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Search of human proteins with 7019505
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7019505 cytohesin 4 [Homo sapiens]
(394 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7019505 cytohesin 4 [Homo sapiens] 813 0.0
gi|4758968 cytohesin 3 [Homo sapiens] 602 e-172
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 583 e-166
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 580 e-166
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 578 e-165
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 575 e-164
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr... 180 2e-45
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange... 172 4e-43
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens] 146 3e-35
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens] 146 3e-35
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti... 140 3e-33
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens] 139 3e-33
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens] 139 3e-33
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens] 135 5e-32
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens] 100 2e-21
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens] 99 9e-21
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ... 97 3e-20
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6... 97 3e-20
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens] 97 3e-20
gi|48928044 F-box only protein 8 [Homo sapiens] 88 2e-17
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 64 3e-10
gi|24432056 hypothetical protein LOC144717 [Homo sapiens] 55 1e-07
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 54 2e-07
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 53 4e-07
gi|93102364 SWAP-70 protein [Homo sapiens] 52 7e-07
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 52 9e-07
gi|156616273 pleckstrin [Homo sapiens] 52 1e-06
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 51 2e-06
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H... 50 3e-06
gi|55741447 pleckstrin homology domain containing, family H (wit... 50 4e-06
>gi|7019505 cytohesin 4 [Homo sapiens]
Length = 394
Score = 813 bits (2100), Expect = 0.0
Identities = 394/394 (100%), Positives = 394/394 (100%)
Query: 1 MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ 60
MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ
Sbjct: 1 MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ 60
Query: 61 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP 120
KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP
Sbjct: 61 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP 120
Query: 121 INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ 180
INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ
Sbjct: 121 INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ 180
Query: 181 STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240
STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS
Sbjct: 181 STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240
Query: 241 EPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPR 300
EPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPR
Sbjct: 241 EPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPR 300
Query: 301 GIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSA 360
GIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSA
Sbjct: 301 GIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSA 360
Query: 361 EERDQWIESIRASITRVPFYDLVSTRKKKIASKQ 394
EERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
Sbjct: 361 EERDQWIESIRASITRVPFYDLVSTRKKKIASKQ 394
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 602 bits (1552), Expect = e-172
Identities = 283/387 (73%), Positives = 338/387 (87%)
Query: 8 PAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCI 67
P +LS E EEL I+ +K+L++DI++LK EIA+V +ID S EES+ Q+ K++ +
Sbjct: 13 PEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAM 72
Query: 68 GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQ 127
GRKKFNMDP KGIQ+ IE+ LL +D+A+FLYKGEGLNKT IG YLGERD N++VLQ
Sbjct: 73 GRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQ 132
