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Search of human proteins with 71061468
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71061468 centromere protein E [Homo sapiens]
(2701 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71061468 centromere protein E [Homo sapiens] 5203 0.0
gi|9910266 kinesin family member 15 [Homo sapiens] 347 7e-95
gi|116686122 kinesin family member 4 [Homo sapiens] 328 4e-89
gi|150010604 kinesin family member 4B [Homo sapiens] 320 9e-87
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 311 4e-84
gi|4758648 kinesin family member 5B [Homo sapiens] 294 9e-79
gi|4758650 kinesin family member 5C [Homo sapiens] 293 1e-78
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens] 292 3e-78
gi|4758646 kinesin family member 3B [Homo sapiens] 288 4e-77
gi|46852174 kinesin family member 3A [Homo sapiens] 288 5e-77
gi|30794488 kinesin family member 27 [Homo sapiens] 288 5e-77
gi|45446749 kinesin family member 5A [Homo sapiens] 281 8e-75
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 279 2e-74
gi|55770834 centromere protein F [Homo sapiens] 270 1e-71
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 268 4e-71
gi|170784809 kinesin family member 17 isoform b [Homo sapiens] 267 9e-71
gi|170784807 kinesin family member 17 isoform a [Homo sapiens] 267 9e-71
gi|21735548 centrosomal protein 2 [Homo sapiens] 265 5e-70
gi|13699824 kinesin family member 11 [Homo sapiens] 257 1e-67
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 250 2e-65
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 249 2e-65
gi|46852172 kinesin family member 13B [Homo sapiens] 246 3e-64
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 244 8e-64
gi|38569484 kinesin family member 21A [Homo sapiens] 244 1e-63
gi|41352705 kinesin family member 3C [Homo sapiens] 243 1e-63
gi|157738629 kinesin family member 13A isoform d [Homo sapiens] 242 4e-63
gi|157738627 kinesin family member 13A isoform c [Homo sapiens] 242 4e-63
gi|157738625 kinesin family member 13A isoform b [Homo sapiens] 242 4e-63
gi|157738621 kinesin family member 13A isoform a [Homo sapiens] 242 4e-63
gi|7661878 kinesin family member 14 [Homo sapiens] 237 1e-61
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 5203 bits (13496), Expect = 0.0
Identities = 2701/2701 (100%), Positives = 2701/2701 (100%)
Query: 1 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK 60
MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
Sbjct: 1 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK 60
Query: 61 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF 120
NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
Sbjct: 61 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF 120
Query: 121 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK 180
PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
Sbjct: 121 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK 180
Query: 181 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE 240
WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
Sbjct: 181 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE 240
Query: 241 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA 300
RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
Sbjct: 241 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA 300
Query: 301 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE 360
KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
Sbjct: 301 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE 360
Query: 361 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR 420
EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
Sbjct: 361 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR 420
Query: 421 VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS 480
VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
Sbjct: 421 VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS 480
Query: 481 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL 540
EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
Sbjct: 481 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL 540
Query: 541 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS 600
ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS
Sbjct: 541 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS 600
Query: 601 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT 660
QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
Sbjct: 601 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT 660
Query: 661 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG 720
TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
Sbjct: 661 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG 720
Query: 721 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL 780
KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
Sbjct: 721 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL 780
Query: 781 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN 840
FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
Sbjct: 781 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN 840
Query: 841 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
Sbjct: 841 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
Query: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
Query: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
Query: 1021 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080
LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
Sbjct: 1021 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080
Query: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ 1140
IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ 1140
Query: 1141 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK 1200
QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
Sbjct: 1141 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK 1200
Query: 1201 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
Sbjct: 1201 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
Query: 1261 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS 1320
KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
Sbjct: 1261 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS 1320
Query: 1321 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ 1380
TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
Sbjct: 1321 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ 1380
Query: 1381 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV 1440
ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
Sbjct: 1381 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV 1440
Query: 1441 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL 1500
AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
Sbjct: 1441 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL 1500
Query: 1501 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK 1560
SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
Sbjct: 1501 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK 1560
Query: 1561 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM 1620
DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
Sbjct: 1561 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM 1620
Query: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680
KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
Sbjct: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680
Query: 1681 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL 1740
MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
Sbjct: 1681 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL 1740
Query: 1741 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK 1800
RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
Sbjct: 1741 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK 1800
Query: 1801 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS 1860
TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
Sbjct: 1801 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS 1860
Query: 1861 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL 1920
LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
Sbjct: 1861 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL 1920
Query: 1921 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL 1980
EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL
Sbjct: 1921 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL 1980
Query: 1981 QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE 2040
QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE
Sbjct: 1981 QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE 2040
Query: 2041 RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI 2100
RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI
Sbjct: 2041 RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI 2100
Query: 2101 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ 2160
KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ
Sbjct: 2101 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ 2160
Query: 2161 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD 2220
RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD
Sbjct: 2161 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD 2220
Query: 2221 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF 2280
VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF
Sbjct: 2221 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF 2280
Query: 2281 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE 2340
DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE
Sbjct: 2281 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE 2340
Query: 2341 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK 2400
KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK
Sbjct: 2341 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK 2400
Query: 2401 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL 2460
ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL
Sbjct: 2401 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL 2460
Query: 2461 KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD 2520
KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD
Sbjct: 2461 KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD 2520
Query: 2521 PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL 2580
PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL
Sbjct: 2521 PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL 2580
Query: 2581 SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP 2640
SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP
Sbjct: 2581 SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP 2640
Query: 2641 KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT 2700
KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT
Sbjct: 2641 KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT 2700
Query: 2701 Q 2701
Q
Sbjct: 2701 Q 2701
>gi|9910266 kinesin family member 15 [Homo sapiens]
Length = 1388
Score = 347 bits (891), Expect = 7e-95
Identities = 394/1421 (27%), Positives = 651/1421 (45%), Gaps = 230/1421 (16%)
Query: 3 EEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGS---KSFNFDRVFHGNETT 59
E A+ V VR+RP R S + ++ ++ + K+F FD V + T
Sbjct: 23 EGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPEPKTFTFDHVADVDTTQ 82
Query: 60 KNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMG-------SEDHLGVIPRAIHD 112
++V+ +A I++S + GYNGTIFAYGQT SGKT+TMMG S + GVIPR+
Sbjct: 83 ESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEY 142
Query: 113 IF-----QKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADL 167
+F +K K + FL + S++EIYNE I DLL L +RE + + V+V
Sbjct: 143 LFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLL--DSASAGLYLREHIKKGVFVVGA 200
Query: 168 TEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVK 227
E+VV ++ A + ++ G ++R T MN+ SSRSH +F + +ES EK SN +++
Sbjct: 201 VEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEK---SNEIVNIR 257
Query: 228 VSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVG--GFINYRD 285
S LNLVDLAGSER T A G+RLKE NINRSL LGQVI L D G + YRD
Sbjct: 258 TSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRD 317
Query: 286 SKLTRILQNSLGGNAKTRIICTITPVS--FDETLTALQFASTAKYMKNTPYVNE-----V 338
SKLT +L++SLGGNAKT II + P S F ETL+ L FA AK +KN VNE V
Sbjct: 318 SKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNV 377
Query: 339 STDEALLKRYRKEIMDLKK-QLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENL 397
S +A +KR ++++ +L Q S TR + +K + +E L K ++ ++L
Sbjct: 378 SQLQAEVKRLKEQLAELASGQTPPESFLTRDK--KKTNYMEYFQEAMLFFKKSEQEKKSL 435
Query: 398 TRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSI-N 456
+ LTL++E + NKM DQ K HK S
Sbjct: 436 IEKVTQLEDLTLKKEKFIQS-----------NKMIVKFREDQI----IRLEKLHKESRGG 480
Query: 457 LLREIDESVCSESDVFSNTLDTLSE-IEWNPATKLLNQENIESELNSLRADYDNLVLDYE 515
L E + + SE N + TL E IE +P EN +SLR + L L
Sbjct: 481 FLPEEQDRLLSE---LRNEIQTLREQIEHHPRVAKYAMEN-----HSLREENRRLRLLEP 532
Query: 516 QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ--------EMQLIHEISNLKNLVKHAE 567
R ++ + + K + E +E+ K Q E L LK + +
Sbjct: 533 VKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQ 592
Query: 568 VYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTL 627
+ + E EL R+++ +++ + Q L+ ++L LE+ + K+ + +
Sbjct: 593 TELNNSKQEYEEFKELTRKRQLELES-----ELQSLQKANLNLENLLEATKACKRQEVSQ 647
Query: 628 FD---AETVALDAKRESAF-LRSENL-ELKEKMKELATTYKQ----MENDIQLYQSQLEA 678
+ AET+ + A+ L S + +L +M + Y Q ++NDI E
Sbjct: 648 LNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEM 707
Query: 679 KKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNL---ELEGKITDLQKELNKE--- 732
++ + +EL++ +++ L + +D + K+L +LE T +Q+ + E
Sbjct: 708 NEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERID 767
Query: 733 --VEENEALREEVILLSELKS-------LPSEVERLRKEIQDKSEELHII---------- 773
++ E L + +L +L+ L SEV LR + +EL +
Sbjct: 768 WTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTN 827
Query: 774 -TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQ-----------EFQN 821
E +KL +H + ++ L E K + A Q +Y + + QN
Sbjct: 828 QEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQN 887
Query: 822 FK----TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQE 877
FK TL D +++ E ER N+ ++L E K +SS LK L QE Q+
Sbjct: 888 FKKENETLKSDLNNLMELLEAEKERNNK--LSLQFEEDKENSSKEILKV-LEAVRQEKQK 944
Query: 878 KTREVQERLNEMEQLKEQL-----------ENRDS-------------TLQTVEREKTLI 913
+T + ++++ ++++L+E L ++RDS L+T EKT
Sbjct: 945 ETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTET 1004
Query: 914 TEKLQQTLEEVK---------------TLTQEKDDLKQLQESLQ-------IERDQLKSD 951
+ L+Q L+++ + +++ D+ L+E+L+ IERD L D
Sbjct: 1005 IDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCED 1064
Query: 952 I-HDTVNMNIDTQEQ------LRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGET 1004
+ H T +N+ T+ L++A E L + + I L+ K++++ +E +
Sbjct: 1065 LAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQK-------KEEVEQK 1117
Query: 1005 KDEFQQKMVGIDKKQDLEAKNTQT------------LTADVKDNEIIEQQRKIFSLIQEK 1052
K+E+ KM ++ D A++ Q+ + ++ EI + + SL
Sbjct: 1118 KNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLV 1177
Query: 1053 NELQQMLESVIAEKEQLKTDLKENIEMTIENQEELR----LLG--DELKKQQEIVAQE-- 1104
+L + E AE ++K L+E + +E+Q+ + L G D++K+Q+E Q
Sbjct: 1178 TKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHP 1237
Query: 1105 KNHAIKKEGELSRTCDRLAE---VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE 1161
N +K E E S +RLA+ VEE LK K+ L+E Q L N + E M ++ +
Sbjct: 1238 DNQQLKNEQEES-IKERLAKSKIVEEMLKMKA-DLEEVQSALYNKEMECLRMTDEVERTQ 1295
Query: 1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRG 1221
L+++ E+ +L KL E YEE + ++E ++L++ + E L G
Sbjct: 1296 TLESKAFQ----------EKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVG 1345
Query: 1222 ---------YIREIEATGLQTKEE---LKIAHIHLKEHQET 1250
Y+ ++ ++ EE L+ ++ LKE + +
Sbjct: 1346 HQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFLKEKKRS 1386
Score = 142 bits (358), Expect = 4e-33
Identities = 257/1140 (22%), Positives = 482/1140 (42%), Gaps = 191/1140 (16%)
Query: 636 DAKRESAFLRSENLELKEKMKELA----------TTYKQMENDIQLYQSQLEAKKKMQVD 685
D + + L++E LKE++ ELA T K+ N ++ +Q + KK
Sbjct: 372 DTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKS--- 428
Query: 686 LEKELQSAFNEITKLTSLIDGK---VPKDLLCNLELEGKITDLQKELNKEVEENEALREE 742
E+E +S ++T+L L K + + + E +I L+K L+KE E+
Sbjct: 429 -EQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEK-LHKESRGGFLPEEQ 486
Query: 743 VILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK 802
LLSEL++ E++ LR++I+ H K + + + +E+R LLE + + +
Sbjct: 487 DRLLSELRN---EIQTLREQIE------HHPRVAKYAMENHSLREENRRLRLLEPVKRAQ 537
Query: 803 DDLATTQSNYKSTDQEFQNFKTLHMDFE------QKYKMVLEENERMNQEIV-------N 849
+ A T + + E + + + QK + E++ +++ N
Sbjct: 538 EMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNN 597
Query: 850 LSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVERE 909
+E ++F + EL + Q LQ+ ++ L + K Q S L + E
Sbjct: 598 SKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQ---EVSQLNKIHAE 654
Query: 910 KTLI----TEKLQQTLEEVKTLTQEKDDLKQL--QESLQIERDQLKSDIHDTVNMNIDTQ 963
I T+ Q V L+ E L Q S ++ D L + +N
Sbjct: 655 TLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMN------ 708
Query: 964 EQLRNAL-ESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLE 1022
EQ A+ E L+ QE ++ L++K+ EE +NL ++++ +DK LE
Sbjct: 709 EQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQH--------------VDK---LE 751
Query: 1023 AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKT---DLKENIEM 1079
+TQ ++ +E I+ ++ L+ + N L++ L+ + + LK+ DL+ +
Sbjct: 752 HHSTQM--QELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHS 809
Query: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
+ ++L K QE +E N ++ + D L EKL E LQ+
Sbjct: 810 ADKELSSVKLEYSSFKTNQE---KEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDS 866
Query: 1140 QQQLLNVQE-EMSEMQKKIN----EIENLKNELKNKELTLEHMETERLELAQKLNENYEE 1194
L + + E+ ++ + + E E LK++L N +E +E E+ E KL+ +EE
Sbjct: 867 YDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNN---LMELLEAEK-ERNNKLSLQFEE 922
Query: 1195 VKSITKERKVLKELQ-----KSFETER-DHLRGYIREIEATGLQTKEELKIAHIHLKEHQ 1248
K +++LK L+ K ET + + ++++E + L T++ + +
Sbjct: 923 DKE-NSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDK 981
Query: 1249 ET-------IDELRRSVSEKTAQIINT-QDLEKSHTKLQEEIPVLHEEQELLPNVKEVS- 1299
+ I ELR SV EKT I Q+L+ + K + V EE +L +EV
Sbjct: 982 KVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSAL-VDREESRVLIKKQEVDI 1040
Query: 1300 -ETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIK 1358
+ +ET+ L +L+E ++ER L E + E++ LT+
Sbjct: 1041 LDLKETLR-LRILSE-------------DIERDMLCEDLAHATEQLNMLTEASK------ 1080
Query: 1359 EALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR 1418
KH L + +E L K + + + LN K++ E+EQ K +
Sbjct: 1081 -----KHSGLLQSAQEELTKKEALIQELQHKLNQKKE---------EVEQKKNE------ 1120
Query: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEE- 1477
+ ++++ M S A++ +S + + + +AK LET+E
Sbjct: 1121 -------YNFKMRQLEHVMDSAAEDP------------QSPKTPPHFQTHLAKLLETQEQ 1161
Query: 1478 ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNI 1537
E++ E + +L + K EI +++QL + + L+ + Q++ EK
Sbjct: 1162 EIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREM-ENLRLESQQLIEKNWL--- 1217
Query: 1538 KQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR 1597
+Q +++++K+ KE+ Q ++++ E + ++ M+K K +++
Sbjct: 1218 -----LQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEE 1272
Query: 1598 VQEALQIERDQLKENTKEI----VAKMKESQEKEYQFLKMTAVNETQEKMC-EIEHLKEQ 1652
VQ AL + + T E+ + K QEKE K+ + E +E+ E+E L++Q
Sbjct: 1273 VQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQ 1332
Query: 1653 FETQKLNLENIETENIRLT--QILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLR 1710
E + EN +L Q LH+ ++ + + KE L E L+ E LKE R
Sbjct: 1333 VEC-------LAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFLKEKKR 1385
Score = 140 bits (354), Expect = 1e-32
Identities = 244/1160 (21%), Positives = 492/1160 (42%), Gaps = 207/1160 (17%)
Query: 1152 EMQKKINEIENLKNELKN-------KELTLEHMETERLELAQKLNENYEEVKSITKERKV 1204
E +K NEI N++ L N + H E RL+ A +N + + +
Sbjct: 245 ESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVD 304
Query: 1205 LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIH-----LKEHQETIDELRRSVS 1259
+ ++ RD ++ ++ G K + IA++H E T++ +R+
Sbjct: 305 VGNGKQRHVCYRDSKLTFLLR-DSLGGNAKTAI-IANVHPGSRCFGETLSTLNFAQRAKL 362
Query: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEE-----------QELLPNVKEVSETQETMNEL 1308
K ++N +D + + ++LQ E+ L E+ + L K+ + E E
Sbjct: 363 IKNKAVVN-EDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEA 421
Query: 1309 ELLTEQSTTKDSTTLARI-EMERLRLNE-----------KFQESQ--------------- 1341
L ++S + + + ++ ++E L L + KF+E Q
Sbjct: 422 MLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGF 481
Query: 1342 ---EEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQ--EQSLNMKEKD 1396
E+ + L++ R+ ++T++E +E H ++ ++ E + +E++ + E +E D
Sbjct: 482 LPEEQDRLLSELRNEIQTLREQIE-HHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMD 540
Query: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQS 1456
+T ++++E+ + S + + + G S + Q+ + K K L ++Q L +
Sbjct: 541 AQT---IAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNN 597
Query: 1457 ESDQLKENIKEIVAKH-LETEEELK--------------VAHCCLKEQEETINELRVN-- 1499
S Q E KE+ K LE E EL+ C +++ +N++
Sbjct: 598 -SKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETL 656
Query: 1500 -------------------LSEKETEISTIQKQLEAI--NDKLQNKIQ-EIYEKEEQFNI 1537
LS + ++ Q +I ND L + E+ E+ +
Sbjct: 657 KIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAIS 716
Query: 1538 KQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQE--SQEEIQIMIKEKEEM 1595
+++ VQE+++ L+ + + K+ LQ K+ + ++QE S E I K++EE+
Sbjct: 717 EELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERID-WTKQQEEL 775
Query: 1596 --------KRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKM--TAVNETQEKMCE 1645
K++QE Q + D LK ++ + S +KE +K+ ++ QEK E
Sbjct: 776 LSQLNVLEKQLQET-QTKNDFLKSEVHDLRVVL-HSADKELSSVKLEYSSFKTNQEK--E 831
Query: 1646 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQL 1705
L E+ +L L+N+ EN +L + S +D +++E +K E DQL
Sbjct: 832 FNKLSERHMHVQLQLDNLRLENEKL----------LESKACLQDSYDNLQEIMKFEIDQL 881
Query: 1706 KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEIS-NMQKDLEHSNDA 1764
NL+ + +K+ E LK + +L E+ N++S ++D E+S+
Sbjct: 882 SRNLQ-----NFKKENET------LKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKE 930
Query: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824
+ LK+ E +R +E+Q+ K E AK+Q+ +
Sbjct: 931 I----LKVLEAVR------QEKQKETAKC------------------EQQMAKVQKLEES 962
Query: 1825 LKANEHQLITLKKDVNETQKKVSEM----EQLKKQIKDQSLTLSKLEIENLNLAQKLHEN 1880
L A E + +L+K + +K V+++ ++L+ + +++ T+ L+ E ++ K +
Sbjct: 963 LLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSA 1022
Query: 1881 L---EEMKSVMKERD-NLRRVEETLKL-------ERDQLKESLQETKARDLEIQQELKTA 1929
L EE + ++K+++ ++ ++ETL+L ERD L E L ++L
Sbjct: 1023 LVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHAT-------EQLNML 1075
Query: 1930 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRV---- 1985
SK+H + +E++++K I ++Q L++ K+E+++K E K QL V
Sbjct: 1076 TEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSA 1135
Query: 1986 KEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNF---QLTKKLHESLEEIRIVAKERD 2042
ED + L K E Q ++ R L KL+E E
Sbjct: 1136 AEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMK 1195
Query: 2043 ELRRIKESLKMERDQFI-------ATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLRE 2095
E R E+L++E Q I L ++ + + Q P+ + L + Q+ +
Sbjct: 1196 EQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLA 1255
Query: 2096 KCSRIKELLKRYSEMDDHYECLNRLSLD-LEKEIEFQKELSMRVKANLSLPYLQTKHIEK 2154
K ++E+LK +++++ L ++ L E ++ ++ KA L++K +E+
Sbjct: 1256 KSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSK-LEE 1314
Query: 2155 LFTANQRCSMEFHRIMKKLK 2174
++ +R S E + K+++
Sbjct: 1315 MYEERERTSQEMEMLRKQVE 1334
Score = 117 bits (294), Expect = 1e-25
Identities = 234/1156 (20%), Positives = 480/1156 (41%), Gaps = 156/1156 (13%)
Query: 1437 MKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL 1496
+K+ A +D Q LQ+E +LKE + E+ + E L T ++
Sbjct: 363 IKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFL------------TRDKK 410
Query: 1497 RVNLSEKETEISTIQKQLEAINDKLQNKIQEIYE---KEEQF--NIKQISEVQEKVNELK 1551
+ N E E K+ E L K+ ++ + K+E+F + K I + +E ++
Sbjct: 411 KTNYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFRED-QIIR 469
Query: 1552 QFKEHRKAKDSALQSIESKML-ELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK 1610
K H++++ L + ++L EL N +Q +E+I E RV + +
Sbjct: 470 LEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQI-------EHHPRVAKYAMENHSLRE 522
Query: 1611 ENTK-EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIR 1669
EN + ++ +K +QE + Q + + ++ EI +++ + Q+ + E
Sbjct: 523 ENRRLRLLEPVKRAQEMDAQ-----TIAKLEKAFSEISGMEKSDKNQQGFSPKAQKE--- 574
Query: 1670 LTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMH 1729
L N E++++ L ++ L + + +E T R LE + EL+ +
Sbjct: 575 --PCLFANTEKLKA------QLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQ-- 624
Query: 1730 LKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKI-QEELRIAHMHLKEQQE 1788
K + + L + K E+S + K + A+ LKI + +H + +
Sbjct: 625 -KANLNLENLLEATKACKRQEVSQLNK--------IHAETLKIITTPTKAYQLHSRPVPK 675
Query: 1789 TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE 1848
++ S T S + D+ N + Q +A +L T+++ ++ Q K+ E
Sbjct: 676 LSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDE 735
Query: 1849 MEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQL 1908
E +++ + KLE H + + + ER + + +E L + + L
Sbjct: 736 EEHKNLKLQQH---VDKLE----------HHSTQMQELFSSERIDWTKQQEELLSQLNVL 782
Query: 1909 KESLQETKARDLEIQQELKTARM-LSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE 1967
++ LQET+ ++ ++ E+ R+ L KE E S KT Q + K L +
Sbjct: 783 EKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNK-LSERHMH 841
Query: 1968 LQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKL 2027
+Q ++ L+ + +LL K + S+ + E+ +K + + + ++Q+ + +N L L
Sbjct: 842 VQLQLDNLRLENEKLLESKACLQDSYDNLQEI--MKFEIDQLSRNLQNFKKENETLKSDL 899
Query: 2028 HESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQ 2087
+ +E + + ++L E K + I + E + +++Q K E+++ Q
Sbjct: 900 NNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAK--VQ 957
Query: 2088 HLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYL 2147
L ESL ++ L++ + D ++ DL +I+ L
Sbjct: 958 KLEESLLAT-EKVISSLEKSRDSD------KKVVADLMNQIQ----------------EL 994
Query: 2148 QTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKE 2207
+T EK T + + +K + + +EE I K E+D +D E
Sbjct: 995 RTSVCEKTETIDT-----LKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKET--- 1046
Query: 2208 LLIKIQHLQQDCDVPSRELRDLKLNQNMDL-HIEEILKDFSES--EFPSIKTEFQQVLSN 2264
++++ L +D + RD+ DL H E L +E+ + + Q+ L+
Sbjct: 1047 --LRLRILSEDIE------RDMLCE---DLAHATEQLNMLTEASKKHSGLLQSAQEELTK 1095
Query: 2265 RKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATI 2324
++ + Q L+ LN +K + QK+N+ NF ++ +M+ + E + +S
Sbjct: 1096 KEALIQELQHKLN-----QKKEEVEQKKNEY-----NFKMRQLEHVMDSAAE-DPQSPKT 1144
Query: 2325 SKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIR 2384
++ L L E E+ ++ + KTSL + T+ N++ V + E++R
Sbjct: 1145 PPHFQTHLAKLLETQEQEIEDGRASKTSLE-----HLVTKLNEDREVKNAEILRMKEQLR 1199
Query: 2385 ELENSLHEA-----KESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETI 2439
E+EN E+ K + + IK QKE N H N+ L+ +E
Sbjct: 1200 EMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQN----------HPDNQQLKNEQEES 1249
Query: 2440 ---QVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVI 2496
++ + K+ K ++E+++ L ++E ++ E E+ + + +KE +
Sbjct: 1250 IKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQ-EKEQL 1308
Query: 2497 RLLRENL--RRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEK 2554
R E + R + +Q+ ++ + + G + + + LK E++RL +
Sbjct: 1309 RSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAE 1368
Query: 2555 EISKLKQQNEQLIKQK 2570
E KL+ +N L ++K
Sbjct: 1369 ETEKLRAENVFLKEKK 1384
Score = 114 bits (285), Expect = 1e-24
Identities = 234/1149 (20%), Positives = 461/1149 (40%), Gaps = 199/1149 (17%)
Query: 1370 EHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKR 1429
+ ++E LA++ Q+ E L +K + ME F+ ML K
Sbjct: 385 KRLKEQLAELASGQTPPESFLTRDKKKT------NYMEYFQEA----------MLFFKKS 428
Query: 1430 LQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ 1489
QE ++ V + +D + ++ +QS +K +I+ LE + +EQ
Sbjct: 429 EQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQII--RLEKLHKESRGGFLPEEQ 486
Query: 1490 EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEV---QEK 1546
+ ++ELR EI T+++Q+E + ++ +EE ++ + V QE
Sbjct: 487 DRLLSELR-------NEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEM 539
Query: 1547 VNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIER 1606
+ E ++ S ++ + + + Q+ K K ++ ++Q L +
Sbjct: 540 DAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSK 599
Query: 1607 DQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETE 1666
+ +E KE+ K + E E Q L+ +N E + E ++ E +LN + ET
Sbjct: 600 QEYEE-FKELTRKRQLELESELQSLQKANLN--LENLLEATKACKRQEVSQLNKIHAETL 656
Query: 1667 NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKEN--LRETITRDLEKQEELK 1724
I T L R V K ++ S +L + + +N L E + ++ +Q +
Sbjct: 657 KIITTPTKAYQLHS-RPVPKLSPEMGSFG-SLYTQNSSILDNDILNEPVPPEMNEQA-FE 713
Query: 1725 IVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLK 1784
+ L+ QE + L+ + E+ EH N LK+Q+ + H
Sbjct: 714 AISEELRTVQEQMSALQAKLDEE-----------EHKN-------LKLQQHVDKLEHHST 755
Query: 1785 EQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQL-ITLKKDVNETQ 1843
+ QE R +++ ++L + LE + Q K LK+ H L + L E
Sbjct: 756 QMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELS 815
Query: 1844 KKVSEMEQLKKQIKDQSLTLSK------LEIENLNLAQKLHENLEEMKSVMKERDNLRRV 1897
E K + + LS+ L+++NL L +E L E K+ ++ D+ +
Sbjct: 816 SVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLE---NEKLLESKACLQ--DSYDNL 870
Query: 1898 EETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISE-KTIQISD 1956
+E +K E DQL +LQ K + ++ +L L + KE +KL + E K +
Sbjct: 871 QEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKE 930
Query: 1957 IQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSV 2016
I K L+ + E QK+ + +++ ++ +++E + + K I+ +E+
Sbjct: 931 ILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKS-------------- 976
Query: 2017 RMDNFQLTKKLHESLEEIRIVAKERDE-LRRIKESLKMERDQFIATLREMIARDRQNHQV 2075
R + ++ L ++E+R E+ E + +K+ LK ++ + L + R+ +
Sbjct: 977 RDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSAL---VDREESRVLI 1033
Query: 2076 KPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELS 2135
K ++ + D L E+LR L LS D+E+++ +
Sbjct: 1034 KKQEVDILD----LKETLR----------------------LRILSEDIERDMLCEDLAH 1067
Query: 2136 MRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFE 2195
+ N+ L KH L +A + + + I+E QH+ K E
Sbjct: 1068 ATEQLNM-LTEASKKHSGLLQSAQEELTKK--------------EALIQELQHKLNQKKE 1112
Query: 2196 MDFIDEVEKQK-ELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSI 2254
EVE++K E K++ L+ D + + + K + H+ ++L+
Sbjct: 1113 -----EVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLE---------- 1157
Query: 2255 KTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNES 2314
T+ Q++ R T ++ +NE
Sbjct: 1158 -TQEQEIEDGRASKTSL---------------------------------EHLVTKLNED 1183
Query: 2315 TEFEERSATISKEWEQDLKSLK-------EKNEKLFKNYQTLKTSLASGAQVNPTTQDNK 2367
E + KE +++++L+ EKN L +K + Q +P Q K
Sbjct: 1184 REVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLK 1243
Query: 2368 NPHVTSRATQLTTEKIRE----LENSLHEAKESAMHKESKIIKMQKELEVTNDIIAK--- 2420
N S +L KI E ++ L E + + +KE + ++M E+E T + +K
Sbjct: 1244 NEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQ 1303
Query: 2421 ----LQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEI--EDLKMKL---VKIDLEK 2471
L++K+ E + E+T + +++L+ +V A+ + + ++L K+ V++ E
Sbjct: 1304 EKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKEN 1363
Query: 2472 MKNAKEFEK 2480
++ A+E EK
Sbjct: 1364 VRLAEETEK 1372
Score = 57.4 bits (137), Expect = 2e-07
Identities = 143/708 (20%), Positives = 304/708 (42%), Gaps = 101/708 (14%)
Query: 1927 KTARMLSKEHKETVDKLREKISEKTI-QISDIQKDLDKSKDELQKKIQELQKKELQLLRV 1985
+T L+ + + K + ++E T +S +Q ++ + K++L + E L R
Sbjct: 349 ETLSTLNFAQRAKLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRD 408
Query: 1986 KEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELR 2045
K KK N ME F+ L + + L +K+ + LE++ + K+ ++
Sbjct: 409 K-------KKTNYMEY----FQEAMLFFKKSEQEKKSLIEKVTQ-LEDLTL--KKEKFIQ 454
Query: 2046 RIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLK 2105
K +K DQ I L ++ R + + RLLS+ + + ++LRE+ + K
Sbjct: 455 SNKMIVKFREDQIIR-LEKLHKESRGGFLPEEQDRLLSELRNEI-QTLREQIEHHPRVAK 512
Query: 2106 RYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSME 2165
M++H L L + ++ +E+ + A L + + +EK Q S +
Sbjct: 513 Y--AMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPK 570
Query: 2166 FHR---IMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEK-QKELLIKIQHLQQDCDV 2221
+ + + + + + +I+ E + S ++E +F + K Q EL ++Q LQ
Sbjct: 571 AQKEPCLFANTEKLKAQLLQIQTELNNSKQEYE-EFKELTRKRQLELESELQSLQ----- 624
Query: 2222 PSRELRDLKLNQNMD--LHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTR 2279
K N N++ L + K S+ I E ++++ + Q L++R
Sbjct: 625 --------KANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQ-----LHSR 671
Query: 2280 FDIEKLK------NGIQKENDRICQVNNFFNNRIIAIMNES----------TEFEERSAT 2323
+ KL + +N I N+ N + MNE T E+ SA
Sbjct: 672 -PVPKLSPEMGSFGSLYTQNSSILD-NDILNEPVPPEMNEQAFEAISEELRTVQEQMSAL 729
Query: 2324 ISKEWEQDLKSLK-EKNEKLFKNYQTLKTSLASGAQVNPTTQDNK---NPHVTSRATQLT 2379
+K E++ K+LK +++ +++ T L S +++ T Q + +V + Q T
Sbjct: 730 QAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQET 789
Query: 2380 TEKIRELENSLHEAKE--SAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKE 2437
K L++ +H+ + + KE +K++ TN K K+ E + ++ +
Sbjct: 790 QTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQ--EKEFNKLSERHMHVQLQLD 847
Query: 2438 TIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKM-KNAKEFEKEISATKATVEYQKEVI 2496
+++ +K+ L +K ++ D +++K +++++ +N + F+KE K+ + E++
Sbjct: 848 NLRLENEKL-LESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELL 906
Query: 2497 RLLRE-NLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKE 2555
+E N + S Q ++ D + S+K + +L++ +KE
Sbjct: 907 EAEKERNNKLSLQFEE--------DKENSSKEIL-------------KVLEAVRQEKQKE 945
Query: 2556 ISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCE 2603
+K +QQ ++ K + LL+ + +S+ K+ R++ K+V +
Sbjct: 946 TAKCEQQMAKVQKLEESLLATEKVISSLEKS-------RDSDKKVVAD 986
Score = 46.6 bits (109), Expect = 3e-04
Identities = 131/618 (21%), Positives = 242/618 (39%), Gaps = 96/618 (15%)
Query: 2059 IATLREMIARDRQNHQVKPEKRLLSDGQQ-HLTESLREKCSRIKELLKRYSEMDDHYECL 2117
+ L+E +A + + Q PE L D ++ + E +E K+ + + + L
Sbjct: 384 VKRLKEQLA-ELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKKSLIEKVTQL 442
Query: 2118 NRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSM--EFHRIMKKLKY 2175
L+L EK I+ K M VK Q +EKL ++ + E R++ +L+
Sbjct: 443 EDLTLKKEKFIQSNK---MIVKFRED----QIIRLEKLHKESRGGFLPEEQDRLLSELRN 495
Query: 2176 VLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNM 2235
+ + + + E H + K+ M+ E+ + L R L +K Q M
Sbjct: 496 EIQTLRE-QIEHHPRVAKYAMENHSLREENRRL---------------RLLEPVKRAQEM 539
Query: 2236 DLH-IEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEND 2294
D I ++ K FSE + QQ S + + L + NT EKLK
Sbjct: 540 DAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCL--FANT----EKLKA------- 586
Query: 2295 RICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKN---EKLFK------- 2344
++ Q+ NN E EF+E + E E +L+SL++ N E L +
Sbjct: 587 QLLQIQTELNNS----KQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKR 642
Query: 2345 ---------NYQTLK--TSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEA 2393
+ +TLK T+ Q++ +P + S + L T+ L+N +
Sbjct: 643 QEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGS-LYTQNSSILDNDILNE 701
Query: 2394 KESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPY 2453
E + +EL + ++ LQAK+ E E +Q DK+ +
Sbjct: 702 PVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEE----EHKNLKLQQHVDKLEHHSTQM 757
Query: 2454 KEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLR--------- 2504
+E ++ K E + EK++ T+ ++ K + LR L
Sbjct: 758 QELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSV 817
Query: 2505 -------RSQQAQDTSVISE---HTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIR--L 2552
++ Q ++ + +SE H Q N L ++++ L ++++ +
Sbjct: 818 KLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLE---NEKLLESKACLQDSYDNLQEIM 874
Query: 2553 EKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKS-PKV 2611
+ EI +L + + K+ L S+ +L ++ KER K + ENS K KV
Sbjct: 875 KFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKV 934
Query: 2612 TGTASKKKQITPSQCKER 2629
++KQ ++C+++
Sbjct: 935 LEAVRQEKQKETAKCEQQ 952
>gi|116686122 kinesin family member 4 [Homo sapiens]
Length = 1232
Score = 328 bits (841), Expect = 4e-89
Identities = 302/1071 (28%), Positives = 500/1071 (46%), Gaps = 146/1071 (13%)
Query: 7 VAVCVRVRPLNSREESLG-ETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEE 65
V V +R RPL +E S G + + + V+ D KSF +D VF + + V+
Sbjct: 10 VRVALRCRPLVPKEISEGCQMCLSFVPGEPQVVVGTD--KSFTYDFVFDPSTEQEEVFNT 67
Query: 66 IAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGS-------EDHLGVIPRAIHDIFQKIK 118
AP+I +GYN T+ AYGQT SGKTY+M G+ E +GVIPR I +F++I
Sbjct: 68 AVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGVIPRVIQLLFKEID 127
Query: 119 KFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMA 178
K D EF L+VSY+EIYNE I DLLC +++ + IRED + + LTE+ V +
Sbjct: 128 KKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALDT 187
Query: 179 LKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAG 238
+ + +G SR T MN +SSRSH IF + LE R+K + + S S L+LVDLAG
Sbjct: 188 VSCLEQGNNSRTVASTAMNSQSSRSHAIFTISLEQRKKSD----KNSSFRSKLHLVDLAG 243
Query: 239 SERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGG 298
SER +T A G RLKEG NINR L LG VI L D + GGF+ YRDSKLTR+LQ+SLGG
Sbjct: 244 SERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGGFVPYRDSKLTRLLQDSLGG 303
Query: 299 NAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLK 356
N+ T +I ++P + +ETL L++A A+ +KN P VN + A L ++++ L+
Sbjct: 304 NSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIVN-IDPQTAELNHLKQQVQQLQ 362
Query: 357 KQLEEV------------SLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML--- 401
L + E MEK+Q L+EE + L + +E +ML
Sbjct: 363 VLLLQAHGGTLPGSITVEPSENLQSLMEKNQ--SLVEENEKLSRGLSEAAGQTAQMLERI 420
Query: 402 VTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREI 461
+ + + K + R+ C + K+ + + I +L L
Sbjct: 421 ILTEQANEKMNAKLEELRQHAACKLDLQKLVETLEDQELKENVEIICNLQQLITQL---S 477
Query: 462 DESVCSESDVFSNTLDTLSEIEWNPATK---------------LLNQENIE--------- 497
DE+V + ++ +++E +P T +++E +E
Sbjct: 478 DETVACMAAAIDTAVEQEAQVETSPETSRSSDAFTTQHALRQAQMSKELVELNKALALKE 537
Query: 498 ----------SELNSLRADYDN----LVLDYEQLRTEKEEMELKLK-EKNDLDEFEALER 542
S+L ++ Y + L L+ L+ EKEE+ L+L+ K D ++ + ER
Sbjct: 538 ALARKMTQNDSQLQPIQYQYQDNIKELELEVINLQKEKEELVLELQTAKKDANQAKLSER 597
Query: 543 KTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQK 602
+ K+ QE++ +I++LK + NE S ++L E + KL + I K
Sbjct: 598 RRKRLQELE--GQIADLKKKL-----------NEQSKLLKLKESTERTVSKLNQEIRMMK 644
Query: 603 LENIKMDLSYSLESIEDPKQMKQTLFDAETVAL---DAKRESAFLRSE-NLE-----LKE 653
+ +++ + E E +Q KQ D E + L D KR+ L+ E N + L+
Sbjct: 645 NQRVQL-MRQMKEDAEKFRQWKQKK-DKEVIQLKERDRKRQYELLKLERNFQKQSNVLRR 702
Query: 654 KMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLL 713
K +E A K++++ +Q K++ D KE QS E T +V L
Sbjct: 703 KTEEAAAANKRLKDALQ--------KQREVADKRKETQSRGMEGTA------ARVKNWLG 748
Query: 714 CNLELEGKITDLQKELNKEVEENEALREEVILLSELK-SLPSEVERLRKEIQDKSEELHI 772
+E+ + ++ LN +E+ + L ++V L E K S + +LR+ +E
Sbjct: 749 NEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQLKEKKESGENPPPKLRRRTFSLTEVRGQ 808
Query: 773 ITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQK 832
++ +D + ++ E+ ++ +I DL + +S D+ Q ++ + E K
Sbjct: 809 VSESEDSITKQIESLETEMEFRSAQIA----DLQQKLLDAESEDRPKQRWENIATILEAK 864
Query: 833 YKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQL 892
+ + + E+V+ + K +SSL KT + + + + E N ++
Sbjct: 865 CAL-----KYLIGELVSSKIQVSKLESSLKQSKTSCA-------DMQKMLFEERNHFAEI 912
Query: 893 KEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDI 952
+ +L+ ++ +EK L + L Q + KQL+ES+ + QL S
Sbjct: 913 ETELQAELVRMEQQHQEKVLYL---------LSQLQQSQMAEKQLEESVSEKEQQLLS-- 961
Query: 953 HDTVNMNIDTQEQLRNALESLKQHQETINTLKSKIS--EEVSRNLHMEENT 1001
T+ + E++R E +Q +K K++ + SR H+ ++T
Sbjct: 962 --TLKCQDEELEKMREVCEQNQQLLRENEIIKQKLTLLQVASRQKHLPKDT 1010
Score = 89.7 bits (221), Expect = 3e-17
Identities = 182/896 (20%), Positives = 366/896 (40%), Gaps = 117/896 (13%)
Query: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116
Q+L I +K + LK + + I N+E L LL +K Q + ++ IK G
Sbjct: 120 QLLFKEIDKKSDFEFTLKVSY-LEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTE 178
Query: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMS--------EMQKKINEIENLKNELK 1168
+T + L E+ + +N Q S E +KK ++ + +++L
Sbjct: 179 KTVLVALDTVSCL-EQGNNSRTVASTAMNSQSSRSHAIFTISLEQRKKSDKNSSFRSKLH 237
Query: 1169 NKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL----QKSFETERDHLRGYIR 1224
+L + + +L E + + V+ L + F RD +
Sbjct: 238 LVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGGFVPYRDSKLTRLL 297
Query: 1225 EIEATGLQTKEELKIAHIHLKEH--QETIDELR-----RSVSEKTAQIINTQDLEKSHTK 1277
+ G L IA + + +ET++ LR R + K I+ Q E +H K
Sbjct: 298 QDSLGG--NSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIVNIDPQTAELNHLK 355
Query: 1278 LQEE---IPVLHEEQELLPNVKEVSETQETMNELELLTE--QSTTKDSTTLAR------- 1325
Q + + +L LP S T E L+ L E QS +++ L+R
Sbjct: 356 QQVQQLQVLLLQAHGGTLPG----SITVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAG 411
Query: 1326 ---IEMERLRL----NEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK 1378
+ER+ L NEK EE++ + +L+ + E LE +LKE++ E +
Sbjct: 412 QTAQMLERIILTEQANEKMNAKLEELRQHAACKLDLQKLVETLE--DQELKENV-EIICN 468
Query: 1379 IQE--SQSKQEQSLNM---------KEKDNETTKIVSEMEQFKPKDSALLRIEI--EMLG 1425
+Q+ +Q E M +E ET+ S AL + ++ E++
Sbjct: 469 LQQLITQLSDETVACMAAAIDTAVEQEAQVETSPETSRSSDAFTTQHALRQAQMSKELVE 528
Query: 1426 LSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCC 1485
L+K L + + + LQ +Q Q D +KE E++ E EE +
Sbjct: 529 LNKALALKEALARKMTQNDSQLQPIQYQYQ---DNIKELELEVINLQKEKEELVLELQTA 585
Query: 1486 LKE--QEETINELRVNLSEKETEISTIQKQLEA------INDKLQNKIQEIYEKEEQFNI 1537
K+ Q + R L E E +I+ ++K+L + + + + ++ ++
Sbjct: 586 KKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIRMMKN 645
Query: 1538 KQISEVQEKVNELKQFKEHRKAKDSALQSIESK----MLELTNRLQESQEEIQIMIKEKE 1593
+++ +++ + ++F++ ++ KD + ++ + EL + Q++ ++ ++ E
Sbjct: 646 QRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTE 705
Query: 1594 EM----KRVQEALQIER---DQLKENTKE----IVAKMKESQEKEYQFLKMTA-----VN 1637
E KR+++ALQ +R D+ KE A++K E + + T +N
Sbjct: 706 EAAAANKRLKDALQKQREVADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHLN 765
Query: 1638 ETQEKMC----EIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRS 1693
+ E ++ LKE+ E+ + + LT++ + E S+TK+ + L +
Sbjct: 766 DLLEDRKILAQDVAQLKEKKESGENPPPKLRRRTFSLTEVRGQVSESEDSITKQIESLET 825
Query: 1694 VEETLKVERDQLKENLRETITRDLEKQE------------ELKIVHMHLKEHQETIDKLR 1741
E + L++ L + + D KQ LK + L + + KL
Sbjct: 826 EMEFRSAQIADLQQKLLDAESEDRPKQRWENIATILEAKCALKYLIGELVSSKIQVSKLE 885
Query: 1742 GIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKT 1801
+ + ++MQK L + + ++Q EL ++ +Q+ +K+ ++S+
Sbjct: 886 SSLKQSKTSCADMQKMLFEERNHFAEIETELQAEL------VRMEQQHQEKVLYLLSQ-L 938
Query: 1802 DKLSNMQKDLENS-NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQI 1856
+ +K LE S + K Q+ + LK + +L +++ + Q+ + E E +K+++
Sbjct: 939 QQSQMAEKQLEESVSEKEQQLLSTLKCQDEELEKMREVCEQNQQLLRENEIIKQKL 994
Score = 89.0 bits (219), Expect = 6e-17
Identities = 207/900 (23%), Positives = 382/900 (42%), Gaps = 129/900 (14%)
Query: 722 ITDLQKELNKEVEENEALREEVILLS-----ELKSLPSEVERLRKEIQDKSEEL---HII 773
I + E K+ ++N + R ++ L+ K +E +RL++ I L ++I
Sbjct: 215 IFTISLEQRKKSDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVI 274
Query: 774 TS-EKDKLFSEVVHKESRVQGLLEE-IGKTKDDLATTQSNYKSTDQEFQNFKTL-HMDFE 830
++ DK V +++S++ LL++ +G L + ++ E + TL + D
Sbjct: 275 SALGDDKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLE-ETLNTLRYADRA 333
Query: 831 QKYKMVLEEN-ERMNQEIVNLSKEAQKFDSSL---------GALKTELSYKTQELQEKTR 880
+K K N + E+ +L ++ Q+ L G++ E S Q L EK +
Sbjct: 334 RKIKNKPIVNIDPQTAELNHLKQQVQQLQVLLLQAHGGTLPGSITVEPSENLQSLMEKNQ 393
Query: 881 EVQERLNEMEQLKEQL-ENRDSTLQTVEREKTLITE----KLQQTLEEVKTLTQEKDDLK 935
+ E E E+L L E T Q +ER ++TE K+ LEE++ K DL+
Sbjct: 394 SLVE---ENEKLSRGLSEAAGQTAQMLER--IILTEQANEKMNAKLEELRQHAACKLDLQ 448
Query: 936 QLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNL 995
+L E+L E +LK ++ N+ +QL L ET+ + + I V +
Sbjct: 449 KLVETL--EDQELKENVEIICNL-----QQLITQLSD-----ETVACMAAAIDTAVEQEA 496
Query: 996 HMEEN--TGETKDEF-----------QQKMVGIDK----KQDLEAKNTQT------LTAD 1032
+E + T + D F +++V ++K K+ L K TQ +
Sbjct: 497 QVETSPETSRSSDAFTTQHALRQAQMSKELVELNKALALKEALARKMTQNDSQLQPIQYQ 556
Query: 1033 VKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGD 1092
+DN I E + ++ +L +EK EL +LE A+K+ + L E ++ EL
Sbjct: 557 YQDN-IKELELEVINLQKEKEEL--VLELQTAKKDANQAKLSERRRKRLQ---ELEGQIA 610
Query: 1093 ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE 1152
+LKK+ E++ +K + RT +L + +K + QL + ++ + ++
Sbjct: 611 DLKKK----LNEQSKLLKLKESTERTVSKLNQEIRMMKNQRVQLMRQMKE--DAEKFRQW 664
Query: 1153 MQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSF 1212
QKK E+ LK + ++ L +E + + L EE + K K LQK
Sbjct: 665 KQKKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLK--DALQKQR 722
Query: 1213 ETERDHLRGYIREIEATGLQTKE------ELKIAHIHLKEHQETIDELRRSVSEKTAQII 1266
E R +E T + K E+ ++ K H + E R+ +++ AQ
Sbjct: 723 EVADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQ-- 780
Query: 1267 NTQDLEKSHTKLQEEIPVLHEEQELLPNVK-EVSETQETMNELELLTEQSTTKDSTTLAR 1325
L++ + P L L V+ +VSE+++++ + E S +A
Sbjct: 781 ----LKEKKESGENPPPKLRRRTFSLTEVRGQVSESEDSITKQIESLETEMEFRSAQIAD 836
Query: 1326 IEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETL-AKIQESQS 1384
++ + L ES++ K + +N+ TI EA LK I E + +KIQ S
Sbjct: 837 LQQKLLD-----AESEDRPK---QRWENIATILEA----KCALKYLIGELVSSKIQ--VS 882
Query: 1385 KQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK 1444
K E SL K ++T+ + F+ ++ IE E+ R+++ H E K
Sbjct: 883 KLESSL----KQSKTSCADMQKMLFEERNH-FAEIETELQAELVRMEQQHQE-----KVL 932
Query: 1445 DDLQRLQEVLQSESDQLKENIKEIVAKHLET----EEELKVAHCCLKEQEETINELRVNL 1500
L +LQ+ +E QL+E++ E + L T +EEL+ ++ ++ + E + +
Sbjct: 933 YLLSQLQQSQMAEK-QLEESVSEKEQQLLSTLKCQDEELEKMREVCEQNQQLLRENEI-I 990
Query: 1501 SEKETEISTIQKQLEAINDKL---QNKIQEIYEKEEQFNIKQ-ISEVQEKVNELKQFKEH 1556
+K T + +Q D L + + + K + +K+ E + +LK EH
Sbjct: 991 KQKLTLLQVASRQKHLPKDTLLSPDSSFEYVPPKPKPSRVKEKFLEQSMDIEDLKYCSEH 1050
Score = 85.9 bits (211), Expect = 5e-16
Identities = 161/749 (21%), Positives = 318/749 (42%), Gaps = 89/749 (11%)
Query: 473 SNTLDTLSEIEW-NPATKLLNQE--NIE---SELNSLRADYDNLVLDYEQ---------L 517
SN +TL+ + + + A K+ N+ NI+ +ELN L+ L + Q +
Sbjct: 318 SNLEETLNTLRYADRARKIKNKPIVNIDPQTAELNHLKQQVQQLQVLLLQAHGGTLPGSI 377
Query: 518 RTEKEEMELKLKEKND--LDEFEALERKTKK--DQEMQLIHEISNLKNLVKHAEVYNQDL 573
E E L EKN ++E E L R + Q Q++ I + +
Sbjct: 378 TVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERI-----------ILTEQA 426
Query: 574 ENELSSKVELLREKED---QIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630
++++K+E LR+ ++KL E ++ Q+L+ ++E I + +Q+ L D
Sbjct: 427 NEKMNAKLEELRQHAACKLDLQKLVETLEDQELKE-------NVEIICNLQQLITQLSDE 479
Query: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690
+ A ++A + +E + + + L Q+Q+ K V+L K L
Sbjct: 480 TVACMAAAIDTAVEQEAQVETSPETSRSSDAFTTQH---ALRQAQMS---KELVELNKAL 533
Query: 691 QSAFNEITKLTSLIDGKVP-----KDLLCNLELEGKITDLQKELNKEVEENEALREEVIL 745
K+T P +D + LELE + +LQKE + V E + +++
Sbjct: 534 ALKEALARKMTQNDSQLQPIQYQYQDNIKELELE--VINLQKEKEELVLELQTAKKDANQ 591
Query: 746 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 805
+ ++ L +I D ++L+ E+ KL E V L +EI K+
Sbjct: 592 AKLSERRRKRLQELEGQIADLKKKLN----EQSKLLKLKESTERTVSKLNQEIRMMKNQR 647
Query: 806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ-EIVNLSKEAQKFDSSLGAL 864
K ++F+ +K + K + L+E +R Q E++ L + QK + L
Sbjct: 648 VQLMRQMKEDAEKFRQWKQK----KDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRK 703
Query: 865 KTELSYKTQELQE---KTREVQERLNEME---------QLKEQLENRDSTLQTVEREKTL 912
E + + L++ K REV ++ E + ++K L N + + E K
Sbjct: 704 TEEAAAANKRLKDALQKQREVADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAK-- 761
Query: 913 ITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES 972
L LE+ K L Q+ LK+ +ES + +L+ + + Q+ + +S
Sbjct: 762 --RHLNDLLEDRKILAQDVAQLKEKKESGENPPPKLRRRTFSLT----EVRGQVSESEDS 815
Query: 973 LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTAD 1032
+ + E++ T S +++ +L + E++D +Q+ I LEAK
Sbjct: 816 ITKQIESLETEMEFRSAQIA-DLQQKLLDAESEDRPKQRWENI--ATILEAKCALKYLIG 872
Query: 1033 VKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE---QLKTDLK-ENIEMTIENQEELR 1088
+ I+ + SL Q K M + + E+ +++T+L+ E + M ++QE++
Sbjct: 873 ELVSSKIQVSKLESSLKQSKTSCADMQKMLFEERNHFAEIETELQAELVRMEQQHQEKVL 932
Query: 1089 LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQE 1148
L +L++ Q Q + +KE +L T E EK++E +Q Q+ ++ +++
Sbjct: 933 YLLSQLQQSQMAEKQLEESVSEKEQQLLSTLKCQDEELEKMREVCEQNQQLLRENEIIKQ 992
Query: 1149 EMSEMQKKINEIENLKNELKNKELTLEHM 1177
+++ +Q + K+ L + + + E++
Sbjct: 993 KLTLLQVASRQKHLPKDTLLSPDSSFEYV 1021
Score = 71.6 bits (174), Expect = 1e-11
Identities = 191/961 (19%), Positives = 393/961 (40%), Gaps = 168/961 (17%)
Query: 1779 AHMHLKEQQETIDKLRGIVSEKT-----DKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
A ++++E + K+ G+ +EKT D +S +++ NS + + H +
Sbjct: 159 AQINIREDPKEGIKIVGL-TEKTVLVALDTVSCLEQG-NNSRTVASTAMNSQSSRSHAIF 216
Query: 1834 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN 1893
T+ +EQ KK K+ S SKL + +L E K E D
Sbjct: 217 TIS------------LEQRKKSDKNSSFR-SKLHLVDL-------AGSERQKKTKAEGD- 255
Query: 1894 LRRVEETLKLERDQLK-----ESLQETKARDLEIQQELKTARMLS--------------- 1933
R++E + + R L +L + K ++ K R+L
Sbjct: 256 --RLKEGININRGLLCLGNVISALGDDKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACV 313
Query: 1934 ----KEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989
+ET++ LR + I+ I ++D EL Q++Q+ ++ LL+
Sbjct: 314 SPADSNLEETLNTLRYADRARKIKNKPIV-NIDPQTAELNHLKQQVQQLQVLLLQAHGGT 372
Query: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE 2049
+ E L+ E QS+ +N +L++ L E+ + L RI
Sbjct: 373 LPGSITVEPSENLQSLMEKN----QSLVEENEKLSRGLSEA------AGQTAQMLERIIL 422
Query: 2050 SLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDG--QQHLTESLREKCSRIKELLKRY 2107
+ + ++ A L E+ RQ+ K + + L + Q L E++ C+ +++L+ +
Sbjct: 423 T-EQANEKMNAKLEEL----RQHAACKLDLQKLVETLEDQELKENVEIICN-LQQLITQL 476
Query: 2108 SEMDDHYECLNRL---SLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSM 2164
S D+ C+ +++ E ++E E S A + L+ + K +
Sbjct: 477 S--DETVACMAAAIDTAVEQEAQVETSPETSRSSDAFTTQHALRQAQMSKELVELNKALA 534
Query: 2165 EFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSR 2224
+ +K+ S + I+ + ++I + E++ I+ ++++EL++++Q ++D +
Sbjct: 535 LKEALARKMTQNDSQLQPIQYQYQDNIKELELEVINLQKEKEELVLELQTAKKDANQAKL 594
Query: 2225 ELRDLKLNQNMDLHIEEILKDFSE-SEFPSIKTEFQQVLSN-----RKEMTQFLEEWLNT 2278
R K Q ++ I ++ K +E S+ +K ++ +S R Q ++
Sbjct: 595 SERRRKRLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIRMMKNQRVQLMRQM 654
Query: 2279 RFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEK 2338
+ D EK + QK++ + Q+ R ++ F+++S + ++ E+ + K
Sbjct: 655 KEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRL 714
Query: 2339 NEKLFKNYQT------------------LKTSLASGAQVNPTTQDNK---NPHVTSR--- 2374
+ L K + +K L + +V +T++ K N + R
Sbjct: 715 KDALQKQREVADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHLNDLLEDRKIL 774
Query: 2375 ---ATQLTTEK---------IRELENSLHEAKESAMHKESKIIK----MQKELEVTNDII 2418
QL +K +R SL E + E I K ++ E+E + I
Sbjct: 775 AQDVAQLKEKKESGENPPPKLRRRTFSLTEVRGQVSESEDSITKQIESLETEMEFRSAQI 834
Query: 2419 AKLQAKVHES---NKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNA 2475
A LQ K+ ++ ++ ++ + +L+ K AL K E+ K+++ K++ +K +
Sbjct: 835 ADLQQKLLDAESEDRPKQRWENIATILEAKCAL--KYLIGELVSSKIQVSKLE-SSLKQS 891
Query: 2476 KE---------FEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNK 2526
K FE+ + E Q E++R+ +++ Q + ++S+ Q + K
Sbjct: 892 KTSCADMQKMLFEERNHFAEIETELQAELVRMEQQH-----QEKVLYLLSQLQQSQMAEK 946
Query: 2527 PLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKT 2586
L +S + ++ +S LK Q+E+L K + E+ NQ L E +
Sbjct: 947 QLE----------------ESVSEKEQQLLSTLKCQDEELEKMR-EVCEQNQQLLRENEI 989
Query: 2587 WKER-TLKREAHKQVTCENSPKSPKVTGTASKK---KQITPSQCKERNLQDPVPKESPKS 2642
K++ TL + A +Q ++ PK ++ +S + + PS+ KE+ L+ + E K
Sbjct: 990 IKQKLTLLQVASRQ---KHLPKDTLLSPDSSFEYVPPKPKPSRVKEKFLEQSMDIEDLKY 1046
Query: 2643 C 2643
C
Sbjct: 1047 C 1047
Score = 66.6 bits (161), Expect = 3e-10
Identities = 144/787 (18%), Positives = 309/787 (39%), Gaps = 115/787 (14%)
Query: 1738 DKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIV 1797
D+ R I ++ I +L H LK Q ++Q L AH T++
Sbjct: 331 DRARKIKNKPIVNIDPQTAELNH----LKQQVQQLQVLLLQAHGGTLPGSITVEP----- 381
Query: 1798 SEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQL---ITLKKDVNETQK-KVSEMEQLK 1853
SE L + L N KL + E Q+ I L + NE K+ E+ Q
Sbjct: 382 SENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHA 441
Query: 1854 KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN--LRRVEETLKLERDQLKES 1911
D + LE + L ++ NL+++ + + + + +T + Q++ S
Sbjct: 442 ACKLDLQKLVETLEDQELKENVEIICNLQQLITQLSDETVACMAAAIDTAVEQEAQVETS 501
Query: 1912 LQETKARDLEIQQELKTARMLSKEHKET------VDKLREKISEKTIQISDIQKDLDKSK 1965
+ +++ D Q +SKE E + L K+++ Q+ IQ +
Sbjct: 502 PETSRSSDAFTTQHALRQAQMSKELVELNKALALKEALARKMTQNDSQLQPIQYQYQDNI 561
Query: 1966 DELQKKIQELQKKE----LQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNF 2021
EL+ ++ LQK++ L+L K+D N + K E + +Q +
Sbjct: 562 KELELEVINLQKEKEELVLELQTAKKDANQA-----------KLSERRRKRLQELEGQIA 610
Query: 2022 QLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRL 2081
L KKL+E + +++ + ++ + ++M ++Q + +R+M + Q K +K
Sbjct: 611 DLKKKLNEQSKLLKLKESTERTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQKK-- 668
Query: 2082 LSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLD-------LEKEIEFQKEL 2134
+ + + R ELLK L R + + L+ ++ Q+E+
Sbjct: 669 ----DKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQREV 724
Query: 2135 SMRVKANLSLPYLQTKHIEKLFTAN--------QRCSMEFHRIMKKLKYVLSYVTKIKEE 2186
+ + K S T K + N + + +++ K + V ++KE+
Sbjct: 725 ADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQLKEK 784
Query: 2187 QHESIN-----KFEMDFIDEV-----EKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMD 2236
+ N + + EV E + + +I+ L+ + + S ++ DL
Sbjct: 785 KESGENPPPKLRRRTFSLTEVRGQVSESEDSITKQIESLETEMEFRSAQIADL------- 837
Query: 2237 LHIEEILKDFSESEFPSIKTE-FQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDR 2295
++ L D + P + E +L + + + E ++++ + KL++ +++
Sbjct: 838 ---QQKLLDAESEDRPKQRWENIATILEAKCALKYLIGELVSSKIQVSKLESSLKQSKTS 894
Query: 2296 ICQVNNFFNNRIIAIMNESTEFEERS--ATISKEWEQDLKSLKEKN-EKLFKNYQTLKTS 2352
+ FEER+ A I E + +L +++++ EK+ L+ S
Sbjct: 895 CADMQKML-------------FEERNHFAEIETELQAELVRMEQQHQEKVLYLLSQLQQS 941
Query: 2353 LASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELE 2412
+ Q+ + +EK ++L ++L + ++ + K ++ + ++L
Sbjct: 942 QMAEKQLE----------------ESVSEKEQQLLSTL-KCQDEELEKMREVCEQNQQLL 984
Query: 2413 VTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVK--IDLE 2470
N+II + + +++ K+T+ L + P K + +K K ++ +D+E
Sbjct: 985 RENEIIKQKLTLLQVASRQKHLPKDTL--LSPDSSFEYVPPKPKPSRVKEKFLEQSMDIE 1042
Query: 2471 KMKNAKE 2477
+K E
Sbjct: 1043 DLKYCSE 1049
>gi|150010604 kinesin family member 4B [Homo sapiens]
Length = 1234
Score = 320 bits (821), Expect = 9e-87
Identities = 299/1031 (29%), Positives = 482/1031 (46%), Gaps = 127/1031 (12%)
Query: 7 VAVCVRVRPLNSREESLG-ETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEE 65
V V +R RPL +E S G + + + V+ D KSF +D VF + V+ +
Sbjct: 10 VRVALRCRPLVPKEISEGCQMCLSFVPGETQVVVGTD--KSFTYDFVFDPCTEQEEVFNK 67
Query: 66 IAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGS-------EDHLGVIPRAIHDIFQKIK 118
AP+I +GYN T+ AYGQT SGKTY+M G+ E +G+IPR I +F++I
Sbjct: 68 AVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGIIPRVIQLLFKEID 127
Query: 119 KFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMA 178
K D EF L+VSY+EIYNE I DLLC +++ + IRED + + LTE+ V +
Sbjct: 128 KKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALDT 187
Query: 179 LKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAG 238
+ + +G SR T MN +SSRSH IF + +E R+K + NC S L+LVDLAG
Sbjct: 188 VSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKSD-KNCSFR---SKLHLVDLAG 243
Query: 239 SERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGG 298
SER +T A G RLKEG NINR L LG VI L D + G F+ YRDSKLTR+LQ+SLGG
Sbjct: 244 SERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGSFVPYRDSKLTRLLQDSLGG 303
Query: 299 NAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLK 356
N+ T +I ++P + +ETL+ L++A A+ +KN P VN + A L ++++ L+
Sbjct: 304 NSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVN-IDPHTAELNHLKQQVQQLQ 362
Query: 357 KQLEEV------------SLETRAQAMEKDQLAQLLEEKD----LLQKVQNEKIENLTRM 400
L + E MEK+Q L+EE + L K + + L R+
Sbjct: 363 VLLLQAHGGTLPGSINAEPSENLQSLMEKNQ--SLVEENEKLSRCLSKAAGQTAQMLERI 420
Query: 401 LVTSSSLTLQQELKAKRK--RRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLL 458
++T + ++L AK + R+ C + K+ + + I +L L
Sbjct: 421 ILTEQ---VNEKLNAKLEELRQHVACKLDLQKLVETLEDQELKENVEIICNLQQLITQL- 476
Query: 459 REIDESVCSESDVFSNTLDTLSEIEWNPATK----------LLNQENIES---ELNSLRA 505
DE+V + ++ +++E +P T L+Q + ELN+ A
Sbjct: 477 --SDETVACTAAAIDTAVEEEAQVETSPETSRSSDAFTTQHALHQAQMSKEVVELNNALA 534
Query: 506 DYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ---EMQLIHEISNLKNL 562
+ LV Q + + ++ + ++ E E + + +K++ E+Q + N L
Sbjct: 535 LKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEKEELVRELQTAKKNVNQAKL 594
Query: 563 VKHAEVYNQDLE----------NELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSY 612
+H Q+LE NE S ++L E + KL + I K + +++ +
Sbjct: 595 SEHRHKLLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIWMMKNQRVQL-MRQ 653
Query: 613 SLESIEDPKQMKQTLFDAETVAL---DAKRESAFLRSE------NLELKEKMKELATTYK 663
E E +Q KQ D E + L D KR+ L+ E + L+ K +E A K
Sbjct: 654 MKEDAEKFRQWKQKK-DKEVIQLKERDRKRQYELLKLERNFQKQSSVLRRKTEEAAAANK 712
Query: 664 QMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKIT 723
++++ +Q K++ D KE QS E I +V L +E+
Sbjct: 713 RLKDALQ--------KQREVTDKRKETQSHGKE------GIAARVRNWLGNEIEVMVSTE 758
Query: 724 DLQKELNKEVEENEALREEVILLSELK-SLPSEVERLRKEIQDKSEELHIITSEKDKLFS 782
+ ++ LN +E+ + L ++V+ L E K S + +LRK SE + +D +
Sbjct: 759 EAKRHLNDLLEDRKILAQDVVQLKEKKESRENPPPKLRKCTFSLSEVHGQVLESEDCITK 818
Query: 783 EVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT-LHMDFEQKYKM------ 835
++ E+ ++ +I + L +S + Q ++N T L KY +
Sbjct: 819 QIESLETEMELRSAQIADLQQKLLDAESEDR-PKQCWENIATILEAKCALKYLIGELVSS 877
Query: 836 -----VLEENERMNQEIV-----NLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQER 885
LE + R ++ L +E F L+ EL Q+ QEK + +
Sbjct: 878 KIHVTKLENSLRQSKASCADMQKMLFEEQNHFSEIETELQAELVRMEQQHQEKVLYLVSQ 937
Query: 886 LNEMEQLKEQLENRDSTLQTVEREKTLIT---------EKLQQTLEEVKTLTQEKDDLKQ 936
L E + ++QLE S E+E+ L++ EK+++ E+ + L QE + +KQ
Sbjct: 938 LQESQMAEKQLEKSAS-----EKEQQLVSTLQCQDEELEKMREVCEQNQQLLQENEIIKQ 992
Query: 937 LQESLQIERDQ 947
LQ+ Q
Sbjct: 993 KLILLQVASRQ 1003
Score = 97.1 bits (240), Expect = 2e-19
Identities = 171/728 (23%), Positives = 319/728 (43%), Gaps = 93/728 (12%)
Query: 473 SNTLDTLSEIEW-NPATKLLNQE--NIE---SELNSLRADYDNLVLDYEQ---------L 517
SN +TLS + + + A K+ N+ NI+ +ELN L+ L + Q +
Sbjct: 318 SNLEETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQVQQLQVLLLQAHGGTLPGSI 377
Query: 518 RTEKEEMELKLKEKND--LDEFEALERKTKK--DQEMQLIHEISNLKNLVKHAEVYNQDL 573
E E L EKN ++E E L R K Q Q++ I + + +
Sbjct: 378 NAEPSENLQSLMEKNQSLVEENEKLSRCLSKAAGQTAQMLERI-----------ILTEQV 426
Query: 574 ENELSSKVELLREK---EDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630
+L++K+E LR+ + ++KL E ++ Q+L+ ++E I + +Q+ L D
Sbjct: 427 NEKLNAKLEELRQHVACKLDLQKLVETLEDQELKE-------NVEIICNLQQLITQLSD- 478
Query: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690
ETVA A + E E E + + L+Q+Q+ K V+L L
Sbjct: 479 ETVACTAAAIDTAVEEE--AQVETSPETSRSSDAFTTQHALHQAQMS---KEVVELNNAL 533
Query: 691 QSAFNEITKLTSLIDGKVP-----KDLLCNLELEGKITDLQKELNKEVEENEALREEVIL 745
+ K+T + P +D + NLELE + +LQKE + V E + ++ V
Sbjct: 534 ALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELE--VINLQKEKEELVRELQTAKKNV-- 589
Query: 746 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 805
L +L +E++ + +L +E+ KL E V L +EI K+
Sbjct: 590 --NQAKLSEHRHKLLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIWMMKNQR 647
Query: 806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ-EIVNLSKEAQKFDSSLGAL 864
K ++F+ +K + K + L+E +R Q E++ L + QK S L
Sbjct: 648 VQLMRQMKEDAEKFRQWKQK----KDKEVIQLKERDRKRQYELLKLERNFQKQSSVLRRK 703
Query: 865 KTELSYKTQELQE---KTREVQERLNEMEQL-KEQLENRDSTLQTVEREKTLITEK---- 916
E + + L++ K REV ++ E + KE + R E E + TE+
Sbjct: 704 TEEAAAANKRLKDALQKQREVTDKRKETQSHGKEGIAARVRNWLGNEIEVMVSTEEAKRH 763
Query: 917 LQQTLEEVKTLTQEKDDLKQLQESLQIERDQLK------SDIHDTVNMNIDTQEQLRNAL 970
L LE+ K L Q+ LK+ +ES + +L+ S++H V +++++ + +
Sbjct: 764 LNDLLEDRKILAQDVVQLKEKKESRENPPPKLRKCTFSLSEVHGQV---LESEDCITKQI 820
Query: 971 ESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLT 1030
ESL+ E L+S ++ + L E+ K ++ ++ K L+ + ++
Sbjct: 821 ESLETEME----LRSAQIADLQQKLLDAESEDRPKQCWENIATILEAKCALKYLIGELVS 876
Query: 1031 ADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE---QLKTDLK-ENIEMTIENQEE 1086
+ + ++ SL Q K M + + E+ +++T+L+ E + M ++QE+
Sbjct: 877 SKIHVTKLEN------SLRQSKASCADMQKMLFEEQNHFSEIETELQAELVRMEQQHQEK 930
Query: 1087 LRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNV 1146
+ L +L++ Q Q + A +KE +L T E EK++E +Q Q+ Q+ +
Sbjct: 931 VLYLVSQLQESQMAEKQLEKSASEKEQQLVSTLQCQDEELEKMREVCEQNQQLLQENEII 990
Query: 1147 QEEMSEMQ 1154
++++ +Q
Sbjct: 991 KQKLILLQ 998
Score = 85.1 bits (209), Expect = 8e-16
Identities = 141/673 (20%), Positives = 291/673 (43%), Gaps = 97/673 (14%)
Query: 1226 IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ-----IINTQDLEKSHTKLQE 1280
I A + + L + L E E + + +TAQ I+ Q EK + KL+E
Sbjct: 377 INAEPSENLQSLMEKNQSLVEENEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEE 436
Query: 1281 ------------EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEM 1328
++ E+QEL NV+ + Q+ L+T+ S + T A I+
Sbjct: 437 LRQHVACKLDLQKLVETLEDQELKENVEIICNLQQ------LITQLSDETVACTAAAID- 489
Query: 1329 ERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQ 1388
+E+Q E T + T + AL + + + + ++ + + +E
Sbjct: 490 -----TAVEEEAQVETSPETSRSSDAFTTQHALH------QAQMSKEVVELNNALALKEA 538
Query: 1389 SLN-MKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV------A 1441
+ M + DN+ I QF+ +D+ + +E+E++ L K +E E+++ A
Sbjct: 539 LVRKMTQNDNQLQPI-----QFQYQDN-IKNLELEVINLQKEKEELVRELQTAKKNVNQA 592
Query: 1442 KEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLS 1501
K + +L + L+ + LK+ + E +K L+ +E + L ++ + RV L
Sbjct: 593 KLSEHRHKLLQELEGQIADLKKKLNE-QSKLLKLKESTERTVSKLNQEIWMMKNQRVQLM 651
Query: 1502 EKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD 1561
+ E + +Q + DK +++E K + +K Q++ + L++ E A +
Sbjct: 652 RQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSSVLRRKTEEAAAAN 711
Query: 1562 SALQSIESKMLELTNRLQESQ----------------EEIQIMIKEKEEMKRVQEALQIE 1605
L+ K E+T++ +E+Q EI++M+ +E + + + L+ +
Sbjct: 712 KRLKDALQKQREVTDKRKETQSHGKEGIAARVRNWLGNEIEVMVSTEEAKRHLNDLLE-D 770
Query: 1606 RDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIET 1665
R L ++ ++ K KES+E L+ K F +++ + +E+
Sbjct: 771 RKILAQDVVQLKEK-KESRENPPPKLR-----------------KCTFSLSEVHGQVLES 812
Query: 1666 ENIRLTQILHENLE-EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELK 1724
E+ QI E+LE EM + + DL+ ++ L E + + E I LE + LK
Sbjct: 813 EDCITKQI--ESLETEMELRSAQIADLQ--QKLLDAESEDRPKQCWENIATILEAKCALK 868
Query: 1725 IVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLK 1784
+ L + + KL + + ++MQK L + + ++Q EL ++
Sbjct: 869 YLIGELVSSKIHVTKLENSLRQSKASCADMQKMLFEEQNHFSEIETELQAEL------VR 922
Query: 1785 EQQETIDKLRGIVSEKTDKLSNMQKDLENS-NAKLQEKIQELKANEHQLITLKKDVNETQ 1843
+Q+ +K+ +VS+ + +K LE S + K Q+ + L+ + +L +++ + Q
Sbjct: 923 MEQQHQEKVLYLVSQLQES-QMAEKQLEKSASEKEQQLVSTLQCQDEELEKMREVCEQNQ 981
Query: 1844 KKVSEMEQLKKQI 1856
+ + E E +K+++
Sbjct: 982 QLLQENEIIKQKL 994
Score = 77.8 bits (190), Expect = 1e-13
Identities = 181/895 (20%), Positives = 367/895 (41%), Gaps = 131/895 (14%)
Query: 728 ELNKEVEENEALREEVILLS-----ELKSLPSEVERLRKEIQDKSEEL---HIITS-EKD 778
E K+ ++N + R ++ L+ K +E +RL++ I L ++I++ D
Sbjct: 221 EQRKKSDKNCSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDD 280
Query: 779 KLFSEVVHKESRVQGLLEE-IGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVL 837
K S V +++S++ LL++ +G L + ++ E + D +K K
Sbjct: 281 KKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKP 340
Query: 838 EEN-ERMNQEIVNLSKEAQKFDSSL---------GALKTELSYKTQELQEKTREVQERLN 887
N + E+ +L ++ Q+ L G++ E S Q L EK + + E
Sbjct: 341 IVNIDPHTAELNHLKQQVQQLQVLLLQAHGGTLPGSINAEPSENLQSLMEKNQSLVE--- 397
Query: 888 EMEQLKEQLENR-DSTLQTVERE--KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE 944
E E+L L T Q +ER + EKL LEE++ K DL++L E+L E
Sbjct: 398 ENEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEELRQHVACKLDLQKLVETL--E 455
Query: 945 RDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGET 1004
+LK ++ N+ +QL L ET+ + I V EE ET
Sbjct: 456 DQELKENVEIICNL-----QQLITQLSD-----ETVACTAAAIDTAVE-----EEAQVET 500
Query: 1005 KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM------ 1058
E + + L ++ +N + ++ + + Q N+LQ +
Sbjct: 501 SPETSRSSDAFTTQHALHQAQMSKEVVEL-NNALALKEALVRKMTQNDNQLQPIQFQYQD 559
Query: 1059 ----LESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQ--EKNHAIKKE 1112
LE + ++ K +L ++ +N + +L K QE+ Q + + ++
Sbjct: 560 NIKNLELEVINLQKEKEELVRELQTAKKNVNQAKLSEHRHKLLQELEGQIADLKKKLNEQ 619
Query: 1113 GELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEM-----QKKINEIENLKNEL 1167
+L + + KL ++ ++ ++ QL+ +E +E QKK E+ LK
Sbjct: 620 SKLLKLKESTERTVSKLNQEIWMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERD 679
Query: 1168 KNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIE 1227
+ ++ L +E + + L EE + K K + Q+ +R + + +E
Sbjct: 680 RKRQYELLKLERNFQKQSSVLRRKTEEAAAANKRLKDALQKQREVTDKRKETQSHGKEGI 739
Query: 1228 A----TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQD--------LEKSH 1275
A L + E+ ++ K H + E R+ +++ Q+ ++ L K
Sbjct: 740 AARVRNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVVQLKEKKESRENPPPKLRKCT 799
Query: 1276 TKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNE 1335
L E + E ++ + E ET+ + ++ Q D+ + +
Sbjct: 800 FSLSEVHGQVLESEDCITKQIESLETEMELRSAQIADLQQKLLDAES-----------ED 848
Query: 1336 KFQESQEEIKSLTKERDNLKTIKEAL---EVKHDQLKEHIRETLAKIQESQSKQEQSLNM 1392
+ ++ E I ++ + + LK + L ++ +L+ +R++ A + Q +
Sbjct: 849 RPKQCWENIATILEAKCALKYLIGELVSSKIHVTKLENSLRQSKASCADMQKM------L 902
Query: 1393 KEKDNETTKIVSEMEQFKPKDSALLRIEIE----MLGLSKRLQES---HDEMKSVAKEKD 1445
E+ N ++I +E++ + L+R+E + +L L +LQES +++ A EK+
Sbjct: 903 FEEQNHFSEIETELQ------AELVRMEQQHQEKVLYLVSQLQESQMAEKQLEKSASEKE 956
Query: 1446 DLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKET 1505
Q+L LQ + ++L E ++E+ ++ + L ++ E I + + L
Sbjct: 957 --QQLVSTLQCQDEEL-EKMREVCEQNQQ-----------LLQENEIIKQKLILL----- 997
Query: 1506 EISTIQKQLEAINDKL---QNKIQEIYEKEEQFNIKQ-ISEVQEKVNELKQFKEH 1556
++++ QK L ND L + + I K + +K+ E + +LK EH
Sbjct: 998 QVASRQKHLP--NDTLLSPDSSFEYIPPKPKPSRVKEKFLEQSMDIEDLKYCSEH 1050
Score = 60.8 bits (146), Expect = 2e-08
Identities = 125/665 (18%), Positives = 278/665 (41%), Gaps = 79/665 (11%)
Query: 1798 SEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQL---ITLKKDVNETQKKVSEMEQLKK 1854
SE L + L N KL + + Q+ I L + VNE K +++E+L++
Sbjct: 382 SENLQSLMEKNQSLVEENEKLSRCLSKAAGQTAQMLERIILTEQVNE--KLNAKLEELRQ 439
Query: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLR--------RVEETLKLERD 1906
+ + L L KL +E L Q+L EN+E + ++ + L +T E
Sbjct: 440 HVACK-LDLQKL-VETLE-DQELKENVEIICNLQQLITQLSDETVACTAAAIDTAVEEEA 496
Query: 1907 QLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR------EKISEKTIQISDIQKD 1960
Q++ S + +++ D Q +SKE E + L K+++ Q+ IQ
Sbjct: 497 QVETSPETSRSSDAFTTQHALHQAQMSKEVVELNNALALKEALVRKMTQNDNQLQPIQFQ 556
Query: 1961 LDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDN 2020
+ L+ ++ LQK++ +L+R ++ + K +N+ K E ++ +Q +
Sbjct: 557 YQDNIKNLELEVINLQKEKEELVR---ELQTAKKNVNQA----KLSEHRHKLLQELEGQI 609
Query: 2021 FQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEK- 2079
L KKL+E + +++ + ++ + + M ++Q + +R+M + Q K +K
Sbjct: 610 ADLKKKLNEQSKLLKLKESTERTVSKLNQEIWMMKNQRVQLMRQMKEDAEKFRQWKQKKD 669
Query: 2080 ------RLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEF--- 2130
+ +Q+ L + +L+R +E + RL L+K+ E
Sbjct: 670 KEVIQLKERDRKRQYELLKLERNFQKQSSVLRRKTE--EAAAANKRLKDALQKQREVTDK 727
Query: 2131 QKELSMRVKANLSLPYLQTKHIE-KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHE 2189
+KE K ++ E ++ + + + +++ K + V ++KE++
Sbjct: 728 RKETQSHGKEGIAARVRNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVVQLKEKKES 787
Query: 2190 SIN--------KFEMDFI--DEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHI 2239
N F + + +E + + +I+ L+ + ++ S ++ DL+
Sbjct: 788 RENPPPKLRKCTFSLSEVHGQVLESEDCITKQIESLETEMELRSAQIADLQ--------- 838
Query: 2240 EEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQV 2299
+++L SE +L + + + E ++++ + KL+N +++ +
Sbjct: 839 QKLLDAESEDRPKQCWENIATILEAKCALKYLIGELVSSKIHVTKLENSLRQSKASCADM 898
Query: 2300 NNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKN-EKLFKNYQTLKTSLASGAQ 2358
+ E F E I E + +L +++++ EK+ L+ S + Q
Sbjct: 899 QKM-------LFEEQNHFSE----IETELQAELVRMEQQHQEKVLYLVSQLQESQMAEKQ 947
