Guide to the Human Genome
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Search of human proteins with 7019505

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7019505 cytohesin 4 [Homo sapiens]
         (394 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7019505 cytohesin 4 [Homo sapiens]                                 813   0.0  
gi|4758968 cytohesin 3 [Homo sapiens]                                 602   e-172
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     583   e-166
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     580   e-166
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       578   e-165
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       575   e-164
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...   180   2e-45
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...   172   4e-43
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]      146   3e-35
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]       146   3e-35
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   140   3e-33
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]       139   3e-33
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]       139   3e-33
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                 135   5e-32
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]    100   2e-21
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]     99   9e-21
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...    97   3e-20
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...    97   3e-20
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]       97   3e-20
gi|48928044 F-box only protein 8 [Homo sapiens]                        88   2e-17
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...    64   3e-10
gi|24432056 hypothetical protein LOC144717 [Homo sapiens]              55   1e-07
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa...    54   2e-07
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]             53   4e-07
gi|93102364 SWAP-70 protein [Homo sapiens]                             52   7e-07
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ...    52   9e-07
gi|156616273 pleckstrin [Homo sapiens]                                 52   1e-06
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit...    51   2e-06
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H...    50   3e-06
gi|55741447 pleckstrin homology domain containing, family H (wit...    50   4e-06

>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score =  813 bits (2100), Expect = 0.0
 Identities = 394/394 (100%), Positives = 394/394 (100%)

Query: 1   MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ 60
           MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ
Sbjct: 1   MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ 60

Query: 61  KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP 120
           KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP
Sbjct: 61  KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP 120

Query: 121 INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ 180
           INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ
Sbjct: 121 INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ 180

Query: 181 STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240
           STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS
Sbjct: 181 STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240

Query: 241 EPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPR 300
           EPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPR
Sbjct: 241 EPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPR 300

Query: 301 GIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSA 360
           GIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSA
Sbjct: 301 GIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSA 360

Query: 361 EERDQWIESIRASITRVPFYDLVSTRKKKIASKQ 394
           EERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
Sbjct: 361 EERDQWIESIRASITRVPFYDLVSTRKKKIASKQ 394


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  602 bits (1552), Expect = e-172
 Identities = 283/387 (73%), Positives = 338/387 (87%)

Query: 8   PAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCI 67
           P +LS  E EEL  I+  +K+L++DI++LK EIA+V  +ID   S EES+  Q+ K++ +
Sbjct: 13  PEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAM 72

Query: 68  GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQ 127
           GRKKFNMDP KGIQ+ IE+ LL    +D+A+FLYKGEGLNKT IG YLGERD  N++VLQ
Sbjct: 73  GRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQ 132

Query: 128 AFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYV 187
           AFV+ HEFA+LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA+RYCLCNPGVFQSTDTCYV
Sbjct: 133 AFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYV 192

Query: 188 LSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247
           LSF+IIMLNTSLHN NVRD+P  ERF++MNRGIN G DLPE+ LRNL++SIK+EPF IPE
Sbjct: 193 LSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPE 252

Query: 248 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLEN 307
           DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLEN
Sbjct: 253 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLEN 312

Query: 308 LSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWI 367
           LS+++V+DP+KP C ELYNPS +GQ IKACKT+ DGRVVEG H  YRISA S EE+++W+
Sbjct: 313 LSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWM 372

Query: 368 ESIRASITRVPFYDLVSTRKKKIASKQ 394
           +SI+ASI+R PFYD+++TRK++IA+K+
Sbjct: 373 KSIKASISRDPFYDMLATRKRRIANKK 399


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  583 bits (1502), Expect = e-166
 Identities = 270/388 (69%), Positives = 335/388 (86%)

Query: 7   EPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELC 66
           EP +L+  E  EL+ I+  +++LL +IQ+L++E+++  ++++  E+ E S+  Q+ +++ 
Sbjct: 7   EPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMA 66

