Search of human proteins with 71274109

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71274109 nuclear factor of kappa light polypeptide gene
enhancer in B-cells inhibitor, epsilon [Homo sapiens]
         (500 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71274109 nuclear factor of kappa light polypeptide gene enhan...  1015   0.0  
gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]                     169   5e-42
gi|10092619 nuclear factor of kappa light polypeptide gene enhan...   141   2e-33
gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]          136   4e-32
gi|117320531 nuclear factor of kappa light polypeptide gene enha...   135   1e-31
gi|117320540 nuclear factor of kappa light polypeptide gene enha...   135   1e-31
gi|117320527 nuclear factor of kappa light polypeptide gene enha...   135   1e-31
gi|21361135 nuclear factor of kappa light polypeptide gene enhan...   133   3e-31
gi|48928017 nuclear factor of kappa light polypeptide gene enhan...   113   5e-25
gi|53832024 nuclear factor of kappa light polypeptide gene enhan...    91   2e-18
gi|13899229 nuclear factor of kappa light polypeptide gene enhan...    91   2e-18
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         88   2e-17
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...    86   8e-17
gi|41281709 nuclear factor of kappa light polypeptide gene enhan...    85   2e-16
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        84   2e-16
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         84   2e-16
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         84   2e-16
gi|89363047 death-associated protein kinase 1 [Homo sapiens]           82   9e-16
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    82   1e-15
gi|30348954 mindbomb homolog 1 [Homo sapiens]                          81   3e-15
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        80   4e-15
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         80   4e-15
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         80   4e-15
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         80   4e-15
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         80   4e-15
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...    80   6e-15
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   80   6e-15
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     77   5e-14
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]           76   8e-14
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]         76   8e-14

>gi|71274109 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, epsilon [Homo sapiens]
          Length = 500

 Score = 1015 bits (2624), Expect = 0.0
 Identities = 500/500 (100%), Positives = 500/500 (100%)

Query: 1   MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGAIRVRRPCWSGGAGRG 60
           MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGAIRVRRPCWSGGAGRG
Sbjct: 1   MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGAIRVRRPCWSGGAGRG 60

Query: 61  GGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRPPRAGRPLCQADPQPGKAAR 120
           GGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRPPRAGRPLCQADPQPGKAAR
Sbjct: 61  GGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRPPRAGRPLCQADPQPGKAAR 120

Query: 121 RSLEPDPAQTGPRPARAAGMSEARKGPDEAEESQYDSGIESLRSLRSLPESTSAPASGPS 180
           RSLEPDPAQTGPRPARAAGMSEARKGPDEAEESQYDSGIESLRSLRSLPESTSAPASGPS
Sbjct: 121 RSLEPDPAQTGPRPARAAGMSEARKGPDEAEESQYDSGIESLRSLRSLPESTSAPASGPS 180

Query: 181 DGSPQPCTHPPGPVKEPQEKEDADGERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPH 240
           DGSPQPCTHPPGPVKEPQEKEDADGERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPH
Sbjct: 181 DGSPQPCTHPPGPVKEPQEKEDADGERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPH 240

Query: 241 VGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHL 300
           VGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHL
Sbjct: 241 VGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHL 300

Query: 301 AVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHS 360
           AVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHS
Sbjct: 301 AVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHS 360

Query: 361 LDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLV 420
           LDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLV
Sbjct: 361 LDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLV 420

Query: 421 QFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEES 480
           QFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEES
Sbjct: 421 QFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEES 480

Query: 481 LVLLPFDDLKISGKLLLCTD 500
           LVLLPFDDLKISGKLLLCTD
Sbjct: 481 LVLLPFDDLKISGKLLLCTD 500


>gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]
          Length = 454

 Score =  169 bits (428), Expect = 5e-42
 Identities = 110/263 (41%), Positives = 145/263 (55%), Gaps = 17/263 (6%)

Query: 219 YTLSLLGGPEAEDPAPRLPLPHVGALSPQQ------LEALTYISEDGDTLVHLAVIH-EA 271
           Y    +G P    P   LP P    + P +      +   T   EDGDT +H+AV+    
Sbjct: 92  YPTRAMGSPF---PLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNL 148

Query: 272 PAV-LLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTA 330
           PAV  L  L       LDI NNL QT LHLAV    P  VR LV  GAS    DRHG TA
Sbjct: 149 PAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTA 208

Query: 331 LHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLL 390
            H+AC+ +   C R LL+    PG     +LDL+ +N+ GL  LH+A   + Q  ++LLL
Sbjct: 209 AHLACEHRSPTCLRALLDSAA-PG-----TLDLEARNYDGLTALHVAVNTECQETVQLLL 262

Query: 391 RNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLM 450
             GADID  +  SG++ L  AVE     +VQ LLQ GA V+A+M +G + LH A+GRGL+
Sbjct: 263 ERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLL 322

Query: 451 GISSTLCKAGADSLLRNVEDETP 473
            +  TL ++GADS L+N  ++TP
Sbjct: 323 PLVRTLVRSGADSSLKNCHNDTP 345



 Score = 32.7 bits (73), Expect = 0.79
 Identities = 25/74 (33%), Positives = 35/74 (47%), Gaps = 2/74 (2%)

Query: 267 VIHEAPAVLLCCLALLPQEVLDIQNNLYQ--TALHLAVHLDQPGAVRALVLKGASRALQD 324
           +IH      L  + LL Q   ++   +Y   +ALH A        VR LV  GA  +L++
Sbjct: 280 LIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKN 339

Query: 325 RHGDTALHVACQRQ 338
            H DT L VA  R+
Sbjct: 340 CHNDTPLMVARSRR 353



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 25/80 (31%), Positives = 32/80 (40%), Gaps = 4/80 (5%)

Query: 404 GKTALHLAVETQE----RGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKA 459
           G T LH+AV          LV    Q G ++D       TPLHLA    L  +   L  A
Sbjct: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194

Query: 460 GADSLLRNVEDETPQDLTEE 479
           GA  +  +   +T   L  E
Sbjct: 195 GASPMALDRHGQTAAHLACE 214


>gi|10092619 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, alpha [Homo sapiens]
          Length = 317

 Score =  141 bits (355), Expect = 2e-33
 Identities = 94/250 (37%), Positives = 138/250 (55%), Gaps = 12/250 (4%)

Query: 255 ISEDGDTLVHLAVIHEAPAVLLCCLALLPQEV--LDIQNNLYQTALHLAVHLDQPGAVRA 312
           ++EDGD+ +HLA+IHE  A+ +  +  +  ++  L+ QNNL QT LHLAV  +QP    A
Sbjct: 70  LTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEA 129

Query: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLA 372
           L+  G    L+D  G+T LH+AC++  LA    L +    P     HS+ L+  N+ G  
Sbjct: 130 LLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHL---HSI-LKATNYNGHT 185

Query: 373 CLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDA 432
           CLH+A++     ++ELL+  GAD++ QE  +G+TALHLAV+ Q   LV  LL+ GA V+ 
Sbjct: 186 CLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNR 245

Query: 433 RMLNGCTPLHLAAGRGLMGISSTLCKAGADSL--LRNVEDE----TPQDLTEESLVLLPF 486
               G +P  L  GR    I   L +   ++L  L   EDE    T  + TE +   LP+
Sbjct: 246 VTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPY 305

Query: 487 DDLKISGKLL 496
           DD    G+ L
Sbjct: 306 DDCVFGGQRL 315


>gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
          Length = 969

 Score =  136 bits (343), Expect = 4e-32
 Identities = 99/296 (33%), Positives = 152/296 (51%), Gaps = 32/296 (10%)

Query: 199 EKEDADGERADSTYGSSSLTYTLSLLGGPEAE--------DPAPRLPLPHVGALSPQQLE 250
           E  + D E +++T G+  +T T +     E+         + A +L   H  AL    + 
Sbjct: 464 ETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVT 523

Query: 251 A-----------LTYIS-EDGDTLVHLAVIHEAPAVLLCCL----ALLPQEVLDIQNNLY 294
                       LT +  E+GD+++HLA+IH    ++   L     L+  ++++++N+LY
Sbjct: 524 GDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLY 583

Query: 295 QTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG 354
           QT LHLAV   Q   V  L+  GA  +L DR G++ LH+A +  H      LL+ +    
Sbjct: 584 QTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKA-- 641

Query: 355 RGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVET 414
                +L L   N  GL  +H+A +  + P + LL+  GAD++ QE  SG+TALHLAVE 
Sbjct: 642 -----ALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEH 696

Query: 415 QERGLVQ-FLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVE 469
               L    LL+  A VD+   +G TPLH+AAGRG   +++ L  AGAD L+ N E
Sbjct: 697 DNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFE 752


>gi|117320531 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform a [Homo sapiens]
          Length = 900

 Score =  135 bits (339), Expect = 1e-31
 Identities = 111/338 (32%), Positives = 161/338 (47%), Gaps = 24/338 (7%)

Query: 147 PDEAEESQYDSGIESLRSLRSLPESTSAPASGPSDGSPQPCTHPPGPVKEPQEKEDADG- 205
           P     S Y SG   +             A+ PS  S +    P  P + PQ +  A   
Sbjct: 380 PSSLAYSPYQSGAGPMGCYPGGGGGAQMAATVPSRDSGEEAAEPSAPSRTPQCEPQAPEM 439

Query: 206 -----ERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPHVGALSPQQLEALTYISEDGD 260
                E     +G +  +    L  G  A+            AL   Q   LT   E+GD
Sbjct: 440 LQRAREYNARLFGLAQRSARALLDYGVTAD----------ARALLAGQRHLLTAQDENGD 489

Query: 261 TLVHLAVIHEAPAVLLCCLALLPQE----VLDIQNNLYQTALHLAVHLDQPGAVRALVLK 316
           T +HLA+IH   +V+   + ++       V+++ N+L+QT LHLAV   Q   V  L+  
Sbjct: 490 TPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRV 549

Query: 317 GASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHI 376
           GA  AL DRHGD+A+H+A +    A A  LL    + G      L L + +++GL  +H+
Sbjct: 550 GADPALLDRHGDSAMHLALRAG--AGAPELLRALLQSGAPAVPQL-LHMPDFEGLYPVHL 606

Query: 377 ATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLL-QAGAQVDARML 435
           A   ++   ++LL+ +GA+++  E   G+TALHLA E +E GLV  L+ +  A V+AR  
Sbjct: 607 AVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTF 666

Query: 436 NGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
            G TPLHLAAG G   ++  L KAGAD    N E   P
Sbjct: 667 AGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCP 704


>gi|117320540 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform b [Homo sapiens]
          Length = 899

 Score =  135 bits (339), Expect = 1e-31
 Identities = 111/338 (32%), Positives = 161/338 (47%), Gaps = 24/338 (7%)

Query: 147 PDEAEESQYDSGIESLRSLRSLPESTSAPASGPSDGSPQPCTHPPGPVKEPQEKEDADG- 205
           P     S Y SG   +             A+ PS  S +    P  P + PQ +  A   
Sbjct: 380 PSSLAYSPYQSGAGPMGCYPGGGGGAQMAATVPSRDSGEEAAEPSAPSRTPQCEPQAPEM 439

Query: 206 -----ERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPHVGALSPQQLEALTYISEDGD 260
                E     +G +  +    L  G  A+            AL   Q   LT   E+GD
Sbjct: 440 LQRAREYNARLFGLAQRSARALLDYGVTAD----------ARALLAGQRHLLTAQDENGD 489

Query: 261 TLVHLAVIHEAPAVLLCCLALLPQE----VLDIQNNLYQTALHLAVHLDQPGAVRALVLK 316
           T +HLA+IH   +V+   + ++       V+++ N+L+QT LHLAV   Q   V  L+  
Sbjct: 490 TPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRV 549

Query: 317 GASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHI 376
           GA  AL DRHGD+A+H+A +    A A  LL    + G      L L + +++GL  +H+
Sbjct: 550 GADPALLDRHGDSAMHLALRAG--AGAPELLRALLQSGAPAVPQL-LHMPDFEGLYPVHL 606

Query: 377 ATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLL-QAGAQVDARML 435
           A   ++   ++LL+ +GA+++  E   G+TALHLA E +E GLV  L+ +  A V+AR  
Sbjct: 607 AVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTF 666

Query: 436 NGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
            G TPLHLAAG G   ++  L KAGAD    N E   P
Sbjct: 667 AGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCP 704


>gi|117320527 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform b [Homo sapiens]
          Length = 899

 Score =  135 bits (339), Expect = 1e-31
 Identities = 111/338 (32%), Positives = 161/338 (47%), Gaps = 24/338 (7%)

Query: 147 PDEAEESQYDSGIESLRSLRSLPESTSAPASGPSDGSPQPCTHPPGPVKEPQEKEDADG- 205
           P     S Y SG   +             A+ PS  S +    P  P + PQ +  A   
Sbjct: 380 PSSLAYSPYQSGAGPMGCYPGGGGGAQMAATVPSRDSGEEAAEPSAPSRTPQCEPQAPEM 439

Query: 206 -----ERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPHVGALSPQQLEALTYISEDGD 260
                E     +G +  +    L  G  A+            AL   Q   LT   E+GD
Sbjct: 440 LQRAREYNARLFGLAQRSARALLDYGVTAD----------ARALLAGQRHLLTAQDENGD 489