Query: 2359 VNPTTQDNKNPHV-TSRATQLTTEKIREL-ENSLHEAKESAMHKESKIIKMQ---KELEV 2413
+ + + + V T + EK+RE+ E + +E+ + K+ K+I +Q ++ +
Sbjct: 948 LEKSASEKEQQLVSTLQCQDEELEKMREVCEQNQQLLQENEIIKQ-KLILLQVASRQKHL 1006
Query: 2414 TNDII 2418
ND +
Sbjct: 1007 PNDTL 1011
Score = 54.3 bits (129), Expect = 2e-06
Identities = 158/791 (19%), Positives = 323/791 (40%), Gaps = 142/791 (17%)
Query: 1791 DKLRGIVSEKTDKLSNMQKDLENSNA-------------KLQEKIQELKANEHQLITLKK 1837
DK V + KL+ + +D N+ L+E + L+ + K
Sbjct: 280 DKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNK 339
Query: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH-ENLEEMKSVMKERDNLRR 1896
+ +E+ LK+Q+ Q L + L+ L ++ E E ++S+M++ +L
Sbjct: 340 PIVNIDPHTAELNHLKQQV--QQLQVLLLQAHGGTLPGSINAEPSENLQSLMEKNQSL-- 395
Query: 1897 VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISD 1956
VEE KL R K + Q TA+ML E +++ EK++ K + +
Sbjct: 396 VEENEKLSRCLSKAAGQ--------------TAQML--ERIILTEQVNEKLNAK---LEE 436
Query: 1957 IQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSV 2016
+++ + K +LQK ++ L+ +EL KE+V + I ++QL Q + ++ +
Sbjct: 437 LRQHV-ACKLDLQKLVETLEDQEL-----KENVEI----ICNLQQLITQLSDETVACTAA 486
Query: 2017 RMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVK 2076
+D +E +++ S + R T + + + + + +V
Sbjct: 487 AIDTAV-------------------EEEAQVETSPETSRSSDAFTTQHALHQAQMSKEVV 527
Query: 2077 PEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSM 2136
L+ ++ L + + ++++ + +Y + + E L ++L EKE E +EL
Sbjct: 528 ELNNALAL-KEALVRKMTQNDNQLQPIQFQYQDNIKNLE-LEVINLQKEKE-ELVRELQT 584
Query: 2137 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM 2196
K N++ L ++H KL Q + + KKL S + K+KE +++K
Sbjct: 585 -AKKNVNQAKL-SEHRHKLL---QELEGQIADLKKKLNEQ-SKLLKLKESTERTVSKLNQ 638
Query: 2197 DF-------IDEVEKQKELLIKIQHLQQDCDVPSRELRD---------LKLNQNMDLHIE 2240
+ + + + KE K + +Q D +L++ LKL +N
Sbjct: 639 EIWMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQ-S 697
Query: 2241 EILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVN 2300
+L+ +E E + + L ++E+T +E + K GI +V
Sbjct: 698 SVLRRKTE-EAAAANKRLKDALQKQREVTDKRKETQSHG------KEGIA------ARVR 744
Query: 2301 NFFNNRIIAIMNESTEFEERSATISKE----WEQDLKSLKEKNEKLFKNYQTLKTSLASG 2356
N+ N I ++ STE +R E QD+ LKEK E L+ S
Sbjct: 745 NWLGNEIEVMV--STEEAKRHLNDLLEDRKILAQDVVQLKEKKESRENPPPKLRKCTFSL 802
Query: 2357 AQVNPTTQDNKNPHVTSRATQLTTE------KIRELENSLHEAKESAMHKE-----SKII 2405
++V+ ++++ +T + L TE +I +L+ L +A+ K+ + I+
Sbjct: 803 SEVHGQVLESEDC-ITKQIESLETEMELRSAQIADLQQKLLDAESEDRPKQCWENIATIL 861
Query: 2406 KMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLV 2465
+ + L+ + + V + L ++K + +Q + + E +L+ +LV
Sbjct: 862 EAKCALKYLIGELVSSKIHVTKLENSLRQSKASCADMQKMLFEEQNHFSEIETELQAELV 921
Query: 2466 KIDLEKMKNA--------------KEFEKEISATK----ATVEYQKEVIRLLRENLRRSQ 2507
+++ + + K+ EK S + +T++ Q E + +RE ++Q
Sbjct: 922 RMEQQHQEKVLYLVSQLQESQMAEKQLEKSASEKEQQLVSTLQCQDEELEKMREVCEQNQ 981
Query: 2508 Q-AQDTSVISE 2517
Q Q+ +I +
Sbjct: 982 QLLQENEIIKQ 992
Score = 44.7 bits (104), Expect = 0.001
Identities = 74/450 (16%), Positives = 186/450 (41%), Gaps = 45/450 (10%)
Query: 2149 TKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEE--QHESINKFEMDFIDEVEKQK 2206
+++++ L NQ E ++ + L ++ E E +N+ ++E+ +
Sbjct: 382 SENLQSLMEKNQSLVEENEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEELRQHV 441
Query: 2207 ELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRK 2266
+ +Q L V + E ++LK N + ++++++ S+ +
Sbjct: 442 ACKLDLQKL-----VETLEDQELKENVEIICNLQQLITQLSDETVACTAAAIDTAVEEEA 496
Query: 2267 EMTQFLEEWLNT-RFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATIS 2325
++ E ++ F + + Q + + ++NN + A++ + T+ + + I
Sbjct: 497 QVETSPETSRSSDAFTTQHALHQAQMSKE-VVELNNALALKE-ALVRKMTQNDNQLQPIQ 554
Query: 2326 KEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRE 2385
+++ ++K+L+ + L K + L L T + N N ++ ++ + ++E
Sbjct: 555 FQYQDNIKNLELEVINLQKEKEELVRELQ-------TAKKNVNQ---AKLSEHRHKLLQE 604
Query: 2386 LENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDK 2445
LE + + K+ ++++SK++K+++ E T ++KL ++ + ++ +K
Sbjct: 605 LEGQIADLKKK-LNEQSKLLKLKESTERT---VSKLNQEIWMMKNQRVQLMRQMKEDAEK 660
Query: 2446 VALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR 2505
+ +E+ LK + K E +K + F+K+ S + E + L++ L++
Sbjct: 661 FRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSSVLRRKTEEAAAANKRLKDALQK 720
Query: 2506 SQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQ 2565
++ D K G GI + + + + E +K
Sbjct: 721 QREVTD------------KRKETQSHGKEGIAARVRNWLGNEIEVMVSTEEAK------- 761
Query: 2566 LIKQKNELLSNNQHLSNEVKTWKERTLKRE 2595
+ N+LL + + L+ +V KE+ RE
Sbjct: 762 --RHLNDLLEDRKILAQDVVQLKEKKESRE 789
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 311 bits (798), Expect = 4e-84
Identities = 473/2167 (21%), Positives = 962/2167 (44%), Gaps = 290/2167 (13%)
Query: 454 SINLLREIDESVCS---ESDVFSNTLDTLSEIEWNPATKLLNQ-ENIESELNSLRADYDN 509
S+N L ++D S S SD+ S D + + +L+ + +E L+S R Y
Sbjct: 101 SLNRL-DLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSE 159
Query: 510 LVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVY 569
LV Y+ L+ EK++++ L + D ++L R + +E+Q+ + KH
Sbjct: 160 LVTAYQMLQREKKKLQGILSQSQD----KSLRRIAELREELQMDQQAK------KH---- 205
Query: 570 NQDLENELSSKVELLREKEDQIKKLQEYID--SQKLEN--IKMDLSYSLESIEDPKQMKQ 625
L+ E + +E EK+ I LQ + Q+L N + +D+ L +E ++
Sbjct: 206 ---LQEEFDASLE---EKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFT 259
Query: 626 TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD 685
+ E+ + +++ L++++K K+ + IQ ++ Q +
Sbjct: 260 KEENPESDGEPVVEDGTSVKTLET-LQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEA 318
Query: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL 745
L+++L E+ K+ L + K + + + I L+++ + E + E +
Sbjct: 319 LQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLE 378
Query: 746 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 805
+ E E+ +LR I+ +T++ ++L + KE + EE+ K
Sbjct: 379 MKE-----EEIAQLRSRIKQ-------MTTQGEELREQ---KEKSERAAFEELEKALSTA 423
Query: 806 ATTQSNYKSTDQEF-QNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFD-SSLGA 863
T+ + E + KT+ E++ + +E R+ QE+V++ K++ + + L
Sbjct: 424 QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK 483
Query: 864 L-KTELSYKTQELQEKTREVQERLNEM-EQLKEQLENRDSTLQTVEREK----TLITEKL 917
L + EL+ K QEL T+++Q R E EQ+K LE S + +EK +L E+L
Sbjct: 484 LHEKELARKEQEL---TKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540
Query: 918 QQTLEEVKTLTQEKDDLKQLQESLQIERD---QLKSDIHDTVNMNIDTQEQLRNALESLK 974
+ L++ LT+ ++ L+ LQ+ + R +L+S + ++ N + + L LE+ K
Sbjct: 541 E--LQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEK 598
Query: 975 -QHQETINTLKSKISEEVSRNLHMEENTGETKDEF--QQKMVGIDKKQDLEAKNTQTLTA 1031
+H + I + K E+ H ++ K + QQ ++K ++ + +TL
Sbjct: 599 NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETL-- 656
Query: 1032 DVKDNEIIEQQRKIFSLIQEKNELQ-QMLESVIAEKEQLKTDLKENIEMTIENQEELRLL 1090
+KD EII Q I+E NE + L+ E E L ++L E ++ + +EEL +L
Sbjct: 657 -LKDKEIIFQAH-----IEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL 710
Query: 1091 GDELKK-QQEIVA---QEKNH------AIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ 1140
D+ K +QE+ A ++KNH +I KE E+S + E+ LK++ QL+
Sbjct: 711 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVS-----IQRTEKALKDQINQLE--- 762
Query: 1141 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK 1200
L ++E +++ +ENL+ ++K E L+ + + +E+ K+ +
Sbjct: 763 ---LLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
Query: 1201 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
+ L++ ETER L + E+EA EL I +++ + +++ + +
Sbjct: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ 879
Query: 1261 KTAQIINTQD--LEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTK 1318
K + + LE + + ++ +L E++ ++ ++E + E+E+LT++ + K
Sbjct: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQK-----KEIEILTQKLSAK 934
Query: 1319 -DSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLA 1377
DS + E E N+ ++ E++K KE +T+K+ L + +LK+ + T
Sbjct: 935 EDSIHILNEEYETKFKNQ--EKKMEKVKQKAKEMQ--ETLKKKLLDQEAKLKKELENTAL 990
Query: 1378 KIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEM 1437
++ SQ +++ + M E + +S+ A+ R+E + L E H
Sbjct: 991 EL--SQKEKQFNAKMLEMAQANSAGISD---------AVSRLETNQKEQIESLTEVHRRE 1039
Query: 1438 ---------KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE 1488
K + ++ ++LQ + E+ E +Q +K+ + +EE+ LKE
Sbjct: 1040 LNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKE 1099
Query: 1489 ----QEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
Q+ T+NEL+ L +K ++++ + KL+ ++++ E + ++K+ + +Q
Sbjct: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQD----ETKLKAHLEKL-EVDLNKSLKENTFLQ 1154
Query: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKE-EMKRVQEALQ 1603
E++ ELK E K K S L S E L+ S E+ +++K E K++ E L
Sbjct: 1155 EQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA 1214
Query: 1604 IERDQLKENTKEIV-AKMKE----SQEKEYQFL--------KMTAVNETQE-KMCEIEHL 1649
I+ D + T+ ++ AK E S K L + T V E K C + L
Sbjct: 1215 IQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSEL 1274
Query: 1650 KEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENL 1709
+ Q E T NI Q H+ E+ + + D+ E+L E++ L++
Sbjct: 1275 EAQLRQLT---EEQNTLNISFQQATHQLEEKENQIKSMKADI----ESLVTEKEALQKEG 1327
Query: 1710 RETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQD 1769
EK+ + + L E+ + ++ + EK EIS++ K L D
Sbjct: 1328 GNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT---------D 1378
Query: 1770 LKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANE 1829
L +Q + I+ +SEK +S+++K + +L +++Q+L
Sbjct: 1379 LNVQLQNSIS-----------------LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKV 1421
Query: 1830 HQL----ITLKKDVNETQKKVSEMEQ-LKKQIKDQSLTLSKLEIENLNLAQKLHENLEEM 1884
L I+ + V++ K SE ++ + + T+ +L+I+ +++ +E E++
Sbjct: 1422 DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI 1481
Query: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR 1944
+ +E D + + LK E + K + E K +LE + + +TAR++ +L
Sbjct: 1482 NLLKEELDQQNKRFDCLKGEMEDDKSKM-EKKESNLETELKSQTARIM---------ELE 1531
Query: 1945 EKISEKTIQI---SDIQKDLDKSKD----ELQKKIQELQK----KELQLLRVKEDV---- 1989
+ I++KTI+I +++ K+ ++ KD EL +K+Q Q+ K+ ++ +E +
Sbjct: 1532 DHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLE 1591
Query: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHES----LEEIRIVAKER---- 2041
N + E+E KK+ E NLS++S + L +L L E++ A+++
Sbjct: 1592 NQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAI 1651
Query: 2042 -----DELRRIKESLKMERDQFIATLREMIA-RDRQNHQVKPEKRLLSDGQQHLTESLRE 2095
++ +E K + ++ L + R+R+ H ++ + + + Q +E+L
Sbjct: 1652 KKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQ---SETLIV 1708
Query: 2096 KCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKL 2155
S E D C+ + EK Q+ L+ + K LQ EK
Sbjct: 1709 PRSAKNVAAYTEQEEADSQGCVQKTYE--EKISVLQRNLTEKEKL------LQRVGQEKE 1760
Query: 2156 FTANQRCSM--EFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQ 2213
T + M ++ + KL++ + K+ + +S+ + ++E K+ L++ Q
Sbjct: 1761 ETVSSHFEMRCQYQERLIKLEHA-----EAKQHEDQSMIGHLQEELEEKNKKYSLIVA-Q 1814
Query: 2214 HLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFP------SIKTEFQQVLSNRKE 2267
H++++ +++ QN++ +++ K E E IK E L +KE
Sbjct: 1815 HVEKEGGK-----NNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIK-ELDSCLVRQKE 1868
Query: 2268 MTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKE 2327
+ + E L +++ EKL+ +Q+ + R N+ ++ E+TE + +S + +
Sbjct: 1869 VHRVEMEELTSKY--EKLQ-ALQQMDGR---------NKPTELLEENTEEKSKSHLVQPK 1916
Query: 2328 WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELE 2387
++++ + N+ FK + G ++ +D + L E +ELE
Sbjct: 1917 LLSNMEA--QHNDLEFKLAGAEREKQKLGKEIVRLQKDLR---------MLRKEHQQELE 1965
Query: 2388 NSLHEAKESAMHKESKIIKMQKELEVTND-----IIAKLQAKVHESNKCLEKT-KETIQV 2441
KE +E KI + Q++LE+ ++ ++ + ++ + + LE T KETI
Sbjct: 1966 IL---KKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022
Query: 2442 LQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRE 2501
Q+ A + ++EE L K+ + D + + AK +E+ + A + + + ++ E
Sbjct: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLE 2082
Query: 2502 NLRRSQQ 2508
L++ Q
Sbjct: 2083 ELQKKYQ 2089
Score = 271 bits (693), Expect = 6e-72
Identities = 443/2107 (21%), Positives = 887/2107 (42%), Gaps = 347/2107 (16%)
Query: 338 VSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENL 397
V E LLKR ++ I K+Q L EK+ LQ+ +E+++ L
Sbjct: 288 VKRQENLLKRCKETIQS-----------------HKEQCTLLTSEKEALQEQLDERLQEL 330
Query: 398 TRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINL 457
K+K+ + A++ + T + + + NL
Sbjct: 331 -------------------------------EKIKDLHMAEKTKLITQL-----RDAKNL 354
Query: 458 LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQL 517
+ ++++ + V + T + E E E E+ LR+ + E+L
Sbjct: 355 IEQLEQ---DKGMVIAETKRQMHE----------TLEMKEEEIAQLRSRIKQMTTQGEEL 401
Query: 518 RTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENEL 577
R +KE+ E E +L++ + +KT++ + +K + K +E L+ EL
Sbjct: 402 REQKEKSERAAFE--ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQEL 459
Query: 578 SS-KVELL----REKEDQIKKLQEYIDSQKLENIKMDLSYSLESIED--PKQMKQTLFDA 630
S K E++ + E+QI KLQ+ + ++L + +L+ L++ E +QMK L +
Sbjct: 460 SRVKQEVVDVMKKSSEEQIAKLQK-LHEKELARKEQELTKKLQTREREFQEQMKVALEKS 518
Query: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690
++ L +E + E+L L+E + + EN ++ Q + E + ++LE L
Sbjct: 519 QSEYLKISQEKE--QQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSL 576
Query: 691 QSAFNEITKLTSLIDGKVPKDLLCNLELE----GKITDLQKELNKEVEENEALREEVILL 746
+ + E + KDL +LE E K + E +K E+ +++ +
Sbjct: 577 EKSLQE--------NKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
Query: 747 SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIG-KTKDDL 805
+L+ L + + +++++K E+ EK+ L + KE Q +EE+ KT + L
Sbjct: 629 EKLQVLKQQYQTEMEKLREKCEQ------EKETLLKD---KEIIFQAHIEEMNEKTLEKL 679
Query: 806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKE-----AQKFDSS 860
Q+ +S E E++ ++ ++ ++M QE+ E Q+ DS
Sbjct: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739
Query: 861 L-----------GALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVERE 909
+ ALK +++ L+E+ + ++E +E L+ ++ + LQ +
Sbjct: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
Query: 910 KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNA 969
+ T E+ K ++ L+Q L+ ER L + + + Q ++
Sbjct: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV-------AEVEAQKKDV 852
Query: 970 LESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL 1029
L H+ + L ++ ++ N ME+ ++ K+ +K+Q+ QT
Sbjct: 853 CTELDAHKIQVQDLMQQLEKQ---NSEMEQKVKSLTQVYESKLEDGNKEQE------QTK 903
Query: 1030 TADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRL 1089
V+ +I Q R+ +K E++ + + + A+++ + L E E +NQE
Sbjct: 904 QILVEKENMILQMRE-----GQKKEIEILTQKLSAKEDSIHI-LNEEYETKFKNQE---- 953
Query: 1090 LGDELKKQQEI--VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ 1147
KK +++ A+E +KK + D+ A+++++L+ + +L +K++Q
Sbjct: 954 -----KKMEKVKQKAKEMQETLKK-----KLLDQEAKLKKELENTALELSQKEKQFNAKM 1003
Query: 1148 EEMSEMQKKINEIENLKNELKNKELTLEHMETERLEL-------AQKLNENYEEVKSI-- 1198
EM++ + E KE E R EL +KLN+ EE++ I
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE 1063
Query: 1199 ----TKERKVLKELQK--SFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252
KE++V + QK F E++ + I ++ G+ + T++
Sbjct: 1064 IQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGV--------------KQDTTLN 1109
Query: 1253 ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLT 1312
EL+ + +K+A + L + TKL+ + L E +L ++KE + QE + EL++L
Sbjct: 1110 ELQEQLKQKSAHV---NSLAQDETKLKAHLEKL--EVDLNKSLKENTFLQEQLVELKMLA 1164
Query: 1313 EQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEV-------KH 1365
E+ K S ++++ ++ KSL + K + E L + K
Sbjct: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT 1224
Query: 1366 DQLKEHIRETLAKIQESQSK---------QEQSLNMKEKDNETTKIVSEME-QFKPKDSA 1415
+ L E L I S++ Q ++ +KE T VSE+E Q +
Sbjct: 1225 EALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
Query: 1416 LLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSE--SDQLKENIKEIVAKHL 1473
+ I + +L+E +++KS+ + + L +E LQ E + Q + KE L
Sbjct: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
Query: 1474 ETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEE 1533
+ E L E + ++ L EK+ EIS++ KQL +N +LQN I
Sbjct: 1345 KKE---------LSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-------- 1387
Query: 1534 QFNIKQISEVQEKVNEL-KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI-KE 1591
+SE + ++ L KQ+ E + +Q + K+ L+ + E++ K
Sbjct: 1388 -----SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Query: 1592 KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKE 1651
E K+ Q ++ +KE ++ K KE+ EK+ Q + + Q K + LK
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNK--RFDCLKG 1500
Query: 1652 QFETQKLNLE----NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707
+ E K +E N+ETE T + E LE+ +T++ ++ S+ E LK Q
Sbjct: 1501 EMEDDKSKMEKKESNLETELKSQTARIME-LED--HITQKTIEIESLNEVLKNYNQQKDI 1557
Query: 1708 NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKA 1767
+E + + QE + +KE +E I L V E+ +K+LEH N ++K+
Sbjct: 1558 EHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617
Query: 1768 QD---------LKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL 1818
++ L+ + ++A + K +Q+ + ++S+ +K +K E+ ++L
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
Query: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH 1878
K+QE + H L K V +Q SE + + K+ + + E ++ QK +
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQ---SETLIVPRSAKNVAAYTEQEEADSQGCVQKTY 1734
Query: 1879 ENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKE 1938
EE SV++ NL E+ L+ ++ + +ET + E++ + + R++ EH E
Sbjct: 1735 ---EEKISVLQR--NLTEKEKLLQ----RVGQEKEETVSSHFEMRCQYQ-ERLIKLEHAE 1784
Query: 1939 TVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE 1998
K E I +Q++L +E KK + + ++ K ++ N
Sbjct: 1785 A------KQHEDQSMIGHLQEEL----EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENV 1834
Query: 1999 MEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQF 2058
+ ++K + + L+ Q L + ++E+ + E+ R++ + +
Sbjct: 1835 FDDVQKTLQEKELTCQI-----------LEQKIKELDSCLVRQKEVHRVEMEELTSKYEK 1883
Query: 2059 IATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLN 2118
+ L++M R++ LL + + ++S + + + ++++++
Sbjct: 1884 LQALQQMDGRNKPT-------ELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE 1936
Query: 2119 RLSLDLEKEI-EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVL 2177
R L KEI QK+L M L+ +H ++L I+KK +Y
Sbjct: 1937 REKQKLGKEIVRLQKDLRM----------LRKEHQQEL------------EILKK-EYDQ 1973
Query: 2178 SYVTKIKEEQHE-------SINKFEMDFIDEV-EKQKELLIKIQHLQQDCDVPSRELRDL 2229
KIK+EQ + ++ + +F ++ +K++EL + I+ EL
Sbjct: 1974 EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAEL--- 2030
Query: 2230 KLNQNMDLHIEE---ILKDFSESEFPSIKT--EFQQVLSNRKEMTQFLEEWLNTRFDIEK 2284
++ H EE +LK +E + +T ++++L R+E L T+ +E+
Sbjct: 2031 -----LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQ--LEE 2083
Query: 2285 LKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATIS------KEWEQDLKSLKEK 2338
L+ +K ++ Q N N+ + IM T+ +++ IS +E+ + + +L+++
Sbjct: 2084 LQ---KKYQQKLEQEENPGNDN-VTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDR 2139
Query: 2339 NEKLFKN 2345
+K KN
Sbjct: 2140 LKKYEKN 2146
Score = 249 bits (637), Expect = 2e-65
Identities = 396/1770 (22%), Positives = 761/1770 (42%), Gaps = 292/1770 (16%)
Query: 305 ICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVS- 363
I TI S +E ++ Q S K + V + S++E + K + +L ++ +E++
Sbjct: 441 IKTIEKTSEEERISLQQELSRVK--QEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTK 498
Query: 364 -LETRAQ--------AMEKDQ--LAQLLEEKDLLQKVQNEKIENLTRMLVTSSS---LTL 409
L+TR + A+EK Q ++ +EK+ + + E++E + ++T S L
Sbjct: 499 KLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDL 558
Query: 410 QQELKAKRKRRVTWCLGKINK--MKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCS 467
QQE + R R + + K +N N + + H I ++ E ++
Sbjct: 559 QQEAETYRTR-ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT--- 614
Query: 468 ESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRA----DYDNLVLDYEQL-RTEKE 522
E + + D L W ++L Q+ ++E+ LR + + L+ D E + + E
Sbjct: 615 ELESLKHQQDAL----WTEKLQVLKQQ-YQTEMEKLREKCEQEKETLLKDKEIIFQAHIE 669
Query: 523 EMELKLKEKNDLDEFE----------ALERKTKKDQEMQLI------------------- 553
EM K EK D+ + E L+ + K ++E+ ++
Sbjct: 670 EMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK 729
Query: 554 -HEISNLKNLVKHAEVYNQDLENELSSKVE----LLREKEDQIKKLQEYIDSQKLE---- 604
H + +++K EV Q E L ++ LL+E++ +K+ Q ++++ + +
Sbjct: 730 NHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRS 789
Query: 605 -------NIKMDLSYSLESI---------EDPKQMKQTLFDAET-----------VALDA 637
+ K+D+ S +S E Q++Q L D ET V
Sbjct: 790 EGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQK 849
Query: 638 KRESAFLRSENLELKEKMKELATTYKQMENDI----QLYQSQLEAKKK-----MQVDLEK 688
K L + +++++ M++L +ME + Q+Y+S+LE K Q+ +EK
Sbjct: 850 KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909
Query: 689 E------LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNK---------EV 733
E + EI LT + K + N E E K + +K++ K E
Sbjct: 910 ENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQET 969
Query: 734 EENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSE--KDKLFSEVVHKESRV 791
+ + L +E L EL++ E+ + K+ K E+ S D + +++ ++
Sbjct: 970 LKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQI 1029
Query: 792 QGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLH-MDFEQKYKMVLE----------EN 840
+ L E + +D+ + K +Q+ + + +H + ++K + V E E
Sbjct: 1030 ESLTEVHRRELNDVISIWE--KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEK 1087
Query: 841 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQEL----QEKTR----------EVQERL 886
E MN+EI L +E K D++L L+ +L K+ + Q++T+ ++ + L
Sbjct: 1088 EEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
Query: 887 NEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERD 946
E L+EQL + +R+ + +T KL+ T EE ++L + + E +E
Sbjct: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207
Query: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKD 1006
+L ++ +++ E L A + E IN SK + +SR H + T + K+
Sbjct: 1208 KLSEELAIQLDICCKKTEALLEA-----KTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
Query: 1007 EFQQKMVGIDK-----KQDLEAKNTQTLT-------ADVKDNEIIEQQRKIFSLIQEKNE 1054
K + + +Q E +NT ++ + K+N+I + I SL+ EK
Sbjct: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
Query: 1055 LQQM---LESVIAEKE----QLKTDLKENIEMTIENQEELRLLGDEL----KKQQEIVAQ 1103
LQ+ + +EKE QLK +L ENI +EEL+ E+ K+ ++ Q
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 1104 EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL 1163
+N E E + + R EEK E Q+Q+ ++ + +E +++++ N
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDEEKC-ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK 1441
Query: 1164 KNELKNKELT--LEHMETER---LELAQKLNENYEEVKSITKERKVLKELQKSFETERDH 1218
+E K K + +H T + ++L K E YE+ + I ++ L + K F D
Sbjct: 1442 FSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRF----DC 1497
Query: 1219 LRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKL 1278
L+G E+E + +++ LK I EL +++KT +I + ++ K++ +
Sbjct: 1498 LKG---EMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ- 1553
Query: 1279 QEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQ 1338
Q++I E +EL V+++ QE E + +++ K T ++ + L K +
Sbjct: 1554 QKDI----EHKEL---VQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
Query: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398
E + S+ + + LK +++ LE E+ AK+ E + K EQ + +K
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLE----------SESAAKLAELKRKAEQKIAAIKK--- 1653
Query: 1399 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSES 1458
+++S+ME+ ++ E + L+ +LQE E+ + ++ + E QSE+
Sbjct: 1654 --QLLSQMEE--KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSV----ESSQSET 1705
Query: 1459 DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTI-QKQLEAI 1517
+ + K + A +EE C K EE I+ L+ NL+EKE + + Q++ E +
Sbjct: 1706 LIVPRSAKNVAA--YTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETV 1763
Query: 1518 NDKLQNKIQ-----------EIYEKEEQFNIKQISEVQEKVNELKQF-------KEHRKA 1559
+ + + Q E + E+Q I + E E+ N+ KE K
Sbjct: 1764 SSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKN 1823
Query: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK----RVQEALQIERDQLKENTKE 1615
A Q++E+ ++ LQE + QI+ ++ +E+ R +E ++E ++L ++
Sbjct: 1824 NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEK 1883
Query: 1616 IVAKMK-------------ESQEKEYQFL---KMTAVNETQEKMCEIEHLKEQFETQKLN 1659
+ A + ++EK L K+ + E Q E + + E QKL
Sbjct: 1884 LQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943
Query: 1660 LENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQL--------KENLRE 1711
E + + L + E+ +E+ + KE D R EE +K E++ L K+ +RE
Sbjct: 1944 KEIVRLQK-DLRMLRKEHQQELEILKKEYDQER--EEKIKQEQEDLELKHNSTLKQLMRE 2000
Query: 1712 TITRDLEKQEELKIVHMH------------LKEHQETIDKLRGIVSEKTNEISNMQKDLE 1759
T+ +K++EL++ L+ HQE ++L ++EK +++ K E
Sbjct: 2001 FNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYE 2060
Query: 1760 HSNDA------LKAQDLKIQ-EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLE 1812
DA K +DL+ Q EEL+ + EQ+E + E +L+ +
Sbjct: 2061 EILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLIS 2120
Query: 1813 NSNAKLQEKIQELKANEHQLITLKKDVNET 1842
+S K QE +++ E +L +K+V T
Sbjct: 2121 DSKLKEQEFREQIHNLEDRLKKYEKNVYAT 2150
Score = 232 bits (591), Expect = 4e-60
Identities = 384/1920 (20%), Positives = 848/1920 (44%), Gaps = 226/1920 (11%)
Query: 727 KELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKD-------- 778
K+L +++ E + ++ + ++ S S R+R +E+L T ++
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
Query: 779 -KLFSEVVHKESRVQGLLEEI---GKTKDDLATTQS----NYKSTDQEFQNFKTLHMDFE 830
KL V ES + ++E +K+ L T S N D +F D +
Sbjct: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDP-PSDMD 121
Query: 831 QKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK---TELSYKTQELQEKTREVQERLN 887
+ + ++ ++ +N+E L + ++ + SL + + +EL Q LQ + +++Q L+
Sbjct: 122 SEAEDLVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILS 179
Query: 888 EMEQ--LKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDD-LKQLQESLQIE 944
+ + L+ E R+ LQ ++ K + E+ +LEE KD + LQ + +
Sbjct: 180 QSQDKSLRRIAELREE-LQMDQQAKKHLQEEFDASLEE-------KDQYISVLQTQVSLL 231
Query: 945 RDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTG-E 1003
+ +L++ MN+D L+ L Q + + + E +E+ T +
Sbjct: 232 KQRLRNG-----PMNVDV-------LKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK 279
Query: 1004 TKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS--LIQEKNELQQMLES 1061
T + QQ+ + ++++L + +T+ + + ++ +++ L + EL+++ +
Sbjct: 280 TLETLQQR---VKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDL 336
Query: 1062 VIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDR 1121
+AEK +L T L++ + + +++ ++ E K+Q + KE E+++ R
Sbjct: 337 HMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLE------MKEEEIAQLRSR 390
Query: 1122 LAEVEEKLKEKSQQLQEKQQQLLN-VQEEMSEMQKKINEIENLKNELKNKELTLEHM-ET 1179
+ ++ + +E +Q ++ ++ +++ +S QK LK E+ + T+E E
Sbjct: 391 IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE 450
Query: 1180 ERLELAQKLNENYEEVKSITKE--RKVLKELQKSFETERDHLRGYI-REIEATGLQTKEE 1236
ER+ L Q+L+ +EV + K+ + + +LQK E E + ++++ + +E+
Sbjct: 451 ERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQ 510
Query: 1237 LKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVK 1296
+K+A L++ Q ++ + ++ + + +L+K +L E + L +++
Sbjct: 511 MKVA---LEKSQSEYLKISQEKEQQESLALEELELQKK--------AILTESENKLRDLQ 559
Query: 1297 EVSETQETM-----NELELLTEQSTTKDSTTLARIEMERLRLNEKF----QESQEEIKSL 1347
+ +ET T + LE +++ + +E E+ + N++ ++ + E++SL
Sbjct: 560 QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESL 619
Query: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEME 1407
++D L T E L+V LK+ + + K++E +++++L +K+K+ + EM
Sbjct: 620 KHQQDALWT--EKLQV----LKQQYQTEMEKLREKCEQEKETL-LKDKEIIFQAHIEEMN 672
Query: 1408 QFKPKDSALLRIEIEMLG--LSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI 1465
+ + + + E+E L LS+ L+ H + ++ KD ++++ L+++ D+ K +
Sbjct: 673 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 732
Query: 1466 KEIVAKHL-ETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNK 1524
++ V + E E ++ LK+Q IN+L + L E++ + Q +E + ++
Sbjct: 733 QQQVDSIIKEHEVSIQRTEKALKDQ---INQLELLLKERDKHLKEHQAHVENLEADIK-- 787
Query: 1525 IQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEE 1584
+ E+Q+ +L F+ ++ A ++ E ++ +L +L + + E
Sbjct: 788 -------------RSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE 834
Query: 1585 IQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM-KESQEKEYQFLKMTAVNETQEKM 1643
++ K+ E++ ++ + E D K ++++ ++ K++ E E + +T V E++ +
Sbjct: 835 RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE- 893
Query: 1644 CEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERD 1703
+ KEQ +T+++ +E EN+ L +MR K+ ++ + + L + D
Sbjct: 894 ---DGNKEQEQTKQIL---VEKENMIL---------QMREGQKK--EIEILTQKLSAKED 936
Query: 1704 QLKENLRETITRDLEKQEELKIVHMHLKEHQETIDK-LRGIVSEKTNEISNMQKDLEHSN 1762
+ E T+ ++++++ V KE QET+ K L ++ E+ N +L
Sbjct: 937 SIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKE 996
Query: 1763 DALKAQDLK--------IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814
A+ L+ I + + + KEQ E++ ++ E D +S +K L
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR--RELNDVISIWEKKLNQQ 1054
Query: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKV----SEMEQLKKQIKDQSLTLSKLEIEN 1870
+LQE +E QL +++V E ++K+ E E++ K+I + L+ E
Sbjct: 1055 AEELQE------IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI-------TWLKEEG 1101
Query: 1871 LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTAR 1930
+ L+E E++K ++L + E LK ++L+ L ++ + +Q++L +
Sbjct: 1102 VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELK 1161
Query: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVN 1990
ML++E K V +L K+ + ++ +KS L+ K E +K +L ++
Sbjct: 1162 MLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL---AIQLD 1218
Query: 1991 MSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKES 2050
+ KK + + K E N+S +++ H + ++KE+
Sbjct: 1219 ICCKKTEALLEAKTN-ELINISSSKTNAILSRISHCQHRT--------------TKVKEA 1263
Query: 2051 LKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEM 2110
L ++ T+ E+ + Q Q+ E+ L+ Q T L EK ++IK + +
Sbjct: 1264 LLIK----TCTVSEL---EAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESL 1316
Query: 2111 DDHYECL-----NRLSLDLEKE---IEFQKELSMRVKA-NLSLPYLQTKHIEKLFTANQR 2161
E L N+ EKE + +KELS + A L L+ K +E + Q
Sbjct: 1317 VTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQL 1376
Query: 2162 CSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDV 2221
+ +L+ +S E+ +I+ + +E + ELL ++Q L D
Sbjct: 1377 TDLNV-----QLQNSISL-----SEKEAAISSLRKQYDEE---KCELLDQVQDLSFKVDT 1423
Query: 2222 PSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFD 2281
S+E + L Q +++ FSE + ++ F Q + KE+ LE ++
Sbjct: 1424 LSKE-KISALEQ-----VDDWSNKFSEWK-KKAQSRFTQHQNTVKELQIQLELKSKEAYE 1476
Query: 2282 IEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEK 2341
++ N +++E D Q N F+ + ++ ++ E++ + + E + + E +
Sbjct: 1477 KDEQINLLKEELD---QQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDH 1533
Query: 2342 LFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKE 2401
+ +T++ + N Q + + Q E E +N + EA+E + E
Sbjct: 1534 I--TQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLE 1591
Query: 2402 SKIIKMQKELEVTNDIIAKLQAKV---HESNKCLEKTKETIQVLQDKVALGAKPYKEEIE 2458
+++ M+ ELE + + V E K LE E+ K+A + +++I
Sbjct: 1592 NQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAA--KLAELKRKAEQKIA 1649
Query: 2459 DLKMKLVKIDLEKMKNAKE-FEKEISATKATVEYQKEVIRLLRENLRRSQQAQ-DTSVIS 2516
+K +L+ EK + K+ E +S ++ ++ + +L E L+ + +Q +T ++
Sbjct: 1650 AIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVP 1709
Query: 2517 EHTDPQPSNKPLTCGGGSGIVQNT---KALILKSEHIRLEKEISKLKQQNEQLIKQKNEL 2573
+ G VQ T K +L+ EK + ++ Q+ E+ + E+
Sbjct: 1710 RSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEM 1769
Score = 107 bits (267), Expect = 2e-22
Identities = 193/964 (20%), Positives = 390/964 (40%), Gaps = 121/964 (12%)
Query: 272 LSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKYMKN 331
L + + IN SK IL +T + +T T + + + +
Sbjct: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTT---KVKEALLIKTCTVSELEAQLRQLTE 1283
Query: 332 TPYVNEVSTDEAL--LKRYRKEIMDLKKQLEEVSLETRAQAMEKD---QLAQLLEEKDLL 386
+S +A L+ +I +K +E SL T +A++K+ Q E++ +
Sbjct: 1284 EQNTLNISFQQATHQLEEKENQIKSMKADIE--SLVTEKEALQKEGGNQQQAASEKESCI 1341
Query: 387 QKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNI 446
+++ E EN+ + + +++ELK K+ +I+ + + +I
Sbjct: 1342 TQLKKELSENINAVTL------MKEELKEKKV--------EISSLSKQLTDLNVQLQNSI 1387
Query: 447 TTKTHKLSINLLR-EIDESVCSESDV---FSNTLDTLSEIEWNPATKLLNQENIESELNS 502
+ + +I+ LR + DE C D S +DTLS+ + + ++ + N SE
Sbjct: 1388 SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK- 1446
Query: 503 LRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNL 562
+ ++ + ++ELK KE + DE L ++ Q + +++
Sbjct: 1447 -KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 563 VKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQ 622
E +LE EL S+ + E ED I Q+ I+ + L + + Y+ + + K+
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHIT--QKTIEIESLNEVLKN--YNQQKDIEHKE 1561
Query: 623 MKQTLFDAETVALDA-----KRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLE 677
+ Q L + + + + E L EN ++ EL T K++E+ +S+ E
Sbjct: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLEN-QVYSMKAELETKKKELEHVNLSVKSKEE 1620
Query: 678 AKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLE------LEGKITDLQKELNK 731
K ++ LE E + E+ + + K LL +E +G + L ELN
Sbjct: 1621 ELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLS-ELNT 1679
Query: 732 EVEENEALREEVILLSELKSLPSE------VERLRKEI-----QDKSEELHIITSEKDKL 780
+++E E RE IL +LKS+ S V R K + Q++++ + ++
Sbjct: 1680 KLQERE--REVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737
Query: 781 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQ--------- 831
S + + + LL+ +G+ K++ ++ + QE + K H + +Q
Sbjct: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE-RLIKLEHAEAKQHEDQSMIGH 1796
Query: 832 ----------KYKMVLEE---------NERMNQEIVNLSKEAQKFDSSLGALKTELSYKT 872
KY +++ + N + Q + N+ + QK L K
Sbjct: 1797 LQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856
Query: 873 QELQE-KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE-------- 923
+EL R+ + EME+L + E + Q R K TE L++ EE
Sbjct: 1857 KELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKP--TELLEENTEEKSKSHLVQ 1914
Query: 924 ---VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI 980
+ + + +DL+ + E+ +L +I + Q+ LR K+HQ+ +
Sbjct: 1915 PKLLSNMEAQHNDLEFKLAGAEREKQKLGKEI-------VRLQKDLRMLR---KEHQQEL 1964
Query: 981 NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIE 1040
LK + +E + E+ E K K + + L A+ Q L +K+
Sbjct: 1965 EILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQL-AQKEQELEMTIKETINKA 2023
Query: 1041 QQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI 1100
Q+ + L + E Q+L+ + + + LK K E+ +EE+ +L+ Q E
Sbjct: 2024 QEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEE 2083
Query: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL-------QEKQQQLLNVQEEMSEM 1153
+ ++ +++E + E++ +L +K+ + QE ++Q+ N+++ + +
Sbjct: 2084 LQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKY 2143
Query: 1154 QKKI 1157
+K +
Sbjct: 2144 EKNV 2147
>gi|4758648 kinesin family member 5B [Homo sapiens]
Length = 963
Score = 294 bits (752), Expect = 9e-79
Identities = 271/982 (27%), Positives = 457/982 (46%), Gaps = 120/982 (12%)
Query: 7 VAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEEI 66
+ V R RPLN E + G+ ++ ++ V+ SK + FDRVF + + + VY +
Sbjct: 9 IKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVI---ASKPYAFDRVFQSSTSQEQVYNDC 65
Query: 67 AAPIIDSAIQGYNGTIFAYGQTASGKTYTMMG---SEDHLGVIPRAIHDIFQKIKKFPDR 123
A I+ ++GYNGTIFAYGQT+SGKT+TM G + +G+IPR + DIF I +
Sbjct: 66 AKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDEN 125
Query: 124 -EFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALKWI 182
EF ++VSY EIY + I DLL L + ED NR YV TE V + + + I
Sbjct: 126 LEFHIKVSYFEIYLDKIRDLL--DVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTI 183
Query: 183 TKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERA 242
+G+ +RH T MN+ SSRSH+IF + ++ G L LVDLAGSE+
Sbjct: 184 DEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGK-----LYLVDLAGSEKV 238
Query: 243 AQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKT 302
++TGA G L E NIN+SL LG VI L++G ++ YRDSK+TRILQ+SLGGN +T
Sbjct: 239 SKTGAEGAVLDEAKNINKSLSALGNVISALAEGST--YVPYRDSKMTRILQDSLGGNCRT 296
Query: 303 RIICTITPVSFD--ETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE 360
I+ +P S++ ET + L F AK +KNT VN T E K+Y KE
Sbjct: 297 TIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKE--------- 347
Query: 361 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR 420
+EK+ + + + +EN ++ + ++ ++
Sbjct: 348 --------------------KEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANL 387
Query: 421 VTWCLGKINKMKNSNYADQFNIPTNIT----TKTHKLSINLLREIDESVCSESDVFSNTL 476
+ + K + N A + N T K + L +++D+ +
Sbjct: 388 EAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDK--------DEEI 439
Query: 477 DTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDE 536
+ S++ T++L+QE + L S R D DN+ + +L+ E + + ++KE
Sbjct: 440 NQQSQLVEKLKTQMLDQEEL---LASTRRDQDNMQAELNRLQAENDASKEEVKE-----V 491
Query: 537 FEALER-KTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQ 595
+ALE DQ+ Q + + + L L +EL+ K L + +++KL+
Sbjct: 492 LQALEELAVNYDQKSQEVEDKTKEYEL----------LSDELNQKSATLASIDAELQKLK 541
Query: 596 EYIDSQKLENIKMDLSYSLESIE--------DPKQMKQT-LFDAETVALDAKRESAFLRS 646
E + QK +M S + E D KQ + T + D E A+ + ++S
Sbjct: 542 EMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTV--ARLYISKMKS 599
Query: 647 ENLELKEKMKELATTY----KQMEND------IQLYQSQLEAKKKMQVDLEKELQSAFNE 696
E + ++ K+L +T K+ME + QL SQ EAK K L + LQ+ +
Sbjct: 600 EVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIK---SLTEYLQNVEQK 656
Query: 697 ITKLTSLIDGKVPKDLLCNLELEGKITDLQKE-LNKEVEENEALRE-EVILLSELKSLPS 754
+L +D + L L + K+ +++KE LNK NE + E + S ++
Sbjct: 657 KRQLEESVDAL--SEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQK 714
Query: 755 EVERLRKEIQDKSEELHIITSEKDKLFSEVVH---KESRVQGLLEEIGKTKDDLATTQSN 811
++ LR E++ K++ + + + K+ E + +++ +E + +L Q
Sbjct: 715 QISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDR 774
Query: 812 YKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS----SLGALKTE 867
+Q Q+ K L ++ + + + Q++ K++ + DS A K +
Sbjct: 775 ---REQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQK 831
Query: 868 LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQ-TVEREKTL---ITEKLQQTLEE 923
+S+ L++ T+ ++ + + L+ +L + L+ T ER K L + E + +
Sbjct: 832 ISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRD 891
Query: 924 VKTLTQEKDDLKQLQESLQIER 945
K QE D +K+ S + R
Sbjct: 892 RKRYQQEVDRIKEAVRSKNMAR 913
Score = 90.5 bits (223), Expect = 2e-17
Identities = 154/802 (19%), Positives = 326/802 (40%), Gaps = 80/802 (9%)
Query: 444 TNITTKTHKLSINLLREIDES-VCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNS 502
TN++ K + ++ E VCS +V +DT+ E + N + N S +S
Sbjct: 151 TNLSVHEDKNRVPYVKGCTERFVCSPDEV----MDTIDEGKSNRHVAVTNMNEHSSRSHS 206
Query: 503 LRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNL-KN 561
+ +++ +Q T+ E+ KL K L + E+ +K E ++ E N+ K+
Sbjct: 207 I------FLINVKQENTQTEQ---KLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKS 257
Query: 562 LVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPK 621
L V + E S+ V K +I LQ+ + I + S S + + K
Sbjct: 258 LSALGNVISALAEG--STYVPYRDSKMTRI--LQDSLGGNCRTTIVICCSPSSYNESETK 313
Query: 622 ------QMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQ 675
Q +T+ TV ++ + + + + + KEK K L T + +EN++ +++
Sbjct: 314 STLLFGQRAKTI--KNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNG 371
Query: 676 LEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDL------------LCNLE---LEG 720
Q D EK AF + K +L + K + C E L
Sbjct: 372 ETVPIDEQFDKEKANLEAFT-VDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYK 430
Query: 721 KITDLQKELNKEVEENEALREEVILLSEL--------KSLPSEVERLRKEIQDKSEELHI 772
++ D +E+N++ + E L+ +++ EL ++ +E+ RL+ E EE+
Sbjct: 431 QLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKE 490
Query: 773 ITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQK 832
+ ++L K V+ +E D+L + S D E Q K + +++
Sbjct: 491 VLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKR 550
Query: 833 YKMVLEENERMNQEI-VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQ 891
++ + EI + + K G + E + + + EV+ + +Q
Sbjct: 551 AAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQ 610
Query: 892 LKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSD 951
L+ + ++ E+E ++ Q ++K+LT+ +++Q + L+ D L +
Sbjct: 611 LESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEE 670
Query: 952 IHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVS--RNLHMEENTGETKDEFQ 1009
+ + + QE++ + +T N +K + +++ R H ++ +DE +
Sbjct: 671 L-----VQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETH-QKQISSLRDEVE 724
Query: 1010 QKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQL 1069
K I QD K ++ + + K+ + QEK+ L + +EQ
Sbjct: 725 AKAKLITDLQDQNQKMM------LEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQA 778
Query: 1070 KTDLK---ENIEMTIENQEELRL-----LGDELKKQQEIVAQEKNHAIKKEGELSRTCDR 1121
+ DLK E + ++ LR L +KK EI + + + ++ ++S +
Sbjct: 779 RQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENN 838
Query: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETER 1181
L ++ + K+ + + + +L +++ + +++ +E+ E K E+ +R
Sbjct: 839 LEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAK------ENASRDR 892
Query: 1182 LELAQKLNENYEEVKSITKERK 1203
Q+++ E V+S R+
Sbjct: 893 KRYQQEVDRIKEAVRSKNMARR 914
Score = 87.0 bits (214), Expect = 2e-16
Identities = 130/601 (21%), Positives = 247/601 (41%), Gaps = 82/601 (13%)
Query: 1208 LQKSFETERDHLRGYIREIEATGLQTKEELKIAHI------HLKEHQETIDELRRSVSEK 1261
+ + F+ E+ +L + + + T K I I ++ +E I +L + + +K
Sbjct: 376 IDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDK 435
Query: 1262 TAQIINTQDL-EKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS 1320
+I L EK T++ L +E+ L ++ Q +N L+ E +K+
Sbjct: 436 DEEINQQSQLVEKLKTQM------LDQEELLASTRRDQDNMQAELNRLQ--AENDASKEE 487
Query: 1321 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ 1380
+E L +N + + +E++ TKE E+ D+L + TLA I
Sbjct: 488 VKEVLQALEELAVN--YDQKSQEVEDKTKE----------YELLSDELNQK-SATLASID 534
Query: 1381 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEI------EMLGLSKRLQESH 1434
K +KE N K +EM KD A + I + + G +E
Sbjct: 535 AELQK------LKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFT 588
Query: 1435 DEMKSVAKEKDDLQRL-QEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETI 1493
++K K +++ + + Q ES Q + N K E E+EL + + E I
Sbjct: 589 VARLYISKMKSEVKTMVKRCKQLESTQTESN-----KKMEENEKELAACQLRISQHEAKI 643
Query: 1494 NELRVNLSEKETEISTIQKQLEAINDKL-----QNKIQEIYEKEEQFNIKQISEVQEKVN 1548
L L E + +++ ++A++++L Q K+ E+ EKE ++ +EV++ V
Sbjct: 644 KSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEM-EKEHLNKVQTANEVKQAVE 702
Query: 1549 ELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ 1608
+ Q + HR+ + S+ ++ + + Q++ Q M+ E+E ++ E L+ DQ
Sbjct: 703 Q--QIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLK-ATDQ 759
Query: 1609 LKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI 1668
K + M++ +E+ Q LK + ET K + H + Q L ++ I
Sbjct: 760 EKSRKLHELTVMQDRREQARQDLK--GLEETVAKELQTLHNLRKLFVQDLATRVKKSAEI 817
Query: 1669 ------------RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRD 1716
+ L NLE++ V K+ L L+ E +L++ LR T
Sbjct: 818 DSDDTGGSAAQKQKISFLENNLEQLTKVHKQ---LVRDNADLRCELPKLEKRLRAT---- 870
Query: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEEL 1776
E +K + LKE +E + R E+ +++ + N A + +I + +
Sbjct: 871 ---AERVKALESALKEAKENASRDR---KRYQQEVDRIKEAVRSKNMARRGHSAQIAKPI 924
Query: 1777 R 1777
R
Sbjct: 925 R 925
Score = 83.6 bits (205), Expect = 2e-15
Identities = 123/590 (20%), Positives = 257/590 (43%), Gaps = 66/590 (11%)
Query: 1536 NIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEM 1595
N++ +E +K E + KE K + +Q +E+++ NR + + + I E+ +
Sbjct: 332 NVELTAEQWKKKYEKE--KEKNKILRNTIQWLENEL----NRWRNGET---VPIDEQFDK 382
Query: 1596 KRVQ-EALQIERDQLKENTKEIVA-------KMKESQEKEYQFLKM-TAVNETQEKMCEI 1646
++ EA +++D N K A E ++ E + K+ +++ E++ +
Sbjct: 383 EKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQ 442
Query: 1647 EHLKEQFETQKLNLENIETENIRLTQILHENLEEMRS---VTKE--RDDLRSVEETLKVE 1701
L E+ +TQ L+ E + R + L +++ +KE ++ L+++EE L V
Sbjct: 443 SQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEE-LAVN 501
Query: 1702 RDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQ----KD 1757
DQ + + + +EL L + KL+ + + + + M KD
Sbjct: 502 YDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKD 561
Query: 1758 LEHSNDALKAQDLK-------IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKD 1810
L A+ D+K I EE +A ++ I K++ V + ++
Sbjct: 562 LAEIGIAVGNNDVKQPEGTGMIDEEFTVARLY-------ISKMKSEVKTMVKRCKQLEST 614
Query: 1811 LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN 1870
SN K++E +EL A + ++ + + + + +EQ K+Q+++ LS+ E+
Sbjct: 615 QTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSE-ELVQ 673
Query: 1871 LNLAQKLHE-NLEEMKSVMKERDNLRRVEETLKLERDQLKESLQ------ETKARDLEIQ 1923
L +K+HE E + V + + VE+ ++ R+ ++ + E KA+ +
Sbjct: 674 LRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDL 733
Query: 1924 QELKTARMLSKEH-KETVDKLREKISEKTIQISDIQKDLDKSKDELQ--KKIQELQKKEL 1980
Q+ ML +E + +KL+ EK+ ++ ++ D+ + Q K ++E KEL
Sbjct: 734 QDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKEL 793
Query: 1981 QLLR-----VKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIR 2035
Q L +D+ KK E++ A S +N + K+H+ L +R
Sbjct: 794 QTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQL--VR 851
Query: 2036 IVAKERDELRRIKESLKMERDQF------IATLREMIARDRQNHQVKPEK 2079
A R EL ++++ L+ ++ + +E +RDR+ +Q + ++
Sbjct: 852 DNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDR 901
Score = 81.6 bits (200), Expect = 9e-15
Identities = 122/630 (19%), Positives = 266/630 (42%), Gaps = 92/630 (14%)
Query: 947 QLKSDIHDTVNMNID-TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK 1005
Q I +TV +N++ T EQ + E K+ + + + E++R + E T
Sbjct: 320 QRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGE--TVPID 377
Query: 1006 DEFQQKMVGIDK---KQDLEAKNTQTLTA--------------------------DVKDN 1036
++F ++ ++ +D+ N + TA D KD
Sbjct: 378 EQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDE 437
Query: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDL----------KENIEMTIENQEE 1086
EI +Q + + L + + +++L S +++ ++ +L KE ++ ++ EE
Sbjct: 438 EINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEE 497
Query: 1087 LRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNV 1146
L + D+ K QE+ + K + + + EL++ LA ++ +L++ + ++++
Sbjct: 498 LAVNYDQ--KSQEVEDKTKEYELLSD-ELNQKSATLASIDAELQKLKEMTNHQKKR---A 551
Query: 1147 QEEMSEMQKKINEIENL--KNELKNKELTLEHMETERLELAQ-KLNENYEEVKSITKERK 1203
E M+ + K + EI N++K E T M E +A+ +++ EVK++ K K
Sbjct: 552 AEMMASLLKDLAEIGIAVGNNDVKQPEGT--GMIDEEFTVARLYISKMKSEVKTMVKRCK 609
Query: 1204 VLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQ---ETIDELRRSVSE 1260
L+ Q + + + ++EL + + +H+ +++ E ++V +
Sbjct: 610 QLESTQTESNKKME--------------ENEKELAACQLRISQHEAKIKSLTEYLQNVEQ 655
Query: 1261 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS 1320
K Q LE+S L EE+ L ++++ KE +T NE++ EQ
Sbjct: 656 KKRQ------LEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHR 709
Query: 1321 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ 1380
T + + L ++ + + I L + + +E L V+H++LK +E K+
Sbjct: 710 ET---HQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLH 766
Query: 1381 E---SQSKQEQS-LNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDE 1436
E Q ++EQ+ ++K + K + + + L ++ + K + D+
Sbjct: 767 ELTVMQDRREQARQDLKGLEETVAKELQTLHNLRK-----LFVQDLATRVKKSAEIDSDD 821
Query: 1437 MKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL 1496
A +K + L++ +QL + K++V + + EL L+ E + L
Sbjct: 822 TGGSAAQKQKI----SFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKAL 877
Query: 1497 RVNLSEKETEISTIQKQLEAINDKLQNKIQ 1526
L E + S +K+ + D+++ ++
Sbjct: 878 ESALKEAKENASRDRKRYQQEVDRIKEAVR 907
Score = 78.6 bits (192), Expect = 8e-14
Identities = 154/829 (18%), Positives = 316/829 (38%), Gaps = 162/829 (19%)
Query: 1607 DQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIE-T 1665
D+ K N V M E + + + E + EQ + KL L ++ +
Sbjct: 184 DEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQT--------EQKLSGKLYLVDLAGS 235
Query: 1666 ENIRLTQILHENLEEMRSVTKERDDLRSVEETL---------------KVERDQLKENLR 1710
E + T L+E +++ K L +V L ++ +D L N R
Sbjct: 236 EKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCR 295
Query: 1711 ETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISN-MQKDLEHSNDALKAQD 1769
TI ++ + E+ K + ++ I N + ++E + + K +
Sbjct: 296 TTI-----------VICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKY 344
Query: 1770 LKIQEELRIAHMHLKEQQETIDKLRG----IVSEKTDKLS------NMQKDLENSNAKLQ 1819
K +E+ +I ++ + +++ R + E+ DK + KD+ +N K
Sbjct: 345 EKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPA 404
Query: 1820 EKI--------QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENL 1871
I E + E ++ L K +++ +++++ QL +++K Q L +L
Sbjct: 405 TAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEEL----- 459
Query: 1872 NLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM 1931
+ S +++DN++ L+ E D KE +
Sbjct: 460 ------------LASTRRDQDNMQAELNRLQAENDASKEEV------------------- 488
Query: 1932 LSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNM 1991
KE + +++L +K+ ++ D K+ + DEL +K L + +L ++KE N
Sbjct: 489 --KEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNH 546
Query: 1992 SHKKINE-MEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI-VAKERDELRRIKE 2049
K+ E M L K +++ + + + T + E R+ ++K + E++ + +
Sbjct: 547 QKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVK 606
Query: 2050 SLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCS-RIKELLKRYS 2108
K Q +T E + +N EK L + C RI + +
Sbjct: 607 RCK----QLESTQTESNKKMEEN-----EKELAA-------------CQLRISQHEAKIK 644
Query: 2109 EMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHR 2168
+ ++ + + + LE+ ++ E ++++A + ++ +H+ K+ TAN+
Sbjct: 645 SLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANE-------- 696
Query: 2169 IMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRD 2228
V V + + E+ K DEVE + +L+ +Q
Sbjct: 697 -------VKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQ--------------- 734
Query: 2229 LKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNG 2288
NQ M L E + E +K Q+ E+T + R D++ L+
Sbjct: 735 -DQNQKMMLEQERL-----RVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEET 788
Query: 2289 IQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT 2348
+ KE + + F + + +S E + S +Q + L+ E+L K ++
Sbjct: 789 VAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQ 848
Query: 2349 LKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESA 2397
L A P + + + T E+++ LE++L EAKE+A
Sbjct: 849 LVRDNADLRCELPKLE---------KRLRATAERVKALESALKEAKENA 888
Score = 75.5 bits (184), Expect = 7e-13
Identities = 125/629 (19%), Positives = 260/629 (41%), Gaps = 111/629 (17%)
Query: 1065 EKEQLKTDLKENIEMTIENQE--ELRLLGDELKKQQEIVAQEKNHAIKK-----EGELSR 1117
E E T L TI+N + L ++ KK+ E +EKN ++ E EL+R
Sbjct: 309 ESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYE-KEKEKNKILRNTIQWLENELNR 367
Query: 1118 TCD-RLAEVEEKLKEKSQQLQ----EKQQQLLNVQEEMS----------EMQKKINEIEN 1162
+ ++E+ ++ L+ +K L N + + E +K EI
Sbjct: 368 WRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAK 427
Query: 1163 LKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGY 1222
L +L +K+ +++N+ + V+ + + +EL S ++D+++
Sbjct: 428 LYKQLDDKD--------------EEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAE 473
Query: 1223 IREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTA--QIINTQDLEKSHT--KL 1278
+ ++A +KEE+K L+E D+ + V +KT ++++ + +KS T +
Sbjct: 474 LNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASI 533
Query: 1279 QEEIPVLHE---------EQELLPNVKEVSETQETMNELELLTEQST--TKDSTTLARIE 1327
E+ L E + + +K+++E + ++ + T + T+AR+
Sbjct: 534 DAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLY 593
Query: 1328 MERLR-------------------LNEKFQESQEE--------------IKSLTKERDNL 1354
+ +++ N+K +E+++E IKSLT+ N+
Sbjct: 594 ISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNV 653
Query: 1355 KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEM----EQFK 1410
+ K LE D L E + + A+ ++ +++ LN + NE + V + +
Sbjct: 654 EQKKRQLEESVDALSEELVQLRAQ-EKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETH 712
Query: 1411 PKDSALLRIEIE---------------MLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQ 1455
K + LR E+E M+ +RL+ H+++K+ +EK V+Q
Sbjct: 713 QKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQ 772
Query: 1456 SESDQLKENIK---EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQK 1512
+Q ++++K E VAK L+T L+ + T + + +T S QK
Sbjct: 773 DRREQARQDLKGLEETVAKELQTLHNLRK---LFVQDLATRVKKSAEIDSDDTGGSAAQK 829
Query: 1513 QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKML 1572
Q + + ++ +++++ + N E+ + L+ E KA +SAL+ +
Sbjct: 830 QKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAS 889
Query: 1573 ELTNRLQESQEEIQIMIKEKEEMKRVQEA 1601
R Q+ + I+ ++ K +R A
Sbjct: 890 RDRKRYQQEVDRIKEAVRSKNMARRGHSA 918
Score = 50.4 bits (119), Expect = 2e-05
Identities = 114/631 (18%), Positives = 255/631 (40%), Gaps = 92/631 (14%)
Query: 2009 QNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIAR 2068
+N +V + Q KK + E+ +I+ R+ ++ ++ L R+ + E +
Sbjct: 326 KNTVCVNVELTAEQWKKKYEKEKEKNKIL---RNTIQWLENELNRWRNGETVPIDEQFDK 382
Query: 2069 DRQNHQ---VKPEKRLLSDGQQ-------HLTESLREKCSRIKELLKRYSEMDDHYECLN 2118
++ N + V + L +D + T++ R KC +E+ K Y ++DD E +N
Sbjct: 383 EKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCE--EEIAKLYKQLDDKDEEIN 440
Query: 2119 RLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLS 2178
+ Q++ +EKL T M + +L+
Sbjct: 441 Q----------------------------QSQLVEKLKTQ-----------MLDQEELLA 461
Query: 2179 YVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLH 2238
+ ++ +N+ + + E+ KE+L ++ L + D S+E+ D + +L
Sbjct: 462 STRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDK--TKEYELL 519
Query: 2239 IEEILKDFSESEFPSIKTEFQQVLS----NRKEMTQFLEEWLNTRFDIE-KLKNGIQKEN 2293
+E+ + + SI E Q++ +K + + L +I + N K+
Sbjct: 520 SDELNQ--KSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQP 577
Query: 2294 DRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSL 2353
+ ++ F + I +E + T+ K +Q + E N+K+ +N + L
Sbjct: 578 EGTGMIDEEFTVARLYISKMKSEVK----TMVKRCKQLESTQTESNKKMEENEKEL---- 629
Query: 2354 ASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESA--MHKESKIIKMQKE- 2410
+ Q+ + + K +T Q +K R+LE S+ E + + K+ +M+KE
Sbjct: 630 -AACQLRISQHEAKIKSLTEYL-QNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEH 687
Query: 2411 ---LEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKI 2467
++ N++ ++ ++ + +K I L+D+V AK + ++D K++ +
Sbjct: 688 LNKVQTANEVKQAVEQQIQSHRETHQKQ---ISSLRDEVEAKAKLITD-LQDQNQKMM-L 742
Query: 2468 DLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKP 2527
+ E+++ E K K+ ++ V++ RE R+ + + +V E K
Sbjct: 743 EQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKL 802
Query: 2528 LTCGGGSGIVQNTK--------ALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQH 2579
+ + ++ + + K + LE + +L + ++QL++ +L
Sbjct: 803 FVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPK 862
Query: 2580 LSNEVKTWKERTLKREAHKQVTCENSPKSPK 2610
L ++ ER E+ + EN+ + K
Sbjct: 863 LEKRLRATAERVKALESALKEAKENASRDRK 893
>gi|4758650 kinesin family member 5C [Homo sapiens]
Length = 957
Score = 293 bits (751), Expect = 1e-78
Identities = 296/1048 (28%), Positives = 480/1048 (45%), Gaps = 167/1048 (15%)
Query: 4 EGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVY 63
E ++ V R RPLN E G+ +K D V+ + K + FDRV N T + VY
Sbjct: 6 ECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVV--IGQGKPYVFDRVLPPNTTQEQVY 63
Query: 64 EEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMG---SEDHLGVIPRAIHDIFQKIKKF 120
A I+ ++GYNGTIFAYGQT+SGKT+TM G +G+IPR HDIF I
Sbjct: 64 NACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSM 123
Query: 121 PDR-EFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMAL 179
+ EF ++VSY EIY + I DLL L + ED NR YV TE V + E +
Sbjct: 124 DENLEFHIKVSYFEIYLDKIRDLL--DVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVM 181
Query: 180 KWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVS-HLNLVDLAG 238
I +G+ +RH T MN+ SSRSH+IF + ++ N E K+S L LVDLAG
Sbjct: 182 DVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQ------ENVETEKKLSGKLYLVDLAG 235
Query: 239 SERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGG 298
SE+ ++TGA G L E NIN+SL LG VI L++G + YRDSK+TRILQ+SLGG
Sbjct: 236 SEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEG-TKTHVPYRDSKMTRILQDSLGG 294
Query: 299 NAKTRIICTITPVSFD--ETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLK 356
N +T I+ +P F+ ET + L F AK +KNT VN T E K+Y KE
Sbjct: 295 NCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKE----- 349
Query: 357 KQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAK 416
EK++ K+++Q ++ E L R ++ +++ AK
Sbjct: 350 --------------KEKNKTL-----KNVIQHLEME----LNRWR-NGEAVPEDEQISAK 385
Query: 417 RKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCS---ESDVFS 473
++ + C D I NI +S + DE + S + D
Sbjct: 386 DQKNLEPC-------------DNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKD 432
Query: 474 NTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKND 533
+ ++ S++ ++L+Q+ + L S R DY+ + + +L+ E E + ++KE
Sbjct: 433 DEINQQSQLAEKLKQQMLDQDEL---LASTRRDYEKIQEELTRLQIENEAAKDEVKE--- 486
Query: 534 LDEFEALER-KTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIK 592
+ALE DQ+ Q + + + N+ L +EL+ K L + ++
Sbjct: 487 --VLQALEELAVNYDQKSQEVEDKTRA----------NEQLTDELAQKTTTLTTTQRELS 534
Query: 593 KLQEYIDSQK-----LENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSE 647
+LQE + QK + N+ + + I +K TL D V + E R
Sbjct: 535 QLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVK-TLADVNGV---IEEEFTMARLY 590
Query: 648 NLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGK 707
++K ++K L KQ+E+ +Q+++ +KM E+EL + I++ + I K
Sbjct: 591 ISKMKSEVKSLVNRSKQLES------AQMDSNRKMNAS-ERELAACQLLISQHEAKI--K 641
Query: 708 VPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKS 767
D + N+E + +++EE++ SL E+ +LR Q+K
Sbjct: 642 SLTDYMQNME----------QKRRQLEESQ------------DSLSEELAKLR--AQEKM 677
Query: 768 EELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHM 827
E+ EK+ L +R+Q + K+ +Q+ ++ + H
Sbjct: 678 HEVSFQDKEKEHL--------TRLQ--------------DAEEMKKALEQQMESHREAHQ 715
Query: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLN 887
+ + +EE +++ EI +L+++ Q L + +L + QE + K ++ +
Sbjct: 716 KQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLND 775
Query: 888 EMEQLKEQLENRDST----LQTVEREKTLITEKLQQTLEEVKTLTQEKDD------LKQL 937
+ EQ +E L+ + T LQT+ + L + L T K++ + DD KQ
Sbjct: 776 KREQAREDLKGLEETVSRELQTLHNLRKLFVQDL--TTRVKKSVELDNDDGGGSAAQKQK 833
Query: 938 QESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHM 997
L+ +QL V N D + +L + L+ E + L+S + E
Sbjct: 834 ISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKE-------A 886
Query: 998 EENTGETKDEFQQKMVGIDKKQDLEAKN 1025
+EN + +QQ++ I K+ + AKN
Sbjct: 887 KENAMRDRKRYQQEVDRI--KEAVRAKN 912
Score = 97.4 bits (241), Expect = 2e-19
Identities = 125/556 (22%), Positives = 239/556 (42%), Gaps = 83/556 (14%)
Query: 851 SKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREK 910
++E +K+D + +L ++L +K E+ ++ E+LK+Q+ ++D L + R+
Sbjct: 411 TEEKEKYDEEISSLY-------RQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDY 463
Query: 911 TLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMN----------- 959
I E+L + E + E ++ Q E L + DQ ++ D N
Sbjct: 464 EKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKT 523
Query: 960 --IDTQEQLRNALESLKQHQ-----ETINTLKSKISE-----EVSRNLHMEENTGETKDE 1007
+ T ++ + L+ L HQ E +N L + E + + + G ++E
Sbjct: 524 TTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEE 583
Query: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
F + I K + E K+ + ++ + ++ RK+ + +E Q ++ A+ +
Sbjct: 584 FTMARLYISKMKS-EVKSLVNRSKQLESAQ-MDSNRKMNASERELAACQLLISQHEAKIK 641
Query: 1068 QLKTDLKENIEMTIENQEELR-LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVE 1126
L TD +N+E EE + L +EL K + AQEK H + + + RL + E
Sbjct: 642 SL-TDYMQNMEQKRRQLEESQDSLSEELAK---LRAQEKMHEVSFQDKEKEHLTRLQDAE 697
Query: 1127 EKLKEKSQQLQE----KQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERL 1182
E K QQ++ Q+QL +++E+ E QK I+EI +L N++L LE
Sbjct: 698 EMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRDL-----NQKLQLEQ------ 746
Query: 1183 ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHI 1242
+KL+ +Y ++K +ER++ E +R+ Q +E+LK
Sbjct: 747 ---EKLSSDYNKLKIEDQEREMKLEKLLLLNDKRE--------------QAREDLKGLEE 789
Query: 1243 HLKEHQETIDELRR-SVSEKTAQIINTQDLEK----SHTKLQEEIPVLHEEQELLPNVKE 1297
+ +T+ LR+ V + T ++ + +L+ +++I L E L V +
Sbjct: 790 TVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENNLEQLTKVHK 849
Query: 1298 --VSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK 1355
V + + EL L ++ T R++ L E + + + K +E D
Sbjct: 850 QLVRDNADLRCELPKLEKRL----RATAERVKALESALKEAKENAMRDRKRYQQEVDR-- 903
Query: 1356 TIKEALEVKHDQLKEH 1371
IKEA+ K+ + H
Sbjct: 904 -IKEAVRAKNMARRAH 918
Score = 94.0 bits (232), Expect = 2e-18
Identities = 133/646 (20%), Positives = 292/646 (45%), Gaps = 79/646 (12%)
Query: 1173 TLEHMETERLEL-AQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGL 1231
T+++ + LEL A++ + YE+ K ++ K LK + + E E + R E +
Sbjct: 326 TIKNTVSVNLELTAEEWKKKYEKEK---EKNKTLKNVIQHLEMELNRWRNGEAVPEDEQI 382
Query: 1232 QTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQEL 1291
K++ + ++ ID + V+ I+T++ EK ++ L ++ +
Sbjct: 383 SAKDQKNLEPC---DNTPIIDNIAPVVAG-----ISTEEKEKYDEEISSLYRQLDDKDDE 434
Query: 1292 LPNVKEVSET--QETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTK 1349
+ +++E Q+ +++ ELL ST +D +I+ E RL + + +++E+K +
Sbjct: 435 INQQSQLAEKLKQQMLDQDELLA--STRRD---YEKIQEELTRLQIENEAAKDEVKEV-- 487
Query: 1350 ERDNLKTIKEALEVKHDQLKEHIRE-TLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408
L+ ++E L V +DQ + + + T A Q + +++ + E +++
Sbjct: 488 ----LQALEE-LAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNH 542
Query: 1409 FKPKDSALLRIEIEMLGLSKRLQESHD-----EMKSVAKEKDDLQRLQ-EVLQSESDQLK 1462
K + + +L + ++ LG + ++D ++ V +E+ + RL ++SE L
Sbjct: 543 QKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLV 602
Query: 1463 ENIKEIVAKHLET-------EEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLE 1515
K++ + +++ E EL + + E I L + E + ++QLE
Sbjct: 603 NRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQK----RRQLE 658
Query: 1516 AINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELT 1575
D L ++ ++ +E+ + + +E + L+ +E +KA + ++S +
Sbjct: 659 ESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQL 718
Query: 1576 NRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA 1635
+RL++ EE Q +I +E++ + + LQ+E+++L + ++ E QE+E + K+
Sbjct: 719 SRLRDEIEEKQKII---DEIRDLNQKLQLEQEKLSSDYNKLKI---EDQEREMKLEKLLL 772
Query: 1636 VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD----- 1690
+N+ +E+ E LK ET L+ + N+R + +SV + DD
Sbjct: 773 LNDKREQ--AREDLKGLEETVSRELQTL--HNLRKLFVQDLTTRVKKSVELDNDDGGGSA 828
Query: 1691 ---------LRSVEETLKVERDQLKEN--LRETITRDLEKQ-----EELKIVHMHLKEHQ 1734
++E+ KV + +++N LR + + LEK+ E +K + LKE +
Sbjct: 829 AQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPK-LEKRLRATAERVKALESALKEAK 887
Query: 1735 ETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH 1780
E + R E+ +++ + N A +A +I + +R H
Sbjct: 888 ENAMRDR---KRYQQEVDRIKEAVRAKNMARRAHSAQIAKPIRPGH 930
Score = 92.4 bits (228), Expect = 5e-18
Identities = 137/693 (19%), Positives = 302/693 (43%), Gaps = 118/693 (17%)
Query: 1293 PNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERD 1352
P+V +ET+ T+ + +++ T +T +E+ +K+++ +E+ K+L
Sbjct: 306 PSVFNEAETKSTL----MFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTL----- 356
Query: 1353 NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSL-------------------NMK 1393
K + + LE++ ++ + E + + ++ +K +++L + +
Sbjct: 357 --KNVIQHLEMELNRWRNG--EAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTE 412
Query: 1394 EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEV 1453
EK+ +I S Q KD I + K Q+ D+ + +A + D +++QE
Sbjct: 413 EKEKYDEEISSLYRQLDDKDD---EINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEE 469
Query: 1454 L---QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTI 1510
L Q E++ K+ +KE++ + + EL VN +K E+
Sbjct: 470 LTRLQIENEAAKDEVKEVL---------------------QALEELAVNYDQKSQEVEDK 508
Query: 1511 QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESK 1570
+ E + D+L K + + Q ++++L++ H+K + + + ++ K
Sbjct: 509 TRANEQLTDELAQKTTTL------------TTTQRELSQLQELSNHQKKRATEILNLLLK 556
Query: 1571 MLELTNRLQESQE-----EIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE 1625
L + + + ++ +I+E+ M R+ + ++K K +V + K+ +
Sbjct: 557 DLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYIS------KMKSEVKSLVNRSKQLES 610
Query: 1626 KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN--LENIETENIRLTQILHENLEEMRS 1683
+ + +E + C++ + + + + L ++N+E + +L E S
Sbjct: 611 AQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLE-------ESQDS 663
Query: 1684 VTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGI 1743
+++E LR+ E K+ ++ +E +TR + +E K + ++ H+E K
Sbjct: 664 LSEELAKLRAQE---KMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQ--- 717
Query: 1744 VSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLK-EQQETIDKLRGIVSEKTD 1802
+S +EI QK ++ D + L+ QE+L + LK E QE KL ++ D
Sbjct: 718 LSRLRDEIEEKQKIIDEIRDLNQKLQLE-QEKLSSDYNKLKIEDQEREMKLEKLLL-LND 775
Query: 1803 KLSNMQKDLENSNAKLQEKIQELKANEHQLITL-KKDVNETQKKVSEMEQLKKQIKDQSL 1861
K ++DL+ + ++Q L H L L +D+ KK E++ +
Sbjct: 776 KREQAREDLKGLEETVSRELQTL----HNLRKLFVQDLTTRVKKSVELD-------NDDG 824
Query: 1862 TLSKLEIENLNLAQKLHENLEEMKSVMKE--RDNLRRVEETLKLERDQLKESLQETKARD 1919
S + + ++ L NLE++ V K+ RDN E KLE+ +L+ + + KA +
Sbjct: 825 GGSAAQKQKISF---LENNLEQLTKVHKQLVRDNADLRCELPKLEK-RLRATAERVKALE 880
Query: 1920 LEIQQELKTARMLSKEHKETVDKLREKISEKTI 1952
+++ + A K +++ VD+++E + K +
Sbjct: 881 SALKEAKENAMRDRKRYQQEVDRIKEAVRAKNM 913
Score = 90.9 bits (224), Expect = 2e-17
Identities = 142/767 (18%), Positives = 329/767 (42%), Gaps = 73/767 (9%)
Query: 1143 LLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKER 1202
L+N+++E E +KK++ L + +++++ E L+ A+ +N++ + ++
Sbjct: 210 LINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVI--- 266
Query: 1203 KVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKT 1262
L E K+ RD I + G + + ET L KT
Sbjct: 267 SALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKT 326
Query: 1263 AQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV---KEVSETQETMNELELLTEQSTTKD 1319
+ + +LE + + +++ E+ + L NV E+ + E EQ + KD
Sbjct: 327 IKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKD 386
Query: 1320 STTLARIEMERLRLN----------EKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK 1369
L + + N E+ ++ EEI SL ++ D+ K D++
Sbjct: 387 QKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDD----------KDDEIN 436
Query: 1370 EHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKR 1429
+ + K+++ Q++ L +D E KI E+ + + ++ A E+L +
Sbjct: 437 QQ-SQLAEKLKQQMLDQDELLASTRRDYE--KIQEELTRLQIENEAAKDEVKEVLQALEE 493
Query: 1430 LQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ 1489
L ++D+ ++E +D R E L +D+L + + E + ++++ K
Sbjct: 494 LAVNYDQK---SQEVEDKTRANEQL---TDELAQKTTTLTTTQRELSQLQELSNHQKKRA 547
Query: 1490 EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNE 1549
E +N L +L E I T ++ + D + I+E + + K SEV+ VN
Sbjct: 548 TEILNLLLKDLGEIGGIIGT--NDVKTLAD-VNGVIEEEFTMARLYISKMKSEVKSLVNR 604
Query: 1550 LKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQL 1609
KQ + + + + + E ++ + + + +I+ + + M++ + L+ +D L
Sbjct: 605 SKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSL 664
Query: 1610 KENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIR 1669
E +AK++ +QEK ++ E ++ + E +K+ E Q +E+ + +
Sbjct: 665 SEE----LAKLR-AQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQ---MESHREAHQK 716
Query: 1670 LTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMH 1729
L + +EE + + D++R + + L++E+++L + + D E++ +L+ + +
Sbjct: 717 QLSRLRDEIEEKQKII---DEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLL 773
Query: 1730 LKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789
+ ++ + L+G+ + E+ + H+ L QDL + +K+ E
Sbjct: 774 NDKREQAREDLKGLEETVSRELQTL-----HNLRKLFVQDLTTR---------VKKSVEL 819
Query: 1790 IDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849
+ G + + K+S ++ +LE ++ +++ +L L+K + T ++V +
Sbjct: 820 DNDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKAL 879
Query: 1850 EQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRR 1896
E K+ K+ ++ K + + ++ +K ++ ++ RR
Sbjct: 880 ESALKEAKENAMRDRK----------RYQQEVDRIKEAVRAKNMARR 916
Score = 79.0 bits (193), Expect = 6e-14
Identities = 109/513 (21%), Positives = 231/513 (45%), Gaps = 57/513 (11%)
Query: 1731 KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI 1790
+++ E I L + +K +EI N Q L + LK Q L E L ++ QE +
Sbjct: 415 EKYDEEISSLYRQLDDKDDEI-NQQSQLA---EKLKQQMLDQDELLASTRRDYEKIQEEL 470
Query: 1791 DKLRGIVSEKTDKLSNMQKDLE----NSNAKLQEKIQELKANEH---QLITLKKDVNETQ 1843
+L+ D++ + + LE N + K QE + +ANE +L + TQ
Sbjct: 471 TRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQ 530
Query: 1844 KKVSEMEQLKKQIKDQSLTLSKLEIENLN-----LAQKLHENLEEMKSVMKERDNLRRV- 1897
+++S++++L K ++ + L +++L + + L ++ V++E + R+
Sbjct: 531 RELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLY 590
Query: 1898 ------EETLKLERDQLKESLQETKARDLEI-QQELKTARMLSKEHKETVDKLREKISEK 1950
E + R + ES Q R + ++EL ++L +H+ + L + +
Sbjct: 591 ISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQN- 649
Query: 1951 TIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSH-KKINEMEQLKKQFEAQ 2009
+ ++ L++S+D L +++ +L+ +E +D H ++ + E++KK E Q
