQELVDTEKSYV 1115
Query: 130 QDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLE---------NC 180
+DL + E YL+ ++++T L +E +LFG++ ++ F L+ LE N
Sbjct: 1116 KDLSCLFELYLEPLQNETFLT--QDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNT 1173
Query: 181 ENDP-------VAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQE 233
P ++ F+ ++ F +Y+ +C N+ + VL +K F R
Sbjct: 1174 LETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNP 1233
Query: 234 TLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDM 293
T +HS L SYL+KPVQR+LKY LLL E+ + D+++E + + +A+ M++VA HIN+M
Sbjct: 1234 TKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEM 1293
Query: 294 KRKHEH--AVRLQEIQSLLTNWKGPDLTSYGELVLEGT-------FRIQRAKN--ERTLF 342
++ +E V Q + K S GEL++ T + +A+ E T+F
Sbjct: 1294 QKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVF 1353
Query: 343 LFDKLLLITKKRD 355
+F + +++ K +
Sbjct: 1354 VFKRAVILVYKEN 1366
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 117 bits (292), Expect = 1e-25
Identities = 88/312 (28%), Positives = 152/312 (48%), Gaps = 18/312 (5%)
Query: 113 YVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172
Y + V+Q ILETE Y ++L++++ YL + QT L + S L GN+++I F
Sbjct: 93 YYNVVLQNILETENEYSKELQTVLSTYLRPL--QTSEKLSSANISYLMGNLEEICSFQQM 150
Query: 173 LLQDLENCENDPVA---IAECFVSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFF 228
L+Q LE C P A + CF++ + +Y YC N+P +V VLTE ++ L +F
Sbjct: 151 LVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFM 208
Query: 229 RERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAW 288
+ + L L + L KP R+ KY LL E+E H++ + ++ + ++
Sbjct: 209 ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSA 268
Query: 289 HINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRA----KNERTLFLF 344
+++++ E + LQ + + NW+G D+ + G + IQ A KNER L LF
Sbjct: 269 QCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLF 326
Query: 345 DKLLLI--TKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH-TVQAKSQ 401
+LL+ R F Y+ + + + ++ E + F ++ V +Q
Sbjct: 327 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSEN-HRNAFEISGSMIERILVSCNNQ 385
Query: 402 QDKRLWVLHLKR 413
QD + WV HL++
Sbjct: 386 QDLQEWVEHLQK 397
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 117 bits (292), Expect = 1e-25
Identities = 88/312 (28%), Positives = 152/312 (48%), Gaps = 18/312 (5%)
Query: 113 YVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172
Y + V+Q ILETE Y ++L++++ YL + QT L + S L GN+++I F
Sbjct: 221 YYNVVLQNILETENEYSKELQTVLSTYLRPL--QTSEKLSSANISYLMGNLEEICSFQQM 278
Query: 173 LLQDLENCENDPVA---IAECFVSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFF 228
L+Q LE C P A + CF++ + +Y YC N+P +V VLTE ++ L +F
Sbjct: 279 LVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFM 336
Query: 229 RERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAW 288
+ + L L + L KP R+ KY LL E+E H++ + ++ + ++
Sbjct: 337 ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSA 396
Query: 289 HINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRA----KNERTLFLF 344
+++++ E + LQ + + NW+G D+ + G + IQ A KNER L LF
Sbjct: 397 QCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLF 454
Query: 345 DKLLLI--TKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH-TVQAKSQ 401
+LL+ R F Y+ + + + ++ E + F ++ V +Q
Sbjct: 455 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSEN-HRNAFEISGSMIERILVSCNNQ 513
Query: 402 QDKRLWVLHLKR 413
QD + WV HL++
Sbjct: 514 QDLQEWVEHLQK 525
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 117 bits (292), Expect = 1e-25
Identities = 88/312 (28%), Positives = 152/312 (48%), Gaps = 18/312 (5%)
Query: 113 YVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172
Y + V+Q ILETE Y ++L++++ YL + QT L + S L GN+++I F
Sbjct: 271 YYNVVLQNILETENEYSKELQTVLSTYLRPL--QTSEKLSSANISYLMGNLEEICSFQQM 328
Query: 173 LLQDLENCENDPVA---IAECFVSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFF 228
L+Q LE C P A + CF++ + +Y YC N+P +V VLTE ++ L +F
Sbjct: 329 LVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFM 386
Query: 229 RERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAW 288
+ + L L + L KP R+ KY LL E+E H++ + ++ + ++
Sbjct: 387 ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSA 446
Query: 289 HINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRA----KNERTLFLF 344