Query: 67  IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVL 126
           +GRKKFNMDP KGIQ+ +E++LL    ++IARFLYKGEGLNKTAIG YLGER+ +NL VL
Sbjct: 67  MGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVL 126

Query: 127 QAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCY 186
            AFVD HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYCLCNPGVFQSTDTCY
Sbjct: 127 HAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCY 186

Query: 187 VLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIP 246
           VLSF++IMLNTSLHNPNVRD+P  ERFV+MNRGIN G DLPE+ LRNL+DSI++EPF IP
Sbjct: 187 VLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIP 246

Query: 247 EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLE 306
           EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLE
Sbjct: 247 EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE 306

Query: 307 NLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQW 366
           NLS+++VDDP+KP C ELY P+ +GQ IKACKT+ DGRVVEG H  YRISA + EE+D+W
Sbjct: 307 NLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEW 366

Query: 367 IESIRASITRVPFYDLVSTRKKKIASKQ 394
           I+SI+A+++  PFY++++ RKK+I+ K+
Sbjct: 367 IKSIQAAVSVDPFYEMLAARKKRISVKK 394


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  580 bits (1495), Expect = e-166
 Identities = 273/385 (70%), Positives = 330/385 (85%)

Query: 8   PAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCI 67
           P++L++ E +EL+ I+  +++LL DIQ+LKDEIA+V  +I+   S EE +  Q+ K++ +
Sbjct: 9   PSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAM 68

Query: 68  GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQ 127
           GRKKFNMDP KGIQ+ IE+ LL    +DIA+FLYKGEGLNKTAIG YLGERD  N+QVL 
Sbjct: 69  GRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLH 128

Query: 128 AFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYV 187
           AFV+ HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYC CN GVFQSTDTCYV
Sbjct: 129 AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYV 188

Query: 188 LSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247
           LSF+IIMLNTSLHNPNV+D+P  ERF++MNRGIN+G DLPE+ LRNL++SIK+EPF IPE
Sbjct: 189 LSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPE 248

Query: 248 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLEN 307
           DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLEN
Sbjct: 249 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLEN 308

Query: 308 LSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWI 367
           LS+++V+D KKP C ELY P  + Q IKACKT+ DGRVVEG H  YRISA + EE+++WI
Sbjct: 309 LSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWI 368

Query: 368 ESIRASITRVPFYDLVSTRKKKIAS 392
           + I+A+I+R PFY++++ RKKK++S
Sbjct: 369 KCIKAAISRDPFYEMLAARKKKVSS 393


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  578 bits (1490), Expect = e-165
 Identities = 270/389 (69%), Positives = 335/389 (86%), Gaps = 1/389 (0%)

Query: 7   EPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELC 66
           EP +L+  E  EL+ I+  +++LL +IQ+L++E+++  ++++  E+ E S+  Q+ +++ 
Sbjct: 7   EPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMA 66

Query: 67  IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVL 126
           +GRKKFNMDP KGIQ+ +E++LL    ++IARFLYKGEGLNKTAIG YLGER+ +NL VL
Sbjct: 67  MGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVL 126

Query: 127 QAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCY 186
            AFVD HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYCLCNPGVFQSTDTCY
Sbjct: 127 HAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCY 186

Query: 187 VLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIP 246
           VLSF++IMLNTSLHNPNVRD+P  ERFV+MNRGIN G DLPE+ LRNL+DSI++EPF IP
Sbjct: 187 VLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIP 246

Query: 247 EDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPL 305
           EDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPL
Sbjct: 247 EDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPL 306

Query: 306 ENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQ 365
           ENLS+++VDDP+KP C ELY P+ +GQ IKACKT+ DGRVVEG H  YRISA + EE+D+
Sbjct: 307 ENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDE 366

Query: 366 WIESIRASITRVPFYDLVSTRKKKIASKQ 394
           WI+SI+A+++  PFY++++ RKK+I+ K+
Sbjct: 367 WIKSIQAAVSVDPFYEMLAARKKRISVKK 395