Query: 128 AFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYV 187
AFV+ HEFA+LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA+RYCLCNPGVFQSTDTCYV
Sbjct: 133 AFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYV 192
Query: 188 LSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247
LSF+IIMLNTSLHN NVRD+P ERF++MNRGIN G DLPE+ LRNL++SIK+EPF IPE
Sbjct: 193 LSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPE 252
Query: 248 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLEN 307
DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLEN
Sbjct: 253 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLEN 312
Query: 308 LSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWI 367
LS+++V+DP+KP C ELYNPS +GQ IKACKT+ DGRVVEG H YRISA S EE+++W+
Sbjct: 313 LSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWM 372
Query: 368 ESIRASITRVPFYDLVSTRKKKIASKQ 394
+SI+ASI+R PFYD+++TRK++IA+K+
Sbjct: 373 KSIKASISRDPFYDMLATRKRRIANKK 399
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 583 bits (1502), Expect = e-166
Identities = 270/388 (69%), Positives = 335/388 (86%)
Query: 7 EPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELC 66
EP +L+ E EL+ I+ +++LL +IQ+L++E+++ ++++ E+ E S+ Q+ +++
Sbjct: 7 EPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMA 66
Query: 67 IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVL 126
+GRKKFNMDP KGIQ+ +E++LL ++IARFLYKGEGLNKTAIG YLGER+ +NL VL
Sbjct: 67 MGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVL 126
Query: 127 QAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCY 186
AFVD HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYCLCNPGVFQSTDTCY
Sbjct: 127 HAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCY 186
Query: 187 VLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIP 246
VLSF++IMLNTSLHNPNVRD+P ERFV+MNRGIN G DLPE+ LRNL+DSI++EPF IP
Sbjct: 187 VLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIP 246
Query: 247 EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLE 306
EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLE
Sbjct: 247 EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE 306
Query: 307 NLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQW 366
NLS+++VDDP+KP C ELY P+ +GQ IKACKT+ DGRVVEG H YRISA + EE+D+W
Sbjct: 307 NLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEW 366
Query: 367 IESIRASITRVPFYDLVSTRKKKIASKQ 394
I+SI+A+++ PFY++++ RKK+I+ K+
Sbjct: 367 IKSIQAAVSVDPFYEMLAARKKRISVKK 394
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 580 bits (1495), Expect = e-166
Identities = 273/385 (70%), Positives = 330/385 (85%)
Query: 8 PAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCI 67
P++L++ E +EL+ I+ +++LL DIQ+LKDEIA+V +I+ S EE + Q+ K++ +
Sbjct: 9 PSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAM 68
Query: 68 GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQ 127
GRKKFNMDP KGIQ+ IE+ LL +DIA+FLYKGEGLNKTAIG YLGERD N+QVL
Sbjct: 69 GRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLH 128
Query: 128 AFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYV 187
AFV+ HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYC CN GVFQSTDTCYV
Sbjct: 129 AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYV 188
Query: 188 LSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247
LSF+IIMLNTSLHNPNV+D+P ERF++MNRGIN+G DLPE+ LRNL++SIK+EPF IPE
Sbjct: 189 LSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPE 248
Query: 248 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLEN 307
DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLEN
Sbjct: 249 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLEN 308
Query: 308 LSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWI 367
LS+++V+D KKP C ELY P + Q IKACKT+ DGRVVEG H YRISA + EE+++WI
Sbjct: 309 LSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWI 368
Query: 368 ESIRASITRVPFYDLVSTRKKKIAS 392
+ I+A+I+R PFY++++ RKKK++S
Sbjct: 369 KCIKAAISRDPFYEMLAARKKKVSS 393
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 578 bits (1490), Expect = e-165
Identities = 270/389 (69%), Positives = 335/389 (86%), Gaps = 1/389 (0%)