Sbjct: 650 ---MEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQ 706
Query: 2010 NLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARD 2069
M+S R + + +L + +EE + + DE+R + + L++E+++ + ++ D
Sbjct: 707 ---MESHREAHQKQLSRLRDEIEEKQKII---DEIRDLNQKLQLEQEKLSSDYNKLKIED 760
Query: 2070 RQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECL--NRLSLDLEKE 2127
Q ++K EK LL + ++ E RE ++E + R + + L L+ ++K
Sbjct: 761 -QEREMKLEKLLLLNDKR---EQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKS 816
Query: 2128 IEF----------QKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVL 2177
+E QK+ ++ NL TK ++L N E ++ K+L+
Sbjct: 817 VELDNDDGGGSAAQKQKISFLENNLE---QLTKVHKQLVRDNADLRCELPKLEKRLRATA 873
Query: 2178 SYVTKIK---EEQHESINKFEMDFIDEVEKQKE 2207
V ++ +E E+ + + EV++ KE
Sbjct: 874 ERVKALESALKEAKENAMRDRKRYQQEVDRIKE 906
Score = 53.9 bits (128), Expect = 2e-06
Identities = 149/769 (19%), Positives = 301/769 (39%), Gaps = 91/769 (11%)
Query: 1882 EEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941
EE+ V+ E R V T E S+ + ++ E K + L +
Sbjct: 178 EEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSE 237
Query: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQK--------KELQLLRVKED----- 1988
K+ + +E + D K+++KS L I L + ++ ++ R+ +D
Sbjct: 238 KVSKTGAEGAVL--DEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGN 295
Query: 1989 ------VNMSHKKINEMEQLKK-QFEAQNLSMQSVRMDNFQLT----KKLHESLEEIRIV 2037
+ S NE E F + ++++ N +LT KK +E +E
Sbjct: 296 CRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKE---- 351
Query: 2038 AKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKC 2097
+ L+ + + L+ME +++ E + D Q K +K L + +++
Sbjct: 352 --KNKTLKNVIQHLEMELNRW--RNGEAVPEDEQI-SAKDQKNLEPCDNTPIIDNIAPVV 406
Query: 2098 SRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANL----SLPYLQTKHIE 2153
+ I K + D+ L R D + EI Q +L+ ++K + L + E
Sbjct: 407 AGISTEEKE--KYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYE 464
Query: 2154 KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQ 2213
K+ R +E ++K VL + ++ + + E D+ ++L ++
Sbjct: 465 KIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVE----DKTRANEQLTDELA 520
Query: 2214 HLQQDCDVPSRELRDLK-LNQNMDLHIEEIL----KDFSESEFPSIKTEFQQVLSNRKEM 2268
REL L+ L+ + EIL KD E I T + L++ +
Sbjct: 521 QKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIG-GIIGTNDVKTLADVNGV 579
Query: 2269 TQFLEEWLNTRFDIEKLKNGIQKENDRICQVNN--FFNNRIIAIMNESTEFEERSATISK 2326
+ EE+ R I K+K+ ++ +R Q+ + +NR MN S +
Sbjct: 580 IE--EEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRK---MNASERELAACQLLIS 634
Query: 2327 EWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIREL 2386
+ E +KSL + + + + + L+ S S ++ + + H S +K +E
Sbjct: 635 QHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVS-----FQDKEKEH 689
Query: 2387 ENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKET---IQVLQ 2443
L +A+E E + M+ E +++L+ ++ E K +++ ++ +Q+ Q
Sbjct: 690 LTRLQDAEEMKKALEQQ---MESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQ 746
Query: 2444 DKVALGAKPYKEEIEDLKMKLVKIDL--EKMKNAKEFEKEISATKATVEYQKEVIRLLRE 2501
+K++ K E ++ +MKL K+ L +K + A+E ++ + TV + + + LR+
Sbjct: 747 EKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQARE---DLKGLEETVSRELQTLHNLRK 803
Query: 2502 NLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQ 2561
+ + + D GG Q K L E + +L +
Sbjct: 804 LFVQDLTTRVKKSVELDNDD----------GGGSAAQKQKISFL-------ENNLEQLTK 846
Query: 2562 QNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPK 2610
++QL++ +L L ++ ER E+ + EN+ + K
Sbjct: 847 VHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRK 895
Score = 52.8 bits (125), Expect = 5e-06
Identities = 146/801 (18%), Positives = 323/801 (40%), Gaps = 182/801 (22%)
Query: 1763 DALKAQDLKIQEELRIAH--MHLKEQQETIDKLRGIVSEKTDK-----LSNMQKDLENSN 1815
D + + D ++ +++++ ++L + ++ +D + ++ DK + + +S
Sbjct: 118 DHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSP 177
Query: 1816 AKLQEKIQELKANEHQ----------------LITLKKDVNETQKKVSEMEQLKKQIKDQ 1859
++ + I E KAN H LI +K++ ET+KK+S L +
Sbjct: 178 EEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSE 237
Query: 1860 SLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQ-----LKESL-- 1912
++ + E L+ A+ ++++L + +V+ L +T RD L++SL
Sbjct: 238 KVSKTGAEGAVLDEAKNINKSLSALGNVISA---LAEGTKTHVPYRDSKMTRILQDSLGG 294
Query: 1913 -----------------QETKARDLEIQQELKTAR--------MLSKEHKETVDKLREKI 1947
ETK+ L Q KT + + ++E K+ +K +EK
Sbjct: 295 NCRTTIVICCSPSVFNEAETKS-TLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKN 353
Query: 1948 SEKTIQISDIQKDLDKSKD-ELQKKIQELQKKELQLLR------VKEDVNMSHKKINEME 2000
I ++ +L++ ++ E + +++ K+ + L + +++ I+ E
Sbjct: 354 KTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEE 413
Query: 2001 QLKKQFEAQNLSMQSVRMDN-----FQLTKKL-HESLEEIRIVAKERDELRRIKESL--- 2051
+ K E +L Q D+ QL +KL + L++ ++A R + +I+E L
Sbjct: 414 KEKYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRL 473
Query: 2052 -------KMERDQFIATLREM-IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI--- 2100
K E + + L E+ + D+++ +V+ + R + LT+ L +K + +
Sbjct: 474 QIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTR----ANEQLTDELAQKTTTLTTT 529
Query: 2101 KELLKRYSEMDDHY-----ECLNRLSLDL----------------------EKEIEFQKE 2133
+ L + E+ +H E LN L DL E+E +
Sbjct: 530 QRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARL 589
Query: 2134 LSMRVKANLSLPYLQTKHIE-------KLFTANQR----CSMEFHRIMKKLKYVLSYVTK 2182
++K+ + ++K +E + A++R C + + K+K + Y+
Sbjct: 590 YISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQN 649
Query: 2183 IK------EEQHESIN--------KFEMDFIDEVEKQKELLIKI-----------QHLQQ 2217
++ EE +S++ + +M + +K+KE L ++ Q ++
Sbjct: 650 MEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMES 709
Query: 2218 DCDVPSRELRDLK---------------LNQNMDLHIEEILKDFSESEFPSIKTEFQQVL 2262
+ ++L L+ LNQ + L E++ D+++ +K E Q+
Sbjct: 710 HREAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNK-----LKIEDQERE 764
Query: 2263 SNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSA 2322
+++ ++ R D++ L+ + +E + + F + + +S E +
Sbjct: 765 MKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDG 824
Query: 2323 TISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEK 2382
S +Q + L+ E+L K ++ L A P + + + T E+
Sbjct: 825 GGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLE---------KRLRATAER 875
Query: 2383 IRELENSLHEAKESAMHKESK 2403
++ LE++L EAKE+AM +
Sbjct: 876 VKALESALKEAKENAMRDRKR 896
>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
Length = 1317
Score = 292 bits (747), Expect = 3e-78
Identities = 340/1262 (26%), Positives = 568/1262 (45%), Gaps = 146/1262 (11%)
Query: 6 AVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQV------------DGSKSFNFDRVF 53
+V V VRVRP+N RE+ L + + I + + +K+F +D F
Sbjct: 3 SVKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDFSF 62
Query: 54 HGNETT-------KNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVI 106
+ +T + V++ + ++ SA +GYN +FAYGQT SGK+YTMMG+ G+I
Sbjct: 63 YSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLI 122
Query: 107 PRAIHDIFQKIK---KFPDREFLLRVSYMEIYNETITDLL-CGTQKMKPLIIREDVNRNV 162
PR +F +I ++ + F VSY+EIYNE + DLL + K L +RE
Sbjct: 123 PRICEGLFSRINETTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGP 182
Query: 163 YVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNC 222
YV DL++ +V + + G +R T MN SSRSH IF + + C
Sbjct: 183 YVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFDSEMPC 242
Query: 223 EGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGG--- 279
E VS ++LVDLAGSERA TGA GVRLKEG NIN+SL LG VI L+D
Sbjct: 243 E---TVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANT 299
Query: 280 -------FINYRDSKLTRILQNSLGGNAKTRIICTITP--VSFDETLTALQFASTAKYMK 330
F+ YRDS LT +L++SLGGN+KT +I TI+P V++ ETL+ L++A+ AK +
Sbjct: 300 LAKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNII 359
Query: 331 NTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQ 390
N P +NE + L++ R EI LK L + A+ A +EEK LQ Q
Sbjct: 360 NKPTINE-DANVKLIRELRAEIARLKTLL----AQGNQIALLDSPTALSMEEK--LQ--Q 410
Query: 391 NE-KIENLTRMLVTSSSLT---LQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNI 446
NE +++ LT+ + T L+++ A RK + L +++ + D + T I
Sbjct: 411 NEARVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLD--SELPHLIGIDDDLLSTGI 468
Query: 447 TTKTHKLSINLLREIDES-----------VCSESDVFSNTLDTLSEIEWNPATKLLNQEN 495
K + D S + SE +F N T++ I + + +N
Sbjct: 469 ILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHCIFENIGGTVTLIPLSGSQCSVNGVQ 528
Query: 496 IESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQL-IH 554
I E L L+ R + KL+EK RK+ L +
Sbjct: 529 I-VEATHLNQGAVILLGRTNMFRFNHPKEAAKLREK----------RKSGLLSSFSLSMT 577
Query: 555 EISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSL 614
++S + + +YN LE E + EL EK + +KL E ++ +K ++ K +L
Sbjct: 578 DLSKSRENLSAVMLYNPGLEFERQQREEL--EKLESKRKLIEEME-EKQKSDKAELERMQ 634
Query: 615 ESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS 674
+ +E Q K+T E V L +++ L+ + ++ K+K+L ++ E + Q
Sbjct: 635 QEVE--TQRKET----EIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEERLREQQ 688
Query: 675 QLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVE 734
++E +KK Q E+ E+ +L L + + + EL+ LQKE +++
Sbjct: 689 EIELQKKRQE--EETFLRVQEELQRLKELNNNEKAEKFQIFQELD----QLQKEKDEQYA 742
Query: 735 ENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGL 794
+ E E+ L + K V L +++++K E + ++ + + E ++ ++G+
Sbjct: 743 KLEL--EKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEE---EKRDLEGI 797
Query: 795 LEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEA 854
E + + K+ A + + E + Q K+V E + + Q+ + L KE
Sbjct: 798 RESLLRVKE--ARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDI-LKKEV 854
Query: 855 QKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT 914
Q+ L LK E K L EK E + E+ Q E+++ + LQ ER+
Sbjct: 855 QEEQEILECLKCEHD-KESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQ----- 908
Query: 915 EKLQQTLE-EVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESL 973
LQ L+ + TL +EK ++ ++R L D N ++++ E L
Sbjct: 909 --LQYLLQNHLPTLLEEKQRAFEI-----LDRGPLSLD-----NTLYQVEKEMEEKEEQL 956
Query: 974 KQHQETINTL-KSKISEEVSRNLHMEENTGETKD-------EFQQKMVGIDKKQDLEAKN 1025
Q+Q N L K + + E + N+ +E K+ E QQ+ LE ++
Sbjct: 957 AQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRH 1016
Query: 1026 TQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQE 1085
+ EI EQ++K+ SL E + S+ AE+E L+ D +E +E I+ +
Sbjct: 1017 SALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKD-QERLEYEIQQLK 1075
Query: 1086 ELRLLGDELKKQQEIVAQEK--NHAIKKEGELSRTCDRL-----AEVEEKLKEKSQQLQE 1138
+ D ++K + K + ++ E S + A +EE+++ + Q L
Sbjct: 1076 QKIYEVDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDLHR 1135
Query: 1139 KQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSI 1198
+ E S + + E L N ++L E M +++ L N +++K
Sbjct: 1136 V------ISEGCSTSADTMKDNEKLHNGTIQRKLKYERM------VSRSLGANPDDLKDP 1183
Query: 1199 TK 1200
K
Sbjct: 1184 IK 1185
Score = 112 bits (279), Expect = 6e-24
Identities = 191/877 (21%), Positives = 388/877 (44%), Gaps = 159/877 (18%)
Query: 1159 EIENLKNEL-KNKELTLEHMETERLELAQKLNENYEEVKSITKE--------RKVLKE-- 1207
EI LK L + ++ L T L + +KL +N V+ +TKE + +LKE
Sbjct: 379 EIARLKTLLAQGNQIALLDSPTA-LSMEEKLQQNEARVQELTKEWTNKWNETQNILKEQT 437
Query: 1208 --LQKS-----FETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
L+K ++E HL G ++ +TG I HLKE Q + R S
Sbjct: 438 LALRKEGIGVVLDSELPHLIGIDDDLLSTG--------IILYHLKEGQTYVG--RDDAST 487
Query: 1261 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS 1320
+ +++ DLE H + + L+P +S +Q ++N ++++ + +
Sbjct: 488 EQDIVLHGLDLESEHCIFEN----IGGTVTLIP----LSGSQCSVNGVQIVEATHLNQGA 539
Query: 1321 T-TLARIEMERLRLNEKFQESQEEIKS------------LTKERDNLKTI---KEALEVK 1364
L R M R ++ + +E+ KS L+K R+NL + LE +
Sbjct: 540 VILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFE 599
Query: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424
Q RE L K++ + K++ EME+ + D A
Sbjct: 600 RQQ-----REELEKLESKR-----------------KLIEEMEEKQKSDKA--------- 628
Query: 1425 GLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC 1484
L + QE + K + +++ +E L+ S ++ +K+++A+ + EEE
Sbjct: 629 ELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEER----- 683
Query: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
L+EQ+E EL+ E+ET + +Q++L+ + + N EK E+F I Q +
Sbjct: 684 -LREQQEI--ELQKKRQEEETFL-RVQEELQRLKELNNN------EKAEKFQIFQELDQL 733
Query: 1545 EKVNELKQFKEHRKAKDSALQSIESKML--ELTNRLQESQEEIQIMIK--------EKEE 1594
+K + + K + K Q E ML L +L+E QE IQ++ + EK +
Sbjct: 734 QKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEEEKRD 793
Query: 1595 MKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLK---MTAVNETQEKMCEIEHLKE 1651
++ ++E+L + + + E +++++Q + ++F + + VN ++ + + + LK+
Sbjct: 794 LEGIRESL-LRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKK 852
Query: 1652 QFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD---LRSVEETLKVERDQLKEN 1708
+ + ++ LE ++ E+ + +++L ++ E + VT+ D ++ VE L+ + QL+
Sbjct: 853 EVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQYL 912
Query: 1709 LRETITRDL-EKQEELKIVHMHLKEHQETIDKLRGIVSEK----------TNEISNMQKD 1757
L+ + L EKQ +I+ T+ ++ + EK N++ +Q
Sbjct: 913 LQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQLQKLQAT 972
Query: 1758 LEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKL---SNMQKDLE-- 1812
E + + + ++ ++E I K+Q+E +++ + + L S + ++E
Sbjct: 973 FEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIEEQ 1032
Query: 1813 -------NSNAKLQEKIQ-----ELKANEHQLITLKKDVNETQKKVSEMEQLKK------ 1854
NS ++ Q +Q E +A E L+ ++ + ++K+ E++ ++K
Sbjct: 1033 RQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTL 1092
Query: 1855 --QIKDQSLTLSKLEIENLNLAQ-KLHENLEEMKSVMKERDNLRRV-EETLKLERDQLKE 1910
++ SL +S + + L +++ +EE V + +L RV E D +K+
Sbjct: 1093 EGKVASSSLPVSAEKSHLVPLMDARINAYIEE--EVQRRLQDLHRVISEGCSTSADTMKD 1150
Query: 1911 SLQETKARDLEIQQELKTARMLSKEHKETVDKLREKI 1947
+ K + IQ++LK RM+S+ D L++ I
Sbjct: 1151 N---EKLHNGTIQRKLKYERMVSRSLGANPDDLKDPI 1184
Score = 90.1 bits (222), Expect = 3e-17
Identities = 105/516 (20%), Positives = 235/516 (45%), Gaps = 62/516 (12%)
Query: 1679 EEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETID 1738
EE+ + +R + +EE K ++ +L+ +E T+ ++E +IV + +++ +E++
Sbjct: 604 EELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQ----RKETEIVQLQIRKQEESLK 659
Query: 1739 KLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQ-----QETIDKL 1793
+ ++ I N KDL + + + L+ Q+E+ + +E+ QE + +L
Sbjct: 660 R-------RSFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQRL 712
Query: 1794 RGIVS-EKTDK------LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKV 1846
+ + + EK +K L +QK+ + AKL+ + + L+ E + + L + E ++
Sbjct: 713 KELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREK 772
Query: 1847 SEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE-ETLKLER 1905
EM QL ++ + Q + K ++E + + L E ++ + L + + + +R
Sbjct: 773 QEMIQLLRRGEVQWVEEEKRDLEGIR--ESLLRVKEARAGGDEDGEELEKAQLRFFEFKR 830
Query: 1906 DQL-------KESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQ 1958
QL K+ +Q+ E+Q+E + L EH + +L EK E ++++
Sbjct: 831 RQLVKLVNLEKDLVQQKDILKKEVQEEQEILECLKCEH-DKESRLLEKHDESVTDVTEVP 889
Query: 1959 KDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRM 2018
+D +K K + LQ KE QL + + + +E+ ++ FE + S+
Sbjct: 890 QDFEKIKPVEYR----LQYKERQLQYL-----LQNHLPTLLEEKQRAFEILDRGPLSLDN 940
Query: 2019 DNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQV-KP 2077
+Q+ K++ E E++ ++L++++ + +F A + RQ +V K
Sbjct: 941 TLYQVEKEMEEKEEQLAQYQANANQLQKLQATF-----EFTANIA------RQEEKVRKK 989
Query: 2078 EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMR 2137
EK +L ++ E+L +R++ +R+S + H + L +++E++ + L+
Sbjct: 990 EKEILESREKQQREALERALARLE---RRHSALQRH----STLGMEIEEQRQKLASLNSG 1042
Query: 2138 VKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKL 2173
+ L E L +R E ++ +K+
Sbjct: 1043 SREQSGLQASLEAEQEALEKDQERLEYEIQQLKQKI 1078
Score = 89.4 bits (220), Expect = 4e-17
Identities = 196/891 (21%), Positives = 370/891 (41%), Gaps = 123/891 (13%)
Query: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
STL+ R K +I + VK + + + ++ +L+ L D ++M
Sbjct: 347 STLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEE 406
Query: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
Q+ E K+ N ++ + E+ +E G D ++GID D
Sbjct: 407 KLQQNEARVQELTKEWTNKWNETQNILKEQTLAL--RKEGIGVVLDSELPHLIGID--DD 462
Query: 1021 L--------EAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE-----LQQMLESVIAEKE 1067
L K QT +D+ EQ + L E + + +
Sbjct: 463 LLSTGIILYHLKEGQTYVG--RDDASTEQDIVLHGLDLESEHCIFENIGGTVTLIPLSGS 520
Query: 1068 QLKTDLKENIEMTIENQEELRLLG-------DELKKQQEIVAQEKNHAIKKEG----ELS 1116
Q + + +E T NQ + LLG + K+ ++ + K+ + +LS
Sbjct: 521 QCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLS 580
Query: 1117 RTCDRLA---------EVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN-EIENLKNE 1166
++ + L+ E E + +E+ ++L+ K++ + EEM E QK E+E ++ E
Sbjct: 581 KSRENLSAVMLYNPGLEFERQQREELEKLESKRKLI----EEMEEKQKSDKAELERMQQE 636
Query: 1167 LKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL---QKSFETERDHLRGYI 1223
++ + ETE ++L + E + +S E K LK+L ++ FE ER +
Sbjct: 637 VET-----QRKETEIVQLQIRKQEESLKRRSFHIENK-LKDLLAEKEKFEEER------L 684
Query: 1224 REIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIP 1283
RE + LQ K + + + ++E + + EL + + QI Q+L++ + E+
Sbjct: 685 REQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIF--QELDQLQKEKDEQYA 742
Query: 1284 VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEE 1343
L E++ L E E ++ M L EQ K EM +L + Q +EE
Sbjct: 743 KLELEKKRL----EEQEKEQVMLVAHL-EEQLREKQ-------EMIQLLRRGEVQWVEEE 790
Query: 1344 IKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIV 1403
+ L R++L +KEA D+ E + + + E + +Q L EKD K +
Sbjct: 791 KRDLEGIRESLLRVKEA-RAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDI 849
Query: 1404 SEME-QFKPKDSALLRIEIEMLGLSKRLQESHDE-MKSVAKEKDDLQRLQEV---LQSES 1458
+ E Q + + L+ E + RL E HDE + V + D ++++ V LQ +
Sbjct: 850 LKKEVQEEQEILECLKCEHDK---ESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKE 906
Query: 1459 DQLKENIKEIVAKHLETEEE-LKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAI 1517
QL+ ++ + LE ++ ++ + T+ ++ + EKE +++ Q +
Sbjct: 907 RQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQL 966
Query: 1518 NDKLQNKIQ---EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK----DSALQSIESK 1570
KLQ + I +EE+ K+ ++ + + ++ E A+ SALQ +
Sbjct: 967 Q-KLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTL 1025
Query: 1571 MLELTNRLQE---------SQEEIQIMIK-EKEEMKRVQEALQIERDQLKENTKEIVAKM 1620
+E+ + Q+ Q +Q ++ E+E +++ QE L+ E QLK+ E+
Sbjct: 1026 GMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQ 1085
Query: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680
K+ + L+ + + E HL + ++N IE E R Q LH + E
Sbjct: 1086 KD----HHGTLEGKVASSSLPVSAEKSHLVPLMDA-RIN-AYIEEEVQRRLQDLHRVISE 1139
Query: 1681 MRSVT----KERDDLR--SVEETLKVER----------DQLKENLRETITR 1715
S + K+ + L +++ LK ER D LK+ ++ +I R
Sbjct: 1140 GCSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPR 1190
Score = 80.9 bits (198), Expect = 2e-14
Identities = 136/638 (21%), Positives = 260/638 (40%), Gaps = 86/638 (13%)
Query: 787 KESRVQGLLEEIGKTKDDLATTQSNYKSTD----------------QEFQNFKTLHMDFE 830
+E R GLL + DL+ ++ N + ++ ++ + L + E
Sbjct: 561 REKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFERQQREELEKLESKRKLIEEME 620
Query: 831 QKYKMVLEENERMNQEIVNLSKEAQ-------KFDSSLGALKTELSYKTQEL-QEKTREV 882
+K K E ERM QE+ KE + K + SL + K ++L EK +
Sbjct: 621 EKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFE 680
Query: 883 QERLNEMEQLKEQLENRDS-TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQES- 940
+ERL E ++++ Q + ++ T V+ E + E E + QE D L++ ++
Sbjct: 681 EERLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQ 740
Query: 941 ---LQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHM 997
L++E+ +L+ + V + +EQLR + QE I L+ + V
Sbjct: 741 YAKLELEKKRLEEQEKEQVMLVAHLEEQLR-------EKQEMIQLLRRGEVQWVEEEKRD 793
Query: 998 EENTGETKDEFQQKMVGIDKKQD---------LEAKNTQTLTADVKDNEIIEQQRKIFSL 1048
E E+ ++ G D+ + E K Q + + ++++Q+ +
Sbjct: 794 LEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKE 853
Query: 1049 IQEKNELQQML------ESVIAEK-EQLKTDLKE---------NIEMTIENQEELRLLGD 1092
+QE+ E+ + L ES + EK ++ TD+ E +E ++ +E R L
Sbjct: 854 VQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKE--RQLQY 911
Query: 1093 ELKKQQEIVAQEKNHA--IKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM 1150
L+ + +EK A I G LS + L +VE++++EK +QL + Q +Q+
Sbjct: 912 LLQNHLPTLLEEKQRAFEILDRGPLSLD-NTLYQVEKEMEEKEEQLAQYQANANQLQKLQ 970
Query: 1151 SEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQK 1210
+ + N + K ++ LE E ++ E ++ E S + L
Sbjct: 971 ATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHST---LGM 1027
Query: 1211 SFETERDHLRGY-IREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269
E +R L E +GLQ L+ L++ QE ++ + + +K ++ Q
Sbjct: 1028 EIEEQRQKLASLNSGSREQSGLQA--SLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQ 1085
Query: 1270 DLEKSHTKLQ-----EEIPVLHEEQELLP------NVKEVSETQETMNEL-ELLTEQSTT 1317
+ H L+ +PV E+ L+P N E Q + +L +++E +T
Sbjct: 1086 --KDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDLHRVISEGCST 1143
Query: 1318 KDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK 1355
T ++ + K + + +SL D+LK
Sbjct: 1144 SADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLK 1181
Score = 76.6 bits (187), Expect = 3e-13
Identities = 156/796 (19%), Positives = 333/796 (41%), Gaps = 160/796 (20%)
Query: 1283 PVLHEEQELLPNVKEVSETQETMNELELLTEQSTT---KDSTTLARIEMERLRLNEKFQE 1339
P ++E+ NVK + E + + L+ L Q DS T L + EK Q+
Sbjct: 362 PTINEDA----NVKLIRELRAEIARLKTLLAQGNQIALLDSPTA-------LSMEEKLQQ 410
Query: 1340 SQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNET 1399
++ ++ LTKE N E + +Q +E + + +S+ + + D +
Sbjct: 411 NEARVQELTKEWTN--KWNETQNILKEQTLALRKEGIGVVLDSELPHLIGI---DDDLLS 465
Query: 1400 TKIV----SEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQ 1455
T I+ E + + +D A +I + GL L+ H +++ ++
Sbjct: 466 TGIILYHLKEGQTYVGRDDASTEQDIVLHGLD--LESEHCIFENIGGTVT-------LIP 516
Query: 1456 SESDQLKENIKEIV-AKHLETEEELKVAHCCL----------KEQEETINELRVNLSEKE 1504
Q N +IV A HL + + + K +E+ + L + S
Sbjct: 517 LSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSM 576
Query: 1505 TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSAL 1564
T++S ++ L A+ L N E +E++++ ++++ ++ + E+++ ++ KA+
Sbjct: 577 TDLSKSRENLSAV--MLYNPGLE-FERQQREELEKLESKRKLIEEMEEKQKSDKAE---- 629
Query: 1565 QSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624
L+ Q+E++ KE E VQ ++ + + LK + I K+K+
Sbjct: 630 -------------LERMQQEVETQRKETEI---VQLQIRKQEESLKRRSFHIENKLKDLL 673
Query: 1625 EKEYQFLKMTAVNETQEKMCEIEHLKEQ--FETQKLNLE-----NIETENIRLTQILHEN 1677
++ +F E E L+EQ E QK E ++ E RL ++ +
Sbjct: 674 AEKEKF--------------EEERLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNE 719
Query: 1678 LEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHM--HLKEHQE 1735
E + +E D L+ ++ + + K+ L E EK++ + + H+ L+E QE
Sbjct: 720 KAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQ-----EKEQVMLVAHLEEQLREKQE 774
Query: 1736 TIDKLR-----GIVSEKTN----------------------------------------- 1749
I LR + EK +
Sbjct: 775 MIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLV 834
Query: 1750 EISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809
++ N++KDL D LK + + QE L ++ ++K V++ T+ + +K
Sbjct: 835 KLVNLEKDLVQQKDILKKEVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEK 894
Query: 1810 DLENSNAKLQEKIQELK-ANEHQLITLKKDVNETQKKV--------SEMEQLKKQIKDQS 1860
++ +LQ K ++L+ ++ L TL ++ + + + + Q++K+++++
Sbjct: 895 -IKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKE 953
Query: 1861 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETL-----KLERDQLKESLQET 1915
L++ + N N QKL E ++ ++ + +R+ E+ + K +R+ L+ +L
Sbjct: 954 EQLAQYQ-ANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARL 1012
Query: 1916 KARDLEIQQELKTARMLSKEHKETVDKLREKISEKT---IQISDIQKDLDKSKDELQKKI 1972
+ R +Q+ T M +E ++ + L E++ + Q+ L+K ++ L+ +I
Sbjct: 1013 ERRHSALQRH-STLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEI 1071
Query: 1973 QELQKKELQLLRVKED 1988
Q+L++K ++ V++D
Sbjct: 1072 QQLKQKIYEVDGVQKD 1087
Score = 75.9 bits (185), Expect = 5e-13
Identities = 162/745 (21%), Positives = 325/745 (43%), Gaps = 100/745 (13%)
Query: 1586 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE 1645
QI + + ++E LQ +++E TKE K E+Q + + Q
Sbjct: 392 QIALLDSPTALSMEEKLQQNEARVQELTKEWTNKWNETQN----------ILKEQTLALR 441
Query: 1646 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEET----LKVE 1701
E + +++ +L I+ +++ T I+ +L+E ++ RDD + ++ L +E
Sbjct: 442 KEGIGVVLDSELPHLIGID-DDLLSTGIILYHLKEGQTYVG-RDDASTEQDIVLHGLDLE 499
Query: 1702 RDQ-LKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760
+ + EN+ T+T + + + + E +++ I+ +TN H
Sbjct: 500 SEHCIFENIGGTVTLIPLSGSQCSVNGVQIVEATH-LNQGAVILLGRTNMFR-----FNH 553
Query: 1761 SNDALKAQDLK---IQEELRIAHMHLKEQQETIDKLR----GIVSEKTDKLSNMQKDLEN 1813
+A K ++ + + ++ L + +E + + G+ E+ + ++K LE+
Sbjct: 554 PKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFERQQR-EELEK-LES 611
Query: 1814 SNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENL-- 1871
++E ++ K+++ +L ++++V ETQ+K +E+ QL+ + +++SL IEN
Sbjct: 612 KRKLIEEMEEKQKSDKAELERMQQEV-ETQRKETEIVQLQIRKQEESLKRRSFHIENKLK 670
Query: 1872 -NLAQK-------LHENLE-EMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEI 1922
LA+K L E E E++ +E + RV+E L+ +LKE KA +I
Sbjct: 671 DLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQ----RLKELNNNEKAEKFQI 726
Query: 1923 QQELKTARMLSKEHKETVDKL---REKISEKTIQISDIQKDLDKSKDELQKKIQELQKKE 1979
QEL L KE E KL ++++ E+ + + L++ E Q+ IQ L++ E
Sbjct: 727 FQELD---QLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGE 783
Query: 1980 LQ---------------LLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024
+Q LLRVKE + E+E+ + +F + R +L
Sbjct: 784 VQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRF------FEFKRRQLVKLV 837
Query: 2025 KKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLR-------EMIARDRQNHQVKP 2077
+ +++ I+ KE E + I E LK E D+ L ++ + ++KP
Sbjct: 838 NLEKDLVQQKDILKKEVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKP 897
Query: 2078 EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLD-----LEKEIEFQK 2132
+ L ++ L L+ + E +R E+ D LSLD +EKE+E ++
Sbjct: 898 VEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDR----GPLSLDNTLYQVEKEMEEKE 953
Query: 2133 ELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHE-SI 2191
E + +AN + Q + ++ F + + ++ KK K +L K + E E ++
Sbjct: 954 EQLAQYQANAN----QLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERAL 1009
Query: 2192 NKFEMDFIDEVEKQKELLIKIQHLQQ---DCDVPSRELRDLKLNQNMDLHIEEILKDFSE 2248
+ E +++ L ++I+ +Q + SRE L+ + + E ++ E
Sbjct: 1010 ARLERRH-SALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKDQERLE 1068
Query: 2249 SEFPSIKTEFQQVLSNRKEMTQFLE 2273
E +K + +V +K+ LE
Sbjct: 1069 YEIQQLKQKIYEVDGVQKDHHGTLE 1093
Score = 66.2 bits (160), Expect = 4e-10
Identities = 174/816 (21%), Positives = 325/816 (39%), Gaps = 166/816 (20%)
Query: 344 LLKRYRKEIMDLKKQLEEVS--------LETRAQAMEK----DQLAQLLEEKDLLQKVQN 391
LL + + DL K E +S LE Q E+ + +L+EE + QK
Sbjct: 568 LLSSFSLSMTDLSKSRENLSAVMLYNPGLEFERQQREELEKLESKRKLIEEMEEKQKSDK 627
Query: 392 EKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPT---NITT 448
++E + QQE++ +RK L +I K + S F+I ++
Sbjct: 628 AELERM------------QQEVETQRKETEIVQL-QIRKQEESLKRRSFHIENKLKDLLA 674
Query: 449 KTHKLSINLLREIDESVCS----ESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLR 504
+ K LRE E E + F + L + K LN N+ +
Sbjct: 675 EKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQRL------KELN--------NNEK 720
Query: 505 ADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVK 564
A+ + + +QL+ EK+E KL+ LE+K ++QE + + LV
Sbjct: 721 AEKFQIFQELDQLQKEKDEQYAKLE----------LEKKRLEEQEKEQV-------MLVA 763
Query: 565 HAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMK 624
H E E LREK++ I+ L+ + Q +E K DL ES+ K+ +
Sbjct: 764 HLE--------------EQLREKQEMIQLLRRG-EVQWVEEEKRDLEGIRESLLRVKEAR 808
Query: 625 Q-TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ 683
D E + R F R + ++L K+L ++ ++Q Q LE K +
Sbjct: 809 AGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILEC-LKCE 867
Query: 684 VDLEKELQSAFNE-ITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEEN------ 736
D E L +E +T +T +VP+D +E ++ +++L ++ +
Sbjct: 868 HDKESRLLEKHDESVTDVT-----EVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLE 922
Query: 737 EALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL---------FSEVVHK 787
E R IL SL + + ++ KE+++K E+L + ++L + + +
Sbjct: 923 EKQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQLQKLQATFEFTANIARQ 982
Query: 788 ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847
E +V+ +EI ++++ + ++ ++ + H Q++ + E E Q++
Sbjct: 983 EEKVRKKEKEILESRE-----KQQREALERALARLERRHSAL-QRHSTLGMEIEEQRQKL 1036
Query: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLN-EMEQLKEQLENRDSTLQTV 906
+L+ +++ +L+ E QE + QERL E++QLK+++ D +
Sbjct: 1037 ASLNSGSREQSGLQASLEAE--------QEALEKDQERLEYEIQQLKQKIYEVDGVQK-- 1086
Query: 907 EREKTLITEKLQQTLEEVKTLTQEKDDLKQLQES-----LQIERDQLKSDIHDTVNMNID 961
+ TL + +L ++ EK L L ++ ++ E + D+H ++
Sbjct: 1087 DHHGTLEGKVASSSL----PVSAEKSHLVPLMDARINAYIEEEVQRRLQDLHRVISEGCS 1142
Query: 962 TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKM-------VG 1014
T E L H TI K K VSR+L N + KD + + G
Sbjct: 1143 TSADTMKDNEKL--HNGTIQR-KLKYERMVSRSL--GANPDDLKDPIKISIPRYVLCGQG 1197
Query: 1015 IDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLK 1074
D + E K T ++++ +F E+ + L+ AE L+ K
Sbjct: 1198 KDAHFEFEVKIT-----------VLDETWTVFRRYSRFREMHKTLKLKYAELAALEFPPK 1246
Query: 1075 ENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIK 1110
+L G+ K + ++A+ ++H K
Sbjct: 1247 -------------KLFGN---KDERVIAERRSHLEK 1266
Score = 42.0 bits (97), Expect = 0.008
Identities = 91/461 (19%), Positives = 183/461 (39%), Gaps = 74/461 (16%)
Query: 2182 KIKEEQHESINKFEMD--FIDEVE-KQKELLIKIQHLQQDCDVPSRELRDLKLN------ 2232
+ + +Q E + K E I+E+E KQK +++ +QQ+ + +E ++L
Sbjct: 597 EFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEE 656
Query: 2233 --QNMDLHIEEILKDF--SESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNG 2288
+ HIE LKD + +F + QQ + +K+ + E+
Sbjct: 657 SLKRRSFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQE------------EETFLR 704
Query: 2289 IQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT 2348
+Q+E R+ ++NN I E + ++ + E + K L+E+ ++
Sbjct: 705 VQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAH 764
Query: 2349 LKTSLASGAQVNPT--------TQDNKNPHVTSRATQLTTEKIR--------ELENSLHE 2392
L+ L ++ ++ K R + L ++ R ELE +
Sbjct: 765 LEEQLREKQEMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLR 824
Query: 2393 AKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKP 2452
E + K++ ++K+L DI+ K +V E + L E ++ DK + +
Sbjct: 825 FFEFKRRQLVKLVNLEKDLVQQKDILKK---EVQEEQEIL----ECLKCEHDKESRLLEK 877
Query: 2453 YKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLR------RS 2506
+ E + D+ V D EK+K E+ + + Q + LL E R R
Sbjct: 878 HDESVTDVTE--VPQDFEKIKPV-EYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRG 934
Query: 2507 QQAQDTSVISEHTDPQPSNKPLT-CGGGSGIVQNTKA-------LILKSEHIR-LEKEI- 2556
+ D ++ + + + L + +Q +A + + E +R EKEI
Sbjct: 935 PLSLDNTLYQVEKEMEEKEEQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEIL 994
Query: 2557 -SKLKQQNEQL------IKQKNELLSNNQHLSNEVKTWKER 2590
S+ KQQ E L +++++ L + L E++ +++
Sbjct: 995 ESREKQQREALERALARLERRHSALQRHSTLGMEIEEQRQK 1035
Score = 34.3 bits (77), Expect = 1.7
Identities = 45/248 (18%), Positives = 102/248 (41%), Gaps = 29/248 (11%)
Query: 2330 QDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVT-SRATQLTTEKIRELEN 2388
++ L+EK + + +L + S ++ N + NP + R + EK+
Sbjct: 555 KEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFERQQREELEKLESKRK 614
Query: 2389 SLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVAL 2448
+ E +E ++++ +MQ+E+E +Q ++ + + L++ I+
Sbjct: 615 LIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIE-------- 666
Query: 2449 GAKPYKEEIEDLKMKLVKIDLEKMKNAKEFE--KEISATKATVEYQKEVIRLLRENLRRS 2506
+++DL + K + E+++ +E E K+ + + Q+E+ RL + L +
Sbjct: 667 ------NKLKDLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQRL--KELNNN 718
Query: 2507 QQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQL 2566
++A+ + E Q Q K + K EKE L E+
Sbjct: 719 EKAEKFQIFQELDQLQKEKDE----------QYAKLELEKKRLEEQEKEQVMLVAHLEEQ 768
Query: 2567 IKQKNELL 2574
+++K E++
Sbjct: 769 LREKQEMI 776
>gi|4758646 kinesin family member 3B [Homo sapiens]
Length = 747
Score = 288 bits (738), Expect = 4e-77
Identities = 216/622 (34%), Positives = 326/622 (52%), Gaps = 74/622 (11%)
Query: 6 AVAVCVRVRPLNSREESLG---------ETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGN 56
+V V VR RP+N +E++ + QV K +++ K+F FD V+ N
Sbjct: 9 SVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMP--KTFTFDAVYDWN 66
Query: 57 ETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTM---MGSEDHLGVIPRAIHDI 113
+Y+E P++DS +QG+NGTIFAYGQT +GKTYTM G + GVIP + I
Sbjct: 67 AKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHI 126
Query: 114 FQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVY 173
F I + ++++L+R SY+EIY E I DLL Q K L ++E + VYV DL+ V
Sbjct: 127 FTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQ-TKRLELKERPDTGVYVKDLSSFVTK 185
Query: 174 TSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNL 233
+ + + G ++R G T MN+ SSRSH IF + +E E G + E ++V LNL
Sbjct: 186 SVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVG--LDGENHIRVGKLNL 243
Query: 234 VDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQ 293
VDLAGSER A+TGA G RLKE IN SL LG VI L DG+ I YRDSKLTR+LQ
Sbjct: 244 VDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGK-STHIPYRDSKLTRLLQ 302
Query: 294 NSLGGNAKTRIICTITPVSF--DETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKE 351
+SLGGNAKT ++ + P S+ +ETLT L++A+ AK +KN P VNE D ALL+ +++E
Sbjct: 303 DSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKD-ALLREFQEE 361
Query: 352 IMDLKKQLEEVSLETR-----------------AQAMEKDQLAQLLEEKDLLQKVQNEKI 394
I LK QLE+ S+ R + E ++ + ++KD + Q EK+
Sbjct: 362 IARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKL 421
Query: 395 ENLTRMLVTSSSLTLQQELK-----------AKRKRRVTWCLG-KINKMKN------SNY 436
E R +V SL +++++ +R++ LG KI M++ N
Sbjct: 422 EIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNI 481
Query: 437 ADQFNIPTNITTKTHKLSINLL---REIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQ 493
D N I + + REI + + S + +T S ++ K
Sbjct: 482 VDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKL 541
Query: 494 ENIESELNSLRADYDNLVLDYEQLRTEKEE------MELKLKEKNDLDEFEALERKTK-- 545
+ + S+L +++A+ +L ++ + R E E+ ELKLK ++ F LE K+K
Sbjct: 542 KKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHL-IIENFIPLEEKSKIM 600
Query: 546 ------KDQEMQLIHEISNLKN 561
++++ +H I+ L+N
Sbjct: 601 NRAFFDEEEDHWKLHPITRLEN 622
Score = 52.4 bits (124), Expect = 6e-06
Identities = 77/377 (20%), Positives = 162/377 (42%), Gaps = 65/377 (17%)
Query: 852 KEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQL-KEQLENRDSTLQTVER-- 908
KEA K + SL AL +S + K+ + R +++ +L ++ L T+
Sbjct: 263 KEATKINLSLSALGNVISAL---VDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGP 319
Query: 909 -----EKTLITEKLQQTLEEVKTLTQEKDDLKQ-LQESLQIERDQLKSDIHDTVNMNIDT 962
E+TL T + + +K + +D K L Q E +LK+ +
Sbjct: 320 ASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKR 379
Query: 963 QEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEF---QQKMVGIDKKQ 1019
+E+ R S EE E G+ KD++ QQ+ + I+K+
Sbjct: 380 REKRREGGGS------------GGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRA 427
Query: 1020 DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
+E +L A+ K + E+++K+ L +EK+ + + + A + +L K ++
Sbjct: 428 IVE---DHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDH 484
Query: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
T E Q+ L +K+QEI Q++ +E QQ++ +
Sbjct: 485 TNEQQKILE------QKRQEIAEQKRRE----------------------REIQQQMESR 516
Query: 1140 QQQLLNVQEEMSEMQKKIN----EIENLKNELKNKELTLEHMETERLELAQKLNENYEEV 1195
++ L ++E S +Q++++ +++ L ++L+ + + ++ E ++ Q+L + E
Sbjct: 517 DEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNE- 575
Query: 1196 KSITKERKVLKELQKSF 1212
+T+E K+ + ++F
Sbjct: 576 --LTRELKLKHLIIENF 590
Score = 48.9 bits (115), Expect = 7e-05
Identities = 58/309 (18%), Positives = 137/309 (44%), Gaps = 38/309 (12%)
Query: 1734 QETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ------DLKIQEELR-IAHMHLKEQ 1786
+ET+ LR + + I N + E DAL + LK Q E R I +E+
Sbjct: 325 EETLTTLR--YANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREK 382
Query: 1787 QETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELK------ANEHQLITLKKD-- 1838
+ G E+ ++ +++ ++ + +E+ ++L+ +H L+ +K
Sbjct: 383 RREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRL 442
Query: 1839 VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE 1898
+ E +KK+ ++ + K + + +E + L + + ++ E + +++++
Sbjct: 443 LKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQK------- 495
Query: 1899 ETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQ 1958
++ + E K R+ EIQQ++++ + E KET L++++ KT ++ +
Sbjct: 496 ----------RQEIAEQKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLF 545
Query: 1959 KDLDKSKDEL----QKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ 2014
L K E+ ++ I+E Q+ E + ++ + H I L+++ + N +
Sbjct: 546 SKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLIIENFIPLEEKSKIMNRAFF 605
Query: 2015 SVRMDNFQL 2023
D+++L
Sbjct: 606 DEEEDHWKL 614
Score = 48.5 bits (114), Expect = 9e-05
Identities = 69/319 (21%), Positives = 141/319 (44%), Gaps = 47/319 (14%)
Query: 1088 RLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ 1147
RLL D L + V E + T R A + +K K + ++ + LL
Sbjct: 299 RLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREF 358
Query: 1148 EEMSEMQKKINEIENLKNELKNKELTLEHMETERLELA-------QKLNENYEEVKSITK 1200
+E EI LK +L+ + + +R E ++ E E +
Sbjct: 359 QE---------EIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDD 409
Query: 1201 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
+ +E Q+ E E+ + +E L +E++++ LKE ++ +++LRR E
Sbjct: 410 KDDYWREQQEKLEIEKRAI------VEDHSLVAEEKMRL----LKEKEKKMEDLRR---E 456
Query: 1261 KTAQIINTQDLEKSHTKL----QEEIPVLHEEQELLPNVK-EVSETQETMNELELLTEQS 1315
K A + ++ +KL + + +E+Q++L + E++E + E++ +Q
Sbjct: 457 KDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQ---QQM 513
Query: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK-HDQLKEHIRE 1374
++D TL L E + Q+E+ TK+ L + +A++ + HD +EHI+E
Sbjct: 514 ESRDEETL--------ELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKE 565
Query: 1375 TLAKIQESQSKQEQSLNMK 1393
+++++Q++ + L +K
Sbjct: 566 R-QELEQTQNELTRELKLK 583
Score = 44.7 bits (104), Expect = 0.001
Identities = 66/312 (21%), Positives = 142/312 (45%), Gaps = 33/312 (10%)
Query: 1487 KEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEK 1546
+E+EE E +K+ Q++LE + I E + + ++ + E ++K
Sbjct: 394 EEEEEEGEEGEEEGDDKDDYWREQQEKLEIE----KRAIVEDHSLVAEEKMRLLKEKEKK 449
Query: 1547 VNELKQFKEHRKAKDSALQSIESKML-------ELTNR----LQESQEEIQIMIKEKEEM 1595
+ +L++ K+ + + ++++ESK+L + TN L++ ++EI + + E+
Sbjct: 450 MEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREI 509
Query: 1596 KRVQEALQIERDQLKENTKEIVAKMK-ESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE 1654
++ E+ E +LKE + ++ ++++ + F K+ AV + E EH+KE+ E
Sbjct: 510 QQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQE-EHIKERQE 568
Query: 1655 TQKLNLENIETENIRLTQILHEN---LEEM-----RSVTKERDDLRSVEETLKVERDQLK 1706
++ +N T ++L ++ EN LEE R+ E +D + ++E Q+
Sbjct: 569 LEQ--TQNELTRELKLKHLIIENFIPLEEKSKIMNRAFFDEEEDHWKLHPITRLENQQM- 625
Query: 1707 ENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALK 1766
++ ++ K+ + M + E + IV + + S +D E A K
Sbjct: 626 --MKRPVSAVGYKRPLSQHARMSMMIRPEARYRAENIVLLELDMPSRTTRDYEGPAIAPK 683
Query: 1767 AQ---DLKIQEE 1775
Q D +Q+E
Sbjct: 684 VQAALDAALQDE 695
Score = 44.7 bits (104), Expect = 0.001
Identities = 45/203 (22%), Positives = 93/203 (45%), Gaps = 30/203 (14%)
Query: 1431 QESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH-LETEEELKVAHCCLKEQ 1489
+E +E + +KDD R Q+ ++L+ + IV H L EE++++ LKE+
Sbjct: 397 EEEGEEGEEEGDDKDDYWREQQ------EKLEIEKRAIVEDHSLVAEEKMRL----LKEK 446
Query: 1490 EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNE 1549
E+ + +LR ++ + +++A+ KL + I + + Q +++K E
Sbjct: 447 EKKMEDLR----REKDAAEMLGAKIKAMESKLLVGGKNIVDHTNE----QQKILEQKRQE 498
Query: 1550 LKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKE-----------KEEMKRV 1598
+ + K + ++S + + LEL Q+E+ I K+ K E+ +
Sbjct: 499 IAEQKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDL 558
Query: 1599 QEALQIERDQLKENTKEIVAKMK 1621
QE ER +L++ E+ ++K
Sbjct: 559 QEEHIKERQELEQTQNELTRELK 581
Score = 41.6 bits (96), Expect = 0.011
Identities = 34/172 (19%), Positives = 85/172 (49%), Gaps = 22/172 (12%)
Query: 796 EEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQ 855
EE G KDD Q + + E + H ++ +L+E E+ +++ A+
Sbjct: 404 EEEGDDKDDYWREQQ--EKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAE 461
Query: 856 KFDSSLGALKTEL-----------SYKTQELQEKTREVQERLNEMEQLKEQLENRD---- 900
+ + A++++L + + + L++K +E+ E+ ++++Q+E+RD
Sbjct: 462 MLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETL 521
Query: 901 ---STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQ--LQESLQIERDQ 947
T ++++E + T+KL++ +++ + E DL++ ++E ++E+ Q
Sbjct: 522 ELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQ 573
Score = 39.3 bits (90), Expect = 0.053
Identities = 39/164 (23%), Positives = 74/164 (45%), Gaps = 9/164 (5%)
Query: 652 KEKMKELATTYKQMENDIQLYQSQ----LEAKKKMQVDLEKELQSAFNEITKLTSLIDGK 707
+E+ ++L + + D L + L+ K+K DL +E +A L + I
Sbjct: 415 REQQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAA----EMLGAKIKAM 470
Query: 708 VPKDLLCNLELEGKITDLQKELNKEVEE-NEALREEVILLSELKSLPSEVERLRKEIQDK 766
K L+ + + QK L ++ +E E R E + +++S E L++
Sbjct: 471 ESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYSSL 530
Query: 767 SEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQS 810
+E+ I T + KLFS++ ++ + L EE K + +L TQ+
Sbjct: 531 QQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQN 574
Score = 37.0 bits (84), Expect = 0.26
Identities = 92/520 (17%), Positives = 209/520 (40%), Gaps = 75/520 (14%)
Query: 1741 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKI-QEELR-------IAHMHLKEQQET--- 1789
RG++ + I ++ ++A L+I QEE+R + LKE+ +T
Sbjct: 116 RGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVY 175
Query: 1790 IDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET------- 1842
+ L V++ ++ ++ + + + E + H + + + +E
Sbjct: 176 VKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENH 235
Query: 1843 ----QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE 1898
+ + ++ ++Q K + E +NL+ N+ K R
Sbjct: 236 IRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDS 295
Query: 1899 ETLKLERDQLKESLQETKARDL-----EIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
+ +L +D L + + ++ +++ L T R ++ K +K R K
Sbjct: 296 KLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRA-KNIKNKPRVNEDPKDAL 354
Query: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSM 2013
+ + Q+++ + K +L+K+ +K+ + ++ E E+ +++ + ++
Sbjct: 355 LREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYW 414
Query: 2014 QSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNH 2073
+ + + ++ K+ +E+ +VA+E+ +R +KE K D RE A +
Sbjct: 415 RE-QQEKLEIEKRA--IVEDHSLVAEEK--MRLLKEKEKKMED----LRREKDAAEMLGA 465
Query: 2074 QVKP-EKRLLSDGQQ---HLTES---LREKCSRIKELLKRYSEMDDHYECLNRLSLDLEK 2126
++K E +LL G+ H E L +K I E +R E+ E + +L+L++
Sbjct: 466 KIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKE 525
Query: 2127 EIE-FQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185
Q+E+ ++ TK ++KLF+ Q E H + ++ IKE
Sbjct: 526 TYSSLQQEVDIK-----------TKKLKKLFSKLQAVKAEIHDLQEE---------HIKE 565
Query: 2186 EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRE 2225
Q +++ + + +K++HL + +P E
Sbjct: 566 RQE----------LEQTQNELTRELKLKHLIIENFIPLEE 595
Score = 34.7 bits (78), Expect = 1.3
Identities = 43/190 (22%), Positives = 87/190 (45%), Gaps = 17/190 (8%)
Query: 520 EKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSS 579
E+EE E +E +D D++ E++ K + E + I E +L K L E
Sbjct: 396 EEEEGEEGEEEGDDKDDYWR-EQQEKLEIEKRAIVEDHSLVAEEK------MRLLKEKEK 448
Query: 580 KVELLREKEDQIKKLQEYI---DSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALD 636
K+E LR ++D + L I +S+ L K + ++ E + +Q +Q + + + +
Sbjct: 449 KMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRRERE 508
Query: 637 AKRESAFLRSENLELKEKMKEL-------ATTYKQMENDIQLYQSQLEAKKKMQVDLEKE 689
+++ E LELKE L K++ + +Q ++++ ++ + +E
Sbjct: 509 IQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQE 568
Query: 690 LQSAFNEITK 699
L+ NE+T+
Sbjct: 569 LEQTQNELTR 578
Score = 33.5 bits (75), Expect = 2.9
Identities = 51/228 (22%), Positives = 96/228 (42%), Gaps = 30/228 (13%)
Query: 1325 RIEMERLRLNEKFQESQEEIKSLTKERD----NLKTIKEALEVKHDQLKEHIRETLAKIQ 1380
++E+E+ + E EE L KE++ +L+ K+A E+ AKI+
Sbjct: 420 KLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLG-----------AKIK 468
Query: 1381 ESQSKQ-EQSLNMKEKDNETTKIVSEMEQFKPKDSALLR-IEIEMLGLSKRLQESHDEMK 1438
+SK N+ + NE KI+ + Q + R I+ +M + E +
Sbjct: 469 AMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYS 528
Query: 1439 SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRV 1498
S+ +E D + + L S+ +K I ++ +H++ +EL E+T NEL
Sbjct: 529 SLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQEL----------EQTQNELTR 578
Query: 1499 NLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEK 1546
L K I E K+ N+ E+E+ + + I+ ++ +
Sbjct: 579 ELKLKHLIIENFIPLEE--KSKIMNR-AFFDEEEDHWKLHPITRLENQ 623
>gi|46852174 kinesin family member 3A [Homo sapiens]
Length = 699
Score = 288 bits (737), Expect = 5e-77
Identities = 227/623 (36%), Positives = 336/623 (53%), Gaps = 54/623 (8%)
Query: 7 VAVCVRVRPLNSREESL--GETAQVYWKTDNNVIYQVDGS----KSFNFDRVFHGNETTK 60
V V VR RPLN RE+S+ + V +++ D S K+F FD VF
Sbjct: 15 VKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQL 74
Query: 61 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSE---DHLGVIPRAIHDIFQKI 117
+VY A PIIDS ++GYNGTIFAYGQT +GKT+TM G + G+IP + IF I
Sbjct: 75 DVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFGHI 134
Query: 118 KKFP-DREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSE 176
K D FL+RVSY+EIYNE + DLL G + + L ++E + VY+ DL+ VV ++
Sbjct: 135 AKAEGDTRFLVRVSYLEIYNEEVRDLL-GKDQTQRLEVKERPDVGVYIKDLSAYVVNNAD 193
Query: 177 MALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDL 236
+ +T G K+R G T MN+ SSRSH IF + +E EKG N V++ L+LVDL
Sbjct: 194 DMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMH--VRMGKLHLVDL 251
Query: 237 AGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSL 296
AGSER A+TGA G RLKE IN SL LG VI L DG+ + YR+SKLTR+LQ+SL
Sbjct: 252 AGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGK-STHVPYRNSKLTRLLQDSL 310
Query: 297 GGNAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMD 354
GGN+KT + I P ++DET++ L++A+ AK +KN +NE D ALL++++KEI +
Sbjct: 311 GGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKD-ALLRQFQKEIEE 369
Query: 355 LKKQL---EEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQ 411
LKK+L EE+S + + E D EE ++ + + K + + + +Q
Sbjct: 370 LKKKLEEGEEISGSDISGSEEDDD-----EEGEVGEDGEKRKKRRGKKKVSPDKMIEMQA 424
Query: 412 ELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDV 471
++ +RK T L + +N A+ ++ K + +LL ++ E V
Sbjct: 425 KIDEERKALET-KLDMEEEERNKARAELEKREKDL-LKAQQEHQSLLEKLS---ALEKKV 479
Query: 472 FSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEK 531
+D L++ E KLL + N+E E RA EQLR E EE E +E+
Sbjct: 480 IVGGVDLLAKAE--EQEKLLEESNMELEERRKRA---------EQLRRELEEKE---QER 525
Query: 532 NDLDE-----FEALERKTKKDQEM--QLIHEISNLKNLVKHAEVYNQDLENELSSKVELL 584
D++E E + KTKK +++ L+ S + +L + + +++E L + +L
Sbjct: 526 LDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADL---QQEHQREIEGLLENIRQLS 582
Query: 585 REKEDQIKKLQEYIDSQKLENIK 607
RE Q+ + +I E I+
Sbjct: 583 RELRLQMLIIDNFIPRDYQEMIE 605
Score = 55.5 bits (132), Expect = 7e-07
Identities = 80/314 (25%), Positives = 146/314 (46%), Gaps = 64/314 (20%)
Query: 951 DIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQ 1010
+I + +N D ++ L L+Q Q+ I LK K+ E + + +G +D+ ++
Sbjct: 344 NIKNKARINEDPKDAL------LRQFQKEIEELKKKLEE--GEEISGSDISGSEEDDDEE 395
Query: 1011 KMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLK 1070
VG D ++ + + + ++ D ++IE Q KI +E+ L+ L+ E+ + +
Sbjct: 396 GEVGEDGEKRKKRRGKKKVSPD----KMIEMQAKID---EERKALETKLDMEEEERNKAR 448
Query: 1071 TDLKENIEMTIENQEELRLLGDELKKQQEIVAQ-EKNHAIKKEGELSRTCDRLAEVEEKL 1129
+L E +E+ D LK QQE + EK A++K+ + D LA+ EE
Sbjct: 449 AEL--------EKREK-----DLLKAQQEHQSLLEKLSALEKKVIVGGV-DLLAKAEE-- 492
Query: 1130 KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLN 1189
Q++LL +E E++++ E L+ EL+ KE ERL++ +K
Sbjct: 493 ----------QEKLL--EESNMELEERRKRAEQLRRELEEKE-------QERLDIEEKYT 533
Query: 1190 ENYEEVKSITKE-RKVLKELQKSFETERDHLRGYIREIEATGL-----QTKEELKIAHIH 1243
EE + TK+ +KV L + D + + REIE GL Q EL++ +
Sbjct: 534 SLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIE--GLLENIRQLSRELRLQMLI 591
Query: 1244 L-----KEHQETID 1252
+ +++QE I+
Sbjct: 592 IDNFIPRDYQEMIE 605
Score = 55.5 bits (132), Expect = 7e-07
Identities = 60/266 (22%), Positives = 127/266 (47%), Gaps = 28/266 (10%)
Query: 1494 NELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQF 1553
N+ R+N K+ + QK++E + KL+ E+ +I E ++ E+ +
Sbjct: 347 NKARINEDPKDALLRQFQKEIEELKKKLEEG-----EEISGSDISGSEEDDDEEGEVGED 401
Query: 1554 KEHRKAKDSALQSIESKMLELTNRLQESQE--EIQIMIKEKEEMKRVQEALQIERDQLK- 1610
E RK + + KM+E+ ++ E ++ E ++ ++E+E K E + E+D LK
Sbjct: 402 GEKRKKRRGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKA 461
Query: 1611 -ENTKEIVAKMKESQEKE-YQFLKMTAVNETQEKM-----CEIEHLKEQFETQKLNLENI 1663
+ + ++ K+ ++K + + A E QEK+ E+E +++ E + LE
Sbjct: 462 QQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEK 521
Query: 1664 ETENIRLTQILHENLEEMRSVTKE-----------RDDLRSVEETLKVERDQLKENLRET 1712
E E + + + EE + TK+ + ++ +++ + E + L EN+R+
Sbjct: 522 EQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQ- 580
Query: 1713 ITRDLEKQEELKIVHMHLKEHQETID 1738
++R+L Q L I + +++QE I+
Sbjct: 581 LSRELRLQ-MLIIDNFIPRDYQEMIE 605
Score = 50.1 bits (118), Expect = 3e-05
Identities = 75/330 (22%), Positives = 131/330 (39%), Gaps = 44/330 (13%)
Query: 749 LKSLPSEVERLRKEIQDKSE--ELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLA 806
L+ E+E L+K++++ E I SE+D V ++ + + GK K
Sbjct: 360 LRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRK--KRRGKKKVSPD 417
Query: 807 TTQSNYKSTDQEFQNFKT-LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK 865
D+E + +T L M+ E++ K E E+ ++++ +E Q L AL+
Sbjct: 418 KMIEMQAKIDEERKALETKLDMEEEERNK-ARAELEKREKDLLKAQQEHQSLLEKLSALE 476
Query: 866 -------TELSYKTQE----LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT 914
+L K +E L+E E++ER EQL+ +LE ++ +E + T +
Sbjct: 477 KKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQ 536
Query: 915 EKLQQTLEEVK----TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNAL 970
E+ Q +++K L K ++ LQ+ Q E + L E +R
Sbjct: 537 EEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGL--------------LENIRQLS 582
Query: 971 ESLKQHQETI-NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL 1029
L+ I N + E + +H E+ G E+Q K V QT
Sbjct: 583 RELRLQMLIIDNFIPRDYQEMIENYVHWNEDIG----EWQLKCVAYTGNN----MRKQTP 634
Query: 1030 TADVKDNEIIEQQRKIFSLIQEKNELQQML 1059
D K+ + E L + L+Q L
Sbjct: 635 VPDKKEKDPFEVDLSHVYLAYTEESLRQSL 664
Score = 48.5 bits (114), Expect = 9e-05
Identities = 58/268 (21%), Positives = 118/268 (44%), Gaps = 39/268 (14%)
Query: 1342 EEIKSLTKERDNLKTIKEALEVKHD-------QLKEHIRETLAKIQESQSKQEQSLNMKE 1394
+E S + + K IK + D Q ++ I E K++E + ++ E
Sbjct: 330 DETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSE 389
Query: 1395 KDNETTKIVSEMEQFKPK---------DSAL---LRIEIEMLGLSKRLQESHDEMKS--- 1439
+D++ V E + + K D + +I+ E L +L +E
Sbjct: 390 EDDDEEGEVGEDGEKRKKRRGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARA 449
Query: 1440 -VAKEKDDLQRLQEVLQSESDQLKENIKEIV-------AKHLETEEELKVAHCCLKEQEE 1491
+ K + DL + Q+ QS ++L K+++ AK E E+ L+ ++ L+E+ +
Sbjct: 450 ELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRK 509
Query: 1492 TINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELK 1551
+LR L EKE E I+++ ++ ++ Q K +++ + + + ++ +L+
Sbjct: 510 RAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKV-----WTMLMAAKSEMADLQ 564
Query: 1552 QFKEHRKAKDSALQSIESKMLELTNRLQ 1579
Q EH++ + L++I EL RLQ
Sbjct: 565 Q--EHQREIEGLLENIRQLSREL--RLQ 588
Score = 48.1 bits (113), Expect = 1e-04
Identities = 53/273 (19%), Positives = 118/273 (43%), Gaps = 33/273 (12%)
Query: 1738 DKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIV 1797
D ++ + EI ++K LE + + D+ EE + E E K RG
Sbjct: 354 DPKDALLRQFQKEIEELKKKLEEGEE-ISGSDISGSEEDDDEEGEVGEDGEKRKKRRGKK 412
Query: 1798 SEKTDKLSNMQKDLENSNAKLQEKIQ-----------ELKANEHQLITLKKDVNETQKKV 1846
DK+ MQ ++ L+ K+ EL+ E L+ K E Q +
Sbjct: 413 KVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLL---KAQQEHQSLL 469
Query: 1847 SEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD 1906
++ L+K++ + L L A++ + LEE ++ER + +
Sbjct: 470 EKLSALEKKVIVGGVDL-------LAKAEEQEKLLEESNMELEER----------RKRAE 512
Query: 1907 QLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKD 1966
QL+ L+E + L+I+++ + + ++ + + K+ + +++D+Q++ + +
Sbjct: 513 QLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIE 572
Query: 1967 ELQKKIQELQKK-ELQLLRVKEDVNMSHKKINE 1998
L + I++L ++ LQ+L + + ++++ E
Sbjct: 573 GLLENIRQLSRELRLQMLIIDNFIPRDYQEMIE 605
Score = 47.4 bits (111), Expect = 2e-04
Identities = 74/300 (24%), Positives = 121/300 (40%), Gaps = 47/300 (15%)
Query: 1121 RLAEVEEKLKEKSQQLQEKQQQLLN-VQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179
R A + +K K++ ++ + LL Q+E+ E++KK+ E E + + + E
Sbjct: 337 RYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEG 396
Query: 1180 ERLELAQKLNENYEEVK-----------SITKERKVLKELQKSFETERDHLRGYIREIEA 1228
E E +K + + K I +ERK L+ E ER+ R + + E
Sbjct: 397 EVGEDGEKRKKRRGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREK 456
Query: 1229 TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE 1288
L+ ++E HQ +++L S EK + L K+ EE
Sbjct: 457 DLLKAQQE----------HQSLLEKL--SALEKKVIVGGVDLLAKA------------EE 492
Query: 1289 QELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLT 1348
QE L + E +E E L + K E ERL + EK+ QEE + T
Sbjct: 493 QEKLLEESNM-ELEERRKRAEQLRRELEEK--------EQERLDIEEKYTSLQEEAQGKT 543
Query: 1349 KERDNLKTIKEALEVK-HDQLKEHIRETLAKIQE-SQSKQEQSLNMKEKDNETTKIVSEM 1406
K+ + T+ A + + D +EH RE ++ Q +E L M DN + EM
Sbjct: 544 KKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRDYQEM 603
Score = 46.6 bits (109), Expect = 3e-04
Identities = 56/262 (21%), Positives = 117/262 (44%), Gaps = 22/262 (8%)
Query: 1676 ENLEEMRSVTKERDD--LRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEH 1733
+N++ + ++ D LR ++ ++ + +L+E E D+ EE + E
Sbjct: 343 KNIKNKARINEDPKDALLRQFQKEIEELKKKLEEG-EEISGSDISGSEEDDDEEGEVGED 401
Query: 1734 QETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKL 1793
E K RG +++ MQ ++ AL+ + +EE A L+++++ + K
Sbjct: 402 GEKRKKRRGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKA 461
Query: 1794 RGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK 1853
+ +KLS ++K + L K +E Q L++ E +++ EQL+
Sbjct: 462 QQEHQSLLEKLSALEKKVIVGGVDLLAKAEE------QEKLLEESNMELEERRKRAEQLR 515
Query: 1854 KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913
++++++ E E L++ +K EE + K+ L++V L + ++ + Q
Sbjct: 516 RELEEK-------EQERLDIEEKYTSLQEEAQGKTKK---LKKVWTMLMAAKSEMADLQQ 565
Query: 1914 ETKARDLEIQQELKTARMLSKE 1935
E EI+ L+ R LS+E
Sbjct: 566 E---HQREIEGLLENIRQLSRE 584
Score = 45.1 bits (105), Expect = 0.001
Identities = 58/270 (21%), Positives = 126/270 (46%), Gaps = 29/270 (10%)
Query: 1869 ENLNLAQKLHENLEE--MKSVMKERDNLRR-VEETLKLERDQLKESLQETKARDLEIQQE 1925
+N+ +++E+ ++ ++ KE + L++ +EE ++ + S +E + E+ ++
Sbjct: 343 KNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGS-EEDDDEEGEVGED 401
Query: 1926 LKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRV 1985
+ + + K + DK+ E ++ + ++ LD ++E K EL+K+E LL+
Sbjct: 402 GEKRKKRRGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKA 461
Query: 1986 KEDVNMSHKKINEM---------------EQLKKQFEAQNLSMQSVRMDNFQLTKKLHES 2030
+++ +K++ + E+ +K E N+ ++ R QL ++L E
Sbjct: 462 QQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEK 521
Query: 2031 LEEIRIVAKER-----DELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDG 2085
E+ R+ +E+ +E + + LK +A EM A +Q HQ + E L +
Sbjct: 522 -EQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEM-ADLQQEHQREIEG--LLEN 577
Query: 2086 QQHLTESLREKCSRIKELLKR-YSEMDDHY 2114
+ L+ LR + I + R Y EM ++Y
Sbjct: 578 IRQLSRELRLQMLIIDNFIPRDYQEMIENY 607
Score = 33.1 bits (74), Expect = 3.8
Identities = 54/269 (20%), Positives = 114/269 (42%), Gaps = 34/269 (12%)
Query: 477 DTLSEIEW-NPATKLLNQENI-ESELNSLRADYDNLVLDYEQLRTEKEEM---ELKLKEK 531
+T+S + + N A + N+ I E ++L + + + ++ E EE+ ++ E+
Sbjct: 331 ETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEE 390
Query: 532 NDLDEFEALE-------RKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKV--E 582
+D +E E E R+ KK + E+ + + A D+E E +K E
Sbjct: 391 DDDEEGEVGEDGEKRKKRRGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAE 450
Query: 583 LLREKEDQIKKLQEYIDS-QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRES 641
L + ++D +K QE+ +KL ++ + + + ++ L + + L+ +R+
Sbjct: 451 LEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKR 510
Query: 642 AFL--------RSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDL----EKE 689
A E L+++EK L + ++ + L A K DL ++E
Sbjct: 511 AEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQRE 570
Query: 690 LQSAFNEITKLTS-------LIDGKVPKD 711
++ I +L+ +ID +P+D
Sbjct: 571 IEGLLENIRQLSRELRLQMLIIDNFIPRD 599
>gi|30794488 kinesin family member 27 [Homo sapiens]
Length = 1401
Score = 288 bits (737), Expect = 5e-77
Identities = 318/1346 (23%), Positives = 597/1346 (44%), Gaps = 191/1346 (14%)
Query: 3 EEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNV 62
EE V V VR+RPL +E V ++ + + + F FD VF N T V
Sbjct: 2 EEIPVKVAVRIRPLLCKEALHNHQVCVRVIPNSQQVI-IGRDRVFTFDFVFGKNSTQDEV 60
Query: 63 YEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGS------EDHLGVIPRAIHDIFQK 116
Y P++ S I+GYN T+FAYGQT SGKTYT+ G E G+IPRAI +IFQ
Sbjct: 61 YNTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGGHIASVVEGQKGIIPRAIQEIFQS 120
Query: 117 IKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSE 176
I + P +F ++VSY+E+Y E + DLL MK L IRED N + E V ++
Sbjct: 121 ISEHPSIDFNVKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECHVESAG 180
Query: 177 MALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVK-----VSHL 231
+ + G +RH G T+MN+ SSRSH IF + + K + +GS VS
Sbjct: 181 EVMSLLEMGNAARHTGTTQMNEHSSRSHAIFTISICQVHKNMEAAEDGSWYSPRHIVSKF 240
Query: 232 NLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSD-GQVGGFINYRDSKLTR 290
+ VDLAGSER +TG G R KE IN L LG VI L D + I YRD+K+TR
Sbjct: 241 HFVDLAGSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITR 300
Query: 291 ILQNSLGGNAKTRIICTITPVS--FDETLTALQFASTAKYMKNTPYVN------EVSTDE 342
+L++SLGG+AKT +I ++P S FDE+L +L++A+ A+ ++N P VN + E
Sbjct: 301 LLKDSLGGSAKTVMITCVSPSSSNFDESLNSLKYANRARNIRNKPTVNFSPESDRIDEME 360
Query: 343 ALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLV 402
+K R+ + + + + + R + + +++ L E+ LQ E L
Sbjct: 361 FEIKLLREALQSQQAGVSQTTQINREGSPDTNRIHSLEEQVAQLQG------ECLGYQCC 414
Query: 403 TSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREID 462
+ T +LK ++N+ + + F N+++E+
Sbjct: 415 VEEAFTFLVDLKD---------TVRLNEKQQHKLQEWF---------------NMIQEVR 450
Query: 463 ESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKE 522
++V + T + +E P + Q ++ EL + VL +++ ++
Sbjct: 451 KAVLTSFRGIGGT----ASLEEGPQHVTVLQ--LKRELKKCQC-----VLAADEVVFNQK 499
Query: 523 EMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVE 582
E+E+ K K+Q ++ E +K A+ N+ L+NE + +
Sbjct: 500 ELEV----------------KELKNQVQMMVQENKGHAVSLKEAQKVNR-LQNEKIIEQQ 542
Query: 583 LLREK-EDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTL-FDAET---VALDA 637
LL ++ +++ KL + S EN + P++ T+ FD + + +
Sbjct: 543 LLVDQLSEELTKLNLSVTSSAKENCGDGPDARI-----PERRPYTVPFDTHLGHYIYIPS 597
Query: 638 KRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKM--------QVDLEKE 689
+++ S + M L + Q+ +E + K+ D E E
Sbjct: 598 RQD-----SRKVHTSPPMYSLDRIFAGFRTRSQMLLGHIEEQDKVLHCQFSDNSDDEESE 652
Query: 690 LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSEL 749
Q + S I D +C+L +++D Q E K ENE L+ + + S+
Sbjct: 653 GQEKSGTRCRSRSWIQ---KPDSVCSLV---ELSDTQDETQKSDLENEDLKIDCLQESQE 706
Query: 750 KSLP--SEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEE----IGKTKD 803
+L ER+ E + K EL I K+ L E++ + + + ++ + K +
Sbjct: 707 LNLQKLKNSERILTEAKQKMRELTINIKMKEDLIKELIKTGNDAKSVSKQYSLKVTKLEH 766
Query: 804 DLATTQSNYKSTDQEFQNFKTLHM-DFEQKYKMVLEENERMN--QEIVNLSKEAQKFDSS 860
D + T ++ Q + + D K K+ E ++M+ + V + ++ Q+
Sbjct: 767 DAEQAKVELIETQKQLQELENKDLSDVAMKVKLQKEFRKKMDAAKLRVQVLQKKQQDSKK 826
Query: 861 LGALKTELSYKTQELQEKTREVQ-ERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ 919
L +L + + EL++ ++ +++ +L+E+ E R ++R+ QQ
Sbjct: 827 LASLSIQNEKRANELEQSVDHMKYQKIQLQRKLREENEKRKQLDAVIKRD--------QQ 878
Query: 920 TLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979
++E++ T +++ LK E L D N+ ++ + + S+ H +
Sbjct: 879 KIKEIQLKTGQEEGLKPKAEDL------------DACNL-----KRRKGSFGSI-DHLQK 920
Query: 980 INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDL-----EAKNTQTLTADVK 1034
++ K + EEV + L+ + E + + +++ + KK+ L +N + ++
Sbjct: 921 LDEQKKWLDEEVEKVLNQRQELEELEADLKKREAIVSKKEALLQEKSHLENKKLRSSQAL 980
Query: 1035 DNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL---RLLG 1091
+ + ++ ++ L QE +E L++ AE+ KT + E +E+ + +++L R
Sbjct: 981 NTDSLKISTRLNLLEQELSEKNVQLQTSTAEE---KTKISEQVEVLQKEKDQLQKRRHNV 1037
Query: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQL-------- 1143
DE K +++ E+ H L + + + +E ++ +++ +Q +Q+ L
Sbjct: 1038 DEKLKNGRVLSPEEEHV------LFQLEEGIEALEAAIEYRNESIQNRQKSLRASFHNLS 1091
Query: 1144 ---LNVQEEMSEMQ---------KKINEIENLKNELKNKELTLEHMETERLE---LAQKL 1188
NV E+++ + + N++ NL+ + ++L E M+ + LE + ++L
Sbjct: 1092 RGEANVLEKLACLSPVEIRTILFRYFNKVVNLREAERKQQLYNEEMKMKVLERDNMVREL 1151
Query: 1189 NENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQT-----KEELKIAHIH 1243
+ +K R L+ QK E + L + +E + G+ +++++
Sbjct: 1152 ESALDHLKLQCDRRLTLQ--QKEHEQKMQLLLHHFKEQDGEGIMETFKTYEDKIQQLEKD 1209
Query: 1244 LKEHQETIDELRRSVSEKTAQIINTQ 1269
L +++T + ++ + E + I Q
Sbjct: 1210 LYFYKKTSRDHKKKLKELVGEAIRRQ 1235
Score = 112 bits (281), Expect = 4e-24
Identities = 190/954 (19%), Positives = 384/954 (40%), Gaps = 122/954 (12%)
Query: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ---QQLLNVQE 1148
DE + + +N K S DR+ E+E ++K + LQ +Q Q +
Sbjct: 326 DESLNSLKYANRARNIRNKPTVNFSPESDRIDEMEFEIKLLREALQSQQAGVSQTTQINR 385
Query: 1149 EMSEMQKKINEIE----NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKV 1204
E S +I+ +E L+ E + +E T ++L + N ++ + + +
Sbjct: 386 EGSPDTNRIHSLEEQVAQLQGECLGYQCCVEEAFTFLVDLKDTVRLNEKQQHKLQEWFNM 445
Query: 1205 LKELQKSFETERDHLRGYIREIE----ATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
++E++K+ T + G E T LQ K ELK L + ++ V E
Sbjct: 446 IQEVRKAVLTSFRGIGGTASLEEGPQHVTVLQLKRELKKCQCVLAADEVVFNQKELEVKE 505
Query: 1261 KTAQIINTQDLEKSHTKLQEEIPVLH--EEQELLPNVKEVSETQETMNELELLTEQSTTK 1318
Q+ K H +E ++ + ++++ V + E + +L L S +
Sbjct: 506 LKNQVQMMVQENKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSEELTKLNLSVTSSAKE 565
Query: 1319 D--STTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKT-----------IKEALEVKH 1365
+ ARI ER F + +D+ K I +
Sbjct: 566 NCGDGPDARIP-ERRPYTVPFDTHLGHYIYIPSRQDSRKVHTSPPMYSLDRIFAGFRTRS 624
Query: 1366 DQLKEHIRE--TLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423
L HI E + Q S + ++ +EK + S ++ KP DS +E
Sbjct: 625 QMLLGHIEEQDKVLHCQFSDNSDDEESEGQEKSGTRCRSRSWIQ--KP-DSVCSLVE--- 678
Query: 1424 LGLSKRLQESHDEMKSVAKEKDDLQ--RLQEVLQSESDQLKEN---IKEIVAKHLETEEE 1478
L ++ DE + E +DL+ LQE + +LK + + E K E
Sbjct: 679 ------LSDTQDETQKSDLENEDLKIDCLQESQELNLQKLKNSERILTEAKQKMRELTIN 732
Query: 1479 LKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIK 1538
+K+ +KE +T N+ + + +++ ++ E +L +++ E E K
Sbjct: 733 IKMKEDLIKELIKTGNDAKSVSKQYSLKVTKLEHDAEQAKVELIETQKQLQELEN----K 788
Query: 1539 QISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRV 1598
+S+V KV K+F++ A +Q ++ K Q+S++ + I+ ++ +
Sbjct: 789 DLSDVAMKVKLQKEFRKKMDAAKLRVQVLQKKQ-------QDSKKLASLSIQNEKRANEL 841
Query: 1599 QEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKL 1658
++++ D +K ++ K++E EK Q + Q+K+ EI+ Q E K
Sbjct: 842 EQSV----DHMKYQKIQLQRKLREENEKRKQL--DAVIKRDQQKIKEIQLKTGQEEGLKP 895
Query: 1659 NLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLE 1718
E+++ N++ + + S++ K+ D+ K+ L E + + L
Sbjct: 896 KAEDLDACNLK----------------RRKGSFGSIDHLQKL--DEQKKWLDEEVEKVLN 937
Query: 1719 KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRI 1778
+++EL+ + LK+ + + K ++ EK S+++ S+ AL LKI L +
Sbjct: 938 QRQELEELEADLKKREAIVSKKEALLQEK----SHLENKKLRSSQALNTDSLKISTRLNL 993
Query: 1779 AHMHLKEQ----QETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKA----NEH 1830
L E+ Q + + + +SE+ + L + L+ + EK++ + EH
Sbjct: 994 LEQELSEKNVQLQTSTAEEKTKISEQVEVLQKEKDQLQKRRHNVDEKLKNGRVLSPEEEH 1053
Query: 1831 QLITLKKDVNETQKKVS-EMEQLKKQIKDQSLTLSKLEIENLNLAQKLH-ENLEEMKSVM 1888
L L++ + + + E ++ + K + L N+ +KL + E+++++
Sbjct: 1054 VLFQLEEGIEALEAAIEYRNESIQNRQKSLRASFHNLSRGEANVLEKLACLSPVEIRTIL 1113
Query: 1889 ----KERDNLRRVEETLKLERDQLKESLQETKARDLEIQQEL--------KTARMLSKEH 1936
+ NLR E +L +++K + E E++ L + + KEH
Sbjct: 1114 FRYFNKVVNLREAERKQQLYNEEMKMKVLERDNMVRELESALDHLKLQCDRRLTLQQKEH 1173
Query: 1937 KETVDKLREKISE----------KTIQ--ISDIQKDL---DKSKDELQKKIQEL 1975
++ + L E KT + I ++KDL K+ + +KK++EL
Sbjct: 1174 EQKMQLLLHHFKEQDGEGIMETFKTYEDKIQQLEKDLYFYKKTSRDHKKKLKEL 1227
Score = 97.8 bits (242), Expect = 1e-19
Identities = 194/1014 (19%), Positives = 420/1014 (41%), Gaps = 149/1014 (14%)
Query: 473 SNTLDTLSEIEW-NPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEK 531
SN ++L+ +++ N A + N+ + S R D + + + LR + + + +
Sbjct: 323 SNFDESLNSLKYANRARNIRNKPTVNFSPESDRID--EMEFEIKLLREALQSQQAGVSQT 380
Query: 532 NDLDEFEALERK---TKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKE 588
++ + + + ++Q QL E + V+ A + DL+ + +R E
Sbjct: 381 TQINREGSPDTNRIHSLEEQVAQLQGECLGYQCCVEEAFTFLVDLK-------DTVRLNE 433
Query: 589 DQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRE----SAFL 644
Q KLQE+ + ++ ++ + S I +++ L KRE L
Sbjct: 434 KQQHKLQEWFNM--IQEVRKAVLTSFRGIGGTASLEEG--PQHVTVLQLKRELKKCQCVL 489
Query: 645 RSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLI 704
++ + +K E+ K+++N +Q M V K + E K+ L
Sbjct: 490 AADEVVFNQKELEV----KELKNQVQ-----------MMVQENKGHAVSLKEAQKVNRLQ 534
Query: 705 DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELK-SLPSEVERLRK-E 762
+ K+ + L +L ++T L + +EN + + ++P +
Sbjct: 535 NEKIIEQQLLVDQLSEELTKLNLSVTSSAKENCGDGPDARIPERRPYTVPFDTHLGHYIY 594
Query: 763 IQDKSEELHIITSEK----DKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQE 818
I + + + TS D++F+ + + G +EE +D + Q + S D+E
Sbjct: 595 IPSRQDSRKVHTSPPMYSLDRIFAGFRTRSQMLLGHIEE----QDKVLHCQFSDNSDDEE 650
Query: 819 FQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEK 878
+ + + + ++ E+ + E QK D LK + ++QEL
Sbjct: 651 SEGQEKSGTRCRSRSWIQKPDSVCSLVELSDTQDETQKSDLENEDLKIDCLQESQELN-- 708
Query: 879 TREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQ 938
++L+N + L +++ +T ++ + +K L + +D K +
Sbjct: 709 --------------LQKLKNSERILTEAKQKMRELTINIKMKEDLIKELIKTGNDAKSVS 754
Query: 939 ESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHME 998
+ ++ +L+ D I+TQ+QL+ L++K +V+ + ++
Sbjct: 755 KQYSLKVTKLEHDAEQAKVELIETQKQLQE--------------LENKDLSDVAMKVKLQ 800
Query: 999 ENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM 1058
+ + D + ++ + KKQ ++K +L+ I+ +++ NEL+Q
Sbjct: 801 KEFRKKMDAAKLRVQVLQKKQQ-DSKKLASLS--------IQNEKRA-------NELEQS 844
Query: 1059 LESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG----E 1114
++ + +K QL+ L+E E + ++ ++K+ Q QE+ K E
Sbjct: 845 VDHMKYQKIQLQRKLREENEKRKQLDAVIKRDQQKIKEIQLKTGQEEGLKPKAEDLDACN 904
Query: 1115 LSRTCDRLAEVE--EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL--------- 1163
L R ++ +KL E+ + L E+ +++LN ++E+ E++ + + E +
Sbjct: 905 LKRRKGSFGSIDHLQKLDEQKKWLDEEVEKVLNQRQELEELEADLKKREAIVSKKEALLQ 964
Query: 1164 -KNELKNKEL-TLEHMETERLELAQKLN--------ENYEEVKSITKERKVLKELQKSFE 1213
K+ L+NK+L + + + T+ L+++ +LN +N + S +E+ + E + +
Sbjct: 965 EKSHLENKKLRSSQALNTDSLKISTRLNLLEQELSEKNVQLQTSTAEEKTKISEQVEVLQ 1024
Query: 1214 TERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEK 1273
E+D L+ ++ E+LK + E + + +L + A I E
Sbjct: 1025 KEKDQLQKRRHNVD-------EKLKNGRVLSPEEEHVLFQLEEGIEALEAAI------EY 1071
Query: 1274 SHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRL 1333
+ +Q + ++ L + +S + N LE L S + T L R + + L
Sbjct: 1072 RNESIQ------NRQKSLRASFHNLSRGE--ANVLEKLACLSPVEIRTILFRYFNKVVNL 1123
Query: 1334 NEKFQESQ---EEIKSLTKERDNL-KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQS 1389
E ++ Q EE+K ERDN+ + ++ AL+ H +L+ R TL + + Q Q
Sbjct: 1124 REAERKQQLYNEEMKMKVLERDNMVRELESALD--HLKLQCDRRLTLQQKEHEQKMQLLL 1181
Query: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE 1443
+ KE+D E ME FK + + ++E ++ K ++ ++K + E
Sbjct: 1182 HHFKEQDGE-----GIMETFKTYEDKIQQLEKDLYFYKKTSRDHKKKLKELVGE 1230
Score = 97.1 bits (240), Expect = 2e-19
Identities = 165/816 (20%), Positives = 356/816 (43%), Gaps = 103/816 (12%)
Query: 1272 EKSHTKLQEEIPVLHEEQEL-------LPNVKEVSETQETMNELELLTEQSTTKDSTTLA 1324
EK KLQE ++ E ++ + + E + + L+L E K LA
Sbjct: 433 EKQQHKLQEWFNMIQEVRKAVLTSFRGIGGTASLEEGPQHVTVLQLKRELK--KCQCVLA 490
Query: 1325 RIEMERLRLNEKFQESQEEIKSLTKE-RDNLKTIKEALEVKHDQLKEHIRETLA--KIQE 1381
E+ + + +E + +++ + +E + + ++KEA +V Q ++ I + L ++ E
Sbjct: 491 ADEVVFNQKELEVKELKNQVQMMVQENKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSE 550
Query: 1382 SQSKQEQSLNMKEKDN----ETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEM 1437
+K S+ K+N +I P D+ L G + D