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  575 bits (1483), Expect = e-164
 Identities = 273/386 (70%), Positives = 330/386 (85%), Gaps = 1/386 (0%)

Query: 8   PAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCI 67
           P++L++ E +EL+ I+  +++LL DIQ+LKDEIA+V  +I+   S EE +  Q+ K++ +
Sbjct: 9   PSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAM 68

Query: 68  GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQ 127
           GRKKFNMDP KGIQ+ IE+ LL    +DIA+FLYKGEGLNKTAIG YLGERD  N+QVL 
Sbjct: 69  GRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLH 128

Query: 128 AFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYV 187
           AFV+ HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYC CN GVFQSTDTCYV
Sbjct: 129 AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYV 188

Query: 188 LSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247
           LSF+IIMLNTSLHNPNV+D+P  ERF++MNRGIN+G DLPE+ LRNL++SIK+EPF IPE
Sbjct: 189 LSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPE 248

Query: 248 DDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLE 306
           DDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLE
Sbjct: 249 DDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE 308

Query: 307 NLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQW 366
           NLS+++V+D KKP C ELY P  + Q IKACKT+ DGRVVEG H  YRISA + EE+++W
Sbjct: 309 NLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEW 368

Query: 367 IESIRASITRVPFYDLVSTRKKKIAS 392
           I+ I+A+I+R PFY++++ RKKK++S
Sbjct: 369 IKCIKAAISRDPFYEMLAARKKKVSS 394


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score =  180 bits (456), Expect = 2e-45
 Identities = 93/211 (44%), Positives = 136/211 (64%), Gaps = 3/211 (1%)

Query: 40  IADVFAQIDCFESAEESRMAQKEKELCI-GRKKFNMDPAKGIQYFIEHKLLTPDVQDIAR 98
           I     Q+   ++ E+  + +++KE+   G   FN  P +GIQY  E  +L    +DIA+
Sbjct: 676 IGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQ 735

Query: 99  FLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQ 158
           FL++ E L+ T +G +LG+ D  N +V+ A+VD H+F+  + V ALR FL  FRLPGEAQ
Sbjct: 736 FLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795

Query: 159 KIDRMMEAFATRYCLCNPG--VFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSM 216
           KIDR+ME FA RY  CN G  +F S DT YVL++SIIML T LH+P V+++   E+++ M
Sbjct: 796 KIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKM 855

Query: 217 NRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247
           NRGIN+  DLPE+ L  +++ I  +  S+ E
Sbjct: 856 NRGINDSKDLPEEYLSAIYNEIAGKKISMKE 886


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score =  172 bits (437), Expect = 4e-43
 Identities = 88/200 (44%), Positives = 132/200 (66%), Gaps = 3/200 (1%)

Query: 51  ESAEESRMAQKEKELCI-GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKT 109
           +  E+  + +++KE+   G + FN  P +GIQ+  E  +L   V+DIA+FL++ E L+ T
Sbjct: 632 DDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDST 691

Query: 110 AIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAT 169
            +G +LG+    N +V+ A+VD  +F     V ALR FL  FRLPGEAQKIDR+ME FA 
Sbjct: 692 QVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAA 751

Query: 170 RYCLCNPG--VFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLP 227
           RY  CN G  +F S DT YVL++SIIML T LH+P V+++   E+++ MNRGIN+  DLP
Sbjct: 752 RYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLP 811

Query: 228 EDQLRNLFDSIKSEPFSIPE 247
           E+ L ++++ I+ +  ++ E
Sbjct: 812 EEYLSSIYEEIEGKKIAMKE 831


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score =  146 bits (369), Expect = 3e-35
 Identities = 74/194 (38%), Positives = 119/194 (61%), Gaps = 6/194 (3%)

Query: 61  KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP 120
           +++   IG   FN  P KG+QY IE   +      +A FL + +GL++  IG +LG R  
Sbjct: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569

Query: 121 -INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV- 178
             N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+ RYC+CNPGV 
Sbjct: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629