Query: 7 EPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELC 66
EP +L+ E EL+ I+ +++LL +IQ+L++E+++ ++++ E+ E S+ Q+ +++
Sbjct: 7 EPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMA 66
Query: 67 IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVL 126
+GRKKFNMDP KGIQ+ +E++LL ++IARFLYKGEGLNKTAIG YLGER+ +NL VL
Sbjct: 67 MGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVL 126
Query: 127 QAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCY 186
AFVD HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYCLCNPGVFQSTDTCY
Sbjct: 127 HAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCY 186
Query: 187 VLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIP 246
VLSF++IMLNTSLHNPNVRD+P ERFV+MNRGIN G DLPE+ LRNL+DSI++EPF IP
Sbjct: 187 VLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIP 246
Query: 247 EDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPL 305
EDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPL
Sbjct: 247 EDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPL 306
Query: 306 ENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQ 365
ENLS+++VDDP+KP C ELY P+ +GQ IKACKT+ DGRVVEG H YRISA + EE+D+
Sbjct: 307 ENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDE 366
Query: 366 WIESIRASITRVPFYDLVSTRKKKIASKQ 394
WI+SI+A+++ PFY++++ RKK+I+ K+
Sbjct: 367 WIKSIQAAVSVDPFYEMLAARKKRISVKK 395
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 575 bits (1483), Expect = e-164
Identities = 273/386 (70%), Positives = 330/386 (85%), Gaps = 1/386 (0%)
Query: 8 PAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCI 67
P++L++ E +EL+ I+ +++LL DIQ+LKDEIA+V +I+ S EE + Q+ K++ +
Sbjct: 9 PSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAM 68
Query: 68 GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQ 127
GRKKFNMDP KGIQ+ IE+ LL +DIA+FLYKGEGLNKTAIG YLGERD N+QVL
Sbjct: 69 GRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLH 128
Query: 128 AFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYV 187
AFV+ HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYC CN GVFQSTDTCYV
Sbjct: 129 AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYV 188
Query: 188 LSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247
LSF+IIMLNTSLHNPNV+D+P ERF++MNRGIN+G DLPE+ LRNL++SIK+EPF IPE
Sbjct: 189 LSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPE 248
Query: 248 DDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLE 306
DDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLE
Sbjct: 249 DDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE 308
Query: 307 NLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQW 366
NLS+++V+D KKP C ELY P + Q IKACKT+ DGRVVEG H YRISA + EE+++W
Sbjct: 309 NLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEW 368
Query: 367 IESIRASITRVPFYDLVSTRKKKIAS 392
I+ I+A+I+R PFY++++ RKKK++S
Sbjct: 369 IKCIKAAISRDPFYEMLAARKKKVSS 394
>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
protein 1 [Homo sapiens]
Length = 1849
Score = 180 bits (456), Expect = 2e-45
Identities = 93/211 (44%), Positives = 136/211 (64%), Gaps = 3/211 (1%)
Query: 40 IADVFAQIDCFESAEESRMAQKEKELCI-GRKKFNMDPAKGIQYFIEHKLLTPDVQDIAR 98
I Q+ ++ E+ + +++KE+ G FN P +GIQY E +L +DIA+
Sbjct: 676 IGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQ 735
Query: 99 FLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQ 158
FL++ E L+ T +G +LG+ D N +V+ A+VD H+F+ + V ALR FL FRLPGEAQ
Sbjct: 736 FLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795
Query: 159 KIDRMMEAFATRYCLCNPG--VFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSM 216
KIDR+ME FA RY CN G +F S DT YVL++SIIML T LH+P V+++ E+++ M
Sbjct: 796 KIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKM 855
Query: 217 NRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247
NRGIN+ DLPE+ L +++ I + S+ E
Sbjct: 856 NRGINDSKDLPEEYLSAIYNEIAGKKISMKE 886
>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
factor 2 [Homo sapiens]
Length = 1785
Score = 172 bits (437), Expect = 4e-43
Identities = 88/200 (44%), Positives = 132/200 (66%), Gaps = 3/200 (1%)
Query: 51 ESAEESRMAQKEKELCI-GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKT 109
+ E+ + +++KE+ G + FN P +GIQ+ E +L V+DIA+FL++ E L+ T