Query: 261 TLVHLAVIHEAPAVLLCCLALLPQE----VLDIQNNLYQTALHLAVHLDQPGAVRALVLK 316
           T +HLA+IH   +V+   + ++       V+++ N+L+QT LHLAV   Q   V  L+  
Sbjct: 490 TPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRV 549

Query: 317 GASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHI 376
           GA  AL DRHGD+A+H+A +    A A  LL    + G      L L + +++GL  +H+
Sbjct: 550 GADPALLDRHGDSAMHLALRAG--AGAPELLRALLQSGAPAVPQL-LHMPDFEGLYPVHL 606

Query: 377 ATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLL-QAGAQVDARML 435
           A   ++   ++LL+ +GA+++  E   G+TALHLA E +E GLV  L+ +  A V+AR  
Sbjct: 607 AVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTF 666

Query: 436 NGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
            G TPLHLAAG G   ++  L KAGAD    N E   P
Sbjct: 667 AGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCP 704


>gi|21361135 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, beta isoform a [Homo sapiens]
          Length = 356

 Score =  133 bits (335), Expect = 3e-31
 Identities = 86/226 (38%), Positives = 117/226 (51%), Gaps = 38/226 (16%)

Query: 254 YISEDGDTLVHLAVIHEAPAVLLCCLALLP-QEVLDIQNNLYQTALHLAVHLDQPGAVRA 312
           Y++EDGDT +HLAVIH+    L   L      E +D+QN+L QTALHLA  L +   V  
Sbjct: 53  YVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEK 112

Query: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR---------------GT 357
           L   GA   + +R G TALH+AC+    ACAR LL+ RP   R                T
Sbjct: 113 LYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDT 172

Query: 358 SHS----------------------LDLQLQNWQGLACLHIATLQKNQPLMELLLRNGAD 395
           +H+                      L L+ +N++G   LH+A + K+  ++ LL   GAD
Sbjct: 173 NHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGAD 232

Query: 396 IDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPL 441
           +D  E T G++ LHLAVE Q   +++ LL+AGA   ARM  G TPL
Sbjct: 233 LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 278



 Score = 35.8 bits (81), Expect = 0.093
 Identities = 36/110 (32%), Positives = 50/110 (45%), Gaps = 11/110 (10%)

Query: 248 QLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQN---NLYQTALHLAVHL 304
           QLEA  Y   +G T +H+AVIH+   ++     LL     D+        ++ LHLAV  
Sbjct: 199 QLEAENY---EGHTPLHVAVIHKDVEMV----RLLRDAGADLDKPEPTCGRSPLHLAVEA 251

Query: 305 DQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCL-LEGRPEP 353
                +  L+  GA+ A +   G T L  A  R +   AR L   G PEP
Sbjct: 252 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEP 301


>gi|48928017 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, beta isoform b [Homo sapiens]
          Length = 306

 Score =  113 bits (282), Expect = 5e-25
 Identities = 72/194 (37%), Positives = 99/194 (51%), Gaps = 37/194 (19%)

Query: 285 EVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACAR 344
           E +D+QN+L QTALHLA  L +   V  L   GA   + +R G TALH+AC+    ACAR
Sbjct: 53  EYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACAR 112

Query: 345 CLLEGRPEPGR---------------GTSHS----------------------LDLQLQN 367
            LL+ RP   R                T+H+                      L L+ +N
Sbjct: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172

Query: 368 WQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAG 427
           ++G   LH+A + K+  ++ LL   GAD+D  E T G++ LHLAVE Q   +++ LL+AG
Sbjct: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232

Query: 428 AQVDARMLNGCTPL 441
           A   ARM  G TPL
Sbjct: 233 ANPAARMYGGRTPL 246



 Score = 35.8 bits (81), Expect = 0.093
 Identities = 36/110 (32%), Positives = 50/110 (45%), Gaps = 11/110 (10%)

Query: 248 QLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQN---NLYQTALHLAVHL 304
           QLEA  Y   +G T +H+AVIH+   ++     LL     D+        ++ LHLAV  
Sbjct: 167 QLEAENY---EGHTPLHVAVIHKDVEMV----RLLRDAGADLDKPEPTCGRSPLHLAVEA 219

Query: 305 DQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCL-LEGRPEP 353
                +  L+  GA+ A +   G T L  A  R +   AR L   G PEP
Sbjct: 220 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEP 269


>gi|53832024 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, zeta isoform b [Homo sapiens]
          Length = 618

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 80/260 (30%), Positives = 122/260 (46%), Gaps = 39/260 (15%)

Query: 258 DGDTLVHLAVIHEAPAV-LLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLK 316
           DGDT +H+AV     A+  +    +    +LDI+ +  Q+A  +AV  +Q   V+ LV  
Sbjct: 343 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 402

Query: 317 GASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHI 376
           GA     D  G T LHV  ++ H    + + +G      G++  +DL+  N+ GL  LH 
Sbjct: 403 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAV----GSNQFVDLEATNYDGLTPLHC 458

Query: 377 AT---------LQKNQP-----LMELLLRN-------------GADIDVQEGTSGKTALH 409
           A          LQ+NQ      + ELLL+N             GA ++ ++  SG+TALH
Sbjct: 459 AVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALH 518

Query: 410 LAVETQERGLVQFLLQAG---AQVDARMLNGCTPLHLAAGRGL----MGISSTLCKAGAD 462
           LA E     L++  L+     + V+A+  NG T LH+AA        +     L + GAD
Sbjct: 519 LAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGAD 578

Query: 463 SLLRNVEDETPQDLTEESLV 482
              RN+E+E P  L  +  V
Sbjct: 579 PSTRNLENEQPVHLVPDGPV 598


>gi|13899229 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, zeta isoform a [Homo sapiens]
          Length = 718

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 80/260 (30%), Positives = 122/260 (46%), Gaps = 39/260 (15%)

Query: 258 DGDTLVHLAVIHEAPAV-LLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLK 316
           DGDT +H+AV     A+  +    +    +LDI+ +  Q+A  +AV  +Q   V+ LV  
Sbjct: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502

Query: 317 GASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHI 376
           GA     D  G T LHV  ++ H    + + +G      G++  +DL+  N+ GL  LH 
Sbjct: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAV----GSNQFVDLEATNYDGLTPLHC 558

Query: 377 AT---------LQKNQP-----LMELLLRN-------------GADIDVQEGTSGKTALH 409
           A          LQ+NQ      + ELLL+N             GA ++ ++  SG+TALH
Sbjct: 559 AVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALH 618

Query: 410 LAVETQERGLVQFLLQAG---AQVDARMLNGCTPLHLAAGRGL----MGISSTLCKAGAD 462
           LA E     L++  L+     + V+A+  NG T LH+AA        +     L + GAD
Sbjct: 619 LAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGAD 678

Query: 463 SLLRNVEDETPQDLTEESLV 482
              RN+E+E P  L  +  V
Sbjct: 679 PSTRNLENEQPVHLVPDGPV 698


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 60/204 (29%), Positives = 99/204 (48%), Gaps = 13/204 (6%)

Query: 276 LCCLALLPQEVLDIQN--NLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHV 333
           L C+ LL Q  + + +  N Y TALH+A H       + L+ K A+   +  +G T LH+
Sbjct: 347 LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406

Query: 334 ACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNG 393
           AC++  +     LL+          H   +Q     GL  +H+A    +  ++  L+ +G
Sbjct: 407 ACKKNRIKVMELLLK----------HGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456

Query: 394 ADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGIS 453
           A  +      G+TALH+A  + +  +V++L+Q GAQV+A+  +  TPLH++A  G   I 
Sbjct: 457 ASPNTTN-VRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515

Query: 454 STLCKAGADSLLRNVEDETPQDLT 477
             L + GA          TP  L+
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLS 539



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 56/169 (33%), Positives = 80/169 (47%), Gaps = 11/169 (6%)

Query: 295 QTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG 354
           QT LH++  L +   V+ L+ +GAS       G T LH++ +  H   A  LL+      
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLD------ 553

Query: 355 RGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVET 414
               H   L +   +G   LH+A       +  LLL+  A  D   G SG T LH+A   
Sbjct: 554 ----HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAA-GKSGLTPLHVAAHY 608

Query: 415 QERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADS 463
             + +   LL  GA   A   NG TPLH+AA +  M I++TL + GAD+
Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA 657



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 63/219 (28%), Positives = 92/219 (42%), Gaps = 24/219 (10%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH+A H D       L+ +GAS     ++G T LH+A ++  +  A  LLE   +   
Sbjct: 600 TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA 659

Query: 356 GTSHSL-----------------------DLQLQNWQGLACLHIATLQKNQPLMELLLRN 392
            T   +                       ++ L N  GL  LH+A  +    + E+L+  
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ 719

Query: 393 GADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGI 452
           GA +D Q    G T LH+        +V FLLQ  A+V+A+  NG TPLH AA +G   I
Sbjct: 720 GAHVDAQT-KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 778

Query: 453 SSTLCKAGADSLLRNVEDETPQDLTEESLVLLPFDDLKI 491
            + L +  A      V   T   +      +   D LKI
Sbjct: 779 INVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKI 817



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 76/245 (31%), Positives = 106/245 (43%), Gaps = 35/245 (14%)

Query: 249 LEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEV-LDIQNNLYQTALHLAVHLDQP 307
           L AL   S++G    H+ V+ E          LL +E  +D       TALH+A    Q 
Sbjct: 75  LNALHLASKEG----HVEVVSE----------LLQREANVDAATKKGNTALHIASLAGQA 120

Query: 308 GAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEG------RPEPG------- 354
             V+ LV  GA+   Q ++G T L++A Q  HL   + LL+         E G       
Sbjct: 121 EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180

Query: 355 --RGTSHSLDLQLQN-WQG---LACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTAL 408
             +G    + L L+N  +G   L  LHIA  + +     LLL+N  + DV E  SG T L
Sbjct: 181 LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV-ESKSGFTPL 239

Query: 409 HLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNV 468
           H+A       +   LL   A VD    N  TPLH+A+ RG   +   L   GA    +  
Sbjct: 240 HIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTR 299

Query: 469 EDETP 473
           +  TP
Sbjct: 300 DGLTP 304



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 51/185 (27%), Positives = 84/185 (45%), Gaps = 11/185 (5%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH          V  L+ + A    + ++G + LH+A Q  HL C + LL+       
Sbjct: 303 TPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ------- 355

Query: 356 GTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ 415
              H++ +       L  LH+A    +  + ++LL   A+ + +   +G T LH+A +  
Sbjct: 356 ---HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK-ALNGFTPLHIACKKN 411

Query: 416 ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQD 475
              +++ LL+ GA + A   +G TP+H+AA  G + I S L   GA     NV  ET   
Sbjct: 412 RIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALH 471

Query: 476 LTEES 480
           +   S
Sbjct: 472 MAARS 476



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 43/157 (27%), Positives = 74/157 (47%), Gaps = 11/157 (7%)

Query: 288 DIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLL 347
           D +  +   ALH+A   D   A   L+    +  ++ + G T LH+A    ++  A  LL
Sbjct: 196 DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255

Query: 348 EGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTA 407
                     + ++D   +N   +  LH+A+ + N  +++LLL  GA ID +    G T 
Sbjct: 256 N--------RAAAVDFTARN--DITPLHVASKRGNANMVKLLLDRGAKIDAKT-RDGLTP 304

Query: 408 LHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLA 444
           LH    +    +V+ LL   A + ++  NG +PLH+A
Sbjct: 305 LHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMA 341



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 36/115 (31%), Positives = 61/115 (53%), Gaps = 1/115 (0%)

Query: 359 HSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERG 418
           + +D+ + N  GL  LH+A+ + +  ++  LL+  A++D      G TALH+A    +  
Sbjct: 63  NGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAAT-KKGNTALHIASLAGQAE 121

Query: 419 LVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           +V+ L+  GA V+A+  NG TPL++AA    + +   L   GA   L   +  TP
Sbjct: 122 VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTP 176



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 56/214 (26%), Positives = 87/214 (40%), Gaps = 44/214 (20%)

Query: 290 QNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEG 349
           QN L   ALHLA        V  L+ + A+     + G+TALH+A         + L+  
Sbjct: 72  QNGL--NALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLV-- 127

Query: 350 RPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGAD-------------I 396
                   ++  ++  Q+  G   L++A  + +  +++ LL NGA              +
Sbjct: 128 --------TNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAV 179

Query: 397 DVQEG------------TSGKT---ALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPL 441
            +Q+G            T GK    ALH+A    +      LLQ     D    +G TPL
Sbjct: 180 ALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPL 239

Query: 442 HLAAGRGLMGISSTLCK--AGADSLLRNVEDETP 473
           H+AA  G + +++ L    A  D   RN  D TP
Sbjct: 240 HIAAHYGNINVATLLLNRAAAVDFTARN--DITP 271



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 44/157 (28%), Positives = 68/157 (43%), Gaps = 13/157 (8%)

Query: 255 ISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALV 314
           ++  G   VHLA   +   V +  L L     +++ N    T LHLA   D+      LV
Sbjct: 660 VTRQGIASVHLAA--QEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717

Query: 315 LKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACL 374
            +GA    Q + G T LHV C   ++     LL+          HS  +  +   G   L
Sbjct: 718 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ----------HSAKVNAKTKNGYTPL 767