Query: 179 --FQSTDTCYVLSFSIIMLNTSLHNPNVRD--RPPFERFVSMNRGINNGSDLPEDQLRNL 234
             F++ DT ++L+F+II+LNT +++PNV+   +   E F+   RG+++G D+P + L  +
Sbjct: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689

Query: 235 FDSIKSEPFSIPED 248
           ++ I+       ED
Sbjct: 690 YERIRKRELKTNED 703


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score =  146 bits (369), Expect = 3e-35
 Identities = 74/194 (38%), Positives = 119/194 (61%), Gaps = 6/194 (3%)

Query: 61  KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP 120
           +++   IG   FN  P KG+QY IE   +      +A FL + +GL++  IG +LG R  
Sbjct: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583

Query: 121 -INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV- 178
             N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+ RYC+CNPGV 
Sbjct: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643

Query: 179 --FQSTDTCYVLSFSIIMLNTSLHNPNVRD--RPPFERFVSMNRGINNGSDLPEDQLRNL 234
             F++ DT ++L+F+II+LNT +++PNV+   +   E F+   RG+++G D+P + L  +
Sbjct: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703

Query: 235 FDSIKSEPFSIPED 248
           ++ I+       ED
Sbjct: 704 YERIRKRELKTNED 717


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  140 bits (352), Expect = 3e-33
 Identities = 86/236 (36%), Positives = 133/236 (56%), Gaps = 14/236 (5%)

Query: 25  HRKQLLEDIQKLKDEIADV-FAQ----IDCF--ESAEESRMAQKEKELCIGRKKFNMDPA 77
           H K    D+++  D  AD  FA+      C   +  E   +  K+K L  G ++FN  P 
Sbjct: 656 HGKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPK 715

Query: 78  KGIQYFIEHKLLT--PDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEF 135
           KGIQ+  E  LLT   D  ++A++L +   L+K  IG ++ +R   N+ +L++FV    F
Sbjct: 716 KGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDRK--NIDLLESFVSTFSF 773

Query: 136 ANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIML 195
             L L +ALR +L +FRLPGEA  I R++EAF  R+  CN   F ++D C+ L++++IML
Sbjct: 774 QGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACFSLAYAVIML 833

Query: 196 NTSLHNPNVRDR---PPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPED 248
           NT  HN NVR +      E F    +G+N G D  +D L +++ +IK+E   +PE+
Sbjct: 834 NTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEE 889


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score =  139 bits (351), Expect = 3e-33
 Identities = 72/188 (38%), Positives = 116/188 (61%), Gaps = 6/188 (3%)

Query: 67  IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP-INLQV 125
           IG   FN  P KGIQY IE   L+     +A F+ + +GL++  IG +LG R    N  V
Sbjct: 554 IGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDV 613

Query: 126 LQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV---FQST 182
           L   VD  +F++++L  ALR+F    R+ GEAQK++R++EAF+ RYC+CNP +   F++ 
Sbjct: 614 LDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNP 673

Query: 183 DTCYVLSFSIIMLNTSLHNPNVR--DRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240
           DT ++L+F+II+LNT +++P+V+   +   + F+   RG++NG D+P D L  ++  I+ 
Sbjct: 674 DTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQG 733

Query: 241 EPFSIPED 248
                 +D
Sbjct: 734 RELRTNDD 741


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score =  139 bits (351), Expect = 3e-33
 Identities = 72/188 (38%), Positives = 116/188 (61%), Gaps = 6/188 (3%)

Query: 67  IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP-INLQV 125
           IG   FN  P KGIQY IE   L+     +A F+ + +GL++  IG +LG R    N  V
Sbjct: 759 IGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDV 818

Query: 126 LQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV---FQST 182
           L   VD  +F++++L  ALR+F    R+ GEAQK++R++EAF+ RYC+CNP +   F++ 
Sbjct: 819 LDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNP 878