Sbjct: 551 ELTKLNLSVTSSAKENCGDGPDARIPERRPYTVPFDTHL--------GHYIYIPSRQDSR 602
Query: 1438 K-SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ-EETINE 1495
K + L R+ ++ S L +I EE+ KV HC + ++ +E
Sbjct: 603 KVHTSPPMYSLDRIFAGFRTRSQMLLGHI----------EEQDKVLHCQFSDNSDDEESE 652
Query: 1496 LRVNLSEKETEISTIQK-----QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNEL 1550
+ + S IQK L ++D Q++ Q+ + E I + E QE L
Sbjct: 653 GQEKSGTRCRSRSWIQKPDSVCSLVELSDT-QDETQKSDLENEDLKIDCLQESQEL--NL 709
Query: 1551 KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK 1610
++ K + A Q KM ELT ++ ++ I+ +IK + K V + ++ +L+
Sbjct: 710 QKLKNSERILTEAKQ----KMRELTINIKMKEDLIKELIKTGNDAKSVSKQYSLKVTKLE 765
Query: 1611 ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRL 1670
+ ++ ++ E+Q K+ Q L+ +++ K+ + +++ + KL ++ ++ +
Sbjct: 766 HDAEQAKVELIETQ-KQLQELENKDLSDVAMKVKLQKEFRKKMDAAKLRVQVLQKKQQDS 824
Query: 1671 TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL 1730
++ +++ K ++L + +K ++ QL+ LRE + EK+++L V +
Sbjct: 825 KKLASLSIQN----EKRANELEQSVDHMKYQKIQLQRKLRE----ENEKRKQLDAV---I 873
Query: 1731 KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI 1790
K Q+ I + + KT + ++ L+ + L A +LK ++ + HL++ +
Sbjct: 874 KRDQQKIKE----IQLKTGQ----EEGLKPKAEDLDACNLKRRKGSFGSIDHLQK----L 921
Query: 1791 DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850
D+ + + E+ +K+ N +++LE A L+++ + I KK+ +K E +
Sbjct: 922 DEQKKWLDEEVEKVLNQRQELEELEADLKKR---------EAIVSKKEALLQEKSHLENK 972
Query: 1851 QLKKQIKDQSLTLSKLEIE-NLN-LAQKLHE-NLEEMKSVMKERDNLRRVEETLKLERDQ 1907
+L+ Q+L L+I LN L Q+L E N++ S +E+ + E L+ E+DQ
Sbjct: 973 KLR---SSQALNTDSLKISTRLNLLEQELSEKNVQLQTSTAEEKTKISEQVEVLQKEKDQ 1029
Query: 1908 LKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE 1967
L++ R + ++LK R+LS E + + +L E I I + + +
Sbjct: 1030 LQK-------RRHNVDEKLKNGRVLSPEEEHVLFQLEEGIEALEAAIEYRNESIQNRQKS 1082
Query: 1968 LQKKIQELQKKELQLL---------RVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRM 2018
L+ L + E +L ++ + K+ + + +++ + N M+ +
Sbjct: 1083 LRASFHNLSRGEANVLEKLACLSPVEIRTILFRYFNKVVNLREAERKQQLYNEEMKMKVL 1142
Query: 2019 DNFQLTKKLHESLEEIRIVAKERDELRRIKESLKME 2054
+ + ++L +L+ +++ R L++ + KM+
Sbjct: 1143 ERDNMVRELESALDHLKLQCDRRLTLQQKEHEQKMQ 1178
Score = 84.0 bits (206), Expect = 2e-15
Identities = 142/597 (23%), Positives = 246/597 (41%), Gaps = 79/597 (13%)
Query: 462 DESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEK 521
DE+ S+ + +D L E + KL N E I +E + + E L K
Sbjct: 684 DETQKSDLENEDLKIDCLQESQELNLQKLKNSERILTEAKQKMRELTINIKMKEDLI--K 741
Query: 522 EEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKV 581
E ++ K+ ++ K + D E + I K L E+ N+DL ++++ KV
Sbjct: 742 ELIKTGNDAKSVSKQYSLKVTKLEHDAEQAKVELIETQKQL---QELENKDL-SDVAMKV 797
Query: 582 ELLRE--KEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKR 639
+L +E K+ KL+ + +K ++ K S S+++ + +++Q++ + + +R
Sbjct: 798 KLQKEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRANELEQSVDHMKYQKIQLQR 857
Query: 640 ESAFLRSENLELKEKMKELATTYK---QMENDIQLYQSQLEAKKKMQVDLE----KELQS 692
+ LR EN EK K+L K Q +IQL Q E K DL+ K +
Sbjct: 858 K---LREEN----EKRKQLDAVIKRDQQKIKEIQLKTGQEEGLKPKAEDLDACNLKRRKG 910
Query: 693 AFNEITKLTSL------IDGKVPKDLLCNLELEGKITDLQKE-----------LNKEVEE 735
+F I L L +D +V K L ELE DL+K K E
Sbjct: 911 SFGSIDHLQKLDEQKKWLDEEVEKVLNQRQELEELEADLKKREAIVSKKEALLQEKSHLE 970
Query: 736 NEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLL 795
N+ LR L ++ + + + L +E+ +K+ +L T+E+ SE V
Sbjct: 971 NKKLRSSQALNTDSLKISTRLNLLEQELSEKNVQLQTSTAEEKTKISEQV---------- 1020
Query: 796 EEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQ 855
E + K KD L Q + D++ +N + L + E + E E + I ++ Q
Sbjct: 1021 EVLQKEKDQL---QKRRHNVDEKLKNGRVLSPEEEHVLFQLEEGIEALEAAIEYRNESIQ 1077
Query: 856 KFDSSLGALKTELSYKTQELQEKT-------------REVQERLNEME-QLKEQLENRDS 901
SL A LS + EK R + +N E + K+QL N +
Sbjct: 1078 NRQKSLRASFHNLSRGEANVLEKLACLSPVEIRTILFRYFNKVVNLREAERKQQLYNEEM 1137
Query: 902 TLQTVEREKTLITEKLQQTLEEVK------TLTQEKDDLKQLQESLQIERDQLKSDIHDT 955
++ +ER+ + +L+ L+ +K Q+K+ +++Q L ++Q I +T
Sbjct: 1138 KMKVLERDN--MVRELESALDHLKLQCDRRLTLQQKEHEQKMQLLLHHFKEQDGEGIMET 1195
Query: 956 VNMNIDTQEQLRNALESLKQ-HQETINTLKSKISEEVSRNL----HMEENTGETKDE 1007
D +QL L K+ ++ LK + E + R L + E G K E
Sbjct: 1196 FKTYEDKIQQLEKDLYFYKKTSRDHKKKLKELVGEAIRRQLAPSEYQEAGDGVLKPE 1252
Score = 73.6 bits (179), Expect = 3e-12
Identities = 171/858 (19%), Positives = 355/858 (41%), Gaps = 162/858 (18%)
Query: 1379 IQESQSKQEQSLNMKEKDNETTKIVSEME-QFKPKDSALLRIEIEMLGLSKRLQESHDEM 1437
+ S S ++SLN + N I ++ F P+ + +E E+ K L+E+
Sbjct: 318 VSPSSSNFDESLNSLKYANRARNIRNKPTVNFSPESDRIDEMEFEI----KLLREALQSQ 373
Query: 1438 KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELR 1497
++ + + R + L+E + ++ + L + CC++E + +L
Sbjct: 374 QAGVSQTTQINREGSPDTNRIHSLEEQVAQLQGECLGYQ-------CCVEEAFTFLVDL- 425
Query: 1498 VNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHR 1557
K +N+K Q+K+QE FN+ Q E R
Sbjct: 426 --------------KDTVRLNEKQQHKLQE------WFNMIQ---------------EVR 450
Query: 1558 KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIV 1617
KA ++ + I T L+E + + ++ + K E+K+ Q L + E+V
Sbjct: 451 KAVLTSFRGIGG-----TASLEEGPQHVTVL-QLKRELKKCQCVLAAD---------EVV 495
Query: 1618 AKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHEN 1677
KE + KE LK QE LKE + +L E I + + + Q+ E
Sbjct: 496 FNQKELEVKE---LKNQVQMMVQENKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSEEL 552
Query: 1678 LEEMRSVTKERDDLRSVEETLKVERD-QLKENLRETITRDLEKQEELKIVHMHLKEHQET 1736
+ SVT S +E D ++ E T+ D ++++ Q+
Sbjct: 553 TKLNLSVTS------SAKENCGDGPDARIPERRPYTVPFDTHLGH-----YIYIPSRQD- 600
Query: 1737 IDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGI 1796
S K + M +S D + A + + ++ + H+ E+Q+ + L
Sbjct: 601 --------SRKVHTSPPM-----YSLDRIFA-GFRTRSQMLLGHI---EEQDKV--LHCQ 641
Query: 1797 VSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQI 1856
S+ +D + ++ + + + IQ+ + L+ L +ETQK E E LK
Sbjct: 642 FSDNSDDEESEGQEKSGTRCRSRSWIQK-PDSVCSLVELSDTQDETQKSDLENEDLKIDC 700
Query: 1857 KDQS--------------LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902
+S LT +K ++ L + K+ E+L +K ++K ++ + V +
Sbjct: 701 LQESQELNLQKLKNSERILTEAKQKMRELTINIKMKEDL--IKELIKTGNDAKSVSKQYS 758
Query: 1903 LERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD 1962
L+ +L+ ++ K +E Q++L+ E+K+ +S+ +++ +QK+
Sbjct: 759 LKVTKLEHDAEQAKVELIETQKQLQEL-----ENKD--------LSDVAMKVK-LQKEFR 804
Query: 1963 KSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQ 2022
K D + ++Q LQKK+ ++ + K+ NE+EQ S+ ++ Q
Sbjct: 805 KKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRANELEQ----------SVDHMKYQKIQ 854
Query: 2023 LTKKLHESLEEIR----IVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE 2078
L +KL E E+ + ++ +++ +++ I+ LK +++ + E + D N + +
Sbjct: 855 LQRKLREENEKRKQLDAVIKRDQQKIKEIQ--LKTGQEEGLKPKAEDL--DACNLKRRKG 910
Query: 2079 KRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE--IEFQKELSM 2136
D Q L E + ++++L + E+++ L DL+K I +KE +
Sbjct: 911 SFGSIDHLQKLDEQKKWLDEEVEKVLNQRQELEE-------LEADLKKREAIVSKKEALL 963
Query: 2137 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM 2196
+ K++L L++ + L T + + S + + ++L + E+ I+
Sbjct: 964 QEKSHLENKKLRSS--QALNTDSLKISTRLNLLEQELSEKNVQLQTSTAEEKTKIS---- 1017
Query: 2197 DFIDEVEKQKELLIKIQH 2214
+ ++ ++K+K+ L K +H
Sbjct: 1018 EQVEVLQKEKDQLQKRRH 1035
Score = 57.4 bits (137), Expect = 2e-07
Identities = 112/581 (19%), Positives = 259/581 (44%), Gaps = 58/581 (9%)
Query: 334 YVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEK 393
Y +V+ E ++ + E+++ +KQL+E+ + + K +L + +K K++ +
Sbjct: 757 YSLKVTKLEHDAEQAKVELIETQKQLQELENKDLSDVAMKVKLQKEFRKKMDAAKLRVQV 816
Query: 394 IENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKL 453
++ + +SL++Q E +A + ++ MK Q + K +L
Sbjct: 817 LQKKQQDSKKLASLSIQNEKRANELEQ------SVDHMKYQKIQLQRKLREE-NEKRKQL 869
Query: 454 SINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLD 513
+ R+ + + L T E P + L+ N++ S D+L
Sbjct: 870 DAVIKRD-------QQKIKEIQLKTGQEEGLKPKAEDLDACNLKRRKGSF-GSIDHLQKL 921
Query: 514 YEQLRTEKEEMELKLKEKNDLDEFEA--LERKTKKDQEMQLIHEISNLKN-LVKHAEVYN 570
EQ + EE+E L ++ +L+E EA +R+ ++ L+ E S+L+N ++ ++ N
Sbjct: 922 DEQKKWLDEEVEKVLNQRQELEELEADLKKREAIVSKKEALLQEKSHLENKKLRSSQALN 981
Query: 571 QDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630
D ++S+++ LL ++ + +N+++ S + E + +Q++ +
Sbjct: 982 TD-SLKISTRLNLLEQELSE-------------KNVQLQTSTAEEKTKISEQVE--VLQK 1025
Query: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690
E L +R + + +N + +E Q+E I+ ++ +E + + + +K L
Sbjct: 1026 EKDQLQKRRHNVDEKLKNGRVLSPEEE--HVLFQLEEGIEALEAAIEYRNESIQNRQKSL 1083
Query: 691 QSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELK 750
+++F+ +++ + V + L C +E + T L + NK V EA R++ + E+K
Sbjct: 1084 RASFHNLSR----GEANVLEKLACLSPVEIR-TILFRYFNKVVNLREAERKQQLYNEEMK 1138
Query: 751 SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLL----EEIGK-TKDDL 805
E + + +E++ + L + +L + E ++Q LL E+ G+ +
Sbjct: 1139 MKVLERDNMVRELESALDHLKLQCDR--RLTLQQKEHEQKMQLLLHHFKEQDGEGIMETF 1196
Query: 806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK 865
T + + +++ +K D ++K K E + + I ++ ++ G LK
Sbjct: 1197 KTYEDKIQQLEKDLYFYKKTSRDHKKKLK------ELVGEAIRRQLAPSEYQEAGDGVLK 1250
Query: 866 TE-LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905
E ++EL+ +R +L+ E+ ++++ S+L+T
Sbjct: 1251 PEGGGMLSEELKWASRPESMKLSGRER---EMDSSASSLRT 1288
Score = 42.7 bits (99), Expect = 0.005
Identities = 69/299 (23%), Positives = 131/299 (43%), Gaps = 51/299 (17%)
Query: 2312 NESTEFEERSATI--SKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNP 2369
+E +E +E+S T S+ W Q S+ E +T K+ L + Q+++
Sbjct: 648 DEESEGQEKSGTRCRSRSWIQKPDSVCSLVELSDTQDETQKSDLENEDLKIDCLQESQ-- 705
Query: 2370 HVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESN 2429
+L +K++ E L EAK+ M + + IKM+++L + I AK
Sbjct: 706 -------ELNLQKLKNSERILTEAKQK-MRELTINIKMKEDL-IKELIKTGNDAKSVSKQ 756
Query: 2430 KCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATV 2489
L+ TK Q KV L ++++++L+ K + K+K KEF K++ A K V
Sbjct: 757 YSLKVTKLEHDAEQAKVELIET--QKQLQELENKDLSDVAMKVKLQKEFRKKMDAAKLRV 814
Query: 2490 EY----QKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALIL 2545
+ Q++ +L +++ ++A + +H +
Sbjct: 815 QVLQKKQQDSKKLASLSIQNEKRANELEQSVDH--------------------------M 848
Query: 2546 KSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEV--KTWKERTLKREAHKQVTC 2602
K + I+L++ KL+++NE+ KQ + ++ +Q E+ KT +E LK +A C
Sbjct: 849 KYQKIQLQR---KLREENEKR-KQLDAVIKRDQQKIKEIQLKTGQEEGLKPKAEDLDAC 903
>gi|45446749 kinesin family member 5A [Homo sapiens]
Length = 1032
Score = 281 bits (718), Expect = 8e-75
Identities = 273/968 (28%), Positives = 457/968 (47%), Gaps = 107/968 (11%)
Query: 4 EGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVY 63
E ++ V R RPLN E G+ ++ D++V+ G K + FDRVF N T + VY
Sbjct: 7 ECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVI---GGKPYVFDRVFPPNTTQEQVY 63
Query: 64 EEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMG---SEDHLGVIPRAIHDIFQKIKKF 120
A I+ + GYNGTIFAYGQT+SGKT+TM G +G+IPR DIF I
Sbjct: 64 HACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSM 123
Query: 121 PDR-EFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMAL 179
+ EF ++VSY EIY + I DLL T+ L + ED NR +V TE V + E L
Sbjct: 124 DENLEFHIKVSYFEIYLDKIRDLLDVTK--TNLSVHEDKNRVPFVKGCTERFVSSPEEIL 181
Query: 180 KWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVS-HLNLVDLAG 238
I +G+ +RH T MN+ SSRSH+IF + ++ N E K+S L LVDLAG
Sbjct: 182 DVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQ------ENMETEQKLSGKLYLVDLAG 235
Query: 239 SERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGG 298
SE+ ++TGA G L E NIN+SL LG VI L++G ++ YRDSK+TRILQ+SLGG
Sbjct: 236 SEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEG-TKSYVPYRDSKMTRILQDSLGG 294
Query: 299 NAKTRIICTITPVSFD--ETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLK 356
N +T + +P S++ ET + L F AK +KNT VN T E K+Y KE
Sbjct: 295 NCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKE----- 349
Query: 357 KQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAK 416
+T+AQ K+ +A+L E +L + E + R+ ++L +
Sbjct: 350 ------KEKTKAQ---KETIAKL--EAELSRWRNGENVPETERLAGEEAALGAE------ 392
Query: 417 RKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTL 476
+ + D +I I + + +R + + + + D +
Sbjct: 393 -------------LCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQS 439
Query: 477 DTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDE 536
+ +++ ++L+QE + L S R D + + + L++E + + ++KE
Sbjct: 440 QLIEKLK----QQMLDQEEL---LVSTRGDNEKVQRELSHLQSENDAAKDEVKE-----V 487
Query: 537 FEALER-KTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQ 595
+ALE DQ+ Q + E S NQ L +ELS KV + E ++++LQ
Sbjct: 488 LQALEELAVNYDQKSQEVEEKSQ----------QNQLLVDELSQKVATMLSLESELQRLQ 537
Query: 596 EYIDSQK------LENIKMDLS-YSL----ESIEDPKQMKQTLFDAETVA------LDAK 638
E Q+ L + DLS +S+ I+ P ++ + + TVA + ++
Sbjct: 538 EVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSE 597
Query: 639 RESAFLRSENLE--LKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNE 696
+S R LE E +++ T +++ + QL SQ EAK + + + ++
Sbjct: 598 VKSVVKRCRQLENLQVECHRKMEVTGREL-SSCQLLISQHEAKIRSLTEYMQSVELKKRH 656
Query: 697 ITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEV 756
+ + + ++ K E + D + + E +AL E+ + S ++ ++
Sbjct: 657 LEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKAL--ELQMESHREAHHRQL 714
Query: 757 ERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTD 816
RLR EI +K + + + KL E+ ++ + L E + L Y+ +
Sbjct: 715 ARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTFLYERHE 774
Query: 817 QEFQNFKTLHMDFEQKYKMVLEENERMNQEI---VNLSKEAQKFDS-SLGALKTELSYKT 872
Q Q+ K L ++ + + + Q++ V S E + DS + + K ++S+
Sbjct: 775 QSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLE 834
Query: 873 QELQEKTREVQERLNEMEQLKEQLENRDSTLQ-TVEREKTL---ITEKLQQTLEEVKTLT 928
L++ T+ ++ + + L+ +L + L+ T ER K L + E + +++ +
Sbjct: 835 NNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQ 894
Query: 929 QEKDDLKQ 936
QE D +K+
Sbjct: 895 QEVDRIKE 902
Score = 83.6 bits (205), Expect = 2e-15
Identities = 175/824 (21%), Positives = 354/824 (42%), Gaps = 130/824 (15%)
Query: 1285 LHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEI 1344
+HE++ +P VK +E + E E+L K + +A M NE S I
Sbjct: 156 VHEDKNRVPFVKGCTERFVSSPE-EILDVIDEGKSNRHVAVTNM-----NEHSSRSHS-I 208
Query: 1345 KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVS 1404
+ +++N++T ++ L K + E ++K + +++ N+ + + ++S
Sbjct: 209 FLINIKQENMET-EQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVIS 267
Query: 1405 EMEQ----FKP-KDSALLRIEIEMLGLSKRLQE---SHDEMKSVAKEKDDL---QRLQEV 1453
+ + + P +DS + RI + LG + R + A+ K L QR + +
Sbjct: 268 ALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTI 327
Query: 1454 LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLS-----EKETEIS 1508
+ S L+ ++ K+ + +E+ K Q+ETI +L LS E E
Sbjct: 328 KNTASVNLELTAEQWKKKYEKEKEKTKA-------QKETIAKLEAELSRWRNGENVPETE 380
Query: 1509 TIQKQLEAINDKLQNKIQEIYEKEEQFNIKQIS--EVQEKVNELKQFKEHRKAKDSALQS 1566
+ + A+ +L +E + + +I+ E Q+ E+++ + KD +
Sbjct: 381 RLAGEEAALGAEL---CEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQ 437
Query: 1567 IESKMLELTNRLQESQEEIQIMIK-EKEEMKRVQEALQIERDQLKENTKEIVAKMKE--- 1622
+S+++E + QEE+ + + + E+++R LQ E D K+ KE++ ++E
Sbjct: 438 -QSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAV 496
Query: 1623 -----SQE-KEYQFLKMTAVNETQEKMC-------EIEHLKEQFETQKLNLEN------- 1662
SQE +E V+E +K+ E++ L+E Q+ +
Sbjct: 497 NYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMK 556
Query: 1663 --------IETENIRLTQILHENLEEMRSV-----TKERDDLRSVEETLKVERDQLKENL 1709
+ I+L + +EE +V +K + +++SV V+R + ENL
Sbjct: 557 DLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSV-----VKRCRQLENL 611
Query: 1710 RETITRDLE-KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
+ R +E EL + + +H+ I L +E + ++ LE S D+L +
Sbjct: 612 QVECHRKMEVTGRELSSCQLLISQHEAKIRSL----TEYMQSVELKKRHLEESYDSLSDE 667
Query: 1769 DLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKAN 1828
K+Q + + + LK+++ T ++K LE +E A+
Sbjct: 668 LAKLQAQETVHEVALKDKE-----------PDTQDADEVKKALELQMESHRE------AH 710
Query: 1829 EHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVM 1888
QL L+ ++NE QK + E++ L +++ +LE+E KL + E++KS
Sbjct: 711 HRQLARLRDEINEKQKTIDELKDLNQKL--------QLELE------KLQADYEKLKSEE 756
Query: 1889 KERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKIS 1948
E+ + + E T ER + +S Q+ K + + +EL+T L K + V +K +
Sbjct: 757 HEK-STKLQELTFLYERHE--QSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSA 813
Query: 1949 EKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEA 2008
E + S + L+ +++L K QL+R D+ E+ +L+K+ A
Sbjct: 814 EMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRC------ELPKLEKRLRA 867
Query: 2009 QNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLK 2052
+ + V+ L + ++++ R + + E+ RIKE+++
Sbjct: 868 ---TAERVKALEGALKEAKEGAMKDKR---RYQQEVDRIKEAVR 905
Score = 78.2 bits (191), Expect = 1e-13
Identities = 173/825 (20%), Positives = 346/825 (41%), Gaps = 115/825 (13%)
Query: 444 TNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSL 503
TN++ K + ++ E S + LD + E + N + N S +S+
Sbjct: 152 TNLSVHEDKNRVPFVKGCTERFVSSPE---EILDVIDEGKSNRHVAVTNMNEHSSRSHSI 208
Query: 504 RADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLV 563
+++ +Q E E E KL K L + E+ +K E ++ E N+ +
Sbjct: 209 ------FLINIKQ---ENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSL 259
Query: 564 KHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQM 623
L S V K +I LQ+ + M + S S D +
Sbjct: 260 SALGNVISALAEGTKSYVPYRDSKMTRI--LQDSLGGNC--RTTMFICCSPSSYNDAETK 315
Query: 624 KQTLFD--AETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKK 681
+F A+T+ A S NLEL T +Q + + + + +A+K+
Sbjct: 316 STLMFGQRAKTIKNTA--------SVNLEL---------TAEQWKKKYEKEKEKTKAQKE 358
Query: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALRE 741
LE EL N VP+ L G+ L EL +E N+
Sbjct: 359 TIAKLEAELSRWRN---------GENVPE----TERLAGEEAALGAELCEETPVNDNSSI 405
Query: 742 EV-ILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800
V I E + E+ RL K++ DK +E++ + +KL +++ +E + + K
Sbjct: 406 VVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEK 465
Query: 801 TKDDLATTQSNYKSTDQE----FQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK 856
+ +L+ QS + E Q + L ++++QK + V EE + NQ +V+ E +
Sbjct: 466 VQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEV-EEKSQQNQLLVD---ELSQ 521
Query: 857 FDSSLGALKTELSYKTQELQEKTREVQERLNE-----MEQLKE--------QLENRDSTL 903
+++ +L++EL Q LQE + ++R+ E M+ L E +++
Sbjct: 522 KVATMLSLESEL----QRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEIS 577
Query: 904 QTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQ----ESLQIERDQLKSD--IHDTVN 957
+E E T+ + + EVK++ + L+ LQ +++ +L S +
Sbjct: 578 GAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHE 637
Query: 958 MNIDTQEQLRNALESLKQH-QETINTLKSKI----SEEVSRNLHMEENTGETKDEFQ-QK 1011
I + + ++E K+H +E+ ++L ++ ++E + +++ +T+D + +K
Sbjct: 638 AKIRSLTEYMQSVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKK 697
Query: 1012 MVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKT 1071
+ + + EA + Q A ++D EI E+Q+ I L +LQ LE + A+ E+LK+
Sbjct: 698 ALELQMESHREAHHRQ--LARLRD-EINEKQKTIDELKDLNQKLQLELEKLQADYEKLKS 754
Query: 1072 DLKE------NIEMTIENQEELRLLGDELKKQQEIVAQEKN--HAIKKEGELSRTCDRLA 1123
+ E + E E+ + +LK +E VA+E H ++K +
Sbjct: 755 EEHEKSTKLQELTFLYERHEQSK---QDLKGLEETVARELQTLHNLRKL--------FVQ 803
Query: 1124 EVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLE 1183
+V ++K+ ++ E + + ++++S ++ + ++ + +L L E +
Sbjct: 804 DVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADL---RCELPK 860
Query: 1184 LAQKLNENYEEVKSITKERKVLKE----LQKSFETERDHLRGYIR 1224
L ++L E VK++ K KE ++ ++ E D ++ +R
Sbjct: 861 LEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVR 905
Score = 78.2 bits (191), Expect = 1e-13
Identities = 122/644 (18%), Positives = 257/644 (39%), Gaps = 129/644 (20%)
Query: 1069 LKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSR--------TCD 1120
+K N+E+T E ++ + +K++E +K K E ELSR +
Sbjct: 327 IKNTASVNLELTAEQWKK------KYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETE 380
Query: 1121 RLAEVEEKL-KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179
RLA E L E ++ + V+ E QK EI L +L +K+ +
Sbjct: 381 RLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQ 440
Query: 1180 ERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKI 1239
+L Q++ + E + S + + ++ ++E D + ++E+ LQ EEL +
Sbjct: 441 LIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEV----LQALEELAV 496
Query: 1240 AHIHLKEHQETIDELRRSVSEKTAQ-----------IINTQDLEKSHTKLQEEIPVLHEE 1288
+ D+ + V EK+ Q + LE +LQE V +
Sbjct: 497 NY----------DQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQE---VSGHQ 543
Query: 1289 QELLPNV-----KEVSETQETM--NELELLTEQS-TTKDSTTLARIEMERLRLNEK---- 1336
++ + V K++SE + E++L E S ++ T+AR+ + +++ K
Sbjct: 544 RKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVK 603
Query: 1337 -----------------------------FQESQEEIKSLTKERDNLKTIKEALEVKHDQ 1367
+ + +I+SLT+ +++ K LE +D
Sbjct: 604 RCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQSVELKKRHLEESYDS 663
Query: 1368 LKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLS 1427
L + LAK+Q ++ E +L KE D + V K + L++E
Sbjct: 664 LSDE----LAKLQAQETVHEVALKDKEPDTQDADEV--------KKALELQMESHREAHH 711
Query: 1428 KRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLK 1487
++L DE+ K D+L+ L + LQ E ++L+ + +++ ++ E +L+ +
Sbjct: 712 RQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTFLYE 771
Query: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547
E++ ++ L+ + + + ++Q ++ + F VQ+
Sbjct: 772 RHEQS------------------KQDLKGLEETVARELQTLHNLRKLF-------VQDVT 806
Query: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD 1607
+K+ E + S + K+ L N L++ + + ++++ +++ L+
Sbjct: 807 TRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLR 866
Query: 1608 QLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKE 1651
E K + +KE++E A+ + + E++ +KE
Sbjct: 867 ATAERVKALEGALKEAKE--------GAMKDKRRYQQEVDRIKE 902
Score = 74.7 bits (182), Expect = 1e-12
Identities = 115/583 (19%), Positives = 235/583 (40%), Gaps = 106/583 (18%)
Query: 1893 NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTI 1952
NL E K + ++ KE + K +++ EL +R + E+ ++L + +
Sbjct: 334 NLELTAEQWKKKYEKEKEKTKAQKETIAKLEAEL--SRWRNGENVPETERLAGEEAALGA 391
Query: 1953 QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLS 2012
++ + D S ++ +E QK E ++ R+ + ++ +IN+ QL ++ + Q L
Sbjct: 392 ELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLD 451
Query: 2013 MQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQN 2072
+ + + +K V +E L+ ++ K E + + L E+ Q
Sbjct: 452 QEELLVSTRGDNEK----------VQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQK 501
Query: 2073 HQVKPEKRLLSDGQQHLTESLREKCSRIKEL---LKRYSEMDDHY-----ECLNRLSLDL 2124
Q EK S Q L + L +K + + L L+R E+ H E LN L DL
Sbjct: 502 SQEVEEK---SQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDL 558
Query: 2125 EK--------EIEFQKELSMRVKANLSLPYL-------QTKHIEKLFTANQRCSMEFHRI 2169
+ EI+ E+S ++ ++ L + K + K + +E HR
Sbjct: 559 SEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRK 618
Query: 2170 MK------------------KLKYVLSYVTKIK------EEQHESIN------------- 2192
M+ K++ + Y+ ++ EE ++S++
Sbjct: 619 MEVTGRELSSCQLLISQHEAKIRSLTEYMQSVELKKRHLEESYDSLSDELAKLQAQETVH 678
Query: 2193 -------KFEMDFIDEVEKQKELLIK---------IQHLQQDCDVPSRELRDLK-LNQNM 2235
+ + DEV+K EL ++ + L+ + + + + +LK LNQ +
Sbjct: 679 EVALKDKEPDTQDADEVKKALELQMESHREAHHRQLARLRDEINEKQKTIDELKDLNQKL 738
Query: 2236 DLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDR 2295
L +E++ D+ + +K+E + + +E+T E ++ D++ L+ + +E
Sbjct: 739 QLELEKLQADYEK-----LKSEEHEKSTKLQELTFLYERHEQSKQDLKGLEETVARELQT 793
Query: 2296 ICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLAS 2355
+ + F + + +S E E + +Q + L+ E+L K ++ L A
Sbjct: 794 LHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNAD 853
Query: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAM 2398
P + + + T E+++ LE +L EAKE AM
Sbjct: 854 LRCELPKLE---------KRLRATAERVKALEGALKEAKEGAM 887
Score = 73.2 bits (178), Expect = 3e-12
Identities = 148/776 (19%), Positives = 312/776 (40%), Gaps = 103/776 (13%)
Query: 1607 DQLKENTKEIVAKMKESQEKEYQFLKMTAVNE---TQEKMCEIEHLKEQFETQKLNLENI 1663
D+ K N V M E + + + E T++K+ +L + ++K++
Sbjct: 185 DEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGA 244
Query: 1664 ETENIRLTQILHENLEEMRSV-------TKERDDLRSVEETLKVERDQLKENLRETI--- 1713
E + + ++++L + +V TK R + T ++ +D L N R T+
Sbjct: 245 EGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMT-RILQDSLGGNCRTTMFIC 303
Query: 1714 -TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKI 1772
+ E K M + +TI + E T E +K E + KAQ I
Sbjct: 304 CSPSSYNDAETKSTLM-FGQRAKTIKNTASVNLELTAE--QWKKKYEKEKEKTKAQKETI 360
Query: 1773 QE-ELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ 1831
+ E ++ E ++L G + +L +NS+ ++ +E + E +
Sbjct: 361 AKLEAELSRWRNGENVPETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEE 420
Query: 1832 LITLKKDVNETQKKVSE----MEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSV 1887
+ L K +++ ++++ +E+LK+Q+ DQ L +N + ++L E +
Sbjct: 421 IRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAA 480
Query: 1888 MKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQEL--KTARMLSKEHKETVDKLRE 1945
E + + E L + DQ + ++E ++ + EL K A MLS E + + +L+E
Sbjct: 481 KDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESE--LQRLQE 538
Query: 1946 KISEKTIQISDIQKDLDKSKDELQKKI----------------QELQKKELQLLRVKEDV 1989
+ +I+++ L K E + +E L + ++K +V
Sbjct: 539 VSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEV 598
Query: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE 2049
K+ ++E L+ + + + + + + QL HE+ +IR + + + K
Sbjct: 599 KSVVKRCRQLENLQVECH-RKMEVTGRELSSCQLLISQHEA--KIRSLTEYMQSVELKKR 655
Query: 2050 SLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSE 2109
L+ D L ++ A++ + +K E + +K+ L+ +
Sbjct: 656 HLEESYDSLSDELAKLQAQETVHEVALKDK-----------EPDTQDADEVKKALE--LQ 702
Query: 2110 MDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRI 2169
M+ H E +R L EI ++ K I++L NQ+ +E ++
Sbjct: 703 MESHREAHHRQLARLRDEINEKQ-----------------KTIDELKDLNQKLQLELEKL 745
Query: 2170 MKKLKYVLSYVTKIKEEQHESINKF-EMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRD 2228
+ K+K E+HE K E+ F+ E +Q + Q L+ + +REL+
Sbjct: 746 QADYE-------KLKSEEHEKSTKLQELTFLYERHEQSK-----QDLKGLEETVARELQ- 792
Query: 2229 LKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNG 2288
L+ L ++++ +S ++ E + ++K+ FLE N + K+
Sbjct: 793 -TLHNLRKLFVQDVTTRVKKS--AEMEPEDSGGIHSQKQKISFLE---NNLEQLTKVHKQ 846
Query: 2289 IQKEN-DRICQVNNFFN------NRIIAIMNESTEFEERSATISKEWEQDLKSLKE 2337
+ ++N D C++ R+ A+ E +E + + ++Q++ +KE
Sbjct: 847 LVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKE 902
Score = 50.8 bits (120), Expect = 2e-05
Identities = 143/706 (20%), Positives = 277/706 (39%), Gaps = 126/706 (17%)
Query: 1882 EEMKSVMKERDNLRRVEETLKLERDQLKES--LQETKARDLEIQQELKTARMLSKEHKET 1939
EE+ V+ E + R V T E S L K ++E +Q+L L
Sbjct: 178 EEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYL------- 230
Query: 1940 VDKL-REKISEKTIQ--ISDIQKDLDKSKDELQKKIQELQK--------KELQLLRVKED 1988
VD EK+S+ + + D K+++KS L I L + ++ ++ R+ +D
Sbjct: 231 VDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQD 290
Query: 1989 -----------VNMSHKKINEMEQLKK-QFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI 2036
+ S N+ E F + ++++ N +LT + + E
Sbjct: 291 SLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYE--- 347
Query: 2037 VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRL--------------- 2081
KE+++ + KE+ IA L ++R R V +RL
Sbjct: 348 --KEKEKTKAQKET--------IAKLEAELSRWRNGENVPETERLAGEEAALGAELCEET 397
Query: 2082 -LSDGQQHLTESLREKCSRIKELLKR-YSEMDDHYECLNRLSLDLEK---EIEFQKELSM 2136
++D + E+ + +E ++R Y ++DD + +N+ S +EK ++ Q+EL +
Sbjct: 398 PVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLV 457
Query: 2137 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYV-LSYVTKIKE-EQHESINKF 2194
+ + + H++ + N E +++ L+ + ++Y K +E E+ N+
Sbjct: 458 STRGDNEKVQRELSHLQ---SENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQL 514
Query: 2195 EMDFIDE-VEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPS 2253
+D + + V L ++Q LQ+ + + ++ DL ++ E + P
Sbjct: 515 LVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLP- 573
Query: 2254 IKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNE 2313
E + EE+ R I K+K+ ++ R Q+ N +
Sbjct: 574 --VEISGAIE---------EEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVT 622
Query: 2314 STEFEERSATISKEWEQDLKSLKE-------KNEKLFKNYQTLKTSLASGAQVNPTTQ-- 2364
E IS+ E ++SL E K L ++Y +L LA Q T
Sbjct: 623 GRELSSCQLLISQH-EAKIRSLTEYMQSVELKKRHLEESYDSLSDELAK-LQAQETVHEV 680
Query: 2365 -------DNKNPHVTSRATQLTTEKIRE--------LENSLHEAKESAMHKESKIIKMQK 2409
D ++ +A +L E RE L + ++E +++ + K+Q
Sbjct: 681 ALKDKEPDTQDADEVKKALELQMESHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQL 740
Query: 2410 ELEVTNDIIAKLQAKVHESNKCL----------EKTKETIQVLQDKVALGAKPYKEEIED 2459
ELE KL+++ HE + L E++K+ ++ L++ VA + + +
Sbjct: 741 ELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDLKGLEETVAREL----QTLHN 796
Query: 2460 LKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR 2505
L+ V+ ++K + E E E S + QK+ I L NL +
Sbjct: 797 LRKLFVQDVTTRVKKSAEMEPEDS---GGIHSQKQKISFLENNLEQ 839
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 279 bits (714), Expect = 2e-74
Identities = 496/2405 (20%), Positives = 1004/2405 (41%), Gaps = 384/2405 (15%)
Query: 314 DETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDL--------KKQLEEVSLE 365
D+ +T + F+ T K ++ +NE + + KE ++L K+Q+EE +
Sbjct: 900 DQQVTEISFSMTEKMVQ----LNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEV 955
Query: 366 TRAQAMEKDQLA--------QLLEEKDLLQKVQNEKIENLTRMLVTSSSLT-----LQQE 412
+ D+++ +L E DLL+K ++ L L+ L L++E
Sbjct: 956 SSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEE 1015
Query: 413 L---KAKRKRRVTWC---LGKINKMK-NSNYADQFNIPTNITTKTHKLSINLLREIDESV 465
L K + K+ + G++ + K N Y+++ +T+K ++ I L + I E
Sbjct: 1016 LANLKDESKKEIPLSETERGEVEEDKENKEYSEKC-----VTSKCQEIEIYLKQTISEKE 1070
Query: 466 CSESDVFSNTLDTLS-EIEWNPATKLLNQ---------ENIESELNSLRADYDNLVL--- 512
+ + + L+ E ++ K +NQ + +++E++ +A L+
Sbjct: 1071 VELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNT 1130
Query: 513 ---DYEQLRTEKEEMELKLK-------EKNDLDEFEALERKTKKDQEMQLIHEISNLKNL 562
D + + KE + + K +L+E K K+ + +L +++ K +
Sbjct: 1131 DASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAI 1190
Query: 563 VKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQ 622
+K A+ + L EL ++++D +LQE D Q EN E+I D Q
Sbjct: 1191 LKKAQEKERHLREEL-------KQQKDDYNRLQEQFDEQSKEN---------ENIGD--Q 1232
Query: 623 MKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKM 682
++Q ++D K S + E+ ++E + + + +S L
Sbjct: 1233 LRQLQIQVRE-SIDGKLPSTD-QQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPS 1290
Query: 683 QVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREE 742
+ LQ + L + + K +ELE K++ EL K+ EE L+E+
Sbjct: 1291 HSEDASALQGGTSVAQIKAQLKEIEAEK-----VELELKVSSTTSELTKKSEEVFQLQEQ 1345
Query: 743 V----ILLSELKSLPSEVERLRKEIQDKSE-------------ELHIITSEKDKLFSEVV 785
+ + + LK++ E E + +Q K E EL E KL S+
Sbjct: 1346 INKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKE 1405
Query: 786 HKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845
S + G L E + A T+ + +QE K LH E + K E +ER+ Q
Sbjct: 1406 EDVSYLSGQLSE-----KEAALTKIQTEIIEQE-DLIKALHTQLEMQAK---EHDERIKQ 1456
Query: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREV----QERLNEMEQLKEQLENRDS 901
V L + QK +G E S Q++Q K + +E L E + L+E+L
Sbjct: 1457 LQVELCEMKQK-PEEIG----EESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARG 1511
Query: 902 TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 961
T++ +T+ L +V +EKD + LQ ERD+L +++ ++ N
Sbjct: 1512 TIER-------LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLEN-- 1562
Query: 962 TQEQLRNALESLKQHQETINTLKSKISEEVS--RNLHMEENTGETKDEFQQKMVGIDKKQ 1019
+ L ++ ESLK E + K K+ +E+ ++ + E+T E+Q+K + K+
Sbjct: 1563 --QSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAEST-----EWQEKHKELQKEY 1615
Query: 1020 DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
++ ++ + ++ NE Q + ++ QEK EL L S A K++ + L+E +
Sbjct: 1616 EILLQSYENVS-----NEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQE 1670
Query: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
E +E++R K+Q+ + +E+N ++ E+ D E E L + ++E
Sbjct: 1671 MEEMKEKMRKFAKS-KQQKILELEEENDRLR--AEVHPAGDTAKECMETLLSSNASMKE- 1726
Query: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
+L V+ E + KK + + K+ L + L+H ++E N E +
Sbjct: 1727 --ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKH----QIEGNVSKQANLEATEKHD 1780
Query: 1200 KERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS 1259
+ V +E +S E + T ++ K A+ + + + DE+ +
Sbjct: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
Query: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD 1319
+ +L+E I L EE++ KE S+T E NE L Q +TKD
Sbjct: 1841 QID--------------QLKERIAGLEEEKQ---KNKEFSQTLE--NEKNTLLSQISTKD 1881
Query: 1320 STTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKI 1379
L ++ E ++N Q+ QEE+ +TK +KE E + D L+E + LA++
Sbjct: 1882 GE-LKMLQEEVTKMNLLNQQIQEELSRVTK-------LKETAEEEKDDLEERLMNQLAEL 1933
Query: 1380 QESQSKQEQSLNMKEKDNETT--------KIVSEMEQFKP---KDSALLRIEIEMLGLSK 1428
S Q + + NE K VSE+E+ K K+ + EI L K
Sbjct: 1934 NGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEK 1993
Query: 1429 RLQESHDEM--KSVAKEKDDL--QRLQEVLQSESD---------QLKENIKEIVAKHLET 1475
+Q + E KS AKE +L ++ QEV Q + D L+ +K + E+
Sbjct: 1994 -IQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTES 2052
Query: 1476 EEELKVAHCCL-------KEQEETINELRVNLSEKETEISTI-----------QKQLEAI 1517
+++L++ L K+ + + +V L + ++E + + Q E++
Sbjct: 2053 QKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESV 2112
Query: 1518 NDKLQNKIQEI---YEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLEL 1574
+++ K +++ E+ E+ ++K+ +QEK++ L++ K H + + I+ + +
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVH---LEETIGEIQVTLNKK 2169
Query: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMT 1634
+Q+ QE + + + + +LQ +RD++ + K+ K ++ + + + +++
Sbjct: 2170 DKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL- 2228
Query: 1635 AVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSV 1694
+E C + LK+Q +++E ++ I ++++ H+ E + V
Sbjct: 2229 -----KEDNCSV--LKDQLRQMSIHMEELK---INISRLEHDKQIWESKAQTEVQLQQKV 2278
Query: 1695 EETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNM 1754
+TL+ E +L L ET Q EL + LK + +
Sbjct: 2279 CDTLQGENKELLSQLEETRHLYHSSQNELAKLESELK------------------SLKDQ 2320
Query: 1755 QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814
DL +S + K Q ++ +R ++ + + ++L + + S + +++
Sbjct: 2321 LTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI--- 2377
Query: 1815 NAKLQEKIQELKANEHQL-ITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNL 1873
N K Q+ I L E + + + + + K++ E+E L Q +++++ LE EN
Sbjct: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV---LEEENKKA 2434
Query: 1874 AQKLHENLEEMKSVMKER-------DNLRRVEETLKLERDQLKESLQETKARDLEI---- 1922
K ++ +E +K++ KE D+ + +L+ +RD++ Q+ + R L I
Sbjct: 2435 VDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEK 2494
Query: 1923 QQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK--KIQELQKKEL 1980
Q ++ A + + KE + LR + + + + + +L + +++L + I++ Q+K+L
Sbjct: 2495 DQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQL 2554
Query: 1981 QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE 2040
++++++ + +K E+LK+ EA + L S ++ +E
Sbjct: 2555 LEVQLQQNKELENKYAKLEEKLKESEEA---------------NEDLRRSFNALQ---EE 2596
Query: 2041 RDELRRIKESLKMERDQF---IATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKC 2097
+ +L + ESLK+ Q + L+E + Q+K ++ E +
Sbjct: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE-----------EEVHRLS 2645
Query: 2098 SRIKELLKRYSEMDDHYECLNRLSLDLEKEIE--FQKELSMRVKANLSLPYLQTKHIEKL 2155
+ KR +E+++ C+ + + EIE +KEL + + + +T+
Sbjct: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELK-HLHHDAGIMRNETE----- 2699
Query: 2156 FTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHL 2215
TA +R + E R + +++ L VTK + I F + ++ L
Sbjct: 2700 -TAEERVA-ELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDEL 2757
Query: 2216 QQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEW 2275
++ D +EL LK ++ + +L SE+ F TE
Sbjct: 2758 KRKYDASLKELAQLKEQGLLNRERDALL---SETAFSMNSTE------------------ 2796
Query: 2276 LNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSL 2335
N+ +EKL + +++++ +++ + N+ F + A++ E + L
Sbjct: 2797 ENSLSHLEKLNQQLLSKDEQLLHLSSQLEDS----YNQVQSFSKAMASLQNERDH----L 2848
Query: 2336 KEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKE 2395
+ EK K+ + + S A P + Q + + L+N +
Sbjct: 2849 WNELEKFRKSEEGKQRSAA-------------QPSTSPAEVQSLKKAMSSLQNDRDRLLK 2895
Query: 2396 SAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKE 2455
+ + + +++ +E+ + + A+LQ + +KTK Q++Q+++ ++
Sbjct: 2896 ELKNLQQQYLQINQEITELHPLKAQLQ-------EYQDKTK-AFQIMQEELRQENLSWQH 2947
Query: 2456 EIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSV- 2514
E+ L+M+ ++ + + +++ IS + + + +IR LR + S Q Q V
Sbjct: 2948 ELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSS---SSQTQPLKVQ 3004
Query: 2515 ISEHTDPQPSNKPLTCGGGSGIVQNTKAL------ILKSEHIRLEKEISKLKQQNEQLIK 2568
P+ S P G +V T+ L LK H + E I +L QL++
Sbjct: 3005 YQRQASPETSASP---DGSQNLVYETELLRTQLNDSLKEIH-QKELRIQQLNSNFSQLLE 3060
Query: 2569 QKNEL 2573
+KN L
Sbjct: 3061 EKNTL 3065
Score = 259 bits (662), Expect = 3e-68
Identities = 505/2388 (21%), Positives = 986/2388 (41%), Gaps = 409/2388 (17%)
Query: 480 SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEA 539
S++E+N T QE+++ L A + LV++ + + +K+ ++L+ K++ +E +A
Sbjct: 38 SDMEFNNTT----QEDVQERL----AYAEQLVVELKDIIRQKD-VQLQQKDEALQEERKA 88
Query: 540 LERKTKKDQEMQLIHEISNLKNLVKHAEVYNQD----------LENELSSKVELLREKED 589
+ K KK + +H + L +L K+ E E +LS + E+E
Sbjct: 89 ADNKIKKLK----LHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEM 144
Query: 590 QIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENL 649
+I+K++ + ++ + + E P Q + + + + + F+ +
Sbjct: 145 EIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQA 204
Query: 650 ELKEKMKELATTYKQMEND------IQLYQSQLEAKKKMQVDLEKELQSAFNEIT-KLTS 702
+L + E A E D ++L++ +L + Q D+E E+Q + KL
Sbjct: 205 QLSQTQAEQAAQQVVREKDARFETQVRLHEDEL-LQLVTQADVETEMQQKLRVLQRKLEE 263
Query: 703 LIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKE 762
+ V + + +L LQ+EL + N+ IL +L+ + +E LR
Sbjct: 264 HEESLVGRAQVVDL--------LQQELTAAEQRNQ------ILSQQLQQMEAEHNTLRNT 309
Query: 763 IQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNF 822
++ + EE I+ +K+ EV ++ L EE+ + ++ Q
Sbjct: 310 VETEREESKILL---EKMELEVAERKLSFHNLQEEMHHLLEQ-------FEQAGQAQAEL 359
Query: 823 KTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE-------- 874
++ + EQK+K +EE I++L K Q+ S+ ALK + S Q+
Sbjct: 360 ESRYSALEQKHKAEMEEK---TSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQS 416
Query: 875 ----------LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE- 923
LQ+K++E+ + LN + + + ++ S +TE+ +L++
Sbjct: 417 AQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKR 476
Query: 924 VKTLTQEK----------DDLKQLQESL--------------QIERDQLKSDIHDTVNMN 959
V L EK ++LK E L + +R+ + I D N
Sbjct: 477 VVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKR 536
Query: 960 IDTQEQL-RNALESL--KQHQE-TINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI 1015
+ E+ ++ LE+ ++H+E ++ L+ K ++E L ++ G+ +E +++
Sbjct: 537 SSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQ-GKRAEEADHEVLDQ 595
Query: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075
+ + +E + A +K +E + F L+ + + L +V EKEQ T+ +
Sbjct: 596 KEMKQMEGEGI----APIKMKVFLEDTGQDFPLMPNE---ESSLPAV--EKEQASTEHQS 646
Query: 1076 NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG-----ELSRTCDRLAEVEEKLK 1130
I L G ELK ++ + A+ G EL R ++ E+E
Sbjct: 647 RTSEEIS----LNDAGVELKSTKQD-GDKSLSAVPDIGQCHQDELERLKSQILELELNF- 700
Query: 1131 EKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNE 1190
K+Q++ EK N+ E+ E+ IE K N + ER +L ++
Sbjct: 701 HKAQEIYEK-----NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQV-- 753
Query: 1191 NYEEVKSITKERKVLKELQKSF-ETERDHLRGYIREIEATGLQTKE------ELKIAHIH 1243
+E+ +T+ R +K+L+ + E ER Y + L T++ E K +
Sbjct: 754 --KELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVK 811
Query: 1244 LKEHQETIDELRRSVSEKTAQI-----------------------INTQDLEKSHTKLQE 1280
++ Q +D+++ SE++ I I+++ E S Q+
Sbjct: 812 IEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQK 871
Query: 1281 EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQES 1340
E+ + +Q LL ++V Q+T+ E + + + + + ++ E+ L + +
Sbjct: 872 ELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTL 931
Query: 1341 QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETT 1400
+E++ L++ + K E LK++ E Q S+ + + ++ +K+N
Sbjct: 932 KEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN--- 988
Query: 1401 KIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQ 1460
EQ K K A L E+L RL+E +K +K++ L E + E ++
Sbjct: 989 ------EQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIP---LSETERGEVEE 1039
Query: 1461 LKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDK 1520
KEN KE K C + +E L+ +SEKE E+ I+K LE
Sbjct: 1040 DKEN-KEYSEK------------CVTSKCQEIEIYLKQTISEKEVELQHIRKDLE----- 1081
Query: 1521 LQNKIQEIYEKEEQFN--IKQISE-VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNR 1577
E EEQF +KQ+++ +Q+K N++ + +A+ S Q+I K+ +T+
Sbjct: 1082 ------EKLAAEEQFQALVKQMNQTLQDKTNQI----DLLQAEISENQAIIQKL--ITSN 1129
Query: 1578 LQESQEEIQIMIKE---------------KEEMKRVQEALQIERDQLKENTKEIV----A 1618
S + ++KE K E++ AL+ E++QL++ +E + A
Sbjct: 1130 TDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKA 1189
Query: 1619 KMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENL 1678
+K++QEKE + E +++ + L+EQF+ Q ENI + +L + E++
Sbjct: 1190 ILKKAQEKERHLRE-----ELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESI 1244
Query: 1679 EEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL----KEHQ 1734
+ T +++ S L E + + E+ ++ +L H
Sbjct: 1245 DGKLPSTDQQESCSST------------PGLEEPLFKATEQHHTQPVLESNLCPDWPSHS 1292
Query: 1735 ETIDKLRG-----IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789
E L+G + + EI + +LE + ++ K EE+ + +Q
Sbjct: 1293 EDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLE 1352
Query: 1790 IDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849
I+ L+ + E ++Q+ LE+S ++ ++ L+ + +L L+K ++ KK ++
Sbjct: 1353 IESLKTVSHEAEVHAESLQQKLESSQLQI-AGLEHLRELQPKLDELQKLIS---KKEEDV 1408
Query: 1850 EQLKKQIKDQSLTLSKLE---IENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD 1906
L Q+ ++ L+K++ IE +L + LH LE ER +VE E
Sbjct: 1409 SYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVE---LCEMK 1465
Query: 1907 QLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD--KS 1964
Q E + E +IQ++L+ A + KE + L+E++S I + K L +S
Sbjct: 1466 QKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVES 1525
Query: 1965 KDELQKKIQELQKKELQLLRVKED--VNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQ 2022
+ Q K ++ L LL+ + D + + + E + L E+ L+++ + D +
Sbjct: 1526 QVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEK 1585
Query: 2023 LTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ-----VKP 2077
L K++ ESL+ +I E E + + L+ E + + + E ++ + + Q V+
Sbjct: 1586 LVKEI-ESLKSSKIA--ESTEWQEKHKELQKEYEILLQSY-ENVSNEAERIQHVVEAVRQ 1641
Query: 2078 EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMR 2137
EK+ L G+ TE+ +++ K+L + EM++ E + + + +++I +E + R
Sbjct: 1642 EKQELY-GKLRSTEANKKETE--KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDR 1698
Query: 2138 VKANLSLPYLQTKH-IEKLFTAN-------QRCSMEFHRIMKKLKYVLSYVTKIKEEQHE 2189
++A + K +E L ++N +R ME+ + KK + ++S + EE +
Sbjct: 1699 LRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQD 1758
Query: 2190 SINKFEMDFIDEVEKQKELLIKIQHLQQ-------DCDVPSRELRDLKLNQNMDLHIEE- 2241
++ E V KQ L +H Q +P L+ + E
Sbjct: 1759 LKHQIE----GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSES 1814
Query: 2242 ----------ILKDFSESEFPSIKTEFQQV-------------LSNRKEMTQFLEEWLNT 2278
+ KDFS + I QQ+ KE +Q LE NT
Sbjct: 1815 VPSAKSANPAVSKDFSSHD--EINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNT 1872
Query: 2279 RFDIEKLKNG----IQKENDRICQVNNFFNNRIIAIM-------NESTEFEER------- 2320
K+G +Q+E ++ +N + + E + EER
Sbjct: 1873 LLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAE 1932
Query: 2321 -------------SATISKE-WEQDLKSLKEKNEKLFKNYQTL---KTSLASGAQ---VN 2360
A I E E ++K+LK+ +L + Q L KT + S + +
Sbjct: 1933 LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLE 1992
Query: 2361 PTTQDNKNPHVTSRATQL------TTEKIRELENSL--HEAKESAMHKESKIIKM----- 2407
K P S A +L +++++L+ ++ K SA+ + K ++
Sbjct: 1993 KIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTES 2052
Query: 2408 QKELEVTNDIIA-------KLQAKVHESNKCLEKTK-ETIQVLQDKVALGAK-------- 2451
QK+LE+T + +A K QA++ L+ T+ E +VL D + L +
Sbjct: 2053 QKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESV 2112
Query: 2452 --PYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRS--- 2506
K++ EDL+ +L + + + +K K ++++ A + + +E I ++ L +
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKE 2172
Query: 2507 -QQAQDT--SVISEHTDPQPSNKPLTCGGGSGIVQNTK-------ALILKSEHIRL-EKE 2555
QQ Q+ S +++ S L I + K A+ K E IRL E
Sbjct: 2173 VQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDN 2232
Query: 2556 ISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCE 2603
S LK Q Q+ EL N L ++ + W+ + +Q C+
Sbjct: 2233 CSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280
Score = 230 bits (587), Expect = 1e-59
Identities = 408/1996 (20%), Positives = 846/1996 (42%), Gaps = 299/1996 (14%)
Query: 812 YKSTDQEFQNFKTLHMDFEQKY----KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE 867
++ +D EF N T D +++ ++V+E + + Q+ V L ++ + AL+ E
Sbjct: 35 HQESDMEFNN--TTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDE-------ALQEE 85
Query: 868 LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL 927
++++ + +L + + E+++ + T+ E + +Q + K+
Sbjct: 86 RKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSE------EQLSKHDKSS 139
Query: 928 TQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKI 987
T+E+ ++++++ LQ E+++L S + + TQ Q +S + +E + +K ++
Sbjct: 140 TEEEMEIEKIKHKLQ-EKEELISTLQAQL-----TQAQAEQPAQSSTEMEEFV-MMKQQL 192
Query: 988 SEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS 1047
E+ ++ +T+ E + V +K E + + ++E+++ + +
Sbjct: 193 QEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQ------VRLHEDELLQ----LVT 242
Query: 1048 LIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDEL---KKQQEIVAQE 1104
+ E+QQ L L+ L+E+ E + + + LL EL +++ +I++Q+
Sbjct: 243 QADVETEMQQKLRV-------LQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQ 295
Query: 1105 KNHAIKKEGELSRTCDRLAEVEEKLKEKSQ-QLQEKQQQLLNVQEEMSEMQKKINEIENL 1163
+ L T + E + L EK + ++ E++ N+QEEM + ++ +
Sbjct: 296 LQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQA 355
Query: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYI 1223
+ EL+++ LE +E E+ I +K +ELQ + + +D +
Sbjct: 356 QAELESRYSALEQKHKAEME---------EKTSHILSLQKTGQELQSACDALKDQNSKLL 406
Query: 1224 REIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIP 1283
++ +Q+ + + Q+ D+L++ S++ +Q +N L++ T Q P
Sbjct: 407 QDKNEQAVQSAQTI----------QQLEDQLQQK-SKEISQFLNRLPLQQHETASQTSFP 455
Query: 1284 VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRL-NEKF--QES 1340
++ E + ++ Q+ + ELE K + L+ IE+E L+ NEK Q +
Sbjct: 456 DVYNEGTQAVTEENIASLQKRVVELE------NEKGALLLSSIELEELKAENEKLSSQIT 509
Query: 1341 QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQES-QSKQEQSLNMKEKDNET 1399
E ++ T E D EV + + + + +ES Q E + + K K E
Sbjct: 510 LLEAQNRTGEADR--------EVSEISIVDIANKRSSSAEESGQDVLENTFSQKHK--EL 559
Query: 1400 TKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQES------HDEMKSVAKEKDDLQRLQEV 1453
+ ++ EM++ + ++ A L+++++ KR +E+ EMK + E +++
Sbjct: 560 SVLLLEMKEAQ-EEIAFLKLQLQ----GKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVF 614
Query: 1454 LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE----IST 1509
L+ E + +E+ H +E ++N+ V L + + +S
Sbjct: 615 LEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSA 674
Query: 1510 I-------QKQLEAINDKLQ------NKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEH 1556
+ Q +LE + ++ +K QEIYEK K+IS + + + E K+ ++
Sbjct: 675 VPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADN 734
Query: 1557 RKAKDSALQS------IESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK 1610
+ +AL + K L + L+ +++++ + E E +R+ Q D L
Sbjct: 735 NSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLL 794
Query: 1611 ENTKEIVAKMKESQEKEYQF-LKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIR 1669
T++I + E++ K+ + + +++ Q + E L ++Q N E+ E
Sbjct: 795 --TEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852
Query: 1670 LTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMH 1729
+ + +EE+ +++ + + L +E+ + E L++TI EK +++ +
Sbjct: 853 RVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIE---EKDQQVTEISFS 909
Query: 1730 LKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789
+ E +++ + + EI +++ L + A +A+ +++E+ ++ LK+ +
Sbjct: 910 MTEKMVQLNEEKFSLGV---EIKTLKEQLNLLSRAEEAKKEQVEEDNEVSS-GLKQNYDE 965
Query: 1790 IDKLRGIVSEKTD-KLSNMQKDLENSNAKLQ-------EKIQELKANEHQLITLKKD--- 1838
+ I E+ + ++K+ E KLQ E +Q + E +L LK +
Sbjct: 966 MSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKK 1025
Query: 1839 ---VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLR 1895
++ET++ E ++ K+ ++ +T EIE + L Q + E E++ + K+ +
Sbjct: 1026 EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIE-IYLKQTISEKEVELQHIRKDLEEKL 1084
Query: 1896 RVEETLKLERDQLKESLQE-TKARDL---EIQQELKTARMLSKEHKETVDKLREKISEKT 1951
EE + Q+ ++LQ+ T DL EI + + L + + D + ++T
Sbjct: 1085 AAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKET 1144
Query: 1952 IQISD-IQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQN 2010
+ IS + K EL++KI L+K++ QL + ++ S K I + Q K++ +
Sbjct: 1145 VVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREE 1204
Query: 2011 LSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELR-RIKESL--------KMERDQFIAT 2061
L Q + D +L ++ E +E + + +L+ +++ES+ + E
Sbjct: 1205 LKQQ--KDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPG 1262
Query: 2062 LREMIARDRQNHQVKP--EKRLLSDGQQH-------------------LTESLREKC--- 2097
L E + + + H +P E L D H L E EK
Sbjct: 1263 LEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELE 1322
Query: 2098 ----SRIKELLKRYSEMDDHYECLNRLSLDLE--KEIEFQKELSMR-VKANLSLPYLQTK 2150
S EL K+ E+ E +N+ L++E K + + E+ ++ L LQ
Sbjct: 1323 LKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIA 1382
Query: 2151 HIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLI 2210
+E L + E +++ K + +SY++ E+ ++ K + + I++ E LI
Sbjct: 1383 GLEHLRELQPKLD-ELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQ-----EDLI 1436
Query: 2211 KIQHLQQDCDVPSRELRDLKLNQN---MDLHIEEILKDFSESEFPSIKTEFQQVLSNRKE 2267
K H Q + + R +L M EEI ++ + I+ + Q L +RKE
Sbjct: 1437 KALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQ--QIQRKLQAALISRKE 1494
Query: 2268 MTQ----FLEEWLNTRFDIEKLKNGI------------------------QKENDRICQV 2299
+ EE R IE+L + Q+E D++
Sbjct: 1495 ALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITE 1554
Query: 2300 --NNFFNNRIIAIMNES--------TEFEER---------SATI--SKEWEQDLKSLKEK 2338
+ N+ ++ ES TE +E+ S+ I S EW++ K L+++
Sbjct: 1555 MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKE 1614
Query: 2339 NEKLFKNYQTLKTSLASGAQ--VNPTTQDNKNPHVTSRATQL----TTEKIRELENSLHE 2392
E L ++Y+ + A Q V Q+ + + R+T+ T ++++E E + E
Sbjct: 1615 YEILLQSYENVSNE-AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEE 1673
Query: 2393 AKES----AMHKESKIIKMQKELEVTNDIIAKLQAKVHESN----KCLE-------KTKE 2437
KE A K+ KI+++++E ND +L+A+VH + +C+E KE
Sbjct: 1674 MKEKMRKFAKSKQQKILELEEE----ND---RLRAEVHPAGDTAKECMETLLSSNASMKE 1726
Query: 2438 TIQVLQDKVALGAKPYK----------EEIEDLKMKLVKIDLEKMKNAKEFEKEISATKA 2487
++ ++ + +K ++ EE++DLK + ++ ++ K N + EK + T
Sbjct: 1727 ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ-IEGNVSKQANLEATEKHDNQTNV 1785
Query: 2488 TVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALI--- 2544
T E + + E S + T SE S P S + L
Sbjct: 1786 TEEGTQSIPGETEEQDSLSMSTRPTC--SESVPSAKSANPAVSKDFSSHDEINNYLQQID 1843
Query: 2545 -LKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCE 2603
LK LE+E K K+ ++ L +KN LLS E+K +E K Q E
Sbjct: 1844 QLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQE 1903
Query: 2604 NSPKSPKVTGTASKKK 2619
+ K+ TA ++K
Sbjct: 1904 ELSRVTKLKETAEEEK 1919
Score = 204 bits (520), Expect = 7e-52
Identities = 337/1640 (20%), Positives = 690/1640 (42%), Gaps = 239/1640 (14%)
Query: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQ-LAQLLEEKDLLQKVQNEKIE 395
++ + EA K K++ + ++++EE+ + R A K Q + +L EE D L+ + +
Sbjct: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
Query: 396 NLTRMLVT--SSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKL 453
+ T SS+ ++++EL+ + T ++K S +++ ++ + H++
Sbjct: 1709 TAKECMETLLSSNASMKEELERVKMEYET-----LSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Query: 454 SINLLREIDESVCSESDVFSN-----TLDTLSEIEWNPATKLLNQENIESELNSLRADYD 508
N+ ++ + + D +N T E E + + + + S ++
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1823
Query: 509 NLVLDYEQLRTEKEEMELKLKEKNDLDE-FEALERKTKKDQEMQLIHEISNLKNLVKHAE 567
+ D+ + +E+ L++ + L E LE + +K++E
Sbjct: 1824 AVSKDF----SSHDEINNYLQQIDQLKERIAGLEEEKQKNKE------------------ 1861
Query: 568 VYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTL 627
++Q LENE ++ + + K+ ++K LQE + L N ++ E + ++K+T
Sbjct: 1862 -FSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQ-----EELSRVTKLKET- 1914
Query: 628 FDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLE 687
AE D + L ++ EL + + +L +S+++ KK +LE
Sbjct: 1915 --AEEEKDDLEER---LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELE 1969
Query: 688 KELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLS 747
+E Q E TK ++ ++ K+ L KI QKE + E L
Sbjct: 1970 EEKQQLVKEKTK----VESEIRKEYL------EKIQGAQKEPGNKSHAKE-------LQE 2012
Query: 748 ELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLAT 807
LK EV++L+K+ E++ + E+ E V ES+ +++ TK++LA
Sbjct: 2013 LLKEKQQEVKQLQKDCIRYQEKISAL--ERTVKALEFVQTESQ-----KDLEITKENLAQ 2065
Query: 808 TQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE 867
+ K E +FK L D + + VL +N ++ +E+ S+ ++K++
Sbjct: 2066 AVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKEL----------QSNKESVKSQ 2115
Query: 868 LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL 927
+ K ++L+ + + +E+ LKE+ +N L + REK L++T+ E++
Sbjct: 2116 MKQKDEDLERRLEQAEEK-----HLKEK-KNMQEKLDALRREKV----HLEETIGEIQVT 2165
Query: 928 TQEKD-DLKQLQESLQIERDQLK------SDIHDTVNMNIDTQEQ--------LRNALES 972
+KD +++QLQE+L QL S + D + ID ++ +++ E
Sbjct: 2166 LNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEE 2225
Query: 973 LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQ---DLEAKNTQTL 1029
++ ++ + LK ++ + ++HMEE K + K Q L+ K TL
Sbjct: 2226 IRLKEDNCSVLKDQLRQ---MSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTL 2282
Query: 1030 TADVKDN-EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELR 1088
+ K+ +E+ R ++ Q NEL ++ + + K+QL TDL ++E E + L
Sbjct: 2283 QGENKELLSQLEETRHLYHSSQ--NELAKLESELKSLKDQL-TDLSNSLEKCKEQKGNL- 2338
Query: 1089 LLGDELKKQQEIVAQEKNHAIKK-EGELSRTCDRLAEVEEKLKEKSQQ----LQEKQQQL 1143
+ + +QQE Q + ++ E +L + + + + E++ K Q+ L K++ +
Sbjct: 2339 ---EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAI 2395
Query: 1144 -LNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKER 1202
+ + E + K+I E+ENL ++ + + + LE E + K N+ E +K+I KE
Sbjct: 2396 QVAIAELRQQHDKEIKELENLLSQEEEENIVLEE---ENKKAVDKTNQLMETLKTIKKEN 2452
Query: 1203 KVLKELQKSF-------ETERDHLRGYIREIEATGLQT-KEELKIAHIHLKEHQETIDEL 1254
K SF + +RD + G +++E L E+ ++ E+ + +E+
Sbjct: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEI 2512
Query: 1255 RRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQ--ETMNELELLT 1312
R S + DL + KL E+ E+ + +K+ + Q E +
Sbjct: 2513 RGLRS-------HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKEL 2565
Query: 1313 EQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTI-------------KE 1359
E K L E L F QEE + L+KE ++LK +
Sbjct: 2566 ENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEG 2625
Query: 1360 ALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK----DNETTKIVSEMEQFKPK--- 1412
L + H QLK E S Q++ ++E+ E K V E+E K
Sbjct: 2626 TLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELK 2685
Query: 1413 ----DSALLRIEIE-----MLGLSKRLQESHDEMKSVAKEKDDLQ-------RLQEVLQS 1456
D+ ++R E E + L++ L E ++ V KE L R LQ+
Sbjct: 2686 HLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQN 2745
Query: 1457 ESDQLKENIKEIVAKH---LETEEELKVAHCCLKEQEETINELRVNL-SEKETEISTIQK 1512
D E + E+ K+ L+ +LK +E++ ++E ++ S +E +S ++K
Sbjct: 2746 SRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEK 2805
Query: 1513 QLEAINDK------LQNKIQEIYEKEEQFNIKQISEVQEKV---NELKQFKEHRKAKD-S 1562
+ + K L +++++ Y + + F+ S E+ NEL++F++ + K S
Sbjct: 2806 LNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRS 2865
Query: 1563 ALQSIES--KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM 1620
A Q S ++ L + Q + ++KE + ++ Q+ LQI ++ + + + +
Sbjct: 2866 AAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ--QQYLQINQEITELHPLKAQLQE 2923
Query: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680
+ + K +Q ++ E E+ L+ + + +++ ++ + + + L
Sbjct: 2924 YQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSH 2983
Query: 1681 MRSVTKERDDLRSVEETLKVE--------------------------RDQLKENLRETIT 1714
++++ +E S + LKV+ R QL ++L+E
Sbjct: 2984 LQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQ 3043
Query: 1715 RDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQE 1774
++L Q+ L L E + T+ S+ E DL + L+ Q ++Q
Sbjct: 3044 KELRIQQ-LNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQA 3102
Query: 1775 ---ELRIAH--------MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQ 1823
+ +A +H K E + + + SE +L N ++++ L+E+
Sbjct: 3103 GPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERD 3162
Query: 1824 ELKANEHQLITLKKDVNETQ 1843
+ A E+ L ++ + +
Sbjct: 3163 QRVAAENALSVAEEQIRRLE 3182
Score = 178 bits (452), Expect = 6e-44
Identities = 292/1399 (20%), Positives = 595/1399 (42%), Gaps = 248/1399 (17%)
Query: 373 KDQLAQLLEEK----DLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRK---RRVTWCL 425
K+++A L EEK + Q ++NEK L+++ L + QE K +++ L
Sbjct: 1846 KERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL 1905
Query: 426 GKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWN 485
++ K+K + ++ ++ + +N L E++ S+ N +++ +
Sbjct: 1906 SRVTKLKETAEEEKDDLEERL--------MNQLAELNGSI-------GNYCQDVTDAQ-- 1948
Query: 486 PATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEK-------------N 532
+ E +ESE+ +L+ L + +QL EK ++E +++++ N
Sbjct: 1949 -----IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGN 2003
Query: 533 DLDEFEALERKTKKDQEMQLIHE--------ISNLKNLVKHAEVYNQDLENELSSKVELL 584
E E +K QE++ + + IS L+ VK E + + +L E L
Sbjct: 2004 KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENL 2063
Query: 585 REKEDQIKKLQEYIDSQKL--------------ENIKM--DLSYSLESIEDPKQMK---- 624
+ + KK Q + S K+ +N+K+ +L + ES++ + K
Sbjct: 2064 AQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDL 2123
Query: 625 -QTLFDAETVALDAKRESA----FLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAK 679
+ L AE L K+ LR E + L+E + E+ T + + ++Q Q L++
Sbjct: 2124 ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDST 2183
Query: 680 -----------KKMQVDLEKELQSAFNEITKLTSLIDGK------------VPKDLLCNL 716
+Q D ++ + A K + I K V KD L +
Sbjct: 2184 VTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQM 2243
Query: 717 EL---EGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHII 773
+ E KI + E +K++ E++A E + +L E + L ++++ H
Sbjct: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSS 2303
Query: 774 TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKY 833
+E KL SE+ + ++ L + K K+ + + + + QN K + E
Sbjct: 2304 QNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDL 2363
Query: 834 KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQEL-QEKTREVQERLNEMEQL 892
+ E R+++EI + + QK S L + + EL Q+ +E++E N + Q
Sbjct: 2364 QASRELTSRLHEEI---NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQE 2420
Query: 893 KEQL-----ENR---DSTLQTVEREKTLITEKLQQT------LEEVKTLTQEKD----DL 934
+E+ EN+ D T Q +E KT+ E +QQ ++ + +L ++D D
Sbjct: 2421 EEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDY 2480
Query: 935 KQLQE---SLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEV 991
+QL+E S+ +E+DQL I + N +E++R L+ H + +N+ +K+ E+
Sbjct: 2481 QQLEERHLSIILEKDQL---IQEAAAENNKLKEEIRG----LRSHMDDLNSENAKLDAEL 2533
Query: 992 SRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQT-LTADVKDNEII-EQQRKIFSLI 1049
+ KD Q++++ + +Q+ E +N L +K++E E R+ F+ +
Sbjct: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593
Query: 1050 QE-KNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHA 1108
QE K +L + +ES+ QL + ++ + L L +LK V +E+ H
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVT-----ALQEEGTLGLYHAQLK-----VKEEEVHR 2643
Query: 1109 IKKEGELSRTCDRLAEVEEKL----KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLK 1164
+ S + R+AE+EE+L KE ++++ E + +L E++ ++ ++
Sbjct: 2644 LS--ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKL------KKELKHLHHDAGIMR 2695
Query: 1165 NELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIR 1224
NE + E + + + +E+ QKL +E K +T + + S + RDH +
Sbjct: 2696 NETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELD 2755
Query: 1225 EIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN-TQDLEKSHTK------ 1277
E L+ K + + + + Q ++ R ++ +TA +N T++ SH +
Sbjct: 2756 E-----LKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQL 2810
Query: 1278 LQEEIPVLHEEQELLPNVKEVSETQETM-----------NELELLT------EQSTTKDS 1320
L ++ +LH +L + +V + M NELE ++S + S
Sbjct: 2811 LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPS 2870
Query: 1321 TTLARIEM----------ERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK- 1369
T+ A ++ +R RL ++ + Q++ + +E L +K L+ D+ K
Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKA 2930
Query: 1370 -----EHIR-ETLA---------------KIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408
E +R E L+ +I E + K++ + + +KD + + + + + +
Sbjct: 2931 FQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRE 2990
Query: 1409 FKPKDSALLRIEIE-MLGLSKRLQESHDEMKSVAKEKDDLQR-----LQEVLQSES--DQ 1460
+ S ++++ S S D +++ E + L+ L+E+ Q E Q
Sbjct: 2991 LRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQ 3050
Query: 1461 LKENIKEIVAKHLETEEELKVAHC----CLKEQEETINELRVNLSEKETEISTIQK---Q 1513
L N ++ LE + L + C L+E ++ +L + + E ++ +Q
Sbjct: 3051 LNSNFSQL----LEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLN 3106
Query: 1514 LEAINDKLQNKI--------QEIYEKEEQFNI--KQISEVQEKVNELKQFKEHRKAKDSA 1563
++ Q K +E+ E ++ F+ +Q+ +++VNEL++ E + + A
Sbjct: 3107 IDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVA 3166
Query: 1564 LQSIESKMLELTNRLQESQ 1582
++ S E RL+ S+
Sbjct: 3167 AENALSVAEEQIRRLEHSE 3185
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 270 bits (691), Expect = 1e-71
Identities = 512/2516 (20%), Positives = 1046/2516 (41%), Gaps = 366/2516 (14%)
Query: 339 STDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLT 398
S+ LL + + + +L+ ++ E LE R Q EK+ Q+ + ++L +++ K+E +
Sbjct: 274 SSSPHLLDQLKAQNQELRNKINE--LELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIE 331
Query: 399 RMLVTSS---SLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSI 455
+ V + L + + T K+ K+ + N + + K+
Sbjct: 332 KEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK- 390
Query: 456 NLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYE 515
+E E + + F +++ +L +N+ N L+A+ D L +
Sbjct: 391 EKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH---NVLQAELDKLTSVKQ 447
Query: 516 QLRTEKEEMELKL------------KE---KNDLDEFEALERKTKKDQEMQ------LIH 554
QL EE + KL KE + ++E + K E + L
Sbjct: 448 QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507
Query: 555 EISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSL 614
E+ N+K + ++ + ++++ + +S+ +LR+ +++I + + + +KL+ DL
Sbjct: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR 567
Query: 615 ESIEDPKQMKQTLFDA--ETVALDAKRESAFLRSENLELK--EKMKELATTYK------- 663
+ +D + ++ + + ++ K A L + L+ K E++KE T +
Sbjct: 568 DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENE 627
Query: 664 ----QMENDIQLYQSQLE----AKKKMQV----------DLEKELQSAFNEITKLTSLID 705
QME++ + QS++ K Q+ LE + ++ EI L +++D
Sbjct: 628 KLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLD 687
Query: 706 GK---VPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKE 762
K V L +EL+ K ++ KE+ EN L+ L +++ L +++ L E
Sbjct: 688 SKSVEVETQKLAYMELQQKAEFSDQKHQKEI-ENMCLKTSQ-LTGQVEDLEHKLQLLSNE 745
Query: 763 IQDKS---EELH--------IITSEKDKLFSEVVHKESRV---------QGLLEEIGKTK 802
I DK ++LH ++ S+ L + H+ S + IG+
Sbjct: 746 IMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQG 805
Query: 803 DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLG 862
+ DQ +N L + + LE ++MN + L K+ ++ G
Sbjct: 806 SMPSERSECRLEADQSPKNSAILQNRVD-SLEFSLESQKQMNSD---LQKQCEELVQIKG 861
Query: 863 ALKTELSYKTQELQEKTREVQERLNEMEQLKEQLEN----RDSTLQTVEREKTLITEKLQ 918
++ L Q Q E +R++++++ +N S L+ E+E L+ +K++
Sbjct: 862 EIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVE 921
Query: 919 QTLEEVKTLTQE----KDDLKQLQ---ESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
E++ L + +D LK+LQ E+L +E+ ++ S +++N E+L
Sbjct: 922 TEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS----IISLNKREIEELTQENG 977
Query: 972 SLKQHQETINTLKSKI---SEEVSRNL-HMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ 1027
+LK+ ++N K + SE + + E++ E D+++Q+ + + ++ + +
Sbjct: 978 TLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYE 1037
Query: 1028 TLTADVKDNEIIEQQRKIFSLIQE--------KNELQQMLESVIAEKEQLKTDL------ 1073
L+ K + E+ K+ L+ E KNEL+Q+ E+ E ++ T L
Sbjct: 1038 DLSQKYKAAQ--EKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEER 1095
Query: 1074 KENIEMTIE------------NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDR 1121
+N+ + +E NQ + LK++ + +E+N K+ +L + ++
Sbjct: 1096 NQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQ 1155
Query: 1122 LAEVEEKLKEKSQQLQ-----------EKQQQLLNVQEEMSEMQKKIN------EIENLK 1164
L +V K K + Q L+ E ++ N + +M K+I+ ++ L+
Sbjct: 1156 LMKV-MKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLE 1214
Query: 1165 NELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIR 1224
L+NKEL L+ E E+ L +L ++++ + +E+ + E D YI
Sbjct: 1215 AMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYIS 1274
Query: 1225 -----------------EIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN 1267
++ T + E KI I E E + EL S SE I
Sbjct: 1275 GPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSE---CITA 1331
Query: 1268 TQDLEKSHTKLQEEIPVLHEEQELLPN--VKEV--SETQETMNELELLT----EQSTTKD 1319
T+ + + KL E+ +L+++ LL V+++ E E NE ++ ++S + +
Sbjct: 1332 TRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYE 1391
Query: 1320 STTLA--RIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEH--IRET 1375
TL+ ++M L EKF Q E K L + + + L+ D LK + T
Sbjct: 1392 HLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLST 1451
Query: 1376 LAKIQESQSKQEQSLNMKE---KDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRL-- 1430
+ + +E L ++E ++ + DS+ R +E G L
Sbjct: 1452 NLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSN 1511
Query: 1431 --------QESHDEMKSVAKEKDDLQRLQ-EVLQSESDQLKENIKEIVAKHLETEEELKV 1481
Q S DE+ + ++++L R + ++ + E++ E+ + LE EE
Sbjct: 1512 LEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKME 1571
Query: 1482 AHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQIS 1541
+ +K +E I EL LS + E+ ++KQ + N++ Q K+ + + E +
Sbjct: 1572 SQGIMKNKE--IQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKK 1629
Query: 1542 EVQEKVNELKQFKEHRKAKDSALQSI-------------------ESKMLELTNRL---- 1578
+ ++ EL+ + + D + +S+ + E T R
Sbjct: 1630 QTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHD 1689
Query: 1579 ------QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE-YQFL 1631
+++Q+++ + I++ E V+ + +Q + E + K E L
Sbjct: 1690 VHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISEL 1749
Query: 1632 KMTAVNETQEKMCEIEHLKEQFETQKLNLENIET--ENIRLTQILHENLEEMRSVTKERD 1689
+ N + ++ L Q + L L ET EN+RL ++ + ++ S+ E
Sbjct: 1750 SFSGPN----ALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMK 1805
Query: 1690 DLRS------VEETLKVER----DQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDK 1739
+L S V+ K+E +++ L++ + EK E H L + ET +
Sbjct: 1806 ELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEG 1865
Query: 1740 LRGIVSEKTNEIS--NMQKDLEHSNDALKAQDLKIQEEL-RIAHMHLKEQQETIDKLRGI 1796
L + ++ S ++ ++ ND+ K + L ++ EL RI + E + +
Sbjct: 1866 LNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADL 1925
Query: 1797 VSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQI 1856
+T+KL ++KD EN + +EL + L+ +++ KK + ++QL +++
Sbjct: 1926 EVVQTEKLC-LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKM 1984
Query: 1857 KDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE---------RDNLRRVEETLKLERDQ 1907
K+++ L + E L+ Q ++E +++ +D E+ LE+D
Sbjct: 1985 KEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS 2044
Query: 1908 LKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKS--- 1964
SL + + + +I Q K +L KE + L+ ++SE + ++ K L+ +
Sbjct: 2045 QALSLTKCELEN-QIAQLNKEKELLVKES----ESLQARLSESDYEKLNVSKALEAALVE 2099
Query: 1965 KDELQKKIQELQKKELQLLRVKEDVNM-----SHKKINEMEQLKKQFEAQNLSMQSVRMD 2019
K E ++ Q++ QL R E + + K+++ E+LK++ E +N S++ +++
Sbjct: 2100 KGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKER-ERENDSLKD-KVE 2157
Query: 2020 NFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEK 2079
N + ++ E +E+ I+ E + E+LK + ++ +L+ + +
Sbjct: 2158 NLERELQMSEENQELVILDAENSKAE--VETLKTQIEEMARSLKVF----------ELDL 2205
Query: 2080 RLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVK 2139
L +++LT+ ++EK ++ EL K S SL EKE Q E+ ++ +
Sbjct: 2206 VTLRSEKENLTKQIQEKQGQLSELDKLLSSFK---------SLLEEKE---QAEIQIKEE 2253
Query: 2140 ANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFI 2199
+ ++ LQ + E C + IMK + L + + + SI K