Query: 375 HIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLA 411
           H A  Q +  ++ +LL+N A  + +   +G TAL +A
Sbjct: 768 HQAAQQGHTHIINVLLQNNASPN-ELTVNGNTALGIA 803


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 76/249 (30%), Positives = 110/249 (44%), Gaps = 42/249 (16%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVL 315
           S+DG TL+H A       VL   +  L    LD  + L +TA H A    Q  A+  LV 
Sbjct: 121 SKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVG 180

Query: 316 KGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLH 375
            G    ++D+ G+TALH+A  R H+A  + L++            LDL+ QN +GL  LH
Sbjct: 181 SGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD----------IGLDLEEQNAEGLTALH 230

Query: 376 IATLQKNQPLMELLLRNGADIDV--QEGTS------------------------------ 403
            A    +   ++LLLR G+ ++   Q+  S                              
Sbjct: 231 SAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQ 290

Query: 404 GKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADS 463
           G + LHLAV      LV+ L+ + + V+A      TPLHLAA      I+  L  AG D 
Sbjct: 291 GASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDL 350

Query: 464 LLRNVEDET 472
            LR+ + +T
Sbjct: 351 NLRDKQGKT 359



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 53/209 (25%), Positives = 82/209 (39%), Gaps = 34/209 (16%)

Query: 298 LHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGR----PEP 353
           LH A   +  G ++ L+ +  +   ++  G  ALH A    H    R LLE       E 
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 354 GRGT-------------------SHSLDLQL----------QNWQGLACLHIATLQKNQP 384
             G                     H   LQ+          ++  GL  LH A  + + P
Sbjct: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138

Query: 385 LMELLLRNGADIDVQE-GTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHL 443
           ++  ++ +  D+ +      G+TA H A E  +   + FL+ +G   + +   G T LHL
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198

Query: 444 AAGRGLMGISSTLCKAGADSLLRNVEDET 472
           AAGRG M +   L   G D   +N E  T
Sbjct: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLT 227



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 37/137 (27%), Positives = 63/137 (45%), Gaps = 13/137 (9%)

Query: 290 QNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEG 349
           Q NL  + LH A         R L+  G    + D  G + LH+A +    A  R L+  
Sbjct: 256 QKNL--SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313

Query: 350 RPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALH 409
             +      +++D + Q       LH+A     Q + ++LL  G D+++++   GKTAL 
Sbjct: 314 DSDV-----NAVDNRQQT-----PLHLAAEHAWQDIADMLLIAGVDLNLRD-KQGKTALA 362

Query: 410 LAVETQERGLVQFLLQA 426
           +AV +    LV  +++A
Sbjct: 363 VAVRSNHVSLVDMIIKA 379



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 27/94 (28%), Positives = 46/94 (48%), Gaps = 2/94 (2%)

Query: 255 ISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALV 314
           +   G + +HLAV H  PA++   L +     ++  +N  QT LHLA           L+
Sbjct: 287 VDHQGASPLHLAVRHNFPALVR--LLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLL 344

Query: 315 LKGASRALQDRHGDTALHVACQRQHLACARCLLE 348
           + G    L+D+ G TAL VA +  H++    +++
Sbjct: 345 IAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378


>gi|41281709 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, delta [Homo sapiens]
          Length = 313

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 91/277 (32%), Positives = 121/277 (43%), Gaps = 44/277 (15%)

Query: 232 PAPRLPLP--HVGALSPQQLEALTYISEDGDTLVHLAVIHEAP-AVLLCCLALLPQEVLD 288
           P P L +   H+ AL PQQL A     E+GDTL+HL        A       L     LD
Sbjct: 23  PGPSLEVARAHMLALGPQQLLAQ---DEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLD 79

Query: 289 IQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLE 348
           I+ +  +T L +A   +QP  V  L+  GA     D  G + LHVA        A   L 
Sbjct: 80  IREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVA--------ATYGLP 131

Query: 349 GRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPL--------------------MEL 388
           G       +   +DL+ ++++GL  LH A L  N  +                    + +
Sbjct: 132 GVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHM 191

Query: 389 LLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARML-----NGCTPLHL 443
           LL+ GA+   QE  S KT LHLAV+     LVQ LL+   + D R       +G T LH+
Sbjct: 192 LLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLEL-PRGDLRTFVNMKAHGNTALHM 250

Query: 444 AA----GRGLMGISSTLCKAGADSLLRNVEDETPQDL 476
           AA    G     I   L  AGAD  LRN+E+E P  L
Sbjct: 251 AAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 67/221 (30%), Positives = 104/221 (47%), Gaps = 13/221 (5%)

Query: 259 GDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGA 318
           G+T +H+A       V+ C L      ++D +    QT LH+A  L +   V+ L+   A
Sbjct: 443 GETALHMAARAGQVEVVRCLLR--NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 500

Query: 319 SRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIAT 378
                  +G T LH++ +   +  A  LLE       G +HSL  +    +G   LH+A 
Sbjct: 501 HPDAATTNGYTPLHISAREGQVDVASVLLEA------GAAHSLATK----KGFTPLHVAA 550

Query: 379 LQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGC 438
              +  + +LLL+  A  D   G +G T LH+A     + +   LL+ GA   A   NG 
Sbjct: 551 KYGSLDVAKLLLQRRAAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 609

Query: 439 TPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEE 479
           TPLH+AA +  M I+STL   GA++ +   +  TP  L  +
Sbjct: 610 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 650



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 68/251 (27%), Positives = 105/251 (41%), Gaps = 13/251 (5%)

Query: 241 VGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHL 300
           V  L  Q+  A     ++G T +H+A  ++   V L  L          +N    T LH+
Sbjct: 557 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY--TPLHI 614

Query: 301 AVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHS 360
           A   +Q      L+  GA   +  + G T LH+A Q  H      LL+            
Sbjct: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD----------KG 664

Query: 361 LDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLV 420
            ++ +    GL  LH+A  +    + ++L ++GAD D      G T L +A       +V
Sbjct: 665 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKL-GYTPLIVACHYGNVKMV 723

Query: 421 QFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEES 480
            FLL+ GA V+A+  NG TPLH AA +G   I + L + GA          T   + +  
Sbjct: 724 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 783

Query: 481 LVLLPFDDLKI 491
             +   D LK+
Sbjct: 784 GYISVVDTLKV 794



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 68/247 (27%), Positives = 107/247 (43%), Gaps = 34/247 (13%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDI--QNNLYQTALHLAVHLDQPGAVRAL 313
           ++ G+T +H+A +     V+     +L +E  +I  Q+    T L++A   +    V+ L
Sbjct: 73  TKKGNTALHIASLAGQAEVV----KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 314 VLKGASRALQDRHGDTALHVACQRQHLACARCLLEG---------------RPEPGRGTS 358
           +  GA+++     G T L VA Q+ H      LLE                R +  +  +
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 188

Query: 359 ------HSLDLQLQNW------QGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKT 406
                 H+ D+Q +         G   LHIA    N  +  LLL  GA +D     +G T
Sbjct: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT-ARNGIT 247

Query: 407 ALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLR 466
            LH+A +     +V+ LL  G Q+DA+  +G TPLH AA  G   +   L + GA  L R
Sbjct: 248 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 307

Query: 467 NVEDETP 473
                +P
Sbjct: 308 TKNGLSP 314



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 59/201 (29%), Positives = 86/201 (42%), Gaps = 24/201 (11%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG- 354
           T LH A        V  L+ +GA    + ++G + LH+A Q  H+ C + LL+ +     
Sbjct: 280 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 339

Query: 355 ------------------RGTSHSLDLQL----QNWQGLACLHIATLQKNQPLMELLLRN 392
                             R T   LD +     +   G   LHIA  +    +MELL++ 
Sbjct: 340 VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 399

Query: 393 GADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGI 452
           GA I      SG T +H+A       +V  LLQ GA  D   + G T LH+AA  G + +
Sbjct: 400 GASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV 458

Query: 453 SSTLCKAGADSLLRNVEDETP 473
              L + GA    R  E++TP
Sbjct: 459 VRCLLRNGALVDARAREEQTP 479



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 67/243 (27%), Positives = 94/243 (38%), Gaps = 61/243 (25%)

Query: 290 QNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHV---------------- 333
           QN L   ALHLA      G V+ L+ +G+S     + G+TALH+                
Sbjct: 41  QNGL--NALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 98

Query: 334 -----------------ACQRQHLACARCLLEG------RPEPG---------RGTSHSL 361
                            A Q  H+   + LLE         E G         +G + ++
Sbjct: 99  GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 158

Query: 362 DLQLQN-WQG---LACLHIATLQKNQPLMELLLRNGADIDVQE-------GTSGKTALHL 410
            + L+N  +G   L  LHIA  + +     LLL+N  + DVQ          SG T LH+
Sbjct: 159 AILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218

Query: 411 AVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVED 470
           A       +   LL  GA VD    NG TPLH+A+ RG   +   L   G     +  + 
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278

Query: 471 ETP 473
            TP
Sbjct: 279 LTP 281



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 31/84 (36%), Positives = 43/84 (51%), Gaps = 1/84 (1%)

Query: 390 LRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGL 449
           L+ G DI+     +G  ALHLA +    GLVQ LL  G+ VD+    G T LH+A+  G 
Sbjct: 30  LKGGIDINTCN-QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQ 88

Query: 450 MGISSTLCKAGADSLLRNVEDETP 473
             +   L K GA+   ++    TP
Sbjct: 89  AEVVKVLVKEGANINAQSQNGFTP 112


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 67/221 (30%), Positives = 104/221 (47%), Gaps = 13/221 (5%)

Query: 259 GDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGA 318
           G+T +H+A       V+ C L      ++D +    QT LH+A  L +   V+ L+   A
Sbjct: 464 GETALHMAARAGQVEVVRCLLR--NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521

Query: 319 SRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIAT 378
                  +G T LH++ +   +  A  LLE       G +HSL  +    +G   LH+A 
Sbjct: 522 HPDAATTNGYTPLHISAREGQVDVASVLLEA------GAAHSLATK----KGFTPLHVAA 571

Query: 379 LQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGC 438
              +  + +LLL+  A  D   G +G T LH+A     + +   LL+ GA   A   NG 
Sbjct: 572 KYGSLDVAKLLLQRRAAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 630

Query: 439 TPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEE 479
           TPLH+AA +  M I+STL   GA++ +   +  TP  L  +
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 68/251 (27%), Positives = 105/251 (41%), Gaps = 13/251 (5%)

Query: 241 VGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHL 300
           V  L  Q+  A     ++G T +H+A  ++   V L  L          +N    T LH+
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY--TPLHI 635

Query: 301 AVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHS 360
           A   +Q      L+  GA   +  + G T LH+A Q  H      LL+            
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD----------KG 685

Query: 361 LDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLV 420
            ++ +    GL  LH+A  +    + ++L ++GAD D      G T L +A       +V
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKL-GYTPLIVACHYGNVKMV 744

Query: 421 QFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEES 480
            FLL+ GA V+A+  NG TPLH AA +G   I + L + GA          T   + +  
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 804

Query: 481 LVLLPFDDLKI 491
             +   D LK+
Sbjct: 805 GYISVVDTLKV 815



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 68/247 (27%), Positives = 107/247 (43%), Gaps = 34/247 (13%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDI--QNNLYQTALHLAVHLDQPGAVRAL 313
           ++ G+T +H+A +     V+     +L +E  +I  Q+    T L++A   +    V+ L
Sbjct: 94  TKKGNTALHIASLAGQAEVV----KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 314 VLKGASRALQDRHGDTALHVACQRQHLACARCLLEG---------------RPEPGRGTS 358
           +  GA+++     G T L VA Q+ H      LLE                R +  +  +
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209

Query: 359 ------HSLDLQLQNW------QGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKT 406
                 H+ D+Q +         G   LHIA    N  +  LLL  GA +D     +G T
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT-ARNGIT 268

Query: 407 ALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLR 466
            LH+A +     +V+ LL  G Q+DA+  +G TPLH AA  G   +   L + GA  L R
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328

Query: 467 NVEDETP 473
                +P
Sbjct: 329 TKNGLSP 335



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 59/201 (29%), Positives = 86/201 (42%), Gaps = 24/201 (11%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG- 354
           T LH A        V  L+ +GA    + ++G + LH+A Q  H+ C + LL+ +     
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 360

Query: 355 ------------------RGTSHSLDLQL----QNWQGLACLHIATLQKNQPLMELLLRN 392
                             R T   LD +     +   G   LHIA  +    +MELL++ 
Sbjct: 361 VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420

Query: 393 GADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGI 452
           GA I      SG T +H+A       +V  LLQ GA  D   + G T LH+AA  G + +
Sbjct: 421 GASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV 479

Query: 453 SSTLCKAGADSLLRNVEDETP 473
              L + GA    R  E++TP
Sbjct: 480 VRCLLRNGALVDARAREEQTP 500



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 67/243 (27%), Positives = 94/243 (38%), Gaps = 61/243 (25%)

Query: 290 QNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHV---------------- 333
           QN L   ALHLA      G V+ L+ +G+S     + G+TALH+                
Sbjct: 62  QNGL--NALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119

Query: 334 -----------------ACQRQHLACARCLLEG------RPEPG---------RGTSHSL 361
                            A Q  H+   + LLE         E G         +G + ++
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 179