Query: 183 DTCYVLSFSIIMLNTSLHNPNVR--DRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240
           DT ++L+F+II+LNT +++P+V+   +   + F+   RG++NG D+P D L  ++  I+ 
Sbjct: 879 DTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQG 938

Query: 241 EPFSIPED 248
                 +D
Sbjct: 939 RELRTNDD 946


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score =  135 bits (341), Expect = 5e-32
 Identities = 69/188 (36%), Positives = 118/188 (62%), Gaps = 6/188 (3%)

Query: 67  IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGE-RDPINLQV 125
           IG   FN++P KGIQ+ I    +      +A FL + +GL++  IG +LG  +   N  V
Sbjct: 354 IGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDV 413

Query: 126 LQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV---FQST 182
           L   VD  +F+++ L +ALR+F    R+ GEAQK++R++EAF+ RYC+CNP V   F + 
Sbjct: 414 LDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNP 473

Query: 183 DTCYVLSFSIIMLNTSLHNPNVRD--RPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240
           DT ++L+F+II+LNT +++PN++   +   E F+   RG+++G+D+P + +  +++ I+ 
Sbjct: 474 DTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQ 533

Query: 241 EPFSIPED 248
           +     ED
Sbjct: 534 KELKSNED 541


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score =  100 bits (249), Expect = 2e-21
 Identities = 50/157 (31%), Positives = 94/157 (59%), Gaps = 2/157 (1%)

Query: 95  DIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLP 154
           ++A  LY+ EG  K+ +  YL + +  +  V + ++   +F   +L +ALR FL +  L 
Sbjct: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649

Query: 155 GEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFV 214
           GE Q+ +R++  F+ R+  CNPG+F S D+ + L+ +I++LNT LH  N+      + F+
Sbjct: 650 GETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFI 709

Query: 215 SMNRGINNGSDLPEDQLRNLFDSIKSE--PFSIPEDD 249
           +   G+ +G + P++ L+ L+ SI+SE   +++ E+D
Sbjct: 710 TNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEED 746


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score = 98.6 bits (244), Expect = 9e-21
 Identities = 53/156 (33%), Positives = 91/156 (58%), Gaps = 2/156 (1%)

Query: 96  IARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPG 155
           +AR LY  EG  +  +   LG+ +  +  V   ++   +F+ L L  ALR FL +F L G
Sbjct: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376

Query: 156 EAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVS 215
           E Q+ +R++  F+ RYC CNP    S D  + L+ ++++LNT LH  N+  +   ++F++
Sbjct: 377 ETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIA 436

Query: 216 MNRGINNGSDLPEDQLRNLFDSIKSE--PFSIPEDD 249
               +N+G D  +D L+ L++SIK+E   ++I ED+
Sbjct: 437 NLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 48/154 (31%), Positives = 88/154 (57%)

Query: 96  IARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPG 155
           +A+ LY+ +   ++ +  +LG+ +  +  V + ++   +F  + L Q+LR F  +F L G
Sbjct: 54  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113

Query: 156 EAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVS 215
           E Q+ +R++  F+ RY  CNP    S D  + L+ +I++LNT LH  N+  +   + F++
Sbjct: 114 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 173

Query: 216 MNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDD 249
             +G+N G D  +D L+ L++SIK+E      DD
Sbjct: 174 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 207


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
           isoform a [Homo sapiens]
          Length = 1047

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 48/154 (31%), Positives = 88/154 (57%)

Query: 96  IARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPG 155
           +A+ LY+ +   ++ +  +LG+ +  +  V + ++   +F  + L Q+LR F  +F L G
Sbjct: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647

Query: 156 EAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVS 215
           E Q+ +R++  F+ RY  CNP    S D  + L+ +I++LNT LH  N+  +   + F++
Sbjct: 648 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 707

Query: 216 MNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDD 249
             +G+N G D  +D L+ L++SIK+E      DD
Sbjct: 708 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 741


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 50/148 (33%), Positives = 81/148 (54%)