Sbjct: 2254 SKTAVEMLQNQLKELNEAVAALCGDQ--EIMKATEQSLDPPIEEEHQLRNSIEKLRARLE 2311
Query: 2200 DEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQ 2259
+ +KQ +L +++ + D+ L+ N +L I ++ + E + K E +
Sbjct: 2312 ADEKKQLCVLQQLKESEHHADL----LKGRVENLERELEIARTNQEHAALEAENSKGEVE 2367
Query: 2260 QVLSNRKEMTQFLE----EWLNTRFDIEKLKNGIQKENDRICQ---VNNFFNNRIIAIMN 2312
+ + + MTQ L + + R + E L N +QKE +RI + +N+ F N +
Sbjct: 2368 TLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQ 2427
Query: 2313 ESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVT 2372
E + +E+S+T + + LK L E+ L + + K K +++
Sbjct: 2428 EKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA---------------KEQNLS 2472
Query: 2373 SRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCL 2432
S+ L EK + L+ L EAK + + +S + + +E+E + + L
Sbjct: 2473 SQVECLELEKAQLLQ-GLDEAKNNYIVLQSSVNGLIQEVE--------------DGKQKL 2517
Query: 2433 EKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQ 2492
EK E I L K +I+D + + K+ + ++ E+ + TVE +
Sbjct: 2518 EKKDEEISRL-----------KNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE 2566
Query: 2493 KEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNK-PLTCGGGSGIVQNTKALILKSEHIR 2551
+++ L +N QDT + + + N+ LT V+ + K ++
Sbjct: 2567 QKIQVLQSKN----ASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQ 2622
Query: 2552 LE--KEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENS 2605
E + K + E+L +KN L Q L E+K+ K++ K++T ENS
Sbjct: 2623 REMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQL------KELTLENS 2672
Score = 246 bits (629), Expect = 2e-64
Identities = 531/2591 (20%), Positives = 1040/2591 (40%), Gaps = 393/2591 (15%)
Query: 320 LQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQL 379
L+ + +K+ Y V T E + EI +L L+ S+E Q + +L Q
Sbjct: 647 LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
Query: 380 LEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQ 439
E D QK Q E IEN M + +S LT Q E + + ++ + ++ +A+
Sbjct: 707 AEFSD--QKHQKE-IEN---MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY 760
Query: 440 FNIPTNITTKTHKLSIN-----LLREIDES----------VCSESDVFSNTLDTLSEIEW 484
++ + +K L N L D+ + + + S + E +
Sbjct: 761 ESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
Query: 485 NPATKLLNQENIES------ELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFE 538
+P + Q ++S + +D + Q++ E EE +K ++ + E
Sbjct: 821 SPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAE 880
Query: 539 ALERKTKKDQEMQ-----LIHEISNLKNLVKHAEVYNQDLENELSSKVELLREK---EDQ 590
+R +K ++ + +S L+N K ++ N +E E + EL + ED
Sbjct: 881 TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDS 940
Query: 591 IKKLQEYIDSQKLENIKMD--LSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSEN 648
+K+LQ ++ LE +M +S + IE+ Q TL K +A L E
Sbjct: 941 LKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTL----------KEINASLNQEK 990
Query: 649 LELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV 708
+ L +K + A + E I Q + +K + + +E +A+ ++++ K
Sbjct: 991 MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN 1050
Query: 709 PKDLLCNLELEGKITDLQKELNKEVEE-NEAL-REEVILLSELKSLPSEVERLRKEIQDK 766
K L C L + T L + E+E+ EA +E L++L + L E++
Sbjct: 1051 SK-LECLLN---ECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETV 1106
Query: 767 SEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNF---- 822
+ L + ++ + +S GL +EI K++ Q QE +
Sbjct: 1107 QQAL------RSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVM 1160
Query: 823 KTLH----MDFEQKYKMVLEENERMNQ---------EIVNLSKEAQKFDSSLGALKTELS 869
KT H ++ E V E NQ E+ +S ++ +++ L L+ L
Sbjct: 1161 KTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS--YNAQLVQLEAMLR 1218
Query: 870 YKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE------ 923
K +LQE +E + +E++ ++ LE S LQ ++ ++ + + EE
Sbjct: 1219 NKELKLQESEKEKECLQHELQTIRGDLET--SNLQDMQSQEISGLKDCEIDAEEKYISGP 1276
Query: 924 ----------------VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLR 967
++T + ++L+++ E LQ E+ +L ++++D+ + I ++
Sbjct: 1277 HELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMA 1336
Query: 968 NALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEA---- 1023
+ L + +N + E+ ++ E + ++ + +D+ E
Sbjct: 1337 EEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLS 1396
Query: 1024 -KNTQTLTADVKDNEI-IEQQRKIF-----SLIQEKNELQQMLESVIAEKEQLKTDLKEN 1076
K Q A++++ + ++ + KI + + +ELQ ++S+ AE L T+L+ N
Sbjct: 1397 DKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLR-N 1455
Query: 1077 IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDR--------------- 1121
+ + + +L L ++ +V + + LS D
Sbjct: 1456 FQGDLVKEMQLGL-------EEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSL 1508
Query: 1122 LAEVEEKLKEKSQQLQEK-----QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEH 1176
L+ +E + + E Q++ L +E S K + E+E+L + +LE
Sbjct: 1509 LSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQ---SLEK 1565
Query: 1177 METERLELAQKLNENYEEVKSI-TKERKVLKELQKSFETERDH----LRGYIREIE---- 1227
+E + N+ +E++ + + ER+ L L+K + +E + L E+E
Sbjct: 1566 LEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLA 1625
Query: 1228 ATGLQTKE---ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ-DLEKSHTKLQEEIP 1283
A QT++ EL++A + L+ + L +E Q N D+ K HT E
Sbjct: 1626 AEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERT 1685
Query: 1284 VLHEEQELLPNVKEVSETQETMN-ELELLTEQSTTKDSTTLARIEMERLRLN----EKFQ 1338
H+ ++ + Q+ +N ++E +TE K + + + +K Q
Sbjct: 1686 PKHDVHQICDK-----DAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQ 1740
Query: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNM-KEKDN 1397
S E I L+ N + L + D I +++E+ ++ + L++ +++D
Sbjct: 1741 GSSECISELSFSGPNALVPMDFLGNQED-----IHNLQLRVKETSNENLRLLHVIEDRDR 1795
Query: 1398 ETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSE 1457
+ +++EM++ DS L E++++ + E + + KE DL E +
Sbjct: 1796 KVESLLNEMKEL---DSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCD 1852
Query: 1458 SDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETI--NELRVNLSEKETEISTIQKQLE 1515
+L + ++ ++ L ++ E+ K E I N +VN S KE + ++ +L
Sbjct: 1853 HQELLQRVE--TSEGLNSDLEMHAD----KSSREDIGDNVAKVNDSWKERFLD-VENELS 1905
Query: 1516 AINDKLQNKIQEIYEKEEQFNIKQISEV-QEKVNELKQFKEHRKAKDSALQSIESKMLEL 1574
I + + E E + Q ++ EK NE KQ + +E ++ +
Sbjct: 1906 RIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQ---------KVIVCLEEELSVV 1956
Query: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIV--AKMKESQEKEYQFLK 1632
T+ + + E+ M K+ + ++ E ++ + +L+ + E + ++ E++ KE L
Sbjct: 1957 TSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELL 2016
Query: 1633 MTAVNETQEKMCEIEHLKEQFET-----QKLNLENIETENIRLTQILHENLEEMRSVTKE 1687
T ++ E + + HL+E+ ++ Q L+L E EN QI N +E + KE
Sbjct: 2017 QTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELEN----QIAQLN-KEKELLVKE 2071
Query: 1688 RDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVS-- 1745
+ L++ E+ + + L + E L + + + I+KLR +
Sbjct: 2072 SESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD 2131
Query: 1746 -EKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH-------MHLKEQQETIDKLRGIV 1797
+K I+ K+ E ND+LK + ++ EL+++ + + + ++ L+ +
Sbjct: 2132 EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQI 2191
Query: 1798 SEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIK 1857
E L + DL ++ + ++++ + QL L K ++ + + E EQ + QIK
Sbjct: 2192 EEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIK 2251
Query: 1858 DQSLTLSKL---EIENLNLA---------------QKLHENLEE----MKSVMKERDNLR 1895
++S T ++ +++ LN A Q L +EE S+ K R L
Sbjct: 2252 EESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE 2311
Query: 1896 RVEETLKLERDQLKESLQET---KARDLEIQQELKTARMLSKEH--------KETVDKLR 1944
E+ QLKES K R +++EL+ AR ++EH K V+ L+
Sbjct: 2312 ADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIART-NQEHAALEAENSKGEVETLK 2370
Query: 1945 EKISEKTIQISDIQKDLDKSKDELQKKIQELQKK-----ELQLL----------RVKEDV 1989
KI T + ++ D+ + E + ELQK+ EL+++ + +E V
Sbjct: 2371 AKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKV 2430
Query: 1990 NMSHKKINEMEQLKKQFEA-------------------QNLSMQ--SVRMDNFQLTKKLH 2028
M K ME L+ Q + QNLS Q + ++ QL + L
Sbjct: 2431 QMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLD 2490
Query: 2029 ESLEEIRIVAKERDELRRIKESLKME---RDQFIATLREMIARDRQN----HQVKPEKRL 2081
E+ ++ + L + E K + +D+ I+ L+ I Q QV+ E +L
Sbjct: 2491 EAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQL 2550
Query: 2082 LSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQK--ELSMRVK 2139
+ L E +I+ L + + + D E L +LE E+E K ++S K
Sbjct: 2551 WKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEK 2610
Query: 2140 AN------LSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHE---- 2189
N L + +K + S E +R+ +L+ +L + K++ E
Sbjct: 2611 VNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLE 2670
Query: 2190 -SINKFEMDFI--DEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIE------ 2240
S K +D + D+VEK+ ++ +I Q ++ + L L+ N +E
Sbjct: 2671 NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE 2730
Query: 2241 -----EILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDR 2295
E + E +K+ +++ ++ K TQ LEE T+ D K N ++KEN+R
Sbjct: 2731 KLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENER 2790
Query: 2296 ICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLAS 2355
++ ++ + EE + KE Q L++ +EK
Sbjct: 2791 A-------QGKMKLLIKSCKQLEEEKEILQKELSQ-LQAAQEK----------------- 2825
Query: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESA---MHKESKIIKMQKELE 2412
Q T D K +LTTE I+EL+ +L E + A + K ++ ++LE
Sbjct: 2826 --QKTGTVMDTK-------VDELTTE-IKELKETLEEKTKEADEYLDKYCSLLISHEKLE 2875
Query: 2413 VTNDIIAKLQAKVHESNKCLEKTKETIQ--VLQDKVALGAKPYKEEIED-LKMKLVKIDL 2469
AK + ++ C +++K+ + L V G P E L K
Sbjct: 2876 K-----AKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASG 2930
Query: 2470 EKMKNAKEFEKEISATKATVE-YQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPL 2528
++ +++ +E T AT E + K+ + + + A+DT E T+ +P P
Sbjct: 2931 KRQRSSGIWENGRGPTPATPESFSKKSKKAVMSGI---HPAEDT----EGTEFEPEGLPE 2983
Query: 2529 TCGGGSGIVQ--NTKALILKSEHI--RLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEV 2584
G + T IL+ + R ++ K L K L +++ +
Sbjct: 2984 VVKKGFADIPTGKTSPYILRRTTMATRTSPRLAAQKLALSPLSLGKENLAESSKPTAGGS 3043
Query: 2585 KTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCF 2644
++ K + +R SP +GT ++ T NL + P +SP+
Sbjct: 3044 RSQKVKVAQR-------------SPVDSGTILREP--TTKSVPVNNLPERSPTDSPREGL 3088
Query: 2645 FDSRSKSLPSP 2655
R + +PSP
Sbjct: 3089 RVKRGRLVPSP 3099
Score = 238 bits (608), Expect = 5e-62
Identities = 496/2579 (19%), Positives = 1048/2579 (40%), Gaps = 454/2579 (17%)
Query: 306 CTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLE 365
C F LT Q+ S +KY E L ++Y KE+ + K+ LE
Sbjct: 142 CNTPQKIFTTPLTPSQYYSGSKY-------------EDLKEKYNKEVEERKR------LE 182
Query: 366 TRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCL 425
+A++ + +Q L + + + ++ R +SS + QQE
Sbjct: 183 AEVKALQAKKASQTLPQATMNHR-------DIARHQASSSVFSWQQE------------- 222
Query: 426 GKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWN 485
P+++++ + + I R+ S S + + TL + +
Sbjct: 223 ---------------KTPSHLSSNSQRTPIR--RDFSASYFSGEQEVTPSRSTLQIGKRD 265
Query: 486 PATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKE-----KNDLDEFEAL 540
+ + + L+ L+A ++LR + E+EL+L+ K +++F+ L
Sbjct: 266 ANSSFFDNSSSPHLLDQLKAQN-------QELRNKINELELRLQGHEKEMKGQVNKFQEL 318
Query: 541 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS 600
+ + +K +++LI E + N + V ++ S+K L +K +KKL E +
Sbjct: 319 QLQLEK-AKVELI-EKEKVLNKCRDELVRTTAQYDQASTKYTALEQK---LKKLTEDLSC 373
Query: 601 QKLENIKMDLSYSLESIEDPKQMKQTL---------FDAETVALDAKRESAFLRSENLE- 650
Q+ S + E K+ ++ L D E + + A+ +++N+
Sbjct: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
Query: 651 -LKEKMKELATTYKQMENDIQLYQSQL-EAKKKMQVDL--EKELQSAFNEITKLTSLIDG 706
L+ ++ +L + +Q+EN+++ ++ +L A++ Q E EL+ + E+ K +L+
Sbjct: 434 VLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKS 493
Query: 707 KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
+ LE ++ ++++ LN+ E E+K+ + E + +++Q+K
Sbjct: 494 HSEQKAREVCHLEAELKNIKQCLNQSQNFAE----------EMKAKNTSQETMLRDLQEK 543
Query: 767 -SEELHIITSEKDKLFSEVVHK------------ESRVQGLLEEIGKTKDDLATTQSNYK 813
+++ + +T EK KL + K E ++ L +++ KT+ + S +
Sbjct: 544 INQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE 603
Query: 814 STDQEFQNFKTLHMDFEQK--YKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYK 871
+E++ K E+K + ENE++ + + E + S + L+T L K
Sbjct: 604 LKKKEYEELK------EEKTLFSCWKSENEKL---LTQMESEKENLQSKINHLETCL--K 652
Query: 872 TQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEK 931
TQ++ K+ E ER+ +E +E L L V K++ E + E++ +
Sbjct: 653 TQQI--KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFS 710
Query: 932 DDLKQLQ-ESLQIERDQLKSDIHDTVN----MNIDTQEQLRNALESLKQHQETINTLKSK 986
D Q + E++ ++ QL + D + ++ + ++ R + +++ + LKSK
Sbjct: 711 DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770
Query: 987 ISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ------TLTADVKDNEI-I 1039
+ V T ++ Q+ ++ D++ + ++ ++ + +
Sbjct: 771 DASLV------------TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEA 818
Query: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE--MTIENQEELRLLGDELKKQ 1097
+Q K +++Q + + LE + ++Q+ +DL++ E + I+ + E L+ E +
Sbjct: 819 DQSPKNSAILQNRVD---SLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAE-QMH 874
Query: 1098 QEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI 1157
Q VA+ K + + S + +AE L+ K ++LQ ++ Q E+ E+ KK
Sbjct: 875 QSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQEL-KKS 933
Query: 1158 NEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERD 1217
N + L++ LK +L E + E+ E++ ++ N E++ +T+E LKE+ S E+
Sbjct: 934 NHL--LEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKM 991
Query: 1218 HL-------RGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE--KTAQIIN- 1267
+L YI E E + + ++ K + L + E +S+ K AQ N
Sbjct: 992 NLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNS 1051
Query: 1268 ---------TQDLEKSHTKLQE-EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTT 1317
T E +L++ + E QE L + E + + LEL T Q
Sbjct: 1052 KLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNL-MLELETVQQAL 1110
Query: 1318 KDSTT---------LARIEMERLRLNEKFQESQEEIKSLTKERDNL----KTIKEALEVK 1364
+ T ++ E + L E+ + Q+E+ L +E + L KT E ++
Sbjct: 1111 RSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLE 1170
Query: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424
+ ++ ++E ++ + K + L +KE ++ ++ L+++E +
Sbjct: 1171 SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS------------YNAQLVQLEAMLR 1218
Query: 1425 GLSKRLQESHDEMKSVAKE----KDDLQ--RLQEVLQSESDQLKENIKEIVAKHLETEEE 1478
+LQES E + + E + DL+ LQ++ E LK+ + K++ E
Sbjct: 1219 NKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHE 1278
Query: 1479 LKVA-------HCCLKEQEETINELR--------------VNLSEKETEISTIQKQLEAI 1517
L + C L+ +NEL L++ +E T +++
Sbjct: 1279 LSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEE 1338
Query: 1518 NDKLQNKIQEIYEKEEQFNIKQISEVQ-----EKVNE-----LKQFKEHRKAKDSALQSI 1567
KL N+++ + + + + + ++ E+ NE L E + L
Sbjct: 1339 VGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDK 1398
Query: 1568 ESKM--LELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ- 1624
E +M EL + Q E +I+ + +M LQ D LK + ++ Q
Sbjct: 1399 EVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQG 1458
Query: 1625 --EKEYQFLKMTAVNETQEKMCEIEH--------------LKEQFETQKL--NLENIETE 1666
KE Q + + C + L EQ L NLE +
Sbjct: 1459 DLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSA 1518
Query: 1667 N------IRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQ 1720
N + + + ENL + + + +E +V R L++ + ++ + K
Sbjct: 1519 NQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKN 1578
Query: 1721 EELKIVHMHLKEHQETIDKLR-GIVSEK---TNEISNMQKDLEHSNDALKAQDLKIQEEL 1776
+E++ + L ++ +D LR +SE +++++ ++E A K Q ++ EL
Sbjct: 1579 KEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLEL 1638
Query: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQEL-KANEHQLI-- 1833
+A + L+ + L GI +E D + + + S E + K + HQ+
Sbjct: 1639 EVARLQLQGLDLSSRSLLGIDTE--DAIQGRNESCDISKEHTSETTERTPKHDVHQICDK 1696
Query: 1834 TLKKDVNETQKKVSEMEQLK---------------------------------------- 1853
++D+N +K++E +K
Sbjct: 1697 DAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNA 1756
Query: 1854 ----------KQIKDQSLTLSKLEIENLNLAQKLHE---NLEEMKSVMKERDN------- 1893
+ I + L + + ENL L + + +E + + MKE D+
Sbjct: 1757 LVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEV 1816
Query: 1894 -----------LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDK 1942
L ++ LK E L E L+ E+ Q ++T+ L+ + + DK
Sbjct: 1817 QLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADK 1876
Query: 1943 LREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQL 2002
+ DI ++ K D +++ +++ EL +R E ++ H+ + L
Sbjct: 1877 SSRE---------DIGDNVAKVNDSWKERFLDVE-NELSRIR-SEKASIEHEAL----YL 1921
Query: 2003 KKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMER---DQFI 2059
+ E + DN K + EE+ +V ER++LR +++ + DQ
Sbjct: 1922 EADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLS 1981
Query: 2060 ATLREMIARDRQNHQ-------------VKPEKRLLSDGQQHLTESLREKCSRIKELLKR 2106
++E ++ ++HQ VK + LL ++E L++K L ++
Sbjct: 1982 EKMKEK-TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDK----THLQEK 2036
Query: 2107 YSEMDDHYECLNRLSLDLEKEI-EFQKELSMRVKANLSL-PYLQTKHIEKLFTANQRCSM 2164
++ + L+ +LE +I + KE + VK + SL L EKL N ++
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKL---NVSKAL 2093
Query: 2165 EFHRIMKKLKYVLSYVTKIKEEQHE---SINKFEMDFIDEVEKQKELLIKIQHLQQDCDV 2221
E +++K ++ L ++ +EE H+ I K + + +KQ + K++ +++ D
Sbjct: 2094 E-AALVEKGEFALR-LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS 2151
Query: 2222 PSRELRDLKLNQNMDLHIEEIL---KDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNT 2278
++ +L+ M +E++ + S++E ++KT+ +++ + + F + +
Sbjct: 2152 LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEM---ARSLKVFELDLVTL 2208
Query: 2279 RFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFE----ERSATISKEWEQDLKS 2334
R + E L IQ++ ++ +++ ++ +++ E + E E S T + + LK
Sbjct: 2209 RSEKENLTKQIQEKQGQLSELDKLLSS-FKSLLEEKEQAEIQIKEESKTAVEMLQNQLKE 2267
Query: 2335 LKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN---KNPHVTSRATQLTTEK-----IREL 2386
L E L + + +K A+ ++P ++ +N RA EK +++L
Sbjct: 2268 LNEAVAALCGDQEIMK---ATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQL 2324
Query: 2387 ENSLHEA-----KESAMHKESKIIKMQKE---LEVTND--IIAKLQAKVHESNKCLEKTK 2436
+ S H A + + +E +I + +E LE N + L+AK+ + L +
Sbjct: 2325 KESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLE 2384
Query: 2437 -ETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFE---------------- 2479
+ + + +K L + KE+ +++++ E + KE E
Sbjct: 2385 LDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQ 2444
Query: 2480 ---KEISATKATVEYQKEVIRLLRENLRRSQQA--QDTSVISEHTDPQPSNKPLTCGGGS 2534
KE++ A + +E + +NL + + + + + D +N + +
Sbjct: 2445 TQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN 2504
Query: 2535 GIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLK 2593
G++Q + K E + ++EIS+LK Q I+ + +L+S + E + WKE+ L+
Sbjct: 2505 GLIQEVEDGKQKLE--KKDEEISRLKNQ----IQDQEQLVSKLSQVEGEHQLWKEQNLE 2557
Score = 214 bits (546), Expect = 7e-55
Identities = 438/2180 (20%), Positives = 906/2180 (41%), Gaps = 319/2180 (14%)
Query: 590 QIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQ-MKQTLFDAETVALDAKRESAFLRSEN 648
+I++L+ +D KL+ K + L+S+E Q KQ + + +T + KRE+ L
Sbjct: 19 KIQELEGQLD--KLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
Query: 649 LELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV 708
L++ ++++ + E+ + + QL + KK LE+EL+ +E+ +
Sbjct: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
Query: 709 PKDLLCNLELE--------------GKITDLQKELNKEVEENEALREEVILLSELK---S 751
CN + K DL+++ NKEVEE + L EV L K +
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196
Query: 752 LPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSN 811
LP + ++I + + +++K S + R + D + ++
Sbjct: 197 LP-QATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRT--------PIRRDFS---AS 244
Query: 812 YKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYK 871
Y S +QE ++ ++ +N + L + Q+ + + L+ L
Sbjct: 245 YFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGH 304
Query: 872 TQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEK 931
+E++ + + QE ++E+ K +L ++ L E T + Q + L Q+
Sbjct: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQK- 363
Query: 932 DDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL-------K 984
LK+L E L +R +S ++ +E+ + E L + Q + TL K
Sbjct: 364 --LKKLTEDLSCQRQNAES---ARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMK 418
Query: 985 SKISEEV--SRNLH------------MEENTGETKDEFQQKMVGID--------KKQDL- 1021
+++++E+ ++N+H +++ +EF+QK+ + K+ +L
Sbjct: 419 ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELR 478
Query: 1022 ----EAKNTQTLT---ADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAE---KEQLKT 1071
E K L ++ K E+ + ++ ++ Q N+ Q E + A+ +E +
Sbjct: 479 RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538
Query: 1072 DLKENIEMTIENQ---EELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEK 1128
DL+E I EN E+L+L +L+KQ++ ++ K+E + + D+L++ E++
Sbjct: 539 DLQEKINQQ-ENSLTLEKLKLAVADLEKQRDC---SQDLLKKREHHIEQLNDKLSKTEKE 594
Query: 1129 LKEKSQQLQEKQQQLLNVQEE-------MSEMQKKINEIENLKNELKNKELTLEHMETER 1181
K L+ K+++ ++EE SE +K + ++E+ K L++K + H+ET
Sbjct: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK---INHLETCL 651
Query: 1182 LELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAH 1241
K +E E V+++ +R + L + L E+E L E + A
Sbjct: 652 KTQQIKSHEYNERVRTLEMDR---ENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAE 708
Query: 1242 IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEI-------PVLHEEQELLPN 1294
++HQ+ I+ + S+ T Q+ +DLE L EI LH E E L +
Sbjct: 709 FSDQKHQKEIENMCLKTSQLTGQV---EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRD 765
Query: 1295 VKEVSETQETMNE-------------------LELLTEQSTTKDSTTLARIEMERLRLN- 1334
+ + + NE ++ EQ + + R+E ++ N
Sbjct: 766 LLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNS 825
Query: 1335 ----------EKFQESQEEIKS-LTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ 1383
E ESQ+++ S L K+ + L IK +E + ++ + +A+ +
Sbjct: 826 AILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRI 885
Query: 1384 SKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL--RIEIEMLGLSKRLQESHDEMKSVA 1441
SK ++ + + N + +S +E K K+ LL ++E E + + L++S+ ++
Sbjct: 886 SKLQEDTSAHQ--NVVAETLSALEN-KEKELQLLNDKVETEQAEI-QELKKSNHLLEDSL 941
Query: 1442 KEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLS 1501
KE LQ L E L E K+ + I++ + EEL + LKE ++N+ ++NL
Sbjct: 942 KE---LQLLSETLSLE----KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLI 994
Query: 1502 EKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD 1561
+K + + E K +++ + Y++E+ +++ E +L Q + + K+
Sbjct: 995 QKSESFANYIDERE----KSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN 1050
Query: 1562 SALQSIESKMLEL-TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM 1620
S L+ + ++ L NR E ++ + KE +E + A ER+Q +
Sbjct: 1051 SKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF-LTKLAFAEERNQ----------NL 1099
Query: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680
E Q L+ + E LK++ T K ++ E + +L EN E+
Sbjct: 1100 MLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKE---VNDLLQEN-EQ 1155
Query: 1681 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL 1740
+ V K + + +++E + R+ +KE E + + Q +L++ + L + + +L
Sbjct: 1156 LMKVMKTKHECQNLES--EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQL 1213
Query: 1741 RGIVSEKTNEISNMQKD---LEHSNDALKA-------QDLKIQEELRIAHMHLKEQQETI 1790
++ K ++ +K+ L+H ++ QD++ QE + + +++ I
Sbjct: 1214 EAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYI 1273
Query: 1791 DKLRGIVSEKTDKLSNMQKDLENSNAKLQ--EKIQE-LKANEHQLITLKKD-----VNET 1842
+ + + D +++Q L+ + KL EKI E L+A +++L+T D + T
Sbjct: 1274 SGPHELSTSQNDN-AHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITAT 1332
Query: 1843 QKKVSEMEQLKKQIK---DQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEE 1899
+K E+ +L ++K D S L +E++ + + E+ + D E
Sbjct: 1333 RKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEH 1392
Query: 1900 TLKLERDQLKESLQETKARDLEIQQELKT-----ARMLSK--EHKETVDKLREKISEKTI 1952
L L +++ E + + L +Q E K +M SK E + VD L+ + +
Sbjct: 1393 -LTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLST 1451
Query: 1953 QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE-----MEQLKKQFE 2007
+ + Q DL K E+Q ++E L V + ++S + +EQ
Sbjct: 1452 NLRNFQGDLVK---EMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSL 1508
Query: 2008 AQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKER--------DELRRIKESLKMERDQFI 2059
NL +V + + + SL+E + KE +EL ESL Q +
Sbjct: 1509 LSNLE-GAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEEL----ESLCEVYRQSL 1563
Query: 2060 ATLREMIARD--RQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECL 2117
L E + +N +++ ++LLS +Q L C R + L SE + + L
Sbjct: 1564 EKLEEKMESQGIMKNKEIQELEQLLSSERQEL------DCLRKQYL----SENEQWQQKL 1613
Query: 2118 NRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVL 2177
++L++E ++ +K+ + ++ L + LQ + ++ ++ ++ ++
Sbjct: 1614 TSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLD--LSSRSLLGIDTEDAIQGRNESC 1671
Query: 2178 SYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL 2237
+ E E K ++ I + + Q++L + I+ + + V + + Q+ D
Sbjct: 1672 DISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAV--KPTGECSGEQSPDT 1729
Query: 2238 HIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQK---END 2294
+ E +D ++ +E LS ++L + DI L+ +++ EN
Sbjct: 1730 NYEPPGEDKTQG-----SSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENL 1784
Query: 2295 RICQVNNFFNNRIIAIMNESTEFEER----------SATISKEWEQDLKSLKEKNEKLFK 2344
R+ V + ++ +++NE E + + E E+ + LK++N L +
Sbjct: 1785 RLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSE 1844
Query: 2345 N-----------YQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLT---TEKIRELENSL 2390
Q ++TS + + + + ++ E+ ++EN L
Sbjct: 1845 KLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENEL 1904
Query: 2391 HEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKE----TIQVLQDKV 2446
+ E + + ++ +LEV V CLEK E I L++++
Sbjct: 1905 SRIRSEKASIEHEALYLEADLEV-----------VQTEKLCLEKDNENKQKVIVCLEEEL 1953
Query: 2447 ALGAKPYKE---EIEDLKMKLVKID--LEKMK-NAKEFEKE-------ISATKATVEYQK 2493
++ + E++ + K +D EKMK +E E I +A V+ +
Sbjct: 1954 SVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT 2013
Query: 2494 EVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLE 2553
E+++ L ++ S+ +D + + E + ++++AL L LE
Sbjct: 2014 ELLQTLSSDV--SELLKDKTHLQEKL--------------QSLEKDSQALSLTK--CELE 2055
Query: 2554 KEISKLKQQNEQLIKQKNEL 2573
+I++L ++ E L+K+ L
Sbjct: 2056 NQIAQLNKEKELLVKESESL 2075
Score = 178 bits (451), Expect = 7e-44
Identities = 362/1756 (20%), Positives = 731/1756 (41%), Gaps = 238/1756 (13%)
Query: 873 QELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD 932
Q++QE ++ + E +Q + QL++ ++ LQ + +K++ E L +E
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQK-------QKVENEKTEGTNLKRENQ 70
Query: 933 DLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKI--SEE 990
L ++ ESL+ + ++ ++ + + QL + + +++ ++ + KS++ S++
Sbjct: 71 RLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ 130
Query: 991 VSRNLHMEENTGETKDEF------------QQKMVGIDKKQDLEAKNTQTLTADVKDNEI 1038
+++ + N T + K + +K + E + + L A+VK +
Sbjct: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQA 190
Query: 1039 IEQQRKIFSLIQEKNEL--QQMLESVIA-EKEQLKTDLKENIEMTIENQEELRLLGDELK 1095
+ + + ++ Q SV + ++E+ + L N + T ++
Sbjct: 191 KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD---FSASYFS 247
Query: 1096 KQQEIVAQEKNHAIKKEGELSRTCDRLA--EVEEKLKEKSQQLQEKQQQL-LNVQEEMSE 1152
+QE+ I K S D + + ++LK ++Q+L+ K +L L +Q E
Sbjct: 248 GEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKE 307
Query: 1153 MQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKE----------- 1201
M+ ++N+ + L +L LE + E +E + LN+ +E+ T +
Sbjct: 308 MKGQVNKFQEL-------QLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL 360
Query: 1202 RKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEK 1261
+ LK+L + +R + +E + KE+ K L Q + L + +
Sbjct: 361 EQKLKKLTEDLSCQRQNAESARCSLEQ---KIKEKEKEFQEELSRQQRSFQTLDQECIQM 417
Query: 1262 TAQIINTQDLEKS---HTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTK 1318
A++ TQ+L+++ H LQ E+ L ++ L N + E ++ + E + S K
Sbjct: 418 KARL--TQELQQAKNMHNVLQAELDKLTSVKQQLEN--NLEEFKQKLCRAEQAFQASQIK 473
Query: 1319 DSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHD-----QLKEHIR 1373
++ +E + N S+++ + + LK IK+ L + + K +
Sbjct: 474 ENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQ 533
Query: 1374 ETLAK-IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR---IEIEMLG--LS 1427
ET+ + +QE ++QE SL ++ + V+++E+ + LL+ IE L LS
Sbjct: 534 ETMLRDLQEKINQQENSLTLE----KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589
Query: 1428 KRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEE-ELKVAH--C 1484
K +ES + ++ +K + + L+E S EN K + E E + K+ H
Sbjct: 590 KTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLET 649
Query: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
CLK Q+ +E + E + + ++ +++ L +K E+ ++ + E+Q
Sbjct: 650 CLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAY-----MELQ 704
Query: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI 1604
+K +F + + K+ ++++ K +LT ++++ + ++Q++ E + R + L
Sbjct: 705 QKA----EFSDQKHQKE--IENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHA 758
Query: 1605 ERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEI--EHLKEQFETQKLNLEN 1662
E + L++ K A + +++ + L I E E + LE
Sbjct: 759 EYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEA 818
Query: 1663 IET-ENIRLTQILHENLE-EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQ 1720
++ +N + Q ++LE + S + DL+ E L + +++ENL + + Q
Sbjct: 819 DQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKA---EQMHQ 875
Query: 1721 EELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH 1780
+ + + QE + +V+E + + N +K+L+ ND ++ + +IQE + H
Sbjct: 876 SFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH 935
Query: 1781 M---HLKEQQ---ETID----KLRGIVS---EKTDKLSNMQKDLENSNAKL-QEKIQELK 1826
+ LKE Q ET+ ++ I+S + ++L+ L+ NA L QEK+ ++
Sbjct: 936 LLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
Query: 1827 ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS 1886
+E + ++E +K +SE L Q K + L L ++ +E+L +
Sbjct: 996 KSE----SFANYIDEREKSISE---LSDQYKQEKLIL----LQRCEETGNAYEDLSQKYK 1044
Query: 1887 VMKERDNLRRVEETLKLERDQLKE--SLQETKARDLEIQQELKTARMLSKEHKETVDKL- 1943
+E+++ KLE L E SL E + +LE +LK A +KEH+E + KL
Sbjct: 1045 AAQEKNS--------KLE-CLLNECTSLCENRKNELE---QLKEA--FAKEHQEFLTKLA 1090
Query: 1944 --REKISEKTIQISDIQKDL-DKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEME 2000
E+ +++ +Q+ L + D E + +++ +KE+ N K++N++
Sbjct: 1091 FAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLL 1150
Query: 2001 QLKKQFEAQNLSMQSVRMDNFQLTKKLHE----SLEEIRIVAKERDELRRIKESLKMERD 2056
Q +Q ++ K HE E IR KER E R + + K + D
Sbjct: 1151 QENEQL--------------MKVMKTKHECQNLESEPIRNSVKER-ESERNQCNFKPQMD 1195
Query: 2057 QFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMD----- 2111
+ + I+ D N Q+ + +L + + L ES +EK EL +++
Sbjct: 1196 LEV----KEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQ 1251
Query: 2112 ----DHYECLNRLSLDL-EKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEF 2166
L +D EK I ELS N L + KL + C
Sbjct: 1252 DMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKIC---- 1307
Query: 2167 HRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDC------- 2219
I++ KY L VT++ + + E I +EV K LL +++ L D
Sbjct: 1308 -EILQAEKYEL--VTELNDSRSECITA-TRKMAEEVGK---LLNEVKILNDDSGLLHGEL 1360
Query: 2220 --DVPSRE---------------LRDLKLNQNMDLHIEEILKDFSE--SEFPSIKTEFQQ 2260
D+P E L + +++ L +E+ F+E +F S+++E +
Sbjct: 1361 VEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKI 1420
Query: 2261 VLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEER 2320
+ +M+ + E L T D K +N + N R F ++ M E E
Sbjct: 1421 LHDQHCQMSSKMSE-LQTYVDSLKAENLVLSTNLR------NFQGDLVKEMQLGLE-EGL 1472
Query: 2321 SATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTT 2380
++S D SL + F Y+ L + ++ N V++ +
Sbjct: 1473 VPSLSSSCVPDSSSLSSLGDSSF--YRALLEQTGDMSLLS-----NLEGAVSANQCSVDE 1525
Query: 2381 EKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHE----SNKCLEKTK 2436
L+ KE+ + +++ EV + KL+ K+ NK +++ +
Sbjct: 1526 VFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE 1585
Query: 2437 ETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVE---YQK 2493
+ + + ++ K Y E E + KL + L E E +++A K E +
Sbjct: 1586 QLLSSERQELDCLRKQYLSENEQWQQKLTSVTL-------EMESKLAAEKKQTEQLSLEL 1638
Query: 2494 EVIRLLRENLRRSQQA 2509
EV RL + L S ++
Sbjct: 1639 EVARLQLQGLDLSSRS 1654
Score = 162 bits (410), Expect = 4e-39
Identities = 288/1446 (19%), Positives = 585/1446 (40%), Gaps = 221/1446 (15%)
Query: 1111 KEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNK 1170
KEG +R ++ E+E +L + ++ Q++Q QL +++ + +QK+ ++EN K E N
Sbjct: 9 KEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLE---AALQKQKQKVENEKTEGTNL 65
Query: 1171 ELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230
+ E +RL ++ E+ E+ K +KE Q +F + L ++IE
Sbjct: 66 K-----RENQRL---MEICESLEKTKQKISHELQVKESQVNF--QEGQLNSGKKQIE--- 112
Query: 1231 LQTKEELKIAHIHLKEHQETIDELRRSVSE-KTAQIINT--------------QDLEKSH 1275
+ ++ELK L+ Q+ S++ T Q I T +DL++ +
Sbjct: 113 -KLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKY 171
Query: 1276 TKLQEEIPVLHEEQELLPNVKEVSET--QETMNELELLTEQSTTKD------------ST 1321
K EE L E + L K+ S+T Q TMN ++ Q+++ S+
Sbjct: 172 NKEVEERKRLEAEVKAL-QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSS 230
Query: 1322 TLARIEMERLRLNEKFQESQEEIKSLTK----ERDNLKTIKEALEVKH--DQLKEHIRET 1375
R + R F QE S + +RD + + H DQLK +E
Sbjct: 231 NSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQEL 290
Query: 1376 LAKIQESQSK-QEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434
KI E + + Q MK + N+ ++ ++E+ K +E++ K L +
Sbjct: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAK----------VELIEKEKVLNKCR 340
Query: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ-EETI 1493
DE+ + D L+ + +L E++ + + A C L+++ +E
Sbjct: 341 DELVRTTAQYDQASTKYTALEQKLKKLTEDLS-------CQRQNAESARCSLEQKIKEKE 393
Query: 1494 NELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEE--QFNIKQISEVQEKV-NEL 1550
E + LS ++ T+ ++ + +L ++Q+ Q + +++ V++++ N L
Sbjct: 394 KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNL 453
Query: 1551 KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK 1610
++FK+ + A Q+ + K EL ++E ++E ++ E+ + +E +E +
Sbjct: 454 EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ--KAREVCHLEAE--L 509
Query: 1611 ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRL 1670
+N K+ + + + E +M A N +QE M + L+E+ Q+ +L
Sbjct: 510 KNIKQCLNQSQNFAE------EMKAKNTSQETM--LRDLQEKINQQENSL---------- 551
Query: 1671 TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITR-DLEKQEELKIVHMH 1729
LE+++ + + R + L +R+ E L + +++ + E + L + +
Sbjct: 552 ------TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK 605
Query: 1730 LKEHQETIDKL----------RGIVSEKTNEISNMQKDLEHSNDALKAQDLK---IQEEL 1776
KE++E ++ ++++ +E N+Q + H LK Q +K E +
Sbjct: 606 KKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERV 665
Query: 1777 RIAHMHLKEQQETIDKLRGIVSEK-----TDKLSNM-------------QKDLENSNAKL 1818
R M + I L ++ K T KL+ M QK++EN K
Sbjct: 666 RTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKT 725
Query: 1819 QEKIQELKANEHQLITLKKDVNET----QKKVSEMEQLKKQIKDQSLTLSKLEIENLNL- 1873
+ +++ EH+L L ++ + Q +E E L+ +K + +L E +L
Sbjct: 726 SQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLL 785
Query: 1874 ----AQKLHEN----LEEMKSVMKERDNLR-------RVEETLKLERDQLKESLQETKAR 1918
+H + + E S+ ER R + L+ D L+ SL+ K
Sbjct: 786 AFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQM 845
Query: 1919 DLEIQQELKTARMLSKEHKETVDKLREK----ISEKTIQISDIQKDLDKSKDELQKKIQE 1974
+ ++Q++ + + E +E + K + ++E + +IS +Q+D ++ + + +
Sbjct: 846 NSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSA 905
Query: 1975 LQKKELQLLRVKEDVNMSHKKINEMEQ----LKKQFEAQNLSMQSVRMDNFQLTKKLHES 2030
L+ KE +L + + V +I E+++ L+ + L +++ ++ +++ + +
Sbjct: 906 LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN 965
Query: 2031 LEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLT 2090
EI + +E L+ I SL E+ I + N+ + EK + Q+
Sbjct: 966 KREIEELTQENGTLKEINASLNQEKMNLIQK-----SESFANYIDEREKSISELSDQYKQ 1020
Query: 2091 ESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANL----SLPY 2146
E L LL+R E + YE DL ++ + +E + +++ L SL
Sbjct: 1021 EKL--------ILLQRCEETGNAYE-------DLSQKYKAAQEKNSKLECLLNECTSLCE 1065
Query: 2147 LQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQK 2206
+ +E+L A + EF + KL + + E + D K
Sbjct: 1066 NRKNELEQLKEAFAKEHQEF---LTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSK 1122
Query: 2207 E----LLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVL 2262
L +I L+++ + +E+ DL + + + + E I+ ++
Sbjct: 1123 SEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERE 1182
Query: 2263 SNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTE---FEE 2319
S R + + D+E + + N ++ Q+ N+ + + E +
Sbjct: 1183 SERNQCN------FKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQH 1236
Query: 2320 RSATISKEWE---------QDLKSLK----EKNEKLFKNYQTLKTSLASGA--QVNPTTQ 2364
TI + E Q++ LK + EK L TS A Q + T
Sbjct: 1237 ELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTT 1296
Query: 2365 DNKNPHVTSRATQLTTEK---IRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKL 2421
NK + L EK + EL +S E + ++ K+ E+++ ND L
Sbjct: 1297 MNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLL 1356
Query: 2422 QAKVHE 2427
++ E
Sbjct: 1357 HGELVE 1362
Score = 134 bits (338), Expect = 9e-31
Identities = 238/1196 (19%), Positives = 510/1196 (42%), Gaps = 188/1196 (15%)
Query: 1530 EKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI 1589
E +E + + ++QE +L + K+ ++ + L S+E+ + + +++ + E +
Sbjct: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
Query: 1590 KEKEEMKRVQEALQIERDQLKE--NTKEIVAKMKESQEKEYQFLKMTAVNETQEKMC--E 1645
+E + + + E+L+ + ++ KE +E Q + K E + K C E
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK--KQIEKLEQELKRCKSE 124
Query: 1646 IEHLKEQFETQKLNLENIETENIRLTQIL----------HENLEEMRSVTKERDDLRSVE 1695
+E ++ ++ ++L T T L +E+L+E KE ++ + +E
Sbjct: 125 LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKE--KYNKEVEERKRLE 182
Query: 1696 ETLK-VERDQLKENLRETIT--RDLEKQEELKIVH--------MHLKEHQETIDKLRGIV 1744
+K ++ + + L + RD+ + + V HL + + R
Sbjct: 183 AEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS 242
Query: 1745 S-------EKTNEISNMQ-------------KDLEHSNDALKAQDLKIQEELRIAHMHLK 1784
+ E T S +Q H D LKAQ+ +++ ++ + L+
Sbjct: 243 ASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQ 302
Query: 1785 EQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQK 1844
++ +++G + +K +Q LE + +L EK + L +L+ ++
Sbjct: 303 GHEK---EMKG----QVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQAST 355
Query: 1845 KVSEMEQ-LKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKL 1903
K + +EQ LKK +D S E +L QK+ E +E + +E +R +TL
Sbjct: 356 KYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQ---EELSRQQRSFQTLDQ 412
Query: 1904 ERDQLK----ESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKI--SEKTIQISDI 1957
E Q+K + LQ+ K +Q EL + ++ + +++ ++K+ +E+ Q S I
Sbjct: 413 ECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQI 472
Query: 1958 -QKDLDKSKDELQKKIQEL----QKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLS 2012
+ +L +S +E++K+ L ++K ++ ++ ++ + +N+ + ++ +A+N S
Sbjct: 473 KENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTS 532
Query: 2013 MQSVRMDNFQLTKKLHE-----SLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIA 2067
+++ D L +K+++ +LE++++ + ++ R + L +R+ I L + ++
Sbjct: 533 QETMLRD---LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589
Query: 2068 RDRQNHQVKPEKRLLS--DGQQHLTESLRE--------KCSRIKELLKRYSEMDDHYECL 2117
+ K K LLS + ++ E L+E K K L + SE ++ +
Sbjct: 590 KTE-----KESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI 644
Query: 2118 NRLSLDLEKEIEFQKELSMRVKA------NLSLPYLQTKHIEKLFTANQRCSMEFHRIMK 2171
N L L+ + E + RV+ NLS+ I L S+E +
Sbjct: 645 NHLETCLKTQQIKSHEYNERVRTLEMDRENLSV------EIRNLHNVLDSKSVEVE--TQ 696
Query: 2172 KLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKL 2231
KL Y+ +++++ S K + + + K +L +++ L+ + S E+ D K
Sbjct: 697 KLAYM-----ELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD-KD 750
Query: 2232 NQNMDLHIE-EILKDFSESEFPSIKT--EFQQVL---SNRKEMTQFLEEWLNTRFDIEKL 2285
DLH E E L+D +S+ S+ T + Q+ L + M + + +
Sbjct: 751 RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810
Query: 2286 KNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKN 2345
++ + E D+ + + NR+ ++ ++ ++ + K+ E+ ++ E E L K
Sbjct: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKA 870
Query: 2346 YQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII 2405
Q ++ +A +Q Q++ + H + E + LEN
Sbjct: 871 EQMHQSFVAETSQRISKLQEDTSAH-----QNVVAETLSALENK---------------- 909
Query: 2406 KMQKELEVTNDIIAKLQAKVHE---SNKCLEKTKETIQVLQDKVALGAKPY-------KE 2455
+KEL++ ND + QA++ E SN LE + + +Q+L + ++L K K
Sbjct: 910 --EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKR 967
Query: 2456 EIED-------LKMKLVKIDLEKM---KNAKEF-----EKEISATKATVEYQKEVIRLLR 2500
EIE+ LK ++ EKM + ++ F E+E S ++ + +Y++E + LL+
Sbjct: 968 EIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQ 1027
Query: 2501 ENLRRSQQAQDTSVISEHTDPQPSNKPLTC--GGGSGIVQNTKALI------LKSEHIRL 2552
+D S ++ Q N L C + + +N K + EH
Sbjct: 1028 RCEETGNAYEDLS--QKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
Query: 2553 EKEISKLKQQNEQLIKQ--------KNELLSNNQHLSNEVKTWKER--TLKREAHK 2598
+++ +++N+ L+ + ++E+ N + +E K+ TLK E +K
Sbjct: 1086 LTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 268 bits (686), Expect = 4e-71
Identities = 491/2491 (19%), Positives = 1057/2491 (42%), Gaps = 345/2491 (13%)
Query: 320 LQFASTAKYMKNTPYV-NEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQL-- 376
L+ A + ++T ++ NE+ E L++ +E+ D++K+LE+ A+ ++
Sbjct: 98 LEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAEN 157
Query: 377 --AQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNS 434
++L E L+K + +++ + + Q+E R+ + +++K
Sbjct: 158 ENSKLRRENKRLKKKNEQLCQDI---IDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYE 214
Query: 435 --NYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLN 492
Y D+ T K + + + ++ESV ++ +++ E+N +++
Sbjct: 215 LIQYLDEIQTLTEANEKIEVQNQEMRKNLEESV--------QEMEKMTD-EYNRMKAIVH 265
Query: 493 QENIESELNSLRADYDNLVLDYEQ----LRTEKEEMELKLKEKNDLDEFEALERKTKKDQ 548
Q ++ ++ L+ + D+ L ++ L+++ EE + + N E L +K D+
Sbjct: 266 Q--TDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDE 323
Query: 549 EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM 608
++ + NL+ +K+A++ + D N ++ + + ++E++ QIK L E ++E
Sbjct: 324 IIEYQQMLHNLREKLKNAQL-DADKSNVMALQ-QGIQERDSQIKMLTE-----QVEQYTK 376
Query: 609 DLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEND 668
++ + IED K Q A T++ + ++S LKEK KE T + E D
Sbjct: 377 EMEKNTCIIEDLKNELQRNKGASTLSQQTHMK---IQSTLDILKEKTKEAERTAELAEAD 433
Query: 669 IQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKE 728
+ +L K D E + + + ++ + + +D + L +I L+ +
Sbjct: 434 AREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEI-LTKEINKLELK 492
Query: 729 LNKEVEENEALREEV-----------------------------ILLSELKSLPSEVERL 759
++ ++ENEALRE V ILL E++SL E L
Sbjct: 493 ISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDL 552
Query: 760 RKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL--------ATTQSN 811
+K+I+ ++E ++ ++ E+ QG + I + K DL A +++
Sbjct: 553 KKKIRQMAQERGKRSATSGLTTEDLNLTENISQG--DRISERKLDLLSLKNMSEAQSKNE 610
Query: 812 YKS-----TDQEFQNFKTLHMDFEQKYKMVLEENERMNQ---EIVNLSKEAQK------- 856
+ S +++ + +T+ F+ K K ++EEN+++ + EI+ KE QK
Sbjct: 611 FLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGG 670
Query: 857 ------------------------FDSSLGALKTELSYKTQELQEKTREVQERLNEMEQL 892
FD+SL LK ++ T +E +E++E E
Sbjct: 671 ETSLIIPSLERLVNAIESKNAEGIFDASL-HLKAQVDQLTGRNEELRQELRESRKEAINY 729
Query: 893 KEQLENRDSTLQTVEREKTLITEKLQQTL-------------EEVKTLTQEKDDLKQLQE 939
+QL + + +E+E +L+ + + + + + L L +
Sbjct: 730 SQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQ 789
Query: 940 SLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEE---VSRNLH 996
L+ + +LK N++ + N ++ +HQ+++ K +SE+ + +
Sbjct: 790 ELENKEKKLK---------NLEDSLEDYNRKFAVIRHQQSL-LYKEYLSEKETWKTESKT 839
Query: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSL-IQEKNEL 1055
++E + +D+ QQ + + + +L N + +D + E RKI L + EK+ +
Sbjct: 840 IKEEKRKLEDQVQQDAIKVKEYNNL--LNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
Query: 1056 QQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLG----------DELKKQQEIV---- 1101
+Q V E++ K + K+ E+ E +G ++ Q++V
Sbjct: 898 RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSV 957
Query: 1102 -AQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
E A K+ EL+ + + + L +++ L+ + + ++++E++ + K E+
Sbjct: 958 SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINK---EL 1014
Query: 1161 ENLKNELKNKELTLEHMETE-----RLELAQKLNENYEEVKSITK-----ERKVLKELQK 1210
E K +L E E ET+ ++ A+K N ++ SI+K E K L E Q+
Sbjct: 1015 EITKEKLHTIEQAWE-QETKLGNESSMDKAKKSITN-SDIVSISKKITMLEMKELNERQR 1072
Query: 1211 SFETER--DHLRGYIREIEATG--LQTK--EELKIAHIHLKEHQETIDELRRSVSEKTAQ 1264
+ ++ +HLR ++++E L+TK E KI K Q DEL SVS+ +
Sbjct: 1073 AEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSD 1132
Query: 1265 IINTQ--DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE-------LELLTEQS 1315
+ +LEK+ +L+ E+ L E ++ E+ Q+ + ++LL Q+
Sbjct: 1133 ADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQA 1192
Query: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375
+ + + +A++ + L + +++S+T + ++ LE K D+ ++ +
Sbjct: 1193 QSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYA 1252
Query: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
+ + Q++ + +++ E+F L +++++ K Q+ H
Sbjct: 1253 RLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHR 1312
Query: 1436 EMKSVAKEKD-DLQRLQEVLQSESDQLKENIKEIVAKHLETEE----ELKVAHCCLKEQE 1490
M++ E + L+ L+E++ + D + ++++ H++ EE ELK+ +K++E
Sbjct: 1313 NMENKTLEMELKLKGLEELISTLKD--TKGAQKVINWHMKIEELRLQELKLNRELVKDKE 1370
Query: 1491 ETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNEL 1550
E I L +SE E IS++++++ N K + Q +++ E +Q+ + NE+
Sbjct: 1371 E-IKYLNNIISEYERTISSLEEEIVQQN-KFHEERQMAWDQREVDLERQLDIFDRQQNEI 1428
Query: 1551 KQFKEHRKAKDSALQSIESKMLELTNRLQ----ESQEEIQIMIKEKEEMKRVQEALQIER 1606
+ + A SI L L N+L+ + +E I+I+++ + K ++E L+ +
Sbjct: 1429 LNAAQ---KFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKE 1485
Query: 1607 DQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEI---EHLKEQFETQKLNLENI 1663
L+ + I+++ K E L++ A E ++ + E+ E + T K+ + I
Sbjct: 1486 SALRLAEQNILSRDKVINELR---LRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTI 1542
Query: 1664 ETENIRLTQ----------ILHENLEEMRSVTKE-RDDLRSVEETLKVERDQLKENLRET 1712
RL Q +L + EE R + K+ +DL + L+++ D ++T
Sbjct: 1543 ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQT 1602
Query: 1713 ITRDLEKQEELKIV----HMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
DL KQ + + L E ++T+ + +S ++ + +DLE +
Sbjct: 1603 -AWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQRE---IT 1658
Query: 1769 DLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKAN 1828
+LK++E I + ++ + K++ V + L QK+ + ++LQ + +AN
Sbjct: 1659 ELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQ---AQKEAN 1715
Query: 1829 EHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVM 1888
T +++ E K S++ +KQ K S L +L E A+ E + S
Sbjct: 1716 SRAPTTTMRNLVERLK--SQLALKEKQQKALSRALLELRAEMTAAAE------ERIISAT 1767
Query: 1889 KERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKIS 1948
+++ V++ + +LK +++ L++++ LKT++ + ++ L ++
Sbjct: 1768 SQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQ 1827
Query: 1949 EKTIQISDI---QKDLDKSKDELQKKIQELQK---------------KELQLLRVKEDVN 1990
+K + I ++++D+ DEL+++I+ L +ELQ +VK+ N
Sbjct: 1828 KKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQ-RKVKKLEN 1886
Query: 1991 MSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERD-ELRRIKE 2049
K+ E++ K + +N + +R + KK +E IR KE++ E+ + +
Sbjct: 1887 QLEGKVEEVD--LKPMKEKNAKEELIRWEE---GKKWQAKIEGIRNKLKEKEGEVFTLTK 1941
Query: 2050 SLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLK-RYS 2108
L +D F K +K L+ L L+ + ++L R
Sbjct: 1942 QLNTLKDLF----------------AKADKEKLT-----LQRKLKTTGMTVDQVLGIRAL 1980
Query: 2109 EMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHR 2168
E + E L + +LDLE +I + ++A+ +LP + +E L N+ + H
Sbjct: 1981 ESEKELEELKKRNLDLENDI-------LYMRAHQALP--RDSVVEDLHLQNRYLQEKLHA 2031
Query: 2169 IMKKLK---YVLSYVTKIKEEQH-ESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSR 2224
+ K+ Y ++ I+ + H + + + + + + EL +++ +D
Sbjct: 2032 LEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKN 2091
Query: 2225 ELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEK 2284
++RDLK + +F + E ++ + V + + + + E T ++K
Sbjct: 2092 QVRDLK-----------EMCEFLKKEKAEVQRKLGHVRGSGRS-GKTIPELEKTIGLMKK 2139
Query: 2285 LKNGIQKENDRICQVNNFFNNRIIAIMNE-----STEFEERSATISKEWEQDLKSLKEKN 2339
+ +Q+EN+++ + + + +A + + E E+ A + + +S +
Sbjct: 2140 VVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGT 2199
Query: 2340 EKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMH 2399
EK+ + L+ L + KN + T ++ E L A+
Sbjct: 2200 EKIIAENERLRKELKKETDAAEKLRIAKNN--LEILNEKMTVQLEETGKRLQFAESRGPQ 2257
Query: 2400 KESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIE- 2458
E K K + VT + K+ E + K ++I L+ V KE E
Sbjct: 2258 LEGADSKSWKSIVVTR----MYETKLKELETDIAKKNQSITDLKQLV-------KEATER 2306
Query: 2459 DLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEH 2518
+ K+ DLE+ + E + T+ ++ + +V+RL L + ++A+ I +
Sbjct: 2307 EQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDK-EKAELIHQIEAN 2365
Query: 2519 TDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQN--EQLIKQKNELLSN 2576
D G + + L K + + + ++S L++Q+ E++ K K EL +
Sbjct: 2366 KDQ---------SGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENF 2416
Query: 2577 NQHLSNEVKTWKERTLKREAHKQVTCENSPK 2607
+ E++ K K E K + E K
Sbjct: 2417 DPSFFEEIEDLK-YNYKEEVKKNILLEEKVK 2446
Score = 253 bits (647), Expect = 1e-66
Identities = 499/2344 (21%), Positives = 972/2344 (41%), Gaps = 381/2344 (16%)
Query: 442 IPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELN 501
+P NI K +++ + + + ++ N L +LS++E N L E E+ ++
Sbjct: 1 MPPNINWK------EIMKVDPDDLPRQEELADNLLISLSKVEVNE----LKSEKQENVIH 50
Query: 502 SLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKN 561
R + ++ + +E+EL L+E E +A K + M+L +E+ +
Sbjct: 51 LFR-------ITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQ 103
Query: 562 LVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPK 621
+ + L NE+ + L +K+ +++ +++ ++ +K N ++ L
Sbjct: 104 SAGGRDT--RFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNE-------- 153
Query: 622 QMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKK 681
+A+ E++ LR EN LK+K ++L DI YQ Q++++K+
Sbjct: 154 --------------EAENENSKLRRENKRLKKKNEQLC-------QDIIDYQKQIDSQKE 192
Query: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQK--ELNKEVE-ENEA 738
+ E ++++K N EL + ++Q E N+++E +N+
Sbjct: 193 TLLSRRGEDSDYRSQLSKK--------------NYELIQYLDEIQTLTEANEKIEVQNQE 238
Query: 739 LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798
+R+ L+ E+E++ E +H + D+L E H + +VQ L + +
Sbjct: 239 MRKN------LEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL 292
Query: 799 GKT--KDDLATTQSNYK---------STDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847
+DD N K S D E ++ + + +K K + ++ N +
Sbjct: 293 KSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSN--V 350
Query: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907
+ L + Q+ DS + L ++ T+E+++ T +++ NE+++ K T ++
Sbjct: 351 MALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQ 410
Query: 908 REKTLITEKLQQ---TLEEVKTLTQEKDDLKQLQESLQIERDQLKS--DIHDTVNMNIDT 962
++ EK ++ T E + +EKD K+L E+L+ +D + D V +
Sbjct: 411 STLDILKEKTKEAERTAELAEADAREKD--KELVEALKRLKDYESGVYGLEDAVVEIKNC 468
Query: 963 QEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLE 1022
+ Q++ ++ + IN L+ KIS+ + N + E G LE
Sbjct: 469 KNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVG------------------LE 510
Query: 1023 AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIE 1082
K LT + ++++ ++QQ Q E+ I KE IE
Sbjct: 511 PKTMIDLT-EFRNSKHLKQQ-------------QYRAENQILLKE-------------IE 543
Query: 1083 NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQ 1142
+ EE RL +LKK+ +AQE+ G + + + + ++ E++
Sbjct: 544 SLEEERL---DLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQ-----GDRISERKLD 595
Query: 1143 LLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKER 1202
LL+++ MSE Q K NE L EL KE LE T + KL E EE K + +
Sbjct: 596 LLSLKN-MSEAQSK-NEF--LSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGM 651
Query: 1203 K----VLKELQKSFETERDHLRGYIREIE----ATGLQTKEELKIAHIHLKEHQETI--- 1251
K +KE+QK + + I +E A + E + A +HLK + +
Sbjct: 652 KEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGR 711
Query: 1252 -DELRRSVSEKTAQIIN-TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELE 1309
+ELR+ + E + IN +Q L K++ K+ L +E LL ++ + ++
Sbjct: 712 NEELRQELRESRKEAINYSQQLAKANLKIDH----LEKETSLL---RQSEGSNVVFKGID 764
Query: 1310 LLTEQSTTKDSTTLARIEMERL-RLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQL 1368
L S ++ + E L L ++ + ++++K+L D+L+ V Q
Sbjct: 765 L--PDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNL---EDSLEDYNRKFAVIRHQQ 819
Query: 1369 KEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSK 1428
+E L+ E ++ + +S +KE E K+ +++Q D+ ++ E L
Sbjct: 820 SLLYKEYLS---EKETWKTESKTIKE---EKRKLEDQVQQ----DAIKVK---EYNNLLN 866
Query: 1429 RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE 1488
LQ DEMK + E R VLQ L +V E E +L+ KE
Sbjct: 867 ALQMDSDEMKKILAENS---RKITVLQVNEKSLIRQYTTLV----ELERQLR------KE 913
Query: 1489 QEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEK-----EEQFNIKQISEV 1543
E+ NEL +E +I +Q+ E K+ +Q++ + E + KQ +E+
Sbjct: 914 NEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIA-ALQKVVDNSVSLSELELANKQYNEL 972
Query: 1544 QEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQ 1603
K ++ Q + S L+ +E + + L +++ +E++I KE++ +++A +
Sbjct: 973 TAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEIT---KEKLHTIEQAWE 1029
Query: 1604 IERDQLKENTKEIVAKMKESQE-----KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKL 1658
E E++ + K + + K+ L+M +NE Q EH ++ +E +
Sbjct: 1030 QETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRA----EHCQKMYEHLRT 1085
Query: 1659 NLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLE 1718
+L+ +E N L E +TK D + VE+ L RD+L +++ + ++ D +
Sbjct: 1086 SLKQMEERNFELETKFAE-------LTKINLDAQKVEQML---RDELADSVSKAVS-DAD 1134
Query: 1719 KQE--ELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ--- 1773
+Q EL+ M LK + ++ I + ++ Q+ + ++L+ Q L Q
Sbjct: 1135 RQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQS 1194
Query: 1774 -EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQL 1832
E+ IA +H + ++ K + +++ + +E N +L++K+ E E L
Sbjct: 1195 DEKSLIAKLH--QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDE---KEQAL 1249
Query: 1833 ITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENL---EEMKSVMK 1889
+ + K + + Q ++ +L L++ E + + Q ++ L +EMK+ +
Sbjct: 1250 YYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQ 1309
Query: 1890 ERDNL--RRVEETLKLER-DQLKESLQETKARDLEIQ----------QELKTARMLSKEH 1936
E N+ + +E LKL+ ++L +L++TK I QELK R L K+
Sbjct: 1310 EHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKD- 1368
Query: 1937 KETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKI 1996
KE + L ISE IS +++++ + +++ ++E+ L R +++ ++
Sbjct: 1369 KEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLER---QLDIFDRQQ 1425
Query: 1997 NEMEQLKKQFEAQNLSMQ--SVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKME 2054
NE+ ++FE S+ S+ + N QL L + E IRI+ + R + ++E LK +
Sbjct: 1426 NEILNAAQKFEEATGSIPDPSLPLPN-QLEIALRKIKENIRIILETRATCKSLEEKLKEK 1484
Query: 2055 RDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHY 2114
+ +++RD+ ++++ ++ ++ + E R++ E ++ H
Sbjct: 1485 ESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEM----EPKSHHTLKIAHQ 1540
Query: 2115 ECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLK 2174
N + +KE +K + KA + KH E L + R ++ + K K
Sbjct: 1541 TIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFK 1600
Query: 2175 YVL-----SYVTKIKEEQHE-SINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRD 2228
T + +H + + E ++ + LL+K++ + QD + RE+ +
Sbjct: 1601 QTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLE-RQREITE 1659
Query: 2229 LKLNQNMDLHIEEILKDFSESEFPSIKTEFQQV---LSNRKEMTQFLEEWL------NTR 2279
LK+ + ++ ++ L++ E E +K E + + L ++ +Q L+ L N+R
Sbjct: 1660 LKVKEFENIKLQ--LQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSR 1717
Query: 2280 FDIEKLKNGIQKENDRIC---QVNNFFNNRIIAIMNESTEFEER---SATISKEWEQDLK 2333
++N +++ ++ + + ++ + E T E SAT KE +++
Sbjct: 1718 APTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQ 1777
Query: 2334 SLKEK------------NEKLFKNYQTLKTS----------------------------- 2352
+ ++ NE L K + LKTS
Sbjct: 1778 QIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKIL 1837
Query: 2353 -------------------LASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEA 2393
L SG Q P T DNK + K+++LEN L
Sbjct: 1838 REKEEIDQENDELKRQIKRLTSGLQGKPLT-DNKQSLIEE-----LQRKVKKLENQLEGK 1891
Query: 2394 KESAMHKESKIIKMQKELEVTNDIIAKLQAKVHE-SNKCLEKTKETIQV---LQDKVALG 2449
E K K ++EL + + K QAK+ NK EK E + L L
Sbjct: 1892 VEEVDLKPMKEKNAKEEL-IRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLF 1950
Query: 2450 AKPYKEEI---EDLKMKLVKIDLEKMKNAKEFEKEISATKA-TVEYQKEVIRL-LRENLR 2504
AK KE++ LK + +D A E EKE+ K ++ + +++ + + L
Sbjct: 1951 AKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALP 2010
Query: 2505 RSQQAQDTSVISEHT-------DPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEIS 2557
R +D + + + + Q S + SGI + L+KE
Sbjct: 2011 RDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHC----QREQELQKENL 2066
Query: 2558 KLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASK 2617
KL +N +L Q + + L N+V+ KE E K+ E K V G+
Sbjct: 2067 KLSSENIELKFQLEQANKDLPRLKNQVRDLKEMC---EFLKKEKAEVQRKLGHVRGSGRS 2123
Query: 2618 KKQI 2621
K I
Sbjct: 2124 GKTI 2127
Score = 245 bits (625), Expect = 5e-64
Identities = 441/2144 (20%), Positives = 926/2144 (43%), Gaps = 322/2144 (15%)
Query: 727 KELNKEVEENEALREEVILLSELKSLPS-EVERLRKEIQDKSEELHIIT-------SEKD 778
KE+ K V+ ++ R+E + + L SL EV L+ E Q+ L IT +++
Sbjct: 8 KEIMK-VDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEV 66
Query: 779 KLFSEVVHKESRVQGLLEEIGKTK-----DDLATTQSNYKSTDQEF--QNFKTLHMDFEQ 831
+L E V K Q E KTK ++L Q + D F L EQ
Sbjct: 67 ELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQ 126
Query: 832 KYKMV------LEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQER 885
K + + LE+ +++N+++ ++EA+ +S L L K ++L + + Q++
Sbjct: 127 KDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQ 186
Query: 886 LNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL--------KQL 937
++ ++ DS ++ +K +L Q L+E++TLT+ + + K L
Sbjct: 187 IDSQKETLLSRRGEDSDYRSQLSKKNY---ELIQYLDEIQTLTEANEKIEVQNQEMRKNL 243
Query: 938 QESLQI------ERDQLKSDIHDTVNMNIDTQEQLRNALESLK-QHQETINTLKSKISEE 990
+ES+Q E +++K+ +H T N+ +QL+ + + Q QE + LKSK E+
Sbjct: 244 EESVQEMEKMTDEYNRMKAIVHQTDNVI----DQLKKENDHYQLQVQELTDLLKSKNEED 299
Query: 991 ----VSRNLHMEE------NTGETKDEFQQKMVGIDKKQ-----DLEAKNTQTLTADVKD 1035
V+ N +EE + + E+QQ + + +K D + N L ++
Sbjct: 300 DPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQ- 358
Query: 1036 NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKEN-------IEMTIENQEELR 1088
E+ +I L ++ + + +E E LK +L+ N + ++ Q L
Sbjct: 359 ----ERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLD 414
Query: 1089 LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE---KLKEKSQQLQEKQQQLLN 1145
+L ++ K+ + + A +K+ EL RL + E L++ +++ + Q+
Sbjct: 415 ILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKI 474
Query: 1146 VQEEMSEMQKKINEIE-NLKNELKNKELTLEHMETE---RLELAQKLNENYEEVKSITKE 1201
E+ + K+IN++E + + L E E + E ++L + N + + + E
Sbjct: 475 RDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAE 534
Query: 1202 RKVLKELQKSFETERDHLRGYIREI--------EATGLQTKE--------------ELKI 1239
++L + +S E ER L+ IR++ +GL T++ E K+
Sbjct: 535 NQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKL 594
Query: 1240 AHIHLK---EHQETIDELRRSVSEKTAQIINTQDLEKSHT---KLQEEIPVLHEE-QELL 1292
+ LK E Q + L R + EK +DLE+S T K Q ++ L EE ++L
Sbjct: 595 DLLSLKNMSEAQSKNEFLSRELIEK------ERDLERSRTVIAKFQNKLKELVEENKQLE 648
Query: 1293 PNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERD 1352
+KE+ + + M + + T+L +ERL +N ++ E I +
Sbjct: 649 EGMKEILQAIKEMQK-----DPDVKGGETSLIIPSLERL-VNAIESKNAEGIFDASL--- 699
Query: 1353 NLKTIKEALEVKHDQLKEHIRET----------LAKIQ---ESQSKQEQSLNMKEKDNET 1399
+LK + L ++++L++ +RE+ LAK + K+ L E N
Sbjct: 700 HLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVV 759
Query: 1400 TKIVSEMEQFKPKDSALLRIEIE-MLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQ--- 1455
K + + P ++++ + E ++ L + L+ ++K++ +D R V++
Sbjct: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
Query: 1456 --------SESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507
SE + K K I + + E++++ +KE +N L+++ E + +
Sbjct: 820 SLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKIL 879
Query: 1508 STIQKQLEA--INDK-----------LQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK 1554
+ +++ +N+K L+ ++++ EK++ + +EV EK+ L++FK
Sbjct: 880 AENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFK 939
Query: 1555 EHRKAKDSALQ-----SIESKMLELTNR------------LQESQEEIQIM--------- 1588
E K +ALQ S+ LEL N+ LQ+ +Q
Sbjct: 940 EMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECE 999
Query: 1589 -IKEKEEMKRVQEALQIERDQL-----------KENTKEIVAKMKE--------SQEKEY 1628
I KE+++ + + L+I +++L K + + K K+ S K+
Sbjct: 1000 NISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKI 1059
Query: 1629 QFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKER 1688
L+M +NE Q EH ++ +E + +L+ +E N L + +TK
Sbjct: 1060 TMLEMKELNERQ----RAEHCQKMYEHLRTSLKQMEERNFELE-------TKFAELTKIN 1108
Query: 1689 DDLRSVEETLKVERDQLKENLRETIT-RDLEKQEELKIVHMHLKEHQETIDKLRGIVSEK 1747
D + VE+ L RD+L +++ + ++ D ++ EL+ M LK + ++ I +
Sbjct: 1109 LDAQKVEQML---RDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQ 1165
Query: 1748 TNEISNMQKDLEHSNDALKAQDLKIQ----EELRIAHMHLKEQQETIDKLRGIVSEKTDK 1803
++ Q+ + ++L+ Q L Q E+ IA +H + ++ K +
Sbjct: 1166 VEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLH--QHNVSLQLSEATALGKLES 1223
Query: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTL 1863
+++ + +E N +L++K+ E E L + + K + + Q ++ +L L
Sbjct: 1224 ITSKLQKMEAYNLRLEQKLDE---KEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPL 1280
Query: 1864 SKLEIENLNLAQKLHENL---EEMKSVMKERDNL--RRVEETLKLE-RDQLKESLQETKA 1917
++ E + + Q ++ L +EMK+ +E N+ + +E LKL+ ++L +L++TK
Sbjct: 1281 AQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKG 1340
Query: 1918 RDLEIQ----------QELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE 1967
I QELK R L K+ KE + L ISE IS +++++ +
Sbjct: 1341 AQKVINWHMKIEELRLQELKLNRELVKD-KEEIKYLNNIISEYERTISSLEEEIVQQNKF 1399
Query: 1968 LQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSM--QSVRMDNFQLTK 2025
+++ ++E+ L R +++ ++ NE+ ++FE S+ S+ + N QL
Sbjct: 1400 HEERQMAWDQREVDLER---QLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPN-QLEI 1455
Query: 2026 KLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDG 2085
L + E IRI+ + R + ++E LK + + +++RD+ ++++ ++
Sbjct: 1456 ALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAER 1515
Query: 2086 QQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLP 2145
++ + E R++ E ++ H N + +KE +K + KA
Sbjct: 1516 EKLIAELGRKE----MEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQR 1571
Query: 2146 YLQTKHIEKLFTANQRCSMEFHRIMKKLK-----YVLSYVTKIKEEQH-ESINKFEMDFI 2199
+ KH E L + R ++ + K K + T + +H + + E
Sbjct: 1572 EIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVA 1631
Query: 2200 DEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQ 2259
++ + LL+K++ + QD + RE+ +LK+ + ++ ++ L++ E E +K E +
Sbjct: 1632 EQDDSLSSLLVKLKKVSQDLE-RQREITELKVKEFENIKLQ--LQENHEDEVKKVKAEVE 1688
Query: 2260 Q---VLSNRKEMTQFLEEWL------NTRFDIEKLKNGIQKENDRIC---QVNNFFNNRI 2307
+L ++ +Q L+ L N+R ++N +++ ++ + + +
Sbjct: 1689 DLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRAL 1748
Query: 2308 IAIMNESTEFEER---SATISKEWEQDLKSLKEKNEKLFK-NYQTLKTSLASGAQVNPTT 2363
+ + E T E SAT KE +++ + +++ + K + L +L + T+
Sbjct: 1749 LELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTS 1808
Query: 2364 QDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTND------- 2416
++ +N T+ + +L N L + +++ +KI++ ++E++ ND
Sbjct: 1809 KNRENS---------LTDNLNDLNNELQKKQKA----YNKILREKEEIDQENDELKRQIK 1855
Query: 2417 -IIAKLQAKVHESNK--CLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMK 2473
+ + LQ K NK +E+ + ++ L+++ L K + +++ +K K K +L + +
Sbjct: 1856 RLTSGLQGKPLTDNKQSLIEELQRKVKKLENQ--LEGKVEEVDLKPMKEKNAKEELIRWE 1913
Query: 2474 NAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGG 2533
K+++ +I + ++ ++ + L + L +D ++ K T G
Sbjct: 1914 EGKKWQAKIEGIRNKLKEKEGEVFTLTKQL---NTLKDLFAKADKEKLTLQRKLKTTGMT 1970
Query: 2534 SGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQ-----HLSNEVKTWK 2588
V +AL + E L+K L +N+ L + ++ L + HL N K
Sbjct: 1971 VDQVLGIRALESEKELEELKKR--NLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEK 2028
Query: 2589 ERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQ 2632
L+++ K ++ P ++G S + ++ NL+
Sbjct: 2029 LHALEKQFSK-----DTYSKPSISGIESDDHCQREQELQKENLK 2067
Score = 222 bits (565), Expect = 4e-57
Identities = 471/2264 (20%), Positives = 951/2264 (42%), Gaps = 369/2264 (16%)
Query: 100 EDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVN 159
+D + V A + ++ I D E + + E + + K + +++ +
Sbjct: 299 DDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQ 358
Query: 160 -RNVYVADLTEEVV-YTSEMALKWIT----KGEKSRHYGETKMNQRSSRSHTIFRMILES 213
R+ + LTE+V YT EM K E R+ G + ++Q++ IL+
Sbjct: 359 ERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKE 418
Query: 214 REKGEPSNCE---GSVKVSHLNLVDLAGSERAAQTGAAG-----VRLKEGCNI----NRS 261
+ K E + LV+ + ++G G V +K N +R
Sbjct: 419 KTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDRE 478
Query: 262 LFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQ 321
+ IL + I KL + ++ F++ ++ L+ +G KT I T +
Sbjct: 479 IEILTKEINKL-ELKISDFLDENEA-----LRERVGLEPKTMIDLT-------------E 519
Query: 322 FASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLE------TRAQAMEKDQ 375
F ++ K++K Y E ++ +E +DLKK++ +++ E T E
Sbjct: 520 FRNS-KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLN 578
Query: 376 LAQLLEEKDLL--QKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKI-NKMK 432
L + + + D + +K+ ++N++ + L+ + K + R + K NK+K
Sbjct: 579 LTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLK 638
Query: 433 NSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLN 492
+ N K +I +++ + E+ + +L+ L A + N
Sbjct: 639 E---LVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVN-----AIESKN 690
Query: 493 QENIESELNSLRADYDNLVLDYEQLRTEKEEMELK--------LKEKNDLDEFEALERKT 544
E I L+A D L E+LR E E + K +D E
Sbjct: 691 AEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLL 750
Query: 545 KKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLE 604
++ + ++ + +L + + + + +NE + LL+E E++ KKL+ DS +
Sbjct: 751 RQSEGSNVVFKGIDLPDGIAPSSASIINSQNEY--LIHLLQELENKEKKLKNLEDSLEDY 808
Query: 605 NIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQ 664
N K + +S+ K+ L + ET K ES ++ E +L++++++ A K+
Sbjct: 809 NRKFAVIRHQQSL----LYKEYLSEKET----WKTESKTIKEEKRKLEDQVQQDAIKVKE 860
Query: 665 MENDIQLYQSQLEAKKKMQVDLEKEL-------QSAFNEITKLTSL-----IDGKVPKDL 712
N + Q + KK+ + +++ +S + T L L + + K+
Sbjct: 861 YNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNE 920
Query: 713 LCNLELE--GKITDLQKELNKEVEENEALREEV---ILLSELKSLPSEVERLR---KEIQ 764
L ++E E KI LQ+ + + AL++ V + LSEL+ + L ++I
Sbjct: 921 LLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDIL 980
Query: 765 DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT 824
K L TS + L E + + +V+ + +E+ TK+ L T + ++ +QE +
Sbjct: 981 QKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIE---QAWEQETKLGNE 1037
Query: 825 LHMDFEQK-----------YKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQ 873
MD +K K+ + E + +N+ ++ QK L ++ +
Sbjct: 1038 SSMDKAKKSITNSDIVSISKKITMLEMKELNER--QRAEHCQKMYEHLRTSLKQMEERNF 1095
Query: 874 ELQEKTREVQERLNEMEQLKEQL--ENRDSTLQTV---EREKTLITEKLQQTLE-EVKTL 927
EL+ K E+ + + +++++ L E DS + V +R++ L EK + L+ EV L
Sbjct: 1096 ELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKL 1155
Query: 928 TQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQL--RNALESLKQHQET------ 979
+ D ++ E L ++ ++ +D Q Q ++ + L QH +
Sbjct: 1156 REISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEA 1215
Query: 980 -----INTLKSKISEEVSRNLHMEENTGETKDE-FQQKMVGIDKKQDLEAKNTQTLTADV 1033
+ ++ SK+ + + NL +E+ E + + ++ G ++ + L + Q+L
Sbjct: 1216 TALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR-QTIQSLRRQF 1274
Query: 1034 KDNEIIEQQRKIF-SLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQ-------- 1084
+ QQ K ++IQ +N+ ++++ + +++ + + +EM ++ +
Sbjct: 1275 SGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELIST 1334
Query: 1085 -----------------EELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDR-LAEVE 1126
EELRL ELK +E+V ++ IK + +R ++ +E
Sbjct: 1335 LKDTKGAQKVINWHMKIEELRL--QELKLNRELVKDKEE--IKYLNNIISEYERTISSLE 1390
Query: 1127 EKLKEKSQQLQEKQ----QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHME---T 1179
E++ ++++ +E+Q Q+ ++++ ++ ++ NEI N + + ++
Sbjct: 1391 EEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLP 1450
Query: 1180 ERLELA-QKLNENYEEVKSITKERKVLKELQKSFETERDHLR----------GYIREIEA 1228
+LE+A +K+ EN ++ I + R K L++ + + LR I E+