Query: 362 DLQLQN-WQG---LACLHIATLQKNQPLMELLLRNGADIDVQE-------GTSGKTALHL 410
            + L+N  +G   L  LHIA  + +     LLL+N  + DVQ          SG T LH+
Sbjct: 180 AILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 411 AVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVED 470
           A       +   LL  GA VD    NG TPLH+A+ RG   +   L   G     +  + 
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299

Query: 471 ETP 473
            TP
Sbjct: 300 LTP 302



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 31/84 (36%), Positives = 43/84 (51%), Gaps = 1/84 (1%)

Query: 390 LRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGL 449
           L+ G DI+     +G  ALHLA +    GLVQ LL  G+ VD+    G T LH+A+  G 
Sbjct: 51  LKGGIDINTCN-QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQ 109

Query: 450 MGISSTLCKAGADSLLRNVEDETP 473
             +   L K GA+   ++    TP
Sbjct: 110 AEVVKVLVKEGANINAQSQNGFTP 133


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 67/221 (30%), Positives = 104/221 (47%), Gaps = 13/221 (5%)

Query: 259 GDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGA 318
           G+T +H+A       V+ C L      ++D +    QT LH+A  L +   V+ L+   A
Sbjct: 464 GETALHMAARAGQVEVVRCLLR--NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521

Query: 319 SRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIAT 378
                  +G T LH++ +   +  A  LLE       G +HSL  +    +G   LH+A 
Sbjct: 522 HPDAATTNGYTPLHISAREGQVDVASVLLEA------GAAHSLATK----KGFTPLHVAA 571

Query: 379 LQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGC 438
              +  + +LLL+  A  D   G +G T LH+A     + +   LL+ GA   A   NG 
Sbjct: 572 KYGSLDVAKLLLQRRAAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 630

Query: 439 TPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEE 479
           TPLH+AA +  M I+STL   GA++ +   +  TP  L  +
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 68/251 (27%), Positives = 105/251 (41%), Gaps = 13/251 (5%)

Query: 241 VGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHL 300
           V  L  Q+  A     ++G T +H+A  ++   V L  L          +N    T LH+
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY--TPLHI 635

Query: 301 AVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHS 360
           A   +Q      L+  GA   +  + G T LH+A Q  H      LL+            
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD----------KG 685

Query: 361 LDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLV 420
            ++ +    GL  LH+A  +    + ++L ++GAD D      G T L +A       +V
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKL-GYTPLIVACHYGNVKMV 744

Query: 421 QFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEES 480
            FLL+ GA V+A+  NG TPLH AA +G   I + L + GA          T   + +  
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 804

Query: 481 LVLLPFDDLKI 491
             +   D LK+
Sbjct: 805 GYISVVDTLKV 815



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 68/247 (27%), Positives = 107/247 (43%), Gaps = 34/247 (13%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDI--QNNLYQTALHLAVHLDQPGAVRAL 313
           ++ G+T +H+A +     V+     +L +E  +I  Q+    T L++A   +    V+ L
Sbjct: 94  TKKGNTALHIASLAGQAEVV----KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 314 VLKGASRALQDRHGDTALHVACQRQHLACARCLLEG---------------RPEPGRGTS 358
           +  GA+++     G T L VA Q+ H      LLE                R +  +  +
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209

Query: 359 ------HSLDLQLQNW------QGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKT 406
                 H+ D+Q +         G   LHIA    N  +  LLL  GA +D     +G T
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT-ARNGIT 268

Query: 407 ALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLR 466
            LH+A +     +V+ LL  G Q+DA+  +G TPLH AA  G   +   L + GA  L R
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328

Query: 467 NVEDETP 473
                +P
Sbjct: 329 TKNGLSP 335



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 59/201 (29%), Positives = 86/201 (42%), Gaps = 24/201 (11%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG- 354
           T LH A        V  L+ +GA    + ++G + LH+A Q  H+ C + LL+ +     
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 360

Query: 355 ------------------RGTSHSLDLQL----QNWQGLACLHIATLQKNQPLMELLLRN 392
                             R T   LD +     +   G   LHIA  +    +MELL++ 
Sbjct: 361 VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420

Query: 393 GADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGI 452
           GA I      SG T +H+A       +V  LLQ GA  D   + G T LH+AA  G + +
Sbjct: 421 GASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV 479

Query: 453 SSTLCKAGADSLLRNVEDETP 473
              L + GA    R  E++TP
Sbjct: 480 VRCLLRNGALVDARAREEQTP 500



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 67/243 (27%), Positives = 94/243 (38%), Gaps = 61/243 (25%)

Query: 290 QNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHV---------------- 333
           QN L   ALHLA      G V+ L+ +G+S     + G+TALH+                
Sbjct: 62  QNGL--NALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119

Query: 334 -----------------ACQRQHLACARCLLEG------RPEPG---------RGTSHSL 361
                            A Q  H+   + LLE         E G         +G + ++
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 179

Query: 362 DLQLQN-WQG---LACLHIATLQKNQPLMELLLRNGADIDVQE-------GTSGKTALHL 410
            + L+N  +G   L  LHIA  + +     LLL+N  + DVQ          SG T LH+
Sbjct: 180 AILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 411 AVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVED 470
           A       +   LL  GA VD    NG TPLH+A+ RG   +   L   G     +  + 
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299

Query: 471 ETP 473
            TP
Sbjct: 300 LTP 302



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 31/84 (36%), Positives = 43/84 (51%), Gaps = 1/84 (1%)

Query: 390 LRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGL 449
           L+ G DI+     +G  ALHLA +    GLVQ LL  G+ VD+    G T LH+A+  G 
Sbjct: 51  LKGGIDINTCN-QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQ 109

Query: 450 MGISSTLCKAGADSLLRNVEDETP 473
             +   L K GA+   ++    TP
Sbjct: 110 AEVVKVLVKEGANINAQSQNGFTP 133


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 64/222 (28%), Positives = 97/222 (43%), Gaps = 17/222 (7%)

Query: 257 EDGDTLVHLAVI--HEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALV 314
           + G+  +H+A    H   A LLC     P    +IQ+   +T LH A         +AL 
Sbjct: 443 KSGEMALHVAARYGHADVAQLLCSFGSNP----NIQDKEEETPLHCAAWHGYYSVAKALC 498

Query: 315 LKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACL 374
             G +  +++R G+T L  A  R +     CL E          H  DL   +  G   L
Sbjct: 499 EAGCNVNIKNREGETPLLTASARGYHDIVECLAE----------HGADLNACDKDGHIAL 548

Query: 375 HIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARM 434
           H+A  +    +++ LL  G  +D Q+   G T LH+A +     +V  L +A   +D   
Sbjct: 549 HLAVRRCQMEVIKTLLSQGCFVDYQD-RHGNTPLHVACKDGNMPIVVALCEANCNLDISN 607

Query: 435 LNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDL 476
             G TPLHLAA  G++ +   LC  GA       + +T +DL
Sbjct: 608 KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL 649



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 55/197 (27%), Positives = 94/197 (47%), Gaps = 11/197 (5%)

Query: 287 LDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCL 346
           LD+++   + ALH+A         + L   G++  +QD+  +T LH A    + + A+ L
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497

Query: 347 LEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKT 406
            E             ++ ++N +G   L  A+ +    ++E L  +GAD++  +   G  
Sbjct: 498 CEA----------GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACD-KDGHI 546

Query: 407 ALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLR 466
           ALHLAV   +  +++ LL  G  VD +  +G TPLH+A   G M I   LC+A  +  + 
Sbjct: 547 ALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDIS 606

Query: 467 NVEDETPQDLTEESLVL 483
           N    TP  L   + +L
Sbjct: 607 NKYGRTPLHLAANNGIL 623



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 46/191 (24%), Positives = 88/191 (46%), Gaps = 13/191 (6%)

Query: 285 EVLDIQNNLYQTALHLAVHLDQPGAVRALV--LKGASRALQDRHGDTALHVACQRQHLAC 342
           + LD +++    A+  A++ D    ++ L+  L        ++HG   L +A    ++  
Sbjct: 335 DTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQI 394

Query: 343 ARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGT 402
            + L++      RG+     + +Q+  G   ++ A    +   ++ L  N   +DV++  
Sbjct: 395 LQLLIK------RGSR----IDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKD-K 443

Query: 403 SGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGAD 462
           SG+ ALH+A       + Q L   G+  + +     TPLH AA  G   ++  LC+AG +
Sbjct: 444 SGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCN 503

Query: 463 SLLRNVEDETP 473
             ++N E ETP
Sbjct: 504 VNIKNREGETP 514



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 36/104 (34%), Positives = 44/104 (42%), Gaps = 4/104 (3%)

Query: 254 YISEDGDTLVHLAVIH-EAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRA 312
           Y    G+T +H+A      P V+  C A      LDI N   +T LHLA +      VR 
Sbjct: 572 YQDRHGNTPLHVACKDGNMPIVVALCEANCN---LDISNKYGRTPLHLAANNGILDVVRY 628

Query: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRG 356
           L L GAS       G TA  +A   QH   A  L   R +  RG
Sbjct: 629 LCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRG 672


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 62/179 (34%), Positives = 84/179 (46%), Gaps = 11/179 (6%)

Query: 298 LHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGT 357
           LH A      G  R L+  GA    Q+R G T LH+A Q      AR L+  + +P    
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPN--- 488

Query: 358 SHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQER 417
                  L   +G   LH+A    +  L++LL   GA++D Q+    +T LHLAVE  + 
Sbjct: 489 -------LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL-RTPLHLAVERGKV 540

Query: 418 GLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDL 476
             +Q LL++GA  DA   +G  PLH AA RG   I   L + GA   L   +  TP  L
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 61/182 (33%), Positives = 80/182 (43%), Gaps = 12/182 (6%)

Query: 281 LLPQEV-LDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQH 339
           LL  EV +D Q     T L +A    QP     L+  GA     D  G   LH A Q   
Sbjct: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440

Query: 340 LACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQ 399
              AR LL+          H   +  Q  +G   LH+A     + +  LL+   AD ++ 
Sbjct: 441 DGTARLLLD----------HGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH 490

Query: 400 EGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKA 459
           E   GKT LH+A       LV+ L   GA++DA+  N  TPLHLA  RG +     L K+
Sbjct: 491 EA-EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549

Query: 460 GA 461
           GA
Sbjct: 550 GA 551



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 73/227 (32%), Positives = 92/227 (40%), Gaps = 44/227 (19%)

Query: 287 LDIQNNLYQTALHLAV---------HLDQPGAV------------------------RAL 313
           LD Q    +T LHLAV         HL + GAV                        + L
Sbjct: 520 LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKML 579

Query: 314 VLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLAC 373
           +  GAS  L    G T LH+A  + HL     L E     G        L   NW  L  
Sbjct: 580 LRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA-------LGAVNWTPL-- 630

Query: 374 LHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDAR 433
            H+A     + ++  LL+ GAD +  E  SG T LHLAV+      V  LL+  A V AR
Sbjct: 631 -HLAARHGEEAVVSALLQCGADPNAAE-QSGWTPLHLAVQRSTFLSVINLLEHHANVHAR 688

Query: 434 MLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEES 480
              G TP HLAA +G   I   L +AGA   +++    TP  L   S
Sbjct: 689 NKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS 735



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 70/255 (27%), Positives = 105/255 (41%), Gaps = 21/255 (8%)

Query: 230 EDPAPRLPLPHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDI 289
           +D   RL L H   +  Q+ E        G T +HLA  +    V    L +  Q   ++
Sbjct: 440 DDGTARLLLDHGACVDAQERE--------GWTPLHLAAQNNFENVAR--LLVSRQADPNL 489

Query: 290 QNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEG 349
                +T LH+A +      V+ L  +GA    Q R+  T LH+A +R  +   + LL+ 
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549

Query: 350 RPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALH 409
              P      +LD       G   LH A  +    + ++LLR GA +++     G T LH
Sbjct: 550 GAVPD-----ALDQS-----GYGPLHTAAARGKYLICKMLLRYGASLELPTH-QGWTPLH 598

Query: 410 LAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVE 469
           LA       ++  L ++ A + A      TPLHLAA  G   + S L + GAD       
Sbjct: 599 LAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQS 658

Query: 470 DETPQDLTEESLVLL 484
             TP  L  +    L
Sbjct: 659 GWTPLHLAVQRSTFL 673



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 41/116 (35%), Positives = 55/116 (47%), Gaps = 1/116 (0%)

Query: 358 SHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQER 417
           +H +D+  Q   G   L IA   +   L  LLL +GAD + +    G   LH A +  + 
Sbjct: 383 AHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN-RVDEDGWAPLHFAAQNGDD 441

Query: 418 GLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           G  + LL  GA VDA+   G TPLHLAA      ++  L    AD  L   E +TP
Sbjct: 442 GTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTP 497



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 35/107 (32%), Positives = 48/107 (44%), Gaps = 1/107 (0%)

Query: 374 LHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDAR 433
           LH    Q +   + LLL +  D+D Q   SG T L +A + Q+  L   LL  GA  +  
Sbjct: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQTA-SGYTPLLIAAQDQQPDLCALLLAHGADANRV 424

Query: 434 MLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEES 480
             +G  PLH AA  G  G +  L   GA    +  E  TP  L  ++
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQN 471