Query: 94  QDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRL 153
           Q +A+ LY+ +G  K  +  +LG+ +  +  V   ++    F  + L QALR FL    L
Sbjct: 559 QRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELAL 618

Query: 154 PGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERF 213
            GE Q+ +R++  F+ RY  CNP    S D  + L+ ++++LNT LH  N+  R     F
Sbjct: 619 MGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDF 678

Query: 214 VSMNRGINNGSDLPEDQLRNLFDSIKSE 241
           +    G+N+G D P + L+ L+ SIK+E
Sbjct: 679 IGNLEGLNDGGDFPRELLKALYSSIKNE 706


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 54/176 (30%), Positives = 91/176 (51%), Gaps = 11/176 (6%)

Query: 68  GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQ 127
           G   FN +P +G+ YF+   +L    ++IA+F++    LN   +  YL ER      VL 
Sbjct: 142 GSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDER----RDVLD 197

Query: 128 AFVDCHEFANLNLVQALRQFLWSFRLPGE-AQKIDRMMEAFATRYCLCNPGVFQ----ST 182
             V  H F N  L  ALR+F      P E  + ++ ++  F+ R+C CNP + +    S 
Sbjct: 198 DLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSP 257

Query: 183 DTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSI 238
           D  YVL +S+I+L+  L +P+V+++     F+   R      ++ ED + +L+D+I
Sbjct: 258 DAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHLYDNI 311


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 10/111 (9%)

Query: 264 GWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLE 323
           GWL K GG VKTW  RWF+L  + LYYF+   + +P G I L    V +        C E
Sbjct: 24  GWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHP------CNE 77

Query: 324 LYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASI 374
             NP   G+ +      GD   +   HESY + A++  + + W++SIR  I
Sbjct: 78  -ENP---GKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVI 124


>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
          Length = 249

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 25/54 (46%), Positives = 34/54 (62%)

Query: 261 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVD 314
           D  G+L K GGR   + RRWF+L  N L+YFE    +EP G+I LE  +V+ V+
Sbjct: 19  DNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGVIILEGCTVELVE 72


>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
           sapiens]
          Length = 631

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 34/113 (30%), Positives = 54/113 (47%), Gaps = 20/113 (17%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFC 321
           ++G+L K G   + W  RWF L  +CL YF     KE RGIIPL+              C
Sbjct: 219 KQGYLWKRGHLRRNWAERWFQLQPSCLCYFGSEECKEKRGIIPLD-----------AHCC 267

Query: 322 LELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASI 374
           +E+  P   G++   C        V+  + +Y +SA+   +R +W  +I+ +I
Sbjct: 268 VEVL-PDRDGKRCMFC--------VKTANRTYEMSASDTRQRQEWTAAIQMAI 311


>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
          Length = 698

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 32/117 (27%), Positives = 58/117 (49%), Gaps = 16/117 (13%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKV----DDPK 317
           + GWL K    +K W++RWF+L  + L+Y++   + +P+G I L+   V ++    +DP 
Sbjct: 40  KAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPG 99

Query: 318 KPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASI 374
           K     L+  S  G         G+   V    E+  + A+S  + + W+++IR  I
Sbjct: 100 K----HLFEISPGGA--------GEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 144


>gi|93102364 SWAP-70 protein [Homo sapiens]
          Length = 585

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 36/139 (25%), Positives = 66/139 (47%), Gaps = 27/139 (19%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPL-ENLSVQKVDDPKKPF 320
           ++G+++K G R K W  RWF+L  N + Y+     K+ +G I L EN  V+ + D     
Sbjct: 213 KQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKK 272

Query: 321 CLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRV--- 377
           CL L                     V+   +++ ISA+  +++ +WI++I ++I  +   
Sbjct: 273 CLFL---------------------VKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLG 311

Query: 378 --PFYDLVSTRKKKIASKQ 394
             P +     R+K++  KQ
Sbjct: 312 SPPPHKEARQRRKELRKKQ 330


>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
           sapiens]
          Length = 1048