+++++ E + LQ + + NW+G D+ + G + IQ A KNER L LF
Sbjct: 447 QCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLF 504
Query: 345 DKLLLI--TKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH-TVQAKSQ 401
+LL+ R F Y+ + + + ++ E + F ++ V +Q
Sbjct: 505 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSEN-HRNAFEISGSMIERILVSCNNQ 563
Query: 402 QDKRLWVLHLKR 413
QD + WV HL++
Sbjct: 564 QDLQEWVEHLQK 575
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 117 bits (292), Expect = 1e-25
Identities = 88/312 (28%), Positives = 152/312 (48%), Gaps = 18/312 (5%)
Query: 113 YVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172
Y + V+Q ILETE Y ++L++++ YL + QT L + S L GN+++I F
Sbjct: 250 YYNVVLQNILETENEYSKELQTVLSTYLRPL--QTSEKLSSANISYLMGNLEEICSFQQM 307
Query: 173 LLQDLENCENDPVA---IAECFVSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFF 228
L+Q LE C P A + CF++ + +Y YC N+P +V VLTE ++ L +F
Sbjct: 308 LVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFM 365
Query: 229 RERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAW 288
+ + L L + L KP R+ KY LL E+E H++ + ++ + ++
Sbjct: 366 ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSA 425
Query: 289 HINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRA----KNERTLFLF 344
+++++ E + LQ + + NW+G D+ + G + IQ A KNER L LF
Sbjct: 426 QCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLF 483
Query: 345 DKLLLI--TKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH-TVQAKSQ 401
+LL+ R F Y+ + + + ++ E + F ++ V +Q
Sbjct: 484 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSEN-HRNAFEISGSMIERILVSCNNQ 542
Query: 402 QDKRLWVLHLKR 413
QD + WV HL++
Sbjct: 543 QDLQEWVEHLQK 554
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 117 bits (292), Expect = 1e-25
Identities = 88/312 (28%), Positives = 152/312 (48%), Gaps = 18/312 (5%)
Query: 113 YVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172
Y + V+Q ILETE Y ++L++++ YL + QT L + S L GN+++I F
Sbjct: 93 YYNVVLQNILETENEYSKELQTVLSTYLRPL--QTSEKLSSANISYLMGNLEEICSFQQM 150
Query: 173 LLQDLENCENDPVA---IAECFVSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFF 228
L+Q LE C P A + CF++ + +Y YC N+P +V VLTE ++ L +F
Sbjct: 151 LVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTE--HSEELGEFM 208
Query: 229 RERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAW 288
+ + L L + L KP R+ KY LL E+E H++ + ++ + ++
Sbjct: 209 ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSA 268
Query: 289 HINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRA----KNERTLFLF 344
+++++ E + LQ + + NW+G D+ + G + IQ A KNER L LF
Sbjct: 269 QCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLF 326
Query: 345 DKLLLI--TKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQH-TVQAKSQ 401
+LL+ R F Y+ + + + ++ E + F ++ V +Q
Sbjct: 327 PNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSEN-HRNAFEISGSMIERILVSCNNQ 385
Query: 402 QDKRLWVLHLKR 413
QD + WV HL++
Sbjct: 386 QDLQEWVEHLQK 397
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 117 bits (292), Expect = 1e-25
Identities = 78/255 (30%), Positives = 130/255 (50%), Gaps = 20/255 (7%)
Query: 117 VVQEILETERTYVQDLKSIVEDYL----DCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172
V+ E+ +TER YV L+ +V +L C + + E LF NI+DI + E
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 173 LLQDLENC----ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFF 228
L+ +E C N + CF+ ++F IY +YC+N+ ++ +L E + + + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFL 146
Query: 229 RE------RQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDT 282
R+ T +PL YL+ P+QRI KY L+L E+ + Y V++A+
Sbjct: 147 LNCMLLGGRKNT---DVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQA 203
Query: 283 MQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLT-SYGELVLEGTFRIQRAKN--ER 339
M+ V +IN+ KR+ E L+E QS + W+G ++T + E+++ G + N ER
Sbjct: 204 MKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQER 263
Query: 340 TLFLFDKLLLITKKR 354
FLFD LL+ K++
Sbjct: 264 VFFLFDNLLVYCKRK 278
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 117 bits (292), Expect = 1e-25
Identities = 78/255 (30%), Positives = 130/255 (50%), Gaps = 20/255 (7%)
Query: 117 VVQEILETERTYVQDLKSIVEDYL----DCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172