>gi|30348954 mindbomb homolog 1 [Homo sapiens]
          Length = 1006

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 69/217 (31%), Positives = 104/217 (47%), Gaps = 34/217 (15%)

Query: 257 EDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDI--QNNLYQTALHLAVHLDQPGAVRALV 314
           +DGD  VH A   +  AV+     +L +   D+  +N   QT LH+AV+      V+ L+
Sbjct: 495 KDGDRAVHHAAFGDEGAVI----EVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLL 550

Query: 315 LKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG---------------RGTSH 359
             G   +LQD  GDT LH A  ++       LLE   +                 RG   
Sbjct: 551 DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610

Query: 360 SLDLQLQN----W-------QGLACLHIATLQKNQPLMELLLRNG-ADIDVQEGTSGKTA 407
           ++ + L      W        G   LH+A L  +  + ELL+  G A++D+Q   + +TA
Sbjct: 611 AMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQ-NVNQQTA 669

Query: 408 LHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLA 444
           LHLAVE Q   +V+ L++AGA++D +  +G TPLH A
Sbjct: 670 LHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 66/228 (28%), Positives = 88/228 (38%), Gaps = 42/228 (18%)

Query: 257 EDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLK 316
           +DG T +HLA ++    V    L       LDIQN   QTALHLAV       VR LV  
Sbjct: 630 DDGYTALHLAALNNHVEVAEL-LVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRA 688

Query: 317 GASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHI 376
           GA   +QD+ GDT LH A +   L+  R                   QLQ+ Q +  +  
Sbjct: 689 GAKLDIQDKDGDTPLHEALRHHTLSQLR-------------------QLQDMQDVGKVDA 729

Query: 377 A-TLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARML 435
           A    KN  +M L            GT G      A +     +  FL   GA +  R  
Sbjct: 730 AWEPSKNTLIMGL------------GTQG------AEKKSAASIACFLAANGADLSIRNK 771

Query: 436 NGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEESLVL 483
            G +PL L     L      L K   + +   V   +P  ++ +S  L
Sbjct: 772 KGQSPLDLCPDPNL---CKALAKCHKEKVSGQVGSRSPSMISNDSETL 816



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 28/104 (26%), Positives = 53/104 (50%), Gaps = 1/104 (0%)

Query: 370 GLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQ 429
           G   +  A+   +  +++LLL+   D++ ++   G  A+H A    E  +++ L +  A 
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAED-KDGDRAVHHAAFGDEGAVIEVLHRGSAD 522

Query: 430 VDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           ++AR     TPLH+A  +G + +  TL   G    L++ E +TP
Sbjct: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTP 566



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 22/79 (27%), Positives = 36/79 (45%)

Query: 395 DIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISS 454
           D+DV    +G TA+  A +     +++ LL+    V+A   +G   +H AA      +  
Sbjct: 455 DVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIE 514

Query: 455 TLCKAGADSLLRNVEDETP 473
            L +  AD   RN   +TP
Sbjct: 515 VLHRGSADLNARNKRRQTP 533


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 66/221 (29%), Positives = 109/221 (49%), Gaps = 19/221 (8%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQ---EVLDIQNNLYQTALHLAVHLDQPGAVRA 312
           +++G + +H+A    A    L C+ LL Q   E+ DI  + + T LH+A H       + 
Sbjct: 335 TKNGLSPIHMA----AQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKV 389

Query: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLA 372
           L+ KGA    +  +G T LH+AC++ H+     LL+        T  S+D   ++  GL 
Sbjct: 390 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK--------TGASIDAVTES--GLT 439

Query: 373 CLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDA 432
            LH+A+   + P+++ LL+ GA  +V      +T LH+A       + ++LLQ  A+V+A
Sbjct: 440 PLHVASFMGHLPIVKNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNA 498

Query: 433 RMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           +  +  TPLH AA  G   +   L +  A+  L      TP
Sbjct: 499 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 539



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 62/207 (29%), Positives = 89/207 (42%), Gaps = 20/207 (9%)

Query: 286 VLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARC 345
           +L+       TALH+A    Q   VR LV  GA+   Q + G T L++A Q  HL   + 
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162

Query: 346 LLEGRPEPGRGT-------------------SHSLDLQLQNWQGLACLHIATLQKNQPLM 386
           LLE        T                   +H ++   +    L  LHIA    +    
Sbjct: 163 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 222

Query: 387 ELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAG 446
            +LL+N  + DV   T G T LH+A   +   + Q LL  GA V+    NG TPLH+A+ 
Sbjct: 223 AVLLQNDPNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281

Query: 447 RGLMGISSTLCKAGADSLLRNVEDETP 473
           RG + +   L   GA    +  ++ TP
Sbjct: 282 RGNVIMVRLLLDRGAQIETKTKDELTP 308



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 60/196 (30%), Positives = 90/196 (45%), Gaps = 11/196 (5%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH+A   +Q    R+L+  G S   +   G T LH+A Q  H      LL        
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL-------- 688

Query: 356 GTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ 415
             S   +  L N  GL  LH+   + + P+ ++L+++G  +D      G T LH+A    
Sbjct: 689 --SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT-RMGYTPLHVASHYG 745

Query: 416 ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQD 475
              LV+FLLQ  A V+A+   G +PLH AA +G   I + L K GA     + +  TP  
Sbjct: 746 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 805

Query: 476 LTEESLVLLPFDDLKI 491
           + +    +   D LK+
Sbjct: 806 IAKRLGYISVTDVLKV 821



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 58/184 (31%), Positives = 81/184 (44%), Gaps = 11/184 (5%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH+A        V AL+ K AS+A   + G T LHVA +   +  A  LLE    P  
Sbjct: 538 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 597

Query: 356 GTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ 415
              +          GL  LH+A    N  +++LLL  G         +G T LH+A +  
Sbjct: 598 AGKN----------GLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIAAKQN 646

Query: 416 ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQD 475
           +  + + LLQ G   +A  + G TPLHLAA  G   + + L    A+  L N    TP  
Sbjct: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 706

Query: 476 LTEE 479
           L  +
Sbjct: 707 LVAQ 710



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 62/223 (27%), Positives = 105/223 (47%), Gaps = 13/223 (5%)

Query: 251 ALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAV 310
           ++ +  ++G T +H+A       V++  L L     ++ +     T LH A         
Sbjct: 264 SVNFTPQNGITPLHIA--SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321

Query: 311 RALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQG 370
             L+  GA    + ++G + +H+A Q  HL C R LL+   E         D+ L +   
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-------DITLDH--- 371

Query: 371 LACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQV 430
           L  LH+A    +  + ++LL  GA  +     +G T LH+A +     +++ LL+ GA +
Sbjct: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPN-SRALNGFTPLHIACKKNHVRVMELLLKTGASI 430

Query: 431 DARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           DA   +G TPLH+A+  G + I   L + GA   + NV+ ETP
Sbjct: 431 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 473



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 53/185 (28%), Positives = 80/185 (43%), Gaps = 11/185 (5%)

Query: 295 QTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG 354
           QT LH A  +     V+ L+   A+  L    G T LH+A +  H+     LLE      
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563

Query: 355 RGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVET 414
             T           +G   LH+A       + ELLL   A  +   G +G T LH+AV  
Sbjct: 564 CMTK----------KGFTPLHVAAKYGKVRVAELLLERDAHPNAA-GKNGLTPLHVAVHH 612

Query: 415 QERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQ 474
               +V+ LL  G    +   NG TPLH+AA +  + ++ +L + G  +   +V+  TP 
Sbjct: 613 NNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 672

Query: 475 DLTEE 479
            L  +
Sbjct: 673 HLAAQ 677



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 44/156 (28%), Positives = 65/156 (41%), Gaps = 13/156 (8%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVL 315
           S  G T +HLA   E  A ++  L L  Q   ++ N    T LHL            L+ 
Sbjct: 665 SVQGVTPLHLAA-QEGHAEMVALL-LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722

Query: 316 KGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLH 375
            G       R G T LHVA    ++   + LL+          H  D+  +   G + LH
Sbjct: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ----------HQADVNAKTKLGYSPLH 772

Query: 376 IATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLA 411
            A  Q +  ++ LLL+NGA  + +  + G T L +A
Sbjct: 773 QAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIA 807



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 28/86 (32%), Positives = 40/86 (46%), Gaps = 5/86 (5%)

Query: 390 LRNGADIDV--QEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGR 447
           LRNG DI+   Q G +G   LHLA +     +V  LL     ++     G T LH+AA  
Sbjct: 65  LRNGVDINTCNQNGLNG---LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALA 121

Query: 448 GLMGISSTLCKAGADSLLRNVEDETP 473
           G   +   L   GA+   ++ +  TP
Sbjct: 122 GQDEVVRELVNYGANVNAQSQKGFTP 147


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 66/221 (29%), Positives = 109/221 (49%), Gaps = 19/221 (8%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQ---EVLDIQNNLYQTALHLAVHLDQPGAVRA 312
           +++G + +H+A    A    L C+ LL Q   E+ DI  + + T LH+A H       + 
Sbjct: 302 TKNGLSPIHMA----AQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKV 356

Query: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLA 372
           L+ KGA    +  +G T LH+AC++ H+     LL+        T  S+D   ++  GL 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK--------TGASIDAVTES--GLT 406

Query: 373 CLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDA 432
            LH+A+   + P+++ LL+ GA  +V      +T LH+A       + ++LLQ  A+V+A
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 433 RMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           +  +  TPLH AA  G   +   L +  A+  L      TP
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 62/207 (29%), Positives = 89/207 (42%), Gaps = 20/207 (9%)

Query: 286 VLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARC 345
           +L+       TALH+A    Q   VR LV  GA+   Q + G T L++A Q  HL   + 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 346 LLEGRPEPGRGT-------------------SHSLDLQLQNWQGLACLHIATLQKNQPLM 386
           LLE        T                   +H ++   +    L  LHIA    +    
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189

Query: 387 ELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAG 446
            +LL+N  + DV   T G T LH+A   +   + Q LL  GA V+    NG TPLH+A+ 
Sbjct: 190 AVLLQNDPNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 447 RGLMGISSTLCKAGADSLLRNVEDETP 473
           RG + +   L   GA    +  ++ TP
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTP 275



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 60/196 (30%), Positives = 90/196 (45%), Gaps = 11/196 (5%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH+A   +Q    R+L+  G S   +   G T LH+A Q  H      LL        
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL-------- 655

Query: 356 GTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ 415
             S   +  L N  GL  LH+   + + P+ ++L+++G  +D      G T LH+A    
Sbjct: 656 --SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT-RMGYTPLHVASHYG 712

Query: 416 ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQD 475
              LV+FLLQ  A V+A+   G +PLH AA +G   I + L K GA     + +  TP  
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 476 LTEESLVLLPFDDLKI 491
           + +    +   D LK+
Sbjct: 773 IAKRLGYISVTDVLKV 788



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 58/184 (31%), Positives = 81/184 (44%), Gaps = 11/184 (5%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH+A        V AL+ K AS+A   + G T LHVA +   +  A  LLE    P  
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564

Query: 356 GTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ 415
              +          GL  LH+A    N  +++LLL  G         +G T LH+A +  
Sbjct: 565 AGKN----------GLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIAAKQN 613

Query: 416 ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQD 475
           +  + + LLQ G   +A  + G TPLHLAA  G   + + L    A+  L N    TP  
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673

Query: 476 LTEE 479
           L  +
Sbjct: 674 LVAQ 677



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 62/223 (27%), Positives = 105/223 (47%), Gaps = 13/223 (5%)

Query: 251 ALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAV 310
           ++ +  ++G T +H+A       V++  L L     ++ +     T LH A         
Sbjct: 231 SVNFTPQNGITPLHIA--SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 311 RALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQG 370
             L+  GA    + ++G + +H+A Q  HL C R LL+   E         D+ L +   
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-------DITLDH--- 338

Query: 371 LACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQV 430
           L  LH+A    +  + ++LL  GA  +     +G T LH+A +     +++ LL+ GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPN-SRALNGFTPLHIACKKNHVRVMELLLKTGASI 397

Query: 431 DARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           DA   +G TPLH+A+  G + I   L + GA   + NV+ ETP
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 53/185 (28%), Positives = 80/185 (43%), Gaps = 11/185 (5%)

Query: 295 QTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG 354
           QT LH A  +     V+ L+   A+  L    G T LH+A +  H+     LLE      
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 355 RGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVET 414
             T           +G   LH+A       + ELLL   A  +   G +G T LH+AV  
Sbjct: 531 CMTK----------KGFTPLHVAAKYGKVRVAELLLERDAHPNAA-GKNGLTPLHVAVHH 579

Query: 415 QERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQ 474
               +V+ LL  G    +   NG TPLH+AA +  + ++ +L + G  +   +V+  TP 
Sbjct: 580 NNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639

Query: 475 DLTEE 479
            L  +
Sbjct: 640 HLAAQ 644



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 44/156 (28%), Positives = 65/156 (41%), Gaps = 13/156 (8%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVL 315
           S  G T +HLA   E  A ++  L L  Q   ++ N    T LHL            L+ 
Sbjct: 632 SVQGVTPLHLAA-QEGHAEMVALL-LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 316 KGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLH 375
            G       R G T LHVA    ++   + LL+          H  D+  +   G + LH
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ----------HQADVNAKTKLGYSPLH 739