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 35/119 (29%), Positives = 55/119 (46%), Gaps = 20/119 (16%)

Query: 262 REGWLLKLGGR-VKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPF 320
           + GWL K     VK W +RWF+L D CL+Y++   ++   G IPL +  V  V       
Sbjct: 62  KAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAV------- 114

Query: 321 CLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESI-RASITRVP 378
                 PS    +    K +  G        +Y  SA S EE++ WI+++  A+  ++P
Sbjct: 115 -----QPSDNISRKHTFKAEHAG------VRTYFFSAESPEEQEAWIQAMGEAARVQIP 162


>gi|156616273 pleckstrin [Homo sapiens]
          Length = 350

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 30/113 (26%), Positives = 54/113 (47%), Gaps = 19/113 (16%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFC 321
           REG+L+K G    TWK  W +L ++ + +++  +D  P+G+IPL+      +  P + F 
Sbjct: 7   REGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKG---STLTSPCQDF- 62

Query: 322 LELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASI 374
                    G+++   K      +   K + +   A   EERD W+  I+ +I
Sbjct: 63  ---------GKRMFVFK------ITTTKQQDHFFQAAFLEERDAWVRDIKKAI 100



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 30/112 (26%), Positives = 52/112 (46%), Gaps = 17/112 (15%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDN--CLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKP 319
           ++G LLK G R K WK R FIL ++   L+Y++    ++P G I L    V  V+     
Sbjct: 247 KQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVES---- 302

Query: 320 FCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIR 371
                   +  G+K    + +    ++      Y + A + +ER +WI +I+
Sbjct: 303 --------NSNGRK---SEEENLFEIITADEVHYFLQAATPKERTEWIRAIQ 343


>gi|158631203 dual adaptor of phosphotyrosine and
           3-phosphoinositides [Homo sapiens]
          Length = 280

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 21/116 (18%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFC 321
           +EG+L K GG VKTWK RWF L  N L YF+     EP  I+ L   S  + D     + 
Sbjct: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFD-----YS 221

Query: 322 LELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRV 377
            E  N  C                +     ++ + A +  E D+WI+ +R  ++++
Sbjct: 222 QERVNCFC----------------LVFPFRTFYLCAKTGVEADEWIKILRWKLSQI 261


>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
           sapiens]
          Length = 713

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 24/69 (34%), Positives = 38/69 (55%), Gaps = 4/69 (5%)

Query: 260 PDREGWLLKL----GGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDD 315
           PD +GWLL      G     W+RRWF+L  + LY++    D++  G+I + N S++   D
Sbjct: 397 PDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHD 456

Query: 316 PKKPFCLEL 324
            KK +  +L
Sbjct: 457 QKKKYVFQL 465


>gi|55741447 pleckstrin homology domain containing, family H (with
           MyTH4 domain) member 1 [Homo sapiens]
          Length = 1364

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 20/49 (40%), Positives = 35/49 (71%), Gaps = 2/49 (4%)

Query: 261 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTD--KEPRGIIPLEN 307
           ++ G+LLK+G +VKTWKRRWF+L    + Y++  +D  ++P+G + L +
Sbjct: 580 EKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNS 628



 Score = 33.9 bits (76), Expect = 0.26
 Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 4/56 (7%)

Query: 260 PDREGWLLKLG-GRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVD 314
           P  +GWL K+  G  K     W  L     YY+    DK P G +P+ +  +++VD
Sbjct: 688 PTVKGWLTKVKHGHSKVV---WCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVD 740


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,534,128
Number of Sequences: 37866
Number of extensions: 706962
Number of successful extensions: 2253
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 116
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 2033
Number of HSP's gapped (non-prelim): 218
length of query: 394
length of database: 18,247,518
effective HSP length: 104
effective length of query: 290
effective length of database: 14,309,454
effective search space: 4149741660
effective search space used: 4149741660
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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