Sbjct: 1451 NQLEIALRKIKEN---IRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRL 1507
Query: 1229 TGLQTKEELKI------------AHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT 1276
T E K+ +H LK +TI ++ +++K + Q L +
Sbjct: 1508 RLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAR 1567
Query: 1277 KLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEK 1336
+ Q EI HEE + + + + ++N+ + T K S T +RL E
Sbjct: 1568 EEQREIVKKHEEDLHILHHRLELQADSSLNKFK-QTAWDLMKQSPTPVPTNKHFIRLAEM 1626
Query: 1337 FQESQEEIKSLTKERDNLKTIKEALEVKHD--------------QLKEHIRETLAKIQES 1382
Q E+ SL+ LK + + LE + + QL+E+ + + K++
Sbjct: 1627 EQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAE 1686
Query: 1383 QSKQEQSLNMKEKDNETTKIVSEMEQFKPKDS----ALLRIEIEML------------GL 1426
+ L+ +K+++ K SE++ K +S +R +E L L
Sbjct: 1687 VEDLKYLLDQSQKESQCLK--SELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKAL 1744
Query: 1427 SKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL 1486
S+ L E EM + A+E+ + + + N+++IV +H T E L
Sbjct: 1745 SRALLELRAEMTAAAEER-------IISATSQKEAHLNVQQIVDRH--TRE--------L 1787
Query: 1487 KEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFN--IKQISEVQ 1544
K Q E +NE NL + + + T + + ++ D L + E+ +K++ +N +++ E+
Sbjct: 1788 KTQVEDLNE---NLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEID 1844
Query: 1545 EKVNELK----------QFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM-IKEK- 1592
++ +ELK Q K K S ++ ++ K+ +L N+L+ EE+ + +KEK
Sbjct: 1845 QENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKN 1904
Query: 1593 --------EEMKRVQEALQIERDQLKENTKEIVAKMKE-----------SQEKEYQFLKM 1633
EE K+ Q ++ R++LKE E+ K+ +EK K+
Sbjct: 1905 AKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKL 1964
Query: 1634 TAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRS 1693
T +++ I L+ + E ++L N++ EN L H+ L V R
Sbjct: 1965 KTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRY 2024
Query: 1694 VEETL-----KVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGI--VSE 1746
++E L + +D + I D Q E ++ +LK E I+ + ++
Sbjct: 2025 LQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANK 2084
Query: 1747 KTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMH--------LKEQQETIDKLRGIV- 1797
+ N +DL+ + LK + ++Q +L H+ + E ++TI ++ +V
Sbjct: 2085 DLPRLKNQVRDLKEMCEFLKKEKAEVQRKL--GHVRGSGRSGKTIPELEKTIGLMKKVVE 2142
Query: 1798 -----SEKTDKLSNM-----QKDLENSNAKLQEKIQELKAN-EHQL-ITLKKDVNETQKK 1845
+E+ K S + ++E N KL+ ++++LKA+ HQL + + T+K
Sbjct: 2143 KVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKI 2202
Query: 1846 VSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER 1905
++E E+L+K++K ++ KL I NL E L E +V ++EET K R
Sbjct: 2203 IAENERLRKELKKETDAAEKLRIAKNNL-----EILNEKMTV--------QLEETGK--R 2247
Query: 1906 DQLKESL-QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDI------- 1957
Q ES + + D + + + RM + KE L I++K I+D+
Sbjct: 2248 LQFAESRGPQLEGADSKSWKSIVVTRMYETKLKE----LETDIAKKNQSITDLKQLVKEA 2303
Query: 1958 ---QKDLDKSKDELQKKIQELQ------------KKELQLLRVKEDVNMSHKKINEMEQL 2002
++ ++K ++L+++I+ L+ K+ELQ+LR+ +H+ E +L
Sbjct: 2304 TEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRL-----ANHQLDKEKAEL 2358
Query: 2003 KKQFEA--QNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIA 2060
Q EA +S D QL +K+ + ++++ E+ L+ + LK E + F
Sbjct: 2359 IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDP 2418
Query: 2061 TLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELL 2104
+ E I + N++ + +K +L L EK ++ E L
Sbjct: 2419 SFFEEIEDLKYNYKEEVKKNIL----------LEEKVKKLSEQL 2452
Score = 154 bits (390), Expect = 9e-37
Identities = 317/1539 (20%), Positives = 636/1539 (41%), Gaps = 278/1539 (18%)
Query: 325 TAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKD 384
TAKY N + + L+ E + LK+Q+E ++ E + + Q E++
Sbjct: 973 TAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQET 1032
Query: 385 LLQKVQNEKIENLTRMLVTSSSL-------TLQQELKAKRKRRVTWCLG-------KINK 430
K+ NE + + +T+S + T+ + + ++R C + +
Sbjct: 1033 ---KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQ 1089
Query: 431 MKNSNYA--DQFNIPTNITTKTHKLSINLLREIDESVCS------------------ESD 470
M+ N+ +F T I K+ L E+ +SV E
Sbjct: 1090 MEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELK 1149
Query: 471 VFSNTLDTLSEIEWNPATKLLN--QENIESELNSLRADYDNLVLDYEQLRTEKE------ 522
V + L +S+I ++LN Q++ + E+ SLR +LDY+ EK
Sbjct: 1150 VEVSKLREISDIA-RRQVEILNAQQQSRDKEVESLRMQ----LLDYQAQSDEKSLIAKLH 1204
Query: 523 --EMELKLKEKNDLDEFEALERKTKK-------------DQEMQLIHEISNLKNLVKHAE 567
+ L+L E L + E++ K +K ++E L + +N KH
Sbjct: 1205 QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR 1264
Query: 568 VYNQDLENELSSKVELLREKE----------DQIKKLQEYIDSQK----LENIKMDLSYS 613
Q L + S + L ++++ D++K +QE +SQ+ +EN +++
Sbjct: 1265 QTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELK 1324
Query: 614 LESIEDP-KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLY 672
L+ +E+ +K T + + K E LR + L+L ++ + K + N I Y
Sbjct: 1325 LKGLEELISTLKDTKGAQKVINWHMKIEE--LRLQELKLNRELVKDKEEIKYLNNIISEY 1382
Query: 673 Q---SQLEAKKKMQVDLEKELQSAFNE----ITKLTSLIDGKVPKDLLCNLELE---GKI 722
+ S LE + Q +E Q A+++ + + + D + + L + E G I
Sbjct: 1383 ERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSI 1442
Query: 723 TDLQKELNKEVE-ENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLF 781
D L ++E ++E + ++ E ++ +E KE + +DK+
Sbjct: 1443 PDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVI 1502
Query: 782 SEV---VHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQ---KYKM 835
+E+ + + + L+ E+G+ K+ + K Q N + E+ KY+
Sbjct: 1503 NELRLRLPATAEREKLIAELGR-KEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQR 1561
Query: 836 VLEENERMNQEIVNLSKE---------AQKFDSSLGALKT-------------------- 866
+LE+ +EIV +E + DSSL K
Sbjct: 1562 LLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFI 1621
Query: 867 ELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLE-EVK 925
L+ Q + E+ + L +++++ + LE + + +E I +LQ+ E EVK
Sbjct: 1622 RLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVK 1681
Query: 926 TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQ-LRNALESLKQHQETINTLK 984
+ E +DLK L + Q E LKS++ N +RN +E LK LK
Sbjct: 1682 KVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQL----ALK 1737
Query: 985 SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRK 1044
K + +SR L E + +M +++ + A T A + +I+++ +
Sbjct: 1738 EKQQKALSRALL----------ELRAEMTAAAEERIISA--TSQKEAHLNVQQIVDRHTR 1785
Query: 1045 IFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI---V 1101
+ K +++ + E+++ KE LKT +T + L L +EL+K+Q+ +
Sbjct: 1786 -----ELKTQVEDLNENLLKLKEALKTSKNRENSLT----DNLNDLNNELQKKQKAYNKI 1836
Query: 1102 AQEKNHAIKKEGELSRTCDRLAE--VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159
+EK ++ EL R RL + L + Q L E+ Q+ V++ ++++ K+ E
Sbjct: 1837 LREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQR--KVKKLENQLEGKVEE 1894
Query: 1160 IENLKNELKN-KELTLEHMETERLE-----LAQKLNENYEEVKSITKERKVLKELQKSFE 1213
++ + KN KE + E ++ + + KL E EV ++TK+ LK+L +
Sbjct: 1895 VDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKAD 1954
Query: 1214 TERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN------ 1267
E+ L+ R+++ TG+ + L I + E ++ ++EL++ + I+
Sbjct: 1955 KEKLTLQ---RKLKTTGMTVDQVLGIRAL---ESEKELEELKKRNLDLENDILYMRAHQA 2008
Query: 1268 ------TQDLEKSHTKLQEEIPVLHEEQEL----LPNVKEVSETQETMNELELLTEQSTT 1317
+DL + LQE++ L ++ P++ + E EL E
Sbjct: 2009 LPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKEN--- 2065
Query: 1318 KDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKE---HIR- 1373
++ E + L + +++ +++ L + +LK + E L+ + +++ H+R
Sbjct: 2066 ------LKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRG 2119
Query: 1374 -----ETLAKIQESQSKQEQSLNMKEKDNETTK-----IVSEMEQFKPKDSALLRIEIEM 1423
+T+ +++++ ++ + +++NE K + SE +++ L+ E+E
Sbjct: 2120 SGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEK 2179
Query: 1424 LGLSKRLQES-HDEMKSVAKEK--DDLQRLQEVLQSESD-----QLKENIKEIVAKHL-- 1473
L Q S H E K+ EK + +RL++ L+ E+D ++ +N EI+ + +
Sbjct: 2180 LKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTV 2239
Query: 1474 ---ETEEELKVAHC-----------------CLKEQEETINELRVNLSEKETEISTIQKQ 1513
ET + L+ A + E + EL ++++K I+ +++
Sbjct: 2240 QLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQL 2299
Query: 1514 LEAINDKLQ--NKIQEIYEKEEQFNIKQISEVQEKVNELKQ------FKEHRKAKDSAL- 1564
++ ++ Q NK E E++ + +K + E E LK+ H+ K+ A
Sbjct: 2300 VKEATEREQKVNKYNEDLEQQIKI-LKHVPEGAETEQGLKRELQVLRLANHQLDKEKAEL 2358
Query: 1565 ---------QSIESKMLELTNRLQESQEEIQIMIKE--------KEEMKRVQEALQI--- 1604
QS + ++L+E ++++ +K KEE+K++++ L+
Sbjct: 2359 IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDP 2418
Query: 1605 ----ERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET 1639
E + LK N KE V K +EK + + V T
Sbjct: 2419 SFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELT 2457
Score = 76.6 bits (187), Expect = 3e-13
Identities = 138/637 (21%), Positives = 271/637 (42%), Gaps = 97/637 (15%)
Query: 336 NEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEK-- 393
N+ S E L ++ +K L+ ++EEV L+ + K++L + E K K++ +
Sbjct: 1869 NKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNK 1928
Query: 394 -------IENLTRMLVT---------SSSLTLQQELKAKRKRRVTWCLG--------KIN 429
+ LT+ L T LTLQ++LK V LG ++
Sbjct: 1929 LKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMT-VDQVLGIRALESEKELE 1987
Query: 430 KMKNSNYADQFNI---------PTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS 480
++K N + +I P + + L L+E ++ + + + ++S
Sbjct: 1988 ELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSIS 2047
Query: 481 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL 540
IE + Q E + +L+ +N+ L ++ + K+ LK + DL E
Sbjct: 2048 GIESDDHC----QREQELQKENLKLSSENIELKFQLEQANKDLPRLK-NQVRDLKEMCEF 2102
Query: 541 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS 600
+K K + + +L H + ++ E+ + + VE ++ + +Q+KK + S
Sbjct: 2103 LKKEKAEVQRKLGHVRGSGRSGKTIPEL--EKTIGLMKKVVEKVQRENEQLKKASGILTS 2160
Query: 601 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAF-LRSENLELKEKMKELA 659
+K+ NI+ + +E ++K L ++ ++K + + +EN L++++K+
Sbjct: 2161 EKMANIEQENEKLKAELE---KLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKET 2217
Query: 660 TTYKQMENDIQLYQSQLEA-KKKMQVDLE---KELQSAFNEITKLTSLIDGKVPKDLLCN 715
+++ ++ ++ LE +KM V LE K LQ A + +L D K K ++
Sbjct: 2218 DAAEKL----RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGA-DSKSWKSIVVT 2272
Query: 716 LELEGKITDLQ-------------KELNKEVEE--------NEALREEVILLSELKSLPS 754
E K+ +L+ K+L KE E NE L +++ +L +
Sbjct: 2273 RMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAE 2332
Query: 755 EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS 814
+ L++E+Q L + + DK +E++H +I KD QS +S
Sbjct: 2333 TEQGLKRELQ----VLRLANHQLDKEKAELIH----------QIEANKD-----QSGAES 2373
Query: 815 TDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE 874
T + K D E + KM E + + +EI L KE + FD S +L Y +E
Sbjct: 2374 TIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKE 2433
Query: 875 LQEKTREVQERLNEM-EQLKEQLENRDSTLQTVEREK 910
+K ++E++ ++ EQL +L + + + E E+
Sbjct: 2434 EVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEE 2470
>gi|170784809 kinesin family member 17 isoform b [Homo sapiens]
Length = 1028
Score = 267 bits (683), Expect = 9e-71
Identities = 210/631 (33%), Positives = 318/631 (50%), Gaps = 48/631 (7%)
Query: 1 MAEEGAVAVCVRVRPLNSREESLG-------ETAQVYWKTDNNVIYQVDGSKSFNFDRVF 53
MA E AV V VR RP+N RE L + A+ N + K F FD +
Sbjct: 1 MASE-AVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAAD-EPPKQFTFDGAY 58
Query: 54 HGNETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSED---HLGVIPRAI 110
H + T+ +Y EIA P+++ +GYNGTIFAYGQT SGK++TM G D G+IPRA
Sbjct: 59 HVDHVTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAF 118
Query: 111 HDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEE 170
+F+ ++ + +FL+R SY+EIYNE + DLL K K L ++E + VYV L+
Sbjct: 119 EHVFESVQCAENTKFLVRASYLEIYNEDVRDLLGADTKQK-LELKEHPEKGVYVKGLSMH 177
Query: 171 VVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSH 230
V++ + G K+R G T MN+ SSRSH+IF + +E E + ++
Sbjct: 178 TVHSVAQCEHIMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERG--KDHLRAGK 235
Query: 231 LNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTR 290
LNLVDLAGSER ++TGA G RLKE IN SL LG VI L DG+ + YRDSKLTR
Sbjct: 236 LNLVDLAGSERQSKTGATGERLKEATKINLSLSALGNVISALVDGRC-KHVPYRDSKLTR 294
Query: 291 ILQNSLGGNAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRY 348
+LQ+SLGGN KT ++ ++P ++DETL+ L++A+ AK ++N P +NE D ALL+ Y
Sbjct: 295 LLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIRNKPRINEDPKD-ALLREY 353
Query: 349 RKEIMDLKKQLEEVSLETRAQAMEKDQLAQ---LLEEKDLLQKVQNEKIE---NLTRMLV 402
++EI LK L + + A+ Q+ +EEK L Q V +E L R
Sbjct: 354 QEEIKKLKAILTQQMSPSSLSALLSRQVPPDPVQVEEKLLPQPVIQHDVEAEKQLIREEY 413
Query: 403 TSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREID 462
L+ + KA+++ R I M+NS + N+ +T + +
Sbjct: 414 EERLARLKADYKAEQESRAR-LEEDITAMRNSYDVRLSTLEENLRKETEAV-------LQ 465
Query: 463 ESVCSESDVFSNTLDTLSEIEWNPA--TKLLNQENIESELNSLRAD------YDNLVLDY 514
V +++V S + S E+ PA + + + + S ++L +D + +
Sbjct: 466 VGVLYKAEVMSRA-EFASSAEYPPAFQYETVVKPKVFSTTDTLPSDDVSKTQVSSRFAEL 524
Query: 515 EQLRTEKEEMELKLKEKNDLDEFEALER----KTKKDQEMQLIHEISNLKNLVKHAEVYN 570
++ K E+ L E + L+E E + + E+ + E S + + E
Sbjct: 525 PKVEPSKSEISLGSSESSSLEETSVSEAFPGPEEPSNVEVSMPTEESRSRYFLD--ECLG 582
Query: 571 QDLENELSSKVELLREKEDQIKKLQEYIDSQ 601
Q+ L + L ++E Q LQ + Q
Sbjct: 583 QEAAGHLLGEQNYLPQEEPQEVPLQGLLGLQ 613
Score = 35.4 bits (80), Expect = 0.77
Identities = 54/272 (19%), Positives = 109/272 (40%), Gaps = 47/272 (17%)
Query: 1733 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDK 1792
+ ET+ LR + + I N + E DAL L+E QE I K
Sbjct: 319 YDETLSTLR--YANRAKNIRNKPRINEDPKDAL-----------------LREYQEEIKK 359
Query: 1793 LRGIVSEKTDKLS---NMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849
L+ I++++ S + + + +++EK+ +H + K+ + E ++ +
Sbjct: 360 LKAILTQQMSPSSLSALLSRQVPPDPVQVEEKLLPQPVIQHDVEAEKQLIREEYEE--RL 417
Query: 1850 EQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLK 1909
+LK K + + ++LE E++ M++ R L +EE L+ E + +
Sbjct: 418 ARLKADYKAEQESRARLE-----------EDITAMRNSYDVR--LSTLEENLRKETEAVL 464
Query: 1910 ESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQ 1969
+ KA + + +A ETV + K +D D SK ++
Sbjct: 465 QVGVLYKAEVMSRAEFASSAEYPPAFQYETV------VKPKVFSTTDTLPSDDVSKTQVS 518
Query: 1970 KKIQELQKKELQLLRVKEDVNMSHKKINEMEQ 2001
+ EL K E K ++++ + + +E+
Sbjct: 519 SRFAELPKVEPS----KSEISLGSSESSSLEE 546
>gi|170784807 kinesin family member 17 isoform a [Homo sapiens]
Length = 1029
Score = 267 bits (683), Expect = 9e-71
Identities = 210/631 (33%), Positives = 318/631 (50%), Gaps = 48/631 (7%)
Query: 1 MAEEGAVAVCVRVRPLNSREESLG-------ETAQVYWKTDNNVIYQVDGSKSFNFDRVF 53
MA E AV V VR RP+N RE L + A+ N + K F FD +
Sbjct: 1 MASE-AVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAAD-EPPKQFTFDGAY 58
Query: 54 HGNETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSED---HLGVIPRAI 110
H + T+ +Y EIA P+++ +GYNGTIFAYGQT SGK++TM G D G+IPRA
Sbjct: 59 HVDHVTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAF 118
Query: 111 HDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEE 170
+F+ ++ + +FL+R SY+EIYNE + DLL K K L ++E + VYV L+
Sbjct: 119 EHVFESVQCAENTKFLVRASYLEIYNEDVRDLLGADTKQK-LELKEHPEKGVYVKGLSMH 177
Query: 171 VVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSH 230
V++ + G K+R G T MN+ SSRSH+IF + +E E + ++
Sbjct: 178 TVHSVAQCEHIMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERG--KDHLRAGK 235
Query: 231 LNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTR 290
LNLVDLAGSER ++TGA G RLKE IN SL LG VI L DG+ + YRDSKLTR
Sbjct: 236 LNLVDLAGSERQSKTGATGERLKEATKINLSLSALGNVISALVDGRC-KHVPYRDSKLTR 294
Query: 291 ILQNSLGGNAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRY 348
+LQ+SLGGN KT ++ ++P ++DETL+ L++A+ AK ++N P +NE D ALL+ Y
Sbjct: 295 LLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIRNKPRINEDPKD-ALLREY 353
Query: 349 RKEIMDLKKQLEEVSLETRAQAMEKDQLAQ---LLEEKDLLQKVQNEKIE---NLTRMLV 402
++EI LK L + + A+ Q+ +EEK L Q V +E L R
Sbjct: 354 QEEIKKLKAILTQQMSPSSLSALLSRQVPPDPVQVEEKLLPQPVIQHDVEAEKQLIREEY 413
Query: 403 TSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREID 462
L+ + KA+++ R I M+NS + N+ +T + +
Sbjct: 414 EERLARLKADYKAEQESRAR-LEEDITAMRNSYDVRLSTLEENLRKETEAV-------LQ 465
Query: 463 ESVCSESDVFSNTLDTLSEIEWNPA--TKLLNQENIESELNSLRAD------YDNLVLDY 514
V +++V S + S E+ PA + + + + S ++L +D + +
Sbjct: 466 VGVLYKAEVMSRA-EFASSAEYPPAFQYETVVKPKVFSTTDTLPSDDVSKTQVSSRFAEL 524
Query: 515 EQLRTEKEEMELKLKEKNDLDEFEALER----KTKKDQEMQLIHEISNLKNLVKHAEVYN 570
++ K E+ L E + L+E E + + E+ + E S + + E
Sbjct: 525 PKVEPSKSEISLGSSESSSLEETSVSEAFPGPEEPSNVEVSMPTEESRSRYFLD--ECLG 582
Query: 571 QDLENELSSKVELLREKEDQIKKLQEYIDSQ 601
Q+ L + L ++E Q LQ + Q
Sbjct: 583 QEAAGHLLGEQNYLPQEEPQEVPLQGLLGLQ 613
Score = 35.4 bits (80), Expect = 0.77
Identities = 54/272 (19%), Positives = 109/272 (40%), Gaps = 47/272 (17%)
Query: 1733 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDK 1792
+ ET+ LR + + I N + E DAL L+E QE I K
Sbjct: 319 YDETLSTLR--YANRAKNIRNKPRINEDPKDAL-----------------LREYQEEIKK 359
Query: 1793 LRGIVSEKTDKLS---NMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849
L+ I++++ S + + + +++EK+ +H + K+ + E ++ +
Sbjct: 360 LKAILTQQMSPSSLSALLSRQVPPDPVQVEEKLLPQPVIQHDVEAEKQLIREEYEE--RL 417
Query: 1850 EQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLK 1909
+LK K + + ++LE E++ M++ R L +EE L+ E + +
Sbjct: 418 ARLKADYKAEQESRARLE-----------EDITAMRNSYDVR--LSTLEENLRKETEAVL 464
Query: 1910 ESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQ 1969
+ KA + + +A ETV + K +D D SK ++
Sbjct: 465 QVGVLYKAEVMSRAEFASSAEYPPAFQYETV------VKPKVFSTTDTLPSDDVSKTQVS 518
Query: 1970 KKIQELQKKELQLLRVKEDVNMSHKKINEMEQ 2001
+ EL K E K ++++ + + +E+
Sbjct: 519 SRFAELPKVEPS----KSEISLGSSESSSLEE 546
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 265 bits (677), Expect = 5e-70
Identities = 455/2268 (20%), Positives = 984/2268 (43%), Gaps = 332/2268 (14%)
Query: 517 LRTEKEEMELKLKEKNDLDEFEALERKTKKDQEM-QLIHEISNLKNLVKHAEVYNQDLEN 575
L + +E+E + E++ E ++ K++ D E +L ++ L L+ ++ N+D E
Sbjct: 249 LLAKTQELEKEAHERSQ----ELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEK 304
Query: 576 ELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVAL 635
+ + +++ E +++ E ++ + S S + E+ ++Q + D V +
Sbjct: 305 MIKA-----------LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMV 353
Query: 636 DAKRESA--FLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSA 693
+ A +LEL + Y+ + + L +S L +++ DL ++L
Sbjct: 354 EEGDNIAQGSGHENSLELDSSIFS-QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGC 412
Query: 694 FNEITKLTSLID-----GKVPKDLLCNL------------ELEGKITDLQKELNKEVEEN 736
+ L D GK + L L +L+G++ L KE +
Sbjct: 413 QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAR 472
Query: 737 EALREEVILLSE----LKSLPSEV----ERLRKEIQDKSEELHIITSEKDKLFSEVVHKE 788
E LR+++ +L + L+ + E+ + + + +++ EELH+ E+++L ++ E
Sbjct: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
Query: 789 SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIV 848
++ L E+ ++ L ++ + QE EQ + + E+
Sbjct: 533 AKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 849 NLSKEAQKFDSSLGAL---KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905
+L A K + AL K L+ + +L+E+ + V R+ EQ + L+ L
Sbjct: 593 DLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQ---VDLAE 649
Query: 906 VEREKTLITEK---LQQTLEEVKTLTQE-KDDLKQLQESLQIERDQLKSDIHDTVNMNID 961
E+ + + EK L+ L++ + E + DL+ +QE K +I ++ +
Sbjct: 650 AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE--------KEEIQKKLSESRH 701
Query: 962 TQEQLRNALESLKQHQETINTLKSKISEEV-SRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
QE LE L HQE +K EEV +R + +E K + ++ +++ +
Sbjct: 702 QQEAATTQLEQL--HQE------AKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQ 753
Query: 1021 LEAKNTQTLTA--DVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078
A+ Q L++ ++ ++ + E Q++ + K +L+ +++V KE +
Sbjct: 754 DLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI--------- 804
Query: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138
Q E+R L EL ++ QE++ A + +LA+ E++ K +Q +
Sbjct: 805 -----QGEVRCLKLELDTERSQAEQERDAAAR----------QLAQAEQEGKTALEQQKA 849
Query: 1139 KQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSI 1198
++ +N E E ++ ++ E K LE +E E++EL +L E E+++I
Sbjct: 850 AHEKEVNQLREKWEKERSWHQQELAK--------ALESLEREKMELEMRLKEQQTEMEAI 901
Query: 1199 TKERKVLKE------LQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252
+R+ + Q ETE++ + + T LQT++EL A L+ ++ +
Sbjct: 902 QAQREEERTQAESALCQMQLETEKERV-----SLLETLLQTQKELADASQQLERLRQDM- 955
Query: 1253 ELRRSVSEKTAQIINTQ------DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMN 1306
++++ ++T I+ TQ +L+++ + ++++ L EE L +++ + Q+ +
Sbjct: 956 KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSL--LQDKMDLQKQVE 1013
Query: 1307 ELELLTEQSTTKDSTTLARIEM-ERLRLNEKFQESQEEIK--------SLTKERDNLKTI 1357
+L+ ++ DS L E+ E+LR +++ Q+E++ SL ++ L +
Sbjct: 1014 DLK--SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVL 1071
Query: 1358 KEALEVKHDQLKEHIRETLAKIQESQ---SKQEQSLNMKEKDNETTKIVSEMEQFKPKD- 1413
+EA ++ +L +R+ + + Q Q S Q + L + K+ E + E + + +
Sbjct: 1072 QEADSIRQQELSA-LRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEA 1130
Query: 1414 ---------SALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKEN 1464
++L E + L RL+ + +++++A E+ + Q Q++ L
Sbjct: 1131 SHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ--AQAQLASLYSA 1188
Query: 1465 IKEIVAKHLETEEELK------VAHCCLKEQEETINEL-----RVNLSEKETEISTIQK- 1512
+++ + E+ EL + L+ + L + E S + K
Sbjct: 1189 LQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKL 1248
Query: 1513 -----QLEAINDKLQNKIQEIYEK--EEQFNIKQI-SEVQEKVNELKQFKEHRKAKDSAL 1564
+ + D L++++Q++ E+ + + Q+ +E+Q+ +L Q +E + +
Sbjct: 1249 HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQ 1308
Query: 1565 QSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624
S+ES+++EL + Q ++ ++ E + +E LQ ++ L + + A + E++
Sbjct: 1309 NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEAR 1368
Query: 1625 EKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV 1684
+ + E E L+ KL E +E+E R + + ++
Sbjct: 1369 AQ----ASAAGILE--------EDLRTARSALKLKNEEVESERERAQALQEQGELKVAQG 1416
Query: 1685 TKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE-----LKIVHMHLKEHQETIDK 1739
+++L + +TL ER++ E LR I ++LEKQ E L+++ + LK+ + +D
Sbjct: 1417 KALQENLALLTQTL-AEREEEVETLRGQI-QELEKQREMQKAALELLSLDLKKRNQEVD- 1473
Query: 1740 LRGIVSEKTNEISNMQKDLEHSNDALKAQDLKI---QEELRIAHMHLKEQQETIDKLRGI 1796
+ E+ E+ + LEH A++ ++ K+ +E++R +E Q + + + +
Sbjct: 1474 ---LQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD-RETQRNVLEHQLL 1529
Query: 1797 VSEKTDKLSNMQK----DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKK------- 1845
EK D++ Q+ DL+ L+ EL+ N H++ +K + E + +
Sbjct: 1530 ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVA 1589
Query: 1846 ----VSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEE-- 1899
++E+ ++++ QS + LE + LA++L E +E+KS ++ + L+R +E
Sbjct: 1590 LTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHL 1649
Query: 1900 TLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK 1959
T LER + LQ+ + + LE Q+ +T ++L ++ ++ LRE+ E T Q +Q+
Sbjct: 1650 TQDLERRDQELMLQKERIQVLEDQRTRQT-KILEEDLEQIKLSLRERGRELTTQRQLMQE 1708
Query: 1960 DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMD 2019
++ K + + L+ +L L +++V + I+E+++LK Q E Q +Q +
Sbjct: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQ---LQGLHRK 1765
Query: 2020 NFQLTKKLHESLEEIRIV------AKERDELRRIKESLKMERDQFIATL----REMIARD 2069
+ + L + +EI ++ A+E+ EL+ ++SL+ + D+ L +E+ A
Sbjct: 1766 VGETSLLLSQREQEIVVLQQQLQEAREQGELK--EQSLQSQLDEAQRALAQRDQELEALQ 1823
Query: 2070 RQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE-- 2127
++ Q + ++ + + L +L + +KE R+ E+ DH E RL +L E
Sbjct: 1824 QEQQQAQGQEERVKEKADALQGALEQAHMTLKE---RHGELQDHKEQARRLEEELAVEGR 1880
Query: 2128 ---------IEFQKELSMRVKANLSLPY----------LQTKHIEKLFTANQRCSMEFHR 2168
+ + E + KA L+L ++T+ ++ + Q E +
Sbjct: 1881 RVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQ 1940
Query: 2169 IMKKLKYVLSYVTKIKEE---------------QHESINKFEMDFIDEVEKQKELLIKIQ 2213
++ L+ S ++ +EE H ++ E +++ E + L
Sbjct: 1941 ELEALR-AESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA 1999
Query: 2214 HLQQD---CDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQ 2270
LQ C SR+L + Q ++ +++ + + + L +++E Q
Sbjct: 2000 TLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQ 2059
Query: 2271 FLEEWLNTRFD----IEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISK 2326
LE+ L R EK G ++E + I ++ + + + E E T
Sbjct: 2060 LLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRET--- 2116
Query: 2327 EWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQ-DNKNPHVTSRATQLT----TE 2381
+ +L++L ++ Q+LK + P Q + + R T+ E
Sbjct: 2117 QQRNNLEALPHSHKTSPMEEQSLKLD-----SLEPRLQRELERLQAALRQTEAREIEWRE 2171
Query: 2382 KIRELENSLHEAK--------------ESAMHKESKIIKMQKELEVTNDIIAK--LQAKV 2425
K ++L SL + K S + ++S+ ++Q ELE+T + K L +
Sbjct: 2172 KAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPG 2231
Query: 2426 HESNKCLEKTKETIQVLQDKVALGAKP---------YKEEIEDLKMKLVKIDLEKMKNAK 2476
S L E L + + A+P +++ +E L+ + ++++++ + +
Sbjct: 2232 ATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSR-LQ 2290
Query: 2477 EFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGI 2536
++ +T VE ++ +L RE +R +Q + IS+ T P+ + G G
Sbjct: 2291 RHNVQLRSTLEQVERERR--KLKREAMRAAQAG--SLEISKATASSPTQQD---GRGQ-- 2341
Query: 2537 VQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEV 2584
+N+ A + L+KE+ L+ Q KQK + ++ + S E+
Sbjct: 2342 -KNSDAKCV----AELQKEVVLLQAQLTLERKQKQDYITRSAQTSREL 2384
Score = 255 bits (651), Expect = 5e-67
Identities = 442/2068 (21%), Positives = 866/2068 (41%), Gaps = 339/2068 (16%)
Query: 335 VNEVSTDEALLKRYRKEIMDLKKQLEEVSLETR------------AQAMEKDQLAQL--- 379
V+ +S + LL++ R+E+ + LE+ + R AQ +++Q +L
Sbjct: 458 VDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLA 517
Query: 380 LEEKDLLQKV-------QNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMK 432
+ E++ LQ++ Q+E + L + S L+ EL + + VT L + +
Sbjct: 518 VRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSI 577
Query: 433 NSNYADQFNIPTNITT---------------KTHKLSINL----LREIDESVCSESDVFS 473
+ + + T + K+ +N L E ++SVCS +
Sbjct: 578 AELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAE 637
Query: 474 NTLDTL----SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLK 529
+ L +E E ++E++L L D ++ EKEE++ KL
Sbjct: 638 QARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLS 697
Query: 530 EKNDLDE-----FEALERKTKKDQEM---------QLIHEISNLKNLVKHAEVYNQDLEN 575
E E E L ++ K+ +E+ L+ E + L+ ++ E QDL
Sbjct: 698 ESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE 757
Query: 576 EL---SSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAET 632
+L SS ELL E + + Q+ + +E K L ++++ K++ Q
Sbjct: 758 QLQGLSSAKELL---ESSLFEAQQ--QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
Query: 633 VALDAKRESAFLRSENL--ELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690
+ LD +R A + +L + +E T +Q + + +QL K EKE
Sbjct: 813 LELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREK------WEKER 866
Query: 691 QSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNK---EVEENEALREEVILLS 747
E+ K ++ + +ELE ++ + Q E+ + EE E +
Sbjct: 867 SWHQQELAKALESLERE-------KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919
Query: 748 ELKSLPSEVERL------RKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKT 801
+L++ V L +KE+ D S++L E + ++ +VQ L E+
Sbjct: 920 QLETEKERVSLLETLLQTQKELADASQQL------------ERLRQDMKVQKLKEQ---- 963
Query: 802 KDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSL 861
+ Q+ + +E + H D + EE+ + Q+ ++L K+ + S L
Sbjct: 964 -ETTGILQTQLQEAQRELKEAARQHRD---DLAALQEESSSLLQDKMDLQKQVEDLKSQL 1019
Query: 862 GALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTL 921
A QE+QEK RE QE ++L+ E TL +E+E+ L+ + ++
Sbjct: 1020 VAQDDSQRLVEQEVQEKLRETQEYNRIQKELER--EKASLTLSLMEKEQRLLVLQEADSI 1077
Query: 922 --EEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979
+E+ L Q+ + + Q+ L + + L+ ++ + D Q LE L+ T
Sbjct: 1078 RQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE---KEADFLAQEAQLLEELEASHIT 1134
Query: 980 INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
L++ + + ++ ++ T+ + + L A+ +
Sbjct: 1135 EQQLRASLWAQEAKAAQLQLRLRSTESQL------------------EALAAEQQPGNQA 1176
Query: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLK--TDLKENIEMTIENQEELRLLGDE---- 1093
+ Q ++ SL + LQQ L SV + +L D ++ +Q R L
Sbjct: 1177 QAQAQLASLY---SALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLL 1233
Query: 1094 --LKKQQEIVAQEKNHAIKKEGELSRTC--DRLAEVEEKL----KEKSQ---QLQEKQQQ 1142
L + A K H + + +R D++ ++EE+L EKSQ +LQ+ Q+Q
Sbjct: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ 1293
Query: 1143 LLNVQEEMSEMQKKINEIE-----------NLKNELKNKELTLEHMETERLELAQKLNEN 1191
L QEE S+ + K N +E +L++ L+ EL + ER EL Q EN
Sbjct: 1294 LSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGER-ELLQAAKEN 1352
Query: 1192 ----YEEVKSITKERKVLKE----LQKSFETERDHLRGYIREIE-----ATGLQTKEELK 1238
E +++ E + L++ T R L+ E+E A LQ + ELK
Sbjct: 1353 LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412
Query: 1239 IAHIHLKEHQETIDELRRSVSEKTAQII----NTQDLEKSHTKLQEEIPVLHEEQELLPN 1294
+A K QE + L ++++E+ ++ Q+LEK + + +L +L
Sbjct: 1413 VA--QGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL--SLDLKKR 1468
Query: 1295 VKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354
+EV QE + ELE K + L + M +K +E+I+ L K+R+
Sbjct: 1469 NQEVDLQQEQIQELE--------KCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQ 1520
Query: 1355 KTIKE--ALEV-KHDQLKEHIR-------------ETLA-KIQESQSKQE-QSLNMKEKD 1396
+ + E LE+ K DQ+ E R E LA +++E+ K E Q +KE +
Sbjct: 1521 RNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELE 1580
Query: 1397 NE-----------TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKD 1445
+ T + ++ + + S + +E L++ LQE E+KS ++ +
Sbjct: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE 1640
Query: 1446 DLQRLQE-------------VLQSESDQ------------LKENIKEIVAKHLETEEELK 1480
+LQR +E +LQ E Q L+E++++I E EL
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELT 1700
Query: 1481 VAHCCLKEQEE-----------TINELRVNLSEKETEISTIQK---QLEAINDKLQNKIQ 1526
++E+ E ++ +++ L +KE E+ Q+ +L+ + D+L+ ++Q
Sbjct: 1701 TQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQ 1760
Query: 1527 EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586
++ K + ++ QE V +Q +E R+ + QS++S++ E L + +E++
Sbjct: 1761 GLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELE 1820
Query: 1587 IMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE- 1645
+ +E+++ + +E ++ + D L+ ++ +KE + E Q K A +E E
Sbjct: 1821 ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE-RHGELQDHKEQARRLEEELAVEG 1879
Query: 1646 --IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERD 1703
++ L+E + E + L Q E +E T+ D + + ERD
Sbjct: 1880 RRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERD 1939
Query: 1704 QLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN---EISNMQKDLEH 1760
Q E LR ++ QEE + QE + K + K E + + + LE
Sbjct: 1940 QELEALRAE-SQSSRHQEE--AARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEA 1996
Query: 1761 SN-------DALKAQDLKIQEELRIAHMHLKEQ----QETIDKLRGIVSEKTDKLSNMQK 1809
S DA +A +++E LRI +++Q QE + +L+ ++++ ++L + Q+
Sbjct: 1997 STATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 1810 DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIE 1869
+ L +++QE +I K+++ + +++ E+ L + +++ LTL++ E E
Sbjct: 2057 REQLLEKSLAQRVQE------NMIQEKQNLGQ-EREEEEIRGLHQSVRELQLTLAQKEQE 2109
Query: 1870 NLNLAQ-KLHENLEEM-----KSVMKERD-NLRRVEETLKLERDQLKESLQETKARDLEI 1922
L L + + NLE + S M+E+ L +E L+ E ++L+ +L++T+AR++E
Sbjct: 2110 ILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEW 2169
Query: 1923 QQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQL 1982
+++ + + + K +V L+E + + + + +DEL+ + L+K+ L
Sbjct: 2170 REKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHS 2229
Query: 1983 LRVKEDVNMSHK-----KINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIV 2037
+ + ++ E+ ++ + + QS R Q + L +++ + I
Sbjct: 2230 PGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWR----QRLEHLQQAVARLEI- 2284
Query: 2038 AKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKC 2097
+R L+R L+ +TL QV+ E+R L E++R
Sbjct: 2285 --DRSRLQRHNVQLR-------STL----------EQVERERRKLK------REAMRAAQ 2319
Query: 2098 SRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFT 2157
+ E+ K + + + + D + E QKE+ + ++A L+ L+ K + T
Sbjct: 2320 AGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVL-LQAQLT---LERKQKQDYIT 2375
Query: 2158 ANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185
+ + S E + L + L V + E
Sbjct: 2376 RSAQTSRELAGLHHSLSHSLLAVAQAPE 2403
Score = 229 bits (584), Expect = 3e-59
Identities = 415/2038 (20%), Positives = 867/2038 (42%), Gaps = 273/2038 (13%)
Query: 644 LRSENLELKEKMKE-LATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTS 702
L + L L+++M E A ++++++N + Q Q +K+Q + + +S E+ K
Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKV-LQYRSWCQELEKRLE 78
Query: 703 LIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKE 762
G +P+ N+E E + +L L +E + E+L E + ++L+ + + + K
Sbjct: 79 ATGGPIPQRWE-NVE-EPNLDELLVRLEEEQQRCESLAE---VNTQLRLHMEKADVVNKA 133
Query: 763 IQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNF 822
+++ E+L T + + E++ KES+ Q E K L S +E F
Sbjct: 134 LREDVEKL---TVDWSRARDELMRKESQWQMEQEFF---KGYLKGEHGRLLSLWREVVTF 187
Query: 823 KTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREV 882
+ + LE +++++ L E + SL L+ Q +
Sbjct: 188 R----------RHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNG--- 234
Query: 883 QERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942
+++ R+ + L+ K Q+ +E +QE L QL+
Sbjct: 235 ----------SGRMDGREPA------QLLLLLAKTQELEKEAHERSQE---LIQLKSQGD 275
Query: 943 IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTG 1002
+E+ +L+ + + + +Q+Q + + +K +ET+ L++ +E + + N
Sbjct: 276 LEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQ 335
Query: 1003 ETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLI--QEKNELQQMLE 1060
E K QQ + I + E N + +E IFS Q+ ++ ++
Sbjct: 336 EEKLSLQQVIKDITQVMVEEGDN---IAQGSGHENSLELDSSIFSQFDYQDADKALTLVR 392
Query: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKE-GELSRTC 1119
SV+ + Q DL++ + QE + LL +QQ +E+ A+++ +L+
Sbjct: 393 SVLTRRRQAVQDLRQQLAGC---QEAVNLL-----QQQHDQWEEEGKALRQRLQKLTGER 444
Query: 1120 DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179
D LA L+ + L ++++ L +EE+ + Q ++ E E + N EL L+
Sbjct: 445 DTLAGQTVDLQGEVDSLSKERELLQKAREELRQ-QLEVLEQEAWRLRRVNVELQLQGDSA 503
Query: 1180 ERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKI 1239
+ QK E EE+ +ER+ L+E+ E ++ E + + +E L+
Sbjct: 504 Q----GQK-EEQQEELHLAVRERERLQEMLMGLEAKQS-------ESLSELITLREALES 551
Query: 1240 AHIHLKEHQETIDELRRSVSEKTAQIINTQ----DLEKSHTKLQEEIPVLHEEQELLPNV 1295
+H+ + LR+ +E TA + + +L S L+ E+ L L +
Sbjct: 552 SHLE-------GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL 604
Query: 1296 KEVSETQET-MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354
E + +N+ L E+ + + E R L E+++ ++L ++ +L
Sbjct: 605 NEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHL 664
Query: 1355 KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDS 1414
+ + E +L+ +R+ + +E Q K +S + +E TT++ ++ K ++
Sbjct: 665 EAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA--ATTQLEQLHQEAKRQEE 722
Query: 1415 ALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHL- 1473
L R E L + +++V +++ DL + L S + L+ ++ E ++
Sbjct: 723 VLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSV 782
Query: 1474 --ETEEELKVAHCCLKEQEETI-NELRVNLSEKETEISTIQKQLEAINDKLQNKIQE--- 1527
T+ +L+V + + +E I E+R E +TE S +++ +A +L QE
Sbjct: 783 IEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKT 842
Query: 1528 IYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQI 1587
E+++ + K++++++EK + + + + AK AL+S+E + +EL RL+E Q E+
Sbjct: 843 ALEQQKAAHEKEVNQLREKWEKERSWHQQELAK--ALESLEREKMELEMRLKEQQTEM-- 898
Query: 1588 MIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMC--- 1644
EA+Q +R++ + + + +M+ EKE L T + +TQ+++
Sbjct: 899 ------------EAIQAQREEERTQAESALCQMQLETEKERVSLLETLL-QTQKELADAS 945
Query: 1645 -EIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEE---TLKV 1700
++E L++ + QKL + ET I TQ+ E + + RDDL +++E +L
Sbjct: 946 QQLERLRQDMKVQKLKEQ--ETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
Query: 1701 ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760
++ L++ + + ++ + + + ++V QE +KLR +T E + +QK+LE
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLV------EQEVQEKLR-----ETQEYNRIQKELER 1052
Query: 1761 SNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE 1820
+L ++ ++ L + +Q+ + LR + E + + +E +++E
Sbjct: 1053 EKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE 1112
Query: 1821 KIQELKANEHQLITLKKDVNETQKKV--------SEMEQLKKQIKDQSLTLSKLEIENL- 1871
K + A E QL+ + + T++++ ++ QL+ +++ L L E
Sbjct: 1113 KEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQP 1172
Query: 1872 -NLAQ------KLHENLEE-MKSVMKERDNLR----RVEETLKLERDQ------------ 1907
N AQ L+ L++ + SV + R L LE DQ
Sbjct: 1173 GNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPL 1232
Query: 1908 LKESLQETKARDL-EIQQELKTARMLSKEHKETVDKLREKI-------SEKTIQISDIQK 1959
L E A L ++ Q+L + ++ V KL E++ S+ ++ D+Q+
Sbjct: 1233 LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQR 1292
Query: 1960 DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMD 2019
L ++++E K + E +L+ + E + ++ E + + + + +Q+ + +
Sbjct: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKEN 1352
Query: 2020 NFQLTKKLHESLEEIRIVAKE----RDELRRIKESLKMERDQFIATLREMIARDRQNHQV 2075
+ L ++ E R A ++LR + +LK++ ++ + A Q
Sbjct: 1353 LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412
Query: 2076 KPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYE----CLNRLSLDLEK---EI 2128
+ + L + LT++L E+ ++ L + E++ E L LSLDL+K E+
Sbjct: 1413 VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472
Query: 2129 EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQH 2188
+ Q+E Q + +EK + + M +KL + ++++++
Sbjct: 1473 DLQQE--------------QIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRE 1518
Query: 2189 ESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSE 2248
N E + E+EK+ +++ + QD L L L + H
Sbjct: 1519 TQRNVLEHQLL-ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHH---------- 1567
Query: 2249 SEFPSIKTEFQQVLSNRKEMTQFLEEWLNTR--FDIEKLKNGIQKENDRICQVNNFFNNR 2306
K E QQ L E + + T D+E+ +Q ++ +I + + ++
Sbjct: 1568 ------KMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES--HST 1619
Query: 2307 IIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN 2366
++A E +ER +Q++KS +E+ E+L + + L TQD
Sbjct: 1620 VLA-----RELQER--------DQEVKSQREQIEELQRQKEHL-------------TQDL 1653
Query: 2367 KNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVH 2426
+ + L E+I+ LE+ +++KI ++++LE Q K+
Sbjct: 1654 ER---RDQELMLQKERIQVLEDQ--------RTRQTKI--LEEDLE---------QIKLS 1691
Query: 2427 ESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLK-MKLVKIDLEK-MKNAKEFEKEISA 2484
+ E T + Q++Q++ G P K + L+ MKL+ D EK ++ +E E+
Sbjct: 1692 LRERGRELTTQR-QLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750
Query: 2485 TKATVEYQKEVI--RLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGG-GSGIVQNTK 2541
K +E Q + + ++ +L SQ+ Q+ V+ + L S + + +
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQR 1810
Query: 2542 ALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQ 2599
AL + + + ++ + Q E+ +K+K + L L T KER + + HK+
Sbjct: 1811 ALAQRDQELEALQQEQQQAQGQEERVKEKADALQG--ALEQAHMTLKERHGELQDHKE 1866
>gi|13699824 kinesin family member 11 [Homo sapiens]
Length = 1056
Score = 257 bits (657), Expect = 1e-67
Identities = 260/937 (27%), Positives = 422/937 (45%), Gaps = 104/937 (11%)
Query: 7 VAVCVRVRPLNSREE-----SLGETAQVYWKTDNNVIYQVDGS--KSFNFDRVFHGNETT 59
+ V VR RP N E S+ E V + D S K++ FD VF +
Sbjct: 19 IQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQ 78
Query: 60 KNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMG----------SEDHL-GVIPR 108
+VY + PI+D I GYN TIFAYGQT +GKT+TM G ED L G+IPR
Sbjct: 79 IDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPR 138
Query: 109 AIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRN---VYVA 165
+H IF+K+ EF ++VS +EIYNE + DLL + + + D RN V +
Sbjct: 139 TLHQIFEKLTD-NGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIK 197
Query: 166 DLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGS 225
L E V+ + + + KG R T MN SSRSH++F + + +E + E
Sbjct: 198 GLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKE--TTIDGEEL 255
Query: 226 VKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRD 285
VK+ LNLVDLAGSE ++GA R +E NIN+SL LG+VI L + + YR+
Sbjct: 256 VKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERT--PHVPYRE 313
Query: 286 SKLTRILQNSLGGNAKTRIICTITPVS--FDETLTALQFASTAKYMKNTPYVNEVSTDEA 343
SKLTRILQ+SLGG +T II TI+P S +ETL+ L++A AK + N P VN+ T +A
Sbjct: 314 SKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKA 373
Query: 344 LLKRYRKEIMDLKKQL-------------EEVSLETRAQAMEKDQLAQLLEE----KDLL 386
L+K Y +EI LK+ L E + + ++++Q+ +L+E+ ++ L
Sbjct: 374 LIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEEL 433
Query: 387 QKVQNEKIENLTRMLVTSSSL-TLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTN 445
+V ++N + S L QEL+ +K K+ +K +
Sbjct: 434 NRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQE---TKLQLVKEEYITSALE---S 487
Query: 446 ITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRA 505
K H + LL ++E+ S + S LD ++ + A Q+ LNSL
Sbjct: 488 TEEKLHDAASKLLNTVEETTKDVSGLHSK-LDRKKAVDQHNAEA---QDIFGKNLNSLFN 543
Query: 506 DYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKH 565
+ + L+ D + E+ L AL+ T + +L ++ ++
Sbjct: 544 NMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTV--------ALGSLTSIPEN 595
Query: 566 AEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQ 625
+ + N + + L E + +++L + + L +++M LS ++ SI +
Sbjct: 596 VSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLK 655
Query: 626 TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQM-ENDI-QLYQSQLEAKKKMQ 683
+F D + + EL + L ++ EN I L +SQ + +
Sbjct: 656 HIFKTSLTVADK------IEDQKKELDGFLSILCNNLHELQENTICSLVESQKQC-GNLT 708
Query: 684 VDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV 743
DL+ Q+ E+ KL +L + LE K ++QK L+ V+EN + +
Sbjct: 709 EDLKTIKQTHSQELCKLMNLWTERF-------CALEEKCENIQKPLS-SVQENIQQKSKD 760
Query: 744 ILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKD 803
I + + ++ + S+EL E KL E V ++ G LE+I
Sbjct: 761 I----VNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKIS---- 812
Query: 804 DLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGA 863
+ T+Q ++ T + F +++ L E E QE+ NL + + + +
Sbjct: 813 ---------QETEQRCESLNTRTVYFSEQWVSSLNERE---QELHNLLEVVSQCCEASSS 860
Query: 864 LKTELSYKTQELQEKTREV---QERLNEMEQLKEQLE 897
TE S + EK + Q ++E + + + LE
Sbjct: 861 DITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLE 897
Score = 70.9 bits (172), Expect = 2e-11
Identities = 172/941 (18%), Positives = 369/941 (39%), Gaps = 122/941 (12%)
Query: 572 DLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA- 630
D E S KV LL +++ L N D+S L+ +DP+ + +
Sbjct: 149 DNGTEFSVKVSLLEIYNEELFDLL---------NPSSDVSERLQMFDDPRNKRGVIIKGL 199
Query: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMEND-----IQLYQSQLEAKKKMQVD 685
E + + K E + + + L Y + I + ++ ++ ++ +++
Sbjct: 200 EEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIG 259
Query: 686 LEKELQSAFNEITKLTSLID------GKVPKDLL-------CNLELEGKITDLQKELNKE 732
+ A +E + +D G + + LL +E + + +L +
Sbjct: 260 KLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRI 319
Query: 733 VEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQ 792
++++ R +++ + +E ++ +I+ + ++ + K++ ++
Sbjct: 320 LQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE---VNQKLTKKALIK 376
Query: 793 GLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSK 852
EEI + K DLA + E +NF+ + + + ++E E++ L++
Sbjct: 377 EYTEEIERLKRDLAAAREKNGVYISE-ENFRVMSGKLTVQEEQIVELIEKIGAVEEELNR 435
Query: 853 EAQKF---DSSLGALKTELSYKTQELQEKTREVQER----------LNEMEQLKEQLENR 899
+ F + L K++L KTQEL+ + +QE + +E +E+L +
Sbjct: 436 VTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDA 495
Query: 900 DSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQL----QESLQIERDQLKSDIHDT 955
S L E T L L+ K + Q + + + SL ++L D
Sbjct: 496 ASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSK 555
Query: 956 VNMNIDTQEQL-RNALESLKQHQETINTLK----SKISEEVSR------NLHMEENT--G 1002
++ + L N L S +TI T+ + I E VS N+ ++E +
Sbjct: 556 QKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAA 615
Query: 1003 ETKDEFQQ--KMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM-L 1059
E+K Q+ ++ D LE + T+ + +K N ++ K + +K E Q+ L
Sbjct: 616 ESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKEL 675
Query: 1060 ESVIAEKEQLKTDLKEN-IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRT 1118
+ ++ +L+EN I +E+Q++ L ++LK ++ +QE + E R
Sbjct: 676 DGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTE--RF 733
Query: 1119 C---DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE 1175
C ++ +++ L + +Q+K + ++N S QK + + EL+N
Sbjct: 734 CALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHS--QKFCADSDGFSQELRNFNQEGT 791
Query: 1176 HMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE 1235
+ E ++ + KLN N E++ T++R + + +E+ ++ + +
Sbjct: 792 KLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQ-----WVSSLNEREQELHN 846
Query: 1236 ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295
L++ + I E +S K A EK H +++ + +E +L+
Sbjct: 847 LLEVVSQCCEASSSDITE--KSDGRKAAH-------EKQHNIFLDQMTI--DEDKLIAQN 895
Query: 1296 KEVSETQET-MNELELLTEQSTTKD--------------STTLARIEMERLRLNEKFQES 1340
E++ET + + +L EQ D +TL R E L++ ++
Sbjct: 896 LELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQ 955
Query: 1341 QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSK------------QEQ 1388
E + L +N + ++V+ L ++ E L++ + Q +
Sbjct: 956 PELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHK 1015
Query: 1389 SLNMKEKDN------ETTKIVSEMEQFKPKDSALLRIEIEM 1423
+ K+K+N E +K+ E K LR +I +
Sbjct: 1016 KSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL 1056
Score = 68.2 bits (165), Expect = 1e-10
Identities = 194/975 (19%), Positives = 402/975 (41%), Gaps = 120/975 (12%)
Query: 866 TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK 925
TE S K L+ E+ + LN + E+L+ D R K + K LEE+
Sbjct: 152 TEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDP-----RNKRGVIIK---GLEEIT 203
Query: 926 TLTQEKDDLKQLQESLQIER-------DQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 978
KD++ Q+ E +R + S H ++ I +E + E +K +
Sbjct: 204 V--HNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGK- 260
Query: 979 TINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEI 1038
+N + SE + R+ +++ E + Q ++ + + +TA V+
Sbjct: 261 -LNLVDLAGSENIGRSGAVDKRAREAGN-INQSLLTLGR----------VITALVERTPH 308
Query: 1039 IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQ 1098
+ + + I + + + S+IA +L+E + T+E + + ++ + Q
Sbjct: 309 VPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLS-TLEYAHRAKNILNKPEVNQ 367
Query: 1099 EIVAQ-------EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMS 1151
++ + E+ +K++ +R + + EE + S +L +++Q++ + E++
Sbjct: 368 KLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIG 427
Query: 1152 EMQKKINEIENL----KNELKNKELTLEHMETERLELAQKLNENYEEVK-SITKERKVLK 1206
+++++N + L KNEL + L++ +T+ LE QK + +E K + KE +
Sbjct: 428 AVEEELNRVTELFMDNKNELDQCKSDLQN-KTQELETTQK---HLQETKLQLVKEEYITS 483
Query: 1207 ELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLK-EHQETIDELRRSVSEKTAQI 1265
L+ + E D + +E T TK+ ++ +H K + ++ +D+ AQ
Sbjct: 484 ALESTEEKLHDAASKLLNTVEET---TKD---VSGLHSKLDRKKAVDQ-----HNAEAQD 532
Query: 1266 INTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLAR 1325
I ++L ++E I +Q K + E +T+ L + S TT+A
Sbjct: 533 IFGKNLNSLFNNMEELIKDGSSKQ------KAMLEVHKTLFGNLLSSSVSALDTITTVA- 585
Query: 1326 IEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSK 1385
+ SLT +N+ T ++ + LKE ++LA ES++
Sbjct: 586 ------------------LGSLTSIPENVST--HVSQIFNMILKE---QSLAA--ESKTV 620
Query: 1386 QEQSLNMKEKDNETTKIVSEMEQF-KPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK 1444
++ +N+ + D ++S +E P ++L+I ++ + K D+++ KE
Sbjct: 621 LQELINVLKTD-----LLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKEL 675
Query: 1445 DDLQRLQEVLQSESDQLKEN-IKEIVAKHLE----TEEELKVAHCCLKEQEETINELRVN 1499
D +L + +L+EN I +V + TE+ + +E + +N
Sbjct: 676 DGFL---SILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTER 732
Query: 1500 LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQF-KEHRK 1558
E + IQK L ++ + +Q K ++I K + K ++ EL+ F +E K
Sbjct: 733 FCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTK 792
Query: 1559 AKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVA 1618
+ +++ + L QE+++ + + + ER+Q N E+V+
Sbjct: 793 LVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVS 852
Query: 1619 KMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKL---NLENIETENIRLTQI-- 1673
+ E+ + K EK I + + KL NLE ET I LT++
Sbjct: 853 QCCEASSSDIT-EKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNC 911
Query: 1674 -LHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKE 1732
L ++L ++ T +S + R + +E+L + + R ++ E L +++
Sbjct: 912 FLEQDL-KLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKR--KQPELLMMLNCSENN 968
Query: 1733 HQETI---DKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789
+ETI D ++ + T E + + ++ D + + + +H KE +
Sbjct: 969 KEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKK-SHGKDKENRGI 1027
Query: 1790 IDKLRGIVSEKTDKL 1804
R V E T+ L
Sbjct: 1028 NTLERSKVEETTEHL 1042
Score = 66.6 bits (161), Expect = 3e-10
Identities = 108/543 (19%), Positives = 234/543 (43%), Gaps = 66/543 (12%)
Query: 1387 EQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQ--ESHDEMKSVAKEK 1444
E++ ++ ++++ T+I+ + + + S + I L L + L E K++ +
Sbjct: 304 ERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKP 363
Query: 1445 DDLQRL-QEVLQSESDQLKENIKEIVAKHLE------TEEELKVAHCCLKEQEETINELR 1497
+ Q+L ++ L E + E +K +A E +EE +V L QEE I EL
Sbjct: 364 EVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELI 423
Query: 1498 VNLSEKETEISTI-------QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNEL 1550
+ E E++ + + +L+ LQNK QE+ ++ ++ V+E+
Sbjct: 424 EKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYIT- 482
Query: 1551 KQFKEHRKAKDSALQSIESKMLE----LTNRLQESQEEIQIMIKEKEEMKRV-------Q 1599
SAL+S E K+ + L N ++E+ +++ + + + K V Q
Sbjct: 483 -----------SALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQ 531
Query: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN 1659
+ + L N +E++ Q+ + K N + ++ + +
Sbjct: 532 DIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTS 591
Query: 1660 L-ENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVER-DQLKENLRETITRDL 1717
+ EN+ T ++QI + L+E + + L+ + LK + L+ L T+ L
Sbjct: 592 IPENVSTH---VSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSIL 648
Query: 1718 EKQEELKIVHMHLKEHQETID----KLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773
+ +LK + + I+ +L G +S N + +Q++ S + Q +
Sbjct: 649 KINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLT 708
Query: 1774 EELR-IAHMHLKEQQETIDKLRGIVSEK----TDKLSNMQKDLENSNAKLQEKIQELKAN 1828
E+L+ I H +E + KL + +E+ +K N+QK L + +Q+K +++
Sbjct: 709 EDLKTIKQTHSQE----LCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDI--- 761
Query: 1829 EHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVM 1888
+ K +QK ++ + +++++ + +KL E++ + KL+ NLE++
Sbjct: 762 ------VNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQET 815
Query: 1889 KER 1891
++R
Sbjct: 816 EQR 818
Score = 53.5 bits (127), Expect = 3e-06
Identities = 160/866 (18%), Positives = 339/866 (39%), Gaps = 87/866 (10%)
Query: 1668 IRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVH 1727
+ L +I +E L ++ + + + V E L++ D N R I + LE+ +
Sbjct: 158 VSLLEIYNEELFDLLNPSSD------VSERLQMFDDP--RNKRGVIIKGLEE------IT 203
Query: 1728 MHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDA----LKAQDLKIQEELRIAHMHL 1783
+H K+ I + + N HS + +K + +E ++I ++L
Sbjct: 204 VHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNL 263
Query: 1784 KEQ--QETIDKLRGIVSEKTDKLSNMQKDLENSN---AKLQEKIQELKANEHQLITLKKD 1838
+ E I + G V ++ + N+ + L L E+ + E +L + +D
Sbjct: 264 VDLAGSENIGR-SGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQD 322
Query: 1839 VNETQKKVSEMEQLKKQIKDQSLTLSKLEI----ENLNLAQKLHENLEEMKSVMKERDNL 1894
+ + S + + + TLS LE +N+ ++++ L + + + + +
Sbjct: 323 SLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEI 382
Query: 1895 RRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQI 1954
R++ L R++ + E R + + ++ +++ E E + + E+++ T
Sbjct: 383 ERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV--ELIEKIGAVEEELNRVTELF 440
Query: 1955 SDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ 2014
D + +LD+ K +LQ K QEL+ + L K + + +E +++ +
Sbjct: 441 MDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLL 500
Query: 2015 SVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMI--ARDRQN 2072
+ + + LH L+ + V + E + I + + E+I +Q
Sbjct: 501 NTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDI---FGKNLNSLFNNMEELIKDGSSKQK 557
Query: 2073 HQVKPEK----RLLSDGQQHL----TESLREKCSRIKELLKRYSEMDDHYECLNRLSLDL 2124
++ K LLS L T +L S + + S++ + L SL
Sbjct: 558 AMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFN--MILKEQSLAA 615
Query: 2125 EKEIEFQKELSMRVKANL--SLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTK 2182
E + Q EL +K +L SL + + + + N + F K L+ K
Sbjct: 616 ESKTVLQ-ELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIF-------KTSLTVADK 667
Query: 2183 IKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEI 2242
I++++ E + + E Q+ + + Q+ C + +L+ +K H +E+
Sbjct: 668 IEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIK-----QTHSQEL 722
Query: 2243 LK--DFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVN 2300
K + F +++ + + + +K ++ E N + + + N + + + C +
Sbjct: 723 CKLMNLWTERFCALEEKCENI---QKPLSSVQE---NIQQKSKDIVNKMTFHSQKFCADS 776
Query: 2301 NFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVN 2360
+ F+ + E T+ E S S + +L+ + ++ E+ ++ T +T S V+
Sbjct: 777 DGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNT-RTVYFSEQWVS 835
Query: 2361 PTTQDNKNPH----VTSRATQLTTEKIRELENSLHEAKESAMH--------KESKIIKMQ 2408
+ + H V S+ + ++ I E + A E + E K+I
Sbjct: 836 SLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQN 895
Query: 2409 KELEVTNDI-IAKLQAKVHESNKCLEKTKETIQ---VLQDKVALGAKPYKEEIEDLKMKL 2464
EL T I + KL + + K T T Q L + +P + ++ LK K
Sbjct: 896 LELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRK- 954
Query: 2465 VKIDLEKMKNAKEFEKEISATKATVE 2490
+ +L M N E KE + VE
Sbjct: 955 -QPELLMMLNCSENNKEETIPDVDVE 979
Score = 39.3 bits (90), Expect = 0.053
Identities = 38/189 (20%), Positives = 78/189 (41%), Gaps = 2/189 (1%)
Query: 2316 EFEERSATISKEWEQDLKSLKEKNEKLF-KNYQTLKTSLASGAQVNPTTQDNKNPHVTSR 2374
E+ R+ I + E + K K+ K + + + LK LA+ + N +N V S
Sbjct: 351 EYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSG 410
Query: 2375 ATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEK 2434
+ E+I EL + +E + + EL+ + ++ + K L++
Sbjct: 411 KLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQE 470
Query: 2435 TKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKE 2494
TK + V ++ + + +E++ D KL+ E K+ ++ KA ++ E
Sbjct: 471 TKLQL-VKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAE 529
Query: 2495 VIRLLRENL 2503
+ +NL
Sbjct: 530 AQDIFGKNL 538
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 250 bits (638), Expect = 2e-65
Identities = 365/1599 (22%), Positives = 703/1599 (43%), Gaps = 234/1599 (14%)
Query: 124 EFLLRVSYMEIYNETITDLLCGT----QKMKPLIIREDVNRNVYVADLTEEVVYTSEMAL 179
+F + VS+ EIYNE I DL QK K L + +DV ++ DL V S+ A
Sbjct: 268 KFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAY 327
Query: 180 KWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGS 239
+ + G K + TK+N SSRSH+IF + + E E S ++VS L+L DLAGS
Sbjct: 328 RLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDSEMSRV---IRVSELSLCDLAGS 384
Query: 240 ERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGF---INYRDSKLTRILQNSL 296
ER +T G RL+E NIN SL LG+ I L + + F + +R+SKLT Q+
Sbjct: 385 ERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFF 444
Query: 297 GGNAKTRIICTITP--VSFDETLTALQFASTAKYMKNTPYVNEVSTDEAL---LKRYRKE 351
G K +I I+ +++DETL L+F++ A+ + +N S+ E L +K +
Sbjct: 445 NGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLN--SSQEKLFGPVKSSQDV 502
Query: 352 IMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQN-EKIENL-TRMLVTSSSLTL 409
+D + ++++ RA ++ L L+E++DL+++++N E+ +N+ T++L TL
Sbjct: 503 SLDSNSNSKILNVK-RATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTL 561
Query: 410 QQE---LKAKRKRRVTWCLGKINKM----KNSNYADQFNIPTNITTKTHKLSINLLREID 462
++ + + KR++ + + K K +F I +T + + +
Sbjct: 562 EENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFK 621
Query: 463 ESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDN----LVLDYEQLR 518
E++ E ++ + I + K +E ++ + + + + L L + Q++
Sbjct: 622 ETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIK 681
Query: 519 TE--KEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENE 576
E K + EL +K K +L +R+ + D +Q + E SN K + ++ + ++L N
Sbjct: 682 AELAKTKGEL-IKTKEELK-----KRENESDSLIQEL-ETSNKKIITQNQRI--KELINI 732
Query: 577 LSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSL--------ESIEDPKQMKQTLF 628
+ K + + E + L+ ++++ N K D S + E++E PK K +
Sbjct: 733 IDQKEDTINE----FQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKIC 788
Query: 629 ---------DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAK 679
+ + AK+ S + S E ++K +E+ ++E DI++ Q E
Sbjct: 789 SERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIE-DIRVLQENNEGL 847
Query: 680 KKMQVDLEKELQSAFNEITKLTSLI---DGKVPKDLLCNLELEGKITDLQK-------EL 729
+ + +E EL++ E +L I ++ NL L ++ +Q EL
Sbjct: 848 RAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAEL 907
Query: 730 NKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFS-EVVHKE 788
+ + +N+ E+++ LS +E+E + I + ++ ++ ++ D+L + + V +
Sbjct: 908 HVQKSKNQEQEEKIMKLS------NEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQI 961
Query: 789 SRVQGL-LEEI--GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845
S + L L ++ G +D+L TQ + D ++ +Q + ++E R N
Sbjct: 962 SNIDLLNLRDLSNGSEEDNLPNTQLDLLGND---------YLVSKQVKEYRIQEPNREN- 1011
Query: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLEN-RDSTLQ 904
F SS+ A+ E + +K+ +++E ++E+L+ +++ +D +
Sbjct: 1012 ----------SFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNR 1061
Query: 905 TVERE----KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
E+E L+ EK + ++++K QEK+ +Q +E + S++ V
Sbjct: 1062 LKEKEHKNQDDLLKEK-ETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYK 1120
Query: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
++L LE+ K L+ I E+ S L +E N E ++ Q + +D
Sbjct: 1121 AKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQD---SVKNTKD 1177
Query: 1021 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE--------LQQMLESVIAEKEQLKTD 1072
L K + + ++ + + L +E+ E L++ L + A + LK D
Sbjct: 1178 LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKAD 1237
Query: 1073 LKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEK 1132
L+ E + +E+L ++K+ Q+ V+ ++ E +L R ++ E+E+K +
Sbjct: 1238 LQRKEEDYADLKEKLTDAKKQIKQVQKEVS-----VMRDEDKLLRI--KINELEKKKNQC 1290
Query: 1133 SQQLQEKQQQLLNVQEEMS--EMQKKINEIENLKNELKNKE-------LTLEHMETERLE 1183
SQ+L KQ+ + ++E+++ ++++ I + E +L KE +TLE E ++E
Sbjct: 1291 SQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVE 1350
Query: 1184 LAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIH 1243
Q L EEV+ + E + KE ET+ +
Sbjct: 1351 QDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSN---------------------- 1388
Query: 1244 LKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV-----KEV 1298
KEH+ D L + + + + Q K EE +L + + N+ K+
Sbjct: 1389 -KEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKY 1447
Query: 1299 SETQE----TMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354
+E +E NE+E+LT Q T KDS L + ER +L + + + S ++DN
Sbjct: 1448 AEDRERFFKQQNEMEILTAQLTEKDS-DLQKWREERDQLVAALEIQLKALISSNVQKDN- 1505
Query: 1355 KTIKEALEVKHDQLKEHIRETL---AKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKP 1411
+ +QLK I ET +I + + K+ S + + E E+ + K
Sbjct: 1506 ---------EIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKI 1556
Query: 1412 KDSALL-------------------RIEIEMLGLS-KRLQESHDEMKSVAKEKDDLQRLQ 1451
+D +++ +EI+ L ++ H + K R +
Sbjct: 1557 EDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKR 1616
Query: 1452 EVLQSESDQLK-ENIKEIVA-----------KHLETEEELKVAHCCLKEQEETINELR-- 1497
+ + E D +K EN K ++ ++E KVA ++ + LR
Sbjct: 1617 KSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVA---IRPSSKKTYSLRSQ 1673
Query: 1498 -----VNLSEKETEISTIQK---QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNE 1549
VNL+ K+ E T+QK L+ LQ+K ++I E + + +E V++
Sbjct: 1674 ASIIGVNLATKKKE-GTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQ 1732
Query: 1550 LKQFKEHRKAKDSALQS---IESKMLELTNRLQESQEEI 1585
K+ K RK S + S I +++ + +++ES +I
Sbjct: 1733 PKRAK--RKLYTSEISSPIDISGQVILMDQKMKESDHQI 1769
Score = 173 bits (439), Expect = 2e-42
Identities = 318/1594 (19%), Positives = 665/1594 (41%), Gaps = 235/1594 (14%)
Query: 9 VCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDG--------------SKSFNFDRVFH 54
VC+R+RP E+ L V+ V+ + ++ F+F +VF
Sbjct: 61 VCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKVFG 120
Query: 55 GNETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIF 114
T K ++ + ++G + IF YG T SGKTYT G+E+++G++PR ++ +F
Sbjct: 121 PATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLF 180
Query: 115 ----------QKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYV 164
+K RE+L S E E I +++K + + D + +Y
Sbjct: 181 DSLQERLYTKMNLKPHRSREYLRLSSEQE--KEEIASKSALLRQIKEVTVHNDSDDTLY- 237
Query: 165 ADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRS---------------HTIFRM 209
LT + SE E + Y + +N +S + +F
Sbjct: 238 GSLTNS-LNISEFE-------ESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVP 289
Query: 210 ILESREKGEPSNCEGSVK----VSHLNLVDLAGSERAAQTGAAGVR------LKEGCNIN 259
+ +K + VK + L + ++ S+ A + G++ K +
Sbjct: 290 VSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASS 349
Query: 260 RSLFILGQVIKKLSDGQVGGFINYRD--------SKLTRILQNSLGGNAKTRIICTITPV 311
RS I I ++ D ++ I + S+ T QN +T I T + +
Sbjct: 350 RSHSIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINT-SLL 408
Query: 312 SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAM 371
+ + + L+ + +K+ ++ P+ E+ L Y + + K ++ + + +
Sbjct: 409 TLGKCINVLKNSEKSKFQQHVPF------RESKLTHYFQSFFNGKGKICMI-VNISQCYL 461
Query: 372 EKDQLAQLLEEKDLLQKV-----QNEKIENLTRMLVTSSSLTLQQELKAK----RKRRVT 422
D+ +L+ + QKV N E L + +S ++L +K ++ ++
Sbjct: 462 AYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATIS 521
Query: 423 WCLGKINKMKNSNYADQF-NIPTNITTKTHKLSINLLREIDESVCSES-DVFSNTLDTLS 480
W + M++ + ++ N +T L +L + ++E+ S + LD +
Sbjct: 522 WENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIE 581
Query: 481 EIEWNPATKLLNQENIESELN-SLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEA 539
+++ KL+N++ + L +R + Y R E + E L+E+ L+ E
Sbjct: 582 DLK----KKLINEKKEKLTLEFKIREEVTQEFTQYWAQR-EADFKETLLQEREILE--EN 634
Query: 540 LERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYID 599
ER+ ++ K+LV + + ++ ++KV E E+ L+
Sbjct: 635 AERR------------LAIFKDLVGKCDTREEAAKDICATKV----ETEEATACLE---- 674
Query: 600 SQKLENIKMDLSYSL-ESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKEL 658
K IK +L+ + E I+ +++K+ +++++ + + + + ++N +++KEL
Sbjct: 675 -LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQN----QRIKEL 729
Query: 659 ATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAF--NEITKLTSLIDGKVPKDLLCNL 716
Q E+ I +Q +L+ +++ F N+ +SLI + L+CN
Sbjct: 730 INIIDQKEDTINEFQ-----------NLKSHMENTFKCNDKADTSSLI---INNKLICNE 775
Query: 717 ELEGKITDLQK--ELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIIT 774
+E K K V ENE ++E K V E Q KSEE+
Sbjct: 776 TVEVPKDSKSKICSERKRVNENELQQDE----PPAKKGSIHVSSAITEDQKKSEEVRPNI 831
Query: 775 SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834
+E + ++ L E + L T ++ K+ +E + F+Q+
Sbjct: 832 AEIED-----------IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELS 880
Query: 835 MVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE 894
+ ++N + LSKE Q+ S+ EL + + QE+ ++ + NE+E
Sbjct: 881 LSEKKN-------LTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATR 933
Query: 895 QLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQE-SLQIERDQLKSDIH 953
+ N S ++ + T I E +TL+ V ++ DL L++ S E D L +
Sbjct: 934 SITNNVSQIKLMH---TKIDE--LRTLDSVSQIS--NIDLLNLRDLSNGSEEDNLPNTQL 986
Query: 954 DTVNMNIDTQEQLR-------NALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKD 1006
D + + +Q++ N S E I +I + S+ H E + +
Sbjct: 987 DLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIE 1046
Query: 1007 EFQQKMVGI-DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAE 1065
+ Q ++ G D+ L+ K + +K+ E + QQ K +QEKN + + E
Sbjct: 1047 KLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLK--EELQEKNVTLDVQIQHVVE 1104
Query: 1066 KEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEV 1125
++ ++L + + +EL + + K + A+ + ++KE + + L E
Sbjct: 1105 GKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEF 1164
Query: 1126 EEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERL--E 1183
+E L++ + ++ + L ++EE++++ + ++++L +LK +E ETE+L E
Sbjct: 1165 QEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLL-QLKEEEEETNRQETEKLKEE 1223
Query: 1184 LA-------------QKLNENYEEVK-SITKERKVLKELQKSFETERDH---LRGYIREI 1226
L+ Q+ E+Y ++K +T +K +K++QK RD LR I E+
Sbjct: 1224 LSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINEL 1283
Query: 1227 EATGLQTKEELKIAH---IHLKEH------QETIDELRR-----SVSEKTAQIINTQDLE 1272
E Q +EL + LKE +E I + R +V EK + + E
Sbjct: 1284 EKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEE 1343
Query: 1273 KSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLR 1332
+ T+++++ + + +E+ E+ + +E N+LE Q + K+ + +
Sbjct: 1344 QEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTN 1403
Query: 1333 LNEKFQESQEEI-----KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387
L ++ QES+++ K L ++ + KEA +++ ++K++ + ++ +
Sbjct: 1404 LQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEI 1463
Query: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447
+ + EKD++ K E +Q A L I+++ L + S ++ +++
Sbjct: 1464 LTAQLTEKDSDLQKWREERDQL----VAALEIQLKAL------------ISSNVQKDNEI 1507
Query: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKV 1481
++L+ ++ SE+ +++ I +I K + + + K+
Sbjct: 1508 EQLKRII-SETSKIETQIMDIKPKRISSADPDKL 1540
Score = 147 bits (370), Expect = 2e-34
Identities = 333/1778 (18%), Positives = 732/1778 (41%), Gaps = 263/1778 (14%)
Query: 845 QEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEM-EQLKEQLENRDSTL 903
Q + +L K + + G + +Y Q +E + LN + + L+E+L + +
Sbjct: 135 QPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLFDSLQERLYTKMNLK 194
Query: 904 QTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESL-QIERDQLKSDIHDTVNMNIDT 962
RE ++ + QEK+++ L QI+ + +D DT+ ++
Sbjct: 195 PHRSREYLRLSSE------------QEKEEIASKSALLRQIKEVTVHNDSDDTLYGSLTN 242
Query: 963 QEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLE 1022
+ ES+K +++ + + I V + N + V + K +
Sbjct: 243 SLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYN-----EYIYDLFVPVSSK--FQ 295
Query: 1023 AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIE 1082
+ L+ DVK I+ + I + + E ++L+ I + T L N
Sbjct: 296 KRKMLRLSQDVKGYSFIKDLQWI--QVSDSKEAYRLLKLGIKHQSVAFTKLN-NASSRSH 352
Query: 1083 NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQ 1142
+ +++L E + ++ + ELS CD LA E +K +++ E+ ++
Sbjct: 353 SIFTVKILQIEDSEMSRVI---------RVSELS-LCD-LAGSERTMKTQNEG--ERLRE 399
Query: 1143 LLNVQEEMSEMQKKINEIEN-----LKNELKNKELTLEHMETE----RLELAQKLNEN-- 1191
N+ + + K IN ++N + + +E L H + ++ +N +
Sbjct: 400 TGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQC 459
Query: 1192 ---YEEVKSITKERKVLKEL--QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLK- 1245
Y+E ++ K + +++ + + ++ L G ++ + L + KI ++
Sbjct: 460 YLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRAT 519
Query: 1246 -EHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQET 1304
+ ++++L + ++ N ++ + TKL +E + + L K +E
Sbjct: 520 ISWENSLEDLMED-EDLVEELENAEETQNVETKLLDE-----DLDKTLEENKAFISHEEK 573
Query: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQES-QEEIKSLTKERDNLKTIKEALEV 1363
L+L+ + L + E+L L K +E +E +R+ KE L
Sbjct: 574 RKLLDLIEDLKKK-----LINEKKEKLTLEFKIREEVTQEFTQYWAQRE--ADFKETLLQ 626
Query: 1364 KHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423
+ + L+E+ LA ++ K + + KD TK+ +E A +E++
Sbjct: 627 EREILEENAERRLAIFKDLVGKCD-TREEAAKDICATKVETE--------EATACLELKF 677
Query: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAH 1483
+ L ++ E+ K K++L++ + S +L+ + K+I+ ++ +E + +
Sbjct: 678 NQIKAELAKTKGEL---IKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINI-- 732
Query: 1484 CCLKEQEETINELRVNLSEKETEISTIQKQLEA---INDKLQNKIQEIYEKEEQFNIKQI 1540
+ ++E+TINE + S E K + IN+KL E E + K
Sbjct: 733 --IDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLI--CNETVEVPKDSKSKIC 788
Query: 1541 SEVQEKVNELKQFKEHRKAK------DSALQSIESKMLELTNRLQESQEEIQIMIKEKEE 1594
SE +++VNE + ++ AK SA+ + K E+ + E E+I+++ + E
Sbjct: 789 SE-RKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEI-EDIRVLQENNEG 846
Query: 1595 MKR----VQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA-VNETQEK----MCE 1645
++ ++ L+ E+++ E K+IV +E E + L ++ V + Q + E
Sbjct: 847 LRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAE 906
Query: 1646 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKV----- 1700
+ K + + Q+ + + E T+ + N+ +++ + + D+LR+++ ++
Sbjct: 907 LHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDL 966
Query: 1701 ----------ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNE 1750
E D L + + D +++K + + + + E+ E
Sbjct: 967 LNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKE 1026