Query: 376 IATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLA 411
            A  Q +  ++ LLL+NGA  + +  + G T L +A
Sbjct: 740 QAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIA 774



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 28/86 (32%), Positives = 40/86 (46%), Gaps = 5/86 (5%)

Query: 390 LRNGADIDV--QEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGR 447
           LRNG DI+   Q G +G   LHLA +     +V  LL     ++     G T LH+AA  
Sbjct: 32  LRNGVDINTCNQNGLNG---LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALA 88

Query: 448 GLMGISSTLCKAGADSLLRNVEDETP 473
           G   +   L   GA+   ++ +  TP
Sbjct: 89  GQDEVVRELVNYGANVNAQSQKGFTP 114


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 66/221 (29%), Positives = 109/221 (49%), Gaps = 19/221 (8%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQ---EVLDIQNNLYQTALHLAVHLDQPGAVRA 312
           +++G + +H+A    A    L C+ LL Q   E+ DI  + + T LH+A H       + 
Sbjct: 302 TKNGLSPIHMA----AQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKV 356

Query: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLA 372
           L+ KGA    +  +G T LH+AC++ H+     LL+        T  S+D   ++  GL 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK--------TGASIDAVTES--GLT 406

Query: 373 CLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDA 432
            LH+A+   + P+++ LL+ GA  +V      +T LH+A       + ++LLQ  A+V+A
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 433 RMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           +  +  TPLH AA  G   +   L +  A+  L      TP
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 62/207 (29%), Positives = 89/207 (42%), Gaps = 20/207 (9%)

Query: 286 VLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARC 345
           +L+       TALH+A    Q   VR LV  GA+   Q + G T L++A Q  HL   + 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 346 LLEGRPEPGRGT-------------------SHSLDLQLQNWQGLACLHIATLQKNQPLM 386
           LLE        T                   +H ++   +    L  LHIA    +    
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189

Query: 387 ELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAG 446
            +LL+N  + DV   T G T LH+A   +   + Q LL  GA V+    NG TPLH+A+ 
Sbjct: 190 AVLLQNDPNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 447 RGLMGISSTLCKAGADSLLRNVEDETP 473
           RG + +   L   GA    +  ++ TP
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTP 275



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 60/196 (30%), Positives = 90/196 (45%), Gaps = 11/196 (5%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH+A   +Q    R+L+  G S   +   G T LH+A Q  H      LL        
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL-------- 655

Query: 356 GTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ 415
             S   +  L N  GL  LH+   + + P+ ++L+++G  +D      G T LH+A    
Sbjct: 656 --SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT-RMGYTPLHVASHYG 712

Query: 416 ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQD 475
              LV+FLLQ  A V+A+   G +PLH AA +G   I + L K GA     + +  TP  
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 476 LTEESLVLLPFDDLKI 491
           + +    +   D LK+
Sbjct: 773 IAKRLGYISVTDVLKV 788



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 58/184 (31%), Positives = 81/184 (44%), Gaps = 11/184 (5%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH+A        V AL+ K AS+A   + G T LHVA +   +  A  LLE    P  
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564

Query: 356 GTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ 415
              +          GL  LH+A    N  +++LLL  G         +G T LH+A +  
Sbjct: 565 AGKN----------GLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIAAKQN 613

Query: 416 ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQD 475
           +  + + LLQ G   +A  + G TPLHLAA  G   + + L    A+  L N    TP  
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673

Query: 476 LTEE 479
           L  +
Sbjct: 674 LVAQ 677



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 62/223 (27%), Positives = 105/223 (47%), Gaps = 13/223 (5%)

Query: 251 ALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAV 310
           ++ +  ++G T +H+A       V++  L L     ++ +     T LH A         
Sbjct: 231 SVNFTPQNGITPLHIA--SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 311 RALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQG 370
             L+  GA    + ++G + +H+A Q  HL C R LL+   E         D+ L +   
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-------DITLDH--- 338

Query: 371 LACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQV 430
           L  LH+A    +  + ++LL  GA  +     +G T LH+A +     +++ LL+ GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPN-SRALNGFTPLHIACKKNHVRVMELLLKTGASI 397

Query: 431 DARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           DA   +G TPLH+A+  G + I   L + GA   + NV+ ETP
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 53/185 (28%), Positives = 80/185 (43%), Gaps = 11/185 (5%)

Query: 295 QTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG 354
           QT LH A  +     V+ L+   A+  L    G T LH+A +  H+     LLE      
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 355 RGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVET 414
             T           +G   LH+A       + ELLL   A  +   G +G T LH+AV  
Sbjct: 531 CMTK----------KGFTPLHVAAKYGKVRVAELLLERDAHPNAA-GKNGLTPLHVAVHH 579

Query: 415 QERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQ 474
               +V+ LL  G    +   NG TPLH+AA +  + ++ +L + G  +   +V+  TP 
Sbjct: 580 NNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639

Query: 475 DLTEE 479
            L  +
Sbjct: 640 HLAAQ 644



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 44/156 (28%), Positives = 65/156 (41%), Gaps = 13/156 (8%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVL 315
           S  G T +HLA   E  A ++  L L  Q   ++ N    T LHL            L+ 
Sbjct: 632 SVQGVTPLHLAA-QEGHAEMVALL-LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 316 KGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLH 375
            G       R G T LHVA    ++   + LL+          H  D+  +   G + LH
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ----------HQADVNAKTKLGYSPLH 739

Query: 376 IATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLA 411
            A  Q +  ++ LLL+NGA  + +  + G T L +A
Sbjct: 740 QAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIA 774



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 28/86 (32%), Positives = 40/86 (46%), Gaps = 5/86 (5%)

Query: 390 LRNGADIDV--QEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGR 447
           LRNG DI+   Q G +G   LHLA +     +V  LL     ++     G T LH+AA  
Sbjct: 32  LRNGVDINTCNQNGLNG---LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALA 88

Query: 448 GLMGISSTLCKAGADSLLRNVEDETP 473
           G   +   L   GA+   ++ +  TP
Sbjct: 89  GQDEVVRELVNYGANVNAQSQKGFTP 114


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 66/221 (29%), Positives = 109/221 (49%), Gaps = 19/221 (8%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQ---EVLDIQNNLYQTALHLAVHLDQPGAVRA 312
           +++G + +H+A    A    L C+ LL Q   E+ DI  + + T LH+A H       + 
Sbjct: 302 TKNGLSPIHMA----AQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKV 356

Query: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLA 372
           L+ KGA    +  +G T LH+AC++ H+     LL+        T  S+D   ++  GL 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK--------TGASIDAVTES--GLT 406

Query: 373 CLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDA 432
            LH+A+   + P+++ LL+ GA  +V      +T LH+A       + ++LLQ  A+V+A
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 433 RMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           +  +  TPLH AA  G   +   L +  A+  L      TP
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 62/207 (29%), Positives = 89/207 (42%), Gaps = 20/207 (9%)

Query: 286 VLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARC 345
           +L+       TALH+A    Q   VR LV  GA+   Q + G T L++A Q  HL   + 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 346 LLEGRPEPGRGT-------------------SHSLDLQLQNWQGLACLHIATLQKNQPLM 386
           LLE        T                   +H ++   +    L  LHIA    +    
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189

Query: 387 ELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAG 446
            +LL+N  + DV   T G T LH+A   +   + Q LL  GA V+    NG TPLH+A+ 
Sbjct: 190 AVLLQNDPNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 447 RGLMGISSTLCKAGADSLLRNVEDETP 473
           RG + +   L   GA    +  ++ TP
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTP 275



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 60/196 (30%), Positives = 90/196 (45%), Gaps = 11/196 (5%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH+A   +Q    R+L+  G S   +   G T LH+A Q  H      LL        
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL-------- 655

Query: 356 GTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ 415
             S   +  L N  GL  LH+   + + P+ ++L+++G  +D      G T LH+A    
Sbjct: 656 --SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT-RMGYTPLHVASHYG 712

Query: 416 ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQD 475
              LV+FLLQ  A V+A+   G +PLH AA +G   I + L K GA     + +  TP  
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 476 LTEESLVLLPFDDLKI 491
           + +    +   D LK+
Sbjct: 773 IAKRLGYISVTDVLKV 788



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 58/184 (31%), Positives = 81/184 (44%), Gaps = 11/184 (5%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH+A        V AL+ K AS+A   + G T LHVA +   +  A  LLE    P  
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564

Query: 356 GTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ 415
              +          GL  LH+A    N  +++LLL  G         +G T LH+A +  
Sbjct: 565 AGKN----------GLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIAAKQN 613

Query: 416 ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQD 475
           +  + + LLQ G   +A  + G TPLHLAA  G   + + L    A+  L N    TP  
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673

Query: 476 LTEE 479
           L  +
Sbjct: 674 LVAQ 677



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 62/223 (27%), Positives = 105/223 (47%), Gaps = 13/223 (5%)

Query: 251 ALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAV 310
           ++ +  ++G T +H+A       V++  L L     ++ +     T LH A         
Sbjct: 231 SVNFTPQNGITPLHIA--SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 311 RALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQG 370
             L+  GA    + ++G + +H+A Q  HL C R LL+   E         D+ L +   
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-------DITLDH--- 338

Query: 371 LACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQV 430
           L  LH+A    +  + ++LL  GA  +     +G T LH+A +     +++ LL+ GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPN-SRALNGFTPLHIACKKNHVRVMELLLKTGASI 397

Query: 431 DARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           DA   +G TPLH+A+  G + I   L + GA   + NV+ ETP
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 53/185 (28%), Positives = 80/185 (43%), Gaps = 11/185 (5%)

Query: 295 QTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG 354
           QT LH A  +     V+ L+   A+  L    G T LH+A +  H+     LLE      
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 355 RGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVET 414
             T           +G   LH+A       + ELLL   A  +   G +G T LH+AV  
Sbjct: 531 CMTK----------KGFTPLHVAAKYGKVRVAELLLERDAHPNAA-GKNGLTPLHVAVHH 579

Query: 415 QERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQ 474
               +V+ LL  G    +   NG TPLH+AA +  + ++ +L + G  +   +V+  TP 
Sbjct: 580 NNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639

Query: 475 DLTEE 479
            L  +
Sbjct: 640 HLAAQ 644



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 44/156 (28%), Positives = 65/156 (41%), Gaps = 13/156 (8%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVL 315
           S  G T +HLA   E  A ++  L L  Q   ++ N    T LHL            L+ 
Sbjct: 632 SVQGVTPLHLAA-QEGHAEMVALL-LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 316 KGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLH 375
            G       R G T LHVA    ++   + LL+          H  D+  +   G + LH
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ----------HQADVNAKTKLGYSPLH 739

Query: 376 IATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLA 411
            A  Q +  ++ LLL+NGA  + +  + G T L +A
Sbjct: 740 QAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIA 774



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 28/86 (32%), Positives = 40/86 (46%), Gaps = 5/86 (5%)

Query: 390 LRNGADIDV--QEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGR 447
           LRNG DI+   Q G +G   LHLA +     +V  LL     ++     G T LH+AA  
Sbjct: 32  LRNGVDINTCNQNGLNG---LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALA 88

Query: 448 GLMGISSTLCKAGADSLLRNVEDETP 473
           G   +   L   GA+   ++ +  TP
Sbjct: 89  GQDEVVRELVNYGANVNAQSQKGFTP 114


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 66/221 (29%), Positives = 109/221 (49%), Gaps = 19/221 (8%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQ---EVLDIQNNLYQTALHLAVHLDQPGAVRA 312
           +++G + +H+A    A    L C+ LL Q   E+ DI  + + T LH+A H       + 
Sbjct: 302 TKNGLSPIHMA----AQGDHLDCVRLLLQYDAEIDDITLD-HLTPLHVAAHCGHHRVAKV 356

Query: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLA 372
           L+ KGA    +  +G T LH+AC++ H+     LL+        T  S+D   ++  GL 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK--------TGASIDAVTES--GLT 406

Query: 373 CLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDA 432
            LH+A+   + P+++ LL+ GA  +V      +T LH+A       + ++LLQ  A+V+A
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSN-VKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 433 RMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           +  +  TPLH AA  G   +   L +  A+  L      TP
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 62/207 (29%), Positives = 89/207 (42%), Gaps = 20/207 (9%)

Query: 286 VLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARC 345
           +L+       TALH+A    Q   VR LV  GA+   Q + G T L++A Q  HL   + 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 346 LLEGRPEPGRGT-------------------SHSLDLQLQNWQGLACLHIATLQKNQPLM 386
           LLE        T                   +H ++   +    L  LHIA    +    
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189

Query: 387 ELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAG 446
            +LL+N  + DV   T G T LH+A   +   + Q LL  GA V+    NG TPLH+A+ 
Sbjct: 190 AVLLQNDPNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 447 RGLMGISSTLCKAGADSLLRNVEDETP 473
           RG + +   L   GA    +  ++ TP
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTP 275



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 60/196 (30%), Positives = 90/196 (45%), Gaps = 11/196 (5%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH+A   +Q    R+L+  G S   +   G T LH+A Q  H      LL        
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL-------- 655

Query: 356 GTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ 415
             S   +  L N  GL  LH+   + + P+ ++L+++G  +D      G T LH+A    
Sbjct: 656 --SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT-RMGYTPLHVASHYG 712

Query: 416 ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQD 475
              LV+FLLQ  A V+A+   G +PLH AA +G   I + L K GA     + +  TP  
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772