Sbjct: 632 DDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDST 691
Query: 110 AIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAT 169
+G +LG+ N +V+ A+VD +F V ALR FL FRLPGEAQKIDR+ME FA
Sbjct: 692 QVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAA 751
Query: 170 RYCLCNPG--VFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLP 227
RY CN G +F S DT YVL++SIIML T LH+P V+++ E+++ MNRGIN+ DLP
Sbjct: 752 RYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLP 811
Query: 228 EDQLRNLFDSIKSEPFSIPE 247
E+ L ++++ I+ + ++ E
Sbjct: 812 EEYLSSIYEEIEGKKIAMKE 831
>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
Length = 1114
Score = 146 bits (369), Expect = 3e-35
Identities = 74/194 (38%), Positives = 119/194 (61%), Gaps = 6/194 (3%)
Query: 61 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP 120
+++ IG FN P KG+QY IE + +A FL + +GL++ IG +LG R
Sbjct: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569
Query: 121 -INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV- 178
N VL VD +F+ + L +ALR+F R+ GEAQK++R++EAF+ RYC+CNPGV
Sbjct: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629
Query: 179 --FQSTDTCYVLSFSIIMLNTSLHNPNVRD--RPPFERFVSMNRGINNGSDLPEDQLRNL 234
F++ DT ++L+F+II+LNT +++PNV+ + E F+ RG+++G D+P + L +
Sbjct: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689
Query: 235 FDSIKSEPFSIPED 248
++ I+ ED
Sbjct: 690 YERIRKRELKTNED 703
>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
Length = 963
Score = 146 bits (369), Expect = 3e-35
Identities = 74/194 (38%), Positives = 119/194 (61%), Gaps = 6/194 (3%)
Query: 61 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP 120
+++ IG FN P KG+QY IE + +A FL + +GL++ IG +LG R
Sbjct: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583
Query: 121 -INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV- 178
N VL VD +F+ + L +ALR+F R+ GEAQK++R++EAF+ RYC+CNPGV
Sbjct: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643
Query: 179 --FQSTDTCYVLSFSIIMLNTSLHNPNVRD--RPPFERFVSMNRGINNGSDLPEDQLRNL 234
F++ DT ++L+F+II+LNT +++PNV+ + E F+ RG+++G D+P + L +
Sbjct: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703
Query: 235 FDSIKSEPFSIPED 248
++ I+ ED
Sbjct: 704 YERIRKRELKTNED 717
>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
exchange factor 1 [Homo sapiens]
Length = 1859
Score = 140 bits (352), Expect = 3e-33
Identities = 86/236 (36%), Positives = 133/236 (56%), Gaps = 14/236 (5%)
Query: 25 HRKQLLEDIQKLKDEIADV-FAQ----IDCF--ESAEESRMAQKEKELCIGRKKFNMDPA 77
H K D+++ D AD FA+ C + E + K+K L G ++FN P
Sbjct: 656 HGKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPK 715
Query: 78 KGIQYFIEHKLLT--PDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEF 135
KGIQ+ E LLT D ++A++L + L+K IG ++ +R N+ +L++FV F
Sbjct: 716 KGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDRK--NIDLLESFVSTFSF 773
Query: 136 ANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIML 195
L L +ALR +L +FRLPGEA I R++EAF R+ CN F ++D C+ L++++IML
Sbjct: 774 QGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACFSLAYAVIML 833
Query: 196 NTSLHNPNVRDR---PPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPED 248
NT HN NVR + E F +G+N G D +D L +++ +IK+E +PE+
Sbjct: 834 NTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEE 889
>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
Length = 949
Score = 139 bits (351), Expect = 3e-33
Identities = 72/188 (38%), Positives = 116/188 (61%), Gaps = 6/188 (3%)
Query: 67 IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP-INLQV 125
IG FN P KGIQY IE L+ +A F+ + +GL++ IG +LG R N V
Sbjct: 554 IGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDV 613
Query: 126 LQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV---FQST 182
L VD +F++++L ALR+F R+ GEAQK++R++EAF+ RYC+CNP + F++
Sbjct: 614 LDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNP 673
Query: 183 DTCYVLSFSIIMLNTSLHNPNVR--DRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240
DT ++L+F+II+LNT +++P+V+ + + F+ RG++NG D+P D L ++ I+
Sbjct: 674 DTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQG 733
Query: 241 EPFSIPED 248
+D
Sbjct: 734 RELRTNDD 741
>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
Length = 1488