Query: 1751 ISNMQKDLEHSNDALKAQDLKIQEELR---IAHMHLKEQQETIDKLRGIVSEKTDKLSNM 1807
I H + L+ Q K+Q E++ + LKE++ ++ EK + +
Sbjct: 1027 IVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQD--DLLKEKETLIQQL 1084
Query: 1808 QKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE 1867
+++L+ N L +IQ + + L L + V + K+ E+E + + K + +KLE
Sbjct: 1085 KEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLE 1144
Query: 1868 ---IENLNLAQKLHENLEE----MKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL 1920
+E ++ KL NL+E ++ +K +L E LK E QL +LQ+ K L
Sbjct: 1145 QDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHL-L 1203
Query: 1921 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL 1980
++++E + + +++ +KL+E++S + + +++ DL + +++ ++L +
Sbjct: 1204 QLKEEEE------ETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKK 1257
Query: 1981 QLLRVKEDVNMSHK-------KINEMEQLKKQFEAQ-NLSMQSVRMDNFQL-TKKLHESL 2031
Q+ +V+++V++ KINE+E+ K Q + ++ ++++ QL +K+ E++
Sbjct: 1258 QIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAI 1317
Query: 2032 EEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTE 2091
++ K+ + +I E ++M TL E ++ QV+ Q + E
Sbjct: 1318 QQYERACKDLNVKEKIIEDMRM-------TLEE-----QEQTQVE---------QDQVLE 1356
Query: 2092 SLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKH 2151
+ E+ R+ L+++ E + E N + E E N + T
Sbjct: 1357 AKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHE------------NNTDVLGKLTNL 1404
Query: 2152 IEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKEL-LI 2210
++L + Q+ + + + +++ +++ + + +++ + K+ D ++Q E+ ++
Sbjct: 1405 QDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEIL 1464
Query: 2211 KIQHLQQDCDVPS-RELRD-------------LKLNQNMDLHIEEILKDFSESEFPSIKT 2256
Q ++D D+ RE RD + N D IE++ + SE+ I+T
Sbjct: 1465 TAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETS--KIET 1522
Query: 2257 EFQQVLSNR---KEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNE 2313
+ + R + + E L+T F+I + N+I E
Sbjct: 1523 QIMDIKPKRISSADPDKLQTEPLSTSFEISR--------------------NKI-----E 1557
Query: 2314 STEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTS 2373
S +S E +Q + K + E F Q K ++ P T K P
Sbjct: 1558 DGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTV--KIPKARK 1615
Query: 2374 RATQLTTEKIRELENS------------LHEAKESAMHKESKIIKMQKELEVTNDIIAKL 2421
R + E + + EN + + + S++ KE K+ + + +
Sbjct: 1616 RKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYS---LRS 1672
Query: 2422 QAKVHESNKCLEKTKETIQ-----------VLQDKVALGAKPYKEEIEDLKMKLVKIDLE 2470
QA + N +K + T+Q +LQ K AK E + K+ V+ E
Sbjct: 1673 QASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSK----AKKIIETMSSSKLSNVEASKE 1728
Query: 2471 KMKNAKEFEKEI--SATKATVEYQKEVIRLLRENLRRS 2506
+ K ++++ S + ++ +VI L+ + ++ S
Sbjct: 1729 NVSQPKRAKRKLYTSEISSPIDISGQVI-LMDQKMKES 1765
Score = 117 bits (294), Expect = 1e-25
Identities = 221/1153 (19%), Positives = 479/1153 (41%), Gaps = 179/1153 (15%)
Query: 1485 CLKEQEETINELRVN-LSEKETEISTIQKQLEAI----------------NDKLQNKIQE 1527
C +ET+N L+ + +++K T+ E + N K+ N +
Sbjct: 459 CYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRA 518
Query: 1528 IYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQI 1587
E +++ + E ++ V EL+ +E Q++E+K+L+ L ++ EE +
Sbjct: 519 TISWEN--SLEDLMEDEDLVEELENAEE--------TQNVETKLLD--EDLDKTLEENKA 566
Query: 1588 MIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIE 1647
I +E+ K + +++ + E +++ + K +E +F + A E K E
Sbjct: 567 FISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFK----E 622
Query: 1648 HLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707
L ++ E + N E L E + + + + L+++ +Q+K
Sbjct: 623 TLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKA 682
Query: 1708 NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKA 1767
L +T ++ +EELK ++ NE ++ ++LE SN +
Sbjct: 683 ELAKTKGELIKTKEELK---------------------KRENESDSLIQELETSNKKIIT 721
Query: 1768 QDLKIQEELRIAHMHLKEQQETIDKLRGIVSE-----KTDKLSNMQKDLENSNAKLQEKI 1822
Q+ +I+E + I + ++++TI++ + + S K + ++ + N+ E +
Sbjct: 722 QNQRIKELINI----IDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETV 777
Query: 1823 QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLE 1882
+ K ++ ++ + +K VNE +E++Q + K S+ +S E+ ++++ N+
Sbjct: 778 EVPKDSKSKICSERKRVNE-----NELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIA 832
Query: 1883 EMKSVMKERDN---LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM----LSKE 1935
E++ + ++N LR T++ E KE E + + QQEL + LSKE
Sbjct: 833 EIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKE 892
Query: 1936 HKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKK 1995
++ I+E +Q S Q+ +K + K E++ + + + H K
Sbjct: 893 VQQIQSNYDIAIAELHVQKSKNQEQEEK----IMKLSNEIETATRSITNNVSQIKLMHTK 948
Query: 1996 INEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMER 2055
I+E+ L + N+ + ++R L EE + + D L
Sbjct: 949 IDELRTLDSVSQISNIDLLNLR--------DLSNGSEEDNLPNTQLDLLGN--------- 991
Query: 2056 DQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYE 2115
++++ + ++++ R + E++ E+C KE++K S+ E
Sbjct: 992 -------DYLVSKQVKEYRIQEPNR--ENSFHSSIEAIWEEC---KEIVKASSKKSHQIE 1039
Query: 2116 CLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKY 2175
L + L+ E++ K+ + R+K + K+ + L + + +++
Sbjct: 1040 ELEQQIEKLQAEVKGYKDENNRLKEK------EHKNQDDLLKEKETLIQQLKEELQEKNV 1093
Query: 2176 VLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNM 2235
L + E ++++ K KEL ++ + +C ++ +D+ +++
Sbjct: 1094 TLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESI 1153
Query: 2236 DLHIEEILKDFSESEFPSIKTEFQ---QVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKE 2292
L +E LK+F E S+K + L ++E+TQ N D++ L ++E
Sbjct: 1154 ILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLT----NNLQDMKHLLQLKEEE 1209
Query: 2293 NDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTS 2352
+ NR + TE + + S Q+LK+ ++ E+ +Y LK
Sbjct: 1210 EE---------TNR------QETEKLKEELSASSARTQNLKADLQRKEE---DYADLKEK 1251
Query: 2353 LASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELE 2412
L + Q K V +L KI ELE ++ + K+ I +++++L
Sbjct: 1252 LTDAKK--QIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLN 1309
Query: 2413 VTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL-----VKI 2467
KV E+ + E+ + + V ++K+ IED++M L ++
Sbjct: 1310 ---------NQKVEEAIQQYERACKDLNV-KEKI----------IEDMRMTLEEQEQTQV 1349
Query: 2468 DLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQD--TSVISEHT----DP 2521
+ +++ AK E E AT+ +++++ L +N +RS + + T V+ + T +
Sbjct: 1350 EQDQVLEAKLEEVERLATELE-KWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDEL 1408
Query: 2522 QPSNKPLTCGGGSGIVQNTKALIL--KSEHIRLEKEISKLKQQNEQLIKQKNE---LLSN 2576
Q S + + + + ++E+IR KE+ K + E+ KQ+NE L +
Sbjct: 1409 QESEQKYNADRKKWLEEKMMLITQAKEAENIR-NKEMKKYAEDRERFFKQQNEMEILTAQ 1467
Query: 2577 NQHLSNEVKTWKE 2589
++++ W+E
Sbjct: 1468 LTEKDSDLQKWRE 1480
Score = 77.8 bits (190), Expect = 1e-13
Identities = 258/1254 (20%), Positives = 502/1254 (40%), Gaps = 279/1254 (22%)
Query: 1504 ETEISTIQKQLEAINDKLQNKIQ-----EIYEKEEQFNIKQISEVQEKVNE---LKQFKE 1555
E I + + L + D LQ ++ + + E + E +E ++ L+Q KE
Sbjct: 166 EENIGILPRTLNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKE 225
Query: 1556 ---HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEA--------LQI 1604
H + D+ S LTN L S+ E I E+ + +I
Sbjct: 226 VTVHNDSDDTLYGS-------LTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEI 278
Query: 1605 ERDQLKENTKEIVAKMKE------SQE-KEYQFLK---MTAVNETQE--KMCEIEHLKEQ 1652
+ + + + +K ++ SQ+ K Y F+K V++++E ++ ++ +
Sbjct: 279 YNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQS 338
Query: 1653 FETQKLNLENIETENIRLTQILHENLEEMRSVTKERD----DLRSVEETLKVERDQLKEN 1708
KLN + + +I +IL EM V + + DL E T+K + + E
Sbjct: 339 VAFTKLNNASSRSHSIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEG--ER 396
Query: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
LRET + K +++ LK ++ S+ + + L H +
Sbjct: 397 LRETGNINTSLLTLGKCINV-LKNSEK---------SKFQQHVPFRESKLTHYFQSFFNG 446
Query: 1769 DLKIQEELRIAHMHLKEQQETIDKLR-GIVSEKT---DKLSNMQKDLENSNAKLQEKIQE 1824
KI + I+ +L ET++ L+ +++K D L++ Q+ L Q+ +
Sbjct: 447 KGKICMIVNISQCYLA-YDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLD 505
Query: 1825 LKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEM 1884
+N K +N + +S L+ ++D+ L +E L EN EE
Sbjct: 506 SNSNS-------KILNVKRATISWENSLEDLMEDEDL------VEEL-------ENAEET 545
Query: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKA--------RDLEIQQELKTARMLSKEH 1936
++V ET L+ D L ++L+E KA + L++ ++LK + K+
Sbjct: 546 QNV-----------ETKLLDED-LDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKE 593
Query: 1937 KETVD-KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKK 1995
K T++ K+RE+++++ Q Q++ D + LQ++ + E +L K+ V K
Sbjct: 594 KLTLEFKIREEVTQEFTQYW-AQREADFKETLLQEREILEENAERRLAIFKDLVG----K 648
Query: 1996 INEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI-VAKERDELRRIKESLKME 2054
+ E+ K A +++ + T L +I+ +AK + EL + KE LK
Sbjct: 649 CDTREEAAKDICA-------TKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKR 701
Query: 2055 RDQFIATLREMIARDR----QNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEM 2110
++ + ++E+ ++ QN ++K ++ + + E K S ++ K +
Sbjct: 702 ENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLK-SHMENTFKCNDKA 760
Query: 2111 DDHYECLNRLSLDLEKEIEFQKELSMRV---KANLSLPYLQTK---------HIEKLFTA 2158
D +N L + +E K+ ++ + ++ LQ H+ T
Sbjct: 761 DTSSLIINN-KLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITE 819
Query: 2159 NQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF----EMDFIDEVEKQKELLIKIQH 2214
+Q+ S E + +++ + ++ +E +E + F E + +E E++ EL +I H
Sbjct: 820 DQKKSEEVRPNIAEIEDI-----RVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVH 874
Query: 2215 LQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEE 2274
QQ+ + SE + ++ E QQ+ SN L
Sbjct: 875 FQQELSL-------------------------SEKKNLTLSKEVQQIQSNYDIAIAELH- 908
Query: 2275 WLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKS 2334
++K KN Q++ ++I +++N +I N ++ + I +L++
Sbjct: 909 -------VQKSKN--QEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKID-----ELRT 954
Query: 2335 LKEKNEKLFKNYQTLKT-SLASGAQVN--PTTQDNK--NPHVTSRATQLTTEKIRE--LE 2387
L ++ N L L++G++ + P TQ + N ++ S+ Q+ +I+E E
Sbjct: 955 LDSVSQ--ISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSK--QVKEYRIQEPNRE 1010
Query: 2388 NSLHEAKESAMHK------------------ESKIIKMQKELEVTNDIIAKLQAKVHESN 2429
NS H + E+ + E +I K+Q E++ D +L+ K H++
Sbjct: 1011 NSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQ 1070
Query: 2430 KCLEKTKETI--------------------QVLQDKVAL-----GAKPYKEEIEDLK--- 2461
L K KET+ V++ K AL G YK +I++L+
Sbjct: 1071 DDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETIL 1130
Query: 2462 ----------MKLVKIDLEK-------MKNAKEFEKEI-SATKATVEYQ------KEVIR 2497
KL + LEK +N KEF++ + + K T + KE I
Sbjct: 1131 ETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEIT 1190
Query: 2498 LLRENLRRSQQAQDTSVISEHTDPQPSNK-PLTCGGGSGIVQNTKALILKSEH------- 2549
L NL+ + E T+ Q + K S QN KA + + E
Sbjct: 1191 QLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKE 1250
Query: 2550 ---------IRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKR 2594
+++KE+S ++ +++ L + NEL S E+ K+RT+++
Sbjct: 1251 KLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQEL-DMKQRTIQQ 1303
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 249 bits (637), Expect = 2e-65
Identities = 353/1602 (22%), Positives = 715/1602 (44%), Gaps = 199/1602 (12%)
Query: 517 LRTEKEEMELKLKEKN---DLD-EFEALERKTKKDQEMQLIHEISNLKN--LVKHAEVYN 570
++ K++M L K K+ +L+ E E L K + +I ++ + L++ AE
Sbjct: 31 IKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQ 90
Query: 571 QDLENELSSKVELLREKEDQIKKL--------QEYIDSQK-LENIKMDL-SYSLESIEDP 620
Q L + +++ +E ED + K+ Q +I+ K +EN+K +L + + ED
Sbjct: 91 QCLSLK-KENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDK 149
Query: 621 KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEA-- 678
+++ L +A L+ + F + +K+ +E+ E I Q QL+A
Sbjct: 150 ANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATT 209
Query: 679 --KKKMQVDLE-----------KELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDL 725
KK+ L+ K + S E+ +L ++ +V K+L+C +E K +
Sbjct: 210 DEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEV-KELMCQIEASAK--EH 266
Query: 726 QKELNK--EVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSE 783
+ E+NK E++EN + E + K E+E LRK + +++ I + L E
Sbjct: 267 EAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSI----LLQE 322
Query: 784 VVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFK-TLHMDFEQKYKMVLEENER 842
E V ++ + T +L + S K N K L MD + E E
Sbjct: 323 NTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHERED 382
Query: 843 MNQEI--VNLSKEAQ-----KFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQ 895
+ +I + L+KE Q K S L L + Y +++ REVQ L E Q KE
Sbjct: 383 LEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCY---TVEQHNREVQS-LKEQHQ-KEI 437
Query: 896 LENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEK-------DDLKQLQESLQIE---- 944
E ++ L E+EK + ++Q E+ + L QEK + L+++ E LQ E
Sbjct: 438 SELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGES 497
Query: 945 -----------RDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR 993
+ Q SD+H + Q++LR A ET+N L+ + + +S+
Sbjct: 498 AGKISQEFESMKQQQASDVH-------ELQQKLRTAFTEKDALLETVNRLQGENEKLLSQ 550
Query: 994 NLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKN 1053
+ E K+ ++ V + L ++T + K N + E++ + ++ +
Sbjct: 551 QELVPELENTIKNLQEKNGVYL---LSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSH 607
Query: 1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG 1113
E +E+L +L + +E TI+ EL +EL E +EK+ +K
Sbjct: 608 EEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLE 667
Query: 1114 ELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMS-EMQKKINEIEN--LKNELKNK 1170
+L L+E +E L + + L E+ +L + ++++S +++ +++ E+ LK +
Sbjct: 668 KLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQL 727
Query: 1171 ELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230
E L+ M E+ L KL EN +++QK F + L G+++E+ +
Sbjct: 728 EKKLQLMVEEQDNL-NKLLEN--------------EQVQKLF--VKTQLYGFLKEMGSEV 770
Query: 1231 LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQE 1290
+ EE + ++ ++V E A+I + EK + Q + VL E+E
Sbjct: 771 SEDSEEKDVVNV------------LQAVGESLAKI----NEEKCNLAFQRDEKVLELEKE 814
Query: 1291 LLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350
+K + E E++ + E L + L E E++ L ++ +E Q E ++L +
Sbjct: 815 ----IKCLQE--ESVVQCEEL--------KSLLRDYEQEKVLLRKELEEIQSEKEALQSD 860
Query: 1351 RDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFK 1410
+K E +++ L + E +S+ E+ K++E K + E ++ +
Sbjct: 861 LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKE-KCFIKEHENLKPLLEQKELR 919
Query: 1411 PKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVA 1470
+ + L+ ++ L+K +D + SV +L+ E L+ E + +E I +I
Sbjct: 920 DRRAELILLKD---SLAKSPSVKNDPLSSV----KELEEKIENLEKECKEKEEKINKIKL 972
Query: 1471 KHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYE 1530
++ ++EL + +++ +T+ E +L ++ ++S + L + +N + E +
Sbjct: 973 VAVKAKKELDSS----RKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEK 1028
Query: 1531 KEEQFNI--KQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM 1588
+ EQ ++ ++ + + ++ +L + + + + S +L LQ + + +++
Sbjct: 1029 QSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQ 1088
Query: 1589 IKEKEEMK-RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIE 1647
I E + K V + L+ E+ Q ++ KE + E +E + Q K + Q+ M E+E
Sbjct: 1089 ILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQK--EKKQLQKTMQELE 1146
Query: 1648 HLKEQFETQKLNLENIETENI-RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLK 1706
+K+ + Q+ L N+E + RL + L++ L T + + + +E+ +K+++ Q +
Sbjct: 1147 LVKK--DAQQTTLMNMEIADYERLMKELNQKL------TNKNNKIEDLEQEIKIQK-QKQ 1197
Query: 1707 ENLRETIT---RDLEKQEE--LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761
E L+E IT +++ EE KI + +K +E D + + S ++ +LE S
Sbjct: 1198 ETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQAS-LKGELEAS 1256
Query: 1762 N---DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL 1818
+ K Q +I E H HLK E + ++ L + + A +
Sbjct: 1257 QQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATV 1316
Query: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH 1878
+ + K H ++ +K+ + +Q +E E K++ + + + +L+I+ + L
Sbjct: 1317 TSEFESYKVRVHNVLKQQKNKSMSQ---AETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
Query: 1879 ENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTAR----MLSK 1934
N+ E++++ E D L LER + LQET +++ E++++L + + M+
Sbjct: 1374 INVSELQTLQSEHDTL--------LERH--NKMLQETVSKEAELREKLCSIQSENMMMKS 1423
Query: 1935 EHKETVDKL--REKISEKTI--QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVN 1990
EH +TV +L + ++ + Q+ +Q++ K+ + LQ Q+L K E QL ++K +
Sbjct: 1424 EHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQ---QQLSKMEAQLFQLKNEPT 1480
Query: 1991 MSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLE 2032
+ ++ + LK E +N + +D +T++ E +E
Sbjct: 1481 -TRSPVSSQQSLKNLRERRNTDLP--LLDMHTVTREEGEGME 1519
Score = 233 bits (595), Expect = 1e-60
Identities = 337/1633 (20%), Positives = 736/1633 (45%), Gaps = 207/1633 (12%)
Query: 452 KLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYD--- 508
K +I + +E+++SV D E+E + + EN+++EL ++R+ Y
Sbjct: 97 KENIKMKQEVEDSVTKMGDAHK-------ELEQSHINYVKEIENLKNELMAVRSKYSEDK 149
Query: 509 -NLVLDYEQLRTEKEEMELKLK-EKNDLDEFEALERKTKKDQ---EMQLIH--------- 554
NL E+ + E+ +LK + N D + L+ + +K + E Q+++
Sbjct: 150 ANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATT 209
Query: 555 -----EISNLKNLVK-HAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS-------- 600
++ L+N+++ +++ Y +++ + ++L ++++K+L I++
Sbjct: 210 DEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAE 269
Query: 601 -QKLENIKMDLSYSLESIEDPKQMK-----QTLFDAETVALDAKRESAFLRSENL----E 650
KL +K +L E+ E Q K + L A + A + + L EN
Sbjct: 270 INKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQV 329
Query: 651 LKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPK 710
+ EK+K L T K++E+ + + ++ +++ LE + Q +E ++ K+ +
Sbjct: 330 VNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINE 389
Query: 711 DLLCNLE-------LEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEI 763
LL E L+ ++ L K+ VE++ E++SL E+ +KEI
Sbjct: 390 LLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHN---------REVQSLK---EQHQKEI 437
Query: 764 QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFK 823
+ +E + SEK+KL +QGL E+ + + NY+S + + +
Sbjct: 438 SELNETF-LSDSEKEKLTLMF-----EIQGLKEQCENLQQEKQEAILNYESLREIMEILQ 491
Query: 824 TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ---EKTR 880
T + + + +E E M Q+ + E Q+ + K L LQ EK
Sbjct: 492 T---ELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLL 548
Query: 881 EVQERLNEMEQLKEQLENRDST-LQTVEREKTLITEKLQQTLE-EVKTLTQEKDDLKQLQ 938
QE + E+E + L+ ++ L ++ + T++ E LE ++ +LT+EKDD
Sbjct: 549 SQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKE-----LEGKINSLTEEKDDF---- 599
Query: 939 ESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHME 998
++LK+ + N + + + R LE K+ ++TI S++ ++V+
Sbjct: 600 ------INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQ-YNSELEQKVNELTGGL 652
Query: 999 ENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM 1058
E T + KD+ QK+ + + + +++ + L+A+VK + E+ K+ S EK +L +
Sbjct: 653 EETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVK--SLYEENNKLSS---EKKQLSRD 707
Query: 1059 LESVIAEKEQL-----KTDLKENIEMTIENQEEL-RLLGDE------LKKQQEIVAQEKN 1106
LE +++KE + T L++ +++ +E Q+ L +LL +E +K Q +E
Sbjct: 708 LEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMG 767
Query: 1107 HAIKKEGELSRTCDRLAEVEEKL----KEKSQQLQEKQQQLLNVQEEMSEMQKK-INEIE 1161
+ ++ E + L V E L +EK ++ +++L +++E+ +Q++ + + E
Sbjct: 768 SEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCE 827
Query: 1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRG 1221
LK+ L++ E E++ L ++L E E +++ + +K + E +L
Sbjct: 828 ELKSLLRD-------YEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLI 880
Query: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDEL-RRSVSEKTAQIINTQD-LEKSHTKLQ 1279
+ E+ T +++ + +KEH+ L ++ + ++ A++I +D L KS +
Sbjct: 881 QVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKN 940
Query: 1280 EEIPVLHEEQELLPNV-KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQ 1338
+ + + E +E + N+ KE E +E +N+++L+ + A+ E++ R ++ Q
Sbjct: 941 DPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVK---------AKKELDSSR--KETQ 989
Query: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398
+EE++SL E+D L L + K + E + ++ ++E++ N + + +
Sbjct: 990 TVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIED 1049
Query: 1399 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSES 1458
T+ Q + I + L R++ K + + ++QR + ++ E
Sbjct: 1050 LTR------QLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKEL 1103
Query: 1459 DQLKENIKEIVAKHLETEEELKVAHCCL----KEQEETINELRVNLSEKE------TEIS 1508
+ K ++ + +H T EL+ L K+ ++T+ EL + + + EI+
Sbjct: 1104 EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIA 1163
Query: 1509 TIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISE--VQEKVNELKQFKEHRKAKDSALQS 1566
++ ++ +N KL NK +I + E++ I++ + +QE++ L+ + + K++ ++
Sbjct: 1164 DYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQ 1223
Query: 1567 IESK-MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKE---IVAKMKE 1622
+ K EL + Q + + + K E++ Q+ +++ + QL E T E I +K
Sbjct: 1224 LLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKT 1283
Query: 1623 SQEKEYQFL-----KMTAV-NETQEKMCEIEHLKEQFETQKLNLENI--ETENIRLTQIL 1674
S E+ + L ++TA+ E + E + +FE+ K+ + N+ + +N ++Q
Sbjct: 1284 SAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQ-- 1341
Query: 1675 HENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITR-DLEKQEELKIVHMHLKEH 1733
E +ER+ L + + LK++ + NL+ ++ + E ++ H K
Sbjct: 1342 ----AETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKML 1397
Query: 1734 QETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKL 1793
QET+ K + +L +++++++ ++ E L Q E +
Sbjct: 1398 QETVSK---------------EAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLR-- 1440
Query: 1794 RGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK 1853
+ D++ ++Q++ + LQ+++ +++A QL K+ T+ VS + LK
Sbjct: 1441 ----NSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQL----KNEPTTRSPVSSQQSLK 1492
Query: 1854 KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913
+ ++ L L++ + + + +SV + +E+ L +L+ L
Sbjct: 1493 NLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLW 1552
Query: 1914 ETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQ 1973
+ E+ Q+L + S +H + LRE + I + I+ L KS+ ++ Q
Sbjct: 1553 HAEFTKEELVQKLSSTTK-SADHLNGL--LRETEATNAILMEQIK--LLKSEIRRLERNQ 1607
Query: 1974 ELQKKELQLLRVK 1986
E +K L +K
Sbjct: 1608 EREKSAANLEYLK 1620
Score = 230 bits (587), Expect = 1e-59
Identities = 357/1660 (21%), Positives = 715/1660 (43%), Gaps = 273/1660 (16%)
Query: 740 REEVILLSELKSLPSEVERLRKEIQDK------SEELHIITSEKDKLFSEVVHKESRVQG 793
+++++L+ + KS +E+E+ +E++ K + + +T D L E E +
Sbjct: 35 KKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLS 94
Query: 794 LLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKE 853
L +E K K ++ E + + ++ + Q +N KE
Sbjct: 95 LKKENIKMKQEV------------------------EDSVTKMGDAHKELEQSHINYVKE 130
Query: 854 AQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLI 913
+ + L A++++ S LQ ++++E +N +L EQL+ ++++ V+
Sbjct: 131 IENLKNELMAVRSKYSEDKANLQ---KQLEEAMNTQLELSEQLKFQNNSEDNVK------ 181
Query: 914 TEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESL 973
KLQ+ +E+++ +E+ + LQ+ L D+ K +T QL+N +E+
Sbjct: 182 --KLQEEIEKIRPGFEEQ--ILYLQKQLDATTDEKK-----------ETVTQLQNIIEAN 226
Query: 974 KQH-QETINTLKSKI-------SEEVSRNLHMEENTGETKD-------EFQQKMV----- 1013
QH Q+ IN+L+ ++ EEV + E + + + E ++ +V
Sbjct: 227 SQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEA 286
Query: 1014 ---GIDKKQDLEAKNTQTLTADV-KDNEI--IEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
I KK + E +N + T++ +DN+I I Q F + Q NE + LE + E E
Sbjct: 287 SEKNIQKKYECELENLRKATSNANQDNQICSILLQENTF-VEQVVNEKVKHLEDTLKELE 345
Query: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
+ LK+ E+T N +L+L D + E E+ K EL + V E
Sbjct: 346 SQHSILKD--EVTYMNNLKLKLEMDAQHIKDEFF-HEREDLEFKINELLLAKEEQGCVIE 402
Query: 1128 KLKEKSQQLQEK-----QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERL 1182
KLK + L ++ +Q VQ + QK+I+E+ E L E E+L
Sbjct: 403 KLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELN---------ETFLSDSEKEKL 453
Query: 1183 ELAQKLNENYEEVKSITKERKV-------LKELQKSFETERDHLRGYIREIEATGLQTKE 1235
L ++ E+ +++ +E++ L+E+ + +TE G I + ++ +
Sbjct: 454 TLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQ----EFESMK 509
Query: 1236 ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295
+ + + +H E +LR + +EK A L ++ +LQ E L +QEL+P +
Sbjct: 510 QQQASDVH-----ELQQKLRTAFTEKDA-------LLETVNRLQGENEKLLSQQELVPEL 557
Query: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNE-------KFQESQEEIKSLT 1348
+ + + N + LL S ++ T L +E + L E K + S EE+ +
Sbjct: 558 ENTIKNLQEKNGVYLL---SLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 614
Query: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408
K+ + + + L K +Q ++ E K+ E E++L KEKD K+ M Q
Sbjct: 615 KKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETL--KEKDQNDQKLEKLMVQ 672
Query: 1409 FK--PKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQ--LKEN 1464
K +D +L E++ L ++E ++ EK L R EV S+ + LKE+
Sbjct: 673 MKVLSEDKEVLSAEVKSL---------YEENNKLSSEKKQLSRDLEVFLSQKEDVILKEH 723
Query: 1465 IKEIVAK-HLETEEELKVAHCCLKEQEETI---NELRVNLSEKETEISTIQKQLEAIN-- 1518
I ++ K L EE+ + EQ + + +L L E +E+S ++ + +N
Sbjct: 724 ITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVL 783
Query: 1519 DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI----ESKMLEL 1574
+ + +I E++ ++ +V E E+K +E + L+S+ E + + L
Sbjct: 784 QAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLL 843
Query: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ---EKEYQFL 1631
L+E Q E + + + EMK E ++E L +E+ +S+ EKE F+
Sbjct: 844 RKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFI 903
Query: 1632 K-------MTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE----- 1679
K + E +++ E+ LK+ + +++N +++ + ENLE
Sbjct: 904 KEHENLKPLLEQKELRDRRAELILLKDSL-AKSPSVKNDPLSSVKELEEKIENLEKECKE 962
Query: 1680 -----------------EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722
E+ S KE ++ E+L+ E+DQL ++R+ I + E
Sbjct: 963 KEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI----QGAES 1018
Query: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS----------NDALKAQDLKI 1772
K + + ++ E +D + + + I ++ + L +S N+ L A+ +
Sbjct: 1019 YKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETL 1078
Query: 1773 QEELRIAHMHLKEQQET---IDKLRGIVSEKTDKLSNMQK------DLENSNAKLQEKIQ 1823
Q ++ + + E Q +DK + +EK K +++ +LE +LQ++ +
Sbjct: 1079 QSNAKLLEVQILEVQRAKAMVDK--ELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKK 1136
Query: 1824 ELKANEHQLITLKKDVNET---QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHEN 1880
+L+ +L +KKD +T ++++ E+L K++ +Q LT +I E+
Sbjct: 1137 QLQKTMQELELVKKDAQQTTLMNMEIADYERLMKEL-NQKLTNKNNKI----------ED 1185
Query: 1881 LEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETV 1940
LE+ + K++ +ETL+ E L+ S+Q+ + ++ +I+Q +L K KE
Sbjct: 1186 LEQEIKIQKQK------QETLQEEITSLQSSVQQYEEKNTKIKQ------LLVKTKKELA 1233
Query: 1941 DKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEME 2000
D + + +Q S K EL+ Q+++ ++QL + + + H E
Sbjct: 1234 DSKQAETDHLILQAS--------LKGELEASQQQVEVYKIQLAEITSEKHKIH------E 1279
Query: 2001 QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELR-RIKESLKMERDQFI 2059
LK E ++ + + L ++ + E V E + + R+ LK ++++ +
Sbjct: 1280 HLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSM 1339
Query: 2060 ATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNR 2119
+ A+ + H + L+ + L +S + EL SE D E N+
Sbjct: 1340 SQAETEGAKQEREHL----EMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK 1395
Query: 2120 -LSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLS 2178
L + KE E +++L N+ + T+ + +L + N+ F
Sbjct: 1396 MLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFR----------D 1445
Query: 2179 YVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLH 2238
V ++EE +++ + + ++E Q +K + + + L++L+ +N DL
Sbjct: 1446 QVRHLQEEHRKTVETLQQQ-LSKMEAQL-FQLKNEPTTRSPVSSQQSLKNLRERRNTDLP 1503
Query: 2239 IEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNT 2278
+ + + + E ++T + +S+ TQ LE+ LN+
Sbjct: 1504 LLD-MHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNS 1542
Score = 185 bits (469), Expect = 6e-46
Identities = 319/1510 (21%), Positives = 651/1510 (43%), Gaps = 221/1510 (14%)
Query: 1246 EHQETIDELR-RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQET 1304
E ++ I+ELR + V+E T II L E + L K +E Q
Sbjct: 50 ELEKEIEELRSKPVTEGTGDIIKA----------------LTERLDALLLEKAETEQQCL 93
Query: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
+ E + + +DS T ++ + +E ++ + KE +NLK A+ K
Sbjct: 94 SLKKENIKMKQEVEDSVT---------KMGDAHKELEQSHINYVKEIENLKNELMAVRSK 144
Query: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTK-IVSEMEQFKPKDSALLRIEIEM 1423
+ + K ++++ L + +Q + + L + + K + E+E+ +P E ++
Sbjct: 145 YSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPG------FEEQI 198
Query: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLET----EEEL 1479
L L K+L + DE +K+ + +LQ ++++ S ++NI + + L+ +EE+
Sbjct: 199 LYLQKQLDATTDE------KKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEV 252
Query: 1480 KVAHCCL----KEQEETIN---ELRVNLSEK-ETEISTIQKQLEAINDKLQ--------- 1522
K C + KE E IN EL+ NL ++ E IQK+ E + L+
Sbjct: 253 KELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQD 312
Query: 1523 NKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQ--- 1579
N+I I +E F ++Q+ V EKV L+ + +++ S L+ + M L +L+
Sbjct: 313 NQICSILLQENTF-VEQV--VNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDA 369
Query: 1580 --------ESQEEIQIMIKE----KEEMKRVQEALQIERDQLK-------ENTKEIVAKM 1620
+E+++ I E KEE V E L+ E L E V +
Sbjct: 370 QHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSL 429
Query: 1621 KESQEKEYQFLKMTAVNETQEK----MCEIEHLKEQFETQK-------LNLENI------ 1663
KE +KE L T +++++++ M EI+ LKEQ E + LN E++
Sbjct: 430 KEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEI 489
Query: 1664 --------------ETENIRLTQI--LHENLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707
E E+++ Q +HE +++R+ E+D L L+ E ++L
Sbjct: 490 LQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLS 549
Query: 1708 NLRETITRDLEK-----QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSN 1762
++ + +LE QE+ + + L + + +L G ++ T E + L++S+
Sbjct: 550 --QQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSH 607
Query: 1763 DALKAQDLKIQEELRIAHMHLKEQQETID---KLRGIVSEKTDKLSNMQKDLENSNAKLQ 1819
+ + K + E R+ K+ ++TI +L V+E T L K+ + ++ KL+
Sbjct: 608 EEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLE 667
Query: 1820 EKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQI-KDQSLTLSKLEIENLNLAQKLH 1878
+ + ++K L +V ++ +++ KKQ+ +D + LS+ E ++ L + +
Sbjct: 668 KLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKE--DVILKEHIT 725
Query: 1879 ENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKE 1938
+ ++++ +++E+DNL ++ LE +Q+++ +T+ +E+ + E K+
Sbjct: 726 QLEKKLQLMVEEQDNLNKL-----LENEQVQKLFVKTQLYGF--LKEMGSEVSEDSEEKD 778
Query: 1939 TVDKLREKISEKTIQISDIQKDLDKSKDE----LQKKIQELQKKEL-------QLLR-VK 1986
V+ L + + E +I++ + +L +DE L+K+I+ LQ++ + LLR +
Sbjct: 779 VVNVL-QAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYE 837
Query: 1987 EDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRR 2046
++ + K++ E++ K+ ++ L M++ + L +EE+ + +
Sbjct: 838 QEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNE 897
Query: 2047 IKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDG--QQHLTESLREKCSRIKELL 2104
++ E + L + RDR+ + + L + S++E +I+ L
Sbjct: 898 KEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE 957
Query: 2105 KRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSM 2164
K E ++ + +++ +KE++ ++ + VK L + + +A+ R +
Sbjct: 958 KECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELE----SLRSEKDQLSASMRDLI 1013
Query: 2165 EFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSR 2224
+ K L ++ + + E N FE D + + ++ + + D +
Sbjct: 1014 QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLA 1073
Query: 2225 ELRDLKLNQNM-DLHIEEI--LKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFD 2281
+ L+ N + ++ I E+ K + E + K + +Q + LEE +
Sbjct: 1074 RIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEE---LQVQ 1130
Query: 2282 IEKLKNGIQKENDRI------CQVNNFFNNRII---AIMNESTEFEERSATISKEWEQDL 2332
++K K +QK + Q N I +M E + ++ EQ++
Sbjct: 1131 LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEI 1190
Query: 2333 KSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHE 2392
K K+K E L + +L++S+ + N ++ QL + +EL +S
Sbjct: 1191 KIQKQKQETLQEEITSLQSSVQQYEEKN------------TKIKQLLVKTKKELADSKQA 1238
Query: 2393 AKESAMHKES---KIIKMQKELEVTNDIIAKLQA---KVHESNK-CLEKTKETIQVLQDK 2445
+ + + S ++ Q+++EV +A++ + K+HE K E+ + T+ Q +
Sbjct: 1239 ETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQR 1298
Query: 2446 VAL------GAKPYK----EEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEV 2495
V AK + E E K+++ + L++ KN + E K E+ + +
Sbjct: 1299 VTALQEECRAAKAEQATVTSEFESYKVRVHNV-LKQQKNKSMSQAETEGAKQEREHLEML 1357
Query: 2496 IRLLRENLRRSQQAQDTSVI------SEH-TDPQPSNKPLTCGGGSGIVQNTKALILKSE 2548
I L+ L+ SQ +V SEH T + NK L K ++SE
Sbjct: 1358 IDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSE 1417
Query: 2549 HIRLEKE----ISKLKQQNEQLIKQKNELLSNNQHLSNE----VKTWKERTLKREAHK-Q 2599
++ ++ E +S+L QNE L +N +HL E V+T +++ K EA Q
Sbjct: 1418 NMMMKSEHTQTVSQLTSQNEVL---RNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
Query: 2600 VTCENSPKSP 2609
+ E + +SP
Sbjct: 1475 LKNEPTTRSP 1484
Score = 172 bits (435), Expect = 5e-42
Identities = 287/1319 (21%), Positives = 559/1319 (42%), Gaps = 170/1319 (12%)
Query: 1374 ETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQES 1433
ETL K + ++Q + +++ + T++ E+E+ + K G ++
Sbjct: 23 ETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTE--------GTGDIIKAL 74
Query: 1434 HDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC-CLKEQEET 1492
+ + ++ EK + ++ L+ E+ ++K+ +++ V K + +EL+ +H +KE E
Sbjct: 75 TERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENL 134
Query: 1493 INELRVNLSEKETEISTIQKQLE-AINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELK 1551
NEL S+ + + +QKQLE A+N +L+ Q ++ + N+K++ E EK+
Sbjct: 135 KNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRP-- 192
Query: 1552 QFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKE 1611
E ++L L +L + +E +KE + ++Q ++ ++
Sbjct: 193 --------------GFEEQILYLQKQLDATTDE------KKETVTQLQNIIEANSQHYQK 232
Query: 1612 NTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLT 1671
N + ++E LK E +E MC+IE ++ E + L ++ ++
Sbjct: 233 NINSL--------QEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQC 284
Query: 1672 QILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLK 1731
+ +N+++ E ++LR + L+E + E++K HL+
Sbjct: 285 EASEKNIQKKYEC--ELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVK----HLE 338
Query: 1732 EHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETID 1791
+ + ++ I+ ++ ++N++ LE +K + +E+L L +E
Sbjct: 339 DTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEE-- 396
Query: 1792 KLRGIVSEKT-DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850
+G V EK +L+ + K + + ++Q LK + I+ ++NET SE E
Sbjct: 397 --QGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEIS---ELNETFLSDSEKE 451
Query: 1851 QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER----- 1905
+L + Q L K + ENL +E + + ++LR + E L+ E
Sbjct: 452 KLTLMFEIQGL---KEQCENLQ---------QEKQEAILNYESLREIMEILQTELGESAG 499
Query: 1906 --DQLKESLQETKARDL-EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD 1962
Q ES+++ +A D+ E+QQ+L+TA ETV++L+ + +EK + ++ +L+
Sbjct: 500 KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGE-NEKLLSQQELVPELE 558
Query: 1963 KSKDELQKK----IQELQKKELQLLRVKEDVN-MSHKKINEMEQLKKQFEAQNLSMQSVR 2017
+ LQ+K + L +++ L ++ +N ++ +K + + +LK E
Sbjct: 559 NTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHE---------E 609
Query: 2018 MDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKP 2077
MDNF KK I + K+ ++ + L+ + ++ L E + QN Q K
Sbjct: 610 MDNFH--KKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQ-KL 666
Query: 2078 EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE-----KEIEFQK 2132
EK ++ + L+E + +K L + +++ + L+R DLE KE K
Sbjct: 667 EKLMVQ--MKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSR---DLEVFLSQKEDVILK 721
Query: 2133 ELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHE-SI 2191
E +++ L L + ++ KL Q ++KL +KE E S
Sbjct: 722 EHITQLEKKLQLMVEEQDNLNKLLENEQ---------VQKLFVKTQLYGFLKEMGSEVSE 772
Query: 2192 NKFEMDFIDEVEKQKELLIKIQHLQQDCDVP-SRELRDLKLNQNMDLHIEEILKDFSESE 2250
+ E D ++ ++ E L KI ++ C++ R+ + L+L + + EE + E +
Sbjct: 773 DSEEKDVVNVLQAVGESLAKIN--EEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELK 830
Query: 2251 FPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQK---ENDRIC-QVNNFFNNR 2306
E ++VL RKE+ + E + D+ ++KN +K EN + QV
Sbjct: 831 SLLRDYEQEKVLL-RKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE----- 884
Query: 2307 IIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT--LKTSLASGAQVNPTTQ 2364
+ ++S E+ KE E +LK L E+ E + + LK SLA V
Sbjct: 885 VSQTCSKSEIHNEKEKCFIKEHE-NLKPLLEQKELRDRRAELILLKDSLAKSPSV----- 938
Query: 2365 DNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAK 2424
KN ++S + EKI LE E +E + +K +KEL+ + K
Sbjct: 939 --KNDPLSS--VKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSR----KETQT 990
Query: 2425 VHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISA 2484
V E + L K+ + + GA+ YK + + + + ++D+EK + A FE I
Sbjct: 991 VKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK-ERANNFEHRI-- 1047
Query: 2485 TKATVEYQKEVIRLLRENLRRSQQA-QDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKAL 2543
+++ R LR + + + D + + SN L + L
Sbjct: 1048 --------EDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLL---------EVQIL 1090
Query: 2544 ILKSEHIRLEKEISKLKQQNEQLIKQK----NELLSNNQHLSNE----VKTWKERTLKRE 2595
++ ++KE+ K Q EQ IK+ NEL L E KT +E L ++
Sbjct: 1091 EVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKK 1150
Query: 2596 AHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPS 2654
+Q T N + +++T K +L+ + + K SL S
Sbjct: 1151 DAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQS 1209
Score = 143 bits (360), Expect = 3e-33
Identities = 209/1059 (19%), Positives = 447/1059 (42%), Gaps = 147/1059 (13%)
Query: 335 VNEVSTD-EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEK 393
VNE++ E LK + L+K + ++ + + + + ++ L EE + L + +
Sbjct: 645 VNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQL 704
Query: 394 IENLTRMLVTSSSLTLQQELKAKRKRRVTWC--LGKINKMKNSNYADQFNIPTNI----- 446
+L L + L++ + K+ +NK+ + + + T +
Sbjct: 705 SRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK 764
Query: 447 -------TTKTHKLSINLLREIDESVCSESDVFSNTLDTLSE--IEWNPATKLLNQENIE 497
K +N+L+ + ES+ ++ N E +E K L +E++
Sbjct: 765 EMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVV 824
Query: 498 S--ELNSLRADYDN----LVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKT------- 544
EL SL DY+ L + E++++EKE ++ L E + +E LE +
Sbjct: 825 QCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE 884
Query: 545 ----------KKDQEMQLIHEISNLKNLVKHAEVYNQD-----LENELSSKVELLREKED 589
++E I E NLK L++ E+ ++ L++ L+ + +
Sbjct: 885 VSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS 944
Query: 590 QIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENL 649
+K+L+E K+EN++ + K+ ++ + + VA+ AK+E R E
Sbjct: 945 SVKELEE-----KIENLEKEC----------KEKEEKINKIKLVAVKAKKELDSSRKETQ 989
Query: 650 ELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVP 709
+KE+++ L + Q+ ++ E+ K + ++ EK+ + V
Sbjct: 990 TVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQL-------------DVE 1036
Query: 710 KDLLCNLELEGKITDLQKELNKEVEENEALR-EEVILLSELKSLPSEVERLRKEIQDKSE 768
K+ N E +I DL ++L + E + + LL+ +++L S + L +I +
Sbjct: 1037 KERANN--FEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQR 1094
Query: 769 ELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMD 828
++ E L +E + KE +++ + + ++ Q K + Q + + D
Sbjct: 1095 AKAMVDKE---LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKD 1151
Query: 829 FEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNE 888
+Q MN EI + ++ + L +L+ K ++++ +E++ + +
Sbjct: 1152 AQQ--------TTLMNMEIAD-------YERLMKELNQKLTNKNNKIEDLEQEIKIQKQK 1196
Query: 889 MEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESL--QIERD 946
E L+E++ + S++Q E + T I + L +T +E+ Q + D LQ SL ++E
Sbjct: 1197 QETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEAS 1256
Query: 947 QLKSDIHDTVNMNIDTQEQL--RNALESLKQHQETINTLKSKIS--EEVSRNLHMEENTG 1002
Q + +++ I +++ + S +QHQ T++ + +++ +E R E+ T
Sbjct: 1257 QQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATV 1316
Query: 1003 ETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN----EIIEQQRKIFSLIQEKNELQ-- 1056
++ E + V KQ +Q T K E++ Q KI L +N LQ
Sbjct: 1317 TSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKI-KLQDSQNNLQIN 1375
Query: 1057 -QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKK---E 1112
L+++ +E + L + ++ T+ + ELR ++ + ++ E + + +
Sbjct: 1376 VSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQ 1435
Query: 1113 GELSRTC--DRLAEVEEK----LKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN- 1165
E+ R D++ ++E+ ++ QQL + + QL ++ E + + ++ ++LKN
Sbjct: 1436 NEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPT-TRSPVSSQQSLKNL 1494
Query: 1166 -ELKNKELTLEHMETERLELAQKL-NENYEEVKSITKERKVLKELQKSFETE-------- 1215
E +N +L L M T E + + + E V S + + L++L S ET+
Sbjct: 1495 RERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHA 1554
Query: 1216 -----------------RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSV 1258
DHL G +RE EAT E++K+ ++ + + + +
Sbjct: 1555 EFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAA 1614
Query: 1259 S-EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVK 1296
+ E ++ K ++ + +PV++ +L P K
Sbjct: 1615 NLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEK 1653
Score = 52.0 bits (123), Expect = 8e-06
Identities = 121/621 (19%), Positives = 253/621 (40%), Gaps = 80/621 (12%)
Query: 314 DETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEK 373
D+ L A + K ++ VNE+ + L++ +K++ ++LE V + + +
Sbjct: 1100 DKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN 1159
Query: 374 DQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKN 433
++A + + L K N+K+ N + L+QE+K +++++ T +I +++
Sbjct: 1160 MEIA----DYERLMKELNQKLTNKNNKIE-----DLEQEIKIQKQKQET-LQEEITSLQS 1209
Query: 434 SNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQ 493
S Q+ TK +L + +E+ +S +E+D E+E +Q
Sbjct: 1210 S--VQQYE---EKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELE-------ASQ 1257
Query: 494 ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLI 553
+ +E L +E L+T E+ + L E + K ++ +
Sbjct: 1258 QQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVT 1317
Query: 554 HEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYI-----DSQKLENIKM 608
E + K V H + Q ++ ++ E +++ + ++ L + + DSQ I +
Sbjct: 1318 SEFESYKVRV-HNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINV 1376
Query: 609 DLSYSLESIEDPKQMKQTLFDAETVALDA--KRESAFLRSENLELK----EKMKELATTY 662
+L+S D + ETV+ +A + + ++SEN+ +K + + +L +
Sbjct: 1377 SELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQN 1436
Query: 663 KQMENDI--QLYQSQLEAKKKMQV------DLEKELQSAFNEITKLTSLIDGKVPKDLLC 714
+ + N Q+ Q E +K ++ +E +L NE T + + + K+L
Sbjct: 1437 EVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRE 1496
Query: 715 NLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIIT 774
+ + D+ +E E E E + S + +E+L +
Sbjct: 1497 RRNTDLPLLDMHTVTREEGEGMETTDTESV--SSASTYTQSLEQL-------------LN 1541
Query: 775 SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834
S + KL + H E + L++++ T KS D + L + E
Sbjct: 1542 SPETKLEPPLWHAEFTKEELVQKLSSTT----------KSAD----HLNGLLRETEATNA 1587
Query: 835 MVLEENERMNQEIVNL--SKEAQKFDSSLGALKTELSYKTQELQEKTREVQERL----NE 888
+++E+ + + EI L ++E +K ++L LK L Q + K +ERL N
Sbjct: 1588 ILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL---LQFIFLKPGSERERLLPVINT 1644
Query: 889 MEQLKEQLENRDSTLQTVERE 909
M QL + + + + + E E
Sbjct: 1645 MLQLSPEEKGKLAAVAQGEEE 1665
>gi|46852172 kinesin family member 13B [Homo sapiens]
Length = 1826
Score = 246 bits (627), Expect = 3e-64
Identities = 161/409 (39%), Positives = 233/409 (56%), Gaps = 34/409 (8%)
Query: 4 EGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGS----------KSFNFDRVF 53
+ V V VR+RP+N RE L V + ++ V+ + K F +D F
Sbjct: 3 DSKVKVAVRIRPMNRRETDLHTKCVVDVDANKVILNPVNTNLSKGDARGQPKVFAYDHCF 62
Query: 54 HG-NETTKN-------VYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGV 105
+E+ K V++ + I+ +A GYN IFAYGQT SGK+YTMMG+ D G+
Sbjct: 63 WSMDESVKEKYAGQDIVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGL 122
Query: 106 IPRAIHDIFQKIKKFPDRE--FLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVY 163
IPR +F++ +K + E F + VSYMEIYNE + DLL + L +RE Y
Sbjct: 123 IPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPY 182
Query: 164 VADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCE 223
V L++ V + + +++G KSR T MN+ SSRSH +F++ L S
Sbjct: 183 VDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTS 242
Query: 224 GSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVG----G 279
G KV L+LVDLAGSERA +TGAAG RLKEG NIN+SL LG VI L+D G
Sbjct: 243 GE-KVGKLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTLGLVISALADQSAGKNKNK 301
Query: 280 FINYRDSKLTRILQNSLGGNAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNE 337
F+ YRDS LT +L++SLGGN+KT ++ T++P ++DETL+ L++A AK++ N VNE
Sbjct: 302 FVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVNE 361
Query: 338 VSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLL 386
+ +++ R+E+ L++QL T+A+AM+ +L LEE + L
Sbjct: 362 -DPNARIIRDLREEVEKLREQL------TKAEAMKSPELKDRLEESEKL 403
Score = 37.4 bits (85), Expect = 0.20
Identities = 74/388 (19%), Positives = 157/388 (40%), Gaps = 39/388 (10%)
Query: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN 1165
NHA+ E +R L E EKL+E+ + + + L ++ + E +K I E+
Sbjct: 355 NHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMKSPEL--KDRLEESEKLIQEMTVTWE 412
Query: 1166 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE 1225
E K E + ER + + L + + + K + + L Y++E
Sbjct: 413 EKLRKT---EEIAQERQKQLESLGISLQSSGIKVGDDKCFLVNLNADPALNELLVYYLKE 469
Query: 1226 IEATGLQTKEELKIAHIHLKEHQETID-----ELRRSVSEKTAQIINTQDLEKSHTKLQE 1280
G +++++ + + ID ++ + + T +N + S +L
Sbjct: 470 HTLIGSANSQDIQLCGMGILPEHCIIDITSEGQVMLTPQKNTRTFVNGSSVS-SPIQLHH 528
Query: 1281 EIPVL----HEEQELLPNVKEVSETQETMNELELLTEQSTTK---DSTTLARIEMERLRL 1333
+L H + LP K+ +E ++ + + E S+ + D + + + E +
Sbjct: 529 GDRILWGNNHFFRLNLPKKKKKAEREDEDQDPSMKNENSSEQLDVDGDSSSEVSSE-VNF 587
Query: 1334 NEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMK 1393
N ++ + + +K+L D +++I +LE +H++ K E + E + +Q +
Sbjct: 588 NYEYAQMEVTMKALGSN-DPMQSILNSLEQQHEEEKRSALERQRLMYEHELEQLRRRLSP 646
Query: 1394 EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEV 1453
EK N M++F +RL++ +E + A + L RL+E
Sbjct: 647 EKQN-----CRSMDRF----------SFHSPSAQQRLRQWAEERE--ATLNNSLMRLREQ 689
Query: 1454 LQSESDQLKENIKEIVAKHLETEEELKV 1481
+ + ++E +A+ L+ E KV
Sbjct: 690 IVKANLLVRE--ANYIAEELDKRTEYKV 715
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 244 bits (623), Expect = 8e-64
Identities = 288/1341 (21%), Positives = 603/1341 (44%), Gaps = 147/1341 (10%)
Query: 858 DSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT--- 914
+S+L + +++ QE+Q+ ++E E+LK++LE Q + L+T
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 915 ---EKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
+ L+Q LEE +T E ++KQ+++ + + QL ++I D + D + LR A E
Sbjct: 135 AELQSLEQQLEEAQT---ENFNIKQMKDLFEQKAAQLATEIAD-IKSKYDEERSLREAAE 190
Query: 972 SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA 1031
++++EE+++ + + + K E Q+ GI+ L+ + Q T
Sbjct: 191 Q----------KVTRLTEELNKEATVIQ---DLKTELLQR-PGIEDVAVLKKELVQVQT- 235
Query: 1032 DVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDL---KENIEMTIENQEELR 1088
+ DN +E++R+ L E +LQ S A QL+++L + + + ++ ++L+
Sbjct: 236 -LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLK 294
Query: 1089 LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQE 1148
+EL ++ + + + + +KKE + ++ +EEK E+S + Q L
Sbjct: 295 SSVNELTQKNQTLTE---NLLKKEQDYTK-------LEEKHNEESVSKKNIQATLHQKDL 344
Query: 1149 EMSEMQKKINEIENLKNELKNKELTLEHME-TERLELAQKLNENYEEVKSITKERKV-LK 1206
+ ++Q +++ E + + H+E +E+ E QKL E EV++ + K K
Sbjct: 345 DCQQLQSRLSASETSLHRI--------HVELSEKGEATQKLKEELSEVETKYQHLKAEFK 396
Query: 1207 ELQKSFETERDH---LRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTA 1263
+LQ+ E + H L+ I ++ + L+T+ +L AH LKE ++ E ++ A
Sbjct: 397 QLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVA 456
Query: 1264 QI------INTQDLEK--SHTKLQEEIPVL---HEEQELLPN----------------VK 1296
+ + Q EK + T+LQ ++ H+EQ+ L ++
Sbjct: 457 DLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516
Query: 1297 EVSETQETMNELELLTEQSTTKDSTTLARIEMERL---------------RLNEKFQESQ 1341
++ + + + LE L ++S K++ +L E E L +L EK Q
Sbjct: 517 QIGDKDQKIQNLEALLQKS--KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
Query: 1342 EEIKSLT-KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLN-MKEKDNET 1399
E++ LT K ++ ++ K+A E HDQ++E + L Q+ E S+N + + NE+
Sbjct: 575 EQVTQLTEKLKNQSESHKQAQENLHDQVQEQ-KAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 1400 TKIVSEME-QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSES 1458
+ VS+++ Q K K LL E LQ D ++ ++K Q E
Sbjct: 634 KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK----------QQEL 683
Query: 1459 DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN 1518
+++ + ++ AK + +E LKE +E L E E +I ++ +
Sbjct: 684 NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK 743
Query: 1519 DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRL 1578
+ +Q++ +++ Q N E +L+ KE + LQ + + +L
Sbjct: 744 ASKEQALQDL-QQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM-KESQEKEYQFLKMTAVN 1637
+ +EE QI+ K++ + + + +I+ ++L + V ++ K EKE +++ V
Sbjct: 803 TKQEEEKQIL---KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 1638 ETQEKMCE-IEHLKEQF--ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSV 1694
+ K+ + +++ K +F E QK ++ E ++ H+ +M + KE+ +L+
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK-TCKELKHQLQVQMENTLKEQKELKKS 918
Query: 1695 EETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNM 1754
E K QLK L + ++ Q LK ++ Q I++L+ +K +I +
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
Query: 1755 QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814
Q +L+ + + K+Q++L A L ++E I L+ + + +Q D
Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038
Query: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874
++L Q+LK+ E +L ++D+ + ++ +L +++K T LE ++
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKAT---LEQDSAKKE 1095
Query: 1875 QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARD----LEIQQELKTAR 1930
Q+L E + ++ + KE+ E+ L E+ +L E ++E K R ++ +ELK+ +
Sbjct: 1096 QQLQERCKALQDIQKEKS---LKEKELVNEKSKLAE-IEEIKCRQEKEITKLNEELKSHK 1151
Query: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVN 1990
+ S + + ++ + ++ +++ + D K+ E +K+ Q++ K +++ KE+
Sbjct: 1152 LESIKEITNLKDAKQLLIQQKLELQG-KADSLKAAVEQEKRNQQILKDQVK----KEEEE 1206
Query: 1991 MSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKES 2050
+ + I + +L + + + + M+ + +LT ++ E + V KE +R
Sbjct: 1207 LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSE 1266
Query: 2051 LKMERDQF---IATLREMIARDRQNHQVKPEKRLLSDGQ--------QHLTESLREKCSR 2099
L+ + D IA L + ++ + E+ L +G+ L L +
Sbjct: 1267 LEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAA 1326
Query: 2100 IKELLKRYSEMD-DHYECLNR 2119
++EL + + H + LNR
Sbjct: 1327 VQELGRENQSLQIKHTQALNR 1347
Score = 240 bits (612), Expect = 2e-62
Identities = 320/1391 (23%), Positives = 623/1391 (44%), Gaps = 201/1391 (14%)
Query: 747 SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKE-SRVQGLLEEIGKTKDDL 805
S L +V LR+E+QD L +++K +SE + KE + QGL ++ K +
Sbjct: 76 SNLALKRDDVTLLRQEVQDLQASL-----KEEKWYSEELKKELEKYQGLQQQEAKPDGLV 130
Query: 806 ATTQSNYKSTDQEFQ-------NFKTLHMDFEQKYKMVLEE--------------NERMN 844
+ + +S +Q+ + N K + FEQK + E E
Sbjct: 131 TDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAE 190
Query: 845 QEIVNLSKEAQKFDSSLGALKTELSYK-----TQELQEKTREVQ--------ERLNEMEQ 891
Q++ L++E K + + LKTEL + L+++ +VQ ER E E+
Sbjct: 191 QKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEK 250
Query: 892 LKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSD 951
LK++ + S + E + + +L + +EV QE LK L +
Sbjct: 251 LKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL--------TQ 302
Query: 952 IHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQK 1011
+ T+ N+ +EQ LE K ++E+++ + + LH ++ + + Q +
Sbjct: 303 KNQTLTENLLKKEQDYTKLEE-KHNEESVS------KKNIQATLHQKDLDCQ---QLQSR 352
Query: 1012 MVGID---KKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQ 1068
+ + + +E T +K+ E+ E + K L E +LQQ E Q
Sbjct: 353 LSASETSLHRIHVELSEKGEATQKLKE-ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQ 411
Query: 1069 LKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEK 1128
L++++ + +E + +L LK+Q+++ +++ + KE +++ +L+ +EE+
Sbjct: 412 LQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEK---LMDKEQQVADLQLKLSRLEEQ 468
Query: 1129 LKEKSQQLQEKQQQLLNVQEEMSEMQ-----------KKINEIENLKNELKNKELTLEHM 1177
LKEK E Q QL +++ E Q + N++E + ++ +K+ ++++
Sbjct: 469 LKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNL 528
Query: 1178 ET------ERLELAQKLNEN-YEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230
E E + L +K E+ Y ++++ E VL +LQ+ T ++ + +++
Sbjct: 529 EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 588
Query: 1231 LQTKEELKIAH-------IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIP 1283
K+ + H HL+ Q+ + L SV+E +Q L +S K+ +
Sbjct: 589 ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ------LNESKEKVSQLDI 642
Query: 1284 VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD-STTLARIEMERLRLNEKFQESQE 1342
+ + ELL + + Q + L T Q+ +D L +I + ++ K Q+ QE
Sbjct: 643 QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
Query: 1343 EIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKI 1402
L K +LE K ++L+ I++ A E ++ +EQ+L
Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL------------ 750
Query: 1403 VSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQL- 1461
+++Q + ++ L E+ LSK+L+ E + V+ + DLQ+ E L+S +L
Sbjct: 751 -QDLQQQRQLNTDL---ELRATELSKQLEM---EKEIVSSTRLDLQKKSEALESIKQKLT 803
Query: 1462 -KENIKEIVAKHLET-EEELKVAHCCLKEQ-EETINELRVNLSEKE---TEISTIQKQLE 1515
+E K+I+ + ET +E K+ H L + + T+ EL+ EKE TE+ST++ +L
Sbjct: 804 KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863
Query: 1516 AINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELT 1575
++D L+N E +EKE Q I ++++ ELK +++
Sbjct: 864 KVSDSLKNSKSE-FEKENQKGKAAILDLEKTCKELK----------------HQLQVQME 906
Query: 1576 NRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA 1635
N L+E +E + + KEKE +++ L ++QL + + KE Q+ + ++
Sbjct: 907 NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
Query: 1636 VNETQEKMCEIEHLKEQFE---TQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLR 1692
+E ++K +IE L+ + + QK LEN + +LTQ E E ++ +++
Sbjct: 967 SSEQKKK--QIEALQGELKIAVLQKTELENKLQQ--QLTQAAQELAAEKEKISVLQNNYE 1022
Query: 1693 SVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEIS 1752
+ET K QL+ + + L +++LK V L QE + R N+I
Sbjct: 1023 KSQETFK----QLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR-------NQIG 1071
Query: 1753 NMQK---DLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809
N K +L+ + L+ K +++L QE L+ I EK+ K +K
Sbjct: 1072 NQNKLIQELKTAKATLEQDSAKKEQQL----------QERCKALQDIQKEKSLK----EK 1117
Query: 1810 DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK--QIKDQSLTLSKLE 1867
+L N +KL E I+E+K + + IT +NE + K ++E +K+ +KD L + +
Sbjct: 1118 ELVNEKSKLAE-IEEIKCRQEKEIT---KLNE-ELKSHKLESIKEITNLKDAKQLLIQQK 1172
Query: 1868 IENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELK 1927
+E A L +E+ E+ N + +++ +K E ++LK+ E +A+ + E+K
Sbjct: 1173 LELQGKADSLKAAVEQ------EKRNQQILKDQVKKEEEELKKEFIEKEAK---LHSEIK 1223
Query: 1928 TARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSK---DELQKKIQELQKKELQLLR 1984
+ K+H+E KL +I+ + ++K+ S+ EL+K+ +L + E+ +L
Sbjct: 1224 EKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL-RGEIAVLE 1282
Query: 1985 VKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDEL 2044
N ++ LK + E + L + + +L +KL + ++ + +E L
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVL-----ELQRKLDNTTAAVQELGRENQSL 1337
Query: 2045 RRIKESLKMER 2055
+IK + + R
Sbjct: 1338 -QIKHTQALNR 1347
Score = 232 bits (591), Expect = 4e-60
Identities = 326/1467 (22%), Positives = 639/1467 (43%), Gaps = 269/1467 (18%)
Query: 545 KKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLE 604
K+D L E+ +L+ +K + Y+++L+ EL K + L+++E K +
Sbjct: 81 KRDDVTLLRQEVQDLQASLKEEKWYSEELKKELE-KYQGLQQQE------------AKPD 127
Query: 605 NIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQ 664
+ D S L+S+E Q L +A+T EN +K+ Q
Sbjct: 128 GLVTDSSAELQSLE------QQLEEAQT--------------ENFNIKQMKDLFEQKAAQ 167
Query: 665 MENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITD 724
+ +I A K + D E+ L+ A E K+T
Sbjct: 168 LATEI--------ADIKSKYDEERSLREA------------------------AEQKVTR 195
Query: 725 LQKELNKEVEENEALREEV----------ILLSELKSLPSEVERLRKEIQDKSEELHIIT 774
L +ELNKE + L+ E+ +L EL + + ++ + E + +SE+L
Sbjct: 196 LTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL---K 252
Query: 775 SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834
E KL S+ E+ + L E+ K ++A QE Q K+ + QK +
Sbjct: 253 DECKKLQSQYASSEATISQLRSELAKGPQEVAVYV-------QELQKLKSSVNELTQKNQ 305
Query: 835 MVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE 894
+ E NL K+ Q + T+L K E + +Q L++ + +
Sbjct: 306 TLTE----------NLLKKEQDY--------TKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
Query: 895 QLENRDSTLQT------VE-REKTLITEKLQQTLEEVKTLTQE-KDDLKQLQESLQIERD 946
QL++R S +T VE EK T+KL++ L EV+T Q K + KQLQ+ + +
Sbjct: 348 QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407
Query: 947 ---QLKSDIHDTVNMNIDTQEQLRNALESLKQHQE------------------TINTLKS 985
QL+S+I+ + ++T+ QL A LK+ ++ ++ L+
Sbjct: 408 HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467
Query: 986 KISEEVSRNLHMEENTGETKDEFQQ-----------------------KMVGIDKKQDLE 1022
++ E+V+ + ++ +TK + Q+ + +G DK Q ++
Sbjct: 468 QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG-DKDQKIQ 526
Query: 1023 AKNTQTLTADVKDN-EIIEQQRK-IFSLIQE-------KNELQQMLESVIAEKEQLKTDL 1073
N + L K+N ++E++R+ +++ IQ N+LQ+ ++ + QL L
Sbjct: 527 --NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL 584
Query: 1074 KENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKS 1133
K E + QE L D++++Q+ + ++ + E ++ +L E +EK+ +
Sbjct: 585 KNQSESHKQAQENLH---DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLD 641
Query: 1134 QQLQEKQQQLLNVQEEMSEMQKKI-NEIENLKNELKNKELTLEHMETERLELAQKLNENY 1192
Q++ K + LL+ + + + + N ++ +N L++K+ L + T+ ++ KL +
Sbjct: 642 IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ 701
Query: 1193 EEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252
E + K KE S E + + L G I+++EA L+ K + A L++ ++
Sbjct: 702 EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNT 761
Query: 1253 ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLT 1312
+L +E + Q+ +++ S T+L L ++ E L ++K+ QE E ++L
Sbjct: 762 DLELRATELSKQLEMEKEIVSS-TRLD-----LQKKSEALESIKQKLTKQE--EEKQILK 813
Query: 1313 EQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHI 1372
+ T T +++ LN + Q + E++ + E++ L T +
Sbjct: 814 QDFETLSQET----KIQHEELNNRIQTTVTELQKVKMEKEALMTELST-----------V 858
Query: 1373 RETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE 1432
++ L+K+ +S + EK+N+ K +A+L +E L +LQ
Sbjct: 859 KDKLSKVSDSLKNSKSEF---EKENQKGK------------AAILDLEKTCKELKHQLQV 903
Query: 1433 SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEET 1492
+M++ KE+ +L++ E + S QLK + + +E+L A LK+ E+
Sbjct: 904 ---QMENTLKEQKELKKSLEKEKEASHQLKLELNSM-------QEQLIQAQNTLKQNEKE 953
Query: 1493 INELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQ 1552
+L+ N++E + +KQ+EA+ +L+ + + E E +++Q+++ + Q
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE--------NKLQQQLTQAAQ 1005
Query: 1553 FKEHRKAKDSALQSIESKMLELTNRLQ-ESQEEIQIMIKEKEEMKRVQEALQIERDQLKE 1611
K K S LQ+ K E +LQ + ++ ++++K V+E L + ++ L
Sbjct: 1006 ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065
Query: 1612 NTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLT 1671
N +I +Q K Q LK Q+ + + L+E+ + L++I+ E
Sbjct: 1066 NRNQI-----GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA----LQDIQKE----- 1111
Query: 1672 QILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLK 1731
++L+E + + E+ L +EE + ++ + E + LE +E+ +LK
Sbjct: 1112 ----KSLKE-KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI----TNLK 1162
Query: 1732 EHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETID 1791
+ ++ + + + + K + + + + + LK Q K +EEL+ +E I+
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELK---------KEFIE 1213
Query: 1792 KLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQ 1851
K + SE +K M+K EN AKL +I L N L T+KK+ +Q++VSE+E
Sbjct: 1214 KEAKLHSEIKEKEVGMKKHEEN-EAKLTMQITALNEN---LGTVKKEWQSSQRRVSELE- 1268
Query: 1852 LKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKES 1911
KQ D ++ LE N + LE E + L+ L+ + D +
Sbjct: 1269 --KQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAA 1326
Query: 1912 LQETKARDLEIQQELKTARMLSKEHKE 1938
+QE + +Q +K + L+++ E
Sbjct: 1327 VQELGRENQSLQ--IKHTQALNRKWAE 1351
Score = 214 bits (545), Expect = 9e-55
Identities = 281/1376 (20%), Positives = 602/1376 (43%), Gaps = 156/1376 (11%)
Query: 922 EEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETIN 981
++V L QE DL+ + + ++LK ++ + QE + L + +
Sbjct: 83 DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKY--QGLQQQEAKPDGL--VTDSSAELQ 138
Query: 982 TLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI-----DKKQDLEAKNTQTLTADVKDN 1036
+L+ ++ E + N ++++ KD F+QK + D K + + + A+ K
Sbjct: 139 SLEQQLEEAQTENFNIKQ----MKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 1037 EIIEQQRKIFSLIQE-KNELQQM--LESVIAEKEQLKTDLKENIEMTIENQEELRLLGDE 1093
+ E+ K ++IQ+ K EL Q +E V K++L MT+E + E L DE
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 1094 LKKQQE-------IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNV 1146
KK Q ++Q ++ K E++ L +++ + E +Q+ Q + LL
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 1147 QEEMSEMQKKINEI----ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKER 1202
+++ +++++K NE +N++ L K+L + +++ L+ + E+ +
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
Query: 1203 KVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKT 1262
+ LKE ET+ HL+ ++++ Q +EE
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQ----QQREEK------------------------- 405
Query: 1263 AQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTT 1322
E+ +LQ EI LH + LL +++ E + E L+ +
Sbjct: 406 ---------EQHGLQLQSEINQLHSK--LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ 454
Query: 1323 LARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQES 1382
+A ++++ RL E+ +E L + D K +H + + + T AK++E+
Sbjct: 455 VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ-------QHQEQQALQQSTTAKLREA 507
Query: 1383 QSKQEQSL-NMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVA 1441
Q+ EQ L + +KD + + + +++ K S L E E L ++Q E +
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL---EKEREDLYAKIQAGEGETAVL- 563
Query: 1442 KEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLS 1501
+ LQ LQ + QL E +K H + +E L H ++EQ+ + + +
Sbjct: 564 ---NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENL---HDQVQEQKAHLRAAQDRVL 617
Query: 1502 EKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV---NELKQFKEHRK 1558
ET ++ + QL +K+ +I K E + ++ ++ N L + +
Sbjct: 618 SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQ 677
Query: 1559 AKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVA 1618
K L I +++ ++T +LQ+ QE + +E K +L+ + ++L+ K++ A
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737
Query: 1619 ---KMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILH 1675
++K S+E+ Q L+ T ++ E L +Q E +K + + + + ++ L
Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATE-LSKQLEMEKEIVSSTRLDLQKKSEALE 796
Query: 1676 ENLEEMRSVTKERDDLRSVEETL----KVERDQLKENLRETITRDLEKQEELKIVHMHLK 1731
+++ +E+ L+ ETL K++ ++L ++ T+T EL+ V M +
Sbjct: 797 SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT-------ELQKVKMEKE 849
Query: 1732 EHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETID 1791
+ ++ +S+ ++ + N + + E N KA L +++ + L+ Q E
Sbjct: 850 ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 1792 K----LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNE----TQ 1843
K L+ + ++ + ++ +L + +L + LK NE + L+ ++NE ++
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969
Query: 1844 KKVSEMEQLKKQIKDQSLTLSKLEIEN---LNLAQKLHENLEEMKSVMKERDNLRRVEET 1900
+K ++E L+ ++K L K E+EN L Q E E + + ++N + +ET
Sbjct: 970 QKKKQIEALQGELK--IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
Query: 1901 LKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKD 1960
K QL+ ++ L +Q+LK+ +E + R +I + I +++
Sbjct: 1028 FK----QLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTA 1083
Query: 1961 LDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKK-INEMEQLKKQFEAQNLSMQSVRMD 2019
+ + KK Q+LQ++ L ++++ ++ K+ +NE +L + E + + +
Sbjct: 1084 KATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL 1143
Query: 2020 NFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEK 2079
N +L ES++EI + + L + K L+ + D +L+ + ++++N Q+
Sbjct: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD----SLKAAVEQEKRNQQI---- 1195
Query: 2080 RLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVK 2139
L D + E L+++ I++ K +SE+ EKE+ +K K
Sbjct: 1196 --LKDQVKKEEEELKKEF--IEKEAKLHSEIK-------------EKEVGMKKHEENEAK 1238
Query: 2140 ANLSLPYLQTK--HIEKLFTANQRCSMEFHRIMKKLK---YVLSYVTKIKEEQHESINKF 2194
+ + L ++K + ++QR E + L+ VL + +++ ++ +
Sbjct: 1239 LTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLER 1298
Query: 2195 EMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDL-KLNQNMDL-HIEEILKDFSE 2248
+ E+EK L K+ LQ+ D + +++L + NQ++ + H + + + ++E
Sbjct: 1299 CLKGEGEIEK---LQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAE 1351
Score = 207 bits (527), Expect = 1e-52
Identities = 274/1363 (20%), Positives = 606/1363 (44%), Gaps = 176/1363 (12%)
Query: 1060 ESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTC 1119
ES +A K T L++ ++ + +E + +ELKK+ E + K +G ++ +
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 1120 DRLAEVEEKLKE-KSQQLQEKQ------QQLLNVQEEMSEMQKKINE-----------IE 1161
L +E++L+E +++ KQ Q+ + E+++++ K +E +
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDH--- 1218
L EL + ++ ++TE L+ E+V + KE ++ L + ER+
Sbjct: 195 RLTEELNKEATVIQDLKTELLQ-----RPGIEDVAVLKKELVQVQTLMDNMTLERERESE 249
Query: 1219 --------LRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ----II 1266
L+ EAT Q + EL + + + + +L+ SV+E T +
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE 309
Query: 1267 NTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTK---DSTTL 1323
N E+ +TKL+E+ H E+ + Q T+++ +L +Q ++ T+L
Sbjct: 310 NLLKKEQDYTKLEEK----HNEESV-----SKKNIQATLHQKDLDCQQLQSRLSASETSL 360
Query: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ 1383
RI +E E Q+ +EE+ + + +LK + L+ + ++ ++H + ++I +
Sbjct: 361 HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
Query: 1384 SK----QEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML--GLSKRLQESHDEM 1437
SK + Q + E ++ SE K + A L++++ L L +++ S +
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
Query: 1438 KSVAKEKDDLQRLQEVLQSESDQLKE---NIKEIVAKHLETEEELKVAHCCLKEQEETIN 1494
+ K K Q Q + QS + +L+E ++++++ + + +++++ L++ +E I+
Sbjct: 481 HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
Query: 1495 ELRVNLSEKETEI------STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVN 1548
L + +I + + QL+ N LQ ++ ++ EK + + + +
Sbjct: 541 LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
Query: 1549 ELKQFKEHRKAKDSALQSIESKMLELTNRLQESQE---EIQIMIKEKEEMKRVQEALQIE 1605
++++ K H +A + S+E+ + EL ++L ES+E ++ I IK K E+ EA
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA---- 656
Query: 1606 RDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIET 1665
K +Q + Q TA N Q+K E+ + Q + L++ +
Sbjct: 657 --------------AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
Query: 1666 ENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKI 1725
+L L E E+ S+ ++ ++L + L+ + ++K + +E +DL++Q +L
Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS-KEQALQDLQQQRQLNT 761
Query: 1726 --------VHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL---EHSNDALKAQDLKIQE 1774
+ L+ +E + R + +K+ + ++++ L E LK + +
Sbjct: 762 DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821
Query: 1775 ELRIAHMHLKEQ-QETIDKLRGIVSEK----------TDKLSNMQKDLENSNAKLQEKIQ 1823
E +I H L + Q T+ +L+ + EK DKLS + L+NS ++ +++ Q
Sbjct: 822 ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
Query: 1824 ELKANEHQLITLKKDVNETQKKVS-EMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLE 1882
+ KA ++ L+K E + ++ +ME K+ K+ +L K + + L +L+ E
Sbjct: 882 KGKA---AILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
Query: 1883 EMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM----LSKEHKE 1938
++ + E+ L+ ++LK+S ++ K + +Q ELK A + L + ++
Sbjct: 939 QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ 998
Query: 1939 TVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE 1998
+ + ++++ + +IS +Q + +KS++ ++ + +E +LL ++D
Sbjct: 999 QLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD---------- 1048
Query: 1999 MEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQF 2058
LK E +L+ + + + Q+ + ++ ++E++ ++ KE ER +
Sbjct: 1049 ---LKSVEEKLSLAQEDLISNRNQIGNQ-NKLIQELKTAKATLEQDSAKKEQQLQERCKA 1104