V+ E+ +TER YV L+ +V +L C + + E LF NI+DI + E
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 173 LLQDLENC----ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFF 228
L+ +E C N + CF+ ++F IY +YC+N+ ++ +L E + + + F
Sbjct: 87 FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFL 146
Query: 229 RE------RQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDT 282
R+ T +PL YL+ P+QRI KY L+L E+ + Y V++A+
Sbjct: 147 LNCMLLGGRKNT---DVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQA 203
Query: 283 MQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLT-SYGELVLEGTFRIQRAKN--ER 339
M+ V +IN+ KR+ E L+E QS + W+G ++T + E+++ G + N ER
Sbjct: 204 MKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQER 263
Query: 340 TLFLFDKLLLITKKR 354
FLFD LL+ K++
Sbjct: 264 VFFLFDNLLVYCKRK 278
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 115 bits (289), Expect = 2e-25
Identities = 123/518 (23%), Positives = 228/518 (44%), Gaps = 64/518 (12%)
Query: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSEL-LQ 175
V+ E+++TE+ YV+DL +VE ++ I ++ + +FGNI IY ++ + L
Sbjct: 236 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLA 295
Query: 176 DLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETL 235
+LE C + +A+ F+ + HIY YC N PRS ++ E +F E ++ +
Sbjct: 296 ELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAE------YDAYFEEVKQEI 349
Query: 236 KHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKR 295
L L +L+KP+QRI KY LLL + + +K + A++ M V NDM
Sbjct: 350 NQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMM- 408
Query: 296 KHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI-------QRAKNERTLFLFDKLL 348
+ RLQ + LT+ G+L+ + TF + Q ER +FLF++++
Sbjct: 409 ---NLGRLQGFEG--------TLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIV 457
Query: 349 LITK-----KRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQD 403
+ ++ + +K I L+L E + +P F++ + + + + +QA +
Sbjct: 458 IFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSE-RVVLQAANADI 516
Query: 404 KRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPY 463
++ WV + + +LE + A Q+ +E Y + + A+ S+ P
Sbjct: 517 QQAWVQDINQ-VLETQRDFL--NALQSPIE----------YQRKERSTAVMRSQPARLPQ 563
Query: 464 RLRRK-SEPSSRSHKVLKTSETAQDIQ--KVSREEGSPQLSSARPSPAQRNSQP------ 514
R S + S K K S + K+S GSP +P S+
Sbjct: 564 ASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGC 623
Query: 515 SSSTMISVLRAGGALRN---IWTDHQIRQALFPSRRSP----QENEDDEDDYQMFVPSFS 567
+ ++ ++V++ AL+ + ++ Q L ++++ Q D + +VP
Sbjct: 624 NGTSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSI 683
Query: 568 SSDLNSTRLCEDSTSS--RPCSWHMGQM-ESTETSSSG 602
+ L E S S + CSWH +M + E ++G
Sbjct: 684 LAPLTKATAAESSDGSIKKSCSWHTLRMRKRAEVENTG 721
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 114 bits (286), Expect = 5e-25
Identities = 78/267 (29%), Positives = 141/267 (52%), Gaps = 29/267 (10%)
Query: 116 RVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQ 175
+V+QE+++TE++YV+DL + E YL+ ++++T L +E +LFG++ ++ F L+
Sbjct: 27 KVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLT--QDEMESLFGSLPEMLEFQKVFLE 84
Query: 176 DLE---------NCENDP-------VAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECM 219
LE N P ++ F+ ++ F +Y+ +C N+ + VL
Sbjct: 85 TLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAK 144
Query: 220 RNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDA 279
+K F R T +HS L SYL+KPVQR+LKY LLL E+ + D+++E + + +A
Sbjct: 145 TDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEA 204
Query: 280 IDTMQRVAWHINDMKRKHEH--AVRLQEIQSLLTNWKGPDLTSYGELVLEGT-------F 330
+ M++VA HIN+M++ +E V Q + K S GEL++ T
Sbjct: 205 LKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFL 264
Query: 331 RIQRAKN--ERTLFLFDKLLLITKKRD 355
+ +A+ E T+F+F + +++ K +
Sbjct: 265 SLGKARKDLELTVFVFKRAVILVYKEN 291
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,505,627
Number of Sequences: 37866
Number of extensions: 2562831
Number of successful extensions: 7978
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 7464
Number of HSP's gapped (non-prelim): 379
length of query: 1385
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1270
effective length of database: 13,892,928
effective search space: 17644018560
effective search space used: 17644018560
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.