Score = 139 bits (351), Expect = 3e-33
Identities = 72/188 (38%), Positives = 116/188 (61%), Gaps = 6/188 (3%)
Query: 67 IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP-INLQV 125
IG FN P KGIQY IE L+ +A F+ + +GL++ IG +LG R N V
Sbjct: 759 IGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDV 818
Query: 126 LQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV---FQST 182
L VD +F++++L ALR+F R+ GEAQK++R++EAF+ RYC+CNP + F++
Sbjct: 819 LDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNP 878
Query: 183 DTCYVLSFSIIMLNTSLHNPNVR--DRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240
DT ++L+F+II+LNT +++P+V+ + + F+ RG++NG D+P D L ++ I+
Sbjct: 879 DTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQG 938
Query: 241 EPFSIPED 248
+D
Sbjct: 939 RELRTNDD 946
>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
Length = 759
Score = 135 bits (341), Expect = 5e-32
Identities = 69/188 (36%), Positives = 118/188 (62%), Gaps = 6/188 (3%)
Query: 67 IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGE-RDPINLQV 125
IG FN++P KGIQ+ I + +A FL + +GL++ IG +LG + N V
Sbjct: 354 IGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDV 413
Query: 126 LQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGV---FQST 182
L VD +F+++ L +ALR+F R+ GEAQK++R++EAF+ RYC+CNP V F +
Sbjct: 414 LDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNP 473
Query: 183 DTCYVLSFSIIMLNTSLHNPNVRD--RPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS 240
DT ++L+F+II+LNT +++PN++ + E F+ RG+++G+D+P + + +++ I+
Sbjct: 474 DTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQ 533
Query: 241 EPFSIPED 248
+ ED
Sbjct: 534 KELKSNED 541
>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
Length = 1056
Score = 100 bits (249), Expect = 2e-21
Identities = 50/157 (31%), Positives = 94/157 (59%), Gaps = 2/157 (1%)
Query: 95 DIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLP 154
++A LY+ EG K+ + YL + + + V + ++ +F +L +ALR FL + L
Sbjct: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
Query: 155 GEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFV 214
GE Q+ +R++ F+ R+ CNPG+F S D+ + L+ +I++LNT LH N+ + F+
Sbjct: 650 GETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFI 709
Query: 215 SMNRGINNGSDLPEDQLRNLFDSIKSE--PFSIPEDD 249
+ G+ +G + P++ L+ L+ SI+SE +++ E+D
Sbjct: 710 TNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEED 746
>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
Length = 771
Score = 98.6 bits (244), Expect = 9e-21
Identities = 53/156 (33%), Positives = 91/156 (58%), Gaps = 2/156 (1%)
Query: 96 IARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPG 155
+AR LY EG + + LG+ + + V ++ +F+ L L ALR FL +F L G
Sbjct: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376
Query: 156 EAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVS 215
E Q+ +R++ F+ RYC CNP S D + L+ ++++LNT LH N+ + ++F++
Sbjct: 377 ETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIA 436
Query: 216 MNRGINNGSDLPEDQLRNLFDSIKSE--PFSIPEDD 249
+N+G D +D L+ L++SIK+E ++I ED+
Sbjct: 437 NLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472
>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
isoform b [Homo sapiens]
Length = 513
Score = 97.1 bits (240), Expect = 3e-20
Identities = 48/154 (31%), Positives = 88/154 (57%)
Query: 96 IARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPG 155
+A+ LY+ + ++ + +LG+ + + V + ++ +F + L Q+LR F +F L G
Sbjct: 54 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113
Query: 156 EAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVS 215
E Q+ +R++ F+ RY CNP S D + L+ +I++LNT LH N+ + + F++
Sbjct: 114 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 173
Query: 216 MNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDD 249
+G+N G D +D L+ L++SIK+E DD
Sbjct: 174 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 207
>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
isoform a [Homo sapiens]
Length = 1047
Score = 97.1 bits (240), Expect = 3e-20
Identities = 48/154 (31%), Positives = 88/154 (57%)
Query: 96 IARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPG 155
+A+ LY+ + ++ + +LG+ + + V + ++ +F + L Q+LR F +F L G