Query: 476 LTEESLVLLPFDDLKI 491
           + +    +   D LK+
Sbjct: 773 IAKRLGYISVTDVLKV 788



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 58/184 (31%), Positives = 81/184 (44%), Gaps = 11/184 (5%)

Query: 296 TALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGR 355
           T LH+A        V AL+ K AS+A   + G T LHVA +   +  A  LLE    P  
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA 564

Query: 356 GTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ 415
              +          GL  LH+A    N  +++LLL  G         +G T LH+A +  
Sbjct: 565 AGKN----------GLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIAAKQN 613

Query: 416 ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQD 475
           +  + + LLQ G   +A  + G TPLHLAA  G   + + L    A+  L N    TP  
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673

Query: 476 LTEE 479
           L  +
Sbjct: 674 LVAQ 677



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 62/223 (27%), Positives = 105/223 (47%), Gaps = 13/223 (5%)

Query: 251 ALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAV 310
           ++ +  ++G T +H+A       V++  L L     ++ +     T LH A         
Sbjct: 231 SVNFTPQNGITPLHIA--SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 311 RALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQG 370
             L+  GA    + ++G + +H+A Q  HL C R LL+   E         D+ L +   
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-------DITLDH--- 338

Query: 371 LACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQV 430
           L  LH+A    +  + ++LL  GA  +     +G T LH+A +     +++ LL+ GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPN-SRALNGFTPLHIACKKNHVRVMELLLKTGASI 397

Query: 431 DARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           DA   +G TPLH+A+  G + I   L + GA   + NV+ ETP
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP 440



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 53/185 (28%), Positives = 80/185 (43%), Gaps = 11/185 (5%)

Query: 295 QTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG 354
           QT LH A  +     V+ L+   A+  L    G T LH+A +  H+     LLE      
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 355 RGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVET 414
             T           +G   LH+A       + ELLL   A  +   G +G T LH+AV  
Sbjct: 531 CMTK----------KGFTPLHVAAKYGKVRVAELLLERDAHPNAA-GKNGLTPLHVAVHH 579

Query: 415 QERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQ 474
               +V+ LL  G    +   NG TPLH+AA +  + ++ +L + G  +   +V+  TP 
Sbjct: 580 NNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639

Query: 475 DLTEE 479
            L  +
Sbjct: 640 HLAAQ 644



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 44/156 (28%), Positives = 65/156 (41%), Gaps = 13/156 (8%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVL 315
           S  G T +HLA   E  A ++  L L  Q   ++ N    T LHL            L+ 
Sbjct: 632 SVQGVTPLHLAA-QEGHAEMVALL-LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 316 KGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLH 375
            G       R G T LHVA    ++   + LL+          H  D+  +   G + LH
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ----------HQADVNAKTKLGYSPLH 739

Query: 376 IATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLA 411
            A  Q +  ++ LLL+NGA  + +  + G T L +A
Sbjct: 740 QAAQQGHTDIVTLLLKNGASPN-EVSSDGTTPLAIA 774



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 28/86 (32%), Positives = 40/86 (46%), Gaps = 5/86 (5%)

Query: 390 LRNGADIDV--QEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGR 447
           LRNG DI+   Q G +G   LHLA +     +V  LL     ++     G T LH+AA  
Sbjct: 32  LRNGVDINTCNQNGLNG---LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALA 88

Query: 448 GLMGISSTLCKAGADSLLRNVEDETP 473
           G   +   L   GA+   ++ +  TP
Sbjct: 89  GQDEVVRELVNYGANVNAQSQKGFTP 114


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 55/182 (30%), Positives = 90/182 (49%), Gaps = 12/182 (6%)

Query: 295 QTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG 354
           ++ LH+A +      +  L+ KGA+   QD  G T LH+A +     C   LLE      
Sbjct: 66  RSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLE------ 119

Query: 355 RGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVET 414
               +S D+ + N +GL  +H   +     L+  L+++ +D+DV++   G+TALH+A + 
Sbjct: 120 ----YSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAM-GQTALHVACQN 174

Query: 415 QERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQ 474
             +  VQ LL +GA ++   ++G TPL+ A   G    +  L   GA   L +    TP 
Sbjct: 175 GHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGA-KYLPDKNGVTPL 233

Query: 475 DL 476
           DL
Sbjct: 234 DL 235



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 29/92 (31%), Positives = 47/92 (51%)

Query: 381 KNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTP 440
           +++ + ELL  +  D++   G   ++ LH+A        +  LL+ GA  + + ++GCTP
Sbjct: 42  QHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTP 101

Query: 441 LHLAAGRGLMGISSTLCKAGADSLLRNVEDET 472
           LHLAA  G     S L +  AD  + N E  T
Sbjct: 102 LHLAARNGQKKCMSKLLEYSADVNICNNEGLT 133



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 44/184 (23%), Positives = 78/184 (42%), Gaps = 18/184 (9%)

Query: 287 LDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCL 346
           +D+++ + QTALH+A        V+ L+  GA     +  G T L+ AC       A+ L
Sbjct: 157 VDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQIL 216

Query: 347 L--EGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSG 404
           L    +  P +     LDL +Q   G  C     +Q +  L + +++   + D++E    
Sbjct: 217 LLRGAKYLPDKNGVTPLDLCVQGGYGETC--EVLIQYHPRLFQTIIQMTQNEDLRENMLR 274

Query: 405 KTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSL 464
           +   HL+ +++ + L             ++L     +    G  L+ +SS    A   SL
Sbjct: 275 QVLEHLSQQSESQYL-------------KILTSLAEVATTNGHKLLSLSSNY-DAQMKSL 320

Query: 465 LRNV 468
           LR V
Sbjct: 321 LRIV 324


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 65/192 (33%), Positives = 90/192 (46%), Gaps = 16/192 (8%)

Query: 298 LHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGT 357
           LH A    Q   V+ L+  GA     +  G+TALH+AC     A A  L+          
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNA-------- 261

Query: 358 SHSLDLQLQNWQGLACLHIATLQKNQPL-MELLLRNGADIDVQEGTSGKTALHLAVETQE 416
               ++   N +G   LH+A +  N  L +ELL+ NGAD++ Q    GK+ LH+A     
Sbjct: 262 --GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQS-KEGKSPLHMAAIHGR 318

Query: 417 RGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDL 476
               Q L+Q G+++D     G TPLH+AA  G   + STL   GAD+  R + D  P  L
Sbjct: 319 FTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHL 378

Query: 477 TEESLVLLPFDD 488
                VL  F D
Sbjct: 379 A----VLFGFSD 386



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 68/249 (27%), Positives = 111/249 (44%), Gaps = 17/249 (6%)

Query: 231 DPAPRLPL---PHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVL---LCCLALLPQ 284
           D   R PL    +VG +   QL  ++  + +    + L  +H A A     +  L L   
Sbjct: 38  DQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHS 97

Query: 285 EVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACAR 344
             ++ ++ L+QT LH+A          AL    +S  + DR G +ALH A    HL    
Sbjct: 98  ADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVN 157

Query: 345 CLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSG 404
            LL       +G S    L + + +    LH A    +  +++LL+  GAD+  ++   G
Sbjct: 158 LLLN------KGAS----LNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKD-RKG 206

Query: 405 KTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSL 464
              LH A  + +  +V++LL+ GA++D     G T LH+A   G   ++  L  AGA+  
Sbjct: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266

Query: 465 LRNVEDETP 473
             N +  TP
Sbjct: 267 QPNDKGFTP 275



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 56/202 (27%), Positives = 83/202 (41%), Gaps = 11/202 (5%)

Query: 252 LTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVR 311
           + Y S++G + +H+A IH         + +     +D  +    T LH+A        + 
Sbjct: 299 VNYQSKEGKSPLHMAAIHGR--FTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIS 356

Query: 312 ALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHS--------LDL 363
            L+  GA  A +  H    LH+A       C R LL         +S S         D+
Sbjct: 357 TLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDI 416

Query: 364 QLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFL 423
              +  G  CLH A    N   + LLL +GAD+  ++   G+T LH A           L
Sbjct: 417 NTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD-KFGRTPLHYAAANGSYQCAVTL 475

Query: 424 LQAGAQVDARMLNGCTPLHLAA 445
           + AGA V+     GC+PLH AA
Sbjct: 476 VTAGAGVNEADCKGCSPLHYAA 497



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 57/217 (26%), Positives = 89/217 (41%), Gaps = 11/217 (5%)

Query: 259 GDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGA 318
           G T VH A  +     L   L +    + D+++ +  + LHLA +     A++ L     
Sbjct: 550 GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLV 609

Query: 319 SRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIAT 378
           +  ++D  G TAL +A +R    C   L         G S  +  + + W  L   H A 
Sbjct: 610 NLDVRDHKGRTALFLATERGSTECVEVLT------AHGASALIKERKRKWTPL---HAAA 660

Query: 379 LQKNQPLMELLLRNGADIDVQE--GTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLN 436
              +   + LL+ +G   D+ +     G+T L LA+       V  LL+ G+  DA  L 
Sbjct: 661 ASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLR 720

Query: 437 GCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
           G T LH  A  G     + L    A  L R+ +  TP
Sbjct: 721 GRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTP 757



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 14/216 (6%)

Query: 256 SEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDI--QNNLYQTALHLAVHLDQPGAVRAL 313
           ++ G T +H+A +    A+   CL LL     D+  Q+   ++ LH+A    +    + L
Sbjct: 269 NDKGFTPLHVAAVSTNGAL---CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQIL 325

Query: 314 VLKGASRALQDRHGDTALHVACQRQH-LACARCLLEGRPEPGRGTSHSLDLQLQNWQGLA 372
           +  G+     D+ G+T LHVA +  H L  +  +  G     RG      L L    G +
Sbjct: 326 IQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFS 385

Query: 373 CLHIATLQKNQPLM-------ELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQ 425
                 L   Q          E +L  G DI+  +   G+T LH A        +  LL 
Sbjct: 386 DCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNL-GRTCLHAAASGGNVECLNLLLS 444

Query: 426 AGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGA 461
           +GA +  R   G TPLH AA  G    + TL  AGA
Sbjct: 445 SGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 61/222 (27%), Positives = 96/222 (43%), Gaps = 18/222 (8%)

Query: 247 QQLEALTYIS----EDGDTLVHLAVIHEAPAVLLC-CLALLPQEV--LDIQNNLYQTALH 299
           Q LE L  +S    ED ++ + ++ +H A     C  L  L + +  LD++++  +TAL 
Sbjct: 564 QNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALF 623

Query: 300 LAVHLDQPGAVRALVLKGASRALQDRHGD-TALHVACQRQHLACARCLLEGRPEPGRGTS 358
           LA        V  L   GAS  +++R    T LH A    H      L++        + 
Sbjct: 624 LATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLID--------SG 675

Query: 359 HSLDL-QLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQER 417
              D+  + +  G   L +A +  +   + LLL  G+  D  +   G+TALH    T   
Sbjct: 676 ERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAAD-LRGRTALHRGAVTGCE 734

Query: 418 GLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKA 459
             +  LL   A V  R   G TP+HLA+  G   +  TL +A
Sbjct: 735 DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQA 776



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 47/182 (25%), Positives = 80/182 (43%), Gaps = 11/182 (6%)

Query: 281 LLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHL 340
           L  +E +++ +   +T LH A ++     ++ L++ GA+   +D    T LH A   ++ 
Sbjct: 28  LSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNE 87

Query: 341 ACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQE 400
                LL          +HS D+  ++      LH+A   +     E L    + ++V +
Sbjct: 88  KVLGLLL----------AHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD 137

Query: 401 GTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAG 460
             SG++ALH AV +     V  LL  GA ++        PLH AA  G + +   L   G
Sbjct: 138 -RSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARG 196

Query: 461 AD 462
           AD
Sbjct: 197 AD 198



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 56/221 (25%), Positives = 82/221 (37%), Gaps = 40/221 (18%)

Query: 253 TYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRA 312
           +Y+  +  T +H AVI+   +     L  L  ++++ ++   +T LH A   D    +R 
Sbjct: 817 SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRM 876

Query: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLA 372
           L+   A     D  G TAL  A +    A    LL                    ++G A
Sbjct: 877 LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL--------------------YRGKA 916

Query: 373 CLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDA 432
            L +    KN  L  L    G +         K AL +  ETQ+ GL+     A      
Sbjct: 917 DLTVLDENKNTAL-HLACSKGHE---------KCALMILAETQDLGLINATNSALQM--- 963

Query: 433 RMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
                  PLH+AA  GL  +   L   GA  L  + E  TP
Sbjct: 964 -------PLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 43/159 (27%), Positives = 69/159 (43%), Gaps = 10/159 (6%)

Query: 313 LVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLA 372
           L+  GA  +L+DR G TA+H A    +      LLE         S +    +++   ++
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLE--------MSFNCLEDVESTIPVS 587

Query: 373 CLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQ-VD 431
            LH+A    +   ++ L     ++DV++   G+TAL LA E      V+ L   GA  + 
Sbjct: 588 PLHLAAYNGHCEALKTLAETLVNLDVRD-HKGRTALFLATERGSTECVEVLTAHGASALI 646

Query: 432 ARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVED 470
                  TPLH AA  G       L  +G  + + +V D
Sbjct: 647 KERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD 685