Query: 2059 IATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDH-YECL 2117
+ +D Q + EK L+++ + L E KC + KE+ K E+ H E +
Sbjct: 1105 L--------QDIQKEKSLKEKELVNE-KSKLAEIEEIKCRQEKEITKLNEELKSHKLESI 1155
Query: 2118 NRL-SLDLEKEIEFQKELSMRVKA-NLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKY 2175
+ +L K++ Q++L ++ KA +L Q K +++ ++ K+ +
Sbjct: 1156 KEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILK---------DQVKKEEEE 1206
Query: 2176 VLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNM 2235
+ + + + H I + E+ E + +L ++I L ++ +E Q+
Sbjct: 1207 LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEW------QSS 1260
Query: 2236 DLHIEEILK--DFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEN 2293
+ E+ K D E ++ Q +N+ E LE L +IEKL+
Sbjct: 1261 QRRVSELEKQTDDLRGEIAVLEATVQ---NNQDERRALLERCLKGEGEIEKLQT------ 1311
Query: 2294 DRICQVNNFFNNRIIAIM-----NESTEFEERSATISKEWEQD 2331
++ ++ +N A+ N+S + + A ++++W +D
Sbjct: 1312 -KVLELQRKLDNTTAAVQELGRENQSLQIKHTQA-LNRKWAED 1352
Score = 194 bits (492), Expect = 1e-48
Identities = 271/1306 (20%), Positives = 562/1306 (43%), Gaps = 142/1306 (10%)
Query: 1383 QSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK 1442
Q Q+ ++KE+ + ++ E+E+++ + + + S LQ +++
Sbjct: 90 QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQT 149
Query: 1443 EKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSE 1502
E ++++++++ + ++ QL I +I +K+ E E L+ A E+ + L L++
Sbjct: 150 ENFNIKQMKDLFEQKAAQLATEIADIKSKYDE-ERSLREA------AEQKVTRLTEELNK 202
Query: 1503 KETEISTIQKQLEAINDKLQNK-IQEIYE-KEEQFNIKQISE--VQEKVNELKQFKEHRK 1558
+ T I ++ +L LQ I+++ K+E ++ + + E+ E ++ K+ K
Sbjct: 203 EATVIQDLKTEL------LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECK 256
Query: 1559 AKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENT--KEI 1616
S S E+ + +L + L + +E+ + ++E +++K L + L EN KE
Sbjct: 257 KLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
Query: 1617 VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHE 1676
E + E K +K + + L+ + + +L I E L E
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-------LSE 369
Query: 1677 NLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQET 1736
E + + +E ++ + + LK E QL++ E L+ Q E+ +H L E +
Sbjct: 370 KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429
Query: 1737 IDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR-- 1794
+ + G + E+ S D E L+ + +++E+L+ + E Q +DK +
Sbjct: 430 LGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ 489
Query: 1795 -----GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849
+ T KL Q DLE ++ +K Q+++ E L K++++ +K+ ++
Sbjct: 490 HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549
Query: 1850 EQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLK 1909
+ + ++ L++L+ +N L +++ + E++K+ + ++ ++ +E L + + K
Sbjct: 550 YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKN---QSESHKQAQENLHDQVQEQK 606
Query: 1910 ESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKI-----------SEKTIQISDIQ 1958
L+ + R L ++ + E KE V +L +I + KT Q +D+Q
Sbjct: 607 AHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQ 666
Query: 1959 KDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRM 2018
LD +++ LQ K QEL K QL +V + + +++E K+++ + LS++
Sbjct: 667 NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE 726
Query: 2019 DNFQLTKKLHESLEEIRI----VAKERDELRRIKESLKMERDQFIATL---REMIARDRQ 2071
+ KKL E++ ++ + R++ L++ + L +E+++ R
Sbjct: 727 ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786
Query: 2072 NHQVKPEKRLLSDGQQHLTESLREK--CSRIKELLKRYSEMDDHYECLNRLSLDLE--KE 2127
+ Q K E L +Q LT+ EK + E L + +++ H E NR+ + ++
Sbjct: 787 DLQKKSE--ALESIKQKLTKQEEEKQILKQDFETLSQETKI-QHEELNNRIQTTVTELQK 843
Query: 2128 IEFQKELSM----RVKANLSLPYLQTKH----IEKLFTANQRCSMEFHRIMKKLKYVLSY 2179
++ +KE M VK LS K+ EK + ++ + K+LK+ L
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL-- 901
Query: 2180 VTKIKEEQHESINKFEMDFIDEVEKQKE----LLIKIQHLQQDCDVPSRELR-DLKLNQN 2234
+ Q E+ K + + +EK+KE L +++ +Q+ L+ + K Q
Sbjct: 902 -----QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 2235 MDLHIEEILKDFSESEFPSI-------------KTEFQQVLSNRKEMTQFLEEWLNTRFD 2281
+ +I E LK SE + I KTE + L ++++TQ +E +
Sbjct: 957 LQGNINE-LKQSSEQKKKQIEALQGELKIAVLQKTELENKL--QQQLTQAAQELAAEKEK 1013
Query: 2282 IEKLKNGIQKENDRICQVNNFFNNR---IIAIMNESTEFEERSATISKEWEQDLKSLKEK 2338
I L+N +K + Q+ + F R ++A + EE+ + ++ + + +
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073
Query: 2339 NEKLFKNYQTLKTSLA--SGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKES 2396
N KL + +T K +L S + + K + L +++ ++ L E +E
Sbjct: 1074 N-KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEI 1132
Query: 2397 AMHKESKIIKMQKEL---------EVTNDIIAK---------LQAKVHESNKCLEKTKET 2438
+E +I K+ +EL E+TN AK LQ K +E+ K
Sbjct: 1133 KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN 1192
Query: 2439 IQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRL 2498
Q+L+D+V + K+E + + KL EK K+ E+ + + E +
Sbjct: 1193 QQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
Query: 2499 LRENLRRSQQAQDTSVISEHTDP---------------QPSNKPL--TCGGGSGIVQ--N 2539
+++ + SQ+ S + + TD Q + L C G G ++
Sbjct: 1253 VKKEWQSSQRR--VSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ 1310
Query: 2540 TKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVK 2585
TK L L+ + + +L ++N+ L + + L+ NEV+
Sbjct: 1311 TKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
Score = 186 bits (473), Expect = 2e-46
Identities = 261/1195 (21%), Positives = 519/1195 (43%), Gaps = 174/1195 (14%)
Query: 325 TAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKD 384
T + K + ++ T E L + +++ LKK+L +V +E+++ ++ L KD
Sbjct: 197 TEELNKEATVIQDLKT-ELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL--KD 253
Query: 385 LLQKVQNEKIENLTRMLVTSSSLTLQQ---ELKAKRKRRVTWCLGKINKMKNSNYADQFN 441
+K+Q++ SS T+ Q EL AK + V + ++ K+K+S
Sbjct: 254 ECKKLQSQ---------YASSEATISQLRSEL-AKGPQEVAVYVQELQKLKSS------- 296
Query: 442 IPTNITTKTHKLSINLLREI-----------DESVCS---ESDVFSNTLD---------- 477
+T K L+ NLL++ +ESV ++ + LD
Sbjct: 297 -VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355
Query: 478 ---TLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMEL-------- 526
+L I + K + ++ EL+ + Y +L +++QL+ ++EE E
Sbjct: 356 SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415
Query: 527 --------------------KLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHA 566
+LKE+ L E L K ++ ++QL ++S L+ +K
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSS-EKLMDKEQQVADLQL--KLSRLEEQLKEK 472
Query: 567 EVYNQDLENELS--------------SKVELLREKEDQIKKLQEYIDS--QKLENIKMDL 610
+ +L+++L S LRE ++ ++++ I QK++N++ L
Sbjct: 473 VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
Query: 611 SYSLESIEDPKQMKQTLF------DAETVALDAKRESAFLRSENL-ELKEKMKELATTYK 663
S E+I ++ ++ L+ + ET L+ +E E + +L EK+K + ++K
Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592
Query: 664 Q----MENDIQLYQSQLEAKKKMQVDLE---KELQSAFNEITKLTSLIDGKVPKDLLCNL 716
Q + + +Q ++ L A + + LE EL S NE + S +D ++ L
Sbjct: 593 QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 652
Query: 717 ELEGKITDLQKELNKEVEENE-ALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITS 775
E T + +L ++ + AL+++ EL + ++++++ ++QDK E + S
Sbjct: 653 SAEAAKTAQRADLQNHLDTAQNALQDKQ---QELNKITTQLDQVTAKLQDKQEHCSQLES 709
Query: 776 EKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKM 835
+ + + E + + L +I K + D +++ + Q+ Q + L+ D E +
Sbjct: 710 HLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATE 769
Query: 836 VLEENERMNQEIVNLSK-EAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE 894
+ ++ E M +EIV+ ++ + QK +L ++K +L+ + +E Q ++ + E + E
Sbjct: 770 LSKQLE-MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHE 828
Query: 895 QLENRDSTLQTVEREKTLITEKLQQTLEEVK-TLTQEKDDLKQLQESLQIERDQLKSDIH 953
+L NR T T ++ + E L L VK L++ D LK + + E + K+ I
Sbjct: 829 ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL 888
Query: 954 DTVNMNIDTQEQLRNALE-SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKM 1012
D + + QL+ +E +LK+ +E +L+ + +E S L +E N+ Q+++
Sbjct: 889 DLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE--KEASHQLKLELNS------MQEQL 940
Query: 1013 VGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTD 1072
+ K Q L ++ + + +Q+K ++ LQ L+ + +K +L+
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKK-----KQIEALQGELKIAVLQKTELENK 995
Query: 1073 LKENIEMTIE----NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEK 1128
L++ + + +E++ +L + +K QE Q ++ +E EL T L VEEK
Sbjct: 996 LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055
Query: 1129 LKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKL 1188
L Q+ L++ + ++ K I E++ K L+ E ER + Q +
Sbjct: 1056 -------LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDI 1108
Query: 1189 -NENYEEVKSITKERKVL-----------KELQKSFETERDHLRGYIREIEATGLQTKEE 1236
E + K + E+ L KE+ K E + H I+EI T L+ ++
Sbjct: 1109 QKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI--TNLKDAKQ 1166
Query: 1237 LKIAHIHLKEHQETIDELRRSV-SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295
L I E Q D L+ +V EK Q I ++K +L++E + +E +L +
Sbjct: 1167 LLIQ--QKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEF--IEKEAKLHSEI 1222
Query: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK 1355
KE + E E T + L ++ E +Q SQ + L K+ D+L+
Sbjct: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKE-------WQSSQRRVSELEKQTDDLR 1275
Query: 1356 ----TIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEM 1406
++ ++ D+ + + L E + Q + L ++ K + TT V E+
Sbjct: 1276 GEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
Score = 175 bits (444), Expect = 5e-43
Identities = 274/1274 (21%), Positives = 531/1274 (41%), Gaps = 214/1274 (16%)
Query: 1434 HDEMKSVAKEKDDLQRLQEVLQSESDQLKEN--IKEIVAKHLETEEELKVAHCCLKEQEE 1491
H ++A ++DD+ L++ +Q LKE E + K LE + L+ +QE
Sbjct: 72 HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ-------QQEA 124
Query: 1492 TINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEK----- 1546
+ L +++ E+ ++++QLE + E FNIKQ+ ++ E+
Sbjct: 125 KPDGL---VTDSSAELQSLEQQLEEA-------------QTENFNIKQMKDLFEQKAAQL 168
Query: 1547 VNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIER 1606
E+ K + S ++ E K+ LT L + IQ + E + +++ +++
Sbjct: 169 ATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKK 228
Query: 1607 DQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETE 1666
+ ++ T ++ M +E+E + LK E + L+ Q+ + + + + +E
Sbjct: 229 ELVQVQT--LMDNMTLERERESEKLKD-----------ECKKLQSQYASSEATISQLRSE 275
Query: 1667 NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIV 1726
L + +E+ +E L+S L + L ENL + ++Q+ K+
Sbjct: 276 -------LAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK------KEQDYTKLE 322
Query: 1727 HMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQ 1786
H +E VS+K + + QKDL+ L+++ + L H+ L E+
Sbjct: 323 EKHNEES----------VSKKNIQATLHQKDLDCQQ--LQSRLSASETSLHRIHVELSEK 370
Query: 1787 QETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQ-------ELKANEHQLITLKKDV 1839
E KL+ +SE K +++ + + + +EK Q E+ +L+ ++ +
Sbjct: 371 GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL 430
Query: 1840 NETQKKVSEMEQL--------KKQIKDQSLTLSKLEI---ENLNLAQKLHENLEEMKSVM 1888
E ++ E QL ++Q+ D L LS+LE E + + +L L++ K
Sbjct: 431 GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH 490
Query: 1889 KERDNLRRVEETLKLERDQ--LKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREK 1946
+E+ L++ T KL Q L++ L++ +D +IQ L+ SKE+ ++K RE
Sbjct: 491 QEQQALQQ-STTAKLREAQNDLEQVLRQIGDKDQKIQN-LEALLQKSKENISLLEKERED 548
Query: 1947 ISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE-----MEQ 2001
+ K IQ + + + ++LQ+K LQ++ QL ++ + SHK+ E +++
Sbjct: 549 LYAK-IQAGEGETAV---LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE 604
Query: 2002 LKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIR---IVAKERDELRRIKESLKMERDQF 2058
K A + S+ +L +L+ES E++ I K + EL E+ K +
Sbjct: 605 QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ--- 661
Query: 2059 IATLREMIARDRQNHQVKPEKRLLSDGQQHLT-------------ESLREKCSRIKELLK 2105
D QNH + + L D QQ L + +E CS+++ LK
Sbjct: 662 --------RADLQNH-LDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
Query: 2106 RYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSME 2165
Y E Y L + + +LE +I+ + S+ VKA+ + +L T + + E
Sbjct: 713 EYKEK---YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATE 769
Query: 2166 FHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRE 2225
+ ++ K ++S +++ E++ + + E+++ L + L Q+ + E
Sbjct: 770 LSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEE 829
Query: 2226 LRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKL 2285
L N + + E+ K E E ++ TE V +++ L+
Sbjct: 830 L-----NNRIQTTVTELQKVKMEKE--ALMTELSTVKDKLSKVSDSLKN----------S 872
Query: 2286 KNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKN 2345
K+ +KEN + AI++ +E + + E LK KE + L K
Sbjct: 873 KSEFEKENQK----------GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
Query: 2346 YQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKI-RELENSLHEAKESAMHKESKI 2404
+ + Q+ + + ++ T EK ++L+ +++E K+S+ K+ +I
Sbjct: 923 KE-------ASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975
Query: 2405 IKMQKELEVT----NDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL 2460
+Q EL++ ++ KLQ ++ ++ + L KE I VLQ+ + +K+ D
Sbjct: 976 EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 2461 -------------------KMKLVKIDL----EKMKNAKEFEKEISATKATVEYQK-EVI 2496
K+ L + DL ++ N + +E+ KAT+E +
Sbjct: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
Query: 2497 RLLRENLRRSQQAQDTSVISEHTDPQPSNK-----PLTCGGGSGIVQNTKALILKSEHIR 2551
+ L+E + Q Q + E +K + C I + + L KS +
Sbjct: 1096 QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL--KSHKLE 1153
Query: 2552 LEKEISKLKQQNEQLIKQKNELLS--------------NNQHLSNEVKTWKERTLKREAH 2597
KEI+ LK + LI+QK EL N Q L ++VK +E K
Sbjct: 1154 SIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIE 1213
Query: 2598 KQVTCENSPKSPKV 2611
K+ + K +V
Sbjct: 1214 KEAKLHSEIKEKEV 1227
Score = 155 bits (393), Expect = 4e-37
Identities = 219/992 (22%), Positives = 444/992 (44%), Gaps = 163/992 (16%)
Query: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQ-AMEKDQLAQLLEEKDLLQKV------ 389
++S E LK +L+ QL++ + + Q A+++ A+L E ++ L++V
Sbjct: 461 KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520
Query: 390 QNEKIENLTRMLVTSS-SLTLQQELKAKRKRRVTWCLGK---INKMKNSNYADQFNIPTN 445
+++KI+NL +L S +++L ++ + ++ G+ +N+++ N+ Q
Sbjct: 521 KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ----EQ 576
Query: 446 ITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRA 505
+T T KL ++S+ + L + ++ + LRA
Sbjct: 577 VTQLTEKLK------------NQSESHKQAQENL-------------HDQVQEQKAHLRA 611
Query: 506 DYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKH 565
D ++ L T E+ +L E + + L+ + K E+ L E +
Sbjct: 612 AQDRVL----SLETSVNELNSQLNESKE--KVSQLDIQIKAKTELLLSAEAAKTAQ---- 661
Query: 566 AEVYNQDLENELSSKVELLREKEDQIKKLQEYID--SQKLENIKMDLSYSLESIEDPKQM 623
DL+N L + L++K+ ++ K+ +D + KL++ K + LES K+
Sbjct: 662 ----RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD-KQEHCSQLES--HLKEY 714
Query: 624 KQTLFDAETVALDAKRESAFLRSENLELK---EKMKELATTYKQMENDIQLYQSQLEAKK 680
K+ E + + + L +++LE+K E+ + +Q+ D++L ++L
Sbjct: 715 KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK-- 772
Query: 681 KMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK---ITDLQKELNKEVEENE 737
Q+++EKE+ S+ L+L+ K + ++++L K+ EE +
Sbjct: 773 --QLEMEKEIVSS--------------------TRLDLQKKSEALESIKQKLTKQEEEKQ 810
Query: 738 ALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEE 797
L+++ LS+ + + E L IQ EL + EK+ L +E+ + ++
Sbjct: 811 ILKQDFETLSQETKI--QHEELNNRIQTTVTELQKVKMEKEALMTEL-------STVKDK 861
Query: 798 IGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEE----NERMNQEIVNLSKE 853
+ K D L ++S + ++E Q K +D E+ K + + E +E L K
Sbjct: 862 LSKVSDSLKNSKSEF---EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
Query: 854 AQKFDSSLGALKTELSYKTQEL----------QEKTREVQERLNEM----EQLKEQLENR 899
+K + LK EL+ ++L +++ +++Q +NE+ EQ K+Q+E
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
Query: 900 DSTLQTVEREKTLITEKLQQTLEEV-KTLTQEKDDLKQLQESLQIERD---QLKSDIHDT 955
L+ +KT + KLQQ L + + L EK+ + LQ + + ++ QL+SD +
Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038
Query: 956 VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI 1015
+ + T++ L++ E L QE + + +++I + L E T + E
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ--NKLIQELKTAKATLE-------- 1088
Query: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS--LIQEKNELQQMLESVIAEKEQLKTDL 1073
QD AK Q L K + I++++ + L+ EK++L + +E + +E+ T L
Sbjct: 1089 ---QD-SAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAE-IEEIKCRQEKEITKL 1143
Query: 1074 KENIEM-TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEK 1132
E ++ +E+ +E+ LK ++++ Q+K EL D L E+ K
Sbjct: 1144 NEELKSHKLESIKEIT----NLKDAKQLLIQQKL-------ELQGKADSLKAAVEQEKRN 1192
Query: 1133 SQQLQEKQQQLLNVQEEMSEMQKKINEIE-NLKNELKNKELTLEHMETERLELAQKLNEN 1191
Q L+++ V++E E++K+ E E L +E+K KE+ ++ E +L ++
Sbjct: 1193 QQILKDQ------VKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITAL 1246
Query: 1192 YEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETI 1251
E + ++ KE + + E + D LRG I +EAT ++E + + + I
Sbjct: 1247 NENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEI 1306
Query: 1252 DELRRSVSEKTAQIINT----QDLEKSHTKLQ 1279
++L+ V E ++ NT Q+L + + LQ
Sbjct: 1307 EKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
>gi|38569484 kinesin family member 21A [Homo sapiens]
Length = 1661
Score = 244 bits (622), Expect = 1e-63
Identities = 287/1207 (23%), Positives = 502/1207 (41%), Gaps = 209/1207 (17%)
Query: 3 EEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNV 62
+E +V V VR+RP ++E+ G ++ + K+F FD VF + + +
Sbjct: 6 DESSVRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVF-LGKDKAFTFDYVFDIDSQQEQI 64
Query: 63 YEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGS------EDHLGVIPRAIHDIFQK 116
Y + +I+ +GYN T+FAYGQT +GKTYTM E+ LG+I RA+ +F+
Sbjct: 65 YIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKS 124
Query: 117 IKK---------FPDREFLLRVSYMEIYNETITDLLCGTQ------KMKPLIIREDVNRN 161
I++ P +F + ++E+YNE + DL T+ K + I ED
Sbjct: 125 IEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLFDTTRDIDAKSKKSNIRIHEDSTGG 184
Query: 162 VYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIF-------------- 207
+Y +T V T ++ + G SR T+MN +SSRSH IF
Sbjct: 185 IYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQID 244
Query: 208 -------RMILESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINR 260
++I ES + E + + VDLAGSER +TGA G R KEG +IN
Sbjct: 245 ADNATDNKIISESAQMN-----EFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINC 299
Query: 261 SLFILGQVIKKLSD-GQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPV--SFDETL 317
L LG VI L D + + YRDSKLTR+LQ+SLGGN++T +I ++P F ETL
Sbjct: 300 GLLALGNVISALGDKSKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETL 359
Query: 318 TALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLA 377
L++A+ A+ +KN VN+ R ++I L+ ++ + +E
Sbjct: 360 NTLKYANRARNIKNKVMVNQ--------DRASQQINALRSEITRLQME------------ 399
Query: 378 QLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYA 437
L+E K + + E +E++ M ++ L + R + + + + +
Sbjct: 400 -LMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRSRITQLVS 458
Query: 438 DQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDT-LSEIEWNPATKLLNQENI 496
DQ N ++L E ++ SN + + + EIE + KLL E +
Sbjct: 459 DQAN--------------HVLARAGEG----NEEISNMIHSYIKEIE-DLRAKLLESEAV 499
Query: 497 ESELN------SLRADY--DNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKK-- 546
L + RA Y + L ++KE +E+ K DL++ + E++ KK
Sbjct: 500 NENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKSV 559
Query: 547 ---------DQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEY 597
DQE + +S +N EV ++ + E E+ED I +
Sbjct: 560 AGKEDNTDTDQEKKEEKGVSEREN--NELEVEESQEVSDHEDEEEEEEEEEDDIDGGESS 617
Query: 598 IDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKE 657
+S + K + L +I +KQ L D EL+ K
Sbjct: 618 DESDSESDEKANYQADLANITCEIAIKQKLID--------------------ELENSQKR 657
Query: 658 LATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLE 717
L T KQ E + + Q ++ D + E + + S + K K E
Sbjct: 658 LQTLKKQYEEKLMMLQHKIR-------DTQLERDQVLQNLGSVESYSEEKAKK---VRSE 707
Query: 718 LEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEK 777
E K+ + KEL + A +E LL ++++L++++ + + K
Sbjct: 708 YEKKLQAMNKELQR---LQAAQKEHARLLKNQSQYEKQLKKLQQDVME-------MKKTK 757
Query: 778 DKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVL 837
+L ++ KE + + L E + + ++A + + + D + + + + E +
Sbjct: 758 VRLMKQM--KEEQEKARLTESRRNR-EIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKT 814
Query: 838 EENERMNQEIVNLSKE---------------AQKFDSSLGALKTELSYKTQELQEKTREV 882
EE + +++ +S + AQ SS A++T+ S Q+K R
Sbjct: 815 EEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDAS--RTGAQQKMRIP 872
Query: 883 QERL----------NEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD 932
R+ N + ++ L R +T + L+ ++ + + T++ +
Sbjct: 873 VARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEA 932
Query: 933 DLKQL---QESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISE 989
D+ +L +E L R++L V N + + + N E ++ I+ + IS+
Sbjct: 933 DMNRLLKQREELTKRREKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSISD 992
Query: 990 EVSRNLHMEE--NTGETKD-----------EFQQKM-----VGIDKKQDLEAKNTQ--TL 1029
+ + MEE GET D E + + +GI+K K Q L
Sbjct: 993 CQANIMQMEEAKEEGETLDVTAVINACTLTEARYLLDHFLSMGINKGLQAAQKEAQIKVL 1052
Query: 1030 TADVKDNEIIE--QQRKIFSLIQEKNELQQMLESVIAEK-EQLKTDLKENIEMTIENQEE 1086
+K EI Q + +F +++EK EL L++++ + L + EN+E + +
Sbjct: 1053 EGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSVPLENVEDSTDEDAP 1112
Query: 1087 LRLLGDE 1093
L G E
Sbjct: 1113 LNSPGSE 1119
Score = 87.0 bits (214), Expect = 2e-16
Identities = 165/758 (21%), Positives = 317/758 (41%), Gaps = 87/758 (11%)
Query: 1272 EKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERL 1331
EK H ++ +P P+ K ++ E NE E+L TT+D A+ + +
Sbjct: 127 EKKHIAIKNGLPA--------PDFKVNAQFLELYNE-EVLDLFDTTRDID--AKSKKSNI 175
Query: 1332 RLNEKFQESQEEIKSLTKERDNLKTIKEALE-VKHDQLKEHIRETLAKIQESQSK----- 1385
R++E +S I ++ + T E ++ +K L T +Q S+S
Sbjct: 176 RIHE---DSTGGIYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTI 232
Query: 1386 ---QEQSLNMKEKDNET-TKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH---DEMK 1438
Q + + DN T KI+SE Q ++ + L S+RL+ + + K
Sbjct: 233 HVCQTRVCPQIDADNATDNKIISESAQMNEFETLTAKFHFVDLAGSERLKRTGATGERAK 292
Query: 1439 SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE--LKVAHCCLKEQEETINEL 1496
L L V+ + D+ K A H+ + ++ L +TI
Sbjct: 293 EGISINCGLLALGNVISALGDKSKR------ATHVPYRDSKLTRLLQDSLGGNSQTIMIA 346
Query: 1497 RVNLSEKE--TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK 1554
V+ S+++ ++T++ A N ++NK+ ++ Q SE+ EL ++K
Sbjct: 347 CVSPSDRDFMETLNTLKYANRARN--IKNKVMVNQDRASQQINALRSEITRLQMELMEYK 404
Query: 1555 EHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQL-KENT 1613
++ D + M LQ +++ IK M+ +AL+ QL +
Sbjct: 405 TGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIK---AMQETVDALRSRITQLVSDQA 461
Query: 1614 KEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ-FETQKLNLENIETENIR--L 1670
++A+ E E+ N + EIE L+ + E++ +N EN+R L
Sbjct: 462 NHVLARAGEGNEE--------ISNMIHSYIKEIEDLRAKLLESEAVN------ENLRKNL 507
Query: 1671 TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL 1730
T+ S T L S +ET+++ D K++L + ++ K++ + +
Sbjct: 508 TRATARAPYFSGSSTFSPTILSSDKETIEI-IDLAKKDLEKLKRKEKRKKKSVAGKEDNT 566
Query: 1731 KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI 1790
QE ++ +G+ + NE+ ++E S + +D + +EE E+++ I
Sbjct: 567 DTDQEKKEE-KGVSERENNEL-----EVEESQEVSDHEDEEEEEE---------EEEDDI 611
Query: 1791 D--KLRGIVSEKTDKLSNMQKDLENSNAKL---QEKIQELKANEHQLITLKKDVNETQKK 1845
D + ++D+ +N Q DL N ++ Q+ I EL+ ++ +L TLKK E
Sbjct: 612 DGGESSDESDSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMM 671
Query: 1846 VSEMEQLKKQIKDQSL-TLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLE 1904
+ + + +DQ L L +E + A+K+ E+ M + L+R++ K
Sbjct: 672 LQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNK--ELQRLQAAQKEH 729
Query: 1905 RDQLKESLQ---ETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDL 1961
LK Q + K ++ + KT L K+ KE +K R S + +I+ ++KD
Sbjct: 730 ARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQ 789
Query: 1962 DKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999
K +L+ + + +E+ L R E+V +++ M
Sbjct: 790 RKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPM 827
Score = 73.9 bits (180), Expect = 2e-12
Identities = 144/765 (18%), Positives = 306/765 (40%), Gaps = 106/765 (13%)
Query: 1264 QIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTL 1323
+II+ + +E + E + E L +K + ET + + +T+ + + + L
Sbjct: 408 RIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRSR--ITQLVSDQANHVL 465
Query: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ 1383
AR E +E I S KE ++L+ E ++ L++++ A+
Sbjct: 466 ARA-------GEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFS 518
Query: 1384 SKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE 1443
S + D ET +I I++ L K ++ + KSVA +
Sbjct: 519 GSSTFSPTILSSDKETIEI----------------IDLAKKDLEKLKRKEKRKKKSVAGK 562
Query: 1444 KDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEK 1503
+D+ QE + + +EN LE EE +V+ +E+EE E ++ E
Sbjct: 563 EDNTDTDQEKKEEKGVSEREN------NELEVEESQEVSDHEDEEEEEEEEEDDIDGGES 616
Query: 1504 ETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHR------ 1557
E + + L N EI K++ I ++ Q+++ LK+ E +
Sbjct: 617 SDESDSESDEKANYQADLANITCEIAIKQKL--IDELENSQKRLQTLKKQYEEKLMMLQH 674
Query: 1558 KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIV 1617
K +D+ L+ ++L+ ++ EE ++ + E K +++R Q + +
Sbjct: 675 KIRDTQLE--RDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARL 732
Query: 1618 AKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHEN 1677
K + EK+ + L+ + + K+ ++ +KE+ E +L TE+ R
Sbjct: 733 LKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARL------TESRR-------- 778
Query: 1678 LEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETI 1737
R + + + D R + L++ Q K N + R E+ L+ ++ +
Sbjct: 779 ---NREIAQLKKDQRKRDHQLRLLEAQ-KRNQEVVLRRKTEEVTALR------RQVRPMS 828
Query: 1738 DKLRGIVSEKTNEISNMQKDLEHSNDALK--AQDLKIQEELRI--AHMHLKEQQETIDKL 1793
DK+ G V+ K + +D S A++ A Q+++RI A + T
Sbjct: 829 DKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRIPVARVQALPTPATNGNR 888
Query: 1794 RGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK 1853
+ + + K L+ ++ ++ + + ++ D+N K+ E+ + +
Sbjct: 889 KKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLKQREELTKRR 948
Query: 1854 KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913
+++ + + K EN E K+V N+ E+L D + +S+
Sbjct: 949 EKLSKRREKIVK-------------ENGEGDKNVA----NINEEMESLTANIDYINDSIS 991
Query: 1914 ETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQIS----------DIQKDLDK 1963
+ +A +++++ +KE ET+D + I+ T+ + I K L
Sbjct: 992 DCQANIMQMEE--------AKEEGETLD-VTAVINACTLTEARYLLDHFLSMGINKGLQA 1042
Query: 1964 SKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEA 2008
++ E Q K+ E + K+ ++ ++ + H + E +L + +A
Sbjct: 1043 AQKEAQIKVLEGRLKQTEITSATQNQLLFH-MLKEKAELNPELDA 1086
Score = 70.1 bits (170), Expect = 3e-11
Identities = 169/871 (19%), Positives = 356/871 (40%), Gaps = 136/871 (15%)
Query: 776 EKDKLFSEVVHKESRVQGLLEEI--GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKY 833
+K K + V +++S++ LL++ G ++ + S +D++F M+
Sbjct: 313 DKSKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACVS---PSDRDF-------METLNTL 362
Query: 834 KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQE-KT------REVQERL 886
K N+ +VN + +Q+ + AL++E++ EL E KT E E +
Sbjct: 363 KYANRARNIKNKVMVNQDRASQQ----INALRSEITRLQMELMEYKTGKRIIDEEGVESI 418
Query: 887 NEMEQLKEQLENRDSTL--------QTVEREKTLITEKLQQTLEEVKTLTQE-KDDLKQL 937
N+M L+ ++ L +TV+ ++ IT+ + V E +++ +
Sbjct: 419 NDMFHENAMLQTENNNLRVRIKAMQETVDALRSRITQLVSDQANHVLARAGEGNEEISNM 478
Query: 938 QESLQIERDQLKSDIHDTVNMNIDTQEQLRNA------------------------LESL 973
S E + L++ + ++ +N + ++ L A +E +
Sbjct: 479 IHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEII 538
Query: 974 KQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADV 1033
++ + LK K + E+NT +++ ++K V + +LE + +Q +V
Sbjct: 539 DLAKKDLEKLKRKEKRKKKSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQ----EV 594
Query: 1034 KDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDE 1093
D+E E++ + + E +S EK + DL NI I +++L DE
Sbjct: 595 SDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQADLA-NITCEIAIKQKLI---DE 650
Query: 1094 LKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEM 1153
L+ +Q++ +KK+ E ++L ++ K+++ + + Q L +V+ E
Sbjct: 651 LEN-----SQKRLQTLKKQYE-----EKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEK 700
Query: 1154 QKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQK--- 1210
KK+ K + NKEL +RL+ AQK E+ +K+ ++ K LK+LQ+
Sbjct: 701 AKKVRSEYEKKLQAMNKEL-------QRLQAAQK--EHARLLKNQSQYEKQLKKLQQDVM 751
Query: 1211 SFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID-ELRRSVSEKTAQIINTQ 1269
+ + L ++E + T+ LK+ Q D +LR ++K Q + +
Sbjct: 752 EMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLR 811
Query: 1270 DLEKSHTKLQEEIPVLHEEQELLPNVKEVSE---TQETMNELELLTEQSTTKDSTTLARI 1326
+ T L+ ++ + ++ K S Q+T + + ++ + RI
Sbjct: 812 RKTEEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRI 871
Query: 1327 EMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQ 1386
+ R++ + K K I + +K L+ + + +
Sbjct: 872 PVARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIM--------- 922
Query: 1387 EQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD 1446
Q + + + + +++ + E+ + L + K ++E+ + K+VA ++
Sbjct: 923 -QKMTISNMEADMNRLLKQREELTKRREKLSKRR------EKIVKENGEGDKNVANINEE 975
Query: 1447 LQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506
+ E L + D + ++I + A ++ EE KE+ ET++ V + TE
Sbjct: 976 M----ESLTANIDYINDSISDCQANIMQMEE--------AKEEGETLDVTAVINACTLTE 1023
Query: 1507 I---------STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHR 1557
I K L+A + Q K+ E + +Q I ++ Q + LK+ E
Sbjct: 1024 ARYLLDHFLSMGINKGLQAAQKEAQIKVLE--GRLKQTEITSATQNQLLFHMLKEKAELN 1081
Query: 1558 KAKDS----ALQSIESKMLELTNRLQESQEE 1584
D+ ALQ ++S LE +++S +E
Sbjct: 1082 PELDALLGHALQDLDSVPLE---NVEDSTDE 1109
Score = 47.4 bits (111), Expect = 2e-04
Identities = 136/760 (17%), Positives = 305/760 (40%), Gaps = 105/760 (13%)
Query: 1883 EMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQEL---KTA-RMLSKEHKE 1938
E + +K + R ++ + + +D+ + + ++ +Q EL KT R++ +E E
Sbjct: 357 ETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMELMEYKTGKRIIDEEGVE 416
Query: 1939 TVDKLREKISEKTIQISDIQ---KDLDKSKDELQKKIQELQKKELQLLRVK------EDV 1989
+++ + + + + ++++ K + ++ D L+ +I +L + + + E
Sbjct: 417 SINDMFHENAMLQTENNNLRVRIKAMQETVDALRSRITQLVSDQANHVLARAGEGNEEIS 476
Query: 1990 NMSHKKINEMEQLK-KQFEAQ--------NLSMQSVRMDNFQLTKKLHESL-----EEIR 2035
NM H I E+E L+ K E++ NL+ + R F + ++ E I
Sbjct: 477 NMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIE 536
Query: 2036 IVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLRE 2095
I+ + +L ++K K ++ +A + D++ K EK + L +
Sbjct: 537 IIDLAKKDLEKLKRKEKRKKKS-VAGKEDNTDTDQEK---KEEKGVSERENNELEVEESQ 592
Query: 2096 KCSRIKELLKRYSEMDDHY---ECLNRLSLDLEKEIEFQKELS-----MRVKANL----- 2142
+ S ++ + E +D E + + +++ +Q +L+ + +K L
Sbjct: 593 EVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQADLANITCEIAIKQKLIDELE 652
Query: 2143 ----SLPYLQTKHIEKLFTANQRC---SMEFHRIMKKLKYVLSYVTKIKEEQHESINKFE 2195
L L+ ++ EKL + +E ++++ L V SY E K
Sbjct: 653 NSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESY-------SEEKAKKVR 705
Query: 2196 MDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIK 2255
++ +++ + L ++Q Q++ R LK + ++++ +D E + K
Sbjct: 706 SEYEKKLQAMNKELQRLQAAQKE------HARLLKNQSQYEKQLKKLQQDVMEMK--KTK 757
Query: 2256 TEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNEST 2315
+ + +E + E N +I +LK +K + ++ + N+ + + ++
Sbjct: 758 VRLMKQMKEEQEKARLTESRRNR--EIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKT- 814
Query: 2316 EFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNP----TTQDNKNPHV 2371
EE +A + K + KL + + + +S A V T K
Sbjct: 815 --EEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRIP 872
Query: 2372 TSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKEL---EVTNDIIAKLQAKVHES 2428
+R L T + SK +M+ +L VT+ I+ K+ E+
Sbjct: 873 VARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEA 932
Query: 2429 --NKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATK 2486
N+ L++ +E + +E++ + K+VK + E KN +E+ +
Sbjct: 933 DMNRLLKQREELTK------------RREKLSKRREKIVKENGEGDKNVANINEEMESLT 980
Query: 2487 ATVEYQKEVIRLLRENLRRSQQAQD-------TSVISEHTDPQPS---NKPLTCGGGSGI 2536
A ++Y + I + N+ + ++A++ T+VI+ T + + L+ G G+
Sbjct: 981 ANIDYINDSISDCQANIMQMEEAKEEGETLDVTAVINACTLTEARYLLDHFLSMGINKGL 1040
Query: 2537 VQNTKALILKSEHIRLEKEISKLKQQNE---QLIKQKNEL 2573
K +K RL++ QN+ ++K+K EL
Sbjct: 1041 QAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAEL 1080
>gi|41352705 kinesin family member 3C [Homo sapiens]
Length = 793
Score = 243 bits (621), Expect = 1e-63
Identities = 161/394 (40%), Positives = 224/394 (56%), Gaps = 45/394 (11%)
Query: 6 AVAVCVRVRPLNSREESLG---------ETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGN 56
A+ V R RPL+ +EE+ G + QV + ++ K+F FD V+ +
Sbjct: 10 ALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELP--KTFTFDAVYDAS 67
Query: 57 ETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGS--EDHL-GVIPRAIHDI 113
++Y+E P+IDS +QG+NGT+FAYGQT +GKTYTM G+ E L GVIP A I
Sbjct: 68 SKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHI 127
Query: 114 FQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVY 173
F I + ++++L+R SY+EIY E I DLL + K L ++E+ VY+ DL+ V
Sbjct: 128 FTHISRSQNQQYLVRASYLEIYQEEIRDLL-SKEPGKRLELKENPETGVYIKDLSSFVTK 186
Query: 174 TSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNL 233
+ + G ++R G T MN+ SSRSH IF + +E E+G S+ + ++V LNL
Sbjct: 187 NVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERG--SDGQDHIRVGKLNL 244
Query: 234 VDLAGSERAAQT------------------------GAAGVRLKEGCNINRSLFILGQVI 269
VDLAGSER + GA G R KE IN SL LG VI
Sbjct: 245 VDLAGSERQNKAGPNTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVI 304
Query: 270 KKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPV--SFDETLTALQFASTAK 327
L+ G I YRDSKLTR+LQ+SLGGNAKT ++ T+ P S+DE+L+ L+FA+ AK
Sbjct: 305 AALA-GNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAK 363
Query: 328 YMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEE 361
+KN P VNE D LL+ +++EI LK QLE+
Sbjct: 364 NIKNKPRVNEDPKD-TLLREFQEEIARLKAQLEK 396
Score = 49.3 bits (116), Expect = 5e-05
Identities = 70/345 (20%), Positives = 145/345 (42%), Gaps = 62/345 (17%)
Query: 847 IVNLSKEAQKFDSSLGALKTELSYKTQELQEKTRE------VQERLNEMEQLKEQLENRD 900
+ L + +D SL L+ K + + + E ++E E+ +LK QLE R
Sbjct: 339 VATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKRG 398
Query: 901 STLQTVEREKTLITEKL-------QQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH 953
+ R+ + + + + + E +E D+ + I L+
Sbjct: 399 MLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILESALEK--- 455
Query: 954 DTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMV 1013
NM QEQ E L++ + I +S +SEE + L +E E
Sbjct: 456 ---NMENYLQEQK----ERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLE---------- 498
Query: 1014 GIDKKQDLEAKNTQTLTADVK--DNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKT 1071
D +++ +A T+ L A K +++++ R I E+ ++ ++ IAE+++ +
Sbjct: 499 --DLRREQQA--TELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRRER 554
Query: 1072 DLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE 1131
++++ EM + ++E + L G QQE+ + K +L ++ KL+
Sbjct: 555 EMQQ--EMMLRDEETMELRGTYTSLQQEVEVKTK---------------KLKKLYAKLQA 597
Query: 1132 KSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEH 1176
++Q++ + + V++++ E Q + ELK K L +E+
Sbjct: 598 VKAEIQDQHDEYIRVRQDLEEAQNE------QTRELKLKYLIIEN 636
Score = 48.9 bits (115), Expect = 7e-05
Identities = 47/202 (23%), Positives = 99/202 (49%), Gaps = 25/202 (12%)
Query: 1805 SNMQKDLENSNAKLQEKIQELKA---NEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSL 1861
S ++K++EN + +E+++E KA ++ L++ E QK + E E++ + ++ +
Sbjct: 451 SALEKNMENYLQEQKERLEEEKAAIQDDRSLVS-----EEKQKLLEEKEKMLEDLRREQQ 505
Query: 1862 TLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLE 1921
L + + KL L +++M D+ ++ L+L+R ++ E K R+ E
Sbjct: 506 ATELLAAKYKAMESKL---LIGGRNIM---DHTNEQQKMLELKRQEIAEQ----KRRERE 555
Query: 1922 IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQ 1981
+QQE+ + E + T L++++ KT K L K +LQ E+Q + +
Sbjct: 556 MQQEMMLRDEETMELRGTYTSLQQEVEVKT-------KKLKKLYAKLQAVKAEIQDQHDE 608
Query: 1982 LLRVKEDVNMSHKKINEMEQLK 2003
+RV++D+ + + +LK
Sbjct: 609 YIRVRQDLEEAQNEQTRELKLK 630
Score = 40.0 bits (92), Expect = 0.031
Identities = 39/192 (20%), Positives = 85/192 (44%), Gaps = 17/192 (8%)
Query: 2283 EKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWE---QDLKSLKEKN 2339
+ ++N +Q++ +R+ AI ++ + E + +E E +DL+ ++
Sbjct: 455 KNMENYLQEQKERL-------EEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQAT 507
Query: 2340 EKLFKNYQTLKTSLASGAQ--VNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESA 2397
E L Y+ +++ L G + ++ T + K + + + RE++ + E
Sbjct: 508 ELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEET 567
Query: 2398 MHKESKIIKMQKELEVTNDIIAKLQAKVHE-SNKCLEKTKETIQVLQDKVALGAKPYKEE 2456
M +Q+E+EV + KL AK+ + ++ E I+V QD + E+
Sbjct: 568 MELRGTYTSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQDL----EEAQNEQ 623
Query: 2457 IEDLKMKLVKID 2468
+LK+K + I+
Sbjct: 624 TRELKLKYLIIE 635
Score = 40.0 bits (92), Expect = 0.031
Identities = 34/192 (17%), Positives = 85/192 (44%), Gaps = 16/192 (8%)
Query: 1486 LKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQE 1545
L+EQ+E + E + + + + +S +++L +K+ ++ + E K + +
Sbjct: 461 LQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAMESK 520
Query: 1546 KVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIE 1605
+ + +H + L+ ++ E R +E Q+E+ + +E E++ +LQ E
Sbjct: 521 LLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQE 580
Query: 1606 RDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIET 1665
+ + K++ AK++ + E Q++ E +++ E +N +T
Sbjct: 581 VEVKTKKLKKLYAKLQAVKA------------EIQDQHDEYIRVRQDLE----EAQNEQT 624
Query: 1666 ENIRLTQILHEN 1677
++L ++ EN
Sbjct: 625 RELKLKYLIIEN 636
Score = 39.3 bits (90), Expect = 0.053
Identities = 42/178 (23%), Positives = 80/178 (44%), Gaps = 13/178 (7%)
Query: 1676 ENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQE 1735
E LEE ++ ++ L S E+ +E KE + E + R+ + E L + ++ +
Sbjct: 466 ERLEEEKAAIQDDRSLVSEEKQKLLEE---KEKMLEDLRREQQATELLAAKYKAMES--K 520
Query: 1736 TIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRG 1795
+ R I+ + TNE M + K ++ ++Q+E+ + E + T L+
Sbjct: 521 LLIGGRNIM-DHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQ 579
Query: 1796 IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK 1853
V KT KL + AKLQ E++ + I +++D+ E Q + + +LK
Sbjct: 580 EVEVKTKKLKKLY-------AKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLK 630
Score = 38.1 bits (87), Expect = 0.12
Identities = 56/244 (22%), Positives = 115/244 (47%), Gaps = 48/244 (19%)
Query: 1058 MLESVIAEKEQ------------LKTDLKENIEMTIENQEELRLLGDE--LKKQQEIVAQ 1103
++E+ +AE+E L++ L++N+E ++ Q+E RL ++ ++ + +V++
Sbjct: 426 VIEAWVAEEEDDNNNNHRPPQPILESALEKNMENYLQEQKE-RLEEEKAAIQDDRSLVSE 484
Query: 1104 EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLL----NVQEEMSEMQKKINE 1159
EK ++++ ++ R + E L K + ++ K LL N+ + +E QK +
Sbjct: 485 EKQKLLEEKEKMLEDLRREQQATELLAAKYKAMESK---LLIGGRNIMDHTNEQQKML-- 539
Query: 1160 IENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHL 1219
ELK +E+ E ER E+ Q++ EE + R LQ+ E + L
Sbjct: 540 ------ELKRQEIA-EQKRRER-EMQQEMMLRDEETMEL---RGTYTSLQQEVEVKTKKL 588
Query: 1220 RGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQ 1279
+ +++A K E++ +H E I +R+ + E AQ T++L+ + ++
Sbjct: 589 KKLYAKLQAV----KAEIQ------DQHDEYI-RVRQDLEE--AQNEQTRELKLKYLIIE 635
Query: 1280 EEIP 1283
IP
Sbjct: 636 NFIP 639
Score = 36.2 bits (82), Expect = 0.45
Identities = 32/149 (21%), Positives = 67/149 (44%), Gaps = 8/149 (5%)
Query: 830 EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEM 889
E+K K+ LEE E+M +++ + + + A++++L + + + T E Q+ L
Sbjct: 484 EEKQKL-LEEKEKMLEDLRREQQATELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELK 542
Query: 890 EQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD----DLKQLQESLQIER 945
Q + + R+ +Q +E L E+ + +L QE + LK+L LQ +
Sbjct: 543 RQEIAEQKRREREMQ---QEMMLRDEETMELRGTYTSLQQEVEVKTKKLKKLYAKLQAVK 599
Query: 946 DQLKSDIHDTVNMNIDTQEQLRNALESLK 974
+++ + + + D +E LK
Sbjct: 600 AEIQDQHDEYIRVRQDLEEAQNEQTRELK 628
Score = 34.7 bits (78), Expect = 1.3
Identities = 36/169 (21%), Positives = 77/169 (45%), Gaps = 8/169 (4%)
Query: 1232 QTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQEL 1291
+ KE L+ +++ + + E ++ + E+ +++ E+ T+L E + L
Sbjct: 463 EQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAMESKLL 522
Query: 1292 LPNVKEVSETQETMNELELLTEQ-STTKDSTTLARIEM-----ERLRLNEKFQESQEEIK 1345
+ + T E LEL ++ + K + EM E + L + Q+E++
Sbjct: 523 IGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQEVE 582
Query: 1346 SLTKERDNLKTIKEALEVK-HDQLKEHIRETLAKIQESQSKQEQSLNMK 1393
TK+ L +A++ + DQ E+IR ++E+Q++Q + L +K
Sbjct: 583 VKTKKLKKLYAKLQAVKAEIQDQHDEYIR-VRQDLEEAQNEQTRELKLK 630
Score = 33.9 bits (76), Expect = 2.2
Identities = 47/228 (20%), Positives = 101/228 (44%), Gaps = 32/228 (14%)
Query: 1932 LSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNM 1991
L K + + + +E++ E+ I D D +E QK ++E +K L R ++ +
Sbjct: 453 LEKNMENYLQEQKERLEEEKAAIQD---DRSLVSEEKQKLLEEKEKMLEDLRREQQATEL 509
Query: 1992 SHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESL 2051
K ME K +N+ + + E+ +++ +R E I E
Sbjct: 510 LAAKYKAMES-KLLIGGRNI---------------MDHTNEQQKMLELKRQE---IAEQK 550
Query: 2052 KMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMD 2111
+ ER+ +EM+ RD + +++ L + T+ L++ ++++ + +E+
Sbjct: 551 RREREM----QQEMMLRDEETMELRGTYTSLQQEVEVKTKKLKKLYAKLQAV---KAEIQ 603
Query: 2112 DHYECLNRLSLDLEK-EIEFQKELSMR--VKANLSLPYLQTKHIEKLF 2156
D ++ R+ DLE+ + E +EL ++ + N P + K + +LF
Sbjct: 604 DQHDEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLF 651
>gi|157738629 kinesin family member 13A isoform d [Homo sapiens]
Length = 1749
Score = 242 bits (617), Expect = 4e-63
Identities = 167/440 (37%), Positives = 248/440 (56%), Gaps = 42/440 (9%)
Query: 7 VAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGS---------KSFNFDRVFHG-- 55
V V VRVRP+N RE L V + + V++ + K F FD F
Sbjct: 6 VKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMD 65
Query: 56 -NETTKNVYEEIAAP-----IIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRA 109
+ TTK +E+ I++ A QGYN IFAYGQT SGK+++MMG + LG+IPR
Sbjct: 66 ESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRL 125
Query: 110 IHDIFQKI--KKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADL 167
+F++I ++ + F + VSYMEIYNE + DLL + L +RE YV L
Sbjct: 126 CCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGL 185
Query: 168 TEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVK 227
++ V + E +++G KSR T MN+ SSRSH +F +I+ S G K
Sbjct: 186 SQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGE-K 244
Query: 228 VSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVG----GFINY 283
VS ++LVDLAGSER ++TGAAG RLKEG NIN+SL LG VI L+D G F+ Y
Sbjct: 245 VSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKSKFVPY 304
Query: 284 RDSKLTRILQNSLGGNAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNEVSTD 341
RDS LT +L+++LGGN++T +I TI+P +++ETL+ L++A AK + N VNE +
Sbjct: 305 RDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNE-DPN 363
Query: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401
+++ R+E+ L++QL ++A+AM+ +L + LEE + L I+ LT +
Sbjct: 364 AKVIRELREEVEKLREQL------SQAEAMKAPELKEKLEESEKL-------IKELT--V 408
Query: 402 VTSSSLTLQQELKAKRKRRV 421
L +E+ +R+R++
Sbjct: 409 TWEEKLRKTEEIAQERQRQL 428
Score = 40.0 bits (92), Expect = 0.031
Identities = 97/497 (19%), Positives = 191/497 (38%), Gaps = 46/497 (9%)
Query: 1070 KTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL 1129
+T + I +N EE + + IV NHA+ E ++ L E EKL
Sbjct: 322 QTSMIATISPAADNYEETLSTLRYADRAKRIV----NHAVVNEDPNAKVIRELREEVEKL 377
Query: 1130 KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLN 1189
+E Q Q + + ++E++ E +K I E+ E K E + ER + +
Sbjct: 378 RE--QLSQAEAMKAPELKEKLEESEKLIKELTVTWEEKLRK---TEEIAQERQRQLESMG 432
Query: 1190 ENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE 1249
+ E + K + + L Y+++ G T +++++ I ++
Sbjct: 433 ISLEMSGIKVGDDKCYLVNLNADPALNELLVYYLKDHTRVGADTSQDIQLFGIGIQPQHC 492
Query: 1250 TID-----ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVL----HEEQELLPNVKE--- 1297
ID ++ + E +N L S T+L +L H + LP K
Sbjct: 493 EIDIASDGDVTLTPKENARSCVN-GTLVCSTTQLWHGDRILWGNNHFFRINLPKRKRRDW 551
Query: 1298 ----VSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTK--ER 1351
ET ++L+ +E S+ D E ++ + K S + ++++ + E+
Sbjct: 552 LKDFEKETGPPEHDLDAASEASSEPD----YNYEFAQMEVIMKTLNSNDPVQNVVQVLEK 607
Query: 1352 DNLKTIKEALE---VKHDQLKEHIRETLAKIQESQSKQEQSL--NMKEKDNETTKIVSEM 1406
L+ + ALE + +++ E +R+ L+ ++ QS L + + + T+ E
Sbjct: 608 QYLEEKRSALEEQRLMYERELEQLRQQLSPDRQPQSSGPDRLAYSSQTAQQKVTQWAEER 667
Query: 1407 EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK 1466
++ + A LR ++ R E +A+E L Q LQ + L N K
Sbjct: 668 DELFRQSLAKLREQLVKANTLVR------EANFLAEEMSKLTDYQVTLQIPAANLSANRK 721
Query: 1467 EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ 1526
+ +E ++V Q TI +L L + ++++ +
Sbjct: 722 R---GAIVSEPAIQVRRKGKSTQVWTIEKLENKLIDMRDLYQEWKEKVPEAKRLYGKRGD 778
Query: 1527 EIYEKEEQFNIKQISEV 1543
YE +E N+ ++ V
Sbjct: 779 PFYEAQENHNLIGVANV 795
Score = 33.1 bits (74), Expect = 3.8
Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 15/130 (11%)
Query: 847 IVNLSKEAQKFDSSLGAL------KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
I +S A ++ +L L K +++ + ++E E+E+L+EQL +
Sbjct: 326 IATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAE 385
Query: 901 STLQTVEREKTLITEKL--------QQTLEEVKTLTQEKD-DLKQLQESLQIERDQLKSD 951
+ +EK +EKL ++ L + + + QE+ L+ + SL++ ++ D
Sbjct: 386 AMKAPELKEKLEESEKLIKELTVTWEEKLRKTEEIAQERQRQLESMGISLEMSGIKVGDD 445
Query: 952 IHDTVNMNID 961
VN+N D
Sbjct: 446 KCYLVNLNAD 455
>gi|157738627 kinesin family member 13A isoform c [Homo sapiens]
Length = 1757
Score = 242 bits (617), Expect = 4e-63
Identities = 167/440 (37%), Positives = 248/440 (56%), Gaps = 42/440 (9%)
Query: 7 VAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGS---------KSFNFDRVFHG-- 55
V V VRVRP+N RE L V + + V++ + K F FD F
Sbjct: 6 VKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMD 65
Query: 56 -NETTKNVYEEIAAP-----IIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRA 109
+ TTK +E+ I++ A QGYN IFAYGQT SGK+++MMG + LG+IPR
Sbjct: 66 ESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRL 125
Query: 110 IHDIFQKI--KKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADL 167
+F++I ++ + F + VSYMEIYNE + DLL + L +RE YV L
Sbjct: 126 CCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGL 185
Query: 168 TEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVK 227
++ V + E +++G KSR T MN+ SSRSH +F +I+ S G K
Sbjct: 186 SQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGE-K 244
Query: 228 VSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVG----GFINY 283
VS ++LVDLAGSER ++TGAAG RLKEG NIN+SL LG VI L+D G F+ Y
Sbjct: 245 VSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKSKFVPY 304
Query: 284 RDSKLTRILQNSLGGNAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNEVSTD 341
RDS LT +L+++LGGN++T +I TI+P +++ETL+ L++A AK + N VNE +
Sbjct: 305 RDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNE-DPN 363
Query: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401
+++ R+E+ L++QL ++A+AM+ +L + LEE + L I+ LT +
Sbjct: 364 AKVIRELREEVEKLREQL------SQAEAMKAPELKEKLEESEKL-------IKELT--V 408
Query: 402 VTSSSLTLQQELKAKRKRRV 421
L +E+ +R+R++
Sbjct: 409 TWEEKLRKTEEIAQERQRQL 428
Score = 40.0 bits (92), Expect = 0.031
Identities = 97/497 (19%), Positives = 191/497 (38%), Gaps = 46/497 (9%)
Query: 1070 KTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL 1129
+T + I +N EE + + IV NHA+ E ++ L E EKL
Sbjct: 322 QTSMIATISPAADNYEETLSTLRYADRAKRIV----NHAVVNEDPNAKVIRELREEVEKL 377
Query: 1130 KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLN 1189
+E Q Q + + ++E++ E +K I E+ E K E + ER + +
Sbjct: 378 RE--QLSQAEAMKAPELKEKLEESEKLIKELTVTWEEKLRK---TEEIAQERQRQLESMG 432
Query: 1190 ENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE 1249
+ E + K + + L Y+++ G T +++++ I ++
Sbjct: 433 ISLEMSGIKVGDDKCYLVNLNADPALNELLVYYLKDHTRVGADTSQDIQLFGIGIQPQHC 492
Query: 1250 TID-----ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVL----HEEQELLPNVKE--- 1297
ID ++ + E +N L S T+L +L H + LP K
Sbjct: 493 EIDIASDGDVTLTPKENARSCVN-GTLVCSTTQLWHGDRILWGNNHFFRINLPKRKRRDW 551
Query: 1298 ----VSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTK--ER 1351
ET ++L+ +E S+ D E ++ + K S + ++++ + E+
Sbjct: 552 LKDFEKETGPPEHDLDAASEASSEPD----YNYEFAQMEVIMKTLNSNDPVQNVVQVLEK 607
Query: 1352 DNLKTIKEALE---VKHDQLKEHIRETLAKIQESQSKQEQSL--NMKEKDNETTKIVSEM 1406
L+ + ALE + +++ E +R+ L+ ++ QS L + + + T+ E
Sbjct: 608 QYLEEKRSALEEQRLMYERELEQLRQQLSPDRQPQSSGPDRLAYSSQTAQQKVTQWAEER 667
Query: 1407 EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK 1466
++ + A LR ++ R E +A+E L Q LQ + L N K
Sbjct: 668 DELFRQSLAKLREQLVKANTLVR------EANFLAEEMSKLTDYQVTLQIPAANLSANRK 721
Query: 1467 EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ 1526
+ +E ++V Q TI +L L + ++++ +
Sbjct: 722 R---GAIVSEPAIQVRRKGKSTQVWTIEKLENKLIDMRDLYQEWKEKVPEAKRLYGKRGD 778
Query: 1527 EIYEKEEQFNIKQISEV 1543
YE +E N+ ++ V
Sbjct: 779 PFYEAQENHNLIGVANV 795
Score = 33.1 bits (74), Expect = 3.8
Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 15/130 (11%)
Query: 847 IVNLSKEAQKFDSSLGAL------KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
I +S A ++ +L L K +++ + ++E E+E+L+EQL +
Sbjct: 326 IATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAE 385
Query: 901 STLQTVEREKTLITEKL--------QQTLEEVKTLTQEKD-DLKQLQESLQIERDQLKSD 951
+ +EK +EKL ++ L + + + QE+ L+ + SL++ ++ D
Sbjct: 386 AMKAPELKEKLEESEKLIKELTVTWEEKLRKTEEIAQERQRQLESMGISLEMSGIKVGDD 445
Query: 952 IHDTVNMNID 961
VN+N D
Sbjct: 446 KCYLVNLNAD 455
>gi|157738625 kinesin family member 13A isoform b [Homo sapiens]
Length = 1770
Score = 242 bits (617), Expect = 4e-63
Identities = 167/440 (37%), Positives = 248/440 (56%), Gaps = 42/440 (9%)
Query: 7 VAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGS---------KSFNFDRVFHG-- 55
V V VRVRP+N RE L V + + V++ + K F FD F
Sbjct: 6 VKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMD 65
Query: 56 -NETTKNVYEEIAAP-----IIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRA 109
+ TTK +E+ I++ A QGYN IFAYGQT SGK+++MMG + LG+IPR
Sbjct: 66 ESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRL 125
Query: 110 IHDIFQKI--KKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADL 167
+F++I ++ + F + VSYMEIYNE + DLL + L +RE YV L
Sbjct: 126 CCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGL 185
Query: 168 TEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVK 227
++ V + E +++G KSR T MN+ SSRSH +F +I+ S G K
Sbjct: 186 SQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGE-K 244
Query: 228 VSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVG----GFINY 283
VS ++LVDLAGSER ++TGAAG RLKEG NIN+SL LG VI L+D G F+ Y
Sbjct: 245 VSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKSKFVPY 304
Query: 284 RDSKLTRILQNSLGGNAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNEVSTD 341
RDS LT +L+++LGGN++T +I TI+P +++ETL+ L++A AK + N VNE +
Sbjct: 305 RDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNE-DPN 363
Query: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401
+++ R+E+ L++QL ++A+AM+ +L + LEE + L I+ LT +
Sbjct: 364 AKVIRELREEVEKLREQL------SQAEAMKAPELKEKLEESEKL-------IKELT--V 408
Query: 402 VTSSSLTLQQELKAKRKRRV 421
L +E+ +R+R++
Sbjct: 409 TWEEKLRKTEEIAQERQRQL 428
Score = 40.0 bits (92), Expect = 0.031
Identities = 97/497 (19%), Positives = 191/497 (38%), Gaps = 46/497 (9%)
Query: 1070 KTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL 1129
+T + I +N EE + + IV NHA+ E ++ L E EKL
Sbjct: 322 QTSMIATISPAADNYEETLSTLRYADRAKRIV----NHAVVNEDPNAKVIRELREEVEKL 377
Query: 1130 KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLN 1189
+E Q Q + + ++E++ E +K I E+ E K E + ER + +
Sbjct: 378 RE--QLSQAEAMKAPELKEKLEESEKLIKELTVTWEEKLRK---TEEIAQERQRQLESMG 432
Query: 1190 ENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE 1249
+ E + K + + L Y+++ G T +++++ I ++
Sbjct: 433 ISLEMSGIKVGDDKCYLVNLNADPALNELLVYYLKDHTRVGADTSQDIQLFGIGIQPQHC 492
Query: 1250 TID-----ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVL----HEEQELLPNVKE--- 1297
ID ++ + E +N L S T+L +L H + LP K
Sbjct: 493 EIDIASDGDVTLTPKENARSCVN-GTLVCSTTQLWHGDRILWGNNHFFRINLPKRKRRDW 551
Query: 1298 ----VSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTK--ER 1351
ET ++L+ +E S+ D E ++ + K S + ++++ + E+
Sbjct: 552 LKDFEKETGPPEHDLDAASEASSEPD----YNYEFAQMEVIMKTLNSNDPVQNVVQVLEK 607
Query: 1352 DNLKTIKEALE---VKHDQLKEHIRETLAKIQESQSKQEQSL--NMKEKDNETTKIVSEM 1406
L+ + ALE + +++ E +R+ L+ ++ QS L + + + T+ E
Sbjct: 608 QYLEEKRSALEEQRLMYERELEQLRQQLSPDRQPQSSGPDRLAYSSQTAQQKVTQWAEER 667
Query: 1407 EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK 1466
++ + A LR ++ R E +A+E L Q LQ + L N K
Sbjct: 668 DELFRQSLAKLREQLVKANTLVR------EANFLAEEMSKLTDYQVTLQIPAANLSANRK 721
Query: 1467 EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ 1526
+ +E ++V Q TI +L L + ++++ +
Sbjct: 722 R---GAIVSEPAIQVRRKGKSTQVWTIEKLENKLIDMRDLYQEWKEKVPEAKRLYGKRGD 778
Query: 1527 EIYEKEEQFNIKQISEV 1543
YE +E N+ ++ V
Sbjct: 779 PFYEAQENHNLIGVANV 795
Score = 33.1 bits (74), Expect = 3.8
Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 15/130 (11%)
Query: 847 IVNLSKEAQKFDSSLGAL------KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
I +S A ++ +L L K +++ + ++E E+E+L+EQL +
Sbjct: 326 IATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAE 385
Query: 901 STLQTVEREKTLITEKL--------QQTLEEVKTLTQEKD-DLKQLQESLQIERDQLKSD 951
+ +EK +EKL ++ L + + + QE+ L+ + SL++ ++ D
Sbjct: 386 AMKAPELKEKLEESEKLIKELTVTWEEKLRKTEEIAQERQRQLESMGISLEMSGIKVGDD 445
Query: 952 IHDTVNMNID 961
VN+N D
Sbjct: 446 KCYLVNLNAD 455
>gi|157738621 kinesin family member 13A isoform a [Homo sapiens]
Length = 1805
Score = 242 bits (617), Expect = 4e-63
Identities = 167/440 (37%), Positives = 248/440 (56%), Gaps = 42/440 (9%)
Query: 7 VAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGS---------KSFNFDRVFHG-- 55
V V VRVRP+N RE L V + + V++ + K F FD F
Sbjct: 6 VKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMD 65
Query: 56 -NETTKNVYEEIAAP-----IIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRA 109
+ TTK +E+ I++ A QGYN IFAYGQT SGK+++MMG + LG+IPR
Sbjct: 66 ESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRL 125
Query: 110 IHDIFQKI--KKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADL 167
+F++I ++ + F + VSYMEIYNE + DLL + L +RE YV L
Sbjct: 126 CCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGL 185
Query: 168 TEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVK 227
++ V + E +++G KSR T MN+ SSRSH +F +I+ S G K
Sbjct: 186 SQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGE-K 244
Query: 228 VSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVG----GFINY 283
VS ++LVDLAGSER ++TGAAG RLKEG NIN+SL LG VI L+D G F+ Y
Sbjct: 245 VSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKSKFVPY 304
Query: 284 RDSKLTRILQNSLGGNAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNEVSTD 341
RDS LT +L+++LGGN++T +I TI+P +++ETL+ L++A AK + N VNE +
Sbjct: 305 RDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNE-DPN 363
Query: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401
+++ R+E+ L++QL ++A+AM+ +L + LEE + L I+ LT +
Sbjct: 364 AKVIRELREEVEKLREQL------SQAEAMKAPELKEKLEESEKL-------IKELT--V 408
Query: 402 VTSSSLTLQQELKAKRKRRV 421
L +E+ +R+R++
Sbjct: 409 TWEEKLRKTEEIAQERQRQL 428
Score = 40.0 bits (92), Expect = 0.031
Identities = 97/497 (19%), Positives = 191/497 (38%), Gaps = 46/497 (9%)
Query: 1070 KTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL 1129
+T + I +N EE + + IV NHA+ E ++ L E EKL
Sbjct: 322 QTSMIATISPAADNYEETLSTLRYADRAKRIV----NHAVVNEDPNAKVIRELREEVEKL 377
Query: 1130 KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLN 1189
+E Q Q + + ++E++ E +K I E+ E K E + ER + +
Sbjct: 378 RE--QLSQAEAMKAPELKEKLEESEKLIKELTVTWEEKLRK---TEEIAQERQRQLESMG 432
Query: 1190 ENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE 1249
+ E + K + + L Y+++ G T +++++ I ++
Sbjct: 433 ISLEMSGIKVGDDKCYLVNLNADPALNELLVYYLKDHTRVGADTSQDIQLFGIGIQPQHC 492
Query: 1250 TID-----ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVL----HEEQELLPNVKE--- 1297
ID ++ + E +N L S T+L +L H + LP K
Sbjct: 493 EIDIASDGDVTLTPKENARSCVN-GTLVCSTTQLWHGDRILWGNNHFFRINLPKRKRRDW 551
Query: 1298 ----VSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTK--ER 1351
ET ++L+ +E S+ D E ++ + K S + ++++ + E+
Sbjct: 552 LKDFEKETGPPEHDLDAASEASSEPD----YNYEFAQMEVIMKTLNSNDPVQNVVQVLEK 607
Query: 1352 DNLKTIKEALE---VKHDQLKEHIRETLAKIQESQSKQEQSL--NMKEKDNETTKIVSEM 1406
L+ + ALE + +++ E +R+ L+ ++ QS L + + + T+ E
Sbjct: 608 QYLEEKRSALEEQRLMYERELEQLRQQLSPDRQPQSSGPDRLAYSSQTAQQKVTQWAEER 667
Query: 1407 EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK 1466
++ + A LR ++ R E +A+E L Q LQ + L N K
Sbjct: 668 DELFRQSLAKLREQLVKANTLVR------EANFLAEEMSKLTDYQVTLQIPAANLSANRK 721
Query: 1467 EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ 1526
+ +E ++V Q TI +L L + ++++ +
Sbjct: 722 R---GAIVSEPAIQVRRKGKSTQVWTIEKLENKLIDMRDLYQEWKEKVPEAKRLYGKRGD 778
Query: 1527 EIYEKEEQFNIKQISEV 1543
YE +E N+ ++ V
Sbjct: 779 PFYEAQENHNLIGVANV 795
Score = 33.1 bits (74), Expect = 3.8
Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 15/130 (11%)
Query: 847 IVNLSKEAQKFDSSLGAL------KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
I +S A ++ +L L K +++ + ++E E+E+L+EQL +
Sbjct: 326 IATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAE 385
Query: 901 STLQTVEREKTLITEKL--------QQTLEEVKTLTQEKD-DLKQLQESLQIERDQLKSD 951
+ +EK +EKL ++ L + + + QE+ L+ + SL++ ++ D
Sbjct: 386 AMKAPELKEKLEESEKLIKELTVTWEEKLRKTEEIAQERQRQLESMGISLEMSGIKVGDD 445
Query: 952 IHDTVNMNID 961
VN+N D
Sbjct: 446 KCYLVNLNAD 455
>gi|7661878 kinesin family member 14 [Homo sapiens]
Length = 1648
Score = 237 bits (605), Expect = 1e-61
Identities = 209/741 (28%), Positives = 356/741 (48%), Gaps = 80/741 (10%)
Query: 3 EEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKS----------FNFDRV 52
E V V VRVRP RE+ + + +QV + + + + +K ++FD
Sbjct: 355 ENSQVTVAVRVRPFTKREK-IEKASQVVFMSGKEITVEHPDTKQVYNFIYDVSFWSFDEC 413
Query: 53 FHGNETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHD 112
+ VYE++AAP+++ A +G+N +FAYGQT SGK+YTMMG + G+IPR D
Sbjct: 414 HPHYASQTTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMGFSEEPGIIPRFCED 473
Query: 113 IFQKI--KKFPDREFLLRVSYMEIYNETITDLLC----GTQKMKPLIIREDVNRNVYVAD 166
+F ++ K+ + + + +S+ E+YNE I DLL Q+ +PL +RE YV
Sbjct: 474 LFSQVARKQTQEVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEA 533
Query: 167 LTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSV 226
L+ +V + W+ G K R T MN +SSRSH++F +++ + E
Sbjct: 534 LSMNIVSSYADIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDH 593
Query: 227 KV-SHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSD--GQVGGFINY 283
++ S +NL+DLAGSER + G RLKEG +IN+SL LG+VI LS+ Q FI Y
Sbjct: 594 RITSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPY 653
Query: 284 RDSKLTRILQNSLGGNAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNEVSTD 341
R+S LT +L+ SLGGN+KT +I TI+P + +ETL+ L++A+ A+ + N VNE +
Sbjct: 654 RESVLTWLLKESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNE-DMN 712
Query: 342 EALLKRYRKEIMDLK-KQLEEVSLETRAQAMEKDQLAQL-----LEEKDL--LQKVQNEK 393
L++ + EI LK Q +++ + + ++ L +E+D+ +Q+V EK
Sbjct: 713 AKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEITSLRMKLHQQERDMAEMQRVWKEK 772
Query: 394 IENLTRMLVTSSSLTLQQELKAKRKRRVTWCL-GKINKMKNSNYADQFN-----IPTNIT 447
E + + QE K +K + + + + + N N Q + + T
Sbjct: 773 FEQAEKRKL--------QETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGT 824
Query: 448 TKTHKLSINLLREIDES---VCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLR 504
T K N +I S + + N T+S I A +N ++I E+ LR
Sbjct: 825 TTVGKYKPNSSHDIQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHI-LEITVLR 883
Query: 505 ADYDNLVLDYEQLRTEKEEMEL-KLKEKNDLD--------EFEALERKTKKDQEMQLIHE 555
D ++L + +E+ K K + D +FE + + Q QL E
Sbjct: 884 HG-DRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAKNELLMAQRSQLEAE 942
Query: 556 ISNL-----KNLVKHAEVYNQDLENELSSK----------VELLREKEDQIKKLQEYIDS 600
I + +++ ++ + + ELSS+ +E +E Q KK+QE I++
Sbjct: 943 IKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQE-INN 1001
Query: 601 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT 660
QK + +L + + +E + + + ET+A E +R + ++ L T
Sbjct: 1002 QKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALEDHSIRHARI-----LEALET 1056
Query: 661 TYKQMENDIQLYQSQLEAKKK 681
+++ ++Q+ Q + K
Sbjct: 1057 EKQKIAKEVQILQQNRNNRDK 1077
Score = 42.7 bits (99), Expect = 0.005
Identities = 88/446 (19%), Positives = 179/446 (40%), Gaps = 50/446 (11%)
Query: 784 VVHKESRVQGLLEEI--GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKM-VLEEN 840
+ ++ES + LL+E G +K + T S S +E TL + + + + + N
Sbjct: 651 IPYRESVLTWLLKESLGGNSKTAMIATISPAASNIEE--TLSTLRYANQARLIVNIAKVN 708
Query: 841 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
E MN +++ ++ + + LK E+ R ++ + + Q E
Sbjct: 709 EDMNAKLI------RELKAEIAKLKAAQRNSRNIDPERYRLCRQEITSLRMKLHQQERDM 762
Query: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERD----QLKSDIHDTV 956
+ +Q V +EK EK ++LQE+ ++++ Q+ + + + V
Sbjct: 763 AEMQRVWKEKFEQAEK------------------RKLQETKELQKAGIMFQMDNHLPNLV 804
Query: 957 NMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI- 1015
N+N D Q L +K+ T+ K S ++ + + + T F + I
Sbjct: 805 NLNEDPQLS-EMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLIADDHCTIKNFGGTVSIIP 863
Query: 1016 --DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQ----EKNELQQMLESVIAEKEQL 1069
+ K + K+ +T + +I F +K + ++ I+E +
Sbjct: 864 VGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKD 923
Query: 1070 KTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL 1129
K + M +Q E + +LK ++E++ + I KE + A E K+
Sbjct: 924 FEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM---QGIQIAKEMAQQELSSQKAAYESKI 980
Query: 1130 KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNK-ELTLEHMETERLELAQKL 1188
K +L+E+ Q+ + + KI E+E K L+ + + + +E E L Q L
Sbjct: 981 KALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQAL 1040
Query: 1189 NENYEEVKSI-----TKERKVLKELQ 1209
++ I T+++K+ KE+Q
Sbjct: 1041 EDHSIRHARILEALETEKQKIAKEVQ 1066
Score = 37.7 bits (86), Expect = 0.15
Identities = 82/470 (17%), Positives = 196/470 (41%), Gaps = 64/470 (13%)
Query: 1538 KQISEVQEKVNELKQFKEHRKA------KDSALQSIESKMLELTNRLQESQEEIQIMIKE 1591
K IS + E+ N+ F +R++ K+S + ++ M+ + + EE ++
Sbjct: 635 KVISALSEQANQRSVFIPYRESVLTWLLKESLGGNSKTAMIATISPAASNIEETLSTLRY 694
Query: 1592 KEEMKRVQEALQIERDQLKENTKEI---VAKMKESQE--------------KEYQFLKMT 1634
+ + + ++ D + +E+ +AK+K +Q +E L+M
Sbjct: 695 ANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEITSLRMK 754
Query: 1635 AVNETQEKMCEIEHL-KEQFE-TQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLR 1692
+++ + M E++ + KE+FE +K L+ ET+ ++ I+ + + ++ +D +
Sbjct: 755 -LHQQERDMAEMQRVWKEKFEQAEKRKLQ--ETKELQKAGIMFQMDNHLPNLVNLNEDPQ 811
Query: 1693 SVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEIS 1752
E L + +KE ++++ + + + TI G VS
Sbjct: 812 LSEMLLYM----IKEGTTTVGKYKPNSSHDIQLSGVLIADDHCTIKNFGGTVSIIP---V 864
Query: 1753 NMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGI-VSEKTDKLSNMQKDL 1811
K + L+ L+ + + + H ++ +G S + +S KD
Sbjct: 865 GEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDF 924
Query: 1812 ENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME----QLKKQIKDQSLTLSKLE 1867
E + +L L A QL + ++ E Q K E Q+ K++ Q L+ K
Sbjct: 925 EFAKNEL------LMAQRSQL---EAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAA 975
Query: 1868 IENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELK 1927
E+ ++ +++ ++E ++++E + + ++E + ++QE+
Sbjct: 976 YES---------KIKALEAELREESQRKKMQE---INNQKANHKIEELEKAKQHLEQEIY 1023
Query: 1928 TARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQK 1977
+ + ET+ ++ + + +I+ + I + L+ K ++ K++Q LQ+
Sbjct: 1024 VNK--KRLEMETL-ATKQALEDHSIRHARILEALETEKQKIAKEVQILQQ 1070
Score = 35.4 bits (80), Expect = 0.77
Identities = 43/192 (22%), Positives = 85/192 (44%), Gaps = 20/192 (10%)
Query: 1018 KQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENI 1077
K +L L A++K+ ++ ++ + + K QQ L S +K ++ +K
Sbjct: 928 KNELLMAQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSS---QKAAYESKIKA-- 982
Query: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE-----K 1132
+ E +EE + KK QEI Q+ NH I++ + + ++ V +K E
Sbjct: 983 -LEAELREE-----SQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLAT 1036
Query: 1133 SQQLQEKQQQLLNVQEEM-SEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNEN 1191
Q L++ + + E + +E QK E++ L+ N++ T T + KL+
Sbjct: 1037 KQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWS---SMKLSMM 1093
Query: 1192 YEEVKSITKERK 1203
+E +I+ + K
Sbjct: 1094 IQEANAISSKLK 1105
Score = 34.3 bits (77), Expect = 1.7
Identities = 38/185 (20%), Positives = 76/185 (41%), Gaps = 13/185 (7%)
Query: 1159 EIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDH 1218
+ E KNEL + + +E E E K E + I KE Q+ +++
Sbjct: 923 DFEFAKNELLMAQRS--QLEAEIKEAQLKAKEEMMQGIQIAKEMA-----QQELSSQKAA 975
Query: 1219 LRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI-INTQDLEKSHTK 1277
I+ +EA + + K+ I+ ++ I+EL ++ +I +N + LE
Sbjct: 976 YESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLA 1035
Query: 1278 LQEEIPVLHEEQELLPNVKEVSET--QETMNELELLTEQSTTKDSTTLARIEMERLRLNE 1335
++ L + + E ET Q+ E+++L + +D T + ++L+
Sbjct: 1036 TKQ---ALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSM 1092
Query: 1336 KFQES 1340
QE+
Sbjct: 1093 MIQEA 1097
Score = 34.3 bits (77), Expect = 1.7
Identities = 39/192 (20%), Positives = 89/192 (46%), Gaps = 16/192 (8%)
Query: 850 LSKEAQKFDSSLGALKTELSYKTQ--ELQE-KTREVQERLNEMEQLKEQLE------NRD 900
LS + ++S + AL+ EL ++Q ++QE ++ ++ E+E+ K+ LE +
Sbjct: 969 LSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKR 1028
Query: 901 STLQTVEREKTLITEKLQ--QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNM 958
++T+ ++ L ++ + LE ++T Q+ Q+ + + RD+ + +M
Sbjct: 1029 LEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSM 1088
Query: 959 NIDTQEQLRNALESLKQHQETI--NTLKSKISEEVS---RNLHMEENTGETKDEFQQKMV 1013
+ Q NA+ S + + + K S + S RNL + +T + ++F+ K+
Sbjct: 1089 KLSMMIQEANAISSKLKTYYVFGRHDISDKSSSDTSIRVRNLKLGISTFWSLEKFESKLA 1148
Query: 1014 GIDKKQDLEAKN 1025
+ + + N
Sbjct: 1149 AMKELYESNGSN 1160
Score = 33.9 bits (76), Expect = 2.2
Identities = 95/427 (22%), Positives = 176/427 (41%), Gaps = 69/427 (16%)
Query: 1259 SEKTAQIINTQDLEKSHTKLQEEIPVLH--EEQELLPNVKEVSETQETMNELELLTEQST 1316
+ KTA I + + + ++E + L + L+ N+ +V+E EL E +
Sbjct: 669 NSKTAMIAT---ISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAK 725
Query: 1317 TKDSTTLAR-IEMERLRLNEKFQESQEEIKSLT-----KERDNLKTIKEALEVKHDQLKE 1370
K + +R I+ ER RL ++EI SL +ERD + ++ + K +Q ++
Sbjct: 726 LKAAQRNSRNIDPERYRL------CRQEITSLRMKLHQQERD-MAEMQRVWKEKFEQAEK 778
Query: 1371 HIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSK-R 1429
K+QE++ Q+ + M + DN +V+ E + + L I+ + K +
Sbjct: 779 R------KLQETKELQKAGI-MFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYK 831
Query: 1430 LQESHDEMKSVAKEKDDLQRLQE---------VLQSESDQLKENIKEI-VAKH-----LE 1474
SHD S DD ++ V ++++ ++I EI V +H L
Sbjct: 832 PNSSHDIQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILG 891
Query: 1475 TEEELKVAHCCL------------------KEQEETINELRV-NLSEKETEISTIQKQLE 1515
+ + H K+ E NEL + S+ E EI + QL+
Sbjct: 892 GDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAKNELLMAQRSQLEAEIK--EAQLK 949
Query: 1516 AINDKLQNKIQEIYEKEEQFNIKQISEVQEKVN----ELKQFKEHRKAKDSALQSIESKM 1571
A + +Q IQ E +Q Q + + K+ EL++ + +K ++ Q K+
Sbjct: 950 AKEEMMQG-IQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKI 1008
Query: 1572 LELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKE-NTKEIVAKMKESQEKEYQF 1630
EL Q ++EI + K++ EM+ + +E ++ E + K+ KE Q
Sbjct: 1009 EELEKAKQHLEQEIYVN-KKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQI 1067
Query: 1631 LKMTAVN 1637
L+ N
Sbjct: 1068 LQQNRNN 1074
Score = 32.3 bits (72), Expect = 6.5
Identities = 46/166 (27%), Positives = 78/166 (46%), Gaps = 18/166 (10%)
Query: 1123 AEVEE-KLKEKSQQLQ------EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE 1175
AE++E +LK K + +Q E QQ L+ Q+ E + K E E + + K +
Sbjct: 941 AEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEIN 1000
Query: 1176 HME-TERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTK 1234
+ + ++E +K ++ E+ + K+R ++ L E DH + R +EA L+T
Sbjct: 1001 NQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALE-DHSIRHARILEA--LET- 1056
Query: 1235 EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE 1280
E+ KIA KE Q I + R+ +KT + T K +QE
Sbjct: 1057 EKQKIA----KEVQ--ILQQNRNNRDKTFTVQTTWSSMKLSMMIQE 1096
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.126 0.325
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,302,745
Number of Sequences: 37866
Number of extensions: 4091328
Number of successful extensions: 86876
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 831
Number of HSP's successfully gapped in prelim test: 1786
Number of HSP's that attempted gapping in prelim test: 19812
Number of HSP's gapped (non-prelim): 23792
length of query: 2701
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2581
effective length of database: 13,703,598
effective search space: 35368986438
effective search space used: 35368986438
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.