Sbjct: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647
Query: 156 EAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVS 215
E Q+ +R++ F+ RY CNP S D + L+ +I++LNT LH N+ + + F++
Sbjct: 648 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 707
Query: 216 MNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDD 249
+G+N G D +D L+ L++SIK+E DD
Sbjct: 708 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 741
>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
Length = 1024
Score = 96.7 bits (239), Expect = 3e-20
Identities = 50/148 (33%), Positives = 81/148 (54%)
Query: 94 QDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRL 153
Q +A+ LY+ +G K + +LG+ + + V ++ F + L QALR FL L
Sbjct: 559 QRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELAL 618
Query: 154 PGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERF 213
GE Q+ +R++ F+ RY CNP S D + L+ ++++LNT LH N+ R F
Sbjct: 619 MGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDF 678
Query: 214 VSMNRGINNGSDLPEDQLRNLFDSIKSE 241
+ G+N+G D P + L+ L+ SIK+E
Sbjct: 679 IGNLEGLNDGGDFPRELLKALYSSIKNE 706
>gi|48928044 F-box only protein 8 [Homo sapiens]
Length = 319
Score = 87.8 bits (216), Expect = 2e-17
Identities = 54/176 (30%), Positives = 91/176 (51%), Gaps = 11/176 (6%)
Query: 68 GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQ 127
G FN +P +G+ YF+ +L ++IA+F++ LN + YL ER VL
Sbjct: 142 GSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDER----RDVLD 197
Query: 128 AFVDCHEFANLNLVQALRQFLWSFRLPGE-AQKIDRMMEAFATRYCLCNPGVFQ----ST 182
V H F N L ALR+F P E + ++ ++ F+ R+C CNP + + S
Sbjct: 198 DLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSP 257
Query: 183 DTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSI 238
D YVL +S+I+L+ L +P+V+++ F+ R ++ ED + +L+D+I
Sbjct: 258 DAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHLYDNI 311
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 63.5 bits (153), Expect = 3e-10
Identities = 40/111 (36%), Positives = 56/111 (50%), Gaps = 10/111 (9%)
Query: 264 GWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLE 323
GWL K GG VKTW RWF+L + LYYF+ + +P G I L V + C E
Sbjct: 24 GWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHP------CNE 77
Query: 324 LYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASI 374
NP G+ + GD + HESY + A++ + + W++SIR I
Sbjct: 78 -ENP---GKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVI 124
>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
Length = 249
Score = 55.1 bits (131), Expect = 1e-07
Identities = 25/54 (46%), Positives = 34/54 (62%)
Query: 261 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVD 314
D G+L K GGR + RRWF+L N L+YFE +EP G+I LE +V+ V+
Sbjct: 19 DNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGVIILEGCTVELVE 72
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 53.9 bits (128), Expect = 2e-07
Identities = 34/113 (30%), Positives = 54/113 (47%), Gaps = 20/113 (17%)
Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFC 321
++G+L K G + W RWF L +CL YF KE RGIIPL+ C
Sbjct: 219 KQGYLWKRGHLRRNWAERWFQLQPSCLCYFGSEECKEKRGIIPLD-----------AHCC 267
Query: 322 LELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASI 374
+E+ P G++ C V+ + +Y +SA+ +R +W +I+ +I
Sbjct: 268 VEVL-PDRDGKRCMFC--------VKTANRTYEMSASDTRQRQEWTAAIQMAI 311
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 53.1 bits (126), Expect = 4e-07
Identities = 32/117 (27%), Positives = 58/117 (49%), Gaps = 16/117 (13%)
Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKV----DDPK 317
+ GWL K +K W++RWF+L + L+Y++ + +P+G I L+ V ++ +DP
Sbjct: 40 KAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPG 99
Query: 318 KPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASI 374
K L+ S G G+ V E+ + A+S + + W+++IR I
Sbjct: 100 K----HLFEISPGGA--------GEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 144
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 52.4 bits (124), Expect = 7e-07
Identities = 36/139 (25%), Positives = 66/139 (47%), Gaps = 27/139 (19%)
Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPL-ENLSVQKVDDPKKPF 320
++G+++K G R K W RWF+L N + Y+ K+ +G I L EN V+ + D
Sbjct: 213 KQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKK 272