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 48/178 (26%), Positives = 64/178 (35%), Gaps = 17/178 (9%)

Query: 277 CCLALLPQEVLDIQNNLY-QTALHLAVHLDQPGAVRALVLKGASR----ALQDRHGDTAL 331
           C  ALL  +   +  +   +T +HLA        +R L+    S     A  D  G + +
Sbjct: 736 CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPM 795

Query: 332 HVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLR 391
           H A    H  C   LLE  P                      LH A +       E+LL 
Sbjct: 796 HWASYTGHEDCLELLLEHSP-----------FSYLEGNPFTPLHCAVINNQDSTTEMLLG 844

Query: 392 N-GADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRG 448
             GA I       G+T LH A        ++ LLQ  A+V+A    G T L  AA  G
Sbjct: 845 ALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENG 902



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 40/162 (24%), Positives = 61/162 (37%), Gaps = 16/162 (9%)

Query: 287 LDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCL 346
           ++  +NL +T LH A        +  L+  GA    +D+ G T LH A       CA  L
Sbjct: 416 INTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTL 475

Query: 347 LEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKT 406
           +      G G + +      + +G + LH A         E    +  D +  E      
Sbjct: 476 VTA----GAGVNEA------DCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDE------ 519

Query: 407 ALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRG 448
            L  +   +    ++FLL  GA    R   G T +H AA  G
Sbjct: 520 PLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYG 561



 Score = 32.7 bits (73), Expect = 0.79
 Identities = 30/103 (29%), Positives = 46/103 (44%), Gaps = 12/103 (11%)

Query: 252  LTYISEDGDTLVHLAVI--HEAPAVLLCCLALLPQE----VLDIQNNLYQTALHLAVHLD 305
            LT + E+ +T +HLA    HE      C L +L +     +++  N+  Q  LH+A    
Sbjct: 918  LTVLDENKNTALHLACSKGHEK-----CALMILAETQDLGLINATNSALQMPLHIAARNG 972

Query: 306  QPGAVRALVLKGASRALQDRHGDT-ALHVACQRQHLACARCLL 347
                V+AL+  GA+    D  G T AL  A  +    C   +L
Sbjct: 973  LASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 62/220 (28%), Positives = 102/220 (46%), Gaps = 15/220 (6%)

Query: 255 ISEDGDTLVHLAVIH-EAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRAL 313
           +++ G T +HLA      P V +   A      LD+Q++  QTALH A  +     + AL
Sbjct: 38  VTKHGRTPLHLAANKGHLPVVQILLKAGCD---LDVQDDGDQTALHRATVVGNTEIIAAL 94

Query: 314 VLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLAC 373
           + +G +   QD+ G+TALH A        A+ L++             ++  +N  G   
Sbjct: 95  IHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKA----------GANVLAKNKAGNTA 144

Query: 374 LHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDAR 433
           LH+A    +     +LL  G+  D++   +G T LH+A       +++ LL A   V  +
Sbjct: 145 LHLACQNSHSQSTRVLLLAGSRADLKNN-AGDTCLHVAARYNHLSIIRLLLTAFCSVHEK 203

Query: 434 MLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP 473
              G T LH+AA      ++  L +AGAD+ + N   +TP
Sbjct: 204 NQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTP 243



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 60/201 (29%), Positives = 88/201 (43%), Gaps = 24/201 (11%)

Query: 259 GDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGA 318
           G+T +  A+IHE  A             LD Q+    TALH A       + + LV  GA
Sbjct: 86  GNTEIIAALIHEGCA-------------LDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132

Query: 319 SRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIAT 378
           +   +++ G+TALH+ACQ  H    R LL                 L+N  G  CLH+A 
Sbjct: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA----------DLKNNAGDTCLHVAA 182

Query: 379 LQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGC 438
              +  ++ LLL     +  ++  +G TALH+A     + + + LL+AGA        G 
Sbjct: 183 RYNHLSIIRLLLTAFCSVH-EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQ 241

Query: 439 TPLHLAAGRGLMGISSTLCKA 459
           TPL  A       ++  L KA
Sbjct: 242 TPLETARYHNNPEVALLLTKA 262



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 55/175 (31%), Positives = 80/175 (45%), Gaps = 12/175 (6%)

Query: 298 LHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGT 357
           L +A +  Q   V  L+ KGA R    +HG T LH+A  + HL   + LL+         
Sbjct: 14  LLVAAYKGQTENVVQLINKGA-RVAVTKHGRTPLHLAANKGHLPVVQILLKA-------- 64

Query: 358 SHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQER 417
               DL +Q+      LH AT+  N  ++  L+  G  +D Q+   G TALH A      
Sbjct: 65  --GCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQD-KDGNTALHEASWHGFS 121

Query: 418 GLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDET 472
              + L++AGA V A+   G T LHLA        +  L  AG+ + L+N   +T
Sbjct: 122 QSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDT 176



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 50/164 (30%), Positives = 77/164 (46%), Gaps = 19/164 (11%)

Query: 251 ALTYISEDGDTLVHLAVIH---EAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQP 307
           AL    +DG+T +H A  H   ++  +L+   A     VL  +N    TALHLA      
Sbjct: 100 ALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA----NVL-AKNKAGNTALHLACQNSHS 154

Query: 308 GAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQN 367
            + R L+L G+   L++  GDT LHVA +  HL+  R LL          +    +  +N
Sbjct: 155 QSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL----------TAFCSVHEKN 204

Query: 368 WQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLA 411
             G   LH+A    ++ + ++LL  GAD  +    +G+T L  A
Sbjct: 205 QAGDTALHVAAALNHKKVAKILLEAGADTTI-VNNAGQTPLETA 247


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 52/166 (31%), Positives = 84/166 (50%), Gaps = 13/166 (7%)

Query: 310 VRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQ 369
           +R L+LKG   +   R+G TALH+A  + +      LL              D+Q   + 
Sbjct: 84  IRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS----------GADIQQVGYG 133

Query: 370 GLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQ 429
           GL  LHIAT+  +    ++LL++GA++++Q+     T LH+A       + + LL+ GA 
Sbjct: 134 GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFF-TPLHIAAYYGHEQVTRLLLKFGAD 192

Query: 430 VDARMLNGCTPLHLAAGRGLMGISSTLCKAG--ADSLLRNVEDETP 473
           V+     G  PLHLA+ +G + I+  L + G  AD   ++ ED  P
Sbjct: 193 VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 74/260 (28%), Positives = 113/260 (43%), Gaps = 51/260 (19%)

Query: 252 LTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVR 311
           L Y +E+G +L+HL  I       +  L L       +  N + TALHLAV+ D    + 
Sbjct: 60  LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGF-TALHLAVYKDNAELIT 118

Query: 312 ALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGL 371
           +L+  GA        G TALH+A    HL  A  LL+          H  ++ +Q+    
Sbjct: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ----------HGANVNIQDAVFF 168

Query: 372 ACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLA-------------------- 411
             LHIA    ++ +  LLL+ GAD++V  G  G   LHLA                    
Sbjct: 169 TPLHIAAYYGHEQVTRLLLKFGADVNV-SGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 227

Query: 412 VETQE---------------RGLVQFLLQAGAQVDARMLN--GCTPLHLAAGRGLMGISS 454
           V  Q+                 +V++LLQ+  +V   ++N  G TPLHLA   G   ++ 
Sbjct: 228 VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAK 287

Query: 455 TLCK-AGADSLLR-NVEDET 472
            + + +G +SL + N+  ET
Sbjct: 288 EIIQISGTESLTKENIFSET 307



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 38/144 (26%), Positives = 68/144 (47%), Gaps = 11/144 (7%)

Query: 361 LDLQLQNWQGLACLHIATL--QKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERG 418
           ++L  +   GL+ LH+  +   K   +  L+L+      +    +G TALHLAV      
Sbjct: 58  VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR--NGFTALHLAVYKDNAE 115

Query: 419 LVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLT- 477
           L+  LL +GA +      G T LH+A   G +  +  L + GA+  +++    TP  +  
Sbjct: 116 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 175

Query: 478 -----EESLVLLPFD-DLKISGKL 495
                + + +LL F  D+ +SG++
Sbjct: 176 YYGHEQVTRLLLKFGADVNVSGEV 199



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 35/116 (30%), Positives = 49/116 (42%), Gaps = 12/116 (10%)

Query: 326 HGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIA-TLQKNQP 384
           +GDT LH+AC       A+ +++         S +  L  +N       H A T  K+  
Sbjct: 269 YGDTPLHLACYNGKFEVAKEIIQ--------ISGTESLTKENIFSETAFHSACTYGKSID 320

Query: 385 LMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTP 440
           L++ LL         +G  G T LH A       LVQFLL  GA ++   L  C P
Sbjct: 321 LVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN---LVACDP 373



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 27/92 (29%), Positives = 40/92 (43%), Gaps = 2/92 (2%)

Query: 259 GDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQP-GAVRALVLKG 317
           GDT +HLA  +    V    + +   E L  +N   +TA H A    +    V+ L+ + 
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 329

Query: 318 ASRAL-QDRHGDTALHVACQRQHLACARCLLE 348
                 Q R G T LH AC   H+   + LL+
Sbjct: 330 VININHQGRDGHTGLHSACYHGHIRLVQFLLD 361


>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 52/166 (31%), Positives = 84/166 (50%), Gaps = 13/166 (7%)

Query: 310 VRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQ 369
           +R L+LKG   +   R+G TALH+A  + +      LL              D+Q   + 
Sbjct: 185 IRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS----------GADIQQVGYG 234

Query: 370 GLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQ 429
           GL  LHIAT+  +    ++LL++GA++++Q+     T LH+A       + + LL+ GA 
Sbjct: 235 GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFF-TPLHIAAYYGHEQVTRLLLKFGAD 293

Query: 430 VDARMLNGCTPLHLAAGRGLMGISSTLCKAG--ADSLLRNVEDETP 473
           V+     G  PLHLA+ +G + I+  L + G  AD   ++ ED  P
Sbjct: 294 VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 74/260 (28%), Positives = 113/260 (43%), Gaps = 51/260 (19%)

Query: 252 LTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVR 311
           L Y +E+G +L+HL  I       +  L L       +  N + TALHLAV+ D    + 
Sbjct: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGF-TALHLAVYKDNAELIT 219

Query: 312 ALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGL 371
           +L+  GA        G TALH+A    HL  A  LL+          H  ++ +Q+    
Sbjct: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ----------HGANVNIQDAVFF 269

Query: 372 ACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLA-------------------- 411
             LHIA    ++ +  LLL+ GAD++V  G  G   LHLA                    
Sbjct: 270 TPLHIAAYYGHEQVTRLLLKFGADVNV-SGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 328

Query: 412 VETQE---------------RGLVQFLLQAGAQVDARMLN--GCTPLHLAAGRGLMGISS 454
           V  Q+                 +V++LLQ+  +V   ++N  G TPLHLA   G   ++ 
Sbjct: 329 VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAK 388

Query: 455 TLCK-AGADSLLR-NVEDET 472
            + + +G +SL + N+  ET
Sbjct: 389 EIIQISGTESLTKENIFSET 408



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 38/144 (26%), Positives = 68/144 (47%), Gaps = 11/144 (7%)

Query: 361 LDLQLQNWQGLACLHIATL--QKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERG 418
           ++L  +   GL+ LH+  +   K   +  L+L+      +    +G TALHLAV      
Sbjct: 159 VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTR--NGFTALHLAVYKDNAE 216

Query: 419 LVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLT- 477
           L+  LL +GA +      G T LH+A   G +  +  L + GA+  +++    TP  +  
Sbjct: 217 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 276

Query: 478 -----EESLVLLPFD-DLKISGKL 495
                + + +LL F  D+ +SG++
Sbjct: 277 YYGHEQVTRLLLKFGADVNVSGEV 300



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 35/116 (30%), Positives = 49/116 (42%), Gaps = 12/116 (10%)

Query: 326 HGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIA-TLQKNQP 384
           +GDT LH+AC       A+ +++         S +  L  +N       H A T  K+  
Sbjct: 370 YGDTPLHLACYNGKFEVAKEIIQ--------ISGTESLTKENIFSETAFHSACTYGKSID 421

Query: 385 LMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTP 440
           L++ LL         +G  G T LH A       LVQFLL  GA ++   L  C P
Sbjct: 422 LVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN---LVACDP 474



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 27/92 (29%), Positives = 40/92 (43%), Gaps = 2/92 (2%)

Query: 259 GDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQP-GAVRALVLKG 317
           GDT +HLA  +    V    + +   E L  +N   +TA H A    +    V+ L+ + 
Sbjct: 371 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 430

Query: 318 ASRAL-QDRHGDTALHVACQRQHLACARCLLE 348
                 Q R G T LH AC   H+   + LL+
Sbjct: 431 VININHQGRDGHTGLHSACYHGHIRLVQFLLD 462


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.133    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,504,905
Number of Sequences: 37866
Number of extensions: 1467544
Number of successful extensions: 12754
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 390
Number of HSP's successfully gapped in prelim test: 907
Number of HSP's that attempted gapping in prelim test: 7429
Number of HSP's gapped (non-prelim): 4057
length of query: 500
length of database: 18,247,518
effective HSP length: 106
effective length of query: 394
effective length of database: 14,233,722
effective search space: 5608086468
effective search space used: 5608086468
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.