Query: 321 CLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRV--- 377
CL L V+ +++ ISA+ +++ +WI++I ++I +
Sbjct: 273 CLFL---------------------VKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLG 311
Query: 378 --PFYDLVSTRKKKIASKQ 394
P + R+K++ KQ
Sbjct: 312 SPPPHKEARQRRKELRKKQ 330
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 52.0 bits (123), Expect = 9e-07
Identities = 35/119 (29%), Positives = 55/119 (46%), Gaps = 20/119 (16%)
Query: 262 REGWLLKLGGR-VKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPF 320
+ GWL K VK W +RWF+L D CL+Y++ ++ G IPL + V V
Sbjct: 62 KAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAV------- 114
Query: 321 CLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESI-RASITRVP 378
PS + K + G +Y SA S EE++ WI+++ A+ ++P
Sbjct: 115 -----QPSDNISRKHTFKAEHAG------VRTYFFSAESPEEQEAWIQAMGEAARVQIP 162
>gi|156616273 pleckstrin [Homo sapiens]
Length = 350
Score = 51.6 bits (122), Expect = 1e-06
Identities = 30/113 (26%), Positives = 54/113 (47%), Gaps = 19/113 (16%)
Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFC 321
REG+L+K G TWK W +L ++ + +++ +D P+G+IPL+ + P + F
Sbjct: 7 REGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKG---STLTSPCQDF- 62
Query: 322 LELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASI 374
G+++ K + K + + A EERD W+ I+ +I
Sbjct: 63 ---------GKRMFVFK------ITTTKQQDHFFQAAFLEERDAWVRDIKKAI 100
Score = 40.8 bits (94), Expect = 0.002
Identities = 30/112 (26%), Positives = 52/112 (46%), Gaps = 17/112 (15%)
Query: 262 REGWLLKLGGRVKTWKRRWFILTDN--CLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKP 319
++G LLK G R K WK R FIL ++ L+Y++ ++P G I L V V+
Sbjct: 247 KQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSVES---- 302
Query: 320 FCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIR 371
+ G+K + + ++ Y + A + +ER +WI +I+
Sbjct: 303 --------NSNGRK---SEEENLFEIITADEVHYFLQAATPKERTEWIRAIQ 343
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 50.8 bits (120), Expect = 2e-06
Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 21/116 (18%)
Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFC 321
+EG+L K GG VKTWK RWF L N L YF+ EP I+ L S + D +
Sbjct: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFD-----YS 221
Query: 322 LELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRV 377
E N C + ++ + A + E D+WI+ +R ++++
Sbjct: 222 QERVNCFC----------------LVFPFRTFYLCAKTGVEADEWIKILRWKLSQI 261
>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
sapiens]
Length = 713
Score = 50.4 bits (119), Expect = 3e-06
Identities = 24/69 (34%), Positives = 38/69 (55%), Gaps = 4/69 (5%)
Query: 260 PDREGWLLKL----GGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDD 315
PD +GWLL G W+RRWF+L + LY++ D++ G+I + N S++ D
Sbjct: 397 PDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHD 456
Query: 316 PKKPFCLEL 324
KK + +L
Sbjct: 457 QKKKYVFQL 465
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 50.1 bits (118), Expect = 4e-06
Identities = 20/49 (40%), Positives = 35/49 (71%), Gaps = 2/49 (4%)
Query: 261 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTD--KEPRGIIPLEN 307
++ G+LLK+G +VKTWKRRWF+L + Y++ +D ++P+G + L +
Sbjct: 580 EKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNS 628
Score = 33.9 bits (76), Expect = 0.26
Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 4/56 (7%)
Query: 260 PDREGWLLKLG-GRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVD 314
P +GWL K+ G K W L YY+ DK P G +P+ + +++VD
Sbjct: 688 PTVKGWLTKVKHGHSKVV---WCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVD 740
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,534,128
Number of Sequences: 37866
Number of extensions: 706962
Number of successful extensions: 2253
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 116
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 2033
Number of HSP's gapped (non-prelim): 218
length of query: 394
length of database: 18,247,518
effective HSP length: 104
effective length of query: 290
effective length of database: 14,309,454
effective search space: 4149741660
effective search space used: 4149741660
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.